| Paper_ID,Year,Title,Abstract_Text,Methodology_Keywords,Target_Organism,Research_Field,Classification_Label | |
| BMD_001,2023,Novel AAV-Mediated Gene Therapy for Retinal Degeneration,We explore the efficacy of a novel adeno-associated virus (AAV) vector carrying the RPE65 gene in mouse models of Leber congenital amaurosis. Results show significant restoration of photoreceptor function and visual acuity. The treatment was well-tolerated.,Gene Therapy; AAV Vector; In Vivo; Electrophysiology,Mus musculus,Ophthalmology,Therapeutic Intervention | |
| BMD_002,2022,Single-Cell Transcriptomics of Tumor Microenvironment in Glioblastoma,Profiling over 10,000 cells from patient-derived glioblastoma samples revealed distinct immune cell subtypes and novel cellular communication pathways. This data suggests potential targets for personalized immunotherapy.,Single-Cell RNA-Seq; Tumor Microenvironment; Bioinformatics; scRNA-seq,Homo sapiens,Neuro-Oncology,Molecular Mechanism | |
| BMD_003,2024,Cryo-EM Structure of the SARS-CoV-2 Spike Protein in Complex with a Human Receptor,High-resolution cryo-electron microscopy was used to determine the structure of the SARS-CoV-2 Spike protein bound to the ACE2 receptor. Structural insights will aid in the rational design of next-generation vaccines and antivirals.,Cryo-Electron Microscopy; Protein Structure; Receptor Binding; X-ray Crystallography,In Vitro,Structural Biology,Diagnostic/Imaging | |
| BMD_004,2023,Machine Learning Prediction of Antibiotic Resistance in Klebsiella pneumoniae,We developed a random forest model using whole-genome sequencing (WGS) data to predict resistance to carbapenems in clinical isolates of K. pneumoniae. The model achieved 95% accuracy in a validation cohort.,Machine Learning; Whole-Genome Sequencing; Predictive Modeling; Bioinformatics,Klebsiella pneumoniae,Microbiology,Genomics/Proteomics | |
| BMD_005,2022,Metabolic Reprogramming in Senescent Human Fibroblasts,Flux analysis and untargeted metabolomics demonstrated a shift towards glycolysis and decreased mitochondrial respiration in induced senescent primary human dermal fibroblasts. Key enzyme activity was altered.,Metabolomics; Cell Culture; Seahorse Assay; Flow Cytometry,Homo sapiens,Aging/Gerontology,Cellular Processes | |
| BMD_006,2024,Deep Brain Stimulation Modulates Cortical-Striatal Circuits in Parkinson's Disease,Using fMRI in non-human primates, we investigated the effect of deep brain stimulation (DBS) on functional connectivity in the basal ganglia. DBS at 130 Hz significantly normalized pathological oscillations.,fMRI; Deep Brain Stimulation; Functional Connectivity; Animal Model,Macaca mulatta,Neuroscience,Therapeutic Intervention | |
| BMD_007,2023,The Role of microRNA-122 in Hepatocellular Carcinoma Progression,Overexpression of miR-122 significantly suppressed proliferation and invasion of liver cancer cell lines by targeting the expression of IGF-1R. In vivo studies confirmed tumor suppression.,microRNA; Cell Line; Western Blot; Xenograft Model,Homo sapiens,Hepatology,Molecular Mechanism | |
| BMD_008,2022,Development of a Novel Polymeric Nanoparticle for Oral Insulin Delivery,A pH-sensitive, self-assembling polymer system was engineered to encapsulate insulin. In diabetic rat models, oral administration achieved therapeutic plasma insulin levels and regulated blood glucose.,Nanoparticle; Drug Delivery; Polymer Chemistry; Pharmacokinetics,Rattus norvegicus,Pharmacology,Drug Development | |
| BMD_009,2024,Longitudinal Analysis of Cognitive Decline in Alzheimer's Disease Cohort,A five-year follow-up study of 500 patients utilized PET imaging and CSF biomarkers (Tau, Amyloid-$\beta$) to track disease progression. Novel risk factors were identified via survival analysis.,Longitudinal Study; PET Imaging; Biomarkers; Survival Analysis,Homo sapiens,Neurology,Epidemiology | |
| BMD_010,2023,High-Throughput Screening Identifies Potent Inhibitors of M. tuberculosis Respiration,A library of 50,000 small molecules was screened against the respiratory chain of Mycobacterium tuberculosis. Three lead compounds exhibited sub-micromolar inhibitory concentration and low cytotoxicity.,High-Throughput Screening; Small Molecule; MIC Assay; In Vitro,Mycobacterium tuberculosis,Infectious Disease,Drug Discovery | |
| BMD_011,2022,CRISPR/Cas9 Correction of Dystrophin Gene Mutation in Muscle Stem Cells,The causative mutation in the DMD gene was successfully corrected in patient-derived induced pluripotent stem cell (iPSC) lines using base editing. Potential for autologous cell therapy explored.,CRISPR/Cas9; Base Editing; iPSC; Muscle Stem Cells,Homo sapiens,Genetics,Therapeutic Intervention | |
| BMD_012,2024,Radiomics Signatures for Early Prediction of Response to Immunotherapy in Lung Cancer,Extraction of quantitative features from baseline CT scans predicted objective response rate to PD-1 inhibitors with high AUC in non-small cell lung cancer patients.,Radiomics; CT Imaging; Immunotherapy; Predictive Marker,Homo sapiens,Pulmonology,Diagnostic/Imaging | |
| BMD_013,2023,Functional Characterization of a New Chemokine Receptor in Allergic Asthma,Deletion of the novel receptor in a murine model of asthma reduced airway hyperresponsiveness and eosinophil infiltration. Signaling pathways downstream of the receptor were elucidated.,Knockout Mouse; Chemokine Receptor; ELISA; Airway Inflammation,Mus musculus,Immunology,Molecular Mechanism | |
| BMD_014,2022,Mass Spectrometry-Based Proteomics of Human Tear Fluid in Dry Eye Syndrome,Differential proteomics revealed 45 proteins significantly altered in the tear film of patients with severe dry eye compared to controls. Focus on inflammation and mucin production.,Proteomics; Mass Spectrometry; Tear Film Analysis; LC-MS/MS,Homo sapiens,Ophthalmology,Genomics/Proteomics | |
| BMD_015,2024,Biofabrication of Vascularized 3D Cardiac Tissue Models,Using a bioprinting approach with iPSC-derived cardiomyocytes and endothelial cells, we generated functional, perfusable cardiac microtissues exhibiting physiological contraction and electrophysiology.,Bioprinting; iPSC-Derived Cells; 3D Culture; Tissue Engineering,In Vitro,Cardiology,Cellular Processes | |
| BMD_016,2023,Impact of Mediterranean Diet on Gut Microbiota Diversity in Elderly,A randomized controlled trial demonstrated a significant increase in beneficial microbial diversity and SCFA production after 12 weeks of adherence to a Mediterranean diet in participants over 65.,Randomized Control Trial; Gut Microbiota; 16S rRNA Sequencing; SCFA,Homo sapiens,Nutrition,Epidemiology | |
| BMD_017,2022,Inhibition of Telomerase Reverse Transcriptase Reduces Malignant Pleural Mesothelioma Cell Growth,Small molecule inhibition of TERT in mesothelioma cell lines resulted in telomere shortening and induction of apoptosis, suggesting a viable therapeutic approach.,Small Molecule Inhibitor; Telomerase; Apoptosis; In Vitro,Homo sapiens,Oncology,Drug Discovery | |
| BMD_018,2024,Optogenetic Control of Dopaminergic Neuron Activity in Awake Mice,A channelrhodopsin variant was expressed specifically in VTA dopaminergic neurons to manipulate reward-seeking behavior in real-time. Fiber photometry recorded calcium dynamics.,Optogenetics; Fiber Photometry; In Vivo; Behavioral Assay,Mus musculus,Neuroscience,Molecular Mechanism | |
| BMD_019,2023,Genomic Risk Score for Type 2 Diabetes Based on East Asian Populations,Development and validation of a polygenic risk score (PRS) utilizing GWAS data from Chinese and Korean cohorts demonstrated high predictive power for T2D incidence.,GWAS; Polygenic Risk Score; Cohort Study; Statistical Genetics,Homo sapiens,Endocrinology,Genomics/Proteomics | |
| BMD_020,2022,Mechanisms of Pathogen Recognition by Plant NLR Immune Receptors,Structural and biochemical analysis of the activation mechanism of a key plant nucleotide-binding leucine-rich repeat (NLR) receptor upon recognition of a bacterial effector protein.,Protein Purification; Crystallography; Binding Assay; In Vitro,Arabidopsis thaliana,Plant Biology,Molecular Mechanism | |
| BMD_021,2024,Non-invasive Fetal ECG Extraction using Independent Component Analysis,A novel signal processing algorithm based on ICA was applied to maternal abdominal ECG recordings to reliably extract the fetal ECG signal, aiding in remote monitoring.,Signal Processing; ICA; Fetal Monitoring; Non-Invasive,Homo sapiens,Obstetrics,Diagnostic/Imaging | |
| BMD_022,2023,Long-Term Effects of Early Life Stress on Hippocampal Neurogenesis,Maternal separation in rodent models led to persistent reduction in adult hippocampal neurogenesis and deficits in spatial memory. Epigenetic changes in the dentate gyrus were observed.,Animal Model; Maternal Separation; Neurogenesis; Epigenetics,Rattus norvegicus,Neuroscience,Cellular Processes | |
| BMD_023,2022,Synthesis and Efficacy of a Dual-Action Anti-Inflammatory and Analgesic Prodrug,A novel prodrug combining a COX inhibitor and a nitric oxide donor showed superior anti-inflammatory activity and reduced gastrointestinal toxicity in preclinical models.,Medicinal Chemistry; Prodrug; In Vivo; Toxicity Assay,Mus musculus,Pharmacology,Drug Development | |
| BMD_024,2024,Single-Dose Polio Vaccine Candidates based on Virus-Like Particles (VLPs),VLPs displaying key neutralizing epitopes were designed and shown to elicit strong neutralizing antibody titers after a single immunization in non-human primates.,Virus-Like Particles; Vaccine Development; Immunization; ELISA,Macaca mulatta,Virology,Therapeutic Intervention | |
| BMD_025,2023,Transcriptional Dynamics of Reprogramming Somatic Cells to Induced Neurons,Time-course RNA sequencing captured the intermediate stages and key transcriptional hubs during the direct conversion of human fibroblasts into induced neuronal cells.,RNA Sequencing; Direct Reprogramming; Time-Course; Bioinformatics,Homo sapiens,Developmental Biology,Cellular Processes | |
| BMD_026,2022,Epidemiological Burden of Neglected Tropical Diseases in Sub-Saharan Africa,A systematic review and meta-analysis estimated the DALYs lost due to schistosomiasis and lymphatic filariasis across 15 African countries from 2010 to 2020.,Systematic Review; Meta-Analysis; DALYs; Geospatial Mapping,Homo sapiens,Public Health,Epidemiology | |
| BMD_027,2024,Leveraging Synthetic Biology for Enhanced T Cell Engagers,Engineered T cells displaying synthetic receptors targeting solid tumor antigens exhibited improved persistence and cytotoxicity in a murine xenograft model.,Synthetic Biology; T Cell Engagers; Flow Cytometry; Xenograft Model,Mus musculus,Immunology,Therapeutic Intervention | |
| BMD_028,2023,High-Resolution 3D Mapping of Cardiac Conduction System,Utilizing light-sheet microscopy and tissue clearing, a comprehensive 3D map of the atrioventricular node and His-Purkinje system was generated for the first time.,Light-Sheet Microscopy; Tissue Clearing; 3D Reconstruction; Imaging,Rattus norvegicus,Cardiology,Diagnostic/Imaging | |
| BMD_029,2022,In Silico Design and Validation of Novel Inhibitors for Mpro of COVID-19 Variants,Molecular docking and dynamics simulations identified promising small-molecule binders to the main protease (Mpro) of Omicron and Delta variants, followed by in vitro validation.,Molecular Docking; Molecular Dynamics; In Silico; Enzymatic Assay,In Vitro,Computational Biology,Drug Discovery | |
| BMD_030,2024,Protective Efficacy of a Broad-Spectrum Filovirus Vaccine in Guinea Pigs,A novel mRNA vaccine targeting conserved epitopes of Ebola, Marburg, and Sudan viruses conferred 100% protection against lethal challenge in a susceptible animal model.,mRNA Vaccine; Immunization; Viral Challenge; Survival Analysis,Cavia porcellus,Virology,Therapeutic Intervention | |
| BMD_031,2023,Automated Segmentation of White Matter Lesions in MS using Deep Learning,A U-Net based convolutional neural network (CNN) achieved expert-level accuracy in segmenting periventricular and juxtacortical white matter lesions from T2-FLAIR MRI scans.,Deep Learning; U-Net; MRI Segmentation; Image Analysis,Homo sapiens,Neuro-Radiology,Diagnostic/Imaging |