| Rank City/town Department Population 2002 Census Population 1992 Census Change | |
| 1 Asunción Capital District 512,112 500,938 +2.23% | |
| 2 Ciudad del Este Alto Paraná 222,274 133,881 +66.02% | |
| 3 San Lorenzo Central 204,356 133,395 +53.20% | |
| 4 Luque Central 170,986 84,877 +101.45% | |
| 5 Capiatá Central 154,274 83,773 +84.16% | |
| 6 Lambaré Central 119,795 99,572 +20.31% | |
| 7 Fernando de la Mora Central 113,560 95,072 +19.45% | |
| 8 Limpio Central 73,158 26,177 +179.47% | |
| 9 Ñemby Central 71,909 26,999 +166.34% | |
| 10 Encarnación Itapúa 67,173 56,261 +19.40% | |
| 11 Mariano Roque Alonso Central 65,229 39,289 +66.02% | |
| 12 Pedro Juan Caballero Amambay 64,592 53,566 +20.58% | |
| 13 Villa Elisa Central 53,166 29,796 +78.43% | |
| 14 Caaguazú Caaguazú 48,941 38,220 +28.05% | |
| 15 Coronel Oviedo Caaguazú 48,773 38,316 +27.29% | |
| 16 Hernandarias Alto Paraná 47,266 28,180 +67.73% | |
| 17 Presidente Franco Alto Paraná 47,246 31,825 +48.46% | |
| 18 Itauguá Central 45,577 13,910 +227.66% | |
| 19 Concepción Concepción 43,661 35,276 +23.77% | |
| 20 Villarrica Guairá 38,961 27,818 +40.06% | |
| 21 San Antonio Central 37,795 7,371 +412.75% | |
| 22 Pilar Ñeembucú 24,300 19,121 +27.09% | |
| 23 Caacupé Cordillera 19,131 12,382 +54.51% | |
| 24 Itá Central 17,469 14,259 +22.51% | |
| 25 Mariscal Estigarribia Boquerón 16,418 16,418 0.00% | |
| 26 Villa Hayes Presidente Hayes 15,823 11,859 +33.43% | |
| 27 Minga Guazú Alto Paraná 14,806 8,914 +66.10% | |
| 28 San Ignacio Misiones 13,716 11,580 +18.45% | |
| 29 San Estanislao San Pedro 13,202 9,132 +44.57% | |
| 30 Ayolas Misiones 10,851 9,143 +18.68% | |
| 31 Villeta Central 10,106 7,439 +35.85% | |
| 32 Areguá Central 10,009 6,374 +57.03% | |