Add raw_counts_data
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raw_counts_data/MasterFile.parquet
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raw_counts_data/counts.h5ad
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raw_counts_data/data_shape_summary.md
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| 1 |
+
# Z-Screen Dataset: Global Data Map & Architecture Summary
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| 2 |
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| 3 |
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This report maps the structural dimensions, screening configurations, cell lines, libraries, and device associations for the current dataset.
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| 4 |
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|
| 5 |
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> [!NOTE]
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| 6 |
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> This dataset contains transcriptomic counts representing **768,162 nanowells** profiled across **49 devices** (0–48), testing **14 libraries** against **6 cell lines / clone variants**.
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| 7 |
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>
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| 8 |
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> **Nanowell Architecture:** Each row/observation in the data represents a single **nanowell** rather than an individual cell. Each physical nanowell is **90 microns in diameter by 120 microns tall** and holds approximately **2–10 cells**.
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| 9 |
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|
| 10 |
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---
|
| 11 |
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|
| 12 |
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## 📊 High-Level Metrics
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|
| 14 |
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| Metric | Count | Details |
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| 15 |
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| :--- | :--- | :--- |
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| 16 |
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| **Total Wells (Observations)** | **768,162** | Mapped 1-to-1 across `MasterFile`, `chemistry`, and `counts.h5ad` |
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| 17 |
+
| **Total Features (Genes)** | **46,944** | Gene expression profiles stored in `counts.h5ad` |
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| 18 |
+
| **Screening Devices** | **49** | Numbered 0 to 48 |
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| 19 |
+
| **Unique Cell Lines** | **6** | HEK293, HEK293-clone, A549, H1650, THP1, AEC7 |
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| 20 |
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| **Screened Libraries** | **14** | 9 Named control compounds/control libraries, 3 OBOC libraries, 2 Control bead libraries |
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| 21 |
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| **Unique Compounds / Precursors** | **142,227** | 78 named controls, 142,149 OBOC building blocks, and controls |
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| 22 |
+
|
| 23 |
+
---
|
| 24 |
+
|
| 25 |
+
## 🧪 Libraries & Nomenclature Breakdown
|
| 26 |
+
|
| 27 |
+
The screening libraries and control sets are classified using the following nomenclature:
|
| 28 |
+
* **`ZEL` Prefix**: Represents **One-Bead One-Compound (OBOC) combinatorial libraries** (testing building block precursor fragments, e.g., `ZEL024`, `ZEL028-2`, `ZEL031`).
|
| 29 |
+
* **`ZIC` Prefix**: Represents **named control compounds** (testing targeted, fully synthesized compounds, e.g., target inhibition screen `ZIC008`).
|
| 30 |
+
* **No-Compound Controls**:
|
| 31 |
+
* **`ZEL026-2`** represents a **set of no-compound control beads** (not a combinatorial library).
|
| 32 |
+
* **`ZIC005`** & **`ZIC005-2`** represent **no-compound controls** (with `ZIC005` profiling water/vehicle controls).
|
| 33 |
+
|
| 34 |
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| Library | Nomenclature Category | Unique Compound IDs | Unique SMILES | Unique Names | Nanowell Count |
|
| 35 |
+
| :--- | :--- | :---: | :---: | :---: | :---: |
|
| 36 |
+
| **ZIC008** | Named Control Compounds | 35 | 35 | 35 | 256,052 |
|
| 37 |
+
| **ZEL024** | OBOC Combinatorial Library | 13,934 | 13,934 | 1 | 175,285 |
|
| 38 |
+
| **ZEL028-2** | OBOC Combinatorial Library | 117,950 | 117,950 | 1 | 134,821 |
|
| 39 |
+
| **ZEL026-2** | No-Compound Control Beads | 0 | 0 | 1 | 95,583 |
|
| 40 |
+
| **ZEL031** | OBOC Combinatorial Library | 10,265 | 10,265 | 1 | 43,241 |
|
| 41 |
+
| **ZIC009** | Named Control Compounds | 31 | 31 | 31 | 31,107 |
|
| 42 |
+
| **ZIC002** | Named Control Compounds | 7 | 0 | 7 | 10,999 |
|
| 43 |
+
| **ZIC005-2** | No-Compound Control | 0 | 0 | 1 | 7,891 |
|
| 44 |
+
| **ZIC001** | Named Control Compounds | 2 | 2 | 2 | 6,569 |
|
| 45 |
+
| **ZIC006** | Named Control Compounds | 1 | 1 | 1 | 2,099 |
|
| 46 |
+
| **ZIC004** | Named Control Compounds | 1 | 1 | 1 | 1,913 |
|
| 47 |
+
| **ZIC003** | Named Control Compounds | 2 | 0 | 2 | 1,880 |
|
| 48 |
+
| **ZIC007** | Named Control Compounds | 4 | 4 | 4 | 565 |
|
| 49 |
+
| **ZIC005** | No-Compound Control (Water) | 1 | 1 | 1 | 157 |
|
| 50 |
+
| **Total** | | **142,227** | **142,218** | **79** | **768,162** |
|
| 51 |
+
|
| 52 |
+
---
|
| 53 |
+
|
| 54 |
+
## 🧫 Cell Line Screen Matrix
|
| 55 |
+
|
| 56 |
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The table below shows the nanowell count distribution for each library screened across each cell line:
|
| 57 |
+
|
| 58 |
+
| Library | A549 | AEC7 | H1650 | HEK293 | HEK293-clone | THP1 | Total Wells |
|
| 59 |
+
| :--- | :---: | :---: | :---: | :---: | :---: | :---: | :---: |
|
| 60 |
+
| **ZEL024** | 0 | 0 | 21,545 | 153,740 | 0 | 0 | 175,285 |
|
| 61 |
+
| **ZEL026-2** | 26,718 | 36,827 | 17,086 | 0 | 14,952 | 0 | 95,583 |
|
| 62 |
+
| **ZEL028-2** | 42,435 | 0 | 26,694 | 65,692 | 0 | 0 | 134,821 |
|
| 63 |
+
| **ZEL031** | 20,868 | 0 | 431 | 0 | 0 | 21,942 | 43,241 |
|
| 64 |
+
| **ZIC001** | 0 | 0 | 1,229 | 3,858 | 0 | 1,482 | 6,569 |
|
| 65 |
+
| **ZIC002** | 0 | 0 | 806 | 9,558 | 0 | 635 | 10,999 |
|
| 66 |
+
| **ZIC003** | 0 | 0 | 378 | 919 | 0 | 583 | 1,880 |
|
| 67 |
+
| **ZIC004** | 122 | 0 | 411 | 0 | 0 | 1,380 | 1,913 |
|
| 68 |
+
| **ZIC005** | 0 | 0 | 109 | 0 | 0 | 48 | 157 |
|
| 69 |
+
| **ZIC005-2** | 0 | 7,891 | 0 | 0 | 0 | 0 | 7,891 |
|
| 70 |
+
| **ZIC006** | 207 | 0 | 631 | 0 | 0 | 1,261 | 2,099 |
|
| 71 |
+
| **ZIC007** | 0 | 0 | 452 | 0 | 0 | 113 | 565 |
|
| 72 |
+
| **ZIC008** | 84,952 | 91,448 | 26,382 | 19,010 | 34,260 | 0 | 256,052 |
|
| 73 |
+
| **ZIC009** | 0 | 31,107 | 0 | 0 | 0 | 0 | 31,107 |
|
| 74 |
+
|
| 75 |
+
---
|
| 76 |
+
|
| 77 |
+
## 📱 Devices Analysis & Metadata Mapping
|
| 78 |
+
|
| 79 |
+
### 1. Is each device an individual cell line?
|
| 80 |
+
**Yes.** Every physical screening device (0–48) runs exactly **one cell line** (no cell line mixing on-chip).
|
| 81 |
+
|
| 82 |
+
### 2. Is each device a unique library?
|
| 83 |
+
**No.** Every device contains **multiple libraries** (ranging from **2 to 8** libraries pooled per device).
|
| 84 |
+
|
| 85 |
+
### 3. How many devices contain no-compound controls?
|
| 86 |
+
* **No-Compound Controls**: Present in **24 devices** (Devices 8, 9, 17, 18, 21, 22, 29, 30, and 33 through 48, representing `capture_only` roles and water vehicle control sets).
|
| 87 |
+
* **OBOC Combinatorial Libraries**: Present in **24 devices** (Devices 0–7, 10, 12–16, 19, 20, 23–28, 31, 32).
|
| 88 |
+
* **Only 1 Device (Device 11)** contains named control compounds exclusively with no-compound or combinatorial controls.
|
| 89 |
+
|
| 90 |
+
---
|
| 91 |
+
|
| 92 |
+
## 🗺️ Detailed Device Map
|
| 93 |
+
|
| 94 |
+
The device-by-device configuration shows cell line mapping and library counts:
|
| 95 |
+
|
| 96 |
+
| Device ID | Cell Line | Libraries Mapped | Wells Count | Control Roles |
|
| 97 |
+
| :---: | :--- | :--- | :---: | :--- |
|
| 98 |
+
| **Device 0** | HEK293 | `ZEL024, ZIC002, ZIC001` | 27,361 | OBOC Library (25,310), Named Controls (2,051) |
|
| 99 |
+
| **Device 1** | HEK293 | `ZEL024, ZIC002, ZIC001` | 22,011 | OBOC Library (20,398), Named Controls (1,613) |
|
| 100 |
+
| **Device 2** | HEK293 | `ZEL024, ZIC002, ZIC001` | 32,906 | OBOC Library (30,307), Named Controls (2,599) |
|
| 101 |
+
| **Device 3** | HEK293 | `ZEL024, ZIC002, ZIC001` | 30,518 | OBOC Library (28,064), Named Controls (2,454) |
|
| 102 |
+
| **Device 4** | HEK293 | `ZEL024, ZIC003, ZIC002, ZIC001` | 30,013 | OBOC Library (26,973), Named Controls (3,040) |
|
| 103 |
+
| **Device 5** | HEK293 | `ZEL024, ZIC003, ZIC002, ZIC001` | 25,266 | OBOC Library (22,688), Named Controls (2,578) |
|
| 104 |
+
| **Device 6** | H1650 | `ZEL024, ZIC002, ZIC005, ZIC001, ZIC003` | 20,099 | OBOC Library (19,253), Named Controls (846 - including ZIC005 Water Control) |
|
| 105 |
+
| **Device 7** | H1650 | `ZEL024, ZIC003, ZIC005, ZIC002, ZIC001` | 2,555 | OBOC Library (2,292), Named Controls (263 - including ZIC005 Water Control) |
|
| 106 |
+
| **Device 8** | H1650 | `ZEL026-2, ZIC007, ZIC004, ZIC006, ZIC003, ZIC002, ZIC001` | 12,422 | No-Compound Control Beads (10,369), Named Controls (2,053) |
|
| 107 |
+
| **Device 9** | H1650 | `ZEL026-2, ZIC006, ZIC003, ZIC004, ZIC002, ZIC001, ZIC007` | 7,571 | No-Compound Control Beads (6,717), Named Controls (854) |
|
| 108 |
+
| **Device 10** | THP1 | `ZIC006, ZEL031, ZIC007, ZIC004, ZIC005, ZIC002, ZIC003, ZIC001` | 3,748 | OBOC Library (2,837), Named Controls (911 - including ZIC005 Water Control) |
|
| 109 |
+
| **Device 11** | A549 | `ZIC006, ZIC004` | 257 | Named Controls (257) |
|
| 110 |
+
| **Device 12** | THP1 | `ZEL031, ZIC004, ZIC006, ZIC003, ZIC002, ZIC001` | 23,696 | OBOC Library (19,105), Named Controls (4,591) |
|
| 111 |
+
| **Device 13** | A549 | `ZIC008, ZEL031` | 13,602 | Named Controls (7,771), OBOC Library (5,831) |
|
| 112 |
+
| **Device 14** | A549 | `ZIC008, ZEL031` | 9,878 | Named Controls (5,583), OBOC Library (4,295) |
|
| 113 |
+
| **Device 15** | A549 | `ZIC008, ZEL031` | 16,898 | Named Controls (11,376), OBOC Library (5,522) |
|
| 114 |
+
| **Device 16** | A549 | `ZIC008, ZEL031` | 12,261 | Named Controls (7,041), OBOC Library (5,220) |
|
| 115 |
+
| **Device 17** | A549 | `ZIC008, ZEL026-2, ZIC004` | 13,675 | Named Controls (9,757), No-Compound Control Beads (3,918) |
|
| 116 |
+
| **Device 18** | A549 | `ZIC008, ZEL026-2, ZIC004` | 11,332 | Named Controls (8,428), No-Compound Control Beads (2,904) |
|
| 117 |
+
| **Device 19** | H1650 | `ZIC008, ZEL031` | 6,390 | Named Controls (6,283), OBOC Library (107) |
|
| 118 |
+
| **Device 20** | H1650 | `ZIC008, ZEL031` | 14,227 | Named Controls (13,903), OBOC Library (324) |
|
| 119 |
+
| **Device 21** | A549 | `ZEL026-2, ZIC008` | 27,839 | Named Controls (15,125), No-Compound Control Beads (12,714) |
|
| 120 |
+
| **Device 22** | A549 | `ZIC008, ZEL026-2` | 18,240 | Named Controls (11,058), No-Compound Control Beads (7,182) |
|
| 121 |
+
| **Device 23** | A549 | `ZIC008, ZEL028-2` | 23,608 | OBOC Library (20,152), Named Controls (3,456) |
|
| 122 |
+
| **Device 24** | H1650 | `ZIC008, ZEL028-2` | 14,178 | OBOC Library (12,056), Named Controls (2,122) |
|
| 123 |
+
| **Device 25** | A549 | `ZIC008, ZEL028-2` | 27,712 | OBOC Library (22,283), Named Controls (5,429) |
|
| 124 |
+
| **Device 26** | H1650 | `ZIC008, ZEL028-2` | 18,712 | OBOC Library (14,638), Named Controls (4,074) |
|
| 125 |
+
| **Device 27** | HEK293 | `ZIC008, ZEL028-2` | 17,999 | OBOC Library (14,494), Named Controls (3,505) |
|
| 126 |
+
| **Device 28** | HEK293 | `ZIC008, ZEL028-2` | 15,808 | OBOC Library (12,865), Named Controls (2,943) |
|
| 127 |
+
| **Device 29** | HEK293-clone | `ZIC008, ZEL026-2` | 27,829 | Named Controls (19,951), No-Compound Control Beads (7,878) |
|
| 128 |
+
| **Device 30** | HEK293-clone | `ZIC008, ZEL026-2` | 21,383 | Named Controls (14,309), No-Compound Control Beads (7,074) |
|
| 129 |
+
| **Device 31** | HEK293 | `ZIC008, ZEL028-2` | 27,521 | OBOC Library (20,770), Named Controls (6,751) |
|
| 130 |
+
| **Device 32** | HEK293 | `ZIC008, ZEL028-2` | 23,374 | OBOC Library (17,563), Named Controls (5,811) |
|
| 131 |
+
| **Device 33** | AEC7 | `ZIC008, ZEL026-2, ZIC009` | 11,498 | Named Controls (7,910), No-Compound Control Beads (3,588) |
|
| 132 |
+
| **Device 34** | AEC7 | `ZEL026-2, ZIC008, ZIC009` | 11,250 | Named Controls (7,340), No-Compound Control Beads (3,910) |
|
| 133 |
+
| **Device 35** | AEC7 | `ZIC008, ZEL026-2, ZIC009` | 9,165 | Named Controls (6,075), No-Compound Control Beads (3,090) |
|
| 134 |
+
| **Device 36** | AEC7 | `ZIC008, ZEL026-2, ZIC009` | 12,111 | Named Controls (8,004), No-Compound Control Beads (4,107) |
|
| 135 |
+
| **Device 37** | AEC7 | `ZIC008, ZEL026-2, ZIC009` | 13,390 | Named Controls (9,358), No-Compound Control Beads (4,032) |
|
| 136 |
+
| **Device 38** | AEC7 | `ZEL026-2, ZIC008, ZIC009` | 17,504 | Named Controls (12,360), No-Compound Control Beads (5,144) |
|
| 137 |
+
| **Device 39** | AEC7 | `ZIC008, ZEL026-2, ZIC009` | 21,192 | Named Controls (13,801), No-Compound Control Beads (7,391) |
|
| 138 |
+
| **Device 40** | AEC7 | `ZIC008, ZEL026-2, ZIC009` | 16,318 | Named Controls (10,753), No-Compound Control Beads (5,565) |
|
| 139 |
+
| **Device 41** | AEC7 | `ZIC008, ZIC005-2, ZIC009` | 2,929 | Named Controls (2,587), No-Compound Control (342) |
|
| 140 |
+
| **Device 42** | AEC7 | `ZIC008, ZIC009, ZIC005-2` | 4,660 | Named Controls (3,990), No-Compound Control (670) |
|
| 141 |
+
| **Device 43** | AEC7 | `ZIC008, ZIC005-2, ZIC009` | 11,537 | Named Controls (9,698), No-Compound Control (1,839) |
|
| 142 |
+
| **Device 44** | AEC7 | `ZIC008, ZIC005-2, ZIC009` | 10,472 | Named Controls (8,618), No-Compound Control (1,854) |
|
| 143 |
+
| **Device 45** | AEC7 | `ZIC008, ZIC005-2, ZIC009` | 7,223 | Named Controls (6,209), No-Compound Control (1,014) |
|
| 144 |
+
| **Device 46** | AEC7 | `ZIC008, ZIC005-2, ZIC009` | 8,258 | Named Controls (7,242), No-Compound Control (1,016) |
|
| 145 |
+
| **Device 47** | AEC7 | `ZIC008, ZIC009, ZIC005-2` | 5,983 | Named Controls (5,136), No-Compound Control (847) |
|
| 146 |
+
| **Device 48** | AEC7 | `ZIC008, ZIC005-2, ZIC009` | 3,783 | Named Controls (3,474), No-Compound Control (309) |
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|
| 1 |
+
<!DOCTYPE html>
|
| 2 |
+
<html lang="en">
|
| 3 |
+
<head>
|
| 4 |
+
<meta charset="UTF-8">
|
| 5 |
+
<title>Z-Screen Data Shape Explorer</title>
|
| 6 |
+
<link href="https://fonts.googleapis.com/css2?family=Outfit:wght@300;400;500;600;700&family=JetBrains+Mono:wght@400;500&display=swap" rel="stylesheet">
|
| 7 |
+
<script src="https://cdn.jsdelivr.net/npm/chart.js"></script>
|
| 8 |
+
<style>
|
| 9 |
+
:root {
|
| 10 |
+
--bg-color: #0b0f19;
|
| 11 |
+
--card-bg: rgba(17, 25, 40, 0.75);
|
| 12 |
+
--border-color: rgba(255, 255, 255, 0.08);
|
| 13 |
+
--text-color: #f3f4f6;
|
| 14 |
+
--text-muted: #9ca3af;
|
| 15 |
+
--primary: #8b5cf6;
|
| 16 |
+
--primary-glow: rgba(139, 92, 246, 0.4);
|
| 17 |
+
--secondary: #06b6d4;
|
| 18 |
+
--accent: #f43f5e;
|
| 19 |
+
--font-main: 'Outfit', sans-serif;
|
| 20 |
+
--font-mono: 'JetBrains Mono', monospace;
|
| 21 |
+
}
|
| 22 |
+
|
| 23 |
+
* {
|
| 24 |
+
box-sizing: border-box;
|
| 25 |
+
margin: 0;
|
| 26 |
+
padding: 0;
|
| 27 |
+
}
|
| 28 |
+
|
| 29 |
+
body {
|
| 30 |
+
background-color: var(--bg-color);
|
| 31 |
+
color: var(--text-color);
|
| 32 |
+
font-family: var(--font-main);
|
| 33 |
+
min-height: 100vh;
|
| 34 |
+
overflow-x: hidden;
|
| 35 |
+
background-image:
|
| 36 |
+
radial-gradient(at 0% 0%, rgba(99, 102, 241, 0.1) 0, transparent 50%),
|
| 37 |
+
radial-gradient(at 50% 0%, rgba(139, 92, 246, 0.08) 0, transparent 50%),
|
| 38 |
+
radial-gradient(at 100% 100%, rgba(6, 182, 212, 0.08) 0, transparent 50%);
|
| 39 |
+
background-attachment: fixed;
|
| 40 |
+
}
|
| 41 |
+
|
| 42 |
+
header {
|
| 43 |
+
padding: 2.5rem 4rem 1.5rem 4rem;
|
| 44 |
+
border-bottom: 1px solid var(--border-color);
|
| 45 |
+
background: rgba(11, 15, 25, 0.8);
|
| 46 |
+
backdrop-filter: blur(12px);
|
| 47 |
+
position: sticky;
|
| 48 |
+
top: 0;
|
| 49 |
+
z-index: 100;
|
| 50 |
+
display: flex;
|
| 51 |
+
justify-content: space-between;
|
| 52 |
+
align-items: center;
|
| 53 |
+
}
|
| 54 |
+
|
| 55 |
+
.header-title h1 {
|
| 56 |
+
font-size: 1.8rem;
|
| 57 |
+
font-weight: 700;
|
| 58 |
+
background: linear-gradient(135deg, #fff 30%, var(--primary) 70%, var(--secondary) 100%);
|
| 59 |
+
-webkit-background-clip: text;
|
| 60 |
+
-webkit-text-fill-color: transparent;
|
| 61 |
+
margin-bottom: 0.25rem;
|
| 62 |
+
}
|
| 63 |
+
|
| 64 |
+
.header-title p {
|
| 65 |
+
color: var(--text-muted);
|
| 66 |
+
font-size: 0.95rem;
|
| 67 |
+
}
|
| 68 |
+
|
| 69 |
+
.nav-tabs {
|
| 70 |
+
display: flex;
|
| 71 |
+
gap: 0.5rem;
|
| 72 |
+
background: rgba(255, 255, 255, 0.03);
|
| 73 |
+
padding: 0.35rem;
|
| 74 |
+
border-radius: 30px;
|
| 75 |
+
border: 1px solid var(--border-color);
|
| 76 |
+
}
|
| 77 |
+
|
| 78 |
+
.tab-btn {
|
| 79 |
+
background: transparent;
|
| 80 |
+
border: none;
|
| 81 |
+
color: var(--text-muted);
|
| 82 |
+
padding: 0.6rem 1.4rem;
|
| 83 |
+
font-size: 0.9rem;
|
| 84 |
+
font-weight: 500;
|
| 85 |
+
border-radius: 25px;
|
| 86 |
+
cursor: pointer;
|
| 87 |
+
transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
|
| 88 |
+
}
|
| 89 |
+
|
| 90 |
+
.tab-btn.active {
|
| 91 |
+
background: var(--primary);
|
| 92 |
+
color: #fff;
|
| 93 |
+
box-shadow: 0 0 15px var(--primary-glow);
|
| 94 |
+
}
|
| 95 |
+
|
| 96 |
+
.tab-btn:hover:not(.active) {
|
| 97 |
+
color: #fff;
|
| 98 |
+
background: rgba(255, 255, 255, 0.05);
|
| 99 |
+
}
|
| 100 |
+
|
| 101 |
+
.container {
|
| 102 |
+
max-width: 1400px;
|
| 103 |
+
margin: 2rem auto;
|
| 104 |
+
padding: 0 2rem;
|
| 105 |
+
}
|
| 106 |
+
|
| 107 |
+
.tab-content {
|
| 108 |
+
display: none;
|
| 109 |
+
}
|
| 110 |
+
|
| 111 |
+
.tab-content.active {
|
| 112 |
+
display: block;
|
| 113 |
+
animation: fadeIn 0.4s ease-out;
|
| 114 |
+
}
|
| 115 |
+
|
| 116 |
+
@keyframes fadeIn {
|
| 117 |
+
from { opacity: 0; transform: translateY(10px); }
|
| 118 |
+
to { opacity: 1; transform: translateY(0); }
|
| 119 |
+
}
|
| 120 |
+
|
| 121 |
+
/* Dashboard Overview Grid */
|
| 122 |
+
.stats-grid {
|
| 123 |
+
display: grid;
|
| 124 |
+
grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
|
| 125 |
+
gap: 1.5rem;
|
| 126 |
+
margin-bottom: 2rem;
|
| 127 |
+
}
|
| 128 |
+
|
| 129 |
+
.stat-card {
|
| 130 |
+
background: var(--card-bg);
|
| 131 |
+
border: 1px solid var(--border-color);
|
| 132 |
+
border-radius: 16px;
|
| 133 |
+
padding: 1.5rem;
|
| 134 |
+
backdrop-filter: blur(16px);
|
| 135 |
+
position: relative;
|
| 136 |
+
overflow: hidden;
|
| 137 |
+
transition: border-color 0.3s;
|
| 138 |
+
}
|
| 139 |
+
|
| 140 |
+
.stat-card:hover {
|
| 141 |
+
border-color: rgba(139, 92, 246, 0.3);
|
| 142 |
+
}
|
| 143 |
+
|
| 144 |
+
.stat-card::before {
|
| 145 |
+
content: '';
|
| 146 |
+
position: absolute;
|
| 147 |
+
top: 0;
|
| 148 |
+
left: 0;
|
| 149 |
+
width: 4px;
|
| 150 |
+
height: 100%;
|
| 151 |
+
background: var(--primary);
|
| 152 |
+
}
|
| 153 |
+
|
| 154 |
+
.stat-card.cyan::before { background: var(--secondary); }
|
| 155 |
+
.stat-card.accent::before { background: var(--accent); }
|
| 156 |
+
|
| 157 |
+
.stat-label {
|
| 158 |
+
color: var(--text-muted);
|
| 159 |
+
font-size: 0.85rem;
|
| 160 |
+
text-transform: uppercase;
|
| 161 |
+
letter-spacing: 0.05em;
|
| 162 |
+
margin-bottom: 0.5rem;
|
| 163 |
+
}
|
| 164 |
+
|
| 165 |
+
.stat-value {
|
| 166 |
+
font-size: 2.2rem;
|
| 167 |
+
font-weight: 700;
|
| 168 |
+
margin-bottom: 0.25rem;
|
| 169 |
+
font-family: var(--font-mono);
|
| 170 |
+
}
|
| 171 |
+
|
| 172 |
+
.stat-subtext {
|
| 173 |
+
color: var(--text-muted);
|
| 174 |
+
font-size: 0.85rem;
|
| 175 |
+
}
|
| 176 |
+
|
| 177 |
+
.grid-2col {
|
| 178 |
+
display: grid;
|
| 179 |
+
grid-template-columns: 1fr 1fr;
|
| 180 |
+
gap: 2rem;
|
| 181 |
+
margin-bottom: 2rem;
|
| 182 |
+
}
|
| 183 |
+
|
| 184 |
+
@media (max-width: 900px) {
|
| 185 |
+
.grid-2col {
|
| 186 |
+
grid-template-columns: 1fr;
|
| 187 |
+
}
|
| 188 |
+
}
|
| 189 |
+
|
| 190 |
+
.panel {
|
| 191 |
+
background: var(--card-bg);
|
| 192 |
+
border: 1px solid var(--border-color);
|
| 193 |
+
border-radius: 20px;
|
| 194 |
+
padding: 2rem;
|
| 195 |
+
backdrop-filter: blur(16px);
|
| 196 |
+
}
|
| 197 |
+
|
| 198 |
+
.panel-title {
|
| 199 |
+
font-size: 1.25rem;
|
| 200 |
+
font-weight: 600;
|
| 201 |
+
margin-bottom: 1.5rem;
|
| 202 |
+
display: flex;
|
| 203 |
+
align-items: center;
|
| 204 |
+
justify-content: space-between;
|
| 205 |
+
}
|
| 206 |
+
|
| 207 |
+
.panel-subtitle {
|
| 208 |
+
color: var(--text-muted);
|
| 209 |
+
font-size: 0.9rem;
|
| 210 |
+
font-weight: 400;
|
| 211 |
+
}
|
| 212 |
+
|
| 213 |
+
/* Heatmap styling */
|
| 214 |
+
.heatmap-container {
|
| 215 |
+
display: flex;
|
| 216 |
+
flex-direction: column;
|
| 217 |
+
overflow-x: auto;
|
| 218 |
+
}
|
| 219 |
+
|
| 220 |
+
.heatmap-grid {
|
| 221 |
+
display: grid;
|
| 222 |
+
grid-template-columns: 120px repeat(6, 1fr);
|
| 223 |
+
gap: 6px;
|
| 224 |
+
margin-top: 1rem;
|
| 225 |
+
min-width: 700px;
|
| 226 |
+
}
|
| 227 |
+
|
| 228 |
+
.heatmap-header-cell {
|
| 229 |
+
font-size: 0.9rem;
|
| 230 |
+
font-weight: 600;
|
| 231 |
+
text-align: center;
|
| 232 |
+
padding: 0.75rem 0.5rem;
|
| 233 |
+
color: var(--text-muted);
|
| 234 |
+
}
|
| 235 |
+
|
| 236 |
+
.heatmap-label-cell {
|
| 237 |
+
font-size: 0.85rem;
|
| 238 |
+
font-weight: 500;
|
| 239 |
+
display: flex;
|
| 240 |
+
align-items: center;
|
| 241 |
+
justify-content: flex-end;
|
| 242 |
+
padding-right: 1rem;
|
| 243 |
+
font-family: var(--font-mono);
|
| 244 |
+
}
|
| 245 |
+
|
| 246 |
+
.heatmap-cell {
|
| 247 |
+
border-radius: 6px;
|
| 248 |
+
padding: 1.2rem 0.5rem;
|
| 249 |
+
text-align: center;
|
| 250 |
+
font-size: 0.85rem;
|
| 251 |
+
font-weight: 600;
|
| 252 |
+
cursor: pointer;
|
| 253 |
+
transition: transform 0.2s, box-shadow 0.2s;
|
| 254 |
+
display: flex;
|
| 255 |
+
flex-direction: column;
|
| 256 |
+
justify-content: center;
|
| 257 |
+
align-items: center;
|
| 258 |
+
}
|
| 259 |
+
|
| 260 |
+
.heatmap-cell:hover {
|
| 261 |
+
transform: scale(1.05);
|
| 262 |
+
z-index: 10;
|
| 263 |
+
box-shadow: 0 0 12px rgba(255, 255, 255, 0.15);
|
| 264 |
+
}
|
| 265 |
+
|
| 266 |
+
.heatmap-cell-value {
|
| 267 |
+
font-family: var(--font-mono);
|
| 268 |
+
font-size: 0.85rem;
|
| 269 |
+
}
|
| 270 |
+
|
| 271 |
+
.heatmap-cell-pct {
|
| 272 |
+
font-size: 0.7rem;
|
| 273 |
+
font-weight: 400;
|
| 274 |
+
opacity: 0.8;
|
| 275 |
+
margin-top: 2px;
|
| 276 |
+
}
|
| 277 |
+
|
| 278 |
+
.heatmap-legend {
|
| 279 |
+
display: flex;
|
| 280 |
+
gap: 1.5rem;
|
| 281 |
+
margin-top: 2rem;
|
| 282 |
+
justify-content: center;
|
| 283 |
+
font-size: 0.85rem;
|
| 284 |
+
color: var(--text-muted);
|
| 285 |
+
}
|
| 286 |
+
|
| 287 |
+
.legend-item {
|
| 288 |
+
display: flex;
|
| 289 |
+
align-items: center;
|
| 290 |
+
gap: 0.5rem;
|
| 291 |
+
}
|
| 292 |
+
|
| 293 |
+
.legend-color {
|
| 294 |
+
width: 16px;
|
| 295 |
+
height: 16px;
|
| 296 |
+
border-radius: 4px;
|
| 297 |
+
}
|
| 298 |
+
|
| 299 |
+
/* Device Table */
|
| 300 |
+
.search-box {
|
| 301 |
+
display: flex;
|
| 302 |
+
gap: 1rem;
|
| 303 |
+
margin-bottom: 1.5rem;
|
| 304 |
+
}
|
| 305 |
+
|
| 306 |
+
.search-input {
|
| 307 |
+
flex: 1;
|
| 308 |
+
background: rgba(255, 255, 255, 0.05);
|
| 309 |
+
border: 1px solid var(--border-color);
|
| 310 |
+
border-radius: 30px;
|
| 311 |
+
padding: 0.75rem 1.5rem;
|
| 312 |
+
color: #fff;
|
| 313 |
+
font-family: var(--font-main);
|
| 314 |
+
font-size: 0.95rem;
|
| 315 |
+
outline: none;
|
| 316 |
+
transition: border-color 0.3s;
|
| 317 |
+
}
|
| 318 |
+
|
| 319 |
+
.search-input:focus {
|
| 320 |
+
border-color: var(--primary);
|
| 321 |
+
}
|
| 322 |
+
|
| 323 |
+
.filter-select {
|
| 324 |
+
background: rgba(255, 255, 255, 0.05);
|
| 325 |
+
border: 1px solid var(--border-color);
|
| 326 |
+
border-radius: 30px;
|
| 327 |
+
padding: 0.75rem 1.5rem;
|
| 328 |
+
color: #fff;
|
| 329 |
+
font-family: var(--font-main);
|
| 330 |
+
outline: none;
|
| 331 |
+
cursor: pointer;
|
| 332 |
+
}
|
| 333 |
+
|
| 334 |
+
.table-wrapper {
|
| 335 |
+
overflow-x: auto;
|
| 336 |
+
border-radius: 12px;
|
| 337 |
+
border: 1px solid var(--border-color);
|
| 338 |
+
}
|
| 339 |
+
|
| 340 |
+
table {
|
| 341 |
+
width: 100%;
|
| 342 |
+
border-collapse: collapse;
|
| 343 |
+
text-align: left;
|
| 344 |
+
font-size: 0.9rem;
|
| 345 |
+
}
|
| 346 |
+
|
| 347 |
+
th {
|
| 348 |
+
background: rgba(255, 255, 255, 0.02);
|
| 349 |
+
font-weight: 600;
|
| 350 |
+
color: var(--text-muted);
|
| 351 |
+
padding: 1rem;
|
| 352 |
+
border-bottom: 1px solid var(--border-color);
|
| 353 |
+
text-transform: uppercase;
|
| 354 |
+
font-size: 0.8rem;
|
| 355 |
+
letter-spacing: 0.05em;
|
| 356 |
+
}
|
| 357 |
+
|
| 358 |
+
td {
|
| 359 |
+
padding: 1rem;
|
| 360 |
+
border-bottom: 1px solid var(--border-color);
|
| 361 |
+
vertical-align: middle;
|
| 362 |
+
}
|
| 363 |
+
|
| 364 |
+
tr:last-child td {
|
| 365 |
+
border-bottom: none;
|
| 366 |
+
}
|
| 367 |
+
|
| 368 |
+
tr:hover td {
|
| 369 |
+
background: rgba(255, 255, 255, 0.01);
|
| 370 |
+
}
|
| 371 |
+
|
| 372 |
+
.badge {
|
| 373 |
+
display: inline-block;
|
| 374 |
+
padding: 0.3rem 0.6rem;
|
| 375 |
+
border-radius: 20px;
|
| 376 |
+
font-size: 0.75rem;
|
| 377 |
+
font-weight: 600;
|
| 378 |
+
text-transform: uppercase;
|
| 379 |
+
}
|
| 380 |
+
|
| 381 |
+
.badge-purple { background: rgba(139, 92, 246, 0.15); color: #a78bfa; border: 1px solid rgba(139, 92, 246, 0.3); }
|
| 382 |
+
.badge-cyan { background: rgba(6, 182, 212, 0.15); color: #22d3ee; border: 1px solid rgba(6, 182, 212, 0.3); }
|
| 383 |
+
.badge-rose { background: rgba(244, 63, 94, 0.15); color: #fb7185; border: 1px solid rgba(244, 63, 94, 0.3); }
|
| 384 |
+
.badge-orange { background: rgba(249, 115, 22, 0.15); color: #fdba74; border: 1px solid rgba(249, 115, 22, 0.3); }
|
| 385 |
+
.badge-blue { background: rgba(59, 130, 246, 0.15); color: #60a5fa; border: 1px solid rgba(59, 130, 246, 0.3); }
|
| 386 |
+
|
| 387 |
+
/* Library details grid */
|
| 388 |
+
.lib-grid {
|
| 389 |
+
display: grid;
|
| 390 |
+
grid-template-columns: repeat(auto-fill, minmax(320px, 1fr));
|
| 391 |
+
gap: 1.5rem;
|
| 392 |
+
}
|
| 393 |
+
|
| 394 |
+
.lib-card {
|
| 395 |
+
background: var(--card-bg);
|
| 396 |
+
border: 1px solid var(--border-color);
|
| 397 |
+
border-radius: 16px;
|
| 398 |
+
padding: 1.5rem;
|
| 399 |
+
backdrop-filter: blur(12px);
|
| 400 |
+
display: flex;
|
| 401 |
+
flex-direction: column;
|
| 402 |
+
justify-content: space-between;
|
| 403 |
+
}
|
| 404 |
+
|
| 405 |
+
.lib-name {
|
| 406 |
+
font-size: 1.2rem;
|
| 407 |
+
font-weight: 600;
|
| 408 |
+
margin-bottom: 0.5rem;
|
| 409 |
+
font-family: var(--font-mono);
|
| 410 |
+
display: flex;
|
| 411 |
+
justify-content: space-between;
|
| 412 |
+
align-items: center;
|
| 413 |
+
}
|
| 414 |
+
|
| 415 |
+
.lib-details-row {
|
| 416 |
+
display: flex;
|
| 417 |
+
justify-content: space-between;
|
| 418 |
+
padding: 0.4rem 0;
|
| 419 |
+
border-bottom: 1px solid rgba(255, 255, 255, 0.04);
|
| 420 |
+
font-size: 0.9rem;
|
| 421 |
+
}
|
| 422 |
+
|
| 423 |
+
.lib-details-row:last-child {
|
| 424 |
+
border-bottom: none;
|
| 425 |
+
}
|
| 426 |
+
|
| 427 |
+
.lib-details-label {
|
| 428 |
+
color: var(--text-muted);
|
| 429 |
+
}
|
| 430 |
+
|
| 431 |
+
.lib-details-val {
|
| 432 |
+
font-family: var(--font-mono);
|
| 433 |
+
font-weight: 500;
|
| 434 |
+
}
|
| 435 |
+
|
| 436 |
+
.roles-list {
|
| 437 |
+
margin-top: 1rem;
|
| 438 |
+
display: flex;
|
| 439 |
+
flex-wrap: wrap;
|
| 440 |
+
gap: 0.5rem;
|
| 441 |
+
}
|
| 442 |
+
</style>
|
| 443 |
+
</head>
|
| 444 |
+
<body>
|
| 445 |
+
|
| 446 |
+
<header>
|
| 447 |
+
<div class="header-title">
|
| 448 |
+
<h1>Z-Screen Data Shape Explorer</h1>
|
| 449 |
+
<p>Interactive structural visualization of nanowells, devices, cell lines, and libraries</p>
|
| 450 |
+
</div>
|
| 451 |
+
<div class="nav-tabs">
|
| 452 |
+
<button class="tab-btn active" onclick="switchTab('tab-overview')">Overview</button>
|
| 453 |
+
<button class="tab-btn" onclick="switchTab('tab-matrix')">Screen Matrix</button>
|
| 454 |
+
<button class="tab-btn" onclick="switchTab('tab-devices')">Device Mapping</button>
|
| 455 |
+
<button class="tab-btn" onclick="switchTab('tab-libraries')">Libraries</button>
|
| 456 |
+
</div>
|
| 457 |
+
</header>
|
| 458 |
+
|
| 459 |
+
<div class="container">
|
| 460 |
+
|
| 461 |
+
<!-- OVERVIEW TAB -->
|
| 462 |
+
<div id="tab-overview" class="tab-content active">
|
| 463 |
+
<div class="stats-grid">
|
| 464 |
+
<div class="stat-card">
|
| 465 |
+
<div class="stat-label">Total Observations (Nanowells)</div>
|
| 466 |
+
<div class="stat-value">768,162</div>
|
| 467 |
+
<div class="stat-subtext">Mapped across 49 devices</div>
|
| 468 |
+
</div>
|
| 469 |
+
<div class="stat-card cyan">
|
| 470 |
+
<div class="stat-label">Total Features (Genes)</div>
|
| 471 |
+
<div class="stat-value">46,944</div>
|
| 472 |
+
<div class="stat-subtext">In counts.h5ad matrix</div>
|
| 473 |
+
</div>
|
| 474 |
+
<div class="stat-card">
|
| 475 |
+
<div class="stat-label">Screening Devices</div>
|
| 476 |
+
<div class="stat-value">49</div>
|
| 477 |
+
<div class="stat-subtext">Numbered 0 to 48</div>
|
| 478 |
+
</div>
|
| 479 |
+
<div class="stat-card accent">
|
| 480 |
+
<div class="stat-label">Unique Compounds</div>
|
| 481 |
+
<div class="stat-value">142,227</div>
|
| 482 |
+
<div class="stat-subtext">Including 142.1k building blocks</div>
|
| 483 |
+
</div>
|
| 484 |
+
</div>
|
| 485 |
+
|
| 486 |
+
<!-- Nanowell Info Alert Box -->
|
| 487 |
+
<div class="panel" style="margin-bottom: 2rem; border-left: 4px solid var(--secondary); background: rgba(6, 182, 212, 0.04);">
|
| 488 |
+
<h3 style="color: var(--secondary); font-size: 1.1rem; margin-bottom: 0.5rem; display: flex; align-items: center; gap: 0.5rem;">
|
| 489 |
+
🔬 Nanowell Architecture Specification
|
| 490 |
+
</h3>
|
| 491 |
+
<p style="color: var(--text-color); font-size: 0.95rem; line-height: 1.5;">
|
| 492 |
+
Each observation (row) in the dataset corresponds to a single **nanowell** rather than a single cell. Each nanowell measures **90 microns in diameter by 120 microns tall** and holds approximately **2 to 10 cells**. The transcriptomic profiles represent the pooled expression of the cells inside each nanowell.
|
| 493 |
+
</p>
|
| 494 |
+
</div>
|
| 495 |
+
|
| 496 |
+
<div class="grid-2col">
|
| 497 |
+
<div class="panel">
|
| 498 |
+
<div class="panel-title">
|
| 499 |
+
<span>Nanowells per Cell Line</span>
|
| 500 |
+
<span class="panel-subtitle">Total profiled nanowells</span>
|
| 501 |
+
</div>
|
| 502 |
+
<div style="height: 300px; position: relative;">
|
| 503 |
+
<canvas id="cellLineChart"></canvas>
|
| 504 |
+
</div>
|
| 505 |
+
</div>
|
| 506 |
+
<div class="panel">
|
| 507 |
+
<div class="panel-title">
|
| 508 |
+
<span>Dataset Role Split</span>
|
| 509 |
+
<span class="panel-subtitle">By screening category (wells)</span>
|
| 510 |
+
</div>
|
| 511 |
+
<div style="height: 300px; position: relative;">
|
| 512 |
+
<canvas id="roleChart"></canvas>
|
| 513 |
+
</div>
|
| 514 |
+
</div>
|
| 515 |
+
</div>
|
| 516 |
+
|
| 517 |
+
<div class="panel" style="margin-top: 2rem;">
|
| 518 |
+
<div class="panel-title">Key Structural Insights</div>
|
| 519 |
+
<div style="line-height: 1.6; display: grid; grid-template-columns: 1fr 1fr; gap: 2.5rem;">
|
| 520 |
+
<div>
|
| 521 |
+
<h3 style="margin-bottom: 0.5rem; color: var(--secondary);">🔬 Multiplexed Chip Architecture</h3>
|
| 522 |
+
<p style="color: var(--text-muted); margin-bottom: 1.25rem;">
|
| 523 |
+
Each physical device runs exactly <strong>one cell line</strong>. This eliminates cell mixing within a single microfluidic chip, enabling clean downstream sorting. However, multiple chemical libraries are pooled on each chip (ranging from 2 to 8 libraries per device).
|
| 524 |
+
</p>
|
| 525 |
+
</div>
|
| 526 |
+
<div>
|
| 527 |
+
<h3 style="margin-bottom: 0.5rem; color: var(--accent);">🧪 Named Control Compounds vs. Combinatorial Libraries</h3>
|
| 528 |
+
<p style="color: var(--text-muted); margin-bottom: 1.25rem;">
|
| 529 |
+
The screen features a split between **One-Bead One-Compound (OBOC) combinatorial libraries** (testing 142.1k chemical precursor fragments across 353.3k wells) and **Named Control Compounds** (testing 78 fully synthesized target compounds across 311.3k wells).
|
| 530 |
+
</p>
|
| 531 |
+
<h3 style="margin-bottom: 0.5rem; color: var(--primary);">🛡️ No-Compound Control Beads</h3>
|
| 532 |
+
<p style="color: var(--text-muted);">
|
| 533 |
+
Out of 49 devices, <strong>24 devices</strong> contain no-compound controls (including capture-only control bead library `ZEL026-2` and water/vehicle controls like `ZIC005`). Only <strong>Device 11</strong> lacks control beads entirely, profiling named control compounds exclusively.
|
| 534 |
+
</p>
|
| 535 |
+
</div>
|
| 536 |
+
</div>
|
| 537 |
+
</div>
|
| 538 |
+
</div>
|
| 539 |
+
|
| 540 |
+
<!-- MATRIX TAB -->
|
| 541 |
+
<div id="tab-matrix" class="tab-content">
|
| 542 |
+
<div class="panel">
|
| 543 |
+
<div class="panel-title">
|
| 544 |
+
<div>
|
| 545 |
+
Screening Matrix Map
|
| 546 |
+
<div class="panel-subtitle">Nanowell counts mapped per library (rows) and cell line (columns)</div>
|
| 547 |
+
</div>
|
| 548 |
+
</div>
|
| 549 |
+
<div class="heatmap-container">
|
| 550 |
+
<div class="heatmap-grid" id="heatmapGrid">
|
| 551 |
+
<!-- JS populated -->
|
| 552 |
+
</div>
|
| 553 |
+
<div class="heatmap-legend">
|
| 554 |
+
<div class="legend-item"><div class="legend-color" style="background: rgba(139, 92, 246, 0.05); border: 1px solid var(--border-color);"></div> Not Screened</div>
|
| 555 |
+
<div class="legend-item"><div class="legend-color" style="background: rgba(139, 92, 246, 0.25);"></div> low (< 2,000 wells)</div>
|
| 556 |
+
<div class="legend-item"><div class="legend-color" style="background: rgba(139, 92, 246, 0.55);"></div> medium (2k - 25k wells)</div>
|
| 557 |
+
<div class="legend-item"><div class="legend-color" style="background: rgba(139, 92, 246, 0.85);"></div> high (> 25k wells)</div>
|
| 558 |
+
</div>
|
| 559 |
+
</div>
|
| 560 |
+
</div>
|
| 561 |
+
</div>
|
| 562 |
+
|
| 563 |
+
<!-- DEVICES TAB -->
|
| 564 |
+
<div id="tab-devices" class="tab-content">
|
| 565 |
+
<div class="panel">
|
| 566 |
+
<div class="panel-title">
|
| 567 |
+
<div>
|
| 568 |
+
Device-Level Screen Map
|
| 569 |
+
<div class="panel-subtitle">Search, filter, and inspect cell line labels and pooled libraries per device</div>
|
| 570 |
+
</div>
|
| 571 |
+
</div>
|
| 572 |
+
|
| 573 |
+
<div class="search-box">
|
| 574 |
+
<input type="text" id="deviceSearch" class="search-input" placeholder="Search devices by ID, cell line, or library..." oninput="filterDevices()">
|
| 575 |
+
<select id="cellLineFilter" class="filter-select" onchange="filterDevices()">
|
| 576 |
+
<option value="">All Cell Lines</option>
|
| 577 |
+
<option value="HEK293">HEK293</option>
|
| 578 |
+
<option value="HEK293-clone">HEK293-clone</option>
|
| 579 |
+
<option value="A549">A549</option>
|
| 580 |
+
<option value="H1650">H1650</option>
|
| 581 |
+
<option value="THP1">THP1</option>
|
| 582 |
+
<option value="AEC7">AEC7</option>
|
| 583 |
+
</select>
|
| 584 |
+
</div>
|
| 585 |
+
|
| 586 |
+
<div class="table-wrapper">
|
| 587 |
+
<table id="deviceTable">
|
| 588 |
+
<thead>
|
| 589 |
+
<tr>
|
| 590 |
+
<th>Device ID</th>
|
| 591 |
+
<th>Cell Line</th>
|
| 592 |
+
<th>Libraries Screened</th>
|
| 593 |
+
<th>Nanowell Count</th>
|
| 594 |
+
<th>Treatment Split</th>
|
| 595 |
+
</tr>
|
| 596 |
+
</thead>
|
| 597 |
+
<tbody id="deviceTableBody">
|
| 598 |
+
<!-- JS populated -->
|
| 599 |
+
</tbody>
|
| 600 |
+
</table>
|
| 601 |
+
</div>
|
| 602 |
+
</div>
|
| 603 |
+
</div>
|
| 604 |
+
|
| 605 |
+
<!-- LIBRARIES TAB -->
|
| 606 |
+
<div id="tab-libraries" class="tab-content">
|
| 607 |
+
<div class="panel">
|
| 608 |
+
<div class="panel-title">
|
| 609 |
+
<div>
|
| 610 |
+
Screened Chemical Libraries & Control Sets
|
| 611 |
+
<div class="panel-subtitle">Details of compound counts, SMILES configurations, and nomenclature types</div>
|
| 612 |
+
</div>
|
| 613 |
+
</div>
|
| 614 |
+
<div class="lib-grid" id="libGrid">
|
| 615 |
+
<!-- JS populated -->
|
| 616 |
+
</div>
|
| 617 |
+
</div>
|
| 618 |
+
</div>
|
| 619 |
+
|
| 620 |
+
</div>
|
| 621 |
+
|
| 622 |
+
<script>
|
| 623 |
+
// Embedded JSON structures
|
| 624 |
+
const results = {
|
| 625 |
+
"compounds_per_library": {
|
| 626 |
+
"ZIC008": {
|
| 627 |
+
"unique_public_compound_ids": 35,
|
| 628 |
+
"unique_smiles": 35,
|
| 629 |
+
"unique_names": 35,
|
| 630 |
+
"condition_roles": {
|
| 631 |
+
"compound_treatment": 256052
|
| 632 |
+
}
|
| 633 |
+
},
|
| 634 |
+
"ZEL026-2": {
|
| 635 |
+
"unique_public_compound_ids": 0,
|
| 636 |
+
"unique_smiles": 0,
|
| 637 |
+
"unique_names": 1,
|
| 638 |
+
"condition_roles": {
|
| 639 |
+
"capture_only": 95583
|
| 640 |
+
}
|
| 641 |
+
},
|
| 642 |
+
"ZEL031": {
|
| 643 |
+
"unique_public_compound_ids": 10265,
|
| 644 |
+
"unique_smiles": 10265,
|
| 645 |
+
"unique_names": 1,
|
| 646 |
+
"condition_roles": {
|
| 647 |
+
"building_block_treatment": 43241
|
| 648 |
+
}
|
| 649 |
+
},
|
| 650 |
+
"ZEL028-2": {
|
| 651 |
+
"unique_public_compound_ids": 117950,
|
| 652 |
+
"unique_smiles": 117950,
|
| 653 |
+
"unique_names": 1,
|
| 654 |
+
"condition_roles": {
|
| 655 |
+
"building_block_treatment": 134821
|
| 656 |
+
}
|
| 657 |
+
},
|
| 658 |
+
"ZIC004": {
|
| 659 |
+
"unique_public_compound_ids": 1,
|
| 660 |
+
"unique_smiles": 1,
|
| 661 |
+
"unique_names": 1,
|
| 662 |
+
"condition_roles": {
|
| 663 |
+
"compound_treatment": 1913
|
| 664 |
+
}
|
| 665 |
+
},
|
| 666 |
+
"ZIC006": {
|
| 667 |
+
"unique_public_compound_ids": 1,
|
| 668 |
+
"unique_smiles": 1,
|
| 669 |
+
"unique_names": 1,
|
| 670 |
+
"condition_roles": {
|
| 671 |
+
"compound_treatment": 2099
|
| 672 |
+
}
|
| 673 |
+
},
|
| 674 |
+
"ZIC003": {
|
| 675 |
+
"unique_public_compound_ids": 2,
|
| 676 |
+
"unique_smiles": 2,
|
| 677 |
+
"unique_names": 2,
|
| 678 |
+
"condition_roles": {
|
| 679 |
+
"compound_treatment": 1880
|
| 680 |
+
}
|
| 681 |
+
},
|
| 682 |
+
"ZIC002": {
|
| 683 |
+
"unique_public_compound_ids": 7,
|
| 684 |
+
"unique_smiles": 7,
|
| 685 |
+
"unique_names": 7,
|
| 686 |
+
"condition_roles": {
|
| 687 |
+
"compound_treatment": 10999
|
| 688 |
+
}
|
| 689 |
+
},
|
| 690 |
+
"ZIC001": {
|
| 691 |
+
"unique_public_compound_ids": 2,
|
| 692 |
+
"unique_smiles": 2,
|
| 693 |
+
"unique_names": 2,
|
| 694 |
+
"condition_roles": {
|
| 695 |
+
"compound_treatment": 6569
|
| 696 |
+
}
|
| 697 |
+
},
|
| 698 |
+
"ZEL024": {
|
| 699 |
+
"unique_public_compound_ids": 13934,
|
| 700 |
+
"unique_smiles": 13934,
|
| 701 |
+
"unique_names": 1,
|
| 702 |
+
"condition_roles": {
|
| 703 |
+
"building_block_treatment": 175285
|
| 704 |
+
}
|
| 705 |
+
},
|
| 706 |
+
"ZIC005": {
|
| 707 |
+
"unique_public_compound_ids": 1,
|
| 708 |
+
"unique_smiles": 0,
|
| 709 |
+
"unique_names": 1,
|
| 710 |
+
"condition_roles": {
|
| 711 |
+
"compound_treatment": 157
|
| 712 |
+
}
|
| 713 |
+
},
|
| 714 |
+
"ZIC007": {
|
| 715 |
+
"unique_public_compound_ids": 4,
|
| 716 |
+
"unique_smiles": 4,
|
| 717 |
+
"unique_names": 4,
|
| 718 |
+
"condition_roles": {
|
| 719 |
+
"compound_treatment": 565
|
| 720 |
+
}
|
| 721 |
+
},
|
| 722 |
+
"ZIC009": {
|
| 723 |
+
"unique_public_compound_ids": 31,
|
| 724 |
+
"unique_smiles": 31,
|
| 725 |
+
"unique_names": 31,
|
| 726 |
+
"condition_roles": {
|
| 727 |
+
"compound_treatment": 31107
|
| 728 |
+
}
|
| 729 |
+
},
|
| 730 |
+
"ZIC005-2": {
|
| 731 |
+
"unique_public_compound_ids": 0,
|
| 732 |
+
"unique_smiles": 0,
|
| 733 |
+
"unique_names": 1,
|
| 734 |
+
"condition_roles": {
|
| 735 |
+
"capture_only": 7891
|
| 736 |
+
}
|
| 737 |
+
}
|
| 738 |
+
},
|
| 739 |
+
"cell_lines": {
|
| 740 |
+
"list": [
|
| 741 |
+
"HEK293-clone",
|
| 742 |
+
"A549",
|
| 743 |
+
"H1650",
|
| 744 |
+
"HEK293",
|
| 745 |
+
"THP1",
|
| 746 |
+
"AEC7"
|
| 747 |
+
],
|
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|
| 1210 |
+
"ZEL026-2",
|
| 1211 |
+
"ZIC009"
|
| 1212 |
+
],
|
| 1213 |
+
"37": [
|
| 1214 |
+
"ZIC008",
|
| 1215 |
+
"ZEL026-2",
|
| 1216 |
+
"ZIC009"
|
| 1217 |
+
],
|
| 1218 |
+
"38": [
|
| 1219 |
+
"ZEL026-2",
|
| 1220 |
+
"ZIC008",
|
| 1221 |
+
"ZIC009"
|
| 1222 |
+
],
|
| 1223 |
+
"39": [
|
| 1224 |
+
"ZIC008",
|
| 1225 |
+
"ZEL026-2",
|
| 1226 |
+
"ZIC009"
|
| 1227 |
+
],
|
| 1228 |
+
"40": [
|
| 1229 |
+
"ZIC008",
|
| 1230 |
+
"ZEL026-2",
|
| 1231 |
+
"ZIC009"
|
| 1232 |
+
],
|
| 1233 |
+
"41": [
|
| 1234 |
+
"ZIC008",
|
| 1235 |
+
"ZIC005-2",
|
| 1236 |
+
"ZIC009"
|
| 1237 |
+
],
|
| 1238 |
+
"42": [
|
| 1239 |
+
"ZIC008",
|
| 1240 |
+
"ZIC009",
|
| 1241 |
+
"ZIC005-2"
|
| 1242 |
+
],
|
| 1243 |
+
"43": [
|
| 1244 |
+
"ZIC008",
|
| 1245 |
+
"ZIC005-2",
|
| 1246 |
+
"ZIC009"
|
| 1247 |
+
],
|
| 1248 |
+
"44": [
|
| 1249 |
+
"ZIC008",
|
| 1250 |
+
"ZIC005-2",
|
| 1251 |
+
"ZIC009"
|
| 1252 |
+
],
|
| 1253 |
+
"45": [
|
| 1254 |
+
"ZIC008",
|
| 1255 |
+
"ZIC005-2",
|
| 1256 |
+
"ZIC009"
|
| 1257 |
+
],
|
| 1258 |
+
"46": [
|
| 1259 |
+
"ZIC008",
|
| 1260 |
+
"ZIC005-2",
|
| 1261 |
+
"ZIC009"
|
| 1262 |
+
],
|
| 1263 |
+
"47": [
|
| 1264 |
+
"ZIC008",
|
| 1265 |
+
"ZIC009",
|
| 1266 |
+
"ZIC005-2"
|
| 1267 |
+
],
|
| 1268 |
+
"48": [
|
| 1269 |
+
"ZIC008",
|
| 1270 |
+
"ZIC005-2",
|
| 1271 |
+
"ZIC009"
|
| 1272 |
+
]
|
| 1273 |
+
},
|
| 1274 |
+
"is_each_device_single_library": false,
|
| 1275 |
+
"device_condition_roles": {
|
| 1276 |
+
"0": {
|
| 1277 |
+
"building_block_treatment": 25310,
|
| 1278 |
+
"compound_treatment": 2051
|
| 1279 |
+
},
|
| 1280 |
+
"1": {
|
| 1281 |
+
"building_block_treatment": 20398,
|
| 1282 |
+
"compound_treatment": 1613
|
| 1283 |
+
},
|
| 1284 |
+
"2": {
|
| 1285 |
+
"building_block_treatment": 30307,
|
| 1286 |
+
"compound_treatment": 2599
|
| 1287 |
+
},
|
| 1288 |
+
"3": {
|
| 1289 |
+
"building_block_treatment": 28064,
|
| 1290 |
+
"compound_treatment": 2454
|
| 1291 |
+
},
|
| 1292 |
+
"4": {
|
| 1293 |
+
"building_block_treatment": 26973,
|
| 1294 |
+
"compound_treatment": 3040
|
| 1295 |
+
},
|
| 1296 |
+
"5": {
|
| 1297 |
+
"building_block_treatment": 22688,
|
| 1298 |
+
"compound_treatment": 2578
|
| 1299 |
+
},
|
| 1300 |
+
"6": {
|
| 1301 |
+
"building_block_treatment": 19253,
|
| 1302 |
+
"compound_treatment": 846
|
| 1303 |
+
},
|
| 1304 |
+
"7": {
|
| 1305 |
+
"building_block_treatment": 2292,
|
| 1306 |
+
"compound_treatment": 263
|
| 1307 |
+
},
|
| 1308 |
+
"8": {
|
| 1309 |
+
"capture_only": 10369,
|
| 1310 |
+
"compound_treatment": 2053
|
| 1311 |
+
},
|
| 1312 |
+
"9": {
|
| 1313 |
+
"capture_only": 6717,
|
| 1314 |
+
"compound_treatment": 854
|
| 1315 |
+
},
|
| 1316 |
+
"10": {
|
| 1317 |
+
"building_block_treatment": 2837,
|
| 1318 |
+
"compound_treatment": 911
|
| 1319 |
+
},
|
| 1320 |
+
"11": {
|
| 1321 |
+
"compound_treatment": 257
|
| 1322 |
+
},
|
| 1323 |
+
"12": {
|
| 1324 |
+
"building_block_treatment": 19105,
|
| 1325 |
+
"compound_treatment": 4591
|
| 1326 |
+
},
|
| 1327 |
+
"13": {
|
| 1328 |
+
"compound_treatment": 7771,
|
| 1329 |
+
"building_block_treatment": 5831
|
| 1330 |
+
},
|
| 1331 |
+
"14": {
|
| 1332 |
+
"compound_treatment": 5583,
|
| 1333 |
+
"building_block_treatment": 4295
|
| 1334 |
+
},
|
| 1335 |
+
"15": {
|
| 1336 |
+
"compound_treatment": 11376,
|
| 1337 |
+
"building_block_treatment": 5522
|
| 1338 |
+
},
|
| 1339 |
+
"16": {
|
| 1340 |
+
"compound_treatment": 7041,
|
| 1341 |
+
"building_block_treatment": 5220
|
| 1342 |
+
},
|
| 1343 |
+
"17": {
|
| 1344 |
+
"compound_treatment": 9757,
|
| 1345 |
+
"capture_only": 3918
|
| 1346 |
+
},
|
| 1347 |
+
"18": {
|
| 1348 |
+
"compound_treatment": 8428,
|
| 1349 |
+
"capture_only": 2904
|
| 1350 |
+
},
|
| 1351 |
+
"19": {
|
| 1352 |
+
"compound_treatment": 6283,
|
| 1353 |
+
"building_block_treatment": 107
|
| 1354 |
+
},
|
| 1355 |
+
"20": {
|
| 1356 |
+
"compound_treatment": 13903,
|
| 1357 |
+
"building_block_treatment": 324
|
| 1358 |
+
},
|
| 1359 |
+
"21": {
|
| 1360 |
+
"compound_treatment": 15125,
|
| 1361 |
+
"capture_only": 12714
|
| 1362 |
+
},
|
| 1363 |
+
"22": {
|
| 1364 |
+
"compound_treatment": 11058,
|
| 1365 |
+
"capture_only": 7182
|
| 1366 |
+
},
|
| 1367 |
+
"23": {
|
| 1368 |
+
"building_block_treatment": 20152,
|
| 1369 |
+
"compound_treatment": 3456
|
| 1370 |
+
},
|
| 1371 |
+
"24": {
|
| 1372 |
+
"building_block_treatment": 12056,
|
| 1373 |
+
"compound_treatment": 2122
|
| 1374 |
+
},
|
| 1375 |
+
"25": {
|
| 1376 |
+
"building_block_treatment": 22283,
|
| 1377 |
+
"compound_treatment": 5429
|
| 1378 |
+
},
|
| 1379 |
+
"26": {
|
| 1380 |
+
"building_block_treatment": 14638,
|
| 1381 |
+
"compound_treatment": 4074
|
| 1382 |
+
},
|
| 1383 |
+
"27": {
|
| 1384 |
+
"building_block_treatment": 14494,
|
| 1385 |
+
"compound_treatment": 3505
|
| 1386 |
+
},
|
| 1387 |
+
"28": {
|
| 1388 |
+
"building_block_treatment": 12865,
|
| 1389 |
+
"compound_treatment": 2943
|
| 1390 |
+
},
|
| 1391 |
+
"29": {
|
| 1392 |
+
"compound_treatment": 19951,
|
| 1393 |
+
"capture_only": 7878
|
| 1394 |
+
},
|
| 1395 |
+
"30": {
|
| 1396 |
+
"compound_treatment": 14309,
|
| 1397 |
+
"capture_only": 7074
|
| 1398 |
+
},
|
| 1399 |
+
"31": {
|
| 1400 |
+
"building_block_treatment": 20770,
|
| 1401 |
+
"compound_treatment": 6751
|
| 1402 |
+
},
|
| 1403 |
+
"32": {
|
| 1404 |
+
"building_block_treatment": 17563,
|
| 1405 |
+
"compound_treatment": 5811
|
| 1406 |
+
},
|
| 1407 |
+
"33": {
|
| 1408 |
+
"compound_treatment": 7910,
|
| 1409 |
+
"capture_only": 3588
|
| 1410 |
+
},
|
| 1411 |
+
"34": {
|
| 1412 |
+
"compound_treatment": 7340,
|
| 1413 |
+
"capture_only": 3910
|
| 1414 |
+
},
|
| 1415 |
+
"35": {
|
| 1416 |
+
"compound_treatment": 6075,
|
| 1417 |
+
"capture_only": 3090
|
| 1418 |
+
},
|
| 1419 |
+
"36": {
|
| 1420 |
+
"compound_treatment": 8004,
|
| 1421 |
+
"capture_only": 4107
|
| 1422 |
+
},
|
| 1423 |
+
"37": {
|
| 1424 |
+
"compound_treatment": 9358,
|
| 1425 |
+
"capture_only": 4032
|
| 1426 |
+
},
|
| 1427 |
+
"38": {
|
| 1428 |
+
"compound_treatment": 12360,
|
| 1429 |
+
"capture_only": 5144
|
| 1430 |
+
},
|
| 1431 |
+
"39": {
|
| 1432 |
+
"compound_treatment": 13801,
|
| 1433 |
+
"capture_only": 7391
|
| 1434 |
+
},
|
| 1435 |
+
"40": {
|
| 1436 |
+
"compound_treatment": 10753,
|
| 1437 |
+
"capture_only": 5565
|
| 1438 |
+
},
|
| 1439 |
+
"41": {
|
| 1440 |
+
"compound_treatment": 2587,
|
| 1441 |
+
"capture_only": 342
|
| 1442 |
+
},
|
| 1443 |
+
"42": {
|
| 1444 |
+
"compound_treatment": 3990,
|
| 1445 |
+
"capture_only": 670
|
| 1446 |
+
},
|
| 1447 |
+
"43": {
|
| 1448 |
+
"compound_treatment": 9698,
|
| 1449 |
+
"capture_only": 1839
|
| 1450 |
+
},
|
| 1451 |
+
"44": {
|
| 1452 |
+
"compound_treatment": 8618,
|
| 1453 |
+
"capture_only": 1854
|
| 1454 |
+
},
|
| 1455 |
+
"45": {
|
| 1456 |
+
"compound_treatment": 6209,
|
| 1457 |
+
"capture_only": 1014
|
| 1458 |
+
},
|
| 1459 |
+
"46": {
|
| 1460 |
+
"compound_treatment": 7242,
|
| 1461 |
+
"capture_only": 1016
|
| 1462 |
+
},
|
| 1463 |
+
"47": {
|
| 1464 |
+
"compound_treatment": 5136,
|
| 1465 |
+
"capture_only": 847
|
| 1466 |
+
},
|
| 1467 |
+
"48": {
|
| 1468 |
+
"compound_treatment": 3474,
|
| 1469 |
+
"capture_only": 309
|
| 1470 |
+
}
|
| 1471 |
+
},
|
| 1472 |
+
"no_compound_control_summary": {
|
| 1473 |
+
"devices_with_capture_only": {
|
| 1474 |
+
"list": [
|
| 1475 |
+
8,
|
| 1476 |
+
9,
|
| 1477 |
+
17,
|
| 1478 |
+
18,
|
| 1479 |
+
21,
|
| 1480 |
+
22,
|
| 1481 |
+
29,
|
| 1482 |
+
30,
|
| 1483 |
+
33,
|
| 1484 |
+
34,
|
| 1485 |
+
35,
|
| 1486 |
+
36,
|
| 1487 |
+
37,
|
| 1488 |
+
38,
|
| 1489 |
+
39,
|
| 1490 |
+
40,
|
| 1491 |
+
41,
|
| 1492 |
+
42,
|
| 1493 |
+
43,
|
| 1494 |
+
44,
|
| 1495 |
+
45,
|
| 1496 |
+
46,
|
| 1497 |
+
47,
|
| 1498 |
+
48
|
| 1499 |
+
],
|
| 1500 |
+
"count": 24
|
| 1501 |
+
},
|
| 1502 |
+
"devices_with_building_block_treatment": {
|
| 1503 |
+
"list": [
|
| 1504 |
+
0,
|
| 1505 |
+
1,
|
| 1506 |
+
2,
|
| 1507 |
+
3,
|
| 1508 |
+
4,
|
| 1509 |
+
5,
|
| 1510 |
+
6,
|
| 1511 |
+
7,
|
| 1512 |
+
10,
|
| 1513 |
+
12,
|
| 1514 |
+
13,
|
| 1515 |
+
14,
|
| 1516 |
+
15,
|
| 1517 |
+
16,
|
| 1518 |
+
19,
|
| 1519 |
+
20,
|
| 1520 |
+
23,
|
| 1521 |
+
24,
|
| 1522 |
+
25,
|
| 1523 |
+
26,
|
| 1524 |
+
27,
|
| 1525 |
+
28,
|
| 1526 |
+
31,
|
| 1527 |
+
32
|
| 1528 |
+
],
|
| 1529 |
+
"count": 24
|
| 1530 |
+
}
|
| 1531 |
+
}
|
| 1532 |
+
};
|
| 1533 |
+
const crosstab = {
|
| 1534 |
+
"ZEL024": {
|
| 1535 |
+
"A549": 0,
|
| 1536 |
+
"AEC7": 0,
|
| 1537 |
+
"H1650": 21545,
|
| 1538 |
+
"HEK293": 153740,
|
| 1539 |
+
"HEK293-clone": 0,
|
| 1540 |
+
"THP1": 0
|
| 1541 |
+
},
|
| 1542 |
+
"ZEL026-2": {
|
| 1543 |
+
"A549": 26718,
|
| 1544 |
+
"AEC7": 36827,
|
| 1545 |
+
"H1650": 17086,
|
| 1546 |
+
"HEK293": 0,
|
| 1547 |
+
"HEK293-clone": 14952,
|
| 1548 |
+
"THP1": 0
|
| 1549 |
+
},
|
| 1550 |
+
"ZEL028-2": {
|
| 1551 |
+
"A549": 42435,
|
| 1552 |
+
"AEC7": 0,
|
| 1553 |
+
"H1650": 26694,
|
| 1554 |
+
"HEK293": 65692,
|
| 1555 |
+
"HEK293-clone": 0,
|
| 1556 |
+
"THP1": 0
|
| 1557 |
+
},
|
| 1558 |
+
"ZEL031": {
|
| 1559 |
+
"A549": 20868,
|
| 1560 |
+
"AEC7": 0,
|
| 1561 |
+
"H1650": 431,
|
| 1562 |
+
"HEK293": 0,
|
| 1563 |
+
"HEK293-clone": 0,
|
| 1564 |
+
"THP1": 21942
|
| 1565 |
+
},
|
| 1566 |
+
"ZIC001": {
|
| 1567 |
+
"A549": 0,
|
| 1568 |
+
"AEC7": 0,
|
| 1569 |
+
"H1650": 1229,
|
| 1570 |
+
"HEK293": 3858,
|
| 1571 |
+
"HEK293-clone": 0,
|
| 1572 |
+
"THP1": 1482
|
| 1573 |
+
},
|
| 1574 |
+
"ZIC002": {
|
| 1575 |
+
"A549": 0,
|
| 1576 |
+
"AEC7": 0,
|
| 1577 |
+
"H1650": 806,
|
| 1578 |
+
"HEK293": 9558,
|
| 1579 |
+
"HEK293-clone": 0,
|
| 1580 |
+
"THP1": 635
|
| 1581 |
+
},
|
| 1582 |
+
"ZIC003": {
|
| 1583 |
+
"A549": 0,
|
| 1584 |
+
"AEC7": 0,
|
| 1585 |
+
"H1650": 378,
|
| 1586 |
+
"HEK293": 919,
|
| 1587 |
+
"HEK293-clone": 0,
|
| 1588 |
+
"THP1": 583
|
| 1589 |
+
},
|
| 1590 |
+
"ZIC004": {
|
| 1591 |
+
"A549": 122,
|
| 1592 |
+
"AEC7": 0,
|
| 1593 |
+
"H1650": 411,
|
| 1594 |
+
"HEK293": 0,
|
| 1595 |
+
"HEK293-clone": 0,
|
| 1596 |
+
"THP1": 1380
|
| 1597 |
+
},
|
| 1598 |
+
"ZIC005": {
|
| 1599 |
+
"A549": 0,
|
| 1600 |
+
"AEC7": 0,
|
| 1601 |
+
"H1650": 109,
|
| 1602 |
+
"HEK293": 0,
|
| 1603 |
+
"HEK293-clone": 0,
|
| 1604 |
+
"THP1": 48
|
| 1605 |
+
},
|
| 1606 |
+
"ZIC005-2": {
|
| 1607 |
+
"A549": 0,
|
| 1608 |
+
"AEC7": 7891,
|
| 1609 |
+
"H1650": 0,
|
| 1610 |
+
"HEK293": 0,
|
| 1611 |
+
"HEK293-clone": 0,
|
| 1612 |
+
"THP1": 0
|
| 1613 |
+
},
|
| 1614 |
+
"ZIC006": {
|
| 1615 |
+
"A549": 207,
|
| 1616 |
+
"AEC7": 0,
|
| 1617 |
+
"H1650": 631,
|
| 1618 |
+
"HEK293": 0,
|
| 1619 |
+
"HEK293-clone": 0,
|
| 1620 |
+
"THP1": 1261
|
| 1621 |
+
},
|
| 1622 |
+
"ZIC007": {
|
| 1623 |
+
"A549": 0,
|
| 1624 |
+
"AEC7": 0,
|
| 1625 |
+
"H1650": 452,
|
| 1626 |
+
"HEK293": 0,
|
| 1627 |
+
"HEK293-clone": 0,
|
| 1628 |
+
"THP1": 113
|
| 1629 |
+
},
|
| 1630 |
+
"ZIC008": {
|
| 1631 |
+
"A549": 84952,
|
| 1632 |
+
"AEC7": 91448,
|
| 1633 |
+
"H1650": 26382,
|
| 1634 |
+
"HEK293": 19010,
|
| 1635 |
+
"HEK293-clone": 34260,
|
| 1636 |
+
"THP1": 0
|
| 1637 |
+
},
|
| 1638 |
+
"ZIC009": {
|
| 1639 |
+
"A549": 0,
|
| 1640 |
+
"AEC7": 31107,
|
| 1641 |
+
"H1650": 0,
|
| 1642 |
+
"HEK293": 0,
|
| 1643 |
+
"HEK293-clone": 0,
|
| 1644 |
+
"THP1": 0
|
| 1645 |
+
}
|
| 1646 |
+
};
|
| 1647 |
+
|
| 1648 |
+
function switchTab(tabId) {
|
| 1649 |
+
document.querySelectorAll('.tab-content').forEach(el => el.classList.remove('active'));
|
| 1650 |
+
document.querySelectorAll('.tab-btn').forEach(el => el.classList.remove('active'));
|
| 1651 |
+
|
| 1652 |
+
document.getElementById(tabId).classList.add('active');
|
| 1653 |
+
// Find corresponding button
|
| 1654 |
+
const btnText = tabId.replace('tab-', '').toLowerCase();
|
| 1655 |
+
document.querySelectorAll('.tab-btn').forEach(btn => {
|
| 1656 |
+
if (btn.innerText.toLowerCase() === btnText || (btnText === 'matrix' && btn.innerText.toLowerCase() === 'screen matrix')) {
|
| 1657 |
+
btn.classList.add('active');
|
| 1658 |
+
}
|
| 1659 |
+
});
|
| 1660 |
+
}
|
| 1661 |
+
|
| 1662 |
+
// Initialize charts
|
| 1663 |
+
window.onload = function() {
|
| 1664 |
+
// Cell Line chart
|
| 1665 |
+
const ctxCell = document.getElementById('cellLineChart').getContext('2d');
|
| 1666 |
+
new Chart(ctxCell, {
|
| 1667 |
+
type: 'bar',
|
| 1668 |
+
data: {
|
| 1669 |
+
labels: ['HEK293', 'A549', 'AEC7', 'H1650', 'HEK293-clone', 'THP1'],
|
| 1670 |
+
datasets: [{
|
| 1671 |
+
label: 'Nanowells Profiled',
|
| 1672 |
+
data: [252777, 175302, 167273, 96154, 49212, 27444],
|
| 1673 |
+
backgroundColor: ['#8b5cf6', '#06b6d4', '#ec4899', '#f97316', '#e5e7eb', '#10b981'],
|
| 1674 |
+
borderColor: 'rgba(255, 255, 255, 0.1)',
|
| 1675 |
+
borderWidth: 1,
|
| 1676 |
+
borderRadius: 8
|
| 1677 |
+
}]
|
| 1678 |
+
},
|
| 1679 |
+
options: {
|
| 1680 |
+
responsive: true,
|
| 1681 |
+
maintainAspectRatio: false,
|
| 1682 |
+
plugins: {
|
| 1683 |
+
legend: { display: false }
|
| 1684 |
+
},
|
| 1685 |
+
scales: {
|
| 1686 |
+
y: {
|
| 1687 |
+
grid: { color: 'rgba(255, 255, 255, 0.05)' },
|
| 1688 |
+
ticks: { color: '#9ca3af', font: { family: 'Outfit' } }
|
| 1689 |
+
},
|
| 1690 |
+
x: {
|
| 1691 |
+
grid: { display: false },
|
| 1692 |
+
ticks: { color: '#9ca3af', font: { family: 'Outfit', weight: 'bold' } }
|
| 1693 |
+
}
|
| 1694 |
+
}
|
| 1695 |
+
}
|
| 1696 |
+
});
|
| 1697 |
+
|
| 1698 |
+
// Role split chart
|
| 1699 |
+
const ctxRole = document.getElementById('roleChart').getContext('2d');
|
| 1700 |
+
new Chart(ctxRole, {
|
| 1701 |
+
type: 'doughnut',
|
| 1702 |
+
data: {
|
| 1703 |
+
labels: ['OBOC Combinatorial Libraries', 'Named Control Compounds', 'No-Compound Controls'],
|
| 1704 |
+
datasets: [{
|
| 1705 |
+
data: [353347, 311341, 103474],
|
| 1706 |
+
backgroundColor: ['#8b5cf6', '#06b6d4', '#f43f5e'],
|
| 1707 |
+
borderWidth: 0,
|
| 1708 |
+
hoverOffset: 10
|
| 1709 |
+
}]
|
| 1710 |
+
},
|
| 1711 |
+
options: {
|
| 1712 |
+
responsive: true,
|
| 1713 |
+
maintainAspectRatio: false,
|
| 1714 |
+
plugins: {
|
| 1715 |
+
legend: {
|
| 1716 |
+
position: 'bottom',
|
| 1717 |
+
labels: {
|
| 1718 |
+
color: '#e5e7eb',
|
| 1719 |
+
font: { family: 'Outfit', size: 12 },
|
| 1720 |
+
padding: 15
|
| 1721 |
+
}
|
| 1722 |
+
}
|
| 1723 |
+
},
|
| 1724 |
+
cutout: '65%'
|
| 1725 |
+
}
|
| 1726 |
+
});
|
| 1727 |
+
|
| 1728 |
+
buildHeatmap();
|
| 1729 |
+
buildDeviceTable();
|
| 1730 |
+
buildLibraryCards();
|
| 1731 |
+
};
|
| 1732 |
+
|
| 1733 |
+
// Build the matrix heatmap
|
| 1734 |
+
function buildHeatmap() {
|
| 1735 |
+
const grid = document.getElementById('heatmapGrid');
|
| 1736 |
+
const cellLines = ['A549', 'AEC7', 'H1650', 'HEK293', 'HEK293-clone', 'THP1'];
|
| 1737 |
+
|
| 1738 |
+
// Header
|
| 1739 |
+
grid.appendChild(createDiv('heatmap-header-cell', ''));
|
| 1740 |
+
cellLines.forEach(cell => {
|
| 1741 |
+
grid.appendChild(createDiv('heatmap-header-cell', cell));
|
| 1742 |
+
});
|
| 1743 |
+
|
| 1744 |
+
// Grid rows
|
| 1745 |
+
Object.keys(crosstab).sort().forEach(lib => {
|
| 1746 |
+
// Label
|
| 1747 |
+
grid.appendChild(createDiv('heatmap-label-cell', lib));
|
| 1748 |
+
|
| 1749 |
+
// Values
|
| 1750 |
+
cellLines.forEach(cell => {
|
| 1751 |
+
const val = crosstab[lib][cell] || 0;
|
| 1752 |
+
const cellEl = document.createElement('div');
|
| 1753 |
+
cellEl.className = 'heatmap-cell';
|
| 1754 |
+
|
| 1755 |
+
// Color scale
|
| 1756 |
+
let bg = 'rgba(139, 92, 246, 0.03)';
|
| 1757 |
+
let color = 'rgba(255, 255, 255, 0.15)';
|
| 1758 |
+
let border = '1px solid var(--border-color)';
|
| 1759 |
+
|
| 1760 |
+
if (val > 0) {
|
| 1761 |
+
border = 'none';
|
| 1762 |
+
if (val < 2000) {
|
| 1763 |
+
bg = 'rgba(139, 92, 246, 0.25)';
|
| 1764 |
+
color = '#d8b4fe';
|
| 1765 |
+
} else if (val < 25000) {
|
| 1766 |
+
bg = 'rgba(139, 92, 246, 0.55)';
|
| 1767 |
+
color = '#e9d5ff';
|
| 1768 |
+
} else {
|
| 1769 |
+
bg = 'rgba(139, 92, 246, 0.85)';
|
| 1770 |
+
color = '#ffffff';
|
| 1771 |
+
}
|
| 1772 |
+
}
|
| 1773 |
+
|
| 1774 |
+
cellEl.style.background = bg;
|
| 1775 |
+
cellEl.style.color = color;
|
| 1776 |
+
cellEl.style.border = border;
|
| 1777 |
+
|
| 1778 |
+
const valSpan = document.createElement('span');
|
| 1779 |
+
valSpan.className = 'heatmap-cell-value';
|
| 1780 |
+
valSpan.innerText = val > 0 ? val.toLocaleString() : '-';
|
| 1781 |
+
cellEl.appendChild(valSpan);
|
| 1782 |
+
|
| 1783 |
+
if (val > 0) {
|
| 1784 |
+
const pctSpan = document.createElement('span');
|
| 1785 |
+
pctSpan.className = 'heatmap-cell-pct';
|
| 1786 |
+
pctSpan.innerText = ((val / 768162) * 100).toFixed(1) + '%';
|
| 1787 |
+
cellEl.appendChild(pctSpan);
|
| 1788 |
+
}
|
| 1789 |
+
|
| 1790 |
+
grid.appendChild(cellEl);
|
| 1791 |
+
});
|
| 1792 |
+
});
|
| 1793 |
+
}
|
| 1794 |
+
|
| 1795 |
+
function createDiv(className, text) {
|
| 1796 |
+
const el = document.createElement('div');
|
| 1797 |
+
el.className = className;
|
| 1798 |
+
el.innerText = text;
|
| 1799 |
+
return el;
|
| 1800 |
+
}
|
| 1801 |
+
|
| 1802 |
+
// Build the Device details table
|
| 1803 |
+
function buildDeviceTable() {
|
| 1804 |
+
const tbody = document.getElementById('deviceTableBody');
|
| 1805 |
+
tbody.innerHTML = '';
|
| 1806 |
+
|
| 1807 |
+
const devices = results.devices.list;
|
| 1808 |
+
devices.forEach(dev => {
|
| 1809 |
+
const devStr = dev.toString();
|
| 1810 |
+
const master_c = results.device_cell_lines[devStr][0];
|
| 1811 |
+
|
| 1812 |
+
const libs = results.device_libraries[devStr];
|
| 1813 |
+
const libsBadges = libs.map(lib => {
|
| 1814 |
+
let badgeClass = 'badge-purple';
|
| 1815 |
+
if (lib === 'ZEL026-2') badgeClass = 'badge-rose';
|
| 1816 |
+
else if (lib === 'ZIC005' || lib === 'ZIC005-2') badgeClass = 'badge-blue';
|
| 1817 |
+
else if (lib.startsWith('ZEL')) badgeClass = 'badge-cyan';
|
| 1818 |
+
return `<span class="badge ${badgeClass}" style="margin: 2px;">${lib}</span>`;
|
| 1819 |
+
}).join(' ');
|
| 1820 |
+
|
| 1821 |
+
const roles = results.device_condition_roles[devStr];
|
| 1822 |
+
const cellCount = Object.values(roles).reduce((a, b) => a + b, 0);
|
| 1823 |
+
|
| 1824 |
+
const rolesSplit = Object.keys(roles).map(role => {
|
| 1825 |
+
let colorClass = 'text-muted';
|
| 1826 |
+
let displayName = role;
|
| 1827 |
+
if (role === 'building_block_treatment') {
|
| 1828 |
+
displayName = 'OBOC Library';
|
| 1829 |
+
colorClass = 'color: #a78bfa;';
|
| 1830 |
+
} else if (role === 'compound_treatment') {
|
| 1831 |
+
// Check if device contains ZIC005 (water control)
|
| 1832 |
+
if (libs.includes('ZIC005')) {
|
| 1833 |
+
displayName = 'Named Controls (+Water)';
|
| 1834 |
+
} else {
|
| 1835 |
+
displayName = 'Named Controls';
|
| 1836 |
+
}
|
| 1837 |
+
colorClass = 'color: #22d3ee;';
|
| 1838 |
+
} else if (role === 'capture_only') {
|
| 1839 |
+
displayName = 'No-Compound Control';
|
| 1840 |
+
colorClass = 'color: #f43f5e;';
|
| 1841 |
+
}
|
| 1842 |
+
return `<span style="font-size: 0.8rem; font-family: var(--font-mono); ${colorClass} font-weight:500;">${displayName}: ${roles[role].toLocaleString()}</span>`;
|
| 1843 |
+
}).join('<br>');
|
| 1844 |
+
|
| 1845 |
+
const tr = document.createElement('tr');
|
| 1846 |
+
tr.setAttribute('data-device-id', devStr);
|
| 1847 |
+
tr.setAttribute('data-cell-line-master', master_c);
|
| 1848 |
+
tr.setAttribute('data-libraries', libs.join(','));
|
| 1849 |
+
|
| 1850 |
+
tr.innerHTML = `
|
| 1851 |
+
<td style="font-family: var(--font-mono); font-weight:bold; padding-left: 1.5rem;">#${dev}</td>
|
| 1852 |
+
<td>${master_c}</td>
|
| 1853 |
+
<td>${libsBadges}</td>
|
| 1854 |
+
<td style="font-family: var(--font-mono); font-weight: 500;">${cellCount.toLocaleString()}</td>
|
| 1855 |
+
<td>${rolesSplit}</td>
|
| 1856 |
+
`;
|
| 1857 |
+
tbody.appendChild(tr);
|
| 1858 |
+
});
|
| 1859 |
+
}
|
| 1860 |
+
|
| 1861 |
+
// Filter devices in table
|
| 1862 |
+
function filterDevices() {
|
| 1863 |
+
const q = document.getElementById('deviceSearch').value.toLowerCase();
|
| 1864 |
+
const cellFilter = document.getElementById('cellLineFilter').value;
|
| 1865 |
+
|
| 1866 |
+
const rows = document.querySelectorAll('#deviceTableBody tr');
|
| 1867 |
+
rows.forEach(row => {
|
| 1868 |
+
const devId = row.getAttribute('data-device-id');
|
| 1869 |
+
const masterCell = row.getAttribute('data-cell-line-master');
|
| 1870 |
+
const libs = row.getAttribute('data-libraries').toLowerCase();
|
| 1871 |
+
|
| 1872 |
+
const matchQuery = devId.includes(q) || masterCell.toLowerCase().includes(q) || libs.includes(q);
|
| 1873 |
+
const matchCell = !cellFilter || masterCell === cellFilter;
|
| 1874 |
+
|
| 1875 |
+
if (matchQuery && matchCell) {
|
| 1876 |
+
row.style.display = '';
|
| 1877 |
+
} else {
|
| 1878 |
+
row.style.display = 'none';
|
| 1879 |
+
}
|
| 1880 |
+
});
|
| 1881 |
+
}
|
| 1882 |
+
|
| 1883 |
+
// Build the chemical libraries cards
|
| 1884 |
+
function buildLibraryCards() {
|
| 1885 |
+
const grid = document.getElementById('libGrid');
|
| 1886 |
+
grid.innerHTML = '';
|
| 1887 |
+
|
| 1888 |
+
Object.keys(results.compounds_per_library).sort().forEach(lib => {
|
| 1889 |
+
const details = results.compounds_per_library[lib];
|
| 1890 |
+
const card = document.createElement('div');
|
| 1891 |
+
card.className = 'lib-card';
|
| 1892 |
+
|
| 1893 |
+
// Sum of cells
|
| 1894 |
+
const sumCells = Object.values(details.condition_roles).reduce((a,b)=>a+b, 0);
|
| 1895 |
+
|
| 1896 |
+
// Category label
|
| 1897 |
+
let categoryLabel = '';
|
| 1898 |
+
let badgeClass = 'badge-purple';
|
| 1899 |
+
if (lib === 'ZEL026-2') {
|
| 1900 |
+
categoryLabel = 'No-Compound Control Beads';
|
| 1901 |
+
badgeClass = 'badge-rose';
|
| 1902 |
+
} else if (lib === 'ZIC005' || lib === 'ZIC005-2') {
|
| 1903 |
+
categoryLabel = lib === 'ZIC005' ? 'No-Compound Control (Water)' : 'No-Compound Control';
|
| 1904 |
+
badgeClass = 'badge-blue';
|
| 1905 |
+
} else if (lib.startsWith('ZEL')) {
|
| 1906 |
+
categoryLabel = 'OBOC Combinatorial Library';
|
| 1907 |
+
badgeClass = 'badge-cyan';
|
| 1908 |
+
} else if (lib.startsWith('ZIC')) {
|
| 1909 |
+
categoryLabel = 'Named Control Compounds';
|
| 1910 |
+
badgeClass = 'badge-purple';
|
| 1911 |
+
}
|
| 1912 |
+
|
| 1913 |
+
let roleBadge = `<span class="badge ${badgeClass}">${categoryLabel}</span>`;
|
| 1914 |
+
|
| 1915 |
+
card.innerHTML = `
|
| 1916 |
+
<div>
|
| 1917 |
+
<div class="lib-name">
|
| 1918 |
+
<span>${lib}</span>
|
| 1919 |
+
${roleBadge}
|
| 1920 |
+
</div>
|
| 1921 |
+
<div style="margin-top: 1rem;">
|
| 1922 |
+
<div class="lib-details-row">
|
| 1923 |
+
<span class="lib-details-label">Unique Compound IDs</span>
|
| 1924 |
+
<span class="lib-details-val">${details.unique_public_compound_ids.toLocaleString()}</span>
|
| 1925 |
+
</div>
|
| 1926 |
+
<div class="lib-details-row">
|
| 1927 |
+
<span class="lib-details-label">Unique SMILES Structure Maps</span>
|
| 1928 |
+
<span class="lib-details-val">${details.unique_smiles.toLocaleString()}</span>
|
| 1929 |
+
</div>
|
| 1930 |
+
<div class="lib-details-row">
|
| 1931 |
+
<span class="lib-details-label">Unique Names</span>
|
| 1932 |
+
<span class="lib-details-val">${details.unique_names.toLocaleString()}</span>
|
| 1933 |
+
</div>
|
| 1934 |
+
<div class="lib-details-row">
|
| 1935 |
+
<span class="lib-details-label">Total Profiled Nanowells</span>
|
| 1936 |
+
<span class="lib-details-val" style="color: #fff;">${sumCells.toLocaleString()}</span>
|
| 1937 |
+
</div>
|
| 1938 |
+
</div>
|
| 1939 |
+
</div>
|
| 1940 |
+
`;
|
| 1941 |
+
grid.appendChild(card);
|
| 1942 |
+
});
|
| 1943 |
+
}
|
| 1944 |
+
</script>
|
| 1945 |
+
</body>
|
| 1946 |
+
</html>
|