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PMC10000501 | Multisystem Inflammatory Syndrome in Adults Associated with Recent Infection with COVID-19 | Diagnostics | 2023-03-04 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000501/ | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( | Multisystem inflammatory syndrome in adults (MIS-A) is an uncommon but severe and still understudied post-infectious complication of COVID-19. Clinically, the disease manifests itself most often 2–6 weeks after overcoming the infection. Young and middle-aged patients are especially affected. The clinical picture of the... | Multisystem inflammatory syndrome was first described as a nosological entity in 2020, initially mainly in a group of pediatric patients (as MIS-C). Later, the first cases of this disease also began to appear in a group of adult patients (MIS-A). In adults, the clinical course is extremely variable, with primarily febr... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Multisystem inflammatory syndrome was first described as a nosological entity in 2020, initially mainly in a group of pediatric patients (as MIS-C). Later, the first cases of this disease also began to appear in a group of adult pati... | Multisystem inflammatory syndrome was first described as a nosological entity in 2020, initially mainly in a group of pediatric patients (as MIS-C). Later, the first cases of this disease also began to appear in a group of adult patients (MIS-A). In adults, the clinical course is extremely variable, with primarily febr... | A 22-year-old patient, who was not treated for anything prior to testing, was examined at the outpatient department of the infectious disease clinic for fever lasting 3 days with a maximum temperature of up to 40.2 °C, as well as myalgia, arthralgia, headache, a dry cough with dyspnea, and vomiting. The patient reporte... | Multisystem inflammatory syndrome represents a potentially life-threatening complication upon infection with COVID-19, the pathophysiology of which is not yet fully understood. The syndrome was first described in April 2020 in a group of children whose clinical symptoms resembled Kawasaki disease. Later, similar cases ... | Multisystem inflammatory syndrome in adults represents a severe complication of COVID-19, whose pathophysiology has not yet been clarified. It likely arises from the dysregulated immune response of the host caused by the SARS-CoV-2 virus. It most often occurs in the postacute period of infection, and the clinical manif... | ||||||
PMC10003745 | Body Stalk Anomaly Complicated by Ectopia Cordis: First-Trimester Diagnosis of Two Cases Using 2- and 3-Dimensional Sonography | Journal of Clinical Medicine | 2023-02-27 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003745/ | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( | Introduction: Body stalk anomaly is a severe defect of the abdominal wall, characterized by the evisceration of abdominal organs and, in more severe cases, thoracic organs as well. The most serious condition in a body stalk anomaly may be complicated by ectopia cordis, an abnormal location of the heart outside the thor... | Body stalk anomaly is a congenital abnormality of the abdominal wall, depending on the evisceration of abdominal organs and, in more complicated clinical cases, thoracic organs. This anomaly is usually characterized also by kyphoscoliosis and by a defect of the umbilical cord, which is usually short or not present . Th... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Body stalk anomaly is a congenital abnormality of the abdominal wall, depending on the evisceration of abdominal organs and, in more complicated clinical cases, thoracic organs. This anomaly is usually characterized also by kyphoscol... | Body stalk anomaly is a congenital abnormality of the abdominal wall, depending on the evisceration of abdominal organs and, in more complicated clinical cases, thoracic organs. This anomaly is usually characterized also by kyphoscoliosis and by a defect of the umbilical cord, which is usually short or not present . Th... | A 25-year-old woman was referred for an ultrasound scan at 9 weeks of gestation.
There was no relevant medical history, and she was taking no medication. There were no teratogenic risk factors in the clinical history of the woman. It was her second pregnancy, and her first pregnancy was uneventful. The ultrasound scan... | In our scientific work, we described our experience with two cases of prenatal diagnosis of a body stalk anomaly complicated by ectopia cordis during a routine sonographic screening for chromosomic abnormalities in the first trimester. A body stalk anomaly is defined as a pathological congenital condition of multiple a... | Body stalk anomaly is a congenital pathological condition with uncertain etiopathogenesis, uncertain pathophysiology, and an uncertain incidence rate. In the scientific literature, most of the reported clinical cases described an early diagnosis performed between 10 and 14 weeks of gestation; in our first case report, ... | ||||||
PMC10006300 | Primary intramuscular and intermuscular Echinococcal disease of the iliopsoas and sartorius muscles: A case report | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006300/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Hydatid disease is a parasitic infection caused by the Echinococcus tapeworm. Classically, Echinococcal lesions are slowly growing cystic masses with daughter cysts. The most common sites of disease are the liver in 75% of cases and lungs in 15% of cases. This report covers a case of a patient from Southeast Europe wit... | Hydatid disease is a parasitic disease caused by the Echinococcus tapeworm. The most common species are Echinococcus granulosis and Echinococcus multilocularis, where they are endemic to South America, Central Europe, the Mediterranean, Central Asia, Western China, and East Africa . Classically, hydatid lesions are slo... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Hydatid disease is a parasitic disease caused by the Echinococcus tapeworm. The most common species are Echinococcus granulosis and Echinococcus multilocularis, where they are endemic to South America, Central Europe, the Mediterranean,... | Hydatid disease is a parasitic disease caused by the Echinococcus tapeworm. The most common species are Echinococcus granulosis and Echinococcus multilocularis, where they are endemic to South America, Central Europe, the Mediterranean, Central Asia, Western China, and East Africa . Classically, hydatid lesions are slo... | A 60-year-old male with a history of poliomyelitis as a child and residual right-sided weakness presented initially to his primary care physician for left lower quadrant abdominal pain, a left groin painful mass, and left lower extremity swelling. The patient grew up in Montenegro and moved to the United States as a te... | Hydatid disease is a parasitic infection caused by ingestion of the Echinococcus tapeworm larva. The most common species are Echinococcus granulosus, which causes cystic hydatid disease, and E multilocularis, which causes alveolar hydatid disease. The definitive host is usually a dog where the adult worm lives in the p... | Informed consent was obtained from the subject described in this report. | ||||||
PMC10006302 | Hydrosalpinx with adnexal torsion in an adult patient–A case report | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006302/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Adnexal torsion is a common gynecological emergency and a significant cause of acute pelvic pain in women. Hydrosalpinx-induced torsion of the adnexa is a rare situation and requires prompt and accurate management. Twenty-three years old nulliparous woman admitted in our structure for acute pelvic pain. The ultrasound ... | Adnexal torsion usually involves both the ovary and fallopian tube, but can involve only one of them in some cases .
Hydrosalpinx is a rare predisposing factor of adnexal or isolated fallopian tube torsion. Infection causes damage to the endosalpinx, resulting in a distal occlusion of the tube and accumulation of the ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Adnexal torsion usually involves both the ovary and fallopian tube, but can involve only one of them in some cases .\n\nHydrosalpinx is a rare predisposing factor of adnexal or isolated fallopian tube torsion. Infection causes damage to... | Adnexal torsion usually involves both the ovary and fallopian tube, but can involve only one of them in some cases .
Hydrosalpinx is a rare predisposing factor of adnexal or isolated fallopian tube torsion. Infection causes damage to the endosalpinx, resulting in a distal occlusion of the tube and accumulation of the ... | Twenty-three years old nulliparous woman, without history of illness or drug use, admitted to the Gynecology Emergency Department for sudden-onset, intense, acute pelvic pain, which had started 2 hours before the admission.
Firstly, anamnesis revealed that the patient had similar but much less severe episodes in the p... | Hydrosalpinx occurs following a complete distal occlusion due to tubal damage and adhesions caused by various conditions of the fimbriated end of the tube .
In adults, the most common cause of hydrosalpinx is pelvic inflammatory disease.
Hydrosalpinx is one of the predisposing factors of adnexal torsion. Any increase... | Hydrosalpinx-induced adnexal torsion is a rare gynecological emergency. Clinical presentation is nonspecific and is often difficult to distinguish from other acute abdominal conditions.
Early diagnosis is important for preventing necrosis of the twisted adnexa. Multiplanar MR imaging may be used to help differentiate ... | ZE is the corresponding author, she participated in the organization and writing of the article and studying the cases with YC. Professor NE, MH, BA and YL supervised working and validated the figures. YB and FM contributed in clinical examination, surgical treatment and follow up of the patient. Professor and chief of... | |||||
PMC10006724 | Pancreatic involvement in Erdheim-Chester disease: Rare presentation of a rare disease | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006724/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Erdheim-Chester disease (ECD) as a rare non-Langerhans histiocytosis has various clinical manifestations. It is characterized histologically by infiltration of every organ, more commonly bone, retroperitoneum, cardiovascular and CNS systems with foamy, lipid -laden macrophage. Pancreatic involvement as a manifestation ... | Erdheim-Chester disease (ECD) is a rare, potentially fatal systemic myeloid neoplastic disease, first described as” lipid granulomatosis” by Jakob Erdheim and William Chester (1930) . It is characterized histologically by tissue infiltration of lipid-laden, monoclonal CD68+CD1a− non-Langerhans cell histiocytes, chronic... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Erdheim-Chester disease (ECD) is a rare, potentially fatal systemic myeloid neoplastic disease, first described as” lipid granulomatosis” by Jakob Erdheim and William Chester (1930) . It is characterized histologically by tissue infiltr... | Erdheim-Chester disease (ECD) is a rare, potentially fatal systemic myeloid neoplastic disease, first described as” lipid granulomatosis” by Jakob Erdheim and William Chester (1930) . It is characterized histologically by tissue infiltration of lipid-laden, monoclonal CD68+CD1a− non-Langerhans cell histiocytes, chronic... | A 73-year-old lady was evaluated at our hospital because of a recently detected infiltrative middle mediastinal lesion on chest CT scan, shortness of breath and fatigue.
The patient had been in her usual state of health until 1 year before this evaluation, when she was seen at the emergency department (ED) for sudden ... | The etiology of ECD still remains unclear. It is classified as a neoplastic disease due to recently discovered monoclonal proliferation of the myeloid cells in various organs . A proposed mechanism is maladaptive activation of a proinflammatory program (with no known infection etiology) in monocytes/-macrophages throug... | Erdheim-Chester has been known as a disease of long bones and retroperitoneum, However, it potentially affects all organs. Here we described the third case of pancreatic Erdheim-Chester to the best of our knowledge with imaging findings on CT scan, MRI, and 18FDG-PET along with extensive cardiovascular, CNS and bone in... | Bone pain, most commonly around the knees and ankles is the most frequent presenting manifestation of skeletal involvement . However, 60% of patients are asymptomatic and the disease may be only detected on Imaging studies .
Bilateral and symmetric cortical thickening and sclerosis of the diaphysis and metaphysis of t... | |||||
PMC10008222 | Kaposi sarcoma at the base of the tongue in a renal transplant patient | BMJ Case Reports | 2023-01-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008222/ | This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cit... | Oral Kaposi Sarcoma (OKS) commonly occurs in patients with AIDS. The incidence of Kaposi sarcoma (KS) is greatly increased in renal transplant recipients compared with the general population, with particular prevalence in certain ethnic groups where it can occur in up to 5% of transplant recipients. From them, only 2% ... | Kaposi sarcoma (KS) is an angioproliferative disease that is rare in the general population. The incidence is 0.01%–0.06% with a male-to-female ratio of 3:1, mainly affecting individuals of Mediterranean, Jewish and Arab ancestry.1 However, the rates of KS increase up to 500-fold in solid organ transplant recipients on... | [
{
"section_type": "background",
"heading": "Background",
"text": "Kaposi sarcoma (KS) is an angioproliferative disease that is rare in the general population. The incidence is 0.01%–0.06% with a male-to-female ratio of 3:1, mainly affecting individuals of Mediterranean, Jewish and Arab ancestry.1 Howeve... | Kaposi sarcoma (KS) is an angioproliferative disease that is rare in the general population. The incidence is 0.01%–0.06% with a male-to-female ratio of 3:1, mainly affecting individuals of Mediterranean, Jewish and Arab ancestry.1 However, the rates of KS increase up to 500-fold in solid organ transplant recipients on... | A man in his early 40s was admitted to the hospital after reporting a lump in his throat for the previous 2 weeks. He had been transplanted with a live-donor kidney 2 years prior due to focal segmental glomerulosclerosis (FSGS) related to uncontrolled type 1 diabetes mellitus (T1DM), which the patient developed in his ... | Blood analysis including complete blood count and blood chemistry was done. In addition, the following procedures were performed.
Cervical ultrasound.Biopsy from the lesion at the base of the tongue.Biopsy of the cervical lymph node.Immunohistochemical test.MRI.PET-CT. | Treatment with the calcineurin inhibitor was stopped, and the patient started with an mTOR (mammalian target of rapamycin) inhibitor and continued with a corticosteroid.
During the first 2 weeks after beginning with mTOR inhibitors, the patient received 10 courses of radiotherapy to the base of the tongue. As a compli... | Clinically, KS strongly resembles certain vascular lesions, including haemangiomas, lymphangiomas, arteriovenous malformation, ecchymosis, low-grade mucoepidermoid carcinoma and bacillary angiomatosis. It may resemble pyogenic granuloma or peripheral giant cell proliferation when present on the alveolar ridge.3
From t... | Two months following radiotherapy, the tracheostomy was removed. A fibreoptic examination revealed no traces of the disease in the base of the tongue or nasopharynx. Moreover, a second PET-CT was performed, and a complete remission of the disease was documented. The patient still had one solitary lymph node in the left... | ||||
PMC10009334 | Acute cervicitis resembling gastric-type mucinous adenocarcinoma that was definitively diagnosed by cervical conization: A case report | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009334/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Although imaging studies are not typically performed for clinical diagnosis of cervicitis, in this case magnetic resonance imaging (MRI) was performed because a lesion with a tumor-like gross appearance was found in the uterine cervix. We present a case of cervicitis in which clinical, imaging and pathological features... | Uterine cervicitis, known as the initial manifestation of sexually transmitted diseases (STDs), is a common disease encountered in gynecological clinical practice, and its symptoms include abnormal vaginal discharge with or without genital bleeding . Magnetic resonance imaging (MRI) is rarely performed for workup becau... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Uterine cervicitis, known as the initial manifestation of sexually transmitted diseases (STDs), is a common disease encountered in gynecological clinical practice, and its symptoms include abnormal vaginal discharge with or without geni... | Uterine cervicitis, known as the initial manifestation of sexually transmitted diseases (STDs), is a common disease encountered in gynecological clinical practice, and its symptoms include abnormal vaginal discharge with or without genital bleeding . Magnetic resonance imaging (MRI) is rarely performed for workup becau... | The patient, a 30-year-old woman (gravida [G] 2, para [P] 2), was referred to a gynecologist with a complaint of watery vaginal discharge. On visual examination, the uterine cervix was irregularly enlarged and bled easily. Cervical cancer was suspected, but cervical cytology performed at the same time was negative. The... | Uterine cervical infection is defined as invasion of cervical tissue by a microorganism or virus with or without tissue injury. Cervicitis is often asymptomatic, but watery discharge, pelvic pressure or postcoital bleeding may occur. It is diagnosed by symptoms and clinical findings such as mucopurulent endocervical ex... | |||||||
PMC10009337 | Solitary juvenile xanthogranuloma in the parotid gland | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009337/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Juvenile xanthogranuloma (JX) is a non-Langerhans cell histiocytosis. Although precipitating factors remain unclear, it has been described mainly in infancy and early childhood. The giant variant of JX is a rare form that presents in infancy, measures over 2 cm and tends to involute only partly. Herein, we report a ver... | Juvenile xanthogranuloma (JX) is the most common non-Langerhans cell histiocytosis and occurs in infants and young children . It is a benign proliferative lesion that arises mainly from dermal dendrocytes. Predisposing stimuli that have been described involve infectious agents, such as cytomegalovirus infection or phys... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Juvenile xanthogranuloma (JX) is the most common non-Langerhans cell histiocytosis and occurs in infants and young children . It is a benign proliferative lesion that arises mainly from dermal dendrocytes. Predisposing stimuli that have... | Juvenile xanthogranuloma (JX) is the most common non-Langerhans cell histiocytosis and occurs in infants and young children . It is a benign proliferative lesion that arises mainly from dermal dendrocytes. Predisposing stimuli that have been described involve infectious agents, such as cytomegalovirus infection or phys... | An otherwise healthy 1 month old girl presented with a firm, palpable mass located anterior-inferior to the right external auditory canal, over the right parotid gland. The lesion did not seem to adhere to either bone or muscular structure and no cutaneous lesion was detected. The baby was part of a dichorionic twin pr... | JX is an uncommon lesion caused by proliferation of histiocytes, of the non-Langerhans type. It is usually benign and occurs as single or multiple, mainly skin lesions, exhibiting either a systemic component or not. Deep-seated, bone and visceral lesions also exist, associated or not with cutaneous manifestations . The... | The authors declare and confirm that written, informed consent for publication of our patients’ case was obtained from the legal guardian of our patient. | ||||||
PMC10010120 | A Rare Case of COVID-19-Induced Acute Exacerbation of Oral Dermatitis Herpetiformis in a Geriatric Patient | International Medical Case Reports Journal | 2023-03-09 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010120/ | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at | Introduction Dermatitis herpetiformis (DH) is an autoimmune vesiculobullous disease associated with celiac enteropathy. The clinical manifestation of DH is the occurrence of a papulovesicular rash on the skin. Oral mucosal involvement in DH is very rare. This study aimed to describe the impact of COVID-19 on the acute ... | Dermatitis herpetiformis (DH) is an autoimmune vesiculobullous disease that was first proposed by Louis Dühring in 1884. DH is a chronic and recurrent disease caused by hypersensitivity to gluten. The predisposing factor for DH is genetic involving Human Leukocyte Antigens (HLAs) DQ2 and DQ8. DH can occur at any age, b... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Dermatitis herpetiformis (DH) is an autoimmune vesiculobullous disease that was first proposed by Louis Dühring in 1884. DH is a chronic and recurrent disease caused by hypersensitivity to gluten. The predisposing factor for DH is genet... | Dermatitis herpetiformis (DH) is an autoimmune vesiculobullous disease that was first proposed by Louis Dühring in 1884. DH is a chronic and recurrent disease caused by hypersensitivity to gluten. The predisposing factor for DH is genetic involving Human Leukocyte Antigens (HLAs) DQ2 and DQ8. DH can occur at any age, b... | A 74-year-old woman was referred from the Department of Dermatology and Venereology to the Department of Oral Medicine Dr. Hasan Sadikin Hospital, Bandung. The patient has been hospitalized for 4 days and has been given dexamethasone 5 mg intravenously, cetirizine 10 mg tablets, and clindamycin tablets 300 mg. Based on... | Dermatitis herpetiformis (DH) is a mucocutaneous manifestation of celiac disease (CD), in which the gluten triggers an itchy, blistering rash in genetically susceptible individuals. The etiology of DH is multifactorial with strong genetic and autoimmune influences.10 The pathophysiology of DH involves a complex set of ... | In this case report, COVID-19 infection can trigger an acute exacerbation of dermatitis herpetiformis. SARS-CoV-2 causes an immune dysregulation and induces hypersensitivity reaction. Dentists can collaborate with other departments in diagnosing and treating oral lesions related to dermatitis herpetiformis. | ||||||
PMC10010791 | Autoimmune Enteropathy: A Rare Cause of Chronic Diarrhea in an Adult Patient | ACG Case Reports Journal | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010791/ | This is an open access article distributed under the terms of the | ABSTRACT Autoimmune enteropathy is a rare cause of malabsorption usually associated with circulating autoantibodies and predisposition to autoimmune disorders. The diagnosis is based on the following criteria: chronic diarrhea (>6 months), malabsorption, specific histological findings, anti-enterocyte and anti-goblet c... | Autoimmune enteropathy (AIE) is a rare cause of intractable diarrhea associated with villous atrophy of the small bowel, lack of response to dietary exclusion, and autoimmunity predisposition.1,2 Although the diagnosis is more frequent in children, its prevalence is increasing in adults.3 Symptoms are unspecific and ca... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Autoimmune enteropathy (AIE) is a rare cause of intractable diarrhea associated with villous atrophy of the small bowel, lack of response to dietary exclusion, and autoimmunity predisposition.1,2 Although the diagnosis is more frequent ... | Autoimmune enteropathy (AIE) is a rare cause of intractable diarrhea associated with villous atrophy of the small bowel, lack of response to dietary exclusion, and autoimmunity predisposition.1,2 Although the diagnosis is more frequent in children, its prevalence is increasing in adults.3 Symptoms are unspecific and ca... | A 73-year-old woman with type 2 diabetes under metformin was admitted to the emergency department with severe nonbloody diarrhea for the past 5 months and a weight loss of 18 kg (20% of body weight). Physical examination was unremarkable, except for signs of severe weight loss. She denied relevant medical history or ot... | AIE is a rare disorder characterized by intractable diarrhea and small intestine mucosal atrophy resulting from immune-mediated injury.2 Typically, patients are unresponsive to dietary modifications, including a gluten-free diet.1,4 Although it is primarily a pediatric disease, it is now well recognized to occur in adu... | Author contributions: AC Carvalho drafted the manuscript, performed a review of the literature, and is the article guarantor. J. Pinho was responsible for data acquisition and the concept and design of the study. E. Cancela and A. Silva critically revised the report.
Financial disclosure: None to report.
Informed con... | ||||||
PMC10010827 | Uncommon presentation of a giant psoas muscle lipoma: a case report and brief literature review | Annals of Medicine and Surgery | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010827/ | This is an open access article distributed under the terms of the | Giant retroperitoneal lipomas, particularly within the psoas muscle, are a rare condition. We herein present one such case of a 45-year-old Italian man and a literature review. There are only two case reports published in the literature, thus posing challenges for the appropriate diagnosis and treatment. Our patient wa... | Lipoma, defined as a benign proliferation and collection of adipocytes, is the most common soft tissue tumor in adults1. Although it has been linked to several risk factors, such as genetic abnormalities, posttraumatic events, obesity, liver disease, alcohol abuse, or glucose intolerance, the etiology remains still unc... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Lipoma, defined as a benign proliferation and collection of adipocytes, is the most common soft tissue tumor in adults1. Although it has been linked to several risk factors, such as genetic abnormalities, posttraumatic events, obesity, ... | Lipoma, defined as a benign proliferation and collection of adipocytes, is the most common soft tissue tumor in adults1. Although it has been linked to several risk factors, such as genetic abnormalities, posttraumatic events, obesity, liver disease, alcohol abuse, or glucose intolerance, the etiology remains still unc... | After completing the examinations and preoperative assessments, the patient underwent an exploratory laparotomy on November 2021. A bulky yellowish tumor was found to occupy the right retroperitoneum until the right iliac fossa, inside the left psoas major muscle. Our team at Veneto Institute of Oncology performed en b... | Psoas muscle lipomas are an uncommon lipoma subtype, given that only two articles have been published in the literature6,7.
As in our case, patients with retroperitoneal intramuscular lipomas most likely do not experience pain or symptoms for a long time until the mass shifts the adjacent soft tissues or peripheral ne... | In conclusion, a giant of the psoas muscle is a rare condition, given that this is the first report with such dimensions and, in general, there are only two case reports published in the literature. The appropriate diagnosis and treatment remain still challenging; hence alongside CT and MRI, a CT-guided FNAB should be ... | On 31 May 2021, a 45-year-old Italian man was admitted to the emergency department with acute colicky abdominal pain. He denied experiencing any nausea, loss of appetite, or even change in bowel habits or urinary frequency. The patient had no significant past medical history except right urolithiasis, and he was not on... | |||||
PMC10010871 | Confluent and Reticulated Papillomatosis Successfully Treated with Topical Vitamin A Derivative | Case Reports in Dermatological Medicine | 2023-01-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010871/ | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | Confluent and reticulated papillomatosis (CARP) is a rare dermatosis that typically develops in adolescents and young adults. Clinical characteristics include hyperkeratotic papules that coalesce centrally with a reticulated pattern peripherally on the central and upper trunk, neck, and axilla. Its etiology is not prec... | Confluent and reticulated papillomatosis (CARP) is a rare dermatosis originally described by Gougerot and Carteaud and also called Gougerot–Carteaud syndrome . It is characterized by hyperkeratotic or verrucous grey-brownish papules that coalesce into confluent plaques centrally with a reticulated pattern peripherally ... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Confluent and reticulated papillomatosis (CARP) is a rare dermatosis originally described by Gougerot and Carteaud and also called Gougerot–Carteaud syndrome . It is characterized by hyperkeratotic or verrucous grey-brownish papules ... | Confluent and reticulated papillomatosis (CARP) is a rare dermatosis originally described by Gougerot and Carteaud and also called Gougerot–Carteaud syndrome . It is characterized by hyperkeratotic or verrucous grey-brownish papules that coalesce into confluent plaques centrally with a reticulated pattern peripherally ... | A 17-year-old boy, otherwise healthy, presented with a new onset of asymptomatic, persistent, and slowly progressing brownish skin lesions over the trunk for 6 months. Past medical history, drug history, and family background were noncontributory. Examination revealed hyperpigmented, hyperkeratotic, confluent macules, ... | CARP is a rare skin disorder that preferentially affects young adults without particular sex predilection . Its pathogenesis is not precisely known, but there are various theories. It was thought to be caused by Malassezia furfur as CARP clinically resembles tinea versicolor. Still, studies have not been consistent wit... | CARP is an uncommon and curable dermatosis. The effectiveness of tretinoin in this patient supports the theory that CARP is a keratinization disorder. Initiation of treatment with topical tretinoin when there are no limitations on its use would be reasonable, as it can provide a safer alternative to systemic therapy. | ||||||
PMC10011048 | Generalized lichen spinulosus and secondary follicular mucinosis | JAAD Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011048/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Lichen spinulosus (LS) is a follicular keratotic disorder and a variant of keratosis pilaris. LS usually shows a localized distribution, but a rare, generalized variant exists in the setting of chronic diseases such as HIV and Crohn’s disease.1,2
Follicular mucinosis (FM) can occur in a primary idiopathic form, or as ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Lichen spinulosus (LS) is a follicular keratotic disorder and a variant of keratosis pilaris. LS usually shows a localized distribution, but a rare, generalized variant exists in the setting of chronic diseases such as HIV and Crohn’s d... | Lichen spinulosus (LS) is a follicular keratotic disorder and a variant of keratosis pilaris. LS usually shows a localized distribution, but a rare, generalized variant exists in the setting of chronic diseases such as HIV and Crohn’s disease.1,2
Follicular mucinosis (FM) can occur in a primary idiopathic form, or as ... | A 21-year-old female was referred with xerosis, generalized spiny skin lesions, and a provisional diagnosis of eczema that did not improve on a medium-strength topical corticosteroid. She did not report other medical ailments, medication, atopy, or allergies, and a personal or family history of similar skin lesions was... | In 1883, Crocker described a disorder he named “lichen pilaris seu spinulosus.” The currently accepted term is LS, and it predominantly occurs in the second decade of life.5
The aetiology of LS is unknown, but it has been postulated that there is a genetic predisposition or a follicular reaction pattern. The lesions a... | None disclosed. | |||||||
PMC10011052 | Pancoast tumor mimicking lung tuberculosis, a case report | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011052/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | It is well-recognized that tuberculosis (TB) can mimic several clinical diseases, particularly cancer. On several occasions, lung TB can be misdiagnosed as cancer, particularly in developed countries with a rare case of TB and high incidence of lung cancer, and vice versa— in which Indonesia, with a high incidence of T... | Diagnostic chameleon is what tuberculosis (TB) is known for due to its similar appearance and clinical manifestation to cancer , leading to occasional misdiagnosis ; it could be challenging to distinguish its radiological features apart from actual tumors . Pancoast syndrome refers to a series of clinical manifestation... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Diagnostic chameleon is what tuberculosis (TB) is known for due to its similar appearance and clinical manifestation to cancer , leading to occasional misdiagnosis ; it could be challenging to distinguish its radiological features apart... | Diagnostic chameleon is what tuberculosis (TB) is known for due to its similar appearance and clinical manifestation to cancer , leading to occasional misdiagnosis ; it could be challenging to distinguish its radiological features apart from actual tumors . Pancoast syndrome refers to a series of clinical manifestation... | A 59-year-old male was referred to our department from the pulmonology outpatient clinic with right upper chest pain and constitutional symptoms of chronic cough and weight loss. No history of TB treatment, diabetes, hypertension, malignancy, or shortness of breath was recalled, and no history of similar complaints amo... | TB, the so-called diagnostic chameleon, is well known for its characteristics mimicking cancer , resulting in occasional misdiagnosis . Clinical information and radiology findings of TB can be otherwise unspecific and equivalent to other illnesses, particularly tumors. These growths are referred to as pseudo-tumors. To... | All patients seeking medical attention deserve to be treated carefully, avoiding unnecessary diagnostic procedures which can result in a delay in definitive therapy. Although the patient presents with classic symptoms and radiology features, ruling out the differential diagnosis is of paramount importance. Definitive d... | M. Ikhsan Nugroho contributed to the writing of the manuscript. Anggraini Dwi Sensusiati contributed to diagnoses, data curation, and data organization. M. Ikhsan Nugroho and Anggraini Dwi Sensusiati contributed to the conceptualization of the manuscript. All authors have reviewed and approved the final manuscript.
Al... | |||||
PMC10011055 | Isolated pancreatic tuberculosis with splenic tuberculosis mimicking lymphoma malignum: A case report | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011055/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Tuberculosis is an endemic disease in certain parts of the world. This disease typically presents in the lungs, but it may also appear within the abdomen, such as in the pancreas. There can be challenges in diagnosing isolated pancreatic tuberculosis as it may mimic other diseases radiologically. We present a 33-year-o... | Tuberculosis is a common occurrence in certain endemic zones of Asia. Even though tuberculosis primarily affects the lungs, isolated abdominal tuberculosis may also be found with incidence ranging from 0.59% to 12% . The diagnosis of abdominal tuberculosis is challenging because of the disease's rarity and nonspecific ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Tuberculosis is a common occurrence in certain endemic zones of Asia. Even though tuberculosis primarily affects the lungs, isolated abdominal tuberculosis may also be found with incidence ranging from 0.59% to 12% . The diagnosis of ab... | Tuberculosis is a common occurrence in certain endemic zones of Asia. Even though tuberculosis primarily affects the lungs, isolated abdominal tuberculosis may also be found with incidence ranging from 0.59% to 12% . The diagnosis of abdominal tuberculosis is challenging because of the disease's rarity and nonspecific ... | A 33-year-old female was admitted to the hospital presenting a history of intermittent middle epigastric pain and having lost 4 kg in weight over 2 months. According to the patient's history, she had no coughing, fever, or jaundice. She had never received a bacillus Calmette–Guerin (BCG) vaccine and she had no history ... | Isolated pancreatic tuberculosis is a rare finding due to the antituberculous effect of pancreatic enzymes . Splenic tuberculosis is also a rare finding and usually occurs as a part of miliary tuberculosis . In this patient, we did not find any other organ involvement, so we were able to rule out a miliary tuberculosis... | The diagnosis of pancreatic and splenic tuberculosis is challenging due to its ability to mimic other neoplastic processes such as lymphoma malignum. A correct diagnosis of pancreatic and splenic tuberculosis may prevent unnecessary surgical procedures for the patient. | Written consent was obtained for the publication of the current case. No patient identifiers were disclosed.
The data used for this case report are available from the corresponding author upon reasonable request. | |||||
PMC10011681 | A giant superficial myofibroblastoma involving the vagina and pelvis: A case report and review of the literature | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011681/ | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Superficial myofibroblastoma is a rare benign mesenchymal tumor that presents a challenge in accurate preoperative diagnosis because of its overlapping radiological and histological features. A 27-year-old woman presented with a history of increasing abdominal girth over the prior year and pelvic mass for 1 month. Imag... | Superficial myofibroblastoma is a rare benign mesenchymal tumor that presents with a nodular or polypoid-like morphology in the lower genital tract in females; it occurs primarily in the vagina, rarely in the cervix, and occasionally in the vulva , , , , . The pathological differential diagnoses are other genital mesen... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Superficial myofibroblastoma is a rare benign mesenchymal tumor that presents with a nodular or polypoid-like morphology in the lower genital tract in females; it occurs primarily in the vagina, rarely in the cervix, and occasionally in... | Superficial myofibroblastoma is a rare benign mesenchymal tumor that presents with a nodular or polypoid-like morphology in the lower genital tract in females; it occurs primarily in the vagina, rarely in the cervix, and occasionally in the vulva , , , , . The pathological differential diagnoses are other genital mesen... | The pathogenesis of superficial myofibroblastoma is not well understood. The disease presents in women in the fifth through eighth decades of life . However, nearly one-third of patients have a history of tamoxifen or hormone-replacement therapy, suggesting that hormones may possibly have a role in the development of t... | To our knowledge, this is the first publicly reported case of a giant superficial vaginal myofibroblastoma involving both the pelvis and vagina. Due to overlapping radiological and histological features, making an accurate preoperative diagnosis of genital mesenchymal tumors is challenging. Imaging features and compreh... | A 27-year-old woman, G0P0, presented with a 1-year history of increasing abdominal girth and a 1-month history of a giant pelvic mass. Occasionally, a small amount of vaginal bleeding occurred in the first 2 days after the menstrual period. Vaginal discharge, prolonged menstrual cycles and increased menstrual volume di... | ||||||
PMC10011988 | Primary yolk sac tumor in the abdominal wall in a 20-year-old woman: A case report | World Journal of Clinical Cases | 2023-03-06 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011988/ | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commerciall... | BACKGROUND Extragonadal yolk sac tumors (YSTs) are rare, with only a low reported tumor occurrence outside the gonads locally and abroad. Extragonadal YSTs are usually a diagnostic challenge, because they are infrequent, but also because a thoughtful and detailed differential diagnostic process must be performed. CASE ... | Core Tip: Extragonadal yolk sac tumors (YSTs) are usually a diagnostic challenge, because they are infrequent, but also because a thoughtful and detailed differential diagnostic process must be performed. In this case, since the tumor presented classic yolk sac tumor features, and immunohistochemistry was concordant, t... | [
{
"section_type": "other",
"heading": "",
"text": "Core Tip: Extragonadal yolk sac tumors (YSTs) are usually a diagnostic challenge, because they are infrequent, but also because a thoughtful and detailed differential diagnostic process must be performed. In this case, since the tumor presented classic ... | Yolk sac tumor (YST), also known as endodermal sinus tumor or primitive endodermal tumor, is a rare and highly malignant tumor of germ cell origin. It is common in infant and adolescent children with a median age at diagnosis of 19 years, with 40% of patients diagnosed in the prepubertal period. This tumor occurs mostl... | Palpation revealed that the mass was located in the hypogastric region, with a size of about 5 cm × 3 cm, The lesion was well defined, was not capsulated, normal skin without redness or swelling, poor range of motion, and no tenderness. | The patient underwent subcutaneous tumor resection. The mass was found to be located in the deep layer of subcutaneous fat, and the entire mass was completely dissected and sent for biopsy. We found the cut surface of the tumor was greyish-red and greyish-yellow in colour, soft to medium in quality, with visible necros... | Based on the clinical information, histological features, and immunohistochemical staining profile described above, the tumor was diagnosed as a primary YST in the abdominal wall. YST is a common tumor in the gonads, especially in the ovary and testis, and is rarely found in regions other than the gonads, according to ... | Extragonadal YSTs are usually a diagnostic challenge, because they are infrequent, but also because a thoughtful and detailed differential diagnostic process must be performed. In this case, since the tumor presented classic YST features, and immunohistochemistry was concordant, the diagnostic process was more straight... | Core Tip: Extragonadal yolk sac tumors (YSTs) are usually a diagnostic challenge, because they are infrequent, but also because a thoughtful and detailed differential diagnostic process must be performed. In this case, since the tumor presented classic yolk sac tumor features, and immunohistochemistry was concordant, t... | ||||
PMC10013409 | Gastric squamous metaplasia observed by image‐enhanced endoscopy | DEN Open | 2023-03-14 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013409/ | This is an open access article under the terms of the | Abstract A 61‐year‐old Helicobacter pylori ‐positive female with gastroesophageal reflux disease has undergone surveillance endoscopy every year for 13 years at Tokyo Medical University Hospital. At the first surveillance in 2009, conventional white light endoscopy showed a 10‐mm whitish slightly depressed lesion at th... | Metaplasia, including Barrett's esophagus in the esophagus and ectopic gastric mucosa in the esophagus and duodenum, is often observed in gastrointestinal endoscopy during routine health checks. Metaplasia generally involves the histological transformation of one differentiated cell type to another. For example, in Bar... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Metaplasia, including Barrett's esophagus in the esophagus and ectopic gastric mucosa in the esophagus and duodenum, is often observed in gastrointestinal endoscopy during routine health checks. Metaplasia generally involves the histolo... | Metaplasia, including Barrett's esophagus in the esophagus and ectopic gastric mucosa in the esophagus and duodenum, is often observed in gastrointestinal endoscopy during routine health checks. Metaplasia generally involves the histological transformation of one differentiated cell type to another. For example, in Bar... | A 74‐year‐old female with gastroesophageal reflux disease grade M and the reflux‐related symptom was given esomeprazole 20 mg for 13 years at Tokyo Medical University Hospital. During the 13‐year observational period, the patient received Helicobacter pylori eradication therapy seven times. However, despite administrat... | Here, we report an H. pylori‐positive patient with gastric squamous metaplasia in gastric cardia monitored using surveillance endoscopy for 13 years, in whom gastric squamous metaplasia was first evaluated by a combination of NBI and TXI.
According to previous studies, gastric squamous metaplasia appears as white or p... | The authors declare no conflict of interest.
Supplemental A case of esophageal squamous cell carcinoma (ESCC). ESCC observed by (A) white‐light imaging, (B) texture and color enhancement imaging mode 1, and (C) mode 2 1.Click here for additional data file. | ||||||
PMC10014146 | Spontaneous periduodenal hematoma: a rare surgical and radiological conundrum | Journal of Surgical Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014146/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( | Abstract This is a case of a 68-year-old female with spontaneous and rare periduodenal hematoma of unknown origin without any signs or symptoms of duodenal stenosis. All causes of known precipitating factors, such as trauma, intervention, anticoagulation, pancreatitis or malignant processes, were ruled out. She was man... | Periduodenal hematoma without precipitating trauma is a rare entity. Trauma, including various intervention-related injuries of the duodenum causing intramural or periduodenal hematoma has been presented multiple times in the literature. Spontaneous intramural hematoma is reported more frequently as a complication of a... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Periduodenal hematoma without precipitating trauma is a rare entity. Trauma, including various intervention-related injuries of the duodenum causing intramural or periduodenal hematoma has been presented multiple times in the literature... | Periduodenal hematoma without precipitating trauma is a rare entity. Trauma, including various intervention-related injuries of the duodenum causing intramural or periduodenal hematoma has been presented multiple times in the literature. Spontaneous intramural hematoma is reported more frequently as a complication of a... | A 68-year-old female presented to the emergency department with a 3-day history of severe epigastric pain radiating to the back and the right shoulder with associated nausea, without vomiting. She had no preceding trauma. Previous surgeries of total abdominal hysterectomy, bilateral oophorectomy were confined to the lo... | The first autopsy confirmed intramural intestinal hematoma published by James McLauchlan . In the early 1900s, there were several reported cases of intestinal hematoma, either caused by hemophilia and hemorrhagic purpura or reported trauma. The first preoperatively, radiologically described and diagnosed jejunal hemato... | None declared.
None.
The documents used during the current study are available from the corresponding author on reasonable request.
Informed consent was obtained from the patient for publication of this case report and accompanying figures. | ||||||
PMC10014514 | Mycophenolate mofetil–induced hyperlipidemia with cutaneous manifestations | Clinical Case Reports | 2023-03-14 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014514/ | This is an open access article under the terms of the | Abstract We report a case of a 49 year old woman who developed biopsy‐proven xanthomas on her hands and arms after initiation of Mycophenolate mofetil therapy for systemic lupus erythematosus (SLE) and subsequently went into remission upon cessation of the medication. | 1
Xanthomas are lipid deposits in the connective tissue of the skin, tendons, or fasciae that are predominantly composed of foam cells, which are macrophages that have excessively phagocytized recently oxidized low‐density lipoprotein cholesterol (LDL‐C) particles.
1
Clinically, they are expressed as yellow‐orange pa... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "1\n\nXanthomas are lipid deposits in the connective tissue of the skin, tendons, or fasciae that are predominantly composed of foam cells, which are macrophages that have excessively phagocytized recently oxidized low‐density lipoprotei... | 1
Xanthomas are lipid deposits in the connective tissue of the skin, tendons, or fasciae that are predominantly composed of foam cells, which are macrophages that have excessively phagocytized recently oxidized low‐density lipoprotein cholesterol (LDL‐C) particles.
1
Clinically, they are expressed as yellow‐orange pa... | 2
The patient is a 49‐year‐old female with a pertinent medical history of SLE who presented for evaluation of painful, non‐pruritic, oozing lesions on her hands and arms. The patient denied any history of prior, similar lesions and noted that they first started to develop within days of initiation of mycophenolate mof... | 3
A variety of medications have been associated with drug‐induced hyperlipidemia, including immunosuppressant drugs such as mycophenolate mofetil. The mechanism behind drug‐induced hypercholesterolemia has yet to be elucidated. Nuclear receptor pregnane X receptor (PXR; NR1I2), a ligand‐activated transcription factor ... | Rebecca M Yim: Conceptualization; writing – original draft; writing – review and editing. Vikram Sahni: Writing – original draft; writing – review and editing. Jason Mathis: Conceptualization; investigation; project administration; writing – review and editing.
None.
No conflicts of interest have been declared by the... | ||||||
PMC10014520 | Acquired hemophilia A in a patient with adult‐onset Still's disease: Successful treatment with steroids | Clinical Case Reports | 2023-03-14 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014520/ | This is an open access article under the terms of the | Abstract Acquired hemophilia A (AHA) is a potentially life‐threatening hemorrhagic disorder with many etiologies. We report the first case in the literature describing the association of AHA with adult‐onset Still's disease (AOSD). | 1
Acquired hemophilia A (AHA) is a rare hemostatic disorder mediated by autoantibodies against endogenous factor VIII (FVIII) which typically interfere with its procoagulant function. It is a potentially fatal disease affecting patients without any previous history of bleeding. Therefore, its diagnosis must be suspect... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "1\n\nAcquired hemophilia A (AHA) is a rare hemostatic disorder mediated by autoantibodies against endogenous factor VIII (FVIII) which typically interfere with its procoagulant function. It is a potentially fatal disease affecting patie... | 1
Acquired hemophilia A (AHA) is a rare hemostatic disorder mediated by autoantibodies against endogenous factor VIII (FVIII) which typically interfere with its procoagulant function. It is a potentially fatal disease affecting patients without any previous history of bleeding. Therefore, its diagnosis must be suspect... | 2
A 25‐year‐old Tunisian woman was referred to our internal medicine department in January 2006, due to prolonged fever, generalized fatigue, and polyarthralgia with arthritis involving the large and the small joints, which began 3 weeks before presentation. She also manifested a transient maculopapular rash occurring... | 3
We have described an original observation of AHA associated to AOSD.
AHA occurs with an incidence of approximately 1.5 cases per million each year and represents predominantly a pathology of the elderly (median age of onset range: 64–78 years).
4
,
5
,
6
A small peak age in the incidence was reported in women, r... | 4
To our knowledge, AHA associated with AOSD has never been described. The purpose of this observation is to highlight the importance of a rapid diagnosis of such a rare disease, often misdiagnosed or even unrecognized. This is not only important for a better understanding of the pathogenesis of the diseases, but also... | Chifa Damak: Resources. Donia Chebbi: Conceptualization; resources; writing – original draft. Faten Frikha: Resources. Ikram El Ahmer: Conceptualization; resources; writing – original draft. imen krichen: Resources; supervision; validation. Choumous Kallel: Resources; supervision; validation. Mouna Snoussi: Resources. ... | |||||
PMC10014979 | Mitral Valve Endocarditis in Patient Awaiting TAVI: A Case
Report | Clinical Medicine Insights. Case Reports | 2023-03-13 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014979/ | This article is distributed under the terms of the Creative Commons
Attribution-NonCommercial 4.0 License ( | Background: The current literature focuses on the risk of infective endocarditis (IE)
following transcatheter aortic valve implantation
(TAVI). However, the risk of IE in patients waiting for
TAVI is not well-studied. We present a unique case of a patient waiting for
TAVI with decompensated heart failure who was found... | Infective endocarditis (IE) is associated with significant morbidity and
mortality.1 The presence of foreign material, such as a prosthetic valve,
complicates the management of IE. A large multicenter registry examined outcomes in
patients with IE following transcatheter aortic valve implantation (TAVI), and found
an i... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Infective endocarditis (IE) is associated with significant morbidity and\nmortality.1 The presence of foreign material, such as a prosthetic valve,\ncomplicates the management of IE. A large multicenter registry examined outcomes in\npa... | Infective endocarditis (IE) is associated with significant morbidity and
mortality.1 The presence of foreign material, such as a prosthetic valve,
complicates the management of IE. A large multicenter registry examined outcomes in
patients with IE following transcatheter aortic valve implantation (TAVI), and found
an i... | Bloodwork revealed an elevated white blood cell count of 15.2 × 109/L
(normal 4.0-11.0) and a low hemoglobin at 9.9 g/dL. Of note, the patient
received 2 units of packed red blood cells the day prior. Troponin was elevated
at 1.610 µg/L (normal < 0.012). COVID-19 nasopharyngeal swab was negative.
Chest X-ray showed pat... | The leading diagnosis was decompensated heart failure secondary to progression of
aortic stenosis. The patient was admitted to hospital and diuresis was
initiated. Overnight, he had worsening oxygen requirements and was placed on
bilevel airway pressure (BiPAP). Given the mild leukocytosis, ceftriaxone and
azithromycin... | The patient’s presentation was consistent with a heart failure exacerbation. The
differential for his state of decompensation included valvular (eg, worsening
aortic stenosis), infectious (eg, bacterial pneumonia, COVID-19) and ischemic
triggers.
We report the case of an 85-year-old male with severe aortic stenosis wh... | We present the case of an 85-year-old male awaiting TAVI with decompensated heart
failure due to mitral valve endocarditis. Clinicians should understand that patients
awaiting TAVI have multiple risk factors for IE, including valvular disease,
advanced age, and certain comorbidities. IE should be considered as a cause ... | An 85-year-old male was initially evaluated as an outpatient for aortic stenosis.
His echocardiogram demonstrated a valve area of 0.8 cm2, mean
gradient of 47 mmHg, peak gradient of 91 mmHg and aortic valve peak velocity of
4.76 m/s, in keeping with severe aortic stenosis. Mild mitral regurgitation and
moderate mitral ... | ||||
PMC10015658 | Retroperitoneal lymphangioma as the final diagnosis of a middle-aged woman with abdominal pain: a case report | Journal of Medical Case Reports | 2023-03-15 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015658/ | Background Lymphangiomas are lesions attributed to congenital malformations of the lymphatic system, or acquired chronic obstruction of the lymphatic network due to trauma, radiation, surgical manipulation, inflammation, or infection. Overall, lymaphangiomas are rare, and particularly, retroperitoneal lymphangiomas are... | Lymphangiomas are rare benign lesions originating from lymphatic system . They can be detected at any age, but the infantile type is more common. Any part of the body can be involved, although head and neck, and axilla are more commonly affected. Abdominal lymphangiomas, especially retroperitoneal forms, are found to b... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Lymphangiomas are rare benign lesions originating from lymphatic system . They can be detected at any age, but the infantile type is more common. Any part of the body can be involved, although head and neck, and axilla are more commonly... | Lymphangiomas are rare benign lesions originating from lymphatic system . They can be detected at any age, but the infantile type is more common. Any part of the body can be involved, although head and neck, and axilla are more commonly affected. Abdominal lymphangiomas, especially retroperitoneal forms, are found to b... | A 49-year-old woman presented to the gastroenterology clinic of Taleghani Hospital, a tertiary academic hospital with a persistent epigastric pain radiating to the back for 1 month before admission. The nature of the abdominal pain was exacerbating over time. It did not alter by fasting or eating. She denied any altera... | Lymphangiomas are slow-progressing tumors that are not reported to harbor malignant potential . The known etiologies of lymphangioma are the anomalous connection between lymphatic and venous network, which is commonly seen in children, as well as traumatic degeneration of lymphatic system by radiation, inflammation, in... | Retroperitoneal lymphangiomas are rare lesions with nonspecific symptoms and indistinct imaging clues, which make the diagnosis challenging. When located adjacent to the pancreas or peripancreatic major vessels, differentiation of pancreatic adenocarcinoma or pancreatic cystic lesions, which harbor a malignant potentia... | |||||||
PMC10016210 | Pediatric Undifferentiated Pleomorphic Sarcoma of the Cecum | The Ochsner Journal | 2023-01-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016210/ | © | Background: Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm typically diagnosed in older adults and localized to the extremities or retroperitoneum. Because of poor response to therapy and high rates of recurrence, this neoplasm is associated with a poor prognosis. Case Report: A 12-year-old female ... | Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma (MFH), is a high-grade pleomorphic neoplasm without any definable line of differentiation.1 UPS usually occurs in the extremities or retroperitoneum; primary tumors of the gastrointestinal tract are uncommon. To our knowledge, ... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma (MFH), is a high-grade pleomorphic neoplasm without any definable line of differentiation.1 UPS usually occurs in the extremities or retroperit... | Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma (MFH), is a high-grade pleomorphic neoplasm without any definable line of differentiation.1 UPS usually occurs in the extremities or retroperitoneum; primary tumors of the gastrointestinal tract are uncommon. To our knowledge, ... | A 12-year-old female presented to an urgent care clinic with 1 week of nausea and vomiting. She reported fatigue and chronic intermittent cramping abdominal pain for 4 months and unintentional weight loss of 25 pounds over the last 3 months. On examination, she had pale conjunctiva, tachycardia, and mild abdominal pain... | UPS is a diagnosis of exclusion reserved for sarcomas with a distinct combination of immunohistochemical and microscopic features, made only after careful consideration of other differential diagnoses. This case is unique both for being localized to the gastrointestinal tract, with only 14 cases reported of cecal or as... | Although malignancies of the gastrointestinal tract in pediatric patients are rare, this case exemplifies the need to maintain a broad differential. The case further shows the value of prompt referral and workup by appropriate medical specialists to limit morbidity and mortality. The treatment and long-term outcomes fo... | ||||||
PMC10016364 | Idiopathic Granulomatous Mastitis as an Unusual Cause of Erythema Nodosum in a Malagasy Woman | International Medical Case Reports Journal | 2023-03-11 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016364/ | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at | Introduction Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory disease. Neoplastic and infectious etiologies must be ruled out. IGM is a diagnostic challenge for countries with high tuberculosis endemicity like Madagascar since it may clinically and radiologically mimic breast tuberculosis. We repo... | Idiopathic granulomatous mastitis (IGM) is an uncommon chronic inflammatory disease of the breast characterized by a non-caseating granulomas confined to breast lobules.1 IGM is a rare cause of erythema nodosum. Association of IGM and erythema nodosum is a rare feature, less than 30 cases have been reported in the lite... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Idiopathic granulomatous mastitis (IGM) is an uncommon chronic inflammatory disease of the breast characterized by a non-caseating granulomas confined to breast lobules.1 IGM is a rare cause of erythema nodosum. Association of IGM and e... | Idiopathic granulomatous mastitis (IGM) is an uncommon chronic inflammatory disease of the breast characterized by a non-caseating granulomas confined to breast lobules.1 IGM is a rare cause of erythema nodosum. Association of IGM and erythema nodosum is a rare feature, less than 30 cases have been reported in the lite... | A 29-year-old primiparous Malagasy woman came for a consultation to the dermatological clinic of the Nord Franche-Comté Hospital in June 2020 for painful nodules on her legs typical of erythema nodosum. These lesions developed a month after a swelling of the right breast undergoing etiological investigation. She was no... | IGM was first described by Kessler and Wolloch in 1972 as “a rare benign chronic inflammatory disease of the breast of unknown etiology”.6 It is a subtype of panniculitis characterized by non-caseating granulomatous inflammation located in the lobules.7 IGM is a rare cause of mastopathy. The association of IGM and eryt... | IGM is a benign disease and the awareness of this rare entity prevents delays in diagnosis and unnecessary treatment. Our case highlighted that IGM is a poorly understood disease that often evades to diagnosis. Although the etiology of IGM is unknown, it seems that IGM is an autoimmune disease of the breast. Now, with ... | ||||||
PMC10017236 | Hereditary Hemorrhagic Telangiectasia Presenting with Asymptomatic Liver Lesions and a History of Early-onset Myocardial Infarction and Multiple Intracranial Aneurysms | Internal Medicine | 2022-07-29 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017236/ | The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit ( | Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder of the vasculature, characterized by epistaxis, telangiectasia and arteriovenous malformations in multiple organs. We herein report a 49-year-old woman with a history of early-onset myocardial infarction and intracranial aneurysms, in whom we incidentall... | Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder diagnosed when at least three of the four Curaçao criteria are satisfied: epistaxis; mucocutaneous telangiectasia at characteristic sites such as lips, oral cavity, fingers or nose; visceral lesions such as telangiectases or arteriovenous mal... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder diagnosed when at least three of the four Curaçao criteria are satisfied: epistaxis; mucocutaneous telangiectasia at characteristic sites such as lips, oral c... | Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder diagnosed when at least three of the four Curaçao criteria are satisfied: epistaxis; mucocutaneous telangiectasia at characteristic sites such as lips, oral cavity, fingers or nose; visceral lesions such as telangiectases or arteriovenous mal... | A 49-year-old woman was referred to our hospital following an incidental finding of a low-density area on computed tomography (CT) of the liver suspected to represent peliosis hepatis. She had a history of acute MI treated with percutaneous coronary intervention at 49 years old and had a large left internal carotid ane... | Our patient was referred on suspicion of peliosis hepatis with a history of multiple vascular diseases without identifiable risk factors. She subsequently demonstrated gastrointestinal angioectases and pulmonary arteriovenous fistula. Although she only satisfied two of the diagnostic Curaçao criteria, the multiplicity ... | HHT patients are estimated to develop MI at a frequency of 0.9% (7), which is lower than the value in the general population. However, HHT patients may be at an increased risk of early-onset non-atherosclerotic MI through two HHT-related mechanisms. First, a retrospective study showed an increased incidence of SCAD amo... | ||||||
PMC10017247 | A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease | Internal Medicine | 2022-07-29 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017247/ | The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit ( | A 67-year-old woman with a 5-year history of recurrent swollen eyelids and epistaxis, diagnosed as immunoglobulin G4-related diseases (IgG4-RD) based on hyper-IgG4-emia and IgG4-positive cell infiltration to the lesion, was referred to our department due to recurrent symptoms despite corticosteroid therapies. Computed ... | Immunoglobulin G4-related disease (IgG4-RD) is a fibro-inflammatory disease with simultaneous or metachronous lesions in various organs, first described in 2001 in Japan (1). Elevated serum IgG4 levels and IgG4-positive lymph-plasmacytic infiltration are the landmarks of IgG4-RD; however, those are non-specific immune ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Immunoglobulin G4-related disease (IgG4-RD) is a fibro-inflammatory disease with simultaneous or metachronous lesions in various organs, first described in 2001 in Japan (1). Elevated serum IgG4 levels and IgG4-positive lymph-plasmacyti... | Immunoglobulin G4-related disease (IgG4-RD) is a fibro-inflammatory disease with simultaneous or metachronous lesions in various organs, first described in 2001 in Japan (1). Elevated serum IgG4 levels and IgG4-positive lymph-plasmacytic infiltration are the landmarks of IgG4-RD; however, those are non-specific immune ... | A 62-year-old Asian woman was referred to a local otolaryngologist with a swollen left upper eyelid and repeated epistaxis. Computed tomography (CT) revealed a swollen eyelid and an osteoclastic mass with calcification in the left maxillary sinus. Suspecting malignancy or fungal infection, surgical resection of the sin... | TFIL is a rare idiopathic fibrosclerosing disorder occurring in the head and neck region (6). It radiologically shows a destructive mass mimicking malignancy, but it is histologically benign (6). TFIL is considered an inflammatory pseudotumor, similar to IMT and IgG4-RD (7). There have been 38 cases of TFIL or diseases... | The authors state that they have no Conflict of Interest (COI). | ||||||
PMC10017306 | Acute pancreatitis revealing an isolated hydatid pancreatic cyst simulating a pseudocyst: A case report | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017306/ | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Hydatid disease is a worldwide public health problem, especially in endemic countries, caused by the larval stage of Echinococcus granulosis. The pancreatic location of this disease is exceptional, representing only 1% of all possible locations, making this a widely misdiagnosed entity. We report a case of a 42-year-ol... | Pancreatic hydatid cysts are an exceptional form of hydatid disease, and isolated involvement has rarely been reported . This explains the diagnostic difficulty of this entity. The most common locations of hydatid cysts are liver (50%-77%), lung (15%-47%), spleen (0.5%-8%), and kidney (2%-4%) .
We describe a case of a... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Pancreatic hydatid cysts are an exceptional form of hydatid disease, and isolated involvement has rarely been reported . This explains the diagnostic difficulty of this entity. The most common locations of hydatid cysts are liver (50%-7... | Pancreatic hydatid cysts are an exceptional form of hydatid disease, and isolated involvement has rarely been reported . This explains the diagnostic difficulty of this entity. The most common locations of hydatid cysts are liver (50%-77%), lung (15%-47%), spleen (0.5%-8%), and kidney (2%-4%) .
We describe a case of a... | Hydatidosis is secondary to the development of the larval form of Echinococcus granulosus in humans. Hydatid cysts can touch any organ or structure of the body. However, the pancreatic location has a prevalence of less than 1% . It is isolated in 90% of cases with a predilection for the cephalic part of the pancreas (5... | Hydatid cyst of the pancreas is an extremely rare and widely misdiagnosed entity, especially in case of an isolated cystic lesion simulating a pseudocyst or cystic neoplasm. Hydatid cyst should be considered as one of the differential diagnosis in pancreatic cystic lesions, as well as other organs, especially in patien... | A 42-year-old male, with a history of alcoholism and recurring abdominal pain, originating from an endemic area of hydatid disease in North Africa, was admitted to the emergency department, for an acute onset of severe central epigastric pain radiating through the back and exacerbated in supine position, associated to ... | ||||||
PMC10017403 | A case of reversible hypoparathyroidism in a patient with Riedel's thyroiditis treated with glucocorticoids | Clinical Case Reports | 2023-03-15 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017403/ | This is an open access article under the terms of the | Abstract A 48‐year‐old woman with a history of primary hypothyroidism, presented with compressive symptoms secondary to a rapid enlargement of a preexisting goiter. She had no clinical signs of hypocalcemia. Biological tests revealed hypoparathyroidism. Cervicothoracic computed tomography scan showed a heterogeneous co... | 1
Riedel's thyroiditis (RT) is a rare benign fibroinflammatory thyroid disease. Its estimated incidence is suggested to be one case per 100,000 inhabitants.
1
The pathophysiological mechanisms of RT are still unclear. Three possible theories were suggested. The most defended one is the thyroid involvement by the mult... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "1\n\nRiedel's thyroiditis (RT) is a rare benign fibroinflammatory thyroid disease. Its estimated incidence is suggested to be one case per 100,000 inhabitants.\n1\n The pathophysiological mechanisms of RT are still unclear. Three possib... | 1
Riedel's thyroiditis (RT) is a rare benign fibroinflammatory thyroid disease. Its estimated incidence is suggested to be one case per 100,000 inhabitants.
1
The pathophysiological mechanisms of RT are still unclear. Three possible theories were suggested. The most defended one is the thyroid involvement by the mult... | 2
A 48‐year‐old woman was referred to our department for a compressive goiter. Her past medical history included primary hypothyroidism diagnosed at the age of 46 years and treated with 100 μg per day of levothyroxine. Her initial cervical ultrasound showed a heterogeneous goiter with a right lobar nodule of 22 mm and... | 3
Riedel's thyroiditis is a rare disease that affects women aged between 30 and 50 years.
7
Its clinical presentation and diagnosis are often complex. The most common symptoms in patients with RT are thyroid enlargement (89%), dyspnea (50%), hoarse voice (41%), and neck pain (41%).
1
Other signs such as exophthalmos... | 4
RT is a rare thyroid disease with extending fibrosis to surrounding tissues. The involvement of the parathyroid glands may be clinically silent. Early surgical decompression of the goiter and the administration of glucocorticoids may be effective in reducing the fibrosclerotic process and lead to the recovery of par... | Salma Salhi: Data curation; formal analysis; resources; writing – original draft; writing – review and editing. Ibtissem Oueslati: Conceptualization; data curation; formal analysis; investigation; methodology; project administration; supervision; validation; visualization; writing – original draft; writing – review and... | |||||
PMC10017406 | Extensive right‐sided endocarditis in double‐chamber right ventricle presented with leukocytoclastic vasculitis | Clinical Case Reports | 2023-03-15 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017406/ | This is an open access article under the terms of the | Abstract Congenital heart disease is a risk factor for infective endocarditis (IE). Ventricular septal defects and ventricular outflow tract obstructions are this population's most common causes of endocarditis. We present a patient diagnosed with leukocytoclastic vasculitis, renal, and pulmonary involvement with right... | 1
We report a patient with a double‐chambered right ventricle (DCRV) and extensive right‐sided infective endocarditis (IE) with an initial presentation of leukocytoclastic vasculitis.
DCRV is a form of right ventricular outflow tract (RVOT) obstruction caused by anomalous muscular or fibromuscular bundles dividing th... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "1\n\nWe report a patient with a double‐chambered right ventricle (DCRV) and extensive right‐sided infective endocarditis (IE) with an initial presentation of leukocytoclastic vasculitis.\n\nDCRV is a form of right ventricular outflow tr... | 1
We report a patient with a double‐chambered right ventricle (DCRV) and extensive right‐sided infective endocarditis (IE) with an initial presentation of leukocytoclastic vasculitis.
DCRV is a form of right ventricular outflow tract (RVOT) obstruction caused by anomalous muscular or fibromuscular bundles dividing th... | 2
A 37‐year‐old female patient suffering with petechia and purpura for 7 months was diagnosed with leukocytoclastic vasculitis confirmed by biopsy. Despite receiving anti‐inflammatory treatments, she was admitted to the hospital due to the gradual progression of constitutional symptoms, pancytopenia, and new pulmonary... | 3
According to previous studies, unrepaired VSD is the most common congenital abnormality associated with the highest risk of IE,
1
followed by ventricular outflow tract obstruction.
2
Both conditions were present in this patient. Berglund et al. demonstrated that a small and unrepaired VSD could increase the incide... | Akram Nakhaee: Project administration; writing – original draft; writing – review and editing. Parisa Koohsari: Resources; writing – original draft. Mehrzad Rahmanian: Resources. Akram Sardari: Resources. Roya Parkhideh: Resources.
The authors declare no conflict of interest.
No funding was received for this study.
... | ||||||
PMC10017931 | Treatment of Orofacial Granulomatosis—9-Month Follow-up: A Case Report | Clinical Medicine Insights. Case Reports | 2023-03-14 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017931/ | This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( | Orofacial granulomatosis is a condition that manifests clinically as painless labial enlargement, perioral and mucosal edema, oral ulcers, and gingivitis. It is characterized by non-necrotizing granulomatous inflammation of the oral and maxillofacial region. When the swelling only affects the lips, the pathology is cal... | The term orofacial granulomatosis (OFG) describes a group of conditions characterized by typical features of noncaseating granuloma, lymphocytic infiltration, and edema at various sites in the oral cavity.1 There are 2 clinical variants of the syndrome: Melkersson-Rosenthal syndrome, which is characterized by unilatera... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "The term orofacial granulomatosis (OFG) describes a group of conditions characterized by typical features of noncaseating granuloma, lymphocytic infiltration, and edema at various sites in the oral cavity.1 There are 2 clinical variants... | The term orofacial granulomatosis (OFG) describes a group of conditions characterized by typical features of noncaseating granuloma, lymphocytic infiltration, and edema at various sites in the oral cavity.1 There are 2 clinical variants of the syndrome: Melkersson-Rosenthal syndrome, which is characterized by unilatera... | A 15-year-old male patient presented at the Oral Medicine Department of the University Clinical Center with swelling of the upper lip that had persisted for 3 years. The patient claimed that the edema of the lip recurred numerous times each year without causing any pain. There was no history of allergies or systemic di... | Although several hypotheses, such as infection, genetic predisposition, and allergy, have been proposed, the precise cause of orofacial granulomatosis is still unknown.7 As in our case, no correlation was found between OFG and systemic conditions such Crohn’s disease or sarcoidosis in a study by Marcoval et al8 There i... | Orofacial granulomatosis can be recurrent and may involve inflammation not only at the labial level, but also the gingival, lingual, buccal, or suborbital levels. Differential diagnosis is required to exclude infections, Crohn’s disease, sarcoidosis, and allergic reactions. Biopsy remains the most definitive way to dia... | A biopsy was performed from a gingival sample. The sample was stained with CK-MNF immunohistochemical stain, which marks epithelial components. Under the squamous epithelium without atypia, dense lymphoplasmacytic inflammatory infiltrate and some multinucleated giant cells could be seen. There was also a proliferation ... | |||||
PMC10018382 | Pulmonary embolism or COVID‐19 pneumonia? A case report | Respirology Case Reports | 2023-03-16 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018382/ | This is an open access article under the terms of the | Abstract Pulmonary embolism (PE) is the most severe clinical presentation of venous thromboembolism (VTE), which can be challenging to diagnose due to its non‐specific symptoms. The overlapping clinical symptoms of Coronavirus disease 2019 (COVID‐19) and PE may make distinguishing between the two difficult. Thus, the d... | Pulmonary embolism (PE), the most lethal presentation of venous thromboembolism (VTE), often arises from deep venous thrombosis (DVT). However, PE can originate de‐novo without any evidence of DVT.
1
Major risk factors for PE include immobilization, smoking, obesity, malignancy, recent surgery, acute and chronic medic... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Pulmonary embolism (PE), the most lethal presentation of venous thromboembolism (VTE), often arises from deep venous thrombosis (DVT). However, PE can originate de‐novo without any evidence of DVT.\n1\n Major risk factors for PE include... | Pulmonary embolism (PE), the most lethal presentation of venous thromboembolism (VTE), often arises from deep venous thrombosis (DVT). However, PE can originate de‐novo without any evidence of DVT.
1
Major risk factors for PE include immobilization, smoking, obesity, malignancy, recent surgery, acute and chronic medic... | In January 2022, at the height of the COVID‐19 Omicron pandemic, a 63‐year‐old Iranian woman was referred to our hospital with confusion, disorientation, severe agitation, visual and auditory hallucinations, and impaired sleep. She had a 2‐year history of dementia with progressive behavioural and psychological disturba... | As the coronavirus pandemic is exerting pressure on health systems all over the world, physicians must stay tuned and have a high index of suspicion for COVID‐19; however, focusing too much on this disease can hinder timely diagnosis and prompt treatment of non‐COVID severe conditions.
5
In the patient described above... | During the COVID‐19 pandemic, a high index of suspicion is required for the timely diagnosis of PE, especially in patients with identifiable risk factors. This is especially true for older adults with neurocognitive disorders, in whom delirium may complicate the presentation of PE. Thus, awareness of the differences in... | Nahid Borna has made substantial contributions to the acquisition of data and was a major contributor to writing the manuscript. Maryam Niksolat, Behnam Shariati, and Vahid Saeedi have made contributions to the acquisition of data. Leila Kamalzadeh has made substantial contributions to the conception of the work and wa... | |||||
PMC10018411 | Anticoagulation therapy for pulmonary embolism involving a myxoma mimicking, giant type C thrombus: A case report | Journal of Biomedical Research | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018411/ | This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit | Right heart thrombus (RHTh) with concurrent acute pulmonary embolism (PE) is rare and can seriously destabilize hemodynamics, leading to an emergency situation with high mortality. Diagnosis and treatment of RHTh with acute PE are not yet standardized. There are few reports of acute PE concurrent with RHTh and even les... | Venous thromboembolism (VTE), which can present clinically as pulmonary embolism (PE) and/or deep vein thrombosis (DVT), is the third most frequent acute cardiovascular syndrome worldwide, after myocardial infarction and cerebrovascular incidents such as stroke. The global annual incidence of PE ranges from 40 to 120 c... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Venous thromboembolism (VTE), which can present clinically as pulmonary embolism (PE) and/or deep vein thrombosis (DVT), is the third most frequent acute cardiovascular syndrome worldwide, after myocardial infarction and cerebrovascular... | Venous thromboembolism (VTE), which can present clinically as pulmonary embolism (PE) and/or deep vein thrombosis (DVT), is the third most frequent acute cardiovascular syndrome worldwide, after myocardial infarction and cerebrovascular incidents such as stroke. The global annual incidence of PE ranges from 40 to 120 c... | A 76-year-old man with a history of essential arterial hypertension was admitted to hospital after experiencing blood in his sputum followed by eight days of progressive dyspnea. This patient was on a regular course of Lercanidipine (10 mg) and Valsartan (160 mg) to be ingested once daily. Upon presentation this man ha... | In isolation, PE is associated with relatively high mortality. Studies have found that the all-cause mortality rate is 1.9% to 2.9% on day 7 and 4.9% to 6.6% on day 30. Even though PE with RHTh is rare, we do know managing this comorbid disorder is complicated and early mortality is significantly increased. The mortali... | None. | ||||||
PMC10019824 | Primary cardiac mesothelioma presenting with fulminant recurrent pericarditis: a case report | European Heart Journal: Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019824/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( | Abstract Background Primary pericardial mesothelioma is an extremely rare disease. Prognosis is poor, with little effects of chemo- or radio-therapy. The majority of cases is diagnosed at autopsy. Case summary A 22-year-old man, who presented with recurrent pericarditis and large pericardial effusion 2 months after a s... | Primary pericardial mesothelioma is an extremely rare disease that accounts for 0.8% of all mesotheliomas and 2–3% of all pericardial tumours.1,2 Prognosis is very poor, with little effects of chemo- or radio-therapy and median survival about 4–6 months.3 The majority of cases is diagnosed at autopsy,4 with anecdotal c... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Primary pericardial mesothelioma is an extremely rare disease that accounts for 0.8% of all mesotheliomas and 2–3% of all pericardial tumours.1,2 Prognosis is very poor, with little effects of chemo- or radio-therapy and median survival... | Primary pericardial mesothelioma is an extremely rare disease that accounts for 0.8% of all mesotheliomas and 2–3% of all pericardial tumours.1,2 Prognosis is very poor, with little effects of chemo- or radio-therapy and median survival about 4–6 months.3 The majority of cases is diagnosed at autopsy,4 with anecdotal c... | A 22-year-old healthy male presented with a 4-day pleuritic chest pain and dyspnoea. There was no history of smoking or previous asbestos exposure. He had received his second BNT162b2 (Pfizer-BioNTech) vaccine a month earlier. Heart rate was 121 b.p.m. and blood pressure 144/95 mmHg. He was afebrile without abnormal au... | Our initial working hypothesis was that the patient had fulminant recurrent pericarditis complicated by pericardial tamponade. After an episode of acute pericarditis, the probability of developing incessant pericarditis or first recurrence within 18 months is 15–30%, with 25–50% likelihood of additional recurrence afte... | Primary pericardial mesothelioma should be considered in the differential diagnosis of refractory recurrent pericarditis, even with prior biopsy-proven pericarditis. Extensive pericardial involvement by the pericardial malignancy can mimic pericardial effusion on cardiac imaging, which can be particularly misleading if... | DateEvent1 February 2021• Patient receives second BNT162b2 COVID-19 vaccine10 March 2021• First episode of pericarditis with moderate pericardial effusion• Pericardiocentesis removal of 900 cc of sero-sanguineous exudative fluid• Discharged with ibuprofen and colchicine treatment1 April 2021• Readmitted with large peri... | |||||
PMC10019861 | A Young Woman with Autosomal Dominant Hyper Immunoglobulin E (job’s) Syndrome Presenting with Acute Abdomen: a Case Report | Medical Archives | 2022-12-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019861/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( | Background: Autosomal dominant hyper immunoglobulin IgE syndrome is a rare inherited condition that causes immune suppression. Objective: This case report describes a severe case of liver abscess, caused by a cavity-forming infection, secondary to Job’s syndrome. Case presentation: A 25-year-old female patient was emer... | 1.
Although one might think that genetic disease is a far cry from the ailments of everyday surgical practice, the modern surgeon must be prepared to effectively treat any and all causes of surgical pathology. This case report describes a severe case of liver abscess, caused by a cavity-forming infection, secondary to... | [
{
"section_type": "background",
"heading": "BACKGROUND",
"text": "1.\n\nAlthough one might think that genetic disease is a far cry from the ailments of everyday surgical practice, the modern surgeon must be prepared to effectively treat any and all causes of surgical pathology. This case report describe... | 1.
Although one might think that genetic disease is a far cry from the ailments of everyday surgical practice, the modern surgeon must be prepared to effectively treat any and all causes of surgical pathology. This case report describes a severe case of liver abscess, caused by a cavity-forming infection, secondary to... | 3.
Patient Information: A 25-year-old female patient, presented at the emergency department complaining of severe abdominal pain. The patient’s detailed medical history revealed a series of recurrent pulmonary infections for which she was treated, as well as a known diagnosis of Job’s syndrome since childhood. The pat... | 4.
Autosomal dominant hyper immunoglobulin IgE syndrome is a rare inherited condition that causes immune suppression. The pathogenesis of the syndrome is most commonly attributed to missense variants of various domains in the STAT3 gene. The STAT3 protein is a major component within the JAK-STAT signaling pathway (1, ... | 5.
In patients with a known history of the autosomal dominant hyper-IgE syndrome, presenting with acute abdominal pain, the liver abscess must be on the top of the differential diagnosis list. Despite being a genetic disease, Job’s syndrome has the potential to require immediate surgical management by the general surg... | 2.
The aim of this case report was to describe a severe case of liver abscess, caused by a cavity-forming infection, secondary to Job’s syndrome. | |||||
PMC10020975 | Evaluations of coronary microvascular dysfunction in a patient with thrombotic microangiopathy and cardiac troponin elevation: a case report | European Heart Journal: Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020975/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( | Abstract Background Thrombotic microangiopathy (TMA) syndromes include thrombotic thrombocytopenic purpura (TTP) and haemolytic uremic syndrome, and contribute to myocardial infarction and multiple organ failure. Although coronary microvascular dysfunction (CMD) is the key for understanding the pathophysiology of cardi... | Thrombotic microangiopathy (TMA) is a spectrum of life-threatening syndromes, including thrombotic thrombocytopenic purpura (TTP) and haemolytic uremic syndrome (HUS).1 The mechanisms underlying TMA involve platelet aggregation and increased mechanical stress in the microcirculation that contribute to multiple organ fa... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Thrombotic microangiopathy (TMA) is a spectrum of life-threatening syndromes, including thrombotic thrombocytopenic purpura (TTP) and haemolytic uremic syndrome (HUS).1 The mechanisms underlying TMA involve platelet aggregation and incr... | Thrombotic microangiopathy (TMA) is a spectrum of life-threatening syndromes, including thrombotic thrombocytopenic purpura (TTP) and haemolytic uremic syndrome (HUS).1 The mechanisms underlying TMA involve platelet aggregation and increased mechanical stress in the microcirculation that contribute to multiple organ fa... | An 80-year-old woman presented to the emergency department with a 2-week history of worsening back pain, a 5-day history of dyspnoea on exertion, and high temperature. Approximately 2 weeks before admission she had an episode of back pain and high temperature, and 2 days before admission, she had transient unconsciousn... | Coronary microvascular dysfunction is the mechanism underlying myocardial infarction/injury with or without epicardial obstructive coronary artery stenosis.4 TMA is a spectrum of life-threatening syndromes, in which haemolytic anaemia and thrombocytopaenia are associated with multiple organ damage.1,2 Complications inc... | In vivo evaluations of coronary microvascular function can provide mechanistic insights into the cardiac involvement in TMA. Further studies are warranted to determine whether non-invasive assessment of microvascular function enables disease progression predictions and provides prognostic implications beyond cardiac tr... | AdmissionDay 1Treatment with bi-level positive airway pressure (BiPAP), carperitide, diuretics, and antibiotics in the intensive care unit.Blood culture and urine cultures were performed.Day 2Transient neurologic deficits. Fresh frozen plasma (FFP) infusion.Day 3Treatment with steroid pulse therapy (1 g/day for 3 days)... | |||||
PMC10021098 | Sympathetic ophthalmia in an 85-year-old female and a 90-year-old
male after a non-complicated cataract surgery: a case report | The Journal of International Medical Research | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021098/ | Creative Commons Non Commercial CC BY-NC: This article is distributed
under the terms of the Creative Commons Attribution-NonCommercial 4.0
License ( | Here, two cases involving the oldest reported patients with sympathetic
ophthalmia (SO) after non-complicated cataract surgery, are reported. The first
case was an 85-year-old female with bilateral decreased vision and headache. The
best-corrected visual acuity (BCVA) was 0.8 in the right eye and 1.0 in the left
eye at... | Sympathetic ophthalmia (SO) is defined as bilateral granulomatous uveitis that occurs
after a penetrating ocular trauma or intraocular surgery in one eye. SO resembles
Vogt–Koyanagi–Harada (VKH) disease, with autoimmune responses to melanocytes
commonly playing a role in the occurrence of both diseases. SO is a rare di... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Sympathetic ophthalmia (SO) is defined as bilateral granulomatous uveitis that occurs\nafter a penetrating ocular trauma or intraocular surgery in one eye. SO resembles\nVogt–Koyanagi–Harada (VKH) disease, with autoimmune responses to m... | Sympathetic ophthalmia (SO) is defined as bilateral granulomatous uveitis that occurs
after a penetrating ocular trauma or intraocular surgery in one eye. SO resembles
Vogt–Koyanagi–Harada (VKH) disease, with autoimmune responses to melanocytes
commonly playing a role in the occurrence of both diseases. SO is a rare di... | To the best of our knowledge, the present study describes the oldest reported
patients with SO from anywhere in the world. The present cases were not typical,
particularly case 1; therefore, differential diagnoses were important. The
differential diagnoses included VKH disease, SO, and uveal effusion syndrome. The
abse... | An 85-year-old female patient presented at Dokkyo Medical University Saitama
Medical Centre, Koshigaya, Japan in April 2020, with decreased vision in both
eyes after a non-complicated bilateral cataract surgery 13 years previously. She
also had headache, and she had been diagnosed with VKH disease at a previous eye
cli... | |||||||
PMC10023226 | Rare Presentation of Small Bowel Obstruction Secondary to Intestinal Leiomyoma in a Patient with Crohn's Disease | Case Reports in Surgery | 2023-01-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023226/ | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | Small bowel obstructions (SBOs) are surgical emergencies that can occur with mechanical blockage of the intestinal lumen. These blockages are most commonly caused by adhesions or hernias, but can also result from intestinal neoplasms. This case report documents the rare occurrence of SBO due to a submucosal leiomyoma. ... | Small bowel obstructions (SBOs) are surgical emergencies that can occur with mechanical blockage of the intestinal lumen. These blockages are most commonly caused by adhesions or hernias . Other common etiologies include inflammatory strictures, foreign bodies, and neoplasms [1, 2]. Despite comprising a vast majority o... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Small bowel obstructions (SBOs) are surgical emergencies that can occur with mechanical blockage of the intestinal lumen. These blockages are most commonly caused by adhesions or hernias . Other common etiologies include inflammatory... | Small bowel obstructions (SBOs) are surgical emergencies that can occur with mechanical blockage of the intestinal lumen. These blockages are most commonly caused by adhesions or hernias . Other common etiologies include inflammatory strictures, foreign bodies, and neoplasms [1, 2]. Despite comprising a vast majority o... | A 54-year-old male presented to our outpatient general surgery office on a referral from his gastroenterologist. The patient reported a 2-month history of worsening abdominal pain, bloating, and emesis, with an accompanying 50-pound weight loss. His presentation raised concern for bowel obstruction.
The patient's medi... | Here, we highlight the diagnostic challenges that submucosal leiomyomas can pose, especially in patients with concurrent inflammatory bowel disease. Our patient's symptoms had an insidious onset that occurred over several months, and several imaging modalities (X-ray, CT, and capsule endoscopy) failed to identify the m... | This case report describes the clinical presentation of SBO secondary to a submucosal leiomyoma that formed in a patient with a history of Crohn's disease. Leiomyomas should always be considered as a potential, albeit rare, cause of SBO. Diagnosis can be difficult for clinicians, as evidenced by the lack of detection f... | ||||||
PMC10023239 | Intussusception of the appendix in a young adult: an important differential diagnosis of abdominal pain in cystic fibrosis patients? | Journal of Surgical Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023239/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( | Abstract Cystic fibrosis (CF) is commonly associated with gastrointestinal manifestations from infancy to adulthood. Distal intestinal obstruction syndrome (DIOS) affects 20% of CF patients, where intussusception can be a rare complication. A 20-year-old CF male was diagnosed with a 3-day history of right iliac fossa p... | Cystic fibrosis (CF) is commonly associated with gastrointestinal manifestations from birth to adulthood. Patients with CF have an increased risk of intestinal disorders due to pancreatic insufficiency, resulting in malabsorption, mucous thickening and slowing gastrointestinal transit . Such disorders include intussusc... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Cystic fibrosis (CF) is commonly associated with gastrointestinal manifestations from birth to adulthood. Patients with CF have an increased risk of intestinal disorders due to pancreatic insufficiency, resulting in malabsorption, mucou... | Cystic fibrosis (CF) is commonly associated with gastrointestinal manifestations from birth to adulthood. Patients with CF have an increased risk of intestinal disorders due to pancreatic insufficiency, resulting in malabsorption, mucous thickening and slowing gastrointestinal transit . Such disorders include intussusc... | Literature review shows a scarcity of research with only 10 cases of intussusception in adult CF patients reported . To our knowledge, only two cases of appendiceal intussusception in CF adults have been reported, in patients aged 18 and 19 years old, respectively, suggesting a predilection for young adults [5, 6].
In... | From this rare case presentation of appendiceal intussusception in a CF adult, we have learnt it is imperative to carry a higher index of suspicion of gastrointestinal complications in CF patients. Acute appendicitis is seen less often in this patient cohort and differentials such as DIOS and intussusception should be ... | We report a case of a 20-year-old male with CF, who was admitted to the emergency department with a 3-day history of intermittent right iliac fossa pain and diarrhoea. He presented with no nausea or vomiting and had no history of previous abdominal surgery. The patient was taking regular CF-related medications includin... | ||||||
PMC10023517 | Unusual presentation of rheumatoid arthritis in a 106‐year‐old woman: A rare case report | Clinical Case Reports | 2023-03-17 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023517/ | This is an open access article under the terms of the | Abstract By reporting this case, we hope to encourage medical professionals to concentrate on diagnosing old patients with unusual presentation of rheumatoid arthritis. | 1
Rheumatoid arthritis is a systemic autoimmune disease with a peak incidence between the ages of 30 and 50 years old. Rheumatoid arthritis that first appears in people over the age of 60 is commonly referred to as “elderly onset Rheumatoid Arthritis.” We present an extremely rare case of a 106‐year‐old female newly d... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "1\n\nRheumatoid arthritis is a systemic autoimmune disease with a peak incidence between the ages of 30 and 50 years old. Rheumatoid arthritis that first appears in people over the age of 60 is commonly referred to as “elderly onset Rhe... | 1
Rheumatoid arthritis is a systemic autoimmune disease with a peak incidence between the ages of 30 and 50 years old. Rheumatoid arthritis that first appears in people over the age of 60 is commonly referred to as “elderly onset Rheumatoid Arthritis.” We present an extremely rare case of a 106‐year‐old female newly d... | 2
A 106‐year‐old female presented with generalized bone pain, low‐grade fever, and the inability to walk; she was previously able to walk alone in her home without an assistant. She went to a a general practitioner, who misdiagnosed her with osteomalacia and gave her vitamin D and calcium supplements. Her family histo... | 3
RA is a chronic, multisystemic inflammatory disease marked by damaging synovitis. It may affect any joint; however, it is most often associated with erosive alterations in the tiny joints of the hand and foot. RA is a progressive condition that causes diminished functional ability and quality of life, as well as hig... | 4
Our case highlights a rare occurrence of newly diagnosed rheumatoid arthritis in an extremely old female (106 years old) that is rarely reported in the medical literature. By reporting this case, we hope to encourage medical professionals to concentrate on diagnosing old patients with unusual presentation of rheumat... | Ali ALQazzaz: Conceptualization; investigation; project administration; supervision. Faiq I. Gorial: Data curation; formal analysis; resources. Ahmed Dheyaa Al‐Obaidi: Data curation; supervision; writing – original draft; writing – review and editing. Mustafa Najah Al‐Obaidi: Data curation; writing – original draft; wr... | |||||
PMC10023518 | Postpartum fevers, a rare presentation of secondary hemophagocytic lymphohistiocytosis | Clinical Case Reports | 2023-03-17 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023518/ | This is an open access article under the terms of the | Abstract Hemophagocytic lymphohistiocytosis (HLH) is a rare disease of excessive immune system activation. We report a case of HLH in a 20‐year‐old primigravid woman who presented with postpartum fevers. She was successfully treated with dexamethasone and anakinra, a deviation from the HLH‐94 protocol, to preserve her ... | 1
Hemophagocytic lymphohistiocytosis (HLH) is a rare disease of immune dysregulation that mimics many other conditions at presentation. Prompt diagnosis and treatment of pregnancy‐related HLH is critical to reduce maternal‐fetal morbidity and mortality. Current diagnostic criteria for HLH, as determined by the 2004 Hi... | [
{
"section_type": "background",
"heading": "BACKGROUND",
"text": "1\n\nHemophagocytic lymphohistiocytosis (HLH) is a rare disease of immune dysregulation that mimics many other conditions at presentation. Prompt diagnosis and treatment of pregnancy‐related HLH is critical to reduce maternal‐fetal morbid... | 1
Hemophagocytic lymphohistiocytosis (HLH) is a rare disease of immune dysregulation that mimics many other conditions at presentation. Prompt diagnosis and treatment of pregnancy‐related HLH is critical to reduce maternal‐fetal morbidity and mortality. Current diagnostic criteria for HLH, as determined by the 2004 Hi... | 2
We report the case of a 20‐year‐old primigravid woman, previously healthy, who had a spontaneous vaginal delivery of a healthy female infant at term. Her delivery was complicated by postpartum hemorrhage, attributed to retained placenta (requiring manual extraction), as well as fevers of unknown origin. She underwen... | 3
Pathology from our patient's initial D&C was notable for severe acute‐on‐chronic inflammation and necrosis concerning for infection. A computed tomography scan of her abdomen and pelvis showed a heterogeneous and mildly enlarged uterus, no intra‐abdominal abscess/fluid collection, and hepatomegaly with steatosis. Sh... | 5
To preserve our patient's ability to breastfeed and to avoid etoposide‐related toxicity in a young person, we substituted the etoposide in the HLH‐94 regimen with anakinra. Limited retrospective data in pediatric and adult HLH cases showed anakinra and dexamethasone had good overall survival and low hospital‐related... | 4
Our broad differential diagnoses for postpartum fevers includes infectious, autoimmune, rheumatologic, and malignant etiologies. As previously discussed, our patient met all eight diagnostic HLH criteria. Given her young age and the rarity of postpartum HLH, we worked her up for primary HLH and other causes of secon... | 6
Our patient was successfully discharged home on anakinra and dexamethasone with close outpatient hematology follow‐up. She continued to show clinical improvement as demonstrated by downtrending liver enzymes and ferritin levels, along with uptrending hemoglobin levels. She was successfully tapered off dexamethasone/... | ||||
PMC10023671 | Pancreatic pseudocyst as a cause for gastric outlet obstruction | Clinical Case Reports | 2023-03-17 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023671/ | This is an open access article under the terms of the | Abstract The pancreatic pseudocyst contains pancreatic enzymes encapsulated by a non‐epithelialized wall. They are rare in the pediatric population and are mostly a result of pancreatic trauma: extrinsic, or intrinsic. Management options include conservative or surgical, depending on the clinical signs and symptoms, an... | 1
Pancreatic pseudocysts (PP) are fluid‐filled sacs that contain pancreatic enzymes and are encapsulated by a non‐epithelialized wall of fibrous tissue.
1
PP are the most common lesions of the pancreas with an overall prevalence of 0.5–1 in 100,000 adults per year, but rather rare in the pediatric population.
1
,
2
... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "1\n\nPancreatic pseudocysts (PP) are fluid‐filled sacs that contain pancreatic enzymes and are encapsulated by a non‐epithelialized wall of fibrous tissue.\n1\n PP are the most common lesions of the pancreas with an overall prevalence o... | 1
Pancreatic pseudocysts (PP) are fluid‐filled sacs that contain pancreatic enzymes and are encapsulated by a non‐epithelialized wall of fibrous tissue.
1
PP are the most common lesions of the pancreas with an overall prevalence of 0.5–1 in 100,000 adults per year, but rather rare in the pediatric population.
1
,
2
... | 3
An 8‐year‐old female presented with a 3‐day history of postprandial projectile vomiting of recently eaten food material associated with nonradiating upper abdominal pain, colicky with no relieving factors. It was associated with slight abdominal distension following feeds, generalized body malaise, and constipation.... | 4
PP are capsulated non‐epithelialized fluid‐filled sacs as a result of disruption to one or many pancreatic ducts and consequent leakage of pancreatic enzymes into the surrounding soft tissues.
3
The commonest causes are trauma, pancreatitis, gallstones, and drug‐induced but trauma is the commonest cause of PP in th... | 5
PP are rare in children with trauma being the major causative factor. Smaller and asymptomatic PP can be managed conservatively with little to no recurrences. Larger and/or symptomatic PP need to be drained surgically depending on the availability of resources and trained personnel. The management however should be ... | 2
PP are rare in children with trauma and pancreatitis being the commonest causes. Management ranges from conservative to different types of drainage techniques depending on the clinical characteristics of the cyst and patient; therefore, treatment should be individualized from patient to patient.
Mujaheed Suleman: I... | |||||
PMC10023853 | Wilms tumor: A case report with typical clinical and radiologic features in a 3-year-old male | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023853/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Wilms’ tumor, also known as nephroblastoma, is a rare cancer of the kidney that occurs almost exclusively in children. In this case report, a 3-year-old male presented to the hospital with left flank swelling and recurrent fever of 4 months duration. On examination, the abdomen was distended, with associated left flank... | Wilms’ tumor (WT), also known as nephroblastoma, is a rare cancer of the kidney that occurs almost exclusively in children . It accounts for about 95% of all renal tumors in childhood and it is the most common renal malignancy in children under 15 years. It affects approximately 1 in 10,000 children worldwide and is mo... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Wilms’ tumor (WT), also known as nephroblastoma, is a rare cancer of the kidney that occurs almost exclusively in children . It accounts for about 95% of all renal tumors in childhood and it is the most common renal malignancy in childr... | Wilms’ tumor (WT), also known as nephroblastoma, is a rare cancer of the kidney that occurs almost exclusively in children . It accounts for about 95% of all renal tumors in childhood and it is the most common renal malignancy in children under 15 years. It affects approximately 1 in 10,000 children worldwide and is mo... | A 3-year-old Nigerian male presented with left flank swelling and recurrent fever of 4 months. The left flank swelling had progressively increased in size, but there was no associated pain, no swelling in other parts of the body, no hematuria, no reduction in urine output, no leg or facial swelling, no cough or difficu... | Wilms tumor typically arises from mesodermal precursors of the renal parenchyma . About 75% of children are diagnosed between 2 and 5 years of age, and the median age is 3.5 years. This patient is 3 years old. Pathologically, these tumors are usually well circumscribed or macrolobulated, with areas of hemorrhage and ce... | Wilms tumor is the most common pediatric solid renal tumor. Imaging is important in the diagnosis and management of this disease condition. The role of imaging in the diagnosis of WT has been described in this case. | Informed consent was obtained prior to performing the procedure, including permission for publication of all photographs and images included herein. | |||||
PMC10023862 | A case of Gorlin syndrome like phenotype with multiple infundibulocystic basal cell carcinomas in a moniliform blepharosis arrangement | JAAD Case Reports | 2023-04-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023862/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Basal cell nevus syndrome (BCNS), also known as Gorlin syndrome is an autosomal dominant disorder most commonly associated with mutations in the patched tumor suppressor genes (PTCH) 1, or rarely PTCH2 or suppressor of fused homolog (SUFU).1 In addition to numerous cutaneous basal cell carcinomas (BCCs) and palmoplanta... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Basal cell nevus syndrome (BCNS), also known as Gorlin syndrome is an autosomal dominant disorder most commonly associated with mutations in the patched tumor suppressor genes (PTCH) 1, or rarely PTCH2 or suppressor of fused homolog (SU... | Basal cell nevus syndrome (BCNS), also known as Gorlin syndrome is an autosomal dominant disorder most commonly associated with mutations in the patched tumor suppressor genes (PTCH) 1, or rarely PTCH2 or suppressor of fused homolog (SUFU).1 In addition to numerous cutaneous basal cell carcinomas (BCCs) and palmoplanta... | A 57-year-old Fitzpatrick III female with a past medical history of numerous BCCs since 2015, cervical polyps, uterine fibroids, Plummer Vinson syndrome, arthritis, and decreased visual acuity presents with numerous growths on her eyelids for several years. She denied a family history of BCCs, but reported that her mot... | Other genodermatoses that are characterized by multiple BCCs as a primary feature include MHIBCC, Rombo syndrome, Bazex-Dupre-Christol syndrome, and xeroderma pigmentosa; each one with their unique presentations. Bazex-Dupre-Christol syndrome tends to also effect hair follicles and results in less growth, coarse textur... | None disclosed. | |||||||
PMC10023931 | Multiple fibrofolliculomas within a fibrous cephalic plaque in a patient with tuberous sclerosis | JAAD Case Reports | 2023-04-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023931/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Fibrofolliculoma is a hamartomatous cutaneous lesion that usually occurs on the face and neck. Multiple fibrofolliculomas are characteristically found in Birt-Hogg-Dubé (BHD) Syndrome.1 Less commonly, they can also present as isolated, solitary lesions. The presence of a fibrous cephalic plaque (FCP) or multiple angiof... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Fibrofolliculoma is a hamartomatous cutaneous lesion that usually occurs on the face and neck. Multiple fibrofolliculomas are characteristically found in Birt-Hogg-Dubé (BHD) Syndrome.1 Less commonly, they can also present as isolated, ... | Fibrofolliculoma is a hamartomatous cutaneous lesion that usually occurs on the face and neck. Multiple fibrofolliculomas are characteristically found in Birt-Hogg-Dubé (BHD) Syndrome.1 Less commonly, they can also present as isolated, solitary lesions. The presence of a fibrous cephalic plaque (FCP) or multiple angiof... | A 52-year-old African American man with a long-standing diagnosis of TSC presented to our clinic for evaluation of his facial lesions (referred by his neurologist who encouraged him to follow-up with specialists for establishment of care for his TSC). A physical exam revealed multiple firm brown dome-shaped papules on ... | TSC is characterized by mutations in either the TSC1 or TSC2 gene, resulting in a loss of function of either gene and subsequent increased activation of the mammalian target of rapamycin complex 1 (mTORC1).1 Activation of mTOR results in aberrant cellular proliferation and differentiation.3,4 This aberrant growth can r... | None disclosed. | |||||||
PMC10024406 | Drug-induced liver injury due to tofacitinib: a case report | Journal of Medical Case Reports | 2023-03-18 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024406/ | Background Drug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound.
Case presentation In the present work, liver failure following the use of tofacitinib was reported. The patient was an 18-year-old iranian woman without any history of underlying disease. ... | The liver plays an essential role in concentrating and metabolizing drugs. Many synthetic drugs, herbals, toxins, and even food supplements can lead to liver damage. This damage can occur immediately or months or years after taking the drug. In most cases, there is an increase in liver enzymes in the blood, which can b... | [
{
"section_type": "background",
"heading": "Background",
"text": "The liver plays an essential role in concentrating and metabolizing drugs. Many synthetic drugs, herbals, toxins, and even food supplements can lead to liver damage. This damage can occur immediately or months or years after taking the dr... | The liver plays an essential role in concentrating and metabolizing drugs. Many synthetic drugs, herbals, toxins, and even food supplements can lead to liver damage. This damage can occur immediately or months or years after taking the drug. In most cases, there is an increase in liver enzymes in the blood, which can b... | An 18-year-old iranian woman with anorexia and yellow discoloration of the conjunctiva and urine presentation was admitted to the Taleghani hospital in Tehran. At the time of admission, the patient had a stable condition but she was icteric and complained of loss of appetite for the last 2 weeks. Preliminary lab tests ... | Various factors can cause damage to the liver, such as infectious agents, toxins, autoimmunity, and drugs. Drug-induced liver injury (DILI) is the leading cause of acute liver. Age, gender, and pregnancy, as well as comorbidities such as obesity, diabetes, and underlying liver disease are outstanding risk factors for d... | ||||||||
PMC10024504 | Bilateral Upper Limb Complete Phocomelia: A Case Report | International Medical Case Reports Journal | 2023-03-14 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024504/ | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at | Introduction Phocomelia is an uncommon congenital condition in which the hand or foot are normal or almost normal but the proximal section of the limb – the humerus or femur, radius or tibia, ulna or fibula –_is missing or noticeably hypoplastic. It refers to how the patient’s limbs resemble marine creatures’ flippers ... | Phocomelia is an uncommon congenital condition in which the hand or foot are normal or almost normal but the proximal section of the limb – the humerus or femur, radius or tibia, ulna or fibula – is missing or noticeably hypoplastic . The hand or foot is directly linked to the trunk in true phocomelia, which is disting... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Phocomelia is an uncommon congenital condition in which the hand or foot are normal or almost normal but the proximal section of the limb – the humerus or femur, radius or tibia, ulna or fibula – is missing or noticeably hypoplastic . T... | Phocomelia is an uncommon congenital condition in which the hand or foot are normal or almost normal but the proximal section of the limb – the humerus or femur, radius or tibia, ulna or fibula – is missing or noticeably hypoplastic . The hand or foot is directly linked to the trunk in true phocomelia, which is disting... | We present a 15-min-old male neonate born to a para-four mother who did not remember her LNMP but claimed to be amenorrheic for the past nine months. His mother had antenatal care at the nearby health center twice and was uneventful. However, she had no early obstetric ultrasound. Otherwise, she has no history of chron... | Phocomelia is the absence of a large portion of the upper and/or lower limbs with preservation of the affected limb’s hands and/or feet.5 Frantz and O’Rahilly defined phocomelia as a type of intercalary failure of formation. Even though their classifications are simple, it has yet to be validated in practice.6 In phoco... | Phocomelia is a rare congenital anomaly in which the hand or foot are directly attached to the trunk. It is less severe form of Roberts syndrome and the patients with this condition can survive up to adulthood. Even though prenatal thalidomide exposure has been extensively linked with phocomelia alcohol intake, cigaret... | ||||||
PMC10024616 | Rare direct embolism of urothelial carcinoma causing acute mesenteric ischaemia during remission | Journal of Surgical Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024616/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( | Abstract Metastatic abdominal carcinomas have been reported in the literature to cause bowel ischaemia. However, these are often associated with diffuse disease or direct invasion of adjacent bowel secondary to high-grade malignancies. There are no reported cases of extensive small bowel wall nor arterial occlusion as ... | Urothelial carcinoma (UC) of the bladder may metastasise to the gastrointestinal tract at a rate of 3–5% and to the peritoneum at 16% in Stage IV disease [1, 2]. Manifestations of metastatic disease as the primary presenting symptom may be unexpected, especially amongst patients in remission for a prolonged period. Hos... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Urothelial carcinoma (UC) of the bladder may metastasise to the gastrointestinal tract at a rate of 3–5% and to the peritoneum at 16% in Stage IV disease [1, 2]. Manifestations of metastatic disease as the primary presenting symptom may... | Urothelial carcinoma (UC) of the bladder may metastasise to the gastrointestinal tract at a rate of 3–5% and to the peritoneum at 16% in Stage IV disease [1, 2]. Manifestations of metastatic disease as the primary presenting symptom may be unexpected, especially amongst patients in remission for a prolonged period. Hos... | The patient, who was in his early eighties, was admitted to the emergency department with severe abdominal pain and vomiting, on a background of multiple self-limiting episodes of similar pain for which no radiological or endoscopic causes had been identified. His past medical history included therapeutic anticoagulati... | Urothelial carcinoma, formerly known as transitional cell carcinoma, is the most common form of bladder cancer and has a high multiplicity rate . High-grade T1 (HGT1) bladder cancer is associated with a high recurrence rate and risk of progression thereby necessitating stringent endoscopic and radiological surveillance... | |||||||
PMC10025825 | Epithelioid Leiomyosarcoma of the Uterus and the Diagnostic Challenge in Diagnosing it on Small Biopsy | Journal of Mid-Life Health | 2022-01-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025825/ | This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identi... | Epithelioid leiomyosarcoma of the uterus is a rare soft-tissue tumor of the pelvis with <1% cases. It can be asymptomatic or can reach an enormous size, resulting in chronic pelvic pain, postmenopausal bleeding, or may cause bowel and bladder dysfunction. The diagnostic dilemma arises especially when they have epitheli... | Leiomyosarcoma of the uterus is a rare soft-tissue tumor of the female pelvis with <1% of uterine tumor. It usually arises from the uterine myometrium de novo or is very rarely transformed from a preexisting benign leiomyoma. These tumors are found mainly in females 40–60 years of age. Leiomyomas are commonly seen in t... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Leiomyosarcoma of the uterus is a rare soft-tissue tumor of the female pelvis with <1% of uterine tumor. It usually arises from the uterine myometrium de novo or is very rarely transformed from a preexisting benign leiomyoma. These tumo... | Leiomyosarcoma of the uterus is a rare soft-tissue tumor of the female pelvis with <1% of uterine tumor. It usually arises from the uterine myometrium de novo or is very rarely transformed from a preexisting benign leiomyoma. These tumors are found mainly in females 40–60 years of age. Leiomyomas are commonly seen in t... | A 46-year-old postmenopausal female presented to the gynecology outpatient department at our hospital with symptoms of postmenopausal bleeding for the past 3 months along with abdominal obstruction. There was a history of significant weight loss and loss of appetite. There were no bladder or bowel complaints. Ultrasoun... | According to the 2020 WHO classification, uterine sarcoma consists of leiomyosarcoma, low- and high-grade endometrial stromal sarcoma, and undifferentiated sarcoma. Epithelioid leiomyosarcomas have very rarely been reported in the literature and can be very unpredictable. They can remain dormant for long periods or rec... | Uterine epithelioid leiomyosarcoma is a very rare and aggressive sarcoma of the uterus. It is difficult to diagnose on microscopy alone at times and a panel of IHCS especially the additional IHCs such as WT1, P53, CD117, and p16 are helpful where molecular investigations are not feasible. WT1 has diagnostic as well as ... | The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due ef... | |||||
PMC10026124 | Idiopathic pyostomatitis-pyodermatitis vegetans with nasal
obstruction: A case report | SAGE Open Medical Case Reports | 2023-03-18 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026124/ | This article is distributed under the terms of the Creative Commons
Attribution-NonCommercial 4.0 License ( | Pyostomatitis-pyodermatitis vegetans is an uncommon mucocutaneous dermatosis of
unknown etiology. It presents as erythematous pustules that coalesce to form
exudative vegetating plaques on the oral mucosa and/or skin. Diagnosis is
largely based on clinical assessment, although histopathology should be used as
supportin... | Pyostomatitis-pyodermatitis vegetans (PSV-PDV) is a rare and chronic mucocutaneous
dermatosis initially described by Hallopeau in 1898, yet it remains poorly
understood today.1 PSV-PDV is clinically characterized by multiple erythematous
pustules that coalesce into well-defined exudative vegetating plaques with
charact... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Pyostomatitis-pyodermatitis vegetans (PSV-PDV) is a rare and chronic mucocutaneous\ndermatosis initially described by Hallopeau in 1898, yet it remains poorly\nunderstood today.1 PSV-PDV is clinically characterized by multiple erythemat... | Pyostomatitis-pyodermatitis vegetans (PSV-PDV) is a rare and chronic mucocutaneous
dermatosis initially described by Hallopeau in 1898, yet it remains poorly
understood today.1 PSV-PDV is clinically characterized by multiple erythematous
pustules that coalesce into well-defined exudative vegetating plaques with
charact... | A 48-year-old male auto mechanic presented with a 3-month history of expanding eroded
plaques involving his upper lip and anterior nares bilaterally. This resulted in
nasal obstruction, difficulty breathing, and an inability to work. He was previously
well with no significant medical history including immunodeficiencie... | The etiology of PSV-PDV remains poorly understood and there is a wide differential
diagnosis.1,2
This should include deep fungal or mycobacterial infections, halogenodermas,
pyoderma gangrenosum, pemphigus vegetans, granulomatosis with polyangiitis, and
cutaneous B- and T-cell lymphomas.2,4 A skin biopsy including cult... | |||||||
PMC10028247 | Eosinophilic fasciitis following SARS-CoV-2 vaccination | JAAD Case Reports | 2023-06-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028247/ | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-re... | Eosinophilic fasciitis (EF) is a rare scleroderma-like syndrome considered to be an autoimmune disease.1
,
2 It was first described by Shulman3 in 1974, and is characterized by induration of the skin, peripheral eosinophilia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate. The disorder occurs equal... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Eosinophilic fasciitis (EF) is a rare scleroderma-like syndrome considered to be an autoimmune disease.1\n,\n2 It was first described by Shulman3 in 1974, and is characterized by induration of the skin, peripheral eosinophilia, hypergam... | Eosinophilic fasciitis (EF) is a rare scleroderma-like syndrome considered to be an autoimmune disease.1
,
2 It was first described by Shulman3 in 1974, and is characterized by induration of the skin, peripheral eosinophilia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate. The disorder occurs equal... | A 55-year-old White man with medical history of dyslipidemia presented with abrupt painful swelling of the trunk and 4 extremities, arthralgia, and limited joint mobility of the wrists. The patient did not have any allergies, and no previous trauma or strenuous exercise was reported. He did acknowledge having received ... | EF is a rare scleroderma-like syndrome. The differential diagnosis of this entity includes localized scleroderma and systemic sclerosis, as well as other scleroderma-like disorders, such as nephrogenic systemic fibrosis, scleromyxedema, eosinophilia-myalgia, or graft-versus-host disease.2
,
4
,
6
The pathophysiology o... | None disclosed. | |||||||
PMC10029247 | Scurvy, abnormal MRI, and gelatinous bone marrow in an adolescent with avoidant restrictive food intake disorder | Journal of Eating Disorders | 2023-03-20 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029247/ | Background Although medical literature describes pediatric scurvy as “rare”, a growing number of case reports suggests otherwise. Patients often undergo costly and unnecessary workup due to unfamiliarity with the presentation of scurvy. This case report further supports the small yet growing literature documenting scur... | Currently, scurvy is thought of as “rare” and irrelevant to patients in developed countries. Many providers are unfamiliar with the presentation of scurvy. We present a case of an adolescent with an eating disorder who, despite having classic features of scurvy, underwent a lengthy and extensive workup. Her case is not... | [
{
"section_type": "background",
"heading": "Background",
"text": "Currently, scurvy is thought of as “rare” and irrelevant to patients in developed countries. Many providers are unfamiliar with the presentation of scurvy. We present a case of an adolescent with an eating disorder who, despite having cla... | Currently, scurvy is thought of as “rare” and irrelevant to patients in developed countries. Many providers are unfamiliar with the presentation of scurvy. We present a case of an adolescent with an eating disorder who, despite having classic features of scurvy, underwent a lengthy and extensive workup. Her case is not... | A 15-year-old female with history of mild depression presented to the emergency department with acutely worsening bilateral knee pain, rash, easy bruising, and fatigue. She noticed the bilateral leg rash seven years ago (which she kept hidden from her parents). In the preceding two months, a rash formed on her wrists, ... | Publications on pediatric scurvy have increased in recent years. These include diverse subspecialities including radiology, orthopedics, and developmental pediatrics. One developmental pediatrics review identified 20 reports involving 24 children with autism and ARFID who developed scurvy . An institutional orthopedic ... | In conclusion, clinicians should keep scurvy on the differential of patients with malnutrition presenting with multisystem findings including anemia, fever, rash, joint swelling, or abnormal radiology findings. Specifically, clinicians who work with patients with eating disorders may need to have a heightened index of ... | The patient recently was asked for a statement regarding her opinion on her care received. She commented mainly on her inpatient eating disorder facility stay, which was after the events of the case report. She stated “Not to say that the care I received was bad, but I felt like a lot my care wasn’t designed for someon... | ||||||
PMC10030103 | Left diaphragmatic hernia after a mild blunt trauma in Syria: a case report | Journal of Surgical Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030103/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( | Abstract Left side traumatic diaphragmatic hernias (DH) are very rare and usually present acutely. They might represent after years of minor trauma, and they should be considered among differentials to avoid complications. We present a 28-year-old female coming with acute epigastric pain radiating into the chest with d... | Traumatic injury to the diaphragm is relatively uncommon, with an incidence between 0.8 and 8% . We present a young female who had acute abdominal pain and dyspnea. No significant history of trauma was found that highlights the importance of keeping diaphragmatic hernia (DH) among differential diagnosis of unexplained ... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Traumatic injury to the diaphragm is relatively uncommon, with an incidence between 0.8 and 8% . We present a young female who had acute abdominal pain and dyspnea. No significant history of trauma was found that highlights the importan... | Traumatic injury to the diaphragm is relatively uncommon, with an incidence between 0.8 and 8% . We present a young female who had acute abdominal pain and dyspnea. No significant history of trauma was found that highlights the importance of keeping diaphragmatic hernia (DH) among differential diagnosis of unexplained ... | A 28-year-old housewife who presented with dyspnea and vomiting for one week, with epigastric pain radiating into the chest. She had no fever, cough or hemoptysis. She had no significant history for cardiac or pulmonary disease, and she was a non-smoker. She did not take any medication, including oral contraceptive pil... | The exact incidence of DHs is difficult to determine, given that many cases are asymptomatic and go undiagnosed. Furthermore, the incidence of blunt versus penetrating trauma is widely variable [1–3]. Males between 30 and 45 years have the highest prevalence of traumatic DHs [1–3]. Left DHs are more common compared to ... | Traumatic diaphragmatic hernias are rare and can be caused by relatively minor trauma that might be direct or indirect. This can occur even years after the initial trauma. Early diagnosis and management of symptomatic causes is crucial to avoid serious complications. | ||||||
PMC10030809 | Imaging modalities used in mammary fibromatosis | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030809/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Mammary fibromatosis is a rare neoplastic proliferation of fibroblastic cells. Usually seen in abdominal and extra-abdominal sites, it is rarely seen in the breast. Patients with mammary fibromatosis usually present with a firm palpable mass with or without dimpling and skin retraction–often mimicking breast carcinoma.... | Breast fibromatosis; although lacking metastasizing potential, is an aggressive neoplastic proliferation of fibroblastic cells. This is seen in the abdominal wall and extra-abdominal sites but is rarely seen in the breast (1). Although breast fibromatosis may arise after surgical trauma or silicone implant insertion, t... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Breast fibromatosis; although lacking metastasizing potential, is an aggressive neoplastic proliferation of fibroblastic cells. This is seen in the abdominal wall and extra-abdominal sites but is rarely seen in the breast (1). Although ... | Breast fibromatosis; although lacking metastasizing potential, is an aggressive neoplastic proliferation of fibroblastic cells. This is seen in the abdominal wall and extra-abdominal sites but is rarely seen in the breast (1). Although breast fibromatosis may arise after surgical trauma or silicone implant insertion, t... | A 49-year-old woman presented to the breast care unit of Letterkenny University Hospital with a palpable lump in her right breast which she had noticed 3 months earlier. Her previous visit to the breast care unit was 2 years prior for 2 separate lumps on her left breast–2-o'clock position, which were fibroadenomas–visi... | Desmoid type fibromatosis is a rare locally infiltrative soft tissue tumor that lacks metastatic potential. Arising from fibroblasts or myofibroblasts; it is known to occur within the breast parenchyma but is more commonly found arising from the fascia of the pectoralis and extending into the breast . It is usually fou... | Informed consent was obtained from the patient for the purposes of the publication of this case report. | ||||||
PMC10030818 | Kimura disease forming a human polyomavirus 6–negative parotid gland nodule with prominent squamous metaplasia in a young female: A case report | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030818/ | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | A case of an asymptomatic 19-year-old woman with Kimura disease presenting with a nodule in the right parotid gland is presented. She had a medical history of atopic dermatitis and noticed a mass on her right-side neck. Cervical lymphadenopathy was clinically diagnosed. The initial management plan was to observe the le... | Kimura disease (KD) is a chronic inflammatory disease that commonly affects young Asian males. The clinical features of KD are characterized by blood eosinophilia, increased serum immunoglobulin E (IgE) levels, and head and neck lesions involving subcutaneous tissue, salivary glands, and/or single or multiple regional ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Kimura disease (KD) is a chronic inflammatory disease that commonly affects young Asian males. The clinical features of KD are characterized by blood eosinophilia, increased serum immunoglobulin E (IgE) levels, and head and neck lesions... | Kimura disease (KD) is a chronic inflammatory disease that commonly affects young Asian males. The clinical features of KD are characterized by blood eosinophilia, increased serum immunoglobulin E (IgE) levels, and head and neck lesions involving subcutaneous tissue, salivary glands, and/or single or multiple regional ... | This case report presents a young female with KD showing unilateral parotid gland involvement. The lesion in this case was clinically identified as cervical lymphadenopathy. KD usually affects the subcutaneous tissue and regional lymph nodes, predominantly in the head and neck region . Interestingly, our case showed th... | A 19-year-old nulliparous woman was referred to our hospital because of a swollen, slightly painful mass in the submandibular region of the right-side neck. She had a history of atopic dermatitis but no history of surgery or treatment for any other disease. She was not taking any medication. The patient's family histor... | |||||||
PMC10030823 | A case of intravascular lymphoma presenting with a lesion in the splenium of the corpus callosum | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030823/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Intravascular lymphoma (IVL) is difficult to diagnose because its clinical presentation and laboratory and imaging findings are nonspecific. Herein, we report a case of IVL presenting as a lesion in the splenium of the corpus callosum. A 52-year-old man attended the emergency department with a 2-week history of progres... | Intravascular lymphoma (IVL) is a rare form of large B-cell non-Hodgkin's lymphoma that is prone to the central nervous system (CNS) vascular invasion and occlusion, often resulting in non-localized neuropathy and altered mental status . The diagnosis of IVL is challenging because its clinical presentation and laborato... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Intravascular lymphoma (IVL) is a rare form of large B-cell non-Hodgkin's lymphoma that is prone to the central nervous system (CNS) vascular invasion and occlusion, often resulting in non-localized neuropathy and altered mental status ... | Intravascular lymphoma (IVL) is a rare form of large B-cell non-Hodgkin's lymphoma that is prone to the central nervous system (CNS) vascular invasion and occlusion, often resulting in non-localized neuropathy and altered mental status . The diagnosis of IVL is challenging because its clinical presentation and laborato... | A previously healthy 52-year-old Asian man attended the emergency department with a 2-week history of progressively worsening abnormal behavior and gait disturbance. Nonenhanced brain magnetic resonance imaging (MRI) performed on admission revealed an oval lesion in the splenium of the corpus callosum. It showed hyperi... | Lesions in the splenium of the corpus callosum are seen in various diseases . Diseases that present with lesions in the splenium of the corpus callosum include traumatic lesions (diffuse axonal injury), ischemic lesions (infarction, hypoxic-Ischemic encephalopathy, hypoglycemic encephalopathy), tumors (lymphoma, glioma... | A consent was obtained from the patient's family for publication of this report. | ||||||
PMC10033794 | Acute myocarditis during adjuvant therapies for breast cancer: a case report | Surgical Case Reports | 2023-03-23 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033794/ | Background With the improvement of optimal perioperative drug therapy for breast cancer patients, physicians now have to treat the adverse effects and comorbidities associated with long-term treatments. We report a case who suffered cardiac arrest due to acute myocarditis developed after initiation of adjuvant treatmen... | The outcome for early stage breast cancer (EBC) patients is continually being improved by optimal perioperative drug therapy. This is particularly evident in patients with estrogen receptor (ER)-positive disease, which accounts for the majority of breast cancers [1, 2]. However, physicians are now increasingly having t... | [
{
"section_type": "background",
"heading": "Background",
"text": "The outcome for early stage breast cancer (EBC) patients is continually being improved by optimal perioperative drug therapy. This is particularly evident in patients with estrogen receptor (ER)-positive disease, which accounts for the ma... | The outcome for early stage breast cancer (EBC) patients is continually being improved by optimal perioperative drug therapy. This is particularly evident in patients with estrogen receptor (ER)-positive disease, which accounts for the majority of breast cancers [1, 2]. However, physicians are now increasingly having t... | A 46-year-old female patient was previously diagnosed with breast cancer (right breast, cT2N1M0 Stage IIB, invasive ductal carcinoma, ER-positive, HER2-positive) at the age of 44. After initially completing preoperative chemotherapy (anthracycline and taxane plus anti-HER2 therapy), the patient underwent curative surge... | Since this patient developed hepatic dysfunction relatively early after the administration of TAM, it was initially assumed that the patient had developed drug-induced fulminant hepatitis. However, it became evident this severe liver dysfunction was caused by blood congestion due to myocarditis.
Drug-induced, congesti... | We report a case with strong indications for therapy-induced liver damage, after starting TAM and resumption of trastuzumab, who was ultimately diagnosed with acute viral myocarditis. This patient was successfully treated with multidisciplinary therapy. During drug treatment, it is necessary to take a broad view and di... | |||||||
PMC10034269 | Facial eccrine angiomatous hamartoma in a 52-year-old woman: A case
report | SAGE Open Medical Case Reports | 2023-03-21 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034269/ | This article is distributed under the terms of the Creative Commons
Attribution-NonCommercial 4.0 License ( | Eccrine angiomatous hamartoma is a rare, benign condition. Patients typically
present with a solitary, sometimes enlarging nodule of the extremities usually
appearing at birth or arising during childhood. Eccrine angiomatous hamartoma is
usually sporadic, but one familial case of the multifocal variant has been
reporte... | Eccrine angiomatous hamartoma (EAH) is a rare, benign malformation that is usually
congenital or prepubertal and there is no preference related to patients’ sex. It
presents as a solitary flesh-colored lesion, either asymptomatic or causing mild
pain, and hyperhidrosis on extremities. Enlargement typically occurs comme... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Eccrine angiomatous hamartoma (EAH) is a rare, benign malformation that is usually\ncongenital or prepubertal and there is no preference related to patients’ sex. It\npresents as a solitary flesh-colored lesion, either asymptomatic or c... | Eccrine angiomatous hamartoma (EAH) is a rare, benign malformation that is usually
congenital or prepubertal and there is no preference related to patients’ sex. It
presents as a solitary flesh-colored lesion, either asymptomatic or causing mild
pain, and hyperhidrosis on extremities. Enlargement typically occurs comme... | A previously healthy 52-year-old woman presented to the clinic with a lesion on the
chin. She reported that the lesion started as pinkish plaques 7 years ago. The
lesion slowly enlarged and became tender to touch. The color changed from pink to
purple with overlying telangiectasia and increased perspiration associated ... | EAH is a rare, benign condition that is usually congenital or arises during
prepubertal years,1 though it has also been reported in older patients.2 Our case
involves a 52-year-old woman presenting with EAH. The unusual location of EAH in
this case and the paucity of its mention in the literature prompted us to report
... | |||||||
PMC10034294 | Primary syphilis with a tongue ulcer mimicking tongue cancer: a case
report | The Journal of International Medical Research | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034294/ | Creative Commons Non Commercial CC BY-NC: This article is distributed
under the terms of the Creative Commons Attribution-NonCommercial 4.0
License ( | The main symptom in primary syphilis is a small, painless, sore or ulcer called a
chancre on the penis, vagina, or around the anus, although chancres can
sometimes appear in the mouth or on the lips, fingers, or buttocks. We present
the case of a man in his early 60 s with a chief complaint of a painful tongue
ulcer. A... | Syphilis is a systemic infectious disease caused by Treponema
pallidum (T. pallidum) and a major sexually
transmitted disease (STD).1 The main symptom in primary syphilis is a small, painless,
sore or ulcer called a chancre on the penis, vagina, or around the anus, although
lesions can sometimes appear in the mouth or ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Syphilis is a systemic infectious disease caused by Treponema\npallidum (T. pallidum) and a major sexually\ntransmitted disease (STD).1 The main symptom in primary syphilis is a small, painless,\nsore or ulcer called a chancre on the pe... | Syphilis is a systemic infectious disease caused by Treponema
pallidum (T. pallidum) and a major sexually
transmitted disease (STD).1 The main symptom in primary syphilis is a small, painless,
sore or ulcer called a chancre on the penis, vagina, or around the anus, although
lesions can sometimes appear in the mouth or ... | A man in his early 60 s visited our hospital with a chief complaint of pain on the
left edge of his tongue. He had a history of type 2 diabetes and took oral
ipragliflozin L-proline. He had no particular family history and did not drink
alcohol. He had a smoking history of 60 cigarettes/day for 37 years from age 20, bu... | The lesion in our patient was diagnosed as tongue cancer owing to the refractory
tongue ulcer and surrounding induration, with lymph node swelling found by
inspection and palpation during the first physical examination. The cervical lymph
node swelling was suspected cervical lymph node metastasis. However, swelling in
... | There has recently been a marked increase in the number of patients with syphilis in
Japan. Thus, syphilis should not be considered a forgotten disease, but instead,
should be diagnosed using serological tests in suspected cases. We suggest that
dentists consider syphilis as a differential diagnosis for oral refractory... | Research Data for Primary syphilis with a tongue ulcer mimicking tongue
cancer: a case reportClick here for additional data file.Research Data for Primary syphilis with a tongue ulcer mimicking tongue cancer: a
case report by Chonji Fukumoto, Manabu Zama, Toshiki Hyodo, Ryo Shiraishi,
Ryouta Kamimura, Shuma Yagisawa, T... | |||||
PMC10034391 | Relapsed chronic lymphocytic leukemia with a cardiac mass: A case report | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034391/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in the USA. Extra-medullary disease is very rare and is not well characterized. In practice, clinically significant cardiac or pericardial involvement by CLL is extremely rare with only a few case reports in literature. We report a 51-year-o... | Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in the United States . It is more prevalent in elderly males and commonly presents with a relatively benign course. Extra-medullary disease is very rare and is not well characterized. It suggests a more aggressive disease and warrants a high... | [
{
"section_type": "background",
"heading": "Background",
"text": "Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in the United States . It is more prevalent in elderly males and commonly presents with a relatively benign course. Extra-medullary disease is very rare and is... | Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in the United States . It is more prevalent in elderly males and commonly presents with a relatively benign course. Extra-medullary disease is very rare and is not well characterized. It suggests a more aggressive disease and warrants a high... | A 51-year-old male patient presented with fatigue, shortness of breath, dry cough, and night sweats of 1-month duration. He reported that his dyspnea was mainly on exertion but also when sleeping on his right side and was associated with palpitations. He also noticed a painless lump on the left side of his neck 1 week ... | CLL is the most common leukemia in the west and is characterized by monoclonal B cell proliferation in the blood, bone marrow and lymphoid tissue . The presentation of a CLL patient with a large cardiac mass is very rare and only noted a few times in previous case reports. The differential diagnosis of this cardiac mas... | This case represents one of the few known cases of cardiac EM-CLL in a patient presenting with a huge cardiac mass in the right atrium and right ventricle. Further studies are needed to characterize the course of the disease, prognosis and optimum management along with the role of surgery. | Informed written consent obtained from patient.
AM: Data acquisition, literature review. AA: Data acquisition. MM: literature review, manuscript writing. MS: Cardiology review, manuscript writing. ZA: Hematology review. RR: Clinical management, Manuscript review.
For this type of study formal consent is not required | |||||
PMC10034423 | Gastric outlet obstruction caused by heterotopic pancreas in a patient with alcohol use disorder | International Journal of Surgery Case Reports | 2023-04-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034423/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Introduction and importance Heterotopic Pancreas (HP) is defined by the presence of pancreatic tissue in an anatomically distinct location from the main pancreas. While often clinically silent, it may present symptomatically. If located in the gastric antrum, HP may cause gastric outlet obstruction (GOO). The objective... | 1
Heterotopic pancreas (HP), also known as ectopic pancreas, is a rare congenital condition wherein pancreatic tissue exists in an anatomically distinct location from the true pancreas . The incidence rate on autopsy ranges from 0.5 % to 13.7 % . HP can occur in various gastrointestinal organs including the stomach an... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "1\n\nHeterotopic pancreas (HP), also known as ectopic pancreas, is a rare congenital condition wherein pancreatic tissue exists in an anatomically distinct location from the true pancreas . The incidence rate on autopsy ranges from 0.5 ... | 1
Heterotopic pancreas (HP), also known as ectopic pancreas, is a rare congenital condition wherein pancreatic tissue exists in an anatomically distinct location from the true pancreas . The incidence rate on autopsy ranges from 0.5 % to 13.7 % . HP can occur in various gastrointestinal organs including the stomach an... | 3
HP is a congenital condition, with the most common developmental cause believed to be heteroplastic differentiation of endodermal tissue in sites where pancreatic tissue does not normally develop, particularly gastric submucosa . In our case, the submucosal layer of the gastric antrum was partially involved.
Since ... | 4
Even though HP is rare, it is relevant to include in the differential diagnosis of a patient presenting with GOO. HP maybe visualized as a mass and mistaken for malignancy. It is pertinent to further study and report such cases to develop more specific guidelines for diagnosis and treatment. | 2
A 43-year-old man presented to the emergency department (ED) in July 2022 with 8 days of persistent vomiting with occasional abdominal pain following heavy alcohol use. Prior to this presentation, he had been seen in an urgent care clinic and the ED for epigastric abdominal pain and emesis. He reported that he was a... | ||||||
PMC10034566 | Fat emboli and critical illness-associated cerebral microbleeds (CICMs) in a patient with sickle cell disease: Do these 2 entities coexist? | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034566/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | We report the case of a 30-year-old female patient with sickle cell disease presenting with an acute chest syndrome and neurological deterioration. Cerebral magnetic resonance imaging revealed a handful of foci of diffusion restriction and numerous microbleeds with marked involvement of corpus callosum and subcortical ... | We report the case of a 30-year-old homozygous sickle cell disease (SCD) female with respiratory failure and neurological deterioration complicating a vaso-occlusive crisis. The patient was admitted to the intensive care unit (ICU) of our institution as a transfer from an outside hospital.
The patient had presented wi... | [
{
"section_type": "case_presentation",
"heading": "Case report",
"text": "We report the case of a 30-year-old homozygous sickle cell disease (SCD) female with respiratory failure and neurological deterioration complicating a vaso-occlusive crisis. The patient was admitted to the intensive care unit (ICU... | We report the case of a 30-year-old homozygous sickle cell disease (SCD) female with respiratory failure and neurological deterioration complicating a vaso-occlusive crisis. The patient was admitted to the intensive care unit (ICU) of our institution as a transfer from an outside hospital.
The patient had presented wi... | The term cerebral microbleeds (CMB) refers to small deposits of chronic blood products in normal or near-normal brain which appear as punctate foci of low signal intensity on MRI sequences that are sensitive to susceptibility effects. These low signal dots have been proven to correspond to clusters of perivascular hemo... | We have a written and informed consent from the patient. | |||||||
PMC10035546 | Isolated Internal Ophthalmoplegia from Posterior Cerebral Artery Neurovascular Conflict | Case Reports in Ophthalmology | 2023-03-22 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035546/ | This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) ( | Abstract We report a rare case of recurrent isolated internal ophthalmoplegia attributed to oculomotor nerve (CN III) compression by the posterior cerebral artery (PCA). A 30-year-old female patient presented with recurrent right-sided headaches, right periorbital pain, and slight anisocoria. Slit-lamp examination reve... | Oculomotor nerve (CN III) palsy, particularly with isolated internal ophthalmoplegia, is a medical emergency because compression from arterial aneurysm must be ruled out. CN III originates between the midbrain and pons at the level of the superior colliculus with its root exit zone at the medial aspect of the cerebral ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Oculomotor nerve (CN III) palsy, particularly with isolated internal ophthalmoplegia, is a medical emergency because compression from arterial aneurysm must be ruled out. CN III originates between the midbrain and pons at the level of t... | Oculomotor nerve (CN III) palsy, particularly with isolated internal ophthalmoplegia, is a medical emergency because compression from arterial aneurysm must be ruled out. CN III originates between the midbrain and pons at the level of the superior colliculus with its root exit zone at the medial aspect of the cerebral ... | A 30-year-old, otherwise healthy, female patient presented to our emergency department complaining of recurrent right periorbital pain and right-sided intermittent headache over the past year at least twice per month, lasting a couple of hours, occasionally with nausea but without visual symptoms. She also reported a f... | CN III disorders can be caused by a variety of anatomic or medical conditions including compression from aneurysms, trauma, neoplasms, post-neurosurgical conditions, diabetes mellitus, hypertension, post-viral infections, ophthalmoplegic migraine, and inflammations associated with ischemia . Depending on the cause and ... | Ethical approval is not required for this study in accordance with local or national guidelines. Written informed consent was obtained from the patient for publication of the details of their medical case and any accompanying images in this manuscript.
The authors have no conflicts of interest to declare.
No funding ... | ||||||
PMC10036072 | Primary Pancreatic Undifferentiated Pleomorphic Sarcoma | ACG Case Reports Journal | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036072/ | This is an open access article distributed under the terms of the | ABSTRACT Primary pancreatic sarcomas are rare malignancies with an incidence of 0.1%. This case report is of a 48-year-old man who presented with this condition. The patient's treatment plan consisted of distal pancreatectomy and splenectomy with intraoperative immunohistochemistry and adjuvant chemotherapy. To correct... | Abdominal pain is a common presenting symptom of pancreatic malignancy related to neurovisceral irritation.1 Primary pancreatic sarcomas with an incidence of 0.1% often present with abdominal pain. The term “sarcoma” refers to a diverse group of malignancies that originate in the soft tissues and bones. We report a cas... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Abdominal pain is a common presenting symptom of pancreatic malignancy related to neurovisceral irritation.1 Primary pancreatic sarcomas with an incidence of 0.1% often present with abdominal pain. The term “sarcoma” refers to a diverse... | Abdominal pain is a common presenting symptom of pancreatic malignancy related to neurovisceral irritation.1 Primary pancreatic sarcomas with an incidence of 0.1% often present with abdominal pain. The term “sarcoma” refers to a diverse group of malignancies that originate in the soft tissues and bones. We report a cas... | A 48-year-old man presented to the emergency department with nonradiating, left lower quadrant abdominal pain for 2 days. The pain was aggravated by ingestion of food and accompanied by low-grade fever, malaise, loose stool, and 10 lbs. weight loss over 3 months. He denied nausea, emesis, melena, jaundice, recent traum... | Primary UPS is an exceptionally rare subtype of pancreatic sarcoma.2 Pancreatic sarcomas are aggressive and are often associated with poor prognosis.3 The first case of pancreatic UPS was reported in 1986, which had good outcome with only distal pancreatectomy and splenectomy without radiotherapy or chemotherapy.4 Ambe... | Author contributions: MH Patel: drafted the case; presented the case in a national meeting; and wrote, revised, and edited the manuscript. D. Guerrero Vinsard: case concept, case report supervision, and critically revised and edited the manuscript. U. Agrawal: cowrote, critically revised, and edited the manuscript. RW ... | ||||||
PMC10036178 | Postictal Psychosis: Case Report and Literature Review | Case Reports in Psychiatry | 2023-01-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036178/ | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | Postictal psychosis (PIP) is one of the most common types of psychosis in epileptic patients. By virtue of the paucity of research on PIP, its pathophysiology remains not completely understood. Our case report describes a clinical picture of PIP, characterized by pleomorphic features, with neither Schneider's first - r... | Patients with a long-standing history of seizures are more susceptible to developing major psychiatric disorders, including epileptic psychosis . Psychotic syndromes associated with epilepsy are most seen in patients with longstanding epilepsy with a pharmacoresistant profile or in epileptic patients who are nonadheren... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Patients with a long-standing history of seizures are more susceptible to developing major psychiatric disorders, including epileptic psychosis . Psychotic syndromes associated with epilepsy are most seen in patients with longstandin... | Patients with a long-standing history of seizures are more susceptible to developing major psychiatric disorders, including epileptic psychosis . Psychotic syndromes associated with epilepsy are most seen in patients with longstanding epilepsy with a pharmacoresistant profile or in epileptic patients who are nonadheren... | A 44-year-old female patient, without a personal or family history of psychiatric illness, was admitted to a psychiatric ward for a psychotic episode which has started three days before, characterized by perplexity, self-referent and mystical delusions, irritability, disorganized behavior, and aggressiveness, that had ... | Regarding the approach to the evaluation of an epileptic patient with an acute psychosis emerging during the postictal period, performing an EEG during the psychotic symptoms is relevant to rule out an ongoing epileptiform activity or a nonconvulsive status epilepticus, which could account for the diagnosis of ictal ps... | |||||||
PMC10037294 | Sclerosing odontogenic carcinoma of maxilla: A case report | World Journal of Clinical Cases | 2023-03-16 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037294/ | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commerciall... | BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017, with only 14 cases published to date. The biological characteristics of sclerosing odontogenic carcinoma remain ... | Core Tip: Sclerosing odontogenic carcinoma is a rare disease entity with only 14 cases published to date, this case report will further substantiate the understanding to this disease and the management protocols.
Sclerosing odontogenic carcinoma (SOC) is an unusual primary intraosseous neoplasm that was added to the 4... | [
{
"section_type": "other",
"heading": "",
"text": "Core Tip: Sclerosing odontogenic carcinoma is a rare disease entity with only 14 cases published to date, this case report will further substantiate the understanding to this disease and the management protocols."
},
{
"section_type": "backgroun... | Sclerosing odontogenic carcinoma (SOC) is an unusual primary intraosseous neoplasm that was added to the 4th edition World Health Organization (WHO) classification of Head and Neck Tumors in 2017. This disease entity was first described by Landwehr and Allen in 1996 and subsequently reported by Koutlas et al in 2008. N... | Initial clinical examination revealed a firm mass over the anterior palate, without apparent buccal and lingual expansion. The initial dental panoramic tomogram (DPT) revealed radiolucency with a welldefined sclerotic border of the right maxilla extending into the right maxillary sinus and significant root resorption o... | Right subtotal maxillectomy and reconstruction with a vascularized free fibula flap were performed under the guidance of an intraoperative navigation system (BrainLAB, AG, Feldkirchen, Germany). Approximately 1.5 cm surgical margins were resected, guided by the intraoperative navigation system, to ensure clear surgical... | SOC is a relatively rare and disputable entity that was recently featured in the 2017 WHO classification of Head and Neck Tumours. Despite its recent addition to the WHO classification and its locally aggressive nature, the characteristics and treatment protocol for SOC are inadequately described because of its scarcit... | In summary, the biological behaviors, and characteristics of SOC remain ambiguous owing to its rarity, with limited case reports published to date. More cases are needed to further characterize this entity, understand its biological behavior, and justify the treatment protocols. To date, surgical resection with adequat... | Core Tip: Sclerosing odontogenic carcinoma is a rare disease entity with only 14 cases published to date, this case report will further substantiate the understanding to this disease and the management protocols.
A 62-year-old woman presented to her local hospital in December 2017 with a 7-year history of right palata... | ||||
PMC10037891 | Late infantile form of multiple sulfatase deficiency with a novel missense variant in the SUMF1 gene: case report and review | BMC Pediatrics | 2023-03-24 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037891/ | Background Multiple sulfatase deficiency (MSD) is a rare lysosomal storage disorder caused due to pathogenic variants in the SUMF1 gene. The SUMF1 gene encodes for formylglycine generating enzyme (FGE) that is involved in the catalytic activation of the family of sulfatases. The affected patients present with a wide sp... | Multiple sulfatase deficiency (MSD) (OMIM#272200) is a rare lysosomal storage disorder with an incidence of 1 in 1.4 million newborns . It occurs due to a defect in the SUMF1 gene, located on chromosome 3p26.1, that encodes for formylglycine generating enzyme (FGE) [2–4]. FGE is involved in the posttranslational modifi... | [
{
"section_type": "background",
"heading": "Background",
"text": "Multiple sulfatase deficiency (MSD) (OMIM#272200) is a rare lysosomal storage disorder with an incidence of 1 in 1.4 million newborns . It occurs due to a defect in the SUMF1 gene, located on chromosome 3p26.1, that encodes for formylglyc... | Multiple sulfatase deficiency (MSD) (OMIM#272200) is a rare lysosomal storage disorder with an incidence of 1 in 1.4 million newborns . It occurs due to a defect in the SUMF1 gene, located on chromosome 3p26.1, that encodes for formylglycine generating enzyme (FGE) [2–4]. FGE is involved in the posttranslational modifi... | Case 1: A male child born to a second-degree consanguineous Muslim couple from Ahmedabad, Gujarat presented at our clinic at 6 years of age 1A).1Case 1. A: Pedigree chart, proband is shown by arrow, B: Clinical photograph of the proband showing no facial dysmorphism, C: MRI of the proband showing mild thinning of poste... | MSD is an ultra-rare lysosomal storage disorder characterized by a deficiency of the FGE protein. The key presenting features of MSD are neurological complications, developmental delay, skeletal and dermatological abnormalities . Of these, ichthyosis is the most frequently reported sign (~ 71% cases) followed by organo... | ||||||||
PMC10038694 | Idiopathic systemic capillary leak syndrome: a case report | BMC Nephrology | 2023-03-25 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038694/ | Background Idiopathic systemic capillary leak syndrome (ISCLS) is a rare disease characterized by recurrent episodes of acute life-threatening attacks of shock, hemoconcentration, and hypoalbuminemia. Increase in capillary permeability results in reversible plasma movement into the interstitial spaces followed by appea... | Idiopathic systemic capillary leak syndrome (ISCLS) is a rare and fatal disease, first described by Clarkson in 1960. The first case of ISCLS was reported in a 32-year-old woman who experienced periodic sudden and unexplained movement of plasma from intravascular compartment to interstitial space due to increased capil... | [
{
"section_type": "background",
"heading": "Background",
"text": "Idiopathic systemic capillary leak syndrome (ISCLS) is a rare and fatal disease, first described by Clarkson in 1960. The first case of ISCLS was reported in a 32-year-old woman who experienced periodic sudden and unexplained movement of ... | Idiopathic systemic capillary leak syndrome (ISCLS) is a rare and fatal disease, first described by Clarkson in 1960. The first case of ISCLS was reported in a 32-year-old woman who experienced periodic sudden and unexplained movement of plasma from intravascular compartment to interstitial space due to increased capil... | A 47-year-old man was admitted to our hospital after presenting to the emergency department in March 2017, with complaints of general weakness, lower back pain and abdominal pain that started on the same day. The patient had no underlying diseases or history of taking any medications. He was a never-smoker, and social ... | |||||||||
PMC10038768 | Flagellate-like dermatitis in a child with autoinflammatory disorder managed with colchicine | JAAD Case Reports | 2023-04-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038768/ | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Flagellate dermatitis is a rare patterned-skin eruption characterized by linear erythematous streaks with hyperpigmentation.1 Bleomycin, a sulfur-containing antineoplastic antibiotic, is known to have this side effect.1 It has also been reported after the ingestion of raw or undercooked shiitake mushrooms. Recently, a ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Flagellate dermatitis is a rare patterned-skin eruption characterized by linear erythematous streaks with hyperpigmentation.1 Bleomycin, a sulfur-containing antineoplastic antibiotic, is known to have this side effect.1 It has also been... | Flagellate dermatitis is a rare patterned-skin eruption characterized by linear erythematous streaks with hyperpigmentation.1 Bleomycin, a sulfur-containing antineoplastic antibiotic, is known to have this side effect.1 It has also been reported after the ingestion of raw or undercooked shiitake mushrooms. Recently, a ... | At the age of 3 months, the patient presented with recurrent episodes of high-grade fever, diffuse urticarial skin eruption, and polyarthritis associated with anemia, leukocytosis, and high-inflammatory markers. She underwent extensive workup for infectious causes, hemophagocytic lymphohistiocytosis, and malignancy, al... | Flagellate dermatitis presents as erythematous papules, macules, or bullae, in an intermingled linear pattern distributed over the trunk, extremities, and face, and is rarely observed in the pediatric age group. It is highly characteristic of bleomycin treatment but has also been reported with other chemotherapeutic ag... | None disclosed. | |||||||
PMC10039168 | Successful laparoscopic cholecystectomy for gallbladder hemorrhage from a Dieulafoy lesion in a patient on hemodialysis: a case report | Surgical Case Reports | 2023-03-24 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039168/ | Background Patients on long-term dialysis are prone to hemorrhagic complications, particularly uremic bleeding, but gallbladder hemorrhage is rare, even in patients on dialysis. There have been occasional reports of a Dieulafoy lesion being a cause of gastrointestinal hemorrhage, but its occurrence within the gallbladd... | Gastrointestinal hemorrhage has been described in patients on hemodialysis in association with peptic ulcer (20–30%), gastritis (20%), and telangiectasia of the stomach, duodenum, jejunum, and colon (20–30%) . However, gallbladder hemorrhage is rarely encountered even in patients on dialysis with bleeding diathesis. Th... | [
{
"section_type": "background",
"heading": "Background",
"text": "Gastrointestinal hemorrhage has been described in patients on hemodialysis in association with peptic ulcer (20–30%), gastritis (20%), and telangiectasia of the stomach, duodenum, jejunum, and colon (20–30%) . However, gallbladder hemorrh... | Gastrointestinal hemorrhage has been described in patients on hemodialysis in association with peptic ulcer (20–30%), gastritis (20%), and telangiectasia of the stomach, duodenum, jejunum, and colon (20–30%) . However, gallbladder hemorrhage is rarely encountered even in patients on dialysis with bleeding diathesis. Th... | A 68-year-old woman presented with dizziness and diagnosed with end-stage renal failure caused by nephrosclerosis and aplastic anemia 23 years ago. She had been on hemodialysis and treated with anabolic steroids and prednisolone for 22 years. While on hemodialysis and treatment with heparin at our hospital, she develop... | Gallbladder hemorrhage is a rare entity and is most commonly associated with gallstones, acute cholecystitis, and use of antiplatelet or anticoagulants [6–8]. In this case, there was no obvious evidence of gallstones or neoplastic lesions, oral anticoagulant medication, or episodes of trauma. Although the patient had b... | We have encountered a case of gallbladder hemorrhage from a Dieulafoy lesion in a 68-year-old patient on hemodialysis who was treated successfully by laparoscopic cholecystectomy. In view of the potentially serious complications, a Dieulafoy lesion should be diagnosed and treated as early as possible. This lesion shoul... | |||||||
PMC10039493 | Small bowel segment with Meckel’s diverticulum volvulus related to short mesodiverticular band: a case report | Journal of Medical Case Reports | 2023-03-25 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039493/ | Background Meckel’s diverticulum is a remnant of the omphalomesenteric duct and occurs in only about 2% of people. Mesodiverticular band is the congenital remnant of the vitelline artery and is an even less often occurring phenomenon. Presented case We present the case of a 56-year-old Caucasian male who was admitted t... | There are many potential etiologies of small bowel obstruction (SBO). The most common cause of SBO are post-surgical adhesions . However, it may also occur in patients without any previous surgical interventions or other known pathology, in patients with a so-called virgin abdomen (VA). Reported etiologies of SBO-VA in... | [
{
"section_type": "background",
"heading": "Background",
"text": "There are many potential etiologies of small bowel obstruction (SBO). The most common cause of SBO are post-surgical adhesions . However, it may also occur in patients without any previous surgical interventions or other known pathology, ... | There are many potential etiologies of small bowel obstruction (SBO). The most common cause of SBO are post-surgical adhesions . However, it may also occur in patients without any previous surgical interventions or other known pathology, in patients with a so-called virgin abdomen (VA). Reported etiologies of SBO-VA in... | A 56-year-old Caucasian male was admitted to the emergency department (ED) with severe abdominal pain for 4 hours, which started suddenly. His significant past medical history included only the surgery of his left shoulder. He reported no abdominal surgeries, chronic diseases or permanent medications. We asked him a fe... | MD is the remnant of omphalomesenteric duct and it is the most common congenital malformation of GI tract. MD is present in approximately 2% of people. The majority of MD are asymptomatic. Complications are described only in 4–6% of cases, which most commonly include hemorrhage, intestinal obstruction, diverticulitis, ... | SBO is a common reason for admission to the surgical department. In the differential diagnosis of the causes of SBO, we should remember rare causes such as MDB. Without CT imaging, the patient would have been treated conservatively, which in the case of complicated MD could have led to fatal complications, including de... | |||||||
PMC10039813 | Presumed veterinary niclosamide-induced retinal toxicity in a human: a case report | Journal of Medical Case Reports | 2023-03-26 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039813/ | Background To report the first case of bull’s eye maculopathy associated with veterinary niclosamide. Case presentation A 27-year-old Iranian female presented with a history of reduced vision and photopsia since 3 years, after accidental ingestion of four boluses of veterinary niclosamide. Fundus examination showed atr... | Niclosamide has been commonly prescribed for the treatment of intestinal parasite infections for several decades. This drug kills tapeworms by inhibiting oxidative phosphorylation in the mitochondria and anaerobic adenosine triphosphate (ATP) production . Recent studies have shown its potential in treating many other d... | [
{
"section_type": "background",
"heading": "Background",
"text": "Niclosamide has been commonly prescribed for the treatment of intestinal parasite infections for several decades. This drug kills tapeworms by inhibiting oxidative phosphorylation in the mitochondria and anaerobic adenosine triphosphate (... | Niclosamide has been commonly prescribed for the treatment of intestinal parasite infections for several decades. This drug kills tapeworms by inhibiting oxidative phosphorylation in the mitochondria and anaerobic adenosine triphosphate (ATP) production . Recent studies have shown its potential in treating many other d... | A 28-year-old Iranian female was referred to Farabi Eye Hospital complaining of vision loss and photopsia in both eyes for 3 years. Her father was a ranchman, and she accidentally took four boluses of veterinary niclosamide (1250 mg in each bolus) 3 years ago. She announced that the visual problems had begun just a few... | This case describes a long-standing retinopathy in a 28-year-old woman as a result of veterinary niclosamide toxicity. Although there are several reports of persistent retinopathy due to toxicity from other drugs in the literature, this is the first report of bull’s-eye retinopathy due to niclosamide toxicity.
Niclosa... | Veterinary niclosamide is an anthelmintic drug that, in higher doses, could be detrimental to the human retina. It seems that veterinary niclosamide has a long-term detrimental impact on the mentioned structures, with no discernible recovery after 3 years. Appropriate drug labeling along with awareness about its side e... | |||||||
PMC10040453 | Malignant phyllodes tumor of the breast with heterologous osteosarcoma and chondrosarcomatous differentiation: A rare case report with imaging findings | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040453/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Phyllodes tumors of the breast are rare fibroepithelial neoplasms accounting for 0.3%-1.5% of all female breast tumors . Malignant transformations occur in 10%-20% of phyllodes tumors, often in the form of stroma. Heterologous osteosarcoma and chondrosarcomatous differentiation of phyllodes tumor are extremely rare, an... | Phyllodes tumor of the breast is a rare biphasic neoplasm with epithelial and stromal components, and accounts for 2.5% of all fibroepithelial neoplasms [, , , ]. They occur predominantly in women with a median age of 42-45 years , and are generally characterized by a rapidly growing large palpable mass. They are class... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Phyllodes tumor of the breast is a rare biphasic neoplasm with epithelial and stromal components, and accounts for 2.5% of all fibroepithelial neoplasms [, , , ]. They occur predominantly in women with a median age of 42-45 years , and ... | Phyllodes tumor of the breast is a rare biphasic neoplasm with epithelial and stromal components, and accounts for 2.5% of all fibroepithelial neoplasms [, , , ]. They occur predominantly in women with a median age of 42-45 years , and are generally characterized by a rapidly growing large palpable mass. They are class... | A 52-year-old woman presented with a right breast mass that had rapidly increased in size over a period of 2 months. She had no family history of breast cancer, and did not take oral contraceptives or hormone replacement medications. Breast ultrasonography (US)-guided core needle biopsy of her right breast mass was per... | Phyllodes tumors are fibroepithelial neoplasms with characteristic architectural features composed of an epithelial component and a cellular stromal component . The World Health Organization has subcategorized phyllodes tumors into benign, borderline, and malignant categories on the basis of 5 histological parameters: ... | We present a rare case of malignant phyllodes tumor with heterologous osteosarcoma and chondrosarcomatous differentiation in a 52-year-old woman. Since there is a paucity of scientific evidence regarding the management of such tumors, multicenter studies and long-term follow up are necessary to develop management guide... | Written consent was obtained for the publication of the current case. No patient identifiers disclosed. | |||||
PMC10040689 | Neuroendocrine carcinoma of cervix and review literature | International Journal of Surgery Case Reports | 2023-04-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040689/ | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Introduction Neuroendocrine carcinoma of the cervix (NECC) is a rare variant of cervical cancer with poor prognosis and high mortality. Recurrence is seen with multi-organ metastasis including liver. Case presentation A 65 year old female presented with vaginal bleeding for the past one year. Cervical cancer screening ... | 1
Neuroendocrine neoplasms (NENs) are described as malignant growth arising from neuroendocrine cells with a common occurrence in the gastrointestinal tract, pancreas, and lung . These cells belong to the embryonic neuroectodermal origin and demonstrate an immunohistochemical profile similar to that of endocrine cells... | [
{
"section_type": "background",
"heading": "Background",
"text": "1\n\nNeuroendocrine neoplasms (NENs) are described as malignant growth arising from neuroendocrine cells with a common occurrence in the gastrointestinal tract, pancreas, and lung . These cells belong to the embryonic neuroectodermal orig... | 1
Neuroendocrine neoplasms (NENs) are described as malignant growth arising from neuroendocrine cells with a common occurrence in the gastrointestinal tract, pancreas, and lung . These cells belong to the embryonic neuroectodermal origin and demonstrate an immunohistochemical profile similar to that of endocrine cells... | 2
A postmenopausal woman in her 60's presented with two episodes of vaginal bleeding for the past years. Cervical screening demonstrated changes consistent with high-grade (poorly differentiated) dyskaryosis/invasive squamous carcinoma. On biopsy, histomorphology showed features suggestive of poorly differentiated inv... | 3
Neuroendocrine tumors (NET) originate from the embryonic neuroectoderm. Their immunohistochemical profile is similar to cells of endocrine gland . Peptide hormones may not be secreted from these tumors. Common sites of involvement are the gastrointestinal tract, pancreas, and lungs and are subdivided in well-differe... | 4
Due to the aggressive nature of cervical neuroendocrine tumor patients must be kept under careful observation with regular follow up. Cells characteristic of neuroendocrine tumor of cervix are present only in a few nests, and could initially be missed. Metastasis in such cases particularly to the liver, lungs, and r... | This is certified that the Patient's consent has been taken for this manuscript. Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consentis available for review by the Editor-in-Chief of this journal on request.
Ethical clearance ... | |||||
PMC10041236 | Can COVID-19 lead to Addison’s disease in individual living with HIV? A case report and literature review | Journal of Family Medicine and Primary Care | 2022-11-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041236/ | This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identi... | A BSTRACT We report a case of a 46-year-old female with HIV for the last 15 years admitted to our hospital with a history of fever. She was diagnosed with pneumonia and was treated with antibiotics and recovered well; however, she was found to be hyponatremic. She mentioned that she tested positive for coronavirus dise... | Adrenal insufficency occurs because of failure of the adrenal gland to produce adequate steroids, especially cortisol. Undiagnosed Addison’s disease is associated with high mortality and morbidity; therefore, early diagnosis and treatment are crucial to save lives. Importantly, in Western countries, 90% of patients wit... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Adrenal insufficency occurs because of failure of the adrenal gland to produce adequate steroids, especially cortisol. Undiagnosed Addison’s disease is associated with high mortality and morbidity; therefore, early diagnosis and treatme... | Adrenal insufficency occurs because of failure of the adrenal gland to produce adequate steroids, especially cortisol. Undiagnosed Addison’s disease is associated with high mortality and morbidity; therefore, early diagnosis and treatment are crucial to save lives. Importantly, in Western countries, 90% of patients wit... | We report a case of a 46-year-old woman who was admitted to our hospital with cough, fever, and vomiting. She is otherwise well with no chest pain, shortness of breath, urine symptoms, or visual disturbances, with a normal bowel habit. One week prior to the admission, she was treated with antibiotics in the community f... | This case demonstrates that patients with prior COVID-19 infection are at a higher risk of developing adrenal insufficiency, especially in association with HIV. Different case reports and studies showed an association between COVID-19 and adrenal insufficiency. An example is the case report of a 64-year-old female who ... | Further research is needed to establish the association between HIV and adrenal insufficiency following COVID-19 infections | The authors certify that they have obtained appropriate patient consent form. In the form, the patient has given her consent for her clinical information to be reported in the journal. The patient understand that her name and initials will not be published, and due efforts will be made to conceal her identity.
The cas... | |||||
PMC10041613 | Limb myorhythmia treated with chemodenervation: a case report | Therapeutic Advances in Neurological Disorders | 2023-03-24 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041613/ | This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( | We describe a case of limb myorhythmia successfully palliated with botulinum toxin injections. The patient is a 30-year-old male evaluated for abnormal movements of the left lower foot that began after an ankle injury for which the patient underwent Achilles tendon scar tissue debridement without improvement. On examin... | We describe a case of limb myorhythmia treated with botulinum toxin injection. The patient is a 30-year-old male first seen in neurology clinic on 1 April 2019 for abnormal movements of his left leg which started in 2016. He described them as visible movement of the toes of his left foot with associated pulsation and t... | [
{
"section_type": "case_presentation",
"heading": "Case report",
"text": "We describe a case of limb myorhythmia treated with botulinum toxin injection. The patient is a 30-year-old male first seen in neurology clinic on 1 April 2019 for abnormal movements of his left leg which started in 2016. He descr... | We describe a case of limb myorhythmia treated with botulinum toxin injection. The patient is a 30-year-old male first seen in neurology clinic on 1 April 2019 for abnormal movements of his left leg which started in 2016. He described them as visible movement of the toes of his left foot with associated pulsation and t... | Myorhythmia is defined as a repetitive, rhythmic, slow frequency (1–4 Hz) movement1 affecting mainly the cranial and limb muscles. The tremor typically occurs at rest but can occasionally be present with movement and voluntary activity, usually disappearing with sleep. It is caused by an alternating or synchronous cont... | sj-png-1-tan-10.1177_17562864221150317 – Supplemental material for Limb myorhythmia treated with chemodenervation: a case reportClick here for additional data file.Supplemental material, sj-png-1-tan-10.1177_17562864221150317 for Limb myorhythmia treated with chemodenervation: a case report by Nil Saez-Calveras, Meredi... | |||||||
PMC10041733 | An unusual presentation of a rare disease: acute upper limb ischemia as the presenting symptom of Whipple’s Endocarditis, a case report | BMC Infectious Diseases | 2023-03-27 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041733/ | Background Whipple's disease is known to cause multiple varied systemic symptoms, and is a well-documented cause of culture-negative endocarditis. Endocarditis secondary to Whipple disease, however, has rarely been known to present primarily as a cause of acute limb ischemia. We describe such a case here. Case presenta... | Whipple’s disease is a rare disease caused by Tropheryma whipplei, a gram-positive bacillus. The spectrum of clinical findings due to T. whipplei infection is wide [1, 2]. Classic Whipple’s disease involves multiple organ systems and causes a well-described syndrome of gastrointestinal symptoms, arthralgia, and weight ... | [
{
"section_type": "background",
"heading": "Background",
"text": "Whipple’s disease is a rare disease caused by Tropheryma whipplei, a gram-positive bacillus. The spectrum of clinical findings due to T. whipplei infection is wide [1, 2]. Classic Whipple’s disease involves multiple organ systems and caus... | Whipple’s disease is a rare disease caused by Tropheryma whipplei, a gram-positive bacillus. The spectrum of clinical findings due to T. whipplei infection is wide [1, 2]. Classic Whipple’s disease involves multiple organ systems and causes a well-described syndrome of gastrointestinal symptoms, arthralgia, and weight ... | A 40-year-old man with no significant past medical history except tobacco use presented to the emergency department (ED) at a local hospital with right arm paresthesia and worsening pain for two days. He reported lethargy over the preceding few months and night chills but no measured fevers. He recalled a transient epi... | Tropheryma whipplei, the causative organism in Whipple’s disease, is a Gram-positive bacillus classically causing chronic diarrhea leading to malnutrition. Clinically, the disease can present in many different ways, including polyarthralgias, endocarditis, and neuropsychiatric changes.
Whipple’s endocarditis is a rare... | ||||||||
PMC10041946 | Anaplastic large cell lymphoma ALK-positive variant of primary bone lymphoma associated with melanoma | Oxford Medical Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041946/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( | ABSTRACT We describe in detail a case of the anaplastic large cell lymphoma (ALCL) type of primary bone lymphoma, which initially was diagnosed and treated as osteomyelitis. The diagnosis was delayed because of unspecific clinical symptoms and uncertain radiographs and histology. Only relapse of the lymphoma from the s... | Primary bone lymphoma (PBL) is a rare type of extranodal lymphoma, representing 3% of all malignant bone tumors and 1% of all malignant lymphomas. The etiology of PBL is unknown; viral agents and immunosuppression are implicated in some cases. Cytogenetic and molecular abnormalities are involved in the pathophysiology ... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Primary bone lymphoma (PBL) is a rare type of extranodal lymphoma, representing 3% of all malignant bone tumors and 1% of all malignant lymphomas. The etiology of PBL is unknown; viral agents and immunosuppression are implicated in some... | Primary bone lymphoma (PBL) is a rare type of extranodal lymphoma, representing 3% of all malignant bone tumors and 1% of all malignant lymphomas. The etiology of PBL is unknown; viral agents and immunosuppression are implicated in some cases. Cytogenetic and molecular abnormalities are involved in the pathophysiology ... | A 35-year-old Caucasian man began to have spontaneous pain in the left hip in August 2017. He used nonsteroidal anti-inflammatory drugs, which relieved the pain. He was admitted to the hospital in September 2017 complaining of intense pain that worsened when he did weight-bearing activities. He also reported that pain ... | PBL is defined as (i) a single bone lesion, with or without the involvement of regional lymph nodes; or (ii) multiple bone lesions without lymph nodal or visceral disease. The differential diagnosis generally considers chronic osteomyelitis, primary bone sarcoma, Ewing sarcoma, rhabdomyosarcoma, small cell lung carcino... | |||||||
PMC10043599 | Acute disseminated encephalomyelitis (ADEM)-like illness in a pediatric patient following COVID-19 vaccination | BJR | Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043599/ | This is an open access article distributed under the terms of the | Since the inception of the COVID-19 pandemic, over 60 cases of acute disseminated encephalomyelitis (ADEM) or ADEM-like clinically isolated syndromes have been linked to COVID-19 infection. However, cases linked to COVID-19 vaccination remain exceptionally rare. To the author’s knowledge, eight published cases of ADEM ... | ADEM is a rare autoimmune demyelinating central nervous system disease, typically associated with pediatric patients younger than 15 years of age.
1–3
However, it can occur at any age. It is classically preceded by recent viral illness or vaccination,
1–3
with some reports indicating that less than 5% of cases occur ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "ADEM is a rare autoimmune demyelinating central nervous system disease, typically associated with pediatric patients younger than 15 years of age.\n1–3\n However, it can occur at any age. It is classically preceded by recent viral illne... | ADEM is a rare autoimmune demyelinating central nervous system disease, typically associated with pediatric patients younger than 15 years of age.
1–3
However, it can occur at any age. It is classically preceded by recent viral illness or vaccination,
1–3
with some reports indicating that less than 5% of cases occur ... | A 10-year-old female with no past medical history presented to Golisano Childrens Hospital, Fort Myers, Florida, United States on December 21, 2021 with 7 days of progressive lower extremity weakness, paresthesia, and urinary retention. No recent symptoms of infection were reported. Neurological examination showed mild... | ADEM is a rapidly progressive autoimmune condition that causes multiple demyelinating inflammatory lesions in the brain and spinal cord.
1–5
The diagnosis should be suspected in a child who develops acute polyneuropathy in the setting of recent infection or immunization.
2
In our case, these clinical findings improve... | Little literature exists suggesting a relationship between COVID-19 vaccinations and acute demyelinating diseases in the pediatric population.Literature suggesting a relationship between COVID-19 vaccinations and acute demyelinating diseases has only pertained to adult patients.This is the first biopsy proven case that... | ||||||
PMC10043601 | Renal and mediastinal perivascular epithelioid cell tumors (PEComas) in a young child with tuberous sclerosis; a rare case report | BJR | Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043601/ | This is an open access article distributed under the terms of the | We describe a unique case of perivascular epithelioid cell tumors occurring as mediastinal and left renal soft tissue masses discovered incidentally in a 5-year-old tuberous sclerosis patient upon presentation to the emergency department for upper respiratory illness. The radiographic features were non-specific. Howeve... | A 5-year-old boy, a known case of tuberous sclerosis, presented to our emergency department (ED) complaining of a runny nose, cough, and fever for 1 week. Initial physical examination revealed congested tonsils and decreased air entry in the right lung. No chest compressive symptoms or remarkable abdominal complaints.
... | [
{
"section_type": "case_presentation",
"heading": "Case presentation",
"text": "A 5-year-old boy, a known case of tuberous sclerosis, presented to our emergency department (ED) complaining of a runny nose, cough, and fever for 1 week. Initial physical examination revealed congested tonsils and decreased... | A 5-year-old boy, a known case of tuberous sclerosis, presented to our emergency department (ED) complaining of a runny nose, cough, and fever for 1 week. Initial physical examination revealed congested tonsils and decreased air entry in the right lung. No chest compressive symptoms or remarkable abdominal complaints. | Chest X-ray showed a large mass in the right lower chest with broad base mediastinal attachment and multiple small nodular and tubular infiltrate in the right lower lobe. Ultrasound of the abdomen and pelvis revealed a sizeable exophytic mass arising from the lower pole of the left kidney measuring approximately 6 × 7 ... | For the left renal mass, renal cell carcinoma should be included in the differential diagnosis due to increase risk in TSC patients’, although, it’s rare to occur at that age. Lymphoma is also important differential diagnosis combining both lesions.
Perivascular epithelioid cell tumors (PEComas) are defined as “mesenc... | The diagnosis of benign perivascular epithelioid cell tumors was established based on extensive immunohistopathology analysis.
The multidisciplinary team (MDT) discussed the case thoroughly, and the group agreed on conservative management because the lesions were incidentally discovered despite the large size, histopa... | ||||||
PMC10043604 | Unusual case of a gigantic bladder mimicking a large pelvic cystic mass | BJR | Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043604/ | This is an open access article distributed under the terms of the | Pelvic masses are more common in females compared to the males. Bladder distension secondary to urinary retention can also mimic as a pelvic mass. However, it is rare to see chronic urinary retention with no clinical urinary symptoms. We present a case report of an elderly male who presented with abdominal pain and pro... | Generally, pelvic masses are a lot more common in the female population as compared to the males. However, most common pelvic masses in males are usually cancers of the bowel, bladder, and prostate. Distended bladder secondary to urinary retention may also mimic a pelvic mass. This is the first case recorded locally wh... | [
{
"section_type": "abstract",
"heading": "Summary",
"text": "Generally, pelvic masses are a lot more common in the female population as compared to the males. However, most common pelvic masses in males are usually cancers of the bowel, bladder, and prostate. Distended bladder secondary to urinary reten... | Generally, pelvic masses are a lot more common in the female population as compared to the males. However, most common pelvic masses in males are usually cancers of the bowel, bladder, and prostate. Distended bladder secondary to urinary retention may also mimic a pelvic mass. This is the first case recorded locally wh... | We present a case of a 79-year-old male, who presented to the hospital with abdominal distension and pain, progressive worsening of shortness of breathing and inability to sleep for the past few weeks. Surprisingly, no urinary symptoms were reported by the patient. On examination, a large right hypochondrial mass exten... | Urinary retention is a common presentation in the elderly population, especially amongst males. In general, within the next five years, 10% of males in their 70 s and 30% in their eighties will have urinary retention. The most known causes are Benign Prostatic Hyperplasia(BPH), bladder outlet obstruction such as urethr... | To conclude, while investigating cystic pelvic masses, the differential diagnosis of an overly distended bladder should be kept in mind, even in the absence of clinically correlating features, to avoid unnecessary invasive interventional procedures and their resulting complications. Also, elderly patients with frequent... | The Urology team reviewed the patient in the outpatient clinic, and it was decided that patient will remain on long-term urinary catheter and was commenced on tamsulosin and finasteride. As part of his follow up plan, a trial without catheter was advised by the urologist to avoid any surgical intervention. Despite of m... | |||||
PMC10046340 | Neurosyphilis Presenting as Syndrome of Limbic Encephalitis Mimicking Herpes Simplex Virus Neuro-Infection Diagnosed Using CXCL13 Point-of-Care Assay—Case Report | Brain Sciences | 2023-03-16 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046340/ | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( | The syndrome of limbic encephalitis is a severe clinical condition with heterogenous aetiopathogenesis. A common pathogen causing the infectious syndrome of limbic encephalitis is herpes simplex virus (HSV), but rare cases caused by Treponema pallidum have also been reported. We present the case of a 46-year-old man wh... | Syphilis is one of the most important sexually transmitted diseases, which despite effective and accessible antimicrobial treatment, still represents a global public health problem . The incidence of syphilis in high-income countries decreased in the 1980s and 1990s due to changes in sexual behaviour associated with th... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Syphilis is one of the most important sexually transmitted diseases, which despite effective and accessible antimicrobial treatment, still represents a global public health problem . The incidence of syphilis in high-income countries... | Syphilis is one of the most important sexually transmitted diseases, which despite effective and accessible antimicrobial treatment, still represents a global public health problem . The incidence of syphilis in high-income countries decreased in the 1980s and 1990s due to changes in sexual behaviour associated with th... | A 46-year-old, previously healthy Caucasian male (ethnic group—Slovak, West Slavic region), presented to the Emergency department of the Department of Infectology and Geographical Medicine, University Hospital in Bratislava, with a history of sudden onset of headaches, nausea, vomiting, and collapsed, with subsequent d... | Neurosyphilis, especially at the late stages, might mimic various neurological syndromes and diseases and present a great diagnostic challenge. The symptoms are often non-specific and diverse. The recent review of 50 cases describes a wide variety of symptoms, which most common were seizures, limb weakness, headaches, ... | Neurosyphilis and its variable clinical image often mimic other diagnoses such as meningoencephalitis, epilepsy, ischemia, a haemorrhage, or intoxication. Treponema pallidum encephalitis located in the temporal lobes involving the limbic system often imitates clinical and radiologic traits of encephalitis caused by HSV... | ||||||
PMC10047052 | An Unusual Case of Hemophagocytic Lymphohistiocytosis Associated with Mycobacterium chimaera or Large-Cell Neuroendocrine Carcinoma | Current Oncology | 2023-03-21 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047052/ | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( | Hemophagocytic lymphohistiocytosis (HLH) is a rare and very dangerous condition characterized by abnormal activation of the immune system, causing hemophagocytosis, inflammation, and potentially widespread organ damage. The primary (genetic) form, caused by mutations affecting lymphocyte cytotoxicity, is most commonly ... | Hemophagocytic lymphohistiocytosis (HLH) is a very rare disease process not commonly encountered in routine clinical practice, and its presentation is even more unusual in adult patients. HLH in an adult patient is usually indicative of some insidious underlying process.
This case required both extensive workup to mak... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Hemophagocytic lymphohistiocytosis (HLH) is a very rare disease process not commonly encountered in routine clinical practice, and its presentation is even more unusual in adult patients. HLH in an adult patient is usually indicative... | Hemophagocytic lymphohistiocytosis (HLH) is a very rare disease process not commonly encountered in routine clinical practice, and its presentation is even more unusual in adult patients. HLH in an adult patient is usually indicative of some insidious underlying process.
This case required both extensive workup to mak... | The patient was a 56-year-old Caucasian male who presented to the hospital with worsening weakness, exertional dyspnea, dry, nonproductive cough, loss of appetite, and a 5-pound weight loss in the 2 weeks prior. He had a significant medical history, including mitral valve repair in July 2014, status post bioprosthetic ... | The results of pertinent investigations included elevated triglycerides of 383, extremely high ferritin of 9335, haptoglobin of less than 8, high lactate dehydrogenase (LDH) of 1179, and low hemoglobin of 9.4, with a hematocrit of 27.4 and low platelets of 42. He had an acute kidney injury, with uptrending creatinine f... | Etoposide plus dexamethasone is the standard therapy for hemophagocytic syndrome.
The treatment plan for the patient was as follows:
Weeks 1 and 2: 10 mg/m2 daily.
Weeks 3 and 4: 5 mg/m2 daily.
Weeks 5 and 6: 2.5 mg/m2 daily.
Week 7: 1.25 mg/m2 daily.
Week 8: tapered to 0.
This is the schedule we followed. The t... | The differential diagnoses were very broad, including infection, such as visceral leishmaniasis, atypical/tuberculous mycobacteria, histoplasmosis, Ehrlichia, Bartonella, Brucella, Adenovirus, disseminated herpes simplex virus (HSV), hematological-like Langerhans cell histiocytosis, or multicentric Castleman disease; d... | The patient’s LFTs improved, his shortness of breath significantly improved, and he continued to show remarkable improvement day by day. He was discharged in stable condition.
He had a positron emission tomography (PET) scan done as an outpatient because of the lung nodule, and it showed a fluorodeoxyglucose (FDG) avi... | ||||
PMC10047054 | The Curious Case of the Choledochal Cyst—Revisiting the Todani Classification: Case Report and Review of the Literature | Diagnostics | 2023-03-10 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047054/ | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( | Choledochal cysts (CCs) are rare occurrences presenting as dilatations of biliary structures, which can present as single or multiple dilatations and can appear as both intra- and extrahepatic anomalies. The most widespread classification of CCs is the Todani classification, but there have been numerous reports of cyst... | Choledochal cysts (CCs) are uncommon congenital dilatations of the biliary tree, affecting its extrahepatic or intrahepatic segments or both at single and multiple sites. Most of them interest the common bile duct. CCs represent the second most frequent inborn biliary duct anomaly after biliary atresia .
The incidence... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Choledochal cysts (CCs) are uncommon congenital dilatations of the biliary tree, affecting its extrahepatic or intrahepatic segments or both at single and multiple sites. Most of them interest the common bile duct. CCs represent the ... | Choledochal cysts (CCs) are uncommon congenital dilatations of the biliary tree, affecting its extrahepatic or intrahepatic segments or both at single and multiple sites. Most of them interest the common bile duct. CCs represent the second most frequent inborn biliary duct anomaly after biliary atresia .
The incidence... | A 35-year-old male patient was referred to our clinic for a 5-day history of jaundice, fever, and abdominal pain. The physical examination revealed scleral icterus and right upper quadrant tenderness without inspiratory arrest at palpation (absent Murphy’s sign).
On admission, laboratory workup showed elevated serum l... | The medical literature is abundant in case reports of atypical, uncategorized bile duct cysts, and many experts recommend the revision of CCs classification.
A “forme fruste” of CC was described by Lilly et al. in 1985 and later reported by other authors as well, all of whom support its inclusion in the classification... | CCs are rare, premalignant anomalies of the biliary tract that present non-specific signs and symptoms. The diagnosis requires a high index of suspicion and thorough imaging studies. Early diagnosis and treatment are crucial for the avoidance of complications, the most severe of which is a malignant transformation that... | ||||||
PMC10047671 | Renal Cell Carcinoma Unclassified with Medullary Phenotype in a Patient with Neurofibromatosis Type 2 | Current Oncology | 2023-03-14 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047671/ | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( | We present, to our knowledge, the first reported case of germline neurofibromatosis Type 2 (NF2) associated with renal cell carcinoma unclassified with medullary phenotype (RCCU-MP) with somatic loss by immunohistochemistry of the SMARCB1 tumor suppressor gene located centromeric to NF2 on chromosome 22q. Our patient i... | Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by increased risk of central nervous system (CNS) tumors, including schwannomas, meningiomas, ependymomas, astrocytomas and neurofibromas . Bilateral vestibular schwannomas are highly suggestive of NF2. Other disease manifestations include p... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by increased risk of central nervous system (CNS) tumors, including schwannomas, meningiomas, ependymomas, astrocytomas and neurofibromas . Bilateral vest... | Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by increased risk of central nervous system (CNS) tumors, including schwannomas, meningiomas, ependymomas, astrocytomas and neurofibromas . Bilateral vestibular schwannomas are highly suggestive of NF2. Other disease manifestations include p... | Our patient is a Hispanic female who first presented at age 2 with clumsiness and dysarthria. Her initial MRI brain/face revealed right vestibular schwannoma but no other NF2-related pathology. Genetic testing was sent from a serum blood sample to the University of Alabama and analyzed for next generation sequencing (N... | Our patient represents a very unique oncologic case. Renal tumors are not usually screened for in NF2 patients. Although rare case reports show RCC with somatic mutations of NF2 in adult populations , RCC is very unusual in this age group and typically not associated with germline NF2 disease. There have previously bee... | The biopsy of right kidney demonstrated mostly fibrinous material with small fragments of renal parenchyma with interstitial chronic inflammation and no definite tumor. The biopsy of a retroperitoneal lymph node showed high grade tumor composed of discohesive rhabdoid cells with highly atypical nuclei and eosinophilic ... | ||||||
PMC10049791 | Robotic-assisted distal pancreatectomy with splenectomy in a paediatric patient for solid pseudopapillary tumour | Journal of Surgical Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049791/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( | ABSTRACT Solid pseudopapillary tumour is a rare low-grade malignant potential carcinoma of the pancreas that typically occurs in females in their third decade. It most commonly occurs in the tail of the pancreas, although any site can be affected. Surgical resection is the standard treatment and offers an excellent pro... | Solid pseudopapillary tumour (SPT) of the pancreas is a rare carcinoma estimated to comprise less than 3% of exocrine pancreatic tumours, although, thanks to the increasing in the access to radiological imaging such as computed tomography (CT) or magnetic resonance imaging (MRI), its incidence has been estimated to be ... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Solid pseudopapillary tumour (SPT) of the pancreas is a rare carcinoma estimated to comprise less than 3% of exocrine pancreatic tumours, although, thanks to the increasing in the access to radiological imaging such as computed tomograp... | Solid pseudopapillary tumour (SPT) of the pancreas is a rare carcinoma estimated to comprise less than 3% of exocrine pancreatic tumours, although, thanks to the increasing in the access to radiological imaging such as computed tomography (CT) or magnetic resonance imaging (MRI), its incidence has been estimated to be ... | In March 2022, a 17-year-old female with no past medical history was admitted to the Emergency Department with a 5-day history of recurring central quadrant pain and several episodes of emesis. At physical examination, she revealed a non-distended abdomen with minimal tenderness in the central quadrant. Ultrasound show... | Malignant pancreatic tumours are very rare in the paediatric population . Pancreatoblastoma and SPT are the most common epithelial tumours in this cohort of patients, followed by ductal adenocarcinoma, acinar cell carcinoma and pancreatic endocrine neoplasms . The most frequent presenting features of pancreatic tumours... | The authors report a case of a 17-year-old female with an SPT in the tail of the pancreas that was successfully treated with spleen preserving robotic-assisted distal pancreatectomy. We found that the advantages provided by a robotic approach, including improved surgical dexterity and visualization, allow for its use, ... | Marcello Spampinato.
Not commissioned, externally peer-reviewed.
None declared.
No funding was used.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal on req... | |||||
PMC10049844 | “An Unusual Pattern of Metastasis” Metastatic Malignant Thymoma Presented with Breast Lump: A Case Report and Literature Review | Case Reports in Surgery | 2023-01-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049844/ | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | Metastatic lesions to the breast from extramammary malignant neoplasms are rare and reported account for 0.5–6.6% of all breast malignancies. Distant metastasis of thymoma is even rarer, especially to extrathoracic regions. We reported a woman with invasive malignant thymoma postneoadjuvant and resection of the thymoma... | Thymomas are neoplasms that arise from thymic epithelium. The World Health Organization classified thymomas based on the morphology of epithelial cells as well as the lymphocyte-to-epithelial cell ratio. They are broadly divided into 5 types (type A, AB, B1, B2, and B3) . The staging of thymoma can be classified by Mas... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Thymomas are neoplasms that arise from thymic epithelium. The World Health Organization classified thymomas based on the morphology of epithelial cells as well as the lymphocyte-to-epithelial cell ratio. They are broadly divided into... | Thymomas are neoplasms that arise from thymic epithelium. The World Health Organization classified thymomas based on the morphology of epithelial cells as well as the lymphocyte-to-epithelial cell ratio. They are broadly divided into 5 types (type A, AB, B1, B2, and B3) . The staging of thymoma can be classified by Mas... | A 61-year-old woman with a history of malignant thymoma was diagnosed in year 2013 with superior vena cava involvement (Masaoka–Koga staging III) . She underwent neoadjuvant chemotherapy (3 cycles of cisplatin and carboplatin) followed by oncological thymoma resection surgery. Intraoperatively, the thymoma was measurin... | Metastatic lesions to the breast from extramammary malignant neoplasms are rare and reportedly account for 0.5–6.6% of all breast malignancies [3, 4]. Thymoma is a tumour originating from the epithelial cells of the thymus, typically presenting in the 4th or 5th decade of life. Thymic carcinoma is rare with an incidenc... | |||||||
PMC10049852 | Pyogenic granuloma of the thumb mimicking squamous cell carcinoma of the nail subunit: case report and review of the literature | Journal of Surgical Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049852/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( | ABSTRACT Pyogenic granuloma (PG) is a benign vascular lesion that usually occurs in the skin or mucous membranes. Multiple theories have been implicated in its aetiology. It can mimic variable malignancies in which histopathological examination plays a vital role. We report a case of PG of the left thumb nail subunit i... | Pyogenic granuloma (PG) or lobular capillary haemangioma is a benign vascular lesion that usually occurs in the skin or mucous membrane presented a single nodule or papule of rapid growth, bleeds easily with only a minimum of trauma [1–5]. It affects both genders and all ages with more tendency towards males and childr... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Pyogenic granuloma (PG) or lobular capillary haemangioma is a benign vascular lesion that usually occurs in the skin or mucous membrane presented a single nodule or papule of rapid growth, bleeds easily with only a minimum of trauma [1–... | Pyogenic granuloma (PG) or lobular capillary haemangioma is a benign vascular lesion that usually occurs in the skin or mucous membrane presented a single nodule or papule of rapid growth, bleeds easily with only a minimum of trauma [1–5]. It affects both genders and all ages with more tendency towards males and childr... | A 40-year-old gentleman, otherwise healthy, right-handed, presented with left thumb painless swelling progress rapidly in size over a period of 2 weeks after trauma by a wooden splinter. Initially, he sought medical advice in another facility where he was prescribed topical antibiotic. Nonetheless, the swelling persis... | PG is a benign vascular lesion that usually occurs in the skin or mucous membranes [1–5]. Most theories suggest that PG is a proliferative response of capillaries to an angiogenic stimulus such as trauma, this theory is similar to our case as this patient suffer from trauma to his thumb [1, 4, 6]. Giblin et al. found t... | No conflict of interest.
None. | ||||||
PMC10050674 | A case of sclerochoroidal calcification masquerading as a retained intraocular foreign body | Radiology Case Reports | 2023-05-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050674/ | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | A 41-year-old, New Zealand European male, was seen in the acute eye clinic as an in-patient from the trauma ward with multiple comorbidities including an orbital fracture from injuries sustained in a road traffic accident. It is not uncommon in emergency settings for emergency physicians to review polytrauma patients p... | Globally it is estimated that 55 million eye injuries occur annually , of which New Zealand reports an annual eye injury incidence of 1007/1,000,000 population/year . Intraocular foreign bodies are a rare yet serious outcome of ocular injuries with a retrospective population study in Waikato New Zealand reporting a 2.3... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Globally it is estimated that 55 million eye injuries occur annually , of which New Zealand reports an annual eye injury incidence of 1007/1,000,000 population/year . Intraocular foreign bodies are a rare yet serious outcome of ocular i... | In summary, sclerochoroidal calcification is a rare and usually benign condition which may masquerade as a retained intraocular foreign body as in the case of this patient. As CT is usually the first imaging modality used in trauma cases, radiologists are among the first to assess scans and as such hyper dense lesions ... | Globally it is estimated that 55 million eye injuries occur annually , of which New Zealand reports an annual eye injury incidence of 1007/1,000,000 population/year . Intraocular foreign bodies are a rare yet serious outcome of ocular injuries with a retrospective population study in Waikato New Zealand reporting a 2.3... | A 41-year-old, New Zealand European male, was seen in the acute eye clinic as an in-patient from the trauma ward with multiple comorbidities sustained from a car vs bicycle collision. the patient ejected off their bicycle and sustained a multitude of injuries relating to multiorgan perforations, lacerations, and fractu... | A diagnosis of a right unilateral scleral choroidal calcification at the site of the superior oblique insertion was made with no globe injury related to the trauma. At maxillo-facial review, a decision was made not to repair the orbital fracture given the absence of diplopia and enophthalmos. The patient was discharged... | This case highlights 2 main points: Ocular injuries and to a lesser extent retained intraocular foreign bodies, are extremely common in tripod facial fractures, requiring acute ophthalmology collaboration. Secondly, increasing the recognition of sclerochoroidal calcification as a masquerading condition to retained intr... | Once the patient was stabilized, follow up examinations for the tripod fracture were arranged by the Maxillofacial department with Ophthalmology input requested to investigate the possibility of a retained IOFB, given the hyperattenuating lesion noted in the right eye on CT imaging 1).1(A) Axial CT showing a hyperdense... | ||||
PMC10052119 | Ogilvie Syndrome and Acute Kidney Injury: A Rare Complication of Cesarean Section and Preeclampsia | Journal of Clinical Medicine | 2023-03-14 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052119/ | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( | Ogilvie syndrome, or acute colonic pseudo-obstruction (ACPS) is a rare occurrence, usually following surgery. It consists of a massive dilatation of the cecum, whose diameter becomes greater than 10 cm; its severity is variable, but, if not promptly recognized, it may be life-threatening. Acute kidney injury (AKI) is r... | Due to the protean presentation of the different hypertensive disorders of pregnancy, and to their high prevalence (up to 10% of pregnancies, considering the whole spectrum, from pregnancy induced hypertension to preeclampsia to hemolysis low platelet elevated liver enzymes (HELLP) syndrome), the differential diagnosis... | [
{
"section_type": "background",
"heading": "1. Background",
"text": "Due to the protean presentation of the different hypertensive disorders of pregnancy, and to their high prevalence (up to 10% of pregnancies, considering the whole spectrum, from pregnancy induced hypertension to preeclampsia to hemoly... | Due to the protean presentation of the different hypertensive disorders of pregnancy, and to their high prevalence (up to 10% of pregnancies, considering the whole spectrum, from pregnancy induced hypertension to preeclampsia to hemolysis low platelet elevated liver enzymes (HELLP) syndrome), the differential diagnosis... | A 35-year-old woman of African origin (Guinea Conakry) was referred during her pregnancy to a tertiary care obstetrical center. Her medical history was significant for malaria infection, allergy to quinine, and no surgery other than appendectomy during her adolescence. She had no family members affected by kidney disea... | When a patient experiences a complication during her pregnancy, due to the protean manifestations associated with preeclampsia or HELLP syndrome, these conditions are usually the first considered in the differential diagnosis; however, this may delay the correct diagnosis, as our case exemplifies.
In the context of a ... | |||||||
PMC10052466 | Cutaneous candidiasis mimicking acute generalized exanthematous pustulosis: A case report | SAGE Open Medical Case Reports | 2023-03-28 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052466/ | This article is distributed under the terms of the Creative Commons Attribution 4.0 License ( | Disseminated cutaneous candidiasis is a rare manifestation of candidiasis that arises most commonly from Candida albicans . It is described as a widespread erythematous papulopustular skin infection that typically affects premature newborns or immunocompromised patients. While candidal infections usually respond well t... | Candidal fungi are considered a normal feature of human microbiota, with approximately 50% of individuals living with candida in their mucosal epithelium.1 They are most notably found along the gastrointestinal and genital tracts.1 While there are hundreds of species of Candida, a much smaller fraction act as endogenou... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Candidal fungi are considered a normal feature of human microbiota, with approximately 50% of individuals living with candida in their mucosal epithelium.1 They are most notably found along the gastrointestinal and genital tracts.1 Whil... | Candidal fungi are considered a normal feature of human microbiota, with approximately 50% of individuals living with candida in their mucosal epithelium.1 They are most notably found along the gastrointestinal and genital tracts.1 While there are hundreds of species of Candida, a much smaller fraction act as endogenou... | Disseminated cutaneous candidiasis typically presents with diffuse erythematous maculopapular and pustular lesions, which can be accompanied by pruritus or burning. Lesions often start in flexures and then become disseminated.3,4 It preferentially affects immunocompromised patients with complex multicomorbidity and pol... | A 67-year-old male with a history of chronic lymphocytic leukemia (CLL), heart failure, type 2 diabetes mellitus, end-stage renal disease on hemodialysis, atrial fibrillation, pulmonary hypertension, and significant peripheral vascular disease with bilateral above-knee amputations presented to the emergency department ... | |||||||
PMC10052476 | Recurrent cutaneous eosinophilic vasculitis characterized by annular purpuric lesions: A case report | SAGE Open Medical Case Reports | 2023-03-28 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052476/ | This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( | A 71-year-old woman presented with a persistent, intensely pruritic cutaneous eruption localized on the palmoplantar regions, lips and palate. The histological findings allowed to make the diagnosis of recurrent cutaneous eosinophilic vasculitis, a very rare cutaneous vasculitis characterized clinically by multiple ery... | Recurrent cutaneous eosinophilic vasculitis (RCEV) is a very rare cutaneous vasculitis characterized clinically by pruritic purpuric papules and plaques and angioedema without systemic involvement and histologically by a necrotizing vasculitis of the dermal small vessels with a dominant eosinophilic infiltration.1,2 He... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Recurrent cutaneous eosinophilic vasculitis (RCEV) is a very rare cutaneous vasculitis characterized clinically by pruritic purpuric papules and plaques and angioedema without systemic involvement and histologically by a necrotizing vas... | Recurrent cutaneous eosinophilic vasculitis (RCEV) is a very rare cutaneous vasculitis characterized clinically by pruritic purpuric papules and plaques and angioedema without systemic involvement and histologically by a necrotizing vasculitis of the dermal small vessels with a dominant eosinophilic infiltration.1,2 He... | A 71-year-old Caucasian female patient presented with a 1-month history of a persistent, intensely pruritic eruption initially localized on the palmoplantar regions, lips and palate, which had appeared the day immediately after an episode of left retinal vein occlusion. The patient reported neither fever nor constituti... | RCEV is a very rare entity characterized clinically by multiple erythematous or purpuric erythematous papules or plaques or angioedema with a relapsing course and in the absence of systemic involvement.2 Histology classically reveals a necrotizing vasculitis with predominant eosinophilic infiltration, without granuloma... | |||||||
PMC10052659 | Carcinosarcoma of common bile duct: A case report | World Journal of Gastrointestinal Oncology | 2023-03-15 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052659/ | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commerciall... | BACKGROUND Carcinosarcomas of the common bile duct (CBD) are an extremely rare finding in the clinical setting. Based on a review of 12 literatures, 3 cases had the imaging features of ossification. Carcinosarcomas are prone to distant metastasis, as they possess clinical features of both carcinoma and sarcoma, and gen... | Core Tip: Carcinosarcomas of the common bile duct are extremely rare. Polypoid growth and ossification in the tumor could be representative features in cases of the sarcomal components being differentiated from bone. If misdiagnosed as biliary calculi, the use of laser lithotripsy may lead to tumor diffusion. Our case ... | [
{
"section_type": "other",
"heading": "",
"text": "Core Tip: Carcinosarcomas of the common bile duct are extremely rare. Polypoid growth and ossification in the tumor could be representative features in cases of the sarcomal components being differentiated from bone. If misdiagnosed as biliary calculi, ... | Carcinosarcomas of the common bile duct (CBD) are an extremely rare finding in the clinical setting, as they are mixture of carcinoma and sarcoma. Polypoid growth and ossification in the tumor could be representative features of carcinosarcomas of the extrahepatic bile duct. For the case discussed herein, the patient’s... | The patient’s symptoms had started 3 mo prior. | The patient was referred for general surgery. After general anesthesia, in the supine position, intraoperative exploration revealed a tumor located in the middle and lower part of the CBD (approximately 2 cm × 1.5 cm in size) with a hard texture and relatively limited, so cholecystectomy, CBD resection, and choledochoj... | Carcinosarcomas are rare malignant tumors consisting of a mixture of carcinoma and sarcoma, first named by Virchow (1864). According to the 1990 World Health Organization (WHO) histologic classification of tumors, a carcinosarcoma is defined as a neoplastic organism containing both carcinoma and sarcoma components with... | Carcinosarcomas of the CBD may have imaging features of polypoid growth and ossification only when the sarcomal components are bone differentiation, while show soft tissue shadow when non bone differentiation. Confirmation of diagnosis depends greatly upon postoperative pathological examination and the adjuvant treatme... | Core Tip: Carcinosarcomas of the common bile duct are extremely rare. Polypoid growth and ossification in the tumor could be representative features in cases of the sarcomal components being differentiated from bone. If misdiagnosed as biliary calculi, the use of laser lithotripsy may lead to tumor diffusion. Our case ... | ||||
PMC10053061 | A Successful Bisphosphonates Monotherapy in Spinal Form of Paediatric Chronic Recurrent Multifocal Osteomyelitis (CRMO)—Case Report | Metabolites | 2023-02-25 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053061/ | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( | Chronic recurrent multifocal osteomyelitis (CRMO) is a non-infectious inflammatory disorder resulting from the multifocal bone and bone marrow lesions with periodic relapses and remissions and with an uncertain prognosis. Treatment options in CRMO are based on expert opinion and relatively small groups of patients. A n... | Bone pain is a common symptom in children, which may result from physiological outgrowth, but also be a consequence of pathological processes present in the organism. One of the potential causes may be chronic recurrent multifocal osteomyelitis (CRMO), an autoimmune inflammation resulting from an imbalanced immune resp... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Bone pain is a common symptom in children, which may result from physiological outgrowth, but also be a consequence of pathological processes present in the organism. One of the potential causes may be chronic recurrent multifocal os... | Bone pain is a common symptom in children, which may result from physiological outgrowth, but also be a consequence of pathological processes present in the organism. One of the potential causes may be chronic recurrent multifocal osteomyelitis (CRMO), an autoimmune inflammation resulting from an imbalanced immune resp... | Treatment with pamidronate infusion was initiated in cycles over three consecutive days every 3 months. Before the administration of the pamidronate, the patient was treated with an oral sodium alendronate dose of 70 mg per week for 3 consecutive months. The daily dosage of pamidronate was calculated in relation to the... | Despite the growing body of evidence in the literature concerning the therapeutic strategies for CRMO, this rare disease remains a challenging issue without specific recommendations. Even among the relatively small population of patients affected by this disorder, there are some major differences in the clinical phenot... | A nine-years-old female patient with no significant past medical history presented with compression fractures and multifocal bone lesions in the thoracic and lumbar spine. The patient reported pain in the lumbar area which emerged after minor trauma. The pain increased in time and was triggered by movement lamination a... | ||||||
PMC10058500 | Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review | Life | 2023-02-21 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058500/ | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( | Duodenal gangliocytic paragangliomas are rare neuroendocrine tumors primarily localized in the periampullary area. Though mostly asymptomatic, they can present with various symptoms, most often jaundice, anemia and abdominal pain. The present paper is a case series report, describing our personal experience with patien... | Duodenal gangliocytic paragangliomas (GP) are rare neuroendocrine tumors, with less than 300 cases being reported worldwide, most of them as single case reports. Duodenal GPs arise mainly in the second part of the duodenum and in the periampullary region. Unlike other neuroendocrine neoplasia, GPs have a benign clinica... | [
{
"section_type": "background",
"heading": "1. Introduction",
"text": "Duodenal gangliocytic paragangliomas (GP) are rare neuroendocrine tumors, with less than 300 cases being reported worldwide, most of them as single case reports. Duodenal GPs arise mainly in the second part of the duodenum and in the... | Duodenal gangliocytic paragangliomas (GP) are rare neuroendocrine tumors, with less than 300 cases being reported worldwide, most of them as single case reports. Duodenal GPs arise mainly in the second part of the duodenum and in the periampullary region. Unlike other neuroendocrine neoplasia, GPs have a benign clinica... | We present the case of a 29-year-old male, without any significant medical history except for first grade obesity, who was sent to our hospital for recently debuted sclero-tegumentar jaundice, pruritus and epigastric pain, with a preliminary tomographic diagnosis of both vesicular lithiasis and choledocholithiasis esta... | Gangliocytic paragangliomas have a polymorphic clinical presentation. These tumors should be suspected in the presence of a polypoid duodenal lesion associated with obstructive jaundice which seems benign by sectional studies, upper digestive hemorrhage and anemia, or symptoms of carcinoid syndrome. EUS plays an import... | Pheochromocytomas (PCCs) and gangliocytic paragangliomas (GPs) are rare abnormal growths of chromaffin cells in the adrenal glands and elsewhere in the body, respectively. They can occur in almost any location, except for the bones and brain, all tumors having metastatic potential, with 20% of all tumors presenting in ... | ||||||
PMC10060757 | A case report of an unusual temporomandibular joint mass: Nodular fasciitis | Imaging Science in Dentistry | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060757/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( | Nodular fasciitis (NF) is a benign myofibroblastic proliferation that grows very rapidly, mimicking a sarcoma on imaging. It is treated by local excision, and recurrence has been reported in only a few cases, even when excised incompletely. The most prevalent diagnoses of temporomandibular joint (TMJ) masses include sy... | Nodular fasciitis (NF) is a benign myofibroblastic proliferation typically occurring in the subcutaneous tissue, fascia, and muscle.1 It was first reported by Konwaler et al.2 as a subcutaneous pseudosarcomatous fibromatosis. NF presents as a rapidly enlarging mass and patients often complain of soreness and tenderness... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Nodular fasciitis (NF) is a benign myofibroblastic proliferation typically occurring in the subcutaneous tissue, fascia, and muscle.1 It was first reported by Konwaler et al.2 as a subcutaneous pseudosarcomatous fibromatosis. NF present... | Nodular fasciitis (NF) is a benign myofibroblastic proliferation typically occurring in the subcutaneous tissue, fascia, and muscle.1 It was first reported by Konwaler et al.2 as a subcutaneous pseudosarcomatous fibromatosis. NF presents as a rapidly enlarging mass and patients often complain of soreness and tenderness... | A 54-year-old woman presented to the Department of Oral Medicine at Seoul National University Dental Hospital with a 4-month history of pain during mouth opening in the left posterior auricular area extending to the inferior border of the mandible. She also complained of random episodes of slight hearing loss, but repo... | In this case, the mass was located in the retrodiscal area, extending down into the parotid parenchyma. Due to the extent of the lesion, a parotid primary mass extending superiorly into the retrodiscal area needed to be ruled out. A close assessment of the sagittal and coronal view of CECT and MRI indicated that the ma... | |||||||
PMC10062311 | Guillain‐Barre syndrome secondary to COVID‐19 infection: A case report | Clinical Case Reports | 2023-03-30 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062311/ | This is an open access article under the terms of the | Abstract Guillain‐Barre syndrome (GBS) is a rare autoimmune disease that often manifests as a post‐viral complication. However, its association with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is unclear. We present a rare case of GBS secondary to COVID‐19 infection complicated by rapidly progressive s... | 1
Starting at the end of 2019 in Wuhan, China, the coronavirus disease 2019 (COVID‐19) has been responsible for millions of infections worldwide. Patients commonly present with cough, myalgia, fatigue, and diarrhea.
1
In a retrospective observational case series of 214 cases of COVID‐19 in Wuhan, China, 78 patients w... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "1\n\nStarting at the end of 2019 in Wuhan, China, the coronavirus disease 2019 (COVID‐19) has been responsible for millions of infections worldwide. Patients commonly present with cough, myalgia, fatigue, and diarrhea.\n1\n In a retrosp... | 1
Starting at the end of 2019 in Wuhan, China, the coronavirus disease 2019 (COVID‐19) has been responsible for millions of infections worldwide. Patients commonly present with cough, myalgia, fatigue, and diarrhea.
1
In a retrospective observational case series of 214 cases of COVID‐19 in Wuhan, China, 78 patients w... | 2
A previously healthy 60‐year‐old man with pectus excavatum was brought in by ambulance for a 2‐day history of rapidly progressive bilateral ascending weakness, bilateral paresthesia of the hands and feet, difficulty standing, and low back pain. Three days prior to presentation, he tested positive for COVID‐19 and re... | 3
The incidence of GBS is between 1.1/100,000/year and 1.8/100,000/year with lower rates reported in children (<16 years) of around 0.6/100,000/year according to a systematic literature review conducted in 2009.
10
More recently, a one‐year observational multicenter study in Northern Italy found that the cumulative i... | 4
Guillain‐Barre Syndrome (GBS) is oftentimes a post‐infectious immune‐mediated radiculopathy that commonly results in neuromuscular respiratory failure. We present a rare case of GBS secondary to COVID‐19 infection. Clinicians should consider COVID‐19 as a viral infection that can trigger immune‐mediated pathologies ... | Dena H. Tran: Conceptualization; data curation; formal analysis; resources; validation; writing – original draft; writing – review and editing. Dalwinder Basra: Writing – review and editing. Zaid Bilgrami: Writing – review and editing. Suryanarayana R. Challa: Investigation. Christina Kwon: Investigation. Ellen Marcini... | |||||
PMC10063196 | Thinking beyond otorhinolaryngology in patients presenting with bilateral vocal cord paresis | Journal of Surgical Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063196/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( | Abstract Anti-immunoglobulin-like cell adhesion molecule 5 (IGLON5), a disease first described in 2014 by Sabater et al ., is characterised by dysphonia, dysphagia, stridor and dysautonomia. We discuss the case of a patient presenting to the emergency department with anti-IGLON5 associated airway compromise following p... | Anti-immunoglobulin-like cell adhesion molecule 5 (IGLON5) is a novel disease first described by Sabater et al. and as such awareness of the condition and its complications may be limited, leading to delayed or incorrect diagnosis. In this report, we present the case of a patient diagnosed with anti-IGLON5 and discuss ... | [
{
"section_type": "background",
"heading": "INTRODUCTION",
"text": "Anti-immunoglobulin-like cell adhesion molecule 5 (IGLON5) is a novel disease first described by Sabater et al. and as such awareness of the condition and its complications may be limited, leading to delayed or incorrect diagnosis. In t... | Anti-immunoglobulin-like cell adhesion molecule 5 (IGLON5) is a novel disease first described by Sabater et al. and as such awareness of the condition and its complications may be limited, leading to delayed or incorrect diagnosis. In this report, we present the case of a patient diagnosed with anti-IGLON5 and discuss ... | A 74-year-old, Caucasian male, presented to ENT with a 5-month history of dysphonia, mild intermittent dysphagia. Past medical history included of hypertension, obstructive sleep apnoea (OSA) and degenerative arthritis. Examination revealed an asymmetrical laryngeal inlet with reduced right-sided vocal cord movement an... | Anti-IgLON5 disease, first described in 2014, is a neurodegenerative autoimmune disease, which can present over years with sleep disturbances, breathing changes and gait instability . Bulbar symptoms such as stridor, dysphagia and central hypoventilation have been described in 60% of patients . Another review discussed... | |||||||
PMC10063741 | Myxolipoma of hand in a child: case report of a rare tumor | Journal of Ultrasound | 2022-09-24 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063741/ | Lipomatous tumors account for less than 10% of tumors in the pediatric population. Myxolipomas (a subset of lipoma characterised by mature adipose tissue and abundant mucoid substance) are found to be even rarer. There are a few case reports in different body parts like heart, kidney, oral cavity, epiglottis, cervical ... | Lipomatous tumors account for less than 10% of tumors in the pediatric population. There are several variants of lipomas based on the type of mesenchymal components present and the histopathological findings.
Myxolipoma is one such uncommon variant characterised by mature adipose tissue and abundant mucoid substance.
... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Lipomatous tumors account for less than 10% of tumors in the pediatric population. There are several variants of lipomas based on the type of mesenchymal components present and the histopathological findings.\n\nMyxolipoma is one such u... | Lipomatous tumors account for less than 10% of tumors in the pediatric population. There are several variants of lipomas based on the type of mesenchymal components present and the histopathological findings.
Myxolipoma is one such uncommon variant characterised by mature adipose tissue and abundant mucoid substance.
... | A 22 month old male presented with a painless swelling in the left hand, that caused difficulty in grasping objects. The swelling was predominantly in the palmar aspect causing widening of the 2nd and 3rd web space 1). It was first noticed by the parents 4 months ago, and has since grown in size. It measured approximat... | X-ray and high resolution ultrasound were advised to determine nature and extent of lesion. Plain X-ray of the hand revealed a lobulated homogeneous, smoothly outlined, soft tissue mass which was seen to cause widening of the webspace between the 2nd and 3rd fingers. The underlying bones were normal with no evidence of... | The parents agreed to an excision biopsy and the entire tumor was removed surgically 6). Gross examination of the specimen revealed a yellowish and gray white soft tissue lesion of size 40 × 30 × 25 mm and showed a lobulated contour 7). Cut section showed soft to mucoid areas. Microscopic examination showed a well circ... | Adipocytic tumours are mesenchymal tumors with considerable morphologic and genetic heterogenicity . In children,adipose and myxoid tumors form a challenging group of neoplasms in contrast to adults . Lipomatous tumors,which is common in adults,account for less than 10% of all soft tissue lesions in pediatric patients ... | Myxolipoma, a variant of lipoma, is a rare benign adipose tumor that can now be considered as a differential diagnosis in lipomatous soft tissue tumors of the extremities in all age groups and in the pediatric hand. A biopsy is imperative for a final histo-pathological diagnosis. High resolution musculoskeletal ultraso... | |||||
PMC10064264 | Post-Bentall procedure ‘pseudo’ pulmonary embolism, cardiac tamponade in disguise: a case report | European Heart Journal: Case Reports | 2023-03-01 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064264/ | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( | Abstract Background Post-operative cardiac complications require rapid evaluation, which may be hindered by various challenges. Sudden shortness of breath with persisting haemodynamic failure after cardiac procedure is often associated with cases of pulmonary embolism or cardiac tamponade that have contradicting therap... | Post-operative cardiac complications require rapid assessment that may be hindered by various challenges. Sudden shortness of breath with persisting haemodynamic failure after cardiac procedure is often associated with cases of PE or cardiac tamponade.1 Anticoagulant therapy is the treatment of choice for PE; however, ... | [
{
"section_type": "background",
"heading": "Introduction",
"text": "Post-operative cardiac complications require rapid assessment that may be hindered by various challenges. Sudden shortness of breath with persisting haemodynamic failure after cardiac procedure is often associated with cases of PE or ca... | Post-operative cardiac complications require rapid assessment that may be hindered by various challenges. Sudden shortness of breath with persisting haemodynamic failure after cardiac procedure is often associated with cases of PE or cardiac tamponade.1 Anticoagulant therapy is the treatment of choice for PE; however, ... | A 45-year-old obese male with Stanford A DeBakey type-II aortic dissection, atrioventricular re-entrant tachycardia, and atrial regurgitation was complaining of chest discomfort accompanied by palpitations, nausea, and cold sweats. Patient had a history of controlled hypertension with nebivolol 2 × 5 mg, as well as per... | Imaging modalities have their advantages and limitations when it comes to post-operative cardiac complications evaluation. The obstruction of pulmonary blood flow may be found in both PE and cardiac tamponade depending on the location of blood accumulation. In our case, the site of leakage was predominantly at the righ... | This study highlights the importance of being critical towards utilization of various imaging modalities to confirm post-operative cardiac complications. Cardiac tamponade may mimic a case of PE, presenting with multiple imaging hallmark signs depending on the site of blood accumulation. Differentiating cardiac tampona... | ytad071_Supplementary_DataClick here for additional data file. |
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