| Sentence_ID,Text_Content,Entities_JSON,Relations_JSON,Source_Article_Title,PMID | |
| S001,"Treatment with 'Paclitaxel' and 'Carboplatin' led to a reduction in 'Tumor_Volume' in 'Non_Small_Cell_Lung_Cancer'.",["Paclitaxel","Carboplatin","Tumor_Volume","Non_Small_Cell_Lung_Cancer"],["TREATS(Paclitaxel,Non_Small_Cell_Lung_Cancer)","TREATS(Carboplatin,Non_Small_Cell_Lung_Cancer)","REDUCES(Paclitaxel,Tumor_Volume)"],A Phase II Study of Carboplatin and Paclitaxel,30123456 | |
| S002,"The 'APOE4' allele is a known 'Risk_Factor' for 'Alzheimer's_Disease', influencing 'Amyloid_Beta' deposition.",["APOE4","Risk_Factor","Alzheimer's_Disease","Amyloid_Beta"],["CAUSES(APOE4,Alzheimer's_Disease)","ASSOCIATED_WITH(APOE4,Amyloid_Beta)"],Genetic Risk Factors in Neurodegenerative Disorders,30123457 | |
| S003,"'Metformin' is often prescribed to manage 'Type_2_Diabetes', primarily by reducing 'Hepatic_Glucose_Output'.",["Metformin","Type_2_Diabetes","Hepatic_Glucose_Output"],["TREATS(Metformin,Type_2_Diabetes)","REGULATES(Metformin,Hepatic_Glucose_Output)"],Metformin's Mechanism of Action,30123458 | |
| S004,"High expression of 'EGFR' suggests resistance to 'Cetuximab' in 'Colorectal_Cancer' patients.",["EGFR","Cetuximab","Colorectal_Cancer"],["INDICATOR_OF_RESISTANCE(EGFR,Cetuximab)","TARGETS(Cetuximab,EGFR)"],EGFR Status and Anti-EGFR Therapy,30123459 | |
| S005,"Exposure to 'Formaldehyde' is linked to increased risk of 'Leukemia', especially the 'Myeloid_Leukemia' subtype.",["Formaldehyde","Leukemia","Myeloid_Leukemia"],["CAUSES(Formaldehyde,Leukemia)","IS_A(Myeloid_Leukemia,Leukemia)"],Occupational Exposure and Hematologic Malignancies,30123460 | |
| S006,"Inhibition of 'VEGF' with 'Bevacizumab' is a strategy to limit 'Angiogenesis' in various 'Solid_Tumors'.",["VEGF","Bevacizumab","Angiogenesis","Solid_Tumors"],["INHIBITS(Bevacizumab,VEGF)","REGULATES(Bevacizumab,Angiogenesis)"],Anti-Angiogenic Strategies in Oncology,30123461 | |
| S007,"A deficiency in 'Vitamin_D' is correlated with lower 'Bone_Density' and increased risk of 'Osteoporosis'.",["Vitamin_D","Bone_Density","Osteoporosis"],["ASSOCIATED_WITH(Vitamin_D,Bone_Density)","CAUSES(Vitamin_D,Osteoporosis)"],The Role of Vitamin D in Skeletal Health,30123462 | |
| S008,"Mutations in the 'BRCA1' gene significantly increase susceptibility to 'Breast_Cancer' and 'Ovarian_Cancer'.",["BRCA1","Breast_Cancer","Ovarian_Cancer"],["CAUSES(BRCA1,Breast_Cancer)","CAUSES(BRCA1,Ovarian_Cancer)"],Hereditary Cancer Syndromes,30123463 | |
| S009,"'Fentanyl' is a potent 'Opioid_Analgesic' primarily acting on 'Mu_Receptors' in the 'Central_Nervous_System'.",["Fentanyl","Opioid_Analgesic","Mu_Receptors","Central_Nervous_System"],["IS_A(Fentanyl,Opioid_Analgesic)","TARGETS(Fentanyl,Mu_Receptors)"],Pharmacology of Synthetic Opioids,30123464 | |
| S010,"The 'H1N1' virus, a type of 'Influenza_Virus', caused a global 'Pandemic' in 2009.",["H1N1","Influenza_Virus","Pandemic"],["IS_A(H1N1,Influenza_Virus)","CAUSES(H1N1,Pandemic)"],Epidemiology of 2009 H1N1,30123465 | |
| S011,"'Losartan' is an 'Angiotensin_II_Receptor_Blocker' used for managing 'Hypertension'.",["Losartan","Angiotensin_II_Receptor_Blocker","Hypertension"],["IS_A(Losartan,Angiotensin_II_Receptor_Blocker)","TREATS(Losartan,Hypertension)"],ARBs in Cardiovascular Medicine,30123466 | |
| S012,"'Aspirin' inhibits 'Platelet_Aggregation' and is crucial for preventing 'Myocardial_Infarction'.",["Aspirin","Platelet_Aggregation","Myocardial_Infarction"],["INHIBITS(Aspirin,Platelet_Aggregation)","PREVENTS(Aspirin,Myocardial_Infarction)"],Antiplatelet Therapy Guidelines,30123467 | |
| S013,"The neurotoxin 'Botulinum_Toxin' causes 'Muscle_Paralysis' by blocking 'Acetylcholine' release.",["Botulinum_Toxin","Muscle_Paralysis","Acetylcholine"],["CAUSES(Botulinum_Toxin,Muscle_Paralysis)","REGULATES(Botulinum_Toxin,Acetylcholine)"],Mechanisms of Neurotoxin Action,30123468 | |
| S014,"Elevated levels of 'C-Reactive_Protein' are a biomarker for systemic 'Inflammation'.",["C-Reactive_Protein","Inflammation"],["INDICATOR_OF(C-Reactive_Protein,Inflammation)"],CRP as an Inflammatory Marker,30123469 | |
| S015,"'Glioblastoma' is the most aggressive form of 'Brain_Cancer', often treated with 'Temozolomide'.",["Glioblastoma","Brain_Cancer","Temozolomide"],["IS_A(Glioblastoma,Brain_Cancer)","TREATS(Temozolomide,Glioblastoma)"],Standard Treatment for Glioblastoma,30123470 | |
| S016,"Research suggests 'Resveratrol' may modulate 'Sirtuin_Activity', impacting 'Cellular_Aging'.",["Resveratrol","Sirtuin_Activity","Cellular_Aging"],["MODULATES(Resveratrol,Sirtuin_Activity)","ASSOCIATED_WITH(Resveratrol,Cellular_Aging)"],Nutraceuticals and Longevity,30123471 | |
| S017,"Vaccination against 'Measles' provides robust protection against the highly contagious 'Morbillivirus'.",["Measles","Morbillivirus"],["PREVENTS(Vaccination,Measles)","CAUSED_BY(Measles,Morbillivirus)"],Global Eradication of Measles,30123472 | |
| S018,"'Dupilumab' is a monoclonal antibody targeting 'IL-4' and 'IL-13' for the treatment of 'Atopic_Dermatitis'.",["Dupilumab","IL-4","IL-13","Atopic_Dermatitis"],["TARGETS(Dupilumab,IL-4)","TREATS(Dupilumab,Atopic_Dermatitis)"],Biologics in Dermatology,30123473 | |
| S019,"Chronic exposure to 'UV_Radiation' is the primary cause of 'Basal_Cell_Carcinoma', a type of 'Skin_Cancer'.",["UV_Radiation","Basal_Cell_Carcinoma","Skin_Cancer"],["CAUSES(UV_Radiation,Basal_Cell_Carcinoma)","IS_A(Basal_Cell_Carcinoma,Skin_Cancer)"],Photocarcinogenesis Mechanisms,30123474 | |
| S020,"Genetic variations in 'CYP2D6' affect the metabolism of 'Codeine', influencing its therapeutic effect.",["CYP2D6","Codeine"],["REGULATES(CYP2D6,Codeine)"],Pharmacogenomics of Opioids,30123475 | |
| S021,"The 'Zika_Virus' infection in pregnant women can cause 'Microcephaly' in the developing 'Fetus'.",["Zika_Virus","Microcephaly","Fetus"],["CAUSES(Zika_Virus,Microcephaly)","TARGETS(Zika_Virus,Fetus)"],Congenital Zika Syndrome,30123476 | |
| S022,"'Ibuprofen' is a common 'NSAID' used for 'Pain_Relief' and reducing 'Fever'.",["Ibuprofen","NSAID","Pain_Relief","Fever"],["IS_A(Ibuprofen,NSAID)","TREATS(Ibuprofen,Pain_Relief)","TREATS(Ibuprofen,Fever)"],Mechanism of Action of NSAIDs,30123477 | |
| S023,"Depletion of 'Dopamine' in the 'Substantia_Nigra' is characteristic of 'Parkinson's_Disease'.",["Dopamine","Substantia_Nigra","Parkinson's_Disease"],["ASSOCIATED_WITH(Dopamine,Parkinson's_Disease)","LOCATION(Dopamine,Substantia_Nigra)"],Neurochemistry of Movement Disorders,30123478 | |
| S024,"Targeting 'PD-1' with 'Pembrolizumab' has shown efficacy in treating 'Melanoma'.",["PD-1","Pembrolizumab","Melanoma"],["TARGETS(Pembrolizumab,PD-1)","TREATS(Pembrolizumab,Melanoma)"],Immune Checkpoint Blockade Therapy,30123479 | |
| S025,"'Type_1_Diabetes' is an 'Autoimmune_Disease' resulting in the destruction of 'Beta_Cells' in the 'Pancreas'.",["Type_1_Diabetes","Autoimmune_Disease","Beta_Cells","Pancreas"],["IS_A(Type_1_Diabetes,Autoimmune_Disease)","LOCATION(Beta_Cells,Pancreas)"],Immunology of Type 1 Diabetes,30123480 | |
| S026,"The drug 'Warfarin' functions as an 'Anticoagulant' by inhibiting 'Vitamin_K' dependent factors.",["Warfarin","Anticoagulant","Vitamin_K"],["IS_A(Warfarin,Anticoagulant)","INHIBITS(Warfarin,Vitamin_K)"],Oral Anticoagulation Therapy,30123481 | |
| S027,"Infection with 'Helicobacter_pylori' is strongly linked to the development of 'Gastric_Ulcers'.",["Helicobacter_pylori","Gastric_Ulcers"],["CAUSES(Helicobacter_pylori,Gastric_Ulcers)"],H. pylori and Peptic Ulcer Disease,30123482 | |
| S028,"The small molecule 'Thalidomide' possesses both 'Immunomodulatory' and 'Anti-angiogenic' properties.",["Thalidomide","Immunomodulatory","Anti-angiogenic"],["HAS_PROPERTY(Thalidomide,Immunomodulatory)","HAS_PROPERTY(Thalidomide,Anti-angiogenic)"],Repurposing Thalidomide,30123483 | |
| S029,"'Chronic_Kidney_Disease' often leads to 'Anemia' due to reduced production of 'Erythropoietin'.",["Chronic_Kidney_Disease","Anemia","Erythropoietin"],["CAUSES(Chronic_Kidney_Disease,Anemia)","REGULATES(Erythropoietin,Anemia)"],Renal Anemia Pathophysiology,30123484 | |
| S030,"Inhaled 'Corticosteroids' are the cornerstone for long-term control of persistent 'Asthma'.",["Corticosteroids","Asthma"],["TREATS(Corticosteroids,Asthma)"],Guidelines for Asthma Management,30123485 | |
| S031,"A lack of 'Iodine' in the diet can lead to 'Thyroid_Dysfunction' and 'Goiter'.",["Iodine","Thyroid_Dysfunction","Goiter"],["CAUSES(Iodine,Thyroid_Dysfunction)","CAUSES(Iodine,Goiter)"],Micronutrient Deficiencies,30123486 | |
| S032,"The drug 'Sofosbuvir' revolutionized the treatment of 'Hepatitis_C_Virus' infection.",["Sofosbuvir","Hepatitis_C_Virus"],["TREATS(Sofosbuvir,Hepatitis_C_Virus)"],Direct-Acting Antivirals for HCV,30123487 | |
| S033,"Excessive consumption of 'Sodium' is a major contributor to 'Hypertension'.",["Sodium","Hypertension"],["CAUSES(Sodium,Hypertension)"],Dietary Sodium and Blood Pressure,30123488 |