| Rank | Player | Premier League club(s) | National team | Goals | Played | Ratio |
| 1 | Alan Shearer | Blackburn Rovers, Newcastle United | England | 260 | 441 | 0.59 |
| 2 | Wayne Rooney | Everton, Manchester United | England | 208 | 494 | 0.42 |
| 3 | Andy Cole | Newcastle United, Manchester United, Blackburn Rovers, Fulham, Manchester City, Portsmouth | England | 187 | 414 | 0.45 |
| 4 | Frank Lampard | West Ham United, Chelsea, Manchester City | England | 177 | 609 | 0.29 |
| 5 | Thierry Henry | Arsenal | France | 175 | 258 | 0.68 |
| 6 | Sergio Agüero | Manchester City | Argentina | 163 | 237 | 0.69 |
| 6 | Robbie Fowler | Liverpool, Leeds United, Manchester City, Blackburn Rovers | England | 163 | 379 | 0.43 |
| 7 | Jermain Defoe | West Ham United, Portsmouth, Tottenham Hotspur, Sunderland, Bournemouth | England | 162 | 496 | 0.33 |
| 9 | Michael Owen | Liverpool, Newcastle United, Manchester United, Stoke City | England | 150 | 326 | 0.46 |
| 10 | Les Ferdinand | Queens Park Rangers, Newcastle United, Tottenham Hotspur, West Ham United, Leicester City, Bolton Wanderers | England | 149 | 351 | 0.42 |
| 11 | Teddy Sheringham | Nottingham Forest, Tottenham Hotspur, Manchester United, Portsmouth, West Ham United | England | 146 | 418 | 0.35 |
| 12 | Robin van Persie | Arsenal, Manchester United | Netherlands | 144 | 280 | 0.51 |
| 13 | Jimmy Floyd Hasselbaink | Leeds United, Chelsea, Middlesbrough, Charlton Athletic | Netherlands | 127 | 288 | 0.44 |
| 14 | Robbie Keane | Coventry City, Leeds United, Tottenham Hotspur, Liverpool, West Ham United, Aston Villa | Republic of Ireland | 126 | 349 | 0.36 |
| 15 | Harry Kane | Tottenham Hotspur, Norwich City | England | 125 | 181 | 0.69 |
| 15 | Nicolas Anelka | Arsenal, Liverpool, Manchester City, Bolton Wanderers, Chelsea, West Bromwich Albion | France | 125 | 364 | 0.34 |
| 17 | Dwight Yorke | Aston Villa, Manchester United, Blackburn Rovers, Birmingham City, Sunderland | Trinidad and Tobago | 123 | 375 | 0.33 |
| 18 | Steven Gerrard | Liverpool | England | 120 | 504 | 0.24 |
| 19 | Ian Wright | Arsenal, West Ham United | England | 113 | 213 | 0.53 |
| 19 | Romelu Lukaku | Chelsea, West Bromwich Albion, Everton, Manchester United | Belgium | 113 | 252 | 0.45 |
| 21 | Dion Dublin | Manchester United, Coventry City, Aston Villa | England | 111 | 312 | 0.36 |
| 22 | Emile Heskey | Leicester City, Liverpool, Birmingham City, Wigan Athletic, Aston Villa | England | 110 | 516 | 0.21 |
| 23 | Ryan Giggs | Manchester United | Wales | 109 | 632 | 0.17 |
| 24 | Peter Crouch | Aston Villa, Southampton, Liverpool, Portsmouth, Tottenham Hotspur, Stoke City, Burnley | England | 108 | 467 | 0.23 |
| 25 | Paul Scholes | Manchester United | England | 107 | 499 | 0.21 |
| 26 | Darren Bent | Ipswich Town, Charlton Athletic, Tottenham Hotspur, Sunderland, Aston Villa, Fulham | England | 106 | 276 | 0.38 |
| 27 | Didier Drogba | Chelsea | Ivory Coast | 104 | 254 | 0.41 |
| 28 | Matt Le Tissier | Southampton | England | 100 | 270 | 0.37 |
| As of 29 April 2019. Sources: | As of 29 April 2019. Sources: | As of 29 April 2019. Sources: | As of 29 April 2019. Sources: | As of 29 April 2019. Sources: | As of 29 April 2019. Sources: | As of 29 April 2019. Sources: |