| | | Rank | Title | Studio | Actor/Actress | Director | Gross | |
| | | 1. | Three Men and a Baby | Touchstone | Tom Selleck, Ted Danson, and Steve Guttenberg | Leonard Nimoy | $167,780,960 | |
| | | 2. | Fatal Attraction | Paramount | Michael Douglas, Glenn Close, and Anne Archer | Adrian Lyne | $156,645,693 | |
| | | 3. | Beverly Hills Cop II | Paramount | Eddie Murphy, Judge Reinhold, Brigitte Nielsen, John Ashton, and Paul Reiser | Tony Scott | $153,665,036 | |
| | | 4. | Good Morning, Vietnam | Touchstone | Robin Williams and Forest Whitaker | Barry Levinson | $123,922,370 | |
| | | 5. | Moonstruck | MGM | Cher, Nicolas Cage, Olympia Dukakis, Vincent Gardenia, and Danny Aiello | Norman Jewison | $80,640,528 | |
| | | 6. | The Untouchables | Paramount | Kevin Costner, Sean Connery, Robert De Niro, Andy García, and Charles Martin Smith | Brian De Palma | $76,270,454 | |
| | | 7. | The Secret of My Success | Universal | Michael J. Fox, Helen Slater, Margaret Whitton, and Richard Jordan | Herbert Ross | $66,995,000 | |
| | | 8. | Stakeout | Touchstone | Richard Dreyfuss, Emilio Estevez, Madeleine Stowe, and Aidan Quinn | John Badham | $65,673,233 | |
| | | 9. | Lethal Weapon | Warner Bros. | Mel Gibson, Danny Glover, and Gary Busey | Richard Donner | $65,207,127 | |
| | | 10. | Dirty Dancing | Vestron | Patrick Swayze, Jennifer Grey, Jerry Orbach, and Cynthia Rhodes | Emile Ardolino | $63,892,689 | |
| | | 11. | The Witches of Eastwick | Warner Bros. | Jack Nicholson, Cher, Susan Sarandon, Michelle Pfeiffer | George Miller | $63,766,510 | |
| | | 12. | Predator | Fox | Arnold Schwarzenegger, Carl Weathers, Jesse Ventura, Bill Duke, Shane Black, and Kevin Peter Hall | John McTiernan | $59,735,548 | |
| | | 13. | Throw Momma from the Train | Orion | Danny DeVito, Billy Crystal, Kate Mulgrew, and Anne Ramsey | Danny DeVito | $57,915,972 | |
| | | 14. | Dragnet | Universal | Dan Aykroyd, Tom Hanks, Alexandra Paul, Christopher Plummer, and Dabney Coleman | Tom Mankiewicz | $57,387,516 | |
| | | 15. | RoboCop | Orion | Peter Weller, Nancy Allen, Ronny Cox, Kurtwood Smith, Miguel Ferrer, and Dan O'Herlihy | Paul Verhoeven | $53,424,681 | |
| | | 16. | Outrageous Fortune | Touchstone | Bette Midler and Shelley Long | Arthur Hiller | $52,864,741 | |
| | | 17. | La Bamba | Columbia | Lou Diamond Phillips, Esai Morales, Rosana DeSoto, Elizabeth Peña, and Danielle von Zerneck | Luis Valdez | $52,678,820 | |
| | | 18. | Broadcast News | Fox | William Hurt, Holly Hunter, and Albert Brooks | James L. Brooks | $51,300,000 | |
| | | 19. | The Living Daylights | United Artists | Timothy Dalton and Maryam d'Abo | John Glen | $51,185,000 | |
| | | 20. | Eddie Murphy Raw | Paramount | Eddie Murphy | Robert Townsend | $50,505,655 | |
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