drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01619 | DB09076 | 830 | 1,116 | [
"DDInter1441",
"DDInter1899"
] | Phenindamine | Umeclidinium | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
830,
24,
1116
]
],
[
[
830,
24,
849
],
[
849,
24,
1116
]
],
[
[
830,
63,
1300
],
[
1300,
24,
1116
]
],
[
[
830,
1,
537
],
[
537,
... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Haloperidol and... |
DB00372 | DB01069 | 999 | 401 | [
"DDInter1793",
"DDInter1533"
] | Thiethylperazine | Promethazine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
999,
24,
401
]
],
[
[
999,
24,
1264
],
[
1264,
63,
401
]
],
[
[
999,
24,
939
],
[
939,
24,
401
]
],
[
[
999,
23,
460
],
[
460,
6... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine... |
DB00615 | DB00741 | 690 | 167 | [
"DDInter1589",
"DDInter885"
] | Rifabutin | Hydrocortisone | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
690,
24,
167
]
],
[
[
690,
24,
1220
],
[
1220,
40,
167
]
],
[
[
690,
63,
303
],
[
303,
40,
167
]
],
[
[
690,
24,
870
],
[
870,
1... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (... |
DB00321 | DB00574 | 21 | 121 | [
"DDInter78",
"DDInter717"
] | Amitriptyline | Fenfluramine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Moderate | 1 | [
[
[
21,
24,
121
]
],
[
[
21,
24,
1670
],
[
1670,
63,
121
]
],
[
[
21,
25,
868
],
[
868,
63,
121
]
],
[
[
21,
24,
1503
],
[
1503,
24,... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
],
... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat and Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Amitriptyline may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib ... |
DB00197 | DB04855 | 1,324 | 540 | [
"DDInter1881",
"DDInter602"
] | Troglitazone | Dronedarone | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
1324,
24,
540
]
],
[
[
1324,
23,
228
],
[
228,
40,
540
]
],
[
[
1324,
24,
33
],
[
33,
40,
540
]
],
[
[
1324,
24,
466
],
[
466,
6... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dofetilide"
],
[... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Dofetilide and Dofetilide (Compound) resembles Dronedarone (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compou... |
DB00264 | DB00687 | 88 | 870 | [
"DDInter1200",
"DDInter747"
] | Metoprolol | Fludrocortisone | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
88,
24,
870
]
],
[
[
88,
24,
1220
],
[
1220,
40,
870
]
],
[
[
88,
21,
28936
],
[
28936,
60,
870
]
],
[
[
88,
23,
115
],
[
115,
6... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Metoprolol (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Fludrocortisone (Compound)
Metoprolol may cause... |
DB01087 | DB05294 | 1,520 | 1,069 | [
"DDInter1520",
"DDInter1917"
] | Primaquine | Vandetanib | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1520,
25,
1069
]
],
[
[
1520,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
1520,
21,
28900
],
[
28900,
60,
1069
]
],
[
[
1520,
62,
1247
],
[
1... | [
[
[
"Primaquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Primaquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vandeta... | Primaquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Primaquine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Vandetanib (Compound)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethox... |
DB01246 | DB06702 | 820 | 573 | [
"DDInter45",
"DDInter731"
] | Alimemazine | Fesoterodine | A phenothiazine derivative that is used as an antipruritic. | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
820,
24,
573
]
],
[
[
820,
63,
211
],
[
211,
1,
573
]
],
[
[
820,
64,
494
],
[
494,
1,
573
]
],
[
[
820,
6,
8374
],
[
8374,
45,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Alimemazine may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Fesoterodine (Compound)
Ali... |
DB00348 | DB00900 | 254 | 45 | [
"DDInter1300",
"DDInter544"
] | Nitisinone | Didanosine | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Moderate | 1 | [
[
[
254,
24,
45
]
],
[
[
254,
21,
28810
],
[
28810,
60,
45
]
],
[
[
254,
24,
1593
],
[
1593,
63,
45
]
],
[
[
254,
24,
522
],
[
522,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal pain"
],
[
"Gastrointestinal pain",
"{... | Nitisinone (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Didanosine (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases... |
DB00976 | DB12130 | 1,056 | 1,017 | [
"DDInter1758",
"DDInter1094"
] | Telithromycin | Lorlatinib | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
1056,
25,
1017
]
],
[
[
1056,
63,
608
],
[
608,
23,
1017
]
],
[
[
1056,
64,
175
],
[
175,
24,
1017
]
],
[
[
1056,
25,
976
],
[
976,
... | [
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidoc... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Telithromycin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone ma... |
DB00047 | DB00188 | 176 | 168 | [
"DDInter932",
"DDInter222"
] | Insulin glargine | Bortezomib | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Moderate | 1 | [
[
[
176,
24,
168
]
],
[
[
176,
24,
1040
],
[
1040,
62,
168
]
],
[
[
176,
24,
590
],
[
590,
63,
168
]
],
[
[
176,
63,
305
],
[
305,
2... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may cause a minor interaction that can limit clinical effects when taken with Bortezomib
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexami... |
DB01057 | DB09076 | 1,318 | 1,116 | [
"DDInter615",
"DDInter1899"
] | Echothiophate (ophthalmic) | Umeclidinium | Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inad... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1318,
24,
1116
]
],
[
[
1318,
24,
1429
],
[
1429,
24,
1116
]
],
[
[
1318,
63,
128
],
[
128,
24,
1116
]
],
[
[
1318,
24,
103
],
[
103,
... | [
[
[
"Echothiophate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Echothiophate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
],
... | Echothiophate may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Echothiophate may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium and Aclidinium may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
... |
DB00675 | DB00850 | 888 | 1,630 | [
"DDInter1744",
"DDInter1432"
] | Tamoxifen | Perphenazine | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
888,
24,
1630
]
],
[
[
888,
63,
252
],
[
252,
40,
1630
]
],
[
[
888,
74,
508
],
[
508,
40,
1630
]
],
[
[
888,
24,
673
],
[
673,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Tamoxifen (Compound) resembles Promazine (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Promazine a... |
DB09036 | DB11988 | 812 | 270 | [
"DDInter1668",
"DDInter1321"
] | Siltuximab | Ocrelizumab | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
812,
24,
270
]
],
[
[
812,
23,
1193
],
[
1193,
23,
270
]
],
[
[
812,
62,
1461
],
[
1461,
23,
270
]
],
[
[
812,
63,
134
],
[
134,
... | [
[
[
"Siltuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Siltuximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[... | Siltuximab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Siltuximab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vita... |
DB09079 | DB14723 | 1,496 | 159 | [
"DDInter1296",
"DDInter1026"
] | Nintedanib | Larotrectinib | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1496,
24,
159
]
],
[
[
1496,
24,
1375
],
[
1375,
24,
159
]
],
[
[
1496,
24,
1412
],
[
1412,
63,
159
]
],
[
[
1496,
63,
267
],
[
267,
... | [
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
[
... | Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol a... |
DB00757 | DB01142 | 1,166 | 1,264 | [
"DDInter581",
"DDInter593"
] | Dolasetron | Doxepin | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
1166,
25,
1264
]
],
[
[
1166,
64,
508
],
[
508,
24,
1264
]
],
[
[
1166,
25,
401
],
[
401,
24,
1264
]
],
[
[
1166,
6,
6017
],
[
6017,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promazine"
],
[
"Promazine",
"{u} may ca... | Dolasetron may lead to a major life threatening interaction when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Dolasetron may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate inter... |
DB06663 | DB12825 | 1,154 | 1,375 | [
"DDInter1398",
"DDInter1032"
] | Pasireotide | Lefamulin | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
1154,
25,
1375
]
],
[
[
1154,
62,
112
],
[
112,
23,
1375
]
],
[
[
1154,
24,
159
],
[
159,
63,
1375
]
],
[
[
1154,
1,
966
],
[
966,
... | [
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Pasireotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Pasireotide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and ... |
DB00843 | DB00981 | 479 | 1,528 | [
"DDInter583",
"DDInter1462"
] | Donepezil | Physostigmine | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
479,
24,
1528
]
],
[
[
479,
6,
5765
],
[
5765,
45,
1528
]
],
[
[
479,
21,
28751
],
[
28751,
60,
1528
]
],
[
[
479,
24,
1511
],
[
1511,... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Donepezil",
"{u} (Compound) binds {v} (Gene)",
"ACHE"
],
[
"ACHE",
"{u} (Gene) is bound by {v} (Compound)",
... | Donepezil (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Physostigmine (Compound)
Donepezil (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Physostigmine (Compound)
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Me... |
DB00853 | DB08913 | 1,686 | 1,186 | [
"DDInter1762",
"DDInter1561"
] | Temozolomide | Radium Ra 223 dichloride | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
1686,
24,
1186
]
],
[
[
1686,
21,
28722
],
[
28722,
60,
1186
]
],
[
[
1686,
24,
37
],
[
37,
24,
1186
]
],
[
[
1686,
63,
134
],
[
134,
... | [
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Temozolomide",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Eff... | Temozolomide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00679 | DB00916 | 684 | 112 | [
"DDInter1796",
"DDInter1202"
] | Thioridazine | Metronidazole | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
684,
23,
112
]
],
[
[
684,
6,
3486
],
[
3486,
45,
112
]
],
[
[
684,
21,
28692
],
[
28692,
60,
112
]
],
[
[
684,
64,
618
],
[
618,
... | [
[
[
"Thioridazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Thioridazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compou... | Thioridazine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Metronidazole (Compound)
Thioridazine (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Metronidazole (Compound)
Thioridazine may lead to a major life threatening interaction when taken with Abarelix a... |
DB00635 | DB01009 | 1,573 | 935 | [
"DDInter1515",
"DDInter1009"
] | Prednisone | Ketoprofen | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
1573,
24,
935
]
],
[
[
1573,
63,
1523
],
[
1523,
40,
935
]
],
[
[
1573,
24,
1274
],
[
1274,
24,
935
]
],
[
[
1573,
24,
1263
],
[
1263,... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ketoprofen (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that cou... |
DB08882 | DB14730 | 1,281 | 1,412 | [
"DDInter1070",
"DDInter264"
] | Linagliptin | Calaspargase pegol | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1281,
24,
1412
]
],
[
[
1281,
63,
1144
],
[
1144,
24,
1412
]
],
[
[
1281,
40,
1002
],
[
1002,
24,
1412
]
],
[
[
1281,
24,
1019
],
[
10... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Linagliptin (Compound) resembles Alogliptin (Compound) and Alogliptin may cause a moderate interactio... |
DB00615 | DB06616 | 690 | 594 | [
"DDInter1589",
"DDInter224"
] | Rifabutin | Bosutinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
690,
25,
594
]
],
[
[
690,
63,
883
],
[
883,
1,
594
]
],
[
[
690,
6,
8374
],
[
8374,
45,
594
]
],
[
[
690,
7,
3727
],
[
3727,
46... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitinib",
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Rifabutin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Rifabutin (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulate... |
DB00637 | DB05381 | 1,557 | 172 | [
"DDInter128",
"DDInter863"
] | Astemizole | Histamine | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. | Moderate | 1 | [
[
[
1557,
24,
172
]
],
[
[
1557,
24,
1264
],
[
1264,
24,
172
]
],
[
[
1557,
63,
1302
],
[
1302,
24,
172
]
],
[
[
1557,
25,
851
],
[
851,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histamine"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Histamine
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyl... |
DB00284 | DB00777 | 1,647 | 146 | [
"DDInter11",
"DDInter1537"
] | Acarbose | Propiomazine | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Moderate | 1 | [
[
[
1647,
24,
146
]
],
[
[
1647,
24,
508
],
[
508,
1,
146
]
],
[
[
1647,
24,
401
],
[
401,
63,
146
]
],
[
[
1647,
24,
104
],
[
104,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Propiomazine (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could... |
DB06077 | DB09472 | 879 | 1,383 | [
"DDInter1102",
"DDInter1693"
] | Lumateperone | Sodium sulfate | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
879,
24,
1383
]
],
[
[
879,
64,
609
],
[
609,
24,
1383
]
],
[
[
879,
63,
392
],
[
392,
24,
1383
]
],
[
[
879,
24,
1250
],
[
1250,
... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
... | Lumateperone may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapati... |
DB00451 | DB06792 | 542 | 1,606 | [
"DDInter1064",
"DDInter1023"
] | Levothyroxine | Lanthanum carbonate | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
542,
24,
1606
]
],
[
[
542,
62,
88
],
[
88,
24,
1606
]
],
[
[
542,
40,
1152
],
[
1152,
24,
1606
]
],
[
[
542,
24,
1482
],
[
1482,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metoprolol"
... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Metoprolol and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Levothyroxine (Compound) resembles Liothyronine (Compound) and Liothyronine may cause a moderate inter... |
DB00911 | DB12887 | 458 | 1,598 | [
"DDInter1811",
"DDInter1750"
] | Tinidazole | Tazemetostat | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
458,
24,
1598
]
],
[
[
458,
63,
168
],
[
168,
23,
1598
]
],
[
[
458,
24,
310
],
[
310,
24,
1598
]
],
[
[
458,
63,
134
],
[
134,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Tazemetostat
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabaz... |
DB00491 | DB14509 | 127 | 1,399 | [
"DDInter1217",
"DDInter1081"
] | Miglitol | Lithium carbonate | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
127,
24,
1399
]
],
[
[
127,
24,
874
],
[
874,
23,
1399
]
],
[
[
127,
63,
1636
],
[
1636,
23,
1399
]
],
[
[
127,
24,
820
],
[
820,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and ... |
DB11186 | DB11632 | 1,609 | 580 | [
"DDInter1427",
"DDInter1343"
] | Pentoxyverine | Opicapone | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant, and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists. Pentoxyverine acts on sigma-1... | Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) in... | Moderate | 1 | [
[
[
1609,
24,
580
]
],
[
[
1609,
63,
104
],
[
104,
24,
580
]
],
[
[
1609,
64,
1053
],
[
1053,
25,
580
]
],
[
[
1609,
63,
104
],
[
104,
... | [
[
[
"Pentoxyverine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opicapone"
]
],
[
[
"Pentoxyverine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Opicapone
Pentoxyverine may lead to a major life threatening interaction when taken with Procarbazine and Procarbazi... |
DB00207 | DB01024 | 1,570 | 1,096 | [
"DDInter157",
"DDInter1252"
] | Azithromycin | Mycophenolic acid | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
1570,
24,
1096
]
],
[
[
1570,
18,
7380
],
[
7380,
46,
1096
]
],
[
[
1570,
7,
17513
],
[
17513,
46,
1096
]
],
[
[
1570,
18,
4187
],
[
4... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Azithromycin",
"{u} (Compound) downregulates {v} (Gene)",
"AKAP8L"
],
[
"AKAP8L",
"{u} (Gene) is upregu... | Azithromycin (Compound) downregulates AKAP8L (Gene) and AKAP8L (Gene) is upregulated by Mycophenolic acid (Compound)
Azithromycin (Compound) upregulates SLC35A1 (Gene) and SLC35A1 (Gene) is upregulated by Mycophenolic acid (Compound)
Azithromycin (Compound) downregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is downregul... |
DB00771 | DB01136 | 262 | 772 | [
"DDInter397",
"DDInter305"
] | Clidinium | Carvedilol | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
262,
24,
772
]
],
[
[
262,
63,
475
],
[
475,
24,
772
]
],
[
[
262,
24,
104
],
[
104,
24,
772
]
],
[
[
262,
24,
1264
],
[
1264,
6... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol
Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazi... |
DB00030 | DB06343 | 1,685 | 1,379 | [
"DDInter934",
"DDInter1766"
] | Insulin human | Teprotumumab | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by th... | Moderate | 1 | [
[
[
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[
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[
[
1685,
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[
959,
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[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teprotumumab"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Teprotumumab
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin a... |
DB08816 | DB12301 | 578 | 907 | [
"DDInter1802",
"DDInter585"
] | Ticagrelor | Doravirine | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Minor | 0 | [
[
[
578,
23,
907
]
],
[
[
578,
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1478
],
[
1478,
23,
907
]
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[
[
578,
24,
159
],
[
159,
62,
907
]
],
[
[
578,
64,
1213
],
[
1213,
... | [
[
[
"Ticagrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
]
],
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotre... |
DB06709 | DB11640 | 592 | 1,267 | [
"DDInter1165",
"DDInter64"
] | Methacholine | Amifampridine | Asthma is a complex condition associated with phenomena such as airway hyperresponsiveness (AHR), in which the smooth muscle in the airways (ASM) excessively contracts in response to stimuli, reducing pulmonary function and causing symptoms such as difficulty breathing.[A229598, A229603] Although the underlying patholo... | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscul... | Moderate | 1 | [
[
[
592,
24,
1267
]
],
[
[
592,
1,
427
],
[
427,
63,
61
],
[
61,
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]
],
[
[
592,
6,
4304
],
[
4304,
45,
401
],
[
401,
24,
1... | [
[
[
"Methacholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifampridine"
]
],
[
[
"Methacholine",
"{u} (Compound) resembles {v} (Compound)",
"Bethanechol"
],
[
"Bethanechol",
"{u} may cause ... | Methacholine (Compound) resembles Bethanechol (Compound) and Bethanechol may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium and Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine
Methacholine (Compound) binds CHRM2 (Gene) an... |
DB05316 | DB06595 | 749 | 1,491 | [
"DDInter1467",
"DDInter1214"
] | Pimavanserin | Midostaurin | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
749,
24,
1491
]
],
[
[
749,
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],
[
112,
23,
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]
],
[
[
749,
63,
888
],
[
888,
24,
1491
]
],
[
[
749,
24,
1017
],
[
1017,
... | [
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Pimavanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Pimavanserin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and ... |
DB00188 | DB00418 | 168 | 536 | [
"DDInter222",
"DDInter1650"
] | Bortezomib | Secobarbital | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Minor | 0 | [
[
[
168,
23,
536
]
],
[
[
168,
23,
1023
],
[
1023,
1,
536
]
],
[
[
168,
25,
697
],
[
697,
1,
536
]
],
[
[
168,
6,
3486
],
[
3486,
45... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Secobarbital"
]
],
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pentobarbital"
],
[
... | Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pentobarbital and Pentobarbital (Compound) resembles Secobarbital (Compound)
Bortezomib may lead to a major life threatening interaction when taken with Phenobarbital and Phenobarbital (Compound) resembles Secobarbital (Compound)
B... |
DB00675 | DB09228 | 888 | 687 | [
"DDInter1744",
"DDInter437"
] | Tamoxifen | Conestat alfa | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibi... | Moderate | 1 | [
[
[
888,
24,
687
]
],
[
[
888,
75,
11
],
[
11,
24,
687
]
],
[
[
888,
35,
1423
],
[
1423,
24,
687
]
],
[
[
888,
25,
350
],
[
350,
25,... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conestat alfa"
]
],
[
[
"Tamoxifen",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
... | Tamoxifen (Compound) resembles Toremifene (Compound) and Tamoxifen may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Tamoxifen (Compound) resembles Ospemifene (Compound) and Tamoxifen m... |
DB00026 | DB00445 | 1,184 | 322 | [
"DDInter94",
"DDInter655"
] | Anakinra | Epirubicin | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
1184,
24,
322
]
],
[
[
1184,
24,
1307
],
[
1307,
62,
322
]
],
[
[
1184,
24,
1648
],
[
1648,
24,
322
]
],
[
[
1184,
24,
1224
],
[
1224,... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
[
"... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan may cause a minor interaction that can limit clinical effects when taken with Epirubicin
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin m... |
DB00182 | DB08824 | 80 | 591 | [
"DDInter84",
"DDInter959"
] | Amphetamine | Ioflupane I-123 | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
80,
24,
591
]
],
[
[
80,
6,
2437
],
[
2437,
45,
591
]
],
[
[
80,
21,
28722
],
[
28722,
60,
591
]
],
[
[
80,
24,
401
],
[
401,
24... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Amphetamine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A3"
],
[
"SLC6A3",
"{u} (Gene) is bound by {v} (Comp... | Amphetamine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Ioflupane I-123 (Compound)
Amphetamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ioflupane I-123 (Compound)
Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine... |
DB00501 | DB01319 | 752 | 34 | [
"DDInter380",
"DDInter777"
] | Cimetidine | Fosamprenavir | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
752,
24,
34
]
],
[
[
752,
23,
1091
],
[
1091,
40,
34
]
],
[
[
752,
6,
8374
],
[
8374,
45,
34
]
],
[
[
752,
21,
29062
],
[
29062,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amprenavir"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Cimetidine (Compound) causes Neutropenia (Side Effect) and Neu... |
DB01105 | DB06779 | 222 | 365 | [
"DDInter1665",
"DDInter470"
] | Sibutramine | Dalteparin | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
222,
24,
365
]
],
[
[
222,
64,
1100
],
[
1100,
24,
365
]
],
[
[
222,
25,
1427
],
[
1427,
63,
365
]
],
[
[
222,
25,
1039
],
[
1039,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venlafaxine"
],
[
"Venlafa... | Sibutramine may lead to a major life threatening interaction when taken with Venlafaxine and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Sibutramine may lead to a major life threatening interaction when taken with Vortioxetine and Vortioxetine may cause a moder... |
DB00762 | DB01110 | 613 | 86 | [
"DDInter973",
"DDInter1209"
] | Irinotecan | Miconazole | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
613,
24,
86
]
],
[
[
613,
6,
7603
],
[
7603,
45,
86
]
],
[
[
613,
7,
2067
],
[
2067,
46,
86
]
],
[
[
613,
18,
2183
],
[
2183,
57... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Irinotecan",
"{u} (Compound) binds {v} (Gene)",
"CYP2B6"
],
[
"CYP2B6",
"{u} (Gene) is bound by {v} (Compound)",... | Irinotecan (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Miconazole (Compound)
Irinotecan (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Miconazole (Compound)
Irinotecan (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Miconazole (Compound)
Irinotecan (Co... |
DB01324 | DB09472 | 178 | 1,383 | [
"DDInter1490",
"DDInter1693"
] | Polythiazide | Sodium sulfate | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
178,
24,
1383
]
],
[
[
178,
1,
674
],
[
674,
24,
1383
]
],
[
[
178,
63,
104
],
[
104,
24,
1383
]
],
[
[
178,
24,
407
],
[
407,
6... | [
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Polythiazide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlormethiazide",
... | Polythiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a mod... |
DB05679 | DB12674 | 1,683 | 975 | [
"DDInter1907",
"DDInter1105"
] | Ustekinumab | Lurbinectedin | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
1683,
24,
975
]
],
[
[
1683,
63,
1488
],
[
1488,
24,
975
]
],
[
[
1683,
25,
980
],
[
980,
24,
975
]
],
[
[
1683,
24,
1362
],
[
1362,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Ustekinumab may lead to a major life threatening interaction when taken with Tocilizumab and Tocilizumab m... |
DB00641 | DB11569 | 467 | 1,093 | [
"DDInter1675",
"DDInter1003"
] | Simvastatin | Ixekizumab | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
467,
24,
1093
]
],
[
[
467,
63,
134
],
[
134,
24,
1093
]
],
[
[
467,
24,
1683
],
[
1683,
24,
1093
]
],
[
[
467,
64,
376
],
[
376,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
[... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and U... |
DB09065 | DB11760 | 760 | 119 | [
"DDInter424",
"DDInter1742"
] | Cobicistat | Talazoparib | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
760,
24,
119
]
],
[
[
760,
64,
1449
],
[
1449,
24,
119
]
],
[
[
760,
63,
441
],
[
441,
24,
119
]
],
[
[
760,
25,
985
],
[
985,
2... | [
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Simeprevir"
],
[
"Simeprevi... | Cobicistat may lead to a major life threatening interaction when taken with Simeprevir and Simeprevir may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Delavirdine and Delavirdine may cau... |
DB00563 | DB05273 | 663 | 507 | [
"DDInter1174",
"DDInter1638"
] | Methotrexate | Samarium (153Sm) lexidronam | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
663,
25,
507
]
],
[
[
663,
24,
248
],
[
248,
24,
507
]
],
[
[
663,
24,
270
],
[
270,
63,
507
]
],
[
[
663,
63,
1101
],
[
1101,
2... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Methotrexate may cause a moderate interaction that could exacerbate diseases when tak... |
DB00261 | DB00674 | 702 | 1,516 | [
"DDInter93",
"DDInter802"
] | Anagrelide | Galantamine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Moderate | 1 | [
[
[
702,
24,
1516
]
],
[
[
702,
21,
28766
],
[
28766,
60,
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[
[
702,
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618
],
[
618,
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]
],
[
[
702,
24,
688
],
[
688,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Galantamine"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Hypotension"
],
[
"Hypotension",
"{u} (Side Effect) is... | Anagrelide (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Galantamine (Compound)
Anagrelide may lead to a major life threatening interaction when taken with Abarelix and Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Galantamine
Anagrelid... |
DB00352 | DB00363 | 482 | 695 | [
"DDInter1814",
"DDInter419"
] | Tioguanine | Clozapine | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
482,
25,
695
]
],
[
[
482,
24,
1387
],
[
1387,
63,
695
]
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[
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482,
63,
1647
],
[
1647,
24,
695
]
],
[
[
482,
24,
1480
],
[
1480,
... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
],
[
"Terbinafin... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Terbinafine and Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbos... |
DB11730 | DB11921 | 351 | 1,019 | [
"DDInter1588",
"DDInter492"
] | Ribociclib | Deflazacort | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
351,
25,
1019
]
],
[
[
351,
63,
1072
],
[
1072,
23,
1019
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],
[
[
351,
24,
270
],
[
270,
63,
1019
]
],
[
[
351,
25,
1619
],
[
1619,
... | [
[
[
"Ribociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
[
"Isoniazid"... | Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizu... |
DB00279 | DB01124 | 1,152 | 1,411 | [
"DDInter1074",
"DDInter1828"
] | Liothyronine | Tolbutamide | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1152,
24,
1411
]
],
[
[
1152,
24,
959
],
[
959,
40,
1411
]
],
[
[
1152,
63,
245
],
[
245,
40,
1411
]
],
[
[
1152,
6,
6648
],
[
6648,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Comp... |
DB00414 | DB00460 | 590 | 612 | [
"DDInter16",
"DDInter1929"
] | Acetohexamide | Verteporfin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Moderate | 1 | [
[
[
590,
24,
612
]
],
[
[
590,
24,
1512
],
[
1512,
63,
612
]
],
[
[
590,
63,
1101
],
[
1101,
24,
612
]
],
[
[
590,
24,
640
],
[
640,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Verteporfin
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and... |
DB00308 | DB00757 | 347 | 1,166 | [
"DDInter901",
"DDInter581"
] | Ibutilide | Dolasetron | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
347,
25,
1166
]
],
[
[
347,
21,
28827
],
[
28827,
60,
1166
]
],
[
[
347,
23,
112
],
[
112,
62,
1166
]
],
[
[
347,
24,
688
],
[
688,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Ibutilide",
"{u} (Compound) causes {v} (Side Effect)",
"Orthostatic hypotension"
],
[
"Orthostatic hypotension",
"{u} (Side Effe... | Ibutilide (Compound) causes Orthostatic hypotension (Side Effect) and Orthostatic hypotension (Side Effect) is caused by Dolasetron (Compound)
Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical eff... |
DB00808 | DB01309 | 1,605 | 1,254 | [
"DDInter916",
"DDInter933"
] | Indapamide | Insulin glulisine | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1605,
24,
1254
]
],
[
[
1605,
23,
1669
],
[
1669,
24,
1254
]
],
[
[
1605,
62,
1545
],
[
1545,
24,
1254
]
],
[
[
1605,
63,
167
],
[
167... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Indapamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Minocycline"
],
... | Indapamide may cause a minor interaction that can limit clinical effects when taken with Minocycline and Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Indapamide may cause a minor interaction that can limit clinical effects when taken with Oxytetracycline ... |
DB01159 | DB09054 | 419 | 384 | [
"DDInter854",
"DDInter905"
] | Halothane | Idelalisib | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
419,
24,
384
]
],
[
[
419,
25,
1618
],
[
1618,
24,
384
]
],
[
[
419,
63,
888
],
[
888,
24,
384
]
],
[
[
419,
24,
1228
],
[
1228,
... | [
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Halothane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabozantin... | Halothane may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause ... |
DB00495 | DB01254 | 139 | 1,213 | [
"DDInter1961",
"DDInter484"
] | Zidovudine | Dasatinib | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
139,
24,
1213
]
],
[
[
139,
6,
17404
],
[
17404,
45,
1213
]
],
[
[
139,
6,
8155
],
[
8155,
46,
1213
]
],
[
[
139,
21,
28882
],
[
28882... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Zidovudine",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Zidovudine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound)
Zidovudine (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is upregulated by Dasatinib (Compound)
Zidovudine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasa... |
DB00285 | DB12130 | 1,100 | 1,017 | [
"DDInter1927",
"DDInter1094"
] | Venlafaxine | Lorlatinib | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1100,
24,
1017
]
],
[
[
1100,
24,
1421
],
[
1421,
63,
1017
]
],
[
[
1100,
24,
1491
],
[
1491,
24,
1017
]
],
[
[
1100,
25,
11
],
[
11,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
],
[
... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban and Betrixaban may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Mid... |
DB00757 | DB05316 | 1,166 | 749 | [
"DDInter581",
"DDInter1467"
] | Dolasetron | Pimavanserin | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Major | 2 | [
[
[
1166,
25,
749
]
],
[
[
1166,
23,
112
],
[
112,
23,
749
]
],
[
[
1166,
25,
1264
],
[
1264,
24,
749
]
],
[
[
1166,
64,
521
],
[
521,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimavanserin"
]
],
[
[
"Dolasetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Dolasetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimavanserin
Dolasetron may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a ... |
DB00029 | DB00790 | 25 | 664 | [
"DDInter99",
"DDInter1431"
] | Anistreplase | Perindopril | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Moderate | 1 | [
[
[
25,
24,
664
]
],
[
[
25,
24,
1638
],
[
1638,
1,
664
]
],
[
[
25,
24,
954
],
[
954,
40,
664
]
],
[
[
25,
24,
885
],
[
885,
63,
... | [
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perindopril"
]
],
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
... | Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Perindopril (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Perindopril (Co... |
DB00376 | DB00981 | 1,105 | 1,528 | [
"DDInter1870",
"DDInter1462"
] | Trihexyphenidyl | Physostigmine | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
1105,
24,
1528
]
],
[
[
1105,
21,
28658
],
[
28658,
60,
1528
]
],
[
[
1105,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
1105,
24,
543
],
[
5... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Trihexyphenidyl",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effe... | Trihexyphenidyl (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Physostigmine (Compound)
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken... |
DB00490 | DB00574 | 946 | 121 | [
"DDInter254",
"DDInter717"
] | Buspirone | Fenfluramine | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Major | 2 | [
[
[
946,
25,
121
]
],
[
[
946,
24,
868
],
[
868,
63,
121
]
],
[
[
946,
25,
1264
],
[
1264,
63,
121
]
],
[
[
946,
63,
1324
],
[
1324,
... | [
[
[
"Buspirone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
]
],
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
"Vemurafen... | Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Buspirone may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a mo... |
DB11730 | DB11988 | 351 | 270 | [
"DDInter1588",
"DDInter1321"
] | Ribociclib | Ocrelizumab | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
351,
24,
270
]
],
[
[
351,
24,
1060
],
[
1060,
63,
270
]
],
[
[
351,
63,
134
],
[
134,
24,
270
]
],
[
[
351,
25,
1019
],
[
1019,
... | [
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
],... | Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enfortumab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Vino... |
DB00489 | DB06589 | 17 | 1,250 | [
"DDInter1704",
"DDInter1400"
] | Sotalol | Pazopanib | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
17,
25,
1250
]
],
[
[
17,
21,
28658
],
[
28658,
60,
1250
]
],
[
[
17,
23,
112
],
[
112,
23,
1250
]
],
[
[
17,
25,
1151
],
[
1151,
... | [
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Sotalol",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Sotalol (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib (Compound)
Sotalol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Sota... |
DB00059 | DB00099 | 1,560 | 440 | [
"DDInter1404",
"DDInter735"
] | Pegaspargase | Filgrastim | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Moderate | 1 | [
[
[
1560,
24,
440
]
],
[
[
1560,
24,
37
],
[
37,
63,
440
]
],
[
[
1560,
25,
1101
],
[
1101,
63,
440
]
],
[
[
1560,
63,
1451
],
[
1451,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Filgrastim"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
],
[... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim
Pegaspargase may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may caus... |
DB00358 | DB14568 | 1,010 | 982 | [
"DDInter1140",
"DDInter1000"
] | Mefloquine | Ivosidenib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1010,
25,
982
]
],
[
[
1010,
23,
112
],
[
112,
23,
982
]
],
[
[
1010,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1010,
24,
1081
],
[
1081,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexa... |
DB01059 | DB11126 | 956 | 900 | [
"DDInter1313",
"DDInter276"
] | Norfloxacin | Calcium gluconate | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
956,
24,
900
]
],
[
[
956,
40,
1176
],
[
1176,
24,
900
]
],
[
[
956,
1,
872
],
[
872,
24,
900
]
],
[
[
956,
40,
1176
],
[
1176,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Norfloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u} may ca... | Norfloxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Norfloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken... |
DB00357 | DB01259 | 1,051 | 392 | [
"DDInter71",
"DDInter1024"
] | Aminoglutethimide | Lapatinib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1051,
24,
392
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
392
]
],
[
[
1051,
18,
5795
],
[
5795,
46,
392
]
],
[
[
1051,
21,
29539
],
[
29539... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v}... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Aminoglutethimide (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Lapatinib (Compound)
Aminoglutethimide (Compound) causes Hepatotoxicity (Side Effect) and Hepatotoxicity (Side Effect) is caused ... |
DB08916 | DB11730 | 26 | 351 | [
"DDInter32",
"DDInter1588"
] | Afatinib | Ribociclib | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
26,
24,
351
]
],
[
[
26,
24,
466
],
[
466,
62,
351
]
],
[
[
26,
24,
1627
],
[
1627,
23,
351
]
],
[
[
26,
24,
861
],
[
861,
63,
... | [
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabi... |
DB00987 | DB01165 | 1,224 | 1,539 | [
"DDInter460",
"DDInter1325"
] | Cytarabine | Ofloxacin | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Minor | 0 | [
[
[
1224,
23,
1539
]
],
[
[
1224,
62,
1467
],
[
1467,
1,
1539
]
],
[
[
1224,
23,
945
],
[
945,
40,
1539
]
],
[
[
1224,
23,
246
],
[
246,
... | [
[
[
"Cytarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ofloxacin"
]
],
[
[
"Cytarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
[
"En... | Cytarabine may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Cytarabine may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Cytara... |
DB00930 | DB00959 | 166 | 1,486 | [
"DDInter432",
"DDInter1191"
] | Colesevelam | Methylprednisolone | Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in th... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
166,
24,
1486
]
],
[
[
166,
63,
175
],
[
175,
40,
1486
]
],
[
[
166,
63,
167
],
[
167,
1,
1486
]
],
[
[
166,
24,
1220
],
[
1220,
... | [
[
[
"Colesevelam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Colesevelam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Colesevelam may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Colesevelam may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resemble... |
DB00495 | DB08880 | 139 | 1,510 | [
"DDInter1961",
"DDInter1771"
] | Zidovudine | Teriflunomide | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
139,
25,
1510
]
],
[
[
139,
63,
10
],
[
10,
24,
1510
]
],
[
[
139,
24,
1430
],
[
1430,
24,
1510
]
],
[
[
139,
23,
752
],
[
752,
... | [
[
[
"Zidovudine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapsone"
],
[
"Dapsone",
... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleu... |
DB00328 | DB00775 | 831 | 1,226 | [
"DDInter921",
"DDInter1818"
] | Indomethacin | Tirofiban | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Moderate | 1 | [
[
[
831,
24,
1226
]
],
[
[
831,
21,
28681
],
[
28681,
60,
1226
]
],
[
[
831,
24,
714
],
[
714,
63,
1226
]
],
[
[
831,
24,
1061
],
[
1061,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tirofiban"
]
],
[
[
"Indomethacin",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Sid... | Indomethacin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Tirofiban (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken... |
DB01018 | DB08907 | 1,364 | 1,344 | [
"DDInter847",
"DDInter280"
] | Guanfacine | Canagliflozin | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1364,
24,
1344
]
],
[
[
1364,
24,
549
],
[
549,
1,
1344
]
],
[
[
1364,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
1364,
21,
28681
],
[
28681... | [
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Guanfacine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Guanfacine (Compound) causes Hypersensitivity (Side Ef... |
DB04855 | DB14568 | 540 | 982 | [
"DDInter602",
"DDInter1000"
] | Dronedarone | Ivosidenib | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
540,
25,
982
]
],
[
[
540,
62,
112
],
[
112,
23,
982
]
],
[
[
540,
63,
1101
],
[
1101,
23,
982
]
],
[
[
540,
24,
976
],
[
976,
2... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Dronedarone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Dronedarone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Be... |
DB00209 | DB06702 | 352 | 573 | [
"DDInter1886",
"DDInter731"
] | Trospium | Fesoterodine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
352,
24,
573
]
],
[
[
352,
24,
211
],
[
211,
1,
573
]
],
[
[
352,
6,
12523
],
[
12523,
45,
573
]
],
[
[
352,
21,
30997
],
[
30997,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fesoterodine (Compound)
Trospium (Compound) causes Micturition disorder (Side Effect) an... |
DB00400 | DB00980 | 353 | 969 | [
"DDInter843",
"DDInter1564"
] | Griseofulvin | Ramelteon | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Moderate | 1 | [
[
[
353,
24,
969
]
],
[
[
353,
6,
7950
],
[
7950,
45,
969
]
],
[
[
353,
21,
28714
],
[
28714,
60,
969
]
],
[
[
353,
24,
214
],
[
214,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramelteon"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound... | Griseofulvin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ramelteon (Compound)
Griseofulvin (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Ramelteon (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and ... |
DB00358 | DB00978 | 1,010 | 739 | [
"DDInter1140",
"DDInter1084"
] | Mefloquine | Lomefloxacin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Moderate | 1 | [
[
[
1010,
24,
739
]
],
[
[
1010,
25,
945
],
[
945,
40,
739
]
],
[
[
1010,
24,
872
],
[
872,
40,
739
]
],
[
[
1010,
64,
1176
],
[
1176,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Sparfl... | Mefloquine may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Lomefloxacin (Compound)
Mef... |
DB00018 | DB00682 | 199 | 126 | [
"DDInter945",
"DDInter1951"
] | Interferon alfa-n3 | Warfarin | Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD). | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
199,
24,
126
]
],
[
[
199,
25,
593
],
[
593,
63,
126
]
],
[
[
199,
24,
1683
],
[
1683,
63,
126
]
],
[
[
199,
23,
450
],
[
450,
2... | [
[
[
"Interferon alfa-n3",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Interferon alfa-n3",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
],
[
... | Interferon alfa-n3 may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Interferon alfa-n3 may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinu... |
DB01175 | DB12500 | 318 | 283 | [
"DDInter672",
"DDInter714"
] | Escitalopram | Fedratinib | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
318,
24,
283
]
],
[
[
318,
25,
351
],
[
351,
23,
283
]
],
[
[
318,
62,
1419
],
[
1419,
24,
283
]
],
[
[
318,
64,
600
],
[
600,
2... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Riboci... | Escitalopram may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Escitalopram may cause a minor interaction that can limit clinical effects when taken with Imatinib and Imatinib may cause a mo... |
DB00357 | DB00813 | 1,051 | 704 | [
"DDInter71",
"DDInter722"
] | Aminoglutethimide | Fentanyl | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Major | 2 | [
[
[
1051,
25,
704
]
],
[
[
1051,
24,
307
],
[
307,
1,
704
]
],
[
[
1051,
24,
194
],
[
194,
40,
704
]
],
[
[
1051,
64,
576
],
[
576,
... | [
[
[
"Aminoglutethimide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Fentanyl (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin and Darifenacin (Compound) resembles Fentanyl (... |
DB00790 | DB01124 | 664 | 1,411 | [
"DDInter1431",
"DDInter1828"
] | Perindopril | Tolbutamide | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
664,
24,
1411
]
],
[
[
664,
24,
959
],
[
959,
40,
1411
]
],
[
[
664,
63,
245
],
[
245,
40,
1411
]
],
[
[
664,
6,
4610
],
[
4610,
... | [
[
[
"Perindopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Perindopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compou... |
DB01234 | DB14444 | 1,220 | 151 | [
"DDInter513",
"DDInter924"
] | Dexamethasone | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1220,
24,
151
]
],
[
[
1220,
63,
66
],
[
66,
24,
151
]
],
[
[
1220,
24,
1619
],
[
1619,
24,
151
]
],
[
[
1220,
40,
1573
],
[
1573,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that c... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Dexamethasone may cause a moderate... |
DB00863 | DB06616 | 1,194 | 594 | [
"DDInter1568",
"DDInter224"
] | Ranitidine | Bosutinib | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1194,
24,
594
]
],
[
[
1194,
63,
883
],
[
883,
1,
594
]
],
[
[
1194,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1194,
18,
5833
],
[
5833,
... | [
[
[
"Ranitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Ranitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Ranitidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Ranitidine (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is u... |
DB00705 | DB08896 | 441 | 292 | [
"DDInter496",
"DDInter1576"
] | Delavirdine | Regorafenib | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
441,
24,
292
]
],
[
[
441,
6,
6017
],
[
6017,
45,
292
]
],
[
[
441,
21,
28807
],
[
28807,
60,
292
]
],
[
[
441,
25,
1135
],
[
1135,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Delavirdine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound... | Delavirdine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Delavirdine (Compound) causes Protein urine present (Side Effect) and Protein urine present (Side Effect) is caused by Regorafenib (Compound)
Delavirdine may lead to a major life threatening interaction when taken with Nalox... |
DB01215 | DB11186 | 1,418 | 1,609 | [
"DDInter677",
"DDInter1427"
] | Estazolam | Pentoxyverine | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1418,
24,
1609
]
],
[
[
1418,
24,
649
],
[
649,
24,
1609
]
],
[
[
1418,
63,
506
],
[
506,
24,
1609
]
],
[
[
1418,
40,
523
],
[
523,
... | [
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and... |
DB00727 | DB01156 | 685 | 593 | [
"DDInter1304",
"DDInter252"
] | Nitroglycerin | Bupropion | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
685,
24,
593
]
],
[
[
685,
21,
29122
],
[
29122,
60,
593
]
],
[
[
685,
24,
1376
],
[
1376,
24,
593
]
],
[
[
685,
63,
530
],
[
530,
... | [
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Nitroglycerin",
"{u} (Compound) causes {v} (Side Effect)",
"Mediastinal disorder"
],
[
"Mediastinal disorder",
... | Nitroglycerin (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Bupropion (Compound)
Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacer... |
DB00539 | DB00674 | 11 | 1,516 | [
"DDInter1837",
"DDInter802"
] | Toremifene | Galantamine | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Moderate | 1 | [
[
[
11,
24,
1516
]
],
[
[
11,
6,
8374
],
[
8374,
45,
1516
]
],
[
[
11,
18,
15501
],
[
15501,
57,
1516
]
],
[
[
11,
21,
28784
],
[
28784,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Galantamine"
]
],
[
[
"Toremifene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Toremifene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Galantamine (Compound)
Toremifene (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Galantamine (Compound)
Toremifene (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Galant... |
DB00927 | DB08864 | 1,559 | 786 | [
"DDInter712",
"DDInter1595"
] | Famotidine | Rilpivirine | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Major | 2 | [
[
[
1559,
25,
786
]
],
[
[
1559,
6,
10215
],
[
10215,
45,
786
]
],
[
[
1559,
21,
28698
],
[
28698,
60,
786
]
],
[
[
1559,
62,
112
],
[
112... | [
[
[
"Famotidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilpivirine"
]
],
[
[
"Famotidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
"Rilp... | Famotidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Rilpivirine (Compound)
Famotidine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Rilpivirine (Compound)
Famotidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and M... |
DB09322 | DB15762 | 1,114 | 725 | [
"DDInter1966",
"DDInter1644"
] | Zinc sulfate | Satralizumab | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Minor | 0 | [
[
[
1114,
23,
725
]
],
[
[
1114,
62,
629
],
[
629,
24,
725
]
],
[
[
1114,
23,
270
],
[
270,
24,
725
]
],
[
[
1114,
62,
1066
],
[
1066,
... | [
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Satralizumab"
]
],
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sirolimus"
],
[
... | Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab
Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab and Ocrel... |
DB00013 | DB00775 | 1,255 | 1,226 | [
"DDInter1905",
"DDInter1818"
] | Urokinase | Tirofiban | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Major | 2 | [
[
[
1255,
25,
1226
]
],
[
[
1255,
23,
539
],
[
539,
62,
1226
]
],
[
[
1255,
24,
714
],
[
714,
63,
1226
]
],
[
[
1255,
24,
940
],
[
940,
... | [
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tirofiban"
]
],
[
[
"Urokinase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Urokinase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Tirofiban
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause ... |
DB06372 | DB06688 | 259 | 1,430 | [
"DDInter1594",
"DDInter1677"
] | Rilonacept | Sipuleucel-T | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
259,
24,
1430
]
],
[
[
259,
63,
175
],
[
175,
24,
1430
]
],
[
[
259,
25,
676
],
[
676,
63,
1430
]
],
[
[
259,
24,
310
],
[
310,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Rilonacept may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitini... |
DB00261 | DB01182 | 702 | 371 | [
"DDInter93",
"DDInter1534"
] | Anagrelide | Propafenone | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Major | 2 | [
[
[
702,
25,
371
]
],
[
[
702,
25,
847
],
[
847,
1,
371
]
],
[
[
702,
24,
772
],
[
772,
40,
371
]
],
[
[
702,
24,
97
],
[
97,
1,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Propafenone"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Atomoxetine"
],
[
"Atomoxetine",
"{u... | Anagrelide may lead to a major life threatening interaction when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol and Carvedilol (Compound) resembles Propafenone (Compound)
Anagrelide ... |
DB00490 | DB01181 | 946 | 1,532 | [
"DDInter254",
"DDInter906"
] | Buspirone | Ifosfamide | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
946,
24,
1532
]
],
[
[
946,
6,
7524
],
[
7524,
45,
1532
]
],
[
[
946,
18,
8109
],
[
8109,
57,
1532
]
],
[
[
946,
21,
28956
],
[
28956,... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Buspirone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Buspirone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound)
Buspirone (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by Ifosfamide (Compound)
Buspirone (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Bus... |
DB01110 | DB06016 | 86 | 1,508 | [
"DDInter1209",
"DDInter300"
] | Miconazole | Cariprazine | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
86,
24,
1508
]
],
[
[
86,
24,
1593
],
[
1593,
63,
1508
]
],
[
[
86,
63,
600
],
[
600,
24,
1508
]
],
[
[
86,
24,
1213
],
[
1213,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluc... |
DB00197 | DB00363 | 1,324 | 695 | [
"DDInter1881",
"DDInter419"
] | Troglitazone | Clozapine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Moderate | 1 | [
[
[
1324,
24,
695
]
],
[
[
1324,
24,
1178
],
[
1178,
1,
695
]
],
[
[
1324,
24,
902
],
[
902,
40,
695
]
],
[
[
1324,
24,
144
],
[
144,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Clozapine (Co... |
DB00539 | DB01001 | 11 | 688 | [
"DDInter1837",
"DDInter1632"
] | Toremifene | Salbutamol | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
11,
24,
688
]
],
[
[
11,
24,
455
],
[
455,
24,
688
]
],
[
[
11,
25,
1148
],
[
1148,
63,
688
]
],
[
[
11,
6,
8374
],
[
8374,
45,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Toremifene may lead to a major life threatening interaction when taken with Isoprenaline and Isoprenaline may ca... |
DB01059 | DB01575 | 956 | 1,054 | [
"DDInter1313",
"DDInter1005"
] | Norfloxacin | Kaolin | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
956,
24,
1054
]
],
[
[
956,
40,
1176
],
[
1176,
24,
1054
]
],
[
[
956,
1,
872
],
[
872,
24,
1054
]
],
[
[
956,
25,
1487
],
[
1487,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Norfloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u} may cause a moder... | Norfloxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Norfloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Kaoli... |
DB00934 | DB09039 | 413 | 1,670 | [
"DDInter1124",
"DDInter629"
] | Maprotiline | Eliglustat | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
413,
24,
1670
]
],
[
[
413,
64,
121
],
[
121,
24,
1670
]
],
[
[
413,
63,
322
],
[
322,
24,
1670
]
],
[
[
413,
24,
272
],
[
272,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Maprotiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
],
[
"Fenflu... | Maprotiline may lead to a major life threatening interaction when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may ... |
DB00220 | DB12500 | 798 | 283 | [
"DDInter1276",
"DDInter714"
] | Nelfinavir | Fedratinib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
798,
25,
283
]
],
[
[
798,
24,
466
],
[
466,
62,
283
]
],
[
[
798,
25,
351
],
[
351,
23,
283
]
],
[
[
798,
24,
1419
],
[
1419,
2... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Daroluta... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Nelfinavir may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may caus... |
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