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{
  "cohort": {
    "n_genomes": 1200,
    "n_defense_subtypes": 236,
    "n_lineage_clusters": 184,
    "median_cluster_size": 2.0,
    "mean_chromosomal_systems": 12.339166666666667,
    "sd_chromosomal_systems": 4.997579344598298,
    "crispr_columns_found": [
      "CAS_Class1-Subtype-I-C",
      "CAS_Class1-Subtype-I-E",
      "CAS_Class1-Subtype-I-F",
      "CAS_Class1-Type-I",
      "Rst_HelicaseDUF2290"
    ],
    "frac_genomes_with_crispr": 0.5358333333333334,
    "n_exposure_covariates": 21
  },
  "testA_all_defense_load": {
    "partial_r2": 0.06686762998031304,
    "null_mean_r2": 0.022745599413750803,
    "partial_r2_excess": 0.044122030566562234,
    "pvalue": 0.0004997501249375312,
    "n": 1200,
    "n_covariates_used": 21
  },
  "testA_crispr_only": {
    "partial_r2": 0.059025287159522044,
    "null_mean_r2": 0.02420408368577469,
    "partial_r2_excess": 0.034821203473747356,
    "pvalue": 0.0004997501249375312,
    "n": 1200,
    "n_covariates_used": 21
  },
  "testB_load_vs_extrachrom_len": {
    "spearman": 0.15346876727421646,
    "pvalue": 9.169772191035603e-08,
    "n": 1200
  },
  "testB_load_vs_extrachrom_systems": {
    "spearman": 0.08176611321456927,
    "pvalue": 0.004593249117499305,
    "n": 1200
  },
  "testB_crispr_vs_extrachrom_len": {
    "spearman": -0.08849996099142415,
    "pvalue": 0.002150958655249886,
    "n": 1200
  },
  "per_system": {
    "n_tested": 116,
    "n_significant_p05_uncorrected": 73,
    "n_expected_by_chance_p05": 5.800000000000001,
    "n_significant_BH_q10": 79,
    "frac_significant_BH_q10": 0.6810344827586207,
    "median_partial_r2": 0.049194222796417164,
    "max_partial_r2": 0.3668275957603121,
    "worst_systems": [
      {
        "system": "BREX_II",
        "partial_r2": 0.3668275957603121,
        "pvalue": 0.0024937655860349127,
        "pvalue_bh": 0.0072319201995012464
      },
      {
        "system": "Rst_3HP",
        "partial_r2": 0.32120304394733223,
        "pvalue": 0.0024937655860349127,
        "pvalue_bh": 0.0072319201995012464
      },
      {
        "system": "DS-38",
        "partial_r2": 0.3204451806382036,
        "pvalue": 0.0024937655860349127,
        "pvalue_bh": 0.0072319201995012464
      },
      {
        "system": "pAgo_S2B",
        "partial_r2": 0.2157603084681764,
        "pvalue": 0.0024937655860349127,
        "pvalue_bh": 0.0072319201995012464
      },
      {
        "system": "BstA",
        "partial_r2": 0.17701550672550082,
        "pvalue": 0.0024937655860349127,
        "pvalue_bh": 0.0072319201995012464
      },
      {
        "system": "RnlAB",
        "partial_r2": 0.15109916332945839,
        "pvalue": 0.004987531172069825,
        "pvalue_bh": 0.012309651403406376
      }
    ]
  }
}