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README.md
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---
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license: mit
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task_categories:
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- text-classification
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tags:
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- peptide
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- mhc
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- hla
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- binding-prediction
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- immunology
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size_categories:
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- n>1M
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---
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# PM (Peptide-MHC) Binding Prediction Dataset
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## Dataset Description
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This dataset is part of the SPRINT benchmark framework for TCR-pMHC binding prediction. It contains peptide-MHC binding data for training and in-distribution testing of binding prediction models.
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### Dataset Summary
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The PM dataset focuses on peptide-MHC binding prediction without TCR information. It is reorganized and standardized from multiple sources to provide a clean benchmark for PM task evaluation.
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## Dataset Structure
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### Files
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- `train.csv`: Training data
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- `id_test.csv`: In-distribution test data
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### Data Format
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Each CSV file contains the following columns:
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| Column | Type | Description |
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|--------|------|-------------|
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| peptide | string | Peptide amino acid sequence |
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| HLA | string | HLA allele (standardized format: A*02:01) |
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| label | float | Binding affinity (continuous values) |
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| HLA_sequence | string | HLA pseudo-sequence |
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### Dataset Statistics
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**Training Set:**
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- Total samples: 2098450
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- Label type: Continuous (binding affinity)
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- Label range: 0.0000 - 1.0000
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- Unique HLAs: 112
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- Unique peptides: 1834505
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- Peptide length range: 8-14
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**Test Set (In-Distribution):**
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- Total samples: 171438
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- Label type: Continuous (binding affinity)
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- Label range: 0.0000 - 1.0000
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- Unique HLAs: 112
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- Unique peptides: 158145
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- Peptide length range: 8-14
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## Usage
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### Load with Pandas
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```python
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from huggingface_hub import hf_hub_download
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import pandas as pd
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# Download files
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train_file = hf_hub_download(
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repo_id="YYJMAY/pm-binding",
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filename="train.csv",
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repo_type="dataset"
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)
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test_file = hf_hub_download(
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repo_id="YYJMAY/pm-binding",
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filename="id_test.csv",
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repo_type="dataset"
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)
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# Load data
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train_df = pd.read_csv(train_file)
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test_df = pd.read_csv(test_file)
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```
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### Use with SPRINT Framework
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```python
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from sprint.core.dataset_manager import DatasetManager
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manager = DatasetManager()
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config = {
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'hf_repo': 'YYJMAY/pm-binding',
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'files': ['train.csv', 'id_test.csv']
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}
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files = manager.get_dataset('pm', config)
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```
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## Data Preparation
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This dataset was prepared with the following steps:
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1. **Source Integration**: Combined data from multiple PM binding datasets
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2. **HLA Standardization**: Normalized HLA allele names to A*02:01 format
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3. **Quality Control**: Removed duplicates and incomplete entries
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4. **Column Standardization**: Unified column names and formats
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5. **Validation**: Checked for data consistency and quality
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## Tasks
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This dataset is designed for:
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- **Peptide-MHC Binding Prediction**: Predicting binding affinity between peptides and MHC molecules
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- **In-Distribution Evaluation**: Testing model performance on similar data distribution as training
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- **Baseline Comparison**: Standardized data for reproducible benchmarking
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## Citation
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If you use this dataset, please cite:
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```bibtex
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@dataset{pm_dataset_2024,
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title={PM (Peptide-MHC) Binding Prediction Dataset},
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author={SPRINT Framework Contributors},
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year={2024},
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url={https://huggingface.co/datasets/YYJMAY/pm-binding}
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}
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```
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## License
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MIT License
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## Contact
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For questions or issues, please refer to the SPRINT framework repository.
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