| Year Title Role Notes | |
| 1967 Up the Down Staircase Charlotte Wolf - | |
| 1967 The Tiger Makes Out Lady on Bus - | |
| 1971 The Hospital Mrs. Cushing - | |
| 1973 Two People Mrs. McCluskey - | |
| 1978 Fedora Miss Balfour - | |
| 1979 Starting Over Marva Potter - | |
| 1981 Outland Dr. Marian Lazarus Saturn Award for Best Supporting Actress | |
| 1983 Independence Day Carla Taylor - | |
| 1983 Romantic Comedy Blanche Dailey - | |
| 1986 Resting Place Eudora McCallister - | |
| 1988 Bright Lights, Big City Clara - | |
| 1989 Communion Dr. Janet Duffy - | |
| 1989 See You in the Morning Neenie - | |
| 1990 Sibling Rivalry Rose Turner - | |
| 1990 Misery Virginia Nominated—Saturn Award for Best Supporting Actress | |
| 1991 Doc Hollywood Lillian - | |
| 1991 Walking the Dog Antique Dealer Short film | |
| 1992 Raising Cain Dr. Lynn Waldheim Nominated—Saturn Award for Best Supporting Actress | |
| 1998 It All Came True Amy - | |
| 2000 Midnight Gospel Ruth Short film | |
| 2001 Landfall Emily Thornton - | |
| 2001 The Rising Place Ruth Wilder - | |
| 2002 Highway Mrs. Murray - | |
| 2007 The Mist Irene Reppler - | |
| 2009 Julie & Julia Irma Rombauer - | |
| 2011 Dolphin Tale Gloria Forrest - | |
| 2014 And So It Goes Claire - | |