| | Year FBS Opponent Result Opponent's Conference Opponent's Head Coach Charleston Southern's Head Coach |
| | 2015 Alabama Crimson Tide TBD SEC Nick Saban Jamey Chadwell |
| | 2014 Georgia Bulldogs TBD SEC Mark Richt Jamey Chadwell |
| | 2014 Vanderbilt Commodores TBD SEC Derek Mason Jamey Chadwell |
| | 2013 Colorado Buffaloes L, 43-10 Pac-12 Mike MacIntyre Jamey Chadwell |
| | 2012 Illinois Fighting Illini L, 44-0 Big Ten Tim Beckman Jay Mills |
| | 2011 UCF Knights L, 62-0 C-USA George O'Leary Jay Mills |
| | 2011 Florida State Seminoles L, 62-10 ACC Jimbo Fisher Jay Mills |
| | 2010 Kentucky Wildcats L, 49-21 SEC Joker Phillips Jay Mills |
| | 2010 Hawaii Warriors L, 66-7 WAC Greg McMackin Jay Mills |
| | 2009 South Florida Bulls L, 59-0 Big East Jim Leavitt Jay Mills |
| | 2009 Florida Gators L, 62-3 SEC Urban Meyer Jay Mills |
| | 2008 Miami Redhawks L, 38-27 MAC Don Treadwell Jay Mills |
| | 2008 Miami Hurricanes L, 52-7 ACC Randy Shannon Jay Mills |
| | 2007 Hawaii Warriors L, 66-10 WAC June Jones Jay Mills |
| | 2003 South Florida Bulls L, 55-7 Big East Jim Leavitt Jay Mills |
| | 2002 South Florida Bulls L, 56-6 Big East Jim Leavitt David Dowd |
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