text stringlengths 117 334k | target stringlengths 20 2.97k | evaluation_predictions list |
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recently , magnetic thin films used in magnetic components , such as inductive devices and magnetic heads , have attracted more and more attention because of the increasing demand for improvement and miniaturization of electromagnetic devices [ 1 - 3 ] .
the basic requirements for these films operated in the ghz range ... | a series of nano - granular films composed of magnetic metal ( fe65co35 ) granules with a few nanometers in size and semiconductor oxide ( zno ) have been fabricated by a magnetron sputtering method , and excellent soft magnetic properties have been achieved in a wide metal volume fraction ( x ) range for as - deposit... | [
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juxtafacet cysts ( jfcs ) are uncommon intraspinal , extradural lesions that arise from the facet joints .
jfcs can be further distinguished as either synovial cysts , if histology confirms the presence of a synovial lining membrane , or alternatively as a ganglion cyst , if no such membrane is present .
however , few ... |
study design case report .
objective to report the case of one patient who developed a giant , completely calcified , juxtafacet cyst .
methods a 57-year - old woman presented with a 2-year history of progressively worsening lower back pain , left leg pain , weakness , and paresthesias .
imaging showed a ... | [
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panax ginseng ( ginseng ) has been used traditionally in eastern asia over thousands of years .
it has been used orally to treat various diseases including hypertension , diabetes mellitus , liver and kidney dysfunction , mental disorders , and postmenopausal disorders .
in addition , topical applications have also bee... | abnormal changes in skin color induce significant cosmetic problems and affect quality of life .
there are two groups of abnormal change in skin color ; hyperpigmentation and hypopigmentation .
hyperpigmentation , darkening skin color by excessive pigmentation , is a major concern for asian people with yellow bro... | [
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aneuploid strains were generated by sporulation of the above polyploid strains , followed by karyotype stability tests and determination as described in fig .
qpcr assays were designed with primers in non - coding regions on each chromosome arm ( supplementary table 1 lists primer sequences ) .
dna samples were prepare... | aneuploidy , referring here to genome contents characterized by abnormal numbers of chromosomes , has been associated with developmental defects , cancer , and adaptive evolution in experimental organisms19 .
however , it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly... | [
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the chemistry of metallocenes rapidly expanded in the 1970s with organozircocene emerging as one of the most useful classes of transition metal derivatives for use in organic synthesis .
one important reagent belonging to this class of organometallic compounds is the chlorobis(cyclopentadienyl)hydrido - zirconium ... | protection and deprotection strategies involving the n - acetyl group are widely utilized in nucleoside and nucleotide chemistry .
herein , we present a mild and selective n - deacetylation methodology , applicable to purine and pyrimidine nucleosides , by means of schwartz 's reagent , compatible with most of the c... | [
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in order to assess sexual well - being and provide treatment or education for iranian women 's sexuality , it is necessary to understand their sexuality and the meanings they give to sexual behaviors .
sexual behavior is a complex concept that is difficult to measure . according to webster 's online dictionary ,
the m... | the cultural compatibility of sexually related instruments is problematic because the contexts from which the concepts and meanings were extracted may be significantly different from related contexts in a different society .
this paper describes the instruments that have been used to assess sexual behaviors , primar... | [
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a level of pain that completely incapacitates one individual may cause only a minor annoyance in another .
characterizing the genetic factors affecting susceptibility to chronic pain could lead to novel treatment or prevention strategies , which are desperately needed . a recent paper by costigan et al .
the authors ... | a recent publication that combined rat gene expression data and a human genetic association study has identified the first genetic risk factor for chronic pain in humans . in four of
the five cohorts studied , there was a significant association of an allele within a gene ( kcns1 ) encoding a potassium channel ( kv9... | [
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optical coherence tomography ( oct ) is a noninvasive method that evaluates biological tissues by in vivo imaging.1 since its introduction , oct has undergone several improvements and revolutionized the diagnostic , monitoring , and therapeutic approaches to many retinal diseases and glaucoma .
computerized algorithms ... | purposewe aimed to evaluate the effect of cataract surgery on subfoveal choroidal thickness ( ct ) and ganglion cell complex ( gcc ) thickness , as measured by enhanced depth imaging - optical coherence tomography ( oct).methodsthis prospective study included 30 eyes of 30 patients who had undergone uneventful phacoem... | [
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only 2030% of patients with group a beta hemolytic streptococcus ( gabhs ) pharyngitis presents with classical symptoms of the disease .
reliance on clinical judgment alone has a poor predictive value and results in 80% to 95% overestimation of disease [ 2 , 3 ] .
diagnostic strategies for acute gabhs pharyngitis are t... |
background .
uncertainty exists concerning the necessity of 10-day antibiotic treatment of group a beta hemolytic streptococcus ( gabhs ) pharyngitis . objective . to assess the incidence of gabhs recurrence and suppurative and nonsuppurative complications in relation to compliance
. methods .
( design ) . pro... | [
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neurofibromatosis affects 1:3,000 individuals , and characterized by largely benign but often debilitating tumors that grow in the nervous system .
its course is unpredictable : it can cause a variety of benign nerve tumors including plexiform , dermal , and optic glioma tumors ; in some cases malignant peripheral nerv... | we report a patient with down 's syndrome and neurofibromatosis who presented with a keloid , sebaceous cyst and acanthosis nigricans , along with dental and ophthalmological defects .
the coexistence of neurofibromatosis type 1 and down 's syndrome which are two unrelated genetic conditions is itself a rarity . | [
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a 48-year - old man presented with acute lower extremity weakness and back pain developed while he was working in a crawl space hyper extending his back .
muscle strength was 4/5 in right iliopsoas and hamstrings , and 0/5 in the remaining muscles of right and all muscles of the left lower limb . bilateral knee and ank... | absent f wave in the stage of spinal shock has been described in cases of traumatic spinal cord injury .
the role of f wave in predicting prognosis after conus medullaris infarct has not been described .
we describe herein a middle aged - man with a conus medullaris infarct .
both tibial and peroneal f waves wer... | [
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west nile encephalitis is a mosquito - borne disease endemic to africa , asia , australia , and europe and the west nile virus is a single - stranded rna virus which belongs to the japanese encephalitis serogroup of flaviviruses ( 1 ) .
it could be accompanied with various neurologic symptoms and signs including headac... | west nile encephalitis was first identified in 1937 , but until now , it was never diagnosed in korea .
a 58-yr - old korean man was admitted with headache and cognitive dysfunction .
the patient had been on a business trip in guinea .
cerebrospinal fluid ( csf ) showed pleocytosis .
the patient complained of ... | [
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pathogens have evolved ingenious strategies to circumvent the host immune response as part of the constant evolutionary process - taking place in all living organisms .
chief among these strategies is the prevention of the inflammatory response or seizure of the anti - inflammatory mechanism in place to protect tissue ... | in the arms race of host microbe co - evolution , macrophages ( ms ) have been endowed with strategies to neutralize pathogenic challenge while preserving host integrity . during steady - states conditions ,
ms perform multiple house - keeping functions governed by their differentiation state , tissue distribution ... | [
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computational probe mapping is frequently
applied in structure - based
drug design ( sbdd ) to identify potential binding pockets along a protein
surface ( i.e. , hot spots ) . however , mapping is usually limited by the implementation
of gas - phase minimizations , wherein protein flexibility and solvent
com... | probe mapping is a common approach
for identifying potential binding
sites in structure - based drug design ; however , it typically relies
on energy minimizations of probes in the gas phase and a static protein
structure .
the mixed - solvent molecular dynamics ( mixmd ) approach was
recently developed to... | [
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the epstein barr virus ( ebv ) was described by michael anthony epstein and yvonne barr , who isolated ebv virus particles from endemic burkitt lymphoma specimens .
ebv is a double stranded dna virus of the herpes virus family and is the most common virus affecting humans .
the infection occurs through oral transmissi... | lymphoproliferations associated with epstein barr virus ( ebv ) in adult patients pose a diagnostic challenge for pathologists for several reasons .
first , the ebv lymphoproliferations represent a clinically and histologically very broad spectrum ranging from self - limiting lymphoproliferations to manifest malign... | [
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hepatitis c virus ( hcv ) is a global healthcare problem , with a prevalence of around 3% worldwide ( 1 ) ; it has six major genotypes ( types 1 6 ) .
most infected patients will establish chronicity with long - term complications , including liver fibrosis , cirrhosis , and hepatocellular carcinoma ( hcc ) ( 2 ) .
th... | backgroundmicrornas ( mirnas ) have been repeatedly shown to play important roles in liver pathologies , including hepatitis , liver cirrhosis , and liver cancer .
egypt has the highest hepatitis c virus ( hcv ) infection rate worldwide , predominantly involving genotype-4.objectivesin this study , we attempted to c... | [
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epidermoid cysts are benign developmental malformations arising from abnormal epithelial constituents of ectodermal tissue formed during the fetal period .
these lesions can be seen anywhere in the body , with the occurrence of approximately 7% in the head and neck region and their incidence in the oral cavity makes up... | epidermoid cysts are benign malformations that can be encountered anywhere in the body and are rarely observed in the oral cavity accounting for < 0.01% of all cysts of the oral cavity .
they can be classified as either congenital or acquired without any clinical or histologic differences .
our literature search d... | [
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thirty years have passed after discovering human immunodeficiency virus ( hiv ) , the etiological agent of the acquired immunodeficiency syndrome ( aids ) [ 14 ] .
two types of hiv are known : the most common hiv-1 , which is responsible to the worldwide aids epidemic , and the immunologically distinct hiv-2 , which is... | despite advances in antiretroviral therapy that have revolutionized hiv disease management , effective control of the hiv infection pandemic remains elusive . beyond the classic non - b endemic areas ,
hiv-1 non - b subtype infections are sharply increasing in previous subtype b homogeneous areas such as europe and ... | [
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every year more than 14 million cases of obstetric hemorrhage occur , resulting in an estimated 127,000 deaths.1 postpartum hemorrhage ( pph ) , blood loss of 500 ml or more , accounts for the majority of these hemorrhage deaths.2 pph is the leading cause of maternal death in low income countries and is the primary cau... | backgroundpostpartum hemorrhage ( pph ) is the leading cause of maternal death in low - income countries and is the primary cause of approximately one - quarter of global maternal deaths .
the purpose of this paper is to provide a review of pph prevention interventions , with a particular focus on misoprostol , and ... | [
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the first n - terminal acetylation is catalyzed a variety of n - terminal acetyltransferases ( nats ) , which co - translationally transfer acetyl moieties from acetyl - coenzyme a ( acetyl - coa ) to the -amino
although n - terminal acetylation is rare in prokaryotes , it was estimated that 85% of eukaryotic proteins ... | as a reversible post - translational modification ( ptm ) discovered decades ago , protein lysine acetylation was known for its regulation of transcription through the modification of histones .
recent studies discovered that lysine acetylation targets broad substrates and especially plays an essential role in cellu... | [
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advances in medical care and neonatal medicine have led to changes in survival pattern of high risk neonates ( 1 ) .
one of the complications that have been found in these high risk neonates is lbw ( < 2500 grams ) . according to world health organization ( who ) statistics , the rate of lbw is 17% worldwide ( 6% in ... |
background : to determine whether using mechanical ventilation in neonatal intensive care unit
( nicu ) influences motor development of low birth weight ( lbw ) infants and to compare their motor
development with normal birth weight ( nbw ) infants at the age of 8 to 12 months using peabody
developmental motor... | [
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the alpha omega trial is a multicenter , double - blind , placebo - controlled trial with a 2 2 factorial design , which has been described in detail elsewhere ( 6,7 ) . in collaboration with cardiologists from 32 hospitals in the netherlands
, we recruited 4,837 patients aged 6080 years with a clinically diagnosed mi... | objectivewe carried out a secondary analysis in high - risk patients with a previous myocardial infarction ( mi ) and diabetes in the alpha omega trial .
we tested the hypothesis that in these patients an increased intake of the n-3 fatty acids eicosapentaenoic acid ( epa ) , docosahexaenoic acid ( dha ) , and -lino... | [
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for more than 40 years , metal ceramic restorations ( mcrs ) have been widely used in the fabrication of fixed partial dentures ( fpds ) and still represent the gold standard nowadays.1 the success of these mcrs depends on the effective bonding between the veneering ceramic and metal substructure , which is believed to... | purposepre - surface treatments of coping materials have been recommended to enhance the bonding to the veneering ceramic .
little is known on the effect on shear bond strength , particularly with new coping material .
the aim of this study was to investigate the shear bond strength of veneering ceramic to three c... | [
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the ministry of health , labour and welfare
of japan has recommended shortening of the length of hospital stays1 . in general , shortening the length of stay contributes to a
reduction in the physical and mental stress of patients and rapidly returns them to their
jobs and communities .
actually , in a previous s... | [ purpose ] the aim of this study was to describe the importance of patient - related factors
in rehabilitation .
we focused on the type a behavior pattern .
if individuals with the type
a behavior pattern have better compliance , they would have a shorter length of hospital
stay than those with non - type a... | [
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its effect is mediated via interactions with several receptors in the central nervous system and results from a combination of antidopaminergic , anticholinergic , antihistaminic , and weak antiadrenergic actions .
the therapeutic effects of chlorpromazine are frequently accompanied by unwanted side effects that includ... | chlorpromazine is a well - known antipsychotic agent that binds with a variety of receptors in the central nervous system . to date
, chlorpromazine has never been associated with onset of hearing disorders and tinnitus .
we report on an unexpected suspect adverse reaction to chlorpromazine that occurred in a 12-y... | [
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9937,
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34... |
investigating
factors that influence the stability of the secondary
structure of peptides and proteins , such as confinement , competitive
solvation in a heterogeneous environment , and peptide functional group
modifications , is important to our understanding of why proteins misfold
and aggregate .
reverse m... | the propensity of peptides to form
-helices has been intensely
studied using theory , computation , and experiment .
important model
peptides for the study of the coil - to - helix transition have been alanine
lysine
( aka ) peptides in which the lysine residues are placed on opposite
sides of the helix... | [
2,
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one of them is that development is the increase in production , promoting the health and therapeutic services level , and eliminating problems .
therefore , development as it is considered by people and national institutions is a complicated and multidimensional process that requires changes in social structure , accel... |
background : one of the main indexes of development is health index or the degree to which a
society enjoys health and therapeutic services . the present study was done with the aim to analyze
development levels in cities in tehran regarding health infrastructural index using the standardized
score and morris ... | [
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... |
hepatolithiasis , that is , the formation of stones in the intrahepatic biliary tree , is most prevalent in east asia , including china , japan , and korea ( 1 ) .
the goals of primary treatment are to resolve ongoing infections and to prevent recurrent cholangitis , subsequent hepatic fibrosis , and progression to cho... | hepatobiliary complications , such as stone recurrence , recurrent cholangitis , liver abscess , secondary biliary cirrhosis , and cholangiocarcinoma may occur after treatment for hepatolithiasis . however , few previous studies have addressed the risk factors and long - term outcomes after initial treatment .
eight... | [
2,
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... |
tuberculosis of oral cavity is a rare entity . even before antitubercular chemotherapy era , oral lesions occurred less commonly in patients with pulmonary tuberculosis .
a 55-year - old labourer was referred to the outpatient department of our centre as a case of suspected gingivobu - ccal carcinoma for further evalua... | tuberculosis of the oral cavity is a rare condition .
a 55-year - old labourer was referred as a case of oral cancer for further management .
the patient had no systemic symptoms .
biopsy of the lesion revealed caseating granulomatous inflammation .
chest x - ray and sputum revealed evidence of asymptomatic pu... | [
2,
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12... |
a sandwich or laminate technique is one of the methods proposed for composite resin restorations , which was introduced for the first time by mclean , et al . in 1985 . the basic idea behind this technique is to use two different restorative materials for a single restorative procedure so that the maximum physico - mec... | background : an appropriate bond between glass - ionomer and the superficial resin materials is very important for the success of sandwich technique . the aim of the present in vitro study was to evaluate the effect of three surface treatments of conventional glass - ionomer on its shear bond strength to giomer.materi... | [
2,
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5404,
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... |
it is well known that the stress transfer between an implant device and a bone is not homogeneous when young 's moduli of the implant device and the bone are different ; this is defined as stress shielding . in such conditions ,
bone atrophy occurs and leads to the loosening of the implant and refracturing of the... |
-type titanium alloys with low young 's modulus are required to inhibit bone atrophy and enhance bone remodeling for implants used to substitute failed hard tissue . at the same time
, these titanium alloys are required to have high static and dynamic strength . on the other hand ,
metallic biomaterials with var... | [
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cervical spondylosis is a common cause of chronic neck pain , radiculopathy and/or myelopathy resulting in significant disability .
when patients do not respond to conservative therapy , anterior cervical discectomy and fusion ( acdf ) usually is used to achieve neural decompression , maintain cervical lordosis , and p... | abstractcervical spondylosis and hypertension are all common diseases , but the relationship between them has never been studied .
patients with cervical spondylosis are often accompanied with vertigo .
anterior cervical discectomy and fusion is an effective method of treatment for cervical spondylosis with cervic... | [
2,
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... |
the worldwide incidence of strabismus varies from 3% to 5%,1,2 whereas hu and colleagues3 identified strabismus in 2% to 4% of white populations , and abrahamsson and colleagues4 reported strabismus in 0.6% of asians3 and africans.5 in a study conducted by dana and colleagues5 in sydney , the incidence of strabismus wa... | background and objectivesquint surgery is frequently performed successfully in hyderabad .
however , no study in any detail has been performed on the outcome of monocular surgery for horizontal squint in the region .
this study aims to determine the results of monocular surgery for horizontal trabismus.designretro... | [
2,
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15... |
sepsis is the systemic inflammation caused by infection with bacteria , viruses , fungi , parasites , or toxic products , and has become one of the leading causes of mortality in children . in developed countries ,
the mortality rate of pediatric sepsis is about 210% and is as high as 50% in developing countries .
pedi... | backgroundpediatric sepsis has high morbidity in children , may lead to acute kidney injury ( aki ) , and further aggravate the disease .
baicalin is a kind of flavonoid in scutellaria baicalensis georgi and has been reported to protect against several diseases , but its roles in septic aki remain unclear .
this s... | [
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fucosidosis is a rare lysosomal storage disorder , which is inherited in autosomal recessive pattern due to deficient activity of the enzyme alpha l fucosidase .
type i presents in infancy with a very rapid progression of illness and death in early childhood , whereas type ii presents later with lesser severity althoug... | fucosidosis is a rare lysosomal storage disorder due to deficiency of fucosidase enzyme , with around 100 cases reported worldwide . here , we describe the clinical and imaging features in two siblings with fucosidosis . an 8-year - old girl presented with global developmental delay , followed by regression of acquire... | [
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in order to collect a set of images useful to test the algorithm , we run 10 plasma samples using 2d - ge . 2d - ge was performed according to maresca et al .
, with each sample run in duplicate . for the first - dimension of electrophoresis ,
200 g of plasma protein samples ( approximately 3 l ) were applied to 18-c... | analysis of images obtained from two - dimensional gel electrophoresis ( 2d - ge ) is a topic of utmost importance in bioinformatics research , since commercial and academic software available currently has proven to be neither completely effective nor fully automatic , often requiring manual revision and refinement o... | [
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... |
pulmonary arterial hypertension ( pah ) is a devastating disease with 50% mortality at 2.8 years in patients left untreated or unresponsive to treatment.1 diagnostic evaluation in patients with pulmonary hypertension ( ph ) includes an echocardiogram , which when performed as it routinely undertaken even in tertiary re... | background : one of the commonest causes of pulmonary hypertension ( ph ) is left heart dysfunction associated with elevated pulmonary capillary wedge pressure ( pcwp ) .
in contrast , the pathology of pulmonary arterial hypertension ( pah ) originates in the pulmonary vascular bed .
accurate diagnosis of pah requ... | [
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115,
1044,
... |
dual antiplatelet therapy consisting of aspirin and an adenine diphosphate ( adp ) p2y12 receptor antagonist is recommended as the standard antiplatelet regimen for patients with coronary artery disease.1 clopidogrel , an adp p2y12 receptor antagonist , strongly inhibits formation of thrombosis by impeding platelet bin... | backgroundsimultaneous prescription of clopidogrel and low - dose aspirin is recommended for the treatment of acute coronary syndrome because of improvements in efficacy and patient compliance . in this study ,
the pharmacokinetics of a fixed - dose combination ( fdc ) of clopidogrel and aspirin was compared with co... | [
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5734,
1852,
... |
fulvestrant ( faslodex ; astrazeneca ) is a novel steroidal estrogen receptor ( er ) antagonist lacking agonist effects . by covalent binding to the er , receptors are rapidly downregulated , resulting in a decrease of cellular er levels and complete abrogation of estrogen - sensitive gene transcription .
the efficacy ... | we report a case of long - term ( 9 years ) response to 4th - line endocrine treatment with fulvestrant given for advanced breast cancer after no or poor response to prior endocrine therapies .
complete remission was achieved with full dose and maintained even after dose reduction due to unanticipated intensity of m... | [
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68362,
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18822,
143,
110,
4717,
... |
infestation with the liver flukes fasciola hepatica and fasciola gigantica , has traditionally been associated with substantial production and economic losses in livestock , particularly sheep and cattle ( 1 ) .
several studies have shown that f. hepatica occurs in temperate areas , while f. gigantica occurs mainly in ... | background : fasciola hepatica and f. gigantica are the causative agents of fasciolosis in domestic animals and humans . based on the morphometric criteria , differential diagnosis between them is problematic .
in addition , intermediate forms of fasciola have been found in iran , which makes the differentiation mor... | [
2,
109,
2560,
113,
136,
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117,
112,
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28071,
6761,
4357,
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91779,
7078,
30105,
303,
3178,
29810,
87859,
53119,
... |
the recent development of whole slide imaging ( wsi ) is rapidly making many advances in pathology and enabling the creation of novel tools and applications for the pathology community , including virtual microscopy , and computer - aided quantification and diagnosis .
in contrast to conventional light microscopy that ... | background : whole slide imaging ( wsi ) offers a novel approach to digitize and review pathology slides , but the voluminous data generated by this technology demand new computational methods for image analysis.materials and methods : in this study , we report a method that recognizes stains in wsi data and uses kern... | [
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3033,
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106,
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195... |
survival rates continue to improve with the advent of more refined treatments and better supportive care .
today over 80% of children with cancer are alive for at least five years , and the majority of these are cured . as a consequence , many sufferers of childhood cancer are now living into adulthood and having famil... | we determined the extent and distribution of cancers in relatives of 379 children newly diagnosed with cancer .
family history was collected from 1,337 first - degree and 3,399 second - degree relatives and incidence compared with national age- and gender - specific rates .
overall , 14 children ( 3.7% ) had a rel... | [
2,
145,
731,
124,
114,
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113,
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231,
113,
779,
110,
158,
122,
... |
this special issue of fungal genetics and biology describes a comprehensive effort to develop methods and expertise to tackle one of the world s most serious fungal diseases of wheat .
the series of papers within this issue are designed to provide a resource for a new generation of plant pathologists who we hope will b... | septoria blotch of wheat is one of the world s most serious plant diseases , which is difficult to control due to the absence of durable host resistance and the increasing frequency of fungicide - resistance . the ascomycete fungus that causes the disease , zymoseptoria tritici , has been very challenging to study
.... | [
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7698,
889,
111,
4272,
110,
108... |
endometrial carcinoma is the most common gynecologic malignancy , with an estimated 40 100 incident cases and 7470 deaths in 2009 .
the current standard of care for patients with endometrial cancer consists of surgical staging , including total hysterectomy , bilateral salpingo - oophorectomy , and pelvic and para - ao... | purposewe sought to evaluate pathological response , tolerance , and outcome after preoperative ( neoadjuvant ) high dose rate brachytherapy in a small series of patients with clinical stage ii endometrial carcinoma , and to evaluate a dose and fractionation protocol for this treatment.material and methodstwelve women... | [
2,
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1396,
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151,
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971,
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21997,
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51286,
110,
107,
118,
5029,
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1044,
110,
108,
... |
the availability or utilization of health services does not always guarantee better health outcomes and it requires safe delivery of quality health services .
unsafe care is a global challenge , which often leads to adverse events and poor treatment outcomes .
the limited data from low- and middle - income countries re... | background : there is insufficient information on causes of unsafe care at facility levels in india .
this study was conducted to understand the challenges in government hospitals in ensuring patient safety and to propose solutions to improve patient care.materials and methods : desk review , in - depth interviews ,... | [
2,
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3047,
115,
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3370,
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2771,
130,
15646,
473,
... |
5xfad tg mouse model ( b6sjl - tg(appswfllon , psen1*m146l*l286v)6799vas ) ( jackson laboratories ) is bred on a non - transgenic background ( b6sjlf1 ) .
hela is a human cervical cancer cell line ; nih/3t3s is a mouse embryonic fibroblast line ; hepg3 is from hepatocellular carcinoma ; raw264.7 is a mouse leukemic mon... | one way to image the molecular pathology in alzheimer s disease ( ad ) is by positron emission tomography using probes that target amyloid fibrils .
however , these fibrils are not closely linked to the development of the disease .
it is now thought that early stage biomarkers that instigate memory loss comprise o... | [
2,
79744,
39578,
143,
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1695,
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540,
110... |
retinoblastoma is the most common intraocular malignancy in childhood , and represents about 3% of all pediatric disease .
retinoblastoma , a diagnosis that affects not only vision but also survival for many individuals , is also the most common intraocular tumor of childhood .
the incidence of retinoblastoma is genera... | backgroundin our clinical experience we discovered that eeg band power may be correlated with corneal nerve injury in retinoblastoma patients .
this study aimed to investigate biomarkers obtained from electroencephalography ( eeg ) recordings to reflect corneal nerve injury in retinoblastoma patients.material/method... | [
2,
145,
10920,
109,
1289,
317,
48023,
8165,
2015,
111,
109,
5220,
113,
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174,
3795,
112,
109,
2... |
disrupted in schizophrenia 1 ( disc1 ) was initially discovered at the breakpoint in a balanced chromosomal translocation t ( 1 ; 11 ) segregating with major mental conditions , such as schizophrenia , bipolar disorder , and major depression in a scottish pedigree ( millar et al . , 2000 ) . since then , accumulating e... | genetic risk factors for major psychiatric disorders play key roles in neurodevelopment .
thus , exploring the molecular pathways of risk genes is important not only for understanding the molecular mechanisms underlying brain development , but also to decipher how genetic disturbances affect brain maturation and fun... | [
2,
24268,
28603,
305,
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110,
108,
111,
1... |
the erythrocyte sedimentation rate ( esr ) is an acute phase reactant ( apr ) .
the rate of sedimentation in a period of one hour called esr and also biernacki test .
esr test is a common hematologic nonspecific indicator of inflammation . to perform a test , nonclothing blood
is placed in a vertical tube ( westergren ... |
background . erythrocyte sedimentation rate ( esr ) is a valuable laboratory tool in evaluation of infectious , inflammatory , and malignant diseases .
red blood cells in outside from the body precipitate due to their higher density than the plasma . in this study
we discuss the ivig effect on esr in different d... | [
2,
109,
110,
8723,
307,
551,
63589,
80020,
872,
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1108,
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833,
... |
indications for covered self - expandable metallic airway stent removal include recurrent mucous plugging of the stent , excessive or recurrent granuloma formation , migration of the stent , stent infection , recurrence of stenosis , stent failure , stent fractures and accomplishment of treatment . usually , it is tedi... | covered self expandable metallic airway stents ( sems ) have been used for benign tracheal stenosis , post intubation tracheal stenosis , tracheal burn or trauma , tracheo - broncho - malacia , and extrinsic compression of trachea .
their placement is considered to be permanent , with open surgery the only way to re... | [
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114,
620,
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113,
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113,
114,
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metastatic lesions comprise approximately 1% of the tumors in the sellar / parasellar ( sps ) area for which patients undergo transsphenoidal surgery ( tss ) [ 1 , 2 ] ; however , it has been reported in autopsy series that the rate of metastasis to these areas could be as high as 28% .
breast and lung cancer are the t... | the sellar and parasellar ( sps ) region is a complex area rich in vital neurovascular structures and as such may be the location of first manifestation of a systemic malignancy .
metastases to this region are rare ; breast cancer is the most common source among those that metastasize to the sps region .
ophthalmo... | [
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when a septal deviation ( sd ) is present during the endoscopy performed before a transcanalicular diode laser - assisted dacryocystorhinostomy ( tcl dcr ) , one tends to think that this anatomical alteration could influence the final result , due to technical difficulties and alterations in osteotomy healing .
dacryoc... |
purpose .
the objective of the present study is to determine whether the success rate in transcanalicular diode laser - assisted dacryocystorhinostomy ( tcl dcr ) is influenced by the variant septal deviation ( sd )
. methods .
patients were divided into two groups : one including operated lacrimal pathways ( ... | [
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when do such problems become abnormal and merit a specific psychiatric diagnostic label , remains a question under study with no clear cut answers .
we present a case of a young girl for whom clinical attention was sought for transient eating problems .
a 12-year - old young lady belonging to lower socioeconomic rural ... | eating problems are commonly encountered in childhood and adolescents , and may be manifestation of a variety of psychiatric disorders when medical causes are excluded .
we present the case of a young lady presenting with problems of eating which presented with difficulties of ascribing a diagnostic label for eating... | [
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adenoid cystic carcinoma ( adcc ) is a malignant salivary gland tumor that was first described by billroth in 1859 under the name cylindroma attributing to its cribriform appearance formed by the tumor cells with cylindrical pseudolumina or pseudospaces .
the term adenoid cystic carcinoma was introduced by ewing ( fo... | adenoid cystic carcinoma is an uncommon , slow growing malignant salivary gland tumor that is characterized by wide local infiltration , perineural spread , propensity to local recurrence and distant metastasis . in this paper , the authors present a case of adenoid cystic carcinoma affecting the palate and involving ... | [
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interacting with other human beings is a basic element of daily life , yet not a trivial challenge .
many joint actions between adults are highly sophisticated , but are performed with apparent ease ( knoblich and jordan 2003 ; sebanz et al .
2006 ) . cooking a meal with friends , lifting a heavy bag together , or danc... | when we are engaged in a joint action , we need to integrate our partner s actions with our own actions .
previous research has shown that in adults the involvement of one s own motor system is enhanced during observation of an action partner as compared to during observation of an individual actor .
the aim of th... | [
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we have demonstrated that , melatonin is a bioprecursor of hypnotic acetyl metabolites produced by enzymatic acetylation of melatonin and 2-oxomelatonin under the control of acetyltransferases , most probably the nat enzymes . in 1994 , in our laboratory , we developed a specific and highly sensitive gas chromatography... | pharmacokinetic studies of melatonin in young and elderly human volunteers , and the measurement of hypnotic effects in chicks under alternate light - dark or permanent light conditions , show that melatonin is a bioprecursor of hypnotic acetyl metabolites produced by the enzymatic acetylation of both melatonin and 2-... | [
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previously we reported that deletion of neutral endopeptidase ( nep ) provides protection from obesity- and diabetes - induced neural complications .
we have also shown that treating obese and streptozotocin - diabetic mice with the vasopeptidase inhibitor ilepatril prevented neural complications including slowing of n... | we have demonstrated that treating diet - induced obese ( dio ) mice with the vasopeptidase inhibitor ilepatril improved neural function .
vasopeptidase inhibitors block angiotensin - converting enzyme ( ace ) and neutral endopeptidase ( nep ) activity .
we propose that increased activity of ace and nep contribute... | [
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... |
rickettsia are obligatory , intracellular , small gram - negative bacteria associated with eukaryotic hosts .
they are traditionally divided into three groups : the spotted fever group , the typhus group and the scrub typhus group .
the spotted fever results from a large group of tick- , mite- and flea - borne zoonotic... | rickettsial diseases are common in srilanka .
the spotted fever group of rickettsiae presents in many ways , including very severe disease causing significant morbidity and mortality . a regional variation of the rickettsia conorii subspecies and differences in clinical presentations
are reported .
this case des... | [
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76461,
697... |
despite many years of research efforts and impressive progress in knowledge of mechanisms of endometriosis development , the etiopathogenesis of the disease and exact cause of infertility in patients suffering from endometriosis still remain poorly understood .
none of the theories and models of endometriosis pathogene... | the etiopathogenesis of endometriosis still remains unknown .
recent data provide new valuable information concerning the role of oxidative stress in the pathophysiology of the disease .
it has been proved that levels of different lipid peroxidation end products are increased in both peritoneal fluid ( pf ) and se... | [
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201,
145,
374,
283... |
posttraumatic stress disorder ( ptsd ) is a complex mental disorder that can develop in response
to a traumatic event such as a motor vehicle accident , rape , combat exposure or natural
disaster .
the national vietnam veterans readjustment study estimated that 53.4% of us male
veterans of the vietnam... | posttraumatic stress disorder ( ptsd ) is associated with decreased activity in the
dorsolateral prefrontal cortex ( dlpfc ) , the brain region that regulates working memory and
preparation and selection of fear responses .
we investigated gene expression profiles in dlpfc
brodmann area ( ba ) 4... | [
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there is increasing evidence that higher levels of high sensitivity c - reactive protein ( hs - crp ) is a marker of inflammation and a potential independent predictor of cardiovascular disease , as it may play a role in the development of atherosclerosis , adversely affecting mortality.1)2 ) rate of obesity is increas... | background and objectivesserum high sensitivity c - reactive protein ( hs - crp ) is a marker of inflammation and may lead to the development of atherosclerosis , adversely affecting mortality .
the aim of this study was to evaluate the relationship between baseline hs - crp level and 12-month clinical outcomes in p... | [
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... |
macrolide , lincosamide and streptogramin b ( mlsb ) antibiotics are structurally different with a same mechanism of action .
these drugs , especially clindamycin , are alternative drugs for some staphylococcus aureus infections such as skin and soft tissue infections particularly in penicillin - allergic patients ( 1 ... | background : clindamycin is a frequently used antimicrobial therapeutic medicine used for the treatment of skin and soft tissue infections caused by staphylococcus aureus strains . resistance to this antibiotic is either constitutive or inducible .
constitutive resistance to clindamycin could be detected by standard... | [
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2363,
23... |
the lingual tonsils develop at 6.5 weeks between the second and third arches ventrally while palatine tonsils develop at 8 weeks from second pouch ( ventral and dorsal ) .
tonsils are predominantly b - organs and b - lymphocytes comprise 5060% of tonsillar lymphocytes .
ample evidence shows that tonsils are involved in... |
objectives . tonsillitis is a common infection in all age groups , especially under the age of five . organisms causing this condition vary from place to place .
our aim is to find out the main causative agents of this condition in our hospital .
patients and methods .
fifty - two consenting patients who neede... | [
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the basic goal of therapy is to achieve a steady state blood level that is therapeutically effective and nontoxic for an extended period of time .
the design of proper dosage regimens is an important element in accomplishing this goal . in conventional oral dosage forms drug dosage
this drawback of conventional dosage ... | aim and background : the novelty of the present study was to control the release profile of matrix tablets of losartan potassium prepared by using different concentrations of chitosan and trisodium citrate as cross - linking agent with combination of various release retardant polymers.materials and methods : twelve fo... | [
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adenomyosis is a common gynecological condition that is characterized by ingrowths of the endometrial cells into the myometrium .
adenomyosis and leiomyoma are benign conditions that are often responsible for uterine enlargement , menorrhagia , anemia , and infertility .
adenomyosis or internal endometriosis may occur ... | objective : to evaluate the accuracy , sensitivity , specificity , positive predictive value ( ppv ) , and negative predictive value ( npv ) of the diagnosis of adenomyosis , leiomyoma , or combined adenomyosis and leiomyoma by the use of transvaginal ultrasonography ( tvs ) compared to the histopathological findings.... | [
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107... |
peptide amphiphiles are a fascinating
class of bioactive molecules
in which one or more lipid chains are attached to peptides , either
bioderived , bioinspired , or designed .
the lipid chains drive self - assembly ,
leading to nanostructures in which the functional peptide unit can
be presented at high densi... | the enzymatic cleavage
of a peptide amphiphile ( pa ) is investigated .
the self - assembly of the cleaved products is distinct from that of
the pa substrate .
the pa c16-kkffvlk is cleaved by -chymotrypsin
at two sites leading to products c16-kkf with fvlk and
c16-kkff with vlk .
the pa c16-kkffvlk fo... | [
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participants were autoantibody - positive relatives of t1d patients from the dpt-1 ( n = 670 ) and tnnhs ( n = 991 ) cohorts .
dpt-1 participants were all islet cell autoantibody ( ica ) positive , whereas tnnhs participants were all positive for gada , ia-2a , miaa , and/or ica .
both studies were approved by institut... | objectivewe studied the utility of the diabetes prevention trial - type 1 risk score ( dptrs ) for improving the accuracy of type 1 diabetes ( t1d ) risk classification in trialnet natural history study ( tnnhs ) participants.research design and methodsthe cumulative incidence of t1d was compared between normoglycemic... | [
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tumors derive from a single cell clone but consist of heterogeneous cell subpopulations with diverse features and functions .
sequencing analysis has revealed that tumors accumulate mutations , the majority of which do not provide selective benefits , while a small subset of mutations drive cancer development by confer... | tumors derive from a single cell clone but consist of heterogeneous cell subpopulations with diverse features and functions . a limited number of subclones with a selective advantage can initiate tumors when inoculated into immunocompromised mice , and are called cancer - initiating cells ( cics ) .
cics can be is... | [
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some forms , such as declarative memory , are explicit memories of objects , places , or events .
others forms , such as non - declarative memory , are implicit , like habits , skills , or priming , and do not require conscious awareness ( gilbert et al .
, 2001 ; squire , 2004 ) . while this has been an established ta... | classical ( trace ) conditioning is a specific variant of associative learning in which a neutral stimulus leads to the subsequent prediction of an emotionally charged or noxious stimulus after a temporal gap .
when conditioning is concurrent with a distraction task , only participants who can report the relationshi... | [
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world health organization estimates that one million serious unintentional poisonings occur every year and an additional two million people are hospitalized for suicide attempts with pesticides .
india is a predominantly agrarian country where pesticides are routinely used for farming . according to data available from... | background : organophosphorus ( op ) poisoning is a major health problem all over the world , particularly in the developing countries.aim:the present study aims to explore the clinical and epidemiological features found in patients presenting with op poisoning.materials and methods : a 1-year cross - sectional study ... | [
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... |
village indigenous birds are constantly exposed to immunosuppressive conditions such as aflatoxicosis and infectious bursal disease virus .
in addition , management and ecological factors such as confinement , climatic and seasonal fluctuations , poor feeding , and worm infestations have been associated with stress and... | this study was carried out to verify the possibility that ducks are sources of newcastle disease ( nd ) virus infection for chickens in mixed flocks .
immunosuppressed ( is ) and non immunosuppressed ( nis ) birds , at three different antibody levels ( medium , low and absent ) were used ; the titres having been ind... | [
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... |
rheumatoid arthritis ( ra ) is a chronic systemic inflammatory disease affecting predominantly joints , synovial membranes , articular cartilages , and subchondral bones .
disease progression is attributed to increases in reactive oxygen species ( ros ) and oxidative stress ( os ) in the lesion sites .
proinflammatory ... | rheumatoid arthritis ( ra ) is a chronic inflammatory disease , leading to progressive destruction of joints and extra - articular tissues , including organs such as liver and spleen .
the purpose of this study was to compare the effects of a potential immunomodulator , natural polyphenol n - feruloylserotonin ( n -... | [
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a recent institute of medicine ( iom ) report on this subject acknowledges that the rates and impact of medication errors are huge but are poorly understood .
the president of the institute of safe medication practices ( ismp ) , michael cohen , in his testimony to a committee of the us congress estimated that the doll... |
background .
most safety issues in primary care arise from adverse drug events .
team resource management intervention was developed to identify systemic safety issues to design and implement interventions to address prioritized issues .
objectives .
evaluate impact of intervention on rates of events and p... | [
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2108,
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127,
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2478,
603,
143,
20054,
208,
110,
158,
8... |
in 2007 , the world health organization ( who ) launched its initiative for the global elimination of congenital syphilis , with the goal that by 2015 at least 90% of pregnant women are tested for syphilis and at least 90% of seropositive pregnant women receive adequate treatment . subsequently in september 2010 , paho... |
objective . to describe the current epidemiological features of syphilis and congenital
syphilis in trinidad , 20092012 . methods . all laboratory confirmed syphilis cases diagnosed through a vertical
program in the ministry of health , between 1/1/2009 and 31/12/2012 , were identified .
all relevant data were... | [
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they say passing a kidney stone is the worst pain you could ever have .
i still feel it now , intense as ever , 10 years later .
dan vento is talking about the time his daughter suffered a relapse of an uncommon form of cancer called osteosarcoma .
but a year later , jennifer s left knee began to swell and hurt agai... | medicine regards pain as a signal of physical injury to the body despite evidence contradicting the linkage and despite the exclusion of vast numbers of sufferers who experience psychological pain . by broadening our concept of pain and making it more inclusive
, we would not only better accommodate the basic scienc... | [
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111,
199,
126,
38985,
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214,
110,
107,
106,
145,
171,
110,
58... |
in 2014 , it is estimated that there are 608,620 bladder cancer survivors living in the united states , and an additional 74,690 cases will be diagnosed .
neoadjuvant chemotherapy ( nc ) followed by radical cystectomy ( rc ) is now considered the standard of care for muscle - invasive bladder cancer after numerous tria... |
objective . to report our contemporary experience with partial cystectomy after neoadjuvant chemotherapy .
patients and methods . retrospective review of patients who underwent neoadjuvant chemotherapy and partial cystectomy for urothelial cell carcinoma of the bladder at memorial sloan kettering cancer center fro... | [
2,
145,
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4703,
110,
107,
113,
109,
1790,
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5337,
110,
8932,
3142,
115,
136,
... |
selective serotonin reuptake inhibitors ( ssris ) , serotonin and norepinephrine reuptake inhibitors , and noradrenergic and specific serotonergic antidepressants are categorized as first - line treatments in many countries , including japan.1,2 thus , health care providers have the opportunity to choose an antidepress... | backgroundapproved doses of antidepressants in japan are usually lower than those in the usa and european union , but to date meta - analyses comparing antidepressants have all used the higher doses approved in the usa and european union and often have used indirect comparisons .
the purpose of this study was to con... | [
2,
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115,
41862,
110,
107,
... |
the prevalence rate in the general population ranges between 10% and 12% , making this disease one of the most common causes of pain , activity limitation , and restrictions in participation .
knee osteoarthritis ( gonarthrosis ) is one of the most frequent forms of degenerative osteoarthritis . in knee osteoarthritis
... | abstractbackground : pes anserine bursitis strongly affects quality of life in patients with osteoarthritis .
treatment includes nonsteroidal anti - inflammatory drugs ( nsaids ) , physiotherapy , and injections of corticosteroid , with highly variable responses ; recovery can take 10 days to 36 months .
mesothera... | [
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10... |
neurological soft signs ( nss ) have long been considered one of the functional features ( tsuang and faraone , 1999 ; tsuang et al . , 1991 ) and endophenotypes ( chan and gottesman , 2008 ; chan et al . , 2010a ) of schizophrenia spectrum disorders .
however , most of the studies of nss have been limited to the use o... | neurological soft signs have been considered one of the promising neurological endophenotypes for schizophrenia . however ,
most previous studies have employed clinical rating data only . the present study aimed to examine the neurobiological basis of one of the typical motor coordination signs , the fist edge
p... | [
2,
19561,
1607,
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116,
116,
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colonic necrosis has been described as a rare complication after the administration of kayexalate [ 1 , 2 ] . in this case study , we present a case of calcium polystyrene sulfonate - induced colonic necrosis and perforation to remind clinicians of this rare , but dangerous , toxicity associated with this commonly used... | sodium or calcium polystyrene sulfonate ( kayexalate or analog ) is an ion - exchange resin commonly used to treat hyperkalaemia in patients with chronic kidney disease .
it is known to cause digestive complications , such as nausea , vomiting and constipation .
although rare , colonic necrosis and perforation are... | [
2,
115,
136,
437,
692,
110,
108,
145,
799,
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437,
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1568,
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130,
114,
711,
113,
109,
110,... |
it was recently suggested that endometriosis may commence as an endometrial disease provoked by the aberrant expression of aromatase in this tissue , as this appears to play a pivotal role in its survival in ectopic locations.4 gene array studies have shown that the expression profiles of endometriosis lesions and the ... | objectiveto investigate whether aromatase expression in the eutopic endometrium correlates with the presence and severity of endometriosis in patients with infertility and/or dysmenorrhea undergoing laparoscopy and hysteroscopy.patientsthe study involved 106 patients of reproductive age with symptoms of dysmenorrhea a... | [
2,
2834,
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110,
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110,
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110,
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110,
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110,
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110,
151,
110,
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110,
151,
110,
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110,
151,
110,
151,
110,
... |
we also classified patients based on age , sex , performance status ( according to the eastern cooperative oncology group ) , international prognostic index ( ipi ) score , presence of b symptoms , clinical stage , serum lactate dehydrogenase ( ldh ) level , primary site and treatment protocol .
clinical staging was de... | background : primary bone lymphoma ( pbl ) is a rare disease and distinct clinicopathological entity .
the optimal treatment strategy is still unclear . because of rarity of pbl
, we report our institute experience in pbl clinicopathological feature and treatment results.methods:28 patients diagnosed with pbl were... | [
2,
2834,
1396,
2834,
110,
151,
110,
151,
110,
151,
110,
151,
110,
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110,
158,
124,
109,
5690,
113,
1044,
122,
110,
57347,
19221,
2201,
29516... |
the dental industry has a long history in the development of dental prostheses to recover a patient 's tooth function.1 as a substitute for teeth , a dental prosthesis must show stable durability , aesthetic value , precise function , and convenient use , as well as biocompatibility in order to perform the desired func... | purposethe purpose of this study was to verify the clinical - feasibility of additive manufacturing by comparing the accuracy of four different manufacturing methods for metal coping : the conventional lost wax technique ( clwt ) ; subtractive methods with wax blank milling ( wbm ) ; and two additive methods , multi j... | [
2,
109,
1396,
113,
136,
692,
140,
112,
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117,
373,
109,
21619,
37862,
499,
141,
7163,
114,
17172,
4051,
113,
109,
4840... |
geriatric population is on rise globally because of increasing life span . as per the us census ,
people above 60 years constituted 6.4% of the total population in 1900 , which increased to 18.4% in 2010 and predicted to go up to 25.5% by 2050.1 spinal problems and spine surgeries in geriatric population are also showi... | background : spine surgery in elderly with comorbidities is reported to have higher complication rates and increased cost . however , the surgical outcome is good irrespective of the complications .
hence , it is essential to identify the factors affecting the complication rates in such patients and the measures to ... | [
2,
145,
731,
124,
109,
15111,
113,
7923,
111,
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908,
110,
108,
7104,
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195,
953,
115,
150,
692,
110,
108,
149,
458,... |
molecular profiling ( mp ) encompasses the testing of multiple biomarkers to evaluate the underlying genetic alterations present in a tumor at any one point in time [ 13 ] . to date molecular profiles may consist of multiple gene mutational analyses , gene copy number changes by fluorescence in situ hybridization ( fis... | the pace of genomic discoveries in the field of cancer is revolutionizing our understanding of the biological dynamics of cancerous growth and , at the same time , fueling research for newer and smarter cancer therapies to reverse the effects of these alterations .
these dynamics are driving a tremendous paradigm sh... | [
2,
10403,
24535,
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107,
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2250,
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19125,
1014,
112,
1776,
... |
microfluidics is the science and technology that deals with fluids usually in the range of microliters ( 10 ) to picoliters ( 10 ) .
since microfluidics typically deals with fluids in the microliter scale , it has several advantages , including low consumption of samples , short analysis time , and high sensitivity [ 1... | microfluidics is considered an important technology that is suitable for numerous biomedical applications , including cancer diagnosis , metastasis , drug delivery , and tissue engineering .
although microfluidics is still considered to be a new approach in urological research , several pioneering studies have been ... | [
2,
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133,
174,
1184,
112,
630,
16... |
the prevalence of overweight and obesity among children and adolescents has widely increased worldwide [ 1 , 2 ] , making it one of the most common chronic disorders in this age group and in adulthood .
the use of body mass index ( bmi ) for age to define being overweight and obese in children and adolescents is well... |
objective . to review the extant literature on the prevalence of overweight and obesity in adolescents ( 1019 years old ) of both sexes
.
design .
the search was carried out using medline and scopus considering articles published from the establishment of the databanks until june 7 , 2012 .
data on the preva... | [
2,
109,
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113,
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109,
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4224,
143,
3027,
6120,
110,
1... |
an institutional review board approved this retrospective analysis , which was performed at the department of general surgery , xinhua hospital , school of medicine , shanghai jiao tong university . from january 2009 to september 2014 , 220 consecutive patients with bile duct stones ( 152 ) or a common bile duct ( cbd ... | objectives : the aim of this study was to evaluate the usefulness of the conventional side - viewing duodenoscope for successful endoscopic retrograde cholangiopancreatography ( ercp ) in postgastrectomy patients.methods:a total of 220 consecutive patients with bile duct stones or a distal common bile duct stricture w... | [
2,
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151,
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111,
195,
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118,
110,
420,
28773,
110,
107,
2834,
... |
the treatment of intracranial aneurysms has been revolutionized by the introduction of detachable coils for endovascular therapy , and it has been demonstrated that it is a safe and effective method for treating aneurysms .
it is not unusual , however , to encounter either transient or permanent ischemic events after e... | background : despite increasing acceptance of endovascular coiling for treating anterior communicating artery ( acoa ) aneurysms , anterior circulation cerebral infarction ( aci ) after embolization remains a limitation . with higher incidence ,
higher morbidity and higher mortality , it is one of the main factors i... | [
2,
109,
887,
1958,
118,
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109,
582,
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109,
887,
1958,
162,
756,
112,... |
neck pain is a common musculoskeletal disorder in modern society that can produce severe
pain .
67% of the population suffers from it at least once in a lifetime and the prevalence
is about 23%1 .
the pain exacerbates and
fades periodically , and many patients do not fully recover from the symptoms2 .
neck pain o... | [ purpose ] this study evaluated joint mobilization and therapeutic exercise applied to the
cervical spine and upper thoracic spine for functional impairment caused by chronic neck
pain .
[ subjects and methods ] eighteen study subjects were randomly assigned to two groups
of nine people each .
therapeutic e... | [
2,
109,
1396,
113,
136,
692,
140,
112,
5731,
109,
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113,
6839,
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8633,
109,
6115,
456,
122,
456,
112,
162,
209,
8103,
1855,
195,
2140,
110,
... |
the indications for laparoscopic pyeloplasty are flank pain , infection , stone formation , and decreased renal function .
many studies have reported that laparoscopic pyeloplasty has an excellent success rate ranging from 9098% [ 15 ] .
success is usually defined as improvement in hydronephrosis , as determined by ult... | objectivewe evaluated the improvement of hydronephrosis longitudinally after laparoscopic dismembered anderson
hynes pyeloplasty in adult patients with ureteropelvic junction obstruction.material and methodssixteen patients underwent laparoscopic pyeloplasty at our institution between january 2006 and june 2012 .
... | [
2,
109,
2757,
113,
109,
1393,
113,
13222,
2979,
45836,
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3035,
141,
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111,
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26669,
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143,
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16088,
18228,
15731,
143,
164,
8959,
110,
158,
117,
8905,
115,
1195,
1044,
... |
this retrospective study was approved by the institutional review board of our hospital ( 2014 - 09 - 037 ) . between november 2011 and october 2014 ,
245 patients in the icu underwent bedside pdt with a ciaglia blue rhino percutaneous tracheostomy set ( cook medical , bloomington , in , usa ) due to prolonged endotrac... | when first introduced , percutaneous dilatational tracheostomy ( pdt ) was performed using a bronchoscope .
the bronchoscope itself , however , has several disadvantages , including interruption of ventilation .
modifications of the standard pdt technique have suggested that pdt can be safely performed without a b... | [
2,
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109,
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252,
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347,
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26978,
64372,
132,
23277,
51286... |
hypertension ( htn ) is the most common comorbidity in the world with significant public health implications [ 1 , 2 ] . the overall u.s .
prevalence of hypertension among adults ages 18 years in 20052008 was 30.9% and was highest among persons ages 65 years ( 69.7% ) and non - hispanic blacks ( 44% ) .
the... | hypertension ( htn ) is the most common co - morbidity in the world , and its sequelae , heart failure ( hf ) is one of most common causes of mortality and morbidity in the world .
current understanding of pathophysiology and management of htn in hf is mainly based on studies , which have mainly included whites . am... | [
2,
109,
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113,
773,
2939,
143,
110,
67913,
110,
158,
115,
63247,
15981,
116,
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4567,
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109,
956,
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111,
117,
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887,
2634,
118,
10856,
1568,
143,
110,
67913,
110,
158,
110,
108,
6591,
110,... |
strains carrying proa - tev - rpt1 were grown in 6 l of sd medium to od600 0.8 to 1.2 .
cells were harvested , washed once with ice - cold water and drop - frozen in liquid nitrogen .
frozen yeast samples were then ground using an mm301 grinding mill ( restch ) under liquid nitrogen following manufacturer s instruction... | substrates of the proteasome are recognized and unfolded by the regulatory particle ( rp ) , then translocated into the core particle ( cp ) to be degraded1 .
a hetero - hexameric atpase ring , containing subunits rpt1-rpt6 , is situated within the base subassembly of the rp1 .
the atpase ring sits atop the cp , w... | [
2,
145,
731,
124,
109,
874,
110,
108,
110,
37483,
17340,
110,
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111,
110,
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304,
233,
110,
144,
11933,
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110,
20672,
144,
740,
14689,
115,
44966,
951,
... |
this was a retrospective study of 18 patients with inflammatory myofibroblastic tumors , diagnosed in the department of general pathology during the period of january 2011december 2015 .
10200 ) . the clinical details and follow - up information of each patient were noted from the clinical work station .
all classical ... | backgroundinflammatory myofibroblastic tumor is a histopathologically distinctive neoplasm of children and young adults . according to world health organization ( who ) classification
, inflammatory myofibroblastic tumor is an intermediate - grade tumor , with potential for recurrence and rare metastasis .
there a... | [
2,
2834,
1396,
110,
151,
2834,
109,
1396,
113,
136,
692,
117,
112,
799,
114,
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113,
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161,
554,
56344,
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2288,
17573,
110,
107,
2834,
1625,
110,
151,
2834,
109,
17573,
195,
8015,
992,
112,
153,
4... |
improving the effectiveness and efficiency of the informed consent process is a critical health policy issue .
informed consent is an essential element of ethical biomedical research , with federal regulatory requirements that are intended to ensure autonomy of the research participant s decision to engage in research ... | backgroundinformed consent is the cornerstone for protection of human subjects in clinical trials .
however , a growing body of evidence suggests that reform of the informed consent process in the united states is needed.methodsthe clinical trials transformation initiative conducted interviews with 25 experienced ob... | [
2,
6137,
141,
114,
1222,
513,
113,
1812,
8980,
120,
109,
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5199,
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143,
2895,
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110,
158,
2365,
109,
2976,
4898,
405,
110,
107,... |
one of the main objectives of orthodontic treatment and/or orthognathic surgery is to improve facial harmony and beauty .
although the perception of these characteristics varies according to cultures , socioeconomic status , and era , clinicians have traditionally measured the distance , angulation , and proportion of ... | objectiveto investigate the effects of frontal facial type ( fft ) and sex on preferred chin projection ( cp ) in three - dimensional ( 3d ) facial images.methodssix 3d facial images were acquired using a 3d facial scanner ( euryprosopic [ eury - fft ] , mesoprosopic [ meso - fft ] , and leptoprosopic [ lepto - fft ] ... | [
2,
1670,
109,
12469,
137,
129,
1828,
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114,
1644,
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132,
2717,
71552,
5551,
12469,
197,
114,
1644,
12469,
110,
107,
109,
1396,
113,... |
intrathecal baclofen ( itb ) is becoming a popular modality for management of severe spasticity [ 13 ] .
spasticity is defined as hypertonia in which one or both of the following signs are present ( 1 ) resistance to externally imposed movement that increases with increasing speed of stretch and varies with the direc... | increasingly , spasticity is managed with surgically implanted intrathecal baclofen pumps .
intrathecal baclofen pump revision surgery unrelated to programmable pump end - of - life is not uncommon , requiring special attention during pre- , intra- , and postoperative management .
we aimed to identify and describe... | [
2,
2834,
1396,
110,
151,
2834,
17763,
544,
11944,
13160,
33115,
22872,
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126,
1271,
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114,
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60248,
110,
107,
802,
110,
108,
7923,
113,
126,
1271,
137,
2902,
110,
107,
... |
human capital and health improvement programmes are of central importance towards sustainable development and economic growth in any country . in malaysia
, the health care system has changed from traditional remedies to meeting the emerging needs of the population . since the independence of malaysia in 1957 ,
the fir... | since 1957 , there has been major reorganization of health care services in malaysia .
this article assesses the changes and challenges in health care delivery in malaysia and how the management in health care processes has evolved over the years including equitable health care and health care financing .
the heal... | [
2,
115,
136,
800,
110,
108,
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779,
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4714,
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426,
406,
110,
108,
883,
1863,
... |
black yeasts from the family herpotrichiellaceae ( order chaetothyriales ) are fungi with a remarkable dual ecology . on the one hand , they have a unique ability to adapt to extreme environments ( exposure to toxic chemicals , high temperature , scarcity of nutrients , acidic , and/or dry conditions ) , while on the o... | black yeast members of the herpotrichiellaceae present a complex ecological behavior : they are often isolated from rather extreme environments polluted with aromatic hydrocarbons , while they are also regularly involved in human opportunistic infections .
a selective technique to promote the in vitro growth of herp... | [
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810,
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110,
108,
157,
133,
3686,
114,
620... |
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