The Overwatch World Cup is returning once again this year to see who is the best of the best in Blizzard's colorful arena shooter game -- and fans are getting more and more excited every day.
Blizzard announced its first World Cup in 2016, and pro players from across the globe came together at last year's BlizzCon to compete against one another. In this inaugural tournament, each national team fought hard to take the championship title, but South Korea walked away with the victory.
This year, with new players and teams in the pro circuit, it can be anyone's game.
We're just getting into the beginning stages of the World Cup, which will culminate at BlizzCon later this year. So there isn't too much information onthe big event yet -- but here's the breakdown on how this year's race for the World Cup is going to take off.
From March through April, players from around the world will test each other in competitive mode on Overwatch. As players continue to play, Blizzard keeps record of top 100 players’ skills online, and uses those scores to average each country’s rank. By the end of April, the first 32 high-ranked countries will be qualified to compete for the World Cup.
After the 32 countries are chosen, each country needs to form an Overwatch World Cup National Committee, which consists of three people in charge of roster picks during the competition matches and the finals. Blizzard asks for 10 expert nominees from each country, and qualified players then vote for whoever they want to choose the roster.
During the summer, eight global teams will go head-to-head at lives event throughout the whole week. But this year, the live stages are not just set in California. Four different live stages will happen across Europe, North America, and Asia. Only the two last standing teams will be moving on to the Overwatch World Cup Finals, which will take place in during BlizzCon 2017 on November 3-4 in Anaheim, California.
What Can Overwatch Fans Do to Support the World Cup?
Regardless of their skill level, fans can participate through Competitive Play. Playing competitive mode can boost a player’s national ranking every time they win a battle. Fans can also support their country by watching scheduled matches online or buying a ticket to see the event.
For more info about the national ranks and where to watch their events, check out the official Ovewatch World Cup website.
Get in there heroes, and play Overwatch!


import React, { Component } from 'react';
import { Meteor } from 'meteor/meteor';
import slug from 'slug';
import Tags from '../../api/Tags/Tags';
import { Creatable as Select } from 'react-select';
import { withTracker } from 'meteor/react-meteor-data';
import { arrayDiff } from '../../modules/utils';

class ChartTags extends Component {

  constructor(props) {
    super(props);
    this.handleSelectChange = this.handleSelectChange.bind(this);
    this.handleNewTag = this.handleNewTag.bind(this);
  }

  handleSelectChange(selectedOptions) {
    const newChartTags = selectedOptions.map(s => s.value),
      oldChartTags = this.props.chartTags.map(s => s.value),
      tagId = arrayDiff(newChartTags, oldChartTags)[0];

    Meteor.call('tags.change', tagId, this.props.chart._id, selectedOptions.map(s => s.label), err => {
      if (err) { console.log(err); }
    });
  }

  handleNewTag(event) {
    const newTag = slug(event.value),
      newChartTags = this.props.chartTags.map(s => s.label);

    newChartTags.push(newTag);

    Meteor.call('tags.create', newTag, this.props.chart._id, newChartTags, err => {
      if (err) { console.log(err); }
    });
  }

  render() {
    return (

Tags

        <div className={`unit-edit ${this.props.expandStatus('ChartTags')}`}>

Add a few tags below

          { !this.props.loading ?
            <Select
              multi={true}
              className={'edit-tags-select'}
              value={this.props.chartTags}
              onChange={this.handleSelectChange}
              options={this.props.availableTags}
              onNewOptionClick={this.handleNewTag}
            /> : null }

    );
  }

}

export default withTracker(props => {
  const subscription = Meteor.subscribe('tags');
  return {
    props,
    loading: !subscription.ready(),
    chartTags: Tags.find({ tagged: props.chart._id }).fetch().map(t => ({ value: t._id, label: t.tagName })),
    availableTags: Tags.find().fetch().map(t => ({ value: t._id, label: t.tagName }))
  };
})(ChartTags);


A Hundred bucks is a small budget for a watch for somebody who used to wear aluxurious and expensive watch. It’s actually not a small budget when you are decided to buy a simple watch that you want to use as your daily driver. You will be in trouble when entering the market. While choosing, you will discover how large the watch market is. There are almost many well-known watch brands watch available on the market and those are the Best Mens Watches Under 100 bucks. Our market research team has to analyse the market since 2009 and we have the overall idea about the cheap watches on the market. There are almost 1,000-20,000 price range watches comparing to these 100 dollars definitely a cheap watch. However, we are here to help you out to choose the best watch for you with this small budget.
Many companiesoffer different types of watches within this budget. You definitely not going to buy a watch that is not comfortable, Stylish, trendy and featureful. Here we will focus on these things before you are going to choose the best watch with this budget.
Design and Style:First of all, the design and style are important. At first impression, you will not look the feature or other things, right? You will look the outfit of the watch. Some watches are round figured with leather belts. Some are square with rubber belts. You can choose anyone according to your taste.
Timekeeping System: The system in important, if you want a classic watch with analogue functionality then you might choose an analogue watch rather than pick up a digital one. However, the digital watches are very popular among the all new generation guys and those have extra features that attract customers easily. In this point, your needs are important to determine the best mens watches under 100. You want a classic watch with theminimalsystem togo for analogue. You like digital watch along with the digital functionality’s then go for digital one.
Features and Functions: The watch you are going to buy must be a great deal. After wearing it, you must feel that was worth of buying and that feeling will come when you have good features and functions on your watch. Water Resistant, Alarm, Calendar, And Timer, Stopwatch, Splits and laps are included in a perfect watch on this budget.
You must be satisfied after reading this guide when you have found the desired watch that you wanted to wear on your wrist. The different company offers various kind of watches and different watches have a different kind of function. We tried to cover the best mens watches under 100 USD and that might be helpful to you. However, the watch you should buy that is your choice and what you actually want depends on you. Our overall idea may come up with your needs. You should look the body function,features and the material that used to build the watch. Hopefully, those things will be helpful to sort the list of your choice with this budget.


How to initialize your HP Envy 4528 Printer?
After you complete all the basic functionalities on your printer, you can install your printer driver setup to your computer. To install the setup you must use the Driver Disc and get it installed in case if your printer driver setup is lost or out dated, you caan download the setup file from 123.hp.com/setup 4528. Install the setup file to your computer and directly access your printer through your computer.


Clinic owner and manager Kathleen Shortt is an experienced physiotherapist whose dedication to life-long learning sees her constantly upgrading her expertise and gaining distinctions in her field.
She graduated from McGill University in 1989 with an Honours Bachelor of Science degree in Physiotherapy, winning the Canadian Physiotherapy Association Award.
Kathleen completed her Advanced Orthopaedic Manual Therapy levels in 1996 and is a Fellow of the Academy of Manipulative Therapy. She has worked in both Quebec and Ontario, beginning her career as a staff physiotherapist at Mount Sinai Hospital where she assessed and treated orthopedic, neurological, medical and sport injury patients.
Prior to starting In Balance Physiotherapy in 2013, Kathleen worked as the Clinic Director of LifeMark Health Physiotherapy On Bay from 2003 until 2012. From 2007 until stepping out on her own to start In Balance Physiotherapy in 2013, she took on the role of Clinical Services Leader for Ontario. As part of this role Kathleen helped develop Clinical Excellence Programs for the LifeMark Ontario Region through developing a Mentorship Program for Ontario. She also ensured an active role in student education at the clinics with their university affiliates.
Kathleen has a special interest in Pelvic Floor Rehabilitation and Vestibular Rehabilitation. She has completed the competency course offered at Emory University in Atlanta, Georgia. Kathleen often speaks at both professional and public conferences on the role of the physiotherapist in these areas.


Ready to trade in your old iPhone so you can buy the latest version of Apple’s flagship? Don’t make the mistake of selling your iPhone to wireless carriers like Verizon, AT&T, Sprint and T-Mobile.
Wouldn’t you rather get more money, fast and in cash?
That’s exactly what we at Flipsy.com are here to help you do. Here are seven reasons you should trade your iPhone in to Flipsy.com instead of your wireless carrier.
Flipsy.com doesn’t buy iPhones. Rather, our free service instantly finds the highest-paying buyers for your iPhone both online and locally for you.
As you can see, trading in your iPhone via Flipsy.com instead of your wireless carrier could net you an extra $100 or more.
Carriers only pay in store credit, typically applied to your monthly bill within one to three billing cycles. You might also be paid via a store gift card; either way, you must spend your payment with your carrier.
That might make sense if you’re in the market for iPhone accessories until you realize you can get the same iPhone cases, screen protectors, and chargers much cheaper online.
Carriers often delay payment. In fact, you could wait up to three months to receive your bill credit for an iPhone trade in.
The vendors featured on Flipsy.com submit payment within one to three days of receiving your iPhone.
Find the best payouts for your iPhone!
Values for previous iPhone models drop between 15 and 40 percent in the weeks preceding a new flagship release, as the market anticipates an influx of used iPhones. Price locks let you sell your iPhone before it loses value, then keep it until you buy the new model.
We’ll show you which buyers offer price locks and for how long (up to 30 days).
If your iPhone has a shattered screen or doesn’t turn on, your carrier probably won’t buy it. However, Flipsy.com finds buyers willing to pay cash for broken iPhones. Even if your carrier will buy broken iPhones, they won’t pay as much as the buyers Flipsy locates.
Private market values: Flipsy.com is the Blue Book of iPhones because it shows how much your iPhone is worth via private sale on Ebay, Craigslist, OfferUp, etc.
Our research tools use real-world data to give you the full picture about your iPhone’s value.
And, since we don’t buy iPhones (and therefore don’t profit from resales), you can trust the service to get you the most money for your iPhone.
Previous: Meet GreenBuyback: Our Newest Trust Verified Store!


Amino-anthraquinone chromophores functionalised with 3-picolyl units: structures, luminescence, DFT and their coordination chemistry with cationic Re(I) di-imine complexes.
The syntheses of four new ligands based upon 3-picolyl functionalised amino anthraquinone (AQ) chromophores are described via a one-pot reductive amination procedure giving the desired ligands L1-L4 (L1, 1-(3-picolylamino)anthracene-9,10-dione; L2, 1-hydroxy-4-(3-picolylamino)anthracene-9,10-dione; L3, 1,4-bis(3-picolylamino)anthracene-9,10-dione; L4, 1,5-bis(3-picolylamino)anthracene-9,10-dione). Each ligand was characterised in solution via(1)H and (13)C{(1)H} NMR, with three examples giving single crystal X-ray diffraction data. The structures confirmed the proposed formulations and also revealed the presence of intramolecular H-bonding between the quinone and secondary amine units. The electronic characteristics of the ligands were investigated using a combined experimental/theoretical approach, revealing that in each case absorption in the visible region constitutes significant charge transfer (CT) character, originating from N-(amine)-to-quinone transitions, and is solvent sensitive. Density functional theory (DFT) calculations also suggest that the position of amino-substitution at the AQ core influences the wavelength of the lowest energy feature, by modulation of the HOMO, rather than the LUMO energy. The coordination chemistry of the ligands was probed through reaction with fac-[Re(CO)(3)(di-imine)(MeCN)](BF(4)) where di-imine = 1,10-phenanthroline (phen) and 2,9-dimethyl-1,10-phenanthroline (dmp). Combined structural and spectroscopic studies confirmed that the ligands coordinate to Re(i) exclusively via the pyridyl units, however in the case of L3 only monometallic complexes were isolated. The optical properties of the complexes are dominated by AQ-centred (>425 nm) absorptions superimposed upon (1)MLCT features, as well as diimine-based intra-ligand (<350 nm) transitions. The luminescence properties of the complexes generally display dual emission, which was dependent upon the wavelength of sensitisation, with short-lived AQ fluorescence superimposed upon long-lived (3)MLCT phosphorescence.


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An elderly woman has stunned doctors by sprouting what looks like a unicorn horn from her head.

The villager has become known to local residents as the 'unicorn woman' since the abnormal growth has appeared and taken over the top of her head.

But although the 13cm-long single large mass is already a massive size, medical professionals are baffled by its apearance.

Liang Xiuzhen, the 87-year-old is a resident of Guiyan village in Ziyang City, in south-west China’s Sichuan Province.

According to Wang Chaojun, Xiuzhen’s son, his mother had something resembling a "black mole" growing on her head seven or eight years ago.

Chaojun said: "My mother complained about this mole-like growth on her head that itched all the time.

"We found ways to cure her itch using traditional Chinese medicine, and then left it be."

(Image: CEN)

Two years ago however, the mole gave way to a small horn-like mass the size of a little finger.

Xiuzhen accidentally "broke" the small horn this February, and in its place her current horn began growing rapidly over the past six months.

Chaojun said: "Now the horn hurts my mother and prevents her from sleeping. It also bleeds from time to time."

Doctors in Sichuan diagnosed the so-called unicorn horn as "cornu cutaneum" (cutaneous horn), a keratinous skin tumour that has the appearance of a horn.

Often small and benign, the growth can in some cases be much larger and malignant.

Chaojun said doctors believe they can remove the growth through surgery, but the family has its reservations due to Xiuzhen’s old age and are considering other options.

"My mother is old, and the horn is on her head which is a very sensitive area. I’m not confident [in the idea of] surgery," he added. "If something goes wrong [during surgery], it would be terrible."


There are two detached luxury villas in a plot of 1400 sq.m approximately and the construction of the two properties was completed beginning of 2006. The architect is Tassos Zeppos well known for his design and construction quality. The two properties provide functionality ergonomics as well as constructional integrity and the aesthetics of the 21^'^ century. It is a superb property with a stunning contemporary interior and wonderful natural light.
House 350 sq.m approximately in three levels (with lift).
Ground floor: Excellent entrance hall, impressive living room with double height ceiling offering stunning open plan living room with swimming pool view, dining room with direct access to a large landscaped private terrace, bespoke hand built kitchen.
First floor: Stylish guest suite creating excellent use of space and light comprising of bedroom with dressing room and ensuite bathroom, private office with garden view and WC.
Lower Ground floor: Natural light, high ceiling, guest studio with bathroom and open plan kitchenette/ bar, laundry room, storage room.
[01 Construction was completed 2006 according to the New Building Law (structural construction for earthquakes, energy control, heating and sound insulation etc).
[02 The architect took the maximum advantage of the plot inclination and the result is that the lower ground floors benefit direct access to the garden.
[04 Large swimming pool, landscaped garden with various lighting scenarios.
[06 Garage 110 sq.m (5- 6 cars).
[08 Built in speakers for music throughout the houses.
[09 Air conditioning for cooling and heating with individual control per room.
[12 Electrical curtains and black out for all windows and balcony doors.
[13 Extra staff apartment can be built in both houses.
[14 The houses are mainly connected by the garage.
[15 Operating room for full voice / data cabling infrastructure.
[16 The lower ground floor offers the flexibility to the purchaser for changes depending on his individual needs for staff accommodation.


Show HN: my first product - a simple cost sharing tool - nclrhombre
http://www.splitacost.com/

======
dwiel
This is great. I've been using essentially this same thing in spreadsheet form
for years in multiple different room-mate situations. Based on our usage
patterns in the spreadsheet version, I would recommend a few changes:

* checking to see who is ahead and who is behind is the operation we used most often. We would check this before we went to buy groceries to see who should pay this week. Same for bills. I know there is the balance tab, but it isn't immediately clear to go there, and I was afraid that when I clicked settle debts that my transactions would/had been cleaned out too.

* shift-tab doesn't go to the previous field when adding transaction

* adding a date field is very helpful for remembering what a transaction was

* in our spreadsheet, my girlfriend and I split most things evenly, but split food 60%/40%. It would be nice, as another poster said if we could at least have some kind of uneven split and so we could set up two pages, one for food and one for everything else. Even better would be to allow choosing that for each transaction, or for a set of transactions, but I understand that may complicate things more than you want to.

* auto-complete on who paid and for what from existing transactions.

* reverse chronological order - if you use this for any amount of time, you want to see the most recent transaction more often than the old ones. May I recommend the new transaction fields go at the top of the page and push older transaction down the page as they are created?

All that said, We probably won't switch since I have a working custom version,
but it has been a system that my room-mates and I swear by, so I hope you can
make it work for other people too.

Thank you!

~~~
nclrhombre
Thanks, this is very useful!

* maybe coloring the names red/green (behind/ahead) would solve this? (hovering the names shows a popup with info on hovered person's balance)

* shift-tab went straight the todo-list

* date fields.. * and uneven splits: yep, in certain situations both could be very useful. Maybe a "more" button that shows extra options like these when recording a Payment/Transfer would be nice.

* auto-complete should actually work already with names. I'll add it to the "for what" field also.

* this splits opinions I think. for me it's more natural to add new stuff to the bottom than to the top. The page scrolls to the bottom when new transaction is recorded, so it shouldn't make a big difference anyhow.

------
bravura
It seems like a useful tool, but it's not a _product_.

(I haven't tried it, but) it looks simple and elegant. However, I can't see
you monetizing it.

Maybe you don't care about monetizing it. If you don't care about monetizing
it, don't call it a product.

~~~
nclrhombre
Actually I'm (probably) going to make a non-free iPhone version of this also.
Therefore this web-version is either a part of a product, or an ad of product.

------
prawn
Not sure if an add-on meant that I missed elements of the front page, but it
was very bland. You could jump people straight to a demonstration with some
presets so they quickly get an idea of what's going on?

As @headsclouds said, shared office expenses are probably a good target for
this and you could look to pursue that opportunity specifically with a domain
alias and tailored copy pretty easily.

I am in a shared office situation and have expenses that would be perfect to
track using this, but it would all have to be crystal clear for me to bother
switching from just writing notes on paper (and losing them).

Can't think of a strong way you could monetise this so it might be best to
keep it clean and ad free, then have it "Presented by (some company/service
relevant to small business types)", whether that's a single sponsor or another
business/service of yours.

Edit: Added another participant and noticed the colour-coded data when you
mouse over their names. Make it a bit clearer that you can mouseover for that
info - maybe a magnifying glass icon.

Maybe you could have 3-5 read-only demo sheets - friends on a trip, shared
office situation, someone needing to be paid back for buying the game tickets
(I could use it for this right now too), people chipping in for a joint
wedding gift, etc.

~~~
nclrhombre
Probably not missing anything, the front page is text only (+button)
currently. And yes, there's definitely room to improve it..

I actually never even thought of the shared office targeting before. It seems
I should, it does sound like an opportunity for the concept.

------
apitaru
Great job, it's a simple no BS calculator that does exactly what it sais it
does. And good call not asking for registration, and going the way of a
sharable url instead. I'll be using this. Thanks!

update: I can imagine wanting an account that organizes my urls. It would be
cool that have that button on the side, but not push for people to register.

~~~
nclrhombre
Thanks! Yep, that could be nice feature. I've found myself bookmarking those
events in a dedicated folder, but that's not very handy.

------
ideaoverload
I like it too. Neat idea for free service... Any ideas on monetizing it?

Small suggestion : Expenses/Balance links are not immediately visible. I was
looking for them at the bottom of the page. edit: better description

~~~
nclrhombre
Thanks for feedback, I'll have think about the navigation.

Yeap, the monetizing plan is to make a non-free IPhone version that works
seamlessly with the web-version. Hopefully the web-version will help to boost
the marketing of the IPhone-version.

------
headsclouds
This would be super useful to us if we could set percentages of the total
amount everyone is due.

We share an office with a couple other companies, but the lease is at our
company's name, and we always pay for everything and people pay us back.

Since some companies are three people, and some folks here are freelancers
they aren't all due the same amount; i.e. there is 10 of us, but my company
pays for 2/10 because there's two of us using the office.

Maybe adding this feature would open up your service to more users with our
problem users. (We are using a shared Google spreadsheet.)

~~~
guruz
Jup, but not only percentages but also absolute values.

Was just with my room mate at IKEA. I used my card to pay. Some stuff is for
the whole appartment, some stuff only for me, some stuff only for him.

~~~
aparadja
Doesn't the app already do that (not the percentages, but the "some for me,
some for only him" thing)? The last option of each expense is to pick who
should pay for it.

------
lpolovets
Nice site. A little bit of feedback:

\- Once you click on "Settle Debts", it's not clear how to get back to the
list of expenses.

\- I like that you auto-create debts and participants from entries. The
downside is that if I make a typo in someone's name, there doesn't seem to be
a way to delete that person, even if I delete the transaction w/the typo.

\- I mindlessly entered $10000 into the expense field, and it was
automatically changed to $9999.99. What's the reason for the $10k cap?

~~~
nclrhombre
Thanks for feedback!

\- Yep, the navigation is a bit asymmetric now. I think I'll add more focus to
the navigation bar, and maybe even remove the "Settle Debts"-button.

\- Actually there is a way. After you have deleted the last transaction of a
person, a small "x" button appears next to that person's name in the
participants-list. A bit unintuitive maybe.

\- Actually, there are no good reasons for the cap. The best is probably to
avoid long rows, but 10k is a bit low for that. I'll raise the cap or remove
it completely.

------
rgarcia
A lot of people are looking to solve the expense-sharing problem...nothing
seems to have caught on, though. Off the top of my head:

<http://www.venmo.com> (has payments)

<http://www.billmonk.com> (the very first)

<http://www.splitterbug.com> (now defunct)

~~~
nclrhombre
I hope that not requiring registration lifts SplitaCost above these.

~~~
gcl
It's fun to hope but have you gathered any data that suggests that people are
frustrated with having to create accounts for bill-sharing apps?

If you built this to further your own education/skills, great job. If you
built this to turn into a product, do your research first or else a lot of
your talent/effort/time will be wasted.

~~~
nclrhombre
No thorough analysis done, just some hours with Google and observations of the
way people I know deal with expense sharing (excel/paper).

The problem is real tough: calculating this stuff by hand is painful. And
because people still do that, it could be solved better than it already is.
Choice between free, easy to use tool and paper is a no brainer (if you know
that the tool exists, that is)

\--> No signup, because it makes it more likely that you know about the tool.
(easier to start using, and a lot more likely to spread)

How many people can I spread this to then? I have no idea, but I think this is
the fastest way to find out. If it spreads, awesome, and if it doesn't, I'll
just swap to some other project. Not much lost here.

(And yes, education is also a big motivator. This is my first tool after all.
I still see some value in just shipping tools _some_ people will actually use,
profitable or not. A simple, fast project is good for this.)

------
jontas
Recurring expenses would be useful. For example, my roommate and I pay rent
every month and the amount never changes. I should be able to enter this just
once.

Also, some sort of payment integration (PayPal, etc.) would be nice so he can
come to this page, see he owes money, pay it and have that payment recorded.

Excellent product though, I could see myself using this.

------
parfe
I got lost once I clicked settle debts. There was no visual cue that Expenses
were accessed through the menubar at the top of the page. Once I hit "Record
Transfer" I was left looking at the debt page with no where to go.

~~~
nclrhombre
I'll change the menubar to be a bit more flashy (there is a subtle color
difference between the selected page and the rest of the menubar. A bit too
subtle, it seems)

------
thetable
Wow, it's really similar to a tool I've been working on:
<http://grouppay.backin.de>

Glad to see you share the vision (no signup, just go straight to a unique
link).

~~~
nclrhombre
Wow, you've managed to simplify the concept even more! I guess the lack of
money transfers limits this to non-continuous cases tough. (Which might be
just fine)

I like the fact that the "landing page" is the tool, hopefully this stays with
the finished version also.

This could be just due to the unfinished status, but currently at least it
does require awful lot of clicking around with mouse. At least entering the
cost of an item right after the name should be possible without touching the
mouse. (and it actually took a moment for the first time to notice that you
can edit the cost afterwards)

Maybe it would be also good to make a more drastic graphical difference
between the names and the items?

Are you planning on adding possibility to mark certain items to be paid by
certain people only?

~~~
thetable
Yeah, I think in the finished version, you would always start automatically at
a unique URL, and the app would auto-save.

I agree that full keyboard control would be nice. At the very least, you
should be able to tab through fields.

Also, not every user understood the distinction between users and expense
items, so you're right about that.

Marking items only for certain people: Hadn't planned to do it in the first
version because I didn't know what the interaction would look like, but I like
your solution. Also, without this feature, everything works as one page (no
need to have a separate page for settling debts).

------
jjchiw
I like that I don't need to "register" or login/password.......I don't know
how this will work with the mobile app you're working on, maybe register the
"pages" in the app....anyway

Good work....+1 - Like

~~~
nclrhombre
Thanks!

Yes, current (early) plan of the mobile version is to store the addresses
(+names) of the used Events on the phone. (actually, the Payments/Transfers
will probably be also saved in the mobile device, to allow offline use)

Accessing Events created with the web-version for the first time with the
mobile app is bit of open question tough. Copypasting the URL is maybe not the
user friendliest way to handle this. Creating a user account of some sort for
the mobile users might be a better idea..

------
nodata
Can you add a feature? I'd like to take a picture of a restaurant bill, have
it automatically OCRed, and share the bill with other people's phones. Each
person decides which part of the bill they pay.

~~~
nclrhombre
Sounds cool alright, but the actual value added is maybe not that big.
Everyone should still manually enter data, so just entering the data manually
while looking at the bill could actually be faster..

This probably is not the easiest thing to implement either..

~~~
nodata
Perhaps, but it's something tons of people would use, and it's the difference
between people using your tool or not imo.

------
talkingquickly
Did this come out of startup weekend London? There were a couple of teams with
similar ideas there and would be great if this was another team who stayed in
touch and carried on after the event.

~~~
nclrhombre
Nope, not from London.

------
molsongolden
The app doesn't seem to be loading!

~~~
nclrhombre
the blue spinner never vanishes? Did reload help?

------
michaelvillar
seems very useful. I can't enter numbers in the "how much" field though.
(Safari, Mac OS X)

~~~
nclrhombre
hmm.. strange, works well on my Mac+Safari combination. Wich version of
Safari/OS X are you running it with?

~~~
bockris
The number pad doesn't work for me but the keyboard numbers do. I started to
debug but was scared off by seeing all the gwt-* class names. ;-)

WinXP Chrome 16.something (dev channel)

~~~
nclrhombre
Oh, this is enough info to fix it, I think. Thanks. Numpad probably sends
different keyCodes than keyboard numbers, and the (hacky) number field doesn't
consider them numbers at all. I'll look into this soon.

------
endtime
Why is this better than Billmonk?

~~~
nclrhombre
You need to register to Billmonk, not to SplitaCost

~~~
endtime
Okay, not convinced that's really a benefit (registration lets Billmonk be
more useful), but even if it is, what if I'm already registered with Billmonk?

~~~
nclrhombre
Then you should probably stick with Billmonk. You're correct, "no signup" is
mainly a benefit for those who are not already registered to some competing
service, but then again, most people don't use Billmonk.


MONTREAL – Andres Romero and Jack McInerney scored in the Montreal Impact’s 2-0 victory over the New England Revolution last night.

Romero scored in the third minute, and McInerney in the 38th.

Montreal (2-6-4) ended New England’s winning streak at five and its unbeaten run at seven, dropping the Revolution to 7-4-2.

Romero took a long through ball from striker Marco Di Vaio and moved in all alone on goalkeeper Bobby Shuttleworth. With Revolution defenders requesting an offside call on the play, Romero held onto the ball several seconds before beating Shuttleworth between the legs for his career-high third goal.

Later, Nakajima-Farran cut into the middle and fired a powerful strike at Shuttleworth. The keeper bobbled the ball before striker McInerney pounced on the rebound from just outside the 6-yard box.


HIGH-TECH PLATTER. Du Pont Co. and N.V. Philips of the Netherlands say they plan a joint venture to become the world's largest supplier of optical disks, the high-tech platters that are making a leap from music to data storage. Optical storage is still in its infancy and is mainly used to make compact disks of digitally recorded music. As an example of the disks' capacity, Du Pont and Philips said a single 14-inch-wide, high-density optical disk could hold the unabridged dictionaries of every language in the world.


At Drip Irrigation System Guys, we have a rich pool of well trained, experienced and adept experts who will help procure the best irrigation system. There are various issues that concern the drip irrigation system. For instance, there is need for low-pressure and low volume water system that delivers the water to various plantations such as trees, flowers and foliage cover. Such water system has to be designed in a way that there is minimized water wastage. Only trained and experienced technicians will be able to deliver you such kind of high quality and efficient drip irrigation system. Engage us at Drip Irrigation System Guys in Hardesty, OK so that our experts will assist you get the most out of your investment in drip irrigation system.
You can received fully insured, bonded and licensed services in Hardesty, OK thanks in the part for the fact that we take legality in our undertakings very seriously. There are issues such as the need to get cover for the services so that even our clients can be compensated in case they there is fault on our end in regard to the installation of the drip irrigation system. A poorly installed drip irrigation system could be recipe for environmental disaster. The water will be wasted and end up as run off which will ruin our environment. The health of your plantation such as trees and flowers in your lawn gardens could also be jeopardized due to excess moisture in the soils. It is therefore important that the whole aspect of procurement, installation and maintenance be carried out by certified personnel. You will be in good books with environmentalists if you strictly adhere to safe and sound environmental systems by conserving water and preventing surface run off. We rank equally with other industry players in Hardesty, OK in such a way that you will get the confidence to approach us for further guidance and support.
From the Drip Irrigation System Guys in Hardesty, OK, you will come to rely on the efficiency, quality and standard of services that we offer our clients. With years of experience in the installation and maintenance of Drip Irrigation Systems, we have earned a high level of reliability. We undertake to deliver o our promises without fail. As a result, we have cultivated a culture of trust from our customers such that we implement every need that arises without failing. Talk to us on 800-373-1660 and learn more about our various services.


As a candidate, Donald Trump vowed that if elected he would use his business talents to make the best deals for the American people. But as president, Trump’s first foray into dealmaking failed miserably with the demise last week of the Republican plan to repeal and replace Obamacare.
What went wrong? Real estate deals and legislative deals are quite different — and Trump’s business experience is ill-suited for work with Congress. Here’s why.
What is the ‘art of the deal’?
Trump’s book “The Art of the Deal” deals with business negotiations, in which the basic protocol involves alternating offers between negotiating partners. When you want to buy something, you make an offer below the asking price. Then the seller makes a counteroffer, and so on until the two offers converge.
In this process, one of the two parties may say the following. “This is my final offer. Take it or leave it.” If the other party considers the statement credible, she makes the agreement with the terms offered. If not deemed credible, the parties continue to bargain, and the game continues (while the first player has lost his credibility).
In legislative bargaining, alternating offers are not part of the protocol. Nor do outside options exist. Indeed, despite news media suggestions that the president sets the legislative agenda with the State of the Union address, Congress sets its legislative agenda.
If a bill does not pass in Congress, the legislature can take up the initiative again, if it wishes to do so. And the president will most often wait until a bill clearing both chambers reaches his desk before he can sign or veto it. The president cannot directly intervene in the negotiations; whether the legislature is controlled by his party or the other party, he can act only behind the scenes.
Consequently, it makes no sense to say to the other players, “This is your last chance. Take it or leave it.” As a result, if you are the president and you make this statement, you’re not credible. More accurately, you cannot possibly be credible because you do not directly control the agenda.
Think about an alternative outcome on Obamacare repeal, in which House Speaker Paul D. Ryan (R-Wis.) comes back in a month or a year with a new proposal that can pass both chambers. Would anybody expect the president to veto it? If not, what is the meaning of the “take it or leave it” statement?
Further, “outside options” don’t exist in a legislature. The president cannot have several balls in the air. He does not have an alternative Congress. And alternative bills can be formally initiated only by Congress, not the president.
Granted, the president and legislative leaders may negotiate, behind the scenes, about their priorities. And Republicans (at both ends of Pennsylvania Avenue) surely discussed the order in which to introduce items on the agenda, like taxes, the wall, immigration, Obamacare and the environment. Such discussions probably concluded that Obamacare should go first, considering the more than 60 times the Republican House had voted to repeal the Affordable Care Act while Barack Obama was president. The GOP bill’s failure means that Republicans will soon turn to the next item on their agenda.
Trump’s attempt to transpose his business experience directly to politics did not fare well. This is to be expected, because the games are different. You cannot play basketball with a tennis strategy. There’s a reason the games of politics and policy are played by professional politicians. Newcomers have a steep learning curve, as the president is discovering.
George Tsebelis is Anatol Rapoport Collegiate Professor of Political Science at the University of Michigan, Kellogg Institute Guest Scholar, and author of Veto Players: How Political Institutions Work (Princeton University Press, 2002).


Copyright Flipped On Its Head: A Creators Perspective | hypebot
Neil Turkewitz challenges some of the common narratives that have recently been spread regarding copyright, including the idea that copyright limits freedom of expression for artists, and works to the advantage of the already rich and powerful.
Guest post by Neil Turkewitz from Medium
Over the course of the past few weeks, I have noticed what seems to be an escalating narrative on social media portraying copyright as the province of the rich and powerful, and intimating that artists will be liberated once freed from the shackles of property. Of course, this has been a theme playing in the background and in large swathes of academia for a long time, but it seems to be seeping into more public discourse of late given battles over copyright in EU and globally, and the massive amount of disinformation being conveyed by YouTube and others in an attempt to preserve the status quo under which they pay little or nothing for the principal resource that they monetize and upon which their fortunes have been made. Given that well-meaning people, both progressives who support the arts and focus on human dignity, and conservatives who would generally understand the importance of property as a foundation of liberty, have been sucked into this vortex of confusion, I thought it might be useful to briefly, and soberly, examine the realities of copyright.
MYTH: Copyright Limits Freedom of Expression
Copyright is the protection of expression. At a minimum, the fact that copyright protects original expression and sustains those that express it should give pause to anyone that hears that it is a form of restriction on expression. But let’s dig a little deeper. Copyright does not protect ideas — in fact, it operates as an incentive to share ideas in public fora without losing the ability to determine the uses of the author’s particular form of expression. This is known as the idea/expression dichotomy. In some instances, even expression will not be protected — for example where the idea which is shared is really incapable of being expressed other than as expressed by the author. This is known as merger doctrine. There is also a doctrine similar to merger, drawn from French law, known as “scènes à faire” which limits the application of copyright protection to expression which is a necessary part of expressing the idea.
And of course, copyright does not extend to facts — an important distinction to bear in mind next time that you hear that copyright is somehow interfering with information.
MYTH: Copyright Only Serves the Interests of the Rich and Powerful
Rich and powerful companies certainly benefit from copyright, and many of the most valuable copyrights are held by corporations. But companies and organizations that campaign for weaker copyright (or the status quo lack of platform accountability) want you to believe that Mickey Mouse and Disney are the only things you should think about when considering copyright. This must be rejected (side note: the incentives provided by copyright have allowed companies like Disney to invest in the production of films and other materials which have entertained and thrilled us, so I actually think the focus on Disney is wildly misplaced, but that’s for another day). The fact that copyrights may sometimes serve the interests of corporations must not obscure the fact that copyright at its core is about the right of the individual to determine the uses of her work — the right to say yes or no to the most powerful interests in the world. Effective copyright protection serves the interests of all creators — from those that want to negotiate a deal with a corporate entity that will pay for, publish, produce, and distribute that work for the market, to DIY artists that want artistic and financial control, to those artists that want to give away their works, to anyone in between.
At a critical philosophical level, copyright is a recognition of the importance of consent in a world rushing towards models of efficient monetization that would erode the ability of the individual to make decisions for herself. It rewards the singular by standing in the way of a dehumanizing Singularity. And if we can create an environment in which it doesn’t take an army to enforce it, copyright expands the choices available to creators about how to determine the contours of their careers.
MYTH: Copyright Defends Legacy Business Practices Against Innovation/Competition
This is a powerful one and oft-cited. But ridiculous. Copyright provides creators with a bundle of rights that may be exercised in a way that is tech neutral. In no way does it protect any particular business practice or model. It is both flexible and adaptable. I implore you dear reader, please pay close attention to the arguments of any party that invokes any form of this myth. They are trying to mislead through this time-tested imagery. Copyright is not about the past — -unless we fail to keep it vibrant and robust, in which case we will all lose. The irony of all ironies is that it is tech companies desperately clinging to internet rules adopted at the dawn of the commercial internet to preserve their legacy practices which permit the acquisition of their principal resource without meaningful negotiations (or wholly without negotiating). Their “future” is rooted in the past and would lead to a culturally bleak landscape. As for competition, copyright only provides that creators are not forced to compete against themselves. They are in a constant struggle to compete for attention and compensation with other creators. They shouldn’t have the additional burden of competing against unauthorized uses of their own creations.
MYTH: The Name of the Game is Promotion
Well, that’s true if you’re in the business of promotion. Not so true for artists trying to sustain themselves through licensing of their works. This myth starts with a grain of truth — promotion/visibility is an important component for any artist. Being unknown makes it hard to compete in a very competitive environment. But because promotion is a feature of artists’ careers must not serve as an invitation to take away the ability to determine for themselves how to engage in promotion. Copyright is not an impediment to promotion, and undermining it (copyright) is not a form of artist-liberation from an unjust ecosystem. This particular myth may be the most frequent and poorly considered — that because artists are sometimes exploited by companies with whom they do business, we are somehow helping artists by eroding copyright. Copyright is not the means by which artists are constrained — it is their only leverage. Eroding the value of copyright further undermines the position of individual creators. To those of you that want to empower creators — give them asset that has more value. A property interest that can be easily enforced by an individual against ANY company or platform. When creators need armies, they will always be at mercy of said armies. Free them. Support copyright reform that brings copyright into the digital age by addressing the limitations of existing rules that have manifested themselves in the 20 years or so since the adoption of first generation rules of internet governance.
Finally, for further myth-busting, please see this excellent piece by John Degen, Executive Director of The Writers’ Union of Canada, and self-proclaimed “believer in the future of the book” entitled: “5 Seriously Dumb Myths About Copyright the Media Should Stop Repeating.”
[from https://ift.tt/1n4oGj7]


10 People Who Undergone Plastic Surgery To Look Like Their Favorite Celebrity – 3Stoogiez!
We always idolize our favorite celebrity and see them as a fashion icon. We always put our best effort to look like them like copying the haircut, fingernails, gesture and a lot more but there are individuals who are ready to cross the line in order get the exact copy of their favorite celebrities.
One of the best method and very popular these days is plastic surgery. With our current technology, anything is possible as long as you have money. All you need to do is to find a good doctor otherwise you will end with some weird looks like what we have seen in the news.
Below is the compilation of individuals who undergone multiple times of surgery in order to look like a specific celebrity. Tell us what you think about them and comment it below.
What happened to Toby Sheldon is the result of “Bieber Fever”. Toby is 14 yrs older than Justin but he still manages to copy the looks of the famous Canadian pop star after spending $100, 000.


We have been supporting less fortunate children in Colombia since our inception.
Our number #1 mission is to fund building schools for the indigenous children of the Kuna and Wayuu cultures.
A portion of our proceeds are donated to provide basketball equipment to these children in the poor sections of Colombia.
We provide clothing and toys for poor children in the poor areas of Bogota Colombia.
For me….. This is the best thank you card I could ever have in my life. These beautiful pictures especially this one with the stuff I collected from my kids and my friends.


How To Use Twitter Hashtags Inside Your eBook

Last month we gave you a sneak peek at the enhanced eBook edition of Here on Earth: A Natural History of the Planet by Tim Flannery–a digital book that incorporates Twitter conversations into the app. Today, the book is on sale in the Apple App Store.

As you can see by the image embedded above (click to enlarge), the new eBook allows readers to take notes, copy text, and join Twitter conversations without ever leaving the digital text. Any Twitter reader can discuss the book at the #HereOnEarth hashtag, and the enhanced eBook will collect those conversations.

What do you think–are you ready to join Twitter conversations inside your eBook? We caught up with Arcade Sunshine Media president Aziz Isham to find out more about the app and how other writers can use these new tools.

Q: Can you talk about your note-taking and Twitter functions inside the eBook app–what can readers do with these features?

A: We’re lifelong readers – and one of the most common complaints we’ve heard about ebooks was that it’s impossible to mark-up a digital book. Our solution, which is a little different from most of the other readers out there, allows you to send passages from the book into an embedded notepad, add your own comments, and store it inside the book. When you’re done, you can simply email the whole file to yourself. If nothing else, it should make writing a term paper a whole lot easier.

As for Twitter, one of the joys of reading is engaging in a conversation with other readers about the book. By incorporating a pre-populated twitter feed into the book, that conversation actually becomes part of the book itself. It’s kind of like having an instant book club inside of your book.

Q: Your company also offers services for individual writers. In the most practical terms, what could you offer to a hypothetical unemployed journalist (with a very limited budget) who has been reporting, blogging and recording multimedia material about the Brooklyn music scene?

A: Here’s a really good example of how multimedia publishing can be profitable for everyone involved. We have an awesome partnership with a company called Element 84 – these are the guys who make apps for NASA – and one of the first things that we set out to do was make sure that our platforms can be extremely versatile.

So if this unemployed journalist has a decent mailing list, a ton of great media, and can write well, and we think he or she can sell a thousand apps, then all of a sudden the numbers aren’t looking so bad after all. And if before it would cost them $50,000 or more to create a multimedia app, we’ve been able to bring that number down to a level that even an unemployed journalist can manage.

Q: Some publishers worry that apps are too expensive and don’t sell enough copies. What do you say to critics of enhanced eBooks?

A: Those publishers are probably right. Honestly speaking, I doubt that we break even on this project – and a lot of favors were called in order to make the Here on Earth app a reality. But I’m not convinced that compensation is the main reason why we create.

Sometimes, we do it just to see what’s out there, to experiment a little and to try new things. I used to make reality television, and I might do it again in the future, and I wouldn’t dream of doing that for free. But the printed page will become digital – that’s inevitable – and when it does, the message that it contains will be changed by the digital medium.

The Here on Earth app isn’t the beginning of this transformation, and it certainly isn’t the end of it, but if it’s a footnote along the way, then we’ll be happy. Of course, you can’t eat happiness, so we’ll also continue experimenting with ways that digital publishing and enhanced eBooks can be profitable – personally, I think that there’s a whole word of narratives that will emerge to take advantage of these new mediums, and I think that there will be customers for these new narratives.

Storytelling is a pretty awesome and pretty ancient art – and I’m pretty sure that it predates capitalism. So I think it’s up to the market to adapt to new forms of storytelling, and not the other way around.

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Phil Jackson set to return?

Amick: Would be surprised if Jackson's not back in NBA

http://archive.thetowntalk.com/VideoNetwork/3286165997001/Phil-Jackson-set-to-return-rtmp://cp17277.edgefcs.net/ondemand/&mp4:Brightcove/Brightcove2/29906170001/2014/03/29906170001_3283971021001_Thoughts-from-Phil-Jackson.mp4http://archive.thetowntalk.com/VideoNetwork/3286165997001/Phil-Jackson-set-to-return-http://videos.usatoday.net/Brightcove2/29906170001/2014/03/29906170001_3285741906001_thumbnail-for-video-3283461298001.jpgPhil Jackson set to return?Amick: Would be surprised if Jackson's not back in NBA5basketballSMGVnbasportsUSA Today Sportsvideo big board01:33


Staff Director, PTC and S&TC, Office of Safety, FRA
Railway Engineering
The Federal Railroad Administration (FRA) is looking for an experienced railroad signaling professional to serve as the Staff Director for Positive Train Control (PTC) and Signal & Train Control (S&TC) Division in the Office of Railroad Safety. The Staff Director for PTC/S&TC is the principal program advisor in the Office of Railroad Safety on all new and existing signaling, train control and PTC technologies and their associated safety and security issues. The incumbent is a leader in the industry and is able to manage a large, disperse team to deliver complex rail safety programs. For more information regarding this position and how to apply go to: https://www.usajobs.gov/GetJob/ViewDetails/538605800
Internal Number: FRA.S-2019-0026
About Federal Railroad Administration
The Federal Railroad Administration (FRA) is responsible for ensuring the safety of the Nation's passenger and freight rail operations and infrastructure by promoting safe, efficient and accessible rail transportation. The mission and focus of FRA has grown to include the design and management of an unprecedented investment in the creation of a nationwide passenger rail network. FRA is providing leadership for the creation of a more balanced transportation system, transforming the way Americans travel.To meet this mission FRA promulgates and enforces rail safety regulations; consolidates government support of rail transportation activities; administers financial assistance programs; conducts research and development in support of improved railroad safety and efficiency, and national transportation policy, including improved intercity passenger service.FRA is committed to fostering a diverse, highly skilled workforce capable of meeting or exceeding our strategic goals with efficiency, innovation, and a constant focus on better serving our customers. The FRA is ranked by its employees as one of the top-rated agencies in which to work.
Manager, Rail Transportation Communications San Carlos, California
San Mateo County Transit District 1 Month Ago


Wish you could avoid airport queues, tedious transfers and long drives?
Want to travel enjoyably by train instead - to fantastic accommodation in the best ski resorts in the Alps?Snowcarbon is an independent information site set up by ski journalist Daniel Elkan to help you do exactly that.

The Eurostar Ski Train experience

Snowcarbon's new film about the Eurostar Ski Train experience - as told by skiers and boarders.

Le Paris Stopover to the Alps

A party of 24 friends travel via Paris to the Alps - arriving in resort early enough to ski the same day

A quick guide to Snowcarbon

Welcome to Snowcarbon! Here's a quick guide to how we can help you make the journey part of the ski holiday.

In the resorts and journey planner section, you can view recommended journey schedules for travel from the UK to 32 great ski resorts in the Alps, using our unique Journey Planner, based on a unique database of hand-researched journeys. Every single train ride in the journey planner we've travelled on, photographed, and described for you. And you can also read reviews of these journeys by other skiers on the Your Stories section - and contribute your own.

For each ski resort you can see in independent, multi section resort review written by our leading ski writers. And for each resort we'll show you the best options for booking independent travel and rail-inclusive ski packages where available too. You can also ask Snowcarbon co-founder Daniel for recommendations on great resorts, lovely journeys and fantastic accommodation providers to help create your ideal ski holiday. Just email Daniel and he'll be happy to help.

The rail-inclusive ski packages section is a unique resource for finding ski holidays from a variety of ski tour operators with rail travel (and transfers) included - which make them easy to book - and good value.

We'd love to know what you think of the site, and any ways you think we could improve it. So please feel free to drop us a line with your thoughts or questions.


Everything you need to make a kite. We stock a wide variety of spare parts and accessories for kite making projects and repairs..
Discounts: Quantities greater than ten times the pack quantity will typically receive a discount of 10%. The discounted price will be shown in your basket if you enter the higher quantity.


Organisations can rarely if ever solve their health and safety problems by simply introducing 'one off' measures following accidents. This reactive approach fails to investigate why accidents were not prevented in the first place and does not address underlying weaknesses which, if not remedied, will sooner or later give rise to further accidents.
Plan: Produce a policy or plan for managing occupational road risk, describing the procedures, people and resources that will be used, the risks which have been identified and control measures that will be implemented. This should cover the journeys, drivers and vehicles that are used by the organisation, and clearly set out everyone's roles and responsibilities for work-related road safety. The policy or plan should be clear communicated to drivers, riders and managers.
Do: Implement the policy or plan, prioritising and control risks, consulting staff and providing the necessary resources, information, advice and training. Use or set up adequate systems to manage work-related road safety, and record that it is being implemented (for example, driving licence checks, vehicles inspections, drivers hours, driver training, etc. Involve staff or their representatives in decisions, and provide training and instruction where necessary.
Check: Monitor performance to ensure your work-related road safety policy is being implemented and is effective. Encourage staff to report all work-related road incidents or near misses, and to pro-actively raise any concerns they have. Ensure accidents are investigated, immediate and root causes, and that les-sons learned and shared throughout the organisation.
Act: Review the organisation's performance against targets, auditing health and safety management processes and feeding back information and experience to further develop policies and improve performance.


Retrieve "everything" in a particular group by leaving the search box empty.

Search for an exact phrase or a list of terms.Note that the spelling of what you enter into the search criteria box affects the results; for example the singular forms may give you different, broader results than the plural.

Search a group of records associated with a specific Researcher by selecting from a dropdown. Note that some publications of many authors who are no longer with the Institute, and consequently are not listed on the dropdown selection list, may be found by entering the name with an initial separeted by a space and checking off the "Search Only for Exact Phrase" checkbox.

Additional controls are located at the bottom of the results window. Use them to scroll through the pages, skip to a specific page, choose how many items are displayed per page, and toggle between a list view and a table view of the results.

Polycystic kidney diseases (PKDs) are inherited disorders characterized by the formation of fluid filled renal cysts. Elevated cAMP levels in PKDs stimulate progressive cyst enlargement involving cell proliferation and transepithelial fluid secretion often leading to end-stage renal disease. The glycogen synthase kinase-3 (GSK3) family of protein kinases consists of GSK3alpha and GSK3beta isoforms and has a crucial role in multiple cellular signaling pathways. We previously found that GSK3beta, a regulator of cell proliferation, is also crucial for cAMP generation and vasopressin-mediated urine concentration by the kidneys. However, the role of GSK3beta in the pathogenesis of PKDs is not known. Here we found that GSK3beta expression and activity were markedly upregulated and associated with cyst-lining epithelia in the kidneys of mice and humans with PKD. Renal collecting duct-specific gene knockout of GSK3beta or pharmacological inhibition of GSK3 effectively slowed down the progression of PKD in mouse models of autosomal recessive or autosomal dominant PKD. GSK3 inactivation inhibited cAMP generation and cell proliferation resulting in reduced cyst expansion, improved renal function, and extended life span. GSK3beta inhibition also reduced pERK, c-Myc, and cyclin-D1, known mitogens in proliferation of cystic epithelial cells. Thus, GSK3beta has a novel functional role in PKD pathophysiology, and its inhibition may be therapeutically useful to slow down cyst expansion and progression of PKD.Kidney International advance online publication, 28 January 2015; doi:10.1038/ki.2014.427.

In mammals, glycogen synthase kinase 3 (GSK3) comprises GSK3alpha and GSK3beta isoforms. GSK3beta has been shown to play a role in the ability of kidneys to concentrate urine by regulating vasopressin -mediated water permeability of collecting ducts, while the role of GSK3alpha has yet to be discerned. To investigate the role of GSK3alpha in urine concentration, we compared GSK3alpha knockout mice (GSK3alphaKO) with wild type (WT) littermates. Under normal conditions the GSK3alphaKO mice had higher water intake and urine output. The GSK3alphaKO mice also showed reduced urine osmolality and aquaporin-2 levels, but higher urinary vasopressin. When water deprived, they failed to concentrate their urine to the same level as WT littermates. Addition of 1-desamino-8--arginine vasopressin (dDAVP) to isolated IMCD increased the cAMP response in WT mice, but this response was reduced in GSK3alphaKO mice, suggesting reduced responsiveness to vasopressin. Gene silencing of GSK3alpha in mpkCCD cells also reduced forskolin-induced aquaporin-2 expression. When treated with LiCl, an isoform non-selective inhibitor of GSK3, and known inducer of polyuria, WT mice developed significant polyuria within 6 days. However, in the GSK3alphaKO mice, the polyuric response was markedly reduced. These studies demonstrate for the first time that GSK3alpha could play a crucial role in renal urine concentration and suggest that GSK3alpha might be one of the initial targets of Li+ in LiCl -induced nephrogenic diabetes insipidus.

Glycogen synthase kinase-3 (GSK-3) is one of the few signaling molecules that regulate a truly astonishing number of critical intracellular signaling pathways. It has been implicated in several diseases including heart failure, bipolar disorder, diabetes mellitus, Alzheimer disease, aging, inflammation, and cancer. Furthermore, a recent clinical trial has validated the feasibility of targeting GSK-3 with small molecule inhibitors for human diseases. In the current review, we will focus on its expanding role in the heart, concentrating primarily on recent studies that have used cardiomyocyte- and fibroblast-specific conditional gene deletion in mouse models. We will highlight the role of the GSK-3 isoforms in various pathological conditions including myocardial aging, ischemic injury, myocardial fibrosis, and cardiomyocyte proliferation. We will discuss our recent findings that deletion of GSK-3alpha specifically in cardiomyocytes attenuates ventricular remodeling and cardiac dysfunction after myocardial infarction by limiting scar expansion and promoting cardiomyocyte proliferation. The recent emergence of GSK-3beta as a regulator of myocardial fibrosis will also be discussed. We will review our recent findings that specific deletion of GSK-3beta in cardiac fibroblasts leads to fibrogenesis, left ventricular dysfunction, and excessive scarring in the ischemic heart. Finally, we will examine the underlying mechanisms that drive the aberrant myocardial fibrosis in the models in which GSK-3beta is specifically deleted in cardiac fibroblasts. We will summarize these recent results and offer explanations, whenever possible, and hypotheses when not. For these studies we will rely heavily on our models and those of others to reconcile some of the apparent inconsistencies in the literature.

For those that view cellular signaling as a tangled mass of cooked spaghetti, a guidebook that introduces shared principles, highlights typical behaviors, and provides clear examples of the uses for these critical pathways should be invaluable. This book provides all of that and more. But it also, perhaps inadvertently, highlights overly reductionist concepts of cellular control. Hopefully, this tome will close the book on that mode of thought and stimulate a new generation to think about and understand how cellular regulation is so tightly integratedŚbecause this is the key to more effective treatments for disease.
//stke.sciencemag.org/lookup/reprint/sigtrans/7/347/pe25?ijkey=2Xv0AbaXg8ugw&keytype=ref&siteid=sigtrans>Reprint; //stke.sciencemag.org/cgi/content/full/sigtrans/7/347/pe25?ijkey=2Xv0AbaXg8ugw&keytype=ref&siteid=sigtrans>Full Text


Illinois State Fair: Twilight Parade, ribbon-cutting highlight opening day
Aug 8, 2018 at 5:39 PM Aug 9, 2018 at 11:10 AM
It's opening day of the 2018 Illinois State Fair. Here's what you need to know.
Ribbon-cutting
Gov. Bruce Rauner and other dignitaries will be at the fairgrounds' Main Gate at 3 p.m. to cut the ribbon on the Illinois State Fair.
At the conclusion of the ribbon cutting at the Main Gate, the Agriculture director Raymond Poe will travel to the Department of Agriculture tent for a tour and a ceremonial ribbon cutting. Rauner will go to the Governor's Tent to cut the ribbon there about 3:45 p.m.
Twilight Parade
The annual Twilight Parade will step off at 5:30 p.m. from inside Lincoln Park and travel north to Sangamon Avenue. From there, it will travel east across Sangamon Avenue into the Main Gate of the fairgrounds and proceed on to the Grandstand.
This year's parade has about 60 entries. The State Journal-Register plans to livestream the parade on its Facebook page, www.fb.com/statejournalregister.
The Wiseman Family, which owns the Wiseman Farm in Wabash County, will be the Grand Marshals for the parade, fair officials announced Thursday.
The Wisemans have been recognized as one of only two Bicentennial Farm families in Illinois. They grow corn and soybeans on their land, which has been in their family since 1818.
“Very few families can say they’ve owned the same farm ground since the year Illinois was founded. That’s a tremendous feat,” Poe said. “The Wisemans have shown their commitment to building Illinois’ greatest industry and we are proud to have them join us for the Fair this year.”
The Wisemans are descendants of William Tanquary, who first purchased the farm land outside Bellmont in August of 1818. The family says the original land deed was signed by President James Monroe but was lost when the Tanquary family home burned in 1975. The farm was passed down through generations to Nell (Tanquary) Wiseman, the late wife of current owner Dr. Robert Wiseman.
The Springfield Park District is alerting the public that several one-day changes will be in effect at Lincoln Park Thursday to accommodate the parade.
This year marks the second year that the kickoff for the parade will start inside Lincoln Park, 1601 N. Fifth St., instead of Ninth Street and North Grand Avenue. Due to the large number of floats and parade participants gathering at the park, the district has implemented the following changes for Thursday.
There will be no public hours at the Nelson Center Pool on Thursday.
• Spectators who want to view the parade will not be allowed to park vehicles inside Lincoln Park. People can view the parade from inside the park, but they will have to park their vehicles outside the park.
• People who visit Lincoln Park prior to the parade to walk or jog are encouraged to get their vehicles out of the park by 1 or 1:30 p.m. due to the fact that entering and exiting traffic flow at the park will change at 2 p.m. Starting at 2 p.m., vehicles will be allowed to leave the park, but only vehicles registered to be in the parade will be allowed into the park. Starting at 4 p.m., no vehicles will be allowed in or out of the park until the parade concludes, possibly around 7 or 7:30 p.m.
• The best place to drop off a parade participant is the west entrance to Lincoln Park on First Street.
On the fairgrounds
Admission to the fairgrounds on Thursday is $5 for adults, $3 for seniors, and kids 12 and younger get in free. All carnival rides, including those in Adventure Village, will be open by 5 p.m. and offered at a discounted price.
Following the Twilight Parade, free concerts will be offered on the Rising Star Stage, on Central Avenue just east of The Shed. Logan Mize takes the Rising Star Stage at 7 p.m., followed by ClusterPluck at 8 p.m.


UL Benchmarks has announced that four Huawei phones, including the popular P20 and P20 Pro flagships, have been delisted from its 3DMark rankings. The decision comes after the Chinese smartphone maker, which recently surpassed Apple to become the second largest smartphone vendor in the world, was found to have cheated in order to get higher scores.
The discovery was initially made by AnandTech earlier this week, which prompted the company behind the benchmarking tool to conduct their own testing. In order to determine if Huawei had tricked the system, the company used two versions - the publicly available variant and a private one that can't be recognized by phones - of its benchmarking app to test the devices' performance. The results showed that scores were noticeably higher with the public version of the app.
This isn't the first case of manufacturers attempting to rig benchmark results to favor their own smartphones. Back in 2013, many companies were caught doing something similar with their devices. It's a reminder that benchmark scores shouldn't be taken too seriously, as they might not always reflect real-life performance.