| | "Team","Outgoing manager","Manner of departure","Date of vacancy","Replaced by","Date of appointment","Position in table" |
| | "Crystal Palace","Peter Taylor","Contract terminated","8 October 2007","Neil Warnock","11 October 2007","19th" |
| | "Leicester City","Martin Allen","Mutual consent","29 August 2007","Gary Megson","13 September 2007","9th" |
| | "Queens Park Rangers","John Gregory","Contract terminated","1 October 2007","Luigi De Canio","29 October 2007","24th" |
| | "Norwich City","Peter Grant","Mutual consent","8 October 2007","Glenn Roeder","30 October 2007","22nd" |
| | "Leicester City","Gary Megson","Mutual consent (hired by Bolton Wanderers)","24 October 2007","Ian Holloway","22 November 2007","19th" |
| | "Burnley","Steve Cotterill","Mutual consent","8 November 2007","Owen Coyle","22 November 2007","15th" |
| | "Preston North End","Paul Simpson","Contract terminated","13 November 2007","Alan Irvine","20 November 2007","21st" |
| | "Plymouth Argyle","Ian Holloway","Resigned (hired by Leicester City)","21 November 2007","Paul Sturrock","27 November 2007","7th" |
| | "Coventry City","Iain Dowie","Contract terminated","11 February 2008","Chris Coleman","19 February 2008","19th" |
| | "Sheffield United","Bryan Robson","Mutual consent","14 February 2008","Kevin Blackwell","14 February 2008","16th" |
| | "Queens Park Rangers","Luigi De Canio","Mutual consent","8 May 2008","Iain Dowie","14 May 2008","14th" |
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