| Year,Title,Role,Notes | |
| 1967,Up the Down Staircase,Charlotte Wolf,- | |
| 1967,The Tiger Makes Out,Lady on Bus,- | |
| 1971,The Hospital,Mrs. Cushing,- | |
| 1973,Two People,Mrs. McCluskey,- | |
| 1978,Fedora,Miss Balfour,- | |
| 1979,Starting Over,Marva Potter,- | |
| 1981,Outland,Dr. Marian Lazarus,Saturn Award for Best Supporting Actress | |
| 1983,Independence Day,Carla Taylor,- | |
| 1983,Romantic Comedy,Blanche Dailey,- | |
| 1986,Resting Place,Eudora McCallister,- | |
| 1988,"Bright Lights, Big City",Clara,- | |
| 1989,Communion,Dr. Janet Duffy,- | |
| 1989,See You in the Morning,Neenie,- | |
| 1990,Sibling Rivalry,Rose Turner,- | |
| 1990,Misery,Virginia,Nominated—Saturn Award for Best Supporting Actress | |
| 1991,Doc Hollywood,Lillian,- | |
| 1991,Walking the Dog,Antique Dealer,Short film | |
| 1992,Raising Cain,Dr. Lynn Waldheim,Nominated—Saturn Award for Best Supporting Actress | |
| 1998,It All Came True,Amy,- | |
| 2000,Midnight Gospel,Ruth,Short film | |
| 2001,Landfall,Emily Thornton,- | |
| 2001,The Rising Place,Ruth Wilder,- | |
| 2002,Highway,Mrs. Murray,- | |
| 2007,The Mist,Irene Reppler,- | |
| 2009,Julie & Julia,Irma Rombauer,- | |
| 2011,Dolphin Tale,Gloria Forrest,- | |
| 2014,And So It Goes,Claire,- | |