| | Rank Area State/\nProvince CSA/CMA\n2009 population Projected\n2025 population Projected increase\n2009–2025 |
| | 1 Chicago IL-IN-WI 9,804,845 10,935,100 1,130,255 |
| | 2 Toronto ON 5,741,400 7,408,000 1,666,600 |
| | 3 Detroit MI 5,327,764 6,191,000 863,236 |
| | 4 Cleveland OH 2,891,988 3,172,000 280,012 |
| | 5 Milwaukee WI 1,760,268 1,913,000 157,732 |
| | 6 Ottawa – Gatineau ON-QC 1,451,415 1,596,556 145,141 |
| | 7 Grand Rapids MI 1,327,366 1,530,000 202,634 |
| | 8 Buffalo NY 1,203,493 1,040,400 -163,093 |
| | 9 Rochester NY 1,149,653 1,248,600 98,947 |
| | 10 Hamilton ON 740,200 954,858 214,658 |
| | 11 Toledo OH 672,220 672,220 0 |
| | 12 Lansing MI 523,609 547,325 23,716 |
| | 13 Kitchener – Cambridge – Waterloo ON 492,400 635,196 142,796 |
| | 14 London ON 492,200 634,938 142,738 |
| | 15 Fort Wayne IN 414,315 455,623 39,366 |
| | 16 St. Catharines – Niagara ON 404,400 521,676 117,276 |
| | 17 Windsor ON 330,900 426,861 95,961 |
| | 18 Erie PA 280,985 N/A N/A |
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