diff --git "a/raw_rss_feeds/https___www_nature_com_nature_rss.xml" "b/raw_rss_feeds/https___www_nature_com_nature_rss.xml" --- "a/raw_rss_feeds/https___www_nature_com_nature_rss.xml" +++ "b/raw_rss_feeds/https___www_nature_com_nature_rss.xml" @@ -18,155 +18,155 @@ - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -177,6 +177,501 @@ http://feeds.nature.com/nature/rss/current + + <![CDATA[Australia’s world-first social media ban is a ‘natural experiment’ for scientists]]> + https://www.nature.com/articles/d41586-025-04069-2 + + Nature, Published online: 11 December 2025; doi:10.1038/d41586-025-04069-2

Researchers will study the effects of the policy on young people’s mental health, social interactions and political engagement.]]> + + Rachel FieldhouseMohana Basu + doi:10.1038/d41586-025-04069-2 + Nature, Published online: 2025-12-11; | doi:10.1038/d41586-025-04069-2 + 2025-12-11 + Nature + 10.1038/d41586-025-04069-2 + https://www.nature.com/articles/d41586-025-04069-2 + + + + <![CDATA[This AI model ‘studied’ physics — and learnt to forecast extreme weather]]> + https://www.nature.com/articles/d41586-025-04055-8 + + Nature, Published online: 11 December 2025; doi:10.1038/d41586-025-04055-8

Combining artificial intelligence with a conventional climate model can predict heatwaves faster than the standard model alone.]]> + + Alexandra Witze + doi:10.1038/d41586-025-04055-8 + Nature, Published online: 2025-12-11; | doi:10.1038/d41586-025-04055-8 + 2025-12-11 + Nature + 10.1038/d41586-025-04055-8 + https://www.nature.com/articles/d41586-025-04055-8 + + + + <![CDATA[Glimmers of hope for a deadly disease]]> + https://www.nature.com/articles/d41586-025-03941-5 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03941-5

New models, efforts for early detection and better therapies may help change pancreatic cancer’s aggressive course.]]> + + Shraddha Chakradhar + doi:10.1038/d41586-025-03941-5 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03941-5 + 2025-12-10 + Nature + 10.1038/d41586-025-03941-5 + https://www.nature.com/articles/d41586-025-03941-5 + + + + <![CDATA[Will young universities set the pace in the age of AI?]]> + https://www.nature.com/articles/d41586-025-03949-x + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03949-x

Why some institutions are betting on technology to stay relevant.]]> + + Bec Crew + doi:10.1038/d41586-025-03949-x + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03949-x + 2025-12-10 + Nature + 10.1038/d41586-025-03949-x + https://www.nature.com/articles/d41586-025-03949-x + + + + <![CDATA[Exposing a silent cancer]]> + https://www.nature.com/articles/d41586-025-03942-4 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03942-4

Pancreatic cancer is one of the deadliest malignancies, and it is increasingly occurring in young people — especially women. An uptick in research funding is a welcome development in the push to transform treatment.]]> + + Rachel Nuwer + doi:10.1038/d41586-025-03942-4 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03942-4 + 2025-12-10 + Nature + 10.1038/d41586-025-03942-4 + https://www.nature.com/articles/d41586-025-03942-4 + + + + <![CDATA[Neanderthals mastered fire — 400,000 years ago]]> + https://www.nature.com/articles/d41586-025-04059-4 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-04059-4

Archaeological evidence makes a compelling case for Neanderthal-created fires 400,000 years ago in Suffolk, UK — plus, how chatbots can sway the opinions of voters.]]> + + Nick Petrić HoweAnne Marie Conlon + doi:10.1038/d41586-025-04059-4 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-04059-4 + 2025-12-10 + Nature + 10.1038/d41586-025-04059-4 + https://www.nature.com/articles/d41586-025-04059-4 + + + + <![CDATA[Fasting boosts breast cancer therapy efficacy via glucocorticoid activation]]> + https://www.nature.com/articles/s41586-025-09869-0 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09869-0

Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor-α-expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting to reduce harmful effects.]]> + + Nuno PadrãoTesa M. SeversonSebastian GregoricchioAna GuijarroCatrin LutzDaniel TarantoStefan HuttenFrancesca LigorioAngelica PersiaMerel RoestJoyce SandersJi-Ying SongSara Pires-OliveiraMaria Donaldson CollierHugo HorlingsLivia PisciottaFilippo de BraudClaudio VernieriLeila AkkariJos JonkersAlessio NencioniIrene CaffaWilbert Zwart + doi:10.1038/s41586-025-09869-0 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09869-0 + 2025-12-10 + Nature + 10.1038/s41586-025-09869-0 + https://www.nature.com/articles/s41586-025-09869-0 + + + + <![CDATA[The influence of short-lived halogens on atmospheric chemistry and climate]]> + https://www.nature.com/articles/s41586-025-09753-x + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09753-x

A Review of the impacts of short-lived halogens on air quality and climate identifies gaps in our knowledge of short-lived halogen emissions, chemistry, and the environmental and climate impacts.]]> + + Alfonso Saiz-LopezAnoop S. MahajanJonathan AbbattNicole BobrowskiSteven S. BrownJohn P. BurrowsLucy J. CarpenterMartyn P. ChipperfieldCarlos A. CuevasRafael P. FernandezRyan HossainiDouglas E. KinnisonJean-Francois LamarqueBarbara J. Finlayson-PittsJohn M. C. PlaneUlrich PlattKerri A. PrattA. R. RavishankaraRoss J. SalawitchEric S. SaltzmanWilliam R. SimpsonSusan SolomonJoel A. ThorntonTao Wang + doi:10.1038/s41586-025-09753-x + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09753-x + 2025-12-10 + Nature + 10.1038/s41586-025-09753-x + https://www.nature.com/articles/s41586-025-09753-x + + + + <![CDATA[Quantifying grain boundary deformation mechanisms in small-grained metals]]> + https://www.nature.com/articles/s41586-025-09800-7 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09800-7

Experimental observations in small-grained polycrystals suggest a new concept of considering metallic grain boundaries not as defects but as separate defect-containing lattices, providing a potential explanation for the deformation behaviour of nanocrystalline metals.]]> + + Romain GautierFrédéric MompiouOliver RenkChristophe CoupeauNicolas CombeGregory SeineMarc Legros + doi:10.1038/s41586-025-09800-7 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09800-7 + 2025-12-10 + Nature + 10.1038/s41586-025-09800-7 + https://www.nature.com/articles/s41586-025-09800-7 + + + + <![CDATA[Gene-drive-capable mosquitoes suppress patient-derived malaria in Tanzania]]> + https://www.nature.com/articles/s41586-025-09685-6 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09685-6

Engineering of local Anopheles gambiae under containment enables the generation of a transgenic strain equipped with non-autonomous gene drive capabilities that robustly inhibits genetically diverse Plasmodium falciparum isolates obtained from naturally infected children.]]> + + Tibebu HabtewoldDickson Wilson LwetoijeraAstrid HoermannRajabu MashauriFatuma MatweweRehema MwangaPrisca KweyambaGilbert MagangaBeatrice Philip MaganiRachel MtamaMoze Ally MahonjeMgeni Mohamed TambweFelista TarimoPratima R. ChennuriJulia A. CaiGiuseppe Del CorsanoPaolo CapriottiPeter SasseJason MooreDouglas HudsonAlphaxard ManjuranoBrian TarimoDina VlachouSarah MooreNikolai WindbichlerGeorge K. Christophides + doi:10.1038/s41586-025-09685-6 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09685-6 + 2025-12-10 + Nature + 10.1038/s41586-025-09685-6 + https://www.nature.com/articles/s41586-025-09685-6 + + + + <![CDATA[Erythropoietin receptor on cDC1s dictates immune tolerance]]> + https://www.nature.com/articles/s41586-025-09824-z + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09824-z

The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.]]> + + Xiangyue ZhangChristopher S. McGinnisGuotao YuSijie ChenPingping ZhengChristian M. SchürchKamir J. Hiam-GalvezNathan E. Reticker-FlynnWenhui GuoWinnie YaoJingtao QiuAlexander MuselmanIan L. LindeJohn W. HickeyHao YanVictoria M. TranWenli QiuDelphine Brichart-VernosToshihito HiraiBo YuXiuli AnYanling XiaoHelena PaidassiTiffany C. ScharschmidtMichael AngeloDean SheppardHongbo ChiAnsuman T. SatpathySing Sing WayBernard MalissenSamuel StroberEdgar G. Engleman + doi:10.1038/s41586-025-09824-z + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09824-z + 2025-12-10 + Nature + 10.1038/s41586-025-09824-z + https://www.nature.com/articles/s41586-025-09824-z + + + + <![CDATA[Human gut M cells resemble dendritic cells and present gluten antigen]]> + https://www.nature.com/articles/s41586-025-09829-8 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09829-8

An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune system via the class II major histocompatibility complex.]]> + + Daisong WangSangho LimWilline J. van de WeteringCarmen Lopez-IglesiasYuu OkuraYuri Teranishi-IkawaAkihiko MizorokiWillem Kasper SpoelstraTalya DaytonGijs J. F. van SonApollo PronkNiels SmakmanGieneke B. C. Gonera-de JongSebo WithoffIris H. JonkersJeroen S. van ZonSander J. TansPeter J. PetersJohan H. van EsHans Clevers + doi:10.1038/s41586-025-09829-8 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09829-8 + 2025-12-10 + Nature + 10.1038/s41586-025-09829-8 + https://www.nature.com/articles/s41586-025-09829-8 + + + + <![CDATA[Cross-regulation of [2Fe–2S] cluster synthesis by ferredoxin-2 and frataxin]]> + https://www.nature.com/articles/s41586-025-09822-1 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09822-1

A finely balanced ratio of ferredoxin-2 (FDX2) and frataxin (FXN) is essential for the synthesis of iron–sulfur clusters, and interventions targeting this ratio could provide a way to treat related diseases, such as Friedreich’s ataxia.]]> + + Kristian WantHubert GornyEma TurkiMagali NoirayBeata MonfortRémi Mor-GautierThibault TubianaEstelle JullianVéronique MonnierBenoit D’Autréaux + doi:10.1038/s41586-025-09822-1 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09822-1 + 2025-12-10 + Nature + 10.1038/s41586-025-09822-1 + https://www.nature.com/articles/s41586-025-09822-1 + + + + <![CDATA[Sterilization and contraception increase lifespan across vertebrates]]> + https://www.nature.com/articles/s41586-025-09836-9 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09836-9

Data collected from zoos and aquariums worldwide show that hormonal contraception or permanent surgical sterilization in mammals increase life expectancy, with different mechanisms in males and females.]]> + + Michael GarrattMalgorzata LagiszJohanna StaerkChristine NeytMichael B. StoutJosé V. V. IsolaVeronica B. CowlNannette Driver-RuizAshley D. FranklinMonica M. McDonaldDavid M. PowellSusan L. WalkerJean-Michel GaillardDalia A. CondeJean-François LemaîtreFernando ColcheroShinichi Nakagawa + doi:10.1038/s41586-025-09836-9 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09836-9 + 2025-12-10 + Nature + 10.1038/s41586-025-09836-9 + https://www.nature.com/articles/s41586-025-09836-9 + + + + <![CDATA[Earliest evidence of making fire]]> + https://www.nature.com/articles/s41586-025-09855-6 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09855-6

Baked sediment, heat-shattered artefacts and introduced pyrite in a 400,000-year-old Palaeolithic occupation site in Suffolk, UK provide evidence of intentional fire-making, marking a pivotal moment in human development.]]> + + Rob DavisMarcus HatchSally HoareSimon G. LewisClaire LucasSimon A. ParfittSilvia M. BelloMark LewisJordan MansfieldJens NajorkaSimon O’ConnorSylvia PeglarAndrew SorensenChris StringerNick Ashton + doi:10.1038/s41586-025-09855-6 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09855-6 + 2025-12-10 + Nature + 10.1038/s41586-025-09855-6 + https://www.nature.com/articles/s41586-025-09855-6 + + + + <![CDATA[Observation of deuteron and antideuteron formation from resonance-decay nucleons]]> + https://www.nature.com/articles/s41586-025-09775-5 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09775-5

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.]]> + + S. AcharyaA. AgarwalG. Aglieri RinellaL. AgliettaM. AgnelloN. AgrawalZ. AhammedS. AhmadS. U. AhnI. AhujaA. AkindinovV. AkishinaM. Al-TuranyD. AleksandrovB. AlessandroH. M. AlfandaR. Alfaro MolinaB. AliA. AliciN. AlizadehvandchaliA. AlkinJ. AlmeG. AloccoT. AltA. R. AltamuraI. AltsybeevJ. R. AlvaradoM. N. AnaamC. AndreiN. AndreouA. AndronicE. AndronovV. AnguelovF. AntinoriP. AntonioliN. ApadulaH. AppelshäuserC. ArataS. ArcelliR. ArnaldiJ. G. M. C. A. ArneiroI. C. ArseneM. ArslandokA. AugustinusR. AverbeckD. AveryanovM. D. AzmiH. BabaA. BadalàJ. BaeY. BaeY. W. BaekX. BaiR. BailhacheY. BailungR. BalaA. BaldisseriB. BalisS. BangaliaZ. BanooV. BarbasovaF. BarileL. BarioglioM. BarlouB. BarmanG. G. BarnaföldiL. S. BarnbyE. BarreauV. BarretL. BarretoK. BarthE. BartschN. BastidS. BasuG. BatigneD. BattistiniB. BatyunyaD. BauriJ. L. Bazo AlbaI. G. BeardenP. BechtD. BeheraI. BelikovA. D. C. Bell HechavarriaF. BelliniR. BellwiedS. BelokurovaL. G. E. BeltranY. A. V. BeltranG. BencediA. BensaoulaS. BeoleY. BerdnikovA. BerdnikovaL. BergmannL. BernardinisL. BetevP. P. BhaduriT. BhallaA. BhasinB. BhattacharjeeS. BhattaraiL. BianchiJ. BielčkJ. BielčkováA. P. BigotA. BilandzicA. BinoyG. BiroS. BiswasN. BizeD. BlauM. B. BlidaruN. BluhmeC. BlumeF. BockT. BodovaJ. BokL. BoldizsárM. BombaraP. M. BondG. BonomiH. BorelA. BorissovA. G. Borquez CarcamoE. BottaY. E. M. BouzianiD. C. BrandiburL. BratrudP. Braun-MunzingerM. BregantM. BrozG. E. BrunoV. D. BuchakchievM. D. BucklandD. BudnikovH. BueschingS. BufalinoP. BuhlerN. BurmasovZ. ButheleziA. BylinkinS. A. BysiakJ. C. Cabanillas NorisM. F. T. CabreraH. CainesA. CalivaE. Calvo VillarJ. M. M. CamachoP. CameriniM. T. CamerlingoF. D. M. CanedoS. CannitoS. L. CantwayM. CarabasF. CarnesecchiL. A. D. CarvalhoJ. Castillo CastellanosM. CastoldiF. CatalanoS. CattaruzziR. CerriI. ChakaberiaP. ChakrabortyS. ChandraS. ChapelandM. ChartierS. ChattopadhayM. ChenT. ChengC. CheshkovD. ChiapparaV. Chibante BarrosoD. D. ChinellatoF. ChinuE. S. ChizzaliJ. ChoS. ChoP. ChochulaZ. A. ChochulskaD. ChoudhuryS. ChoudhuryP. ChristakoglouC. H. ChristensenP. ChristiansenT. ChujoM. CiaccoC. CicaloG. CimadorF. CindoloM. R. CiupekG. ClaiF. ColamariaJ. S. ColburnD. ColellaA. ColelliM. ColocciM. ConcasG. Conesa BalbastreZ. Conesa del ValleG. ContinJ. G. ContrerasM. L. CoquetP. CorteseM. R. CosentinoF. CostaS. CostanzaP. CrochetM. M. CzarnynogaA. DaineseG. DangeM. C. DanischA. DanuP. DasS. DasA. R. DashS. DashA. De CaroG. de CataldoJ. de CuvelandA. De FalcoD. De GruttolaN. DeMarcoC. De MartinS. DePasqualeR. DebR. DelGrandeL. Dello StrittoG. G. A. de SouzaP. DhankherD. DiBariM. Di CostanzoA. Di MauroB. Di RuzzaB. DiabR. A. DiazY. DingJ. DitzelR. DiviàØ. DjuvslandU. DmitrievaA. DobrinB. DönigusJ. M. DubinskiA. DublaP. DupieuxN. DzalaiovaT. M. EderR. J. EhlersF. EisenhutR. EjimaD. EliaB. ErazmusF. ErcolessiB. EspagnonG. EulisseD. EvansS. EvdokimovL. FabbiettiM. FagginJ. FaivreF. FanW. FanT. FangA. FantoniM. FaselG. FeofilovA. Fernández TéllezL. FerrandiM. B. FerrerA. FerreroC. FerreroA. FerrettiV. J. G. FeuillardV. FilovaD. FinogeevF. M. FiondaF. FlorA. N. FloresS. FoertschI. FokinS. FokinU. FolloE. FragiacomoE. FrajnaH. FribertU. FuchsN. FunicelloC. FurgetA. FursT. FusayasuJ. J. GaardhøjeM. GagliardiA. M. GagoT. GahlautC. D. GalvanS. GamiD. R. GangadharanP. GanotiC. GarabatosJ. M. GarciaT. García ChávezE. Garcia-SolisS. GarettiC. GargiuloP. GasikH. M. GaurA. GautamM. B. Gay DucatiM. GermainR. A. GernhaeuserC. GhoshM. GiacaloneG. GioachinS. K. GiriP. GiubellinoP. GiubilatoA. M. C. GlaenzerP. GlässelE. GlimosV. GonzalezP. GordeevM. GorgonK. GoswamiS. GotovacV. GrabskiL. K. GraczykowskiE. GreckaA. GrelliC. GrigorasV. GrigorievS. GrigoryanO. S. GroettvikF. GrosaJ. F. Grosse-OetringhausR. GrossoD. GrundN. A. GrunwaldR. GuernaneM. GuilbaudK. GulbrandsenJ. K. GumprechtT. GündemT. GunjiJ. GuoW. GuoA. GuptaR. GuptaR. GuptaK. GwizdzielL. GyulaiC. HadjidakisF. U. HaiderS. HaidlovaM. HaldarH. HamagakiY. HanB. G. HanleyR. HanniganJ. HansenJ. W. HarrisA. HartonM. V. HartungH. HassanD. HatzifotiadouP. HauerL. B. HavenerE. HellbärH. HelstrupM. HemmerT. HermanS. G. HernandezG. Herrera CorralS. HerrmannK. F. HetlandB. HeybeckH. HillemannsB. HippolyteI. P. M. HobusF. W. HoffmannB. HofmanA. HorzykY. HouP. HristovP. HuhnL. M. HuhtaT. J. HumanicA. HutsonD. HutterM. C. HwangR. IlkaevM. InabaM. IppolitovA. IsakovT. IsidoriM. S. IslamS. IurchenkoM. IvanovM. IvanovV. IvanovK. E. IversenM. JablonskiB. JacakN. JacazioP. M. JacobsS. JadlovskaJ. JadlovskyS. JaelaniC. JahnkeM. J. JakubowskaM. A. JanikS. JiS. JiaT. JiangA. A. P. JimenezS. JinF. JonasD. M. JonesJ. M. JowettJ. JungM. JungA. JuniqueA. JuskoJ. KaewjaiP. KalinakA. KalweitA. Karasu UysalN. KaratzenisO. KaravichevT. KaravichevaE. KarpechevM. J. KarwowskaU. KebschullM. KeilB. KetzerJ. KeulS. S. KhadeA. M. KhanS. KhanA. KhanzadeevY. KharlovA. KhatunA. KhuntiaZ. KhuranovaB. KilengB. KimC. KimD. J. KimD. KimE. J. KimG. KimH. KimJ. KimJ. KimJ. KimM. KimS. KimT. KimK. KimuraS. KirschI. KiselS. KiselevA. KisielJ. L. KlayJ. KleinS. KleinC. Klein-BösingM. KleinerT. KlemenzA. KlugeC. KobdajR. KoharaT. KolleggerA. KondratyevN. KondratyevaJ. KonigS. A. KonigstorferP. J. KonopkaG. KornakovM. KorwieserS. D. KoryciakC. KosterA. KotliarovN. KovacicV. KovalenkoM. KowalskiV. KozhuharovG. KozlovI. KrálikA. KravčákováL. KrcalM. KrivdaF. KrizekK. Krizkova GajdosovaC. KrugM. KrügerD. M. KrupovaE. KryshenV. KučeraC. KuhnP. G. KuijerT. KumaokaD. KumarL. KumarN. KumarS. KumarS. KunduM. KuoP. KurashviliA. B. KurepinA. KuryakinS. KushpilV. KuskovM. KutylaA. KuznetsovM. J. KweonY. KwonS. L. LaPointeP. LaRoccaA. LakrathokM. LamannaS. LambertA. R. LandouR. LangoyP. LarionovE. LaudiL. LautnerR. A. N. LaveagaR. LavickaR. LeaH. LeeI. LegrandG. LegrasA. M. LejeuneT. M. LelekR. C. LemmonI. León MonzónM. M. LeschP. LévaiM. LiP. LiX. LiB. E. Liang-GilmanJ. LienR. LietavaI. LikmetaB. LimH. LimS. H. LimS. LinV. LindenstruthC. LippmannD. LiskovaD. H. LiuJ. LiuG. S. S. LiveraroI. M. LofnesC. LoizidesS. LokosJ. LömkerX. LopezE. López TorresC. LotteauP. LuW. LuZ. LuF. V. LugoJ. LuoG. LuparelloM. A. T. JohnsonY. G. MaM. MagerM. MahleinA. MaireE. M. MajerzM. V. MakarievM. MalaevG. MalfattoreN. M. MalikN. MalikS. K. MalikD. MallickN. MallickG. MandaglioS. K. MandalA. ManeaV. MankoA. K. MannaF. MansoG. MantzaridisV. ManzariY. MaoR. W. MarcjanG. V. MargagliottiA. MargottiA. MarnC. MarkertP. MartinengoM. I. MartínezG. Martínez GarcíaM. P. P. MartinsS. MasciocchiM. MaseraA. MasoniL. MassacrierO. MassenA. MastroserioL. MatteiS. MattiazzoA. MatyjaF. MazzaschiM. MazzilliY. MelikyanM. MeloA. Menchaca-RochaJ. E. M. MendezE. MeninnoA. S. MenonM. W. MenzelM. MeresL. MichelettiD. MihaiD. L. MihaylovA. U. MikalsenK. MikhaylovN. MinafraD. MiśkowiecA. ModakB. MohantyM. Mohisin KhanM. A. 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SamitzI. SannaT. B. SaramelaD. SarkarP. SarmaV. SarritzuV. M. SartiM. H. P. SasS. SawanE. ScapparoneJ. SchambachH. S. ScheidC. SchiauaR. SchickerF. SchlepperA. SchmahC. SchmidtM. O. SchmidtM. SchmidtN. V. SchmidtA. R. SchmierJ. SchoengarthR. SchotterA. SchröterJ. SchukraftK. SchwedaG. ScioliE. ScomparinJ. E. SegerY. SekiguchiD. SekihataM. SelinaI. SelyuzhenkovS. SenyukovJ. J. SeoD. SerebryakovL. SerkinL. ŠerkšnytėA. SevcencoT. J. ShabaA. ShabetaiR. ShahoyanA. ShangaraevB. SharmaD. SharmaH. SharmaM. SharmaS. SharmaT. SharmaU. SharmaA. ShatatO. SheibaniK. ShigakiM. ShimomuraS. ShirinkinQ. ShouY. SibiriakS. SiddhantaT. SiemiarczukT. F. SilvaD. SilvermyrT. SimantathammakulR. SimeonovB. SinghB. SinghK. SinghR. SinghR. SinghS. SinghV. K. SinghV. SinghalT. SinhaB. SitarM. SittaT. B. SkaaliG. SkorodumovsN. SmirnovR. J. M. SnellingsE. H. SolheimC. SonnabendJ. M. SonneveldF. SoramelA. B. Soto-HernandezR. SpijkersI. SputowskaJ. StaaJ. StachelI. StanT. StellhornS. F. StiefelmaierD. StoccoI. 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VillaniA. VinogradovT. VirgiliM. M. O. VirtaA. VodopyanovB. VolkelM. A. VölklS. A. VoloshinG. VolpeB. vonHallerI. VorobyevN. VozniukJ. VrlákováJ. WanC. WangD. WangY. WangY. WangZ. WangA. WegrzynekF. WeiglhoferS. C. WenzelJ. P. WesselsP. K. WiacekJ. WiechulaJ. WikneG. WilkJ. WilkinsonG. A. WillemsB. WindelbandM. WinnJ. R. WrightW. WuY. WuK. XiongZ. XiongR. XuA. YadavA. K. YadavY. YamaguchiS. YangS. YangS. YanoE. R. YeatsJ. YiZ. YinI.-K. YooJ. H. YoonH. YuS. YuanA. YuncuV. ZaccoloC. ZampolliF. ZanoneN. ZardoshtiP. ZávadaM. ZhalovB. ZhangC. ZhangL. ZhangM. ZhangM. ZhangS. ZhangX. ZhangY. ZhangZ. ZhangM. ZhaoV. ZherebchevskiiY. ZhiD. ZhouY. ZhouJ. ZhuS. ZhuY. ZhuS. C. ZugravelN. Zurlo + doi:10.1038/s41586-025-09775-5 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09775-5 + 2025-12-10 + Nature + 10.1038/s41586-025-09775-5 + https://www.nature.com/articles/s41586-025-09775-5 + + + + <![CDATA[Hot droughts in the Amazon provide a window to a future hypertropical climate]]> + https://www.nature.com/articles/s41586-025-09728-y + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09728-y

Thirty years of forest demographic data, combined with recent ecophysiological measurements, reveal that intense Amazon droughts sharply increase tree mortality once soil moisture falls below a threshold, and that these hot droughts will become more frequent and intense as Earth warms towards hypertropical conditions.]]> + + Jeffrey Q. ChambersAdriano José Nogueira LimaGilberto PastorelloBruno Oliva GimenezLin MengLee A. DyerYanlei FengCristina Santos da SilvaRegison Costa de OliveiraAnna WeberCharlie KovenRobinson Negrón-JuárezGustavo C. SpannerTatiana D. GauiClarissa G. FontesAlessandro C. de AraújoNate McDowellRuby LeungDaniel Magnabosco MarraJeffrey WarrenDaisy Celestina SouzaCynthia WrightKolby JardineMarcos LongoChonggang XuPaul V. A. FineRosie A. FisherJavier TomasellaJoaquim dos SantosNiro Higuchi + doi:10.1038/s41586-025-09728-y + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09728-y + 2025-12-10 + Nature + 10.1038/s41586-025-09728-y + https://www.nature.com/articles/s41586-025-09728-y + + + + <![CDATA[A direct role for a mitochondrial targeting sequence in signalling stress]]> + https://www.nature.com/articles/s41586-025-09834-x + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09834-x

Cells can sense mitochondrial damage through signalling via an unimported mitochondrial targeting sequence.]]> + + Zixuan YuanMegan BalzariniMarina VolpeMadeleine GoldsteinTony Shengzhe PengElizabeth HuiNancy Neng FangWaleed S. AlbihlalMelika HajimohammadiKevin WeiCalvin K. YipFolkert J. van WervenThibault MayorHilla Weidberg + doi:10.1038/s41586-025-09834-x + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09834-x + 2025-12-10 + Nature + 10.1038/s41586-025-09834-x + https://www.nature.com/articles/s41586-025-09834-x + + + + <![CDATA[Neutrophils preserve energy storage in sympathetically activated adipocytes]]> + https://www.nature.com/articles/s41586-025-09839-6 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09839-6

Neutrophil-derived IL-1β has a role in preserving lipid stores during metabolic stress.]]> + + Seunghwan SonCindy XuHaipeng FuChuraibhon WisessaowapakJoseph M. ValentineGaram AnJanice JangMaddox DinhYang DaiWeiwei FanRuth T. YuMichael DownesWei YingYuliya SkorobogatkoRonald M. EvansAlan R. Saltiel + doi:10.1038/s41586-025-09839-6 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09839-6 + 2025-12-10 + Nature + 10.1038/s41586-025-09839-6 + https://www.nature.com/articles/s41586-025-09839-6 + + + + <![CDATA[Mapping the genetic landscape across 14 psychiatric disorders]]> + https://www.nature.com/articles/s41586-025-09820-3 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09820-3

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.]]> + + Andrew D. GrotzingerJosefin WermeWouter J. PeyrotOleksandr FreiChristiaan de LeeuwLucy K. BicksQiuyu GuoMichael P. MargolisBrandon J. CoombesAnthony BatzlerVanessa PazdernikJoanna M. BiernackaOle A. AndreassenVerneri AnttilaAnders D. BørglumGerome BreenNa CaiDitte DemontisHoward J. EdenbergStephen V. FaraoneBarbara FrankeMichael J. GandalJoel GelernterAlexander S. HatoumJohn M. HettemaEmma C. JohnsonKatherine G. JonasJames A. KnowlesKarestan C. KoenenAdam X. MaihoferTravis T. MallardManuel MattheisenKaren S. MitchellBenjamin M. NealeCaroline M. NievergeltJohn I. NurnbergerKevin S. O’ConnellRoseann E. PetersonElise B. RobinsonSandra S. Sanchez-RoigeSusan L. SantangeloJeremiah M. ScharfHreinn StefanssonKari StefanssonMurray B. SteinNora I. StromLaura M. ThorntonElliot M. Tucker-DrobBrad VerhulstIrwin D. WaldmanG. Bragi WaltersNaomi R. WrayDongmei YuDaniel E. AdkinsGeorg W. AlpersHelga AskSintia I. BelangeroOttar BjerkesetSigrid BørteSandra A. BrownEnrique CastelaoHilary CoonWilliam E. CopelandElizabeth C. CorfieldDarina CzamaraJürgen DeckertAnna R. DochertyKatharina DomschkeOle Kristian DrangeThalia C. EleyAngelika Erhardt-LehmannAndreas J. ForstnerMiguel Garcia-ArgibayScott D. GordonIan B. HickieIiris HovattaMatthew H. IvesonJames L. KennedyHenrik LarssonDaniel F. LeveyChristine LochnerMichelle K. LuptonHermine HM MaesEduard MaronNicholas G. MartinSandra M. MeierChristiane A. MelzigBrittany L. MitchellTeemu PalviainenGiorgio PistisMartin PreisigBörge SchmidtJohannes SchumacherAndrey A. ShabalinAnne Heidi SkogholtDan J. SteinEystein StordalAndreas StröhleElisa TasankoLaurent ThomasHenning TiemeierHeike WeberBendik S. WinsvoldClement C. ZaiGwyneth ZaiJohn-Anker ZwartSilvia AlemanyClaiton HD BauDorret I. BoomsmaRosa BoschIsabell BrikellChristie L. BurtonMiquel CasasBru CormandJennifer CrosbieAlysa E. DoyleJosephine EliaJoseph T. GlessnerEugenio H. GrevetJan HaavikAlexandra HavdahlZiarih HawiAnke HinneyDaniel P. HowriganMarieke KleinHenry R. KranzlerJonna KuntsiKate LangleyKlaus-Peter LeschCalwing LiaoSandra K. LooJames J. McGoughSarah E. MedlandNina R. MotaMichael C. O’DonovanDanielle PosthumaJosep Antoni Ramos-QuirogaAndreas ReifMarta RibasésDiego L. RovarisRussell J. SchacharStephen W. SchererYingjie ShiMaría Soler ArtigasEdmund JS Sonuga-BarkeHans-Christoph SteinhausenLudger Tebartz van ElstMartin TesliRaymond K. WaltersStephanie H. WittYanli Zhang-JamesEdwin H. CookJakob GroveSusan S. KuoJoseph PivenStephan J. SandersMohammed UddinJacob AS VorstmanVarun WarrierLauren A. WeissMartin AldaLars AlfredssonTill F. M. AndlauerNicholas BassAnthony J. BatzlerBernhard T. BauneEva C. BeinsTim B. BigdeliSven CichonJonathan RI ColemanAlfredo B. Cuellar-BarbozaUdo DannlowskiFriederike S. DavidJosef FrankJanice M. FullertonFernando S. GoesMaria Grigoroiu-SerbanescuPer HoffmannJanos L. KalmanKristi KrebsMikael LandénCathryn M. LewisQingqin S. LiPenelope A. LindJurjen J. LuykxMirko ManchiaMorten MattingsdalAndrew M. McIntoshAndrew McQuillinAnna MeloniLili MilaniPhilip B. MitchellDerek W. MorrisNiamh MullinsWoojae MyungJohn I. Nurnberger JrRoel A. OphoffMichael J. OwenGeorge P. PatrinosClaudia PisanuJames J. PrisciandaroEva Z. ReininghausJohn P. RiceMarcella RietschelEva C. SchulteAlessandro SerrettiLea SirignanoAlessio SquassinaFabian StreitJana StrohmaierTracey van der VeenMarquis P. VawterJohn B. VincentPeter P. ZandiLea ZillichRoger A. AdanAndreas BirgegårdCynthia M. BulikChristian DinaMonika Dmitrzak-WeglarzElisa DocampoKarin M. EgbertsFernando Fernandez-ArandaKatrin E. GielPhilip GorwoodChristopher HübelJames I. HudsonSusana Jimenez-MurciaJennifer JordanGursharan K. KalsiJaakko KaprioLeila KarhunenMartien J. H. KasMartin A. KennedyJanne T. LarsenLisa R. LilenfeldAlessio Maria MonteleoneMelissa A. Munn-ChernoffBenedetta NacmiasLiselotte V. PetersenDalila PintoAnu RaevuoriNicolas RamozValdo RiccaMarion E. RobertsFilip RybakowskiUlrike H. SchmidtAlexandra SchosserSandro SorbiMichael A. StroberHunna J. WatsonStephan ZipfelMark J. AdamsMichael E. BenrosRodrigo A. BressanEnda M. ByrneCarolina M. CarvalhoBoris ChaumetteLucia Colodro-CondeEske M. DerksErin C. DunnChiara FabbriGiuseppe FanelliJerome C. FooAry GadelhaZachary F. GerringHans J. GrabeAndrew C. HeathKelli LehtoDouglas F. LevinsonGlyn LewisVanessa K. OtaPedro M. PanPeristera PaschouJames B. PotashBrien P. RileyGiovanni A. SalumMarcos L. SantoroJackson G. ThorpSandra Van der AuweraBradley T. WebbTimothy B. BakerDanielle M. DickDmitriy DrichelLindsay A. FarrerNathan C. GaddisDana B. HancockJohn E. HokansonJouke-Jan HottengaEric O. JohnsonPamela A. MaddenMary L. MarazitaJesse A. MarksDaniel W. McNeilMichael NothnagelBryan C. QuachNancy L. SacconeNancy YA SeyRichard ShervaScott VriezeAlex WaldropGeorg WintererKendra YoungStephanie ZellersCathy L. BarrCsaba BartaKatharina BeyOscar J. BienvenuJulia BobergJonas Bybjerg-GrauholmAdrian CamarenaBeatriz CamarenaDanielle C. CathJames J. CrowleyAndrea DietrichPeter FalkaiThomas V. FernandezDaniel A. GellerMarco A. GradosErica L. GreenbergEdna GrünblattKristen HagenGregory L. HannaBjarne HansenGary A. HeimanPieter J. HoekstraDavid M. HougaardNorbert KathmannJulia KlawohnGerd KvaleNuria LanzagortaStephanie Le HellardFabio MacciardiBrion S. MaherIrene A. MalatyDavid Mataix-ColsCarol A. MathewsNicole CR McLaughlinEuripedes C. MiguelKirsten R. Müller-VahlHumberto NicoliniErika L. NurmiMichael S. OkunRaquel RabionetAlfredo RamirezRenata RizzoCristina Rodriguez-FontenlaPaul SandorElles de SchipperHarvey S. SingerEric A. StorchJeremy Veenstra-VanderWeeleMichael WagnerChristopher P. WalkerSøren B. AndersenLaura J. BierutChia-Yen ChenNikolaos P. DaskalakisSeth G. DisnerAnna R. DochertyNorah C. FeenyLana R. GrasserMagali HaasKelly M. HarringtonVictor M. HesselbrockMohammed H. IbrahimSeyma KatrinliNathan A. KimbrelJessica L. Maples-KellerJacquelyn L. MeyersJanitza L. Montalvo-OrtizCharles P. MorrisRobert H. PietrzakRenato PolimantiRichard J. RosenblumBarbara O. RothbaumBart PF RuttenSoraya SeedatAlicia K. SmithRalph E. TarterMuhammad AyubDominique CampionDavid CohenAngel ConsoliMarta Di FortiJohan G. ErikssonOlga YU FedorenkoRobert FreedmanRaul R. GainetdinovMarianna GiannitelliIna GieglingStephen J. GlattStephanie GodardOlivier GuillinAnnette M. HartmannSvetlana A. IvanovaAlexander O. KibitovBettina KonteClaudine Laurent-LevinsonAnastasia LevchenkoRobin MurrayMerete NordentoftCristiano NotoDiego QuattroneDan RujescuSafaa Saker-DelyeSIbylle G. SchwabFlorence ThibautJames TR WaltersThomas WergeDieter B. WildenauerArpana AgrawalDavid AA BarangerJason D. BoardmanJoseph M. BodenRyan BogdanKarhleen K. BucholzDoo-Sup ChoiSarah MC ColbertJoseph D. DeakNancy DiazgranadosAlexis C. EdwardsAlison M. GoateDavid GoldmanLaura M. HackKathleen Mullan HarrisSarah M. HartzCaroline HaywardJohn K. HewittChristian J. HopferVictor M. KarpyakKenneth S. KrauterEvgeny M. KrupitskySamuel KupermanJari LahtiMarius Lahti-PulkkinenDongbing LaiAlex P. MillerAbraham A. PalmerRohn H. PalmerJohn F. PearsonBernice PorjeszUlrich W. PreussDaniel M. RosenblumNorbert ScherbaumMichael VanyukovTamara L. WallRobbee WedowStanley H. WeissLeah WetherillNorbert WodarzHaitao ZhangHongyu ZhaoHang ZhouPeter ZillPhil H. LeeKenneth S. KendlerJordan W. Smoller + doi:10.1038/s41586-025-09820-3 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09820-3 + 2025-12-10 + Nature + 10.1038/s41586-025-09820-3 + https://www.nature.com/articles/s41586-025-09820-3 + + + + <![CDATA[An RNA splicing system that excises DNA transposons from animal mRNAs]]> + https://www.nature.com/articles/s41586-025-09853-8 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09853-8

A new type of mRNA splicing mechanism discovered in Caenorhabditis elegans that detects and removes inverted repeats also occurs in human cells, thereby providing another strategy to protect against the negative effects of transposable elements.]]> + + Long-Wen ZhaoChristopher NardoneCindy ChangJoao A. PauloStephen J. ElledgeScott Kennedy + doi:10.1038/s41586-025-09853-8 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09853-8 + 2025-12-10 + Nature + 10.1038/s41586-025-09853-8 + https://www.nature.com/articles/s41586-025-09853-8 + + + + <![CDATA[Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma]]> + https://www.nature.com/articles/s41586-025-09825-y + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09825-y

Lung adenocarcinomas bearing the ID2 mutational signature display increased LINE-1 retrotransposon activity, which contributes to their fast evolutionary dynamics and aggressive phenotype.]]> + + Tongwu ZhangWei ZhaoChristopher WirthMarcos Díaz-GayJinhu YinMonia CecatiFrancesca MarchegianiPhuc H. HoangCharles LeducMarina K. BaineWilliam D. TravisLynette M. ShollPhilippe JoubertJian SangJohn P. McElderryMichelle AntonyAlyssa KleinAzhar KhandekarCaleb HartmanJennifer RosenbaumFrank J. Colón-MatosMona MiraftabMonjoy SahaOlivia W. LeeKristine M. JonesNeil E. CaporasoMaria Pik WongKin Chung LeungChao Agnes HsiungChih-Yi ChenEric S. EdellJacobo Martínez SantamaríaMatthew B. SchabathSai S. YendamuriMarta ManczukJolanta LissowskaBeata ŚwiątkowskaAnush MukeriaOxana ShanginaDavid ZaridzeIvana HolcatovaDana MatesSasa MilosavljevicMilan SavicYohan BosséBonnie E. Gould RothbergDavid C. ChristianiValerie GaborieauPaul BrennanGeoffrey LiuPaul HofmanRobert HomerSoo-Ryum YangAngela C. PesatoriDario ConsonniLixing YangBin ZhuJianxin ShiKevin BrownNathaniel RothmanStephen J. ChanockLudmil B. AlexandrovJiyeon ChoiMaurizio CardelliQing LanMartin A. NowakDavid C. WedgeMaria Teresa Landi + doi:10.1038/s41586-025-09825-y + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09825-y + 2025-12-10 + Nature + 10.1038/s41586-025-09825-y + https://www.nature.com/articles/s41586-025-09825-y + + + + <![CDATA[Somatic evolution following cancer treatment in normal tissue]]> + https://www.nature.com/articles/s41586-025-09792-4 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09792-4

High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.]]> + + Oriol PichSophia WardAndrew RowanCristina Naceur-LombardelliOliver ShutkeverCarlos Martinez-RuizSiân HarriesSonya HesseyBabu NaiduJames D. BrentonJohn Le QuesneAnne ThomasCathy RichardsMatthew G. KrebsSamra TurajlicSanjay JogaiSimone ZaccariaDavid MooreCrispin T. HileyJohn Le QuesneKai-Keen ShiuJohn BridgewaterDaniel HochhauserMartin ForsterSiow Ming LeeTanya AhmadDionysis Papadatos-PastosSam JanesPeter Van LooKatey EnfieldAriana HuebnerSergio QuezadaStephan BeckTariq EnverDavid R. PearceMary FalzonRon SinclairZoe RhodesTeresa MarafiotiMiriam MitchisonMark LinchSebastian BrandnerSelvaraju VeeriahHeather ShawGerhardt AttardFaye GishenMaise Al-BakirNnenna KanuFrancisco Gimeno-ValienteEmilia L. LimJames ReadingBenny ChainAdrienne FlanaganEmma ColliverMihaela AngelovaJames BlackOlivia LucasWilliam HillWing Kin LiuAlexander FrankellRoberto SalgadoKristiana GrigoriadisTakahiro KarasakiAbigail BunkumSarah BenafifVittorio BarbèSupreet Kaur BolaOsvaldas VainauskasAnna WingateDaniel WetterskogA. M. Mahedi HasanStefano LiseGianmarco LeoneAnuradha JayaramConstantine AlifrangisUrsula McGovernKerstin TholSamuel GambleSeng Kuong UngPiotr PawlikRoberto VendraminJayant RaneAngela DwornikKerry BowlesJeanette KittelKerstin HaaseRija ZaidiAthanasia VargiamiouLucrezia PatrunoChristopher Aled ChamberlainWelles RobinsonIain McNeishNataly Ojeda MosqueraJiali LiuFelix O’FarrellChenelle MarcelJames LarkinLisa PickeringAndrew FurnessKate YoungWill DrakeKim EdmondsNikki HunterMary MangwendeLauren GrostateLavinia SpainScott ShepherdHaixi YanBenjamin ShumZayd TippuBrian HanleyCharlotte SpencerMax EmmerichCamille GerardEleanor CarlyleSteve HazellHardeep MudharChristina MessiouArash LatifoltojarAnnika FendlerFiona ByrneHusayn PallikondaIrene LobonAlexander CoultonAnne-Laure CattinDaqi DengHugang FengNadia YousafSanjay PopatCharlotte Milner-WattsEmma NyeAida MurraJustine KortewegLauren TerryJennifer BianoKema PeatEmma TurayPeter HillMarija MileticAnadil JavaidJennifer ThomasBakir KudicOrla McGowanDharmista RameshOznur SakaSinem ArslanLaura MarandinoReina AmmarGurneet KapurDilruba KabirDavid McMahonAlexius JohnFoteini KalofonouDebra JosephsSheeba IrshadJames SpicerAnna GreenRuby StewartNatasha WrightRuxandra MituDeborah EntingSarah RudmanSharmistha GhoshEleni KarapanagiotouElias PintusAndrew TuttNicola ThompsonRebecca FitzgeraldMerche Jimenez-LinanElena ProvenzanoAnna PatersonKieren AllinsonGrant D. StewartUltan McDermottTim MaughanOlaf AnsorgePeter CampbellPatricia RoxburghSioban FraserKevin BlythFiona BlackhallYvonne SummersPedro OliveiraCaroline DiveFabio GomesMat CarterDean FennellJacqui ShawClaire WilsonCharlotte PoileKudazyi H. KutywayoMaurice R. DungeyJens Claus HahneShobhit BaijalGerald LangmanCharlotte FerrisHollie BancroftAmy KerrGary MiddletonJoanne WebbSalma KadiriBernard OlisemekeRodelaine WilsonAya OsmanIan TomlinsonJudith CaveLuke NolanSamantha HoldenTania FernandesDave ChuterMairead McKenzieAllan HackshawAoife WalkerHayley BridgerRachel LeslieShivani PatelCharles SwantonMariam Jamal-HanjaniNicholas McGranahan + doi:10.1038/s41586-025-09792-4 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09792-4 + 2025-12-10 + Nature + 10.1038/s41586-025-09792-4 + https://www.nature.com/articles/s41586-025-09792-4 + + + + <![CDATA[Protected area management has significant spillover effects on vegetation]]> + https://www.nature.com/articles/s41586-025-09837-8 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09837-8

Analysis of effect sizes of vegetation spillovers from protected areas in Australia shows that 71% of over 3,063 analysed protected areas had a positive spillover effect, and that these effects covary with protected area management type.]]> + + Graeme S. Cumming + doi:10.1038/s41586-025-09837-8 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09837-8 + 2025-12-10 + Nature + 10.1038/s41586-025-09837-8 + https://www.nature.com/articles/s41586-025-09837-8 + + + + <![CDATA[Laser-based conversion electron Mössbauer spectroscopy of <sup>229</sup>ThO<sub>2</sub>]]> + https://www.nature.com/articles/s41586-025-09776-4 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09776-4

Laser-induced conversion electron Mössbauer spectroscopy, which detects electrons emitted by 229Th nuclei in a thin ThO2 sample excited by vacuum ultraviolet light, is demonstrated, opening the possibility of a conversion-electron-based nuclear clock.]]> + 229ThO2]]> + Ricky ElwellJames E. S. TerhuneChristian SchneiderHarry W. T. MorganHoang Bao Tran TanUdeshika C. PereraDaniel A. RehnMarisa C. AlfonsoLars von der WenseBenedict SeiferleKevin ScharlPeter G. ThirolfAndrei DereviankoEric R. Hudson + doi:10.1038/s41586-025-09776-4 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09776-4 + 2025-12-10 + Nature + 10.1038/s41586-025-09776-4 + https://www.nature.com/articles/s41586-025-09776-4 + + + + <![CDATA[Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity]]> + https://www.nature.com/articles/s41586-025-09828-9 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09828-9

The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophage–DC cross-priming and differentiation of protective memory T cells.]]> + + Xiaoying TianJiaqi LiuYuxi LiYupeng WangYuanhanyu LuoHuabin HeYang SheYan MaJingjin DingPing ZhouChao LiFeng Shao + doi:10.1038/s41586-025-09828-9 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09828-9 + 2025-12-10 + Nature + 10.1038/s41586-025-09828-9 + https://www.nature.com/articles/s41586-025-09828-9 + + + + <![CDATA[Causal modelling of gene effects from regulators to programs to traits]]> + https://www.nature.com/articles/s41586-025-09866-3 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09866-3

Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.]]> + + Mineto OtaJeffrey P. SpenceTony ZengEmma DannNikhil MilindAlexander MarsonJonathan K. Pritchard + doi:10.1038/s41586-025-09866-3 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09866-3 + 2025-12-10 + Nature + 10.1038/s41586-025-09866-3 + https://www.nature.com/articles/s41586-025-09866-3 + + + + <![CDATA[Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency]]> + https://www.nature.com/articles/s41586-025-09821-2 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09821-2

A forward genetic screen in Caenorhabditis elegans reveals that decreased levels of the ferredoxin FDX2 suppress the loss of frataxin in worms and in mice by relief of FDX2 inhibition of frataxin-stimulated NFS1 activity.]]> + + Joshua D. MeiselPallavi R. JoshiAmy N. SpelbringHong WangSandra M. WellnerPresli P. WiesenthalMaria MirandaJason G. McCoyDavid P. BarondeauGary RuvkunVamsi K. Mootha + doi:10.1038/s41586-025-09821-2 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09821-2 + 2025-12-10 + Nature + 10.1038/s41586-025-09821-2 + https://www.nature.com/articles/s41586-025-09821-2 + + + + <![CDATA[Gut micro-organisms associated with health, nutrition and dietary interventions]]> + https://www.nature.com/articles/s41586-025-09854-7 + + Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09854-7

Comprehensive large-scale studies of multi-national populations identified microbiome species consistently associated with favourable and unfavourable health markers, informing future studies of the human gut microbiome and its association with diet and cardiometabolic conditions.]]> + + Francesco AsnicarPaolo ManghiGloria FackelmannGabriel BaldanziElco BakkerLiviana RicciGianmarco PiccinnoElisa PiperniKatarina MladenovicFederica AmatiAlberto ArrèSajaysurya GaneshFrancesca GiordanoRichard DaviesJonathan WolfKate M. BerminghamSarah E. BerryTim D. SpectorNicola Segata + doi:10.1038/s41586-025-09854-7 + Nature, Published online: 2025-12-10; | doi:10.1038/s41586-025-09854-7 + 2025-12-10 + Nature + 10.1038/s41586-025-09854-7 + https://www.nature.com/articles/s41586-025-09854-7 + + + + <![CDATA[Pancreatic cancer is evasive. Is the nervous system the reason why?]]> + https://www.nature.com/articles/d41586-025-03943-3 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03943-3

A growing body of research suggests tumours rely on proteins and genes that are unique to the nervous system to persist in the body.]]> + + Laura Dattaro + doi:10.1038/d41586-025-03943-3 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03943-3 + 2025-12-10 + Nature + 10.1038/d41586-025-03943-3 + https://www.nature.com/articles/d41586-025-03943-3 + + + + <![CDATA[Six highlights from pancreatic cancer research]]> + https://www.nature.com/articles/d41586-025-03948-y + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03948-y

Unpacking risk factors, disease aggressiveness and other key work.]]> + + Laura Vargas-Parada + doi:10.1038/d41586-025-03948-y + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03948-y + 2025-12-10 + Nature + 10.1038/d41586-025-03948-y + https://www.nature.com/articles/d41586-025-03948-y + + + + <![CDATA[What would an AI university look like and how might it change education?]]> + https://www.nature.com/articles/d41586-025-03950-4 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03950-4

From lectures by avatars to entire qualifications, higher education centred around AI is just around the corner.]]> + + Jackson Ryan + doi:10.1038/d41586-025-03950-4 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03950-4 + 2025-12-10 + Nature + 10.1038/d41586-025-03950-4 + https://www.nature.com/articles/d41586-025-03950-4 + + + + <![CDATA[A breathalyser-style test for detecting pancreatic cancer]]> + https://www.nature.com/articles/d41586-025-03946-0 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03946-0

Surgeon George Hanna is developing a non-invasive test to catch one of the deadliest cancers before it’s too late.]]> + + Esme Hedley + doi:10.1038/d41586-025-03946-0 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03946-0 + 2025-12-10 + Nature + 10.1038/d41586-025-03946-0 + https://www.nature.com/articles/d41586-025-03946-0 + + <![CDATA[Is your brain tired? Researchers are discovering the roots of mental fatigue]]> https://www.nature.com/articles/d41586-025-03974-w @@ -192,6 +687,36 @@ https://www.nature.com/articles/d41586-025-03974-w + + <![CDATA[A giant catalogue of microscopic species across Denmark]]> + https://www.nature.com/articles/d41586-025-03819-6 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03819-6

The Microflora Danica project has catalogued the microbial diversity of environmental habitats across Denmark and established an improved taxonomic reference database. As well as providing a special record of nitrogen-oxidizing microorganisms, the data set serves as a national baseline for tracking future microbial responses to factors such as land-use change and global warming.]]> + + + doi:10.1038/d41586-025-03819-6 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03819-6 + 2025-12-10 + Nature + 10.1038/d41586-025-03819-6 + https://www.nature.com/articles/d41586-025-03819-6 + + + + <![CDATA[SOS: RNA-processing mechanism rescues genes from invasive DNA]]> + https://www.nature.com/articles/d41586-025-03734-w + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03734-w

Transposable elements can insert into genes, disrupting protein-coding potential. Researchers discover a mode of RNA processing, ‘SOS splicing’, that provides a quick fix.]]> + + René F. Ketting + doi:10.1038/d41586-025-03734-w + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03734-w + 2025-12-10 + Nature + 10.1038/d41586-025-03734-w + https://www.nature.com/articles/d41586-025-03734-w + + <![CDATA[But only just]]> https://www.nature.com/articles/d41586-025-04022-3 @@ -207,6 +732,21 @@ https://www.nature.com/articles/d41586-025-04022-3 + + <![CDATA[The pancreatic cancer models helping to drive innovation in the field]]> + https://www.nature.com/articles/d41586-025-03944-2 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03944-2

Cellular, animal and computational models of the disease are providing fresh insights into biology and treatment.]]> + + Rachel Nuwer + doi:10.1038/d41586-025-03944-2 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03944-2 + 2025-12-10 + Nature + 10.1038/d41586-025-03944-2 + https://www.nature.com/articles/d41586-025-03944-2 + + <![CDATA[China is leading the world on AI governance: other countries must engage]]> https://www.nature.com/articles/d41586-025-03972-y @@ -222,6 +762,171 @@ https://www.nature.com/articles/d41586-025-03972-y + + <![CDATA[Four young universities share their strategies for success]]> + https://www.nature.com/articles/d41586-025-03951-3 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03951-3

Nimble, responsive and collaborative, these institutions stand out in the Nature Index.]]> + + Xiaoying YouBenjamin Plackett + doi:10.1038/d41586-025-03951-3 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03951-3 + 2025-12-10 + Nature + 10.1038/d41586-025-03951-3 + https://www.nature.com/articles/d41586-025-03951-3 + + + + <![CDATA[A simple slipknot for precise force control]]> + https://www.nature.com/articles/d41586-025-03829-4 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03829-4

The tension of conventional surgical sutures can affect wound healing and is dependent on the surgeon’s experience. Imaging and simulations reveal that slipknots can reproducibly store and release force, enabling precise and consistent surgical knotting without the need for electronic sensors or specialized equipment.]]> + + + doi:10.1038/d41586-025-03829-4 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03829-4 + 2025-12-10 + Nature + 10.1038/d41586-025-03829-4 + https://www.nature.com/articles/d41586-025-03829-4 + + + + <![CDATA[Nuclear clocks could use electrical signals to keep time]]> + https://www.nature.com/articles/d41586-025-03732-y + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03732-y

The emission of photons by excited nuclei has been explored for timekeeping and sensing, but nuclear processes that eject electrons offer practical advantages.]]> + + Xiwen ZhangOlga Kocharovskaya + doi:10.1038/d41586-025-03732-y + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03732-y + 2025-12-10 + Nature + 10.1038/d41586-025-03732-y + https://www.nature.com/articles/d41586-025-03732-y + + + + <![CDATA[Huge genetic study reveals hidden links between psychiatric conditions]]> + https://www.nature.com/articles/d41586-025-04037-w + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-04037-w

Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants.]]> + + Max Kozlov + doi:10.1038/d41586-025-04037-w + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-04037-w + 2025-12-10 + Nature + 10.1038/d41586-025-04037-w + https://www.nature.com/articles/d41586-025-04037-w + + + + <![CDATA[Genetically engineered mosquitoes block development of circulating malaria strains]]> + https://www.nature.com/articles/d41586-025-03577-5 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03577-5

The genetic engineering of mosquitoes offers a potentially transformative, self-sustaining opportunity for malaria control and elimination in Africa. By rendering mosquitoes unable to transmit the malaria parasite, even when they bite humans, the technology provides a mosquito-based intervention to complement existing efforts.]]> + + + doi:10.1038/d41586-025-03577-5 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03577-5 + 2025-12-10 + Nature + 10.1038/d41586-025-03577-5 + https://www.nature.com/articles/d41586-025-03577-5 + + + + <![CDATA[Therapeutic vaccines can challenge pancreatic cancer before it takes hold]]> + https://www.nature.com/articles/d41586-025-03947-z + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03947-z

Specific protein targets and personalized vaccines have the potential to increase survival rates for the disease.]]> + + Anthony King + doi:10.1038/d41586-025-03947-z + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03947-z + 2025-12-10 + Nature + 10.1038/d41586-025-03947-z + https://www.nature.com/articles/d41586-025-03947-z + + + + <![CDATA[The brain’s speech centre responds to universal and specific features of language]]> + https://www.nature.com/articles/d41586-025-03827-6 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03827-6

More than 7,000 languages are spoken around the world, but the human brain becomes highly specialized to process speech in an individual’s own language. Recordings from human brains reveal the shared and language-specific neural mechanisms that arise in the superior temporal gyrus to achieve this feat.]]> + + + doi:10.1038/d41586-025-03827-6 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03827-6 + 2025-12-10 + Nature + 10.1038/d41586-025-03827-6 + https://www.nature.com/articles/d41586-025-03827-6 + + + + <![CDATA[Shared genetic risk in psychiatric disorders]]> + https://www.nature.com/articles/d41586-025-03728-8 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03728-8

Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed?]]> + + Abdel Abdellaoui + doi:10.1038/d41586-025-03728-8 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03728-8 + 2025-12-10 + Nature + 10.1038/d41586-025-03728-8 + https://www.nature.com/articles/d41586-025-03728-8 + + + + <![CDATA[Early detection could improve pancreatic cancer’s poor survival rates]]> + https://www.nature.com/articles/d41586-025-03945-1 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03945-1

The disease is often caught too late to affect a person’s prognosis — scientists are looking to change that.]]> + + Cassandra Willyard + doi:10.1038/d41586-025-03945-1 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03945-1 + 2025-12-10 + Nature + 10.1038/d41586-025-03945-1 + https://www.nature.com/articles/d41586-025-03945-1 + + + + <![CDATA[Oldest known evidence of the controlled ignition of fire]]> + https://www.nature.com/articles/d41586-025-03735-9 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03735-9

A 400,000-year-old site excavated in England reveals signs of deliberate fires made using the mineral iron pyrite to produce sparks.]]> + + Ségolène Vandevelde + doi:10.1038/d41586-025-03735-9 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03735-9 + 2025-12-10 + Nature + 10.1038/d41586-025-03735-9 + https://www.nature.com/articles/d41586-025-03735-9 + + + + <![CDATA[A guide to the Nature Index]]> + https://www.nature.com/articles/d41586-025-03952-2 + + Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03952-2

A description of the terminology and methodology used in this supplement, and a guide to the functionality that is available free online at natureindex.com.]]> + + + doi:10.1038/d41586-025-03952-2 + Nature, Published online: 2025-12-10; | doi:10.1038/d41586-025-03952-2 + 2025-12-10 + Nature + 10.1038/d41586-025-03952-2 + https://www.nature.com/articles/d41586-025-03952-2 + + <![CDATA[Don’t overlook the value of co-supervision in PhD training]]> https://www.nature.com/articles/d41586-025-03998-2 @@ -597,709 +1302,4 @@ https://www.nature.com/articles/d41586-025-03841-8 - - <![CDATA[Five years of COVID vaccines: how a breakthrough created a public-health crisis]]> - https://www.nature.com/articles/d41586-025-03992-8 - - Nature, Published online: 08 December 2025; doi:10.1038/d41586-025-03992-8

Physician and science communicator Kristen Panthagani talks about why public trust in vaccines has fallen since the COVID-19 pandemic.]]> - - Miryam NaddafFred Schwaller - doi:10.1038/d41586-025-03992-8 - Nature, Published online: 2025-12-08; | doi:10.1038/d41586-025-03992-8 - 2025-12-08 - Nature - 10.1038/d41586-025-03992-8 - https://www.nature.com/articles/d41586-025-03992-8 - - - - <![CDATA[These are a few of my favourite sounds: Books in brief]]> - https://www.nature.com/articles/d41586-025-03996-4 - - Nature, Published online: 05 December 2025; doi:10.1038/d41586-025-03996-4

Andrew Robinson reviews five of the best science picks.]]> - - Andrew Robinson - doi:10.1038/d41586-025-03996-4 - Nature, Published online: 2025-12-05; | doi:10.1038/d41586-025-03996-4 - 2025-12-05 - Nature - 10.1038/d41586-025-03996-4 - https://www.nature.com/articles/d41586-025-03996-4 - - - - <![CDATA[Hepatitis B vaccine guidance set to be rolled back for US babies: what the science says]]> - https://www.nature.com/articles/d41586-025-03937-1 - - Nature, Published online: 05 December 2025; doi:10.1038/d41586-025-03937-1

A panel of US vaccine advisers voted to rescind a recommendation that all newborns should receive a hepatitis B vaccine at birth.]]> - - Mariana LenharoHeidi Ledford - doi:10.1038/d41586-025-03937-1 - Nature, Published online: 2025-12-05; | doi:10.1038/d41586-025-03937-1 - 2025-12-05 - Nature - 10.1038/d41586-025-03937-1 - https://www.nature.com/articles/d41586-025-03937-1 - - - - <![CDATA[The Indian Ocean disaster is a climate tragedy — and needs more attention]]> - https://www.nature.com/articles/d41586-025-03973-x - - Nature, Published online: 05 December 2025; doi:10.1038/d41586-025-03973-x

A region unused to tropical cyclones has had three in a week. The world needs to ask why this happened, not look away.]]> - - Dyna Rochmyaningsih - doi:10.1038/d41586-025-03973-x - Nature, Published online: 2025-12-05; | doi:10.1038/d41586-025-03973-x - 2025-12-05 - Nature - 10.1038/d41586-025-03973-x - https://www.nature.com/articles/d41586-025-03973-x - - - - <![CDATA[AI is saving time and money in research — but at what cost?]]> - https://www.nature.com/articles/d41586-025-03936-2 - - Nature, Published online: 05 December 2025; doi:10.1038/d41586-025-03936-2

Artificial-intelligence tools are boosting researchers’ productivity, but some worry about the effect of a growing reliance on them.]]> - - Rachel Fieldhouse - doi:10.1038/d41586-025-03936-2 - Nature, Published online: 2025-12-05; | doi:10.1038/d41586-025-03936-2 - 2025-12-05 - Nature - 10.1038/d41586-025-03936-2 - https://www.nature.com/articles/d41586-025-03936-2 - - - - <![CDATA[Author Correction: Activity of caspase-8 determines plasticity between cell death pathways]]> - https://www.nature.com/articles/s41586-025-09980-2 - - Nature, Published online: 04 December 2025; doi:10.1038/s41586-025-09980-2

Author Correction: Activity of caspase-8 determines plasticity between cell death pathways]]> - - Kim NewtonKatherine E. WickliffeAllie MaltzmanDebra L. DuggerRohit RejaYue ZhangMerone Roose-GirmaZora ModrusanMeredith S. SagollaJoshua D. WebsterVishva M. Dixit - doi:10.1038/s41586-025-09980-2 - Nature, Published online: 2025-12-04; | doi:10.1038/s41586-025-09980-2 - 2025-12-04 - Nature - 10.1038/s41586-025-09980-2 - https://www.nature.com/articles/s41586-025-09980-2 - - - - <![CDATA[Persuading voters using human–artificial intelligence dialogues]]> - https://www.nature.com/articles/s41586-025-09771-9 - - Nature, Published online: 04 December 2025; doi:10.1038/s41586-025-09771-9

Human–artificial intelligence (AI) dialogues can meaningfully impact voters’ attitudes towards presidential candidates and policy, demonstrating the potential of conversational AI to influence political decision-making.]]> - - Hause LinGabriela CzarnekBenjamin LewisJoshua P. WhiteAdam J. BerinskyThomas CostelloGordon PennycookDavid G. Rand - doi:10.1038/s41586-025-09771-9 - Nature, Published online: 2025-12-04; | doi:10.1038/s41586-025-09771-9 - 2025-12-04 - Nature - 10.1038/s41586-025-09771-9 - https://www.nature.com/articles/s41586-025-09771-9 - - - - <![CDATA[Aluminium is crucial to vaccines — and safe. Why are US advisers debating it?]]> - https://www.nature.com/articles/d41586-025-03955-z - - Nature, Published online: 04 December 2025; doi:10.1038/d41586-025-03955-z

RFK Jr’s vaccine advisory panel will be discussing the inclusion of adjuvants in childhood vaccinations this week. Here’s what’s at stake.]]> - - Heidi Ledford - doi:10.1038/d41586-025-03955-z - Nature, Published online: 2025-12-04; | doi:10.1038/d41586-025-03955-z - 2025-12-04 - Nature - 10.1038/d41586-025-03955-z - https://www.nature.com/articles/d41586-025-03955-z - - - - <![CDATA[China’s scientific clout is growing as US influence wanes: the data show how]]> - https://www.nature.com/articles/d41586-025-03956-y - - Nature, Published online: 04 December 2025; doi:10.1038/d41586-025-03956-y

An analysis of international research collaborations reveals the growing dominance of Chinese science.]]> - - Jeff Tollefson - doi:10.1038/d41586-025-03956-y - Nature, Published online: 2025-12-04; | doi:10.1038/d41586-025-03956-y - 2025-12-04 - Nature - 10.1038/d41586-025-03956-y - https://www.nature.com/articles/d41586-025-03956-y - - - - <![CDATA[AI chatbots can sway voters with remarkable ease — is it time to worry?]]> - https://www.nature.com/articles/d41586-025-03975-9 - - Nature, Published online: 04 December 2025; doi:10.1038/d41586-025-03975-9

Experiments involving real-world voters show how talking to a chatbot can shape people’s political opinions.]]> - - Max Kozlov - doi:10.1038/d41586-025-03975-9 - Nature, Published online: 2025-12-04; | doi:10.1038/d41586-025-03975-9 - 2025-12-04 - Nature - 10.1038/d41586-025-03975-9 - https://www.nature.com/articles/d41586-025-03975-9 - - - - <![CDATA[DeepSeek’s self-correcting AI model aces tough maths proofs]]> - https://www.nature.com/articles/d41586-025-03959-9 - - Nature, Published online: 04 December 2025; doi:10.1038/d41586-025-03959-9

The mathematical reasoning model performed as well as humans at prestigious international mathematics competitions.]]> - - Mohana Basu - doi:10.1038/d41586-025-03959-9 - Nature, Published online: 2025-12-04; | doi:10.1038/d41586-025-03959-9 - 2025-12-04 - Nature - 10.1038/d41586-025-03959-9 - https://www.nature.com/articles/d41586-025-03959-9 - - - - <![CDATA[AI chatbots can persuade voters to change their minds]]> - https://www.nature.com/articles/d41586-025-03733-x - - Nature, Published online: 04 December 2025; doi:10.1038/d41586-025-03733-x

Conversations with AI can sway people’s political views. Concerningly, a chatbot’s facts are not always accurate, especially when it supports right-wing positions.]]> - - Chiara VargiuAlessandro Nai - doi:10.1038/d41586-025-03733-x - Nature, Published online: 2025-12-04; | doi:10.1038/d41586-025-03733-x - 2025-12-04 - Nature - 10.1038/d41586-025-03733-x - https://www.nature.com/articles/d41586-025-03733-x - - - - <![CDATA[Retraction Note: The economic commitment of climate change]]> - https://www.nature.com/articles/s41586-025-09726-0 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09726-0

Retraction Note: The economic commitment of climate change]]> - - Maximilian KotzAnders LevermannLeonie Wenz - doi:10.1038/s41586-025-09726-0 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09726-0 - 2025-12-03 - Nature - 10.1038/s41586-025-09726-0 - https://www.nature.com/articles/s41586-025-09726-0 - - - - <![CDATA[Author Correction: Seismic detection of a 600-km solid inner core in Mars]]> - https://www.nature.com/articles/s41586-025-09981-1 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09981-1

Author Correction: Seismic detection of a 600-km solid inner core in Mars]]> - - Huixing BiDaoyuan SunNingyu SunZhu MaoMingwei DaiDouglas Hemingway - doi:10.1038/s41586-025-09981-1 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09981-1 - 2025-12-03 - Nature - 10.1038/s41586-025-09981-1 - https://www.nature.com/articles/s41586-025-09981-1 - - - - <![CDATA[Author Correction: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis]]> - https://www.nature.com/articles/s41586-025-09979-9 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09979-9

Author Correction: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis]]> - - Kim NewtonKatherine E. WickliffeDebra L. DuggerAllie MaltzmanMerone Roose-GirmaMonika DohseLászló KőművesJoshua D. WebsterVishva M. Dixit - doi:10.1038/s41586-025-09979-9 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09979-9 - 2025-12-03 - Nature - 10.1038/s41586-025-09979-9 - https://www.nature.com/articles/s41586-025-09979-9 - - - - <![CDATA[Experimental vaccine prevents deadly allergic reactions in mice]]> - https://www.nature.com/articles/d41586-025-03960-2 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03960-2

Technology could offer longer protection against allergies than is possible with existing treatments.]]> - - Rachel Fieldhouse - doi:10.1038/d41586-025-03960-2 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03960-2 - 2025-12-03 - Nature - 10.1038/d41586-025-03960-2 - https://www.nature.com/articles/d41586-025-03960-2 - - - - <![CDATA[Growing cities face mounting challenges]]> - https://www.nature.com/articles/d41586-025-03925-5 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03925-5

Urban health and well-being is central to the world’s future prospects]]> - - Richard Hodson - doi:10.1038/d41586-025-03925-5 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03925-5 - 2025-12-03 - Nature - 10.1038/d41586-025-03925-5 - https://www.nature.com/articles/d41586-025-03925-5 - - - - <![CDATA[Photobombing satellites could ruin the night sky for space telescopes]]> - https://www.nature.com/articles/d41586-025-03968-8 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03968-8

Astronomical images could be blemished by bright streaks, if plans for huge numbers of satellites go ahead — plus, the damaging consequences of video call glitches.]]> - - Benjamin ThompsonNick Petrić Howe - doi:10.1038/d41586-025-03968-8 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03968-8 - 2025-12-03 - Nature - 10.1038/d41586-025-03968-8 - https://www.nature.com/articles/d41586-025-03968-8 - - - - <![CDATA[Computational design of metallohydrolases]]> - https://www.nature.com/articles/s41586-025-09746-w - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09746-w

A generative artificial intelligence-powered method enables de novo design of highly active enzymes based on information about the geometry of residues in the active site, without requiring protein backbone or sequence information.]]> - - Donghyo KimSeth M. WoodburyWoody AhernDoug TischerAlex KangEmily JoyceAsim K. BeraNikita HanikelSaman SalikeRohith KrishnaJason YimSamuel J. PellockAnna LaukoIndrek KalvetDonald HilvertDavid Baker - doi:10.1038/s41586-025-09746-w - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09746-w - 2025-12-03 - Nature - 10.1038/s41586-025-09746-w - https://www.nature.com/articles/s41586-025-09746-w - - - - <![CDATA[A place-based assessment of biodiversity intactness in sub-Saharan Africa]]> - https://www.nature.com/articles/s41586-025-09781-7 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09781-7

Regional, place-based biodiversity information is used to comprehensively map and quantify biodiversity intactness of sub-Saharan Africa to inform national and global sustainability policies and planning.]]> - - Hayley S. ClementsReinette BiggsAlta De VosEmmanuel Do Linh SanGareth P. HempsonBirthe LindenBryan MaritzAra MonadjemChevonne ReynoldsFrances SiebertNicola StevensMatthew ChildEnrico Di MininKaren J. EslerMaike HamannTy LoftBelinda ReyersOdirilwe SelomaneGeethen SinghAndrew L. Skowno - doi:10.1038/s41586-025-09781-7 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09781-7 - 2025-12-03 - Nature - 10.1038/s41586-025-09781-7 - https://www.nature.com/articles/s41586-025-09781-7 - - - - <![CDATA[Sterile-neutrino search based on 259 days of KATRIN data]]> - https://www.nature.com/articles/s41586-025-09739-9 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09739-9

The analysis of the energy spectrum of 36 million tritium β-decay electrons recorded in 259 measurement days within the last 40 eV below the endpoint challenges the Neutrino-4 claim.]]> - - H. AcharyaM. AkerD. BatzlerA. BeglarianJ. BeisenkötterM. BiassoniB. BieringerY. BiondiM. BöttcherB. BornscheinL. BornscheinM. CarminatiA. ChatrabhutiS. ChilingaryanD. Díaz BarreroB. A. DanielM. DescherO. DragounG. DrexlinF. EdzardsK. EitelE. EllingerR. EngelS. EnomotoL. FallböhmerA. FeldenC. FenglerC. FioriniJ. A. FormaggioC. ForstnerF. M. FränkleG. GagliardiK. GaudaA. S. GavinW. GilF. GlückR. GrössleT. HöhnK. HabibV. HannenL. HaßelmannK. HelbingH. HenkeS. HeynsR. HillerD. HillesheimerD. HinzA. JansenC. KöhlerK. KhosonthongkeeJ. KohpeißL. KöllenbergerA. KopmannN. KovačL. La CascioL. LaschingerT. LasserreJ. LauerT.-L. LeO. LebedaB. LehnertA. LokhovM. MachatschekA. MarstellerE. L. MartinK. McMichaelC. MelzerL. E. MettlerS. MertensS. MohantyJ. MostafaI. MüllerA. NavaH. NeumannS. NiemesI. NutiniA. OnillonD. S. ParnoM. PavanU. PinsookJ. PlößnerA. W. P. PoonJ. M. L. PoyatoF. PriesterJ. RálišM. RölligS. RamachandranR. G. H. RobertsonC. RodenbeckR. SackA. SaenzR. SalomonJ. SchürmannP. SchäferA.-K. SchützM. SchlösserL. SchlüterS. SchneidewindU. SchnurrA. SchwemmerA. SchwenckM. ŠefčíkJ. SeeyangnokD. SiegmannF. SimonJ. SongwadhanaF. SpanierD. SprengW. SreethawongM. SteidlJ. ŠtorekX. StriblM. SturmN. SuwonjandeeN. T. JeromeH. H. H. TelleT. ThümmlerL. A. ThorneN. TitovI. TkachevK. TrostK. UrbanD. VénosK. ValeriusS. WüstlingC. WeinheimerS. WelteJ. WendelC. WiesingerJ. F. WilkersonJ. WolfJ. WydraW. XuS. ZadorozhnyG. Zeller - doi:10.1038/s41586-025-09739-9 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09739-9 - 2025-12-03 - Nature - 10.1038/s41586-025-09739-9 - https://www.nature.com/articles/s41586-025-09739-9 - - - - <![CDATA[Whole-genome landscapes of 1,364 breast cancers]]> - https://www.nature.com/articles/s41586-025-09812-3 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09812-3

Whole-genome and transcriptome analysis of 1,364 cases of breast cancer from South Korea broadens our understanding of breast cancer biology and reveals genomic features that connect tumour biology with treatment responses and clinical outcomes.]]> - - Ryul KimJonghan YuJoonoh LimBrian Baek-Lok OhSeok Jin NamSeok Won KimJeong Eon LeeByung Joo ChaeJi-Yeon KimGa Eun ParkBong Joo KangPill Sun PaikSoo Yeon BaeChang Ik YoonYoung Joo LeeDooreh KimKabsoo ShinJi Eun LeeJun KangAhwon LeeErin Connolly-StrongSangmoon LeeBo Rahm LeeYuna LeeKi Jong YiYoung Oh KwonIn Hwan ChunJunggil ParkJihye KimChahyun ChoiJong Yeon ShinHyungjung LeeMinji KimHansol ParkIlecheon JeongBoram YiWon-Chul LeeJeong Seok LeeWoo Chan ParkSung Hun KimYoon-La ChoiJeongmin LeeYoung Seok JuYeon Hee Park - doi:10.1038/s41586-025-09812-3 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09812-3 - 2025-12-03 - Nature - 10.1038/s41586-025-09812-3 - https://www.nature.com/articles/s41586-025-09812-3 - - - - <![CDATA[Modelling late gastrulation in stem cell-derived monkey embryo models]]> - https://www.nature.com/articles/s41586-025-09831-0 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09831-0

An optimized 3D culture system enabled a stem cell-derived monkey blastoid to develop to day 25, recapitulating key events of primate late gastrula and demonstrating notable similarity to natural embryos.]]> - - Jie LiJie LiJing CaoShenShen ShangLiansheng ZhangFei GaoJiqiang FuHongyu ChenGuizhong CuiHaoyuan WuXiaolong WangAlfonso Martinez-AriasQiang SunZhen Liu - doi:10.1038/s41586-025-09831-0 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09831-0 - 2025-12-03 - Nature - 10.1038/s41586-025-09831-0 - https://www.nature.com/articles/s41586-025-09831-0 - - - - <![CDATA[Dated gene duplications elucidate the evolutionary assembly of eukaryotes]]> - https://www.nature.com/articles/s41586-025-09808-z - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09808-z

Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex archaea that already possessed an elaborated cytoskeleton, membrane trafficking, endomembrane, phagocytotic machinery and a nucleus.]]> - - Christopher J. KayAnja SpangGergely J. SzöllősiDavide PisaniTom A. WilliamsPhilip C. J. Donoghue - doi:10.1038/s41586-025-09808-z - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09808-z - 2025-12-03 - Nature - 10.1038/s41586-025-09808-z - https://www.nature.com/articles/s41586-025-09808-z - - - - <![CDATA[TSC tunes progenitor balance and upper-layer neuron generation in neocortex]]> - https://www.nature.com/articles/s41586-025-09810-5 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09810-5

The balance between radial progenitors and intermediate precursors to generate upper-layer neurons during the development and evolution of the cerebral cortex is mediated by members of the tuberous sclerosis complex.]]> - - Cristine R. CasingalNaoki NakagawaKeiko Yabuno-NakagawaCailyn MeyerSiling LiuVasiliki GkiniSu-Ji ChoMario SkaricaDan LiangJeremy M. SimonNana MatobaAhana MallickRubal SinglaJieun ParkChu-Wei HuangHailey WilsonJanice LeeH. Troy GhashghaeiGarret D. StuberOskari HeikinheimoTakashi NambaJason L. SteinE. S. Anton - doi:10.1038/s41586-025-09810-5 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09810-5 - 2025-12-03 - Nature - 10.1038/s41586-025-09810-5 - https://www.nature.com/articles/s41586-025-09810-5 - - - - <![CDATA[The Microflora Danica atlas of Danish environmental microbiomes]]> - https://www.nature.com/articles/s41586-025-09794-2 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09794-2

Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.]]> - - C. M. SingletonT. B. N. JensenF. DeloguK. S. KnudsenE. A. SørensenV. R. JørgensenS. M. KarstY. YangM. SereikaF. PetriglieriS. KnutssonS. M. DallR. H. KirkegaardJ. M. KristensenC. K. OvergaardB. J. WoodcroftD. R. SpethS. T. N. AroneyHenning C. ThomsenBent T. ChristensenLis W. de JongeAnne-Cathrine S. DanielsenCecilie HermansenMogens H. GreveRasmus EjrnæsThomas A. DavidsonSigne NormandUrs A. TreierBjarke MadsenAndreas SchrammIan P. G. MarshallAnn-Sofie DamKasper U. KjeldsenKai FinsterPhilip F. ThomsenEva E. SigsgaardMartin J. KlepkeMarie VestergårdErik AudeLene ThomsenCamilla LemmingRita HørfarterMarlene M. JensenTobias G. FrøslevLone GramPeter B. SvendsenMorten Dencker SchostagSanne KjellerupTorben L. SkovhusDitte A. SøborgKasper ReitzelJørgen F. PedersenAndrew GiguereInge S. PedersenMads SønderkærJes VollertsenFan LiuPeter RoslevNiels IversenKåre L. NielsenNadieh de JongeDan BruhnJeppe L. NielsenTorsten N. KristensenChenjing JiangMarta A. NierychloGiulia DottoriniM. WagnerM. K. D. DueholmP. H. NielsenM. Albertsen - doi:10.1038/s41586-025-09794-2 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09794-2 - 2025-12-03 - Nature - 10.1038/s41586-025-09794-2 - https://www.nature.com/articles/s41586-025-09794-2 - - - - <![CDATA[Determination of the spin and parity of all-charm tetraquarks]]> - https://www.nature.com/articles/s41586-025-09711-7 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09711-7

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.]]> - - A. HayrapetyanV. MakarenkoA. TumasyanW. AdamJ. W. AndrejkovicL. BenatoT. BergauerM. DragicevicC. GiordanoP. S. HussainM. JeitlerN. KrammerA. LiD. LikoM. MatthewmanI. MikulecJ. SchieckR. SchöfbeckD. SchwarzM. ShooshtariM. SonawaneW. WaltenbergerC.-E. WulzT. JanssenH. KwonD. Ocampo HenaoT. Van LaerP. Van MechelenJ. BierkensN. BreugelmansJ. D’HondtS. DansanaA. De MoorM. DelcourtF. HeyenY. HongP. KashkoS. LowetteI. MakarenkoD. MüllerJ. SongS. TavernierM. TytgatG. P. Van OnsemS. Van PutteD. VanneromB. BilinB. ClerbauxA. K. DasI. De BruynG. De LentdeckerH. EvardL. FavartP. GianneiosA. KhalilzadehF. A. KhanA. MalaraM. A. ShahzadL. ThomasM. Vanden BemdenC. Vander VeldeP. VanlaerF. ZhangM. De CoenD. DoburG. GokbulutJ. KnolleL. LambrechtD. MarckxK. SkovpenN. 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Rapidly growing satellite constellations pose a substantial threat to astronomical observations, with projections indicating that future space telescopes will have more than 96% of their exposures affected by satellite trails, necessitating urgent mitigation strategies.]]> - - Alejandro S. BorlaffPamela M. MarcumSteve B. Howell - doi:10.1038/s41586-025-09759-5 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09759-5 - 2025-12-03 - Nature - 10.1038/s41586-025-09759-5 - https://www.nature.com/articles/s41586-025-09759-5 - - - - <![CDATA[Computational enzyme design by catalytic motif scaffolding]]> - https://www.nature.com/articles/s41586-025-09747-9 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09747-9

A hybrid machine learning and atomistic modelling strategy enables one-shot design of efficient enzymes to catalyse diverse biological and non-biological chemical transformations.]]> - - Markus BraunAdrian TrippMorakot ChakatokSigrid KaltenbrunnerCelina FischerDavid StollAleksandar BijelicWael ElailyMassimo G. TotaroMelanie MoserShlomo Y. HochHorst LechnerFederico RossiMatteo AleottiMélanie HallGustav Oberdorfer - doi:10.1038/s41586-025-09747-9 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09747-9 - 2025-12-03 - Nature - 10.1038/s41586-025-09747-9 - https://www.nature.com/articles/s41586-025-09747-9 - - - - <![CDATA[<b>Built environment disparities are amplified during extreme weather recovery</b>]]> - https://www.nature.com/articles/s41586-025-09804-3 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09804-3

Higher-income neighbourhoods rebuild and improve after disasters while lower-income areas do not return to pre-disaster conditions.]]> - Built environment disparities are amplified during extreme weather recovery]]> - Tianyuan HuangChad ZanoccoZhecheng WangJackelyn HwangRam Rajagopal - doi:10.1038/s41586-025-09804-3 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09804-3 - 2025-12-03 - Nature - 10.1038/s41586-025-09804-3 - https://www.nature.com/articles/s41586-025-09804-3 - - - - <![CDATA[Video-call glitches trigger uncanniness and harm consequential life outcomes]]> - https://www.nature.com/articles/s41586-025-09823-0 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09823-0

Glitches in video calls can have a negative effect on the judgement of the people involved and correspond to worse outcomes in major areas of life such as job interviews and parole hearings.]]> - - Melanie S. BrucksJacqueline R. RifkinJeff S. Johnson - doi:10.1038/s41586-025-09823-0 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09823-0 - 2025-12-03 - Nature - 10.1038/s41586-025-09823-0 - https://www.nature.com/articles/s41586-025-09823-0 - - - - <![CDATA[Search for light sterile neutrinos with two neutrino beams at MicroBooNE]]> - https://www.nature.com/articles/s41586-025-09757-7 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09757-7

Data obtained from the MicroBooNE liquid-argon time projection chamber are used to exclude the single light sterile neutrino interpretation of the LSND and MiniBooNE anomalies at the 95% confidence level.]]> - - P. AbratenkoD. Andrade AldanaL. ArellanoJ. AsaadiA. AshkenaziS. BalasubramanianB. BallerA. BarnardG. BarrD. BarrowJ. BarrowV. BasqueJ. BatemanO. Benevides RodriguesS. BerkmanA. BhatM. BhattacharyaM. BishaiA. BlakeB. BogartT. BoltonM. B. BrunettiL. CamilleriD. CaratelliF. CavannaG. CeratiA. ChappellY. ChenJ. M. ConradM. ConveryL. Cooper-TroendleJ. I. Crespo-AnadónR. CrossM. Del TuttoS. R. DennisP. DetjeR. DiurbaZ. DjurcicK. DuffyS. DytmanB. EberlyP. EnglezosA. EreditatoJ. J. EvansC. FangB. T. FlemingW. ForemanD. FrancoA. P. FurmanskiF. GaoD. Garcia-GamezS. GardinerG. GeS. GollapinniE. GramelliniP. GreenH. GreenleeL. GuW. GuR. GuenetteP. GuzowskiL. HagamanM. D. HandleyO. HenC. HilgenbergG. A. Horton-SmithA. HussainB. IrwinM. S. IsmailC. JamesX. JiJ. H. JoR. A. JohnsonY.-J. JwaD. KalraG. KaragiorgiW. KetchumM. KirbyT. KobilarcikN. LaneJ.-Y. LiY. LiK. LinB. R. LittlejohnL. LiuW. C. LouisX. LuoT. MahmudC. MarianiD. MarsdenJ. MarshallN. MartinezD. A. Martinez CaicedoS. MartynenkoA. MastbaumI. MawbyN. McConkeyL. MelletJ. MendezJ. MicallefA. MoganT. MohayaiM. MooneyA. F. MoorC. D. MooreL. Mora LepinM. M. MoudgalyaS. MulleriababuD. NaplesA. Navrer-AgassonN. NayakM. Nebot-GuinotC. NguyenJ. NowakN. OzaO. PalamaraN. PallatV. PaoloneA. PapadopoulouV. PapavassiliouH. B. ParkinsonS. F. PateN. PatelZ. PavlovicE. PiasetzkyK. PletcherI. PophaleX. QianJ. L. RaafV. RadekaA. RafiqueM. Reggiani-GuzzoJ. Rodriguez RondonM. RosenbergM. Ross-LonerganI. SafaD. W. SchmitzA. SchukraftW. SeligmanM. H. ShaevitzR. SharankovaJ. ShiE. L. SniderM. SoderbergS. Söldner-RemboldJ. SpitzM. StancariJ. St. JohnT. StraussA. M. SzelcN. TaniuchiK. TeraoC. ThorpeD. TorbunovD. TotaniM. ToupsA. TrettinY.-T. TsaiJ. TylerM. A. UchidaT. UsherB. VirenJ. WangM. WeberH. WeiA. J. WhiteS. WolbersT. WongjiradK. WresiloW. WuE. YandelT. YangL. E. YatesH. W. YuG. P. ZellerJ. ZennamoC. Zhang - doi:10.1038/s41586-025-09757-7 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09757-7 - 2025-12-03 - Nature - 10.1038/s41586-025-09757-7 - https://www.nature.com/articles/s41586-025-09757-7 - - - - <![CDATA[Viral RNA blocks circularization to evade host codon usage control]]> - https://www.nature.com/articles/s41586-025-09809-y - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09809-y

Rather than adapting to the codon usage of their host, viruses use viral 5′ untranslated regions to initiate translation, which allows them to produce viral proteins in host cells efficiently despite poor codon usage profiles.]]> - - Huan LiuJiabin DuanRenu GargPancheng XieYi Liu - doi:10.1038/s41586-025-09809-y - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09809-y - 2025-12-03 - Nature - 10.1038/s41586-025-09809-y - https://www.nature.com/articles/s41586-025-09809-y - - - - <![CDATA[<i>Homo sapiens</i>-specific evolution unveiled by ancient southern African genomes]]> - https://www.nature.com/articles/s41586-025-09811-4 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09811-4

The genomes of 28 ancient southern African individuals dated to between 10,200 and 150 years before present offer insights into the evolution of Homo sapiens.]]> - Homo sapiens-specific evolution unveiled by ancient southern African genomes]]> - Mattias JakobssonCarolina BernhardssonJames McKennaNina HollfelderMario VicenteHanna EdlundAlexandra CoutinhoPer SjödinJames BrinkBernhard ZipfelHelena MalmströmMarlize LombardCarina M. Schlebusch - doi:10.1038/s41586-025-09811-4 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09811-4 - 2025-12-03 - Nature - 10.1038/s41586-025-09811-4 - https://www.nature.com/articles/s41586-025-09811-4 - - - - <![CDATA[Architecture of the neutrophil compartment]]> - https://www.nature.com/articles/s41586-025-09807-0 - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09807-0

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.]]> - - Daniela Cerezo-WallisAndrea Rubio-PonceMathis RichterEmanuele PitinoImmanuel KwokGiovanni MartelettoAna Cristina Guanolema-CobaChangming ShihRun-Kai HuangAna MoragaNatalia Borbaran BravoSamuel DoréSergio CallejasDavid G. AragonésDaniel Jiménez-CarreteroDaniel MartinSamuel OvadiaTommaso VicanoloGeorgiana CrainiciucJon SiciliaTong DengAnjelica MartinJing ZhangMaria Isabel CuarteroDiego Moncada GiraldoAlicia Garcia-CulebrasAlejandra Aroca-CrevillenSandra Martín-SalamancaCarlos TorrojaMax RuizIrene RuanoMelissa S. F. NgJian HouYou WangMing ZhangJun PuAna HerruzoDavid Chang van OordtSeokyoon ChangAlexander E. DownieFei ChenAndrea L. GrahamWilliam C. GausePierre O. FisetJonathan D. SpicerHolger HeynMaria A. ZuriagaJuan A. BernalIrina A. UdalovaMaria A. MoroKatrien de BockAna DopazoJose J. FusterFátima Sánchez-CaboJuan C. NietoGabriel F. CalvoJulia SkokowaOliver SoehnleinDaniela F. QuailLogan A. WalshLai Guan NgAndrés HidalgoIván Ballesteros - doi:10.1038/s41586-025-09807-0 - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09807-0 - 2025-12-03 - Nature - 10.1038/s41586-025-09807-0 - https://www.nature.com/articles/s41586-025-09807-0 - - - - <![CDATA[Decay of driver mutations shapes the landscape of intestinal transformation]]> - https://www.nature.com/articles/s41586-025-09762-w - - Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09762-w

The order in which driver mutations of colorectal cancer occur in intestinal epithelium can determine whether clones are positively or negatively selected and can shape subsequent tumour development.]]> - - Filipe C. LourençoIannish D. SadienKim WongSam AdlerAshley SawleLeonor Schubert SantanaLee HazelwoodGiada GiavaraAnna M. NicholsonMatthew D. EldridgeNoori MakaGerard LynchStephen T. McSorleyJoanne EdwardsRichard KempDavid J. AdamsDouglas J. Winton - doi:10.1038/s41586-025-09762-w - Nature, Published online: 2025-12-03; | doi:10.1038/s41586-025-09762-w - 2025-12-03 - Nature - 10.1038/s41586-025-09762-w - https://www.nature.com/articles/s41586-025-09762-w - - - - <![CDATA[Darleane C. Hoffman obituary: chemist who expanded the periodic table]]> - https://www.nature.com/articles/d41586-025-03969-7 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03969-7

Her experiments on the heaviest elements deepened our understanding of radioactivity.]]> - - Dawn Shaughnessy - doi:10.1038/d41586-025-03969-7 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03969-7 - 2025-12-03 - Nature - 10.1038/d41586-025-03969-7 - https://www.nature.com/articles/d41586-025-03969-7 - - - - <![CDATA[‘Anyone hired a student before?’ How a group of novice lab leaders are supporting each other]]> - https://www.nature.com/articles/d41586-025-03486-7 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03486-7

By creating a network of early-career principal investigators, my colleagues and I have enacted change and battled bureaucracy.]]> - - Gianvito Scaringi - doi:10.1038/d41586-025-03486-7 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03486-7 - 2025-12-03 - Nature - 10.1038/d41586-025-03486-7 - https://www.nature.com/articles/d41586-025-03486-7 - - - - <![CDATA[Data drive city transportation forwards]]> - https://www.nature.com/articles/d41586-025-03931-7 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03931-7

‘Smart cities’ seek to maximize connectivity to improve urban mobility.]]> - - Neil Savage - doi:10.1038/d41586-025-03931-7 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03931-7 - 2025-12-03 - Nature - 10.1038/d41586-025-03931-7 - https://www.nature.com/articles/d41586-025-03931-7 - - - - <![CDATA[Cities are embracing nature for flood defence]]> - https://www.nature.com/articles/d41586-025-03927-3 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03927-3

As losses owing to flooding rise, some urban centres are ditching the concrete and making space for natural wetlands.]]> - - Erica Gies - doi:10.1038/d41586-025-03927-3 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03927-3 - 2025-12-03 - Nature - 10.1038/d41586-025-03927-3 - https://www.nature.com/articles/d41586-025-03927-3 - - - - <![CDATA[A glasses-free 3D display uses AI to direct images straight to the viewer’s eyes]]> - https://www.nature.com/articles/d41586-025-03828-5 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03828-5

For decades, creating a large, glasses-free 3D display that looks like a real window has been a challenge because screens broadcast image information wastefully. Artificial intelligence has now been used to focus light only on the viewer’s eyes, delivering a seamless 3D experience using a low-cost display the size of a standard computer monitor.]]> - - - doi:10.1038/d41586-025-03828-5 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03828-5 - 2025-12-03 - Nature - 10.1038/d41586-025-03828-5 - https://www.nature.com/articles/d41586-025-03828-5 - - - - <![CDATA[Primate embryo model leaps across developmental boundaries]]> - https://www.nature.com/articles/d41586-025-03729-7 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03729-7

A stem-cell-based monkey embryo model that self-organizes into a comprehensive body plan could lead the way to more-sophisticated models of early human development.]]> - - Xiangyu KongThorold W. Theunissen - doi:10.1038/d41586-025-03729-7 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03729-7 - 2025-12-03 - Nature - 10.1038/d41586-025-03729-7 - https://www.nature.com/articles/d41586-025-03729-7 - - - - <![CDATA[Order in which cancer-driving mutations occur affects the chance of tumour development]]> - https://www.nature.com/articles/d41586-025-03748-4 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03748-4

What happens to the thousands of intestinal cells that have tumour-initiating DNA mutations? A study in mouse models shows that most are eliminated by strong negative selection, but those that survive create a more-permissive environment for subsequent mutations, opening up routes for cancer to develop.]]> - - - doi:10.1038/d41586-025-03748-4 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03748-4 - 2025-12-03 - Nature - 10.1038/d41586-025-03748-4 - https://www.nature.com/articles/d41586-025-03748-4 - - - - <![CDATA[Satellite swarms set to photobomb more than 95% of some telescopes’ images]]> - https://www.nature.com/articles/d41586-025-03953-1 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03953-1

Planned megaconstellations would contaminate the view of the cosmos of four orbiting telescopes.]]> - - Jenna Ahart - doi:10.1038/d41586-025-03953-1 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03953-1 - 2025-12-03 - Nature - 10.1038/d41586-025-03953-1 - https://www.nature.com/articles/d41586-025-03953-1 - - - - <![CDATA[China accounts for more than half of leading output in the applied sciences]]> - https://www.nature.com/articles/d41586-025-03715-z - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03715-z

The first Nature Index table on the field shows how research in the East is focused on industrial strategy.]]> - - Benjamin Plackett - doi:10.1038/d41586-025-03715-z - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03715-z - 2025-12-03 - Nature - 10.1038/d41586-025-03715-z - https://www.nature.com/articles/d41586-025-03715-z - - - - <![CDATA[A bothy among the stars]]> - https://www.nature.com/articles/d41586-025-03784-0 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03784-0

Just passing through.]]> - - M. J. Pettit - doi:10.1038/d41586-025-03784-0 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03784-0 - 2025-12-03 - Nature - 10.1038/d41586-025-03784-0 - https://www.nature.com/articles/d41586-025-03784-0 - - - - <![CDATA[Geothermal networks let cities warm and cool as one]]> - https://www.nature.com/articles/d41586-025-03932-6 - - Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03932-6

An upgrade to district heating systems brings greater flexibility and efficiency, and is giving gas companies a renewable future.]]> - - Peter Fairley - doi:10.1038/d41586-025-03932-6 - Nature, Published online: 2025-12-03; | doi:10.1038/d41586-025-03932-6 - 2025-12-03 - Nature - 10.1038/d41586-025-03932-6 - https://www.nature.com/articles/d41586-025-03932-6 - -