id stringlengths 7 8 | document_id stringlengths 7 8 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
8524816 | 8524816 | [
{
"id": "8524816__text",
"type": "abstract",
"text": [
"Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets. \nActivation of individual CD4+ T cells results in differential lymphokine expression: interleukin 2 (IL-2) is ... | [
{
"id": "8524816_T1",
"type": "Protein",
"text": [
"CD4"
],
"offsets": [
[
157,
160
]
],
"normalized": []
},
{
"id": "8524816_T2",
"type": "Protein",
"text": [
"interleukin 2"
],
"offsets": [
[
217,
230... | [
{
"id": "8524816_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"produced"
],
"offsets": [
[
256,
264
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8524816_T3"
}
]
},
{
"id":... | [
{
"id": "8524816_1",
"entity_ids": [
"8524816_T2",
"8524816_T3"
]
}
] | [] |
9007200 | 9007200 | [
{
"id": "9007200__text",
"type": "abstract",
"text": [
"V3 loop of human immunodeficiency virus type 1 suppresses interleukin 2-induced T cell growth [published erratum appears in AIDS Res Hum Retroviruses 1997 May 1;13(7):633] \nWe tested the effect of three linear or two loop peptides derived fr... | [
{
"id": "9007200_T1",
"type": "Protein",
"text": [
"interleukin 2"
],
"offsets": [
[
58,
71
]
],
"normalized": []
},
{
"id": "9007200_T2",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
345,
349
... | [
{
"id": "9007200_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"blocked"
],
"offsets": [
[
1302,
1309
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9007200_E2"
}
]
},
{
... | [] | [] |
9277450 | 9277450 | [
{
"id": "9277450__text",
"type": "abstract",
"text": [
"Surfactant protein A activates NF-kappa B in the THP-1 monocytic cell line. \nThe expression of many genes for which products are involved in inflammation is controlled by the transcriptional regulator nuclear factor (NF)-kappa B. Because sur... | [
{
"id": "9277450_T1",
"type": "Protein",
"text": [
"Surfactant protein A"
],
"offsets": [
[
0,
20
]
],
"normalized": []
},
{
"id": "9277450_T2",
"type": "Protein",
"text": [
"tumor necrosis factor-alpha"
],
"offsets": [
... | [
{
"id": "9277450_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"blocked"
],
"offsets": [
[
995,
1002
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9277450_E2"
}
]
},
{
"... | [] | [] |
8314792 | 8314792 | [
{
"id": "8314792__text",
"type": "abstract",
"text": [
"Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes. \nNuclear factor of activated T cells (NFAT) is a transcriptional activator that binds to sequences in the interleukin-2 (IL-2) promoter ... | [
{
"id": "8314792_T1",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
211,
224
]
],
"normalized": []
},
{
"id": "8314792_T2",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
226,
23... | [
{
"id": "8314792_E1",
"type": "Binding",
"trigger": {
"text": [
"binds"
],
"offsets": [
[
185,
190
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8314792_T1"
},
{
"role": "Site",
... | [
{
"id": "8314792_1",
"entity_ids": [
"8314792_T1",
"8314792_T2"
]
},
{
"id": "8314792_2",
"entity_ids": [
"8314792_T4",
"8314792_T5"
]
}
] | [] |
8523529 | 8523529 | [
{
"id": "8523529__text",
"type": "abstract",
"text": [
"Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes. \nThe molecular mechanisms regulating human immunodeficiency virus (HIV) persistence in a major cell reservoir such as the macrophage rem... | [
{
"id": "8523529_T1",
"type": "Protein",
"text": [
"Protein kinase C-zeta"
],
"offsets": [
[
0,
21
]
],
"normalized": []
},
{
"id": "8523529_T2",
"type": "Protein",
"text": [
"PKC-zeta"
],
"offsets": [
[
759,
... | [
{
"id": "8523529_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"present"
],
"offsets": [
[
948,
955
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8523529_T3"
}
]
},
{
"id": ... | [] | [] |
8645254 | 8645254 | [
{
"id": "8645254__text",
"type": "abstract",
"text": [
"Abundant expression of erythroid transcription factor P45 NF-E2 mRNA in human peripheral granurocytes. \nTranscription factor NF-E2 is crucial for regulation of erythroid-specific gene expression. p45 subunit of NF-E2 contains a basic-leucine... | [
{
"id": "8645254_T1",
"type": "Protein",
"text": [
"erythroid transcription factor P45 NF-E2"
],
"offsets": [
[
23,
63
]
],
"normalized": []
},
{
"id": "8645254_T2",
"type": "Protein",
"text": [
"p45"
],
"offsets": [
[... | [
{
"id": "8645254_E1",
"type": "Transcription",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
9,
19
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8645254_T1"
}
]
},
{
"id": "8... | [] | [] |
7981603 | 7981603 | [
{
"id": "7981603__text",
"type": "abstract",
"text": [
"Glucocorticoid-induced apoptosis of lymphoid cells. \nThe induction of cell death in lymphoid cells by glucocorticoids is one of the earliest and most thoroughly studied models of apoptosis. Although the exact mechanism by which apoptosis occ... | [] | [] | [] | [] |
10331989 | 10331989 | [
{
"id": "10331989__text",
"type": "abstract",
"text": [
"Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. \nThe lineage-restricted transcription factor GATA-1 is required for differentiation of erythroid a... | [
{
"id": "10331989_T1",
"type": "Protein",
"text": [
"GATA-1"
],
"offsets": [
[
129,
135
]
],
"normalized": []
},
{
"id": "10331989_T2",
"type": "Protein",
"text": [
"GATA-1"
],
"offsets": [
[
187,
193
... | [
{
"id": "10331989_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"requirements"
],
"offsets": [
[
19,
31
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10331989_E2"
}
]
},
{
... | [
{
"id": "10331989_1",
"entity_ids": [
"10331989_T7",
"10331989_T8"
]
}
] | [] |
9195127 | 9195127 | [
{
"id": "9195127__text",
"type": "abstract",
"text": [
"Biphasic control of NF-kappa B activation induced by the triggering of HLA-DR antigens expressed on B cells. \nThe regulation of NF-kappa B activation following the triggering of HLA-DR antigens by mAb L243 has been studied at various times i... | [
{
"id": "9195127_T1",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
[
393,
402
]
],
"normalized": []
},
{
"id": "9195127_T2",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
[
566,
5... | [
{
"id": "9195127_E1",
"type": "Localization",
"trigger": {
"text": [
"secreted"
],
"offsets": [
[
576,
584
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9195127_T2"
}
]
},
{
"id": "9... | [] | [] |
9047239 | 9047239 | [
{
"id": "9047239__text",
"type": "abstract",
"text": [
"A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site. \nInterleukin-3 (IL-3) is a cytokine that is expressed primarily in activated T cells. Here we ide... | [
{
"id": "9047239_T1",
"type": "Protein",
"text": [
"interleukin-3"
],
"offsets": [
[
34,
47
]
],
"normalized": []
},
{
"id": "9047239_T2",
"type": "Protein",
"text": [
"Interleukin-3"
],
"offsets": [
[
145,
... | [
{
"id": "9047239_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"activated cooperatively"
],
"offsets": [
[
57,
80
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9047239_T1"
}
]
... | [
{
"id": "9047239_1",
"entity_ids": [
"9047239_T2",
"9047239_T3"
]
}
] | [] |
7826623 | 7826623 | [
{
"id": "7826623__text",
"type": "abstract",
"text": [
"T-cell functional regions of the human IL-3 proximal promoter. \nThe human interleukin-3 (IL-3) gene is expressed almost exclusively in activated T cells. Its expression is regulated at both the transcriptional and post-transcriptional level.... | [
{
"id": "7826623_T1",
"type": "Protein",
"text": [
"IL-3"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "7826623_T2",
"type": "Protein",
"text": [
"interleukin-3"
],
"offsets": [
[
74,
87
... | [
{
"id": "7826623_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expressed"
],
"offsets": [
[
103,
112
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7826623_T3"
}
]
},
{
"id"... | [
{
"id": "7826623_1",
"entity_ids": [
"7826623_T2",
"7826623_T3"
]
},
{
"id": "7826623_2",
"entity_ids": [
"7826623_T4",
"7826623_T5"
]
}
] | [] |
10327050 | 10327050 | [
{
"id": "10327050__text",
"type": "abstract",
"text": [
"Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. \nInitiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs... | [
{
"id": "10327050_T1",
"type": "Protein",
"text": [
"MCM5"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "10327050_T2",
"type": "Protein",
"text": [
"MCM6"
],
"offsets": [
[
55,
59
]
... | [
{
"id": "10327050_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulated"
],
"offsets": [
[
12,
21
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10327050_E4"
}
]
},
{
"id": "10... | [] | [] |
10200294 | 10200294 | [
{
"id": "10200294__text",
"type": "abstract",
"text": [
"A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. \nLipopolysaccharide (LPS) is a potent stimulator of... | [
{
"id": "10200294_T1",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offsets": [
[
67,
94
]
],
"normalized": []
},
{
"id": "10200294_T2",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offset... | [
{
"id": "10200294_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulating"
],
"offsets": [
[
56,
66
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10200294_E2"
}
]
},
{
"id": "1... | [
{
"id": "10200294_1",
"entity_ids": [
"10200294_T8",
"10200294_T9"
]
},
{
"id": "10200294_2",
"entity_ids": [
"10200294_T2",
"10200294_T3"
]
}
] | [] |
1946356 | 1946356 | [
{
"id": "1946356__text",
"type": "abstract",
"text": [
"Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer. \nAlthough monocytic cells can provide a reservoir for viral production in vivo, their regulation of human im... | [
{
"id": "1946356_T1",
"type": "Protein",
"text": [
"65-kDa"
],
"offsets": [
[
96,
102
]
],
"normalized": []
},
{
"id": "1946356_T2",
"type": "Protein",
"text": [
"50-kDa"
],
"offsets": [
[
108,
114
... | [
{
"id": "1946356_E1",
"type": "Binding",
"trigger": {
"text": [
"heterodimer"
],
"offsets": [
[
725,
736
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "1946356_T3"
},
{
"role": "The... | [] | [] |
9819151 | 9819151 | [
{
"id": "9819151__text",
"type": "abstract",
"text": [
"Transcription factor NF-kappaB regulation of renal fibrosis during ureteral obstruction. \nIrrespective of the etiology, many kidney diseases result in inflammation and fibrosis of the tubulointerstitium, with the subsequent loss of renal fun... | [] | [] | [] | [] |
9219058 | 9219058 | [
{
"id": "9219058__text",
"type": "abstract",
"text": [
"Association between expression of intercellular adhesion molecule-1 and integration of human T-cell-leukemia virus type 1 in adult T-cell leukemia cells. \nIt is known that the expression levels of intercellular adhesion molecule-1 (ICAM-1) i... | [
{
"id": "9219058_T1",
"type": "Protein",
"text": [
"intercellular adhesion molecule-1"
],
"offsets": [
[
34,
67
]
],
"normalized": []
},
{
"id": "9219058_T2",
"type": "Protein",
"text": [
"intercellular adhesion molecule-1"
],
... | [
{
"id": "9219058_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
20,
30
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9219058_T1"
}
]
},
{
"id":... | [
{
"id": "9219058_1",
"entity_ids": [
"9219058_T2",
"9219058_T3"
]
}
] | [] |
9185506 | 9185506 | [
{
"id": "9185506__text",
"type": "abstract",
"text": [
"Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras. \nGiant cell arteritis (GCA) is a vasculitic syndrome that preferentially affects medium and large-sized arteries. Glucocorticoid therapy reso... | [
{
"id": "9185506_T1",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
913,
917
]
],
"normalized": []
},
{
"id": "9185506_T2",
"type": "Protein",
"text": [
"IL-1beta"
],
"offsets": [
[
919,
927
... | [
{
"id": "9185506_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"reduced"
],
"offsets": [
[
880,
887
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9185506_T2"
}
]
},
{
"i... | [] | [] |
8761381 | 8761381 | [
{
"id": "8761381__text",
"type": "abstract",
"text": [
"Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells. \nAlthough case-oriented evidence for an association of Epstein-Barr virus (EBV) with gastric carcinom... | [
{
"id": "8761381_T1",
"type": "Protein",
"text": [
"EBV nuclear antigen (EBNA) 1"
],
"offsets": [
[
669,
697
]
],
"normalized": []
},
{
"id": "8761381_T2",
"type": "Protein",
"text": [
"EBNA2"
],
"offsets": [
[
... | [
{
"id": "8761381_E1",
"type": "Transcription",
"trigger": {
"text": [
"expressed"
],
"offsets": [
[
659,
668
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8761381_T2"
}
]
},
{
"id": ... | [] | [] |
8652841 | 8652841 | [
{
"id": "8652841__text",
"type": "abstract",
"text": [
"BCL-6 expression during B-cell activation. \nTranslocations involving the BCL-6 gene are common in the diffuse large cell subtype of non-Hodgkin's lymphoma. Invariably, the BCL-6 coding region is intact, but its 5' untranslated region is repl... | [
{
"id": "8652841_T1",
"type": "Protein",
"text": [
"BCL-6"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "8652841_T2",
"type": "Protein",
"text": [
"BCL-6"
],
"offsets": [
[
73,
78
]
... | [
{
"id": "8652841_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
6,
16
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8652841_T1"
}
]
},
{
"id": ... | [] | [] |
9743506 | 9743506 | [
{
"id": "9743506__text",
"type": "abstract",
"text": [
"Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells [see comments] \nBACKGROUND: Platelet/endothelium interaction plays an important role in the ... | [
{
"id": "9743506_T1",
"type": "Protein",
"text": [
"monocyte chemotactic protein-1"
],
"offsets": [
[
27,
57
]
],
"normalized": []
},
{
"id": "9743506_T2",
"type": "Protein",
"text": [
"intercellular adhesion molecule-1"
],
... | [
{
"id": "9743506_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"induce"
],
"offsets": [
[
20,
26
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9743506_E3"
}
]
},
{
"id":... | [
{
"id": "9743506_1",
"entity_ids": [
"9743506_T5",
"9743506_T6"
]
},
{
"id": "9743506_2",
"entity_ids": [
"9743506_T3",
"9743506_T4"
]
}
] | [] |
7998962 | 7998962 | [
{
"id": "7998962__text",
"type": "abstract",
"text": [
"Constitutive nuclear NF-kappa B in cells of the monocyte lineage. \nIn monocytes, the nuclear factor NF-kappa B has been invoked as an important transcription factor in the expression of cytokine genes, of cell-surface receptors and in the ex... | [
{
"id": "7998962_T1",
"type": "Protein",
"text": [
"p50 subunit"
],
"offsets": [
[
924,
935
]
],
"normalized": []
},
{
"id": "7998962_T2",
"type": "Protein",
"text": [
"interleukin 6"
],
"offsets": [
[
2215,
... | [] | [] | [] |
8804437 | 8804437 | [
{
"id": "8804437__text",
"type": "abstract",
"text": [
"Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism. \nThe Id family of helix-loop-helix proteins function as negative regulators of DNA binding, basic helix-loop-helix p... | [
{
"id": "8804437_T1",
"type": "Protein",
"text": [
"Id-3"
],
"offsets": [
[
71,
75
]
],
"normalized": []
},
{
"id": "8804437_T2",
"type": "Protein",
"text": [
"Id-3"
],
"offsets": [
[
374,
378
]
... | [
{
"id": "8804437_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Attenuated function"
],
"offsets": [
[
0,
19
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8804437_T1"
}
]
},
... | [] | [] |
10029589 | 10029589 | [
{
"id": "10029589__text",
"type": "abstract",
"text": [
"The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade. \nThe alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, ... | [
{
"id": "10029589_T1",
"type": "Protein",
"text": [
"alpha2 integrin"
],
"offsets": [
[
316,
331
]
],
"normalized": []
},
{
"id": "10029589_T2",
"type": "Protein",
"text": [
"alpha2 integrin"
],
"offsets": [
[
... | [
{
"id": "10029589_E1",
"type": "Regulation",
"trigger": {
"text": [
"Transcriptional regulation"
],
"offsets": [
[
282,
308
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10029589_T1"
}
]
}... | [] | [] |
7935451 | 7935451 | [
{
"id": "7935451__text",
"type": "abstract",
"text": [
"Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene. \nThe tax gene product of human T-cell leukemia virus type I ... | [
{
"id": "7935451_T1",
"type": "Protein",
"text": [
"Tax"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "7935451_T2",
"type": "Protein",
"text": [
"I kappa B alpha"
],
"offsets": [
[
112,
127... | [
{
"id": "7935451_E1",
"type": "Phosphorylation",
"trigger": {
"text": [
"phosphorylation"
],
"offsets": [
[
77,
92
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7935451_T2"
}
]
},
{
... | [
{
"id": "7935451_1",
"entity_ids": [
"7935451_T3",
"7935451_T4"
]
},
{
"id": "7935451_2",
"entity_ids": [
"7935451_T16",
"7935451_T17"
]
}
] | [] |
9053449 | 9053449 | [
{
"id": "9053449__text",
"type": "abstract",
"text": [
"Involvement of Egr-1/RelA synergy in distinguishing T cell activation from tumor necrosis factor-alpha-induced NF-kappa B1 transcription. \nNF-kappa B is an important transcription factor required for T cell proliferation and other immunologi... | [
{
"id": "9053449_T1",
"type": "Protein",
"text": [
"Egr-1"
],
"offsets": [
[
15,
20
]
],
"normalized": []
},
{
"id": "9053449_T2",
"type": "Protein",
"text": [
"RelA"
],
"offsets": [
[
21,
25
]
... | [
{
"id": "9053449_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"induced"
],
"offsets": [
[
103,
110
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9053449_E2"
},
{
"rol... | [
{
"id": "9053449_1",
"entity_ids": [
"9053449_T7",
"9053449_T8"
]
}
] | [] |
2122173 | 2122173 | [
{
"id": "2122173__text",
"type": "abstract",
"text": [
"Interferon-gamma and the sexual dimorphism of autoimmunity. \nThe sexual difference in the incidence of autoimmune diseases has remained an enigma for many years. In the examination of the induction of autoimmunity in transgenic mice, evidenc... | [
{
"id": "2122173_T1",
"type": "Protein",
"text": [
"Interferon-gamma"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "2122173_T2",
"type": "Protein",
"text": [
"interferon-gamma"
],
"offsets": [
[
296... | [
{
"id": "2122173_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulation"
],
"offsets": [
[
358,
368
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "2122173_E2"
}
]
},
{
"id": "2... | [] | [] |
9261367 | 9261367 | [
{
"id": "9261367__text",
"type": "abstract",
"text": [
"Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists. \nHuman immunodeficiency virus type 1 (HIV-1) Tat, an early regulatory protein that... | [
{
"id": "9261367_T1",
"type": "Protein",
"text": [
"Tat"
],
"offsets": [
[
102,
105
]
],
"normalized": []
},
{
"id": "9261367_T2",
"type": "Protein",
"text": [
"Tat"
],
"offsets": [
[
204,
207
]
... | [
{
"id": "9261367_E1",
"type": "Binding",
"trigger": {
"text": [
"binding"
],
"offsets": [
[
357,
364
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9261367_T2"
}
]
}
] | [] | [] |
9209284 | 9209284 | [
{
"id": "9209284__text",
"type": "abstract",
"text": [
"AP-1 derived from mature monocytes and astrocytes preferentially interacts with the HTLV-I promoter central 21 bp repeat. \nCharacterization of the cellular transcription factors interacting with the human T cell lymphotropic virus type I (HT... | [] | [] | [] | [] |
1313226 | 1313226 | [
{
"id": "1313226__text",
"type": "abstract",
"text": [
"Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes. \nWe have examined the effect of leukotriene B4 (LTB4), a potent lipid proinflammatory mediator, on the expression of the proto-oncogen... | [
{
"id": "1313226_T1",
"type": "Protein",
"text": [
"c-fos"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "1313226_T2",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
36,
41
]
... | [
{
"id": "1313226_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"stimulates"
],
"offsets": [
[
15,
25
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "1313226_E4"
}
]
},
{
"... | [] | [] |
2407588 | 2407588 | [
{
"id": "2407588__text",
"type": "abstract",
"text": [
"Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression. \nAntibodies are produced exclusively in B lymphocytes. The expression of the antibody-encoding genes, the immunoglobulin (Ig) genes, is also restr... | [
{
"id": "2407588_T1",
"type": "Protein",
"text": [
"Oct-1"
],
"offsets": [
[
539,
544
]
],
"normalized": []
},
{
"id": "2407588_T2",
"type": "Protein",
"text": [
"Oct-2A"
],
"offsets": [
[
607,
613
... | [
{
"id": "2407588_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"present"
],
"offsets": [
[
556,
563
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "2407588_T1"
}
]
},
{
"id": ... | [] | [] |
8605348 | 8605348 | [
{
"id": "8605348__text",
"type": "abstract",
"text": [
"Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. \nInterleukin-13 (IL-13) and IL-4 are cytokines produced by T cells that are encoded b... | [
{
"id": "8605348_T1",
"type": "Protein",
"text": [
"interleukin-13"
],
"offsets": [
[
20,
34
]
],
"normalized": []
},
{
"id": "8605348_T2",
"type": "Protein",
"text": [
"interleukin-4"
],
"offsets": [
[
39,
... | [
{
"id": "8605348_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"Coexpression"
],
"offsets": [
[
0,
12
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8605348_T2"
}
]
},
{
"id"... | [
{
"id": "8605348_1",
"entity_ids": [
"8605348_T3",
"8605348_T4"
]
}
] | [] |
8668213 | 8668213 | [
{
"id": "8668213__text",
"type": "abstract",
"text": [
"Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. \nTranscription factors of the NFAT family play a key role in the transcription of cytokine genes and other genes during th... | [
{
"id": "8668213_T1",
"type": "Protein",
"text": [
"NFAT1"
],
"offsets": [
[
12,
17
]
],
"normalized": []
},
{
"id": "8668213_T2",
"type": "Protein",
"text": [
"NFATp"
],
"offsets": [
[
19,
24
]
... | [
{
"id": "8668213_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expressed"
],
"offsets": [
[
1104,
1113
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8668213_T9"
}
]
},
{
"i... | [
{
"id": "8668213_1",
"entity_ids": [
"8668213_T1",
"8668213_T2"
]
}
] | [] |
9817603 | 9817603 | [
{
"id": "9817603__text",
"type": "abstract",
"text": [
"Transcriptional regulation of the beta-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules. \nThe beta-casein promoter has been widely used to monitor the activation of STAT (signal transducer and activator of tra... | [
{
"id": "9817603_T1",
"type": "Protein",
"text": [
"beta-casein"
],
"offsets": [
[
34,
45
]
],
"normalized": []
},
{
"id": "9817603_T2",
"type": "Protein",
"text": [
"STAT5"
],
"offsets": [
[
84,
89
... | [
{
"id": "9817603_E1",
"type": "Regulation",
"trigger": {
"text": [
"Transcriptional regulation"
],
"offsets": [
[
0,
26
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9817603_T1"
}
]
},
{... | [
{
"id": "9817603_1",
"entity_ids": [
"9817603_T19",
"9817603_T20"
]
},
{
"id": "9817603_2",
"entity_ids": [
"9817603_T21",
"9817603_T22"
]
},
{
"id": "9817603_3",
"entity_ids": [
"9817603_T12",
"9817603_T13"
]
}
] | [] |
9634075 | 9634075 | [
{
"id": "9634075__text",
"type": "abstract",
"text": [
"Mycobacterium tuberculosis mannose-capped lipoarabinomannan can induce NF-kappaB-dependent activation of human immunodeficiency virus type 1 long terminal repeat in T cells. \nTuberculosis has emerged as an epidemic, extended by the large num... | [
{
"id": "9634075_T1",
"type": "Protein",
"text": [
"CD4"
],
"offsets": [
[
658,
661
]
],
"normalized": []
},
{
"id": "9634075_T2",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
[
1773,
1782
... | [
{
"id": "9634075_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expressing"
],
"offsets": [
[
662,
672
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9634075_T1"
}
]
}
] | [] | [] |
9974401 | 9974401 | [
{
"id": "9974401__text",
"type": "abstract",
"text": [
"Oleic acid inhibits endothelial activation : A direct vascular antiatherogenic mechanism of a nutritional component in the mediterranean diet. \nBecause oleic acid is implicated in the antiatherogenic effects attributed to the Mediterranean d... | [
{
"id": "9974401_T1",
"type": "Protein",
"text": [
"interleukin (IL)-1alpha"
],
"offsets": [
[
599,
622
]
],
"normalized": []
},
{
"id": "9974401_T2",
"type": "Protein",
"text": [
"IL-1beta"
],
"offsets": [
[
6... | [
{
"id": "9974401_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
763,
773
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9974401_T6"
}
]
},
{
"id... | [
{
"id": "9974401_1",
"entity_ids": [
"9974401_T4",
"9974401_T5"
]
}
] | [] |
7917514 | 7917514 | [
{
"id": "7917514__text",
"type": "abstract",
"text": [
"Role of HIV-1 Nef expression in activation pathways in CD4+ T cells. \nThe role of the human immunodeficiency virus (HIV-1) Nef protein in T cell activation pathways was investigated using a Jurkat CD4+ cell line stably transfected with a Nef... | [
{
"id": "7917514_T1",
"type": "Protein",
"text": [
"Nef"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "7917514_T2",
"type": "Protein",
"text": [
"CD4"
],
"offsets": [
[
55,
58
]
]... | [
{
"id": "7917514_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
18,
28
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7917514_T1"
}
]
},
{
"id":... | [] | [] |
9177217 | 9177217 | [
{
"id": "9177217__text",
"type": "abstract",
"text": [
"Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. \nTwo of the genes defective in the five complementation groups identified in the class II-negative bare lymphocyte syndrome or... | [
{
"id": "9177217_T1",
"type": "Protein",
"text": [
"CIITA"
],
"offsets": [
[
99,
104
]
],
"normalized": []
},
{
"id": "9177217_T2",
"type": "Protein",
"text": [
"RFX5"
],
"offsets": [
[
109,
113
]... | [
{
"id": "9177217_E1",
"type": "Binding",
"trigger": {
"text": [
"complex formation"
],
"offsets": [
[
9,
26
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9177217_T1"
},
{
"role": "... | [] | [] |
10383397 | 10383397 | [
{
"id": "10383397__text",
"type": "abstract",
"text": [
"3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. \nPreviously we reported that 3-deazaadenos... | [
{
"id": "10383397_T1",
"type": "Protein",
"text": [
"S-adenosylhomocysteine hydrolase"
],
"offsets": [
[
20,
52
]
],
"normalized": []
},
{
"id": "10383397_T2",
"type": "Protein",
"text": [
"IkappaBalpha"
],
"offsets": [
... | [
{
"id": "10383397_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibitor"
],
"offsets": [
[
53,
62
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10383397_T1"
}
]
},
{
... | [
{
"id": "10383397_1",
"entity_ids": [
"10383397_T6",
"10383397_T7"
]
}
] | [] |
7594540 | 7594540 | [
{
"id": "7594540__text",
"type": "abstract",
"text": [
"Nuclear factor-IL6 activates the human IL-4 promoter in T cells. \nPositive regulatory element I (PRE-I) is a strong enhancer element essential for expression of the human IL-4 gene. To identify transcription factors binding to PRE-I, we scre... | [
{
"id": "7594540_T1",
"type": "Protein",
"text": [
"Nuclear factor-IL6"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "7594540_T2",
"type": "Protein",
"text": [
"IL-4"
],
"offsets": [
[
39,
4... | [
{
"id": "7594540_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"activates"
],
"offsets": [
[
19,
28
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7594540_T2"
},
{
"rol... | [
{
"id": "7594540_1",
"entity_ids": [
"7594540_T4",
"7594540_T5"
]
}
] | [] |
7923175 | 7923175 | [
{
"id": "7923175__text",
"type": "abstract",
"text": [
"T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity: a preliminary report. \nRecent data suggest that the poor induction of a T-cell response to human renal cell carcinoma (RCC) may ... | [
{
"id": "7923175_T1",
"type": "Protein",
"text": [
"NF-kappa B1"
],
"offsets": [
[
960,
971
]
],
"normalized": []
},
{
"id": "7923175_T2",
"type": "Protein",
"text": [
"p50"
],
"offsets": [
[
973,
976
... | [
{
"id": "7923175_E1",
"type": "Binding",
"trigger": {
"text": [
"binding activity"
],
"offsets": [
[
863,
879
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7923175_T1"
}
]
},
{
"id":... | [
{
"id": "7923175_1",
"entity_ids": [
"7923175_T1",
"7923175_T2"
]
}
] | [] |
8691127 | 8691127 | [
{
"id": "8691127__text",
"type": "abstract",
"text": [
"Mechanisms of transactivation by nuclear factor of activated T cells-1. \nNuclear factor of activated T cells-family proteins (NFAT1/NFATp, NFATc, NFAT3, and NFAT4/NFATx/NFATc3) play a key role in the transcription of cytokine genes and other... | [
{
"id": "8691127_T1",
"type": "Protein",
"text": [
"nuclear factor of activated T cells-1"
],
"offsets": [
[
33,
70
]
],
"normalized": []
},
{
"id": "8691127_T2",
"type": "Protein",
"text": [
"NFAT1"
],
"offsets": [
[
... | [
{
"id": "8691127_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expressed"
],
"offsets": [
[
575,
584
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8691127_T10"
}
]
}
] | [
{
"id": "8691127_1",
"entity_ids": [
"8691127_T2",
"8691127_T3"
]
},
{
"id": "8691127_2",
"entity_ids": [
"8691127_T6",
"8691127_T7",
"8691127_T8"
]
}
] | [] |
7542286 | 7542286 | [
{
"id": "7542286__text",
"type": "abstract",
"text": [
"Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. \nTo test the hypothesis that nitric oxide (NO) limits endothelial ac... | [
{
"id": "7542286_T1",
"type": "Protein",
"text": [
"vascular cell adhesion molecule-1"
],
"offsets": [
[
402,
435
]
],
"normalized": []
},
{
"id": "7542286_T2",
"type": "Protein",
"text": [
"VCAM-1"
],
"offsets": [
[
... | [
{
"id": "7542286_E1",
"type": "Regulation",
"trigger": {
"text": [
"effects"
],
"offsets": [
[
363,
370
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7542286_E3"
}
]
},
{
"id": "7542... | [
{
"id": "7542286_1",
"entity_ids": [
"7542286_T8",
"7542286_T9"
]
},
{
"id": "7542286_2",
"entity_ids": [
"7542286_T1",
"7542286_T2"
]
}
] | [] |
8186461 | 8186461 | [
{
"id": "8186461__text",
"type": "abstract",
"text": [
"Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells: involvement of the conserved lymphokine element 0. \nGranulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2... | [
{
"id": "8186461_T1",
"type": "Protein",
"text": [
"granulocyte-macrophage colony-stimulating factor"
],
"offsets": [
[
42,
90
]
],
"normalized": []
},
{
"id": "8186461_T2",
"type": "Protein",
"text": [
"Granulocyte-macrophage colon... | [
{
"id": "8186461_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"potentiates"
],
"offsets": [
[
12,
23
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8186461_E2"
}
]
},
{
... | [
{
"id": "8186461_1",
"entity_ids": [
"8186461_T2",
"8186461_T3"
]
},
{
"id": "8186461_2",
"entity_ids": [
"8186461_T4",
"8186461_T5"
]
}
] | [] |
9741337 | 9741337 | [
{
"id": "9741337__text",
"type": "abstract",
"text": [
"Low CD3+CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells. \nThe capacity of neonatal T cells to secrete interleukin-2 (IL-2) has been reported to be variable. We analys... | [
{
"id": "9741337_T1",
"type": "Protein",
"text": [
"CD28"
],
"offsets": [
[
8,
12
]
],
"normalized": []
},
{
"id": "9741337_T2",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
21,
34
... | [
{
"id": "9741337_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"induced"
],
"offsets": [
[
13,
20
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9741337_E2"
},
{
"role"... | [
{
"id": "9741337_1",
"entity_ids": [
"9741337_T3",
"9741337_T4"
]
}
] | [] |
7534663 | 7534663 | [
{
"id": "7534663__text",
"type": "abstract",
"text": [
"Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells. \nBACKGROUND: The induction of vascular cell adhesion molecule-1 (VCAM-1) and E-selectin by tumor necrosis factor-alpha (TNF) is... | [
{
"id": "7534663_T1",
"type": "Protein",
"text": [
"vascular cell adhesion molecule-1"
],
"offsets": [
[
144,
177
]
],
"normalized": []
},
{
"id": "7534663_T2",
"type": "Protein",
"text": [
"VCAM-1"
],
"offsets": [
[
... | [
{
"id": "7534663_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"induction"
],
"offsets": [
[
131,
140
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7534663_T3"
},
{
"r... | [
{
"id": "7534663_1",
"entity_ids": [
"7534663_T1",
"7534663_T2"
]
},
{
"id": "7534663_2",
"entity_ids": [
"7534663_T4",
"7534663_T5"
]
},
{
"id": "7534663_3",
"entity_ids": [
"7534663_T10",
"7534663_T11"
]
}
] | [] |
7931077 | 7931077 | [
{
"id": "7931077__text",
"type": "abstract",
"text": [
"A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells. \nTwo groups of U937 pr... | [
{
"id": "7931077_T1",
"type": "Protein",
"text": [
"p65"
],
"offsets": [
[
134,
137
]
],
"normalized": []
},
{
"id": "7931077_T2",
"type": "Protein",
"text": [
"p50"
],
"offsets": [
[
668,
671
]
... | [
{
"id": "7931077_E1",
"type": "Localization",
"trigger": {
"text": [
"liberated"
],
"offsets": [
[
644,
653
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7931077_T3"
}
]
},
{
"id": "... | [] | [] |
9344365 | 9344365 | [
{
"id": "9344365__text",
"type": "abstract",
"text": [
"Suppression of nuclear factor kappa B and CD18-mediated leukocyte adhesion to the corneal endothelium by dexamethasone. \nPURPOSE: To demonstrate that leukocyte adhesion to cultured corneal endothelial cells is mediated by the CD18 antigen, a... | [
{
"id": "9344365_T1",
"type": "Protein",
"text": [
"CD18"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "9344365_T2",
"type": "Protein",
"text": [
"CD18"
],
"offsets": [
[
226,
230
]
... | [
{
"id": "9344365_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expressed"
],
"offsets": [
[
1888,
1897
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9344365_T12"
}
]
}
] | [
{
"id": "9344365_1",
"entity_ids": [
"9344365_T3",
"9344365_T4"
]
}
] | [] |
9882331 | 9882331 | [
{
"id": "9882331__text",
"type": "abstract",
"text": [
"Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. \nHuman T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be ... | [
{
"id": "9882331_T1",
"type": "Protein",
"text": [
"tax"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "9882331_T2",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
57,
70
... | [
{
"id": "9882331_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
489,
499
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9882331_T7"
}
]
}
] | [
{
"id": "9882331_1",
"entity_ids": [
"9882331_T5",
"9882331_T6"
]
}
] | [] |
7864072 | 7864072 | [
{
"id": "7864072__text",
"type": "abstract",
"text": [
"Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells. \nGlucocorticoids have an inhibitory effect on inflammatory and immune responses, and this may be through the modulation of transcripti... | [
{
"id": "7864072_T1",
"type": "Protein",
"text": [
"glucocorticoid receptors"
],
"offsets": [
[
442,
466
]
],
"normalized": []
},
{
"id": "7864072_T2",
"type": "Protein",
"text": [
"GR"
],
"offsets": [
[
468,
... | [
{
"id": "7864072_E1",
"type": "Binding",
"trigger": {
"text": [
"interaction"
],
"offsets": [
[
271,
282
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7864072_T2"
}
]
},
{
"id": "786... | [
{
"id": "7864072_1",
"entity_ids": [
"7864072_T1",
"7864072_T2"
]
}
] | [] |
10210321 | 10210321 | [
{
"id": "10210321__text",
"type": "abstract",
"text": [
"Unexpected and coordinated expression of Spi-1, Fli-1, and megakaryocytic genes in four Epo-dependent cell lines established from transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen. \nMost erythroleu... | [
{
"id": "10210321_T1",
"type": "Protein",
"text": [
"Spi-1"
],
"offsets": [
[
41,
46
]
],
"normalized": []
},
{
"id": "10210321_T2",
"type": "Protein",
"text": [
"Fli-1"
],
"offsets": [
[
48,
53
]... | [
{
"id": "10210321_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
27,
37
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10210321_T2"
}
]
},
{
"id... | [] | [] |
10349513 | 10349513 | [
{
"id": "10349513__text",
"type": "abstract",
"text": [
"Targeted remodeling of human beta-globin promoter chromatin structure produces increased expression and decreased silencing. \nThe chromatin structure of the human beta-globin gene locus assumes a transcriptionally-active conformation in ery... | [
{
"id": "10349513_T1",
"type": "Protein",
"text": [
"beta-globin"
],
"offsets": [
[
29,
40
]
],
"normalized": []
},
{
"id": "10349513_T2",
"type": "Protein",
"text": [
"beta-globin"
],
"offsets": [
[
163,
... | [
{
"id": "10349513_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"increased"
],
"offsets": [
[
79,
88
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10349513_E2"
}
]
},
{
... | [] | [] |
8796372 | 8796372 | [
{
"id": "8796372__text",
"type": "abstract",
"text": [
"Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging. \nTranscription factor NF kappa B (nuclear factor kappa B) is induced in T lymphocytes from young individuals following activation with a ... | [
{
"id": "8796372_T1",
"type": "Protein",
"text": [
"tumor necrosis factor-alpha"
],
"offsets": [
[
317,
344
]
],
"normalized": []
},
{
"id": "8796372_T2",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
[
... | [
{
"id": "8796372_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"be the predominant subunits"
],
"offsets": [
[
658,
685
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8796372_T4"
}
... | [
{
"id": "8796372_1",
"entity_ids": [
"8796372_T1",
"8796372_T2"
]
}
] | [] |
7670114 | 7670114 | [
{
"id": "7670114__text",
"type": "abstract",
"text": [
"The hematopoietic transcription factor PU.1 is downregulated in human multiple myeloma cell lines. \nPU.1 is a hematopoietic transcription factor belonging to the Ets-family. It is identical to the Spi-1 oncogene, which is implicated in splee... | [
{
"id": "7670114_T1",
"type": "Protein",
"text": [
"PU.1"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "7670114_T2",
"type": "Protein",
"text": [
"PU.1"
],
"offsets": [
[
100,
104
]
... | [
{
"id": "7670114_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"downregulated"
],
"offsets": [
[
47,
60
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7670114_T1"
}
]
},
{
... | [] | [] |
7589085 | 7589085 | [
{
"id": "7589085__text",
"type": "abstract",
"text": [
"CD30 ligation induces nuclear factor-kappa B activation in human T cell lines. \nCD30 is a recently described member of the tumor necrosis factor/nerve growth factor receptor superfamily. In this report, we show that following incubation of L... | [
{
"id": "7589085_T1",
"type": "Protein",
"text": [
"CD30"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "7589085_T2",
"type": "Protein",
"text": [
"CD30"
],
"offsets": [
[
80,
84
]
]... | [
{
"id": "7589085_E1",
"type": "Binding",
"trigger": {
"text": [
"ligation"
],
"offsets": [
[
5,
13
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7589085_T1"
}
]
},
{
"id": "7589085_E... | [] | [] |
2237444 | 2237444 | [
{
"id": "2237444__text",
"type": "abstract",
"text": [
"Regulation of gene expression with double-stranded phosphorothioate oligonucleotides. \nAlteration of gene transcription by inhibition of specific transcriptional regulatory proteins is necessary for determining how these factors participate ... | [
{
"id": "2237444_T1",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
1210,
1223
]
],
"normalized": []
},
{
"id": "2237444_T2",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
1225,
... | [
{
"id": "2237444_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibited"
],
"offsets": [
[
1200,
1209
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "2237444_E3"
},
{
... | [
{
"id": "2237444_1",
"entity_ids": [
"2237444_T1",
"2237444_T2"
]
}
] | [] |
9722600 | 9722600 | [
{
"id": "9722600__text",
"type": "abstract",
"text": [
"Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line. \nThe human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia. Although the exa... | [
{
"id": "9722600_T1",
"type": "Protein",
"text": [
"Tax"
],
"offsets": [
[
79,
82
]
],
"normalized": []
},
{
"id": "9722600_T2",
"type": "Protein",
"text": [
"p16"
],
"offsets": [
[
96,
99
]
]... | [
{
"id": "9722600_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"negative"
],
"offsets": [
[
107,
115
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9722600_T3"
}
]
},
{
"id":... | [] | [] |
9095577 | 9095577 | [
{
"id": "9095577__text",
"type": "abstract",
"text": [
"Oxidant-regulation of gene expression in the chronically inflamed intestine. \nIt is becoming increasingly apparent that the chronic gut inflammation observed in the idiopathic inflammatory bowel diseases (e.g. ulcerative colitis, Crohn's dis... | [
{
"id": "9095577_T1",
"type": "Protein",
"text": [
"ICAM-1"
],
"offsets": [
[
905,
911
]
],
"normalized": []
},
{
"id": "9095577_T2",
"type": "Protein",
"text": [
"VCAM-1"
],
"offsets": [
[
913,
919
... | [
{
"id": "9095577_E1",
"type": "Regulation",
"trigger": {
"text": [
"upregulates"
],
"offsets": [
[
834,
845
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9095577_E5"
}
]
},
{
"id": "... | [] | [] |
10194443 | 10194443 | [
{
"id": "10194443__text",
"type": "abstract",
"text": [
"Regulation of the megakaryocytic glycoprotein IX promoter by the oncogenic Ets transcription factor Fli-1. \nGlycoprotein (GP) IX is a subunit of the von Willebrand receptor, GPIb-V-IX, which mediates adhesion of platelets to the subendothel... | [
{
"id": "10194443_T1",
"type": "Protein",
"text": [
"glycoprotein IX"
],
"offsets": [
[
33,
48
]
],
"normalized": []
},
{
"id": "10194443_T2",
"type": "Protein",
"text": [
"Fli-1"
],
"offsets": [
[
100,
... | [
{
"id": "10194443_E1",
"type": "Regulation",
"trigger": {
"text": [
"Regulation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10194443_T1"
},
{
"role": "Ca... | [] | [] |
8699118 | 8699118 | [
{
"id": "8699118__text",
"type": "abstract",
"text": [
"Constitutive expression of specific interferon isotypes in peripheral blood leukocytes from normal individuals and in promonocytic U937 cells. \nConstitutive expression of IFN-alpha5 and IFN-beta was detected in different lymphoid cells inclu... | [
{
"id": "8699118_T1",
"type": "Protein",
"text": [
"IFN-alpha5"
],
"offsets": [
[
171,
181
]
],
"normalized": []
},
{
"id": "8699118_T2",
"type": "Protein",
"text": [
"IFN-beta"
],
"offsets": [
[
186,
1... | [
{
"id": "8699118_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
157,
167
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8699118_T1"
}
]
},
{
"id... | [] | [] |
7969146 | 7969146 | [
{
"id": "7969146__text",
"type": "abstract",
"text": [
"Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). \nThe receptor for the macrophage colony-stimulating facto... | [
{
"id": "7969146_T1",
"type": "Protein",
"text": [
"colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor"
],
"offsets": [
[
71,
146
]
],
"normalized": []
},
{
"id": "7969146_T2",
"type": "Protein",
"text": [
"... | [
{
"id": "7969146_E1",
"type": "Regulation",
"trigger": {
"text": [
"directs"
],
"offsets": [
[
33,
40
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7969146_T1"
},
{
"role": "Site",... | [] | [] |
8754855 | 8754855 | [
{
"id": "8754855__text",
"type": "abstract",
"text": [
"Precise alignment of sites required for mu enhancer activation in B cells. \nThe lymphocyte-specific immunoglobulin mu heavy-chain gene intronic enhancer is regulated by multiple nuclear factors. The previously defined minimal enhancer contai... | [
{
"id": "8754855_T1",
"type": "Protein",
"text": [
"PU.1"
],
"offsets": [
[
337,
341
]
],
"normalized": []
},
{
"id": "8754855_T2",
"type": "Protein",
"text": [
"Ets-1"
],
"offsets": [
[
346,
351
... | [
{
"id": "8754855_E1",
"type": "Binding",
"trigger": {
"text": [
"combination"
],
"offsets": [
[
298,
309
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8754855_T1"
},
{
"role": "The... | [] | [] |
9199464 | 9199464 | [
{
"id": "9199464__text",
"type": "abstract",
"text": [
"Anti-Ehrlichia chaffeensis antibody complexed with E. chaffeensis induces potent proinflammatory cytokine mRNA expression in human monocytes through sustained reduction of IkappaB-alpha and activation of NF-kappaB. \nEhrlichia chaffeensis is ... | [
{
"id": "9199464_T1",
"type": "Protein",
"text": [
"IkappaB-alpha"
],
"offsets": [
[
172,
185
]
],
"normalized": []
},
{
"id": "9199464_T2",
"type": "Protein",
"text": [
"interleukin-1beta"
],
"offsets": [
[
49... | [
{
"id": "9199464_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"reduction"
],
"offsets": [
[
159,
168
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9199464_T1"
}
]
},
{
... | [
{
"id": "9199464_1",
"entity_ids": [
"9199464_T2",
"9199464_T3"
]
},
{
"id": "9199464_2",
"entity_ids": [
"9199464_T6",
"9199464_T7"
]
}
] | [] |
2192264 | 2192264 | [
{
"id": "2192264__text",
"type": "abstract",
"text": [
"Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1. \nExpression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells bl... | [
{
"id": "2192264_T1",
"type": "Protein",
"text": [
"interleukin-1"
],
"offsets": [
[
91,
104
]
],
"normalized": []
},
{
"id": "2192264_T2",
"type": "Protein",
"text": [
"interleukin-1"
],
"offsets": [
[
201,
... | [] | [
{
"id": "2192264_1",
"entity_ids": [
"2192264_T2",
"2192264_T3"
]
}
] | [] |
9031085 | 9031085 | [
{
"id": "9031085__text",
"type": "abstract",
"text": [
"Expression of erythroid-specific genes in megakaryoblastic disorders. \nCurrently available data indicate that erythroid and megakaryocytic differentiation pathways are closely related to each other, and there may exist progenitor cells commo... | [
{
"id": "9031085_T1",
"type": "Protein",
"text": [
"GATA-1"
],
"offsets": [
[
553,
559
]
],
"normalized": []
},
{
"id": "9031085_T2",
"type": "Protein",
"text": [
"erythroid delta-aminolevulinate synthase"
],
"offsets": [
... | [
{
"id": "9031085_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"express"
],
"offsets": [
[
498,
505
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9031085_T1"
}
]
},
{
"id": ... | [
{
"id": "9031085_1",
"entity_ids": [
"9031085_T2",
"9031085_T3"
]
}
] | [] |
9764907 | 9764907 | [
{
"id": "9764907__text",
"type": "abstract",
"text": [
"Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells. \nCepharanthine is a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata and has been shown to ... | [
{
"id": "9764907_T1",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offsets": [
[
488,
515
]
],
"normalized": []
},
{
"id": "9764907_T2",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
[
... | [] | [
{
"id": "9764907_1",
"entity_ids": [
"9764907_T1",
"9764907_T2"
]
}
] | [] |
9311921 | 9311921 | [
{
"id": "9311921__text",
"type": "abstract",
"text": [
"NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. \nActivation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAM... | [
{
"id": "9311921_T1",
"type": "Protein",
"text": [
"CAML"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "9311921_T2",
"type": "Protein",
"text": [
"CAML"
],
"offsets": [
[
238,
242
]
... | [
{
"id": "9311921_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"overexpressed"
],
"offsets": [
[
334,
347
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9311921_T2"
}
]
},
{
... | [
{
"id": "9311921_1",
"entity_ids": [
"9311921_T2",
"9311921_T3"
]
},
{
"id": "9311921_2",
"entity_ids": [
"9311921_T5",
"9311921_T6"
]
}
] | [] |
9438495 | 9438495 | [
{
"id": "9438495__text",
"type": "abstract",
"text": [
"Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-kappa B activation. \nTumor necrosis factor (TNF)-alpha controls T-c... | [
{
"id": "9438495_T1",
"type": "Protein",
"text": [
"Tumor necrosis factor (TNF)-alpha"
],
"offsets": [
[
195,
228
]
],
"normalized": []
},
{
"id": "9438495_T2",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
... | [
{
"id": "9438495_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"produced"
],
"offsets": [
[
551,
559
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9438495_T4"
}
]
},
{
"id":... | [] | [] |
8139041 | 8139041 | [
{
"id": "8139041__text",
"type": "abstract",
"text": [
"A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1. \nAnalysis of the chromatin organization of the integrated human immunodeficiency virus type 1 (HIV... | [
{
"id": "8139041_T1",
"type": "Protein",
"text": [
"pol"
],
"offsets": [
[
94,
97
]
],
"normalized": []
},
{
"id": "8139041_T2",
"type": "Protein",
"text": [
"pol"
],
"offsets": [
[
345,
348
]
... | [
{
"id": "8139041_E1",
"type": "Binding",
"trigger": {
"text": [
"bound"
],
"offsets": [
[
1042,
1047
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8139041_T5"
}
]
},
{
"id": "8139041... | [
{
"id": "8139041_1",
"entity_ids": [
"8139041_T8",
"8139041_T9"
]
},
{
"id": "8139041_2",
"entity_ids": [
"8139041_T5",
"8139041_T6"
]
}
] | [] |
7858491 | 7858491 | [
{
"id": "7858491__text",
"type": "abstract",
"text": [
"Expression and genomic configuration of GM-CSF, IL-3, M-CSF receptor (C-FMS), early growth response gene-1 (EGR-1) and M-CSF genes in primary myelodysplastic syndromes. \nPeripheral blood mononuclear cells from seventeen patients with primary... | [
{
"id": "7858491_T1",
"type": "Protein",
"text": [
"GM-CSF"
],
"offsets": [
[
40,
46
]
],
"normalized": []
},
{
"id": "7858491_T2",
"type": "Protein",
"text": [
"IL-3"
],
"offsets": [
[
48,
52
]
... | [
{
"id": "7858491_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"Expression"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7858491_T2"
}
]
},
{
"id": ... | [
{
"id": "7858491_1",
"entity_ids": [
"7858491_T3",
"7858491_T4"
]
},
{
"id": "7858491_2",
"entity_ids": [
"7858491_T5",
"7858491_T6"
]
}
] | [] |
2123468 | 2123468 | [
{
"id": "2123468__text",
"type": "abstract",
"text": [
"Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. \nStimulation of T lymphocytes through their antigen receptor leads to the appearance of several... | [
{
"id": "2123468_T1",
"type": "Protein",
"text": [
"beta-galactosidase"
],
"offsets": [
[
550,
568
]
],
"normalized": []
},
{
"id": "2123468_T2",
"type": "Protein",
"text": [
"beta-gal"
],
"offsets": [
[
570,
... | [
{
"id": "2123468_E1",
"type": "Regulation",
"trigger": {
"text": [
"directs"
],
"offsets": [
[
761,
768
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "2123468_E2"
}
]
},
{
"id": "2123... | [
{
"id": "2123468_1",
"entity_ids": [
"2123468_T1",
"2123468_T2"
]
}
] | [] |
9919536 | 9919536 | [
{
"id": "9919536__text",
"type": "abstract",
"text": [
"Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasome. \nIt is becoming increasingly apparent that NF-kappa B plays a critical role in regulating the inflammatory response. Data obtained from studies in our laborato... | [] | [] | [] | [] |
1493333 | 1493333 | [
{
"id": "1493333__text",
"type": "abstract",
"text": [
"I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. \nThe active nuclear form of the NF-kappa B transcription factor complex is composed of two... | [
{
"id": "1493333_T1",
"type": "Protein",
"text": [
"MAD-3"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "1493333_T2",
"type": "Protein",
"text": [
"p65"
],
"offsets": [
[
68,
71
]
... | [
{
"id": "1493333_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"masks"
],
"offsets": [
[
16,
21
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "1493333_T2"
},
{
"role": ... | [] | [] |
7520093 | 7520093 | [
{
"id": "7520093__text",
"type": "abstract",
"text": [
"Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers. \nAn ability of the Epstein-Barr virus latent... | [
{
"id": "7520093_T1",
"type": "Protein",
"text": [
"bcl-2"
],
"offsets": [
[
16,
21
]
],
"normalized": []
},
{
"id": "7520093_T2",
"type": "Protein",
"text": [
"LMP1"
],
"offsets": [
[
72,
76
]
... | [
{
"id": "7520093_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"Upregulation"
],
"offsets": [
[
0,
12
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7520093_T1"
},
{
"r... | [] | [] |
7925300 | 7925300 | [
{
"id": "7925300__text",
"type": "abstract",
"text": [
"Activation of NF-kappa B in vivo is regulated by multiple phosphorylations. \nThe activation of nuclear factor kappa B (NF-kappa B) in intact cells is mechanistically not well understood. Therefore we investigated the modifications imposed on... | [
{
"id": "7925300_T1",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
[
484,
493
]
],
"normalized": []
},
{
"id": "7925300_T2",
"type": "Protein",
"text": [
"p50"
],
"offsets": [
[
545,
548
... | [
{
"id": "7925300_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"induced"
],
"offsets": [
[
502,
509
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7925300_E4"
},
{
"rol... | [] | [] |
10357820 | 10357820 | [
{
"id": "10357820__text",
"type": "abstract",
"text": [
"Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. \nHere we show that the lymphoid lineage-determining factors Ikaros and Aiolos can function as strong transcriptional repressors. This function is mediated th... | [
{
"id": "10357820_T1",
"type": "Protein",
"text": [
"Ikaros"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "10357820_T2",
"type": "Protein",
"text": [
"Aiolos"
],
"offsets": [
[
25,
31
... | [
{
"id": "10357820_E1",
"type": "Binding",
"trigger": {
"text": [
"interact"
],
"offsets": [
[
546,
554
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10357820_T6"
}
]
},
{
"id": "1035... | [] | [] |
10101034 | 10101034 | [
{
"id": "10101034__text",
"type": "abstract",
"text": [
"Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. \nThe therapeutic potential of drugs that block the induction of c... | [
{
"id": "10101034_T1",
"type": "Protein",
"text": [
"cyclooxygenase-2"
],
"offsets": [
[
14,
30
]
],
"normalized": []
},
{
"id": "10101034_T2",
"type": "Protein",
"text": [
"cyclooxygenase-2"
],
"offsets": [
[
... | [
{
"id": "10101034_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Inhibition"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10101034_E2"
}
]
},
{
... | [
{
"id": "10101034_1",
"entity_ids": [
"10101034_T3",
"10101034_T4"
]
}
] | [] |
10497131 | 10497131 | [
{
"id": "10497131__text",
"type": "abstract",
"text": [
"Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A [see comments] \nThe flow of information from calcium-mobilizing receptors to nuclear factor of activated T cells (NFAT)-dependent genes is critically d... | [] | [] | [] | [] |
9306134 | 9306134 | [
{
"id": "9306134__text",
"type": "abstract",
"text": [
"Abnormal apoptosis and cell cycle progression in humans exposed to methyl tertiary-butyl ether and benzene contaminating water. \n1. In this study we hypothesized that in individuals with certain genetic makeup, MTBE, benzene or their metabol... | [] | [] | [] | [] |
10352258 | 10352258 | [
{
"id": "10352258__text",
"type": "abstract",
"text": [
"In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis. \nTo understan... | [
{
"id": "10352258_T1",
"type": "Protein",
"text": [
"RelA"
],
"offsets": [
[
356,
360
]
],
"normalized": []
},
{
"id": "10352258_T2",
"type": "Protein",
"text": [
"c-Rel"
],
"offsets": [
[
365,
370
... | [
{
"id": "10352258_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibited"
],
"offsets": [
[
398,
407
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10352258_T1"
},
{
... | [] | [] |
8383677 | 8383677 | [
{
"id": "8383677__text",
"type": "abstract",
"text": [
"Stimulation of interleukin-1 alpha and interleukin-1 beta production in human monocytes by protein phosphatase 1 and 2A inhibitors. \nProtein phosphatases 1 and 2A are important in regulating cellular functions by controlling the phosphorylat... | [
{
"id": "8383677_T1",
"type": "Protein",
"text": [
"interleukin-1 alpha"
],
"offsets": [
[
15,
34
]
],
"normalized": []
},
{
"id": "8383677_T2",
"type": "Protein",
"text": [
"interleukin-1 beta"
],
"offsets": [
[
... | [
{
"id": "8383677_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Stimulation"
],
"offsets": [
[
0,
11
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8383677_E5"
},
{
"ro... | [] | [] |
10446999 | 10446999 | [
{
"id": "10446999__text",
"type": "abstract",
"text": [
"Induction of a functional vitamin D receptor in all-trans-retinoic acid-induced monocytic differentiation of M2-type leukemic blast cells. \nDifferent types of acute myeloid leukemia blast cells were induced to differentiate in vitro with al... | [
{
"id": "10446999_T1",
"type": "Protein",
"text": [
"vitamin D receptor"
],
"offsets": [
[
26,
44
]
],
"normalized": []
},
{
"id": "10446999_T2",
"type": "Protein",
"text": [
"VD receptor"
],
"offsets": [
[
976... | [
{
"id": "10446999_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"Induction"
],
"offsets": [
[
0,
9
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10446999_T1"
}
]
},
{
"i... | [
{
"id": "10446999_1",
"entity_ids": [
"10446999_T2",
"10446999_T3"
]
}
] | [] |
8015552 | 8015552 | [
{
"id": "8015552__text",
"type": "abstract",
"text": [
"Multiple prolactin-responsive elements mediate G1 and S phase expression of the interferon regulatory factor-1 gene. \nThe interferon regulatory factor-1 (IRF-1) gene is both an immediate-early G1 phase gene and an S phase gene inducible by P... | [
{
"id": "8015552_T1",
"type": "Protein",
"text": [
"prolactin"
],
"offsets": [
[
9,
18
]
],
"normalized": []
},
{
"id": "8015552_T2",
"type": "Protein",
"text": [
"interferon regulatory factor-1"
],
"offsets": [
[
... | [
{
"id": "8015552_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"mediate"
],
"offsets": [
[
39,
46
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8015552_E2"
}
]
},
{
"id"... | [
{
"id": "8015552_1",
"entity_ids": [
"8015552_T11",
"8015552_T12"
]
},
{
"id": "8015552_2",
"entity_ids": [
"8015552_T3",
"8015552_T4"
]
}
] | [] |
9032264 | 9032264 | [
{
"id": "9032264__text",
"type": "abstract",
"text": [
"Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor. \nChicken NF-M transcription factor, in cooperation with either c-Myb or v-Myb, is active in the combinatorial activation of myeloid-cell-specific genes in h... | [
{
"id": "9032264_T1",
"type": "Protein",
"text": [
"NF-M"
],
"offsets": [
[
94,
98
]
],
"normalized": []
},
{
"id": "9032264_T2",
"type": "Protein",
"text": [
"c-Myb"
],
"offsets": [
[
148,
153
]
... | [
{
"id": "9032264_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expressed"
],
"offsets": [
[
540,
549
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9032264_T6"
}
]
},
{
"id"... | [
{
"id": "9032264_1",
"entity_ids": [
"9032264_T3",
"9032264_T4",
"9032264_T5"
]
},
{
"id": "9032264_2",
"entity_ids": [
"9032264_T7",
"9032264_T8"
]
}
] | [] |
1628621 | 1628621 | [
{
"id": "1628621__text",
"type": "abstract",
"text": [
"Transcription factor AP-2 activates gene expression of HTLV-I. \nThe HTLV-I LTR contains three conserved regulatory elements known as 21 base pair repeats which are required for stimulation of gene expression by the transactivator protein tax... | [
{
"id": "1628621_T1",
"type": "Protein",
"text": [
"tax"
],
"offsets": [
[
238,
241
]
],
"normalized": []
},
{
"id": "1628621_T2",
"type": "Protein",
"text": [
"tax"
],
"offsets": [
[
375,
378
]
... | [
{
"id": "1628621_E1",
"type": "Regulation",
"trigger": {
"text": [
"influences the level"
],
"offsets": [
[
351,
371
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "1628621_E2"
}
]
},
{
... | [] | [] |
9122255 | 9122255 | [
{
"id": "9122255__text",
"type": "abstract",
"text": [
"Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression. \nNitric oxide subserves diverse physiologic roles in the nervous system. NO is produced from at leas... | [
{
"id": "9122255_T1",
"type": "Protein",
"text": [
"Neuronal (type I) nitric oxide synthase"
],
"offsets": [
[
0,
39
]
],
"normalized": []
},
{
"id": "9122255_T2",
"type": "Protein",
"text": [
"immunologic (type II) nitric oxide syn... | [
{
"id": "9122255_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulates"
],
"offsets": [
[
40,
49
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9122255_E2"
},
{
"role": "Caus... | [
{
"id": "9122255_1",
"entity_ids": [
"9122255_T3",
"9122255_T4"
]
},
{
"id": "9122255_2",
"entity_ids": [
"9122255_T10",
"9122255_T11"
]
},
{
"id": "9122255_3",
"entity_ids": [
"9122255_T6",
"9122255_T7"
]
}
] | [] |
9428793 | 9428793 | [
{
"id": "9428793__text",
"type": "abstract",
"text": [
"Cyclosporin A inhibits early mRNA expression of G0/G1 switch gene 2 (G0S2) in cultured human blood mononuclear cells. \nCyclosporin A (CsA) may achieve its immunosuppressive effects by inhibiting the calcium- and calmodulin-dependent phosphat... | [
{
"id": "9428793_T1",
"type": "Protein",
"text": [
"G0/G1 switch gene 2"
],
"offsets": [
[
48,
67
]
],
"normalized": []
},
{
"id": "9428793_T2",
"type": "Protein",
"text": [
"G0S2"
],
"offsets": [
[
69,
... | [
{
"id": "9428793_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibits"
],
"offsets": [
[
14,
22
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9428793_E2"
}
]
},
{
"id... | [
{
"id": "9428793_1",
"entity_ids": [
"9428793_T1",
"9428793_T2"
]
},
{
"id": "9428793_2",
"entity_ids": [
"9428793_T3",
"9428793_T4"
]
},
{
"id": "9428793_3",
"entity_ids": [
"9428793_T6",
"9428793_T7"
]
}
] | [] |
1653056 | 1653056 | [
{
"id": "1653056__text",
"type": "abstract",
"text": [
"NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases. \nNF-kappa B is a DNA-binding regulatory factor able to control transcription o... | [
{
"id": "1653056_T1",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offsets": [
[
25,
52
]
],
"normalized": []
},
{
"id": "1653056_T2",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offsets"... | [] | [
{
"id": "1653056_1",
"entity_ids": [
"1653056_T2",
"1653056_T3"
]
}
] | [] |
2148290 | 2148290 | [
{
"id": "2148290__text",
"type": "abstract",
"text": [
"Lymphoid specific gene expression of the adenovirus early region 3 promoter is mediated by NF-kappa B binding motifs. \nA primary site of infection by human adenoviruses is lymphoid cells. However, analysis of the viral control elements and t... | [
{
"id": "2148290_T1",
"type": "Protein",
"text": [
"chloramphenicol acetyltransferase"
],
"offsets": [
[
1090,
1123
]
],
"normalized": []
}
] | [] | [] | [] |
9731697 | 9731697 | [
{
"id": "9731697__text",
"type": "abstract",
"text": [
"Retinoid X receptor and c-cerbA/thyroid hormone receptor regulate erythroid cell growth and differentiation. \nNuclear receptors are important regulators of erythroid cell development. Here we investigated the impact of retinoid X receptor (R... | [
{
"id": "9731697_T1",
"type": "Protein",
"text": [
"stem cell factor"
],
"offsets": [
[
421,
437
]
],
"normalized": []
}
] | [] | [] | [] |
10425262 | 10425262 | [
{
"id": "10425262__text",
"type": "abstract",
"text": [
"Reactive oxygen intermediate-release of fibre-exposed monocytes increases inflammatory cytokine-mRNA level, protein tyrosine kinase and NF-kappaB activity in co-cultured bronchial epithelial cells (BEAS-2B). \nSome pulmonary diseases like br... | [
{
"id": "10425262_T1",
"type": "Protein",
"text": [
"IL-1beta"
],
"offsets": [
[
1070,
1078
]
],
"normalized": []
},
{
"id": "10425262_T2",
"type": "Protein",
"text": [
"IL-6"
],
"offsets": [
[
1080,
10... | [
{
"id": "10425262_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"elevated"
],
"offsets": [
[
1374,
1382
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10425262_T5"
}
]
},
{
... | [] | [] |
7964516 | 7964516 | [
{
"id": "7964516__text",
"type": "abstract",
"text": [
"Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas. \nT cell hybridomas respond to activation signals by undergoing apoptotic cell death, and this is likely to represent comparable events related ... | [
{
"id": "7964516_T1",
"type": "Protein",
"text": [
"Myc"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "7964516_T2",
"type": "Protein",
"text": [
"Max"
],
"offsets": [
[
15,
18
]
]... | [
{
"id": "7964516_E1",
"type": "Binding",
"trigger": {
"text": [
"binding partner"
],
"offsets": [
[
547,
562
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7964516_T4"
},
{
"role": ... | [] | [] |
1899335 | 1899335 | [
{
"id": "1899335__text",
"type": "abstract",
"text": [
"Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes. \nWe have found that purified human peripheral-blood granulocytes express constitutively significant levels of proto-oncogenes c-jun, jun B and jun D... | [
{
"id": "1899335_T1",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "1899335_T2",
"type": "Protein",
"text": [
"jun B"
],
"offsets": [
[
21,
26
]
... | [
{
"id": "1899335_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"Expression"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "1899335_T2"
}
]
},
{
"id": ... | [] | [] |
10364260 | 10364260 | [
{
"id": "10364260__text",
"type": "abstract",
"text": [
"Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity. \nAlthough many functions of human alveolar macrophages are altered compared with their precursor cell, the blood monocyte (monocyte), the reason(s) fo... | [
{
"id": "10364260_T1",
"type": "Protein",
"text": [
"REF-1"
],
"offsets": [
[
53,
58
]
],
"normalized": []
},
{
"id": "10364260_T2",
"type": "Protein",
"text": [
"REF-1"
],
"offsets": [
[
795,
800
... | [
{
"id": "10364260_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"deficient"
],
"offsets": [
[
40,
49
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "10364260_E2"
}
]
},
{
... | [] | [] |
1953785 | 1953785 | [
{
"id": "1953785__text",
"type": "abstract",
"text": [
"Regulation of interleukin-1 beta production by glucocorticoids in human monocytes: the mechanism of action depends on the activation signal. \nGlucocorticoids are known to downregulate interleukin-1 beta production in monocytic cells by two d... | [
{
"id": "1953785_T1",
"type": "Protein",
"text": [
"interleukin-1 beta"
],
"offsets": [
[
14,
32
]
],
"normalized": []
},
{
"id": "1953785_T2",
"type": "Protein",
"text": [
"interleukin-1 beta"
],
"offsets": [
[
... | [
{
"id": "1953785_E1",
"type": "Regulation",
"trigger": {
"text": [
"Regulation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "1953785_E2"
}
]
},
{
"id": "1953... | [] | [] |
9144479 | 9144479 | [
{
"id": "9144479__text",
"type": "abstract",
"text": [
"CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. \nCD40 is an important signaling and activation Ag found on certain bone marrow-derived cells. Recently, CD40 also has ... | [
{
"id": "9144479_T1",
"type": "Protein",
"text": [
"CD40"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "9144479_T2",
"type": "Protein",
"text": [
"B7"
],
"offsets": [
[
44,
46
]
],
... | [
{
"id": "9144479_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"found"
],
"offsets": [
[
173,
178
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9144479_T3"
}
]
},
{
"id": "9... | [] | [] |
8468462 | 8468462 | [
{
"id": "8468462__text",
"type": "abstract",
"text": [
"Costimulation of peripheral blood T cell activation by human endothelial cells. Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1. \nEndothelial cells (EC) act as APC for resting PBL in vi... | [
{
"id": "8468462_T1",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
89,
93
]
],
"normalized": []
},
{
"id": "8468462_T2",
"type": "Protein",
"text": [
"c-fos"
],
"offsets": [
[
134,
139
]
... | [
{
"id": "8468462_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"Enhanced"
],
"offsets": [
[
80,
88
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "8468462_E2"
}
]
},
{
"id... | [] | [] |
9343210 | 9343210 | [
{
"id": "9343210__text",
"type": "abstract",
"text": [
"Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein. \nRecruitment and extravasation of T cells through the blood-brain barrier are favored by adh... | [
{
"id": "9343210_T1",
"type": "Protein",
"text": [
"vascular cell adhesion molecule-1"
],
"offsets": [
[
34,
67
]
],
"normalized": []
},
{
"id": "9343210_T2",
"type": "Protein",
"text": [
"Tax"
],
"offsets": [
[
... | [
{
"id": "9343210_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"Transcriptional activation"
],
"offsets": [
[
0,
26
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "9343210_T1"
}
]... | [] | [] |
8723387 | 8723387 | [
{
"id": "8723387__text",
"type": "abstract",
"text": [
"Gene transcription through activation of G-protein-coupled chemoattractant receptors. \nReceptors for leukocyte chemoattractants, including chemokines, are traditionally considered to be responsible for the activation of special leukocyte fun... | [
{
"id": "8723387_T1",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
[
851,
860
]
],
"normalized": []
}
] | [] | [] | [] |
8428943 | 8428943 | [
{
"id": "8428943__text",
"type": "abstract",
"text": [
"ras protein activity is essential for T-cell antigen receptor signal transduction. \nIn a Jurkat cell model of T-cell activation an interleukin-2 promoter/reporter gene construct was activated by antigen receptor agonism in combination with t... | [
{
"id": "8428943_T1",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
131,
144
]
],
"normalized": []
}
] | [] | [] | [] |
7545467 | 7545467 | [
{
"id": "7545467__text",
"type": "abstract",
"text": [
"Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. \nNuclear factor of activated T cells (NFAT) was originally described as ... | [
{
"id": "7545467_T1",
"type": "Protein",
"text": [
"granulocyte-macrophage colony-stimulating factor"
],
"offsets": [
[
14,
62
]
],
"normalized": []
},
{
"id": "7545467_T2",
"type": "Protein",
"text": [
"E-selectin"
],
"offs... | [
{
"id": "7545467_E1",
"type": "Regulation",
"trigger": {
"text": [
"Regulation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "7545467_E4"
}
]
},
{
"id": "7545... | [
{
"id": "7545467_1",
"entity_ids": [
"7545467_T3",
"7545467_T4"
]
},
{
"id": "7545467_2",
"entity_ids": [
"7545467_T7",
"7545467_T8"
]
}
] | [] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.