Update README.md

README.md

@@ -1,3 +1,29 @@
 ---
 license: cc-by-4.0
+tags:
+  - genomics
+  - proteomics
+  - alphamissense
+  - variant-pathogenicity
+size_categories:
+  - 10M<n<100M
 ---
+
+# AlphaMissense Cache for Allelix
+
+Pre-built SQLite cache of DeepMind's [AlphaMissense](https://github.com/google-deepmind/alphamissense) missense variant pathogenicity predictions, optimized for lookup by rsID.
+
+## Contents
+
+- `alphamissense.sqlite.gz` — gzipped SQLite database (~1.8 GB compressed, ~4 GB uncompressed)
+
+## Stats
+
+- 71,034,269 variant records
+- 7,543,463 with rsID mappings (via gnomAD coordinate join)
+- Composite primary key: `(chrom, pos, ref, alt)`
+- Indexed on `rsid`
+
+## Schema
+
+```sql