| | Battle, Siege, or Offensive Conflict Dates Estimated number of Americans killed |
| | Meuse-Argonne Offensive World War I September 26 to November 11, 1918 26,277 killed |
| | Battle of the Bulge World War II December 16, 1944 to January 25, 1945 19,276 killed |
| | Battle of Normandy World War II June 6 to July 24, 1944 16,293 killed |
| | Battle of Okinawa World War II April 1 to June 21, 1945 12,513 killed |
| | Battle of Hürtgen Forest World War II September 19, 1944 to February 10, 1945 Over 12,000 killed |
| | Battle of Gettysburg American Civil War July 1 to July 3, 1863 7,863 killed (3,155 Union and 4,708 Confederacy) |
| | Battle of Guadalcanal World War II August 7, 1942 to February 9, 1943 7,100 killed |
| | Battle of Iwo Jima World War II February 16 to March 26, 1945 7,000 killed |
| | Battle of Anzio World War II January 22 to June 5, 1944 5,538 killed |
| | Battle of Pusan Perimeter Korean War August to September, 1950 4,599 killed |
| | Battle of Spotsylvania American Civil War May 8 to May 21, 1864 4,192 killed (2,725 Union and 1,467 Confederacy) |
| | Battle of Chickamauga American Civil War September 19 to September 20, 1863 3,969 killed (1,657 Union and 2,312 Confederacy) |
| | Battle of the Wilderness American Civil War May 5 to May 7, 1864 3,741 killed (2,246 Union and 1,495 Confederacy) |
| | Battle of Antietam American Civil War September 17, 1862 3,654 killed (2,108 Union and 1,546 Confederacy) |
| | Battle of Shiloh American Civil War April 6 to April 7, 1862 3,482 killed (1,754 Union and 1,728 Confederacy) |
| | Battle of Chancellorsville American Civil War April 30 to May 6, 1863 3,271 killed (1,606 Union and 1,665 Confederacy) |
| | Battle of Saipan World War II June 15 to July 9 1944 2,949 killed |
| | Battle of Sicily World War II July 9 to August 17, 1943 2,572 killed |
| | Pearl Harbor Attack World War II December 7, 1941 2,500 killed |
| | Battle of Salerno World War II September 3 – September 16, 1943 2,000 killed |
| | Battle of Belleau Wood World War I June 1 to June 26, 1918 1,811 killed |
| | Battle of Peleliu World War II September 15 to November 27, 1944 1,794 killed |
| | Second Battle of Guam World War II July 21 to August 8, 1944 1,747 killed, |
| | Battle of Tarawa World War II November 20 to November 23, 1943 1,677 killed |
| | D-day (first day of Operation Overlord) World War II June 6, 1944 1,465 killed |
| | Battle of Chosin Reservoir Korean War November 27 to December 13, 1950 1,029 killed |
| | Battle for Manila World War II February 3 to March 3, 1945 1,010 killed |
| | Battle of the Kasserine Pass World War II February 19 to February 25, 1943 Over 1,000 killed |
| | Battle of Taejon Korean War July 14 to July 21, 1950 922 killed |
| | Battle of Khe Sanh Vietnam War 21 January to 8 April 1968 737 killed |
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