| Rank,Lane,Name,Nationality,Time,Notes | |
| -,3,Ryan Lochte,United States,4:05.18,- | |
| -,6,Thiago Pereira,Brazil,4:08.86,SA | |
| -,4,Kosuke Hagino,Japan,4:08.94,AS | |
| 4,8,Michael Phelps,United States,4:09.28,- | |
| 5,5,Chad le Clos,South Africa,4:12.42,- | |
| 6,1,Yuya Horihata,Japan,4:13.30,- | |
| 7,2,Thomas Fraser-Holmes,Australia,4:13.49,- | |
| 8,7,Luca Marin,Italy,4:14.89,- | |