text stringlengths 117 334k | target stringlengths 20 2.97k | evaluation_predictions list |
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acute exacerbations of copd are characterized by a change in cough , sputum production , and respiratory symptoms from baseline that cause the patient to seek medical attention and involve increasing the dose and/or frequency of existing bronchodilator therapy .
systemic corticosteroids are also recommended in patients... | acute exacerbations of copd can complicate the course of the disease in patients with severe airway obstruction .
reduction of exacerbations is an important clinical outcome in evaluating new therapies in copd .
combination therapies with long - acting -agonists and inhaled corticosteroids have now been approved f... | [
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reverse shoulder prosthesis is an excellent surgical option for patients with certain shoulder pathologies , of which rotator cuff arthropathy is one .
one area where we are gaining a greater understanding is that of managing acromial pathology .
recent studies are showing that not all acromial pathology is a contraind... | fractures of the acromion and scapula are known to occur after reverse shoulder arthroplasty .
we present a case of a fracture at the base of the acromion 5 months after arthroplasty treated successfully with dual plating of the acromion .
eighteen months after fracture fixation , the patient had 160 degrees of ac... | [
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besides its classical role in calcium and bone homeostasis , vitamin d is considered a potent immunomodulator that can affect the pathogenesis of several autoimmune diseases .
our aim is to evaluate the effect of vitamin d correction to a patient with new onset graves disease ( gd ) with an underlying vitamin d deficie... | objectivebesides its classical role in calcium and bone homeostasis , vitamin d is considered a potent immunomodulator that can affect the pathogenesis of several autoimmune diseases .
our aim is to evaluate the effect of vitamin d correction to a patient with new onset graves disease ( gd ) with an underlying vitam... | [
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nigella sativa l. ( ns ) is a vegetal specie of the ranunculaceae family , commonly known as black cumin seed , neguilla or ajemuz , that is widely cultivated in the mediterranean region .
its seeds have played an important role over the years in ancient islamic system of herbal medicine and in spain , where ... |
nigella sativa l. ( ns ) has been used for medicinal purposes since ancient times . this
study aimed to investigate the cytotoxicity of ns dry methanolic extract on cultured
cortical neurons and its influence on neurotransmitter release , as well as the presence of
excitatory ( glutamate and aspartate ) and in... | [
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pheochromocytomas are rare catecholamine producing tumors arising from chromaffine cells in the sympatho adrenal system .
its prevalence is estimated at 0.1% to 0.6% . they secrete various catecholamines , predominantly norepinephrine , and epinephrine to small extent .
these catecholamines are responsible for the mani... | pheochromocytomas have been described in association with vascular abnormalities like renal artery stenosis .
a 48-year - old man was admitted to our hospital with the complaints of headache , sweating , anxiety , dizziness , nausea , vomiting and hypertension . for last several days , he was having a dull aching ab... | [
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in recent years , core training has been widely studied since it has been considered a pivotal issue in health , rehabilitation and sports performance ( hibbs et al . , 2008 ) .
however , the definition of the core varies with the interpretation of the literature ( hibbs and thompson , 2008 ) .
anatomically , the core ... | abstracta quantitative observational laboratory study was conducted to characterize and classify core training exercises executed in a suspension modality on the base of muscle activation . in a prospective single - group repeated measures design
, seventeen active male participants performed four suspension exercis... | [
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acute mountain sickness ( ams ) occurs during exposure to high altitude ( ha ) and is a clinical syndrome characterised by headache , insomnia , malaise , and gastrointestinal symptoms .
it is common , developing in 1030% at 25003000 meters and in up to 60% of those ascending to around 4500 meters .
it causes signi... | acute mountain sickness ( ams ) is a common clinical challenge at high altitude ( ha ) . a point - of - care biochemical marker for ams could have widespread utility .
neutrophil gelatinase - associated lipocalin ( ngal ) rises in response to renal injury , inflammation and oxidative stress .
we investigated wheth... | [
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from may 1 through july 30 , 2007 , a total of 29 cases of locally acquired cyclospora infection were reported in british columbia ( figure 1 ; table 1 ) .
an initial investigation was conducted around the 6 laboratory - confirmed case - patients reported in the last 2 weeks of may and the first week of june ( phase 1 ... | investigations of community outbreaks of cyclosporiasis are challenged by case - patients poor recall of exposure resulting from lags in detection and the stealthy nature of food vehicles .
we combined multiple techniques , including early consultation with food regulators , traceback of suspected items , and grocer... | [
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brucellosis is a zoonotic disease mostly transmitted to humans through consumption of unpasteurized dairy products and can lead to a systemic disease with any organ involvement . in this report , we describe a case of brucellosis - induced avascular necrosis of the hip .
brucellosis was diagnosed through serological te... | backgroundbrucellosis is a zoonotic disease mostly transmitted to humans through consumption of unpasteurized dairy products and can lead to a systemic disease with any organ involvement . in this report , we describe a case of brucellosis - induced avascular necrosis of the hip .
brucellosis was diagnosed through s... | [
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, more than 9000 articles related to sids were published and over 100 sids explanations appeared in medical hypotheses .
sids occurs when an infant dies suddenly , unexpected by history , and without a cause found at forensic autopsy or thorough death - scene investigation . in the past four decades several multifact... | the sudden infant death syndrome ( sids ) has four distinctive characteristics that must be explained by any theory proposed for it .
( 1 ) a characteristic male fraction of approximately 0.61 for all postneonatal sids in the us ; ( 2 ) a distinctive lognormal - type age distribution arising from zero at birth , m... | [
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a 56-year - old man was referred for biliopancreatic diversion with a duodenal switch ( bpd - ds ) for intractable complications associated with morbid obesity .
he had been unable to lose weight with orlistat 120 mg three times a day for three months .
the patient had diabetes mellitus for twenty years associated with... | backgroundsevere obesity is associated with important morbidity and increased mortality .
the successes of lifestyle modifications and drug therapy have been partial and mostly unsustained in reducing obesity and its comorbidities .
bariatric surgery , particularly biliopancreatic diversion with duodenal switch re... | [
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the immunosuppressive receptor pd-1 and its ligand pd - l1 have been identified by dr .
tasuku honjo and his colleagues at the kyoto university as factors that
induce programmed cell death .
since the mechanism mediated by pd-1 and its ligand was shown to be important for immune
suppression and tolerance , it has a... | recently , dysfunction of antigen - specific t cells is well documented as t - cell exhaustion and has been defined by the loss of effector functions during chronic
infections and cancer in human .
the exhausted t cells are characterized phenotypically by the surface expression of immunoinhibitory receptors , such... | [
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all bacterial isolates related to the outbreaks ( 1 per patient ) were obtained from clinical samples .
the strains were identified phenotypically by rapid i d 32 strep ( biomrieux , marcy letoile , france ) , which yielded profile 22025001100 ( leuconostoc spp .
( biolog , hayward , ca , usa ) ( 98% , t = 0.708 ) .
th... | from july 2003 through october 2004 , 42 patients became infected by strains of leuconostoc mesenteroides subsp .
mesenteroides ( genotype 1 ) in different departments of juan canalejo hospital in northwest spain . during 2006
, 6 inpatients , also in different departments of the hospital , became infected ( genot... | [
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the work of korean medical radiological technologists is divided into three areas :
diagnosis , treatment , and nuclear medicine1 .
the department of diagnostic radiology ( department of radiology ) is
in charge of general x - ray examinations , magnetic resonance imaging , ultrasonography , and
computerized tomo... | [ purpose ] the aim of this study was to analyze , through ergonomic analyses , those motions
most used by radiological technologists that can cause musculoskeletal disorders .
[ subjects and methods ] the subjects were 7 radiological technologists with work experience
in hospitals for more than 5 years . for t... | [
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blood is an invaluable , life - sustaining fluid . without a sufficient amount of blood
, the cells of the human body could not receive adequate oxygen and nutrients they need to survive .
large volume of blood could be lost as a result of numerously varying serious conditions such as road traffic accidents , obstetric... |
background . though world health organization recommends 100% voluntary blood donation , the percentage of blood collected from voluntary blood donors and the average annual blood collection rate are extremely low in ethiopia .
the role of adults is crucial to meet the demand of safe blood .
thus , this study ai... | [
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the uptake of large amounts of lipids from plasma lipoproteins via endocytosis by macrophages in the artery wall to form lipid - engorged foam cells is an important initiating event in the development of atherosclerosis , a major cause of heart disease .
the main lipoprotein implicated is low - density lipoprotein ( ld... | myosin vi ( myo6 ) functions in endocytosis in conjunction with binding partners including adaptor protein ( ap)-2 , disabled 2 ( dab2 ) , and gaip interacting protein c terminus 1 ( gipc1 ) .
this study aimed to investigate the expression and function of myo6 in macrophages and its possible role in the endocytosis ... | [
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congenital bochdalek hernia ( cbh ) develops as a result of the inappropriate fusion of the pleuroperitoneal fold and septum transversum at the site of the posterolateral lumbocostal trigone at the sixth week of gestation .
this entity was first described by mccauley in 1754 and then by vincent alexander bochdalek in 1... | congenital bochdalek hernia is a defect of the diaphragm and very rare in adults .
only around 100 cases have been reported in the literature . herein , we present a case with a recurrent ovarian cancer who underwent secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy .
an oval defect wit... | [
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a 4-year - old male neutered domestic shorthair cat was presented to the oregon state university cardiology service for suspected pericardial effusion . cardiac tamponade was documented and pericardiocentesis yielded purulent fluid with cytologic results supportive of bacterial pericarditis .
the microbial population c... | case summarya 4-year - old male neutered domestic shorthair cat was presented to the oregon state university cardiology service for suspected pericardial effusion .
cardiac tamponade was documented and pericardiocentesis yielded purulent fluid with cytologic results supportive of bacterial pericarditis .
the micro... | [
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maxillary sinus pneumatization can pose a surgical hazard in terms of oro - antral communications following extraction and endodontic surgery of the antral related teeth .
it also increases the risk of introducing foreign bodies , root tips , or teeth displacement into the sinus cavity , and it is well known to influ... | considering the anatomical variability related to the maxillary sinus , its intimate relation to the maxillary posterior teeth and because of all the implications that pneumatization may possess , three - dimensional assessment of maxillary sinus pneumatization is of most usefulness .
the aim of this study is to ana... | [
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many rnas function as folded , structured molecules rather than as protein - encoding messengers . in fact , highly conserved , structured non - coding rnas ( ncrnas ) essential to basic cellular processes represent the majority of a cell 's rna .
such ncrnas are responsible for translation , pre - mrna splicing , hist... | previous efforts to determine structures of non - coding rna ( ncrna ) probed only one rna at a time with enzymes and chemicals , using gel electrophoresis to identify reactive positions . to accelerate rna structure inference ,
we have developed fragseq , a high - throughput rna structure probing method that uses h... | [
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a 45-year - old iranian woman was referred to the private clinic in the city of hamadan for implant consultation .
her past medical history was not notable , and there was no evidence of systemic disease .
she had no history of trauma to the mandible . in the extra - oral examination ,
intra - oral examination revealed... | periapical cemento - osseous dysplasia ( pcod ) is a subtype of cemento - osseous dysplasia that usually occurs in middle - aged black women .
this report described a case of a 45-year - old iranian woman who was diagnosed with pcod on the basis of cone beam computed tomographic ( cbct ) findings .
cbct enabled de... | [
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worldwide , the population with diabetes is currently estimated at 366 million and is expected to exceed half a billion by 2030 .
foot ulcers are the principal cause of severe complications and hospitalization among patients with diabetes , substantially increasing the costs with this disease . in the united states ,
t... | the aim of this study was to identify and quantify risk factors for amputation in diabetic patients hospitalized for foot infections .
this cross - sectional study comprised 100 patients with diabetic infectious complications in the lower limbs .
the variables investigated were related to diabetes , infection , an... | [
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microcystic adnexal carcinoma ( mac ) is a rare malignant cutaneous neoplasm with pilar and eccrine gland differentiation .
mac was first described as a separate clinical entity by goldstein et al in 1982 .
it is locally aggressive but rarely metastasizes , usually presenting as a slow growing asymptomatic lesion on th... | we present a case report of a microcystic adnexal carcinoma on the cheek of a 67-year - old man .
clinical , dermatoscopic and dermatopathologic images are presented .
a search of the literature has not discovered any previously published dermatoscopy images of microcystic adenexal carcinoma . | [
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neurofibromatosis type-1 ( nf-1 ) is a multisystem , autosomal dominant disorder of peripheral nerves affecting nearly 1/3000 individuals worldwide.1 it was first described by a german pathologist , friedrich daniel von recklinghausen .
inherited or spontaneous mutation of the neurofibromin gene located on chromosome 1... | skeletal neurofibromatosis ( nf ) commonly manifests as scoliosis and tibial dysplasias .
nf affecting the pelvic girdle is extremely rare .
pathological fracture of the acetabulum leading to anterior hip dislocation in a patient with nf-1 has never been reported in the literature .
the paper presents the clinic... | [
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recent papers by and show the application of fractional calculus to pharmacokinetics ( pk ) .
leffler function : \documentclass[12pt]{minimal }
\usepackage{amsmath }
\usepackage{wasysym }
\usepackage{amsfonts }
\usepackage{amssymb }
\usepackage{amsbsy }
\usepackage{mathrsfs }
... | systems of fractional differential equations ( sfde ) have been increasingly used to represent physical and control system , and have been recently proposed for use in pharmacokinetics ( pk ) by ( j pharmacokinet pharmacodyn 36:165178 , 2009 ) and ( j phamacokinet pharmacodyn , 2010 ) .
we contribute to the developm... | [
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117,
478,
167,
... |
it is caused by a complex interplay of
motor , sensory , and cognitive impairments2 .
these neurological deficits are the prime cause of reduced quality of
life and social participation3 .
thus , gait
and balance recovery is regarded as a chief goal in stroke rehabilitation4 . until now
, various exercise program... | [ purpose ] the objective of this study was to investigate the effects of stationary
cycling exercise on the balance and gait abilities of chronic stroke patients . [ subjects ]
thirty - two chronic stroke patients were randomly assigned to an experimental group ( n=16 )
or a control group ( n=16 ) .
[ methods... | [
2,
109,
2560,
113,
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692,
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17042,
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228,
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151,
109,
7707,
456,
... |
since the particle size is
a key consideration in nuclear transport , three nps of different sizes
( 15.0 1.2 , 8.5 0.8 , and 5.5 0.8 nm , respectively )
were synthesized to study the size effect of the nanoparticle on nuclear
internalization ( see tem images in figure s1 ) .
after modification with a dense ... | the development of multidrug resistance
( mdr ) has become an increasingly serious problem in cancer therapy .
the cell - membrane overexpression of p - glycoprotein ( p - gp ) , which can
actively efflux various anticancer drugs from the cell , is a major
mechanism of mdr .
nuclear - uptake nanodrug deliver... | [
2,
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4573,
2725,
148,
146,... |
type 1 diabetes ( t1d ) , is a chronic autoimmune disease and it is common in children the body 's own immune system attacks the beta - cells in the islets of langerhans of the pancreas , destroying or damaging them .
it can lead to long - term complications including cardiovascular disease , blindness and kidney failu... | background : regulatory t cells have an important role in the control of immune reactivity against self antigens and probably play a role in pathogenesis of type 1 diabetes ( t1d ) .
we aimed to determine the frequency of regulatory t cells in recently diagnosed children with / t1d.materials and methods:20 children ... | [
2,
619,
305,
5040,
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252,
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15839,
113,
30672,
420,
8457,
116,
113,
10... |
an increased man - made radiation exposure - risk from the use of high - dose imaging modalities such as computed tomography and angiographic suites is now being observed in many health - care centers with over 3.6 million diagnostic examinations performed annually worldwide .
interventional procedures are performed by... | flat panel detector ( fpd ) technology in interventional cardiology is on the increase due to its varied advantages compared to the conventional image intensifier ( ii ) systems .
it is not clear whether fpd imparts lower radiation doses compared to ii systems though a few studies support this finding .
this study... | [
2,
109,
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158,
121,
936,
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65005,
54742,
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114,
26887,
9310,
1104,
120,
... |
a pure ground - glass nodule ( ggn ) in the lung may represent an early lung malignancy , such as adenocarcinoma in situ ( ais ) or minimally invasive adenocarcinoma ( mia ) ( 1 ) .
approximately 20 - 30% of patients with adenocarcinoma and a predominantly pure ggn who undergo surgery have additional ggn lesions , eith... | treatments for pure ground - glass nodules ( ggns ) include limited resection ; however , surgery is not always possible in patients with limited pulmonary functional reserve . in such patients
, cryoablation may be a suitable alternative to treat a pure ggn . here , we report our initial experience with cryoablatio... | [
2,
145,
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1250,
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53199,
8198,
16349,
... |
despite positive changes in professional definitions , such as removal of homosexuality from dsm in 1973 , deviations from gender specific heterosexual development still constitute a reason for concern for most of the parents .
unique stressors associated with homosexuality such as stigma , discrimination and bully vic... | both youngsters and adults with same - sex attraction are at greater risk for negative health outcomes . despite mounting efforts to determine the biological background ,
a satisfactory conclusion has not been reached and there is a need to explore alternate factors like functioning of thyroid system during pregnanc... | [
2,
136,
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211,
751,
113,
109,... |
women with psychiatric diseases are treated with antipsychotic medication(s ) with limited evidence to support the safety of their use during pregnancy.olanzapine , a second - generation antipsychotic , is a us food and drug administration pregnancy category c drug with no unequivocal evidence of harm to the fetus.w... | there is a dearth of evidence on the safety of the use of antipsychotics during pregnancy .
olanzapine , a pregnancy category c drug , has no unequivocal evidence of harm to the fetus . against this backdrop
, we report the first case of a tracheo - esophageal fistula ( tef ) in a newborn following maternal anten... | [
2,
115,
136,
800,
110,
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145,
731,
109,
211,
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23349,
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106,
145,
731,
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113,
114,
1590,
1... |
viruses are divided into two similar - sized groups depending on whether the virus particle contains dna or rna , and , as causes of human fatality , rna viruses are by far the more important ( 1 ) . new viral diseases continue to appear as a result of several changes in human activity : travel , population growth , in... | the rna virus database is a database and web application describing the genome organization and providing analytical tools for the 938 known species of rna virus .
it can identify submitted nucleotide sequences , can place them into multiple whole - genome alignments ( in species where more than one isolate has been... | [
2,
145,
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134,
150,
6803,
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378,
143,
2231,
1228,
9806,
107,
28704,
107,
... |
adult - onset still 's disease ( aosd ) is a rare inflammatory disease of unknown etiology , which commonly affects young adults .
it is usually characterized by high spiking fevers , arthritis , and an evanescent , nonpruritic , macular and salmon coloured rash , appearing on the trunk and the extremities .
important ... | adult - onset still 's disease ( aosd ) is a systemic inflammatory disorder affecting primarily young individuals .
the diagnosis is primarily clinical and necessitates the exclusion of a wide range of mimicking disorders . given the lack of solid data in regard to the underlying pathogenetic mechanisms , treatment ... | [
2,
109,
66973,
113,
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799,
800,
110,
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4795,
112,
24710,
909,
8628,
115,
80978,
111,
8... |
a healthy 35-year - old man was scheduled for laparoscopic cholecystectomy under general anesthesia for acute cholecystitis .
he had a history of asthma and allergy to animal hair and was treated with a salbutamol inhaler 3 years prior , but showed no symptoms recently .
physical and pre - anesthetic examinations , inc... | we describe a case of a 35-year - old male patient who was scheduled for laparoscopic cholecystectomy and developed a life - threatening anaphylactic reaction 2 min after the administration of sugammadex .
he manifested erythematous wheals on the entire body , dyspnea , hypotension , and tachycardia .
these sympto... | [
2,
2834,
115,
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800,
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108,
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233,
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11059,
54281,
23191,
1... |
amyotrophic lateral sclerosis / parkinsonism - dementia complex ( als / pdc ) is a rare disorder endemic to guam island and the kii peninsula of japan .
it shows a unique combination of parkinsonism , amyotrophy , and dementia , and the form of dementia , which shows a phenotype similar to alzheimer 's disease ( ad ) ,... |
objective .
amyotrophic lateral sclerosis / parkinsonism - dementia complex is classified as one of the tauopathies . methods .
the total tau , phosphorylated tau , and amyloid 42 levels were assayed in cerebrospinal fluid from patients with kii amyotrophic lateral sclerosis / parkinsonism - dementia complex ( n... | [
2,
145,
10082,
88915,
66247,
5651,
143,
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665,
1044,
122,
20230,
457,
... |
in their companion article , tononi and cirelli argue that i have missed the big picture by conflating questions of sleep function with the underlying mechanisms . as i have discussed elsewhere
[ 2 , 3 ] , understanding sleep function is of central importance to biology .
any theory of sleep function must also grapple ... | in a recent article i reviewed an influential theory of sleep function , the synaptic homeostasis hypothesis ( shy . ) according to shy , sleep renormalizes synapses that are potentiated during prior wakefulness .
i concluded that while shy is a seminal theory with important implications about sleep function and t... | [
2,
115,
153,
7706,
974,
110,
108,
112,
7323,
457,
111,
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109,
5910,
7869,
110,
107,
106,
532,
258,
136,
142,
5811,
975,
112,
248,
... |
disporopsis pernyi ( hua ) diels , which belongs to disporopsis genus of liliaceae family , mainly grows in south asia such as vietnam , laos , thailand , and yangtze river basin of china .
it was a well - known traditional chinese medicine which has been widely used for the treatment of abnormal sweating , chronic c... |
disporopsis pernyi ( hua ) diels , which belongs to genus disporopsis , has been widely used for the treatment of abnormal sweating , chronic cough , and so forth .
an ultra - performance liquid chromatography ( uplc ) analysis was developed for the determination of rutin , luteolin , quercetin , and betulinic aci... | [
2,
541,
698,
71649,
20889,
115,
109,
5703,
113,
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446,
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281,
233,
6166,
3919,
52966,
143,
164,
21330,
110,
158,
110,
107,
106,
109,
... |
according to numerous estimations , 15% to 29% of patients with cataract have 1.5 diopters ( d ) of refractive astigmatism.1,2 cataract surgeons usually prefer to treat cataract and correct refractive ( spherical and astigmatic ) disorders at the time of the surgery .
corneal incision ( astigmatic keratotomy ) and peri... | purpose : to present clinical results of toric intraocular lens ( iol ) implantation for preexisting astigmatism correction and determine the time of any postoperative rotation.patients and methods : twenty - nine eyes of 19 patients underwent uncomplicated phacoemulsification and were implanted with an acrysof toric... | [
2,
109,
2560,
113,
136,
692,
117,
112,
731,
109,
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602,
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38620,
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66998,
66475,
10195,
111,
3199,
109,
42459,
9627,
113,
109,
110,
34521,
116,... |
non - st - segment elevation acute coronary syndromes ( nste - acs ) are the most frequent manifestation of acute coronary syndromes ( acs ) .
its morbidity and mortality stays high and even equal to those of patients with st - segment elevation myocardial infarction ( stemi ) during long - term follow - up.1)2 ) curre... | background and objectivesto compare clinical outcomes of staged versus " one - time " percutaneous coronary intervention ( pci ) in intermediate to very high - risk patients with non
st - segment elevation acute coronary syndromes ( nste - acs ) and multivessel coronary disease ( mvd).subjects and methods1531 nste ... | [
2,
2834,
1396,
110,
151,
2834,
145,
4607,
112,
4973,
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114,
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12857,
1546,
261,
30117,
23... |
plant traits such as leaf shape , trichomes , leaf surface waxbloom , and chemical compounds can affect the animals associated with the plant ( hare 2002 ; whitham et al .
plant traits may affect both herbivores and predators , and interactions between predators and their prey may be altered to produce indirect ecologi... | crop traits can alter economically important interactions between plants , pests , and biological control agents .
for example , a reduced waxy bloom on the surface of pea plants alters interactions between pea aphids and their natural enemies . in this study
, we assess whether the effect of wax reduction extends... | [
2,
109,
1521,
113,
8654,
3746,
124,
109,
427,
113,
87871,
116,
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14372,
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52882,
208,
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107,
110,
158,
195,
10920,
303,... |
while there is a large body of evidence in favor of a clustering of representations of body effectors in the posterior parietal cortex , recent advances have revealed a hierarchical organization beyond a flat intentional map composed of functionally distinct subdivisions operating in parallel at same level . in particu... | while there is a large body of evidence in favor of a clustering of representations of body effectors in the posterior parietal cortex , recent advances have revealed a hierarchical organization beyond a flat intentional map composed of functionally distinct subdivisions operating in parallel at same level . in partic... | [
2,
277,
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6217,
1152,
110,
158,
110,
108,
909,
8628,
133,
3264,
114,
35022,
1134,
145... |
these include human population density and behaviour , housing type and location , water supply , sewage and waste management systems , land use and irrigation systems , availability and use of vector control programmes , access to health care , and general environmental hygiene .
meteorological factors that influence ... | climate change has the potential to influence the earth 's biological systems , however , its effects on human health are not well defined .
developing nations with limited resources are expected to face a host of health effects due to climate change , including vector - borne and water - borne diseases such as mala... | [
2,
109,
1521,
113,
2354,
411,
124,
883,
426,
110,
108,
533,
7418,
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317,
2354,
111,
426,
110,
108,
533,
7418,
110,
108,
111,
3630,
118,
32462,
23... |
periodontal disease is a multifactorial infectious disease triggered by the development of dental biofilm , which can harm periodontal tissues .
there are several factors which influence periodontitis : personal and social characteristics , behavioral , systemic , genetic and dental factors , and the microbial composit... | this study histometrically evaluated the effect of forced alcohol intake by stressed animals on the severity of ligature - induced periodontitis in rats .
thirty - two rats were randomly divided in four groups : group gal alcohol and ligature ; group gasl alcohol , chronic physical stress , and ligature ; gnc neg... | [
2,
2517,
1568,
117,
114,
1546,
19115,
7434,
1568,
120,
117,
10914,
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109,
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799,
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124,
109,
486,
113,
3170,
6077,
9085,
1568,
115,
114,
2111,
883,
270,
... |
prostate cancer is the second most common cause of cancer death in men in the united states . in the united states , the age - adjusted number of new cases of prostate cancer was 147.8 per 100,000 men per year based on 2007~2011 data and
the age - adjusted number of deaths was 23.0 per 100,000 men per year based on 200... | prostate cancer is the second most common cause of cancer death in men in the united states .
the most common sites of metastasis include the bone , lymph nodes , lung , liver , pleura , and adrenal glands , whereas metastatic prostate cancer involving the gastrointestinal tract has been rarely reported . a 64-year ... | [
2,
145,
731,
109,
437,
113,
114,
21221,
1019,
233,
459,
63247,
233,
15981,
729,
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107,
106,
109,
1532,
196,
114,
941,
689,
113,
15704,
1695,
143,
3957,
19031,
... |
the incidence of acute pancreatitis is increasing around the world , where it is associated with morbidity and even the risk of mortality .
it may presents with various skin manifestations as rash and rarely , with erythematous tender subcutaneous nodules , known as pancreatic panniculitis .
alcohol and gallstones are ... | acute pancreatitis frequently presents with abdomen pain but may presents with various skin manifestations as rash and rarely , pancreatic panniculitis .
metformin , one of the most effective and valuable oral hypoglycemic agents in the biguanide class was linked to acute pancreatitis in few cases . here
, we repo... | [
2,
264,
110,
108,
145,
731,
113,
142,
9000,
437,
113,
20344,
115,
114,
758,
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381,
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169,
5040,
124,
305,
3138,
107,
156,
113,
109,
1848,
437,
117,
11589,
112,
2108,... |
several decades ago , treatments for benign prostatic hyperplasia ( bph ) were almost entirely surgical . during the 1990s , various minimally invasive surgical procedures ( mis ) were developed , including transurethral microwave thermotherapy , transurethral needle ablation , and transurethral laser vaporization .
al... | purposefollowing the introduction of medical therapy for benign prostatic hyperplasia ( bph ) , we determined the effect of the change in trends in medical therapy on the indication and outcome of surgical intervention for bph.materials and methodswe compared the basic characteristics of , weight of resected tissue of... | [
2,
109,
15111,
113,
26056,
2717,
23386,
88978,
143,
3027,
9342,
110,
158,
117,
4567,
115,
1024,
317,
8003,
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231,
113,
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59021,
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1024,
164,
112,
2870,
231,
113,
779,
110,
107,
2409,
109,
8628,
115,
941,
111... |
spinal fusion and pedicle screw fixation techniques are usually used in cases of vertebral fractures , dislocation , scoliosis , kyphosis , spinal tumor and for severe back pain that does not respond to other therapies.123 the pedicular screw fixation offers a stable and safe possibility for stabilization during correc... | background : there is much more radiation exposure to the surgeons during minimally invasive pedicle screws placement . in order to ease the surgeon 's hand - eye coordination and to reduce the iatrogenic radiation injury to the surgeons , a robot assisted percutaneous pedicle screw placement is useful .
this study ... | [
2,
109,
1396,
113,
109,
8823,
692,
117,
112,
1830,
211,
4275,
190,
109,
17890,
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2827,
564,
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233,
6812,
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5589,
110,
107,
106,
1965,
64228,
27318,
53655,
195,
11826,
2870,
4817,
233,
91... |
beyond its role of cellular energy currency and phosphate donor , atp plays a potent signaling role through its extracellular release and activation of cell surface purinergic receptors .
fast responses to atp are mediated through activation of p2x receptors , a family ( p2x1p2x7 ) of atp - activated ligand - gated ion... | release and reception of extracellular atp by leukocytes plays a critical role in immune responses to infection , injury and cardiovascular disease .
leukocytes of both the innate , adaptive immune and central nervous system express a repertoire of cell surface receptors for atp ( p2x and p2y receptors ) and its met... | [
2,
80999,
9100,
48910,
143,
134,
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110,
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2840,
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4267,
112,
134,
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127,
38168,
224,
203,
64914,
1131,
111,
9995,
113,
2201,... |
an increased incidence of hashimoto thyroiditis has been reported in patients with turner
syndrome . in view of its pathogenic relationship with autoimmune thyroiditis
we report the case of a 9-yr - old girl with turner syndrome who developed graves
disease during recombinant human gh therapy , and we discuss previ... | an increased incidence of hashimoto thyroiditis has been reported in patients with
turner syndrome , but several cases of graves disease were also described ten to 20 years
ago .
we report the case of a patient with turner syndrome who developed graves disease ,
3 years after successful treatment with reco... | [
2,
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114,
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110,
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... |
optical coherence tomography ( oct ) is a noninvasive method that evaluates biological tissues by in vivo imaging.1 since its introduction , oct has undergone several improvements and revolutionized the diagnostic , monitoring , and therapeutic approaches to many retinal diseases and glaucoma .
computerized algorithms ... | purposewe aimed to evaluate the effect of cataract surgery on subfoveal choroidal thickness ( ct ) and ganglion cell complex ( gcc ) thickness , as measured by enhanced depth imaging - optical coherence tomography ( oct).methodsthis prospective study included 30 eyes of 30 patients who had undergone uneventful phacoem... | [
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141,... |
defects in many of the molecules that regulate the cell cycle have been implicated in cancer initiation and progression .
these include p53 , rb , p107 and prb2/p130 , and cdk inhibitors ( p15 , p16 , p18 , p19 , p21 , p27 ) , all of which act to prevent cell cycle progression until all repairs to damaged dna have been... | gastric cancer is one of the most common malignancies and a leading cause of cancer mortality worldwide
. the pathogenesis mechanisms of gastric cancer are still not fully clear .
inactivation of tumor suppressor genes and activation of oncogenes caused by genetic and epigenetic alterations are known to play signi... | [
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148,... |
pregnancy has a profound physiological impact on the thyroid gland and thyroid function . during pregnancy ,
the thyroid gland increases in size by 10% in iodine sufficient countries and to a greater extent in iodine deficiency countries .
production of thyroid hormones and iodine requirement both increases by approxim... | background : a previous hospital based study from delhi revealed a high prevalence of hypothyroidism in pregnant women .
several other studies with small sample size also indicate a rising trend of prevalence of hypothyroidism during pregnancy in india.objective:to assess prevalence of hypothyroidism in pregnant wom... | [
2,
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lesch - nyhan syndrome was first recognized and clinically characterized in 1964 by lesch and nyhan , observing two affected brothers .
lns is a rare x - linked recessive disorder , resulting from a mutation on the gene encoding for the enzyme hypoxanthine - guanine phosphoribosyltransferase ( hgprt ) , located on the ... | lesch - nyhan syndrome , described in 1964 by lesch and nyhan , is a x - linked recessive disorder , occurring in 1 : 100000 to 1 : 380000 live births .
lns is characterized by a decrease in activity of hypoxanthine guanine phosphoribosyl transferase , an enzyme involved in purine metabolism , resulting in overp... | [
2,
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the
field of small - molecule organocatalysis via noncovalent interactions
has seen rampant growth over the past decade .
this area , which aims to mimic the mechanisms used by nature in
enzyme catalysis , is attractive due to its potential for high catalyst
tunability and substrate specificity , as well as obv... | a spectrophotometric sensor is described
that provides a useful
assessment of the lumo - lowering provided by catalysts in diels alder
and friedel crafts reactions .
a broad range of 33 hydrogen - bonding
catalysts was assessed with the sensor , and the relative rates in
the above reactions spanned 5 ord... | [
2,
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streptococcus pneumoniae remains a major cause of childhood morbidity and mortality worldwide , particularlyin lower income countries .
pneumococcal diseases are the leading source of vaccine preventable deaths , mostly due to community - acquired pneumonia ( cap ) , accounting for approximately 11% of all deaths in ch... | background and objectives : many surface proteins are implicated in nasopharyngeal colonization and pathogenesis of streptococcus pneumoniae .
some of these factors are candidate antigens for protein based vaccines .
new vaccine designs focus on the surface proteins ( e. g. , pspa and pspc ) and also cytolysin , a... | [
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... |
we report a 32-year - old iranian male diagnosed with a case of miliary tuberculosis affecting the prostate .
computerized tomography increased the clinical suspicion of miliary tuberculosis extending to the prostate where a trans - rectal urethral biopsy was obtained .
a strong clinical suspicion and availability of s... | introductiontuberculosis of the prostate is a rare complication of miliary tuberculosis.case presentationwe report a 32-year - old iranian male diagnosed with a case of miliary tuberculosis affecting the prostate .
the patient was admitted to the hospital with convulsions .
computerized tomography increased the cl... | [
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21905,
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178,
368,
146,
13... |
transversus abdominis plane ( tap ) block is a widely practiced peripheral nerve block , utilized to anesthetize the somatic nerves supplying the anterior abdominal wall by depositing local anesthetic in the neurovascular plane between internal oblique and transversus abdominis muscle layers .
it was introduced in anes... | background and aims : transversus abdominis plane ( tap ) block has been shown to provide postoperative pain relief following various abdominal and inguinal surgeries , but few studies have evaluated its analgesic efficacy for intraoperative analgesia .
we evaluated the efficacy of tap block in providing effective p... | [
2,
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... |
innate immunity is the first line of defense of the body , present throughout evolution from lower ( invertebrate ) to more complex organisms ( vertebrate ) ( 1 ) . in order to rapidly protect
the host against infectious or stressful events , the innate immune cells initiate triggers an inflammatory response .
when not... | macrophages are the main effector cells of innate immunity and are involved in inflammatory and anti - infective processes .
they also have an essential role in maintaining tissue homeostasis , supporting tissue development , and repairing tissue damage .
until few years ago , it was believed that tissue macrophag... | [
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940,
110,
940,
110,
940,
110,
940,
110,
940,
110... |
the term amyotrophic lateral sclerosis ( als ) was first coined by charcot , who postulated the primacy of the upper motor neuron ( umn ) in als pathogenesis.1 assessment of cortical function in als and identification of the characteristic clinical phenotype involving combined upper and lower motor neuron abnormalities... | amyotrophic lateral sclerosis ( als ) is a rapidly progressive neurodegenerative disorder of the motor neurons in the motor cortex , brainstem and spinal cord .
a combination of upper and lower motor neuron dysfunction comprises the clinical als phenotype .
although the als phenotype was first observed by charcot ... | [
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slips , trips and falls ( stfs ) lead recurrently to injuries in occupational situations1 .
these accidents are triggered by a movement
disturbance ( a slip or a trip ) when working , especially when walking .
other movement
disturbances ( a wrench slipping , an arm colliding with a wall , etc . ) can occur in
oc... | workplace design and upkeep , or human factors , are frequently advanced for explaining
so - called occupational slip , trip and fall accidents ( ostfas ) . despite scientific
progress , these accidents , and more broadly occupational accidents with movement
disturbance ( oamds ) , are also commonly considered t... | [
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173,
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10... |
the weissella species are gram - positive , non - spore - forming , heterofermentative , nonmotile , and irregular or coccoid rod - shaped organisms . members of the genus weissella have been isolated from a variety of sources , such as fresh vegetables , fermented silage , meat , or meat products .
several lactic ac... | a gram - positive , nonmotile , irregular , short , rod - shaped new strain of weissella confusa bacterium was isolated from fermented cabbage .
the isolate was physiologically and biochemically characterised .
the 16s rdna was amplified by polymerase chain reaction ( pcr ) .
the isolate was identified as weisse... | [
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4839... |
a young boy , 16 years old , presented with complaints of poor
vision in the left eye since childhood .
, he had a vision of 20/200 in the
right eye ( re ) and 20/20 in the left eye ( le ) .
zonules
were lacking around the fissure between the two lobes [ fig . 1 ] .
2 ] revealed
a bilobed lens in the anterior... | congenital anomalies of the lens include a wide range from lens
coloboma to primary aphakia and doubling of lens .
there have
been few case reports of double lens ; the etiology suggested
is metaplastic changes in the surface ectoderm that leads to
formation of two lens vesicles and hence resulting in double... | [
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307,
68067,
3256,
... |
in every field of dentistry , awareness regarding the importance of preserving tooth tissue is becoming evident .
the current odontologic era is characterized by an increasing move toward less invasive treatment and preventive dentistry .
the search for a more gentle , comfortable , and conservative caries excavation h... | aims and objectives : the chemomechanical caries removal system is made presently available containing a natural proteolytic enzyme for ease in the excavation of infected dentin .
the aim of the study was to evaluate the efficacy and efficiency of caries removal using papacarie and carie-care.materials and methods :... | [
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207,
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140,
3047,
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107,
106,
109,
692,
140... |
the enclosure of eukaryotic genomes within the nuclear envelope evolutionarily generated the necessity to transport macromolecules selectively between nucleus and cytoplasm .
following their synthesis in cytoplasm , histones and nucleic acid polymerases have to reach the nucleus , while specifically cytoplasmic protein... | heterogeneous nuclear ribonucleoproteins ( hnrnps ) are spliceosomal macromolecular assemblages and thus actively participate in pre - mrna metabolism .
they are composed of evolutionarily conserved and tandemly repeated motifs , where both rna - binding and protein - protein recognition occur to achieve cellular ac... | [
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1994,
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... |
the term replication stress describes the slowing or stalling of replication forks by endogenously or exogenously derived impediments to dna polymerization ( zeman and cimprich , 2014 ) .
replication stressors can be local factors , such as dna damage or secondary structures that affect forks randomly as they are enco... | summarynucleotide pool imbalance has been proposed to drive genetic instability in cancer . here , we show that slowing replication forks by depleting nucleotide pools with hydroxyurea ( hu ) can also give rise to both transient and permanent epigenetic instability of a reporter locus , bu-1 , in dt40 cells .
hu ind... | [
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27071,
740,
111,
50907,
52696,
1781,
115... |
gossypiboma refers to a mass resulting from retained cotton , gauze , or sponge accidentally left within the body after surgery .
as indicated in its name , gossypiboma is an iatrogenic outcome reported on rare occasions in various parts of the body with diverse clinical findings , often mistaken radiologically as a tu... | gossypiboma refers to a mass resulting from a retained gauze pad accidentally left within the body after surgery .
although the clinical features are diverse , it is often found incidentally as a mass having an internal cystic change and adhesion to adjacent organs .
abdominal computed tomography ( ct ) is helpful... | [
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35991,... |
while advances in free trade and globalization increase the movement and accelerate the accumulation of invasive species ( lockwood et al .
2005 ) , it is still unclear how introduced populations can successfully establish . as elton ( 1958 ) pointed out , for every successful invasion that occurs , there are enormous... | the mechanisms that facilitate success of an invasive species include both ecological and evolutionary processes . investigating the evolutionary dynamics of founder populations can enhance our understanding of patterns of invasiveness and provide insight into management strategies for controlling further establishmen... | [
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264,
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1... |
stroke is the second leading cause of death worldwide , and the leading cause of neurological disability in adults in developed countries.1
2 recognised risk factors include high blood pressure , heart disease , diabetes , obesity , smoking , alcohol and physical inactivity , but further environmental factors are lik... | objectiveexposure to psychosocial stress has been identified as a possible stroke risk , but the role of stress resilience which may be relevant to chronic exposure is uncertain .
we investigated the association of stress resilience in adolescence with subsequent stroke risk.methodsregister-based cohort study .
so... | [
2,
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1948,
233,
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71846,
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110,
107,
106,
114,
1743,
11... |
malignant salivary gland neoplasms account for < 0.5% of all malignancies and approximately 35% of all head and neck cancers .
progress in understanding the cell biology of salivary gland carcinomas ( sgcs ) and detecting vulnerable molecular pathways may lead to the development of new targeted therapy options in these... | braf is the main effector of kras in the ras - raf - mapk axis , a signaling pathway downstream of egfr .
the activation of this cascade is an important pathway in cancer development and is considered a key pathway for therapeutic molecules .
recent studies in metastatic colorectal cancer found that an oncogenic a... | [
2,
145,
731,
142,
149,
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233,
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551,
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3027,
740,
110,
158,
110,
108,
114,
110,
116,
... |
the contour of the lower face , including the lips and soft - tissue chin , is thought to be closely related to the underlying dentoalveolar structure .
both the upper and the lower lips are known to increase in length during growth and maintain a fairly constant vertical relationship with the edges of the correspondin... | objectiveto investigate the dentoskeletal factors which may predict soft - tissue chin strain during lip closure.methodsthe pretreatment frontal and lateral facial photographs and lateral cephalograms of 209 women ( aged 18 - 30 years ) with angle 's class i or ii malocclusion were examined .
the subjects were categ... | [
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303,
114,
10... |
subjects for this nested case - controlled study were selected from ongoing clinical investigations of skeletal muscle insulin resistance . only female subjects were included to provide a sex - controlled analysis .
women aged 6075 years were recruited through advertisements in the pittsburgh , pa , area . a brief phon... | objectivewe tested the primary hypotheses that sphingolipid and diacylglycerol ( dag ) content is higher within insulin - resistant muscle and that the association between intramyocellular triglycerides ( imtg ) and insulin resistance is muscle fiber type specific.research design and methodsa nested case - control ana... | [
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... |
do czstych powika mcs nale : incydenty zakrzepowe ( w tym zakrzepica urzdzenia ) , incydenty krwotoczne oraz hemoliza .
ocena zmian w czasie wybranych parametrw ukadu krzepnicia u chorych ze schykow niewydolnoci serca leczonych za pomoc mcs i terapii przeciwzakrzepowej .
przez 6 tygodni obserwowano 16 pacjentw ze schyk... | introductionmechanical circulatory support ( mcs ) therapy is associated with the improvement of long - term prognosis in patients with end - stage heart failure . for years
it has been used as a bridge to transplant .
however , more recently it is even being used as a destination therapy .
recently , clinicians... | [
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263,
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302,
613... |
the antimetabolite 5-fluorouracil ( fu ) is widely used in the treatment of solid tumors , including gastrointestinal , breast , head , and neck cancers .
cardiotoxicity , a rare adverse effect of 5-fu , has a reported incidence of 1.2% to 18% .
the patient presented with typical angina and electrocardiographic changes... | cardiotoxicity associated with 5-fluorouracil ( fu ) is an uncommon , but potentially lethal , condition .
the case of an 83-year - old man with colon cancer who developed chest pain during 5-fu infusion is presented .
the electrocardiogram ( ecg ) showed pronounced st elevation in the lateral leads , and the ches... | [
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802,
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2822,
... |
genetic disorders caused by mutations in the -globin gene are widely known as the human -hemoglobinopathies , in which -thalassemia and sickle cell disease ( scd ) are the most prevalent ones , particularly in the mediterranean , africa , and southeast asia , leading to great mortality and morbidity [ 14 ] .
the high o... | for the treatment of -thalassemia and sickle cell disease ( scd ) , pharmacological induction of fetal hemoglobin ( hbf ) production may be a promising approach . to date
, numerous studies have been done on identifying the novel hbf - inducing agents and understanding the underlying mechanism for stimulating the hb... | [
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according to the statistical analysis of the international society of heart and lung transplantation , survival after lung transplantation systematically improves .
88% of recipients survive three months after operation , 79% survive for one year , and about 50 - 60% of recipients survive five years after transplantati... | lung transplantation is a method useful in such non - malignant end - stage parenchymal and vascular diseases as : chronic obstructive pulmonary disease ( copd ) , idiopathic interstitial pulmonary fibrosis , cystic fibrosis , or primary pulmonary hypertension .
the main aim of this procedure is to extend the patien... | [
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a 53-year - old asian woman with a history of lupus erythematosus was initially treated with hydroxychloroquine ( plaquenil , unknown dose ) for 5 years .
approximately 3 years ago , the patient 's medication was changed to chloroquine ( 400 mg daily ) . within a few years of taking chloroquine
, she noticed a circular... | a 53-year - old asian woman was treated with hydroxychloroquine and chloroquine for lupus erythematosus . within a few years
, she noticed circle - shaped shadows in her central vision . upon examination ,
the patient 's visual acuity was 20 / 25 in both eyes .
humphrey visual field ( hvf ) testing revealed a ce... | [
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cardiovascular diseases ( cvd ) are becoming the major cause of mortality in developing countries.1 the 2002 world health report indicates that the most important risk factors for noncommunicable diseases include high blood pressure , high blood cholesterol , inadequate fruit and vegetable intake , overweight and obesi... | because of the enormous changes in the lifestyle of saudis in the last three decades , the risk factors of coronary heart disease ( chd ) , including physical inactivity , are increasingly becoming prevalent in the society .
this paper provides an overview of the importance of physical activity in health promotion a... | [
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cancer , which is commonly a harbinger of imminent patient death , is a group of diseases characterized by uncontrolled growth and spread of abnormal cells and aberrant cell behavior , which leads to expansive masses that destroy surrounding normal tissue and is able to attack vital organs resulting in disseminated dis... | cancer is an inevitable matter of concern in the medicinal chemistry era .
chalcone is the well exploited scaffold in the anticancer domain .
the molecular mechanism of chalcone at cellular level was explored in past decades .
this mini review provides the most recent updates on anticancer potential of chalcones... | [
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premature beats arising from foci other than pulmonary veins have been related to its pathogenesis .
a 64-year - old female underwent superior vena cava ( svc ) isolation after triggers were identified originating from the svc following pulmonary vein isolation ; immediately after svc isolation , she developed junction... | introductionatrial fibrillation is the most common sustained heart arrhythmia .
premature beats arising from foci other than pulmonary veins have been related to its pathogenesis.methods and resultsa 64-year - old female underwent superior vena cava ( svc ) isolation after triggers were identified originating from t... | [
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bilateral ectopic pregnancy is a rare condition and is divided in two subgroups , primary and secondary , based on history of assisted reproductive technology .
a 30 year old primigravid woman with history of infertility and ovulation induction presented to a hospital in kashan in year 2013 .
she had vaginal bleeding ,... | backgroundbilateral ectopic pregnancy is a rare condition and is divided in two subgroups , primary and secondary , based on history of assisted reproductive technology.case presentationa 30 year old primigravid woman with history of infertility and ovulation induction presented to a hospital in kashan in year 2013 . ... | [
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sevoflurane has a low blood / gas partition coefficient and does not irritate the airways .
inhalation induction should provide rapid loss of consciousness to ensure patient 's comfort and satisfaction and to avoid adverse effects such as excitations , breath holding , coughing and/or laryngospasm .
several adjuvants a... | background and aims : inhalation anesthesia with sevoflurane may be enhanced by several drugs or techniques .
the aim of the present study was to investigate the effect of nitrous oxide ( n2o ) pretreatment on the speed of anesthesia induction with sevoflurane.material and methods : eighty patients scheduled for hys... | [
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three types of calibrated microspheres have recently been approved in japan as embolic agents for hypervascular tumors and arteriovenous malformations . to date , two types of embolic microspheres capable of being loaded with drug have been introduced : dc bead ( biocompatibles , farnham , uk ) and hepasphere ( biosphe... | transarterial chemoembolization ( tace ) using a drug - eluting bead ( deb - tace ) for hepatocellular carcinoma ( hcc ) is a new treatment method .
we report on a case of delayed intratumoral hemorrhage after deb - tace .
an 81-year - old male with hepatitis c virus - related cirrhosis was diagnosed with a hcc of... | [
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men , aged > 30 years , with type 2 diabetes were recruited from barnsley hospital nhs trust , barnsley , u.k .
most of the subjects were recruited from the retinal screening program , which is attended by virtually all patients with diabetes in the barnsley area .
subjects were given written and verbal information reg... | objectivethere is a high prevalence of hypogonadism in men with type 2 diabetes .
this will lead to an increase in assessments of hypogonadism .
statins could potentially decrease testosterone levels by reducing the availability of cholesterol for androgen synthesis .
we compared testosterone levels and hypogona... | [
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heart transplantation continues to provide patients with end - stage heart disease with extended survival with a half - life of 9.3 years between 2000 and june 2008 . .
however , despite substantial advancements in immunosuppression , patients continue to be at significant risk for allograft rejection early after cardi... |
purpose .
the most recent international society for heart and lung transplantation ( ishlt ) biopsy scale classifies cellular and antibody - mediated rejections . however , there are cases with acute decline in left ventricular ejection fraction ( lvef 45% ) but no evidence of rejection on biopsy .
characterist... | [
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this investigation includes a series of blood investigations and imaging ; when these investigations found no evidence for a demyelinating disorder ( through mri features principally ) , systemic autoimmune condition ( e.g. , antinuclear antibodies , dna , aquaporin-4 , and myelin oligodendrocyte glycoprotein antibodie... | objective : to identify and follow a series of 52 patients with optic neuropathy related to sarcoidosis.methods:prospective observational cohort study.results:the disorder was more common in women and affected a wide age range .
it was proportionately more common in african and caribbean ethnic groups .
two clinic... | [
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epidemiological studies during the past decade have shown a positive correlation between the general consumption of cruciferous vegetables and decreased incidence of some cancers , including lung , stomach , colon , breast,[23 ] bladder,[45 ] prostate,[67 ] and non - hodgkin lymphoma .
lung cancer risk is reduced espec... | background : sulforaphane ( sfn ) , an activator of nuclear factor erythroid-2 related factor 2 ( nrf2 ) , is a promising chemopreventive agent which is undergoing clinical trial for several diseases .
studies have indicated that there is gain of nrf2 function in lung cancer and other solid tumors because of mutatio... | [
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the ultimate goal of periodontal therapy is to arrest the progress of periodontal disease and regenerate the lost periodontal support .
hyaluronic acid ( ha ) is a high molecular weight , nonsulphated glycosaminoglycan component which is produced during various phases of cell 's life cycle .
it contributes in tissue hy... | interdental papilla construction , especially in the esthetic area , is one of the most challenging tasks .
interdental papilla loss might occur due to several reasons as a consequence of periodontal surgery or trauma .
the purpose of this study is to report the reconstruction of lost interdental papilla using hya... | [
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the global labor force is about 2,600 million and 75% of this force is working in developing countries .
the total labor force in india is estimated to be 317 million , in which the organized sector employs only 26.8 million ( 8.5% ) while the unorganized sector employs as many as 290.2 million ( 91.5% ) .
the indian i... | introduction : employees constitute a large and important sector of the world 's population .
the global labor force is about 2,600 million and 75% of this force is working in developing countries .
occupational health and safety ( ohs ) must be managed in every aspect of their work .
occupational safety and hea... | [
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glaucoma is a leading cause of blindness worldwide.1 despite the growing understanding of its pathophysiology and advances in its treatment , challenges remain regarding how to predict and stop its progression .
the treatment plan for glaucoma depends on its progression rate . in practice , most ophthalmologists determ... | purposewe investigated correlations between short - term and long - term intraocular pressure ( iop ) fluctuations.methodswe examined 50 eyes of glaucoma patients who were followed for > 2 years .
we measured short - term iop fluctuation using a triggerfish contact lens sensor ( cls ) . the short - term iop fluctuat... | [
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we reviewed outbreak reports to identify outbreaks associated with an imported food from the inception of the surveillance system in 1973 through 2014 , the most recent year for which data were available .
we obtained additional data for some outbreaks ( e.g. , country of origin ) from the us food and drug administrati... | the proportion of us food that is imported is increasing ; most seafood and half of fruits are imported .
we identified a small but increasing number of foodborne disease outbreaks associated with imported foods , most commonly fish and produce .
new outbreak investigation tools and federal regulatory authority ar... | [
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bulking agent injection is now a standard treatment for patients with grade 1 - 3 primary vesicoureteral reflux ( vur ) .
patients with higher grades and secondary types of vur show an unacceptably high failure rate when treated with injections of a bulking agent .
collagen has been used for many years as a bulking age... | primary vesicoureteral reflux can be treated by injection of a bulking agent into the wall of the ureterovesical junction . over time , the bulking agent can get calcified .
radiological images of the area show findings that mimic those seen in ureterovesical junction calculi . in this report
, we present the imag... | [
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the mucopolysaccharidoses ( mps ) are a family of genetic disorders characterized by changes in an individual s ability to metabolize mucopolysaccharides , which are complex sugar molecules found in the connective tissue , mucosal fluids , synovial fluid , and other cells throughout the body .
there are six types of mp... | an adolescent with hurler - scheie syndrome is reported .
this now 15 year - old - young woman was initially diagnosed at age 4 .
she was assessed for neurocognitive functioning at ages 5 , 13 , and 15 years .
results show a significant decline in intellectual functioning from the superior range to the average r... | [
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smoking cessation is crucial for a better prognosis in patients with coronary heart disease ( chd)13 and copd.2,4,5 acute heart attacks are associated with high smoking cessation rates . in patients with a first myocardial infarction ( mi ) in the 1970s,3 among whom
78% were smoking , the quitting rate was 55% . in a s... | backgroundpatients with copd have had a lower tendency to quit smoking compared to patients with coronary heart disease ( chd ) .
we wanted to investigate if this is still true in a norwegian population.methodsour data came from the fifth and sixth troms surveys , which took place in 20012002 and 20072008 .
the pr... | [
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cranial nerves were composed of two different histological portions , glial and non - glial portion .
the transitional zone refers to the junction between glial portion and the non - glial peripheral portion .
the most outer layer of brain cortex is coated by pia glial membrane called glial limiting membrane or glial l... | objectivethe aim of this study was to evaluate the microanatomy and histological features of the central myelin in the root exit zone of facial nerve.methodsforty facial nerves with brain stem were obtained from 20 formalin fixed cadavers . among them
17 facial nerves were ruined during preparation and 23 root entry... | [
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engaging in high levels of physical activity is a key strategy for successful maintenance of weight loss .
a study of nearly 4,000 participants in the national weight control registry ( nwcr ) , the largest longitudinal study of successful weight loss maintainers , indicated participants expend 2,621 2,252 kcal per w... | given the importance of physical activity ( pa ) for weight control , identifying strategies to achieve higher pa levels is imperative . we hypothesized that performing a greater variety of self - reported moderate - to - vigorous activities ( mvpas ) would relate to higher objectively measured mvpa minutes in two gro... | [
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the protective effects of vagus nerve during ischemia / reperfusion ( i / r ) have been suggested ( 1 ) .
vagus nerve stimulation decreases the inflammation and the injuries resulted from i / r through affecting neutrophils while vagotomy increases these processes ( 1 ) .
moreover , it has been observed that stimulatio... | objectives : vagal pathways in gastrointestinal tract are the most important pathways that regulate ischemia / reperfusion ( i / r ) .
gastrointestinal tract is one of the important sources of melatonin production .
the aim of this study was to investigate probable protective effect of the interaction between vagu... | [
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a stroke is defined by the who as rapidly developing clinical signs of a focal ( or global ) disturbance of cerebral function , with symptoms lasting 24 h or longer or leading to death , with no apparent cause other than of vascular origin . taking into consideration the cause , the mechanism and the character of mo... | the following manuscript presents two cases of ischemic stroke secondary to traumatic internal carotid artery thrombosis with concomitant middle cerebral artery thrombosis occurring very rarely in the medico - legal practice . penetrating neck trauma due to an occupational accident and multiple head and neck trauma se... | [
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pathological tissue fibrosis is the abnormal accumulation of collagen - rich extracellular matrix ( ecm ) after a chronic or misregulated response to injury that progressively disrupts tissue architecture , leading to tissue stiffness , impaired organ function , and eventually organ failure .
fibrosis is featured in di... | fibrotic diseases contribute to 45% of deaths in the industrialized world , and therefore a better understanding of the pathophysiological mechanisms underlying tissue fibrosis is sorely needed .
we aimed to identify novel modifiers of tissue fibrosis expressed by myofibroblasts and their progenitors in their diseas... | [
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heterogenous vancomycin intermediate staphylococcus aureus ( hvisa ) strains have been reported as indicators for reduced vancomycin susceptibility in s. aureus , and various studies associated its presence with vancomycin treatment failure .
it has been shown that methicillin resistant s. aureus ( mrsa ) has the prope... | in a 3-month study done in hospital kuala lumpur ( hkl ) , 7 out of 320 methicillin resistant staphylococcus aureus isolates were confirmed as heterogeneous vancomycin intermediate s. aureus ( hvisa ) using the glycopeptide resistance detection e - test and population analysis , giving a prevalence rate of 2.19% .
t... | [
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37948,
62946,
4406,
1152,
64794,
10545,
32276,
43947,
66334,
72425,
143,
5124,
59194,
110,
158,
14689,
133,
174,
1668,
112,
129,
1589,
122,
2785,
41129,
... |
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