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#!/usr/bin/env python
"""
Evaluate retrieval baselines against library indices.

Supported modes:
1) Oracle molecule-query retrieval (ChemBERTa / SMI-TED / FLARE-mol).
2) FLARE spectrum-query retrieval (query from FLARE spec encoder -> index_flare.faiss).
"""
from __future__ import annotations

import argparse
import json
import sys
from functools import lru_cache
from pathlib import Path

ROOT = Path(__file__).resolve().parents[1]
if str(ROOT) not in sys.path:
    sys.path.insert(0, str(ROOT))

import numpy as np
from tqdm import tqdm

from spec_rag.embeddings import SMILESEmbedder, l2_normalize
from spec_rag.faiss_index import load_index, index_search
from spec_rag.flare_encoder import FLAREMolEmbedder, FLARESpecEmbedder
from spec_rag.smited_encoder import load_smited_encoder


def load_meta(library_dir: Path):
    if (library_dir / "meta.parquet").exists():
        import pandas as pd
        return pd.read_parquet(library_dir / "meta.parquet")
    if (library_dir / "meta.jsonl").exists():
        rows = []
        with open(library_dir / "meta.jsonl") as f:
            for line in f:
                if line.strip():
                    rows.append(json.loads(line))
        import pandas as pd
        return pd.DataFrame(rows)
    raise FileNotFoundError(f"No meta.parquet or meta.jsonl in {library_dir}")


@lru_cache(maxsize=200000)
def canonicalize_smiles(smiles: str) -> str:
    text = str(smiles or "").strip()
    if not text:
        return ""
    try:
        from rdkit import Chem
    except ImportError:
        return text
    mol = Chem.MolFromSmiles(text)
    if mol is None:
        return text
    return Chem.MolToSmiles(mol, canonical=True)


def recall_at_k(indices: list, meta_df, gt_smiles: str, k: int) -> bool:
    if not gt_smiles or not indices or meta_df is None:
        return False
    gt_canon = canonicalize_smiles(gt_smiles)
    for i in indices[:k]:
        if i < len(meta_df) and canonicalize_smiles(meta_df.iloc[i]["smiles"]) == gt_canon:
            return True
    return False


def tanimoto_at_1(top_smiles: str, gt_smiles: str) -> float | None:
    try:
        from rdkit import Chem
        from rdkit.Chem import DataStructs
        from rdkit.Chem.AllChem import GetMorganFingerprintAsBitVect
    except ImportError:
        return None
    if not top_smiles or not gt_smiles:
        return None
    mol_gt = Chem.MolFromSmiles(gt_smiles)
    mol_pred = Chem.MolFromSmiles(top_smiles)
    if mol_gt is None or mol_pred is None:
        return None
    fp_gt = GetMorganFingerprintAsBitVect(mol_gt, 2, nBits=2048)
    fp_pred = GetMorganFingerprintAsBitVect(mol_pred, 2, nBits=2048)
    return DataStructs.TanimotoSimilarity(fp_gt, fp_pred)


def parse_args():
    p = argparse.ArgumentParser(description="Evaluate retrieval baselines against library indices")
    p.add_argument("--pred-jsonl", required=True, help="JSONL from retrieve_generate (has smiles_gt per line)")
    p.add_argument("--library-dir", required=True, help="Library with index_chem.faiss, index_smi.faiss, meta")
    p.add_argument("--despecbridge-path", default=None, help="De-SpecBridge path for SMI-TED encoder")
    p.add_argument("--chemberta-model", default="Derify/ChemBERTa_augmented_pubchem_13m")
    p.add_argument("--flare-repo", default=str(ROOT / "FLARE"))
    p.add_argument("--flare-hparams", default=str(ROOT / "FLARE" / "experiments" / "20250913_optimized_filip-model" / "lightning_logs" / "version_0" / "hparams.yaml"))
    p.add_argument("--flare-checkpoint", default=str(ROOT / "FLARE" / "pretrained_models" / "flare.ckpt"))
    p.add_argument("--flare-batch-size", type=int, default=256)
    p.add_argument("--with-flare-oracle", action="store_true", help="Run oracle retrieval using FLARE mol encoder + index_flare")
    p.add_argument("--spec-tsv", default=None, help="TSV with spectra rows (for FLARE spec encoder eval)")
    p.add_argument("--subformula-dir", default=None, help="Subformula directory for FLARE spec encoder eval")
    p.add_argument("--spec-fold", default="test", help="Fold to evaluate in --spec-tsv (default: test)")
    p.add_argument("--with-flare-spec", action="store_true", help="Run FLARE spectrum-encoder retrieval + index_flare")
    p.add_argument("--K", type=int, default=100)
    p.add_argument("--batch-size", type=int, default=64)
    p.add_argument("--report", default=None, help="Write metrics JSON here")
    p.add_argument("--device", default="cuda")
    return p.parse_args()


def main():
    args = parse_args()
    library_dir = Path(args.library_dir)
    meta_df = load_meta(library_dir)

    rows = []
    with open(args.pred_jsonl) as f:
        for line in f:
            if line.strip():
                rows.append(json.loads(line))
    smiles_gt_list = [r.get("smiles_gt", "") for r in rows]
    n = len(smiles_gt_list)
    if n == 0:
        raise SystemExit("No rows in pred-jsonl")

    index_chem = load_index(library_dir / "index_chem.faiss") if (library_dir / "index_chem.faiss").exists() else None
    index_smi = load_index(library_dir / "index_smi.faiss") if (library_dir / "index_smi.faiss").exists() else None
    index_flare = load_index(library_dir / "index_flare.faiss") if (library_dir / "index_flare.faiss").exists() else None

    device = args.device
    if device == "cuda":
        try:
            import torch
            if not torch.cuda.is_available():
                device = "cpu"
        except Exception:
            device = "cpu"

    q_chem = None
    if index_chem is not None:
        print("Encoding test SMILES with ChemBERTa...")
        embedder_chem = SMILESEmbedder(
            model_name=args.chemberta_model,
            device=device,
            batch_size=args.batch_size,
            normalize=False,
        )
        q_chem = embedder_chem.encode(smiles_gt_list)
        q_chem = l2_normalize(q_chem).astype(np.float32)

    q_smi = None
    if index_smi is not None:
        encode_smi = load_smited_encoder(despecbridge_path=args.despecbridge_path, device=device)
        if encode_smi is None:
            print("SMI-TED not available; skipping oracle_smi metrics.")
        else:
            print("Encoding test SMILES with SMI-TED...")
            q_smi = encode_smi(smiles_gt_list, batch_size=args.batch_size)
            q_smi = l2_normalize(q_smi).astype(np.float32)

    K = args.K
    results_chem = {"r1": 0, "r10": 0, "r50": 0, "tan": []}
    results_smi = {"r1": 0, "r10": 0, "r50": 0, "tan": []}

    if q_chem is not None and index_chem is not None:
        scores_chem, indices_chem = index_search(index_chem, q_chem, K)
        for i in range(n):
            idx_list = indices_chem[i].tolist()
            gt = smiles_gt_list[i]
            if recall_at_k(idx_list, meta_df, gt, 1):
                results_chem["r1"] += 1
            if recall_at_k(idx_list, meta_df, gt, 10):
                results_chem["r10"] += 1
            if recall_at_k(idx_list, meta_df, gt, 50):
                results_chem["r50"] += 1
            if idx_list and idx_list[0] < len(meta_df):
                top_smi = meta_df.iloc[idx_list[0]]["smiles"]
                t = tanimoto_at_1(top_smi, gt)
                if t is not None:
                    results_chem["tan"].append(t)

    # SMI-TED oracle
    if q_smi is not None and index_smi is not None:
        scores_smi, indices_smi = index_search(index_smi, q_smi, K)
        for i in range(n):
            idx_list = indices_smi[i].tolist()
            gt = smiles_gt_list[i]
            if recall_at_k(idx_list, meta_df, gt, 1):
                results_smi["r1"] += 1
            if recall_at_k(idx_list, meta_df, gt, 10):
                results_smi["r10"] += 1
            if recall_at_k(idx_list, meta_df, gt, 50):
                results_smi["r50"] += 1
            if idx_list and idx_list[0] < len(meta_df):
                top_smi = meta_df.iloc[idx_list[0]]["smiles"]
                t = tanimoto_at_1(top_smi, gt)
                if t is not None:
                    results_smi["tan"].append(t)

    metrics = {
        "n": n,
        "K": K,
        "oracle_chem": None,
        "oracle_smi": None,
        "oracle_flare": None,
        "flare_spec_query": None,
    }
    if q_chem is not None and index_chem is not None:
        metrics["oracle_chem"] = {
            "Recall@1": results_chem["r1"] / n,
            "Recall@10": results_chem["r10"] / n,
            "Recall@50": results_chem["r50"] / n,
            "Tanimoto@1_mean": sum(results_chem["tan"]) / len(results_chem["tan"]) if results_chem["tan"] else None,
        }
    if q_smi is not None:
        metrics["oracle_smi"] = {
            "Recall@1": results_smi["r1"] / n,
            "Recall@10": results_smi["r10"] / n,
            "Recall@50": results_smi["r50"] / n,
            "Tanimoto@1_mean": sum(results_smi["tan"]) / len(results_smi["tan"]) if results_smi["tan"] else None,
        }

    if args.with_flare_oracle:
        if index_flare is None:
            print("index_flare.faiss not found; skipping oracle_flare.")
        else:
            print("Encoding test SMILES with FLARE mol encoder...")
            flare_mol = FLAREMolEmbedder(
                flare_repo=args.flare_repo,
                hparams_pth=args.flare_hparams,
                checkpoint_pth=args.flare_checkpoint,
                device=device,
                batch_size=args.flare_batch_size,
                normalize=True,
            )
            q_flare = flare_mol.encode(smiles_gt_list).astype(np.float32)
            scores_flare, indices_flare = index_search(index_flare, q_flare, K)
            results_flare = {"r1": 0, "r10": 0, "r50": 0, "tan": []}
            for i in range(n):
                idx_list = indices_flare[i].tolist()
                gt = smiles_gt_list[i]
                if recall_at_k(idx_list, meta_df, gt, 1):
                    results_flare["r1"] += 1
                if recall_at_k(idx_list, meta_df, gt, 10):
                    results_flare["r10"] += 1
                if recall_at_k(idx_list, meta_df, gt, 50):
                    results_flare["r50"] += 1
                if idx_list and idx_list[0] < len(meta_df):
                    top_smi = meta_df.iloc[idx_list[0]]["smiles"]
                    t = tanimoto_at_1(top_smi, gt)
                    if t is not None:
                        results_flare["tan"].append(t)
            metrics["oracle_flare"] = {
                "Recall@1": results_flare["r1"] / n,
                "Recall@10": results_flare["r10"] / n,
                "Recall@50": results_flare["r50"] / n,
                "Tanimoto@1_mean": sum(results_flare["tan"]) / len(results_flare["tan"]) if results_flare["tan"] else None,
            }

    if args.with_flare_spec:
        if index_flare is None:
            print("index_flare.faiss not found; skipping flare_spec_query.")
        elif not args.spec_tsv or not args.subformula_dir:
            print("Need --spec-tsv and --subformula-dir for --with-flare-spec; skipping.")
        else:
            print("Encoding spectra with FLARE spec encoder...")
            flare_spec = FLARESpecEmbedder(
                flare_repo=args.flare_repo,
                hparams_pth=args.flare_hparams,
                checkpoint_pth=args.flare_checkpoint,
                dataset_pth=args.spec_tsv,
                subformula_dir_pth=args.subformula_dir,
                fold=args.spec_fold,
                device=device,
                batch_size=args.batch_size,
                normalize=True,
            )
            q_spec, gt_smiles, ids = flare_spec.encode()
            if q_spec.shape[0] == 0:
                print("No spectra encoded for flare_spec_query.")
            else:
                scores_spec, indices_spec = index_search(index_flare, q_spec.astype(np.float32), K)
                m = q_spec.shape[0]
                results_spec = {"n": m, "r1": 0, "r10": 0, "r50": 0, "tan": []}
                for i in range(m):
                    idx_list = indices_spec[i].tolist()
                    gt = gt_smiles[i]
                    if recall_at_k(idx_list, meta_df, gt, 1):
                        results_spec["r1"] += 1
                    if recall_at_k(idx_list, meta_df, gt, 10):
                        results_spec["r10"] += 1
                    if recall_at_k(idx_list, meta_df, gt, 50):
                        results_spec["r50"] += 1
                    if idx_list and idx_list[0] < len(meta_df):
                        top_smi = meta_df.iloc[idx_list[0]]["smiles"]
                        t = tanimoto_at_1(top_smi, gt)
                        if t is not None:
                            results_spec["tan"].append(t)
                metrics["flare_spec_query"] = {
                    "n": results_spec["n"],
                    "fold": args.spec_fold,
                    "Recall@1": results_spec["r1"] / results_spec["n"],
                    "Recall@10": results_spec["r10"] / results_spec["n"],
                    "Recall@50": results_spec["r50"] / results_spec["n"],
                    "Tanimoto@1_mean": sum(results_spec["tan"]) / len(results_spec["tan"]) if results_spec["tan"] else None,
                }

    print("Oracle retrieval metrics:", json.dumps(metrics, indent=2))
    if args.report:
        with open(args.report, "w") as f:
            json.dump(metrics, f, indent=2)
        print(f"Wrote {args.report}")


if __name__ == "__main__":
    main()