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{"brief_title": "A Phase I Safety and Immunogenicity Study of HIV p17/p24:Ty-VLP in HIV-1 Seronegative Subjects", "brief_summary": "To evaluate the safety and immunogenicity of HIV p17/p24:Ty-VLP (virus-like particles) vaccine in uninfected volunteers. Specifically, to determine whether the vaccine formulated with and without alum induces CD8+ cytotoxic T lymphocytes ( CTLs ) that may be cross-reactive against multiple HIV-1 stains. Also, to determine whether boosting with the vaccine orally or rectally will help induce mucosal antibody responses. Induction of CD8+ CTL activity is considered a critical property for a candidate vaccine. Additionally, since the majority of HIV-1 infections occur after inoculation of a mucosal surface, it is desirable to induce mucosal immunity as well as systemic immunity. The HIV p17/p24:Ty-VLP vaccine may potentially induce both CTL and mucosal antibody responses against HIV-1.", "detailed_description": "Induction of CD8+ CTL activity is considered a critical property for a candidate vaccine. Additionally, since the majority of HIV-1 infections occur after inoculation of a mucosal surface, it is desirable to induce mucosal immunity as well as systemic immunity. The HIV p17/p24:Ty-VLP vaccine may potentially induce both CTL and mucosal antibody responses against HIV-1. Volunteers receive HIV p17/p24:Ty-VLP vaccine or placebo by IM injection (with or without alum adjuvant) at months 0, 2, and 6, and then either by mouth or rectal enema at months 10 and 11. Volunteers who receive oral vaccine boosting will receive concurrent omeprazole to decrease stomach acid.", "condition": ["HIV Infections"], "intervention_type": ["Biological", "Biological"], "intervention_name": ["HIV p17/p24:Ty-VLP", "Aluminum hydroxide"], "criteria": "Inclusion Criteria Concurrent Medication: Required: - Omeprazole given concurrently in patients receiving the oral vaccine dose. Volunteers must have: - HIV-1 negativity. - Normal history and physical exam. - Lower risk for HIV infection. - CD4 count >= 400 cells/mm3. - Normal urine dipstick with esterase and nitrite. NOTE: - No more than 10 percent of volunteers may be over age 50. Exclusion Criteria Co-existing Condition: Volunteers with the following conditions are excluded: - Positive for hepatitis B surface antigen. - Medical or psychiatric condition (including recent suicidal ideation or present psychosis) that precludes compliance. - Occupational responsibilities that preclude compliance. - Active syphilis (NOTE: If serology is documented to be a false positive or due to a remote (> 6 months) infection, subject is eligible). - Active tuberculosis (NOTE: Subjects with a positive PPD and normal x-ray showing no evidence of TB and who do not require INH therapy are eligible). Volunteers with the following prior conditions are excluded: - History of immunodeficiency, chronic illness, malignancy, autoimmune disease, or use of immunosuppressive medications. - History of cancer unless surgically excised with reasonable assurance of cure. - History of suicide attempts or past psychosis. - History of anaphylaxis or other serious adverse reactions to vaccines. - History of serious allergic reaction requiring hospitalization or emergent medical care. Prior Medication: Excluded: - Prior HIV-1 vaccines or placebo in an HIV vaccine trial. - Live attenuated vaccines within the past 60 days. NOTE: Medically indicated subunit or killed vaccines (e.g., influenza, pneumococcal) do not exclude but should be administered at least 2 weeks prior to HIV immunizations. - Experimental agents within the past 30 days. Prior Treatment: Excluded: - Blood products or immunoglobulin within the past 6 months. Higher risk behavior for HIV infection as determined by screening questionnaire, including: - History of injection drug use within the past year. - Higher or intermediate risk sexual behavior.", "gender": "All", "minimum_age": "18 Years", "maximum_age": "60 Years", "healthy_volunteers": "Accepts Healthy Volunteers", "keyword": "HIV Preventive Vaccine", "mesh_term": ["HIV Infections", "Aluminum Hydroxide"], "id": "NCT00001053"}
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The other has the various rebel groups, such as the ZANLA supported by Mao and the ZIPRA backed by the USSR. <br><br>- Forces are asymmetrical, as even if the Rhodesian are few in numbers, they are the only ones to have an air force and their special units are excellent. <br><br>- The Rebels are quite numerous and all around Rhodesia, extending the number of front lines, but their power is rather limited.<br><br>The population morale level is essential as if it falls too low, the Rhodesian player loses the game.<br><br>The game event cards allow full replay ability thanks to the numerous various situations that their create on the diplomatic, military, political or economical fields.<br><br>Estimated Playtime: 2h00<br><br>Favored Side: none<br><br>Hardest to Play: none.","about_the_game":"<img src=\"https:\/\/steamcdn-a.akamaihd.net\/steam\/apps\/574967\/extras\/Rhodesia1972.png?t=1544890312\" ><br><br><strong>Rhodesia 1972<\/strong> is the story of the isolated white rule in Rhodesia, trying to establish a stable and lasting state against the black rebels supported by Communist powers. <br><br>The Rebels will try to unbalance the white population's morale by infiltrating as many fighters group inside the borders as possible. <br><br>The Rhodesian forces will have to repel them and hold their morale till the elections of 1979.<br><br>Rhodesia 1972 lasts 18 turns each representing about 6 months between end of 1972 and early 1980. One player is the white settlers ruling Rhodesia, diplomatically isolated. The other has the various rebel groups, such as the ZANLA supported by Mao and the ZIPRA backed by the USSR. <br><br>- Forces are asymmetrical, as even if the Rhodesian are few in numbers, they are the only ones to have an air force and their special units are excellent. <br><br>- The Rebels are quite numerous and all around Rhodesia, extending the number of front lines, but their power is rather limited.<br><br>The population morale level is essential as if it falls too low, the Rhodesian player loses the game.<br><br>The game event cards allow full replay ability thanks to the numerous various situations that their create on the diplomatic, military, political or economical fields.<br><br>Estimated Playtime: 2h00<br><br>Favored Side: none<br><br>Hardest to Play: none.","short_description":"Rhodesia 1972 is the story of the isolated white rule in Rhodesia, trying to establish a stable and lasting state against the black rebels supported by Communist powers. The Rebels will try to unbalance the white population's morale by infiltrating as many fighters group inside the borders as possible.","fullgame":{"appid":"341040","name":"Wars Across The World"},"supported_languages":"English, French, German, Spanish - Spain, Russian","header_image":"https:\/\/steamcdn-a.akamaihd.net\/steam\/apps\/574967\/header.jpg?t=1544890312","website":"http:\/\/www.waw-games.com\/","pc_requirements":{"minimum":"<strong>Minimum:<\/strong><br><ul class=\"bb_ul\"><li><strong>OS:<\/strong> Windows 7\/8<br><\/li><li><strong>Processor:<\/strong> 2.5 GHz Intel Dual Core<br><\/li><li><strong>Memory:<\/strong> 2 GB RAM<br><\/li><li><strong>Graphics:<\/strong> 512 MB NVIDIA GeForce 9600<\/li><\/ul>","recommended":"<strong>Recommended:<\/strong><br><ul class=\"bb_ul\"><li><strong>OS:<\/strong> Windows 7 or higher<br><\/li><li><strong>Processor:<\/strong> 2.5 GHz Intel Dual Core<br><\/li><li><strong>Memory:<\/strong> 4 GB RAM<br><\/li><li><strong>Graphics:<\/strong> 1024 MB DirectX 11 compatible<\/li><\/ul>"},"mac_requirements":{"minimum":"<strong>Minimum:<\/strong><br><ul class=\"bb_ul\"><li><strong>OS:<\/strong> 10.9 or higher<br><\/li><li><strong>Processor:<\/strong> 2.5 GHz Intel Dual Core<br><\/li><li><strong>Memory:<\/strong> 2 GB RAM<br><\/li><li><strong>Storage:<\/strong> 750 MB available space<\/li><\/ul>","recommended":"<strong>Recommended:<\/strong><br><ul class=\"bb_ul\"><li><strong>OS:<\/strong> 10.9 or higher<br><\/li><li><strong>Processor:<\/strong> 2.5 GHz Intel Dual Core<br><\/li><li><strong>Memory:<\/strong> 4 GB RAM<br><\/li><li><strong>Storage:<\/strong> 2 GB available space<\/li><\/ul>"},"linux_requirements":[],"developers":["Strategiae"],"publishers":["Plug In Digital"],"price_overview":{"currency":"EUR","initial":299,"final":299,"discount_percent":0,"initial_formatted":"","final_formatted":"2,99\u20ac"},"packages":[146464],"package_groups":[{"name":"default","title":"Buy Wars Across the World: Rhodesia 1972","description":"","selection_text":"Select a purchase option","save_text":"","display_type":0,"is_recurring_subscription":"false","subs":[{"packageid":146464,"percent_savings_text":"","percent_savings":0,"option_text":"Rhodesia1972 - 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{ "01_no": "381", "02_chapter_name": "இறைமாட்சி", "03_kural_text": "படைகுடி கூழமைச்சு நட்பர ணாறு\nமுடையா னரசரு ளேறு", "04_parimel": "அதிகாரம் 39. இறை மாட்சி [அஃதாவது அவன்றன் நற்குண நற்செய்கைகள் , உலக பாலர் உருவாய் நின்று உலகம் காத்தலின் , ' இறை ' என்றார் : 'திருவுடை மன்னரைக் காணின் திருமாலைக் கண்டேனே என்னும் , '(திருவாய் 4,4,8) - (திருவாய் 34,8) என்று பெரியாரும் பணித்தார்.] \tபடைகுடி கூழ் அமைச்சு நட்பு அரண் உடையான் - படையும் குடியும் கூழும் அமைச்சும் நட்பும் அரணும் என்று சொல்லப்பட்ட ஆறு அங்கங்களையும் உடையவன், அரசருள் ஏறு = அரசருள் ஏறு போல்வான். (ஈண்டுக் 'குடி' என்றது, அதனை உடைய நாட்டினை. கூழ் என்றது, அதற்கு ஏதுவாகிய பொருளை. அமைச்சு , நாடு, அரண், பொருள், படை , நட்பு என்பதே முறையாயினும் ஈண்டுச் செய்யுள் நோக்கிப் பிறழ வைத்தார். 'ஆறும்' உடையான் என்றதனால், அவற்றுள் ஒன்று இல்வழியும் அரசநீதி செல்லாது என்பது பெற்றாம்.\tவடநூலார் இவற்றிற்கு 'அங்கம்' எனப்பெயர்கொடுத்ததூஉம் அது நோக்கி. 'ஏறு' என்பது உபசார வழக்கு.இதனால் அரசற்கு அங்கமாவன இவை என்பதூஉம், இவைமுற்றும் உடைமையே அவன் வெற்றிற்கு ஏது என்பதூஉம்கூறப்பட்டன.)", "05_muva": "படை குடி கூழ் அமைச்சு நட்பு அரண் என்று கூறப்படும் ஆறு அங்கங்களையும் உடையவனே அரசருள் ஆண் சிங்கம் போன்றவன்.", "06_manakudavar": "படையும் குடியும் கூழும் அமைச்சும் நட்பும் அரணுமென்னும் ஆறுபொருளினையும் உடையவன் அரசருள் ஏறுபோல்வன். ஈண்டுக் குடியுள் நாடு அடங்கிற்று. இஃது அரசனுக்கு உண்டாக்குவன கூறிற்று.", "07_devaneyar": "படை குடி கூழ் அமைச்சு நட்பு அரண் ஆறும் உடையான்-படையுங் குடியும் பொருளும் அமைச்சும் நட்பும் அரணும் என்று சொல்லப்பட்ட ஆறுறுப்புக்களையு முடையவன் ;அரசருள் ஏறு - அரசருள் ஆணரிமா போல்வான். நாடில்லாமற் குடியிருக்க முடியாதாகலின், இங்குக் குடியென்றது நாட்டையுஞ் சேர்த்தென அறிக. ஆகவே, இங்குக் கூறப்பட்ட வுறுப்புக்கள் உண்மையில் ஏழாம். அதனால் நாடு என்பது ஒரு தனியுறுப்பாக 74-ஆம் அதிகாரத்திற் கூறப்பட்டிருத் தலுங் காண்க. (நாடு) குடி, பொருள், படை, அரண், அமைச்சு, நட்பு என்பதே இயற்கை முறையாயினும், செய்யுளமைப்புநோக்கி மாற்றிக் கூறப்பட்டன. 'ஆறும்' என்னும் முற்றும்மையால், அவற்றுள் ஒன்று குறையினும் அக்காலத் தரசியல் நீடித்துச் செல்லாதென்பதாம். கூழ் என்பது உணவு. அது இங்கு அதற்கு மூலமான பொருளை யுணர்த்திற்று. ஏறு போல்வானை ஏறென்றது உவமையாகுபெயர். சில விலங்கின ஆண்பாற் பொதுப்பெயரான ஏறென்பது சிறப்புப்பற்றி அரிமாவின் ஏற்றைக்குறித்தது. ஏழுறுப்புமுள்ளவனைப் பகை யரசன் பெரும்பாலும் வெல்லமுடியா தென்பது கருத்து.", "08_gupope": "An army, people wealth, a minister, friends, fort; six things- Who owns them all , a lion lives amid the kings.", "09_yogi": "People, troops, wealth, forts, council, friends Who owns these six is lion of kings.", "10_kalaignar": "ஆற்றல்மிகு படை, அறிவார்ந்த குடிமக்கள், குறையா வளம், குறையற்ற அமைச்சு, முரிபடாத நட்பு, மோதியழிக்க முடியாத அரண் ஆகிய ஆறு சிறப்புகளும் உடையதே அரசுகளுக்கிடையே ஆண் சிங்கம் போன்ற அரசாகும்." }
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You will get to contribute fundamentally to the direction of the product and strategy of the business, as part of the senior management team.\nYou must have strong analytical and troubleshooting skills, fluency in coding, good communication skills, and most of all enthusiasm for tackling the challenges of balancing the business benefits of rapid development with safeguarding the stability of the service. And everything your team builds keeps the end user experience in mind. In the short term, you will be hands-on, resolving data reconciliation issues arising as well as problem shooting and back-end development in PHP (30% of time). \n\nYou will have responsibility for all technical aspects and technological resources of the business including budget control and the recruitment of additional development personnel, whom you will lead. \nThis role is especially suited to someone who wants to be part of the senior management team and influence the direction of the company.\n\n*Upcoming projects*\nMachine learning for automation of processes in fraud detection and claims\nVR/AR opportunity with our next insurance line \nRefactoring to support mutiple insurance lines\n\n*Tech stack*\nPHP (Symfony3), Javascript, MongoDB, AWS, HTML5 & CSS3\n\t\n\n*Experience*\nLeadership\nLed the technological strategy/architecture to meet the business needs as it expands across insurance lines and new geographies\nRecruiting and leading development teams \nManaging competing priorities and not hesitating to seek direction from Head of Product\n \n\nTechnical\nLaunching new products, APIs and working with partnerships\nLed a team of at least 5 people\nPayment knowledge \nUnderstand the constraints of regulation and GDPR\nOpen source frameworks\nFocus on testing whether unit or functional\nWorked with no SQL database\n\n*Must have*\nExperience: at least 10 years work experience.\nStartup: led the tech team in a startup at Series A stage\nAnalytical: deep analytical skills developed with top tier strategy consultancies, with a focus on insurance\nHands-on: ready to roll-up sleeves and get things done when needed.\nDevelopment: PHP Symfony experience\nLeadership: you should be able to motivate a group of committed, smart people to consistently deliver their best work, while doing the best work of your career. \nOrganisation: fantastical organisational skills and ability to prioritise\n \n*Our Culture*\nOur first tenet is ‘do the right thing for the customer’ , the second is ‘do the right thing for your team member’. We have a collaborative and supportive culture. While we work hard as in any startup, we provide a competitive package and flexible working hours, and we will give you the tools and support you so you can be the best.", "descriptionHtml": "<p>We are looking for an enthusiastic and hands on VP Engineering , who will lead our tech team in scaling our business across new products and geographies.</p>\n\n<p>You will be reporting to the CEO and leading a team of 5 developers (1 front end, 2 back end, 2 apps), but will not hesitate to get involved where needed from code-level support to safeguarding the availability of our service, thus ensuring security of database and dataflow with different value chain partners and designing the software infrastructure for growth. </p>\n\n<p>You will be comfortable deciding on architecture as well as managing an effective development and deployment process and understand the value of testing. You will get to contribute fundamentally to the direction of the product and strategy of the business, as part of the senior management team.<br>\nYou must have strong analytical and troubleshooting skills, fluency in coding, good communication skills, and most of all enthusiasm for tackling the challenges of balancing the business benefits of rapid development with safeguarding the stability of the service. And everything your team builds keeps the end user experience in mind. In the short term, you will be hands-on, resolving data reconciliation issues arising as well as problem shooting and back-end development in PHP (30% of time). </p>\n\n<p>You will have responsibility for all technical aspects and technological resources of the business including budget control and the recruitment of additional development personnel, whom you will lead. <br>\nThis role is especially suited to someone who wants to be part of the senior management team and influence the direction of the company.</p>\n\n<p><em>Upcoming projects</em><br>\nMachine learning for automation of processes in fraud detection and claims<br>\nVR/AR opportunity with our next insurance line <br>\nRefactoring to support mutiple insurance lines</p>\n\n<p><em>Tech stack</em><br>\nPHP (Symfony3), Javascript, MongoDB, AWS, HTML5 &amp; CSS3</p>\n\n<p><em>Experience</em><br>\nLeadership<br>\nLed the technological strategy/architecture to meet the business needs as it expands across insurance lines and new geographies<br>\nRecruiting and leading development teams <br>\nManaging competing priorities and not hesitating to seek direction from Head of Product</p>\n\n<p>Technical<br>\nLaunching new products, APIs and working with partnerships<br>\nLed a team of at least 5 people<br>\nPayment knowledge <br>\nUnderstand the constraints of regulation and GDPR<br>\nOpen source frameworks<br>\nFocus on testing whether unit or functional<br>\nWorked with no SQL database</p>\n\n<p><em>Must have</em><br>\nExperience: at least 10 years work experience.<br>\nStartup: led the tech team in a startup at Series A stage<br>\nAnalytical: deep analytical skills developed with top tier strategy consultancies, with a focus on insurance<br>\nHands-on: ready to roll-up sleeves and get things done when needed.<br>\nDevelopment: PHP Symfony experience<br>\nLeadership: you should be able to motivate a group of committed, smart people to consistently deliver their best work, while doing the best work of your career. <br>\nOrganisation: fantastical organisational skills and ability to prioritise</p>\n\n<p><em>Our Culture</em><br>\nOur first tenet is ‘do the right thing for the customer’ , the second is ‘do the right thing for your team member’. We have a collaborative and supportive culture. While we work hard as in any startup, we provide a competitive package and flexible working hours, and we will give you the tools and support you so you can be the best.</p>\n", "position": "full-time", "experience": 10, "visaSponsorship": false, "locations": [ "London" ], "remote": false, "remoteLocations": [], "skills": [ "PHP", "Javascript", "MongoDB", "Leadership", "Full Stack Development", "AWS" ], "payment": { "salary": "£60k – £80k", "equity": "0.0% – 1.0%" }, "recruiter": { "title": "CEO", "role": "Founder", "url": "https://angel.co/u/dylan-bourguignon", "name": "Dylan Bourguignon", "avatar": "https://photos.angel.co/users/1225344-medium_jpg?1500115173" }, "refs": { "angelListId": "519184", "angelListUrl": "https://angel.co/company/so-sure/jobs/519184-" } }, { "role": "Marketing", "title": "Head of Growth", "description": "so-sure is a tech start up on a mission to disrupt the greedy and untrustworthy insurance industry.\n \nThe first vertical so-sure is tackling, is mobile phone insurance and we are going to soon be expanding lines into home insurance. \n \nWe are looking for a Head of Growth. This role is in our growing team of 12 in our London office (Aldgate East), this role reports into the CEO. \n\n\nRole\nYou will own the paid performance of the business, balancing the need for growth with the need for effectiveness, especially in CPA. You will provide a relentless focus on metrics and data driven decision making, combined with a killer marketing instinct and gut-feel that makes you a success. Together with the senior management team, you will also be involved in guiding the wider performance of so-sure, helping to shape the direction of the business as it goes through the next stage of its growth. A series-A investment round, expansion into a new geography and a new insurance consumer line (home/contents) to be launched in the latter half of the year.\n\nYour experience will be current and forward thinking including success-tracking of marketing strategies, marketing communications, particularly in a referral based program, development and implementation of initiatives for lead generation and conversion within a CRM, public relations activities plus working with product management. You will also coordinate with the other functions of the organisation at strategic and tactical levels, the main one being customer service, and credibility building.\n\nYou are to be aware of the Company’s turnover and P&L targets and be aware of how the individual P&Ls feed into this.\n\nResponsibilities\nManaging all paid media activity and budget allocation across paid search, SEO, paid social and other channels\nDriving growth through organic channels\nDefining channel strategies and managing a continuous, meticulously planned and documented testing plan with an focus on measurement and analysis\nDelivering consistent channel growth and performance improvements, against key metrics and company targets\nDevising messaging to resonate with customer emotions\nForecasting and deep diving into channel performance, process and operations to identify opportunities and constantly optimise spend and ROI\nDeveloping segmentation and personalisation strategies based on customer profiling, purchase cycle and churn analysis\nLeading a team digital performance agencies\nBuilding the performance marketing infrastructure, such as reporting, process necessary to support growth\nManage and drive the customer service team with the customer service manager\nOwn the marketing budget\n\n\nRequirements\nWorked in a B2C digital startup, ideally from seed through a VC-backed series A round and beyond\nA proven Performance Marketer, deeply familiar with best practice and performance management of marketing channels\n7 years+ of digital marketing experience, highly effective communicator able to clearly present complex and data rich proposals, both in written and verbal form - happy to present to the board and other stakeholders on a regular basis\nFamiliar with traditional digital marketing tools (e.g. Google Ads, Google Analytics, Facebook Ads, Funnel analytics tools, Mixpanel) \nGood excel abilities and comfortability with business intelligence tools, ability to develop formulas and build reports with a meticulous attention to detail\nPrevious experience managing a team but ready to be sleeves rolled up\nCustomer service experience a bonus\nPrior use of Hubspot and Intercom will be advantageous\n\nAbout you\nTop notch organisational skills and proven ability to manage an agenda of projects and initiatives in a fast paced environment.\nEnjoy a challenge with a can do attitude; if something needs to happen, you find a way\nProactive with willingness to roll up sleeves and hunger to learn and develop\nAgility to understand the trade-offs between perfection and ‘good-enough’\nStrong interpersonal communication skills; you have to be able to communicate with, educate and get along with the team and outside the team.\n\nRECRUITMENT AGENCES PLEASE ABSTAIN.", "descriptionHtml": "<p>so-sure is a tech start up on a mission to disrupt the greedy and untrustworthy insurance industry.</p>\n\n<p>The first vertical so-sure is tackling, is mobile phone insurance and we are going to soon be expanding lines into home insurance. </p>\n\n<p>We are looking for a Head of Growth. This role is in our growing team of 12 in our London office (Aldgate East), this role reports into the CEO. </p>\n\n<p>Role<br>\nYou will own the paid performance of the business, balancing the need for growth with the need for effectiveness, especially in CPA. You will provide a relentless focus on metrics and data driven decision making, combined with a killer marketing instinct and gut-feel that makes you a success. Together with the senior management team, you will also be involved in guiding the wider performance of so-sure, helping to shape the direction of the business as it goes through the next stage of its growth. A series-A investment round, expansion into a new geography and a new insurance consumer line (home/contents) to be launched in the latter half of the year.</p>\n\n<p>Your experience will be current and forward thinking including success-tracking of marketing strategies, marketing communications, particularly in a referral based program, development and implementation of initiatives for lead generation and conversion within a CRM, public relations activities plus working with product management. You will also coordinate with the other functions of the organisation at strategic and tactical levels, the main one being customer service, and credibility building.</p>\n\n<p>You are to be aware of the Company’s turnover and P&amp;L targets and be aware of how the individual P&amp;Ls feed into this.</p>\n\n<p>Responsibilities<br>\nManaging all paid media activity and budget allocation across paid search, SEO, paid social and other channels<br>\nDriving growth through organic channels<br>\nDefining channel strategies and managing a continuous, meticulously planned and documented testing plan with an focus on measurement and analysis<br>\nDelivering consistent channel growth and performance improvements, against key metrics and company targets<br>\nDevising messaging to resonate with customer emotions<br>\nForecasting and deep diving into channel performance, process and operations to identify opportunities and constantly optimise spend and ROI<br>\nDeveloping segmentation and personalisation strategies based on customer profiling, purchase cycle and churn analysis<br>\nLeading a team digital performance agencies<br>\nBuilding the performance marketing infrastructure, such as reporting, process necessary to support growth<br>\nManage and drive the customer service team with the customer service manager<br>\nOwn the marketing budget</p>\n\n<p>Requirements<br>\nWorked in a B2C digital startup, ideally from seed through a VC-backed series A round and beyond<br>\nA proven Performance Marketer, deeply familiar with best practice and performance management of marketing channels<br>\n7 years+ of digital marketing experience, highly effective communicator able to clearly present complex and data rich proposals, both in written and verbal form - happy to present to the board and other stakeholders on a regular basis<br>\nFamiliar with traditional digital marketing tools (e.g. Google Ads, Google Analytics, Facebook Ads, Funnel analytics tools, Mixpanel) <br>\nGood excel abilities and comfortability with business intelligence tools, ability to develop formulas and build reports with a meticulous attention to detail<br>\nPrevious experience managing a team but ready to be sleeves rolled up<br>\nCustomer service experience a bonus<br>\nPrior use of Hubspot and Intercom will be advantageous</p>\n\n<p>About you<br>\nTop notch organisational skills and proven ability to manage an agenda of projects and initiatives in a fast paced environment.<br>\nEnjoy a challenge with a can do attitude; if something needs to happen, you find a way<br>\nProactive with willingness to roll up sleeves and hunger to learn and develop<br>\nAgility to understand the trade-offs between perfection and ‘good-enough’<br>\nStrong interpersonal communication skills; you have to be able to communicate with, educate and get along with the team and outside the team.</p>\n\n<p>RECRUITMENT AGENCES PLEASE ABSTAIN.</p>\n", "position": "full-time", "experience": 10, "visaSponsorship": false, "locations": [ "London" ], "remote": false, "remoteLocations": [], "skills": [ "Marketing Strategy", "Growth Hacking", "Growth Marketing" ], "payment": { "salary": "£65k – £85k", "equity": "% – 0.5%" }, "recruiter": { "title": "CEO", "role": "Founder", "url": "https://angel.co/u/dylan-bourguignon", "name": "Dylan Bourguignon", "avatar": "https://photos.angel.co/users/1225344-medium_jpg?1500115173" }, "refs": { "angelListId": "537930", "angelListUrl": "https://angel.co/company/so-sure/jobs/537930-" } }, { "role": "Software Engineer", "title": "Junior Backend Developer", "description": "Application Closing Date: 13/04/2020\r\n\r\nRequired experience:\r\n* Degree in Computer Science or equivalent qualification\r\n* Minimum 1 year NodeJS\r\n* Minimum 1 year Symfony &amp; Doctrine\r\n* MongoDB\r\n* MySQL\r\n* Linux servers\r\n* AWS Dev Ops (EC2, RDS, Aurora, CredStash, Auto Scaling Groups, Route53, CloudFront, Lambda, S3)\r\n* Strong understanding of microservice architecture\r\n* Terraform\r\n* Ansible\r\n* PHP - Symfony/Doctrine\r\n\r\nBonus experience but not required:\r\n* Multi-lingual\r\n* Adaptive to working on a Windows, Mac or Linux development environment\r\n* Docker\r\n* Vagrant\r\n\r\nYou’ll be working within a small tech team at an InsureTech startup based in central London. We are a phone insurance company aiming at providing a premium phone insurance service, boasting a 72 hour turnaround time for phone replacement.\r\n\r\nOur typical day operates from 9am - 6pm with a friendly and sociable atmosphere. In return, we require workers to be at the best of their game alongside a highly dynamic and well-disciplined team of developers maximizing output.\r\n\r\nResponsibilities:\r\n* Supporting and maintaining the legacy system\r\n* Reimplementing existing features in a microservice environment\r\n* Development of new features including, but not limited to; claims, monthly financial reconciliation, report generating, AB tests\r\n* Technical support for the customer support department", "descriptionHtml": "<p>Application Closing Date: 13/04/2020</p>\n\n<p>Required experience:</p>\n\n<ul>\n<li>Degree in Computer Science or equivalent qualification</li>\n<li>Minimum 1 year NodeJS</li>\n<li>Minimum 1 year Symfony &amp; Doctrine</li>\n<li>MongoDB</li>\n<li>MySQL</li>\n<li>Linux servers</li>\n<li>AWS Dev Ops (EC2, RDS, Aurora, CredStash, Auto Scaling Groups, Route53, CloudFront, Lambda, S3)</li>\n<li>Strong understanding of microservice architecture</li>\n<li>Terraform</li>\n<li>Ansible</li>\n<li>PHP - Symfony/Doctrine</li>\n</ul>\n\n<p>Bonus experience but not required:</p>\n\n<ul>\n<li>Multi-lingual</li>\n<li>Adaptive to working on a Windows, Mac or Linux development environment</li>\n<li>Docker</li>\n<li>Vagrant</li>\n</ul>\n\n<p>You’ll be working within a small tech team at an InsureTech startup based in central London. We are a phone insurance company aiming at providing a premium phone insurance service, boasting a 72 hour turnaround time for phone replacement.</p>\n\n<p>Our typical day operates from 9am - 6pm with a friendly and sociable atmosphere. In return, we require workers to be at the best of their game alongside a highly dynamic and well-disciplined team of developers maximizing output.</p>\n\n<p>Responsibilities:</p>\n\n<ul>\n<li>Supporting and maintaining the legacy system</li>\n<li>Reimplementing existing features in a microservice environment</li>\n<li>Development of new features including, but not limited to; claims, monthly financial reconciliation, report generating, AB tests</li>\n<li>Technical support for the customer support department</li>\n</ul>\n", "position": "full-time", "experience": 1, "visaSponsorship": false, "locations": [ "London" ], "remote": false, "remoteLocations": [], "skills": [], "payment": { "salary": "£28k – £28k", "equity": "No equity" }, "recruiter": { "title": null, "role": "Employee", "url": "https://angel.co/u/elliot-mitchell-6", "name": "Elliot Mitchell", "avatar": "https://angel.co/images/shared/nopic.png" }, "refs": { "angelListId": "757412", "angelListUrl": "https://angel.co/company/so-sure/jobs/757412-" } } ] }
{"title":"The Seven-Ups (Philip D'Antoni, 1973) [RePoPo] DVDRIP","uid":4154413,"size":1464457362,"categoryP":"video","categoryS":"movies","magnet":"?xt=urn:btih:b0390bb2fe52f6304c90c94ef160ab0f079a9b84&amp;dn=The+Seven-Ups+%28Philip+D%5C%27Antoni%2C+1973%29+%5BRePoPo%5D+DVDRIP&amp;tr=udp%3A%2F%2Ftracker.openbittorrent.com%3A80&amp;tr=udp%3A%2F%2Fopen.demonii.com%3A1337&amp;tr=udp%3A%2F%2Ftracker.coppersurfer.tk%3A6969&amp;tr=udp%3A%2F%2Fexodus.desync.com%3A6969","seeders":1,"leechers":0,"uploader":"repopo","files":4,"time":1209083978,"description":"*******************************************************************************\n The Seven-Ups (Philip D&amp;#039;Antoni, 1973)\n*******************************************************************************\n\n-------------------------------------------------------------------------------\n General Information\n-------------------------------------------------------------------------------\nType.................: Movie\nFile Validation......: SFV\nContainer File.......: Matroska\nVideo Format.........: H.263\nVideo Bitrate........: 1890\nAudio Format.........: AC3\nAudio Languages......: English 2.0\nSubtitles Enclosed...: English-Spanish\nResolution...........: 704x384\nColor................: 24 bit\nFPS..................: 23.976\nSource...............: DVD 16x9\nDuration.............: 01:43:18\nOriginal Format......: NTSC\nGenre................: Thriller\nIMDb Rating..........: 6.5\nMovie Information....: http://www.imdb.com/title/tt0070672/\n\n-------------------------------------------------------------------------------\n Release Info\n-------------------------------------------------------------------------------\nNew York City cops wage a war against assorted hoods and criminals after one of \ntheir own is brutally killed by a hoodlum. Seven-Ups refers to the minimum jail \ntime each of the crooks will have to spend if they are caught. Written by \nPatrick Knightly {&lt;a class=&quot;__cf_email__&quot; href=&quot;/cdn-cgi/l/email-protection&quot; data-cfemail=&quot;cfbfa5a4a1a6a8a7bb8fbfa0a3bcaca6e1baa2aebcbce1aaabba&quot;&gt;[email&amp;#160;protected]&lt;/a&gt;&lt;script cf-hash='f9e31' type=&quot;text/javascript&quot;&gt;\n/* &lt;![CDATA[ */!function(){try{var t=&quot;currentScript&quot;in document?document.currentScript:function(){for(var t=document.getElementsByTagName(&quot;script&quot;),e=t.length;e--;)if(t[e].getAttribute(&quot;cf-hash&quot;))return t[e]}();if(t&amp;&amp;t.previousSibling){var e,r,n,i,c=t.previousSibling,a=c.getAttribute(&quot;data-cfemail&quot;);if(a){for(e=&quot;&quot;,r=parseInt(a.substr(0,2),16),n=2;a.length-n;n+=2)i=parseInt(a.substr(n,2),16)^r,e+=String.fromCharCode(i);e=document.createTextNode(e),c.parentNode.replaceChild(e,c)}}}catch(u){}}();/* ]]&gt; */&lt;/script&gt;}\n\nThe seven-ups are a secret, elite New York detective squad who are very \neffective in catching criminals, even if their tactics are questionable. \nHowever, what one of the detectives doesn&amp;#039;t know is that one of his informants \nis mastermind of a plot to kidnap loan sharks. The kidnappers get to their \nvictims by impersonating police officers. While investigating one of the \ndisappearances, one of the seven-ups gets spotted and is killed. The situation \nputs the seven-ups in a precarious position because it looks like they are tied \nto the kidnappings. So now one detective has to find the murderers and clear the \nseven-ups&amp;#039; soiled reputation. Written by &lt;a class=&quot;__cf_email__&quot; href=&quot;/cdn-cgi/l/email-protection&quot; data-cfemail=&quot;5339342360666660132a323b3c3c7d303c3e&quot;&gt;[email&amp;#160;protected]&lt;/a&gt;&lt;script cf-hash='f9e31' type=&quot;text/javascript&quot;&gt;\n/* &lt;![CDATA[ */!function(){try{var t=&quot;currentScript&quot;in document?document.currentScript:function(){for(var t=document.getElementsByTagName(&quot;script&quot;),e=t.length;e--;)if(t[e].getAttribute(&quot;cf-hash&quot;))return t[e]}();if(t&amp;&amp;t.previousSibling){var e,r,n,i,c=t.previousSibling,a=c.getAttribute(&quot;data-cfemail&quot;);if(a){for(e=&quot;&quot;,r=parseInt(a.substr(0,2),16),n=2;a.length-n;n+=2)i=parseInt(a.substr(n,2),16)^r,e+=String.fromCharCode(i);e=document.createTextNode(e),c.parentNode.replaceChild(e,c)}}}catch(u){}}();/* ]]&gt; */&lt;/script&gt;\n\nA sting takes place at an antique store that is a front for laundering \ncounterfeit money. It is the latest success of The Seven-Ups, a squad of \nundercover NY policemen whose collars regularly get sentences of seven years or \nup. Two mobsters are presently in the squad&amp;#039;s sights - Max Kalish, a \nbusinessman, and Festa, a bail bondsman. However, Buddy Manuchi, the Seven-Ups&amp;#039; \nleader, gets wind of strange and violent happenings within the mob, unaware that \nMax Kalish was kidnapped and held until payment of a huge ransom, and now he and \nother mobsters are in panic mode. Things then go from bad to worse for both The \nSeven-Ups and Kalish&amp;#039;s mob when one the the squad&amp;#039;s members is found out and \ntied up in a car trunk, only to see the real kidnappers grab Cotello, one of \nKalish&amp;#039;s partners, and blast him and the helpless undercover cop. When Buddy \narrives on the scene, the real killers flee, and a mad car chase through the \nstreets of New York blasts onto the country freeway and ends in a savage crash \ninto the underside of a crippled 18-wheeler. The Seven-Ups now probe to find out \nwho is kidnapping mobsters to find the killers of their partner, and Buddy \nsuddenly realizes they have a police mole working for them. Written by Michael \nDaly.\n\n-------------------------------------------------------------------------------\n Personal Info\n-------------------------------------------------------------------------------\nMy releases so far... personal rips from original DVDs, looking for quality.\n\nWhenever there&amp;#039;s an AC3 file, there&amp;#039;s 99% possibilities this is the directly\nripped audio track from the DVD, untouched.\n\nThey&amp;#039;re usually uploaded in TPB, Mininova and Demonoid, but feel free to share \nthem on edonkey networks or in any way you want. Spread the word.\n\nI recommend you to use VLC Media Player for a correct reproduction of matroska files.\n\n- Timerider: The Adventure of Lyle Swann (DVDRip Dual Spanish-English) (1,4Gb)\n AVI/MP3, Dual English-Spanish, no subs\n\n- The Yakuza (Sidney Pollack, 1974) (DVDRip Dual Eng-Esp) (1,3Gb)\n AVI/AC3, Dual English-Spanish, subpack including multiple subtitles\n\n- Dracula&amp;#039;s Daughter (Lambert Hillyer, 1936, DUal-Multisubs) (700Mb)\n H264/AAC in Matroska container, Dual Eng-ESP, subs ENG-ESP-ITA-POR\n\n- Dracula (George Melford, 1931, Spanish Audio) (1,4Gb)\n H264/AC3 in Matroska container, ESP audio, subs ENG-ESP-ITA-POR-CRO\n\n- Queen Christina (Rouben Mamoulian, 1933, Dual-Multisubs) (1,45Gb)\n H.264/AC3/AAC in Matroska container, ENG-ESP Audio and subs, also enclosed a \n subpack with multiple subs\n\n- Poltergeist (25th anniversary-WideScreen) (Tobe Hooper, 1982) (Dual Multisubs)\n H.264/AC3 in Matroska container, ENG-ESP Audio and subs, also enclosed a \n subpack with multiple subs\n\n- The Spy Who Came In From The Cold (Martin Ritt, 1965) (Dual Multisubs)\n H.264/AAC in Matroska container, Eng-Esp audio and subs, also enclosed a \n subpack with multiple subs\n\n- Someone Behind The Door (Nicolas Gessner, 1971) (Dual MultiSubs)\n H.264/AC3 in Matroska container, Eng-Esp audio and Subs, also enclosed a \n subpack with multiple subs\n\n- The Mark Of Zorro (Rouben Mamoulian, 1933) (Dual Eng-Esp)\n H.264/AC3 in Matroska container, Eng-Esp audio and Subs. Spanish dub is \n LATIN SPANISH\n\n- Knife In The Water (N�z w wodzie) (Roman Polanski, 1962) (Polish-Spanish)\n H.264/AC3. Original Polish audio and spanish dub. Subbed in english and \n spanish.\n\n- Alien (Virtual Workprint) FANEDIT (Ridley Scott, 1979)\n H.264/AAC. Audio in English 2.0. No subs.\n\n- Brazil (The Love Conquers All Version) (Terry Gilliam, 1985)\n H.264/AC3. Audio in English 2.0. No subs.\n\n- The Seven-Ups (Philip D&amp;#039;Antoni, 1973)\n H.264/AC3. Audio in English 2.0. 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{"brief_title": "Replagal Enzyme Replacement Therapy for Children With Fabry Disease", "brief_summary": "Primary Objective(s): - To assess the safety of Replagal at a dose of 0.2 mg/kg administered over 40 (+/-10) minutes in children with Fabry disease - To assess the effect of Replagal on heart rate variability in patients 7 to 17 years of age Secondary Objective(s): - To determine the pharmacokinetics of Replagal at baseline and after the initiation of enzyme replacement therapy (ERT) - To determine exploratory measurements of efficacy including renal function (ie, estimated glomerular filtration rate [eGFR] and creatinine clearance), clinical outcomes (in Cohorts 1 and 2), and sweating and left ventricular mass index (LVMI) (Cohort 1, Phase 1 only)", "detailed_description": "TKT029 is an open label multi-center study to assess the safety of enzyme replacement therapy with Replagal (agalsidase alfa) in children with Fabry disease, who have completed 6 months of agalsidase alfa therapy in study TKT023 (Cohort 1) or who are treatment-na\u00efve (Cohort 2) and meet all inclusion/exclusion criteria of this study. The study will consist of every other week treatment with Replagal for 52 weeks, with periodic reassessments by Shire HGT for continuation of the study beyond 52 weeks. A decision on the part of the study sponsor to terminate the study may be made at any time. In Cohort 1, safety and clinical measurement assessments performed during Week 25 or 26 of Study TKT023 served as the baseline assessments for TKT029. Patients in Cohort 1 began treatment with Replagal manufactured using a roller bottle process (Replagal RB); this portion of treatment is denoted as Cohort 1, Phase 1. Safety evaluation visits for Cohort 1, Phase 1 were to be performed at Weeks 13, 25, 55, and every 26 weeks thereafter until the patient discontinued from the study or transitioned to treatment with Replagal manufactured using a bioreactor process (Replagal AF). The transition to Replagal AF marked the restart of the study clock and was denoted as Cohort 1, Phase 2. Safety evaluation visits for Cohort 1, Phase 2 will be performed at Weeks 1, 13, 25, 55, and every 26 weeks thereafter until the patient discontinues from or the sponsor terminates the study. Patients in Cohort 2 will receive treatment with Replagal AF only; therefore there is only 1 study phase for these patients. Screening assessments performed at Week -1 will serve as the baseline assessments for this study. Safety evaluation visits for Cohort 2 will be performed at Weeks 13, 25, 37, 55 and every 26 weeks thereafter until the patients discontinues from or the sponsor terminates the study. The final study visit for both cohorts will follow 30 days after the study study drug infusion, at which time a final safety evaluation will be performed. Patients who complete the study will be interviewed by telephone 30 days after their last study infusion for resolution of any outstanding adverse events (AEs) or concomitant medication changes. Any patient who withdraws early from the study will have a final study visit 30 days after the last study drug infusion, at which time a final safety evaluation will be performed.", "condition": ["Fabry Disease"], "intervention_type": ["Drug"], "intervention_name": ["Agalsidase alfa"], "description": ["0.2 mg/kg agalsidase alfa administered by IV infusion over 40 (+/- 10) minutes every other week for 52 weeks, with periodic reassessments for study continuation beyond 52 weeks"], "arm_group_label": ["Agalsidase alfa (Cohort 1)", "Agalsidase Alfa (Cohort 2)"], "other_name": ["Replagal"], "criteria": "Inclusion Criteria: 1a. For Cohort 1 (both phases): - Patients must have completed all study requirements and assessments for Study TKT023 less than 30 (+/-7) days prior to enrolling in Study TKT029 and must have no safety or medical issues that contraindicate participation. OR 1b. For Cohort 2: - The patient is between 7 and 17 years of age at the time of informed consent, inclusive. - The patient must be ERT-naive. - The patient is a hemizygous male with Fabry disease as confirmed by a deficiency of alpha-galactosidase A activity measured in serum, leukocytes, or fibroblasts. Male patients who do not already have a documented deficiency of alpha-galactosidase A activity will provide a blood sample during screening for determination of alpha-galactosidase A activity level in their serum. OR - The patient is a heterozygous female or hemizygous male with Fabry disease as confirmed by a mutation of the alpha-galactosidase A gene. Patients who do not already have a documented mutation of the alpha-galactosidase A gene will provide a blood sample during screening for genotyping. 2. Adequate general health (as determined by the Investigators) to undergo the specified phlebotomy regimen and protocol-related procedures and no safety or medical contraindications for participation. 3. The minor child must assent to participate in the protocol and the parent(s) or legally authorized guardian(s) must have voluntarily signed an Institutional Review Board/Independent Ethics Committee (IRB/IEC) approved informed concent form after all relevant aspects of the study have been explained and discussed with the child and the child's parent(s) or legal guardian(s). Exclusion Criteria: Patients who meet any of the following criteria are not eligible for this study: - Patient and/or the patient's parent(s) or legal guardian(s) are unable to understand the nature, scope, and possible consequences of the study. - Patient is unable to comply with the protocol, e.g., uncooperative with protocol schedule, refusal to agree to all of the study procedures, inability to return for safety evaluations, or is otherwise unlikely to complete the study, as determined by the Investigator or the medical monitor.", "gender": "All", "minimum_age": "7 Years", "maximum_age": "17 Years", "healthy_volunteers": "No", "keyword": "Pediatrics", "mesh_term": ["Fabry Disease"], "id": "NCT00084084"}
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{ "problems":[ { "avgPts":189.17, "constraints":[], "correctRatio":71.45, "definition":[], "div":0, "examples":[], "level":1, "link":"http://community.topcoder.com/stat?c=problem_statement&pm=9760&rd=12177", "name":"RelativePath", "notes":[], "submission":627 }, { "avgPts":263.68, "constraints":[], "correctRatio":28.47, "definition":[], "div":0, "examples":[], "level":2, "link":"http://community.topcoder.com/stat?c=problem_statement&pm=9764&rd=12177", "name":"AllCycleLengths", "notes":[], "submission":288 }, { "avgPts":507.73, "constraints":[], "correctRatio":5.26, "definition":[], "div":0, "examples":[], "level":3, "link":"http://community.topcoder.com/stat?c=problem_statement&pm=9744&rd=12177", "name":"ReasonableOdds", "notes":[], "submission":57 } ], "name":"Single Round Match 405 > Round 1", "link":"http://community.topcoder.com/stat?c=round_overview&er=5&rd=12177" }
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{"cacheTime": 1595373010, "baseUrl": "https://kater.me/d/76704", "title": "幹 醉了啦", "content": [{"author": "小黑犬宇嚎狺嗷", "body": "\n<p>\n 真的醉,但我的羅傑星系德很\n <br/>\n 你看我這文打的很正確\n </p>\n"}, {"author": "鉀金屬色調色盤", "body": "\n<p>\n 羅傑星系德很…\n </p>\n"}, {"author": "閻天尤人", "body": "\n<p>\n 嘿寶貝。\n </p>\n"}, {"author": "棉被單", "body": "\n<p>\n 羅傑星系德德德傑星傑星羅傑\n </p>\n"}, {"author": "青霧島響", "body": "\n<p>\n 這個厲害了嗷嗷\n </p>\n"}, {"author": "別再打了我不會認錯的", "body": "\n<p>\n 這不太德羅傑\n </p>\n"}, {"author": "小黑犬宇嚎狺嗷", "body": "\n<p>\n<a href=\"https://i.imgur.com/WmdXonD.jpg\" rel=\"nofollow noreferrer\" target=\"_blank\">\n<img alt=\"\" src=\"https://i.imgur.com/WmdXonD.jpg\" title=\"\"/>\n</a>\n</p>\n"}, {"author": "鉀金屬色調色盤", "body": "\n<p>\n 德\n </p>\n"}]}
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{"success":true,"result":{"Q_10106712692430-2":{"resources":[],"questions":[{"id":"Q_10106712692430-2","subjectId":101,"knowledgePoints":null,"knowledgePointsNew":[],"testMethods":[{"id":"TM_10100000673226","main":1}],"solutionMethods":[],"resourceIds":null,"resourceIndex":0,"listenUrl":null,"listenName":null,"listenSeconds":0,"exploreSeconds":0,"answersSeconds":0,"paperIds":["P_10100076786734-2"],"books":null,"booksNew":null,"contentTypeId":1010008,"contentType2Id":0,"difficultyInt":3,"description":"阅读课外短文,回答下列问题","notFitMobile":0,"seconds":720,"complex":1,"nid":null,"lastEditorId":null,"finalAuditorId":null,"roughAuditorIds":null,"content":{"content":"<p style=\"text-align: center;\"><strong>把钱退回去</strong></p><p style=\"text-indent: 2em;\"><span style=\"text-indent: 2em;\">彭总担任国防部长期间,曾多次出国访问。每次出国,他都很节俭,从不多花一分钱。他经常对身边的工作人员说:“过去,我们节约每一个铜板,是为了革命战争;今天,我们节约每一分钱,是为了国家的经济建设。” </span></p><p style=\"text-indent: 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{"brief":"tear out","long":"Meaning: to \"tear out\". Usage: break. Source: for \"H5422\"; "}
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{"Sacramento": {"California State Fair": "The California State Fair is the annual state fair for the state of California. The fair is held at Cal Expo in Sacramento, California.\n\n\n== History ==\nAccording to an editorial in the Daily Alta on November 5, 1850, fairs were common on the east coast of the United States."}}
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In case your magic works, you can create this magic wherever you want.\nSupporting existing content from the brief stage through execution and advertisement by using a huge range of marketing tools. \n\nQualifications:\n• Bachelor's degree or equivalent practical experience\n• Content Marketing experience\n• Fluent English writing skills\n• Open minded\n• Positive thinking\n\nEmail your CV to denis(at)nlsql.com\n\nBy applying for this position please share 1 example of your English text post on Reddit, Quora, Medium, Facebook, Twitter, LinkedIn, etc.", "descriptionHtml": "<p>Do you believe humans are able to interact with database or ERP system by using only natural language? <br>\nAre you ready for the challenges nobody had before?</p>\n\n<p>If both abovementioned questions YES, that&#39;s position for you:</p>\n\n<p>Content Marketing Manager will be responsible for developing magic content. <br>\nThis magic is measured by increasing website traffic, registrations and inbound leads as main KPIs for this position. 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{"brief_title": "COL-3 in Treating Patients With Progressive or Recurrent Brain Tumors", "brief_summary": "RATIONALE: COL-3 may stop the growth of brain tumors by stopping blood flow to the tumor. PURPOSE: Phase I/II trial to study the effectiveness of COL-3 in treating patients who have progressive or recurrent brain tumors following radiation therapy or chemotherapy.", "detailed_description": "OBJECTIVES: - Determine the maximum tolerated dose, dose limiting toxicity, and safety profile of oral COL-3 alone or when combined with anticonvulsants known to be metabolized by CYP450 in patients with progressive or recurrent high grade anaplastic astrocytoma, anaplastic oligodendroglioma, or glioblastoma multiforme. - Define the pharmacokinetics and pharmacodynamics of COL-3 on this schedule and determine the effects of hepatic enzyme inducing drugs, such as anticonvulsants, on the pharmacokinetics. - Determine the response rate, disease free survival, and survival in patients treated with this regimen. OUTLINE: This is a dose-escalation, multicenter study of COL-3. Patients are stratified by anticonvulsant (anticonvulsants that cause induction of CYP450 vs anticonvulsants that cause modest or no induction of CYP450 or no anticonvulsant). - Phase I: Patients receive oral COL-3 daily. Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of COL-3 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose limiting toxicity. - Phase II: Patients receive oral COL-3 daily at the MTD from the phase I portion of this study. Patients are followed every 2 months until death. PROJECTED ACCRUAL: A total of 15-18 patients will be accrued for phase I of the study and a total of 35 patients will be accrued for phase II of the study at a rate of 3 patients per month.", "condition": ["Brain and Central Nervous System Tumors"], "intervention_type": ["Drug"], "intervention_name": ["incyclinide"], "criteria": "DISEASE CHARACTERISTICS: - Histologically proven high grade glioma that is progressive or recurrent following radiotherapy or chemotherapy - Anaplastic astrocytoma - Anaplastic oligodendroglioma - Glioblastoma multiforme - Prior low grade glioma that has progressed to high grade glioma following radiotherapy and/or chemotherapy allowed - Measurable disease by MRI or CT scan PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - Karnofsky 60-100% Life expectancy: - Not specified Hematopoietic: - Absolute neutrophil count at least 1,500/mm^3 - Platelet count at least 100,000/mm^3 Hepatic: - Bilirubin normal - SGOT or SGPT no greater than 2.5 times upper limit of normal Renal: - Creatinine no greater than 1.5 mg/dL OR - Creatinine clearance greater than 60 mL/min Cardiovascular: - No myocardial infarction, stroke, or congestive heart failure within the past 3 months Other: - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception during and for 1 month after study - No serious active infection or medical illness that would preclude compliance - HIV negative - No history of gastrointestinal disorders that would interfere with absorption of study drug - No other malignancy within the past 5 years except curatively treated carcinoma in situ of the cervix or breast, or basal cell or squamous cell skin cancer - No hypersensitivity to tetracyclines or its derivatives PRIOR CONCURRENT THERAPY: Biologic therapy: - No concurrent filgrastim (G-CSF) Chemotherapy: - At least 4 weeks since prior chemotherapy (6 weeks since prior nitrosoureas) and recovered - No more than 2 prior chemotherapy regimens Endocrine therapy: - Not specified Radiotherapy: - No prior large field radiotherapy (greater than 20% of total bone marrow) - At least 3 months since other prior radiotherapy and recovered Surgery: - No prior major upper gastrointestinal surgery - At least 14 days since other prior major surgery Other: - No other concurrent investigational agents - No prolonged sun exposure", "gender": "All", "minimum_age": "18 Years", "maximum_age": "N/A", "healthy_volunteers": "No", "keyword": "adult gliosarcoma", "mesh_term": ["Nervous System Neoplasms", "Central Nervous System Neoplasms"], "id": "NCT00004147"}
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