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A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy.,1
We present the case of a nine-year-old boy with hypoplastic left heart syndrome and immune thrombocytopenic purpura who subsequently developed pneumatosis intestinails with a benign clinical examination.,0
Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.,1
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
"The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.",1
"The possibility that the underlying disease or other chemotherapeutic agents may increase the risk of pulmonary toxicity can, however, be discussed.",0
EGFR-targeted therapy and related skin toxicity.,0
"As more chemotherapy pumps are implanted, undoubtedly, new and unusual complications will occur.",0
A spectrum of diseases.,0
A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim.,1
"Although uncommon, an intact anterior vetreous face against the corneal endothelium is possible when a wide opening has been made in the posterior capsule and the underlying vitreous face remains intact.",0
"After phakoemulsification, visual acuity improved to 20/50.",0
His seizures were controlled by 150mg/day of phenytoin in combination with primidone.,0
This study examines if gadolinium can be removed by frequent exchanges by peritoneal dialysis (PD).,0
"Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.",1
"Antiepileptic drug hypersensitivity syndrome consists of fever, rash, and internal organ involvement and usually occurs within the first 2 months of initiation of therapy.",0
"Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.",1
Liver dysfunction in ovarian hyperstimulation syndrome.,0
"Although fluoxetine-induced headache occurred in one patient, the other five reported no side effects at the doses used.",1
"CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.",1
"Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.",1
"Two cases were associated with the development of acute renal failure, whereas the third patient had pre-existing renal impairment.",0
A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa.,1
The aim of this article is to report weight loss in patients with schizophrenia after switching from olanzapine standard oral tablet (SOT) to olanzapine orally disintegrating tablets (ODT).,0
"Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.",1
Proteinuria level decreased to 2.80 g per day two weeks after temsirolimus withdrawal.,0
The duration of the pauses were equal or almost equal to one short plus one long P-P interval or to twice the basic sinus cycle.,0
"In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.",1
"After more than 18 years after cessation of the drug, most tests showed a further deterioration, including best-corrected visual acuity (RE: 0.1; LE: 0.7).",0
Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.,1
"We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.",1
Hydroxyurea associated with concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas in an elderly subject.,1
The aim of this study was to describe the occurrence of acute coronary syndromes in 3 cases of rituximab infusions.,1
"The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.",1
"However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.",1
Management of suspected neuroleptic malignant syndrome.,0
2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.,1
"On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.",1
"Apparently, the subacromial injection penetrated the anterior half of the supraspinatus tendon, causing a transient effect and signal change.",0
"Symptoms and signs of augmentation were related to low plasma levodopa levels, abating 75 minutes after oral levodopa administration and reappearing after 3 hours, closely mirroring the rapid rise and fall of plasma levodopa concentration.",1
"CONCLUSIONS: This observation of ""on-off"" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent.",1
"CONCLUSIONS: This phenomenon of sudden vitritis after KPro, with few other symptoms and with complete recovery, would be uncharacteristic of a bacterial endophthalmitis.",0
CONCLUSION: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.,1
We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.,1
"The incidence of pulmonary nodules after cardiac transplantation is not uncommon, and prompt diagnostic procedures are necessary to minimize disease-related morbidity and mortality.",0
A trial of combination chemotherapy using mitoxantrone-cyclophosphamide was started in 1983.,0
"Dosage varied widely, but as little as 0.1 mg caused significant signs and symptoms.",0
STUDY DESIGN: A case report is presented.,0
"In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.",1
"A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.",1
Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.,1
Its duration of action is brief and serious adverse effects have not been reported.,0
"We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.",1
Prompt treatment with intravenous antibiotics usually leads to full recovery.,0
"Although drug-induced allergic nephritis (DIAN) is one of the most common problems seen by nephrologists, its true frequency is probably underestimated.",0
OBJECTIVE: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus.,1
"Specifically, the complication of enzyme-induced hyperglycemia may be seen more frequently after exposure to the E. coli product.",0
"Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.",1
"The patient failed to respond to treatment with a conventional dosage of a lipid formulation of amphotericin B (lifoAmB; 5 mg/kg/day) given alone or in combination with itraconazole, and he responded only to an aggressive strategy that included a very high dosage of lifoAmB (15 mg/kg/day) given in combination with itraconazole as well as a rapid reduction in immunosuppression.",0
"A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.",1
A self-expanding metallic stent (Wallstent) was used to relieve obstruction of the common bile duct in a young male with a desmoplastic small cell tumor of the abdomen.,0
Extended-release tolterodine 4 mg/day was then prescribed to manage overactive bladder.,0
Neuroleptic malignant syndrome (NMS) is a potentially life-threatening adverse effect of antipsychotic agents.,0
Right internal carotid artery occlusion during intravenous thrombolysis for left middle cerebral artery occlusion.,0
"Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.",1
Methimazole-associated cholestatic liver injury: case report and brief literature review.,1
"CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.",1
It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.,1
OBJECTIVES: To present a very rare case of orally ingested sex hormone pills inducing nondurally attached meningioma in the lumbosacral region.,0
Divalproex sodium-induced eosinophilic pleural effusion.,1
"The patient developed severe hepatitis after chemotherapy and, despite achieving complete remission of the malignancy, died of hepatic failure.",0
Acute renal failure should be recognized as a potential complication of suramin treatment.,1
"""B"" was an 11-year-old girl with mild mental retardation and aggression who was treated with risperidone 1 mg per day.",0
OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.,1
We report a patient with psoriasis and HCL who was treated for 1 week with continuous intravenous infusion of 2-CdA for recurring HCL.,0
We report the first case of hairy cell leukemia occurring after cardiac transplantation.,0
Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia.,1
"We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.",1
Thus cabergoline may cause similar pleuropulmonary abnormalities to bromocriptine.,1
The mechanism of the reaction and guidelines for subsequent use of cyclosporine are not well defined.,0
The onset and duration of symptoms correlated directly to drug ingestion.,0
METHODS: A 70-year-old woman with bilateral normal tension glaucoma was treated with topical brimonidine and followed in an outpatient setting.,0
DISCUSSION: The occurrence of priapism in our patient was related to zuclopenthixol.,1
The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.,1
Clioquinol intoxication occurring in the treatment of acrodermatitis enteropathica with reference to SMON outside of Japan.,0
Lorazepam 2 mg was given with significant improvement.,0
"Thus, ultrasound may prevent inadvertent placement of the needle into these structures as might happen with either the blind technique or fluoroscopic technique.",0
S-1 could be used as palliative treatment in patients with recurrent/metastatic head and neck cancer.,0
"We present a case of an elderly patient with systemic lupus erythematosus diagnosed more than 40 years ago, who suffered from recurrent fractures and attendant complications despite a bone mineral density (BMD) score in the osteopenic range and treatment with bisphosphonates.",0
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
"We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy given intrathecally.",1
One not so well documented consequence of this treatment is avascular necrosis or osteonecrosis of the underlying bone.,0
CONCLUSIONS: The pathogenesis of methotrexate-induced papular eruption in collagen vascular diseases may suggest cutaneous small-vessel vasculitis.,1
"OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.",1
"After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.",1
"Renal biopsy demonstrated minimal glomerular changes with fusion of podocytes, tubular necrosis with regeneration of tubular epithelial cells, interstitial edema with focal interstitial fibrosis, and interstitial infiltration with neutrophils, eosinophils, plasma cells and mononuclear cells.",0
"In India, traditional therapy with herbal preparation (Ayurvedic medicine) is not uncommon.",0
Acyclovir neurotoxicity: clinical experience and review of the literature.,1
"In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.",1
This is the first report of a chronic myeloproliferative disorder following successful treatment of hairy cell leukemia.,0
RESULTS: A clinical diagnosis of fixed drug eruption owing to use of the PDE5 inhibitor tadalafil (Cialis) was made.,1
"After six weeks of therapy, clinical symptoms had greatly improved and intercellular antibody levels had decreased from a titer of 5,120 to 160.",0
"First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.",1
"On the 3rd day, an inferior vena cava (IVC) filter was placed with a heparin flush, after which massive IVC thrombosis developed.",1
"Perhaps rashes during infectious mononucleosis in association with other antibiotics are actually more common, but just not recognized.",0
There are no known deleterious effects on male fertility and on long-term teratogenic effect of isotretinoin.,0
Corynebacterium Group JK pathogen in cerebrospinal fluid shunt infection.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
BACKGROUND: This is the first communication of a fatal spontaneous spinal epidural hematoma following thrombolysis.,0
CONCLUSIONS: Imiquimod is a new and novel treatment option for cutaneous malignancies.,0
"Of the five that were treated with toxin, four showed complete resolution of symptoms after a course of treatment.",0
The crucial factors contributing to the deterioration of both patients in the two cases presented were the concentration of phenytoin manually infused and the possibility that their high-risk status made them poor candidates for manual intravenous phenytoin.,0
Both renal allografts had to be removed because of renal artery rupture secondary to Candida albicans infection.,0
Severe hepatocellular dysfunction following cyproterone acetate therapy.,1
A woman developed delusional parasitosis when taking phenelzine.,1
The successful use of streptokinase therapy in a child with chronic thrombosis of a prosthetic valve (Carbomedics) in the tricuspid position is presented.,0
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease.,0
The medical examiner's report indicated death caused by fluoxetine toxicity.,1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
Medical misadventure = human tragedy.,0
Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma.,1
"PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.",1
Platinum agents and secondary myeloid leukaemia: two cases treated only with platinum-based drugs.,0
"However, this class of drugs can lead to adverse effects on other organs.",0
"Because of the potential severity of this interaction, close monitoring of INR and warfarin dosage adjustment is recommended in patients receiving warfarin along with levamisole and 5-FU.",0
"Four years after achieving CR, she developed complicated life-threatening pulmonary infections with methicillin-resistant Staphylococcus epidermidis and Aspergillus niger during outpatient care.",0
A 1-month-old infant suffered cardiac arrest shortly after presentation to the emergency department.,0
"Arterial hypotension, which improved with inotropic agents, was the only complication that seemed related to the inhaled anaesthetic.",0
Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx.,0
"A 3-year-old, 10.9-kg girl was admitted to the pediatric intensive care unit with the diagnosis of dilated cardiomyopathy and acute decompensated heart failure.",0
Adenomyosis is an important cause of menorrhagia.,0
"Our patient, diagnosed with persistent ovarian carcinoma, had a peritoneal Tenckoff catheter placed for chemotherapy.",0
We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.,1
"At retest visits respectively 18, 19 and 20 years after cessation of hydroxychloroquine, a multifocal electroretinogram was performed in combination with colour vision tests and contrast sensitivity measurements.",0
"We suggest the use of esmolol for treatment of dysrhythmias secondary to caffeine toxicity; to the best of our knowledge, the use of esmolol has not been reported for this purpose.",0
"Hence, measures to avoid ischemic optic neuropathy have priority.",0
They also suggest that liver enzymes should be monitored during treatment with riluzole.,0
"Electrical, chemical, and thermal agents are the main causative agents of these burns.",0
"Fluorescein angiogram showed presence of venous collaterals, but the pattern of the edema was atypical; optical coherence tomography (OCT) and indocyanine green angiography (ICG) were used to confirm the diagnosis of CNV.",0
We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.,1
A 56-yr-old white female administered corticosteroids presented with left ear pain and facial swelling due to cervical subcutaneous emphysema from a diverticular perforation of the sigmoid colon.,0
"The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.",1
"Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.",1
"However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.",1
The association of phenothiazine overdose and respiratory distress syndrome merits consideration.,1
"The patient underwent an elective termination of an intrauterine pregnancy and subsequently was diagnosed with a pulmonary embolus, which delayed the diagnosis of her ruptured ectopic pregnancy.",0
Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.,1
These findings suggest that the arterial vasoconstriction decreased the integrity of the intestinal mucosal barrier and permitted the transmural migration of enteric organisms from the lumen of the bowel into the ascites-filled peritoneal cavity.,0
"CONCLUSIONS: Because of its structural similarity to the other vinca alkaloids, vinorelbine is believed to be responsible for SIADH in our patient.",1
"Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.",1
"He presented symptoms of fever, skin lesions consisting of multiple vesiculopapular rashes, pruritic maculae and bullae, and mucosal involvement of the eyes, lips, oral cavity, and anorectal junction.",0
"However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.",1
Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.,1
We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.,1
"A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.",1
The second patient developed both autoimmune thyroid disease and a refractory pre-patellar bursitis after 50 months of IFN-beta therapy.,1
Gold-induced pneumonitis.,1
"INVESTIGATIONS: Blood tests, peripheral blood smear, bone-marrow biopsy and aspirate, Holter electrocardiogram.",0
Clofazimine induced nail changes.,1
CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.,1
Gangrene of the fingertips after bleomycin and methotrexate.,1
"The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome.",1
"To our knowledge, this is the first report of insulin-induced lipohypertrophy with detailed histological examinations.",1
Herein we present a case of adenomyosis in the broad ligament with unusual gross features.,0
"Prompt diagnosis using histology, serology, and PCR analysis allows prompt introduction of therapy and an improved prognosis.",0
Immediately after application of 80 mg pyridoxine fits stopped and the EEG was without seizure activity.,0
"These observations, although based on a single case, provide strong evidence that testosterone may exert powerful antidepressant action in the absence of concomitant antidepressant agents.",0
Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.,1
"After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.",1
CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.,1
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
Accidental overdose of multiple chemotherapeutic agents.,0
"However, the use of atypical neuroleptics in modern psychopharmacotherapy is increasing, so the incidence of NMS under these drugs may also increase.",0
Further investigation excluded malignancy.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"After two weeks of drug treatment, the patient exhibited symptoms similar to those seen in the manic phase of bipolar affective disorder.",0
"Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.",1
"The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.",1
"CONCLUSION: The profound hypoxemia in this case was likely due to a combination of intra- and extrapulmonary shunt, both augmented by sodium nitroprusside.",0
The serumcholinesterase activity of the patient's serum increased by 55% (from 15% to 70%) following the injection.,0
Her serum total cholesterol was 515 mg/dl and triglyceride was 3378 mg/dl despite administration of 10 mg of simvastatin daily.,0
RESULTS: Central macular thickness decreased from 511 to 376 microm at month 4 in the treated eye and remained within 10% of this value during follow-up.,0
Easily reversible hypoxemia and hypotension induced by nimodipine.,1
Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.,1
The medication history is an integral part in the evaluation of a patient with hypoglycemia.,0
"Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).",1
"RESULTS: Exposure to the vanadium containing catalyst for 120 minutes resulted in a sustained decline in forced vital capacity and forced expiratory volume in one second, while the transfer factor for carbon monoxide did not change significantly.",0
Induction of glycosuria and hyperglycemia by topical corticosteroid therapy.,0
A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy.,1
"It is derived from 6-mercaptopurine, and these two drugs are often used interchangeably.",0
"The administration of ""sweet spirits of nitre"" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.",1
Dopamine D2 receptor occupancy 1.5 months after withdrawal still amounted to 83% and 50%.,0
"Three had low values of IgA, and all had normal values of IgM, IgD and IgE, and blood cells.",0
Complete dissolution was achieved with a combination of i.v. tissue plasminogen activator and heparin.,0
No objective data have been presented examining this issue.,0
"Effect of o,p'-DDD on serum and urinary androgens.",0
Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.,1
"While this report is anecdotal, any new drug warrants intense monitoring for unexpected toxicities in the post-marketing period.",0
Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.,1
CONCLUSION: Sexual side effects of fluoxetine may be more variable than previously thought.,0
We report the first case of Leuconostoc infection in a solid organ transplant recipient.,0
Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted.,1
All children showed a major clinical improvement within three months despite concomitant reduction of the prednisone dose.,0
"After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.",1
Data are presented to show that atopic cataracts and corticosteroids.,0
Immunoblastic lymphoma developed in a patient diagnosed as having angioimmunoblastic lymphadenopathy 5 years earlier.,0
"For one patient, the half-saturation constant was elevated 0.7 log units, suggesting reduction of retinal sensitivity, perhaps from decrease in retinal photopigment concentration.",0
He had been receiving dobutamine 3 mug/kg/min by intermittent i.v. infusion over four hours once weekly as an outpatient.,0
"After treatment with topical corticosteroids, antiglaucoma agents, cycloplegics, hypertonic saline and tears supplements, 27 (93%) eyes recovered completely within 3-14 days.",0
"Since this reaction was not present on the original aspiration cytology slides, the chemotherapy treatment must have induced this reaction.",0
We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.,1
The patient had a long history of constipation with daily use of mineral oil.,0
"In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.",1
Further investigation is needed to determine the scope of this troubling side effect.,0
Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.,1
"We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.",1
"The patient was left untreated and died 5 months after this diagnosis was made, of a second malignancy.",0
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
Visual changes secondary to initiation of amiodarone: a case report and review involving ocular management in cardiac polypharmacy.,1
Gemcitabine should be added to the list of drugs known to cause radiation recall.,1
This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.,1
Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.,1
Treatment with CSA was started after a nonresponding course of prednisone.,0
CASE SUMMARY: A 75-year-old white man received 23.6 grams of ofloxacin over a 51-day period for epididymitis.,0
Gastric variceal bleeding is a serious complication of liver cirrhosis.,0
"This side effect appears to be a universal property of effective antidepressants, including this new, purely serotonergic agent.",0
"However, like alcohol, their use can sometimes be a significant part of a dependence problem.",0
Two cases of long lasting bacteremia due to Mycobacterium avium complex despite new macrolides-containing regimens in patients with acquired immunodeficiency syndrome.,0
"The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.",1
A 25-year-old woman with mild hyperphenylalaninemia due to a PAH mutation of IVS12nt1g-->a/E390G has been treated for 1 year with BH4 therapy.,0
Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.,1
"The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.",1
Acute elevation of the ST segment in several ECG leads was observed in seven patients with bacterial shock during the course of therapy.,0
"She subsequently survived despite the development of convulsions, severe lactic acidosis (pH 6.86), hyperthermia (Temp 40.5 degrees C) and rhabdomyolysis.",0
Multiple sclerosis-like disease secondary to alpha interferon.,1
This is the first reported case of hepatolithiasis during octreotide therapy.,1
"In conclusion, we were confronted with an unusual case of pheochromocytoma associated with renal artery stenosis and the appearance of watery diarrhea some days after surgical treatment.",0
"We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.",1
Mucositis should be added to the list of conditions in which succinylcholine is contraindicated.,0
"On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.",1
An interaction between cytostatic and anticonvulsant drugs.,0
A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel.,1
Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.,1
"This case history, however, illustrates the susceptibility to these agents shown by some patients.",0
"The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.",1
She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.,1
"These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.",1
"Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.",1
Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.,1
The inferior alveolar nerve (IAN) contains mainly sensory fibers.,0
BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.,1
"To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan.",1
The purpose of this study is to investigate the efficacy of tissue plasminogen activator (tPA) in the treatment of total hyphema following ocular trauma or intraocular surgery.,0
"Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as ""red man syndrome"" and anaphylaxis.",1
"He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.",1
Successful desensitization to high-dose methotrexate after systemic anaphylaxis.,1
RESULTS: Nine children presented with clinically significant lead poisoning.,0
"After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.",1
Physicians treating patients with methotrexate for juvenile rheumatoid arthritis must be aware of this extraarticular side effect.,1
Transient postoperative pericardial constriction in a child.,0
Changed Michaelis-Menten parameters suggest that cisplatin increases the metabolic rate of phenytoin.,0
"She received 5-fluorouracil, doxorubicin, and cyclophosphamide.",0
Radiation recall with oxaliplatin: report of a case and a review of the literature.,0
Pamidronate therapy should be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.,1
"Before the infusion he was pretreated with ranitidine, cetirizine, hydroxyzine, montelukast, and prednisone.",0
No myeloma cells were found in the nervous system.,0
"We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.",1
CONCLUSIONS: A subgroup of patients with idiopathic sensorineural hearing loss (SNHL) will have steroid-dependent symptoms which can be confirmed using pure-tone audiometry.,0
After 10 d cholinesterase was still low and liver enzymes were elevated.,0
Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine.,1
Lower extremity arterial thrombosis following sonographically guided thrombin injection of a femoral pseudoaneurysm.,1
The occurrence of acute hepatitis is best known for ketoconazole.,1
Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.,1
The neuropathology of organ transplantation: comparison and contrast in 500 patients.,0
Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.,1
"Persistent ileus was treated with repeated doses of neostigmine, and gastrointestinal motility returned with prompt defecation.",0
Both were managed conservatively.,0
Complete remission was observed after 6 to 10 weeks of imiquimod 5% (10 mg/cm of skin cancer) treatment.,0
"Carbamazepine was discontinued upon admission, and the patient was treated with oral lactulose.",0
IMPLICATIONS:We discuss the successful management of gangrene of the upper and lower limbs after ergot-induced abortion by unlicensed medical charlatans in a developing country.,0
"METHOD: A 59-year-old, right-handed man of Caribbean-Hispanic descent underwent brain imaging studies, laboratory tests for AD, and serial neurologic and neuropsychologic evaluations.",0
This is the first series of cases to be reported demonstrating the potentially blinding complications of topical facial steroids.,0
"CASE REPORT: We hereby report a case of radiation recall dermatitis and myositis occurring on gemcitabine monotherapy, five months after completing chemoradiation for locally advanced pancreatic cancer.",1
T-cell receptor rearrangement analysis identified a monoclonal T-cell infiltrate.,0
"Except for 3 mild infections around the catheter exit site, there have been no complications of this therapy is 58 cumulative patient weeks.",0
A corneal and external disease specialist performed a complete ophthalmologic exam and obtained medical histories of the patients.,0
"The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).",1
"Continuous subcutaneously administered desferrioxamine may prove to be adaptable for long-term outpatient therapy, allowing patients with ongoing transfusion requirements to go into negative iron balance.",0
"The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.",1
"Her response to a postural challenge test, without medication, was normal.",0
"Sequential CT studies were performed in 24 patients with infantile spasms, before, during and after ACTH therapy, in order to analyze the relationship between the dose of ACTH and changes in CT scan findings.",0
All of them had the obstructive type of HCM (HOCM).,0
HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.,1
The drug was prescribed for transient ischemic cerebrovascular accidents.,0
"In the highly active antiretroviral therapy era, an increasingly large number of HIV-infected patients are developing non- AIDS-defining cancers (NADCs).",0
"However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.",1
CLL and AML/MDS were diagnosed concurrently in two patients.,0
One other patient on digoxin stopped taking it and developed cardiomyopathy.,1
We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.,1
Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast.,1
"The deposits were bilateral, yellow-white colored, stellate, and mainly peripheral.",0
We describe the first case of a Chinese liver transplant recipient with PVB19-induced PRCA during immunosuppressive therapy.,0
A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.,1
"We report a case of MMC-related hemolytic uremic syndrome, and discuss the etiologic parameters, clinical aspects, prognosis and treatment modalities of this severe syndrome.",1
Most patients with ergot toxicity present with symptoms of lower extremity claudication.,0
Fungal septicaemia in patients with cystic fibrosis associated with totally implantable venous access device system.,0
BACKGROUND: Drug toxicological screening is commonly used as a diagnostic tool in patients with suspected toxic ingestion.,0
It was possible to reproduce the disease by the intradermal injection of killed Group A streptococcal organisms.,0
"Two 65-year-old white men with coronary heart disease, given niacin therapy for dyslipidemia for 5 months, developed intense dental and gingival pain that was associated with increases in dose and that was relieved with discontinuance of niacin treatment.",1
"BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.",1
"Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.",1
"The patient was treated with ethanol, then fomepizole intravenously (15, 10, then 5 mg/kg), and hemodialysis.",0
"Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.",1
"There have been few reports, however, which have investigated a challenge with clozapine in patients previously showing eosinophilia.",0
CONCLUSION: Under certain circumstances topical brimonidine can cause paradoxical raised IOP necessitating vigilance in follow-up of patients on topical brimonidine.,1
A 55-year-old woman developed symptoms suggestive of hepatitis 12 weeks after first receiving methyldopa for hypertension.,1
Treatment of chromoblastomycosis due to Fonsecaea pedrosoi with low-dose terbinafine.,0
Its use is however not without adverse effect particularly bone marrow aplasia leading to varying degrees of cytopenias predominantly anaemia.,0
We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines.,1
"A new complication of cyclophosphamide, methotrexate, and 5-fluorouracil therapy.",0
Parents were thoroughly questioned but we could not find out a new traumatic head event.,0
Hydroxyurea associated with concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas in an elderly subject.,1
A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described.,1
This case provides an opportunity to discuss the difficulty of managing two potentially mortal conditions in which the treatment of pemphigus vulgaris may exacerbate the disseminated cryptococcal infection.,0
Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.,1
"We report here the successful use of ONSF to restore vision to three consecutive patients with pending anterior RION, and the importance of early identification and intervention in these potentially reversible cases.",0
Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.,1
The relationship between chronic inflammatory conditions and malignancy is complex.,0
Disopyramide (Norpace)-induced hypoglycemia.,1
We described the occurrence of L-dopa-induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.,1
"Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours.",1
Primary ovarian large B-cell lymphoma in patient with juvenile rheumatoid arthritis treated with low dose Methotrexate.,0
No renal or cardiac toxicity was observed.,0
"Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.",1
We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.,1
"Despite treatment with corticosteroids, she had rapid deterioration and died of respiratory failure.",0
"Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.",1
"Immediately after the intubation, she suffered cardiac arrest.",0
The global spreading of chloroquine-resistant falciparum malaria brings about an increasing use of quinine.,0
A patient with hematologic malignancy and hepatitis B virus (HBV) infection received chemotherapy containing a glucocorticoid.,0
CONCLUSIONS: Clinicians should be aware that Crohn's disease is a potential novel adverse drug effect of Copaxone.,1
Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.,1
A noninvasive method in the differential diagnosis of vecuronium-induced and magnesium-induced protracted neuromuscular block in a severely preeclamptic patient.,1
Focal renal cortical necrosis associated with zomepirac.,1
She was thus diagnosed as having AZ intoxication.,1
A report of two cases and review of the literature.,0
"Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.",1
"Medical evaluations included computerized tomography, lumbar puncture, complete blood counts, serum chemistries, and serologies.",0
"A repeat sodium was 124 mmol/L, and she was admitted.",0
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.,1
This child with acute lymphoblastic leukemia underwent a period of severe refractory lactic acidosis (pH between 6.81 and 7.00 and a serum lactate level up to 38 mmol/liter) leading to cardiac arrest.,0
"These findings are consistent with an immune-complex form of glomerulopathy in which gold is neither the antigen nor a hapten in the glomerular deposits, and they suggest the hypothesis that antibodies to tubular epithelial antigens induced by gold therapy may be a causative factor in the renal disease associated with gold therapy in rheumatoid arthritis.",1
Delivery was at term by caesarean section 2 days after spontaneous rupture of membranes and failure to progress in labour.,0
Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.,1
"Akathisia appeared to be a common side effect of fluoxetine and generally responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both.",1
"Consistent with the data in healthy volunteers, a major interaction between esomeprazole and atazanavir-ritonavir was observed in this patient-marked reductions in atazanavir trough plasma concentration and in the area under the concentration-time curve from 0-24 hours-whereas an interaction between esomeprazole and fosamprenavir-ritonavir was not apparent in this patient.",0
This is the second report of lactic acidosis in a patient on stavudine and lamivudine.,1
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
Nummular headache: a series with symptomatic and primary cases.,0
"Concern usually arises when a medication is added to a continuing regimen, though discontinuation of a medication can also have an impact.",0
After drainage of the effusion she received combination chemotherapy with CDDP and VDS.,0
We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).,1
Serum myoglobin was over 3000 ng/mL.,0
It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.,1
The partial lesion of the cord at T7 predominantly involved the spinothalamic pathways on the left side.,0
"In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.",1
Two patients on long-term lithium therapy developed the nephrotic syndrome.,1
"The electrocardiogram (ECG), which was read as normal prior to ritodrine infusion, demonstrated a type I second-degree AV block which disappeared upon discontinuation of ritodrine therapy.",1
The development of a rifampin-impregnated silicone catheter yielded excellent results in infection prevention and treatment in vitro as well as in an animal model.,0
"We encountered two cases of macular infarction that occurred after vitrectomy performed for mild endophthalmitis, which, on culture, yielded Staphylococcus epidermidis.",0
"In 1993, a case of PI with nephrotic syndrome following steroid treatment was reported in Japan.",0
Papillary necrosis associated with the HIV protease inhibitor indinavir.,1
BACKGROUND: The incidence of Mycobacterium avium complex (MAC) infection is increasing among patients with AIDS.,0
A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.,1
Homozygous loss of TSC1 was identified in one PEComa.,0
"He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy.",1
Recommended treatment duration is 6 to 12 months with frequent imaging.,0
How safe is our blood transfusion?,0
"Prior to surgery, levodopa induced dyskinesia had improved (< or = 50%) under treatment with amantadine (400 mg/day, po) in all three patients.",1
"However, cough mixtures are a readily available source of opioids.",0
"DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.",1
"Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.",1
"We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.",1
"Antitumour necrosis factor alpha (TNFalpha) antibodies have recently been used in order to treat Crohn's disease, but their effect on cholestasis in humans has not been previously described.",0
"In five of these cases the episode began after an unusually large dose, in three after a therapeutic one with a latency of about 24 hours.",0
"Due to its low volume of distribution (0.6 L/kg), low protein binding (about 15%) and water solubility, acyclovir is an example of the ideal drug that can be removed by hemodialysis.",0
"After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.",1
DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.,1
Brain metastasis was detected in one patient at 7 months after initial therapy and was treated with stereotactic radiotherapy combined with whole brain irradiation.,0
Most electrophysiological responses were usually just within normal limits; two patients had subnormal Arden electro-oculography indices; and one patient showed an abnormally delayed photopic b wave.,0
"The rash was confluent over the radiation ports, both anteriorly and posteriorly.",0
"Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.",1
Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.,1
"The leucopenia and thrombocytopenia resolved on the 7th and 13th days of hospitalization, respectively.",0
"There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.",1
The overall rate of avascular necrosis in Crohn's disease was less than 0.5% but for men with Crohn's disease was about 1%.,0
"CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.",1
A 74-year old white man was undergoing treatment with palliative chemotherapy for Stage IV Prostate Adenocarcinoma with multiple osteoblastic metastases.,0
Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.,1
"The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.",1
"Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued.",1
"In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.",1
"We report a case of amiodarone-induced thyrotoxicosis of protracted duration, unresponsive to conventional thionamide therapy, with therapy limited by severe adverse drug reactions.",1
We report a case of a child with neurodevelopmental delay with chronic constipation and a history of chronic mineral oil ingestion presenting as asymptomatic exogenous lipoid pneumonia (ELP).,1
CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.,1
His medical history was significant for 5-FU bolus injections for intestinal cancer since May 1998.,0
In four of five eyes the LASIK flap was amputated.,0
An 8-year-old boy was found to be hypertensive on routine exam (144/88).,0
"A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.",1
No concrete predisposing factor was found to be associated with the occurrence of the lesions on the face.,0
Urine toxicology screening was negative.,0
"One year later, she has minimal joint discomfort and no rash or gastrointestinal symptoms despite also discontinuing prednisone and methotrexate.",0
"We believe the temporal association of the abnormal liver enzymes in this patient, in the absence of other offending agents, argues strongly in favor of 6-TG as a cause of liver enzyme abnormalities.",1
The occurrence of severe AIHA in CLL patients treated with fludarabine has been reported by several authors.,1
"RESULTS: Of the 18 patients treated with MMF, there were 11 men (61.1%) and seven women (38.8%), with an overall mean age of 55.5 years.",0
We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.,1
Bleomycin pneumonitis potentiated by oxygen administration.,1
These cases were chosen for study because they were all deaths as a result of suicidal ingestion of drugs in which quetiapine was considered a significant factor.,1
"We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.",1
"Over the following months, he developed unusual symptoms involving the legs and genitourinary tract which, only after extensive investigations, were attributed to ischemic damage to the spinal cord related to the surgery.",0
Angioedema and maculopapular eruptions associated with carbamazepine administration.,1
Stage II lactogenesis was delayed until the tenth postpartum day at which point the patient's breasts became fully engorged.,0
Such a case induced by hypothyroidism complicating long-term therapy with amiodarone in a 45 year old woman with pre-excitation is presented.,1
Ciliary beat frequency (CBF) was measured using video microscopy.,0
"This extremely rare combination of haematomas may have been caused either by rupture of a small vessel in the arachnoid membrane or by rupture of the arachnoid membrane itself, secondary to a massive haemorrhage in the subarachnoid space.",0
PURPOSE: To report spectral domain optical coherence tomography (OCT) and angiographic findings in exudative retinal detachment complicating central serous chorioretinopathy.,0
The hypercalcemia responded to discontinuation of rhGH and a single dose of intravenous pamidronate disodium and has not recurred in 8 months of follow-up.,1
A literature review revealed 83 other reported cases of rifampicin-induced renal insufficiency.,1
Retinoic acid may increase the risk of bone marrow transplant nephropathy.,1
"He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.",1
"A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.",1
A 33-year-old male presented with brown discolouration of the fingernails following the application of 4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months.,1
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
Two months later repeat colonoscopy with biopsies showed no evidence of collagenous colitis.,0
Scant data are available regarding the effect of hemodialysis on the elimination of argatroban.,0
Clozapine induced polyserositis.,1
Whether these drugs adversely affect hepatobiliary scans is unknown.,0
"However, prolongation of 5-FU half-life and an increase in INR have been reported with the concurrent use of 5-FU and warfarin.",1
"On hospital day 2 his platelet count dropped to 47,000/microl and bottomed out at 36,000/microl by day 3 with other blood cell counts remaining within normal limits.",0
Rigorous diagnostic procedures with repeated scintiscans and TSHRAb titering are necessary to avoid a false diagnosis and inappropriate therapy.,0
After clinical assessment undiagnosed chest pain can become a difficult problem.,0
"That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).",1
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).,1
INTRODUCTION: Tuberculosis is a rare but serious complication after transplantation.,0
Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx.,0
"There was no sign of bacterial, viral, or fungal infection in either case.",0
A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.,1
A case of Sweet's syndrome following septic pulmonary emboli after high-dose chemotherapy for advanced testicular cancer.,0
"Shewanella spp. are an uncommon cause of human infection, with exposure to water being the commonest source.",0
"A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",1
"BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.",1
"We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).",1
"The baby girl was fed with pasteurized maternal milk, and she had a normal growth.",0
Cutaneous seeding is a rare complication of interventional ultrasound procedures.,0
Propranolol: an unrecognized cause of central nervous system dysfunction in patients undergoing cardiopulmonary bypass.,1
"The subsequent conditioning regimen included busulfan 16 mg/kg, Ara-C 12 g/m2 and melphalan 140 mg/m2.",0
Adenosine-induced ventricular fibrillation.,1
"In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.",1
"In conclusion, the locally prepared LC was able to control the bleeding episodes in a haemophilia A patient with high inhibitor.",0
One patient developed large intramural esophageal hematoma as a complication of heparin therapy.,1
The patient suffered excessive toxicity with low-dose irinotecan although no functional polymorphism in UGT1A1 was identified.,0
A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.,1
MK-0457 (VX-680) is a small-molecule aurora kinase (AK) inhibitor with preclinical antileukemia activity.,0
"Inflammatory myopathy has been associated with systemic inflammatory processes, endocrinopathies, malignancies and infections.",0
Chemotherapy is frequently used to treat adenocarcinoma.,0
Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.,1
Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.,1
The observations made in these three patients may give support to the hypothesis that cholinergic activity has pathogenic significance in depressive syndromes.,0
Intrapericardial infusion of 5-fluorouracil.,0
"According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible.",1
METHODS: A 55-year-old man had diabetes with unilateral rubeosis and macular edema.,0
Patient survival depends on prompt referral to a specialist burns unit.,0
"Autopsy demonstrated extensive necrosis of the tumor mass, as well as necrotizing vascular damage within the neoplasm.",0
CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.,1
"Because she could not tolerate ketoconazole and was hypersensitive to griseofulvin, she received itraconazole with complete recovery within 30 days.",0
We suggest that objective evaluation of retinal function with electrophysiological methods should be performed in patients with visual disturbance during treatment with rifabutin.,1
"One was infected by PVB19-contaminated blood transfusion, whereas the other had become infected naturally.",0
"During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.",1
We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.,1
"On examination, rigors, shallow inspirations, and chills were noted.",0
He presented the following day with uncorrected visual acuity (UCVA) in the affected eye of 3/200 and organic foreign body deposits underneath the flap.,0
We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI).,1
Hepatotoxic effects in a child receiving valproate and carnitine.,1
Pulsed-field gel electrophoresis (PFGE) was used to determine whether the isolated microorganisms were the same.,0
"In the presence of risk factors, such as cGVHD, prophylactic treatment for toxoplasmosis should be reinstituted; Trimethoprim-sulfamethoxasole most probably prevented earlier reactivation of toxoplasmosis in our patient.",0
The photosensitivity is still present 3 years after the withdrawal of quinine.,1
Abnormal retinal function associated with isotretinoin therapy for acne.,1
"Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.",1
"In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.",1
Acute bilateral phrenic neuropathy following treatment with adalimumab.,1
Successful treatment of aortic thrombosis after umbilical catheterization with tissue plasminogen activator.,0
Darifenacin is a muscarinic antagonist which was FDA approved for the treatment of overactive bladder in December 2004.,0
Methotrexate-induced papular eruption following treatment of psoriasis has not been previously reported.,1
"Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.",1
"It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.",1
"We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.",1
"Commonly reported adverse effects of the drug include nausea and vomiting, constipation, headache, and fatigue, as well as myelosuppression, which may be dose limiting.",0
Carboplatin and etoposide combined with radiotherapy for limited-stage small-cell esophageal carcinoma: three cases and review of the literature.,0
Isolation of Mycobacterium thermoresistibile following augmentation mammaplasty.,0
We recommended periodic examination of the serum proteins in patients receiving diphenylhydantoin in order to detect development of monoclonal gammopathy.,1
Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.,1
"Meglumine antimoniate, amiodarone and torsades de pointes: a case report.",0
The patient remained constantly HIV negative during 14 months of follow-up.,0
"We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.",1
Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.,1
This report describes the analytical techniques and significance of the zolpidem findings.,0
Flaccid quadriparesis was noted after discontinuation of vecuronium.,1
"Fever, pulmonary infiltrates, and pleural effusion following acyclovir therapy for herpes zoster ophthalmicus.",1
We conclude that autoimmune hemolytic anemia may be an unusual presentation for postirradiation sarcoma.,0
"Three patients with a cellular immunodeficiency were treated with rifabutin, clarithromycin and ethambutol for a disseminated infection with Mycobacterium avium-intracellulare complex (MAC).",0
"Does the use of insulin in a patient with liver dysfunction increase water retention in the body, i.e. cause insulin oedema?",1
"Although a neurological evaluation by a neurosurgeon could suggest the presence of a vague cerebellar sign, neuro-otological evaluation disclosed diverse abnormal findings which clearly demonstrated the presence of dysfunction in the cerebellar system, especially of the verminal and flocculonodular lobe lesion.",0
A 32-year-old primigravida was admitted because of premature labor at 31 weeks of gestation.,0
"The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.",1
We report on a patient who developed the clinical findings of pulmonary eosinophilia.,0
Prick tests were negative in both the antineoplastic agents.,0
Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.,1
This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.,1
We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.,1
RESULTS: All three patients responded to risperidone and experienced no extrapyramidal side effects.,0
"When a 34-year-old woman had dyspnea and chylothorax 8 months postpartum, lymphangiomyomatosis was diagnosed by open-lung biopsy.",0
PURPOSE: To report new indocyanine green angiographic (ICGA) findings after intravitreal bevacizumab (IVB) for myopic choroidal neovascularization (mCNV).,0
"We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.",1
Amifostine-induced fever: case report and review of the literature.,1
Sodium thiosulfate in the treatment of tumoral calcifications in a hemodialysis patient without hyperparathyroidism.,0
There was no reaction to the antibiotics.,0
"Naratriptan was extremely well tolerated, with no cardiovascular adverse events reported or observed.",0
"Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misdiagnosed in children.",1
She received 3.8 mg cumulative dose of vincristin before development of ptosis.,0
Therapy-related leukemia and myelodysplastic syndrome in chronic lymphocytic leukemia.,0
Retinal dysfunction and anterior segment deposits in a patient treated with rifabutin.,1
The use of felbamate in patients with periodic lateralized epileptiform discharges (PLEDs).,0
"After immediate treatment with low molecular weight heparin (enoxaparin), the thrombus improved without any additional complications.",0
We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.,1
We report herein the case of a 69-year-old Japanese man with acquired von Willebrand syndrome associated with monoclonal gammopathy of undetermined significance who developed IgG1-kappa antibodies against von Willebrand factor (VWF).,0
We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.,1
Acetazolamide-accelerated anticonvulsant osteomalacia.,1
"The organism was unusual in its resistance to chloramphenicol and ampicillin; however, it was sensitive to a sulfonamide and trimethoprim.",0
Crumley).,0
Eosinophilic pleural effusion is defined as an effusion in which eosinophils constitute more than 10% of white blood cells.,0
Particular attention should be paid to tiny skull lesions and to key events preceding the pain.,0
"We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.",1
Drug induced myopathies have been implicated with the use of several medications.,0
"Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).",1
"Accordingly, careful monitoring of liver function parameters should be performed both during and after treatment when onychomycosis requires prolonged itraconazole administration, even in asymptomatic patients lacking apparent risk factors of hepatic injury.",0
Baclofen withdrawal: a cause of prolonged fever in the intensive care unit.,1
"These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.",1
OBJECTIVES: To describe the dissolution of a large organized intraatrial catheter-tip thrombus using a novel aggressive dose escalation of tissue plasminogen activator infusion.,0
CASE SUMMARY: A 58-year-old white woman developed fulminant liver failure while being treated with the macrolide antibiotic clarithromycin for pneumonia.,1
"We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.",1
"She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared.",1
The drug was discontinued and papular lesions gradually disappeared.,0
"While an elevated incidence of lung cancer has been observed in patients with RA or psoriasis, there has been no report of psoriatic arthritis associated with lung cancer.",0
"Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.",1
"As emergency surgical intervention of thrombotic prosthetic cardiac valves is correlated with high mortality, fibrinolytic therapy has been recently recommended as a therapy with high efficacy and no severe side effects.",0
Localized dyskeratotic plaque with milia associated with sorafenib.,1
A more serious development of adrenal insufficiency may occur upon the improper replacement of systemic steroids.,0
OBJECTIVE: To report a case of phenolphthalein-induced toxic epidermal necrolysis (TEN) in a patient maintained on several other medications more commonly known to be associated with TEN.,1
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
"On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).",1
Cerebral vasospasm on MR angiography (MRA) has been noted in cases due to eclampsia.,0
The disease predisposes to severe vincristine neurotoxicity.,1
Fludarabine phosphate is currently proposed for the treatment of refractory chronic lymphocytic leukemia (CLL).,0
Regression of thyrotoxic ophthalmopathy following lithium withdrawal.,1
"The hepatitis C infection was eradicated, but he continued to be diabetic requiring insulin therapy during the follow-up.",0
Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.,1
Chemotherapy was stopped and systemic application of prednisolone was initiated.,0
"CD4 count was 326 +/- 124 cells/mL (range, 198-467) and all patients presented HIV viral load < 75 copes/mL.",0
High-grade atrioventricular block during dipyridamole stress testing.,1
"INTRODUCTION: Despite high success rates with free-tissue transfer, flap loss continues to be a devastating event.",0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.,1
Two of the patients who had acute renal failure while receiving ACE-inhibitor therapy experienced a recurrence when rechallenged with such therapy.,0
We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.,1
Repeat catheter and peripheral culturing occurred 72 hours after the 5-day period.,0
"In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.",1
Relationship of eye burns with calcifications of the cornea?,0
A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.,1
"Two of them could not be considered primary: in one the pain was related to an underlying, pointed and benign lesion disclosed only by magnetic resonance imaging (case 1); the second one had persistent NH days after trans-sphenoidal surgery for a pituitary adenoma, similar to a postcraniotomy headache (case 2).",0
"One of the occult blood cards showed a positive result, and colonoscopy revealed a 5-cm lesion, identified as Dukes' A adenocarcinoma.",0
Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.,1
Erosive oral lichen planus (OLP) is a painful chronic inflammatory disease that is sometimes resistant to systemic or topical therapies.,0
"We report a case of cytomegalovirus retinitis which occurred 6 months after renal transplantation and was successfully treated with an investigational drug, ganciclovir (DHPG [Dihydroxy propoxymethyl guanine], Cytovene, BW-B759U), via intravenous administration, with resolution of active retinal lesions and the cessation of cytomegalovirus shedding in the urine.",0
Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.,1
"CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.",1
Self-limited edema is a well-recognized complication of insulin therapy.,1
The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.,1
Coexistent psoriasis and lupus erythematosus treated with alefacept.,0
Bronchoscopy revealed diffuse erythema without bleeding.,0
After a seizure-free period of 3 months the patient died from hepatic failure resembling Reye syndrome.,0
Both of these findings are due to the unique effects of rifampicin on steroid metabolism.,0
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).,1
"The child developed a severe and florid form of mucocutaneous oral ulceration, severe ocular manifestations, along with marked constitutional disturbances and dehydration.",0
Prophylactic administration of thiabendazole is probably preventive.,0
"The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.",1
"The patient had flowing ossification along thoracic spine resembling diffuse idiopathic skeletal hyperostosis (DISH), but there was no ligament calcification in the lumbar spine or pelvis.",0
The pulses consisted of four repeated doses of 500 mg of hydrocortisone given intravenously over 20 to 30 minutes at six-hour intervals or of single intravenous injections of 30 mg/kg of methylprednisolone.,0
"Three PC lines broke at the time of removal resulting in a length of line remaining in the central venous system (the superior vena cava, innominate vein, and bracheo-cephalic subclavian junction).",0
"Although they had only a few nodules at diagnosis, the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients.",1
This can be prevented by prompt recognition and specific treatment.,0
PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.,1
This paper reports a case of fatal perhexiline maleate liver injury.,1
"After the institution of the combined therapy with corticosteroid, anticoagulant, and dipyridamole, urinary protein excretion was attenuated to less than 1.0 g/day.",0
Blood transfusion and natural infection cases.,0
Two patients with non-miliary pulmonary tuberculosis developed a syndrome resembling adult respiratory distress following initiation of drug treatment.,0
"The incidence of cerebellar toxicity approaches 30 percent, with irreversible ataxia reported in up to 16.7 percent.",0
"We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.",1
"Both patients recovered immediately without any signs of adverse effects and the two shunt systems have now been working properly for more than 36 and 21 months, respectively.",0
She had no other causes of immunosuppression.,0
"Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.",1
Steroid induced avascular necrosis of bones in eighteen sites: a case report.,0
CONCLUSIONS: We report this case of the concomitant appearance of multiple skin cancers and nail changes associated with hydroxyurea use.,1
"In humans, 80-90% of an administered dose of 5-fluorouracil (5-FU) is degraded by dihydropyrimidine dehydrogenase (DPD; EC 1.3.1.2), the initial rate-limiting enzyme in pyrimidine catabolism.",0
Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).,1
This case report describes the diagnostic workup in a child with anaplastic ependymoma and inconclusive MRI (magnetic resonance imaging) and PET (positron emission tomography) findings.,0
"She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.",1
We describe the case of a 50-year-old woman with advanced non-small cell lung cancer who developed status epilepticus shortly after receiving cisplatin and gemcitabine chemotherapy.,1
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.,1
"Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.",1
Successful rescue of severe recurrent hepatitis C with interferon and ribavirin in a liver transplant patient.,0
"Confidence and conditional confidence levels for the preferred decision are derived from gaussian theory, and the mutual information index that identifies probabilistically important tree variables is provided.",0
High-dose phosphate treatment leads to hypokalemia in hypophosphatemic osteomalacia.,1
CONCLUSION: Gemcitabine-induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy.,1
BACKGROUND: Metastatic renal cell carcinoma (MRCC) has been characteristically unresponsive to chemotherapy.,0
It occasionally accompanies the heparin-associated thrombocytopenia and thrombosis syndrome.,1
"In this case of CPM, blindness was encountered and was thought to be ""hysterical."" The blindness went away after four months.",0
"However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.",1
We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.,1
"We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.",1
"We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.",1
She had been treated without complications with six courses of docetaxel and trastuzumab in combination with dexamethasone with partial remission of disease.,0
A 54-year-old man received combination chemotherapy with nedaplatin and irinotecan as salvage chemotherapy for refractory non-seminomatous testicular cancer.,0
"Computed tomography angiography of her chest revealed multiple bilateral pulmonary emboli with a moderate clot burden, which resulted in her hospitalization.",0
Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.,1
"CASE SUMMARY: A 59-year-old man was diagnosed with squamous-cell carcinoma of the lung in T4N2M0 stage and treated with cisplatin, vinorelbine, and gemcitabine.",0
Membranous nephropathy in rheumatoid arthritis.,0
"From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).",1
"CONCLUSION: The use of HDR radiation in these patients eliminated radiation exposure to care-givers and permitted constant nursing care and interaction among the parents, nursing personnel, and child.",0
Pulses have been given for periods up to three years without evident toxicity.,0
No oligodendroglias with intranuclear inclusions were found.,0
Akathisia should be considered in all cases of apparent nonresponse to atypical antipsychotics.,0
"When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.",1
Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.,1
Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.,1
"With many HIV-infected patients surviving alkylator and topoisomerase inhibitor-based treatment and radiation therapy for AIDS-defining cancers and NADCs, long-term follow-up for therapy-related complications assumes greater importance.",0
"With the use of the newer antidepressants beyond the traditional tricyclics and monoamine oxidase inhibitors, newer options in headache prophylaxis are provided as well as the potential for undesirable and even potentially life-threatening interactions between medications.",0
"METHODS: We present a case report on the use of an indium (111) diethylenetriaminepentaacetic acid (DTPA) flow study in the evaluation of a lumbar swelling in a 16-year-old girl with spastic cerebral palsy, treated with continuous intrathecal baclofen (CITB).",0
"She was treated with methylprednisolone (40 mg i.v. q6h), aminophylline (loading with 5 mg/kg and maintained with 0.6 mg/kg/hr i.v. drip), nebulized terbutaline sulphate (5 mg q6h), oral procaterol 12.5 micrograms bid, along with oxygen therapy.",0
Gabapentin toxicity in renal failure: the importance of dose adjustment.,1
"While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect.",1
"Before invasive procedures are performed, thought must be given to what changes in treatment may be made when results are known.",0
Nail staining from hydroquinone cream.,1
"Intravenous haloperidol is generally well tolerated, but multiform ventricular tachycardia has been reported.",1
"Patients treated with captopril who develop ""atypical cholangitis"" should be suspected of having captopril-associated liver damage.",1
Our objective is to present a retrospective analysis of the DWI findings in four patients who suffered subacute neurotoxicity after intrathecal MTX.,1
Botulinum toxin for palliative treatment of epiphora in a patient with canalicular obstruction.,0
"Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.",1
A review of the literature showed no previous description of this pattern in benzodiazepine coma.,1
He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed.,0
"Because lupus patients are susceptible to infections associated with disease exacerbation or immunosuppressive treatment, recurrent infections might be expected during the disease course without need for further evaluation of the immunodeficiency.",0
Spontaneous nasal septal perforation with antiangiogenic bevacizumab therapy.,1
"To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mitomycin C has not been reported.",1
The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent.,1
"On the 4th day, the pattern of VWFMs was completely normalized and appeared to persist until the 10th day.",0
"Interferon-based treatments have the potential to decrease the burden of disease, but are complicated by side effects, including neuropsychiatric symptoms.",1
"Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during amphotercin B administration.",1
Pityriasis lichenoides-like eruption occurring during therapy for myelogenous leukemia.,0
Fever and chills occurred on seven occasions.,0
"This behavior consisted of an apparent infatuation with a ward nurse, which ceased after medication was discontinued.",0
Virilizing adrenal tumor in a child suppressed with dexamethasone for three years.,0
Bradycardia and congestive heart failure associated with ocular timolol maleate.,1
"In this report, we suppose the possibility to develop a foetal malformations after a long-term wash out from isotretinoin therapy.",0
He had complex partial seizures refractory to several antiepileptic drugs since 4 years of age.,0
Three of 38 children given high-dose cytosine arabinoside therapy developed a previously undescribed complication.,0
Statin-associated myasthenia gravis: report of 4 cases and review of the literature.,1
High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.,1
Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.,1
"We calculated the changes in alpha(1)-adrenoceptor occupancy by endogenous norepinephrine during treatment with the usual doses of milnacipran, fluvoxamine and imipramine by using pharmacokinetic and pharmacodynamic parameters obtained from the literature.",0
"After discontinuing captopril and starting systemic steroids, her symptomatology rapidly improved, and her eosinophilia and radiographic abnormalities both resolved.",1
More attention should be focused on long term effects of neuroleptics.,0
A simple dropper that would withdraw only one drop and deliver the same would resolve this problem.,0
Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.,1
A 35-year-old woman was treated with intraventricular methotrexate (MTX) with a total dose of 70 mg followed by cytosine arabinoside (Ara-C) with a total dose of 80 mg for meningeal metastasis of breast carcinoma.,0
The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.,1
"To date, only three cases of seizures associated with amphotericin B have been reported in the literature, but healthcare providers should be aware of the potential for this rare adverse effect.",1
Gallstones and bile sludge are common side effects of octreotide therapy but rarely become symptomatic or require treatment.,1
"In patients with recurrent malignant glioma, treatment-related myelodysplastic syndrome (t-MDS) and acute leukemia are rare adverse effects because the median survival after relapse is limited.",0
"One previous study of four transplant patients whose immediate post-transplantation immunosuppression utilized corticosteroids, cyclosporine, MMF, and anti-T-lymphocyte globulin noted anemia in 13% of them.",0
"During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.",1
"Pleuropulmonary changes during treatment of Parkinson's disease with a long-acting ergot derivative, cabergoline.",1
"He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.",1
Hypoglycaemic coma recurred.,0
This adverse reaction is more common in children than adults and is rarely symptomatic.,0
"Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.",1
Progression of the clinical picture was documented over 15 years of follow-up.,0
We describe a patient who had a systemic allergic contact dermatitis to 8-MOP develop during her second course of PUVA treatment for psoriasis.,1
A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.,1
BACKGROUND: Second-line treatment options are limited in controlling advanced thoracic cancer in patients who have progressed following first-line chemotherapy.,0
Long lasting respiratory depression induced by morphine-6-glucuronide?,1
The patients treated with bromocriptine at 7.5-15 mg/day adjunctive to l-dopa were selected to replace bromocriptine with pergolide of the equivalent dosage approved in Japan.,0
"From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).",1
One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.,1
"However, other factors or drugs (e.g. cresol) are thought to induce MH.",1
A typical case of dextran-40 associated acute renal failure is presented.,1
Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.,1
Anesthesiologists and surgeons should be aware of this uncommon complication than can occur with the use of peritonsillar bupivacaine infiltration for pain control in tonsil surgery.,0
"All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.",1
MDS was diagnosed 8.4 months after beginning TMZ.,0
"We describe a case of 73-year-old patient who has been operated in emergency on triple coronary artery bypass graft (CABG), which was complicated with respiratory insufficiency and devastating mediastinitis.",0
We describe a 28-year-old man who was brought to the emergency department with a new-onset seizure and clinical signs and symptoms consistent with advanced delirium tremens.,0
"However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.",1
Early blindness and coma during intrathecal chemotherapy for meningeal carcinomatosis.,0
"The target antigen, cause of the positive direct antiglobulin test (DAT) and mechanism of hemolysis have been the subject of controversy.",0
An increase in tumor volume of 25% was observable 15 days after the beginning of therapy.,0
The additional finding of extensive resorption of the outer cortical surface and bone formation at the inner surface suggested a reversible phase after discontinuation of treatment.,0
The reactive process included an infiltrative superficial dermatitis and a mural folliculitis with prevalent participation of macrophages and lymphocytes.,0
"Over several weeks, all neurologic and imaging deficits resolved.",0
Striking regression of radiation-induced fibrosis by a combination of pentoxifylline and tocopherol.,0
Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.,1
Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.,1
The potential for absorption is not well described in patients with impaired gastrointestinal (GI) mucosa.,0
"The known side effects of sibutramine, ie, hypertension and tachycardia, depend on its adrenergic and serotoninergic effects.",1
Metoclopramide-induced parkinsonism.,1
"The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible.",1
Oral 25-hydroxyvitain D3 in treatment of osteomalacia associated with ileal resection and cholestyramine therapy.,1
"An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.",1
The male patient was treated with 225-mg/day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks.,1
A 43-year-old woman with multiple sclerosis (MS) had nephrotic syndrome 21 months after starting treatment with interferon (IFN)-beta-1b (subcutaneous administration).,1
Biophysiological effects of Ukrain therapy in a patient with breast cancer (case report).,0
Antibiotic treatment should be continued.,0
Quetiapine-induced leucopenia and thrombocytopenia.,1
A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.,1
The prognosis of t-MDS is generally poor.,0
"Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.",1
"Long-term treatment in gut neuroendocrine tumours, efficacy of oral administration, and possible use in non-tumoural inappropriate TSH hypersecretion.",0
Controversy as to what constitutes a safe and effective dose of these medications still exists.,0
"From the literature, 72 references were reviewed.",0
The INR remained subtherapeutic for 5 weeks despite weekly warfarin dose increases.,0
"In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.",1
"One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy.",1
We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.,1
The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature.,0
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).,1
"Immunosuppression related to HIV infection, immunosuppressive treatment, organ transplantation, and neoplastic diseases increases the risk for Leishmania-infected people to develop visceral illness.",0
"CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.",1
Near fatal acute colchicine intoxication in a child.,1
A 56-year-old Caucasian man who received concomitant chemotherapy and radiation for head and neck cancer developed fever concurrent with the administration of amifostine.,1
Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.,1
"In conclusion, even if in our case no surgical treatment was used and although spontaneous resorption has been described for some materials, early surgical exploration with removal of the material and decompression of the IAN is suggested, irrespective of the material used, because the severity of nerve damage can increase with the duration of the injury.",0
After treatment with prednisolone a complete resolution of the dyspnea was observed.,0
First trimester disulfiram exposure: report of two cases.,0
Disseminated salmonellosis in a patient treated with temozolomide.,1
"The pathophysiological mechanisms remain unknown, although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab.",1
"After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).",1
PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.,1
"CONCLUSION: Identification of bacteria in blood components should trigger a comprehensive donor evaluation, particularly if donor bacteremia is suspected.",0
"One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.",1
He recovered without complications with imipenem-cilastatin prophylaxis.,0
"The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.",1
Clofazimine enteropathy in a pediatric bone marrow transplant recipient.,1
Plasma concentrations were also measured before and after ten dialysis sessions during four courses of ifosfamide therapy.,0
Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.,1
A 15-year-old boy developed nephrotic syndrome and acute renal failure 4 years after allogenic bone marrow transplantation (BMT) for lymphoid crisis of chronic myelocytic leukemia.,0
"The cases are important in documenting that drug-induced dystonias do occur in patients with dementia, that risperidone appears to have contributed to dystonia among elderly patients, and that the categorization of dystonic reactions needs further clarification.",1
The failure of high doses steroids to alter the course of illness and to completely suppress the thyroidal inflammatory process is highlighted.,0
Prolongation of the QT interval and ventricular tachyarrhymias have been described in patients on amiodarone therapy.,1
"After left salpingo-oophorectomy had been performed, the patient chose to terminate the pregnancy before the initiation of combination chemotherapy with bleomycin, etoposide, and cisplatin.",0
These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).,1
"Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.",1
"OBJECTIVE: We report a patient who developed neutropenia on clozapine, but behind the cell count decrease showed to be a diurnal variation of the white blood cells (WBC).",1
"He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.",1
Morphological findings on sural nerve biopsies revealed both axonal degeneration and segmental remyelination.,0
"Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.",1
"The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.",1
"Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.",1
The drug should be withdrawn immediately if there is a suspicion of blood disorders.,0
The patient presented with loss of consciousness and died after 5 days of antifungal therapy with liposomal amphotericin B.,0
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
"The presence of diabetes constitutes a cluster of particularly high cardiovascular risks in patients, both regarding diabetic damage and hypertensive damage.",0
"Before the treatment of co-trixomazole, their serum levels of creatinine showed upper limits of normal ranges.",0
"To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.",1
"Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.",1
A cause-effect relationship to capecitabine was suggested due to resolution of headache with capecitabine withdrawal and reappearance with capecitabine rechallenge.,1
"In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.",1
Clonidine-induced bradycardia in patients with spinal cord injury.,1
"A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.",1
AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.,1
These cases indicate that sulpiride can cause tardive dyskinesia and that this drug should be administered with caution.,1
CONCLUSIONS: The piloerection observed after the replacement of fluvoxamine with milnacipran in this patient appears to have been due to an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine induced by milnacipran.,1
"Pipotiazine palmitate, a long acting drug, indeed: a case report.",0
Cicatricial entropion associated with chronic dipivefrin application.,1
"Although numbness of the left arm was not improved, her overall pain score was reduced by 2 on the 7th day after the start of SKT.",0
We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment.,1
The patient was a nonsmoker with no respiratory illnesses.,0
Salicylate hepato toxicity in rheumatic fever.,1
A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.,1
We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines.,1
"Sometimes the presentation is with diabetic ketoacidosis, requiring insulin treatment, which can nevertheless be reversible.",0
"Medication comprises of bronchodilators, corticosteroids and anticholinergic drugs.",0
This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.,1
We describe the clinical and histologic features of this chemical and traumatic alopecia as well as that of frontotemporal chronic traction alopecia resulting from use of sponge rollers.,0
"We report six cases of endometrial sarcomas complicating ovarian thecomas, polycystic ovarian disease, or prolonged estrogen therapy.",0
We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.,1
"Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.",1
"Her initial clinical presentation suggested postoperative infection, but the inflammation continued to progress despite antimicrobial therapy.",0
"Administration of lamotrigine, especially in combination with valproic acid, may lead to the development of TEN.",1
Tics and Tourette syndrome are common comorbidities of patients diagnosed with attention-deficit/hyperactivity disorder (ADHD).,0
Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia.,1
"The peritoneal dialysis catheter was removed in 53% of cases, although this was rarely considered necessary for cure of tuberculosis.",0
"As is known, tamoxifen therapy is related to endometrial proliferation, hyperplasia, polyp formation, invasive carcinoma and uterine sarcoma.",0
Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.,1
We report a case of sustained hypotension after administration of parenteral verapamil.,1
Enoxaparin-induced generalized exanthem.,1
METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.,1
"Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.",1
This article reviews case reports and clinical studies of thrombolysis during and shortly after CPR in order to estimate the risk of severe bleeding events caused by CPR in association with thrombolysis compared with CPR without thrombolysis.,0
Potential advantages and hazards of transvaginal intratubal insemination and single-dose MTX for ectopic pregnancy are discussed.,0
Histopathology of the thyroid in amiodarone-induced hypothyroidism.,1
"The physiology and pharmacology of erection are reviewed, and pharmacologic treatment options and surgical treatments are reviewed.",0
"In this case, an evaluation for organism-specific pathology led to early identification of a potentially curable large bowel lesion.",0
Antibiotic therapy consisting of Amoxicillin and Gentamycin was given for seven days.,0
Visual hallucinations after intravitreal injection of bevacizumab in vascular age-related macular degeneration.,1
Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.,1
Massive plasmocytosis due to methimazole-induced bone marrow toxicity.,1
"Flare of Kaposi's sarcoma (KS) is well described in immunosuppressed patients treated with corticosteroids and rituximab, but has not yet been reported during treatment with imatinib.",1
BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.,1
"In each instance, the plasma thrombosis-inducing activity (TIA) appeared one to three days after chemotherapy and subsided subsequently.",0
"Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.",1
In this case senna was likely the cause of a subacute cholestatic hepatitis exemplifying again the potential role of herbal related liver injury.,1
"However, our patient was later found to have re-activation tuberculosis after long-term treatment.",0
"Serum aluminum levels were significantly (P less than 0.001) higher in these 3 infants and in 1 other, all of whom received more than 100 mg of elemental aluminum per kilogram of body weight per day (mean +/- S.D., 371.0 +/- 178.9 ng per milliliter [13.75 +/- 6.6 mumol per liter] ) than they were in 8 older children with azotemia who were not undergoing dialysis and who received less than 100 mg of elemental aluminum per kilogram per day (27.0 +/- 18.6 ng per milliliter [1.0 +/- 0.68 mumol per liter] ), 7 such children who did not receive aluminum hydroxide (20.28 +/- 9.2 ng per milliliter [0.75 +/- 0.34 mumol per liter] ), and 16 children with normal renal function (21.04 +/- 4.9 ng per milliliter [0.78 +/- 0.18 mumol per liter] ).",0
We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.,1
Drug-induced interstitial nephritis in a child with idiopathic nephrotic syndrome.,0
"In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.",1
"We report a 5-year-old boy with CF who had a stricture of the hepatic flexure region with associated narrowing due to submucosal fibrosis of the transverse colon, secondary to high-lipase pancreatin therapy.",1
A 67-year-old man developed diarrhea shortly after a 10-day course of oral ampicillin.,1
The patient remained asymptomatic up to the diagnosis.,0
Nicotinic acid-induced fulminant hepatic failure.,1
Using a medical emergency team to manage anaphylactic shock.,0
"Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.",1
Spontaneous pneumothorax following chemotherapy for metastatic germ cell tumor: a case report.,0
"We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.",1
Diagnosis of pseudotumor cerebri was based on satisfaction of four criteria proposed by Ahlskog and O'Neill.,0
CONTEXT: Radiation recall has been described in the context of gemcitabine chemotherapy.,0
The purpose of this article was to provide a detailed review of the role of TNF-alpha in controlling hepatitis B viral infection and the clinical impact blockade might have on viral control.,0
"Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.",1
"Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature.",1
"This may indicate that the anticonvulsive drug affected the vermis and flocculonodular lobe much more than the hemisphere of cerebellum, or that the cerebellar system sign in verminal and flocculonodular lobe lesion and its connection is detected more easily than the hemispheric lesion with the aid of a neuro-otological examination.",0
CONCLUSIONS: The most rational approach to treating NMS entails a hierarchy of interventions determined by the severity and progression of symptoms.,0
"In a series of 104 cases of intentional or inadvertent use of zidovudine at differing gestations in pregnancy, there were eight spontaneous first trimester abortions, eight therapeutic terminations, and eight cases of fetal abnormality occurring among a total of 88 cases where the pregnancy progressed.",1
"Consequently, it is most appropriate to explain the possible side effects from misuse of lindane to each patient.",0
In 1984 alanine aminotransferase presented abnormal levels.,0
These effusions can be due to multiple causes with drugs being implicated as one of the etiological agents.,0
Haptic repositioning was performed in the right eye.,0
The most common hematologic SMNs are myelodysplasia (MDS) and acute myelogenous leukemia (AML).,0
"We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.",1
A case of gouty arthritis following percutaneous radiofrequency ablation for hepatocellular carcinoma.,0
The literature is reviewed and the treatment implications are discussed.,0
We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.,1
A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).,1
We describe the case of a 50-year-old woman with advanced non-small cell lung cancer who developed status epilepticus shortly after receiving cisplatin and gemcitabine chemotherapy.,1
Emerging school-based methodologies are discussed with recommendations for future efforts.,0
CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.,1
This case report illustrates the neurotoxicity unique to HDARAC.,1
A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.,1
Atrial fibrillation following methylprednisolone pulse therapy.,1
"A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.",1
Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.,1
Essential thrombocythemia is a clonal myeloproliferative disorder that causes thrombocytosis.,0
"The patient reported in this case differs significantly from the two cases reported in the literature because he had normal renal function, no previous exposure to ACE inhibitors, the reaction was of late onset, and the symptoms recurred.",0
Steroid diabetes experienced by the reported cases may be a marker for the onset of diabetes in their adulthood.,0
"We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.",1
"Here we describe another case of VOD occurring after LT, but in which the causative role was played by azathioprine.",1
OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.,1
Nocardiosis. A literature review with selected case reports in two dogs.,0
"Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.",1
Dipyrone is commonly found in the homes of families who are originally from areas where it is still lawfully marketed.,0
"We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.",1
Options for avoiding allegations of abandonment are proposed.,0
AIM: To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin).,1
Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.,1
He had been treated with oral cyclophosphamide for 13 years.,0
It is important to always review the medications the patient is taking and consider them as etiological culprits in any new symptom complex.,0
These syndromes are often undiagnosed or misdiagnosed and lead to unnecessary morbidity and noncompliance with recommended pharmacotherapy.,0
"Bronchoalveolar lavage (BAL) may be used to rule out infectious etiologies, and an increase in BAL fluid eosinophils is suggestive of drug-induced toxicity.",0
We report here a rare case of pleuropericarditis due to methotrexate.,1
"However, a Jarisch-Herxheimer reaction occurring in a patient receiving treatment for ocular syphilis can be serious, resulting in the rapid loss of vision.",0
"However, the magnitude of such false positivity has not been previously reported.",0
"In patients with metastatic disease who had high levels of gastrin, SMS treatment for 5 to 24 months did not inhibit tumor growth or decrease gastrin levels.",0
OBJECTIVE: Anastrozole is a selective aromatase inhibitor and is used for the hormonal treatment of postmenopausal breast cancer.,0
"In the early postoperative period, pulmonary thromboembolism was suspected and confirmed by lung perfusion scintigraphy which showed bilateral segmental and subsegmental perfusion defects.",0
"Bone marrow transplant nephropathy (BMTN) classically presents more than 100 days after transplantation as an acute nephritis with hypertension, azotaemia and anemia that usually results in end stage renal failure (ESRF).",0
Four previously reported cases with the same sequence of events are reviewed as well as cases of chronic myelogenous leukemia following chemotherapy alone.,0
A 66-year old woman with acute pancreatitis was admitted to our hospital with the complaint of epigastralgia radiating to both flanks for two months.,0
"An angiogram was performed, which demonstrated that the mass was fed by the branches from the right external carotid artery.",0
The complexity of this situation can generate an impaired consciousness in the patients.,0
"It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.",1
Three infants with supraventricular tachycardia and congestive cardiac failure were given verapamil intravenously.,0
Metabolic balance studies and rechallenge with hydrochlorothiazide were undertaken to investigate the mechanism of the thiazide-induced hyponatremia.,1
"We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.",1
Cyclophosphamide pneumonitis.,1
All patients who developed diarrhea after undergoing the cancer chemotherapy were examined to determine whether or not they were complicated by C difficile colitis.,0
Metoclopramide hydrochloride (Reglan) is a widely prescribed drug for treatment of upper gastrointestinal symptoms.,0
Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy.,1
"The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.",1
There are few reports of salvage chemotherapy for HIV-related non-Hodgkin's lymphoma (NHL).,0
Early data identifies atomoxetine's influence on Tourette symptomatology to be not merely equivocal but potentially suppressive in the manifestation of tics.,0
METHODS: A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation.,1
Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.,1
Symptoms and laboratory findings improved after zafirlukast was removed.,0
"Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects.",1
"According to the Naranjo adverse drug reaction probability scale, the likelihood that temozolomide was responsible for the adverse drug reaction of fever was probable (score of 6).",1
"Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs.",0
"Specifically, after initiation of 500 mg MMF twice a day given in conjunction with the long-standing use of prednisone, which had been tapered to a dose of 10 mg daily, the patient's red blood cell count dropped by 17% over 7 weeks.",0
Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.,1
There is direct and indirect evidence for various immunologic and nonimmunologic pathways precipitating the reaction.,0
"Ocular examinations revealed intraocular pressure (IOP) of 30 mmHg under medication, dense posterior subcapsular opacity of lens, pale disc with advanced cupping, and marked constriction of visual field.",0
"The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.",1
"Surgical treatment included debridement (6), grafting (2), digit amputation (1), digit dermotomy (1), and fasciotomy (1).",0
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
Visual acuity had improved to 20/30(+2) O.D. and 20/30 O.S.,0
"Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems.",1
We report a case of Ritalin-associated cataract and glaucoma.,1
OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.,1
Despite drug withdrawal there was evidence of persistent airways obstruction and bronchial hyperreactivity.,0
Fulminant hepatic failure developed in a 24-year-old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism.,1
"Myeloma screen was negative; ANC >1,000 at day +7, platelets >50,000 at day +24.",0
"DISCUSSION: AIDS and cryptococcal meningitis, both of which the patient had, can potentially cause seizures.",0
RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.,1
Esophageal candidiasis following omeprazole therapy: a report of two cases.,1
"Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.",1
"Six days after she received a prescription for a 5-day course of azithromycin, her INR was 15.16.",0
"We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.",1
We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone.,1
The risks of sumatriptan administration in patients with unrecognized subarachnoid haemorrhage (SAH).,0
"Administration of excessive insulin induced hypoglycemia within 4 to 8 hours, followed by rebound hyperglycemia.",1
"Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.",1
This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD.,1
We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid.,1
"Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.",1
There was minimum toxicity reported for either of the arms and no treatment related deaths.,0
Her symptoms soon alleviated and serum lipase level declined.,0
Postdural puncture cerebral spinal fluid (CSF) leak most often manifests as a postdural puncture headache (PDPH).,0
The patient began her prescribed radiation therapy and 5-fluorouracil radio-sensitizing chemotherapy.,0
Subsequent observation revealed the presence of choreiform movements.,0
Hepatotoxic effects in a child receiving valproate and carnitine.,1
Mean duration of therapy was 5.5 yrs.,0
Troglitazone-induced fulminant hepatic failure.,1
Tumors were assessed for immunohistochemical evidence of mTORC1 activation and genetic evidence of alterations in TSC1 and TSC2.,0
"Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.",1
Rapid manifestation of cervical vertebral osteomyelitis.,0
"Course of ovarian hyperstimulation syndrome in 19 intact twin pregnancies after assisted reproduction techniques, with a case report of severe thromboembolism.",0
Otolaryngologists should be made aware of a newer cause of nasal septal perforations resulting from the more recent antiangiogenic therapy used to treat malignancies.,0
We report the case of an adult patient with acute lymphoblastic leukemia who presented with repeated transient ischemic attacks followed by a seizure during consolidation treatment with L-asparaginase.,1
Patients with cancer are especially vulnerable to the development of hyper- and hypocalcemia.,0
Four case reports presenting new acquisitions on the association between breast and endometrial carcinoma.,0
Intradermal testing with a wide range of steroid preparations gave positive results to prednisone.,0
Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).,1
"After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.",1
Possible mechanisms and preventive measures are discussed.,0
The possible underlying electrophysiological mechanisms of this phenomenon are discussed in this paper.,0
"Treatments can be given on an outpatient basis, without requiring prolonged patient sedation or immobilization.",0
A 64-year-old man with open-angle glaucoma had used topically applied epinephrine for 13 years.,0
In two patients opportunistic infections did not develop.,0
Halothane hepatitis and prompt resolution with methionine therapy: case report.,1
Nineteen cases of unusual enhanced vincristine neurotoxicity related to itraconazole have been reported in children.,1
Medical myths occur for many different reasons.,0
"Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.",1
"Quinine and its isomer quinidine are well-known causes of iatrogenic hypoglycaemia, due to excessive insulin secretion.",1
Fatal overdoses associated with quetiapine.,0
"We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.",1
"The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.",1
"We describe a case of soft tissue infection caused by Fusarium species in a heart-liver transplant recipient, and review the cases of fusarial infection reported among solid-organ transplant (SOT) recipients.",0
Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.,1
"Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.",1
"It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.",1
A case of a 53-year-old man who developed acute pneumonitis after bleomycin and moderate oxygen administration is presented.,1
Autoimmune hepatitis associated with the use of black cohosh: a case study.,0
Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.,1
All patients underwent radiological investigation for tumour staging and comparison with the following study in accordance with the protocol in place at our Department of Oncology and Division of Diagnostic Imaging.,0
"The patient developed neurologic signs and symptoms including disorientation, oculomotor defects, ataxia and multifocal myoclonus during both attempts at HAI.",0
"Because the cerebellar toxicity may be worsened by continuation of therapy after initial onset of symptoms, prompt termination of HDARAC is recommended.",1
CONCLUSION: It is possible that pseudophakic eyes that develop intense conjunctival hyperemia associated with ocular hypotensive lipids might be at higher risk for developing cystoid macula edema.,0
Skin necrosis after extravasation of low-dose vasopressin administered for septic shock.,1
"Follow up, at six months, after stopping the course of treatment, patient was asymptomatic except for slight bilateral non-tender breast enlargement.",0
"Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.",1
OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.,1
"Upon presenting to the primary care service a year and a half later, the patient was taking 40 mg per day of olanzapine and had gained 62 pounds, a 30% increase in body weight; glycosylated hemoglobin (A1c) was 11.1%.",0
RESULTS: A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria.,1
"PURPOSE: We examined an 82-year-old woman with delayed-onset endophthalmitis caused by an opportunistic pathogen, Ovadendron sulphureo-ochraceum.",0
"The overall toxicity is substantially less than standard induction chemotherapy, with the notable exception of deaths attributed to the development of pulmonary leukostasis coinciding with a rapid increase in the number of mature neutrophils.",0
The concentrations of quetiapine in these cases are 6-16 times greater than the upper reported therapeutic range (0.1-1.0 mg/L).,0
The only recent change in their treatment was the introduction or increased dosage of zonisamide.,0
"The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.",1
Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.,1
The anterior mediastinum was closed with an omental flap that was allowed to epithelize spontaneously.,0
The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.,1
The lesions were morphologically distinct and differed in their anatomical distribution during each episode.,0
"Both developed acute erythroid leukemia, 98 and 71 months after the original diagnosis of myeloma, and died of subarachnoid hemorrhage and cardiac arrest.",0
"However, the occurrence and management of akathisia induced by fluvoxamine have not been described.",1
Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.,1
A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.,1
We report a case of demyelinating disease occurring in a patient treated for psoriasis.,0
"FDE from cephalosporins has been rarely reported, and to the best of our knowledge there is no published report of ceftriaxone-induced FDE in the literature.",1
"Due to refractory elevations of ICP, high-dose pentobarbital infusion was initiated, and ICP gradually normalised.",0
Our report suggests the efficacy of PES as ACAD treatment of the unprotected LMCA.,0
Chest x-ray and thorax computed tomography revealed bilateral hilar masses and nodular infiltrations in the lung parenchyma.,0
Jude Medical mitral valve prosthesis.,0
Fungal arthritis and osteomyelitis are rare and documented mainly in immunocompromised or neutropenic patients.,0
INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.,1
Vancomycin-induced vasculitis.,1
"To date, this is the first reported case of what appears to be isolated thrombocytopenia associated with lansoprazole.",1
"Skin prick testing several weeks later identified diamorphine as the likely causative agent, a drug overlooked initially as a potential cause.",0
INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).,1
"Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.",1
"After 46 days of treatment, radiography showed cortical hyperostosis of the long bones.",0
"In ten cases (4.3%), radiology showed damage to the alveolar interstitium typical of inflammatory forms, whereas in the remaining three (1.3%) it depicted nodular opacities, which required differentiation between lung metastases and septic emboli.",0
Delayed recognition of intrathecal methotrexate overdose.,0
Lidocaine (a sodium channel blocker) serves as an antiepilepsy drug in neonates.,0
"Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported.",1
"OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.",1
DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.,1
Respiratory function tests were useful in the diagnosis of the interstitial abnormality and in monitoring response to prednisone.,0
"Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.",1
"Treatment was discontinued; the patient was managed with monitored IV hydration and loop diuretics, high dose corticosteroids and fresh frozen plasma infusions and recovered completely.",0
"INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.",1
We believe this to be a previously unreported complication.,0
The patient was otherwise healthy and taking no medication.,0
Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.,1
Antibiotic lock technique.,0
Treatment of the underlying cause and supportive care constitute the basic principles of management of disseminated intravascular coagulation.,0
We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.,1
Primary central nervous system lymphoma in a patient treated with natalizumab.,1
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.,1
Giant right atrial thrombi treated with thrombolysis.,0
A 55- year-old man had been followed for chronic hepatitis B infection for 10 years at another institution.,0
Isoniazid induced gynaecomastia: a case report.,1
"Treatment was given as direct observed therapy (DOT) and sputum cultures, blood chemistry and neurologic examination were undertaken on a regular basis.",0
This was felt to be primarily induced by doxorubicin.,0
"We describe a Caucasian child who initially presented with clinical and histopathologic features consistent with inflammatory bowel disease, for whom additional investigations led to the diagnosis of severe chronic active Epstein-Barr virus infection.",0
"At that time, MMI was discontinued and the patient was started on broad-spectrum antibiotics, dexamethasone, and G-CSF.",0
Transient TRH deficiency after prolonged thyroid hormone therapy.,0
Neuroleptic malignant syndrome due to risperidone treatment in a child with Joubert syndrome.,1
"Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.",1
"Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.",1
We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.,1
PURPOSE: To describe 2 cases of sterile corneal ulcers that persisted after several weeks of therapy with topical moxifloxacin 0.5% but that resolved when antibiotic therapy was changed.,0
"However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.",1
"CASE: A nulliparous woman with a long history of intrauterine contraceptive device (IUD) and recent Papanicolaou smear findings consistent with the presence of actinomyces presented with chronic vague lower abdominal pain, weight loss, poor appetite, and recent increase in abdominal girth associated with a large immobile pelvic mass.",0
CASE PRESENTATION: A 46-year-old man consulted his doctor due to symptoms of depression.,0
"Exposure of the fetus to indomethacin by administration of the drug to the mother may cause many side effects, including premature closure of the ductus arteriosus.",1
"However, 9 months later, while still asymptomatic, routine physical examination revealed a recurrent right lower quadrant tumor.",0
"After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.",1
London: Hodder Arnold; 2009).,0
Possible risk of invasive pulmonary aspergillosis with marijuana use during chemotherapy for small cell lung cancer.,0
The phenytoin only modified the IgA levels.,0
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
"He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.",1
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.,1
"A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy.",1
This report describes the first case of insulin-induced cardiac failure in a patient without underlying heart disease.,1
"An analysis of our patients, together with literature review of similar cases, suggests that the duration of chemotherapy may have been the most important factor in the leukemogenesis.",0
"In addition, his overall medical status worsened, as he developed concurrent acute renal failure and became more confused and lethargic.",0
A case of noncardiogenic pulmonary edema by ethanolamine oleate.,1
A 24- to 48-h course of large-dose glucocorticoid therapy is often used in the acute management of spinal cord injury.,0
Can propofol precipitate pancreatitis in patients with Cushing's syndrome?,1
We describe a case of PRES in a patient with collapsing focal glomeruloesclerosis (collapsing FGS) with complete recovery after withdrawal of cyclosporine (CSA).,1
"This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.",1
No major safety issues were observed during the study.,0
"The fingernails were more affected than the toenails and clinically the changes consisted of absence of lunulae, longitudinal ridging, transverse or longitudinal defects of the nailplate and a tendency of onychoschizia.",0
It is proposed that neuroleptic-induced dysphoric responses may be responsible for therapeutic failure in some cases of psychotic depression.,0
"Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.",1
"We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.",1
Reciprocal chromosomal translocations involving the MLL gene at chromosome region 11q23 are recurring cytogenetic abnormalities in both de novo and therapy-related acute myeloid leukemia (AML) and in acute lymphoblastic leukemia.,0
Crosslinking for post-LASIK corneal ectasia may induce DLK.,0
Pancreatic stones in 30 patients not treated with trimethadione neither disappeared nor diminished spontaneously.,0
"However, 3 months after withdrawal of treatment, the patient still showed clinical and laboratory symptoms of systemic lupus erythematosus.",0
Hemolytic uremic syndrome (HUS) is a rare complication following solid organ transplantation.,0
"ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.",1
DISCUSSION: It is not uncommon to confuse drug allergy with JHR.,0
Acute gastrointestinal bleeding following aortic valve replacement in a patient with Heyde's sindrome.,0
"In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate.",1
"A left L1 transforaminal approach was successful, and 1 mL of iopamidol (Isovue) contrast was injected, followed by 5 mL of a solution of 0.125% bupivacaine and 40 mg of triamcinolone.",0
"As a result of this and other evidence, the investigation of the adoptive parents was terminated.",0
"Magnetic resonance imaging revealed focal abnormalities, predominantly in the cortex, that on light and electron microscopic examination were demonstrated to be highly localized areas of neuronal loss, gliosis, and secondary Wallerian degeneration with paramyxovirus inclusions in the oligodendrocytes and surviving neurons.",0
The patient's hematocrit eventually stabilized and was 30% at discharge.,0
Case report and review of the literature.,0
At the time of deterioration all three had reduced HIV viraemia and increased CD4 cell counts.,0
FINDINGS: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression.,1
RESULTS: In one patient the rifampin-impregnated shunt system was implanted after external drainage to prevent further infection.,0
"TSH levels were normalised with the addition of mouse serum to the patient's sample, confirming the presence of human anti-mouse antibodies as the interfering substance in the TSH assay.",0
"The authors report five cases of tremor related to itraconazole therapy, which occurred within 1-12 months of initiating treatment and resolved gradually following itraconazole withdrawal.",1
Minoxidil is a potent antihypertensive agent used in the treatment of resistant hypertension.,0
Anaphylactic reaction to recombinant insulin-like growth factor-I.,1
The manner of death was determined to be accidental.,0
Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.,1
The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.,1
A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching.,1
Anxiety dreams and night terrors have been reported as complications of single-dose bedtime administration of both tricyclic antidepressants and neuroleptics.,0
Pegylated liposomal doxorubicin (PLD) is a chemotherapeutic agent used in the treatment of solid tumors.,0
OBJECTIVES: A delayed stroke-like leukoencephalopathy has been observed in patients receiving methotrexate (MTX) for childhood leukemia.,1
"Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.",1
Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.,1
We report three cases of patients who developed leukopenia during olanzapine treatment.,1
We report a case of a bullous lichenoid eruption due to the intake of captopril.,1
"The rash progressed to TEN in 7 days, and she was transferred to a burn treatment center.",0
Duodenal ulceration: a complication of tolazoline therapy.,1
Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).,1
"However, EO-induced noncardiogenic pulmonary edema has not been reported in human.",1
We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.,1
"Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.",1
They continued to rise for five more days before salicylate hepatotoxicity was suspected.,1
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
METHODS: Tissue obtained during vitrectomy was cultured and examined by light and electron microscopy.,0
Human immunodeficiency virus-1 viral load and antibodies were also negative.,0
Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.,1
"Five patients took a combination of herbs and presented with jaundice, fatigue and pruritus.",0
"A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.",1
"SETTING: Medical intensive care unit at the University of Chicago, Chicago, IL.",0
Resonance Imaging of LS spine showed an and was managed successfully with antibiotics.,0
Rifampicin-induced renal failure.,1
Tacrolimus (FK506)-induced mutism after liver transplant.,1
We discuss 2 recent cases seen at our institution and 39 cases described in the English-language literature since 1995.,0
"None had previously recognized acquired causes of QT, prolongation.",0
"Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.",1
"Subsequently, the patient presented with a lower eyelid mass, which on excision was demonstrated to be a chalazion.",0
"We describe a renal transplant recipient infected with Pneumocystis carinii pneumonia (PCP) who developed hypercalcemia, elevated 1,25-dihydroxyvitamin D, and suppressed parathyroid hormone levels.",0
"There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma.",0
The second case depicts acute CNS toxicity with known fatal potential.,0
"He was diagnosed with a viral syndrome, acetaminophen was prescribed, and he was sent home.",0
"Other causes of liver failure, such as viral hepatitis, autoimmune hepatitis, toxins, and heart failure, were excluded by appropriate diagnostic means.",0
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
Treatment of silastic catheter-induced central vein septic thrombophlebitis.,0
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
"The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.",1
"A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.",1
The patient reported herein strengthens the association between the 22q11.2 deletion spectrum and Evans syndrome.,0
"MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis.",1
"A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.",1
"Differentiation and treatment can be complex, especially when features of both syndromes are present and the patient has taken both serotonergic and neuroleptic agents.",0
We conclude that low-dose HU therapy in patients with thalassemia intermedia may increase total Hb levels sufficiently to eliminate the need for transfusions.,1
Case study: adverse response to clonidine.,1
"On indirect laryngoscopy, hyperadduction of the vocal folds was not the cause of the upper airway obstruction.",0
"Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.",1
Our experience supports hemodialysis for ESRF patients with atenolol toxicity.,1
CONCLUSION: Celiac disease must be ruled out in patients with malabsorption complaints in or after interferon (or pegylated interferon) therapy.,0
Inadvertent substitution of acetohexamide for acetozolamide.,0
"We suggest that nicotinic acid was the cause of his liver disease, that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure, and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity.",1
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.,1
This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.,1
"Proposed mechanisms include von Willebrand Factor abnormalities, decreased prostacyclin production, and immune complex formation.",0
Our study presents a new aspect of the benefit of STN stimulation with regard to drug-induced non-motor symptoms in patient with PD.,0
The efficacy of corticosteroid therapy in the treatment of eosinophilia has not been clearly established.,0
There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.,1
No relationship between amisulpride and rhabdomyolysis was found.,0
Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.,1
"We present a retrospective analysis of 4 HSCT recipients who survived long-term artificial respiration subsequent to pulmonary mycosis, and compare our current findings with historic data.",0
Ciprofloxacin is one drug that has been reported to cause interstitial nephritis.,1
A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis.,1
"Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.",1
The history of desmopressin use was not obtained at that time.,0
We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.,1
"BACKGROUND: Cutaneous manifestations of cryofibrinogenemia include purpura, ecchymosis, and ulcerations.",0
Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.,1
The patient was successfully treated by anticoagulant therapy.,0
We report a case of pulmonary toxoplasmosis after heart transplant despite the prophylactic anti-toxoplasmic treatment that was given but was not sufficient to prevent toxoplasmosis.,0
"It draws the clinician's attention to unusual susceptibility to extrapyramidal side effects and suggests that if a child shows this type of susceptibility to one neuroleptic, he/she may react similarly to other neuroleptics as well.",0
Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids.,0
"Two months following LASIK, an epithelial dendritic lesion appeared in the lower third of the corneal flap of the left eye with vesiculoulcerative lesions of the lateral side of the tip of the nose.",0
"RESULTS: Recurrences in both eyes were successfully treated with a combination of hexamidine and neomycin, and with polyhexamethylene biguanide respectively.",0
Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.,1
"Their plasma cell dyscrasias were evaluated with immunofixation electrophoresis of serum and urine specimens, quantitative serum lgs, and immunohistochemical staining of bone marrow biopsy specimens.",0
The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.,1
"The mean CYP2D6 activity is lower in Oriental than in Caucasian populations, because of a frequent mutation causing decreased enzyme activity.",0
These signs resolved 24-48 h after cyclosporin and ganciclovir were discontinued.,0
Anatomic arterial variation of the hand can lead to atypical presentation.,0
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.,1
"However, the extremely rare occurrence of complications related to perforation of the bladder can be detrimental.",0
This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.,1
Imidazoline intoxication in children.,1
CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.,1
"Although she was born after vacuum delivery and a scalp swelling was noticed from the third day of life, this swelling disappeared completely at the age of 3 months.",0
"At further evaluation, HBsAg was positive but serological work up was compatible with a healthy-carrier status.",0
"The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.",1
Anaphylaxis to cisplatin is an infrequent life-threatening complication which may occur even in patients who have received prior treatment with cisplatin.,1
"Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.",1
"BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.",1
The ECG remained normal.,0
"Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine ""hypersensitivity."" When schistocytes are present it is frequently termed ""quinine-associated TTP/HUS."" A severe deficiency of the vWF-cleaving protease, ADAMTS13, is associated with idiopathic TTP.",1
"CONCLUSIONS: Patients most commonly affected by ICD, such as pathologic gambling and hypersexuality, are males who develop PD at a younger age, and those with a previous history of mood disorder, alcohol abuse, or obsessive-compulsive disorder.",0
"In May 1999, the patient came to our polyclinic with edema of the feet and legs.",0
Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.,1
"PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.",1
It is stressed that ethambutol may act as a trigger factor to the toxic effects of Rifampicin.,0
"Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.",1
"Because of serious side effects of an increase in the QT interval causing torsades de pointes, dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting.",1
The attending or consulting physicians assessed that acute hemolysis or DIC caused or contributed to each death.,0
"A previously asymptomatic 62-year-old man with a history of hypertension and stable coronary artery disease developed paresthesias and fascicular and ventricular tachycardia after ingestion of an Ayurveda bowel regimen containing substrates from the Aconitum species, which is a known neurotoxin and cardiotoxin.",0
The lesions resolved after treatment with topical steroids and also oral allopurinol in one of the cases.,0
Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia.,1
"Computed tomography (CT) of the brain showed only mild right-sided hydrocephalus, and was negative for intracranial hemorrhage and intracranial mass.",0
"A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.",1
7. The vast majority of patients reported in the literature with ANLL complicating underlying malignancies have received cytotoxic drugs for prolonged periods (median 3 1/2 years) and leukemia developed most commonly 3 to 5 years after the diagnosis of the underlying disease.,0
"This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.",1
"This deleterious association, if verified, has important implications for the treatment of AMI in patients who have RA and are corticosteroid dependent.",0
"In the present study, we present three cases in which patients with resistant schizophrenia and comorbid alcohol use disorder were given lamotrigine to augment clozapine.",0
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.,1
The patient expired from cachexia three months later.,0
"Additionally, danazol produces hepatocellular damage in approximately 10% of women.",1
He had priapism following the use of olanzapine.,1
"This paper reports on a 6.9-year-old autistic male who developed repeated episodes of acute dystonic reactions associated with pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration.",1
"RESULTS: Similar to previous findings of drug-induced vortex keratopathy, atovaquone vortex keratopathy is presumably caused by its lipophilic properties.",1
Cytogenetic studies revealed an abnormal karyotype with deletion of the long arm of chromosome 11 (11q21) and 2 additional copies of the MLL gene attached to the short arms of chromosome 10 in 80% of the metaphase cells examined.,0
Early replacement therapy is recommended when proximal renal tubular abnormalities are detected to help prevent and control the severe metabolic bone disease associated with the Fanconi syndrome.,0
Discontinuation of dalteparin on day 4 led to resolution of symptoms.,0
"In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.",1
CMV antigenemia became negative within 2 weeks and never developed again.,0
"Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.",1
Gynaecomastia due to anti-tubercular chemotherapy is a rare side effect.,0
These findings suggest that GL might inhibit HIV-1 replication in vivo.,0
Rhodococcus equi pulmonary-central nervous system syndrome: brain abscess in a patient on high-dose steroids--a case report and review of the literature.,0
The reported frequency in young children varies (1-4).,0
"The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.",1
"Electromyography, muscle biopsy, and the course of the patient's illness were consistent with polymyositis.",0
"This report describes the initial protocol, the gingivectomy, and a 2-year follow-up.",0
"DISCUSSION: Reactions associated with arylamine sulfonamide-containing antibiotics have been commonly reported; however, cross-reactions with non-arylamine sulfonamide-containing medications have been rare.",0
"Side effects such as acute renal failure, hyperkalemia, gastritis, gastrointestinal bleeding, and asthmatic exacerbation, although rare, have been previously reported.",0
"BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.",1
Subacromial impingement syndrome as a consequence of botulinum therapy to the upper trapezii: a case report.,0
"While she was receiving the maximum dose of 180 mg/day of cinacalcet HCl and PTH at 443 pg/mL, she needed to be hospitalized for a right hip prothesis.",0
"However, in instances of spontaneous TLS complicated by the normally low glomerular filtration rate in the newborn infant, the use of rasburicase and other supportive care measures may still be inadequate, warranting further study.",0
All 3 patients experienced fairly typical chest pain syndromes and experienced elevations of cardiac enzymes consistent with myocardial ischemia.,0
Pirmenol hydrochloride-induced QT prolongation and T wave inversion on electrocardiogram during treatment for symptomatic atrial fibrillation.,1
Amphotericin B-induced seizures in a patient with AIDS.,1
"There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.",1
"Anti-tuberculous drugs, including ethambutol, were initiated at our clinic because the period between the ethambutol therapy and visual loss was too short and the dose of ethambutol was not very high.",0
The possible mechanisms of this leukopenia are discussed.,0
Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.,1
BACKGROUND: A 56-year-old man with normal cardiac function received treatment with interferon alpha-2b for malignant melanoma.,0
Treatment of total hyphema with relatively low-dose tissue plasminogen activator.,0
"The major problems affecting compliance with pharmacotherapy for schizophrenia are outlined here showing, by means of case histories, how sertindole has benefited schizophrenic patients.",0
We describe two cases that illustrate the use of lithium in the treatment of veterans with PTSD who complained of serious problems with irritability or angry outbursts.,1
She admitted that she often induced the episode herself and derived pleasure out of it.,0
"Renal failure appeared 8 to 17 days after beginning gentamicin therapy and was characterized by creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria.",1
Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.,1
One had a mildly abnormal electro-oculogram.,0
"In all the patients, pellagra symptoms appeared during isoniazid therapy.",1
The dermatology literature heretofore has not noted that anemia is a side effect of patients taking MMF to treat pemphigus.,1
"The patient was treated with octreotide 20 mg, at monthly interval.",0
"Histological examination revealed hyphae and arthrospores in the hair follicles and in the dermis with a diffuse dermal infiltrate consisting of lymphoplasmacytic cells, and focal collections of epithelioid cells, neutrophils and mild interstitial edema.",0
Affected patients may demonstrate a pattern of self-escalation of dopaminergic medication dosing which may lead to a state of dependency.,0
Graft-versus-host disease was seen only in 41% of the bone marrow recipients.,0
Lenalidomide is an important contemporary treatment option for patients with multiple myeloma (MM).,0
Surgeons and physicians should therefore be aware of the potential for RTA to occur with FK506 after any organ transplantation.,1
The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.,1
"Broncho-pulmonary infection in a 50-year-old male with acute, hypertensive, intracerebral bleeding, necessitated therapy with cefpirome (2 g/day, 6 days), ciprofloxacin (800 mg/d, 11 days) and tazobactam/piperacillin (9 g/day, 11 days).",0
PURPOSE: A case of carbamazepine-induced hyperammonemia is presented.,1
BACKGROUND: Bleeding is the most serious complication of oral anticoagulant therapy used for the prevention of thromboembolic complications.,0
"Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.",1
Lichen nitidus is an uncommon dermatosis of unknown etiology.,0
"A group of six patients, three with malignant melanoma, two with basal cell carcinoma, and one with metastatic adenocarcinoma, were enrolled in the study.",0
"In three other patients, adenosine was associated with prolonged bradyasystole and hypotension.",0
"Thalidomide neuropathy is often associated with proximal weakness and may progress even after discontinuation of treatment, in the phenomenon of 'coasting'.",1
"Four years after the beginning of IFN therapy, he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody, and then 28 units/day of insulin injection was started.",1
Case report: acute renal failure after administering intravenous immunoglobulin.,1
Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.,1
"She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.",1
The addition of intrathecal methotrexate to treatment protocols has increased survival rates in children with acute lymphoblastic leukemia but is also associated with varying degrees of neurotoxicity.,1
A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.,1
A spinal-cord injury can alter every aspect of a victim's life.,0
"The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.",1
She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.,1
"Recent reports have shown that Decadron (dexamethasone; Merck Sharp & Dohme, West Point, Pa) has a significant antiemetic effect on cisplatin-induced vomiting.",1
Therapy was adjusted as required on the basis of BCG sensitivity results.,0
Transient hemiparesis caused by phenytoin toxicity.,1
"The leukoencephalopathy, documented clinically and by CT and EEG, cleared after 2350 mg of leucovorin (citrovorum factor, folinic acid) was given in addition to the 135 mg given as part of the therapy.",0
Taxane-induced glaucoma.,1
"While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.",1
Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors.,1
"She had been taking nabumetone for 6 months, but had discontinued the agent 2 weeks before admission due to progressive edema.",1
We report a patient who developed adult respiratory distress syndrome (ARDS) secondary to Mycobacterium tuberculosis as an immune reconstitution disease.,0
"The clinical symptoms of both may be similar, and their clinical courses may be monophasic or multiphasic, mild but also very aggressive.",0
A lethal complication of peripheral vein vasopressin infusion.,1
We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.,1
"Bronchial exposure to alternative sprays containing beclomethasone dipropionate (group D), fluticasone-17- propionate (D) and dexamethasone-21-isonicotinate (C) was well tolerated.",0
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
"To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.",1
"The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.",1
Hypogammaglobulinemia associated with gold therapy: evidence for a partial maturation blockade of B cells.,1
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia.,1
Valvular heart disease in a patient taking benfluorex.,1
RESULTS: The mean age was 44 years (range: 23-67) and no sexual predisposition was noted.,0
Acute dystonia induced by lamivudine.,1
He recovered well and was able to walk by postoperative day 4.,0
A number of patients also had acute gastrointestinal hemorrhage.,0
Three nephrotic patients who had reduced renal function and active renal disease with progressive deterioration of renal function prior to the use of MP developed transient renal failure following an MP pulse therapy.,1
A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.,1
"Over a 36-hour period, insulin was progressively decreased and finally stopped because of the rapid fall and normalization of blood glucose concentration.",0
Fibrin sheath formation and chemotherapy extravasation: a case report.,0
"After delivery, clearance rapidly returns to preconception levels, enhancing the risk of adverse reactions in both mothers and breast-fed infants if the dose is not sufficiently reduced.",0
Effectiveness of pentostatin (2'-deoxycoformycin) in refractory lymphoid neoplasms.,0
"UFT, a combination of uracil and tegafur, is a second-generation anticancer agent.",0
A diagnosis of pustular psoriasis was made clinically and histologically.,0
A patient who developed necrotizing pancreatitis after transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is presented.,0
We report a case of HCL in a 66-year-old male treated with 2-deoxycoformycin.,0
We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.,1
"Blebitis, early endophthalmitis, and late endophthalmitis after glaucoma-filtering surgery.",0
"Of the eight patients in clinical trials, five had cardiovascular abnormalities and two had acquired immunodeficiency syndrome-related pneumonia.",0
Nat Rev Cancer 2002;2:124-132).,0
"Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol.",1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
Overnight sleep studies and multiple sleep latency testing were carried out under double-blind administration of either L-dopa or placebo.,0
"A significant feature of this group is its resistance to almost all presently available antibiotics including penicillin, the cephalosporins, and the aminoglycosides.",0
"We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.",1
The induction of hypoglycaemia with PAS in this patient suggests a potential role for PAS in the treatment of diabetes mellitus.,1
Fixed drug eruption (FDE) is an unusual type of cutaneous adverse drug reaction that is characterized by recurrent site-specific lesions each time the drug responsible is taken.,0
"During the first day of infusion, she began having severe shortness of breath.",0
DISCUSSION: Several different agents are currently available to provide effective anticoagulation in patients who have immune- mediated HIT.,0
Albendazole-induced pseudomembranous colitis.,1
Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.,1
A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.,1
OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.,1
Four of 5 chronic hemo- or peritoneal dialysis patients also received multiple antibiotics.,0
A 47-year-old male patient developed sepsis and monoarticular arthritis following autologous stem cell transplantation for recurrent Hodgkin's disease.,0
"Symptoms are usually considered nonspecific, and gastroscopy with biopsy is usually performed to establish the diagnosis.",0
"Because of the presence of hemolysis, the patient underwent testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency, for which he tested positive.",0
Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.,1
"The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.",1
All the lesions showed high attenuation relative to muscle on the precontrast CT and showed positive findings on PET/CT.,0
He quit smoking after 1 week of therapy and remained smoke free for the next 17 days.,0
"In this report, two cases of ET which evolved into AL without prior exposure to radiation or alkylating agents, and which were treated with long-term hydroxyurea therapy, are described.",1
OBJECTIVES: The improvement of pre-existing inflammatory bowel disease after orthotopic liver transplant might be anticipated.,0
Post-radiation necrosis of the larynx is a major complication after irradiation and has become rare.,0
"In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.",1
"The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.",1
Occurrence in mycosis fungoides treated with psoralens plus long-wave ultraviolet radiation.,0
"Cutaneous infection is rare and about 71 cases have been described, mainly in Europe in immunocompromised hosts.",0
CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.,1
L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.,1
(It is no longer contained in Correctol.),0
"CONCLUSION: WE and thiamine deficiency should be considered in all patients with malabsorption, malnutrition, and malignancies.",0
Myoclonic twitching in the lower limbs of a patient who received intrathecal narcotics is described.,0
Sudden reversible vitritis after keratoprosthesis: an immune phenomenon?,0
Bronchospasm induced by cardiopulmonary bypass.,0
We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.,1
"In addition, the in vivo immunological study also revealed an intercellular fluorescence, similar to that seen in pemphigus.",0
Switching patients from olanzapine SOT to olanzapine ODT treatment resulted in significant weight loss that was maintained during 12 months in both case reports.,0
Results: Four of the aviators continued on active duty for years.,0
"It has been associated with phenytoin, cyclosporine, and calcium channel blocking agents.",0
The combination of GM-CSF to accelerate hematological recovery and the possibility of administering large doses of a liposomal form of Amphotericin B were the contributing factors to the resolution of the infection.,0
We report the first case of IHA associated with cefuroxime administration.,1
"In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.",1
"No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.",1
On day four he was noted to have complete right sided femoral and left sided lateral femoral cutaneous nerve of thigh neuropathies.,0
A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.,1
Sarcoma complicating therapy with cyclophosphamide.,1
Even in typical cases PPG is often misdiagnosed and therefore wrongly treated; the unknown aetiology makes treatment difficult.,0
A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl).,1
"In addition, patients should be closely monitored for a possible delayed interaction that may occur with each repeated cycle of 5-fluorouracil chemotherapy.",0
"We report a 45-year-old Chinese man with CML and chronic hepatitis B virus infection, on imatinib treatment, presenting with herpetic rash and acute liver failure.",1
A case of a 53-year-old man who developed acute pneumonitis after bleomycin and moderate oxygen administration is presented.,1
Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.,1
"Multiple foci of axonal degeneration and demyelination were found in the optic nerves and chiasm, the superficial layers of the brainstem, and spinal cord and to some extent in other cranial nerves and spinal nerve roots.",0
Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.,1
Life-threatening hyponatremia caused by vinblastine.,1
"The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.",1
A patient with chronic myelomonocytic leukemia developed drug-induced pulmonary toxicity after using low dose oral etoposide.,1
Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.,1
"Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.",1
"We report that these tumors frequently express the CD-20 antigen, and immunotherapy directed at this antigen may be a well-tolerated and effective treatment.",0
"The first patient was supported by the use of a paracorporeal air-driven left ventricular assist device of the NCVC type, and had a moderate degree of renal and hepatic dysfunction at the time of transplantation.",0
We experienced 2 cases of mequitazine-induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems.,1
Endogenous pneumococcal endophthalmitis after splenectomy: report of two cases.,0
"OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.",1
"This observation suggest that linezolid is a promising drug for the treatment of prosthetic joint infections due to MRSA or other Gram-positive pathogens, particularly when other therapeutic approaches are not feasible or a long-term antibiotic therapy is required.",0
Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.,1
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
Growth hormone deficiency after localized ganglioneuroblastoma: A case report.,0
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.,1
Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta.,1
"In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.",1
"Shortly after chemotherapy and an injection of pegfilgrastim, the patient developed poorly defined, rapidly progressive erythema, edema, and pain in his right forearm.",1
The natural history of this condition is resolution without sequelae after appropriate therapeutic intervention for the vena cava thrombosis.,0
A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.,1
CONCLUSIONS: Clarithromycin may be a cause of fulminant liver failure either alone or by inhibiting the metabolism of other drugs.,1
CONTEXT: Acute pancreatitis has been reported in a few cases treated with macrolides or glucocorticoids.,0
A moderate vitreous hemorrhage occurred four days after PDT.,0
Phenytoin toxicity due to concomitant antituberculosis therapy.,1
In two patients clozapine was reinstated after risperidone was discontinued; serum triglyceride levels increased.,1
They discuss related literature reports of mania or rapid cycling after adjunctive estrogen administration for refractory depression.,0
"However, the child vomited when a cumulative dose of 315 mg was reached.",0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.",1
Severe autologous GVHD occurred only in patients transplanted for multiple myeloma and was observed at a much higher frequency in patients undergoing their second HPCT.,0
A 73-year-old woman on topical pilocarpine and adrenaline for chronic simple glaucoma for three years presented with a mass in the medial canthus of the right eye.,0
The risk of cardiac decompensation in infants with supraventricular tachycardia and congestive cardiac failure should be kept in mind prior to administration of verapamil.,1
"Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.",1
Drug poisoning was suspected on the basis of persistent tachycardia in the absence of other signs of dehydration.,0
"Reviewing our experience with 19 cases of male breast cancer, we found two patients with a 12-year history of estrogen therapy for prostatic carcinoma.",0
A 16-year-old girl with refractory AML received unmanipulated BMT from an unrelated donor.,0
Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.,1
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.,1
"One month later recurrence appeared in the right eye, as a central corneal infiltrate in the graft.",0
"INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.",1
The clinical and electrophysiological features of the case are discussed.,0
"PATIENT: A 46-yr-old female with ventilator-dependent, proliferative-phase acute respiratory distress syndrome complicated by Pseudomonas aeruginosa bacteremia and sepsis.",0
The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.,1
It represents one of the few documented cases of delayed clearance of echovirus in the cerebrospinal fluid in a patient with normal serum immunoglobulins.,0
We present findings from three patients who experienced a psoriasiform eruption apparently due to the antiepileptic agents sodium valproate and carbamazepine.,1
One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.,1
Fatal agranulocytosis: the use of olanzapine in a patient with schizophrenia and myelodysplasia.,0
The unusually though potentially life-threatening possibility of heart failure secondary to anti-TNF use in ankylosing spondylitis merits attention.,0
"RESULTS: A woman with a >15-year history of ovarian cancer experienced severe neurotoxicity (peripheral neuropathy, hearing loss), underwent aggressive resection of asymptomatic and long-standing metastatic disease in the liver (with tumor recurrence <1 year after surgery), and subsequently died of secondary acute leukemia.",0
Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.,1
Two fatal cases of poisoning by paracetamol are described.,1
"DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.",1
We present a case of sotalol-induced bradycardia reversed by glucagon.,1
A search of MEDLINE (1966 to November 1998) and International Pharmaceutical Abstracts (1970 to November 1998) did not reveal a similar case.,0
"Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.",1
Reversal reaction to Hansen's disease.,0
"The manufacturer began a Pregnancy Prevention Program (PPP) in 1988; however, exposed pregnancies continue to occur.",0
RESULTS: Discontinuation of corticotherapy led to anatomic and visual improvement.,0
"When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.",1
"The attributable mortality rate is 15%, with the most significant factor being treatment delay (mean time from presentation to initiation of treatment, 6.74 weeks).",0
Introduction of etanercept was also clinically effective but followed by development of severe heart failure.,1
Sixteen of 33 patients developed significant hyponatremia and hypoosmolality during oral treatment with lorcainide.,1
"On the second day of hospitalization, it was noted that the patient's dyspnea and sinus bradycardia could be related to a recent increase in his timolol dosage.",1
Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.,1
We reviewed the literature pertaining the management of pelvic actinomycosis.,0
"In the 27 late cases, Streptococcus species and gram-negative organisms comprised 48% of isolates; of 33 cases of endophthalmitis, 15 (45%) demonstrated no growth on vitreous culture.",0
"Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as ""retinoic acid syndrome."" This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.",1
"Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.",1
METHODS: We performed a retrospective review of ICD procedures performed at a single academic center and identified all ICD-related infections managed between 1983 and 2005.,0
"NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.",1
"The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).",1
He was diagnosed in the early post transplant period after anti-rejection therapy.,0
"DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.",1
"Despite continued improvements in mortality associated with a spinal-cord injury, until recently little progress had been made in improving neurologic function.",0
The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.,1
"Typically, it occurs in a patient with preexisting structural heart disease (20 of 24 [83%]) and often with some form of recent dental infection or manipulation (18 of 24 [75%]).",0
"Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.",1
Discontinuation of the statin improved his symptoms.,0
Her carbamazepine concentration decreased from 11.8 to 8.5 micrograms/mL; she also became pregnant at that time.,0
Here we reported the case of a liver transplant recipient with de novo HBV infection who had a favorable outcome after lamivudine (LAM) and adefovir dipivoxil (ADV) antiviral therapy.,0
"PURPOSE: The purpose of this report is to emphasise the role of the Acute Pain Service in managing local anaesthetic epidural infusions for postoperative pain management, the importance of vigilant monitoring, and to offer some guidelines to using local anaesthetic epidural infusions.",0
"We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.",1
"We concluded that the brief quiescent phase (second biopsy specimen) was characterized by retention of immunoglobulin to produce Russell bodies, and that the active phases of the disease were marked by migration of mast cells into the epithelium and by the presence of eosinophils and basophils in the substantia propria.",0
"Two children with leukemia developed PTE, the first during the relapse for acute lymphoblastic leukemia and the second at the onset of acute promyelocytic leukemia.",0
Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).,1
Somatostatin analogues are safe and generally well tolerated.,0
A 78-year-old man with a long history of major depression responded well to a course of ECT but relapsed before maintenance treatments could be started.,0
Ocular symptoms began between 3 and 6 months after transplantation.,0
"The urine revealed inappropriately high levels of magnesium and potassium despite critically low serum levels, with an appropriately low urine calcium level.",0
Stent-grafts were constructed from Z stents covered with polyester fabric and were delivered remotely through a catheter under fluoroscopic guidance.,0
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
A 17-year-old epileptic was admitted to the hospital in a confused state.,0
Paraneoplastic systemic sclerosis (SSc) occurs in about 3%-7% of individuals with SSc.,0
Priapism associated with trazodone therapy: case report.,1
"The remaining two patients were alive and well at median follow-up of 24 months (range, 4-25 months).",0
Disseminated muscular cysticercosis with myositis induced by praziquantel therapy.,1
A magnetic resonance imaging scan obtained 7 weeks after the injection showed a full-thickness tear of the supraspinatus tendon.,0
Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine.,1
"Candida sepsis developed during central total parenteral nutrition, at the age of 76 days.",0
Prolonged requirement for ventilatory support in a patient with Eskalith overdose.,0
"The elimination half-time (15 h) was similar to that reported for end-stage renal disease patients, while the steady-state volume of distribution (85 l) and the area under the curve concentration (127 mg/l.h) were greater.",0
"This methodology provides the decision analyst with a procedure to evaluate the outcome of specification uncertainty, in many decision problems, without resorting to Monte Carlo analysis.",0
Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.,1
The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.,1
This confirmed the history of captopril-related asthma.,1
Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.,1
"Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.",1
These questions are considered in the context of currently available literature.,0
Philadelphia chromosome-positive acute lymphoblastic leukemia secondary to chemoradiotherapy for Ewing sarcoma.,0
Intracameral tPA injection resulted in complete resolution of hyphema in all 3 eyes.,0
"However, alkylating agents overwhelmingly predominate as the class of compounds which are most often associated with terminal ANLL.",0
Contact allergy towards this reagent and 2 of its reaction products was proven by patch tests.,0
"A rare case of malignant osteopetrosis in a 19-year-old girl, who presented with the complication of osteomyelitis of the mandible following tooth extraction, is presented.",0
"Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.",1
"C. striatum should be recognized as a potential pathogen in both immunocompromised and normal hosts in the appropriate circumstances, and appropriate antimicrobial therapy can quickly lead to resolution of infection.",0
"It has been recently approved for the treatment of multiple myeloma, an incurable plasma cell tumour that accounts for 10-15% of all haematologic malignancies and for approximately 20% of deaths.",0
"Although haloperidol was discontinued, no further hallucinations or delusions occurred.",0
"He developed hypertension in April 1989, underwent a final chelation, and retired.",0
"The mechanism of the decrease in plasma potassium induced by phosphate treatment was investigated in a 24-year-old hypertensive patient with hypophosphatemic osteomalacia, who was the youngest of four patients, belonging to a 23 number kindred of five generations.",1
Neisseria sicca peritonitis in a patient maintained on chronic peritoneal dialysis.,0
"Ethambutol is frequently used in the treatment of tuberculosis, and, although optic neuropathies have been reported with the use of ethambutol, this adverse side effect has been considered to be rare and generally reversible with discontinuation of the medication.",1
"Type I, blue-black pigmentation confined to sites of scarring or inflammation on the face; Type II, blue-grey circumscribed pigmentation of normal skin of the lower legs and forearms; and Type III, diffuse muddy brown pigmentation of normal skin accentuated in sun-exposed areas.",0
Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.,1
5: Movement disorders I: parkinsonism and the akinetic-rigid syndromes.,0
A 68-year-old female patient with advanced ovarian carcinoma collapsed whilst receiving a carboplatin and cyclophosphamide infusion.,1
Abscesses of the pterygopalatine fossa are extremely rare.,0
"Treatment with topical and intracameral amphotericin B and systemic fluconazole, along with topical corticosteroids and intracameral t-PA, was successful in eradicating the corneal infiltrate and resolving intraocular inflammation.",0
Mediastinal extravasation of doxorubicin.,0
We discuss a variety of bronchopulmonary complications of IBD and their association with sulfasalazine.,1
Risperidone-induced obsessive-compulsive symptoms in two children.,1
BACKGROUND: Coagulation disorders can cause intracerebral bleeding that may be difficult to detect since subsequent aberrant clot formation may mask early detection.,0
Venlafaxine-induced urinary incontinence resolved after switching to sertraline.,1
Transient acute myopia resulting from isotretinoin (accutane) therapy.,1
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.,1
A causal relationship between the administration of halothane and clinical improvement is suggested.,0
Minimally invasive repair of a left ventricular pseudoaneurysm after surgical patch reconstruction of an infarct-related free posterior wall rupture: CT-guided intervention.,0
"Although follow-up is short, radiotherapy alone appears to provide excellent disease-free survival.",0
"The effect of varying concentrations of dextrose on the histamine content of the blood of normal, allergic, non-diabetic and diabetic, and non-allergic patients was studied.",0
"Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.",1
A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.,1
This clinical management may offer an alternative to treatment suspension.,0
"The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.",1
METHODS: A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.,1
We present the case of a 58-year-old woman who ingested more than 35 g of caffeine in a suicide attempt.,1
The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.,1
Most new drug therapies require randomized data to show effects before widespread use and acceptance occur.,0
Insulin-induced lipohypertrophy: report of a case with histopathology.,1
"She was admitted following a fall and, after being given metoclopramide, developed movement disorder and a period of unresponsiveness.",1
PURPOSE: We report a case of a patient who developed a postoperative anterior spinal artery syndrome that was masked by the use of epidural analgesia.,0
We also review the literature describing the spectrum of clinical findings due to intraocular blastomycosis.,0
Cardiorespiratory toxicity due to miconazole.,1
"A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",1
Zonisamide is a broad-spectrum antiepileptic drug used to treat various types of seizures.,0
Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.,1
TREATMENT/OUTCOME: Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.,1
"The patient was well on routine follow-up at the outpatient clinic, with no progression of lymphoma or interstitial pneumonitis.",0
Nephrotic syndrome in a multiple sclerosis patient treated with interferon beta 1a.,1
We suggest that colonoscopy and biopsy should always be performed if other causes of diarrhea have been excluded.,0
The reports of this tragic event in the media horrified a mother in another province.,0
Patient had seizures and developed failure.,0
"Two of the four patients with pseudomembranous colitis did not promptly respond to therapy, and all four suffered significant further immobilization because of the disease.",0
Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.,1
Clinicians frequently encounter patients who present with borderline personality disorder (BPD) and prolonged and/or pronounced psychotic symptoms of an atypical nature.,0
The dark-adaptation curves were normal for one patient several months after isotretinoin therapy was discontinued.,0
Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.,1
Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.,1
Clinicians should be aware of the possibility of psychotic symptoms with the use of this agent.,0
The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.,1
A causal relationship between high doses of thyroid hormone and the presumptive impairment of endogenous TRH reserve is suggested.,0
Aortic perforation complicating carcinoma of the oesophagus is extremely uncommon.,0
A 16-month-old male presented to the Emergency Department cyanotic and short of breath after ingestion of a hair-care-equipment cleaning solution.,0
Differentiation between recurrent tumor and radiation necrosis in a child with anaplastic ependymoma after chemotherapy and radiation therapy.,0
The fifth patient exhibited paraesthesia and agitation caused by olanzapine that was misdiagnosed as psychotic agitation.,1
Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery.,0
This case illustrates that PCR is a rapid technique for the early diagnosis of TA-GVHD.,0
A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.,1
"Aminoglutethimide was discontinued until completion of radiotherapy, and the rash resolved.",1
A hemagglutinin mutation (198 Thr-->Ile) reduced the virus affinity for receptors found on susceptible human cells.,0
"Amoxapine, a new antidepressant, appears in human milk.",0
"The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.",1
A patient who had been treated with large doses of thyroid hormone for several years developed features of secondary hypothyroidism after thyroid hormone withdrawal.,1
"This case illustrates the potential diversity of clinical lesions in a single patient with NEH, and its response to systemically administered corticosteroids.",0
"Six months following cessation of therapy, the ERG was still abnormal for one patient, but continued improvement was evident at 25 months; for the second patient, the ERG was normal at one year.",0
"The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.",1
"Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.",1
The patient's medications had been stable for at least six months except for the addition of carbamazepine one month before his arrival at the ED.,0
Large dose of methylphenidate may cause cataract and glaucoma.,1
"Consequently, the treatment was immediately stopped.",0
Cerebral manifestations of ergotism.,0
A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.,1
Steroid creams applied topically to the skin are routinely used in the treatment of many dermatoses.,0
Falling backward in two elderly patients taking bupropion.,1
Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.,1
"Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.",1
"Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.",1
"A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.",1
Previously noted abnormal signal intensities have nearly disappreared on follow-up MRI obtained on the 22nd day after the first seizure.,0
"We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.",1
"This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.",1
Terbinafine-induced cholestatic liver disease.,1
We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.,1
Pharmacologic doses of recombinant human erythropoietin in the treatment of myelodysplastic syndromes.,0
"The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.",1
This finding suggests a dopaminergic mechanism specifically in changing the frequency of cycling between depression and mania.,0
"The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.",1
"In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.",1
This patient adds to the growing literature of a second malignancy occurring after prolonged successful chemotherapy of a primary neoplasm.,0
"While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect.",1
"After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.",1
Exfoliative dermatitis secondary to tobramycin sulfate.,1
Acute septic arthritis in chronic osteonecrosis of the hip.,0
Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.,1
She was receiving chronic therapeutic doses of HCQ for the treatment of lupus erythematosus.,0
Brain biopsy in all three disclosed PML and marked perivascular lymphoplasmacytic infiltration.,0
"Ten hours after the second methotrexate injection, the patient experienced a diffuse pruritic papular eruption located mainly on the limbs.",1
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
"The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.",1
Pilocarpine toxicity and the treatment of xerostomia.,1
Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: a case report.,1
"Each dog developed arterial hypertension, with systolic, diastolic, and mean arterial pressures ranging from 170 to 205, 90 to 112, and 123 to 148 mm of Hg, respectively.",0
Hydroxyurea (HU) and sodium phenylbutyrate (SPB) have been shown to increase fetal hemoglobin (Hb F) levels in patients with thalassemia intermedia.,1
DISCUSSION: Serotonin syndrome is a potentially lethal pharmacodynamic interaction between medications that increase serotonergic transmission at the synaptic junction.,0
Pentazocine-induced fibrous myopathy and localized neuropathy.,1
This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.,1
"Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.",1
"Laboratory abnormalities included a prothrombin time < 10%, an international normalized ratio exceeding the laboratory limits, and an activated partial thromboplastin time >120 seconds.",0
The patient suffered a life-threatening anaphylactoid reaction to amifostine.,1
Two patients are described in whom subtle cognitive impairments are associated with therapeutic doses of amoxapine.,1
OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.,1
Systemic allergic contact dermatitis to 8-methoxypsoralen (8-MOP).,1
"Infarction and necrosis may be common and incite complications from parasitic vascular attachment, pain and thrombosis.",0
"Blood biochemistry revealed severe liver dysfunction, although no markers including hepatitis virus or autoantibodies associated with autoimmune liver diseases were detected.",0
Adenomyosis confined to the broad ligament is extremely rare.,0
"Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.",1
"The present report is of a 67-year-old woman presenting with bulky cervicothoracic RIF who, 10 years previously, had received radiochemotherapy for a small cell thyroid carcinoma to a dose of 50 Gy, with severe acute side-effects.",0
Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.,1
We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.,1
We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.,1
Acute renal failure is a rare complication following the administration of intravenous immunoglobulin (IVIG).,1
"This report emphasises the clinicopathological features and the diagnostic peculiarities of the acute tumour lysis syndrome, which occurs uncommonly in dogs.",0
CONCLUSION: This patient's neurological deficits were not due to the epidural analgesia.,0
CONCLUSION: Patients receiving inhaled morphine should be closely monitored and resuscitation equipment should be readily available.,0
"He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.",1
We report a case of NEH masquerading as cutaneous vasculitis in a woman receiving cyclophosphamide for lupus nephritis.,1
Acute pancreatitis associated with danazol treatment for endometriosis.,1
Three distinct types of minocycline-induced cutaneous pigmentation have been described.,1
None of the patients has clinical or radiologic findings suggestive of central pontine myelinolysis or akinetic mutism.,0
"The patient was treated surgically by foramen magnum decompression and occipito-cervical fusion, and by transoral resection of the clivus.",0
Focal segmental glomerulosclerosis in children with acute lymphocytic leukemia: case reports and review of literature.,0
"INTERVENTION: Volume resuscitation, vasopressors, high PEEP mechanical ventilation, paralysis, nitric oxide, steroids, rapid albumin infusion.",0
Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.,1
Clinicians should include phenolphthalein in their list of possible causes of drug-induced TEN.,1
"Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.",1
The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children.,0
We suspect that similar syndromes reflecting injury to the spinal cord injury may be unrecognized following surgical repair of coarctation.,0
OBJECTIVE: To report a case of rapidly occurring hyperglycemia that occurred in a geriatric patient 3 days after treatment with olanzapine.,1
The dog remains healthy despite the marked increase in the number of circulating platelets.,0
The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.,1
Sulfasalazine-induced lupus erythematosus.,1
Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness.,1
PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported.,1
"A woman 38-year-old, suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo-Medrol, developed a spastic paraparesis at the lower limbs.",1
"The patient displayed several characteristics of NMS during therapy with olanzapine, including fever, elevated creatine kinase level, leukocytosis, and mild muscle rigidity.",0
"He was started on oral lansoprazole 60 mg twice daily and, on hospital day 2, his platelet count decreased to 102 x 10(3)/mm(3); on hospital day 3, the platelet count was 36 x 10(3)/mm(3).",1
Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.,1
"Due to the severity of the rash, temozolomide was permanently discontinued.",1
"OBJECTIVE: Our purpose was to test the efficacy of stanozolol, a drug capable of fibrinolytic enhancement, in treating cutaneous ulcers caused by cryofibrinogenemia.",0
Lipoid pneumonia: a silent complication of mineral oil aspiration.,1
The nonnucleoside analog nevirapine is an inducer of cytochrome P450 3A4 liver metabolism and has interactions with protease inhibitors and oral contraceptives.,0
A biopsy specimen showed pleural and parenchymal fibrosis.,0
"However, this phenomenon has been largely limited to skin.",0
"The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.",1
Her clinical symptoms improved with discontinuation of pranlukast and administration of systemic corticosteroid.,0
"The remaining 12 received three or more courses of treatment, and three of these patients achieved a complete response.",0
Results at 3 months an open-prospectus study of 30 cases and review of the literature.,0
Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.,1
"We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.",1
CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.,1
The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.,1
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
"DISCUSSION: After exclusion of other causes, the onset of thrombocytopenia after administration of lansoprazole, the resolution of the adverse reaction after discontinuation of the drug, and the fact that no other medicines were introduced during this time frame lead us to believe that this was most likely an idiosyncratic thrombocytopenic response to lansoprazole.",1
"We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.",1
The massively obese patients had an increased risk of cancer and complications from therapy.,0
Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C.,1
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.,1
CONCLUSIONS: Most cases of pseudoporphyria are drug-induced.,0
"However, the history of prolonged veiling of the face by a cloth by the patient, perhaps contributing to the occurrence of lesions on face, is a point of dubious significance.",0
"Initial laboratory studies showed severe hypophosphatemia and elevated alkaline phosphatase and serum 1,25-dihydroxyvitamin D levels.",0
Hepatobiliary scans using Tc-IDA are reliable in making the diagnosis of acute cholecystitis.,0
"The literature on human aflatoxicosis shows that the presentation may be acute, subacute and chronic.",0
We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.,1
Can ketamine prescribed for pain cause damage to the urinary tract?,1
"In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.",1
"Experience in the current case suggests that preventive measures for tumor lysis syndrome, including allopurinol and hydration, should be taken for patients with high leukemia burden who receive imatinib therapy, and parameters of tumor lysis should be monitored in the early phase of therapy.",0
"Most patients can be successfully managed when patient and physician expectations are realistic and aligned, the selection of preventive medications is individualised, and the initiation and titration strategy is appropriate and carefully followed.",0
One should therefore be aware of possible extrapyramidal side effects with olanzapine that are reduced compared to classical neuroleptic drugs but not completely eliminated.,1
"This increase was mirrored by an improvement in seizures, but not in myoclonus or ataxia.",0
CASE SUMMARIES: Two patients who received ifosfamide-containing chemotherapy developed NCSE.,1
"In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.",1
Immediate postoperative cystogram and pelvic computed tomogram (CT) after the development of seizures demonstrated a fluid collection from the suprapubic catheter site into the anterior abdominal wall.,0
"C1-inhibitor deficiency, or hereditary angioedema, is a genetic disorder characterized by recurrent circumscribed, nonpruritic, nonpitting subepithelial edema.",0
"CASE REPORT: Forty years oriented old male, opium addict, was admitted to the ICU, with headache, nausea and abdominal pain, and weakness in his lower and upper extremities without definitive diagnosis.",0
The effect of SERMs on the endometrium.,0
Atypical necrotizing scleritis after strabismus surgery.,0
The purpose of this study was to evaluate the neuroprotective effect of MB in these patients and to review the literature.,0
"He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.",1
Intravenous injection of diazepam caused a rapid normalization of the EEG with disappearance of the clinical manifestations.,0
A case report.,0
A new type of minocycline-induced cutaneous hyperpigmentation.,1
The NZ Pharmacovigilance Centre has received 7 additional reports of severe infections in patients with RA taking leflunomide.,1
"Within two months, the ophthalmic abnormalities had resolved.",0
A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.,1
"Serial electroencephalograms were obtained to evaluate CHL central nervous toxicity, before, during and after treatment with this agent.",0
"The first neurological symptoms like paraesthesia, severe hyperpathia of the legs and mild to heavy spinal ataxia occurred after an average time of treatment of 78 days and a mean dosage of 52 g.",0
Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection.,1
Warfarin was discontinued and restarted at 7.5 mg/wk.,0
"Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.",1
There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.,1
Practicing gastroenterologists and intensivists alike need to be aware of the potential for serious pulmonary sequelae with the use of combination therapy for chronic hepatitis C viral (CHCV) infections.,0
OBJECTIVE: To report the clinical course of a woman with cryptococcal meningitis and no previous cardiac disease who developed a fatal cardiac arrhythmia after an acute overdose of amphotericin B and to review its toxicity.,1
"Multifocal osteonecrosis has a wide variety of etiologies, but is most often encountered in the clinical setting of corticosteroid administration, connective tissue disorders, transplantation, hemoglobinopathies and dysbarism.",0
"Lenalidomide is an immunomodulatory agent approved for use in patients with myelodysplastic syndrome, and in combination with dexamethasone for refractory or relapsed multiple myeloma.",0
Recurrent agranulocytosis induced by two different antithyroid agents.,0
We present the first case of ovarian endometrioid carcinoma and endometriosis in a postmenopausal patient who was treated with tamoxifen for breast cancer.,1
"We report on a patient who developed hypersensitivity pneumonitis during treatment with the beta-blocker, celiprolol.",1
"The patient recovered well, both cognitively and physically, and did not have any further symptoms in 1 year of follow-up.",0
A 5-year-old girl was diagnosed preB cell Acute Lymphoblastic Leukemia (ALL).,0
"A small dose of protamine sulphate was then administered, which promptly restored hemostasis.",0
"Because of the difficulty of case collection, understanding of the association of MAHA and anal squamous cell carcinoma remains vague.",0
Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.,1
Clinicians are advised to observe for symptoms of toxicity and to do serial blood levels to monitor this interaction.,0
Concomitant administration of lithium with olanzapine may place patients at risk for NMS.,1
"The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.",1
No other site of invasive aspergillosis was evident.,0
"Small doses of smoked cannabis may improve pain, mood and sleep in some patients with chronic pain.",0
Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.,1
"Historically, coagulation screening has not been routinely recommended after organophosphate intoxications.",0
"We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).",1
He received dimercaprol (BAL) and calcium disodium edetate (CaEDTA) for two five days session.,0
Phantom limb pain as a manifestation of paclitaxel neurotoxicity.,1
Treatment with itraconazole of widespread tinea corporis due to Trichophyton rubrum in a bone marrow transplant recipient.,0
"A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.",1
We present three clinical cases of clostridial orthopedic infection and review the related medical literature.,0
"Methotrexate may rarely provoke serositis, even with low doses and after just a few weeks of therapy.",1
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
"However, the effect of chemotherapy on cord tolerance is unclear.",0
CLINICAL FEATURES: The patient was a 22-yr-old obese man with metastatic testicular carcinoma who underwent a left-sided thoracoabdominal retroperitoneal tumour resection.,0
Leishmania infantum leishmaniasis in corticosteroid--treated patients.,1
The patient did well until developing a rapidly progressive lesion of the left neck.,0
CONCLUSIONS: The fundus picture shown in these cases may be typical of ASPPC after IVTA injection.,1
Torsade de pointes occuring due to a long QT interval is a rare but potentially fatal arrhythmia.,0
Neuroleptic malignant syndrome due to atypical neuroleptics: three episodes in one patient.,0
"A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.",1
Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.,1
Little attention has been paid to infertility in men with epilepsy and little information exists about the mechanisms by which anti-epileptic drugs affect spermatogenesis or sperm function.,0
"These side effects include agranulocytosis, seizures, and cardiorespiratory symptoms.",0
CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.,1
Cis-retinoic acid (RA) may further increase the risk of developing BMTN.,1
The resurgence of HBV DNA preceded the elevation of liver enzymes for 20 weeks.,0
Serum triglyceride levels of four patients with psychotic disorders were decreased after switching therapy from clozapine to risperidone.,0
"The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.",1
Infections with multi-resistant organisms such as methicillin-resistant Staphylococcus aureus in ventricular assist device recipients are often difficult to treat and present a high mortality rate.,0
"On two occasions, within 48 hours of treatment, the patient developed acute leukopenia.",0
"Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.",1
These perfusions gave a moderate or good temporary palliation as regards to tumor growths on the extremity.,0
A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.,1
"Initially, National Institutes of Health Stroke Scale score was 21, and 24 hours later it improved to 9.",0
Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.,1
"It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.",1
"Alkylating agents have a well established role in the treatment of malignant disease, with well documented side effects.",0
"A 32-year-old woman with lazy bladder was treated with cisapride (10 mg q.i.d.) for three weeks, obtaining a progressive improvement of the symptomatology and urodynamic parameters, and the return to pretreatment conditions after drug withdrawal.",0
"Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).",1
"The authors present a case report of a granulomatous reaction leading to urethral prolapse, 3 months after the transurethral injection of calcium hydroxylapatite.",1
"However, there may be a publication bias in some case reports and studies towards reporting successful rather than unsuccessful CPRs.",0
Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.,1
"Three cycles of chemotherapy had been administered without complications when, at the beginning of the fourth cycle, the patient developed clinical and laboratory abnormalities consistent with the development of the hemolytic-uremic syndrome.",0
"A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.",1
He has remained clinically stable for over 5 years.,0
Hypercalcemia occurs frequently after renal transplantation.,0
An adverse drug reaction (ADR) induced by fluoxetine was suspected and fluoxetine treatment was discontinued.,0
"Acetazolamide may have accelerated the development of osteomalacia by several mechanisms, including increased renal calcium excretion.",1
Pulmonary aspergillosis masquerading as progressive post-transplant lymphoma.,0
"Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.",1
Serum antidiuretic hormone (ADH) remained elevated at 0.59 pg/ml in spite of a significant reduction in serum osmolality to 254 mosm/kg.,0
Interference with smoking-cessation effects of varenicline after administration of immediate-release amphetamine-dextroamphetamine.,0
Progressive pulmonary fibrosis complicating cyclophosphamide therapy.,1
Previous successful treatment with one ACE inhibitor does not rule out the vasculitis caused by the drug from the same group.,0
Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.,1
"Cerebral infarcts in a pediatric patient secondary to phenylpropanolamine, a recalled medication.",1
"White, flocculent material was observed in the anterior chamber and 24 hours later this settled on the iris surface.",0
"A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.",1
We report a case of pregnancy in a woman exposed to ATRA during the first trimester.,0
"The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.",1
"In conclusion, intradermal skin tests can be a useful tool for detecting a potential cross-reaction between platinum salts.",0
"Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.",1
Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?,1
Prolonged severe cholestasis induced by oxacillin derivatives.,1
"BACKGROUND: Fluoxetine, a highly specific serotonin reuptake inhibitor, has been reported to cause sexual dysfunction in a minority of patients.",1
An indirect immunofluorescence test for ANCA was positive.,0
"In addition, cultures of specimens obtained at autopsy did not reveal a cause for the heart failure.",0
Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.,1
"He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.",1
A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.,1
We present the case of a 41-year-old male undergoing surgery for restenosis at the site of a repair.,0
A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.,1
Pharmacogenetics of antidepressants: clinical aspects.,0
Heavy proteinuria then developed and the drug was stopped.,0
"Cerebrospinal fluid smear showed the ie, Streptococcus agalactiae that grew on blood wound culture, sent at the time of admission.",0
Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.,1
"The absence of borderline mutations in the normal population, and the co-segregation of the expanded allele with neurological signs in one kindred suggest that SCA2 mutations may be responsible for a subset of familial parkinsonism.",0
SUMMARY OF BACKGROUND DATA: CPS has a risk of vertebral artery (VA) injury.,0
We report a case of acute hyperphosphatemia secondary to rectal administration of sodium phosphate and sodium biphosphate (Fleet enema).,1
This entity should be kept in mind when evaluating the acute abdomen in the HIV-positive patient.,0
It cannot be assumed that the development of a mediastinal mass or its persistence following chemotherapy is due to recurrent or residual disease.,0
In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.,1
"The paper discusses the imputability of benfluorex, a drug used as an adjuvant in hypercholesterolemia, structurally related to amphetamines.",0
"We report a case of biopsy-proven acute tubulointerstitial nephritis associated with a second course of flurbiprofen, a nonsteroidal anti-inflammatory drug of the propionic acid class.",1
Two patients had a history of schizophrenia.,0
Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity.,1
"The most progressive neurological deficits like severe tetraspastic paresis, were seen only in the nondialytic renal insufficient group (3 patients), while the others had a more benign course of the disease.",0
"This experience supports the hypothesis that heparin can be readministered early to patients with heparin-associated thrombocytopenia and thrombosis, provided antiplatelet therapy is given.",1
"The etiologies of the osteonecrosis in our study included corticosteroid therapy, sickle cell disease and one case of idiopathic osteonecrosis.",0
MEASUREMENTS AND MAIN RESULTS: A 37-yr-old female with recently diagnosed acute myelogenous leukemia was admitted to the ICU with mental status changes and progressive dyspnea requiring intubation and mechanical ventilation.,0
EEGs and Spect scan results were consistent with dysfunction in the left frontotemporoparietal regions of the brain.,0
CONCLUSIONS: Our experience indicates that safely flying with newly diagnosed DM type 1 is possible.,0
CASE REPORT: We present cases of 10 patients with Type 2 diabetes mellitus who developed acute renal failure and severe lactic acidosis.,0
"The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.",1
"Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.",1
Our case points to the need for increased awareness by the general pediatricians of the potential hazards of mineral oil use for chronic constipation.,1
"The possible pathophysiologic mechanisms for the adverse reactions include a single-drug effect, a pharmacodynamic interaction, and a pharmacokinetic interaction.",0
The histological findings of marked cholestasis without evidence of extrahepatic biliary obstruction or acute hepatitis were compatible with the diagnosis of drug-induced liver disease.,0
A medical evaluation for an alternative etiology of his seizures was negative.,0
Ceftriaxone-induced fixed drug eruption: first report.,1
"Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.",1
Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.,1
We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.,1
"Eleven consecutive JW adult patients with acute leukaemia, all of whom had been denied care in other institutions, were treated at the European Institute of Oncology (EIO) in Milan, Italy.",0
We wish to call for cautious approach at time of cessation of prolonged ACTH therapy because of possible unexpected and only partially understood hazardous side effects such as hyperkalemia.,1
"Eleven days after initiation of therapy with amiodarone, the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia.",1
At five years of age elevated serum and urinary androgen levels unsuppressible with dexamethasone were noted.,0
Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.,1
"The infant improved clinically under intravenous hydration therapy, nevertheless lithium serum levels increased again and we did not know for certain if our clinical instinct or the actual figures were correct.",0
This review is an in-depth report of the efficacy and safety of 1% lindane compared with the agents that have been preferred as alternative.,0
We suspect that nefazodone inhibits metabolism of tacrolimus.,1
Infection with Mycobacterium genavense in a patient with systemic lupus erythematosus.,0
She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.,1
"In previous reports, three of four patients with TSHoma displayed Graves' disease after tumor resection, and TSH is also known to play a major role in regulating immunomodulatory gene expression in thyrocytes.",0
"CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.",1
CASE REPORT: A 45-year-old woman had complicated Crohn's disease with multiple fistulae and only 1 m of residual small bowel.,0
"Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.",1
Computed Tomography was used to demonstrate the increased retro-orbital fat.,0
"To the best of our knowledge, this is the first report of 1,25-dihydroxyvitamin D-mediated hypercalcemia caused by PCP in a renal transplant recipient.",0
Any psychotropics of little clinical significance were then cautiously minimized.,0
Iatrogenic ergotism is the primary source of ergot intoxication.,0
Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.,1
"In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.",1
"Since recent studies have reported no negative interactions with concurrent use, we here report three cases (one case of a prolonged seizure, a serotonin syndrome and a focal seizure) of severe lithium-induced side effects while patients underwent ECT without complications and lithium serum levels were still subtherapeutic.",1
"All three patients had microcytic microchromic anemia with basophilic stippling of the erythrocytes, lead lines in X-ray of the knee joint and high blood lead levels.",0
Lichen planus and acne provoked by gold.,1
RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.,1
"Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.",1
DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.,1
"A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.",1
"Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.",1
"The pigment may be a drug metabolite-protein complex chelated with calcium, or an insoluble minocycline-melanin complex.",0
"Although a rechallenge was not tried, this case appears to demonstrate a temporal relationship between the initiation and discontinuation of metoclopramide and the onset and resolution of symptoms.",0
Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature.,1
A unique patient with adrenal insufficiency is reported who received corticosteroids intravenously and then had multiple lesions develop that were similar to focal lipoatrophy as known to occur secondary to faulty intradermal injections of corticosteroids.,0
Metformin-associated lactic acidosis (MALA) is a serious metabolic complication that occurs because of metformin accumulation in patients who become dehydrated or developed acute renal failure.,1
A drug interaction between zafirlukast and theophylline.,1
"Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.",1
"Ten days following adrenalectomy, watery diarrhea appeared.",0
It has also been advocated as an intervention for diagnostic use to assess uncommon types of tachycardia.,0
A case of barbiturate-induced submassive hepatic necrosis is presented and the literature is reviewed.,1
"The ophthalmological examination was normal, except for extensive bilateral maculopathy with shining crystalline deposits, central and peripheral visual field defects, slightly affected scotopic and photopic potentials in the flash-ERG, and an abnormal m-ERG.",0
At least three of these patients developed acute myelogenous leukemia (AML).,0
We report a patient with severe Crohn's disease and the short bowel syndrome on parenteral feeding who was not responding to conventional therapy and underwent treatment with cyclosporin (CyA) given initially intravenously and subsequently orally in each of two courses.,0
"The disease-modifying drugs he was taking, cyclosporin and methotrexate, were stopped, and the lymphoma resolved spontaneously without the use of chemotherapy.",1
"Although a single case, this report questions the safety of using an intraoperative application of mitomycin C for preventing a recurrence of pterygium.",0
The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain.,1
"We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.",1
"The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.",1
Persistent cerebrospinal fluid leak is a known complication of intrathecal pump system insertion for drug delivery.,0
Cytomegalovirus retinitis treated with ganciclovir in a renal transplant recipient.,0
Dumping syndrome is a sequel of gastric surgery in adults and Nissen fundoplication in children.,0
Nephropathy caused by methicillin therapy for staphylococcal septicemia.,1
"Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.",1
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
This case illustrates a potential risk associated with drug eluting stent and alerts clinicians to the life threatening risk of spasm when stenting multiple vessels with drug eluting stent (especially the Taxus stent).,0
Three relevant cases are reported and a review of the published literature is made.,0
A 73-year-old woman presented with fever and cough 2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL).,1
CASE SUMMARY: A 50-year-old white woman with a history of advanced breast cancer refractory to other treatment modalities was receiving vinorelbine.,0
"Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.",1
Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.,1
"All other factors, including laboratory data, dietary intake, activity level, and concurrent use of other medications, were stable and noncontributory.",0
To our knowledge no severe persistent neurological deficits following thrombolytic therapy have been reported.,0
"Following the improvement of the symptoms of SJS, he received alternate-day oral prednisolone without any cutaneous eruption.",0
Effects of esomeprazole on the pharmacokinetics of atazanavir and fosamprenavir in a patient with human immunodeficiency virus infection.,0
The following is a report of 2 cases of rifampicin-induced renal insufficiency.,1
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
"Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described.",1
Spindle coma in benzodiazepine toxicity: case report.,1
A retrospective review of TTP patients with quinine-associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed.,1
A Meckel diverticulum is an embryonic remnant of the vitellointestinal duct.,0
Two cases of sacroiliitis due to P. avidum have been reported.,0
Scleral buckling and pars plana vitrectomy reattached the retina.,0
"In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.",1
Carbamazepine-induced hyperammonemia.,1
Many organ systems may be affected.,0
"Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.",1
"A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",1
Renal biopsy showed acute interstitial nephritis with eosinophilic cells.,0
Infectious toxicity of dexamethasone during all remission-induction chemotherapy: report of two cases and literature review.,1
Case report: role of granulocyte colony stimulating factor in radiotherapy.,0
Bleomycin induced hyperpigmentation with yolk sac tumor.,1
Discontinuation of ergot-containing products and cessation of tobacco and caffeine use is the cornerstone of therapy in chronic ergot toxicity.,0
"The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.",1
"However, this class of drugs has been associated with tic exacerbations, thus limiting their utility in this patients subgroup.",0
This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.,1
We present a case of antisynthetase syndrome whose predominant feature was fibrosing alveolitis and which may have been drug-induced.,0
SUBSEQUENT COURSE: The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment.,1
"CASE SUMMARY: We report the case of a 31-year-old patient hospitalized due to behavioral alterations and treated with oral zuclopenthixol, an antipsychotic from the thioxanthene family, who developed an acute, painful erection.",1
"The course of this patient's renal disease contrasts sharply with diffuse proliferative glomerulonephritis of idiopathic systemic lupus, and suggests that this rare complication of procainamide therapy may have a favorable course.",0
Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.,1
Three patients with T315I abl-mutated chronic myeloid leukemia (CML) or Philadelphia chromosome (Ph)-positive acute lymphocytic leukemia (ALL) have achieved clinical responses to doses of MK-04547 that are not associated with adverse events.,0
"Symptoms and signs of augmentation were related to low plasma levodopa levels, abating 75 minutes after oral levodopa administration and reappearing after 3 hours, closely mirroring the rapid rise and fall of plasma levodopa concentration.",1
Abdominal examination and laboratory studies were not clinically remarkable.,0
"In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.",1
Discontinuation of MMF was followed by a rapid and spontaneous rise in neutrophils in two patients.,0
A new sodium homoeostasis was established with a higher dose of DDAVP.,0
"Cytogenetic analysis of the bone marrow cells at the time of diagnosis of t-MDS revealed a clonal abnormality; 46,XX,add(7)(p13), der(17)t(3;17)(p11;p13).",0
"Because most infections are late complications and have indolent onsets, a high level of clinical suspicion is required for early diagnosis.",0
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
Treatment with terbutaline was continued for 13 days and was well tolerated.,0
"Tocolysis was stopped immediately, and the laboratory data improved gradually.",0
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
These observations suggest that CPH82 has glucocorticoid receptor agonistic effects.,0
Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.,1
"However, it would be emphasized that the side-effects of the drugs could be considered as one of the etiologica factors causing the glial abnormality.",0
This case documents the first report in the otolaryngology literature describing this new etiology for nasal septal perforations.,0
"MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction.",0
OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review.,1
"A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.",1
Other upper tract neoplasms after cyclophosphamide are reviewed.,1
CONCLUSIONS: X maltophilia is a potential intraocular pathogen in an immunocompetent host.,0
"In this case, interferon alpha induced polymyositis and cardiomyopathy is diagnosed in a 33-yr-old male patient with history of chronic hepatitis B.",1
"Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.",1
"When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.",1
Histologically confirmed lymphoma with evidence of active EBV proliferation developed within cervical lymph nodes 3 weeks after his first autologous stem cell rescue.,0
"Acute lymphoblastic leukemia (ALL) is uncommon in this patient population, and Philadelphia chromosome positive (Ph+) ALL in particular, is rare.",0
Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.,1
Both cytoplasmic features of adaptation and nuclear alterations were noted in hepatocytes.,0
Depression is a common problem in elderly patients and frequently is treated with antidepressants.,0
We conclude that the currently available data do not indicate that thrombolysis contributes to a significant increase in bleeding complications when administered during CPR.,0
"With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.",1
"After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.",1
The second patient experienced mild nitritoid symptoms following several GSTM injections prior experiencing a cerebrovascular accident within several hours of her next injection.,1
METHODS: A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops.,1
"Vitamin D toxicity complicating the treatment of senile, postmenopausal, and glucocorticoid-induced osteoporosis.",0
Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction.,1
We report a 76-year-old man who developed an acute blistering eruption following high-dose penicillin treatment for pneumococcal septicaemia.,1
PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.,1
"The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.",1
One month later the patient remained symptom-free.,0
Controversy exists as to whether making a definitive diagnosis in these patients has an impact on overall outcome.,0
An oral multivitamin tablet was substituted instead.,0
Two patients developed hypersensitivity to nitrosourea compounds.,0
"The patient's blurred vision gradually improved, but visual field defect remained.",0
Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.,1
Continuing the treatment with 13-cis-retinoic acid without systemic steroid eventually cleared the systemic manifestations and skin lesions.,0
"Dose-intensive chemotherapy with intravenous melphalan and growth-factor-mobilized blood stem cell support is feasible therapy for patients with AL amyloidosis, even when there is clinical evidence of cardiac involvement.",0
We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.,1
"Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.",1
The events occurred approximately 10 days after the start of each chemotherapy course.,0
"These agents are increasingly associated with infections, particularly mycobacterial infections.",0
"A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",1
Cutaneous eruptions occur in 3% of individuals administered carbamazepine.,1
Immunoprecipitation analysis revealed a band with the molecular weight of the Band 3 anion channel only in the presence of the patient's serum and oxaliplatin.,0
The occurrence of this entity is linked to the presence of circulating leukoagglutinins.,0
OBJECTIVE: The objective of this study was to assess the efficacy of beta-blockade on clinically significant left ventricular outflow tract obstruction in premature infants treated with dexamethasone because of bronchopulmonary dysplasia.,0
Other related complications include decreased bone healing and inhibition of orthodontic tooth movement.,0
"BACKGROUND: It has been proposed that the innate immune system plays a central role in driving the autoimmune T-cell cascade leading to psoriasis; however, there is no direct evidence for this.",0
Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.,1
"A repeat provocation test, under antihistaminic cover , failed to produce similar response.",0
"Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.",1
The syndrome commonly presents with pruritus and increased muscle tone.,0
We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.,1
Infection of total hip prosthesis by Mycobacterium tuberculosis and Mycobacterium chelonae in a patient with rheumatoid arthritis.,0
"Diclofenac was immediately stopped, leading to a complete restoration of liver functions over the course of the next few months.",0
CBC revealed pancytopenia.,0
"Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.",1
Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.,1
"The first reported case, in an adult, of cholestyramine induced hyperchloremic metabolic acidosis is a 70 year old female with a two year history of primary biliary cirrhosis confirmed by histologic and immunologic criteria.",1
Nonoliguric acute renal failure after captopril therapy.,1
This is the first report of pulmonary hypertension in an adult patient during lithium therapy.,1
"BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.",1
Theophylline intoxication following viloxazine induced decrease in clearance.,1
Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.,1
Fatal stroke in migraine: a case report with autopsy findings.,0
The tinnitus is thought to be secondary to rhythmic involuntary movements of the soft palate.,0
A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.,1
We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.,1
"Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.",1
Obidoxime was reinstituted after the 9 d interruption and muscle strength improved with the first dose.,0
"CASE REPORT: A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigation the only precipitating factor found was an international normalised ratio of 4.8.",1
Pure red cell aplasia associated with fenoprofen.,1
Clinical and pathological responses of tumor and the side-effects were examined in these two groups.,0
Diagnosis of transfusion-associated graft-versus-host disease by polymerase chain reaction in fludarabine-treated B-chronic lymphocytic leukaemia.,0
"After cessation of chemotherapy, the pulmonary lesions resolved and all three patients sustained their remissions.",0
"Severe microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment were each noted in about 90% of the cases.",0
Unusual hypersensitivity to warfarin in a critically ill patient.,1
RESULTS: Budesonide use can cause contact dermatitis.,1
We report a 78-year-old man who had acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia.,1
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
"A week before the onset of hepatitis, the patient complained of upper gastrointestinal symptoms and was treated for gastritis.",0
"The case report illustrates the need for flexible individualized dosage schedules, similar to other neuroleptics.",0
"At this writing, few cases of nondurally based intradural meningioma have been reported.",0
"Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment.",1
"Clinical trials have shown that atypical drugs such as sertindole do not induce EPS, are effective against negative as well as positive symptoms and do not affect cognition.",0
"This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.",1
"In children, only a few cases with this complication have been reported.",0
Poorly controlled hypertension in a painter with chronic lead toxicity.,1
Ciprofloxacin-induced toxic epidermal necrolysis in a patient with systemic lupus erythematosus.,1
"We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.",1
Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate.,1
"CONCLUSIONS: Because blebitis may be prodromal to endophthalmitis, aggressive antimicrobial therapy, perhaps with oral quinolones, is warranted.",0
The routine immunologic studies were normal.,0
"However, we did not know of the previous tragedies nor had we fully understood how critical examination of some of our own earlier near misses could have made such a tragic mistake less likely to occur.",0
"He was diagnosed with acute pleuropericarditis by blood tests, electrocardiogram, chest X-ray, and echocardiogram.",0
Pedunculopontine nucleus stimulation induces monocular oscillopsia.,0
BACKGROUND: Cytomegalovirus (CMV) associated with thrombotic microangiopathy (TMA) in transplant patients has not been extensively described.,0
"Itraconazole can be administered as continuous dosing, 200 mg per day for 3 months, or in the form of pulse therapy, 200 mg twice a day for 1 week per month for 3 consecutive months.",0
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.,1
Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.,1
A literature search conducted to determine the mechanism behind the antagonism of this overdose showed that promethazine interacts with receptors in the central nervous system.,0
A 40-year-old woman presented with an unusual form of corneal herpetic reactivation 5 weeks after laser in situ keratomileusis.,0
"Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.",1
"In those patients who found the commercially available cream uncomfortable, a 1% clotrimazole suspension formulated in artificial tears was used and found to be well tolerated.",0
"In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.",1
Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.,1
Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports.,1
Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.,1
"Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.",1
Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.,1
"After excluding other causes of long QT syndrome, the HCQ was suspected as the cause of her ventricular tachycardia.",1
"Because of a hypersensitivity reaction, initial therapy with penicillin G and gentamicin was stopped and substituted with cefazolin.",1
Scleromyxedema is a dermatologic disorder associated with a monoclonal gammopathy and neurologic manifestations.,0
"However, the sphincterotomy did not improve cholestasis.",0
METHODS: Interventional case report and literature review.,0
This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.,1
"After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.",1
Mexiletine hydrochloride was useful in preventing recurrences of torsades de pointes.,0
"A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).",1
The introduction of para-aminosalicylic acid (PAS) led to hypoglycaemic coma.,1
A 59-y-old with a history of chronic renal failure on hemodialysis was diagnosed with herpes zoster and begun on 800 mg acyclovir 5 times daily.,0
A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.,1
ITO is a rare but curable tumor of the ovary using combination chemotherapy.,0
"We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.",1
"We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.",1
The case is unique in that it is the first reported ingestion of oral pilocarpine tablets and the first dosing error reported for this indication.,0
The patient was heterozygous for the factor V Leiden mutation.,0
"However, significant changes in vital signs (hyper- and hypotension) and cardiac conduction abnormalities were observed in a few patients, notably in elderly patients.",0
Myocardial ischemia associated with high-dose carmustine infusion.,1
The marked thrombocytosis was nonresponsive to hydroxyurea therapy.,0
Pigmentary aberrations are well known side effects of cytostatic chemotherapeutic agents.,0
The intent of the discussion is to alert physicians that the appearance of epiglottis can occur from causes other than infection and that a surgical airway should not be the first thought when such a case arises.,0
Reversible findings of restricted diffusion in 5-fluorouracil neurotoxicity.,1
Plasma exchange in selected patients with juvenile rheumatoid arthritis.,0
"On postoperative day 114, however, he was diagnosed with recurrent CMV infection.",0
The recombinant human IgG1 monoclonal antibody specific for human TNF-a adalimumab (Humira) has been recently introduced for the treatment of moderate/severe psoriasis.,0
"In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy.",1
In one case the central serous chorioretinopathy recurred 3 times during 3 separate courses of treatment.,0
Treatment with topical corticosteroids and avoidance of suspect irritants usually resolves the dermatitis.,0
Hypoalbuminemia and thrombocytopenia were observed at this time also.,0
"In lead intoxication, nerves may incur mechanical damage.",0
"Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or ""cutting"" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.",1
'Spontaneous' hypertensive episodes with monoamine oxidase inhibitors.,0
"Before retreatment, the best corrected visual acuity (BCVA) ranged from 20/40 to 20/200.",0
"Nevertheless, osteonecrosis of the jaw (ONJ) has been reported in some patients being treated with bisphosphonates.",0
We present a patient who had undergone renal transplantation referred for recurrent sinusitis.,0
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
"We suggest that nicotinic acid was the cause of his liver disease, that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure, and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity.",1
"Children undergoing chemotherapy, postsurgical procedures and those with AIDS are at increased risk for developing this unique type of shock.",0
"However, positive emission tomographic scanning revealed disease progression.",0
"Although pathologic confirmation of the cause was not possible, the potential for this alarming complication should be recognized by physicians prescribing epidural steroid therapy.",0
The markedly increased expression of fibrogenic factors PDGF-B and IGF-1 on hyperplastic alveolar macrophages and hyperplastic type II pneumocytes may play an important role in the fibrogenesis of this disease.,0
The patient had removed the hair from her axillae with wax 3 weeks before the development of the eruption.,0
"She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.",1
Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.,1
"DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.",1
"A case of fluoxetine induced seizures, in a person with Down syndrome, is described.",1
Objective antitumor responses and significant palliation of symptoms have been demonstrated.,0
One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.,1
We describe a case of subcutaneous metastasis along the needle track after percutaneous ethanol injection (PEI) for treatment of hepatocellular carcinoma.,1
"Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.",1
Reduced vision secondary to pigmented cellular membranes on silicone intraocular lenses.,0
"Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis, a patient developed acute renal failure.",1
"Although a few case reports link metronidazole with the development of pseudomembranous colitis, albendazole has not been associated with the development of this condition.",1
Medical treatment was continued for 6 mth.,0
Symptoms mimicking Crohn's disease deteriorated under intensified immunosuppression and surgery.,0
We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.,1
The case histories and comments on the diagnosis and management of pulmonary nodules are reviewed.,0
Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.,1
A comparison of the pharmacological actions of successful and unsuccessful treatments for AHC is made.,0
Cardiobacterium hominis endocarditis in a patient with a hypersensitivity reaction to penicillin.,0
Prompt diagnosis of WE is important because it is potentially fatal and readily treatable with thiamine supplementation.,0
Clinical and morphological features of gold neuropathy.,1
Medical treatment of a grossly enlarged adenomyotic uterus with the levonorgestrel-releasing intrauterine system.,0
"To our knowledge, this is the first case report that demonstrates the occurrence of fever with low-dose amifostine therapy without the manifestation of accompanying rash or hypotension.",1
"At postmortem examination, the characteristic microvascular lesions of the hemolytic-uremic syndrome were found in the kidneys.",0
Amoxapine-induced cognitive impairment in two patients.,1
"At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.",1
We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.,1
"The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.",1
"Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).",1
We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia.,1
Dermatitis to captopril.,1
We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.,1
RESULTS AND CONCLUSIONS: Clonazepam provided effective relief for > 6 months in two patients with shooting/shocking phantom limb pain.,0
Quetiapine-induced myoclonus.,1
"Although it is related to numerous risk factors, its etiology remains unclear.",0
The patient was treated with IFN-alpha in another medical center for 6 months because his liver biopsy showed chronic active hepatitis.,0
"DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.",1
"In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.",1
"The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin.",0
There had been one episode of chest discomfort in her past history.,0
"The infants in the other two reported cases also died, which suggests that TEN in early infancy has an extremely poor prognosis.",0
An increased incidence of different malignancies associated to chronic lymphocytic leukemia (CLL) has been reported.,0
"Its mode of anti-inflammatory actions in rheumatoid arthritis is not clearly understood, but modulation of neutrophil activity or inhibition of neutrophil inflammatory product formation or release appear to play a role.",0
"Beginning ductopenia was present in two, suggesting that itraconazole might be responsible for the occurrence of prolonged drug-induced cholangiopathy.",1
Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.,1
Lymphomatoid granulomatosis after immunosuppression for pemphigus.,0
This patient may have been at increased risk for this interaction secondary to his age and history of alcohol abuse.,0
"Acute occlusion of the popliteal artery, a limb-threatening complication, was reported after total knee arthroplasty.",0
"The stimulation indices of the drug-induced lymphocyte stimulation test (DLST) for AZA in these two patients were as high as 2,180% and 430%, respectively, but those of healthy volunteers were under 120% without nonspecific suppression of lymphocyte proliferation.",0
"Interestingly, the use of carboplatin (CBDCA) and VDS in the subsequent treatment course was well tolerated indicating that the SIADH was most likely to have been induced by administration of CDDP.",1
We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.,1
Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).,1
Fatal exacerbation of paraneoplastic systemic sclerosis after neoadjuvant chemotherapy in a breast cancer patient.,0
Intravenous diazepam exacerbated the seizures.,1
CONCLUSION: Serial amniocentesis may place patients at elevated risk for Candida chorioamnionitis and subsequent preterm delivery.,0
"However, in the rare case of postoperative patch leakage, a relapse of a pseudoaneurysm may occur.",0
Acute myocardial necrosis during administration of amsacrine.,1
We describe a patient with M4 AML treated with standard chemotherapy followed by G-CSF who developed marked monocytosis on day 8 of G-CSF therapy.,1
The treatments have been reasonably well tolerated with some acute skin toxicity.,0
Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.,1
Hyperphosphatemia is an infrequent complication of the tumor lysis following induction therapy for lymphoproliferative disorders that can result in acute renal failure.,0
"In the following days, fever, vomiting, hypertension and ARF occurred.",0
The possible mechanism is thought to be an allergic reaction to the drug.,0
Oculomotor disturbances associated with 5-fluorouracil chemotherapy.,1
"There is potential for this side effect, and additional caution in the use of this drug should be followed.",0
We report a case of an 11-year-old boy who experienced an anaphylactic reaction after administration of bacitracin ointment.,1
This case extends the spectrum of fludarabine pulmonary toxicity to include pulmonary nodules.,1
A case of oculogyric crisis induced by metoclopramide is described in this paper.,1
The possibility of severe rhabdomyolysis should be considered in a patient with water intoxication due to massive ingestion of caffeine-containing beverages.,1
Severe heparin associated thrombocytopenia is a rare complication of heparin therapy.,1
"The possibility of deep vein thrombosis caused by the compression of the veins by necrotic tumor should be considered in patients with abdominal or pelvic metastases of GIST, including patients treated with imatinib.",1
A complete clinical and laboratory recovery took place following withdrawal of drugs.,0
This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.,1
"We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.",1
He did not suffer from any allergy but drinking red wine caused vasomotor rhinitis.,0
RESULTS: The patient retained excellent visual acuity and the choroidal hemorrhage resolved completely within two months.,0
"However BUN and serum creatinine continued to increase and peaked on the following day at 8.6 mmol/l of urea (24 mg/dl) and 194 mumol/l (2.2 mg/ml), respectively.",0
Skin necrosis secondary to low-molecular weight heparin in a patient with antiphospholipid antibody syndrome.,1
"The overall symptomatology of these patients as rated on the Brief Psychiatric Rating Scale (BPRS) decreased significantly from a mean of 57.0 +/- 10.4 to a mean of 37.8 +/- 7.7 (t = 7.03, df = 14, P = .001).",0
"While the pathogenetic and clinical relationship between the different autoimmune-dysreactive complications is still unclear, and the supporting role of the frequent immunosuppressive treatment may add significantly to these risk factors, clinicians who are engaged in the management of these patients should be aware that multiple, concurrent or subsequent disorders might occur in these subjects, and also that severe infections might be of relevant concern.",0
Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.,1
Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.,1
Early discontinuation of anticonvulsants after neonatal seizures: a preliminary report.,0
"Endocrinologically speaking, three of them had ""Hashitoxicosis"", while the other had silent lymphocytic thyroiditis.",0
"No standard treatment has been established, but therapy must be prolonged, as relapses are common and can occur at the initial site or distant locations.",0
"The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.",1
"In one patient, disease was confined to the colon, while three patients had disease involving the terminal ileum and colon.",0
Acute leukopenia associated with silver sulfadiazine therapy.,1
Amiodarone induced torsades de pointe.,1
Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.,1
Awareness of this disease and need for prompt institution of therapy is stressed.,0
"We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.",1
"When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.",1
"After 2 months, antibiotic therapy was continued with one drug.",0
The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.,1
"The pseudolymphoma syndrome is a reversible reactive condition consisting of fever, lymphadenopathy and generalized rash.",0
"However, we successfully treated the patient with the antibiotics trimethoprim-sulfamethoxazole (TMP/SMX) and minocycline hydrochloride (MINO), and performed endotoxin-absorbing therapy using polymyxin B (PMX) to remove the endotoxin from Gram-negative bacillus as well as continuous hemodiafiltration (CHDF) to remove inflammatory cytokines.",0
Cefuroxime-induced immune hemolysis.,1
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.,1
Chlorpropamide-induced hemolytic anemia.,1
Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.,1
Topical hydroquinone is used in the treatment of a number of skin conditions.,0
"On days 2-6, the patient experienced a myocardial infarction, ischemic cerebrovascular accident, recurrent lower extremity arterial thrombus, and splenic infarct.",0
Dental and gingival pain as side effects of niacin therapy.,1
We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.,1
"Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred.",1
Hypoglycaemia did not recur despite continued treatment.,0
"Over the next several months, she continued to require supplemental calcium, magnesium, potassium, and phosphorus.",0
"A leukemoid reaction is a complex and poorly understood response by the bone marrow to a variety of stresses; although any peripheral blood cell line may be involved, it is rarely a purely monocytic event.",0
Clinical and pharmacological aspects of accidental triamcinolone acetonide overdosage: a case study.,0
There were no other known risk factors for vascular disease.,0
OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.,1
"All cases presented within the first 10 postoperative days and improved with 1 month of cessation of cyclosporin (CyA), although halting, monotonous speech was evident to some degree in all five for up to 1 year.",0
"After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.",1
Drug-induced fever due to diltiazem.,1
Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.,1
"Two months later, at a follow-up visit, her serum cesium level was 1800 microg/dl, and her QTc interval was 494 msec.",0
"It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.",1
Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.,1
Protease inhibitor-induced carbamazepine toxicity.,1
In the mean-time the drug is available in Canada and England but not in the U.S.,0
"Nitric oxide, a potent smooth muscle relaxant, has been shown to be involved in the initiation and maintenance of erections; future research involving specific inhibitors of this chemical is indicated for the possible treatment of intraoperative penile erections.",0
"A single dose of dichloroacetate (DCA) was associated with a decrease in the serum lactate level by 20%, which persisted for more than 24 h.",0
"We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man.",1
CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.,1
Hypercoagulopathy induced by chemotherapy in a patient with lung cancer.,0
Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.,1
CONCLUSION: This case highlights the importance of timely application of aggressive measures even in patients with known diagnosis of a fatal malignancy as these interventions can prolong life and be of palliative benefit.,0
We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).,1
Myoclonic spasms following intrathecal morphine.,1
A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.,1
"While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.",1
We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.,1
"Thirty months after the start of chemotherapy, preleukemic changes were observed in peripheral blood and bone marrow, and acute nonlymphocytic leukaemia (M5 of the FAB classification) was diagnosed shortly afterwards.",0
We sought to assess the safety and feasibility of this approach.,0
Human immunodeficiency virus (HIV) protease inhibitors are associated with several metabolic abnormalities including hypercholesterolemia and hypertriglyceridemia.,0
We report 4 patients who developed symptoms of myasthenia gravis within 2 weeks of starting treatment with a statin drug.,1
"The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.",1
New therapeutic approaches should be explored.,0
"The technique of immunocytochemistry was used to identify myoglobin in kidney, confirming a diagnosis of neuroleptic malignant syndrome following an otherwise obscure autopsy in a decomposed body.",0
"There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.",1
"During the anti-tuberculous therapy, visual loss can be related to ethambutol toxicity or the tuberculosis infection itself.",1
"Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.",1
To our knowledge this is the third article presented in the literature so far.,0
Three case reports.,0
We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.,1
"METHODS: 33-year old man with bilateral nonrhegmatogenous retinal detachment, misdiagnosed as uveitis, iatrogenically treated with systemic corticosteroids.",0
Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.,1
"We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.",1
Vancomycin administration led to a good outcome for this patient.,0
The patients immune system and lung function slowly recovered during the same time period.,0
"Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.",1
Hepatic damage after danazol treatment.,1
"Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.",1
"We hypothesized that VVR induced inflammation and adversely affected mucociliary function, and tested this hypothesis in an animal model of airway inflammation.",0
"Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.",1
Pneumocystis carinii pneumonia due to corticosteroids.,0
The authors describe a case of the catatonia syndrome associated with disulfiram therapy.,1
That the drug was directly responsible for the observed complications is suggested by the clinical course and by in vitro lymphocyte transformation studies.,0
"Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.",1
A more likely cause of the inspiratory obstruction appeared to be forward bending of the neck combined with mouth-clenching spasms.,0
"Baseline examination and investigations were performed, including fundus fluorescein angiography, and the patients were given a single intravitreal injection of triamcinolone (4 mg/0.1 mL).",0
We describe three HIV-infected patients who were given MTX for severe psoriatic arthritis.,0
Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinicopathologic syndrome with characteristic features.,0
"Based on this report and previous case reports, caution is advised when concurrent warfarin and 5-fluorouracil are prescribed.",0
"Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with ""familial seizure disorders"" may in fact have the long QT interval syndrome.",1
"With current donor evaluation protocols, the risk of transmitting infections by exogenous contaminated grafts seems to be more frequent than true donor-transmitted infections.",0
"Although dipyridamole perfusion imaging has a good safety record, serious side-effects may rarely occur.",0
These disorders may be the basic clinical manifestation of cancer or may result from vigorous cancer treatment.,0
Pulmonary toxicity with mefloquine.,1
Clostridium difficile colitis associated with cisplatin-based chemotherapy in ovarian cancer patients.,1
We describe the first case of disseminated salmonellosis in a patient treated with temozolomide.,1
A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.,1
"OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.",1
Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.,1
"From these, three patients with myopathy were found for a total of 303 patient-years of therapy, for an incidence of 1 in 100 patient-years (95%, confidence interval 0.2-3).",0
Unusual pigmentary changes associated with 5-fluorouracil therapy.,1
The patient had a history of alcohol abuse; alcohol intake as well as withdrawal can also cause seizures.,0
Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.,1
"Data from the Cincinnati Transplant Tumor Registry indicate that of 662 patients treated for posttransplant lymphoma, 277 patients died of cancer and 137 died of other causes, of which infection was a major factor.",0
Further surveillance and caution are suggested in patients with known coronary artery disease or atrial dysrhythmia.,0
"DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.",1
We describe a patient who developed adrenal insufficiency (AI) after this protocol.,0
Various case reports concerning dapsone-induced agranulocytosis are reviewed.,1
"We describe the case of a 10-year-old girl with two epileptic seizures and subcontinuous spike-waves during sleep, who presented unusual side-effects related to clobazam (CLB) monotherapy.",0
"The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.",1
"Drug rash with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe adverse drug reaction affecting multiple organs caused by drug treatment.",0
"The cat was admitted with acute respiratory distress, vomiting, and collapse, which began 15 to 20 minutes after topical application of the drug.",0
"METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.",1
Herbal remedies generate more than 1.8 billion dollars in annual sales in the United States.,0
Dorzolamide-induced choroidal detachment in a surgically untreated eye.,1
"To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.",1
"However, 19 days after starting amiodarone, serum testing indicated a hypothyroid status that was not recognized clinically.",0
High-flux haemodialysis treatment as treatment for carbamazepine intoxication.,0
Gabapentin-induced mood changes with hypomanic features in adults.,1
Recurrent aortic valve prosthesis dehiscence secondary to aortoarteritis: three case reports and literature review.,0
The cases demonstrate that ECT has significant but short-lived antipsychotic effects when used alone.,0
Diagnosis was confirmed by histological and mycological examination.,0
Nevirapine is a non-nucleoside reverse transcriptase inhibitor used in the treatment of human immunodeficiency virus (HIV)-infected patients and in post-exposure prophylaxis.,0
"OBJECTIVE: The aim of this study was to evaluate the present status of surviving patients 10 years later, together with the latest clinical and histological data on patients who had died.",0
Upper gastrointestinal haemorrhage is a serious complication of aspirin and clopidogrel (dual) anti-platelet therapy with a high morbidity and mortality.,1
The authors intend to carry out a case-control study on patients treated with tamoxifen for breast carcinoma to reveal the possible presence of endometrial carcinoma.,1
"Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands, and most commonly seen in patients undergoing chemotherapy for treatment of a malignancy.",0
We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.,1
Rapid improvement in muscle strength accompanied by prompt resolution of abnormal elevation of muscle enzymes followed cessation of both medications.,0
Ultrasound-guided stellate ganglion block successfully prevented esophageal puncture.,0
"These were gradually lysed after two successive administrations of streptokinase (1.5 x 10(6) units over 24 h), and one session of recombinant tissue type plasminogen inhibitor (100 mg over 6 h).",0
"Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.",1
"Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.",1
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.,1
Engraftment occurred on day +35.,0
Inappropriate antidiuretic hormone secretion after high dose vinblastine.,1
"Therefore, parenteral amiodarone was implicated as the cause of acute hepatitis in this patient.",1
"We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.",1
"Theoretically, insulin-sensitizing thiazolidinediones (TZDs) should be beneficial in this patient population.",0
"DISCUSSION: Fifty percent of VPA is metabolized by glucuronidation, 40% undergoes mitochondrial beta-oxidation, and less than 10% is eliminated by the cytochrome P450 isoenzymes.",0
The following case demonstrates marked improvement in treatment-resistant RSD pain with intramuscular ketorolac.,0
An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase.,1
"To the best of our knowledge, this is the first report of an association between sunitinib and gynaecomastia.",0
A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.,1
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.,1
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.,1
CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.,1
Electrocardiographic findings and laboratory data indicated a diagnosis of acute myocardial infarction due to the L-thyroxine therapy.,1
RESULTS: Three patients with histories of impotence experienced a return of sexual potency after treatment with fluoxetine.,0
"Linezolid, the first approved oxazolidinone, appears to be a promising new agent for the treatment of serious Gram-positive infections.",0
Hypersensitivity to this agent appears to develop after frequent exposure such as with the once-weekly regimens often used to treat brain tumors in pediatric patients.,0
Leuconostoc bacteremia after liver transplantation: another cause of vancomycin resistant gram-positive infection.,0
"Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.",1
After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.,1
It is a cumulative dose-dependent phenomenon reported to occur most often after 2 weeks of therapy.,0
CONCLUSIONS: The piloerection observed after the replacement of fluvoxamine with milnacipran in this patient appears to have been due to an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine induced by milnacipran.,1
Choroidal hemorrhage associated with systemic tissue plasminogen activator.,1
"Amiodarone, a class III antiarrhythmic drug, is one of the most effective drugs used in the treatment of ventricular and paroxysmal supraventricular tachyarrhythmia.",0
A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.,1
No side effects were observed and improvement was sustained during a mean of 7 months (range 3-12 months) follow up.,0
The medical chart of the patient was reviewed.,0
"Common manifestations of toxicity, like confusion and ataxia, are well known.",0
"Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.",1
"PATIENTS: Two women, ages 49 and 34 years, with endometrial hyperplasia without squamous metaplasia who were treated with progestin.",0
CONCLUSIONS: Cicatrization in the substantia propria of the conjunctiva by excessive lymphocytic infiltration after topically administered antiglaucoma drugs including dipivefrin is a possible mechanism of action for entropion.,1
Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy.,1
Mental nerve neuropathy as a result of hepatitis B vaccination.,1
Nephrotoxicity of selective COX-2 inhibitors.,0
The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.,1
OBJECTIVE: To describe and discuss the use of continuous intravenous infusions of haloperidol to treat severe delirium and agitation in 3 intensive care unit (ICU) patients.,0
Hypersexuality with antiparkinsonian therapy.,0
"The next day similar symptoms developed with rechallenge of the same brand of sustained-release verapamil in a 120-mg formulation, and verapamil was discontinued.",0
"It is particularly important in the treatment of systemic lupus erythematosus (SLE) since it reduces new organ involvement and disease flares, and relieves skin and joint symptoms.",0
"However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin.",1
We report four cases of severe corneal ulceration in methamphetamine abusers.,1
Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.,1
Caution is therefore recommended in using ACE inhibitors to treat hypertension in patients with ADPKD who are at high risk because of compromised renal function and massive cystic involvement.,0
Routine ophthalmic observation for the development of optic neuropathy is strongly recommended for patients with significant risk factors that could increase the chance of side effects and those on longer treatment courses.,0
Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.,1
DESIGN: Case report.,0
Acute interstitial nephritis due to pantoprazole.,1
"METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.",1
"We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).",1
Mammary gigantism is a rare complication of D-penicillamine treatment.,1
"We report a case of calciphylaxis in a patient with normal renal function and hypoparathyroidism, who responded to treatment with sodium thiosulfate.",0
"Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.",1
No further problems were encountered over the follow-up period of nine months.,0
In 20 healthy volunteers we found no slow acetylator genotypes.,0
"A bubble in the inferior sagittal sinus was observed on the day of the stroke, which then disappeared within 24 hours.",0
The authors present two patients in whom it was necessary to substitute the Erwinia enzyme for the E. coli enzyme because of the occurrence of severe allergic reactions to the E. coli enzyme.,0
"Signs of severe liver disease included elevated aminotransferases, conjugated hyperbilirubinemia, significant coagulopathy, hepatosplenomegaly and ascites.",0
"METHODS: A retrospective review of patients originally diagnosed with ulcerative colitis, status post colectomy and IPAA, who developed findings compatible with Crohn's disease was undertaken.",0
Late lethal hepatitis B virus reactivation after rituximab treatment of low-grade cutaneous B-cell lymphoma.,1
We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.,1
Atomic absorption analysis showed no significant change in the aluminium content of bone with treatment.,0
"It is noteworthy that the superior sagittal sinus thrombosis occurred during a haematological recovery period, with rapid responses to treatment with 6-mercaptopurine and high doses of adrenocorticosteroids.",0
"Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.",1
Intravenous ribavirin was obtained and administered for 5 days without success; the patient's mental status deteriorated rapidly and she died on day 69 post-transplant.,0
"Since this amount of FAB was insufficient to bind all DGTX present in the serum, cardiac DGTX toxicity (total AV-block) persisted.",1
"We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.",1
"In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.",1
"Twenty-one days after starting antiretroviral treatment, he became increasingly manic.",0
Currently available research on the use of risperidone to manage agitation in patients with dementia is discussed.,0
We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.,1
Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.,1
"A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.",1
"In the case of SSTIs, alternative treatment of these infections should be considered, especially when the bacterial pathogen is unknown.",0
Most cardiac surgical patients have had previous exposure to heparin for diagnostic or therapeutic interventions and hence have an increased susceptibility to developing heparin-induced thrombocytopenia (HIT) postoperatively.,1
The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.,1
"At surgery, the diagnosis of focal nodular hyperplasia was established.",0
BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.,1
Pseudoporphyria induced by propionic acid derivatives.,0
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
We describe a detailed case of fulminant hepatitis induced by nevirapine (Viramune) and treated by liver transplantation.,1
"Pellagra should be suspected whenever tuberculous patients under treatment with isoniazid develop mental, neurological or gastrointestinal symptoms, even in the absence of typical pellagra dermatitis.",1
"However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.",1
"It can also be found in the United States, where illegal sales have been reported in California gift shops, markets, bakeries, and other retail establishments.",0
Visceral leishmaniasis and macrophagic activation syndrome in a patient with rheumatoid arthritis under treatment with adalimumab.,1
"Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported.",1
Nocardia exalbida brain abscess in a patient with follicular lymphoma.,0
"Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.",1
We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.,1
PURPOSE: To report a case with concentric retinal pigment epithelium (RPE) atrophy after a single photodynamic therapy (PDT).,0
"Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.",1
"A case is described, believed to be the first reported, of a newborn in whom severe hyperreninemic hypertension developed after pyeloplasty of a hydronephrotic kidney.",0
RESULTS: A clinical diagnosis of fixed drug eruption owing to use of the PDE5 inhibitor tadalafil (Cialis) was made.,1
We assume that rIFN-gamma induced the de novo development of SLE in our patient.,1
"Abrupt, accidental withdrawal of trihexyphenidyl triggered severe exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties, prompting emergency admission.",1
METHODS: An 8-year-old boy with osteomyelitis was referred due to visual disturbance.,0
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).,1
"In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.",1
Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.,1
The incidence of RS among children with juvenile rheumatoid arthritis is significantly greater than the incidence of RS among children who do not have juvenile rheumatoid arthritis.,0
"Physicians using this ""new"" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.",1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
Four weeks after the end of the chemotherapy she developed interstitial pneumonitis and irreversible lung fibrosis.,0
"After calling the salon and consulting Poisindex, the substance was found to be Mar-V-cide, containing 20% Hyamine 3500, 50% cationic detergents, 20% isopropyl alcohol, and 1% sodium nitrite, which caused the methemoglobinemia in this case.",0
We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.,1
Renal biopsy showed diffuse proliferative glomerulonephritis with cellular crescents.,0
The patient's score on the Naranjo adverse drug reaction probability scale indicated that the relationship between this adverse reaction and heparin was probable.,0
Corneal endothelial dysfunction associated with amantadine toxicity.,1
"We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.",1
Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.,1
Many augmentation strategies have been tried in the past with varying levels of success or safety.,0
Fulminant hepatitis associated with disulfiram.,1
Urethral syndrome patients have irritative bladder symptoms in the absence of any objective urological findings.,0
This unprecedented phenomenon may be due to antiretroviral therapy.,0
"Current therapy with oral baclofen and benzodiazepines is useful but has variable success, particularly in severe cases.",0
"Heparin was discontinued, and an argatroban infusion was initiated.",0
Theophylline intoxication following viloxazine induced decrease in clearance.,1
The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.,1
"Various treatment modalities, such as an epidural blood patch, use of glue, removal of catheter, and surgical closure of dura and subdural blood patch, have been reported previously.",0
"Three ovarian thecomas, which are considered to be estrogenic tumors, were associated with endometrial malignant mullerian mixed tumor, mullerian adenosarcoma, and low-grade stromal sarcoma in postmenopausal women.",0
Active vitamin B12 contains cobalt in its reduced form (Co+).,0
Colchicine has been reported to be a safe and effective medication in the treatment of early phase of Peyronie's disease (PD).,0
Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.,1
The patient was not obese.,0
TB should always be considered as a possible diagnosis when treating febrile immunocompromised patients.,0
"In addition, he was given a continuous infusion of 400 micrograms daily human recombinant granulocyte macrophage-colony stimulating factor (rh GM-CSF) for 17 days.",0
"In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.",1
"It was characterized by hyperandrogenism and polycystic ovaries in all cases, and it was associated with weight gain and menstrual disorders in 2 of the 3 women.",0
"Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon.",1
Other potential mechanisms for the drug interaction may also exist.,0
"On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.",1
DATA: A 16-year-old girl was treated with risperidone for mood lability and impulsivity at a community hospital.,0
An uncommon cause of delayed postpartum hemorrhage is a pseudoaneurysm of the uterine artery.,0
N. sicca should be considered as a possible pathogen in CPD-associated peritonitis.,0
"He ran out of medication, was unable to refill his prescription for 2 days and presented to the emergency department in status epilepticus.",0
"Despite the large number of cases with mediastinitis described in the literature, the chest closure with only an omental flap without closure of subcutaneous tissue and skin is rare.",0
We describe a patient in whom impressive hypoglycemia developed following treatment with this agent.,0
Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.,1
Osteonecrosis in a patient with Crohn's disease unrelated to corticosteroid use.,0
CONCLUSIONS: Serious lead poisoning continues to occur and there appears to be complacency regarding the hazard posed by lead paint in old houses.,0
Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.,1
"The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.",1
"In addition to reporting this case, we review the literature regarding enteroviral infections after transplantation.",0
Effect of clozapine in severe tardive dyskinesia: a case report.,0
"Transrectal ultrasonography of the prostate demonstrated an average decrease in prostatic volume of 58% at 6 months, with the greatest rate of decrease occurring during the 2nd to 5th months of treatment.",0
"Recently, UFT has been extensively studied for colorectal, pancreatic, and various types of cancer in North America and Europe, especially with leukovorin.",0
"Two days after the drug was discontinued, the duration of the QRS complex was normalized.",0
"Before onset of treatment, level of GABA in CSF was highly lowered (16 pmol/ml), pyridoxine level in serum was within normal range.",0
Use of lamotrigine to augment clozapine in patients with resistant schizophrenia and comorbid alcohol dependence: a potent anti-craving effect?,0
We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.,1
Six days after starting acyclovir she exhibited signs of lithium toxicity.,1
Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.,1
He stated he was fit and well and denied taking any medications.,0
Total white cell count and neutrophil count returned to normal and she made an uneventful recovery.,0
Methylphenidate (Ritalin)-associated cataract and glaucoma.,1
BACKGROUND: Etanercept is a tumor necrosis factor (TNF) inhibitor that has been licensed in the United States for the treatment of adult and juvenile rheumatoid arthritis as well as psoriatic arthritis.,0
"The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.",1
Minimal change disease in a patient receiving IFN-alpha therapy for chronic hepatitis C virus infection.,1
Intravenous administration of levodopa ameliorated a refractory akathisia case induced by interferon-alpha.,1
"Although the exact pathophysiological processes involved have not yet been established, the neurotransmitters dopamine, serotonin and gamma amino butyric aid (GABA) have been documented to play a significant role in the generation of hiccups.",0
"We remind clinicians that phenytoin toxicity can easily mimic a cerebellar lesion or alcohol intoxication, and suggest that in accordance with National Institute for Clinical Excellence (NICE) guidelines phenytoin should no longer be used as a first-line treatment for epilepsy.",0
"A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.",1
A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.,1
He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal.,1
A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.,1
"She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.",1
"Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.",1
"CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.",1
Plasma exchange should be done only in an intensive care setting and as a research procedure for children with JRA.,0
A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.,1
Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses.,1
"Flare of Kaposi's sarcoma (KS) is well described in immunosuppressed patients treated with corticosteroids and rituximab, but has not yet been reported during treatment with imatinib.",1
This was accepted as evidence for propranolol being the cause of this conduction disorder.,1
Ciprofloxacin-induced psychosis.,1
She presented the same symptoms after oral intake of metamizole.,0
Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.,1
The diagnosis was suspected in the setting of a negative anion gap and only later confirmed by direct measurement of the serum bromide level.,0
We conclude that there is insufficient evidence either to establish or eliminate a direct causal relationship between ACC and MMI use.,0
"Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.",1
"BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.",1
None of the patients demonstrated the requisite features of the 'Dilantin hypersensitivity syndrome'.,0
Actinomycin D associated hepatic veno-occlusive disease--a report of 2 cases.,1
The occurrence of additional signs and symptoms should alert the clinician to the presence of intracranial pathology.,0
No re-occurrence of pancreatitis was observed in a 16 month follow-up.,0
We describe the safety and efficacy of enfuvirtide therapy in 4 patients with severe hemophilia A.,0
"However, the patient continued to deteriorate and developed CMV pneumonitis.",0
L-asparaginase-provoked seizures as singular expression of central nervous toxicity.,1
There have been few reports on the imaging diagnosis and treatment of infection of interbody cages used in posterior lumbar interbody fusion.,0
Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases.,1
There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.,1
"Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.",1
Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6.,1
Toxic streptococcal syndrome.,0
Cerebrospinal fluid penetration and bacteriostatic activity of linezolid against Enterococcus faecalis in a child with a ventriculoperitoneal shunt infection.,0
Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection.,1
"Ultimately, this may possibly predispose a patient to increased dermatologic reactions, including TEN.",0
BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.,1
It is usually well tolerated and its application is simple.,0
This is the first time that the combination of PTX and vit-E has had a significant antifibrotic effect by completely reversing deep RIF as shown by CT scan normalization.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"These findings mean that the effect of the MP pulse therapy on renal function depends on the clinical state of the patient and that renal deterioration after the pulse therapy may be more marked in patients who are more nephrotic and more impaired in renal function and suggest that increasing sodium and water retention during an MP therapy and the associated renal interstitial edema, proposed as one of the mechanisms of acute renal failure occurring in patients with minimal-change nephrotic syndrome, may be responsible for the MP-induced transient renal failure.",1
In both patients seizures were associated with discontinuation of short-term agents with high antimuscarinic properties.,0
Rapid formation of Aspergillus mycetoma in a patient receiving corticosteroid treatment.,0
This case emphasizes the importance of proper work-up of patients with apparently progressive lymphomas.,0
The clinical course and results of renal biopsy studies suggest multiple causes of the renal lesions in this patient.,0
Central pontine myelinolysis (CPM) is removal of myelin material from neural elements in a way that is not clearly known as yet.,0
"ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.",1
"Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.",1
A possible case of carbamazepine induced pancreatitis.,1
"The patient was resuscitated, and subsequent serial cardiac enzymes indicated myocardial infarction.",0
"Successful treatment with dantrolene does not, however, preclude a recurrence of MH, and thus subsequent doses of dantrolene should be given.",0
"The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping.",1
The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.,1
Administration of pyridoxine to an infant after a long period of convulsions was followed by acute hypotonia.,1
"We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.",1
Management of hypertension and dyslipidaemia in patients presenting with hyperuricaemia: case histories.,0
Generalized lichen nitidus with involvement of the palms following interferon alpha treatment.,1
"In three cases acetohexamide (Dymelor), an oral hypoglycemic agent, was mistakenly given to patients instead of acetazolamide (Diamox), which had been prescribed for their glaucoma.",0
"Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.",1
"Renal insufficiency, however, persisted.",0
Paclitaxel is a chemotherapeutic agent with activity directed against several malignancies.,0
An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.,1
"We report three patients with transformed migraine, previously refractory to a wide variety of traditional preventive pharmacologic and nonpharmacologic interventions.",0
These cases underscore the importance of careful examination of the retinal periphery before management of any presumed optic neuropathy with steroids.,0
"This case highlights the potential danger of high dose vitamin supplements in children, and the salutary effects of treatment with bisphosphonate.",0
Rhabdomyolysis in patients with acute lymphoblastic leukemia.,0
One patient also manifested marked disinhibited and disruptive sexual behavior.,0
Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms.,1
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.,1
Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism.,1
Flucloxacillin-induced aplastic anaemia and liver failure.,1
"The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).",1
"The safety of and indications for combination therapy with methotrexate and etretinate are discussed, and the recent reports in the literature of experience with this combination regimen are considered.",0
"Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.",1
"We propose that patients being treated with curative intent receive full-dose intensity, using body surface area calculated on actual body weight or on ideal body weight with dose escalations if tolerated.",0
He had previously received both local tumor bed and craniospinal radiation therapy together with intensive myeloablative alkylator chemotherapy before autologous stem cell rescue.,0
"Although it is difficult to solely attribute intratumoral hemorrhage to aspirin, we have to be careful when prescribing aspirin for patients who have asymptomatic meningioma.",1
"We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.",1
Piloerection induced by replacing fluvoxamine with milnacipran.,1
"On the basis of these findings, a therapeutic approach to patients with drug-induced psychosis in PD is suggested.",0
We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.,1
Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.,1
"Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.",1
Aluminum intoxication developed in three infants with azotemia who were not undergoing dialysis and who had been treated with aluminum hydroxide from the first month of life.,0
This report aims to highlight the fact that single-pulse transcranial magnetic stimulation may provoke a seizure even in the absence of gross neurologic abnormality.,0
An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.,1
"An immediate cholestatic liver reaction was also provoked by drug rechallenge, with spontaneous amelioration of signs and symptoms after drug discontinuation.",0
The dose-limiting toxicity of KW-2149 is pulmonary toxicity.,1
This paper describes a possible side effect previously unreported--papilledema not associated with peripheral neuropathy.,0
The buried bumper syndrome is a rare and late complication of percutaneous endoscopic gastrostomy tube placement.,0
An understanding of the proposed pathophysiology of various types of delirium will allow appropriate clinical measures to be taken.,0
"A difference in chemical structure between these two drugs, particularly of a sulfur moiety, may help explain why the drug-induced disease did not recur.",0
This deterioration started 3 months post-treatment and worsened over the ensuing 4 years.,0
"Visual changes, headache, and elevated blood pressures were present on arrival to the emergency department.",0
He was well and his serum creatinine was 1.0 mg/dl at 22 years of age.,0
We report a case of a 23-year-old man who developed a vancomycin-induced anaphylactic reaction in the treatment of methicillin-resistant Staphylococcus aureus infection.,1
The patient died 7 years after the diagnosis of myeloma with extensive abdominal lymphoma.,0
This suggests the possibility that ACE inhibitors may uncover an asthmatic tendency in patients with pre-existing bronchial hyperreactivity.,0
"Despite vigorous therapy for the hyperthermia, he rapidly developed significant hypoxia requiring mechanical ventilation.",0
We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.,1
Various incidences of hemorrhagic complications have been cited in patients given anticoagulants after stroke or transient cerebral ischemia.,0
Therefore doses were adapted on the 3rd day of the course.,0
"To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.",1
Acute abdomen due to endometriosis in a premenopausal woman taking tamoxifen.,1
Methotrexate serum concentrations must be monitored because of the possible toxicity of drug elimination delay.,0
Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.,1
"While a number of psychotropic agents may induce SIADH, only a few reports of tricyclic-antidepressant-induced SIADH exist.",0
DISCUSSION: Half were treated with topical imiquimod.,0
OBJECTIVE: To present a previously unreported cause of neurologic compromise after cervical spine surgery.,0
Prolonged enteroviral infection in a patient who developed pericarditis and heart failure after bone marrow transplantation.,0
CONCLUSIONS: Caution should be exercised when using ciprofloxacin in the treatment of patients with personality abnormalities or symptoms of psychosis.,0
"DATA SOURCES: Case studies, abstracts, and research publications identified in MEDLINE and bibliographic review.",0
Two weeks following rechallenge with alendronate sodium resulted in recurrence of his scleritis.,1
Use of St.,0
"After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.",1
Development of hypertension in neuroblastoma during therapy: a case report.,0
"Traditionally, children with acute lymphoblastic leukemia receive prednisone, as part of multiagent remission-induction chemotherapy.",0
Antipsychotic medications have been associated with significant cardiovascular adverse effects and instances of sudden cardiac death.,0
"The highest intraoperative oxygen concentration was 33 percent, but 40 percent oxygen was administered for four days postoperatively.",0
The mechanism of RTA induced by FK506 has not yet been clearly elucidated.,1
New serologic tests show promise.,0
Ninety-nine of 171 (57.9%) patients were also prescribed prednisone.,0
Cholesterol microembolization and stable renal function with continued anticoagulation.,0
"Although, we cannot exclude the coincidence between the two diseases we discussed suspicious relationship between the interferon treatment and the tumour progression.",0
Leflunomide-associated weight loss in rheumatoid arthritis.,1
This treatment has the potential to cause severe vision loss as a result of intractable corticosteroid-induced glaucoma.,1
"While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.",1
"Urine volume ranged from 1,640 to 2,260 mL/24 hr, and serum creatinine level rose from 2.3 to 8.3 mg/dL.",0
We present a case report of a patient with typhoid fever who experienced a hypersensitivity reaction subsequent to the infusion of chloramphenicol sodium succinate.,1
RESULTS: Differences between the plaintiff's and defendant's experts' opinions are presented by utilizing the COAT literature.,0
We present and exemplify our routine test protocol for monitoring drug introduction and treatment regimen of cholinergic drugs in LEMS.,0
"Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.",1
Nitrendipine-induced gingival hyperplasia.,1
Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.,1
"While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.",1
It should be noted that such an infection can occur in patients treated with conventional chemotherapy against malignant lymphoma.,0
"Ten months after the injection, visual acuity remained at 20/50, and intraocular pressure measured 15 mm Hg without antiglaucomatous therapy taken.",0
"Nasopharyngeal carcinoma is a rare cancer in Western society, however there is a higher incidence in Asian.",0
Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.,1
"With the increasing use of chemotherapy for many different primary malignancies, secondary or therapy-related acute myeloid leukaemias (AML) and myelodysplastic syndromes (MDS) are becoming more common.",0
These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.,1
Putative drug-related pemphigus foliaceus in four dogs.,0
"The cessation of angiographic leakage on FA was achieved in all eyes (100%) after IVB, however the hypofluorescent line delineating the margin of the neovascular tissue appeared in ICGA seemingly according to the contraction of mCNV.",0
"During the final episode, open lung biopsy was performed and demonstrated typical changes of drug-induced pneumonitis, with interstitial infiltrates and fibrosis and proliferation of type II alveolar lining cells.",0
A 31 year old woman presented with a chest wall abscess due to Actinomyces israellii and Porphyromonas asaccharolytica (previously Bacteroides asaccharolyticus).,0
Does acyclovir increase serum lithium levels?,1
"Of the five patients, two had a marked response in total Hb in excess of 3 g/dl, two responded modestly with an increase in total Hb of 1-2 g/dl, and one did not respond.",0
Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.,1
Local ILP toxicity appeared with extensive edema and common peroneal neurologic impairment including paresis that remained severe 10 months later.,0
All eyes had conjunctival congestion and mild to severe corneal edema with Descemet's folds.,0
Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.,1
"In contrast to that in other nephropathies, the role of renin-angiotensin blockade in kidney transplantation is less well defined, and its anti-proteinuric effect is markedly reduced in the presence of segmental glomerulosclerosis.",0
"Blastoschizomyces capitatus (BC), a filamentous fungus of genus Trichosporum, is as an important opportunistic pathogen in the compromised host.",0
We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.,1
"Published 2001 Wiley-Liss, Inc.",0
We have safely used recombinant factor VIIa to treat bleeding in the immediate and long-term period following PCC-related MI.,1
"Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.",1
Acne provoked by gold seems not to have been described elsewhere.,1
"However, the use of lithium should be avoided with any patient who is purging, since it may exacerbate the loss of intracellular potassium, thereby increasing the risk of cardiac toxicity.",1
Restless legs syndrome due to interferon-alpha.,1
"In addition to improving insulin sensitivity, they generally result in a modest elevation of plasma HDL cholesterol.",0
PURPOSE: To report a case of bilateral anterior uveitis associated with ovulation induction therapy using clomiphene citrate.,1
Recurrent hyponatremia associated with citalopram and mirtazapine.,1
METHODS: We report a patient who had an anaphylactic reaction during the intravenous infusion of cyclosporine.,1
"Because of serious side effects of an increase in the QT interval causing torsades de pointes, dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting.",1
"Subsequent cardiac arrest and prolonged cardiogenic shock required aggressive pharmacologic support, intraaortic balloon pump insertion, and mechanical ventilation.",0
A few reports have appeared concerning switching from clozapine to other antipsychotics for treatment-refractory schizophrenia.,0
"Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurrent disease within a year.",0
Mucormycosis is a very rare opportunistic mycotic infection of diabetic children.,0
"BACKGROUND: Propafenone, a class IC antiarrhythmic, and citalopram, a selective serotonin reuptake inhibitor (SSRI), are widely used in older patients.",0
A diagnosis of aquagenic syringeal palmar keratoderma was made on the basis of these clinical and histopathologic findings.,0
Antibody therapy is capable of permanently abolishing the signs of symptoms of digitalis poisoning after a matter of hours.,0
"In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.",1
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.,1
This case is reported here for documentation because of its rarity.,0
"After developing two additional lesions that began to ulcerate despite treatment with imipenem, vancomycin, clindamycin, rifampin, and gentamicin, the patient consented to a skin biopsy.",0
"Augmentation, defined as a loss of circadian recurrence with progressively earlier daily onset and increase in the duration, intensity, and anatomy of symptoms, not compatible with the half-life of the drug, is associated with dopaminergic treatment in restless legs syndrome (RLS) patients.",0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.",1
It is frequently seen on the anterior aspect of the legs of women.,0
Capecitabine was discontinued and the allergic reactions resolved after the woman took diphenhydramine for 1 week.,1
Patch testing for ethylenediamine was positive.,0
Two patients with classical effort-induced angina pectoris associated with abnormal ST-segment depression on graded exercise testing and normal coronary arteriograms are described.,0
"In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy.",1
Torsade de pointes represents a potential complication of chronic amiodarone therapy.,1
"CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.",1
"Protocols that successfully incorporate platinum agents, despite a platinum hypersensitivity, are clinically relevant.",0
"Mental status, vital signs, and all laboratory parameters including thyroid function tests, normalized.",0
We therefore strongly argue in favor of extended screening recommendations for infectious diseases including viral infections before considering a therapy with infliximab.,0
"It is widely used in rheumatologic diseases, and has a very high efficacy/toxicity ratio.",0
"DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.",1
This report describes a case of bilateral ptosis induced by chloroquine.,1
"Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.",1
METHODS: Eight patients with cutaneous ulcerations from cryofibrinogenemia were treated with stanozolol.,0
"As a child, he had suffered a traumatic injury to his liver requiring the surgical repair of a laceration.",0
"As EGFR inhibitors are now incorporated with chemotherapy in advanced pancreatic cancers, clinicians should be aware of this potential complication.",0
"PTX (800 mg d-1) and vit-E (1000 U d-1), orally administered daily for 18 months, were well tolerated.",0
"We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.",1
"CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.",1
"Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.",1
"Although not typical, this result was suspicious of tumor seeding, the more since the lesions appeared in gray matter areas outside the high-dose-rate irradiation field.",0
CONCLUSION: There may be an association between raloxifene and the development of malignant mixed mesodermal tumor.,1
"She was found at delivery to have developed oligohydramnion, esophagitis, and a bleeding peptic ulcer.",0
Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.,1
The need for professional support for the carers of such patients should be recognized.,0
"At our institution, high-dose i.v. dexmedetomidine is used to provide sedation for pediatric patients undergoing nonpainful radiological imaging studies.",0
"We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome, a rare congenital disorder.",1
This is a case report of possible association of methylphenidate and enuresis in an 11-year-old boy with attention deficit hyperactivity disorder.,1
Photo-onycholysis may follow the use of various medications or may occasionally be idiopathic.,0
"Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.",1
"Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.",1
The patient's metastatic disease remained stable for the next 2 years.,0
"The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.",1
"However, its specific role in our patient remains uncertain.",0
"Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.",1
Such might not be the case with newer technologies.,0
"The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.",1
"BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.",1
"In both cases there was a progressive increase during treatment, in peripheral blood lymphocyte counts, skin reactions and in vitro cellular responses to PPD, and a sudden rise in ESR at the time of their deterioration.",0
"This case, although rare and atypical, should alert clinicians to consider the possibility of NMS as a complication of abrupt neuroleptic drug withdrawal.",0
"As termination was not an option for the family, the patient was extensively counseled and treated with oral ganciclovir.",0
"The definition of standard of care varies amongst jurisdictions, but is generally defined as either that care which a reasonably well-trained physician in that specialty would provide under similar circumstances or as what would constitute reasonable medical care under the circumstances presented.",0
"The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.",1
Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.,1
"In all three patients, HDL cholesterol levels returned to normal following drug withdrawal.",0
Trough whole blood tacrolimus concentrations ranged from 1.7 to 6.2 microg/L.,0
A literature review of the relationship between bulimia and affective disorder showed that the evidence from empirical research and case report studies suggests that a sizeable subgroup of bulimics suffer from bipolar disorder as well as bulimia and may benefit from antimanic medications such as lithium.,0
"A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.",1
"Three and a half years after cessation of any medical treatment he developed anemia, thrombocytopenia and a diagnosis of acute lymphocytic leukemia (ALL) was made.",0
"The first patient, a 9-year-old girl, had severe panuveitis complicated by traction retinal detachment, eventually requiring vitrectomy.",0
"However, there are few reports in the literature of ampicillin as a cause of acute interstitial nephritis.",1
"These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.",1
Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.,1
"Both infiltrates initially improved on topical antibiotic therapy, but over the next 18 days, 1 infiltrate worsened and repeat cultures were performed, which demonstrated A fumigatus.",0
"RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.",1
An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug.,1
"The platelet count was 221000/mm3, decreased 42% from the initial level, but remained within the normal range.",0
Review of all reported cases of the use of ATRA in pregnancy revealed no serious adverse outcomes or congenital anomalies although only very few cases had exposure in the first trimester.,0
The anterior chamber deposits still remain.,0
"These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.",1
"The radiographic and CT scan show the typical ""tram line"" intracranial calcifications.",0
"A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.",1
Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.,1
Report of a case.,0
Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.,1
Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.,1
OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.,1
We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).,1
"The proportions of lymphocyte subsets, as defined with monoclonal antibodies, and the proliferative response to mitogens were normal.",0
The biochemistry of paracetamol hepatotoxicity is outlined and the increased susceptibility of alcoholic patients to the hepatotoxic effects of paracetamol is remarked upon.,1
"The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.",1
Perioperative records were reviewed for use of topical 1:1000 epinephrine and for any intraoperative or postoperative complications related to its use.,0
"It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.",1
Systemic immunomodulatory agents have recently been approved for the treatment of rheumatoid arthritis and psoriasis.,0
"After the first year of transplantation, allograft coronary artery disease (ACAD) is the second main cause of death.",0
Disseminated Aspergillus terreus infection arising from cutaneous inoculation treated with caspofungin.,0
CONCLUSIONS: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy.,1
We recommend that fluorinated glucocorticosteroids should not be used on the face of infants and children.,0
Clinical diagnosis was made on the confirmation of soft palate movements synchronous with an audible clicking noise.,0
Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.,1
A 9.5-year-old girl after Fontan procedure for hypoplastic left heart syndrome had recurrent protein-losing enteropathy (PLE) develop 2 months after partial catheter closure of the Fontan fenestration.,0
Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.,1
The use of fresh frozen plasma and/or danazol before treatment prevents angioedema attacks.,0
Acceleration of ventricular response to atrial flutter after intravenous adenosine.,1
"Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.",1
"3. Thus, the decreased plasma cortisol level during alprazolam treatment of panic disorder was suggested to be caused not by symptom alleviation due to alprazolam but by alprazolam administration itself.",1
Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.,1
Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.,1
"The administration of ""sweet spirits of nitre"" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.",1
"We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.",1
"Based on these findings and since the patient had no signs of infection, his physician instructed him to discontinue the drug.",0
A successful vascular procedure was achieved with full heparinization without subsequent thrombocytopenia or thrombotic or hemorrhagic complications.,0
Recurrent bacteremia by Chryseobacterium indologenes in an oncology patient with a totally implanted intravascular device.,0
Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).,1
Neurotoxicity can occur at any time using high-dose cytosine therapy.,0
Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.,1
"Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.",1
"We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.",1
Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).,1
Posthypoglycemic hyperglycemia (rebound hyperglycemia) after overdosing of insulin was diagnosed in 6 cats with diabetes mellitus.,1
"A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.",1
"After two months of mechanical ventilation, the patient was stabilized.",0
A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.,1
A 42-year-old woman presented to our institution with a 2-week history of bone pain in the lower extremities.,0
"In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.",1
Infections are a major adverse effect during the treatment with anti-TNF-alpha.,1
"METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.",1
"METHODS: Switching of agents took place in two ways: converting only antipsychotic medications followed by other psychotropics, and changing all psychotropics simultaneously.",0
"Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.",1
Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.,1
The hyperglycemia once again resolved with discontinuation of the drug.,0
Severe vancomycin-induced anaphylactic reaction.,1
"In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.",1
"An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.",1
Priapism is a rare but serious adverse effect of psychotropic drugs where antipsychotic agents were implicated in 15 to 26% of priapism associated with medications.,0
Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine.,1
The patient had initiated treatment with oral pantoprazole 40 mg/d for gastroesophageal reflux 2 months prior to admission.,0
CASE SUMMARY: A 54-year-old white man received a heart transplant secondary to ischemic dilated cardiomyopathy.,0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
"The patient, a 28-year-old man suffering from panic disorder, developed several first-rank symptoms during fluvoxamine administration.",1
We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.,1
"Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).",1
"A drug lymphocyte stimulation test for salazoslufapyridine was positive, but the patch test was negative.",0
Sarcoidosis is a chronic granulomatous multisystemic disorder of unknown aetiology.,0