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README.md
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---
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language:
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- en
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license:
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- cc-by-4.0
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size_categories:
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- 1M<n<10M
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tags:
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- DNA Sequences
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- Protein Sequences
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- Computational Biology
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- Bioinformatics
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- Synthetic Biology
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task_categories:
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- token-classification
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---
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# CodonTransformer Dataset
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A comprehensive collection of DNA and protein sequence pairs from a diverse range of organisms, suitable for various computational biology and bioinformatics applications.
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## Dataset Summary
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The CodonTransformer dataset is a large-scale compilation of 1,001,197 DNA sequences and their corresponding protein translations, sourced from 164 different organisms across Eukaryotes, Bacteria, and Archaea. This dataset provides a rich resource for studying gene sequences, codon usage, and protein expression across diverse species.
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## Dataset Contents
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- 1,001,197 DNA-protein sequence pairs
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- Sequences from 164 organisms, including:
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- Eukaryotes: Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Danio rerio, Drosophila melanogaster, Mus musculus, Saccharomyces cerevisiae
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- Bacteria: Various Enterobacteriaceae species including Escherichia coli
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- Archaea: Thermococcus barophilus, Sulfolobus solfataricus
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- Chloroplast genomes: Chlamydomonas reinhardtii, Nicotiana tabacum
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## Data Collection and Preprocessing
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- **Source**: NCBI resources
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- **Original Format**: Gene or CDS (Coding Sequence)
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- **Protein Sequences**: Translated using NCBI Codon Tables
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- **Quality Control**:
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- DNA sequences divisible by three in length
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- Start with a start codon
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- End with a single stop codon
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## Dataset Structure
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Each entry contains:
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- DNA sequence
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- Corresponding protein sequence
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- Organism information
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## Uses and Applications
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This dataset is valuable for various research areas and applications, including:
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- Comparative genomics
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- Codon usage analysis
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- Protein expression optimization
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- Synthetic biology and genetic engineering
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- Machine learning models in bioinformatics
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It has been used to train the CodonTransformer model for codon optimization tasks.
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## Authors
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Adibvafa Fallahpour<sup>1,2</sup>\*, Vincent Gureghian<sup>3</sup>\*, Guillaume J. Filion<sup>2</sup>, Ariel B. Lindner<sup>3</sup>, Amir Pandi<sup>3</sup>‡
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<sup>1</sup> Vector Institute for Artificial Intelligence, Toronto ON, Canada
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<sup>2</sup> University of Toronto Scarborough; Department of Biological Science; Scarborough ON, Canada
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<sup>3</sup> Université Paris Cité, INSERM U1284, Center for Research and Interdisciplinarity, F-75006 Paris, France
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\* These authors contributed equally to this work.
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‡ To whom correspondence should be addressed: **amir.pandi@cri-paris.org** <br>
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## Additional Resources
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- **Project Website** <br>
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https://adibvafa.github.io/CodonTransformer/
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- **GitHub Repository** <br>
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https://github.com/Adibvafa/CodonTransformer
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- **Google Colab Demo** <br>
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https://adibvafa.github.io/CodonTransformer/GoogleColab
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- **PyPI Package** <br>
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https://pypi.org/project/CodonTransformer/
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- **Paper** <br>
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TBD
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