| | Week Date TV Time Opponent Result Game site Record Attendance |
| | 1 September 7, 1998 ABC 7:00 pm MT New England Patriots W 27–21 Mile High Stadium (ABC) 1–0 74,745 |
| | 2 September 13, 1998 FOX 2:00 pm MT Dallas Cowboys W 42–23 Mile High Stadium (FOX) 2–0 75,013 |
| | 3 September 20, 1998 CBS 2:00 pm MT at Oakland Raiders W 34–17 Oakland-Alameda County Coliseum (CBS) 3–0 56,578 |
| | 4 September 27, 1998 CBS 11:00 am MT at Washington Redskins W 38–16 FedEx Field (CBS) 4–0 71,880 |
| | 5 October 4, 1998 FOX 2:00 pm MT Philadelphia Eagles W 41–16 Mile High Stadium (FOX) 5–0 73,218 |
| | 6 October 11, 1998 CBS 2:00 pm MT at Seattle Seahawks W 21–16 Kingdome (CBS) 6–0 66,258 |
| | 7 Bye Bye Bye Bye Bye Bye Bye |
| | 8 October 25, 1998 CBS 2:00 pm MT Jacksonville Jaguars W 37–24 Mile High Stadium (CBS) 7–0 75,217 |
| | 9 November 1, 1998 CBS 11:00 am MT at Cincinnati Bengals W 33–26 Cinergy Field (CBS) 8–0 59,974 |
| | 10 November 8, 1998 CBS 2:00 pm MT San Diego Chargers W 27–10 Mile High Stadium (CBS) 9–0 74,925 |
| | 11 November 16, 1998 ABC 7:00 pm MT at Kansas City Chiefs W 30–7 Arrowhead Stadium (ABC) 10–0 78,100 |
| | 12 November 22, 1998 CBS 2:00 pm MT Oakland Raiders W 40–14 Mile High Stadium (CBS) 11–0 75,325 |
| | 13 November 29, 1998 ESPN 6:15 pm MT at San Diego Chargers W 31–16 Qualcomm Stadium (ESPN) 12–0 66,532 |
| | 14 December 6, 1998 CBS 2:00 pm MT Kansas City Chiefs W 35–31 Mile High Stadium (CBS) 13–0 74,962 |
| | 15 December 13, 1998 CBS 11:00 am MT at New York Giants L 16–20 Giants Stadium (CBS) 13–1 72,336 |
| | 16 December 21, 1998 ABC 7:00 pm MT at Miami Dolphins L 21–31 Pro Player Stadium (ABC) 13–2 74,363 |
| | 17 December 27, 1998 CBS 2:15 pm MT Seattle Seahawks W 28–21 Mile High Stadium (CBS) 14–2 74,057 |
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