text,label
"We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.",1
"The evaluation, causes, and differential diagnosis of alopecia in a black woman are discussed.",0
The development of safer and more effective means for VT control is progressing and is needed.,0
"Blood, urine, and throat cultures were negative.",0
ECG and thallium-201 scintigram.,0
Lithium and maintenance ECT.,0
These results indicate that rEpo may benefit some patients with MDS and AA who are dependent on red cell transfusions while further studies will be necessary to elucidate the mechanism by which rEpo stimulates erythropoiesis and improves anemia in patients with these diseases.,0
Myasthenia-like syndrome induced by cardiovascular agents.,0
RESULTS: Scouting biopsies demonstrated multiple comedones and ruptured epidermoid cysts.,0
This toxic effect was attributed to lomustine and was not seen in patients treated with carmustine alone.,0
Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.,1
CONCLUSIONS: The results of this self-selected case series must be interpreted with caution.,0
"Pulmonary histopathology demonstrated a mononuclear interstitial infiltrate without evidence of malignant, infectious, granulomatous, or vascular causes.",0
"To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.",1
General aneurysmatosis due to cheese consumption: complications of an endocarditis caused by Lactococcus cremoris.,0
"This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.",1
"These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.",1
Posterior circulation hyperperfusion syndrome after bilateral vertebral artery intracranial stenting.,0
Use of the Naranjo probability scale showed the relationship of itraconazole therapy and the occurrence of acute hepatitis as probable.,0
"However, it is controversial whether progressive hepatic lesions develop in complete abstainers as a result of long-term cyanamide treatment.",0
It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.,1
Weight loss during therapy with olanzapine orally disintegrating tablets: two case reports.,0
"We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.",1
"Cholesterol microembolization as a sequela of oral anticoagulant therapy has been reported to cause infarction of virtually any organ, often resulting in death.",0
"The child, at present 15 months old, has had to undergo two operations for fronto-orbital advancement because of insufficient growth of the mid-face, nasal airway hypoplasia and increased intracranial pressure.",0
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).,1
Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.,1
"We examined the correlations between the individual changes in serum creatinine (Scr), body weight (BW) and urine volume (UV) before and after the pulse therapy and other laboratory data such as Scr, total serum protein and albumin.",0
METHODS/RESULTS: This paper presents a new case of rifabutin uveitis and a review of the various published reports to date.,1
Disseminated Nocardia asteroides and coinfection with Trichophyton rubrum in a renal transplant recipient.,0
A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.,1
"During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.",1
The authors report a world class runner who sustained a rupture requiring surgical intervention.,0
Calcium administration should also be considered.,0
Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype?,1
Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.,1
Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.,1
A case report.,0
"Although this can be coincidental, it can also suggest that the basis of a thrombus may dissolve first with any, including oral, anticoagulation.",0
Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity.,1
"To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.",1
"Classification included dry (7%), mild (48%), moderate (39%), and severe (6%).",0
A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months.,1
The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.,1
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.,1
"We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).",1
"However, the use of lithium should be avoided with any patient who is purging, since it may exacerbate the loss of intracellular potassium, thereby increasing the risk of cardiac toxicity.",1
A postmortem liver biopsy revealed adenocarcinoma undergoing necrosis.,0
We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.,1
"The likelihood of an acute respiratory reaction during treatment may therefore depend on the bacillary load, the extent of lung disease present, and its severity may be related to the pre-treatment immune status of the patient.",0
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.,1
CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.,1
"Diagnosis was assessed according to the international AIH scoring system, including liver biopsy and confirmed by positive response to steroid challenge.",0
The case illustrates the classic features of the syndrome and its dramatic response to corticosteroid treatment.,0
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
This case is the first report in which RLS augmentation is shown to be characterized by motor hyperkinesias paralleling levodopa plasma pharmacokinetic profile.,0
"Six received intra-arterial alteplase and 1 underwent intracranial angioplasty; in a final patient, technical aspects prevented intra-arterial therapy.",0
"Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.",1
"Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.",1
"However, engraftment was not achieved.",0
Surgery and anaesthesia were uneventful and she gained good symptomatic relief.,0
"Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.",1
We conclude that these agents should be used with great care in patients in whom atherosclerotic vascular disease is likely.,0
"We describe a patient with Wilson's disease who presented with neurologic disease, was treated with D-penicillamine, and suffered sudden neurologic deterioration coincident with therapy.",1
His recovery was uneventful.,0
Methylephedrine is generally harmless and is contained in many cough and cold preparations.,0
Sirolimus-associated pneumonitis has been described in renal transplant patients.,0
The novel antipsychotics offer great potential for improving compliance.,0
Oral ketamine: a promising treatment for restless legs syndrome.,0
There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.,1
"However, 3 months later he developed increased intraocular pressure and a recurrence of the cystoid macular edema.",0
"CONCLUSIONS: These findings suggest that, in patients who are susceptible, the periocular or systemic absorption of inhaled corticosteroids may be sufficient to produce CSC in humans, supporting previous hypotheses regarding the pathogenesis of the disorder.",0
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.,1
"Clonazepam was given as needed, and the patient was discharged on February 1 with myoclonus that soon subsided.",0
"CT showed deep RIF extending from the vocal cords to the carina, with laryngotracheal compression but without cancer recurrence.",0
"We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.",1
"We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.",1
"A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.",1
Hyponatraemia developed after rechallenge with controlled release carbamazepine.,1
This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.,1
"Adverse reactions, however, are relatively common as well.",0
Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.,1
Ramipril-induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before.,1
We report a patient who developed acute pancreatitis during amiodarone therapy.,1
Pemphigus vulgaris (PV) is a rare but potentially fatal autoimmune bullous disorder which frequently affects the oral mucosa.,0
The study was approved by the McGill University Health Centre Research Ethics Board.,0
Jaundice induced by streptokinase.,1
CONCLUSION: This is the first report of keratitis caused by Nocardia exalbida.,0
It has been described most recently in patients with solid tumors who receive taxane-based therapy.,0
Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome.,1
Gemcitabine therapy has been associated with radiation recall reactions when used in the treatment of carcinoma.,1
We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.,1
"His diarrhea, consisting of 10 to 12 loose stools a day, had continued for approximately two weeks and was accompanied with abdominal cramping, fever, anorexia, and weight loss.",0
Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.,1
"The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.",1
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).,1
We believe that the infection was due to asymptomatic ethmoid sinusitis.,0
"Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.",1
A typical regimen is cytarabine 3 g/m2 iv over one to three hours q 12h for a total of 8 to 12 doses.,0
"A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.",1
Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism.,0
"After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.",1
The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.,1
"PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.",1
CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.,1
"In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.",1
Recurrent septicemia with lethal outcome during and after cyclosporine therapy in severe ulcerative colitis.,1
Concomitant use of statins and cyclosporine should be avoided.,0
We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.,1
Enalapril-induced anemia in two kidney transplant recipients.,1
We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.,1
"Enoxaparin therapy was discontinued, and the patient was maintained on oral warfarin.",0
"Retinal abnormalities, including retinal hemorrhage and ""cotton-wool"" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.",1
Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.,1
The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.,1
"With careful sequential clinical and laboratory monitoring, even this type of cerebrospinal fluid shunt infection can be eradicated without catheter removal and replacement.",0
"Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.",1
Magnetic resonance imaging revealed regional kyphosis and large swollen paraspinal muscles impinging on the spinal cord without epidural hematoma.,0
Almost all of the suspected adverse drug reactions (ADR) from 1% lindane have involved substantial misuse.,0
The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.,1
Such anagen effluvium with lichenoid eruption following INH therapy has not been observed previously.,1
"The most common cutaneous adverse event is an acneiform eruption, which occurs in more than 50% of cases.",0
Her initial EEG showed a pattern of spindle coma with some responsivity of the background.,0
"Mecasermin [rDNA] (Increlex; Tercica, Inc.) is recombinant insulin-like growth factor-I (IGF-I) that has been approved to treat growth failure in children with severe primary IGF-I deficiency.",0
At this time most of the DGTX in serum was FAB-bound.,0
Little inflammatory change was noted in either the epithelial or stromal layers of the failed graft.,0
"In CAPD patients with candida peritonitis, fluconazole seems to offer several advantages over other antifungal drugs.",0
"When the trazodone was reduced, the involuntary movements promptly ceased.",1
a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.,1
Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.,1
The case cited here highlights the need for continued awareness education for physicians who may use ceftriaxone to treat common illnesses such as acute exudative tonsillitis and otitis media in children.,0
Mechanisms and triggering factors of hypoglycaemia induced by mefloquine and some other anti-malarial quinine analogues are discussed.,1
"We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.",1
We report a case of a 64-year-old man with secondary adrenocortical insufficiency who has been on a chronic transdermal fentanyl treatment because of sciatic pain syndrome.,1
METHODS: Endoscopic retrograde cholangiography was performed to define the proximal and distal extent of intraductal tumor.,0
She underwent emergent surgical valve replacement.,0
In one case the recognition of anterior vitreous face contact to the cornea was delayed by the severity of the corneal edema.,0
"In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.",1
"While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.",1
The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.,1
"Paralytic ileus in patients undergoing bortezomib treatment has been reported, although a definite attribution to bortezomib administration has not been established.",1
"This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.",1
"We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).",1
"Reversible posterior leukoencephalopathy syndrome (RPLS) is a syndrome manifested by headache, nausea, vomiting, seizures, cortical blindness, and visual disturbances.",0
"At explant, all four systems had clots adherent to the surface of the tubing and connectors on the pump outflow side of the circuit.",0
De novo inflammatory bowel disease after pediatric orthotopic liver transplant: a case report.,0
Teicoplanin-induced agranulocytosis that followed vancomycin-induced agranulocytosis suggests a possible cross-reactivity between the 2 drugs.,1
A 53-year-old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day.,1
Corticosteroid therapy was continued for 8 months since there was still improvement of pulmonary function studies.,0
Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).,1
"We present a patient with typical aquagenic pruritus who responded well to PUVA, and who has remained well controlled on infrequent maintenance.",0
Knowledge of the stage of dental development at the time of oncology treatment and the type of therapy allows the clinician to predict dental effects of the chemoradiation.,0
"The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously.",1
Tardive seizure and antibiotics: case reports and review of the literature.,0
Affected persons usually are on chronic steroid treatment and in the fifth to seventh decades of life.,0
Bromide intoxication secondary to pyridostigmine bromide therapy.,1
Eruptive epidermoid cysts resulting from treatment with imiquimod.,1
"Candida-induced denture stomatitis usually does not reflect any deep-seated, systemic abnormality, the dentures being the primary predisposing condition.",0
A Flexiflo Inverta percutaneous endoscopic gastrostomy tube was successfully inserted by pull technique.,0
"However, none were as severe as the first rash.",0
We present findings from three patients who experienced a psoriasiform eruption apparently due to the antiepileptic agents sodium valproate and carbamazepine.,1
RESULTS: Ten eyes in 6 patients with late-onset interface inflammation and increased intraocular pressure were identified.,0
This article describes the case of a 25-year-old man found dead at home who had been prescribed olanzapine for schizophrenia.,1
"Around 1990, psychologists and educators began to notice increasing use of methylphenidate by students.",0
Interaction between tacrolimus and nefazodone in a stable renal transplant recipient.,1
"DISCUSSION: Toxic epidermal necrolysis is an infrequent, yet often fatal, severe, systemic, cutaneous disease most often the result of an adverse drug reaction.",0
"These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related.",1
"We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.",1
"The two patients underwent several courses of pulse corticosteroid therapy, each course consisting of three days of methylprednisolone 1000 mg daily, resulting in visual recovery to some extent.",0
Ultrasound study revealed enlarged kidneys with increased echogenity and loss of corticomedullary differentiation.,0
"We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.",1
"Based on the clinical status of the patient, it was suspected that several conditions contributed to the abnormal hypersensitivity to warfarin.",1
It gives the radiological and CT scan findings and the important role played by them in the diagnosis of this syndrome.,0
"While approximately 70% of patients with schizophrenia and other psychotic disorders show a clear-cut reduction of symptoms in clinical trials, there is considerable variation in individual patient outcome, ranging from complete remission to absolute refractoriness.",0
"An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.",1
We report a case of successful surgical management of arterial thrombosis after percutaneous thrombin injection of a femoral artery pseudoaneurysm in a 69-year-old woman.,1
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
"Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.",1
Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.,1
We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.,1
"CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.",1
"We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.",1
"In clinical practice, serum level monitoring of anticonvulsant drugs is usually adequate.",0
"When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.",1
During hospitalization the patient developed hemolytic anemia (Coombs positive) and lung metastases.,0
"We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.",1
"It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.",1
Disseminated varicella infection is a potentially life-threatening complication of chronic high-dose corticosteroid (CS) or immunosuppressive therapy.,0
The patient was then dialyzed for presumed acyclovir toxicity.,0
"During the course of therapy, the patient showed rapid onset of oliguria, dizziness, edema, and a pre-shock state.",0
"The results of this pilot study demonstrate that fluoxetine safely and effectively suppresses cataplexy and reduces the need for other, less desirable, anticataplectic agents.",0
"However, an association of Ritalin with glaucoma has been reported.",1
"A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.",1
OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.,1
Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.,1
Previous studies showed that clevudine has potent and sustained antiviral activity without causing viral resistance.,0
Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.,1
"After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.",1
One patient on ouabain also developed cardiomyopathy.,1
"A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer who was treated with adjuvant tamoxifen.",1
"To optimize future management of this problem we studied 2 poorly recognized factors in the pathogenesis and prognosis of genitourinary malacoplakia in transplant recipients: 1) the probable role of azathioprine as the specific immunosuppressive agent responsible for the pathogenesis of malacoplakia, and 2) the importance of the localization of the disease and its impact on the ultimate prognosis.",0
"Eleven surviving patients were also studied by analysis of serum aminoterminal propeptide of type III procollagen (PIIINP), which is an indicator of fibrogenesis, which is especially suitable for follow-up of fibrotic liver disease.",0
"In cases with or without small perforations, the technique minimizes or decreases fluid flow so that the surgeon has a clearer view of these tissues and can perform more thorough and accurate stripping of deeper layers of tissue.",0
"However, we recently saw two patients with renal tuberculosis treated with ethambutol in whom visual loss from toxic optic neuropathies was severe and irreversible despite careful ophthalmological monitoring and prompt discontinuation of the agent at the first sign of impaired visual function.",1
"We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.",1
Acute chest pain is a common presentation in emergency.,0
Their attenuation density values were appreciably less than that of calcium and they enhanced slightly with contrast.,0
"On colonoscopy, inflammatory lesions highly compatible with CD were found endoscopically and histologically in all patients.",0
Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.,1
"Patients with large pelvic tumor loads are, according to existing classifications, at high risk to die and to develop drug resistance.",0
Another important concept behind some medical myths is the overreliance on case reports or authoritative text.,0
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
Lethargy in a newborn: lithium toxicity or lab error?,1
Single case study.,0
Confirmation of the suspected drugs that cause hypersensitivity reaction is sometimes difficult.,0
"Likewise, Chinese herbal drugs are considered to be effective and to have few side effects.",0
Amphotericin B-induced cutaneous leucocytoclastic vasculitis: case report.,1
Successful use of sodium ferric gluconate in sucrose in a patient with multiple drug allergies.,0
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
Caution should be taken when designing estrogen-related experiments involving Brown Norway rats and other potentially sensitive strains.,0
"We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.",1
"A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.",1
"A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.",1
"Shortly after chemotherapy and an injection of pegfilgrastim, the patient developed poorly defined, rapidly progressive erythema, edema, and pain in his right forearm.",1
Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.,1
Neuroleptic malignant syndrome (NMS) is a rare but potentially serious complication of neuroleptic drugs.,0
"The authors report the case of a 61-year-old man with CML treated with imatinib with a good response, and they switched to dasatinib after grade 4 hepatic toxicity.",0
BACKGROUND: Nocardia exalbida was first reported in 2006.,0
"Interference with the cortisol axis by the microtubule antagonist, CPH82.",1
Salmonella oslo.,0
The coexistence of acute myeloid leukemia (AML) and CLL in the same patient has been occasionally reported.,0
"RESULTS: In a 22-year-old Thai woman with Graves' disease, tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo developed after 3 years of therapy with PTU.",1
The use of sulfonylurea medications in the treatment of type 2 diabetes mellitus is common.,0
CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.,1
"The symptoms arose within 3-5 min after immersion in water, as a white sponge-like appearance, and resolved after a variable drying period.",0
Majocchi's granuloma is a condition with chronic erythematous and indurated plaques that is a result of the rupture of a dermatophyte-infected infundibulum as a result of trauma.,0
CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.,1
The DLK in this patient is delayed longer than typically reported in the literature.,0
Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.,1
The patient recovered completely following withdrawal of antacids and sucralfate and short-term treatment with phosphate.,0
The use of high potency topical steroids for the treatment of oral vesiculoerosive diseases seems to have been a contributing factor in two of these cases.,0
"METHODS: This is a retrospective, open-label study of 24 patients; 18 of whom were not responding to accepted medication for treatment of their TS and six of whom were receiving no medication.",0
A young patient experienced marked sinus tachycardia while smoking marijuana and receiving therapeutic doses of nortriptyline.,1
"The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.",1
The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.,1
Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation.,1
"Of the 10 patients with MDS, 6 were suffering from refractory anaemia with sideroblasts (RAS) and 4 from refractory anaemia with an excess of blasts.",0
A clinical and microbiologic response occurred when anticoagulation therapy with heparin was added to the treatment regimen.,0
"However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.",1
"Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.",1
He developed immune-mediated diabetes mellitus with low C-peptide and positive antiglutamic acid decarboxylase antibody after completion of therapy.,0
It is unknown whether the vitamin K content or malabsorption of warfarin is the mechanism of resistance.,0
"A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.",1
"CONCLUSION: The recognition of this atypical presentation with a combination of opthalmoscopic, angiographic and OCT findings may avoid inappropriate diagnosis and treatment with corticosteroids.",0
To date little has been reported about the risk of therapy-related leukaemia (t-AML) in children receiving oral etoposide therapy.,0
Diagnosis requires CT scan and direct aspiration and culture of the liver abscess.,0
The patient responded to aluminum chloride applied topically.,0
He had a history of subtotal gastrectomy.,0
I suggest that prior to giving amphotericin B to patients with resistant kala-azar their electrolyte imbalance should be corrected.,0
"Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.",1
The patients were followed up for an average of 32 months (range 16-75 months).,0
"Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.",1
A follow-up cerebral angiogram demonstrated a small AVM arising off a branch of the pericallosal artery and a small arteriovenous fistula arising off the costal marginal branch.,0
Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.,1
This case demonstrates that severe anterior uveitis may develop after LASIK and needs prompt and vigorous management for resolution.,0
Symptoms resolved spontaneously and completely after 48 h.,0
Steroid hormone deprivation potentially contributed to neovascularization and bowel involvement.,0
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
Interferon-alpha affects the immune response in post-transplant lymphoproliferative disorder.,0
Visual hallucinations associated with zonisamide.,1
The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).,1
"Treatment with local antibiotics was initiated but the condition of the eye worsened, ultimately resulting in corneal perforation.",0
"A female patient with HER2 positive, metastatic breast cancer presented with pulmonary infiltrates, and a plural effusion dyspnoea after several months of trastuzumab treatment.",1
"The former had a slowly progressive course, did not respond to amphotericin B (AB), and died; the latter improved after a prolonged course of liposomal-AB.",0
"A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",1
We are unaware of previous reports of P. avidum hip arthritis.,0
We ultimately speculated that corticosteroid withdrawal induced the depressive symptoms in this case.,0
"We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.",1
Intravenous thrombolytic therapy has become standard treatment for acute myocardial infarction (AMI).,0
Treatment was stopped after 2 weeks.,0
We report three cases of ophthalmic problems that were treated with a short course of oral corticosteroids and which resulted in the development of hyperosmolar hyperglycemic nonketotic coma.,0
A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.,1
Quinine is universally used for the very common symptom of night leg cramps.,0
"We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.",1
This case is reported in support of the dopamine hypothesis for the etiology of schizophrenia.,0
"CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.",1
Further exacerbations of the rheumatic condition may be induced by treatment of the cancer.,0
"If suspected, prompt medical assessment should be arranged, including serum glucose and cortisol measurement.",0
"On the 4th day after the infusion, VWF antigen and VWF ristocetin cofactor increased to 40 and 78% of the control, respectively, and dental extractions were performed successfully.",0
The authors report the first case of bucillamine-induced giant mammary hyperplasia.,1
Treatment of periocular capillary hemangioma with topical clobetasol propionate.,0
"On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.",1
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
These idiosyncratic reactions may be transient and do not always necessitate drug discontinuation.,0
"A 40-year-old man with advanced HIV infection and Mycobacterium avium complex infection experienced rapid cognitive decline after commencement of ethambutol, and symptoms fully resolved with cessation.",1
The remaining clinical scenarios included intravenous catheter sepsis and factitious disorders.,0
Carbamazepine-induced systemic lupus erythematosus.,1
"The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.",1
No cardiovascular disorder with the exception of minor ischemic changes in ECG was revealed before treatment.,0
"A 24-year-old woman with ALL developed severe epigastric pain 168 days after CBSCT, followed by blistering eruptions 2 days later.",0
"Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.",1
Physicians should be cognizant of this potential complication in patients receiving thalidomide or thalidomide-like drugs who present with fever and pulmonary infiltrates and fail to improve despite treatment with broad-spectrum antibiotics.,1
Post mortem examination showed the cause of death to be intestinal infarction resulting from superior mesenteric and portal vein thrombosis.,0
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
A patient with a large hydatid cyst of the left lobe of the liver developed metabolic acidosis following rather liberal use of cetrimide-chlorhexidine solution as a scolicidal agent.,1
"The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.",1
An asymptomatic HIV-infected woman experienced right-sided renal colicky pain during treatment with indinavir.,1
STUDY DESIGN: Case report of Baclofen pump catheter failure investigated by radioisotope injection.,0
A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel.,1
The ROTEM analysis strongly suggested the presence of either a heparin effect or severe deficiency of coagulation factors.,0
"Dalteparin, an LMWH, was started at a maximum dose of 18,000 units subcutaneously once daily, according to British national prescribing guidelines.",0
Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity.,1
DISCUSSION: Angiotensin-converting enzyme (ACE) inhibitors are associated with a relatively high incidence of angioedema.,0
Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.,1
"She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.",1
These symptoms abated 1 week after fluvoxamine treatment was discontinued and haloperidol was started.,0
A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.,1
Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions.,1
"The first patient developed a monoarthritis 2 weeks after initiation of IFN-beta, which persisted during the 14 months of therapy and resolved with discontinuation of the medication.",1
Quinine induced coagulopathy--a near fatal experience.,1
Endophthalmitis due to exposure of anterior chamber intraocular lens haptic tip.,0
PURPOSE: The aim of this study was to discuss the potential implications of prolonged and aggressive treatment of long-term survivors of ovarian cancer.,0
Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.,1
The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent.,1
"The role played by repeated drug prescriptions from general practitioners without appropriate clinical and laboratory controls, and that of our patient's depression are discussed.",0
We describe a 14-year-old bone marrow transplant recipient who was anti-HBs-positive before the procedure and afterwards developed acute infection with hepatitis B virus (HBV).,0
This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder.,1
A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.,1
A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.,1
Antifungal therapy was given but her condition deteriorated and she died.,0
We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.,1
We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.,1
"METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.",1
"After the correction of hyponatremia, due to the high liver enzyme levels, he was diagnosed as rhabdomyolysis.",0
A complication of transesophageal atrial pacing in an infant with Wolff-Parkinson-White syndrome (WPW) is reported.,0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
These results indicate that lithium may cause biochemical hyperparathyroidism.,1
"Histologically, the heart presented diffuse eosinophilic infiltrates located around perivascular structures and focal myocyte necrosis with numerous interstitial eosinophils admixed with histiocytes.",0
He is in remission of AML and tuberculosis.,0
Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.,1
Published data on the use of vitamin D for prophylaxis or treatment of any form of osteoporosis fail to document benefits superior to those of calcium alone or calcium with estrogens and fluoride.,0
We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.,1
RESULTS: Six preterm and 2 term patients were included in the study.,0
Operative mortality was 64% in the prosthetic mitral thrombosis and 20% in the aortic one.,0
"Despite several doses of intravenous rasburicase (2 doses of 0.1 mg/kg and 4 doses of 0.2 mg/kg), as well as aggressive supportive therapy, the infant died of complications arising from uncontrolled TLS.",0
This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm.,1
Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose.,1
"SUMMARY: A 65-year-old Caucasian man was admitted to the hospital on January 26, 2006, for worsening congestive heart failure (CHF).",0
Post-radiation sarcomas following treatment of central nervous system malignancies is discussed.,0
OBJECTIVE: To report a case of significant hepatic and renal failure with the use of argatroban in a patient with heparin-induced thrombocytopenia (HIT) requiring continuous veno-veno hemodialysis (CVVHD).,1
"CONCLUSION: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the ""indirect"" pathway; (ii) the pathophysiological mechanisms of subthalamotomy induced dyskinesias may differ from those involved in L-dopa induced dyskinesias; (iii) dyskinesias induced by STN surgery resolve spontaneously as compensatory mechanisms develop.",1
It generally results in painless bleeding or abdominal pain.,0
"Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.",1
The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.,1
Lymphoma usually responds well to multiagent chemotherapy.,0
It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity.,1
"Few reports have described dermatologic adverse effects such as rash and pruritus, and, to our knowledge, none have discussed the seriousness or extensiveness of the rash.",0
"Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies.",1
We suggest that the treatment of hypoglycaemia with 50% solution of dextrose is associated with a significant risk factor in those diabetic individuals who are either allergic or are receiving beta-adrenoreceptor blocking drugs.,0
"The second patient, a 39-year-old man, showed endophthalmitis of the right eye.",0
Urethral syndrome: response to alpha-adrenergic blocking agents.,0
"This article reviews current human and veterinary literature regarding the microbiology, pathogenesis, and treatment of nocardiosis and reports on the successful treatment of systemic nocardiosis in two dogs.",0
We describe a patient with acute disseminated encephalomyelitis (ADEM) who was treated with high-dose intravenous methylprednisolone 2 days after onset of neurologic symptoms.,0
The diagnosis was made on the basis of inflammatory changes in the cerebral spinal fluid and localization of the abscess by means of computer and magnetic resonance tomography.,0
"Throughout approximately 3 years of treatment with these erythropoietin analogs, the patient's total daily dose of insulin was reduced in response to his decreasing A1C values, despite elevated blood glucose levels and the absence of patient-reported hypoglycemic events.",0
No other common disease known to affect mitral valves nor intake of other drugs (ergot derivatives or appetite suppressant drugs) was found.,0
Therapeutic effect of intradermal injections with difucosyl lactosamine (dimeric Lex) on patients with rheumatoid arthritis.,0
"Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole.",1
The patient was discharged five days after admission and referred to a hematology clinic for follow-up.,0
"We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.",1
Immunosuppressive measles encephalitis.,0
Fatal acute neurotoxicity is rarely encountered.,0
DESIGN: Case report.,0
"To our knowledge, these movements have not been reported previously as an adverse effect of quetiapine.",0
"Brompheniramine and dextromethorphan were 0.40 mg/L and 0.50 mg/L, respectively, in the blood sample and 0.16 mg/kg and 0.57 mg/kg in the liver sample.",0
Systemic lupus erythematosus and acute pancreatitis: a case series.,0
"A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.",1
Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.,1
The cost of the demanding lifestyle of military aircrew members and the fear of hypoglycemic episodes can result in periods of sub-optimal glucose control.,0
Turner's syndrome and its treatment are discussed.,0
"Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.",1
"The authors report a case of a Hickman catheter perforating the wall of the superior vena cava into the pericardium, resulting in accidental intrapericardial infusion of 5-fluorouracil (5-FU).",0
"It can occur in association with altered immunological conditions and the administration of various drugs, including corticosteroids.",0
Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine.,1
Three of the 36 patients were receiving aspirin for the treatment of juvenile rheumatoid arthritis.,0
"Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.",1
The patient's other comorbidities and medications have not been suggested as possible interactions with sertraline that can cause rhabdomyolysis.,1
"At the time of this writing (2 y), the patient has had no symptoms and has continued on the chemotherapy protocol as planned.",0
Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.,1
"We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.",1
This had been given systemically during the patient's last week of life.,0
"Also, concomitant therapy with antianxiety medications that may mask the symptoms of electrolyte disorders should be undertaken with caution.",0
"Vincristine (VCR) is commonly included in combinational chemotherapy regimens because of its synergy with a variety of other active agents, as well as its sparing of the hematopoietic system.",0
Flavimonas oryzihabitans (CDC group Ve-2) bacteraemia associated with Hickman catheters.,0
"Although adverse effects are usually mild, the author reports here a case of leucocytopenia and thrombocytopenia with quetiapine treatment that required its discontinuation.",1
Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.,1
"Although his renal function recovered completely with high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2, we present this case to emphasize that signs of renal toxicity may be present as early as 2 hours after the completion of a 4-hour MTX infusion, and to suggest that monitoring for MTX toxicity should perhaps begin within a few hours after the completion of 4-hour MTX infusion.",1
"The cerebral venous sinus thrombosis, involving cerebral veins, superior sagittal sinus and straight sinus, was diagnosed by cerebral angiography.",0
CONCLUSIONS: Terbutaline therapy did not appear to be associated with any significant adverse effects and warrants further application and study in this setting.,0
"When patients with PNH are infected by PVB19, they may show severe neutropenia and mild thrombocytopenia in addition to severe reticulocytopenia.",0
"DISCUSSION: Although there are several reports on extensive passage of lamotrigine into breast milk, this is the first published report of a serious adverse reaction in a breast-fed infant.",0
Effects of pergolide on nocturia in Parkinson's disease: three female cases selected from over 400 patients.,0
Probabilistic analysis of decision trees using symbolic algebra.,0
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
"We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.",1
"However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.",1
We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler.,1
Rheumatoid arthritis after 9 years of human immunodeficiency virus infection: possible contribution of tritherapy.,0
His symptoms resolved within 10 minutes.,0
Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.,1
"A ten year old boy who died of the consequences of an infrequent gastrointestinal complication, whilst on induction chemotherapy for acute lymphatic leukemia, is being reported.",0
We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.,1
"Intra-operatively, he suffered inadvertent injury to an intercostal arterial branch during isolation of the aorta below the graft.",0
"The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease.",1
"This property is similar to that of other lipophilic agents such as amiodarone, chloroquine, chlorpromazine, quinacrine, and suramin.",0
"Although inhibition of the angiotensin-converting enzyme is considered to be efficient treatment for hypertension associated with chronic renal failure, care should be taken when captopril is administered initially to a patient with decreased renal function, under the conditions of sodium and water depletion.",0
"This profile should trigger a ""red flag"" as to the possibility of phenobarbital behavioral side effects or exacerbation of preexisting maladaptive behaviors.",1
MATERIALS AND METHODS: A phase II study.,0
The use of rituximab has been uncommonly associated with delayed pulmonary toxicity.,1
"Therefore, ocular examination at baseline and every 6 months is indicated for patients receiving a regimen of amiodarone and/or digoxin therapy.",0
Timely diagnosis and management is crucial to maintain good structural and visual outcomes.,0
We describe the clinical course of 2 patients with Crohn's disease (CD) in whom lymphoma was diagnosed after treatment with infliximab.,1
"Thus, the eosinophilia myalgia syndrome can be associated with parenteral tryptophan administration.",1
"A 42 year old man, treated for testicular carcinoma with combination chemotherapy that included bleomycin, developed life threatening interstitial pneumonitis.",1
"During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.",1
This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.,1
"Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.",1
"With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.",1
"Long-term, controlled studies are required to specifically address this issue.",0
"A few recent individual case reports have suggested that a myasthenic syndrome may be associated with statin treatment, but this association is not well described.",1
"Her plasma cesium level was 2400 microg/dl (normal < 1 microg/dl), and her family was told to stop her alternative treatment regimen.",0
"Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.",1
OBJECTIVES: A delayed stroke-like leukoencephalopathy has been observed in patients receiving methotrexate (MTX) for childhood leukemia.,1
Several therapeutic and dietary manipulations failed to control these symptoms in previous reports as well as in an infant we have followed after Nissen fundoplication.,0
"A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.",1
"Intermittent, continuous outpatient dobutamine infusion in the management of congestive heart failure.",0
The long-term effect on corneal endothelium has to be studied further.,0
An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.,1
"Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.",1
PURPOSE: To report that acute lamotrigine poisoning may result in severe encephalopathy.,1
With this therapy left ventricular function improved and CHF resolved in each.,0
Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.,1
This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.,1
Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.,1
Thyrotropin-producing pituitary adenoma associated with Graves' disease.,0
"Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.",1
"The patient was treated with full mouth gingivectomy and 2-week recall visits for a period of 2 months consisting of oral physiotherapy instructions, scaling, and topical fluoride application.",0
CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum.,1
"DISCUSSION: The clinical presentation of ELP is nonspecific and ranges from the totally asymptomatic patient with incidental radiologic finding, like our patient, to the patient with acute or chronic symptoms attributable to pneumonia, pulmonary fibrosis, or cor pulmonale.",0
"When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.",1
Gangrene of the fingertips after bleomycin and methotrexate.,1
"When phenytoin was discontinued, valproate levels increased, and he progressively improved.",0
"The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).",1
We present a patient who developed extensive Molluscum Contagiosum (MC) lesions shortly after being started on HAART.,0
"N. asteroides sepsis subsequently developed, leading to his death.",0
Treatment consists of discontinuation of the offending drug and often high dose corticosteroids.,0
"We review the existing literature on this rare clinical entity, all-trans retinoic acid-induced myositis.",0
The pharmacist counseled the patient on the potential hazards of using herbal products with prescription medications.,0
We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy.,1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.",1
Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.,1
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.,1
"CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.",1
BACKGROUND: Diverse complications have been reported in association with the growth and medical treatment of uterine leiomyomata.,0
"Although the enuresis ceased, she developed throbbing headaches, nausea, vomiting, paresthesia, lethargy, fatigue, and altered mental status over the next 7 days.",0
Captopril-related (and -induced?) asthma.,1
"In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.",1
A case of severe visual loss following a single dose of vincristine is described.,1
The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.,1
Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.,1
"Thus, our report suggests that SKT could be a first-line agent for the conservative treatment of TOS.",0
"We present in this article the clinical features and autopsy findings of a steroid-dependent subject with asthma who died of acute, disseminated varicella.",0
Methemoglobinemia: an occupational hazard of phenylpropanolamine production.,1
"Although these eight patients had shown various mental, neurological and gastrointestinal symptoms, as well as skin lesions, the diagnosis of pellagra had not been made clinically.",0
"The study population included the affected patient (proband), nine of her blood relatives, and seven healthy volunteers.",0
The plasma concentrations of the active metabolite M6G were more than 10 times those normally seen and the half-lives of M6G and morphine were prolonged.,0
Chronic cystoid macular edema that does not respond to topical nonsteroidal antiinflammatory drops may resolve with intravitreal triamcinolone but not with bevacizumab.,0
"Although the transthoracic echocardiography did not reveal an intra-atrial thrombus, cardioembolism due to disintegration of a pre-existing thrombus was thought to be the underlying mechanism because the patient had atrial fibrillation.",0
A 68-year-old woman with parkinsonism showed cortical myoclonus and seizures under antiparkinsonian medication.,0
"By day 8 the patient was comatose, with minimal signs of brain activity and little hope for recovery; on day 12 he died.",0
"No hemodynamic instability or cardiac or renal sequelae were associated with the large, inadvertent bolus in our patient.",0
"We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy.",1
When folinic acid was ceased on the day of methotrexate in these patients their psoriasis improved.,0
Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.,1
"On postoperative day 30, the patient developed primary CMV disease that responded to ganciclovir.",0
Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.,1
"We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.",1
Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978.,1
The case of a 19-year-old woman with insulin-dependent diabetes and regular and NPH insulin hypersensitivity is presented.,0
Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.,1
"Familial, dexamethasone-suppressible, normokalemic hyperaldosteronism.",0
We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.,1
We describe a patient in whom this was the primary manifestation of drug hypersensitivity.,0
One of these patients relapsed after he stopped taking the preparation at his own initiative after 10 weeks.,0
CONCLUSIONS: The use of IL-2 in bedridden patients with performance status >2 must be given on an individualized basis.,0
A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.,1
"Phenytoin, verapamil, and acetazolamide were ineffective, but tocainide yielded good results.",0
"Indeed, the reported annual number of imported malaria cases increased to not less than 100.",0
rEpo was administered by i.v. injection three times a week for at least four weeks.,0
"Exposures to 4-hydroxycyclophosphamide, the combination of thiotepa/tepa and carboplatin were 94%, 117% and 71% higher than the median respective exposures in a non-obese population of patients ( n=24) receiving similar doses.",0
"When patch test are performed with several drugs of the same family, results seem to indicate an absence of cross-sensitivity, but in several patients, oral provocation test were needed because patch test gave no conclusive information.",0
We describe the first documented case of azathioprine-induced severe myelosuppression due to thiopurine methyltransferase deficiency in autoimmune liver disease.,1
Mycophenolate mofetil-induced neutropenia in liver transplantation.,1
Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.,1
The patient developed unusually severe hematological toxicity to chemotherapy as compared to nonsmall cell lung cancer patients without the GD defect.,0
Only one report links phenylpropanolamine consumption to an intracerebral hemorrhage in a patient with an AVM.,1
"ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.",1
We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.,1
"However, cyclosporine dependency is associated with the risk of nephrotoxicity.",1
INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.,1
"An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.",1
Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.,1
Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.,1
"The patient was discharged with a diagnosis of HCV-related active chronic hepatitis, skin porphyria, and type 2 diabetes.",0
Postmortem examination revealed only minimal neoplastic infiltration of the meninges.,0
"The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.",1
"The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.",1
Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.,1
Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.,1
With either discontinuation or decreased dosage of the drug the symptoms disappeared and did not recur.,0
Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.,1
"Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.",1
He had been receiving L-thyroxine therapy following mitral valve surgery.,0
"Two months later, hyponatremia was diagnosed, most likely syndrome of inappropriate antidiuretic hormone secretion.",0
"The majority of the induced lesions is in the distal ileum, sigmoid colon, or rectum.",0
OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.,1
We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.,1
Two cases of malignant hyperthermia (MH) are presented.,0
Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.,1
Three patients were treated with aminocaproic acid for medically uncontrolled hyphemas that developed after cataract extractions.,0
OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.,1
"Moreover, in the appropriate clinical setting, even in the absence of pulmonary signs or symptoms, diffuse pulmonary uptake of labeled leukocytes should alert the physician to the possibility of drug-induced pneumonitis.",0
Posttransplant lymphoproliferative disorder of the nasopharynx.,0
"We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.",1
The eighth exhibited concentric constriction.,0
Pathology evaluation of a specimen revealed a high-grade osteoblastic osteosarcoma.,0
The cancer developed on a very thin endometrium and transvaginal ultrasonography failed to detect it.,0
A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.,1
Ulcer became worse after tobramycin and gentamycin treatment for 2 days.,1
Removal of a well-fixed metal-metal hip resurfacing acetabular component.,0
"MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction.",0
Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.,1
The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.,1
Multiple keratoacanthomas after megavoltage radiation therapy.,0
A patient with ocular syphilis is presented.,0
"Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.",1
Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.,1
One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.,1
The mortality rate has been estimated at about 10%.,0
BACKGROUND: Fluticasone propionate was introduced in 1993 in the UK as a potentially safer inhaled corticosteroid than those already in use.,0
There is yet no explanation for the occurrence of hallucinations or psychosis.,0
"Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.",1
"An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.",1
More than 50 cases of tuberculous peritonitis complicating CAPD that have been reported in the English-language literature since the initial case was reported in 1980 are reviewed.,0
OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.,1
"Primary Central Nervous System Lymphoma (PCNSL) was seen in 2% of the liver, and 2% of the heart recipients.",0
Warfarin-associated thoracic aortic dissection in an elderly woman.,1
Ventricular fibrillation during transesophageal atrial pacing in an infant with Wolff-Parkinson-White syndrome.,0
Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.,1
We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.,1
RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.,1
"A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.",1
We report a case of a recurrent Listeria monocytogenes bacteraemia in a 46 year-old liver transplant patient.,0
"Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.",1
The nephrotic syndrome was treated successfully with prednisolone.,0
Acute psychosis associated with levetiracetam.,1
This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.,1
"Electron microscopy showed diffuse effacement of the glomerular epithelial foot processes, leading to a diagnosis of minimal change nephrotic syndrome with interstitial nephritis.",0
Flurbiprofen-associated acute tubulointerstitial nephritis.,1
We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.,1
Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.,1
We report a case with chronic hepatitis C (CHC) who developed sarcoidosis after the treatment by interferon alpha and ribavirin.,1
"In the same period, healthcare professionals submitted 10 635 reports, concerning 16 722 ADRs.",0
"Serial hemograms were characterized by persistent thrombocytosis (platelet count, 577,000 to 1,200,000/microl) with abnormal platelet morphology.",0
Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.,1
Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.,1
The neonate weighed 884 g and died 1 h after birth.,0
We postulate that the patient's hearing loss was the result of ketoralac's direct and indirect ototoxic effects that were potentiated as a result of her underlying illness and medications.,0
"After 6 weeks of oral Sildenafil treatment, her serum albumin and the fecal alpha-1-antitrypsin levels normalized, and her exercise tolerance had increased.",0
DISCUSSION: Both cases met Stembach's criteria for serotonin syndrome and had serious extrapyramidal movement disorders.,0
"When the skin lesions had improved, phlebitis was found at the injection site of the peripheral vein catheter.",0
"In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.",1
PURPOSE: Platinum-based therapy is the cornerstone of ovarian cancer treatment.,0
We report a cytomegalovirus (CMV) IgG +ve 56-year-old patient who underwent autologous rescue with CD34(+) selected peripheral blood stem cells as part of consolidation therapy for multiple myeloma and subsequently developed CMV colitis.,0
Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.,1
"CONCLUSIONS: With increasing clinical use of terlipressin and an increasing incidence of obesity and non-alcoholic fatty liver disease-related cirrhosis, the incidence of these serious complications is likely to rise.",0
"Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.",1
Hemorrhage from a falx meningioma after internal use of low-dose aspirin.,1
OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.,1
"After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.",1
Two cases of long term dopamine D2 receptor blockade after depot neuroleptics.,0
"Woman interrupted gestation, by labour induction.",0
"OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.",1
"After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.",1
"Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.",1
"Data obtained from animal studies support the established hypothesis that lactate is distributed like other weak organic acids at steady-state; hence, alkalemia should favor a shift of lactate from the intracellular fluid (ICF) to the extracellular fluid (ECF).",0
"BACKGROUND: With the pharmacokinetic advantages of intraperitoneal chemotherapy delivery and the increased popularity of immunotherapy and gene therapy, intraperitoneal catheters have moved to the forefront as a delivery system in cancer treatment.",0
The advent of small-incision surgery has likely reduced the incidence of this complication to low levels.,0
We describe a 5-year-old girl with Ph(+) CML who received a cord blood transplant in a second accelerated phase after a very early lymphoid blast crisis.,0
"We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.",1
We report a patient who developed early onset PCP after allogeneic peripheral blood stem cell transplantation (PBSCT) from an HLA-identical sibling donor.,0
Vaccination as a triggering event for autoimmune hepatitis.,0
"Shortly after a meal, symptoms are associated with hyperglycemia (early dumping), followed by late dumping symptoms associated with reactive hypoglycemia.",0
OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.,1
Domestic dogs and cats may be another reservoir.,0
"In our experience and in other limited published data, adverse effects are rare, but prolongation of the QT interval has occurred and multiform ventricular tachycardia is likely a risk.",0
The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures.,1
Rifampin-induced hypothyroidism without underlying thyroid disease.,1
We report a patient who initially presented with localized Ewing sarcoma and later developed metastatic disease that required dose-intensified chemotherapy.,0
Clinical measures and outcomes were recorded prospectively.,0
A 75-year-old man developed bilateral lower leg edema 6 months after switching from troglitazone to pioglitazone.,1
Two cases of sirolimus-associated pneumonitis have been reported after cardiac transplantation.,1
Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.,1
"The authors suggest that in patients with corneal ulcers refractory to conventional treatment who are receiving colchicine, cessation of colchicine therapy should be considered.",1
"We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.",1
We describe the development of severe lipoatrophy in a patient treated with biphasic aspart.,0
We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.,1
A 67 year old man presented to his local dentist for restorative treatment.,0
"Two hours after ingestion of the drug, the plasma concentration of paracetamol was 3040 mumol/l.",0
The association of ergot toxicity and iliac dissection has not been previously described.,0
"The benign, self-limited nature of the color change mandates that prostaglandin E1 not be discontinued for this reason.",0
Bradycardia and congestive heart failure associated with ocular timolol maleate.,1
"However, there are some recent reports on serious adverse events, probably associated with this complementary and alternative herbal medicine.",0
"The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.",1
The morphologic findings of group 1 biopsies were those of autoimmune hepatitis in all 4 patients.,0
The patient deteriorated to Glasgow Motor Scale score (GMS) 2 and a CT scan showed signs of raised ICP.,0
"Before FAB therapy was started, the total serum DGTX concentration was 535 nmol/l.",0
Increasing the olanzapine dosage severely aggravated the symptoms of RLS.,1
We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.,1
Each was analyzed to determine a mechanism of the hypersensitivity reaction and subsequent management outcomes.,0
"We report the case of a 17-year-old male who developed chest pain, elevated cardiac biomarkers, and acute left ventricular dysfunction following a single dose of methylphenidate.",1
Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.,1
"Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.",1
"Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.",1
"In this case report, we have described a patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state.",1
We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.,1
"Because of a recurrence of paroxysmal atrial fibrillation, the dose of the drug was increased to 1.4 g/day; 24 hours later AVT with syncope developed but responded promptly to atropine.",0
It is therefore one of the most serious long-term complications of current cancer treatment and is likely to increase as longer survival rates for the primary tumour are achieved.,0
A 45-year-old man presented with deep vein thrombosis of the right leg and bilateral pulmonary embolism.,0
Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero.,1
"Although the mechanism of the pressure rise is unknown, all eyes in our series were controlled with medical therapy.",0
Amifostine has been found to significantly decrease acute and chronic xerostomia but not mucositis.,0
We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner.,1
"When a CPS perforates the transverse foramen, even if no apparent VA injury occurs during the operation, the surgeon must take care not to risk cerebral infarction because of an embolism.",0
"OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.",1
The crystalline lens was clear.,0
The clinical course is usually aggressive.,0
"Because there were no other obvious causes of renal failure in either patient, we propose that skeletal muscle ischemia developed during vasopressin infusion, followed by release of myoglobin and renal damage.",1
"When managing TLS in infancy, clinicians must consider the relative degree of renal immaturity and its predisposition toward metabolic derangements.",0
Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.,1
No changes in respiratory/hemodynamic status or oxygen saturation were observed.,0
"Because of secondary left ventricular dysfunction, digoxin was administered.",0
"Ego-alien, suicidal ideas are an extremely rare form of adverse drug reaction.",0
METHOD: A case report.,0
"With aggressive supportive therapy, including hypertonic saline administration and hemodialysis, the patient fully recovered without detectable sequelae.",0
We have concluded that opioid drugs cause bile duct obstruction in healthy persons.,0
Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.,1
Tinea incognito describes fungal infections with atypical clinical features and is usually caused by administration of steroids.,0
"Calcium intake in these infants was far below that achieved by fetuses of comparable age in utero, even though in excess of that provided by usual premature infant oral formulas.",0
Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively.,1
Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.,1
We used telmisartan to manage high blood pressure values in an HIV-positive patient with insulin-dependent diabetes.,0
Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.,1
Discontinuation of levamisole and 5-FU for a five-week period resulted in the INR falling to a subtherapeutic level.,0
Metformin-associated lactic acidosis (MALA) is a serious metabolic complication that occurs because of metformin accumulation in patients who become dehydrated or developed acute renal failure.,1
"The clinical course of a 69-year-old male with acute myelogenous leukemia is described who, while extremely leukopenic (less than 100 neutrophils/microliter) from chemotherapy, developed a cavitating pneumonia due to a gram-positive coccus, Micrococcus luteus.",0
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited disease which may comprise many endocrine and non-endocrine components.,0
"As of December 1998, only mild ectropion persisted.",0
"A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.",1
Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.,1
Clozapine has proven effective in reducing morbidity and suicidality in chronic non-remitting patients with schizophrenia.,0
Biopsies revealed an interface dermatitis with epidermal dysmaturation.,0
CONCLUSIONS: Continuous infusion of local anesthetic and opioid to a sternal fracture site using a periosteally positioned catheter led to successful analgesia and hence improved respiratory function.,0
"A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.",1
All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.,1
We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.,1
Other clinical symptoms of sarcoidosis resemble side-effects of interferon.,0
We meningitis and epidural abscess after spinal bacteraemic patient.,0
"In addition, by far the majority of bleeding complications can be treated effectively.",0
Captopril-induced lichen planus pemphigoides with pemphigus-like features.,1
We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.,1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
Temsirolimus-induced glomerulopathy.,1
Such cells were present in far greater numbers than are usually seen in untreated patients with HS or patients with HS undergoing successful bone marrow transplantation without GM-CSF.,0
Pure red cell aplasia after ABO-incompatible allogeneic stem cell transplantation in severe aplastic anemia with response to steroids: a case report and literature review.,0
"The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.",1
CONCLUSIONS: We have seen an increased incidence of acute INH neurotoxicity because of the resurgence of TB in New York City.,1
"The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.",1
Long-term prophylaxis with TMP/SMX is necessary to prevent the relapse of nocardia.,0
Thrombocytopenia has traditionally been associated with intermittent therapy.,0
A positive rechallenge occurred in seven cases (20%).,0
"DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.",1
"We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.",1
"Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with ""familial seizure disorders"" may in fact have the long QT interval syndrome.",1
"Besides hysterectomy, the treatment options for adenomyosis have been limited.",0
IFN-alpha was continued in only one patient.,0
"Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy.",1
A small initial dose of prazosin ranging from 0.5 to 1 mg has been recommended to avoid the first-dose phenomenon characterized by a sudden and severe drop in blood pressure after the administration of the first dose of prazosin.,1
"Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.",1
"Lithium neurotoxicity should be considered in Creutzfeldt-Jakob disease differential diagnosis, serial electroencephalograms being the most valuable.",1
Definitive therapy by subtotal thyroidectomy was subsequently performed and yielded good results.,0
Antidepressive treatment with fluoxetine 20 mg daily was initiated which was successful.,0
"Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.",1
"With the recent Women's Health Initiative Study demonstrating increased risk of breast cancer and cardiovascular events associated with hormone therapy, many women may resort to herbal remedies for persistent menopause symptoms.",0
"After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.",1
"Microscopic sections from a biopsy at 12 h revealed epidermal necrosis, superficial ulceration, and a mild superficial and deep perivascular lymphoid infiltrate, associated with numerous thrombi of small vessels throughout the dermis.",0
A case of recall pneumonitis induced by gemcitabine is reported.,1
"No organisms could be grown by culture of corneal scrapings for bacteria and fungi, and the condition failed to respond to topical therapy.",0
The authors report a case of a 12-year-old girl who had rare self induced photosensitive epilepsy.,0
"Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.",1
We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.,1
"At present, both patients are in the NYHA class I state and are ready to return to work.",0
We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.,1
Infection of a shunt by Mycobacterium fortuitum: case report.,0
"This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.",1
"BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.",1
Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.,1
This resulted in a comatose state with depression of some brainstem reflexes.,0
Skin rash and splinter hemorrhages from ganciclovir.,1
We report a patient with a colonic adenocarcinoma who developed hemolytic uremic syndrome after receiving 85 mg/m2 of the drug.,0
"Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.",1
"Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.",1
Lack of experience with patient reporting in real life was one of the main drawbacks in this debate.,0
Repeat PTCA was performed 10 days postdischarge due to intraluminal stent occlusion.,0
"Complete seizure control was achieved but the patient developed hallucinations, agitation and self-harming behaviour, as well as poor social contact.",0
"Therefore, we believe that screening for HBsAg is insufficient for detecting latent HBV carriers, and that investigation for hepatitis B core antibody (HBcAb) is essential.",0
"Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.",1
The mechanism of the interaction is probably inhibition of glipizide metabolism rather than protein-binding displacement.,0
Delayed hypersensitivity to flurbiprofen.,1
"In cases such as these, initial vigorous therapy, including PEEP for hypoxia, corticosteroids for possible aspiration and volume replacement for hypotension, is recommended.",0
"CASE REPORT: An East-European prostitute in Amsterdam robbed several victims, after having sedated them with clonidine solution (available as plastic ampoules of eyedrops) added to her victims' drinks.",0
"We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.",1
Severe serotonin syndrome induced by mirtazapine monotherapy.,1
We present an exceptional case in which full-thickness eyelid necrosis ensued following intralesional injection of corticosteroids in a capillary hemangioma.,0
"PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.",1
"Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with ""familial seizure disorders"" may in fact have the long QT interval syndrome.",1
"Although adverse effects are usually mild, the author reports here a case of leucocytopenia and thrombocytopenia with quetiapine treatment that required its discontinuation.",1
"Compared to patients without TD, patients with TD had a long duration of illness and clozapine treatment; all had the orolingual type of TD.",0
Cytarabine-induced cerebellar syndrome: case report and literature review.,1
"Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.",1
"Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with ""familial seizure disorders"" may in fact have the long QT interval syndrome.",1
"A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.",1
This case illustrates the importance of dermatological manifestations of systemic disease as an accessible source for diagnosis and guidance in appropriate therapy.,0
The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis.,1
"Transfusion-associated graft-versus-host disease (TA-GVHD), has rarely been reported associated with B-chronic lymphocytic leukaemia (B-CLL).",0
MATERIALS AND METHODS: Two dialysis patients with recently rejected renal allografts who were hospitalized because of fever of unknown origin are reported.,0
OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion.,1
"In addition, dermal intravascular thrombi resolved.",0
"Venlafaxine, a structurally novel antidepressant, belongs to a new generation of antidepressants--the serotonin/noradrenaline reuptake inhibitors.",0
Immunofluorescent study showed granular deposits of IgG and C3 complement along glomerular basement membranes.,0
The most common therapeutic intervention was supportive care alone (48% of patients).,0
Central nervous system imaging was negative.,0
Hepatotoxicity induced by cyproterone acetate: a report of three cases.,1
Treatment modalities have been unsuccessful and the majority of patients reported have died.,0
Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.,1
"However, several case reports have suggested that clozapine could also cause TD.",1
Milk-alkali syndrome can present serious and occasionally life-threatening illness unless diagnosed and treated appropriately.,0
OBJECTIVE: To describe a case of thrombocytopenia associated with the administration of lansoprazole.,1
"These findings are consistent with an immune-complex form of glomerulopathy in which gold is neither the antigen nor a hapten in the glomerular deposits, and they suggest the hypothesis that antibodies to tubular epithelial antigens induced by gold therapy may be a causative factor in the renal disease associated with gold therapy in rheumatoid arthritis.",1
METHODS: Four cases of essential hypertension patients (1 male and 3 females) were observed through process of therapy with indapamide and laboratory investigations.,0
Subfascial hematoma remains a rare and self-limited complication of thrombolytic therapy.,0
CASE REPORTS: Serial clinical examination of three patients was performed.,0
No other endogenous or exogenous cause for the gynecomastia could be found except for the theophylline.,1
Fifteen such patients were treated with clozapine and rerated blind to baseline symptomatology and functional level from 2 to 9 months after beginning treatment (mean = 4.2 +/- 2.1).,0
In the third patient akathisia was sufficiently controlled by dose reduction.,0
"Psoralen-ultra violet A (PUVA) photochemotherapy can be effective, but frequent maintenance therapy may be required to prevent relapse of symptoms.",0
Clostridial orthopedic infections: case reports and review of the literature.,0
"A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery.",0
Torsades de pointes were preceded and associated with marked QT prolongation and bradycardia.,0
"A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.",1
"After treatment with aripiprazole was started, the patient was inadvertently given an inactive drug, resulting in a worsening of her hemiplegic episodes, which improved again on rechallenge.",0
"Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.",1
His extensive cytotoxic chemotherapy for AML is reviewed along with a discussion of its possible oncogenic effects.,0
"CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.",1
"Since tamoxifen therapy can induce endometrial disorders, surveillance schemes of women taking tamoxifen have been recommended.",1
We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.,1
The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.,1
"In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia.",1
"In 3 consecutive cases in which a small break in the thin conjunctiva adjacent to the scleral flap was created during trabeculectomy, sodium hyaluronate 2.3% (Healon5) was intraoperatively injected into the bleb.",0
Repeat studies performed 7 months later indicated some improvements in this indirect assessment of endogenous TRH reserve capacity but a continued exaggerated TSH response to exogenous TRH administration.,0
"Angioedema, a rare side effect of carbamazepine, involves vascular leakage in dermis and subcutis mediated by immunoglobulin E and/or bradykinins.",1
Two patients are described who developed testicular swelling and pain during treatment with desipramine.,1
"Due to the increasing use of TMP-SMX in children, clinicians should be aware of this potentially life-threatening, immunemediated hypersensitivity reaction.",1
"The drugs concomitantly used were digoxin, isosorbide dinitrate, frusemide, urapidil and chlorthalidone in conjunction with oral potassium substitution.",0
"Though proteinuria and nephrotic syndrome is a rare adverse effect of IFN-beta-1b therapy, physicians treating MS patients with this agent should pay careful attention to new clinical symptoms and laboratory findings.",1
"On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.",1
"Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.",1
A Group IVC AIDS patient experienced repeated methicillin-resistant Staphylococcus epidermidis colonization and infection of his central venous access device.,0
Administration of steroid and decreasing the dose of PTU produced a good clinical response and the ANCA disappeared.,1
"Thirty-four children with acute lymphoblastic leukaemia (ALL) in relapse or resistant to initial induction received combination chemotherapy with prednisolone, vincristine, l-asparaginase, and daunorubicin.",0
"CONCLUSION: During and after IFN therapy, OCT is a useful examination technique for revealing macular edema in patients who have decreased vision.",1
Methotrexate-induced liver cirrhosis.,1
Progressive interstitial lung disease from prolonged methotrexate therapy.,1
This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.,1
"The immediate and short-term TKI side effects are well known, but the long-term side effects have not yet been clearly identified.",0
Previous reports of warfarin resistance implicated older enteral feeding products with a much higher vitamin K content.,0
"Along with normal results of a hepatorenal panel and normal serum vitamin B12 and folate levels, no metabolic or endocrinologic alterations were present to explain the nail pigmentation and dystrophic changes.",0
Seizures and transient blindness following intravenous pulse methylprednisolone in children with primary glomerulonephritis.,1
There may be a synergistic effect when corticosteroids are used in combination with chemotherapy and radiation treatment.,0
"In such cases, conservative, nonsurgical measures, such as treatment with botulinum toxin, will provide excellent results.",0
Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.,1
"It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.",1
The case was unusual in the rapidity and magnitude of hepatic enzyme elevation.,0
"Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature.",1
Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.,1
The authors report two cases of catechol-O-methyltransferase (COMT) inhibitor-induced asymptomatic hepatic dysfunction in women with Parkinson disease.,0
"In one case, the patient was successfully treated by orthotopic cardiac transplantation.",0
"Bisphosphonates (eg, alendronate) are also indicated in the treatment of osteoporosis.",0
Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.,1
The mechanisms producing ischaemia following intra-arterial injection of drugs of abuse and possible treatment are discussed.,0
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
She was transfused with four (4) units of packed cells and Zidovudine was replaced with Stavudine.,0
The increased libido disappeared after fluvoxamine was discontinued.,1
"A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.",1
"Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.",1
Successful challenge with clozapine in a history of eosinophilia.,1
It has also been seen in people with gastrointestinal diseases with malabsorption.,0
She made remarkable improvement and remains transfusion independent afterwards.,0
"While 40 mg/day of prednisolone improved hepatic dysfunction dramatically, her diabetic milieu deteriorated seriously.",1
"BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.",1
We believe this is a remarkable potentiation on record in the literature.,0
The aerosol administration allows high concentrations of tobramycin to be delivered to the site of infection with limited systemic absorption.,0
RESULTS: A single intravitreal injection of triamcinolone induced clinical and angiographic resolution of inflammatory macular oedema in all patients for varying periods of time up to 6 months.,0
Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient.,1
"The major affected sites had been treated 10 years before with Artecoll, a permanent filler containing polymethylmethacrylate.",0
Reye syndrome and juvenile rheumatoid arthritis in Michigan.,0
A case is presented in which a 68-year-old man became delirious after being withdrawn from a low dosage of alprazolam.,1
Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.,1
The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.,1
"In one of these cases, the patient, a 47-year-old man, died 10 days later.",0
Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.,1
Role of early diagnosis for a noninvasive treatment of pulmonary thromboembolism in leukemic children.,0
Agranulocytosis associated with ticlopidine: a possible benefit with filgastim.,1
"While the association of psoriasis and lupus may have been fortuitous, the temporal relationships suggest that PUVA treatment in this case may have been of pathogenetic importance in the development of the connective tissue disease.",0
Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study.,1
"However, severe limiting headaches are rarely experienced in this setting and no known therapy has been described for such a serious side effect.",0
The literature search revealed 22 cases of hypersensitivity reaction to cyclosporine.,1
"Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.",1
"CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxifen may not reduce of developing endometrial lesions, including carcinoma.",1
The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.,1
"The rate and length of administration, as well as the dose, should be carefully monitored to avoid these complications.",0
Allopurinol hypersensitivity.,1
High-density lipoprotein levels increased in both patients.,0
Of these 75% were males.,0
We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.,1
The condition responded to treatment with topical diluted steroids and antibiotics.,0
"Two 65-year-old white men with coronary heart disease, given niacin therapy for dyslipidemia for 5 months, developed intense dental and gingival pain that was associated with increases in dose and that was relieved with discontinuance of niacin treatment.",1
"Following 3 months without any symptoms, the patient had total colectomy and ileostomy.",0
Classic neuroleptic malignant syndrome (NMS) was diagnosed.,0
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.,1
"We report on a 30-year-old man with metastatic non seminomatous germ cell tumor of the left testicle to the abdomen and the lungs, who suddenly developed a bilateral spontaneous pneumothorax after the first course of salvage chemotherapy.",0
Flucloxacillin-induced aplastic anaemia and liver failure.,1
Cidofovir is an antiviral agent that has been proposed for treatment of BKVN.,0
"In this respect, we present two patients with hypertension and dyslipidaemia together with elevated serum uric acid levels.",0
A case is described in which non-convulsive status epilepticus (NCSE) prompted further investigation leading to the diagnosis of Lafora body disease (LBD).,0
"PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.",1
"Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.",1
A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.,1
Urine collections and serum samples yielded normal levels of uro- and coproporphyrins.,0
Respiratory symptoms disappeared within a mean of 60 h (48-96 h) of treatment.,0
This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.,1
"Liver abscess in patients with a VP shunt should be considered a possible abdominal complication of the VP shunt, and may be caused by unusual pathogens.",0
Youssef's syndrome: an appraisal of hormonal treatment.,0
Several such HBV reactivations were reported after combined rituximab and multiagent chemotherapy for B-cell lymphomas.,1
"Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.",1
Currently available antiviral agents have been unsuccessful in halting its progression.,0
The technique of serum free level measurement and illustrative examples of specific cases are provided to document the usefulness of this invaluable laboratory test.,0
Adhesions to manufacturer's trademark on the surface of a posterior chamber lens.,0
Therapy with IFN-beta has rarely been associated with the development of autoimmune disorders.,1
"In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.",1
Methylphenidate (Ritalin)-associated cataract and glaucoma.,1
"Two weeks later the patient presented with acute oliguric renal failure, symptomatic hyperkalemia and metabolic acidosis, necessitating emergency dialytic treatment.",0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.",1
We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.,1
"The ampules of tranexamic acid (500 mg/5 mL) and bupivacaine (5 mg/mL, Merck, Darmstadt, Germany) were similar in appearance.",0
Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy.,1
"Clearly, patience is important during hepatitis C therapy in order to avoid unnecessary examinations and to promote successful outcomes.",0
We report a 13 year-old male who developed life-threatening anaphylaxis early in the course of Increlex therapy.,1
Co-trimoxazole red cell aplasia in leukaemia.,1
A 36-year-old white man had both acute intermittent porphyria and long-standing idiopathic grand mal seizures.,0
"We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).",1
"Two of the three cases had received blood transfusions, and attention is drawn to the possibility that mitomycin C may sensitise the kidneys to minor mismatches.",0
Liver transplantation for fulminant hepatitis related to nevirapine therapy.,1
The patient was urged to discontinue her use of deodorants.,0
The first cycle of her CHOP regimen was initiated (day 1) in our outpatient unit; she was then discharged home.,0
Drug induced acute parotitis is a very uncommon complication reported with a few drugs only.,0
"No fever, elevated WBC count or significant electrolyte imbalance was found.",0
Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.,1
"We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.",1
Since the depressive symptoms returned sertraline medication was initiated.,0
"In this article, we present the case of a vitiligo patient who was admitted to our facility with an intense burn after the topical use of 8-methoxypsoralen solution as a suntanning agent.",1
The gastrointestinal arterial bleeding from the penetrating aneurysm presented a life-threatening situation.,0
"Gamma-hydroxybutyrate (GHB) is best known as a recreational depressant drug, whose use has also been implicated in drug facilitated sexual assault cases.",0
"His serum carbamazepine concentration was 3.9 microg/mL (reference range, 4-12 microg/mL), and his serum ammonia concentration was 127 microg/dL (reference range, 19-60 microg/dL).",0
A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.,1
Intestinal pseudo-obstruction was a prominent feature in the patient in this study.,0
Disopyramide-induced heart block.,1
"Four months after cessation of treatment, a severe acne with comedones, papules, pustules, and small cystic elements broke out.",0
"After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.",1
"During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.",1
"An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.",1
"CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.",1
"In addition, the development of tardive dyskinesia and its subsequent amelioration with a depot form of a high-potency neuroleptic are discussed in relation to these disorders.",0
"They seemed to involve multiple aetiological factors, such as autoimmune thyroid disease, the toxic and immunomodulatory roles of lithium and perhaps genetic and dietary factors.",1
We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.,1
We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).,1
Massive plasmocytosis due to methimazole-induced bone marrow toxicity.,1
"Cutaneous rashes and eruptions can be caused by many medications, including carbamazepine.",1
"However, the chlorpromazine equivalent dose of antipsychotics and the number of total psychotropics were significantly reduced from 957 to 722 mg/day (p<0.0001) and from 4.0 to 3.2 (p<0.0001), respectively.",0
"A thorough hematologic examination revealed von Willebrand's disease, which the patient was not aware of.",0
During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.,1
The influence of diuretic therapy in combination with lithium is felt to enhance the risk of intoxication.,0
Endoscopy demonstrated oesophagitis and a benign oesophageal stricture.,0
Theophylline intoxication following viloxazine induced decrease in clearance.,1
We report on two cases in which mother-infant PIVKA concentrations were measured at birth after chronic anticonvulsant therapy during pregnancy.,0
"We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.",1
Our series of 3 patients supports a causal connection between bleomycin and scleroderma.,1
The major side effect of infliximab is infection.,1
The combination therapy of interferon alpha and ribavirin was given to a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha.,0
Herein we document the unusual association of focal nodular hyperplasia with use of a synthetic anabolic androgen.,0
OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).,1
"A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.",1
Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis.,1
"Neuroleptic malignant syndrome is an uncommon and potentially fatal idiosynchratic reaction of antipsychotic drugs, in which the clinical scenario encompass muscular rigidity, hyperthermia, autonomic dysfunction, altered consciousness, high creatinine phosphokinase levels, and leukocytosis.",0
OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.,1
"CASE SUMMARY: A 61-year-old white male patient (weight, 90 kg) was diagnosed with CML in March 2006 at the Division of Hematology, University of Rome ""Tor Vergata,"" Rome, Italy.",0
"From these data, acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d-penicillamine therapy.",1
"Dopaminergic drugs, particularly dopamine agonists, play an important role in triggering these nonmotor symptoms.",0
"Sirolimus has been widely used in renal transplantation, and its use in heart transplantation is increasing.",0
We present a case of a 58-year-old female patient with Graves' disease who developed AA in the third exposure to methimazole (MMI).,1
Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.,1
"On day 13, a 24-hour urine collection had a protein excretion of 3151 mg.",0
"Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.",1
"Five months after initiating mirtazapine therapy, she developed symptomatic hyponatremia.",1
The median age was 31 yr (range 2-93).,0
"This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.",1
DISCUSSION: Phenolphthalein is the active ingredient in several over-the-counter laxative preparations and has only rarely been reported to cause TEN.,1
Patients with metastatic breast adenocarcinoma showed complete responses in both treated nodules after ECT.,0
Our case re-emphasizes the need for investigation of factors precipitating ARF in children with idiopathic NS.,0
Psychotic disorder associated with isoniazid.,1
"Recurrent unilateral, throbbing, frontal headaches should be referred to as facial migraine.",0
Hepatitis following cimetidine administration.,1
"Recombinant human growth hormone (rhGH) therapy in Prader-Willi syndrome (PWS) causes increased basal metabolic rate and oxygen consumption, and hence increased ventilatory load.",0
"RESULTS: Despite treatment with various neuroleptics, the psychosis resolved only when the interferon/ribavirin were discontinued.",0
"A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias.",0
We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.,1
Toxoplasmosis retinochoroiditis after photodynamic therapy and intravitreal triamcinolone for a supposed choroidal neovascularization: a case report.,0
Lymphangiomyomatosis: hormonal implications in etiology and therapy.,0
Development of Crohn's disease in a patient with multiple sclerosis treated with copaxone.,1
Eighty infants with proliferative retinopathy of prematurity (ROP) were treated with peripheral retinal cryoablation.,0
The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.,1
There was a striking temporal relationship between the administration of antibiotics or allopurinol and exacerbations of the disease.,0
"Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.",1
"Uniquely, however, relief of peptic symptoms induced by hypergastrinemia is now available from acid-suppressive drugs such as proton-pump inhibitors (PPIs).",0
"By now, there are no reports in literature of agranulocytosis caused by tumur necrosis factor-alpha blockers.",0
He began treatment with dopamine agonists bromocriptine mesylate (in 1984) and pergolide mesylate (in 1989).,0
"Interestingly, continuation of the interferon therapy in the presence of a mild-to-moderate exacerbation of sarcoidosis may be safe in a minority of patients with noncritical organ involvement.",0
"In addition, a 31-year-old man with obsessive-compulsive disorder developed RBD soon after starting fluoxetine therapy, which persisted at PSG study 19 months after fluoxetine discontinuation.",1
"This report describes a male college student who experienced akinesia lasting almost 3 weeks following withdrawal from relatively brief, low-dose neuroleptic treatment.",0
"Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as ""red man syndrome"" and anaphylaxis.",1
ATT had to be stopped because of this adverse drug reaction.,0
"We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.",1
CONCLUSIONS: Intrathecal baclofen can impair sexual function and ejaculation in some patients.,1
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
Exacerbated radiodermatitis and bilateral subdural hemorrhage after whole brain irradiation combined with epidermal growth factor receptor tyrosine kinase inhibitors for brain metastases in lung cancer.,0
We postulate that the bolus of sulprostone resulted in possible coronary spasm that resulted in cardiac arrest.,1
Successful treatment of rhegmatogenous retinal detachment secondary to globe perforation during peribulbar injection in a case of sympathetic ophthalmia.,0
Percutaneous radiofrequency thermal ablation (RFA) is considered an effective technique for providing local control in the majority of Hepatocellular carcinoma (HCC) patients.,0
"For one patient, thrombocytopenia due to autoantibodies to PEG-rHuMGDF developed shortly after PEG-rHuMGDF administration and persisted until chemotherapy was administered.",0
Discontinuation of the drug resulted in total resolution of the clinical and radiologic abnormalities.,0
CASE DESCRIPTION: A 37-year-old woman was started on weekly interferon beta-1a (IFN beta-1a) following a diagnosis of multiple sclerosis (MS).,0
Spontaneous bacterial peritonitis induced by intraarterial vasopressin therapy.,1
Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity.,1
Chest X-ray revealed a solitary pulmonary nodule.,0
"In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.",1
"He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.",1
"In one case, disulfiram was the only potential teratogen exposed to the fetus.",1
"RESULTS: Careful blood cell monitoring showed a pronounced diurnal variation of WBC (2.9-4.2x10(9)/l in the morning and 3.6-7.1x10(9)/l in the afternoon) and granulocytes (0.8-1.4x10(9)/l and 2.9-5.5x10(9)/l, respectively).",0
Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity.,0
Case 2.,0
A review of the literature of 68 case reports of acute leukemia following ovarian cancer is presented and 3 new cases are reported.,0
Risk of abuse of diphenhydramine in children and adolescents with chronic illnesses.,0
Magnetic resonance imaging may be useful in these cases to confirm the diagnosis of WE.,0
He underwent removal of the allograft and implantation of another liver.,0
Fatal hepatic failure caused by chemotherapy-induced reactivation of hepatitis B virus in a patient with hematologic malignancy.,0
"A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported.",1
Microangiopathic cytokines released in response to the GVHD and infection may damage the intima of microvessels that were previously injured by the two BMT.,0
"In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.",1
"The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.",1
"This myoclonus is considered to be a new form of spinal reflex myoclonus, because the abdominal myoclonic jerk seems to trigger another myoclonic jerk involving the paraspinal muscles.",0
Eighty-four percent of patients reported an increase in their sense of well-being.,0
"Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache.",1
Specimens were evaluated by light and electron microscopy.,0
BACKGROUND: Cloxacillin is a semisynthetic penicillin widely used in nonmethicillin resistant Staphylococcus aureus infections.,0
"In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.",1
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.,1
Catatonia associated with disulfiram therapy.,1
Sulfadiazine crystalluria revisited.,1
She had been on Copaxone 20 mg/day treatment for 2 years when she first exhibited gastrointestinal symptoms.,1
Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.,1
"In one patient this resulted in an ischemic and necrotic digital ulcus, necessitating surgical amputation.",0
Hepatotoxicity of hycanthone in patients with metastatic breast cancer.,1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.",1
"A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.",1
"Carmustine (BCNU), a nitrosourea derivative, is an antineoplastic agent used recently for the treatment of human solid tumors and lymphomas in high doses with autologous bone marrow transplantation.",0
Fungal septicaemia is a serious and potentially fatal condition.,0
"Camptocormia, a new side effect of sodium valproate.",1
"After substitution of a standard diet starting August 21, we found significant decreases of total cholesterol from 725 mg/dl to 194 mg/dl and triglyceride from 4680 mg/dl to 550 mg/dl within 37 days.",0
Effects of highly overdosed indomethacin in a preterm infant with symptomatic patent ductus arteriosus.,0
"Although evidence of congestive heart failure was evident, dialysis was avoided without significant sequelae.",0
"DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.",1
"Careful donor evaluation before transplantation, unusually early presentation of mycosis leading to anastomotic renal artery disruption, the histopathologic findings of the grafts, and the absence of Candida infection in the liver and heart recipients make us believe that exogenous contamination of the grafts occurred during donor procedure, kidney processing, or at transplantation.",0
"In addition, patients with clinical signs suggestive of NMS should be monitored more carefully.",0
"Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.",1
"The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.",1
The site of thrombosis and the chronological relationship with the IIR implicates a hypersensitivity to infliximab in the causation of the venous thrombosis in this case.,1
Phenytoin-induced hypersensitivity reactions.,1
Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.,1
Many combinations of methotrexate and folic or folinic acid have been used to limit the side effects of methotrexate therapy in psoriasis or psoriatic arthropathy.,0
This report describes a method of applying photodynamic therapy in the biliary tract by using accessories available in the United States.,0
DISCUSSION: Neonates may be at particular risk for TLS given their immature renal function and its predisposition toward metabolic derangements.,0
"In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.",1
"Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.",1
Patients were followed up every 2 weeks after the laser treatment.,0
"To the best of our knowledge, this is the first case of lithium-associated CDI and NDI presenting concurrently.",1
No subjective discomfort was reported.,0
"Reaccumulation of hemothorax occurred over the 48 hours following drain removal, necessitating insertion of a second drain, which removed 1400 mL of blood-stained fluid.",0
Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.,1
CASE: A malignant mixed mesodermal tumor was diagnosed in a 64-year-old woman with a bicornuate uterus while she was taking raloxifene for osteoporosis prevention.,1
Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.,1
At that time anti-tuberculous agents were also being administered for presumed tuberculosis.,0
A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy.,1
A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma.,1
"PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.",1
The degree of emanating clinical events also conforms to status of the aflatoxicosis.,0
She did not use contact lenses postoperatively.,0
This article reports the case of an otherwise healthy patient who experienced permanent sensorineural hearing loss after a brief course of naproxen and reviews the literature on NSAID-related permanent sensorineural hearing loss.,1
Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.,1
"However, all Brown Norway rats that received estradiol treatment developed pyometra, whereas none the Sprague Dawley or control Brown Norway rats did.",0
Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.,1
Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.,1
"A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.",1
"Although there were few cases in which psychotropic medication was effective against coprophagia, we encountered a patient with schizophrenia in whom coprophagia rapidly disappeared after treatment with perospirone, a novel atypical antipsychotic drug of the serotonin-dopamine antagonist (SDA) type.",0
"His symptoms included bradycardia, hypotension, hypothermia, pallor, cyanosis, and impaired consciousness.",0
"We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis.",1
Our results indicate that pharmacokinetic variability may contribute to either severe myelotoxicity or therapeutic failures.,0
Maximum improvement may not be reached before 8 weeks.,0
"On the third day, zafirlukast (20 mg twice daily) was reintroduced to the regimen, and the theophylline therapy was continued.",0
Piloerection induced by replacing fluvoxamine with milnacipran.,1
Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.,1
Vinblastine was excluded from the new regimen.,0
Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?,1
We report on a patient with acromegaly who developed severe drug-induced hepatitis during combined treatment with the long-acting somatostatin-analog octreotide and the GH receptor antagonist pegvisomant.,1
Multiple mechanisms for ciprofloxacin-induced nephrotoxicity have been proposed.,1
Paraplegia following prophylactic intrathecal cytosine arabinoside (Ara-C) is described in a patient with acute myelogenous leukemia in remission who received doses of 100 mg/m2/d for 5 consecutive days.,1
This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.,1
Thrombocytosis induced by enoxaparin has been reported as a rare adverse effect of this medication in adults.,1
Most cases are associated with phenylpropanolamine use.,0
"Moreover, antibody therapy does not take effect immediately, as is understandable in view of the mechanism of action.",0
"Eleven days after TAE, he developed suppurative cholangitis and multiple organ failure.",0
"However, these patients may be admitted to an intensive care unit (ICU) with complications of Wolff Parkinson White (WPW) syndrome; for example post cardiopulmonary arrest or WPW as a co-morbidity.",0
"According to the Naranjo et al. adverse-reaction probability scale, enoxaparin was the probable cause of hepatotoxicity in this patient.",1
Dental and craniofacial characteristics in a patient with leprechaunism treated with insulin-like growth factor-I.,0
"Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.",1
Pregnancy complicated by endodermal sinus tumor of the ovary is extremely rare.,0
"We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.",1
Edema associated with ibuprofen therapy.,1
"This case demonstrates that itraconazole may be effective treatment for dermatophytosis, even in immunocompromised hosts, and that there is no cross-reactivity between ketoconazole and itraconazole.",0
"This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.",1
"In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.",1
"Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.",1
Bisphosphonates inhibit bone turnover and result in increased bone-mineral density.,0
The harlequin color change and association with prostaglandin E1.,1
"The leukemic blasts were examined by morphological, immunohistochemical, cytogenetic, and molecular genetic analyses.",0
The site of thrombosis and the chronological relationship with the IIR implicates a hypersensitivity to infliximab in the causation of the venous thrombosis in this case.,1
It is important to keep a high index of suspicion with regard to DIAN since it is usually rapidly reversible.,0
None of the patients had loco-regional recurrence.,0
"RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.",1
Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.,1
CONCLUSIONS: The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis.,1
The response to antimicrobial therapy was better in the more recent cases.,0
Erythroid engraftment was successful with primary steroid treatment.,0
"We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib.",1
A skeletal X-ray showed huge amounts of periarticular TC.,0
Intravenous cimetidine administered q8h offers a safe and cost-effective approach to H2-receptor blockade and reduction of gastric acid secretion in patients who are temporarily unable to take oral medication.,0
"To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.",1
"The pathogenesis of the porphyria is not clear; however, cyclophosphamide is a substrate for cytochrome P450, and may produce metabolites that destroy this protein.",0
"A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.",1
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.,1
We present a case in which a bolus intravenous injection of sulprostone 30 micrograms was administered to treat postpartum haemorrhage during caesarean section.,0
A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.,1
We present a patient who had a superior sagittal sinus thrombosis in addition to his PDPH.,0
"CASE SUMMARY: A 71-year-old woman with a history of malignant mixed mesodermal tumor involving the uterus, cervix, and vagina was admitted because of local recurrence.",0
Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.,1
Both patients received prolonged treatment with high doses of intravenous methylprednisolone.,0
Long-term treatment with high-dose corticosteroids exposes patients to potentially serious adverse effects.,0
An immediate hemolytic reaction induced by repeated administration of oxaliplatin.,1
"In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association.",1
"After 39 hours on argatroban, the infusion was stopped when minor bleeding was observed with a concurrent activated partial thromboplastin time (aPTT) of 100 seconds.",1
Four cases of adverse experiences with clonidine are described.,1
For treatment of this condition he was given androgens and corticosteroids.,0
"A review of the literature indicates that even when given at much higher doses than are needed for treating heroin or alcohol abusers, there is no evidence that NTX causes clinically significant liver disease or exacerbates, even at high doses, serious pre-existing liver disease.",0
We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.,1
CASE REPORTS: Case 1.,0
Gemcitabine-associated hemolytic-uremic syndrome.,1
"Celecoxib can be administered as palliative treatment to affected birds, but as with any nonsteroidal anti-inflammatory drug, COX-2 inhibitors should be used cautiously because they can adversely affect renal function by decreasing renal prostaglandin synthesis.",0
We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).,1
INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.,1
Mucopurulent conjunctivitis and exposure keratitis developed in several patients and spontaneous corneal perforation developed in one.,0
"She was treated with neoadjuvant chemotherapy and developed an accelerated SSc syndrome with pericarditis and cardiac tamponade, with lethal results.",0
"Seven days later, she had full-blown, severe hepatitis.",0
Dystonia associated with carbamazepine administration: experience in brain-damaged children.,1
Cardiac arrest following use of sumatriptan.,1
A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.,1
BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.,1
"The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.",1
"A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.",1
Only 3 cases of imatinib-induced tumor lysis syndrome have been reported.,1
"We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.",1
Both grafts were successful and remained clear.,0
CONCLUSIONS: All primary eye care clinicians should be aware of this new and unique clinical presentation and be prepared to recognize it quickly and treat it appropriately.,0
"About 30% of patients have an initial remission on steroids alone, but most require some form of cytotoxic chemotherapy.",0
Cluster-like headache after surgical crystalline removal and intraocular lens implant: a case report.,0
"Treprostinil is labeled for treatment of pulmonary hypertension with New York Heart Association (NYHA) Class II, III and IV symptoms.",0
"Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.",1
"Given tardive dyskinesia (TD), clinicians and interdisciplinary teams should remain alert to the following client profile: (1) prescribed phenobarbital (or primidone), (2) prescribed neuroleptics, especially at high dosages, to control maladaptive behaviors, (3) failure of neuroleptic gradual minimal effective dose attempts, and (4) possible presence of behavioral procedures, especially intrusive procedures, to control maladaptive behaviors.",0
The possible underlying pharmacological mechanisms of this clinical reaction lend support to the cholinergic-adrenergic balance hypothesis of affective disorders.,0
"A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.",1
Arsenic trioxide has recently been introduced as a promising new agent to treat refractory acute promyelocytic leukemia (APL).,0
We conclude that prolonged l-asparaginase therapy in combination with an anthracycline might well be used in initial or consolidation therapy for childhood ALL.,0
Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.,1
We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.,1
Transfusion-related acute lung injury.,0
The management of the patient's withdrawal symptoms is described.,0
METHODS: Three patients with apparent itraconazole-induced liver injury were studied.,1
Pulses were administered after the injection of 1% lidocaine solution around the treatment site.,0
"In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.",1
"As expected, we identified few successful cases of switches from clozapine in our search of the literature.",0
The diagnosis was initially thought to be a recurrence of idiopathic thrombocytopenic purpura (ITP) that had initially occurred in 1992 and had required splenectomy.,0
"Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab.",1
PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.,1
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.,1
"CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.",1
"Naproxen, the most common offender, has been associated with a dimorphic clinical pattern: a PCT-like presentation and one simulating erythropoietic protoporphyria in the pediatric population.",1
It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.,1
Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.,1
"Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed.",1
"BACKGROUND: Aside from the direct ocular manifestations of tuberculosis, significant vision loss can occur during treatment with agents that have potential ocular toxicities.",0
Aggressive endometrial carcinoma in a breast cancer patient treated with tamoxifen with normal transvaginal ultrasonography.,1
STUDY DESIGN: Case reports are presented of three premature infants (mean gestational age 27 weeks) cared for in the intensive care nursery in whom clinically significant septal hypertrophy and left ventricular outflow tract obstruction developed during dexamethasone treatment for bronchopulmonary dysplasia.,1
"CONCLUSIONS: Although mirtazapine offers clinicians a combination of strong efficacy and good safety, we suggest bearing SS in mind when prescribing this drug, especially in frail, elderly patients with underlying chronic conditions.",1
CASE SUMMARY: A 25-year-old postpartum white woman developed multiple watery stools and abdominal cramping on day 6 of therapy with clindamycin vaginal cream for bacterial vaginosis.,1
"Ciprofloxacin is among the standard treatments for infected ischemic ulcers; in the rare case of ciprofloxacin-induced hemorrhagic vasculitis, it might be interpreted as progression of infection, instead of a complication of the treatment, thus leading to faulty diagnosis and treatment.",1
A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.,1
"We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).",1
"This constellation of biochemical abnormalities mimic Type 5 Bartter's syndrome, where there is activating mutation of the calcium sensing receptor in the thick ascending loop of Henle and the distal tubule.",0
We report the first case of fulminant hepatic failure associated with its use.,0
Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.,1
"Following administration of the antidote, digoxin immune antigen binding fragments (Fab), SDC monitoring is hampered by assay-related problems because of the presence of Fab in the serum.",0
"The dog underwent multiple operations involving internal fixation of the fractured scapula with wire and a plate, followed by extensive chemotherapy with antibiotics and prednisolone.",0
Both of the Campylobacter jejuni isolates were resistant to cotrimoxazole and ciprofloxacin.,0
"On the first occasion she experienced arterial fibrillation secondary to a severe episode of hypotension following local anaesthesia, while on a course of beta-blockers.",0
"Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.",1
Rechallenge with a different beta-lactam antibiotic has not been shown to consistently cause recurrent leukopenia.,0
"A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.",1
RESULTS: Best corrected visual acuity before injection was 6/60 in the left eye.,0
Simvastatin therapy was resumed and resulted in a prompt and severe return of his symptoms.,0
We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).,1
A syndrome of increased affect in response to risperidone among patients with schizophrenia.,1
"Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.",1
Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.,1
DNA-based analysis of amniotic fluid (AF) from at-risk pregnancies has been suggested as an adjunct/substitute for traditional culture.,0
The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.,1
A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.,1
"Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.",1
The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.,1
Antiepileptic drug hypersensitivity syndrome: in vitro and clinical observations.,0
"Dipyrone, also known as metamizole, is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis.",1
Well-known signs of methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration.,1
The role of anticoagulation with heparin is controversial in the absence of any controlled studies.,0
"In contrast, the LMW heparinoid Org 10172 (Organon, Oss, The Netherlands) did not cause platelet activation.",0
Upper tract urothelial malignancy after cyclophosphamide therapy: a case report and literature review.,1
Here we report an unusual case of mixed Wilms' tumour and angiosarcoma in a 38-year-old female patient who presented with haematuria and right lower back pain.,0
"About 44% of the patients had gastric adenocarcinoma, and 82% had received mitomycin C.",0
"Four of these were derived from a study of 100 schizophrenic patients on maintenance neuroleptic medication, thereby giving a prevalence of 4% in such patients.",0
"Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.",1
Hormone therapy in men and risk of cardiac allograft rejection.,0
CONCLUSIONS: MMF is a potent immunosuppressive agent in liver transplantation.,0
An unusual cause of burn injury: unsupervised use of drugs that contain psoralens.,1
Graft versus host-like illness in a child with phenobarbital hypersensitivity.,1
"We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.",1
Prolonged echoviral meningitis in a cancer patient with normal serum immunoglobulins.,0
Initial single rinsing with phosphate does not produce corneal calcification (P=0.134).,0
Hepatic Sinusoidal Obstruction Syndrome in a child after chemotherapy for medulloblastoma.,0
Motor cortex excitability was studied by single and paired TMS and MEPs were recorded from FDI.,0
"Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.",1
It completely remitted following withdrawal of phenelzine combined with a low dose of haloperidol (1 mg/day) for several days.,0
"DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.",1
Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.,1
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).,1
The epiphyseal myeloid cells were reduced or sometimes eliminated during id injection.,0
"Since tamoxifen therapy can induce endometrial disorders, surveillance schemes of women taking tamoxifen have been recommended.",1
"We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).",1
Serologic responses were highly suggestive of T. gondii as the etiology in all cases; other causes (CMV retinitis and syphilis) were actively sought and were not found.,0
Thrombocytosis associated with enoxaparin: A very rare cause in newborns.,1
"This report describes an individual with mental retardation who experienced behavioral exacerbation associated with clonazepam prescribed at 2 mg/day (0.02 mg/kg/day) to treat aggression, self-injurious behavior, property destruction, and screaming, which was measured with a 15-minute partial interval recording measurement method.",1
"The patient was hospitalized in October, 1974, with signs and symptoms of right ventricular outflow obstruction and arrhythmia, and cardiac workup established the presence of a right ventricular tumor.",0
METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.,1
This represents a significant improvement over normal body clearance (4.7 ml/min/kg) in pediatric patients.,0
"A pharmacokinetic interaction between the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine, was noted in a patient treated for major depression and obsessive-compulsive disorder.",0
The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.,1
Anaphylaxis to calcitonin.,1
Massive gastrointestinal hemorrhage in an immunosuppressed man due to gastric Kaposi's sarcoma.,0
"Gingival hemorrhage is recognized as a symptom of MDS, a rare group of potentially fatal hematological disorders, but it has not previously been documented as a presenting sign.",0
"A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.",1
"The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy.",1
PURPOSE: To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation.,0
Overall gains and no change in bodyweight were observed in 83% of patients.,0
"However, prolongation of 5-FU half-life and an increase in INR have been reported with the concurrent use of 5-FU and warfarin.",1
Improved awareness and rapid treatment of the second patient had a favorable outcome with no sequelae.,0
Tuberculous uveitis after treatment with etanercept.,1
"After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.",1
"We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium (Depakote), resulting in serum concentrations 10 times greater than the therapeutic range.",1
Diabetes mellitus type 1 in five military aviators: flying with insulin.,0
Ciclosporin was effective at controlling all symptoms of SNHL.,0
Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade.,0
Eosinophilic cystitis is a rare and poorly understood disorder.,0
Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported.,1
"Using micro broth dilution technique the isolated strain was shown to be most susceptible to penicillin G, cephalothin, and ciprofloxacin, with minimal inhibitory concentrations of 0.00025, 0.004, and 0.002 mg/l, respectively; and with minimal bactericidal concentrations (99.9% killing) of 0.25, 0.12, and 0.008 mg/l, respectively.",0
We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.,1
"Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.",1
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
Use of high-dose intravenous immunoglobulin in systemic lupus erythematosus: report of three cases.,0
CONCLUSION: Squamous metaplasia in these cases appears to be a consequence of progestin therapy.,1
"Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.",1
Neostigmine appears to be useful in reversing ileus caused by anticholinergic drug overdose.,0
"He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.",1
Punctate keratitis with keratinization of the cornea led to complete loss of vision.,0
"Systemic disease, most commonly renal dysfunction, preceded all 30 reported cases of acyclovir neurotoxicity.",1
"There was resolution of the inflammation; however, bullous keratopathy was subsequently noted in the cornea.",0
Seizures associated with ofloxacin therapy.,1
"We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.",1
"Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.",1
"We suggest that nicotinic acid was the cause of his liver disease, that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure, and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity.",1
"In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.",1
"Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.",1
"For patients receiving hemodialysis (HD) who are exposed to gadolinium, the Federal Drug Administration (FDA) recommends HD to remove this contrast agent in order to minimize the risk of NSF.",0
We present a case of mucormycosis primarily affecting the paranasal sinuses in a 51-year-old man with a kidney allograft.,0
DESIGN: Observational case report.,0
OBJECTIVE: To describe a probable case of transient global amnesia caused by propafenone.,1
Bilateral inguinal scrofuloderma during steroid therapy in a patient with bullous pemphigoid.,0
"The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases, but coincidence cannot be excluded.",1
Diagnosis of lipoid pneumonia was made by diagnostic bronchoscopy with bronchoalveolar lavage (BAL).,0
Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.,1
"Two case reports are presented: the first with clozapine challenge after eosinophilia, the second under clozapine treatment and no previous haematological side effects.",0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon.",1
BACKGROUND: The number of leishmaniasis cases associated with immunosuppression has increased regularly over the past 20 years.,0
This article describes a patient with suspected ciprofloxacin-induced interstitial nephritis.,1
"Lithium neurotoxicity should be considered in Creutzfeldt-Jakob disease differential diagnosis, serial electroencephalograms being the most valuable.",1
Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation.,1
"The common risk factor of both of these two drug-induced ILDs is idiopathic interstitial pneumonia, but ILD in a patient with radiation fibrosis has not been previously reported.",0
A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.,1
"We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.",1
Hepato-biliary abnormalities secondary to ceftriaxone use: a case report.,1
At 12 months there was no evidence of recurrence though new nodular BCCs and SBCCs had developed elsewhere on his upper torso.,0
A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements.,1
DESIGN AND METHODS: A specimen of resected TSHoma tissue from our case was immunohistochemically examined for expression of somatostatin receptor 2A (SSTR2A) and PPAR gamma.,0
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
"This case had radiation fibrosis, so we suggest that radiation fibrosis may be another contributor of the occurrence of ILD in patients taking erlotinib.",1
"When tested in ferrets, the mutant virus had less virulence than the parent; however, it had a growth preference over the parent in zanamivir-treated animals.",0
The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed.,1
We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.,1
Ileal biopsy revealed an erosive enteritis with mucosal inflammatory infiltrate and disruption of the surface epithelium.,0
"When DSCG was withdrawn, urticaria vanished and the child remained symptom-free.",1
Triiodothyronine-induced thyrotoxicosis in ophthalmic Graves disease.,1
"His illness was also characterized by a palpable spleen tip, marked lower extremity and scrotal edema, and generalized lymphadenopathy.",0
"Ten months after discontinuing tamoxifen, she underwent exploratory laparotomy for a right adnexal mass suspected as ovarian malignancy.",0
In view of the temporary symptomatic action and the seriousness of certain side-effects of desmopressin we recommend that desmopressin be used with caution in childhood enuresis.,0
"The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.",1
Little is known about the prevalence of genotypes and implications for screening in children.,0
Nodular scleritis following alendronate therapy.,1
Amantadine was therefore discontinued.,0
Meningitis can be caused in experimental performing a lumbar puncture (LP) after bacteraemia.,0
Cephalexin rash in infectious mononucleosis.,1
CONCLUSIONS: Intravitreal bevacizumab appears to be an effective tool in the immediate control of neovascularization following L-CRA for nonischaemic CRVO.,0
"Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.",1
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.,1
Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.,1
CASE DESCRIPTION: A 59-year-old man with known neurocysticercosis developed a large cerebral infarction during praziquantel therapy.,1
"This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.",1
Complications in the use of prochlorperazine.,0
A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.,1
"Infliximab and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.",1
"The pupil dilated more widely following this procedure, resulting in an improvement in the patient's visual field.",0
"Hairy cell leukemia, a low-grade B-cell lymphoproliferation, has not been recognized as part of the PTLD spectrum.",0
Persistent idiopathic facial pain following dental implant placement: a case report.,0
"The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.",1
"Routine endomyocardial biopsy showed acute rejection of less than grade Ib, and the patients were discharged on the 65th and 46th postoperative day, respectively.",0
Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy.,1
Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.,1
Prominent positive U waves appearing with high-dose intravenous phenylephrine.,1
Renal toxicities have been reported in less than one percent of the patients receiving ciprofloxacin therapy.,1
"Physicians should therefore be aware of its occurrence and carefully monitor serum levels of CPK, GOT and GPT during the treatment of diabetes insipidus with clofibrate, especially in patients with associated hypothyroidism, latent or overt, which possibly favors the development of myopathy.",1
Prominent EPS developed soon after initiation of an atypical neuroleptic agent.,0
Histologic evaluation was also performed before treatment and in selected patients during treatment.,0
We confirmed varicella zoster virus using a direct fluorescent antibody test.,0
He denied aspirin or non-steroidal anti-inflammatory drug use.,0
We present a case of photo-onycholysis in a patient treated with doxycycline for acne vulgaris.,1
Improvement in cholestasis associated with total parenteral nutrition after treatment with an antibody against tumour necrosis factor alpha.,0
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.,1
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
"Until the mechanism of the formation of rickets in small premature infants is clarified it is recommended that supplemental calcium and vitamin D be given to all premature infants receiving parenteral nutrition, and that periodic x-rays be obtained to detect the development of rickets.",0
Detection of cytomegalovirus DNA from cytomegalovirus corneal endotheliitis after penetrating keratoplasty.,0
The clinical course of this case indicates that IFN therapy precedes IDDM.,0
Sedation improved at least moderately in 5 of the patients and mildly in 1 after they began taking donepezil.,0
Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.,1
We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.,1
Haemophagocytic lymphohistiocytosis (HLH) is an uncommon disease with a high fatality rate.,0
CLINICAL FEATURES: A 61 yr old man with severe mitral regurgitation and chronic obstructive lung disease underwent surgery for mitral valve repair.,0
Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.,1
We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.,1
This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy.,1
The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.,1
Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.,1
"The septal defect, repaired surgically by Hazeltine's method healed completely within 6 weeks.",0
"This is the second report to describe such findings, which are attributed to damage of the inferior division of the third cranial nerve secondary to manipulation of adjacent ethmoid tissues.",0
"This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.",1
This has most commonly been a bone complication with little if any soft tissue involvement.,0
Cephalosporins are most likely associated with Vitamin K deficiency.,1
"Administration of cation-exchange resin such as sodium polystyrene sulphonate (Kayexalate) is effective in lowering plasma potassium, although complications following oral or rectal administration are reported in newborns.",0
"A 34-year-old man presented 4 months after renal transplantation with a 1-week history of epigastric pain that decreased in supine position, increased while sitting, and further increased when standing or walking.",0
"The former is thought to be related to central nervous system dopaminergic hyperactivity, while the latter is known to be related to dopamine deficiency.",0
The oligohidrosis caused by zonisamide was reversible in that the patient regained the ability to sweat within 2 weeks of the cessation of drug administration.,1
CONCLUSION: We conclude that stanozolol is a safe and effective treatment of the cutaneous manifestations of cryofibrinogenemia.,0
"A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.",1
A 71-year-old woman who had critical cerebral ischemia secondary to a carotid artery occlusion was receiving high-dose intravenous phenylephrine for a trial of hypertensive therapy.,0
A case is reported in which posterior synechiae to the manufacturer's trademark on the surface of a Shearing intraocular lens were noted ten days after the implantation of the lens.,0
"Therefore, thorough investigation with an ultrasound-guided aspiration followed by an early drainage of the collection is warranted and mandatory.",0
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.,1
Combined thrombolytic therapy for prosthetic mitral valve thrombosis.,0
We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.,1
We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD).,1
A 24-year-old woman with type 1 neurofibromatosis receiving long-term baclofen therapy was admitted with presumed pneumonia which was successfully treated with antibiotics.,0
"After adequate hydration and administration of oral colchicines, the patient's right knee pain subsided and the uric acid serum level returned to normal.",0
A computerised tomography scan and a magnetic resonance imaging excluded a central lesion.,0
Metronidazole neuropathy.,1
"A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.",1
"Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.",1
Here we report ramipril-induced cutaneous vasculitis in a patient who required steroid therapy to control it.,1
"The nasal challenge test with a calcitonin nasal spray, up to 150 UI, was negative.",0
Recombinant Factor VIIa (FVIIa) can be used to reverse coagulopathy in patients on coumadin who sustain a traumatic injury.,0
A magnetic resonance imaging (MRI) scan showed a large mass arising from the posterolateral aspect that was 90% extracranial and 10% intracranial on the right side of the skull.,0
We describe six patients who developed tardive dyskinesia after treatment with sulpiride for depression or gastrointestinal symptoms.,1
Nitrofurantoin-induced pulmonary toxicity during pregnancy: a report of a case and review of the literature.,1
"We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).",1
Herpetic tracheobronchitis may be a commoner clinical syndrome than generally assumed.,0
On-going monitoring of alteplase-treated patients may allow the opportunity to perform rescue intra-arterial therapy.,0
We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.,1
"CONCLUSIONS: Prolonged exposure to itraconazole, administered either continuously or intermittently, may precipitate severe and irreversible hepatotoxic events.",1
Two of the patients (1 and 3) are from a multicentre trial of adjuvant chemotherapy for gastric carcinoma.,0
Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.,1
We describe such a case who responded to chemotherapy and not to low doses of corticosteroids.,0
"The patient had been receiving factor VIII:C clotting factor concentrates (mean 60,000 U/year) since 1975.",0
"The conditions treated were: Hodgkin's disease (four patients), primary amyloidosis, primary macroglobulinemia, malignant lymphoma, multiple myeloma, and carcinoma of the tonsil.",0
They should be recognized as a possible side effect of GBP treatment in adults.,0
A 55-year-old male patient with hepatitis B-related liver cirrhosis was found to have advanced hepatocellular carcinoma.,0
"A 3-year-old boy developed alopecia areata (AA) universalis in the convalescent status of phenobarbital-induced AHS, compatible to the evidences of increased lymphocyte proliferation and increased dead cells percentages while his peripheral blood mononuclear cells were incubated with phenobarbital.",0
"In addition, known and/or possible mechanisms of the disorders are discussed.",0
"Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).",1
"Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).",1
Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.,1
She had been receiving oral quinine intermittently for muscle cramps.,0
"Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.",1
"Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.",1
The purpose of this article is to present the first case-series of posterior reversible encephalopathy syndrome (PRES) associated with L-asparaginase treatment.,1
RESULTS: The patient presented with recent-onset delusional ideation associated with cognitive decline.,0
After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia.,1
"Cell-mediated immune reactions mediated by OKT8+T cells might have caused the leukopenia, although other mechanisms involving cytotoxic antibodies or antibody-dependent cell-mediated cytotoxicity cannot be excluded.",0
"Therefore, clinicians should pay close attention to possible onset of RD in patients with multiple risk factors for TD, even when SDA therapy is used.",1
PURPOSE: To report a case of traumatic flap dehiscence and Enterobacter keratitis 34 months after LASIK.,1
We have used anti-angiogenetic therapy with thalidomide in two AILD patients and observed remarkable responses.,0
"Reports in the literature of isolated agranulocytosis are few, although they may be associated with significant morbidity and mortality.",0
Pulmonary thromboembolism following total laryngectomy and neck dissection: a case report.,0
"Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.",1
We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU.,1
Full recovery to pre-episode status of a quiet eye with clear vitreous was seen in all patients.,0
An organic mental syndrome developed in a patient soon after he underwent repair of a dissecting thoracic aortic aneurysm.,0
"The daily VPA dose was increased to 1500 mg, and olanzapine was introduced.",0
"With initiation of treatment, her pulmonary symptoms and radiographic and spirometric evidence of BO resolved.",0
Selective arterial catheter angiography showed an acute occlusion of the posterior tibial artery.,0
"As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.",1
RESULTS: The patients in our series improved significantly when the serotonin antagonist cyproheptadine was added to their regimens.,0
In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.,1
"In the oncology patient, chemotherapy, corticosteroids and bone marrow transplantation (with associated preparation therapy) have all been implicated as possible causes.",0
Inhibitory effects of various drugs on dual asthmatic responses in wheat flour-sensitive subjects.,0
Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.,1
"BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.",1
"A 23-year-old black woman with a two-month history of seizure disorder was admitted to a hospital with nausea, vomiting, fever, lymphadenopathy, diffuse maculopapular rash, left-upper-quadrant tenderness, and hepatomegaly.",0
We present the case of a 75-year-old man with ankylosing spondylitis who developed surgically induced necrotizing scleritis (SINS) more than 3 years after uneventful extracapsular cataract extraction and posterior chamber intraocular lens implantation.,0
"A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.",1
OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.,1
The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.,1
Pathognomonic signs of CIN were present.,0
"The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few particular cases of NE, e.g., perforation of the bowels, a surgical intervention is necessary.",0
Skin biopsy revealed multiple superficial thrombosed vessels with focal epidermal necrosis as well as prominent interstitial mucinosis.,0
"OBJECTIVES: A 56-year-old man developed an erythematous, circle-shaped lesion on his penis.",0
Flap salvage is often successful if vascular complications are recognized and treated early.,0
CASE SUMMARY: A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma was switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po for better hypertension control.,0
Blood chemistries revealed severely depleted sodium and potassium concentrations from a normal baseline within a 7-day period.,0
"Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.",1
"Based on these findings, the patient was diagnosed with DRESS/DIHS caused by zonisamide.",0
BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.,1
Appropriate stains indicated that this had many characteristics of lipofuscin.,0
"The observation of responses in 3 patients with T315I phenotype-refractory CML or Ph-positive ALL, at doses of MK-0457 associated with no significant extramedullary toxicity, is very encouraging.",0
"After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.",1
"A 69-year-old woman developed Cushing's syndrome after long-term use of Sinatren, an Indonesian over the-counter drug, which was pharmacologically analysed three times before the correct content was discovered.",0
"Although the two local anesthetics usually do not cause methemoglobinemia, we suspect that the displacement of lidocaine from protein binding by bupivacaine, in combination with metabolic acidosis and treatment with other oxidants, was the reason for the development of methemoglobinemia.",1
A 32-year-old male schizophrenic patient on ziprasidone treatment was admitted to the hospital following a seizure.,0
This was treated immediately with oral acyclovir.,0
"The nature of the process was not recognized initially, and the patient was treated with intravenous antibiotics.",0
Liver abscess caused by an infected ventriculoperitoneal shunt.,0
"We propose diagnostic criteria for this under-recognized new clinical syndrome, and recommend that physicians routinely measure serum gastrin levels in persistent cases of PPI-dependent dyspepsia unassociated with H. pylori.",0
The boy is now 14 months off tuberculostatic treatment and 8 months off AML therapy.,0
"Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.",1
Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.,1
"With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.",1
"Administration of low-dose cidofovir was associated with clearance of BK virus DNA from blood and allograft, and stabilization of renal function in both patients, without significant toxicity.",0
"Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon.",1
Hypokalemia after normal doses of neubulized albuterol (salbutamol).,1
"Nonsteroidal antiinflammatory agents (NSAIDs), especially naproxen and other propionic acid derivatives, appear to be the most common offenders.",0
"In patients with GI GVHD clinicians need to be aware of the potential for oral absorption and, in select cases, monitoring of levels may be appropriate.",0
"With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking.",1
"During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.",1
The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.,1
CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.,1
Coexistence of hereditary angioedema and Turner's syndrome.,0
"Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses resulted in mild, transient neurological symptoms (paresthesias) in only one of 30 patients so treated.",1
We report a series of three patients who whilst using topical facial steroids developed advanced glaucoma.,0
"Aspergillus sp. infection was the most common of all CNS infections followed by viral, bacterial and protozoal.",0
"His renal function returned to baseline 14 days later with supportive care, folinic acid rescue, and urinary alkalinization.",0
"CONCLUSION: The increasing role of radiotherapy in nasopharyngeal carcinoma treatment, together with improved patient survival, is likely to lead to radiation-induced, secondary, space-occupying lesions being encountered more frequently.",0
It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.,1
We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ).,1
In this case senna was likely the cause of a subacute cholestatic hepatitis exemplifying again the potential role of herbal related liver injury.,1
Combined ketoconazole and amphotericin B treatment of acute disseminated histoplasmosis in a renal allograft recipient.,0
PURPOSE: Topiramate-induced angle-closure glaucoma (TiACG) is believed to be related to its sulfonamide moiety.,1
"We report a 28-year-old woman of normal intellect, who had three late-onset seizures with unusual ictal features and secondary generalization during prolonged and vigorous tooth brushing.",0
Probable early acute hepatitis with parenteral amiodarone.,1
A 14-year-old boy with chronic granulomatous disease and severe infection was admitted to the hospital because of left shoulder aspergillus' infection and pain.,0
Atypical antipsychotic induced hypothermia is a rare adverse effect that may present with mild to severe symptoms.,0
"We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin.",1
Three Alzheimer's disease patients with Pisa syndrome were presented.,0
We report five cases of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) that were probably associated with olanzapine.,1
Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).,1
Early clinical suspicion and availability of CT or magnetic resonance imaging for prompt diagnosis are essential to initiate appropriate medical therapy and timely surgery.,0
"The progressive appearance of squamous epitheliomas and other cutaneous adverse events, such as the ulcer, suggests that alternative chemotherapies should be considered for the treatment of myeloproliferative diseases.",0
The methimazole was stopped and treatment with subcutaneous granulocyte colony-stimulating factor (G-CSF) was initiated.,0
"These measurements (720 before and 832 on therapy) suggested that both early and late dumping symptoms are causally related to the rate of glucose elevation and decline, rather than to glucose peak and nadir, respectively.",0
Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.,1
"In addition, she required additive reductions of 33-42% in her weekly warfarin dose with each chemotherapy cycle to maintain a therapeutic INR (goal range 2.0-3.0).",0
"FK506, which began to be administered 12 days earlier, rose to a level of 44 ng/mL (normal range, 10-20 ng/mL) 1 day before neurologic abnormalities began.",1
A 67-year-old man was admitted for management of a diabetic foot ulcer.,0
One patient had severe temporary weakness after an ampicillin sodium challenge.,1
"Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with ""familial seizure disorders"" may in fact have the long QT interval syndrome.",1
Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.,1
Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy.,1
"That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).",1
Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.,1
"Ticlopidine is an oral antiplatelet agent frequently utilized in the treatment of cerebrovascular disease and is rarely associated with severe bone marrow suppression, typically aplastic anemia.",1
Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia.,1
"ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.",1
"After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.",1
"Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies.",1
"Histologically, we diagnosed this case as having pre-cirrhotic nonalcoholic steatohepatitis (NASH).",0
Severe hyperphosphatemia following acute tumor lysis syndrome.,0
Cimetidine is a rare cause of drug-induced fever.,1
Two episodes were incident cases (no prior IBD); one episode was recurrent colitis or a nonincident case (flare of prior IBD).,0
CONCLUSIONS: Clinicians treating elderly patients with olanzapine should be aware of the potential for rapidly developing hyperglycemia and monitor such patients accordingly.,1
"The patient was a 24-years-old male referred to the OPD Clinic at Zare Psychiatry Hospital in 2007 with symptoms of delusion of control, delusion of persecution, delusion of somatic and auditory hallucination, for the last year.",0
Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma.,1
Endoscopy demonstrated dimpling of the gastric mucosa on the anterior wall of the stomach.,0
"Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).",1
"However, acute cardiomyopathy and pericarditis secondary to methylphenidate use has been rarely reported.",1
"Although these hormone therapies are generally considered benign, we describe 3 cases of acute cardiac rejection temporally associated with the use of these drugs in men who have undergone cardiac transplantation.",0
The present authors report the case of an adult with chronic granulomatous disease who developed an unusual lung fibrosis associated with severe pulmonary hypertension.,0
Serum glutathione levels were assessed in a patient with genetically proven Unverricht-Lundborg disease (ULD) before and during treatment with the antioxidant N-acetylcysteine (NAC).,0
"In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.",1
Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report.,1
Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.,1
RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.,1
CD-20 expression in post-transplant lymphoproliferative disorders: treatment with rituximab.,0
Actinomycosis of the female genital tract has greatly increased over the last two decades.,0
In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.,1
AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.,1
These arrhythmias were resistant to standard antiarrhythmic therapy.,0
This case shows the difficulties in the diagnosis of CD20-negative lymphomas when the number of tumor cells is low and when they are found in a predominant T-cell context.,0
"The patient developed classic signs of TLS within 24 h of chemotherapy, including acute renal failure.",0
"Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.",1
"""Broken heart syndrome"" after separation (from OxyContin).",0
"Staphylococcus species, Streptococcus species, and less commonly, gram-negative rods comprise the majority of isolated organisms.",0
"In conclusion, the in vitro susceptibility assay as well as nucleotide sequence of clinical isolate is important to choose appropriate antiviral agents for patients who have persistent CMV reactivation after stem cell transplantation.",0
In such patients the drug is withdrawn and replaced by another medication.,0
A 55-year-old woman received 2 cycles of therapy with cisplatin 100 mg/m2 without difficulty.,0
"We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.",1
"Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.",1
"Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.",1
We describe a patient with metastatic prostate cancer who developed nonoliguric renal failure during treatment with suramin.,1
"Tumor resection was performed, with posterolateral fusion and spinal instrumentation.",0
We report three cases of amiodarone-induced torsades de pointe.,1
Occult quinine-induced thrombocytopenia.,1
"In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.",1
We present a case of successful stenting of the left main coronary artery (LMCA) in a patient with ACAD.,0
"Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.",1
De novo absence status of late onset following withdrawal of lorazepam: a case report.,1
CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.,1
We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.,1
"When additional indicators of treatment outcome are considered, such as cognitive and occupational and social functioning, it is clear that the overall outcome for schizophrenia is far from satisfactory.",0
"We present the cases of two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) who developed inflammatory musculoskeletal manifestations, following IFN-beta therapy.",1
"Laboratory determinations were used to directly evaluate therapeutic anticoagulant effects, and dosage regimens were adjusted to achieve desired anticoagulant levels.",0
A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.,1
This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.,1
Hepatopathy subsided after the cessation of carbamazepine and lynestrenol.,1
Acute renal failure (ARF) is a rare but severe complication of active idiopathic nephrotic syndrome (INS) in children.,0
Cerebral dysfunction predated the development of minimal diabetic complications and had been apparent for between 1 and 17 years.,0
We review the existing literature on AHS pathogenesis and illustrate a case complicated by liver dysfunction where the use of N-acetylcysteine (N-AC) and intravenous immunoglobulin (IVIG) may have altered the course of the disease.,0
"Most often, it is tolerated well.",0
Erythromycin is a macrolide antibiotic that may increase the risk of lovastatin-induced rhabdomyolysis.,1
Ifosfamide-induced nonconvulsive status epilepticus.,1
"We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril.",1
The delayed encephalopathy developed 9 and 22 months respectively after the first dose of intrathecal methotrexate.,1
Organic affective psychosis associated with the routine use of non-prescription cold preparations.,0
We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.,1
Thrombolytic therapy with tissue plasminogen activator (tPA) for acute myocardial infarction may result in major bleeding complications such as gastrointestinal or intracranial bleeding.,1
Positive inotropic support is routinely used for weaning from cardiopulmonary bypass circulation in patients with reduced left ventricular function.,0
Gemcitabine-related radiation recall preferentially involves internal tissue and organs.,1
"Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.",1
Cimetidine-induced fever.,1
In this study a case of BP which was difficult to control with systemic steroids was successfully treated with mycophenolate mofetil as adjuvant therapy.,0
All of these have been able to reduce oral prednisone doses.,0
Intranasal desmopressin-induced hyponatremia.,1
"Despite intensive supportive measures and specific therapeutic attempts, all three patients eventually died of septic shock.",0
Coexistence of psoriasis and subacute cutaneous lupus erythematosus (SCLE) is unusual.,0
The discordant time course behaviour of hematocrit and blood pressure points to the importance of residual renal tissue for blood pressure to develop during erythropoietin therapy in the renoprival status.,0
"When clonazepam was reduced and discontinued, these behaviors significantly decreased from 3.1% of intervals (95% confidence band = 1.6% to 4.6%) to 0.1% of intervals (95% confidence band = 0% to 0.1%).",0
Hepatic artery aneurysm associated with upper gastrointestinal bleeding after intrahepatic artery chemotherapy.,0
"We suggest that sarcoidosis may develop in chronic hepatitis C patients during interferon alpha and/or ribavirin treatment, and diagnostic tests for this adverse effect should be performed during the follow-ups.",1
The present report describes four cases of this association in which tamoxifen had been administered to all of the patients.,0
"Five days after the fourth dose of vincristine, she presented with bilateral ptosis.",1
"Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.",1
This may also represent an alternative to ex-vivo expansion and deserves further investigation.,0
The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.,1
"Seven years after the transplantation, cholelithiasis, cholecystitis, cholangitis and subsequently secondary chronic biliary sclerosis were detected.",0
Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.,1
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
"A seven-year-old boy with acute lymphoblastic leukemia received vincristine sulphate 1 mg, 1 ml intramuscularly, into his glutea, inadvertently, in the local hospital.",0
"One year later, she experienced a fatal hepatitis B virus (HBV) reactivation.",0
"A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",1
Polymyositis after propylthiouracil treatment for hyperthyroidism.,1
"We present a case of typhlitis in a patient with advanced non-small cell lung cancer (NSCLC) who received pemetrexed, as second-line chemotherapy treatment.",0
The patient expired after seven cycles of treatment had been completed because of pulmonary fibrosis and the drug toxicity of bleomycin.,1
We report a case of secondary glaucoma caused by epithelial downgrowth in which filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil.,1
Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.,1
Plasma atenolol levels decreased from 7.4 mg/L to 2.1 mg/L although significant rebound occurred between dialyses.,0
We presented the case of a patient who developed a cutaneous reaction induced by captopril with positive patch test.,1
"Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.",1
The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.,1
"However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.",1
The diagnosis of lead toxicity is often delayed and abdominal pain is mistaken for acute abdomen.,0
Intravitreal triamcinolone may have had an influence on the exacerbation of retinochoroiditis in the posterior pole of the patient.,1
"He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.",1
Hypercalcemia has not been previously reported during treatment with topical tacalcitol.,0
Phenytoin and carbamazepine were necessary to control the seizures.,0
A case is reported of myoclonus induced by an antidepressant purported to have no effect on serotonin activity.,0
"Seizures occurred in two patients with probable Alzheimer's disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor.",1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
This report describes four patients with variant angina and one patient with rest angina who had coronary spasm that was refractory to sublingual or i.v. nitroglycerin.,0
This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.,1
BACKGROUND: Radiation recall pneumonitis describes a very rare reaction in a previously irradiated area of pulmonary tissue after application of pharmacological agents.,0
One of them had a high pressure gradient of the left ventricular outflow tract and the others had earlier onset.,0
"Manifestations of ocular blastomycosis can range from keratitis to panophthalmitis, and it is often difficult to diagnose ocular blastomycosis early.",0
Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.,1
"A 33 year old male Nigerian presented with widespread involvement of peripheral nerves, several of which were tender and painful.",0
These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.,1
Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.,1
"However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.",1
"Reactivation of herpes zoster in this case could have been coincidental, or secondary to LASIK and the subsequent use of topical corticosteroids following LASIK.",0
We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).,1
Thymic hyperplasia following successful chemotherapy.,0
"Patients receiving amifostine who develop only fever should be evaluated for an adverse drug reaction, as well as for sepsis and fevers of neutropenia, and it may be necessary to discontinue the drug.",1
When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.,1
A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-beta therapy against malignant melanoma.,1
"RESULTS:Haze, uncorrected visual acuity (UCVA), and BCVA improved in all patients.",0
We report a case of RTA secondary to FK506 administration in liver transplantation.,1
Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.,1
"The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.",1
We report the 1st case of R. equi brain abscess in a patient receiving corticosteroid monotherapy and review the literature for risk factors and sites of infection.,0
The prevention and treatment of de novo HBV infection after OLT is discussed.,0
"With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.",1
Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.,1
Jude total therapy studies XIII.,0
"To know the histochemical effects of steroid treatment on eosinophil accumulation in nasal polyps of AIA and the histochemical feature of a recurring polyp and to detect distributional differences between storage and secreted forms of eosinophil cationic proteins, we carried out immunocytochemical labelling with antibodies against EGI (recognizing resting and activated eosinophils) and EG2 (recognizing only activated eosinophils), and determined eosinophil infiltration in nasal polyps that were obtained before and after steroid treatment, and at recurrence of polyps.",0
A case of a female with advanced squamous carcinoma of the vagina is presented.,0
Shakuyaku-kanzo-to (SKT) is a traditional herbal medicine that is widely used for muscular cramp and abdominal pain.,0
A small initial dose of prazosin ranging from 0.5 to 1 mg has been recommended to avoid the first-dose phenomenon characterized by a sudden and severe drop in blood pressure after the administration of the first dose of prazosin.,1
PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.,1
Ultrastructurally the follicular cells contained large residual bodies composed of abundant electron-lucent lipid droplets of variable size.,0
"Our diagnosis was tuberculosis-related visual loss, which could be due to neuroretinitis, intraocular tuberculosis or chiasmal tuberculoma.",0
This case study presents a situation in which a loss-of-resistance technique resulted in an inadvertent discogram.,0
"This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.",1
"Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.",1
Clonal cytogenetic evolution was evident in 2 of the 3 patients and included an extra Philadelphia chromosome in both.,0
Acute abdomen due to endometriosis in a premenopausal woman taking tamoxifen.,1
We have observed an increasing number of autopsies on patients with chemotherapy-related complications.,0
"The administration of ""sweet spirits of nitre"" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.",1
"He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.",1
"We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.",1
This was suggestive of type I hypersensitivity reaction.,0
"Toxicities included fever, skin rash, somnolence and a generalized seizure.",0
"After other potential causes of liver toxicity were excluded, TMP-SMX was determined to be the cause of his acute liver toxicity.",1
Administration of hydrocortisone reversed the mental status changes seen in this patient.,0
Listeria monocytogenes peritonitis in a patient on continuous ambulatory peritoneal dialysis.,0
The cause of the intracranial disease was attributable to the retrograde cerebral venous congestion.,0
"This case, which afforded a unique opportunity to follow the consequences of weakening scapular stabilizers over time, provides evidence for the etiologic role of scapular dyskinesis in SIS and shows that SIS is a potential complication of botulinum therapy for myofascial pain involving the scapular stabilizers.",0
We report a case of an infected subgaleal hematoma caused by an unusual micro-organism in a previously healthy 11-month-old girl.,0
"From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).",1
The right time to perform surgery is hard to define.,0
"However, we report the case of an 88-year-old woman who was treated for prosthetic joint infection and methicillin-resistant Staphylococcus aureus bacteremia with vancomycin followed by linezolid therapy.",0
"He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.",1
"The major contraindication to the use of intravenous verapamil is recent administration of intravenous beta-blocking agents (i.e., within the past two hours).",0
Patients whose trigeminal branches have been subjected to repeated surgical procedures and who have relentless unilateral face-jaw pain should be classified as having chronic traumatic trigeminal neuralgia.,0
Osteonecrosis has been well-documented in the past.,0
Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.,1
"Three patients who had experienced neuroleptic-induced akathisia in the past reported that the symptoms of fluoxetine-induced akathisia were identical, although somewhat milder.",1
"However, recently we were confronted with two cases within 1 month.",0
"We should also bear in mind that BMD scores alone are not indicative of fracture risk, and other tools such as the WHO-FRAX (Fracture risk assessment tool), serum vitamin D3 levels and bone turnover markers should be used where appropriate.",0
The procedure offers patients the opportunity to avoid the risks and expense associated with surgical correction.,0
"BACKGROUND: Rapid graft dysfunction caused by hepatitis C virus (HCV) reinfection, although uncommon, is a disastrous complication in liver transplant patients.",0
We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.,1
"We report on a patient who underwent renal transplantation using Campath-1H induction and tacrolimus maintenance therapy who developed HUS, which was managed by plasma exchange and switch to Rapamycin.",0
"After the moxifloxacin was stopped, the corrected QT interval normalized and a permanent cardiac pacemaker was implanted.",0
Their parkinsonism improved on discontinuation of metoclopramide therapy.,1
"A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.",1
Isotretinoin teratogenicity.,1
"OBJECTIVE: To report a case of chronic, nonproductive cough secondary to the angiotensin-converting enzyme (ACE) inhibitor quinapril, with complete resolution after switching to another ACE inhibitor, fosinopril.",1
Case report.,0
Subsequent management with topical steroids was complicated as the patient was a steroid responder and developed a markedly raised intraocular pressure that was managed with a topical anti-glaucoma agent.,0
"She was treated with high dosage corticosteroids and incurred severe side effects, including bone marrow depression, renal magnesium stones, osteoporosis, depression of affect, convulsions with cerebral damage and adrenal suppression.",0
A 65-year-old man on warfarin therapy with a sudden spontaneous onset of sub-conjunctival haematoma associated with bloody tears was assessed in the clinic following a referral from an optometrist.,1
"This article describes the interval appearance of malignant, linear-branching, microcalcifications during neoadjuvant chemotherapy for locally advanced breast cancer.",0
"One must be cautious in extrapolating from a case report, but these findings strongly suggest a direct effect of carbamazepine on spermatic function.",0
This case also constitutes an experimental model.,0
"We present the case of a postictal patient with lethargy, hyperammonemia, otherwise normal liver function tests, and a therapeutic valproic acid level.",1
"Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.",1
Both patients had laboratory-proven subtherapeutic anticonvulsant serum levels.,0
"The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.",1
Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate.,1
"The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.",1
The patients were monitored at months 1 and 3.,0
"Here, we report a 73-year-old male hydrocephalic patient who had undergone uneventful V-P shunt surgery 9 years ago.",0
"Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.",1
Bone marrow biopsy showed a moderately hypocellular marrow; 51% of the nucleated cells were blasts with myelomonocytic differentiation.,0
"The infection ultimately cleared in all eyes with topical therapy using chlorhexidine, propamidine, and antibiotic ointment with neomycin.",0
"DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.",1
"No recurrence of clinical signs occurred during the follow-up period (1 and 4 years, respectively).",0
METHODS: We describe a patient with chronic hepatitis B viral infection and RA treated with etanercept.,0
Further studies on the precise association with different therapies are thus needed.,0
Objective responses were observed in both basal cell carcinoma (BCC) patients.,0
Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?,1
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
An unusual patient with post-transfusion purpura is described who had a rapidly rising platelet count with high dose steroid treatment in the presence of an increasing anti-PlA1 antibody titre.,0
DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.,1
Atrial fibrillation after vardenafil therapy.,1
The use of electroconvulsive therapy (ECT) in MG raises certain challenges.,0
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
"Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication after lung transplantation, for which several risk factors including pretransplant seronegativity for Epstein-Barr virus are known.",0
"Patient 1 developed squamous cell carcinoma of the skin with recurrence, and Patient 2 developed anaplastic carcinoma of the urinary bladder.",0
Doses of 0.8-1.0 mg/kg of L-AmpB were administered intravenously every 24-72 hr.,0
"New drugs have been introduced to manage the cardinal motor symptoms of PD, and other agents have been borrowed to treat the nonmotor manifestations of the illness.",0
"We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.",1
There are few reports in the literature related to sulfonylurea-induced hepatotoxicity.,0
"She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.",1
This is the first case in the literature--to the best of our knowledge--describing a minimally invasive strategy using CT fluoroscopic guidance to perform an injection of thrombin into the perfused pseudoaneurysm to seal a leakage.,0
"The diagnosis may be made more difficult due to lack of typical allergic symptoms, presence of other drugs, or confounding factors and equivocal noninvasive laboratory studies.",0
We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.,1
CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.,1
"Visceral leishmaniasis is rare among patients under immunosuppressive therapies, and even more among patients under anti-TNF-alpha treatment, where only four cases have been described.",0
"We further used immunohistochemistry (IHC) to examine the relative role of platelet-derived growth factor-B (PDGF-B), insulin-like growth factor I (IGF-I), transforming growth factor-beta1 (TGF-beta1) and cyclooxygenase-2 (COX-2) in the pathogenesis of BCNU-related pulmonary fibrosis.",1
Atenolol induced memory impairment: a case report.,1
School-based methylphenidate placebo protocols: methodological and practical issues.,0
"A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.",1
"Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome.",1
"Although corticosteroids are frequently used to prevent vomiting induced by chemotherapeutic agent, their mental effects have received little attention in oncology settings.",0
"In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.",1
Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.,1
PURPOSE: To investigate the concentration-side effect relationship in a patient with severe acyclovir-induced neurotoxicity and to summarize the information available in the literature about central nervous system side effects due to acyclovir.,1
"Recently, many cooperative groups use dexamethasone instead of prednisone during induction.",0
Neither our patient's clinical symptoms nor her serologic parameters improved possibly because of the low dosage and/or short duration of cyclosporine A treatment.,0
A 69-year-old female with chronic posterior uveitis was treated with cyclosporine while on concomitant oral simvastatin for hypercholesterolemia.,0
"Thirty days after the 2nd booster dose, several pruritic, polygonal, purple, papules appeared on the volar aspect of the patient's wrists.",0
Cultures of both the cerebrospinal fluid and aspirated liver abscess isolated MRSA.,0
We also discuss the apparent increased thrombotic risk in patients receiving a VAD for chemotherapy induced cardiomyopathy and the implications this may have for the choice of VAD.,0
Histological examination of liver biopsies showed diffuse microvesicular steatosis.,0
METHODS: A fully alert 83-year-old woman with disciform scar right eye (OD) and occult choroidal neovascularization (CNV) left eye (OS) experienced a progressive visual loss to 20/800 OD and 20/400 OS.,0
"CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.",1
We have cared for three children in whom four episodes of dystonia proceeding to opisthotonus occurred in association with carbamazepine use.,1
Henna is a traditional cosmetic agent and is used worldwide.,0
"Pericarditis and cardiac arrhythmias developed, but the patient did not have cardiac tamponade.",0
Discussion covers conjunctival carcinoma and behaviour of HIV-related tumours with antiretroviral therapy.,0
The clinical improvement and decreasing in muscle enzyme level occurred after colchicine withdrawal.,0
"Approximately 15 min after the first administration of nebulised morphine the patient became markedly bradypneic (respiratory rate: 4-5 bpm), hypotensive (BP 70/40 mmHg), and responded only partially to command.",1
Nasal septal perforation in a patient with allergic bronchopulmonary aspergillosis and rhinitis on long term corticosteroids.,0
Rasburicase for the management of tumor lysis syndrome in neonates.,0
An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.,1
Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades.,1
We present the case of a 20-year-old patient with Hodgkin's disease developing BOOP after chemotherapy (COPP/ABVD) and irradiation.,0
"A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.",1
Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).,1
Jaundice was the presenting symptom in all three.,0
"After the oily carcinostatic agents were administered by Lp-TAE, HT, at a temperature of greater than 42.5 degrees C, was induced for 40 min, twice a week by an RF of 8 MHz for a total of 10 to 38 times.",0
"Without other causes for the hyponatremia, she was diagnosed with the syndrome of inappropriate antidiuretic hormone, presumably caused by desmopressin.",1
We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.,1
"Instead, she referred an improvement with gonadotropin releasing hormone agonist (GnRH-a) for the treatment of endometriosis and then with tamoxifen as hormonal therapy after mastectomy and chemotherapy for breast cancer.",0
We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia.,1
This concerns 2 male patients who experienced incontinence while taking venlafaxine.,1
"Within 24 hours of fluid restriction and cessation of desmopressin, her symptoms and hyponatremia resolved.",1
Dermatomyositis is associated with malignancy in approximately 20-25% of cases.,0
OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.,1
PURPOSE: To report a new adverse effect related to treatment with bimatoprost.,0
Colchicine-induced rhabdomyolysis.,1
"To our knowledge, this is the first report of M. marinum occurring in a patient receiving infliximab.",0
Monitoring serum digoxin concentrations during digoxin immune Fab therapy.,0
CONCLUSIONS: Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipoatrophy.,1
"BACKGROUND: Most of the new fillers used for soft tissue augmentation in aesthetic dermatology are considered well tolerated, but very little data are available on their long-term tolerability, especially in patients receiving immunomodulatory therapy.",0
Each had angiographically documented bilateral high-grade stenosis or occlusion of the internal carotid arteries.,0
"Features of both de novo AML [FAB M2 morphology, t(8;21), and ""secondary leukemia"" (additional cytogenetic changes, resistance to chemotherapy) were present.",0
"Despite subsequent investigations, including analysis of urinary metabolites of organic and amino acids, measurement of serum carnitine and a muscle biopsy, we could not clarify the primary metabolic abnormalities in this girl.",0
Renal function gradually improved but nephrotic state was persistent.,0
"On admission, high levels of arterial hypertension were found.",0
We have cared for three children in whom four episodes of dystonia proceeding to opisthotonus occurred in association with carbamazepine use.,1
Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity.,1
Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine.,1
"We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.",1
"This paper reports on a 6.9-year-old autistic male who developed repeated episodes of acute dystonic reactions associated with pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration.",1
Etoposide is an important component of current HLH treatment regimes.,0
Detection of PVB19-DNA in serum with quantitative polymerase chain reaction (PCR) revealed a high level of viral load.,0
Fatal gemcitabine-induced pulmonary toxicity in metastatic   gallbladder adenocarcinoma.,1
"We identified NAT2*6/*7 in one patient, and NAT2*6/*5 in the other, suggesting that both were slow acetylator phenotypes.",0
INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).,1
"Its clinical manifestations include severe periarticular pain with inflammatory signs, especially in knees and ankles, causing functional disability.",0
"Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or ""cutting"" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.",1
"Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of tumor plugs to the vascular spaces; decrease in tumor tissue coherence secondary to chemotherapy may have further contributed to the formation of tumor emboli.",0
The case of a patient with infectious mononucleosis treated with cephalexin who later showed a rash is presented and the previous literature is reviewed.,1
The addition of catecholamines to local anesthetics should be considered.,0
Cerebral edema associated with Gliadel wafers: two case studies.,1
"As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.",1
"CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.",1
"Renal function returned to normal eventually, but she continued to have relapses of exfoliative dermatitis up to a year later.",0
"Two prior episodes of visual loss had occurred during oral contraceptive treatment, an association not heretofore reported.",0
Awareness of the condition is therefore of continuing importance.,0
"Finally, irinotecan therapy was initiated and led to dramatic clinical improvement.",0
"A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.",1
All three patients experienced remission of their disease at the time of the occurrence of marrow aplasia.,0
Recurrent septicemia with lethal outcome during and after cyclosporine therapy in severe ulcerative colitis.,1
Response of a promethazine-induced coma to flumazenil.,1
"Acarbose attenuated both postprandial glucose hyperglycemia and reactive hypoglycemia, which subsequently led to a significant reduction in dumping symptoms.",0
"This is an important pitfall because, when diagnosed early, bleeding in these patients is treatable.",0
The authors report a case of mania occurring in a woman in late life who had begun receiving hormone replacement therapy for osteoporosis.,0
"The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.",1
"Both patients were then treated with a carboplatin alternative to cisplatin in the following courses, which resulted in neither a relapse of the colitis nor a recurrence of the malignancies up to this time.",1
Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.,1
Polymyositis is a rare complication of interferon alpha treatment as a result of immune-modulating role of the drug itself.,1
Concentrated topical epinephrine is safe in endoscopic sinus surgery.,0
This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.,1
Acute Liver Failure Study Group.,0
Histological studies showed scattered perivascular infiltrates without vasculitis.,0
Other causes of the disease were ruled out.,0
It may also appear in complete remission after chemotherapy (chemotherapy-related).,0
"The administration of ""sweet spirits of nitre"" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.",1
"After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.",1
"We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.",1
Persistent hypoglycemia in a patient with diabetes taking etanercept for the treatment of psoriasis.,1
Possible interactions between the putatively hyperactive dopaminergic system and corticosteroids are discussed.,0
PET scintigraphy of etoposide-induced pulmonary toxicity.,1
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
Oral adverse effects due to the use of Nevirapine.,0
We present a case of steroid- and cyclophosphamide-resistant nephrotic syndrome complicated by disseminated strongyloidiasis which responded to anthelmintic agents.,0
"The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.",1
"His obstruction resolved, and he remains well at 11 months.",0
We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.,1
A case may be made for the discontinuation of the usage of chloral hydrate.,0
Administration of intravenous nitroglycerin in a patient with idiopathic pulmonary hypertension resulted in an increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance.,1
"During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.",1
The first patient displayed symptoms resembling those of organic brain syndrome which was not associated with a high serum lithium level.,0
"Is pseudo-Cushing's syndrome in a critically ill patient ""pseudo""? Hypothesis and supportive case report.",0
The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen.,1
Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).,1
He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.,1
"RESULTS: Despite high pretreatment values of serum alanine aminotransferase (ALT; peak value of 901 IU/L) and HCV-RNA (2.3 x 10(6) copies/ml), the combination therapy with IFN and ribavirin produced a rapid normalization of the serum ALT values, accompanied by the clearance of serum HCV-RNA.",0
We present a case of thrombosis of the right internal jugular vein presenting as a neck lump to the ENT department.,0
This case demonstrates the value of DWI in evaluation and diagnosis of sub-acute toxic leukoencephalopathy in patients being treated with methotrexate.,1
Diabetes Mellitus was observed in a patient given carbamazepine.,1
Bladder contracture: review for intravesical bacillus Calmette-Guerin complication.,0
The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.,1
Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF.,1
"When infection of the instrumented cage is diagnosed, emergency debridement with or without removal of implants, including the cage, appropriate wound closure, and the administration of potent antibiotics is the standard treatment.",0
Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.,1
We present a series of 9 MM patients who developed ONJ after treatment with bisphosphonates and chemotherapy.,0
Her body mass index (BMI) was 26.5.,0
"Given that discontinuation of nitrofurantoin and introduction of methylprednisolon therapy significantly lowered liver enzyme levels, restoring most of them to normal, we concluded that this was probably the case of toxic liver damage caused by nitrofurantoin.",1
[2] Anesthetized and intubated ferrets inhaled a placebo or VVR that was placed at the proximal end of the endotracheal tube.,0
"Macrolide antibiotics cause ototoxicity, which occurs most frequently when high serum concentrations are achieved.",0
We present a case of PG arising in the context of DA use for restless legs syndrome.,0
"In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis.",1
The persistent effects of methotrimeprazine meleate on various organs are typical of the prolonged biological action of the phenothiazine metabolites.,0
"METHODS: Skin prick test (SPT), nasal and intramuscular challenge test with commercial salmon calcitonin (Miacalcic) were performed.",0
"After treatment for five months on this therapy, he presented with new-onset atrial fibrillation.",0
"Even though AZ tends to strongly bind to plasma protein and its clearance is generally poor by hemodialysis (HD), in our patient, HD was observed to be rather effective since the clearance of AZ was 45.8 ml/min on HD and 66 ml/min on direct hemoperfusion (DHP).",0
"Of 371 patients treated with 8MOP, three (0.8%) developed an acute dermatitis in the PUVA-treated areas.",1
We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).,1
Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.,1
We describe a patient with phenobarbital-induced hypersensitivity syndrome who revealed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with limbic encephalitis during the course of the disease.,0
Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.,1
Cushing's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days.,1
"During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy.",1
A 23-year-old Caucasian man diagnosed with stage IVB Hodgkin's disease was referred to a university oncology section after completing 1.5 cycles of chemotherapy.,0
"Patients with a history of previous coronary artery disease or risk factors for coronary artery disease should be observed closely for signs of myocardial ischemia, particularly during the initial infusion.",0
"After stopping indapamide, glucose tolerance impairing may be reversed.",1
"In random trials of id injection, observation under clinical and laboratory conditions showed improvement in 63% (17/27) of the patients treated for 6 months with appropriate doses of di-Lex (III3FucnLc4), and in 72% (31/43) of those treated with an identical protocol for TCA.",0
Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection.,1
"Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.",1
"As suggested by the three clustered cases, this heretofore undescribed association between sudden unexpected cardiac death and thrombolytic therapy for AMI in patients with seropositive, corticosteroid-dependent RA suggests that further study and observation are needed.",0
"After 1 week of nefazodone therapy the patient experienced headache, confusion, and ""gray areas"" in her vision, without abnormal ophthalmologic findings.",1
This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.,1
"After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication.",1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
"Although weight gain often coincides with hyperglycemia in patients taking atypical antipsychotics, it does not seem to be a necessary causal factor.",0
Visceral herpesvirus infections in leukemic patients receiving cytarabine.,1
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
"Although the development of posterior subcapsular cataracts is a known complication of systemic steroid therapy, it usually occurs after several years of chronic administration.",0
Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).,1
The optimal diagnostic and therapeutic approach to this entity has not yet been clearly defined.,0
CT-scan disclosed right ethmoid sinusitis that spread to the orbit after surgery.,0
"After treatment with cimetidine, there was a rapid deterioration with decreased oxygen saturation and arterial PO2 values.",1
"We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.",1
Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use.,1
"In four eyes, the RPE tear developed after one PDT, in one eye the RPE tear developed after the second PDT, and in two eyes the RPE tear developed after the third PDT.",0
We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.,1
An angiogram showed a thrombus cranial to the screw.,0
"Autopsy revealed diffuse vasculitis involving the heart, lungs, kidneys, testes, spleen, liver, skin, gut wall and marrow with neuritis of gut wall nerves and ganglia.",0
Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus.,1
The occurrence of symptoms that could be ascribed to an acute coronary syndrome should always be taken seriously during the first rituximab infusion and investigated aggressively.,1
"In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.",1
This study underscores the risks of routinely administering protamine to susceptible individuals and the need for alternative therapies.,0
Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient.,1
"Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as ""red man syndrome"" and anaphylaxis.",1
"A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.",1
Two patients bled.,0
"METHOD: To address the gap in knowledge, we present 2 case reports of patients with early NMS-like symptoms.",0
Coenurosis is a zoonotic disease of humans caused by the larval stage of Taenia (Multiceps) species.,0
A minimum peripheral dose of 36 Gy HDR was administered in 12 fractions (twice a day) at 3 Gy per fraction for a period of 3 days.,0
Development and course of subjective and objective phenomena seem to be typical for patients in whom Ukrain could induce long-term complete remission.,0
"The patient was initially treated for presumed bacterial peritonitis but remained febrile and had persistent abdominal pain and peritoneal fluid pleocytosis, despite broad-spectrum antibiotic therapy.",0
Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.,1
BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.,1
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.,1
Tetracycline and benign intracranial hypertension: report of five cases.,0
"In addition, while cases of loop diuretic-induced pancreatitis, including furosemide, have been published, the allergic manifestations with both sulfonamide antibiotics and non-antibiotics in our patient suggest possible cross-reactivity between these 2 drug classes.",1
"Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs.",1
"Of note, change from tacrolimus to cyclosporine together with dexamethasone produced rapid response with status improvement.",0
"Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.",1
We report a protocol in which anticonvulsant agents are discontinued before discharge from our neonatal unit.,0
Lethargy in a newborn: lithium toxicity or lab error?,1
The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin.,1
"The harlequin color change is an unusual cutaneous phenomenon observed in newborn infants as transient, benign episodes of a sharply demarcated erythema on half of the infant, with simultaneous contralateral blanching.",0
Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.,1
Small bowel haemorrhage due to cytomegalovirus vasculitis.,0
"Despite this experience, the patient continued to deny that quinine was the cause of his problem and that he had failed in his obligations to advise the dentist of his drug history.",0
We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.,1
Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins.,1
"CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.",1
The difficulty in absorbing vitamin B12 when intrinsic factor is not available does not make oral replacement impossible; the dose just needs to be higher.,0
Chemotherapy-induced toxic leukoencephalopathy causes a wide range of symptoms: a series of four autopsies.,0
The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin.,1
Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation.,1
We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.,1
We believe that the acute renal failure in our patient was associated with anastrozole.,1
At dosages 22.5-30 mg/day (0.45-0.57 mg/kg/day) longstanding non-convulsive status epilepticus was noted in all three patients.,0
"This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.",1
No other cause of abdominal pain was identified.,0
Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.,1
"After a second course of hemodialysis the next day the patient's mental status improved, and she was discharged 5 d later.",0
Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports.,1
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
Several courses of oral voriconazole were required for resolution of the infection.,0
Inappropriate antidiuretic hormone following adenine arabinoside administration.,1
Delayed bowel injury is an infrequently observed complication of chromic phosphate administration.,1
Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.,1
"Intradiscal injection of triamcinolone hexacetonide for acute, subacute, and chronic sciatica.",0
The catheter in the pulmonary trunk was successfully removed through a percutaneous femoral vein approach using a pigtail catheter and goose neck snare.,0
Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.,1
"In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.",1
"Parkinsonism, pyramidal signs, polyneuropathy, and cognitive decline after long-term occupational solvent exposure.",0
A male patient with malignant lymphoma and thyroid papillary carcinoma after pediatric renal transplantation.,0
"Clinical examination revealed no evidence of vasculitis nor coagulopathy and initial neuroimaging (i.e., computed tomography, angiography, magnetic resonance imaging) demonstrated no features consistent with aneurysm, arteriovenous malformation (AVM), cavernoma, nor cerebral metastases.",0
"Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.",1
A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate.,1
Acute generalized exanthematous pustulosis induced by salazosulfapyridine in a patient with ulcerative colitis.,1
OBJECTIVE: To report a case of possible foscarnet-induced severe hypomagnesemia and other electrolyte disorders.,1
The procedure was carried out without fluoroscopic control and was complicated by a puncture of the thecal sack.,0
One of the postulated mechanisms of action is the release of endogenous opioids and/or the stimulation of opioid receptors in the central nervous system (CNS).,0
Patients stabilized on glyburide who are started on a fluoroquinolone should have their glucose levels monitored closely.,0
"After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.",1
He was initially managed as a suspected case of pulmonary embolism.,0
Motor milestones are slightly retarded--neurodevelopment is otherwise normal.,0
"Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.",1
"To our knowledge, this is the only reported case of tularemia occurring in the post-transplant setting.",0
Serum and salivary IgA were absent with high IgE serum total.,0
"After administration of Oxybutynin concomitantly with an increase in the dose of Dantrolene, she presented the clinical symptoms and laboratory finding of Carbamazepine intoxication.",1
"The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.",1
Angioimmunoblastic lymphadenopathy with dysproteinemia following doxycycline administration.,1
Herein we report four patients who underwent liver transplantation and developed neutropenia while receiving MMF.,1
His symptoms resolved within 2 weeks of discontinuing the isoniazid.,0
Cataracts induced by intermittent Decadron used as an antiemetic.,1
All other laboratory values were within normal range.,0
Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.,1
"A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.",1
"Despite infusion of hypertonic saline, his serum Na was not restored to normal.",0
One 13-year-old boy with life-threatening systemic disease experienced a partial remission of disease and tolerated a decrease in prednisone dose from 15 to 4 mg daily following 14 exchanges with FFP.,0
"Careful follow-up of so-called ""self-limited"" insulin edema is encouraged, and the early institution of diuretic therapy is advocated in elderly patients to prevent the development of overt cardiac failure.",1
"Patient examination 3 months after surgery revealed a large, central, full-thickness corneal infiltrate with multiple satellite lesions in the right eye.",0
Case report.,0
"CLINICAL PICTURE: A 60-year-old Indonesian male presented initially with fever, acute confusion and rapidly progressive right upper lobe pneumonia 3.5 months post-liver transplant, and was diagnosed with pulmonary tuberculosis by positive sputum smear for acid-fast bacilli and tuberculosis culture.",0
Cognitive and speech functions were specifically tested during the evaluation.,0
Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.,1
Recurrent endophthalmitis after cataract surgery with a scleral-tunnel incision.,0
Tremor: a newly described adverse event with long-term itraconazole therapy.,1
Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.,1
The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.,1
The obscure autopsy and neuroleptic malignant syndrome.,0
A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury.,1
Insulin-induced lipoatrophy in type I diabetes.,1
We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).,1
"Bisphosphonates in oral or intravenous forms are used to treat various diseases such as certain cancers, bone- and calcium-related disorders, osteoporosis, and osteopenia.",0
"CASE SUMMARY: A 45-year-old white man with a history of hypertension and gout was treated with losartan/hydrochlorothiazide, allopurinol, and colchicine.",0
"They both required treatment with insulin, one in very high dosage, but their insulin requirements fell progressively after the atypical antipsychotic was withdrawn.",0
"OBJECTIVE: Wernicke encephalopathy (WE) is an acute neurologic disorder characterized by a triad of ophthalmoplegia, ataxia, and mental confusion.",0
Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up.,1
"Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.",1
"In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.",1
"Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.",1
"That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).",1
It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.,1
"Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).",1
We also review other patients with paradoxical seizure exacerbation by benzodiazepines.,0
"We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.",1
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.,1
Ischaemic colitis in a patient taking meloxicam.,1
"On the seventh day of therapy, he experienced fever, with temperatures as high as 38.8 degrees C.",0
46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.,1
"Most symptoms resolved within several days, but tongue thrust continued until 6 months of age.",0
"CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.",1
Neuropathic pain syndrome as an occult manifestation of injury of the spinal cord after surgical repair of aortic coarctation.,0
We report the case of a 59-year-old man who was treated with intraarterial chemotherapy for metastatic colonic adenocarcinoma.,0
We report the case of a 20-year-old female with polyarteritis nodosa (PAN) who developed bilateral sensorineural hearing loss 25 minutes after receiving 30 mg of intravenous ketoralac.,1
Lamotrigine toxicity secondary to sertraline.,1
"As bilateral subthalamic nucleus (STN) stimulation produced improvement in his motor symptoms, his drug dosages were reduced postoperatively.",0
Animal studies suggest central D2-type dopamine receptor stimulation and oxytocin release from the paraventricular nucleus of the hypothalamus mediate the effect.,0
"PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.",1
"Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.",1
"To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature.",1
A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.,1
"The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.",1
The patient was a borderline candidate for mechanical ventilation for 3 weeks.,0
Cerebellar hemorrhage after multiple manual pumping tests of a ventriculoperitoneal shunt: a case report.,0
He had also developed elevated serum ammonia levels while on valproic acid.,1
The mechanism is probably multifactorial.,0
Pemphigus foliaceus induced by rifampicin.,1
"Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or ""cutting"" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.",1
"She was admitted following a fall and, after being given metoclopramide, developed movement disorder and a period of unresponsiveness.",1
"In addition, loading with one low oral dose of serine produced psychotic symptoms 5 h later which lasted 3-6 h.",1
Nineteen cases of unusual enhanced vincristine neurotoxicity related to itraconazole have been reported in children.,1
Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department.,1
"The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.",1
"During this period, urine losses of monovalent cation were only 55 mEq and body weight was constant at 48.2 kg.",0
We report the results of treatment with MACOP-B in 11 young patients with low grade lymphoma (LGL).,0
His immune system at this time was almost completely depleted.,0
Tardive seizure is a serious adverse reaction of electroconvulsive therapy (ECT).,0
"In addition, testosterone supplementation is frequently recommended for adult men with reduced libido or impotence and decreased serum levels of testosterone.",0
"The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.",1
Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.,1
OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).,1
"The drug acted through: (a) an already known inappropriate release of ADH, and (b) a hitherto unreported tubular lesion, which impaired the reabsorption of sodium and other coupled solutes.",0
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
The association between choroidal neovascularization (CNV) and retinal vein occlusive disease is uncommon.,0
METHODS: The patient underwent ocular examination.,0
Hydrofluoric acid burns.,0
A 52-year-old man with neither congenital heart disease nor history of drug abuse had a spiking fever after dental treatment and was diagnosed with pneumonia at a local clinic.,0
"2. The plasma cortisol level was significantly higher in the low-dose period (mean 13.90 +/- 3.35 micrograms/ml) than in the high-dose period (mean 9.06 +/- 2.75 micrograms/ml) although, paradoxically, the panic attack frequency was significantly lower in the low-dose period (mean 1.35 +/- 0.29/day) than in the high-dose period (mean 2.09 +/- 0.66/day).",0
The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on alpha-adrenergic receptors.,1
We report here on a heretofore undescribed respiratory syncytial virus (RSV) infection in a patient with a long-standing history of refractory CLL that was treated with fludarabine phosphate.,1
"In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.",1
We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.,1
We report a case and discuss its presentation and management.,0
"Laboratory tests revealed elevated serum creatine kinase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase.",0
A case is reported of a subphrenic abscess 12 months post-laparoscopic cholecystectomy in a 72-year-old male with identification of Actinomyces meyeri and the oropharyngeal commensal Klebsiella ozaenae.,0
"Despite percutaneous abscess drainage and antifungal therapy, general status deteriorated with persistent fever, severe pancytopenia and liver dysfunction.",0
"She was found to have high protamine-specific, as well as insulin-specific, IgE levels, and because of her poor response to regular insulin desensitization, she was desensitized to both regular and NPH insulin.",0
Seizures associated with fluoxetine therapy.,1
"This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.",1
"The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.",1
The most likely cause of such hyponatremic episode is vinblastine.,1
"This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.",1
The definitive role of antiviral therapy is yet to be clarified.,0
"The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented.",1
"The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.",1
Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.,1
"Although the symptom complex of disseminated cysticercosis has been well recognized for over half a century, it is not clearly included in recent disease classifications.",0
"Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.",1
"Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.",1
"A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.",1
"In addition, aggressive supportive measures to manage renal failure (hemodialysis) and labile hypertension, allowed this patient to have an extended survival as a result of successful therapy for this complication despite an underlying rapidly fatal malignancy.",0
"A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).",1
Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus sustained an anaphylactoid reaction after the intravenous administration of 50% solution of dextrose.,1
These findings are consistent with a model suggesting that both platelet and megakaryocyte mass contribute to a receptor-dependent consumption process regulating the endogenous TPO level.,0
"The precise role of testosterone in regulating mood, especially in alleviating depression, remains unclear although converging evidence indicates that androgens may exert antidepressant action.",0
She suffered from epigastric discomfort.,0
"Due to the potentially life-threatening complications of this condition and the increasing use of anticonvulsants in the treatment of mood disorders, psychiatrists must be aware of the diagnosis and treatment of this condition.",0
One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.,1
The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.,1
"Cat-scratch disease, primarily caused by Bartonella henselae, typically presents with regional adenopathy, and the role of antibiotics in the treatment is debatable.",0
"On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.",1
Ampicillin-associated seizures.,1
"Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.",1
Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.,1
"We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.",1
"Therefore, the possibility of an association by chance cannot be ruled out.",0
"The authors describe a 19-year-old girl with a history of recurrent late-onset, febrile cholangitis in whom persistent jaundice developed.",0
"A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.",1
Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.,1
"One year later, a progressive increase in policlonal gamma-globulin and a decrease in the CD4+ lymphocyte count to below 500/muL were detected in concomitance with ultrasonographic evidence of a progressive increase in the longitudinal diameters of the liver and spleen and signs of liver inhomogeneity.",0
Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.,1
"The fever abated promptly following discontinuation of acyclovir, and radiographic abnormalities resolved over ten days.",1
"The conditions may develop months or possibly years after cessation of intake of the drug and further cases may occur, although practolol has been withdrawn from use.",0
The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.,1
CONCLUSIONS: Bosentan may significantly decrease the anticoagulant properties of warfarin.,0
Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.,1
"RESULTS: High-contrast round bodies suggestive of Acanthamoeba cysts, as previously described, and irregular forms suggestive of Acanthamoeba trophozoites were found by tandem scanning confocal microscopy.",0
"Nevertheless, overdosage and intoxication are well documented.",0
"A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.",1
Psoriatic arthritis is an inflammatory arthritis associated with psoriasis.,0
Continuous EEG recordings showed a burst-suppression pattern with bursts containing only generalized spikes accompanying myoclonic activity.,0
"Eighteen patients were transfusion dependent; 10 had refractory anemia (RA), and 10 had refractory anemia with ringed sideroblasts (RARS).",0
"It is well known that exposure to manganese, solvents, or carbon monoxide in an occupational setting may lead to central nervous system damage and parkinsonism.",0
"Among CNS toxicities, generalized tonic-clonic seizures have been reported in both children and adults.",0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
Aspergillus terreus was isolated from her biliary fluid obtained at percutaneous transhepatic cholangiography.,0
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.,1
Premature closure of the ductus arteriosus: variable response among monozygotic twins after in utero exposure to indomethacin.,1
"Focal glomerulonephritis and interstitial nephritis in methicillin-treated, heroin-related infective endocarditis.",1
"A third case of acquired phosphate diabetes associated with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH), related to a pulmonary tuberculosis, is reported.",0
He received further chemotherapy without G-CSF and without any recurrence of the raised leucocyte count but failed to achieve full remission.,0
All patients had normal levels of thyroid-stimulating hormone and no other gastrointestinal complaints; evaluation revealed no other cause for the weight loss.,0
Parenteral-verapamil-induced sustained hypotension.,1
"Despite the administration of high doses of rhEPO, toxicity attributable to rhEPO was not observed in either the double-blind or open-label study.",0
Lower plasma levels of carbamazepine and valproate sodium were observed after 2 days of antineoplastic therapy.,0
Codeine intoxication in the neonate.,1
"Analysis of his cerebrospinal fluid showed a decrease in loosely-bound (catalytic) iron and increase in loosely-bound (catalytic) copper, total iron and products of lipid peroxidation, with values approaching normal as the symptoms resolved.",0
PURPOSE: To report a case of angiographically documented cystoid macula edema occurring after switching a pseudophakic patient from latanoprost to bimatoprost.,1
"Recent studies show that patients with other injury patterns do not appear to have significant differences post trauma, although the data about such outcomes is sparse.",0
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
"In the two cases, a combination of iloprost, a stable prostacyclin analogue (1 to 2 ng/kg/mn) with aspirin and dipyridamole was shown to inhibit ex vivo the heparin-induced platelet aggregation.",0
Red blood cell anemia in a patient with pemphigus vulgaris induced by the use of mycophenolate mofetil and prednisone.,1
"It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.",1
"In this paper, the authors present a case in which the current American Society for Regional Anesthesia and Pain Medicine guidelines were strictly followed with respect to withholding and reintroducing warfarin and enoxaparin after an epidural steroid injection, but the patient nevertheless developed a spinal epidural hematoma requiring emergency surgical evacuation.",0
"CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.",1
"The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.",1
"The dose was subsequently increased to 200 and 400 mg/day on alternate days, six days per week, and two months later AVT occurred.",0
"We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.",1
Association of fluoxetine and return of sexual potency in three elderly men.,0
Posterior reversible encephalopathy syndrome associated with methotrexate neurotoxicity: conventional magnetic resonance and diffusion-weighted imaging findings.,1
"However, the possibility of cancer-associated MAHA could not be excluded.",0
"The viral DNA copy number in whole blood remained positive, however, but was reduced.",0
The infants were treated with oral propranolol.,0
A case report.,0
It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.,1
Central nervous system toxicity associated with meperidine use in hepatic disease.,1
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
BACKGROUND: Several genetic polymorphisms increase the risk for venous thrombembolism (VTE).,0
"When high dose leucovorin was not used, residual neurological damage is not unusual.",0
"Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as ""retinoic acid syndrome."" This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.",1
The pharmacokinetics of oral 6-mercaptopurine (6MP) was assessed in 20 children with acute lymphoblastic leukemia during maintenance therapy.,0
Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor.,1
Severe autologous GVHD after hematopoietic progenitor cell transplantation for multiple myeloma.,0
Combined therapy of advanced prostatic carcinoma with estramustine and prednimustine.,0
Prospective randomized combination trials similar to the Intergroup Rhabdomyosarcoma Study in the pediatric population are necessary to better understand and manage these potentially curable sarcomas.,0
"OBJECTIVE: The aim of this report was to highlight the fact that hearing loss in thalassaemia patients can be related to marrow expansion affecting the ossicles, resulting in a conductive loss.",0
METHOD: The case histories of two geriatric patients treated with bupropion for major depression are presented.,0
"Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.",1
QPR/DPR and voriconazole are considered effective for patients with life-threatening opportunistic pulmonary infections who have previously been treated with intensive regimens including radiotherapies to the lung.,0
"The granular layer was preserved and, in some areas, hypergranulosis was found (Fig.",0
Ampicillin increased the preexisting electrical decrement in three rabbits with experimental autoimmune myasthenia gravis while the drug had no deleterious effects in less affected or normal animals.,1
The histological study of the duodenal biopsies showed villus atrophy.,0
"By the findings of Grocott stain on bronchoalveolar lavage fluid obtained on day 14, he was diagnosed as having PCP.",0
Severe chronic active Epstein-Barr virus infection mimicking steroid-dependent inflammatory bowel disease.,0
We consider that the MAHA in this patient is chemotherapy-related.,0
The TC occurred in the absence of hyperparathyroidism or a high calcium x phosphate product as evidenced by hormonal and biochemical examination as well as by a bone biopsy specimen that revealed an adynamic bone disease with significant aluminum staining.,0
Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.,1
"It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called ""3-week sulphasalazine syndrome"", a rare, but often fatal, immunoallergic reaction to sulphasalazine.",1
"Liver disease was diagnosed 12 +/- 4 years (range, 8-18) after initiation of antiretroviral therapy (ART).",0
"This case report confirms highly efficient inhibition of alcohol dehydrogenase by fomepizole, as well as demonstrate the safety of fomepizole in a patient already exhibiting end-organ retinal toxicity.",0
"Although interferon gamma has been implicated in the pathogenesis of sarcoidosis, only a few cases of sarcoidosis associated with interferon alpha therapy have been reported.",1
OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.,1
"Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning.",1
"We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis.",1
A retrospective review of 4405 patients' charts identified 214 patients who initiated antimalarial therapy between January 1987 and April 1993 for different rheumatic disorders (mean duration of therapy of 17 months).,0
"In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.",1
Danazol induced thrombocytopenia.,1
"Occasionally, traditional analgesic medication regimens cannot be used or are ineffective in relieving the pain.",0
The Naranjo probability scale suggests a highly probable relationship between AIN and pantoprazole therapy in this patient.,1
Power spectrum analysis studies revealed that heart rate had significantly improved and that power spectrum cardiovascular parameters had returned to normal.,0
Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity.,1
"The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.",1
"We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.",1
Celiac disease onset after pegylated interferon and ribavirin treatment of chronic hepatitis C.,1
This cause of bleeding could not be brought under control endoscopically.,0
Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?,1
Computed tomography guided core needle biopsy diagnosis of pelvic actinomycosis.,0
Eight of the 10 eyes were receiving topical steroids at the time of presentation.,0
"Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.",1
Abuse of salbutamol inhalers in young people.,0
The diabetes improved when the treatment was discontinued and worsened on re-introduction.,0
The diagnosis of disseminated Zygomycosis was made four days after onset of clinical symptoms.,0
"This condition can manifest as fever, myalgia, arthralgia, and Sweet syndrome, accompanied by distinct magnetic resonance findings involving the lower extremity musculature.",0
Ileus after administration of cold remedy in an elderly diabetic patient treated with acarbose.,0
We present the first case of ovarian endometrioid carcinoma and endometriosis in a postmenopausal patient who was treated with tamoxifen for breast cancer.,1
"Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.",1
The patient was admitted to the hospital and treated for SIADH.,0
A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented.,1
The clinical symptoms of gastric mucosa foveolar hyperplasia due to long-term PGE1 therapy simulate hypertrophic pyloric stenosis.,1
"In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.",1
"Aggressive chemotherapy, organ-preserving surgery, and high-dose-rate remote brachytherapy in the treatment of rhabdomyosarcoma in infants and young children.",0
"A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.",1
"A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.",1
"In this case report, we describe a child with biliary atresia who underwent a living LDLT and developed severe coagulopathy after reperfusion of the graft.",0
Pulmonary fibrosis is a severe complication associated with bis-chloronitrosourea (BCNU) therapy.,1
His wound cultures continued to be negative.,0
"Their decreases in VAS scores were 86.5%, 85.7%, and 77.6%.",0
We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.,1
"This case raises important questions about non-ketotic, hyperosmolar diabetic coma with antipsychotics, the possible association between hyperglycaemia and hyperthermia, and the direction of causality in this, the recognition of either syndrome when they co-exist and management issues in such patients.",0
"Fever recurred 30 days after his initial presentation, and blood smear-positive vivax malaria was diagnosed.",0
Five patients underwent botulinum toxin injection into the insertion of the levator and tensor veli palatini muscles.,0
"The process is classified as a nonvasculitic pustular bacterid, and as a prototype for antigen localization of lesions to the occluded epidermal sweat duct unit.",0
"Sodium phenylbutyrate was added to treatment with HU in two patients, but failed to produce an increase in total Hb despite increasing Hb F levels.",1
"We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.",1
"Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNalpha therapy for CML.",1
Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.,1
A successful clinical outcome was achieved upon recognition of the fungal pathogen.,0
"Levamisole was administered for 5 weeks (total dose, 1,500 mg).",0
"Central nervous system effects that parallel amnesia have been reported in 10-15% of the patients, including dizziness, ataxia, drowsiness, fatigue, confusion, and paranoia.",0
An objective causality assessment by use of the Naranjo probability scale revealed that NCSE due to ifosfamide was probable.,1
"Our report points out differences between acute, postacute, and longterm rehabilitation, describes the mobilization of patients in acute rheumatology units, and defines specific problems encountered in acute hospital-based rehabilitation of rheumatological patients.",0
We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.,1
Naloxone administration reversed the symptoms.,0
"The sensory overload is treatable with oral potassium gluconate, with onset of the therapeutic effect in approximately 20 minutes.",0
Wolff Parkinson White (WPW) syndrome: what the critical care nurse needs to consider when administering antiarrhythmics.,0
It is likely that RA contributed to the deterioration in renal function in these patients.,1
"Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux.",1
"Over 20 years, 877 patients with Crohn's disease, 492 women (56.1%) and 385 men (43.9%), were evaluated with patient follow-up data available for a mean of 7.8 years.",0
"The characteristics of the small subgroup of chronic anorexics, in whom the risk/benefit ratio may justify such a regime, are tentatively outlined.",0
A brief literature review is provided to assist in explaining the mechanisms by which clinically significant cerebral edema may develop.,0
"Salicylate intoxication was excluded, and theophylline was finally incriminated.",1
"In the previous four patients treated with cidofovir the outcome was discouraging, as was the case in this patient.",0
"A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",1
"She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.",1
The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.,1
"We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.",1
"This usually occurs in patients taking other ototoxic medications, with poor renal function, or with autoimmune disease.",0
"Laboratory tests revealed cyclosporine nephrotoxicity, cytomegalovirus infection, and prediabetes.",0
Recurrent portopulmonary hypertension after liver transplantation: management with epoprostenol and resolution after retransplantation.,0
"In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.",1
"In addition to the therapeutic benefits, prospective monitoring of free SDC in two of the patients also may have resulted in cost savings secondary to reduced hospital stay or less use of Fab.",0
A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.,1
Evidence-based mental health use of anticonvulsants during pregnancy.,0
"Future prospective controlled trials are needed to determine the efficacy, safety, tolerability, and possibly the optimal dose and timing of rFVIIa administration.",0
The present report examines the case of a patient with longstanding Crohn's disease who had never been treated with corticosteroids and who developed osteonecrosis of the talus.,0
Recognition of this rare entity will help clinicians avoid aggressive investigative and treatment modalities that can affect the results of PRK.,0
The literature review revealed that many cases typically present with chronic cough with or without dyspnea.,0
"Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.",1
Aggressive combination chemotherapy was required to reverse progressive thrombocytopenia and pulmonary involvement.,0
We encountered 2 patients with a psychiatric disorder (depression in one and catatonia in one) accompanied by motor inhibition that was complicated by pulmonary embolism (PE).,0
"Treatment included induction chemotherapy in preparation for a bone marrow transplant, which resulted in the disappearance of the cutaneous lesions.",0
Record et al. have recommended oral loading in selected patients.,0
FINDINGS: Histological examination of two cases revealed meningothelial meningioma.,0
"To our knowledge, four cases of interstitial pneumonitis associated with fludarabine have been reported in medical literature.",1
"Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.",1
"Toxicity occurred more frequently in those who received IM, and therefore high-dose, reserpine.",0
There have been several reported cases of omeprazole-induced AIN.,1
"After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.",1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
"The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.",1
The patient had previously reacted similarly to ampicillin infusion.,0
The cause of hiccups should be expressly stated for treatment.,0
A noninvasive method in the differential diagnosis of vecuronium-induced and magnesium-induced protracted neuromuscular block in a severely preeclamptic patient.,1
Carbamazepine-induced tics.,1
This case report describes a patient who developed a seizure with single-pulse transcranial magnetic stimulation during motor threshold estimation.,0
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.,1
We report a case of stutter priapism successfully treated with an oral antiandrogen.,0
Stroke is an infrequent but recognized complication of heroin addiction.,1
"On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.",1
"Although case reports exist concerning the positive impact of lamotrigine addition on clozapine treatment in resistant schizophrenia, a review of the literature fails to document any evidence regarding a combination of the two in the treatment of patients with schizophrenia and comorbid alcohol dependence.",0
Ciprofloxacin-induced hemorrhagic vasculitis.,1
Many new serotonergic antidepressants have been introduced over the past decade.,0
A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.,1
Squamous-cell carcinoma arising in a basal-cell epithelioma treated with 5-fluorouracil.,1
Investigations showed peripheral blood eosinophilia with thoracocentesis revealing eosinophilic exudative pleural effusion.,0
"Rofecoxib, used for dysmenorrhea, caused a herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand.",1
"Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis.",1
Scleritis complicating zoledronic acid infusion.,1
"After 2 months, visual acuity and ocular hyperemia returned to baseline levels.",0
This case illustrates the potential decoupling of PSA response from disease status in flutamide withdrawal.,1
"Fifteen patients with active disease and three whose disease was inactive received increased doses of corticosteroids, and four active cases and one inactive one stayed on the same doses.",0
"In four of the five patients, right-sided focal seizures were subsequently noted.",0
Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.,1
No relationship was identified between the extent and the severity of the skin lesions with the phenytoin and radiation dosages and with the histologic type and origin of the intracranial malignancy.,0
Postural epigastric pain as a sign of cytomegalovirus gastritis in renal transplant recipients: a case-based review.,0
Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.,1
"In two patients, adenosine precipitated acceleration of ventricular response, in one case necessitating emergent cardioversion.",0
Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described.,1
Four patients did not receive MB and all recovered only after 48 h.,0
"We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.",1
This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.,1
Four of the patients reported erectile dysfunction before beginning apomorphine and two of these report a significant improvement in their sexual function resulting from apomorphine use.,0
"To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.",1
One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.,1
"Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.",1
We present the case of a 5-year-old girl who developed bilateral vocal cord paralysis following preoperative peritonsillar bupivacaine infiltration.,1
Metformin-associated lactic acidosis precipitated by diarrhea.,1
We are unaware of any previous cases of statin-mediated unmasking of RMD.,0
"We report on a patient with subarachnoid haemorrhage who developed an acute life-threatening pseudo-obstruction of the colon, a variant of adynamic ileus, while being treated with intravenous nimodipine.",1
"Reported here is an unusual case of radiation enteritis which caused a severe sequelae of stricture in the transverse colon as a long-term effect of therapeutic irradiation for uterine cancer, and required a surgical resection.",0
Fibrosis of corpus cavernosum after intracavernous injection of phentolamine/papaverine.,1
"Atypical mycobacterial infections of the musculoskeletal system are very rare and are generally associated with predisposing factors, such as trauma, use of corticosteroids, or an immunocompromised state.",0
"Ordinarily occurring as a commensal, Kluyvera have been reported to cause serious infections in immunosuppressed and immunocompetent hosts, causing diarrhea, urinary infections, peritonitis, and cholecystitis.",0
Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.,1
This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.,1
The carers assessed the pre-morbid and present behaviour and personality of the patients using standard questionnaires.,0
"Antimycobacterial treatment, which led to a dramatic improvement within two months, was protracted for 18 months until the complete return to normal of both clinical and laboratory findings.",0
"CONCLUSION: During and after IFN therapy, OCT is a useful examination technique for revealing macular edema in patients who have decreased vision.",1
Imatinib mesylate therapy in patients with gastrointestinal stromal tumors and impaired liver function.,0
"In this brief report, we present case of successful cisplatin administration following two unsuccessful carboplatin desensitization attempts, and without the need for pre-treatment steroids.",0
"It is generally hypothesized to be due to a point mutation in the androgen receptor that allows the antiandrogen to function as an agonist, leading to a dramatic and rapid PSA response.",0
"Clinicians should consider early diagnostic amniocentesis in patients in preterm labor with a history of prior amniocentesis, and the routine Gram stain and culture of amniotic fluid.",0
Celiprolol pneumonitis.,1
"Identification of the BCG strain was performed in many sites, such as bone marrow, ganglionic mass, cerebrospinal fluid and in the site of vaccination.",0
Serotonin syndrome.,0
No virus particles were detected by electron microscope.,0
"She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.",1
We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.,1
"Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.",1
"His chemotherapy consisted of doxorubicin HCL, bleomycin, dacarbazine, and vinblastine, with prophylactic administration of a granulocyte colony stimulating factor.",0
"After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.",1
Nail-changes induced by penicillamine.,1
Information was reviewed for three of 538 volunteers who received PEG-rHuMGDF in clinical trials and two of 200 donors who underwent G-CSF mobilised stem cell harvesting procedures for sibling stem cell transplants.,0
We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.,1
"If confirmed, this observation may open new possibilities in intensive chemotherapy for patients for whom haematopoietic progenitors are difficult to harvest.",0
"Within 10 minutes, the occluded artery was reopened by an intracoronary (i.c.) infusion of streptokinase, resulting in the disappearance of chest pain and normalization of ST segments.",0
"The unusual severity and rapid spread of the infection, despite normal neutrophil count and prompt antifungal therapy, suggest that HIV-related immunocompromise might play a role in the impairment of host defences against Aspergillus infection.",0
We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.,1
"It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called ""3-week sulphasalazine syndrome"", a rare, but often fatal, immunoallergic reaction to sulphasalazine.",1
These cases and others quoted indicate that dependence on pressurized aerosol bronchodilators can and does occur in young people.,0
A 33-year-old woman visited our dermatologic clinic complaining of frequent oral ulceration for 10 years and generalized discoloration of her skin for 5 years.,0
We report 4 patients with involvement of 5 hips with septic arthritis in established osteonecrotic joints.,0
METHODS: Thirty-two patients with chronic hepatitis C were examined prospectively for changes in fundus findings while they were being treated with pegylated interferon and ribavirin.,0
Sirolimus-associated hepatotoxicity in the kidney graft recipient.,1
Angioedema and maculopapular eruptions associated with carbamazepine administration.,1
"Despite poor prognostic factors and extensive white matter lesions, the patient recovered dramatically with no need for maintenance steroid therapy.",0
We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.,1
"RESULTS: The patient was treated with immediate corticosteroids at the time of initial diagnosis, and emergent re-exploration and debulking of the paraspinal muscles.",0
"Diagnosis of invasive aspergillosis of the gut was based on abdominal pain, galactomannan antigenemia and isolation of Aspergillus fumigatus from the stool and was later confirmed by pathohistologic examination.",0
Bilateral simultaneous achilles tendon ruptures.,0
"CK and/or alanine aminotransferase and aspartate aminotransferase were increased 5-24 times above the normal range in four of these patients, and the muscle biopsy showed focal RML in all five.",0
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.,1
Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.,1
BACKGROUND: A healthy 37-year-old African- American man was receiving treatment with trimethoprim-sulfamethoxazole double strength.,0
"We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.",1
Reversible cholestasis with bile duct injury following azathioprine therapy.,1
Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.,1
"Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.",1
Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil.,1
Disulfiram-like reactions with newer cephalosporins: cefmenoxime.,1
Atenolol-induced pseudolymphoma.,1
Clinical recovery followed discontinuation of therapy and paralleled EEG resolution.,0
Bowel perforation associated with intraperitoneal chromic phosphate instillation.,1
The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.,1
"BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.",1
The mean time from starting MMF to the development of neutropenia was 4 months.,1
"Drugs are a major cause of this disease, and the list of culprits is continually expanding.",0
Peak serum concentrations exceeded 4 mcg/ml.,0
Treatment consisted of topical application of 0.1% tacrolimus ointment three times a day.,0
"Age at diagnosis was 43 +/- 3 years (range, 37-47).",0
Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection.,1
"PATIENT AND HISTORY: A 58-year-old man with GIST metastatic to the right lobe of the liver, treated with tyrosine kinase inhibitors, underwent a right hepatectomy requiring multiple transfusions.",0
The reason for occurrence of cutaneous reactions in interferon treated patients is unknown.,0
"BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.",1
"The syndrome is characterized by hyperuricemia, hyperphosphatemia, hypocalcemia, hyperkalemia, and acute oliguric or anuric renal failure due to uric acid precipitation within the tubules (acute uric acid nephropathy) and to calcium phosphate deposition in the renal parenchyma and vessels.We report a case of acute spontaneous TLS in a patient with Crohn s disease treated with immunosuppressive drugs, who developed a plasmocytoma, in which serum uric acid concentration attained exceptionally high levels (44 mg/dL).",0
A complete remission was achieved in 96% of children in relapse and in five out of six children resistant to induction.,0
The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily.,1
He was started on intravenous Zoledronic acid for reduction of bone pain and prevention of skeletal complication from multiple bone metastases.,0
Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.,1
Three patients presented with myoclonic seizures refractory to valproic acid and the usual antiepileptic therapy.,0
"A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a.",1
Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.,1
"Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as ""red man syndrome"" and anaphylaxis.",1
Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin.,1
"At 8 months after surgery, hair again covered his entire head.",0
Autopsy examination revealed obstruction of the small pulmonary veins with edematous thickening of the intima.,0
Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.,1
"Two cases of bipolar affective disorder with tardive dystonic symptoms seemed to improve only with mood elevation, whether the latter occurred spontaneously or was 'induced' pharmacologically.",0
"A complete clinical remission of the lymphadenopathy was obtained after infusions of rituximab (an anti-CD20 monoclonal antibody), acyclovir, and high-titer anticytomegalovirus immunoglobulin.",0
A 70-yr-old woman presented with a 9 cm left upper outer quadrant breast mass associated with overlying skin redness and a 2.5 cm left axillary mass.,0
The pharmacologic agent bisphosphonate has recently received much attention in the dental literature.,0
None of these patients experienced a relapse of their PTLD with follow-up ranging from 1.5 to 5 years.,0
Erythromycin is a macrolide antibiotic that may increase the risk of lovastatin-induced rhabdomyolysis.,1
Multiple seizures after bupropion overdose in a small child.,1
A 43-year-old patient with preexisting mitral valve prolapse and Cardiobacterium hominis endocarditis with partial destruction of the posterior mitral valve leaflet is described.,0
Keratitis in methamphetamine abusers.,1
Methadone-induced myoclonus in advanced cancer.,1
CONCLUSIONS: We present a case of a patient with CML who developed KS 12 months after starting treatment with imatinib 400 mg/d.,1
"We report a case of autoimmune hepatitis likely triggered by the use of black cohosh (Actaea racemosa), an agent marketed to treat menopause symptoms.",0
Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.,1
"Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.",1
"This case series demonstrates that secondary open-angle glaucoma can be a sight-threatening consequence, and periorbital steroids should therefore be used cautiously and sparingly, particularly in those with a family history of glaucoma.",0
The patient's isolate was susceptible in vitro.,0
We diagnosed this case as danazol induced thrombocytopenia.,1
Seven patients presented with refractory bleeding and 1 was diagnosed with severe coagulopathy unresponsive to the conventional treatment.,0
"Since recent studies have reported no negative interactions with concurrent use, we here report three cases (one case of a prolonged seizure, a serotonin syndrome and a focal seizure) of severe lithium-induced side effects while patients underwent ECT without complications and lithium serum levels were still subtherapeutic.",1
"We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.",1
"The tumor was not adherent to the dura, and its appearance was that of a typical neurilemmoma.",0
Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.,1
"While still receiving the drug or shortly thereafter, two patients were found to have abnormal dark-adaptation curves, with elevations of either cone or rod thresholds, or both.",0
A bone marrow aspiration showed slight hypoplasia with normocellular marrow.,0
"Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.",1
"Laboratory results indicated hypomagnesemia, hypocalcemia, hypokalemia, and hypophosphatemia.",0
The hospital course of the acute renal failure is presented with a review of the literature on cases of acute renal failure after IVIG.,1
"Bone marrow aspiration day +4 still showed hypo-normocellular marrow, with remaining 6% plasma cells.",0
"The patients were transferred to intensive care unit, and the treatment was continued after administration of corticosteroids under careful monitoring of vital signs without any further serious reactions.",0
Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.,1
"A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.",1
She received an alcohol-containing tylenol elixir while receiving the drug on two occasions.,0
"A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.",1
Unusual cause of methadone poisoning.,0
It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.,1
RESULTS: The in vitro hemodialysis model showed that ifosfamide was cleared with an extraction ratio of 86.7+/-0.5% and remained constant even at low concentrations of drug.,0
"CONCLUSIONS: This observation of ""on-off"" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent.",1
"Her condition improved, and she was discharged after 22 days.",0
Resolution occurred mostly within 24 to 48 hours after injection.,0
Patients were treated with CPA at the doses of 200-300 mg/d for malignant prostate disease for 3-12 mo prior to the acute manifestation of the hepatic disease.,0
"CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.",1
"The prevalences of hypertension, coma/unresponsiveness, seizures, and death were not as prominent in our study as previously reported, perhaps reflecting earlier recognition and intervention.",0
"However, spontaneous degenerative rupture of the plantar fascia is not well documented in the literature.",0
A patient developed optic neuropathy while being treated with isoniazid and ethambutol.,1
The treatment of choice remains operation.,0
Additive pulmonary toxicity with melphalan and busulfan therapy.,1
New therapies for MDR-TB have not been introduced since the fluoroquinolones in the 1970s.,0
These age-related differences in the pharmacokinetic profile of daptomycin have significant dosing implications.,0
The patient had leukocytosis with a large percentage of atypical lymphocytes on peripheral smear and liver dysfunction.,0
Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.,1
A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.,1
Herpetic reactivation may occur in many forms after excimer laser ablation.,0
"SSRIs and fentanyl are commonly co-administered, especially in the setting of chronic or malignant pain, as underlying depression may contribute to the pathogenesis of pain.",0
"CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.",1
"CASE SUMMARY: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.",1
Results of his mycologic examination and cultures came back negative.,0
Cough induced by quinapril with resolution after changing to fosinopril.,1
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.,1
Seizures in patients receiving concomitant antimuscarinics and acetylcholinesterase inhibitor.,0
Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia.,1
Concomitant irradiation apparently enhanced the skin toxicity of aminoglutethimide or possibly aminoglutethimide had a radiosensitizing role in this patient.,1
"The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.",1
"Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.",1
"Vascular catheters are associated with complications such as infection, thrombosis and stenosis.",0
Anhedonic ejaculation with desipramine.,1
"TD was relatively mild, with a mean score of 4.75, and tended to accentuate with an activation procedure of rapid pronation and supination of the hands.",0
"Neurological examination revealed bilateral ptosis, and complete external opthalmoplegia with normal pupillary and corneal reflexes.",0
Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.,1
She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.,1
"Several years after the original diagnosis, he was found to be ACTH deficient and following commencement of hydrocortisone replacement therapy became hypernatraemic.",0
"One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).",1
"Rofecoxib, used for dysmenorrhea, caused a herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand.",1
Type 1 diabetes mellitus provoked by peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.,1
Patch testing to individual components revealed positive reactions to all ingredients except aloe.,0
"CONCLUSION: ECT with muscle relaxants could be administered safely, with appropriate precautions kept in mind.",0
"However, many of the patients had been treated surgically for recurrences once or several times previously.",0
"We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.",1
The objective of this paper is to provide data regarding early and suspected cases as well as offer guidelines for managing this condition.,0
"We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.",1
OBJECTIVE: To report a case of decreased international normalized ratio (INR) in a patient receiving warfarin and bosentan.,0
"The patient's clinical presentation, histologic features on liver biopsy and favorable course after stopping the drug suggest that barbiturates can be added to the list of agents which can cause submassive hepatic necrosis.",1
The clinical setting and diagnostic evaluation suggest multiple mechanisms for the hypersensitivity response.,0
A case of mania associated with fluoxetine.,1
"PARTICIPANTS: Four patients (3 with spinal cord injury, 1 with cerebral palsy) with implanted ITB infusion pumps for treatment of severe spasticity, who had ITB withdrawal syndrome because of interruption of ITB infusion.",0
"The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.",1
RESULTS: Six patients with CSC were found to be chronic users of corticosteroid (four patients) or both beta adrenergic agonist and corticosteroid (two patients) metered dose inhalers or nasal sprays.,0
The ocular motor disturbances are probably an expression of regional 5-FU neurotoxicity primarily affecting the brain stem.,1
"Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.",1
"Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.",1
Magnetic resonance imaging appearance of the shoulder after subacromial injection with corticosteroids can mimic a rotator cuff tear.,0
Chemotherapy followed by peripheral blood cell autotransplantation led to complete disappearance of the pancreatic and mediastinal masses.,0
CONCLUSIONS: PHD may play an important role in cases where macular thickness is successfully reduced or better acuity is achieved after intravitreal injections.,0
"Successful use of Shakuyaku-kanzo-to, a traditional herbal medicine, for intractable symptoms of thoracic outlet syndrome: a case report.",0
Serotonin syndrome in the perioperative period.,0
The patient's autoimmune thyroiditis may also contribute to the predisposition for pemphigus development.,0
We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.,1
CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide.,1
"We report the case of a 17-year-old male who developed chest pain, elevated cardiac biomarkers, and acute left ventricular dysfunction following a single dose of methylphenidate.",1
No cerebral lesion was detected.,0
The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.,1
"Median survival ranges from 15 to 24 months, and it appears that the disease cannot be cured.",0
Neuroleptic malignant syndrome and neuroleptic-induced catatonia: differential diagnosis and treatment.,0
Desipramine-associated SIADH in an elderly woman: case report.,1
Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.,1
the disease has been described mainly in patients treated with systemic corticosteroids (39 cases out of the 71 reported cases) or local corticosteroids (3/71) and in patients suffering from Cushing's syndrome (7/71) but rarely in HIV-infected patients (3/71).,0
Intra-arterial adriamycin chemotherapy for bladder cancer.,0
Serum potassium values higher than 7 mmol x l-1 are associated with cardiac arrhythmias and an increased incidence of intraventricular haemorrhage and periventricular leucomalacia.,0
Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.,1
Persistent light reactivity from systemic quinine.,1
"In each case, renal dysfunction and BK viral load progressed despite reduced immunosuppression, and persistent BK virus infection was documented in serial renal allograft biopsy specimens.",0
Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.,1
"Bladder biopsies demonstrated massive eosinophilic infiltration of the bladder, confirming the diagnosis of eosinophilic cystitis.",0
"Therefore, these patients might have to be treated with granulocyte colony-stimulating factor to be able to recover from severe neutropenia.",0
BACKGROUND: Angiosarcoma arising after radiation is described in breast cancer but occurs elsewhere.,0
Acute erythroleukemia complicating prolonged chemotherapy for ovarian carcinoma.,0
"The authors suggest that risperidone may increase affect in patients with schizophrenia and that some patients, especially those with anxiety, may have difficulty managing the increase.",1
Methylphenidate-associated enuresis in attention deficit hyperactivity disorder.,1
Remissions following total body surface treatment varied from two weeks to at least four months.,0
10 months later all studied cells in the marrow contained this deletion.,0
"S-1 is an oral 5-fluorouracil (5-FU) anticancer agent and has shown promising effects in the treatment of a wide range of carcinomas, including head and neck cancer.",0
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.,1
Medical consultation is imperative for these patients before administering a fluid challenge during general anesthesia.,0
Quinine-induced hearing loss.,1
"Within 24 h after the first injection to her left arm, the patient developed pruritus and erythematous papules at the injection site and painful papules on her hands.",0
"The neurological symptoms and signs were headaches, right quadrant hemianopia, dyslexia without agraphia, motor aphasia, numbness in and weakness of the right upper extremity, papilloedema and coma.",0
Five days of treatment with ketoconazole alone was ineffective in our patient's infection.,0
The report is followed by a brief review of anticonvulsant hypersensitivity syndrome and DRESS.,0
"To our knowledge, this is the first report of an angio-oedema associated with VRC.",1
"Acute nitrite toxicity results from industrial exposure, accidental ingestion (e.g., abuse of organic nitrites as an aphrodisiac, especially in the male homosexual population), and suicidal ingestion.",1
CONCLUSIONS: Rasburicase appears to be well tolerated and effective in lowering serum urate concentrations in the treatment of therapy-related TLS in neonates.,0
Liposomal amphotericin B in drug-resistant visceral leishmaniasis.,0
"A transdermal scopolamine patch is an effective medication for relieving motion sickness, treating nausea and vomiting from chemotherapy and decreasing withdrawal side-effects from wearing off opioids.",0
A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.,1
This case suggests that acute pancreatitis was due to intolerance of high-concentration lipid emulsion.,0
"Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.",1
"Laboratory studies demonstrated eosinophilia, elevated serum IgE, and elevated T suppressor/cytotoxic cells in the peripheral blood.",0
We describe a 41 yr old leprosy patient treated for 10 yrs with clofazimine who underwent laparotomy for severe abdominal pain.,1
"Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.",1
Voriconazole (VRC) has not previously been reported to cause angio-oedema.,1
"CASE: A 29-year-old primigravida with a history of four therapeutic amniocenteses for idiopathic polyhydramnios developed preterm labor at 30 and 5/7 weeks' gestation, rupture of membranes, and Candida albicans chorioamnionitis.",0
It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.,1
"In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.",1
We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.,1
"Respiratory distress, severe VOD and grade II acute gastrointestinal GVHD complicated the post-transplant period.",0
Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.,1
"The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.",1
"We present three cases from the Provincial Toxicology Center of British Columbia, Canada in which suicidal overdose deaths were associated with quetiapine.",1
"Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.",1
Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.,1
"The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.",1
"Second malignancy is one of the late complications of long-term cancer survivors, treated with radiation or chemotherapy.",0
The clinical activity of sirolimus in PEComa additionally strengthens the pathobiologic similarities linking PEComas to other neoplasms related to the tuberous sclerosis complex.,0
CPH is exquisitely responsive to indomethacin so much so that the response is one of the current diagnostic criteria.,0
After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.,1
"INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.",1
She had had her tongue painted with silver nitrate repeatedly 6 years ago for the treatment of oral ulcers.,0
"After 20 months of therapy on etanercept, his plaque psoriasis markedly improved, whereas both his fasting blood sugars and glycosylated hemoglobin A(1c) decreased.",0
Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects.,1
"Despite the risk of needle-track seeding, PEI remains useful in the treatment of HCC.",0
"The association of the use of certain androgenic steroids with hepatic neoplasms histologically resembling hepatocarcinomas, but characterized by lack of metastases and apparent reversibility, suggests the desirability of a new nomenclature for these hepatocellular lesions.",0
"Liver function continued to deteriorate, and the patient underwent liver transplantation 17 days after admission.",0
Renal tubular acidosis secondary to FK506 in living donor liver transplantation: a case report.,1
A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma.,1
"A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.",1
Combined intoxication with a tricyclic antidepressive agent and a neuroleptic.,0
"This is the first reported case of BOOP associated with single-agent rituximab, and along with two other patients we describe, as well as two prior reports of BOOP in NHL patients receiving rituximab-based combinations, strengthens the possibility of a causal relationship.",1
"After discontinuing captopril and starting systemic steroids, her symptomatology rapidly improved, and her eosinophilia and radiographic abnormalities both resolved.",1
Adrenaline dacryolith: detection by ultrasound examination of the nasolacrimal duct.,1
Long-term lithium treatment attenuated the hypokinetic effect of reserpine in a patient with tardive dyskinesia.,0
Strongyloides hyperinfection in a patient with sarcoidosis.,0
Nonconvulsive status epilepticus: the role of morphine and its antagonist.,1
The only residual neuroblastoma tissue visible on MIBG scintigraphy on day 150 of treatment was a metastasis in the left tibia which was irradiated with 24 Gy.,0
"OBSERVATIONS: In both patients, at the time of the visual disturbances, macular edema was clearly observed by OCT.",0
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.,1
A paradoxical ocular effect of brimonidine.,1
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"From September 5 to November 4, 1991, four consecutive patients placed on centrifugal ventricular assist devices (VADs) for cardiac failure were supported with Biomedicus pumps coated with the Carmeda bioactive surface.",0
The relationship between this paraneoplastic endocrine syndrome and the clinical course of the tumor is examined in this review of patients with the ectopic ACTH syndrome and small cell carcinoma seen at The Johns Hopkins Oncology Center between 1973 and 1979.,0
No relapse of endocarditis was observed after 12 months of follow-up.,0
"We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy.",1
"Since propylthiouracil is an equally effective antithyroid agent and has not been associated with ACC, it is the preferred thioamide for hyperthyroidism during pregnancy.",0
All patients except two had new recurrences within the observation time.,0
Proponents of the use of fluoroscopy cite studies that report up to 35% rates of inaccurate placement of epidural needles without the aid of fluoroscopic imaging.,0
"Although the current metabolism of the 2 drugs in combination is poorly understood, the potential for serious interactions seems to exist in the rapidly growing population of persons with asthma, for whom they may be prescribed.",0
This responded well to steroids and cyclophosphamide.,0
Thalidomide neuropathy in childhood.,1
Valproate-induced hyperammonemia as a cause of altered mental status.,1
"Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.",1
"However, thin conjunctiva is susceptible to mechanical injury and is difficult to repair with suturing, especially when the point of leakage is close to the scleral flap.",0
OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.,1
"This outbreak demonstrates the ability of drug-resistant Salmonella to spread from the animal to the human reservoir and, in a suitable host, produce a fatal infection.",0
"Polyacrylamide gel may have favorable properties for facial tissue augmentation, but a severe granulomatous inflammatory response induced by injection of polyacrylamide gel may occur.",0
In four patients the maximum ST elevation was greater than or equal to 5 mm.,0
Magnesium toxicosis in two horses.,1
"We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension.",1
Discussion includes a review of the literature with respect to the relative merits of daily oral cyclophosphamide versus pulse intravenous cyclophosphamide in WG and other vasculitides.,0
Compared to the normal study protocol side-effects such as renal failure were not observed probably due to sufficient fluid intake and good clinical condition prior to treatment and to the rapid and persistent ductal closure.,0
Gold-induced pneumonitis is a rare complication of gold salt therapy.,1
AIMS: The aim of this study was to report on the effectiveness and tumor side effects of topical interferon (INF) alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia (CIN) of a patient that rejected any surgical procedure.,0
Ampicillin-induced interstitial nephritis with generalised exfoliative dermatitis.,1
Initial treatment with itraconazole resulted in exacerbation of clinical signs.,0
A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.,1
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
"However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.",1
"We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.",1
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
Renal biopsy three weeks after the onset of renal failure revealed evidence of focal renal cortical necrosis.,0
The patient had been treated successfully in the hospital with intravenous methylprednisolone.,0
Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.,1
Hypoglycemia induced by long-acting somatostatin analogues in a patient with nonfunctional neuroendocrine tumor.,1
"Clinical and histological information on three additional patients seen at two institutions (Rochester Methodist Hospital, Rochester, MN, and Fairview-University Medical Center, Minneapolis, MN) by the authors were also compiled.",0
"A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).",1
Most breaches are not considered harmful.,0
"Streptococcus pneumoniae was more frequently eradicated in the azithromycin than in the ceftibuten group, whereas gram-negative bacilli were more susceptible to ceftibuten.",0
Adverse events with anti-epidermal growth factor receptor therapy mainly involve the skin.,0
Yoga neuropathy.,0
"After 1 week of nefazodone therapy the patient experienced headache, confusion, and ""gray areas"" in her vision, without abnormal ophthalmologic findings.",1
"Cryoglobulinemic MPGN was suspected and kidney biopsy was performed, resulting in a diagnosis of minimal change disease (MCD).",0
Intravenous were started and a below knee amputation date of admission under spinal anaesthesia.,0
the treatment was administered in a two-step process.,0
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
Delay of corneal wound healing in patients treated with colchicine.,1
One patient had breast cancer with multiple distant metastasis and received palliative radiotherapy to the spine and hip joint.,0
On admission she was unconscious with absent brainstem reflexes and multifocal stimulus-sensitive myoclonus.,0
"Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.",1
Hemoglobin electrophoresis and methemoglobin reductase determinations were normal for age.,0
Specimens of thyroid tissue from two cases with Hashimoto's thyroiditis were immunohistochemically examined for expression of SSTR2A.,0
Transvaginal ultrasonography is a very sensitive test and therefore is often performed as a first-line screening test.,0
"In this report a renal transplant recipient is described, who developed disseminated Nocardia asteroides infection with lung, eye, and brain involvement, in addition to coinfection with Trichophyton rubrum.",0
"The patient was hospitalized and chelated with EDTA four times over the next 5 years; each time he felt better at the end of his treatment, but he returned to largely the same working conditions.",0
"Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.",1
"Her physical appearance, elevated and relatively nonsuppressible plasma cortisol levels, and radiologic study supported a tentative diagnosis of Cushing's syndrome in a critically ill patient.",0
"Studies for disseminated intravascular coagulation remained stable, and no clinical bleeding was seen.",0
On investigation no new change was noticed than previous evaluation.,0
There were 5 outpatients who suffered chronic pain for at least 3 months.,0
Doxycycline-induced photo-onycholysis.,1
PURPOSE: To report a case of nodular scleritis following alendronate sodium.,1
Asterixis induced by carbamazepine therapy.,1
"Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.",1
Valproate 960 mg (30 mg/kg) was infused over 1 hour.,0
"At postmortem examination the cerebral hemispheres had a conspicuous destruction of white matter, consistent with a necrotizing leukoencephalopathy with focal and diffuse demyelination.",0
We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).,1
The visual loss in this patient seems to result from phenol neurotoxicity rather than mechanical compression of the intraorbital optic nerve.,1
We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.,1
"BACKGROUND: Tamoxifen, a widely used drug in adjuvant therapy of breast carcinoma, is now being tested for its effectiveness in chemoprevention.",0
"It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.",1
A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis.,1
This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.,1
"In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.",1
We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.,1
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
Careful review of the literature suggests that corticosteroid-induced liver damage may be more frequent than commonly believed.,0
Allergic contact dermatitis to compound tincture of benzoin.,1
"We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.",1
"The syndrome of ""painful legs and moving toes"" is characterised by spontaneous causalgic pain in the lower extremities associated with peculiar involuntary movements of the toes and feet.",0
"We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.",1
"Strong expressions of PDGF-B and IGF-1 on alveolar macrophages and type II pneumocytes were clearly demonstrated, but in contrast, the expressions of TGF-beta1 and COX-2 were almost undetectable.",0
Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.,1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
No systemic antibiotics would be given.,0
Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.,1
Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.,1
Early bacterial keratitis after laser-assisted subepithelial keratectomy.,0
A patient with adenocarcinoma of the prostate with bone metastases experienced dyspnea possibly related to the ingestion of these tablets.,0
"Following this incident, the patient was seen weekly and treated with conjugated vaginal oestrogen cream.",0
The potential arrhythmogenic effects of alcohol have recently been studied electrophysiologically.,0
"In this paper, we report a case of severe hypercalcemia of immobilization in a 40-year-old hemodialyzed woman treated by cinacalcet HCl for a severe HPTH-II (PTH>1,000 pg/mL).",1
Laboratory investigation disclosed a high anti-Toxoplasma IgG titer.,0
A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.,1
"He stopped this therapy in February 1996 because of asthenia, diplopia, headache, and anxiety.",0
"Then, she again started taking theophylline (75 mg twice daily), and over 2 days reached a steady state serum theophylline level of 12.8 to 14.4 micromol/L (2.3-2.6 microg/mL).",0
"This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.",1
"However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.",1
"Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.",1
Initial treatment including removal of the catheter and antibiotic therapy was unsuccessful and both patients had persistent fever and bacteremia.,0
"However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.",1
"Biochemical, bacteriological and imaging studies were performed for specific diagnosis.",0
Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.,1
Phenylpropanolamine-induced psychosis.,1
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI.,1
"We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy.",1
"Alertness returned over the 24 hr following by the discontinuation of BH-AC and intravenous administration of diphenylhydantoin, although she complained of intermittent headaches and visual disturbance.",0
"The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.",1
"She was treated with Pancrease MT 16, but had consistent vomiting 1 to 2 hours after administration of enzymes.",1
This disease is caused by inherited defects of the insulin receptor and is lethal early in life.,0
Nephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapy.,1
"However, it failed in 1 case requiring transabdominal transperitoneal closure of the fistula with an interposition of omentum.",0
"This experience supports the hypothesis that heparin can be readministered early to patients with heparin-associated thrombocytopenia and thrombosis, provided antiplatelet therapy is given.",1
"The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered.",0
This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.,1
Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity.,1
"Because the AKBR changes in relation to electron transport in liver mitochondria, it seems to be a logical parameter for evaluating the effect of potassium cyanide poisoning on electron transport.",0
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.,1
"In patients with methotrexate-induced anaphylaxis, discontinuation of treatment may increase the risk of death due to cancer progression.",1
We report AZA-induced drug eruption that developed in two cases of systemic scleroderma with polymyositis.,1
"One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).",1
Intraarticular sodium hyaluronate injection to treat osteoarthritis is associated with minor side effects.,0
Hepatitis C virus RNA was negative after 12 mo of treatment.,0
"The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.",1
Large dose of methylphenidate may cause cataract and glaucoma.,1
OBJECTIVE: To report a case of possible foscarnet-induced severe hypomagnesemia and other electrolyte disorders.,1
METHODS: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder).,1
Eighteen tablets (72 mg) of her tiagabine prescription were missing.,0
Safety of nab-paclitaxel plus sunitinib: analysis of three cases.,0
"The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.",1
Severe apnea in an infant exposed to lamotrigine in breast milk.,1
We studied the hypothalamic-pituitary-adrenocortical axis in two female patients before and during treatment with CPH82.,0
A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia.,1
"Contributory factors probably included pharmacokinetic interactions with co-administrated drugs, vitamin K deficiency caused by decreased dietary intake, reduced gut bacterial production, impaired intestinal absorption and hepatic synthetic capacity, and increased consumption of clotting factors.",0
One patient had partial responses in both treated tumors.,0
Clinical recovery required an average of 42 days and was complete in four of five patients.,0
Alopecia is an adverse effect in those patients taking aromatic anti-convulsant drugs but is rarely reported after discontinuing such medications in the convalescent status of anti-convulsant hypersensitivity syndrome (AHS).,0
This report describes a case of acute compromise of renal function associated with hypotension in a 7-year-old boy treated with the ACE inhibitor lisinopril and the ARB losartan.,1
Ulcerating enteritis associated with flucytosine therapy.,1
The mechanism by which ciprofloxacin causes these adverse effects is not fully understood.,0
The predominant feature was the abnormally increased formation of both 3 mono- and 4 double unsaturated metabolites of VPA amounting in plasma to 58%-71% of the sum of VPA plus all analyzed metabolites (controls maximal 15%) and in urine to 34%-61% (controls maximal 10%).,0
Only one prior case has been reported in a patient receiving aggressive chemotherapy for a hematologic malignancy.,0
She was discharged without any neurologic sequela.,0
METHODS: Case reports and associated biopsy findings.,0
"We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.",1
We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.,1
"We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.",1
"The case reports are followed by a brief review of the literature on differential diagnoses, risk factors, early signs and treatment data.",0
"Glutathione levels were low before treatment, and increased during treatment.",0
CONCLUSIONS: This case report is part of a new and growing body of literature that demonstrates the potential risk of transforaminal injection.,0
The development of methods to prevent or decrease peritoneal sclerosis will allow for greater application of this innovative therapeutic approach.,0
We present a pediatric patient who developed cutaneous T-cell lymphoma with mycosis fungoides histology after liver transplantation.,0
The patient's visual acuity was 6/20 (non-corrected) in the right eye and 6/10 (-1.75/-1.00 x 91) in the left.,0
Albuterol-induced hypokalemia and its potential cardiac toxicity are discussed briefly.,1
An outbreak of multiple-drug-resistant Salmonella enteritis from raw milk.,0
One major source of risk to patients is intraarterial or intraneural injections.,0
"RESULTS: At our institution, no children appeared with acute INH neurotoxicity in the period 1985 through 1990, whereas seven patients were treated from 1991 through 1993.",1
Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.,1
Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.,1
Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.,1
This theory was supported by disturbances in serine and glycine excretion found in all patients during psychotic episodes.,0
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.,1
Paradoxical seizures in phenytoin toxicity.,1
We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.,1
"While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.",1
"Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.",1
"Despite early complete paraplegia, some neurological and functional recovery was observed.",0
"On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.",1
A 42 year old male with gram negative pneumonia complicated by deep venous thrombosis was followed throughout his hospital stay and for two weeks following discharge.,0
We believe that a pharmacodynamic interaction is most likely.,0
The time delay by which symptoms of pancreatitis presented following administration of loop diuretics suggests an immunologic pathway.,0
The patient was also found to have Hashimoto's thyroiditis.,0
Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.,1
Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.,1
"CASE REPORT: A 52-year-old woman presented with an extensive flare of psoriasis associated with joint pain, especially in her knees and elbows.",0
"Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.",1
We believe serum triglyceride levels should be monitored in patients who have other cardiac risk factors and are receiving clozapine.,0
This report emphasizes the unnecessary hazard accompanying use of a potentially toxic drug-especially when prepared in error by the pharmacist-when a safer drug (nystatin) is available for treatment of oral candidiasis.,0
The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.,1
"We report a case of a 26-year-old woman, who presented with an itchy erythematous reaction and strong oedema localized to the face.",0
Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies.,1
We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.,1
The neurological manifestations developed within one week after the last dose of Ara-C and persisted for over 8 weeks.,0
Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin.,1
"Though they are generally considered safe, there have been a few reports of myocardial infarction and stroke associated with triptan use.",1
An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.,1
This observation also suggests that early administration of ribavirin in patients affected by acute syncytia; giant cell hepatitis of unknown origin could avoid liver transplantation.,0
The association of infiltrative ophthalmopathy with primary hypothyroidism is uncommon.,0
Pathological examination of both resected femoral heads showed no intravascular thrombosis.,0
"Soon after the third weekly session of the second protocol, the clinical status of the animal deteriorated suddenly and severely, with a bleeding tendency, jaundice, hyperuricaemia, hyperphosphataemia, azotaemia, hyperbilirubinaemia and, presumptive disseminated intravascular coagulation.",0
"CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.",1
Emergency selective coronary angiography was performed.,0
Several also reported improved sleep at night.,0
"Although arachnoiditis, infection, and meningitis have been reported, acute paraplegia has not been reported as a complication of either caudal or spinal epidural steroid injection.",0
"Retinal abnormalities, including retinal hemorrhage and ""cotton-wool"" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.",1
Screening for celiac disease with detection of anti-endomysium antibodies would be done in susceptible patients.,0
Misdiagnosis in all three patients led to inappropriate topical corticosteroid use.,0
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
STUDY DESIGN: A case report.,0
"The increasing incidence of both atrial fibrillation and colon cancer with age could potentially require the concomitant use of 5-FU, levamisole, and warfarin.",0
Extensive microbiological investigation remained negative and video-assisted thoracoscopic lung biopsy demonstrated diffuse alveolar damage.,0
"In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.",1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
Seizures associated with fluoxetine therapy are uncommon.,1
"We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).",1
Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.,1
Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient.,0
Glatiramer acetate is administered by subcutaneous injection once daily.,0
The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.,1
There was no residual corneal scarring.,0
"METHODS: [1] Trachea specimens excised from 15 healthy ferrets were incubated in culture plates lined with 200 mg of VVR, and the mucin secretion was compared to those from controls without VVR.",0
The patient was successfully treated with medical management and insertion of an implantable cardioverter defibrillator.,0
"Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.",1
"Eight patients developed a total of 12 episodes of sudden, massive vitritis.",0
We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.,1
"A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.",1
"Excluding other causes, Pentasa-associated pancytopenia was considered.",1
"The decedent was also prescribed tramadol, gabapentin, cetirizine, modafinil, carisoprodol, and Xyrem.",0
NMS must be considered as part of the differential diagnosis of fever in burn patients receiving medication known to cause the syndrome.,0
Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.,1
OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.,1
"Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.",1
He experienced a severe skin reaction diagnosed as toxic epidermal necrolysis.,0
In the last years intravenous cyclosporine (CyA) has been reported to be rapidly effective and relatively safe in patients with severe corticosteroid-resistant UC.,0
The edema disappeared within 24 hr after stopping the infusion therapy.,0
"A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.",1
"The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.",1
"Candida dubliniensis is an emerging fungal pathogen, especially in immunodeficient patients.",0
The second patient underwent peritoneal dialysis and also had significant problems with hypertension.,0
"The mean histologic activity index scores for patients in groups 1 and 2, respectively, were 6.7 and 5.4.",0
"We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.",1
Peripheral neuropathy was not fully reversed in all patients.,0
"Two weeks later, the patient went to a local emergency department after experiencing two brief syncopal episodes.",0
CONCLUSIONS: RPE tear is a complication that may occur following PDT in particular when the PDT is applied to an occult subfoveal CNV.,0
Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).,1
Her platelet counts were never less than 75% of baseline and were consistently above 200 x 10(3)/mm(3).,0
RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.,1
"The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).",1
"SETTING: Spinal cord rehabilitation center, University Hospital.",0
"However, we cannot exclude a primitive effect of erythropoietin on the endothelium or on the platelets.",0
"By the time of treatment stabilization, the patient had not experienced any further fits.",0
"In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.",1
A marked decrease in uterine size occurred within 12 months of insertion accompanied by resolution of the menorrhagia and dysmenorrhea.,0
Gastrointestinal hemorrhage due to duodenal erosion by a biliary wallstent.,0
"The hazards of treating such patients with lithium are well known (Lazarus & Gilgor, 1979), but other drugs may also destabilize psoriasis.",0
"RESULTS: The patient tolerated this fairly well and has been on this treatment and regular diet for >1 year, without any adverse reaction.",0
"In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.",1
IgG1 and IgG4 were the predominant IgG subclasses in the glomerular deposits.,0
Decreased plasma cortisol level during alprazolam treatment of panic disorder: a case report.,1
They suffered from severe (one case) or moderate (two cases) hemopoietic form of acute radiation sickness (ARS).,0
The patient' condition improved after rapid tapering of her epoprostenol and administration of corticosteroids.,0
Optic neuropathy in ethambutol-treated renal tuberculosis.,1
"A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).",1
Semiselective intra-arterial chemotherapy with compression of the femoral arteries at the time of injection.,0
Measurements of the peripheral arterial circulation were made using the Doppler ultrasonic velocity detector.,0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.",1
"One patient died of an arrhythmia that deteriorated into asystole, and 2 patients recovered and underwent coronary angiography.",0
We report a case of a 65-year-old man suffering from a dilatative cardiomyopathy and concomitant MRSA infection who received a biventricular assist device.,0
The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin.,1
"Aspirin was substituted for acenocoumarol, and the patient returned home after 10 days without sequelae.",0
These results suggest that the pathogenesis of pseudotumor cerebri might be associated with the hypercoagulable state which was induced by glucocorticoid therapy and nephrotic syndrome.,0
Teamwork and skillful airway management prevented this patient's demise.,0
"To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.",1
"NE occurred 7-10 days after the completion of chemotherapy, during the neutropenic phase.",0
Ethambutol toxicity manifesting as acute onset psychosis.,1
Drug-induced linear IgA disease with antibodies to collagen VII.,0
The patient was intubated with ventilator support and improved after his metabolic acidosis resolved.,0
"The co-occurrence of bingeing, irritability and anterograde amnesia is suggestive of a drug-induced Kleine-Levin Syndrome.",0
CONCLUSIONS: We report this case of the concomitant appearance of multiple skin cancers and nail changes associated with hydroxyurea use.,1
"Once the diagnosis was made, he was treated with adrenaline and made a full recovery.",0
SCA2 may present as levodopa-responsive parkinsonism.,0
"We conclude, this novel mode of intra-operative local chemotherapy by spray application of fibrin glue containing antineoplastic agent is effective in the control of residual tumor progression and may also prevent local recurrence and hence suggests its possible role as an adjuvant therapy in the management of malignant gliomas.",0
Hepatotoxicity after high-dose methylprednisolone for demyelinating disease.,1
"A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",1
Adrenal suppression and failure to thrive after steroid injections for periocular hemangioma.,0
"We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.",1
"Nurses can be instrumental in minimizing the impact of these conditions by monitoring the longitudinal trends in Hb levels, proactively assessing patients for inflammatory or infectious conditions, and intervening to resolve causative conditions and minimize the impact on anemia.",0
"The dog made a gradual recovery, with complete return of locomotor function and muscle mass within 2 months.",0
"It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum.",0
"Topical steroids remain the mainstay of therapy, but topical tacrolimus has recently been used to treat OLP resistant to topical corticosteroids.",0
There has been no literature which reports a case of interstitial lung disease associated with sorafenib.,0
"Sorafenib, a multitargeted kinase inhibitor used for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinomas, received FDA approval in 2005.",0
Infant twins sustained severe circumoral and pharyngeal burns from a concentrated solution of benzalkonium (Zephiran) chloride prescribed for treatment of candidiasis.,1
Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.,1
Computed tomography of the head performed immediately after recognition of the symptoms showed a hyperdense middle cerebral artery (MCA) sign.,0
Synergistic effect of carbapenem-teicoplanin combination during severe Rhodococcus equi pneumonia in a kidney transplant recipient.,0
"While exclusion of any bacterial infection and screening for tuberculosis are mandatory before initiating a therapy with anti-TNF-alpha-antibodies, there are no guidelines whether to screen for or how to deal with chronic viral infections such as hepatitis B.",0
"Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.",1
"Following prompt recognition and diagnosis, intravenous thrombolytic therapy was administered 2 hours after symptom onset.",0
"He had miliary tuberculosis, renal failure requiring dialysis and visual disturbances.",0
"Isoniazid associated, painful, bilateral gynaecomastia.",1
We present 2 patients with demonstrated IgE-mediated allergy to cloxacillin and tolerance to amoxicillin and cefuroxime.,0
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
"Milk-alkali syndrome induced by 1,25(OH)2D in a patient with hypoparathyroidism.",1
The favourable influence of PCS on the depressive syndrome is considered to be largely linked to the anticholinergic effect of the drugs.,0
"After other potential causes of liver toxicity were excluded, TMP-SMX was determined to be the cause of his acute liver toxicity.",1
Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.,1
"To the authors' knowledge, this is the first report in the English-language literature of spontaneous neonatal intracerebral hemorrhage, due to thrombosis of the superior or inferior vena cava.",0
Audiograms showed bilateral sensorineural hearing loss with cochlear lesions.,0
Typhlitis during second-line chemotherapy with pemetrexed in non-small cell lung cancer (NSCLC): A case report.,0
"We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.",1
The drug may also accumulate irreversibly on the posterior surface of the cornea and on the anterior surface of the lens.,0
"Five of 610 adults developed chickenpox between 35 days and 9.2 years after renal transplantation, and only one patient survived.",0
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.,1
The possible deleterious effects of praziquantel therapy should be considered in the treatment of patients with subarachnoid cysticerci.,0
Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.,1
A 42-y old woman swallowed 60 ml of 50% malathion in a suicide attempt.,0
Two case reports.,0
"Ptosis occurring 24 h after chloroquine therapy, with full recovery 48 h after cessation of chloroquine, has not been described previously.",1
PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.,1
Epsilon-aminocaproic acid (EACA) is a potent anti-fibrinolytic agent that is used in the treatment of excessive bleeding resulting from a systemic fibrinolytic state.,0
"It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.",1
A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis.,1
Skin biopsies confirmed scrofuloderma and the patient was successfully treated for tuberculosis with resolution of the brain masses.,0
"We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.",1
Priapism associated with zuclopenthixol.,1
"These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.",1
The risk of developing BMTN may be greater with the use of more intensive chemotherapy and higher total body and tumor bed irradiation.,0
"A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands.",1
A case of acute cardiomyopathy and pericarditis associated with methylphenidate.,1
CLINICAL PRESENTATION: Spine pain may precede neurologic deterioration by many hours.,0
"Several clinical parameters indicate a remarkable improvement in the clinical courses of those patients in recent years: weaning time, extubation rate, and improvement of additional organ failures were all significantly better in patients treated after the emergence of new antimycotic agents, resulting in prolonged overall survival.",0
"CONCLUSIONS: Early recognition of this serious pharmacogenetic syndrome may allow for the modification of future chemotherapy, thus avoiding further life-threatening toxicities.",0
Actinic prurigo and solar urticaria are uncommon chronic idiopathic photodermatoses in the United Kingdom.,0
"Before recognition of pregnancy, the latter had been treated for acute myelocytic leukaemia receiving cytarabine, daunorubicin and doxorubicin at conception and cytarabine and thioguanine at about 35-37 days post conception.",0
Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.,1
Asthmatic patients receive multiple drugs as part of their treatment program.,0
"Thus, perospirone is an agent with possible efficacy for medication-refractory schizophrenia.",0
Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.,1
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.,1
"Evaluation at another laboratory showed normal levels of TSH, raising the possibility of interfering substances.",0
"This patient, who also had an abdominal aortic aneurysm, survived, on discontinuation of her anticoagulant therapy.",0
Methotrexate-induced papular eruption following treatment of psoriasis.,1
"Chromoblastomycosis, or chromomycosis, is a chronic fungal infection of the skin and subcutaneous tissues caused by a species of dematiaceous fungi.",0
We report a case of ST elevation in right precordial leads compatible with type 1 Brugada syndrome following administration of propafenone in a patient with Wolff-Parkinson-White syndrome who was receiving lithium at concentrations within therapeutic levels.,1
"A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).",1
We also review DCL to emphasize the importance of recognizing and treating this evolving disease in the growing population of patients on immunorestorative therapy.,0
"Five patients (ages 23-52; UNOS status 3-4) exhibited a characteristic pattern of stuttering dysarthria, leading to complete loss of speech production, occasionally with elements of aphasia.",0
A case of nephrotic syndrome treated with associated cyclophosphamide and corticosteroids came to our attention after over 2 years of self-administered immunosuppressive therapy which remained unchanged and uncontrolled during this period.,0
"Although the relationship between antipsychotic medication, particularly second-generation antipsychotics (SGAs), and metabolic disturbance is increasingly accepted, there is an important, but little recognised, potential interaction between this and the other important serious adverse effect of neuroleptic malignant syndrome (NMS).",0
"A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.",1
Seven patients with rheumatoid disease were given the iron-chelating drug desferrioxamine (DFX) to evaluate its possible anti-inflammatory effects.,0
Mild improvement has occurred after 5 months' treatment with tetrabenazine despite the long duration of dystonia and the presence of secondary structural changes.,0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.,1
Her symptoms and elevation of pancreatic enzymes did not respond to conventional medical treatment of pancreatitis for 18 d.,0
We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.,1
"In a series of 104 cases of intentional or inadvertent use of zidovudine at differing gestations in pregnancy, there were eight spontaneous first trimester abortions, eight therapeutic terminations, and eight cases of fetal abnormality occurring among a total of 88 cases where the pregnancy progressed.",1
The subject developed fever and peripheral blood neutrophilia.,0
"Although the precise etiology is unknown, the Epstein-Barr virus and immunosuppressive agents appear to he risk factors.",0
"Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.",1
Magnetic resonance imaging was more useful than computed tomography in the early diagnosis and management of these acute lymphocytic leukemia patients with leukoencephalopathy.,0
Topical thiotepa treatment for recurrent corneal haze after photorefractive keratectomy.,0
"No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.",1
Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.,1
"Data derives from a qualitative interview study and a cross-sectional survey of 518 patients, with all patients receiving out-patient cancer chemotherapy in Sweden.",0
"We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.",1
A 57-year-old man developed morphea while taking bromocriptine.,1
Angio-oedema as an unusual tolerable side effect of voriconazole therapy.,1
"As NBD-Cl has not been reported as an allergen before, the characteristics of this chemical and its use as an analytical reagent are briefly surveyed.",0
The two children who had severe myelotoxicity achieved the largest AUC values per milligram per square meter of 6MP.,0
Salmon calcitonin in the treatment of post herpetic neuralgia.,0
Dose and a hypersensitivity reaction were doubtful factors in these cases.,0
A young woman with epilepsy had tonic-clonic seizures during antineoplastic therapy with adriamycin and cisplatin.,1
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).,1
Neuroleptic malignant syndrome during abrupt reduction of neuroleptic treatment.,0
Pediatric heparin-induced thrombocytopenia: management with Danaparoid (orgaran).,1
Acute renal failure most likely was secondary to the nephrotoxic effect of captopril on chronically hypoperfused kidneys.,1
"He developed an inferior corneal epithelial defect and, later, a well-demarcated area of inferior corneal keratinization.",0
Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.,1
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.,1
Treatment of the chorea led to rapid resolution of her psychiatric symptoms.,0
Possible etiologic factors are traumatic osseous lesions and transport of rectal bacteria to the periosseous region.,0
Acute myocardial infarction associated with systemic lupus erythematosus documented by coronary arteriograms.,0
"Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.",1
Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma.,1
"We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.",1
"An early gestational insult, rather than a mutation, may be one cause of this heterogenous disorder.",0
After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.,1
Intrahepatic cholestasis and sicca complex after thiabendazole.,1
The clinical features and management of this combined intoxication are discussed.,0
Hemodialysis was also shown to reverse ifosfamide-related neurotoxicity.,1
"Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01).",1
"We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.",1
Serious maternal bradycardia and asystole in laboring parturients after combined spinal-epidural labor analgesia are rare.,0
Antibiotic irrigation of the capsular bag to resolve low-grade endophthalmitis.,0
This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism.,1
Mianserin (15 mg/day at 21.00 h) was discontinued and then reinstituted (off-on-off-on design).,0
This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine.,1
All patients were successfully treated with intravenous acyclovir.,0
"Other symptoms of drug hypersensitivity included nausea, vomiting, urticarial rash, and leukopenia.",0
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
A 15-month-old girl with rhinopharyngitis was treated with a nasal solution containing the imidazoline derivative naphazoline.,0
The blocked catheter was surgically explanted and the firm material inside was analyzed.,0
"After discontinuation of the 5-fluorocytosine and amphotericin B and treatment with cephradine and ketoconazole, the toxic epidermal necrolysis resolved.",0
We suggest the use of trihexyphenidyl in combination with isoprinosine in patients with subacute sclerosing panencephalitis with myoclonic seizures refractory to valproic acid.,0
Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.,1
"The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.",1
We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).,1
"A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.",1
"However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.",1
RESULTS: A previously healthy 42-year-old woman presented with acute-onset delirium with psychotic features as a consequence of levofloxacin therapy.,1
"Our cases include a 35-year-old woman with (sub)fulminant hepatitis, a 67-year-old woman with macronodular cirrhosis, and a 68-year-old man with severe chronic active hepatitis and cirrhosis, with positivity of anti-smooth muscle antibodies.",0
"By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.",1
"We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.",1
"In all except two patients, serum Na+ returned to normal values within 3 to 12 months of continued lorcainide therapy.",0
A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis.,1
"In conclusion, this case is instructive, because the symptoms which developed after a short period of corticosteroid inhalation suggested a type I allergy.",0
Protamine-induced fatal anaphylaxis.,1
"These changes resemble lymphocytic bronchiolitis in lung transplant recipients, which was well correlated with HRCT findings.",0
"A study of in vitro reactivity to L-T4, as assessed by peripheral blood lymphocyte transformation, was carried out in a patient with Hashimoto's disease who developed leukopenia during treatment with L-T4.",1
She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.,1
Significance of subclinical entrapment of nerves in lead neuropathy.,0
"We present a case of HUS in an advanced ovarian cancer patient treated with carboplatin and gemcitabine, and described its favorable outcome after chemotherapy interruption and supportive care with a 1 year follow-up.",1
METHODS: The medical records of 8 neonates treated with rFVIIa (100 micro g/kg) were retrospectively reviewed for the course of hemorrhage and the hemostatic interventions performed before and up to 24 hours after the administration rFVIIa.,0
The results of a histopathological examination of the renal biopsy specimen were unremarkable.,0
Clinical improvement occurred with cessation of the benzodiazepines and the EEG showed a return to normal patterns.,0
DISCUSSION: Opioid dependence is generally considered synonymous with heroin dependence or dependence on prescribed opioid analgesics.,0
Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).,1
After abstinence from oolong tea his delirium resolved.,1
These cases demonstrate that CBZ can induce simple motor tics in children.,1
Piritrexim-induced pulmonary toxicity.,1
Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity.,1
The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.,1
Management and successful desensitization in methotrexate-induced anaphylaxis.,1
"Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.",1
"Urgent surgical decompression was performed, showing an epidural hematoma.",0
A case of drug-induced hypersensitivity syndrome showing transient immunosuppression before viral reactivation during treatment for pemphigus foliaceus.,0
"Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.",1
"A rapidly progressive, fatal recrudescence of pulmonary Kaposi sarcoma developed in an HIV-infected man who was receiving corticosteroids for treatment of an immune reconstitution syndrome secondary to Mycobacterium avium complex pulmonary infection.",0
"Hepatotoxicity seen with erlotinib, a small molecule tyrosine kinase inhibitor to EGFR, is usually transient with mild elevation of transaminases.",0
CONCLUSIONS: Herpes zoster reactivation may occur following LASIK.,0
Salicylate-induced hepatotoxicity is reviewed.,1
"Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.",1
Three diabetic cases of acute dizziness due to initial administration of voglibose.,1
"Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.",1
"The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.",1
Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin.,1
Cisapride for the treatment of nausea produced by selective serotonin reuptake inhibitors.,0
"In conclusion, although APOLT showed clinical and laboratory improvement for some period in this patient, the final fatal outcome suggests that liver transplantation should be cautiously applied to patients with HUS associated with FH deficiency.",0
Fifteen shots of 0.06 mJ were needed.,0
These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.,1
At 24 months of age the infant's neurodevelopment was normal.,0
HIV1 and HIV2 serology was negative.,0
"Assessment of cortisol response was by insulin-induced hypoglycaemia in three cases, by short tetracosactrin test in two, and by low-dose tetracosactrin and 24-hour urinary cortisol/creatinine ratio in one.",1
CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.,1
Serum samples were collected throughout the infectious process for viral DNA analysis.,0
Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.,1
Unusual coronary artery aneurysm and acute myocardial infarction in a middle-aged man with systemic lupus erythematosus.,0
Optic nerve sheath fenestration for a reversible optic neuropathy in radiation oncology.,0
Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine.,1
CONCLUSIONS: Physicians should be aware that drug-induced AIN can be associated with proton-pump inhibitors.,0
"Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.",1
Two had positive antihistone antibodies.,0
Careful pretreatment screening and rigorous monitoring patients are recommended to help prevent this life-threatening event.,0
A 53-year-old female was admitted to hospital one hour after taking an overdose of 60 g of paracetamol and 960 mg of codeine.,0
Pseudomonas corneal ulcer after use of extended-wear rigid gas-permeable contact lens.,0
No adverse effects were noted from either vancomycin or hemodiafiltration.,0
A case of subepidermal autoimmune blistering disease in an 86-year-old woman is reported.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
Small cell carcinoma of the lung is the tumor most commonly associated with ectopic ACTH production and hypercortisolism.,0
The American Society for Regional Anesthesia and Pain Medicine has specific guidelines for treatment of these patients when they undergo neuraxial anesthetic procedures.,0
Atypical neuroleptic malignant syndrome associated with olanzapine.,1
"Importantly, this was the first time that information became available about the effects of tamoxifen in healthy women, that is, women who did not already have breast cancer.",0
"Skin rash involved regions of the face, lower abdomen, back, buttocks and both upper thighs.",0
Three patients with major depression superimposed on chronic dysthymia were treated with phenelzine.,0
Administration of cisplatin in three patients with carboplatin hypersensitivity: is skin testing useful?,1
"The TC usually develop in the presence of secondary hyperparathyroidism or a high calcium x phosphate product, while other factors have been also occasionally implicated in their development.",0
"The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.",1
We describe two patients with rheumatoid arthritis who developed chronic inflammatory demyelinating polyneuropathy (CIDP) during their course of therapy with TNF-alpha antagonists.,0
"We report a 61-year-old woman who suffered from an acute cerebral infarction during diagnostic cardiac catheterization for unstable angina, which manifested as sudden onset of global aphasia, right hemiplegia and gaze preponderance to the left side.",0
"After identification of the index patient, additional inquiry revealed that the patient's mother was hospitalized previously for overwhelming sepsis associated with metamizole use.",1
We suspect that a similar immunological pathway played a role in the pathogenesis of AGEP appearing in psoriasis and ulcerative colitis.,0
We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.,1
"Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.",1
"Malignant myelosclerosis or acute myelofibrosis is a rare acute myeloproliferative disorder characterized by pancytopenia, myeloblastosis and marrow fibrosis.",0
"Clinical evidence of vena cava thrombosis and associated spontaneous intraventricular hemorrhage developed on Day 24 and 36, respectively, and these findings were confirmed on imaging studies.",0
"We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.",1
"After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.",1
Juvenile absence epilepsy exacerbated by valproic acid.,1
"The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.",1
Agranulocytosis and granulocytopenia associated with quetiapine.,1
BACKGROUND: An infusion of prostaglandin E1 is widely used to maintain patency of the ductus arteriosus in neonates with congenital heart disease.,0
A case of liver damage following treatment with Danazol for fibrocystic breast disease is reported.,1
"Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.",1
"The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.",1
We presented a patient with status asthmaticus treated with a combination of theophylline and prednisone who developed a perforated gastric ulcer.,1
"RESULTS: The estimated number of Accutane prescriptions for reproductive-aged women has more than doubled in the past 10 years; it is the most widely used teratogenic drug in the United States, with approximately 2.5 per 1,000 reproductive-aged women exposed to Accutane in 1999.",1
"CONCLUSION: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin.",1
Acquired internal mammary artery to pulmonary artery fistula following bypass surgery.,0
"Before receiving PUVA therapy one patient had been treated with topically applied thiotepa and x-ray irradiation, while in the other patient PUVA was the only treatment received except for topical corticosteroids.",0
"An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.",1
"Clinicians should be aware that an erythematous and exfoliative rash may be induced by temozolomide, and be familiar with the pharmacologic and supportive measures necessary for its treatment.",1
She had taken feedings through a nasogastric tube with 1000 ml (1000 kcal) of Ensureliquid daily since 1993 because of the muscle weakness after rhabdomyolysis.,0
Safety of thrombolysis during cardiopulmonary resuscitation.,0
"PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.",1
Angioedema is more common in females and in the third decade of life.,0
Suspected inappropriate secretion of antidiuretic hormone in a male with mental retardation.,0
The reaction subsided after treatment with diphenhydramine and dexamethasone.,0
"Alopecia, nausea, and vomiting were attributed to the cyclophosphamide component of the therapy.",1
"We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.",1
"In the third child, the tics ceased after CBZ discontinuation.",1
Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.,1
Pegylated interferon alfa-2b is a formulation of recombinant human interferon conjugated with polyethylene glycol.,0
A treatment attempt with allopurinol was initiated while antiviral therapy was continued and was successfully completed after 6 months.,0
This case describes fulminant hepatic failure in a patient taking disulfiram with no previous liver disease and report of being compliant with alcohol abstinence.,1
The diagnosis of ELP was made.,0
Symptomatic cluster headache related to ocular pathologies have been rarely described.,0
"When prescribing mannitol to decrease intraocular pressure, the physician must be alert to potential complications.",0
These observations are consistent with the hypothesis that angiotensin-converting enzyme inhibition may cause anemia by increasing renal blood flow and consequently decreasing erythropoietin levels.,0
"We concluded that HLH, a rare but often fatal condition characterized by excessive activation of lymphocytes and macrophages, is a diagnostic and therapeutic challenge in solid-organ transplanted patients and must be suspected in the presence of fever, blood cytopenia and liver dysfunction.",0
"In order for him to receive the needed chemotherapy, we developed a desensitization protocol that was administered in the intensive care unit.",0
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy.,0
All target symptoms disappeared in the patients after an average of (mean+/-S.D.) 24.5+/-18.1 days.,0
"Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache.",1
"Foscarnet resistance and cidofovir resistance have also been described, but no previous reports have suggested treatment regimens for patients with CMV refractory to all three of these drugs.",0
Concentrations of brompheniramine and dextromethorphan were measured in both postmortem blood and liver specimens using a gas chromatograph equipped with a nitrogen-phosphorus detector.,0
A 60-year-old male patient with ischemic cardiomyopathy experienced an electrical storm 1 month after implantation of an internal cardioverter-defibrillator.,0
Adjuvant chemotherapy was not indicated and anastrozole hormonotherapy was started.,0
PURPOSE: Differential diagnosis of maculopathies can be difficult but is important if patients also suffer from other diseases such as breast cancer treated with antiestrogens.,0
Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient's development of hepatotoxicity and the TMP-SMX therapy.,1
Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.,1
"RESULTS: We recently experienced a case of fatal erlotinib-induced ILD, diagnosed based on clinical and radiologic findings, which occurred in a patient with radiation fibrosis.",1
Recent trends in the treatment of acute paracetamol poisoning are mentioned.,0
Results are discussed in light of the existing literature.,0
G-CSF was successful in producing a rise in neutrophil count which coincided with a resolution of fever; there was no adverse effect on renal function.,0
"Remarkable findings on initial examination were facial grimacing, flexure posturing of both upper extremities, and 7-mm, reactive pupils.",0
The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis.,1
Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.,1
The patient recovered and the vagina mucosa healed within two weeks.,0
We describe a 5-month-old infant who had fever of unknown origin leading to an exhaustive evaluation during a 7-week period.,0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
"A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.",1
Patients should be injury advised to seek prompt ophthalmic consultation after LASIK.,0
Both serum hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (HBsAb) were negative on admission.,0
Retinal artery embolization during carotid angioplasty and carotid artery stenting: case report.,0
Food and Drug Administration in 1989 for treatment of severely ill schizophrenic patients.,0
"Because the efficacy of the prophylactic use of lamivudine has been reported and the steroid enhances curability of malignant lymphoma, the steroid containing regimen with prophylaxis of lamivudine should be evaluated further.",0
Fulminant hepatic failure is a rare complication of disulfiram treatment for alcoholism.,1
"A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",1
This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.,1
Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.,1
We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.,1
Cerebral and ocular toxicity induced by desferrioxamine.,1
MEASUREMENTS AND MAIN RESULTS: Extensive noncardiogenic pulmonary edema.,0
"Catecholamine-induced automaticity was one of the possible mechanisms of VT in the first case, but the mechanism is unknown in the second case.",0
Isoniazid causing breast tissue enlargement has been very rarely reported.,1
All symptoms resolved with drug withdrawal.,0
"Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.",1
In May of 1997 a drug inadvertently injected intrathecally caused severe neurological damage and death to a child.,0
Can roxithromycin and betamethasone induce acute pancreatitis? A case report.,1
Clinical and laboratory manifestations resolved after cessation of methysergide therapy.,0
"Despite the severity of their illness, all patients but one survived.",0
Phenytoin levels were measured and found to be grossly elevated at 170 mmol/L.,0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
His inhibitor was increased from 15 to 580 BU within the first 4 weeks of immune tolerance.,0
"The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.",1
We do not know why these differences occur.,0
"With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.",1
These nail changes gradually disappeared when the dose of clofazimine was reduced.,1
A total of 311 patients (35.5%) had at least one small intestinal resection.,0
"Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.",1
"METHODS: A 20-year-old woman developed pain, redness, decreased vision, and corneal infiltrate in the right eye 15 days after bilateral LASIK.",0
They also raise issues of patient education for self medication and access to emergency dental services outside normal working hours.,0
A hypertensive women was treated throughout pregnancy with propranolol 40 mg daily without complication.,0
In one case the growth rate and cortisol response returned to normal 9 months after the fluticasone dose was reduced to 500 micrograms/day.,0
"Lithium may help correct a chemical imbalance in the brain; however, it has a comparatively narrow therapeutic index.",0
"After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.",1
CONCLUSION: A patient with CHF and ESRD developed myoclonic muscle spasms after receiving dobutamine by continuous i.v. infusion.,1
Treatment of atenolol overdose in a patient with renal failure using serial hemodialysis and hemoperfusion and associated echocardiographic findings.,0
Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.,1
Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.,1
This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk.,0
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
Syncope in a 65-year-old woman after nitrate ingestion.,1
The presentation can be varied depending on severity.,0
The gynecomastia regressed when the theophylline was discontinued.,1
Clinico-pathological correlations were made.,0
"Therefore, angiotensin-converting enzyme (ACE) inhibitors would appear to be appropriate therapy for hypertension in such patients.",0
"A patient with idiopathic thrombocytopenia purpura who was treated with high dosage corticosteroids for ten years, developed 18 separate lesions of avascular necrosis in 12 different bones.",0
Loperamide poisoning in the dog.,1
Clofibrate-induced myopathy in patients with diabetes insipidus.,1
"Upon subsequent reduction and discontinuation of phenobarbital, however, chlorpromazine was able to be reduced with no increase in target behaviors.",0
METHODS: The records of all five diabetic aircrew were reviewed.,0
The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.,1
Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.,1
"When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.",1
"In addition, the possible association between these features and long-term IGF-I treatment is discussed.",0
A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.,1
The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.,1
We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.,1
"Treatment with volume expansion, hypertonic sodium bicarbonate, inotropic support with norepinephrine and insertion of an intra-aortic balloon pump led to complete recovery after 72 hours.",0
The course of this rare case is described and the literature reviewed.,0
Marked elevation of serum creatine kinase associated with olanzapine therapy.,1
Treatment of lithium tremor with metoprolol.,1
Acute dystonic reaction with low-dose pimozide.,1
"Sequencing of the mitochondrial polymerase gamma gene (POLG1) revealed four heterozygous substitutions, two of which have been identified in cases of Alpers-Huttenlocher disease.",0
Disseminated fusariosis.,0
The aim was to determine the source of the recurrent lesion based on its morphology and the patient's verbal history.,0
"Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.",1
"The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure.",1
Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.,1
Spontaneous compartment syndrome in a patient with diabetes insipidus.,0
There are few reports in the literature of hypoglycemia with concurrent administration of an oral hyperglycemic agent and a fluoroquinolone antibiotic.,0
"BACKGROUND: Orbital cellulitis after strabismus surgery is uncommon, may cause blindness and may lead to death.",0
All received tissue plasminogen activator.,0
"Hiccupping is a characteristic noise caused by a sudden closure of the glottis after repeated, involuntary, spasmodic contraction of the respiratory muscles.",0
This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.,1
All-trans-retinoic acid (ATRA) is considered the recommended induction treatment for acute promyelocytic leukemia (APL).,0
"A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.",1
"In conclusion, the present case report illustrates a novel manifestation of chronic granulomatous disease.",0
Progressive hypoxemia mandated endotracheal intubation 1 week after rituximab administration and led to death 4 weeks after admission.,1
"The cycle of admissions was eventually broken by the intervention of a social worker, who provided structured non-medical support.",0
"Serum lithium levels fell rapidly, but the cognitive impairment associated with the delirium typically persisted for another week or two.",0
Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?,1
Vortex keratopathy associated with atovaquone.,1
Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.,1
"Here, a rare case of a patient with Type I GD who developed adenocarcinoma of the lung that was treated with chemotherapy, radiotherapy and biological agents inhibiting receptor tyrosine kinases is presented.",0
We report the development of squamous-cell carcinoma within a basal-cell epithelioma that was treated with intralesional injections of 5-FU.,1
Both patients made an uneventful recovery.,0
Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation.,0
"It is important to accurately identify these infections, and polymerase chain reaction assay using universal fungal primers offers a rapid and precise diagnostic approach.",0
"There are many challenges associated with treating invasive aspergillosis, particularly that due to A. terreus, and the early use of caspofungin should be considered.",0
Cultures became negative 10-37 days after the introduction of the drug.,0
Rosaceiform eruption induced by erlotinib.,1
Drug-induced gingival enlargement: biofilm control and surgical therapy with gallium-aluminum-arsenide (GaAlAs) diode laser-A 2-year follow-up.,0
Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.,1
"The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure.",1
"The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.",1
We suggest that patients receiving a high dose of vinblastine are at risk for the development of this syndrome.,0
Recovery occurred within 2 months with supportive treatment.,0
Gallstones and bile sludge are common side effects of octreotide therapy but rarely become symptomatic or require treatment.,1
"Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.",1
"Subsequently, the patient developed pulmonary emboli documented by angiography.",0
"Naratriptan 2.5 mg given each morning, with a second tablet allowed for breakthrough headache, at least 4 hours later, demonstrated a remarkable reduction in frequency and intensity of daily headache.",0
"Despite recent meta-analyses showing either similar rates or only slightly increased rates of stent thrombosis in patients with a drug-eluting stent, clinicians remain concerned about the risk of late stent thrombosis in these patients.",0
All of the patients manifested an increase in serum CK levels 1 to 3 months after the administration of antithyroid drugs.,0
"Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified.",1
Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.,1
Reflex vasospasm induced by the injection trauma may be etiologically involved.,0
"Five other patients with previous sensitivity to methotrexate, forcing cessation of therapy, were given weekly oral methotrexate and folinic acid every day except the day of methotrexate.",0
The clinical and hemodynamic characteristics of the patients were as follows.,0
Atypical CD8+ cutaneous T-cell lymphoma after immunomodulatory therapy.,0
He developed postural headache and severe nausea and vomiting after a diagnostic lumbar puncture.,0
"k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.",1
PURPOSE: A case of probable enoxaparin-induced hepatotoxicity is described.,1
"A new therapeutic regimen is suggested, which includes long-term antibiotics combined with an immediate modification of azathioprine therapy and early graft nephrectomy in selected cases with renal parenchymal involvement.",0
Two patients required emergent surgical procedures.,0
"CONCLUSIONS: As the elderly population and the incidence of heart disease increase in the United States, more people will probably be using heart drug therapy.",0
Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis.,1
Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.,1
Essential thrombocythemia in a dog: case report and literature review.,0
"On rare occasions, severe complications such as respiratory failure, metabolic acidosis, renal failure, coma, and death have been reported in both adults and children.",0
Only 114 cases have been reported in the literature.,0
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
"However, the patient became steroid-dependent and experienced recurrent optic neuritis during multiple attempts at tapering the steroids.",0
"This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.",1
"The other patient had one of four primary BCCs respond completely, and the remaining three respond partially.",0
A 47-year-old woman began treatment with cloxacillin due to acute cellulitis.,0
"Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.",1
"Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.",1
"CONCLUSION: Infectious retinochoroiditis is a potentially blinding complication seen after cardiac transplantation, justifying close clinical and serological surveillance or, in certain cases such as mismatched donors, anti-parasitic prophylaxis.",0
Antidepressants and myoclonus: case report.,0
PURPOSE: We report an unusual paradoxical effect of brimonidine.,1
"Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.",1
Neuropsychologic evaluation revealed global cognitive deficits; he was found to be a carrier of a PS-1 point mutation at position G206A.,0
Ten to 15% of patients treated with ifosfamide develop an encephalopathy.,1
"Catheter directed thrombolysis has been described as a treatment for large pulmonary emboli resistant to systemic therapy [Kelly P, Carroll N, Grant C, Barrett C, Kocka V.",0
OBJECTIVE: To report a case of reversible nonthrombocytopenic palpable purpura associated with metoclopramide.,1
Neurological side effects in two patients receiving gold injections for rheumatoid arthritis.,1
The vacuum-assisted wound closure technique and device (the V.A.C.) has become a widely accepted technique in the management of chronic and difficult wounds.,0
"CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.",1
"Warfarin-associated bleeding generally is considered deleterious; however, in our patient it unmasked an early stage of colon cancer and thus may have saved the patient's life.",1
Discontinuation of simvastatin and cyclosporine resulted in resolution of rhabdomyolysis and normalization of renal function.,1
"The treatment of visceral leishmaniasis (VL) may be complicated by drug toxicity or intolerance, and by drug resistance.",0
A thyroid scan performed at that time revealed a gland of normal size and texture.,0
We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.,1
"Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.",1
Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.,1
This is the first report on the use of charcoal haemoperfusion for acute poisoning in Australia.,0
Vocal cord paralysis as a consequence of peritonsillar infiltration with bupivacaine.,1
"Patient 2, a 24-month-old girl, was asymptomatic during the first days after the accident; subsequently, she started to cough and developed fever, dyspnea and chest pain.",0
"Virological tests showed significant increases of antibody titers against mumps virus and parainfluenza virus type 2, which strongly suggested that paramyxovirus infection occurred during the clinical course of DIHS.",0
"Methadone is recommended as being free of some of the neuropsychological side effects noticed with morphine, which are attributed to active metabolites.",0
Methemoglobinemia associated with dermal application of benzocaine cream in a cat.,1
Neither veno-occlusive disease nor thrombotic microangiopathy was documented.,0
The mean age of onset is around puberty and boys suffer more commonly as they are more inclined to play video games.,0
Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).,1
Treatment requires management of both the liver abscess and the infected shunt.,0
He rapidly recovered by intravenous hydrocortisone followed by oral prednisone administrations and percutaneous catheter pericardial drainage.,0
"Fatal agranulocytosis in an Indian male receiving 100mg of dapsone daily, hospitalized for mid-borderline leprosy in type I reaction with triple nerve paralysis is reported.",1
"The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.",1
Physicians should be aware of the potentially lethal side effects of dapsone.,1
Bromocriptine-induced schizophrenia.,1
Patients were monitored for adverse treatment effects.,0
Our findings suggested that the antecedent use of high-dose corticosteroids is involved in precipitating normotensive renal crisis.,0
"Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.",1
Clinicians should be alert to the possibility of these adverse effects in children treated with these drugs.,0
We present a 60-year-old woman with anal cancer and liver metastasis.,0
Marked improvement of psoriasis or arthropathy occurred in each case without side effects.,0
Methamphetamine abuse has been increasing in California and may exceed cocaine abuse in some regions.,0
Primary pneumococcal peritonitis complicated by exudative pleural effusion in an adolescent girl.,0
This case provides suggestive evidence that morphine-6-glucuronide can produce clinically significant effects in patients with mild renal insufficiency.,0
"Discontinuation of mianserin resulted in recurrence of akathisia, while full amelioration of the symptoms of akathisia was noted when mianserin was reinstituted.",0
"On arrival in the hospital 1 hour later, she complained of muscle pain and tiredness.",0
BACKGROUND: The safety of topical epinephrine (1:1000 concentration) has recently been called into question.,0
"Both had low levels of serum sodium, potassium and calcium.",0
"Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.",1
A patient with diffuse and focal cerebral dysfunction was found to have absent peripheral pulses.,0
Anti-thyroid Abs were found positive.,0
A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.,1
"Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.",1
Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.,1
Case 2: A 43-year-old male alcoholic remained completely abstinent with cyanamide treatment for 5 years and complained of general fatigue.,1
"When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.",1
The patient's condition progressively improved to full recovery.,0
"In 20 percent of affected individuals (9 percent of the total), sensory symptoms preceded the onset of the movement disorder, causing difficulty in diagnosis.",0
They are also underdiagnosed and undertreated.,0
"RESULTS: Treatment with this topical fluorinated corticosteroid produced a measurable reduction in the size of the hemangiomas, which permitted clearing of the visual axis.",0
"By contrast, the appearance of a hypercalcemia has yet to be described.",0
Therapeutic control was reestablished in both patients after therapy with the original levothyroxine product was reinstated.,0
"As a result of the inadequate levels of antihepatitis B antibodies, less than 10 IU/l in May 1998, in a high-risk patient who was frequently exposed to blood and its products, an additional booster dose was performed.",0
Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.,1
Immediate but gradual improvement followed withdrawal of amiodarone and treatment with prednisolone.,0
"A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.",1
"After treatment with dose-intensive intravenous melphalan followed by infusion of autologous growth-factor-mobilized blood stem cells, clinical evaluations and plasma cell studies were repeated at 3 and 12 months.",0
Disseminated histoplasmosis complicating bone marrow transplantation.,0
"There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine.",1
"Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.",1
"However, 4 days later the ocular pressure of the first patient increased to 22 mmHg, which led to suspension of the drug.",0
Discontinuation of simvastatin and cyclosporine resulted in resolution of rhabdomyolysis and normalization of renal function.,1
"Prolonged exposure to ART, specially ddl, can play a pathogenic role.",0
Cefuroxime-induced acute renal failure.,1
Aircrews are tested every 3 mo for HbA1c levels.,0
"We suggest, however, that the case against the drugs alone has yet to be proved.",0
"Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.",1
Bisphosphonate induced osteochemonecrosis of the jaw mimicking a tumour.,1
A whole brain irradiation was performed for 37.5Gy with a fraction size of 2.5Gy and gefitinib was replaced with erlotinib on the 5th day after radiation therapy commenced for disease progressing.,0
"BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.",1
During cytotoxic treatment of a child with leukemia we describe the longitudinal course of ionized calcium in a complex syndrome of hypocalcemia and hypoparathyroidism.,0
Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.,1
Motor neuron involvement in a patient with long-term corticosteroid administration.,0
"The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.",1
Four patients were neutropenic (less than 500/microliters).,0
"The beneficial effect of the long-acting analogue of somatostatin SMS 201-995 in the treatment of acromegaly is described in three cases, and current published experience is reviewed.",0
"We report a case of a 60-year-old woman affected by squamous lung carcinoma, who developed paroxysmal supraventricular tachycardia during cisplatin and etoposide combination chemotherapy.",1
Agitated dysphoria after late-onset loss of response to antidepressants: a case report.,0
"Despite prolonged external biliary drainage and systemic amphotericin B therapy, the fungus was not eliminated from her biliary system.",0
The duration of each infusion should be minimised and blood volume should be carefully monitored throughout.,0
Detailed postmortem examination of one patient revealed no anatomical abnormalities of the central nervous system.,0
"The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.",1
The criterion for severe infection was inpatient hospitalization.,0
Acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia: a case report.,1
CASE REPORT: A 64-year-old man was evaluated for chronic low-back pain after multiple spine surgeries.,0
The patient had ischemic brain lesions due to cardiopulmonary arrest at 39 weeks of corrected age.,0
A 53-year-old female who developed myelodysplastic syndrome (MDS) after chemotherapy for adult T-cell leukaemia (ATL) is described.,0
A patient with acute esophageal variceal bleeding developed fatal rhabdomyolysis during treatment with a continuous intravenous infusion of vasopressin.,1
"Cardiac arrest occurred in all patients, and four patients died.",0
The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.,1
"She was stabilized with prednisone, azathioprine, and tacrolimus.",0
How low can you go? Use of very low dosage of gold in patients with mucocutaneous reactions.,1
The authors describe two cases of paranoid confusional psychosis commencing 1 week after the patients' withdrawal from sympathomimetic amines.,0
"We studied a series of patients to determine the onset, visual significance, treatment, and recurrent nature of these pigmented membranes in patients who underwent surgery with silicone lens implantation.",0
"Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.",1
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.,1
The 125I-insulin binding rate was high (54%).,0
"A 10-year-old boy was diagnosed with ADHD and had received methylphenidate hydrochloride, 60 mg/day for 2 years.",0
Rapidly developing hyperglycemia during treatment with olanzapine.,1
"We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man.",1
Further studies should be encouraged to evaluate the usefulness of CITB for other patients with severe and otherwise untreatable tardive dystonia.,0
Additional PKP was performed with perioperative intravenous administration of ganciclovir.,0
The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.,1
The literature search found 12 cases of radiation recall caused by gemcitabine.,1
Cyclophosphamide can rarely cause interstitial pneumonitis and fibrosis.,1
Treatment consisted of supportive therapy and intravenous administration of methylene blue.,0
"This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.",1
It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.,1
"PURPOSE: Visually significant, pigmented cellular membranes may form on intraocular lenses after implantation.",0
Subphrenic abscess secondary to Actinomycosis meyeri and Klebsiella ozaenae following laparoscopic cholecystectomy.,0
"This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.",1
The visual loss in this patient seems to result from phenol neurotoxicity rather than mechanical compression of the intraorbital optic nerve.,1
There is evidence to suggest that perfusion treatment is even superior to amputation as regards survival; if so an immunological mechanism might be responsible for this effect.,0
Despite withdrawal of antiretroviral therapy a proximal myopathy developed.,0
Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.,1
Neurotoxicity of intrathecal administration of amphotericin B.,1
Four years after transplantation the patient was admitted again due to sudden worsening of New York Heart Association functional class and extreme fatigue.,0
The mortality rate is as high as 21-48% according to a recent review.,0
"In the seven patients, the mean plasma concentration of carbamazepine, but not of carbamazepine-10,11-epoxide, after clarithromycin coadministration was significantly (p < 0.01) higher than those at 1 and 4 weeks after its discontinuation.",0
Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.,1
The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor.,1
Pancytopenia is already present in GD patients and it is reasonable to expect an increased risk of hematological toxicity in treating solid tumors in these patients.,0
Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions.,1
"We describe a case of endocarditis due to Lactococcus cremoris associated with cheese consumption, that caused multiple mycotic aneurysms.",0
"Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.",1
We describe the case of a 36 year old patient who was admitted to the intensive care unit (ICU) for an acute asthma attack that failed to respond to conventional treatment and required mechanical ventilation.,0
"Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.",1
"Symptoms include fever, chills, cough, pleuritic chest pain, dyspnea.",0
Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.,1
We describe a case of symptomatic hypophosphataemia following an intra-articular glucocorticoid injection.,0
Asthma and dental erosion.,0
Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.,1
"In one child, a second course of carbamazepine resulted in a return of the dystonia.",1
Bipolar disorders as well as recurrent major depressive episodes can be most effectively treated with electroconvulsive therapy (ECT).,0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
"A CT scan revealed an abdominopelvic abscess encompassing the detached catheter which embedded in the rectosigmoid colon, allowing direct communication to the upper vagina.",0
Sciatic nerve compression very rarely occurs bilaterally.,0
"Pramipexole is a Food and Drug Administration-approved antiparkinsonian agent, which, when used to augment antidepressants, would be considered an off-label use and should be discussed with the patient.",0
"Cholesterol embolization (CE) is a potentially serious complication associated with invasive arterial maneuvers, in which standard therapy has not been established.",0
"CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.",1
"In all cases, seizures were controlled by withdrawal of phenytoin and reduction of drug levels.",1
Barbiturate-induced submassive hepatic necrosis.,1
"A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.",1
"We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period.",1
Usefulness of antiplatelet drugs in the management of heparin-associated thrombocytopenia and thrombosis.,1
Benefit from this was limited and a course of intra-arterial urokinase was instituted.,0
Herpes simplex following intra-articular sacroiliac corticosteroid injection.,0
"In patients with cirrhosis, the metabolism of meperidine is decreased, leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy.",1
Dramatic clinical improvement occurred in 2 patients treated with high dose steroids.,0
The transmethylation reaction is essential to DNA synthesis and to the maintenance of the myelin sheath by the methylation of myelin basic protein.,0
Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection.,1
The relevant literature is reviewed and supports the claim that the lithium ion may be nephrotoxic.,0
Interstitial granulomatous dermatitis associated with darifenacin.,1
RESULTS: Four patients had high intraocular pressure after intravitreal ranibizumab 0.5 mg.,0
We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.,1
"In contrast to two other reported cases, our patient was not overtly immunosuppressed.",0
Vitamin D toxicity is associated with enhanced resorption of bone in some patients.,0
"We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.",1
Where over-usage occurs a state of diminished airways response seems to result: it is also possible that the convulsions which occurred in one case may be related to such abuse.,0
Cultures of the anterior chamber were positive for Candida glabrata.,0
"Bone marrow cytogenetic study confirmed the deletion of the long arm of chromosome 11, as reported in myeloid leukemia.",0
Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.,1
"Although there is a presumed drug-drug interaction between itraconazole and nonnucleoside reverse-transcriptase inhibitors, the medical literature lacks such documentation.",0
"In order to evaluate whether this rise in lactate could have occurred without requiring additional net lactic acid production, the effect of the hydrogen ion concentration on lactate distribution was evaluated.",0
CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.,1
The symptoms and biochemical abnormality improved after gradual discontinuation of carbamazepine.,0
We report 5 cases of acute reversible renal failure coinciding with the onset of treatment with captopril in patients with severe drug-resistant hypertension.,1
"She was then treated by surgical excision of the infected tissues and by antibiotics: Amoxicillin, Metronidazole and Gentamycin for one month.",0
"Nephropathy, eosinophilia and fever were observed in an 18-year-old man being treated for staphylococcal septicemia.",0
Successful management of supraventricular tachycardia has been maintained in the 10 remaining patients for 15 to 36 months (average 26.4).,0
"A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.",1
"She was treated by right axillo-femoral bypass, removal of the aortic prosthesis and direct aortic suture.",0
"Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.",1
Paraspinal muscle impingement causing acute Brown-Sequard syndrome after posterior cervical decompression.,0
The patient recovered completely with oral prednisolone.,0
The serum immunoglobulin level returned to the normal range after the prednisolone was tapered off.,0
MR findings in methotrexate-induced CNS abnormalities.,1
We report a case of baclofen withdrawal syndrome resulting from oral baclofen underdosing.,1
"METHODS: We present a detailed case report, review the related literature, and suggest the need for prospective studies to determine the appropriate intervention in critically ill patients with pseudo-Cushing's syndrome.",0
3 of the 5 previously untreated patients achieved biochemical and bone-marrow complete remissions.,0
A 64-year-old man with schizophrenia developed myoclonic jerks when given higher doses of quetiapine.,1
"We describe a 25-year-old, human immunodeficiency virus (HIV)--negative man, who was started on antituberculosis treatment (ATT) with isoniazid (H), rifampicin (R), pyrazinamide (Z) and ethambutol (E) in the combination RHZE for the first two months and RH there on.",0
"On the first day of the schedule, moderate high doses of Methotrexate, Etoposide and Cyclophosphamide were administered.",0
Wilms' tumor with transient dermolysis of the newborn: recurrence of skin lesions during chemotherapy.,0
Due to the severity of the disease it was necessary to treat this patient with corticosteroids and immunosuppressors.,0
"We report a 45-year-old Chinese man with CML and chronic hepatitis B virus infection, on imatinib treatment, presenting with herpetic rash and acute liver failure.",1
"We hypothesize that during interferon therapy, melanocytes may produce more melanin pigment in the presence of alpha-melanocyte stimulating hormone and sufficient amounts of tyrosine, leading to melanin deposits and clinical hyperpigmentation.",0
A less well known phenomenon is paradoxical seizures.,0
"Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.",1
Gabapentin may act directly upon temperature regulatory centers.,0
Acute renal failure during lisinopril and losartan therapy for proteinuria.,1
He developed a late secondary infection in some sites treated with imiquimod.,1
We describe two patients with Boerhaave's syndrome who presented with chest pain mimicking cardiac pain and received heparin therapy.,0
"Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.",1
"After implementation of additional preventative safeguards, no further errors or complications have occurred.",0
We studied the effect of ramipril on urinary protein excretion and arterial pressure in a 27-year-old patient with GSD Ia and heavy proteinuria (2-3 g /24 h).,0
Lithium intoxication: a report of two cases.,0
"Following a closed mitral valvotomy, she received quinidine, 1.2 g/day, without interruption for 17 years.",0
The valid risk factor for developing retinopathy is hypertension.,0
Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine.,1
"3,4-Diaminopyridine (3,4-DAP) given alone or combined with pyridostigmine is the recommended basic therapy in the Lambert-Eaton myasthenic syndrome (LEMS).",0
"After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.",1
"Plasmapheresis was discontinued, and intravenous ganciclovir was initiated.",0
Nephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapy.,1
DISCUSSION: Electrolyte disorders associated with foscarnet are reviewed.,1
OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.,1
Systemic allergic reactions to aprotinin injection around the Achilles tendon.,0
We herein described an additional patient with BCR-ABL (ela2) positive acute lymphoblastic leukemia who developed tumor lysis syndrome after 10-day treatment with imatinib.,1
This report encourages the institution of HAART once the liver graft regains normal function.,0
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
"Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.",1
Tegaserod-associated ischemic colitis.,1
One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.,1
"Infections after tooth extraction and fracture of the sclerotic bone following mild trauma are serious complications, as these ordinarily common problems are very difficult to treat in such patients.",0
The two cases described in this paper are the only known deaths due to anaphylaxis.,0
"Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).",1
Valproate-induced hyperammonemia as a cause of altered mental status.,1
Liver biopsy was consistent with a drug-induced intrahepatic cholestatic reaction.,0
"It is suggested that, when drug induced pneumonitis is noted, careful screening of left ventricular function should be performed in order to diagnose myocardial fibrosis and subsequent cardiac failure.",0
Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.,1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
"Despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation.",0
"In this study, we outline the case of a patient with Stenotrophomonas maltophilia bacteremia after living donor liver transplantation, which showed the clinical signs of severe sepsis and was resistant to almost all antibiotics.",0
"Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.",1
Serial computed tomographic scans of the brain disclosed this uncommon phenomenon.,0
"Protamine sulphate 50 mg was given i.v., resulting in cessation of bleeding and normalization of the thrombelastogram and KCT.",0
"However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.",1
1). There was no involvement of other intertriginous sites and there were no associated systemic symptoms.,0
Generalised cutaneous rash associated with ganciclovir therapy has rarely been reported in literature.,1
"In contrast, a partial recovery of the Arden ratio of the EOG to 1.8 in both eyes was seen.",0
We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome.,1
"A 21-year-old woman suffering from bipolar affective disorder developed systemic lupus erythematosus (SLE) with characteristic laboratory findings, 18 months after starting carbamazepine maintenance treatment.",1
"In both cases propofol was used in bolus doses, and is thought to be the probable factor for its development.",0
Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.,1
"It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.",1
"After 3 months of pharmacological wash out, patient become pregnant and manifested this severe malformation.",0
With the immunocompromised patient it is important to seek early ophthalmologic consultation when even minor ocular symptoms develop.,0
ACE-inhibitors-induced metabolic acidosis in a child with nephrotic syndrome.,0
Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism.,0
Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C.,1
A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.,1
Coexistence of chronic myelogenous leukemia and chronic lymphocytic leukemia.,0
"Eight patients had elevated alkaline phosphatase, 4 elevated IgG and one elevated IgA.",0
"However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.",1
"The child was referred to the Hippokration General Hospital, Thessaloniki, Greece hospital with steroid-resistant NS; renal biopsy was performed, which did not show any remarkable findings and cyclosporine was administered in addition to steroid therapy.",0
Cyproterone acetate (CPA) is a widely used drug in the treatment of advanced prostatic carcinoma.,0
METHODS: Cases were identified by using a questionnaire sent to nephrologists and pathologists in French university and general hospitals.,0
"UFT has been used in Japan, other Asian countries, South America, and Russia.",0
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.,1
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
Prompt resolution of her jaundice followed the initiation of methionine therapy.,0
"We describe the case of a 20-year-old Caucasian male affected by enteropathic (Crohn's disease) spondyloarthropathy HLA B27 negative, successfully treated with infliximab.",0
"Dementia with Lewy bodies (DLB) has been associated with important behavioural disturbances, such as psychotic symptoms.",0
This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.,1
No further deterioration in the systemic disease occurred.,0
"Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine ""hypersensitivity."" When schistocytes are present it is frequently termed ""quinine-associated TTP/HUS."" A severe deficiency of the vWF-cleaving protease, ADAMTS13, is associated with idiopathic TTP.",1
Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.,1
"We report a 5-year-old boy with CF who had a stricture of the hepatic flexure region with associated narrowing due to submucosal fibrosis of the transverse colon, secondary to high-lipase pancreatin therapy.",1
"Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with ""familial seizure disorders"" may in fact have the long QT interval syndrome.",1
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
"However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.",1
Concomitant aspiration of gastric acid was thought to be the explanation for the severity of these cases.,0
"Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.",1
"In three patients who stopped this medication of their own accord, pancreatic stones re-increased or reappeared about 6 months later.",0
Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.,1
A severe lidocaine intoxication by cutaneous absorption is described.,0
Systemic allergic contact dermatitis to 8-methoxypsoralen (8-MOP).,1
Supravenous hyperpigmentation in association with CHOP chemotherapy of a CD30 (Ki-1)-positive anaplastic large-cell lymphoma.,1
"They achieved a complete remission confirmed by light microscopy, but reverse transcriptase polymerase chain reaction remained positive after ATRA, underlining the need of further chemotherapy.",0
Adverse effects of combined propranolol and chlorpromazine therapy.,0
"CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age.",1
Use of haloperidol infusions to control delirium in critically ill adults.,0
"Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.",1
The symptoms disappeared with clemastine and betametasone treatment.,0
"Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation cannot be fully ruled out, the sudden onset, prominent magnitude, and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event, possibly related to a transient coronary vasoconstriction induced by the dopamine infusion.",1
Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.,1
A greater than 50% decrease in red cell transfusion requirement was observed in one patient with RA and one patient with AA.,0
Death ensued 3 days after the onset of the rash.,0
Our present study demonstrates the utility of monitoring auditory function at frequencies higher than conventionally tested in patients receiving cis-platinum.,0
Thrombosis of mechanical valve prosthesis: thrombolysis vs surgical treatment.,0
Anaphylaxis after the injection of chymopapain occurs in about 1% of such cases.,1
"Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.",1
Thirteen consecutive stage II breast cancer patients were treated with long-term adjuvant chemotherapy using chlorambucil.,0
In vitro studies using 3H-thymidine uptake and dual parameter flow-cytometric analysis of DNA and proliferating cell nuclear antigen showed that leukemic blast cells in S phase were increased after incubation with G-CSF.,0
The trachea was immediately intubated and the lungs ventilated with oxygen 40% for four hours.,0
"However, we recently saw two patients with renal tuberculosis treated with ethambutol in whom visual loss from toxic optic neuropathies was severe and irreversible despite careful ophthalmological monitoring and prompt discontinuation of the agent at the first sign of impaired visual function.",1
The increased interest in the use of neoadjuvant chemotherapy for patients with locally advanced or large tumors at initial presentation necessitates the recognition of sequelae of this therapy.,0
"Donepezil, an oral acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease, was given to 6 cancer pain patients having sedation related to the analgesic use of opioids.",0
Creatinine 8 days earlier was 0.9 mg/dL (79.6 micromol/L).,0
The medical examiner's report indicated death caused by fluoxetine toxicity.,1
"MANAGEMENT: Discontinuation of temozolomide, discontinuation of radiotherapy, antibiotic treatment with amoxicillin and gentamicin, and administration of atovaquone and pentamidine.",0
Tc-99m labelled anti CD 66 antigranulocyte antibody imaging for assessment of bone marrow reserve.,0
Intravenous levodopa 25 mg ameliorated his akathisia symptoms drastically.,0
"The mean age of these patients was 16 years (range 4-63), and 90 were aged 15 years or younger.",0
"The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.",1
"We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).",1
This case report illustrates the importance of early detection of drug-induced hepatotoxicity and timely drug discontinuation to prevent the need for liver transplantation.,0
We review the published data as well as the current treatment recommendations.,0
Both experts would obtain an audiogram after the acute problems are treated.,0
The evidence suggests that these deaths were the result of causes other than use of the drug.,0
"A selective association between fluoxetine and extensive, prominent eye movements in nonrapid eye movement (NREM) sleep was detected, utilizing Fisher's exact one-tailed statistic (p less than 0.00001 for each comparison).",1
She subsequently haemorrhaged into the infarcted area with residual neurological deficits.,0
"A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.",1
"Quinine and its isomer quinidine are well-known causes of iatrogenic hypoglycaemia, due to excessive insulin secretion.",1
"A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.",1
Acute respiratory distress syndrome after rituximab infusion.,1
A skin biopsy showed hydropic degeneration of keratinocytes and lymphocytic infiltrate.,0
"Initially, this reaction was thought to be a result of a drug allergy, but upon further review, we determined that it was JHR.",0
"After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.",1
Tamoxifen has been used as a chemotherapeutic agent with no serious side effects noted.,0
Clinical improvement has outlasted suppression of VIP secretion (suggesting an additional direct antisecretory action of SMS 201-995) and has occurred despite expansion of hepatic metastases.,0
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
"Methanol metabolism was effectively blocked by fomepizole even after ethanol had been eliminated, and the patient recovered 20/20 vision by day 14 with normal fundoscopy.",0
Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.,1
OVERVIEW: Diagnosis of diabetes mellitus (DM) type 1 results in medical disqualification for all military aviation duties all over the world.,0
The second is a 29-year-old man with CD in whom nodular sclerosing Hodgkin's lymphoma was diagnosed 3 weeks after infusion with infliximab.,1
"A case of acute pleuropericarditis, which occurred after apparently successful percutaneous coronary intervention (PCI) for chronic total occlusion of the right coronary artery, is reported.",0
"However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.",1
It is our experience that a good outcome is dependent on early and specific treatment.,0
Anticoagulant theraphy was started.,0
The effect of repeated exposure to specific chemicals on the initiation or progression of mycosis fungoides (MF) remains unsettled.,0
BACKGROUND: 5-fluorouracil (5-FU) targets rapidly dividing cancer cell populations.,0
We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.,1
"In these cases, the pregnancy can be protected through anticoagulation treatment, but there may be exceptions to this.",0
"The clinical manifestations, characteristic radiologic images, treatment outcome, and possible mechanisms of this late complication are presented.",0
"These concerns may be reinforced by advice in the UK product information sheet to perform LFTs before and during treatment, by high infection rates with hepatitis C virus (HCV) among injecting heroin addicts and by the frequency of abnormal LFTs in alcohol abusers.",0
A third patient developed a severe pityrias rosea-like eruption.,0
Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.,0
"Bicarbonate hemodialysis treatment should take place early in the course of management, especially in patients with severe metabolic acidosis who fail to respond to intravenous bicarbonate therapy or in whom renal failure is present.",0
We report a case of myoclonus induced by quetiapine.,1
"After 582 allogeneic bone marrow transplants, we have encountered four patients (0.7%) who developed transient unilateral or bilateral sixth nerve palsies.",0
Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.,1
The intention of this case report is to raise awareness for anyone prescribing ciprofloxacin as treatment for infected diabetic and ischemic ulcers.,0
A patient with acute changes suggesting acute hepatitis after parenteral amiodarone administration is described.,1
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
"Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.",1
We advise careful monitoring of water-electrolytic balance during sibutramine therapy.,0
This case illustrates that serious sight-threatening complications may occur after LASEK due to abuse of topical anesthetic agents.,0
"The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.",1
"New neurological symptoms developed immediately after injection, and magnetic resonance (MR) imaging demonstrated trapped air displacing the dural sac.",0
We experienced two cases of CE in patients with severe atherosclerosis whose renal function deteriorated within a few months after invasive arterial maneuvers.,0
Regional lipiodolized chemotherapy for cholangiocarcinoma associated with oral contraceptives.,0
"DATA SOURCES: Published articles, abstracts, and conference proceedings.",0
METHOD: A patient with acquired immunodeficiency syndrome (AIDS) with pulmonary Pneumocystis carinii was treated with 750 mg of atovaquone three times a day.,0
We postulate that an immune-mediated disruption of caveolar function was exacerbated by statin exposure.,0
Steroid therapy improved the airways of the other 8 patients.,0
Malignant myelosclerosis (acute myelofibrosis): report of two cases following cytotoxic chemotherapy.,0
Agranulocytosis and granulocytopenia associated with quetiapine.,1
"CONCLUSION-It is possible to prevent GH from PHT treatment by intensive dental care, correct mouth hygiene and by change of treatment of carbamazepine.",0
"The number of lymphocytes in his peripheral blood, and titres of serum total IgG and IgM and anti-desmoglein1 antibody transiently decreased just before reactivation of HHV-6, cytomegalovirus and Epstein-Barr virus.",0
This case report is the first to describe a possible interaction with glipizide.,0
"The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.",1
Treatment of antithyroid drug-induced agranulocytosis by granulocyte colony-stimulating factor: a case of primum non nocere.,0
Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.,1
Diagnosis by PCR-REA.,0
"Ocular hypertension occurred 1 month after the second ranibizumab injection in patients 1 and 3, and 1 month after the first ranibizumab in patient 2.",1
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.,1
"We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man.",1
"This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.",1
Four of the eight patients had no detectable plasma cryofibrinogen after treatment.,0
This represents the first report of nonconvulsive status epilepticus induced by ifosfamide.,1
"The initial in-hospital management of adult patients with community-acquired pneumonia can be divided into five major steps: an early recognition of the patient with presumptive pneumonia, assessment of the severity of illness, establishment of an etiologic diagnosis, supportive therapy, and decision regarding initiation of empirical therapy.",0
Cefoxitin-associated renal failure.,1
Early recognition of renal toxicity of high-dose methotrexate therapy: a case report.,1
We describe four patients with episodic bilateral vision impairment related exclusively to light exposure.,0
The role of IFN-beta in inflammatory musculoskeletal disease is unclear.,0
OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.,1
Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.,1
Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.,1
This is a clinical presentation of a 14-year-old female who had weight loss and vomiting following spinal fusion surgery.,0
The patients whose glucose control is dependent on counter-regulatory hormones should be monitored for the possibility of hypoglycemia.,0
A detailed study has been made of the five hypertensive patients who received Minoxidil in Dumfries; four have been observed for over a year.,0
"We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.",1
Intrasellar and parasellar tumors made manifest by hormonal influences of pregnancy may become more common as treatment of infertility becomes more refined and successful.,0
CONCLUSIONS: The observation that neurotoxicity developed with a delay of 24 to 48 hours after acyclovir peak serum concentrations could explain the wide range of acyclovir levels reported in similar cases.,1
Anterior chamber shallowing was noted in both patients at presentation.,0
This patient was treated with endovascular stenting of the dissections along with cessation of ergot.,0
"A presumptive diagnosis of severe bronchospasm was made, and aggressive bronchodilator therapy was instituted.",0
The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.,1
"Because high AUCs of 4-hydroxycyclophosphamide, thiotepa/tepa and carboplatin correlate with increased toxicity, the treatment risk in this obese patient was significantly increased.",0
The lung had become too stiff for the anesthetic circuit bag to be squeezed by hand.,0
The catheter had been in place for 28 months for administration of a 27 month course of intravenous cefotaxime for an unsubstantiated diagnosis of chronic Lyme disease.,0
"Microscopic examination of random colonic biopsies by two consecutive sigmoidoscopies revealed angulated crystals with a characteristic crystalline mosaic pattern on the ulcerated mucosa, which were consistent with Kayexalate crystals.",0
Aspergillus fumigatus keratitis is a rare but serious complication of LASIK surgery.,0
This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.,1
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.,1
The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.,1
"In a patient with severe renovascular hypertension, nonoliguric acute renal failure developed after she received captopril treatment.",1
An urgent EEG is essential to confirm the diagnosis.,0
"The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.",1
Verapamil in effort-induced angina pectoris in patients with normal coronary arteries.,1
"The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.",1
Severe systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapy.,1
over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.,1
The patient was placed on ethacrynic acid until she was desensitized to furosemide.,0
This regimen led to a significant and long-lasting reduction of proteinuria.,0
Propecia-associated bilateral cataract.,1
Vancomycin (14 mg/mL) was also given twice daily in 2 patients.,0
"The challenge case showed eosinophilia with 1.2 10(9)/l (z = 1.79, p = 0.04) being followed by normalization despite clozapine continuation, whereas the maximum value reached 2.1 10(9)/l in the single episode case, with consecutive normalization and uninterrupted treatment.",0
"During the past decade, NTX has been shown to be safe and effective in the treatment of pruritus associated with severe jaundice caused by severe and sometimes life-threatening cirrhosis and other liver diseases.",0
Naratriptan in the prophylaxis of transformed migraine.,0
A case of Kaposi's sarcoma following treatment of membranoproliferative glomerulonephritis and a review of the literature.,0
"Approximately 2 weeks after surgery, the patient was referred to Stanford University, with 20/400 visual acuity in the left eye and a stromal infiltrate posterior to the flap.",0
CONCLUSIONS: SD-OCT and AO detected abnormalities that correlate topographically with visual field loss from hydroxychloroquine toxicity as demonstrated by HVF 10-2 and may be useful in the detection of subclinical abnormalities that precede symptoms or objective visual field loss.,1
"Because nephrotic syndrome may be induced by IFN therapy, the IFN was stopped.",1
Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.,1
"Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.",1
Data are presented to show that atopic cataracts and steroid cataracts can be similar in appearance and cannot be distinguished from one another in many cases.,0
Visual acuity improved from finger counting or less to 20/40 or better in all cases.,0
"Histopathologically, a degenerative, inflammatory thyroiditis was evident.",0
Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa.,1
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
Myoclonus associated with continuous dobutamine infusion in a patient with end-stage renal disease.,1
"Therefore, amantadine was permanently discontinued and the cornea cleared again.",1
"Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.",1
The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.,1
Type 1 diabetes mellitus provoked by peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.,1
"We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.",1
Laboratory investigations confirmed a metabolic acidosis (pH 7.15) and hyperchloremia.,0
"Mercury sensitisation: review, relevance and a clinical report.",0
Early onset of hemophagocytic syndrome following allogeneic bone marrow transplantation.,0
"METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.",1
"A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.",1
"DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.",1
The authors describe a case of acute coronary vasospasm in a young patient undergoing thoracic laminectomy with biopsy of intramedullary tumor.,0
"The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented.",1
PURPOSE: To report the detection of cytomegalovirus (CMV) DNA in the cornea of a CMV endotheliitis patient after penetrating keratoplasty (PKP).,0
It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.,1
Hemolytic uremic syndrome following the infusion of oxaliplatin: case report.,1
"PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.",1
"After 56 months, she was free of disease and treatment-related toxicities.",0
"SCs increase during chemotherapy, were often unpredictable and led to emotional consequences.",0
"To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported.",1
Isoniazid was stopped and patient was continued on R & E till completion of the treatment up to nine months.,0
Hemolytic uremic syndrome (HUS) is a rare clinical and biological entity.,0
"There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.",1
Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).,1
Delayed neurotoxicity of intraventricular interleukin-2: a case report.,1
"Based on the history and clinical features, a diagnosis of insulin-induced lipohypertrophy was made.",1
The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.,1
First-trimester pregnancy exposure can cause major birth defects.,0
Three cases of gold-related neuropathy are reported.,1
OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.,1
We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.,1
Tardive dyskinesia induced by sulpiride.,1
Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.,1
"ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.",1
Ketanserin in the treatment of protamine-induced pulmonary hypertension.,1
"Some hiccups are associated with certain diseases or occur postsurgically, and life-restricting intractable hiccups should be treated.",0
Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).,1
"A 31-year-old, white man was admitted after sustaining a gunshot wound to the chest and mandible.",0
"To treat hepatitis B, interferon alpha was administered until the proximal muscle weakness developed.",1
The patients required admission for assessment of the severity of the overdose in addition to advice about appropriate use of analgesics and advice on access to dental care.,0
Early overanticoagulation with acenocoumarol due to a genetic polymorphism of cytochrome P450 CYP2C9.,1
We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.,1
Cyclosporin therapy in Mooren's ulcer.,0
"When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.",1
"This led to a rapid unfavorable progression of hepatitis B, which was recently acquired and subsequently evolved into a severe cholestatic and fibrosing chronic hepatitis, causing multiple end-organ failure, and ultimately, death.",0
"A patient using ziprasidone with polydipsia, seizure, hyponatremia and rhabdomyolysis.",0
Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.,1
"Elderly patients for whom nitrate has been prescribed should be warned of the occurrence of hypotension, leading to unconsciousness.",1
It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.,1
He had no organic disease likely to cause SIADH.,0
OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.,1
Two cases of toxic reaction to lithium carbonate are reported.,0
Thrombolytic therapy with tissue plasminogen activator (tPA) for acute myocardial infarction may result in major bleeding complications such as gastrointestinal or intracranial bleeding.,1
"The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.",1
Trigeminal trophic syndrome with features of oral CMV disease.,0
"Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.",1
We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).,1
"Uncommonly, erythema multiforme (EM) can develop in such patients at the port site during or soon after cranial radiation and can rapidly progress to EM major.",0
"2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis.",1
"Examinations 1 1/2 to 7 1/2 years after therapy revealed all of the patients to be within normal range for height and weight, but 3 of the 6 patients treated for 8 months or longer were in the lower range of normal.",0
"A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.",1
"A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.",1
Bilateral recurrent pneumothorax complicating chemotherapy for pulmonary metastatic breast ductal carcinoma: report of a case.,0
Gemcitabine-induced rectus abdominus radiation recall.,1
Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.,1
No other diagnostic criteria for neuroleptic malignant syndrome (NMS) were present.,0
"Six isolated reports of prenatally exposed infants with various congenital anomalies exist, but to date no specific phenotype has been delineated.",0
Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.,1
"On day 12, the patient complained of dyspnea and cough.",0
OBJECTIVE: To investigate the mechanisms involved in hypersensitivity reactions to cyclosporine and determine the feasibility of future cyclosporine use.,1
"If the facial scar is a cosmetic problem 1 year after the injury, triamcinolone injections and local massage should be considered.",0
PATIENT AND METHODS: We report on a patient suffering from metastatic rectal cancer.,0
The allopurinol hypersensitivity syndrome is a rare adverse drug reaction.,1
"Since 1979, over 30 published case reports have documented the relationship between phenylpropanolamine and stroke.",1
METHODS: An extensive review of the English medical literature through the National Library of Medicine (PUBMED) was performed to identify patients who had received or continued to receive radiation therapy while on phenytoin.,0
"Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).",1
These patients would then not experience EPS and would be more likely to continue with their medication in the long term and thus avoid relapse.,0
"We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.",1
The neurological complications may be reduced by earlier recognition and better understanding of their etiopathogenesis.,0
His fetishistic behavior was treated successfully using mirtazapine 15 mg/day.,0
A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.,1
Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.,1
"The known side effects of sibutramine, ie, hypertension and tachycardia, depend on its adrenergic and serotoninergic effects.",1
A pulmonary embolus and hepatic and renal infarcts were then found.,0
The reported risk for developing acute leukemia after treatment of ovarian cancer ranges from 21 to 175 times that of the general population with a prevalence range in treated patients of 0.8 to 2.7%.,0
"Here, we describe levofloxacin-induced delirium with psychotic features in a relatively young, otherwise healthy female.",1
"Because nephrotic syndrome may be induced by IFN therapy, the IFN was stopped.",1
"Coagulase-negative staphylococci were detected in cerebrospinal fluid (CSF), and the infection persisted even with intrathecal administration of gentamycin, and intravenous administration of vancomycin and arbekacin.",0
Changes in the parameters of oxygen metabolism in a clinical course recovering from potassium cyanide.,0
"Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.",1
"The patient appeared to be homozygous for the dibucaine resistant gene, having only 15% of normal activity in his serum.",0
Treatment included radiation to the whole brain with a boost to the tumor bed.,0
"It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.",1
"Three weeks later, diffusion abnormalities resolved, and T2-weighted studies showed increased signal intensity of prolonged T2 changes in areas of prior restricted diffusion.",0
DESIGN: A small noncomparative interventional case series.,0
"Starting dosages were 134 and 201 mg/day, and were increased to 268 mg/day in both patients.",0
The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.,1
"The electrocardiogram (ECG), which was read as normal prior to ritodrine infusion, demonstrated a type I second-degree AV block which disappeared upon discontinuation of ritodrine therapy.",1
"On rechallenge she developed severe dyspnea, cough, and wheezing 20 minutes after administration.",0
Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.,1
Expandable metallic stents have been used effectively to treat multiple nonsurgical esophageal conditions.,0
Two patients with giant atrial thrombi whose treatment involved complications are presented.,0
"The effectiveness of multidrug treatment by bleomycin, methotrexate, and cis-platinum in advanced vaginal carcinoma.",0
The exophthalmos improved dramatically within 72 hours of the withdrawal of lithium.,1
We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.,1
"This paper presents 3 sisters with Gitelman syndrome who could not tolerate magnesium supplements, and whose hypotension and polyuria were eliminated by taking 2 mg/kg/day indometacin, but who grew poorly.",0
"This report will, hopefully, save other clinicians from encountering similar complications in any of their patients.",0
The other patient presented with typical cutaneous polyarteritis nodosa which responded well to corticosteroid treatment.,0
We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).,1
"Thus, varenicline may not aid smoking cessation in patients undergoing treatment with amphetamine and amphetamine-like drugs.",0
"The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.",1
"Argatroban is hepatically cleared and may be the preferred direct thrombin inhibitor in the presence of significant renal impairment, but conversely has prolonged effects in hepatic failure.",1
We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.,1
A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).,1
CONCLUSIONS: This case series describes a clinically distinct form of interface inflammation that presents late and is associated with elevated intraocular pressure.,0
Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.,1
Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.,1
Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.,1
Citalopram: an interaction study with clomipramine in a patient heterozygous for CYP2D6 genotype.,0
Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.,1
"Two days after the start of administration of SKT, her severe pain was markedly improved.",0
Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.,1
Increased ocular pressure in two patients with narrow angle glaucoma treated with venlafaxine.,1
Pathological examination on multiple uterine sections showed the absence of residual tumor cells in the uterus.,0
The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.,1
"In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.",1
The physician should be aware of this complication before in initiating treatment with this drug.,0
Her serum calcium level was finally stabilized in the 2.37-2.95 mmol/L by administration of a single intravenous dose of pamidronate.,0
Pentacam analysis may serve as a useful adjunct in following the progression of herpetic reactivation cases.,0
"A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.",1
Acute syphilitic posterior placoid chorioretinitis following intravitreal triamcinolone acetonide injection.,1
"Multibacillary, lepromatous or borderline leprosy patients may present two types of vasculonecrotic reactions: Lucio phenomenon and that associated with erythema nodosum leprosum.",0
"Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.",1
Hyperkalemia as a late side effect of prolonged adrenocorticotropic hormone therapy for infantile spasms.,1
Required doses of Danaparoid were consistently twofold that previously reported for adults.,0
"We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate.",1
"Although lung specimens were lacking from these three patients, it is suggested that the pulmonary toxicity of CCNU may be dose-related.",1
"We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.",1
Evidence regarding the remyelinating nature of human monoclonal antibodies raises interest in the potential therapeutic role these antibodies may have.,0
Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.,1
This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.,1
Profound hypoxemia during treatment of low cardiac output after cardiopulmonary bypass.,0
We present two such case of epilepsy induced by video game.,0
"CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual ""shining,"" glare, color vision anomalies, and gradually decreased vision.",1
"The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.",1
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
Four patients remained dialysis-dependent and died within 4 weeks of presentation.,0
"After a subacromial injection with betamethasone and lidocaine, the patient noted 3 weeks of near complete pain relief, followed by a return of her symptoms.",0
Fatal liver failure following generalized tonic-clonic seizures.,0
"Orthostatic hypotension was also noted at that visit, with a standing blood pressure measurement of 95/80 mm Hg.",0
"Effective management of the transplant recipient depends on preventing excessive vasoconstriction, usually with calcium channel blocking agents.",0
"Improvement in prothrombin time, activated partial thromboplastin time, and fibrinogen after rFVIIa administration was statistically significant, as compared with that observed after conventional treatment.",0
"The diagnosis was confirmed following a single-blind, placebo-controlled provocation test with phenylbutazone and a biopsy of the affected skin.",0
Enterovirus was detected by the polymerase chain reaction (PCR) in two samples of pleural fluid that were obtained 21 days apart while he was alive.,0
We report an unusual case of thrombocytopenia associated with neuroleptic malignant syndrome (NMS).,0
Median patient age was 52 years.,0
Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.,1
Drug withdrawal and brief steroid therapy resulted in clinical remission within two months of diagnosis.,0
"The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited.",1
"We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.",1
Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.,1
Vardenafil is a new oral phosphodiesterase inhibitor used for erectile dysfunction.,0
"Heparin cessation is a vital first step in treatment; however, alternative anticoagulant therapy is essential.",0
Case report.,0
"Examination revealed confusion, jaundice, signs of chronic liver disease, portal hypertension and hepatic encephalopathy.",0
"OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.",1
Adrenal suppression in a fetus due to administration of methylprednisolone has hitherto been rarely published.,1
Desensitization to hydroxychloroquine--experience of 4 patients.,0
Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.,1
"While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug.",1
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.,1
Transcutaneous computed tomography guided core needle biopsy established the diagnosis of pelvic actinomycosis obviating immediate surgical intervention.,0
"An immunocompromised patient, 6 weeks after bone marrow transplantation, developed extensive skin infection due to Trichophyton rubrum.",0
Delusional parasitosis associated with phenelzine.,1
Inhaled drugs must be used regularly.,0
This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due to fenoprofen.,1
Chemotherapy in massively obese patients may be complicated by difficulty in calculating body surface area.,0
OBJECTIVE: Quetiapine is a recently introduced atypical antipsychotic.,0
"Discontinuation of acetazolamide produced an immediate threefold drop in the level of urinary calcium excretion and a slight rise in tubular reabsorption of phosphate, with no dectectable change in serum calcium or phosphate concentrations.",0
"A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.",1
Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.,1
Ballistic movements due to ischemic infarcts after intravenous heroin overdose: report of two cases.,1
These patients developed a debilitating photosensitivity that persisted for months to years even after they stopped taking the diuretic.,0
"A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.",1
"We concluded that leflunomide is a new immunosuppressive agent with anti-CMV activity, which may be useful in the treatment of multiresistant CMV.",0
The patient received bleomycin 189 U over five days for preoperative control of a squamous cell carcinoma of the right tongue and tonsil.,0
Amisulpride and sertraline were discontinued.,0
A 61 year-old male patient developed gynecomastia after starting theophylline.,1
"A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis.",1
The use of intrauterine Monsel's solution in severe hemorrhage after evacuation of retained products of conception: a case report.,0
"De novo hepatitis B virus (HBV) infection after orthotopic liver transplantation (OLT) always progresses to chronic hepatitis because of the patients' immunocompromised status, and only a few then acquire hepatitis B surface antigen (HBsAg) seroconversion even with efficient antiviral therapy.",0
"The patient became afebrile after 48 h, and his general condition improved within 36 h.",0
A case of congestive heart failure in a child with Wilms' tumor treated Adriamycin is presented and discussed.,1
Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.,1
Delayed-onset multifocal polymicrobial keratitis after laser in situ keratomileusis.,0
The prosthesis may be responsible for blood seeding infection and not only a mere victim.,0
"Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.",1
BACKGROUND: Pemphigus is an autoimmune blistering disease of the skin and mucous membranes.,0
"One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).",1
The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.,1
"In this patient, the recurrence of the disease, the presence of filamentous strands on electron microscopy during both bouts of hepatitis and the efficacy of ribavirin on post-transplantation hepatitis suggest that the disease was caused by an original virus.",0
This would suggest that botulinum toxin is a safe and effective first line treatment for palatal tremor.,0
"Myoclonus has been reported as a side effect of antidepressants, and the serotonin hypothesis has been advanced to include this syndrome.",0
Gabapentin-induced mood changes with hypomanic features in adults.,1
The plasma concentrations of procainamide and N-acetyl procainamide were at subtherapeutic levels.,0
Neuralgic amyotrophy associated with antibiotic therapy.,0
Useful interventional thrombolytic and anticoagulant therapy for thrombosis due to embolization (TAE) in Budd-Chiari syndrome.,0
A report of three cases and a review of the literature.,0
Blood gas analysis revealed a respiratory acidosis.,0
"However, 1 eye had vitreous hemorrhage after repeated injections of tPA.",1
A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.,1
Drug interactions between Ritonavir and Tacrolimus should be anticipated.,0
STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.,1
Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.,1
Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.,1
"Interventional pain management is an evolving field, with a primary focus on the safety of the patient.",0
Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects.,1
"Fourteen days of treatment with ganciclovir led to a prompt improvement in the symptoms of colitis, resolution of the pyrexia, normalisation of the liver function tests, and clearance of the virus, as measured by a negative cytomegalovirus DNA PCR.",0
Dapsone syndrome in cutaneous lupus erythematosus.,1
Atomoxetine has been explored as an alternative treatment as one of the few non-stimulants available to treat ADHD.,0
CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy.,1
"We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis.",1
It has been reported that these atrophic areas remain unchanged and localized lipoatrophy may be preceded by a subcutaneous panniculitis.,0
"Daptomycin is a new cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment.",0
We recommend that the immune status of these patients to varicella-zoster virus be assessed by a serum titer.,0
We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.,1
"When the dose of 0.5 mg tid was discontinued, the obsessive-compulsive symptoms resolved with no return over 8 months of follow-up.",0
Sustained monomorphic ventricular tachycardia after adenosine infusion.,1
"Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.",1
Electroconvulsive therapy in myasthenia gravis.,0
"Comparison of urinary levels of the porphyrin precursors, delta aminolevulinic acid and porphobilinogen, under controlled diet conditions before and after withdrawal of diphenylhydantoin, showed that this drug accounted for approximately one-half of the porphyrin precursor excretion.",0
Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.,1
We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.,1
"In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.",1
We describe a 15-year-old female patient diagnosed with acute lymphoblastic leukemia presenting with status epilepticus after receiving intrathecal methotrexate.,1
The study included three men and one woman aged 52-65 years.,0
Autologous bone marrow transplantation in relapsed HIV-related non-Hodgkin's lymphoma.,0
Riluzole is a new drug representing the first active treatment for amyotrophic lateral sclerosis.,0
"His blood sugar became uncontrolled, he gained 13 pounds, and his A1c increased to 9.4%.",0
We reported a case of disulfiram-induced hepatitis with unique clinical features and compared our case with others in the literature.,1
"Acrodermatitis enteropathica with SMON almost always has a high occurrence of visual impairment, but other sensory disturbances are slight or absent, while common adult SMON is just the opposite.",0
"Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.",1
"After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.",1
Coronary vasospasm resulting from a sudden autonomic response associated with an intracranial procedure was encountered during percutaneous radiofrequency trigeminal rhizotomy.,0
"Naloxone, a pure opioid antagonist, has demonstrated reversal effects from clonidine intoxication.",0
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.,1
MRI with gadolinium enhancement demonstrated prominent multifocal enhancing white matter lesions.,0
DISCUSSION: Drug hypersensitivity reactions are the most common cause of AIN.,0
Toxic hepatitis induced by disulfiram in a non-alcoholic.,1
Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.,1
Hepatolithiasis (intrahepatic stone) during octreotide therapy for acromegaly: a case report.,1
"She had previously been treated unsuccessfully with a number of atypical antipsychotic medications, before she was eventually started on clozapine.",0
"Seven of 10 patients experienced serious adverse events, which led to withdrawal of linezolid in all seven.",0
"A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.",1
Olfactory changes among patients receiving chemotherapy.,0
"Successful management was made possible by a new somatostatin analogue (Vapreotide), administered i.m. at weekly intervals.",0
It is generally well tolerated and significant adverse reactions occur rarely.,0
"We report a t(4;11)(p12;q23) with rearrangement of MLL and FRYL (also known as AF4p12), a human homolog to the furry gene of Drosophila, in an adult patient with therapy-related AML after fludarabine and rituximab therapy for small lymphocytic lymphoma and radiation therapy for breast carcinoma.",0
"Intravenous administration of 90 mg commercial serumcholinesterase, the equivalent to 1000 ml fresh human plasma, restored twitch and tetanic responses and the patient could lift his head 15 min after the beginning of the enzyme injection.",0
"In both cases, the diagnosis of PTE was based on clinical assessment of sudden acute respiratory failure with positive pulmonary perfusional scintigraphy in spite of a negative chest X-ray.",0
The biochemistry of paracetamol hepatotoxicity is outlined and the increased susceptibility of alcoholic patients to the hepatotoxic effects of paracetamol is remarked upon.,1
Repetitive paroxysms of supraventricular tachyarrhythmias triggered during pediatric cardiac interventions: suppression after short infusion of amiodarone.,0
"Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough.",0
"Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.",1
Neonates who receive prostaglandin E1 at recommended doses for more than 120 hours should be closely monitored for evidence of antral hyperplasia.,0
Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.,1
Dose-dependent olanzapine-associated leukopenia: three case reports.,1
"There have also been some spontaneous reports of serious ventricular dysrythmiasis with prolongation of the QT intervals, rarely associated with death.",0
INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.,1
This case extends the spectrum of fludarabine pulmonary toxicity to include pulmonary nodules.,1
The mean +/- SD decrease in VAS at this time was 61.2 +/- 15.5%.,0
"CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.",1
WE is usually associated with alcoholism and malnutrition.,0
Magnification revealed that these were scolices within cysticerci.,0
Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.,1
We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.,1
The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen.,1
"Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.",1
"CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.",1
"In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.",1
Gelofusine allergy--the need for identification jewellery.,1
CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.,1
"The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.",1
Hypersensitivity reactions involving the kidneys can occur with any of the penicillin groups.,0
DISCUSSION: The severity and presentation of central nervous system toxicity due to ifosfamide varies greatly and involves a spectrum ranging from subclinical electroencephalogram changes to coma.,0
RESULTS: Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.,1
"Because the patient had declined surgery, RFA was chosen for therapy.",0
RESULTS: The population consisted of 11 female and 2 male patients with RA.,0
"Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.",1
Severely elevated serum lithium levels were found.,0
Ectropion secondary to bolus injection of 5-fluorouracil.,1
"Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.",1
Bone marrow needle aspirate showed a normal trilineage differentiation.,0
Allergic contact angioedema to benzoyl peroxide.,1
The hepatic enzyme disturbances normalized after discontinuation of pegvisomant.,1
RESULTS: Two patients with ocular inflammation of unknown origin developed severe chorioretinitis after IVTA injection.,1
"Although we hope the discovery of the FMF gene will allow the diagnosis of FMF to become genetically accurate, the reality is that both clinical and genetic tools must still be used together unless mutations are identified on both of a patient's chromosomes.",0
High-dose intravenous melphalan for plasma-cell leukaemia and myeloma.,0
"As a result, one of these individuals had premature death.",0
A retrospective review of TTP patients with quinine-associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed.,1
Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.,1
The thrombus causing the liver infarction was detected as a low echoic mass by transesophageal echocardiography at the right coronary sinus.,0
A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.,1
Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.,1
"We report three young Chinese male patients who underwent aortic valve replacement for severe aortic regurgitation of subacute onset, complicated by recurrent dehiscence of the aortic valve prosthesis, due to aortitis.",0
"In patients with cirrhosis, the metabolism of meperidine is decreased, leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy.",1
"In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.",1
We describe the case of a man with dermatomyositis and stage IV nasopharyngeal cancer treated with chemoradiotherapy and s.c. amifostine.,0
"In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.",1
Myelodysplastic syndrome in a patient with adult T-cell leukaemia.,0
"Thus, troglitazone should be prescribed with caution and should not be used as a first-line agent in the treatment of type II DM when potentially less toxic alternatives are available.",0
Histological examination of the kidneys showed tubular dysgenesis with poor differentiation of the proximal tubules.,0
"A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.",1
Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.,1
We describe a patient who developed disseminated Fusarium infection with a secondary fungal endophthalmitis after an autologous bone marrow transplant for acute myeloid leukemia.,0
"Following discontinuation of clozapine, she was rechallenged and again was observed to have seizures.",1
He was treated with antibiotics and his fever went down.,0
New onset of CD may be considered as an immune-mediated injury induced by etanercept.,1
We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.,1
These results suggest that clozapine may be an effective antipsychotic agent for this subset of BPD patients.,0
"After prostate irradiation, many patients experience a transient rise in serum PSA levels and a subsequent decline without any treatment.",0
Steroid therapy predisposes to early dissemination and a potentially fatal outcome.,0
Allopurinol-associated hand and foot deformities in chronic tophaceous gout.,1
The psychotic reaction was thought to be due to steroid therapy since no other causes could explain the psychotic reaction.,0
"Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).",1
Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug.,1
This case illustrates the need for close ECG monitoring during ritodrine treatment when clinical symptoms arise.,0
"A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.",1
Conventional explanations of the decline in renal function with ACE inhibition do not account for irreversible decrements in renal function.,0
Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.,1
We suspect that isotretinoin may complete for normal retinol binding sites on cell surfaces or transport molecules.,0
The patient had been on oral propranolol for the past five years and had taken his last dose of propranolol approximately ten hours before the administration of parenteral verapamil for treatment of a supraventricular tachycardia documented by an electrocardiogram.,0
"The aim of this study is to draw attention to the adverse effects of henna, applied over the whole body, observed in glucose-6-phosphate dehydrogenase (G6PD) enzyme deficient siblings.",0
"It is considered to be an organism with a limited pathogenic potential, which is rarely capable of causing diseases in humans other than in those who are in an immunocompromised state.",0
"Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.",1
"We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.",1
"Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.",1
Septic knee arthritis after intra-articular hyaluronate injection.,1
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
There was no correlation between onset of symptoms and CyA levels.,0
"The constellation of chronic cough, dyspnea, and hemoptysis can include a broad range of differential diagnoses.",0
"NMS is a drug-related response to various medications, such as Haloperidol, which the patient was receiving.",1
CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis.,1
The incidence of seizures related to primary brain tumors is 20-80%.,0
These results indicate that CFSE dilution assay will be useful for the diagnosis and monitoring of drug hypersensitivity.,0
High-dose intravenous mannitol infusion in various clinical settings may result in acute renal failure (ARF).,1
"Treatment, mainly steroids and ciclosporin, should be aimed at the control of acute manifestations of cGVHD.",0
The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.,1
"This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.",1
We reviewed the literature on the effects of corticosteroids and chemotherapy on aaa formation and discuss possible mechanisms for drug action to promote aneurysm expansion and rupture.,0
Pulmonary oedema after hexoprenaline administration in preterm labour.,1
"Patient 1, a 21-month-old boy, started to cough and developed tachypnea, sternal retractions and mild cyanosis immediately after aspiration.",0
"However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.",1
These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.,1
Prompt hemostasis was achieved in half of the patients with their coagulation profile being restored within 4 hours after the administration of the first dose of rFVIIa.,0
The other ten were given Adriamycin without this compression.,0
"A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.",1
"To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.",1
"The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.",1
PATIENTS AND METHODS Patients with advanced PEComa were treated with sirolimus and consented to retrospective collection of data from their medical records and analysis of archival tumor specimens.,0
Candida shunt infection appears to occur by either contamination at the time of shunt placement or by hematogenous dissemination.,0
Severe hypopharyngeal dysphagia in a patient on chronic steroid treatment.,0
CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole.,1
A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.,1
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.,1
We report the case of an adult patient with acute lymphoblastic leukemia who presented with repeated transient ischemic attacks followed by a seizure during consolidation treatment with L-asparaginase.,1
"METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.",1
Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.,1
Carbamazepine was discontinued and the patient remained asymptomatic.,0
"The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.",1
The authors describe two patients with this disease who initially had findings suggestive of an optic neuropathy.,0
"To our knowledge, this is the first reported case in Thailand.",0
"Our findings may contribute to the understanding of leprosy reactions pathogenesis, broaden the knowledge about their outcome with standard treatment, and provide the scientific background to design better therapeutic strategies for these complications.",0
CONCLUSIONS: Carboplatin desensitization can be successfully performed on an outpatient basis with close observation and cardiorespiratory monitoring.,0
"Characteristic angiitis was found in the ileum with normal-like mucosa, and it was not necessarily associated with ileal ulcers.",0
Two patients are presented illustrating some differences between enteral and parenteral feedings in children receiving intensive chemotherapy.,0
"When the data of the 57 patients are evaluated, a reversible direct cytotoxic effect of ticlopidine on the pluripotent/bipotent hematopoietic progenitor stem cell is proposed.",1
Difficulty with anticoagulation may still be experienced with the newer formulations.,0
The patient had been receiving acenocoumarol 4 mg/d for 10 years for episodes of atrial fibrillation and recurrent deep venous thrombosis.,0
"This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.",1
"Histologically, these defects appear as osteoid-like niches in the developing dentin which alter the overlying enamel.",0
We describe a case of recurrent impetigo herpetiformis in an 18-year-old pregnant woman who had normal serum calcium levels and responded well to prednisolone therapy.,0
"One and a half years later, she is still alive and well, on interferon for persisting myeloma.",0
"One year later, he was readmitted to our clinic because of nonfunctioning tube and peristomal cellulites.",0
"On the next day he died, probably as a result of heart failure.",0
Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction.,1
"Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.",1
Laboratory abnormalities were initially attributed to chemotherapy toxicity.,0
"SUMMARY: Patients with NSTE ACS for whom a conservative treatment strategy is selected should receive enoxaparin, fondaparinux, or unfractionated heparin (UFH) as anticoagulant therapy.",0
"Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.",1
Two patients died.,0
OBJECTIVE: To report three cases of bilateral Acanthamoeba keratitis in association with Synergeyes hybrid contact lens wear.,0
"Patients were followed up clinically with slit-lamp examination for evidence of tumor disappearance or recurrence, and local and systemic side effects.",0
CONCLUSIONS: This treatment modality appears to provide an additional alternative for managing superficial periocular hemangiomas which threaten vision.,0
"It was postulated that the allergic reaction was most likely caused by capecitabine or the intermediate metabolites based on the immediate reappearance of symptoms from the rechallenge, pharmacokinetic data, and well-tolerance of fluorouracil.",1
"Over two-thirds of the patients treated with intravenous cimetidine demonstrated a reduction in gastrointestinal symptom severity, and a statistically significant reduction in the mean severity rating for all patients was observed.",0
We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.,1
Neurotoxicity of intrathecal methotrexate: MR imaging findings.,1
"When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.",1
"Data suggest that addition of amphetamine to varenicline may negate the partial agonism of varenicline, resulting in elimination of the smoking-cessation aid's benefits.",0
"The authors suggest that fluoxetine-induced akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission and that the pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced ""jitteriness"" may be identical.",1
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
Propranolol had to be given for eight months after surgery.,0
A case report.,0
The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.,1
Management of immunocompromised patients with diffuse pulmonary infiltrates remains a common and stubbornly difficult problems.,0
Severe autoimmune hemolytic anemia following rituximab therapy in a patient with a lymphoproliferative disorder.,1
"The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.",1
"Several different preparations are available including interferon beta 1a (Avonex, Rebif) and interferon beta 1b (Betaferon/Betaseron).",0
RESULTS: Thirteen patients had died; 1 of these died of liver failure.,0
"Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.",1
Analysis of the case which went to trial indicates that there is not one prescribed protocol which must be followed; the definition of standard of care is broader than that.,0
Numerous oral complications have been documented as a consequence of chemotherapy for the treatment of cancer.,0
Heart Vessels 2006;21:124?6].,0
"In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively.",1
"A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.",1
All patients had experienced multiple episodes of severe hypoglycaemia and had impaired awareness of hypoglycaemia.,0
"The patient received only the ophthalmic sulfonamide, and it was used for one day, but he developed Stevens-Johnson syndrome.",1
A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).,1
"After an initial excellent response, each patient relapsed and developed a severe chronic depression that was refractory to other treatments.",0
Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).,1
Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.,1
Studies performed 10 years ago on 25 patients with MTX-induced liver cirrhosis indicated that this type of cirrhosis was not of an aggressive nature.,1
BACKGROUND: Back pain is a common presentation associated with opioid seeking behaviour.,0
We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.,1
This complication occurred 14 days after the commencement of highly active antiretroviral therapy (HAART) for advanced HIV infection.,0
A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.,1
Lymphomatoid granulomatosis developed in a patient with pemphigus vulgaris who had been undergoing immunosuppressive therapy for three years.,0
"This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.",1
OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.,1
"Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis.",1
Torsade de pointes associated with moxifloxacin: a rare but potentially fatal adverse event.,1
A MEDLINE search identified all the reported cases of hypersensitivity reactions to cyclosporine.,1
We believe that immunosuppression-induced pneumonitis in a lung allograft is a serious dilemma for lung transplant physicians,0
Ticlopidine-induced marrow aplasia treated with cyclosporine.,1
Proctoscopic examination revealed a spotty mucous exudate.,0
"This regimen was well tolerated, although both children were critically ill.",0
"We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.",1
"Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.",1
Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).,1
"However, this aggressive chemotherapy has not offered any advantage because of an unacceptably high treatment-related morbidity and mortality (17%).",0
It should be emphasized that this syndrome may occur after irradiation and chemotherapy in patients with nasopharyngeal cancer.,0
"A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.",1
Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.,1
"Here, we present an angiosarcoma of the neck occurring after curative chemoradiation.",0
Propranolol-related bronchospasm in patients without history of asthma.,1
METHODS: Rituximab (1 mg/0.1 ml) was injected in the vitreous of one eye of three Dutch-belted rabbits.,0
"In contrast to other reports regarding disseminated M. genavense infection, the patient is still alive and well.",0
The case of a bipolar patient who developed thyrotoxicosis with severe exophthalmos while on lithium therapy is described.,1
"The diagnosis was based on the rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy finding, following the administration of ampicillin.",1
The psychotic behavior resolved completely soon after the discontinuation of levetiracetam.,1
Pemphigus vulgaris precipitated by glibenclamide therapy.,1
Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.,1
Microangiopathic hemolytic anemia in a patient with recurrent anal cancer and liver metastasis.,0
"Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.",1
A review of the literature suggests that this may be an unusual complication of thrombolytic therapy.,0
Amiodarone-induced dysthyroidism.,1
Broad-spectrum antibiotic therapy and percutaneous abscess drainage under the guidance of computed tomography resulted in a satisfactory resolution of the abscess.,0
"These observations have been reflected in postmarketing clinical experience, leading to recommendations that novel antipsychotics, such as sertindole, should be prescribed to first-episode patients.",0
Here we describe the case of a 69-year-old patient who achieved a second complete remission with this association without additional toxicity.,0
We describe a case of intraoperative gelatine-induced anaphylaxis whose diagnosis was delayed as the use of gelatine during surgical procedures was omitted for two times in patient's medical records.,1
"Despite this, the lesions worsened in severity.",0
"Clinical examinations and slit-lamp photographs, over an average of 21.3 +/- 7.2 months (range, 11 to 31 months), documented the effects of different treatment modalities.",0
A 62-year-old man had received perhexiline maleate for 18 months before death.,0
Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.,1
We have used the gastrinoma syndrome to examine the effects of SMS.,0
Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors.,1
"He was treated with intravenous quinidine gluconate and oral doxycycline, in addition to blood transfusion, and he responded well to the treatment.",0
"After this episode, she showed the rapid destructive stage of the Rett syndrome, i.e., severe psychomotor retardation with loss of speech, peculiar stereotypic hand movements, autistic behavior and seizures.",0
We review the literature and discuss its pathogenesis.,0
Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.,1
We describe a drug-drug interaction between itraconazole and efavirenz in a patient with disseminated histoplasmosis and acquired immunodeficiency syndrome (AIDS).,0
A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.,1
Rupture of a cerebral aneurysm associated with nifedipine treatment.,1
"DISCUSSION: Central nervous system (CNS) toxicity has been described with ifosfamide, with most cases reported in the pediatric population.",1
"The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.",1
"OBJECTIVE: Pancreatic enzyme is essential in the treatment of cystic fibrosis (CF), but intolerance to it occasionally occurs.",0
Possible causal mechanisms are discussed.,0
This pattern is suggestive of renal toxicity due to tobramycin.,1
"We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.",1
"RESULTS: Of the 74 neonates evaluated, 65 had no signs of gastric obstruction and were considered normal; 5 had clinical and radiologic or pathological evidence of gastric obstruction consistent with the presence of antral mucosal hyperplasia.",0
"Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.",1
Pursuing a diagnosis in a Caribbean man.,0
She was found to have diffuse pulmonary infiltrates on chest radiograph and a marked peripheral eosinophilia without leukocytosis.,0
These later regressed when the drug was withdrawn.,0
"Repeated exposure and rechallenge of the subject to sulindac was deemed too dangerous, and precludes exact method to establish mechanisms to explain this transient, reproducible, idiosyncratic, adverse drug reaction.",0
We report the successful treatment of Staphylococcus aureus endocarditis in a renal transplant recipient with preservation of his renal allograft.,0
A fatal case of pancytopenia due to levomepromazine.,1
Nystatin was ineffective.,0
Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.,1
CONCLUSION: Recent data suggest that eosinophils may directly damage the gastrointestinal tract wall in eosinophilic gastroenteritis.,0
The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.,1
"After administration of Oxybutynin concomitantly with an increase in the dose of Dantrolene, she presented the clinical symptoms and laboratory finding of Carbamazepine intoxication.",1
"After a latent period of 4 months, he developed a progressive, severe and ultimately fatal radiation myelopathy, which we suggest was due to a synergistic interaction between the high-dose chemotherapy and the radiotherapy.",0
Herein we present our case and a review of the literature about the systemic toxicity of PI.,0
Captopril-induced acute reversible renal failure.,1
"A variety of medications have been associated with hypoglycemia, but the list of these medications is expanding.",0
Single drug level measurements may therefore be of little diagnostic value.,0
"In our case, a 77-year-old woman, with stage IIIA IgG lambda multiple myeloma for two years, presented with firm nodular violaceous cutaneous lesions on the left arm without underlying bone osteolytic lesions or subcutaneous tumors; the biopsy was consistent with plasmacytoma.",0
A case report.,0
Massive subfascial hematoma after alteplase therapy for acute myocardial infarction.,1
Impetigo herpetiformis is a rare non-infectious pustular dermatosis of pregnancy.,0
Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.,1
Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.,1
The potential for adverse system reactions resulting from topical medications should be considered.,0
"We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.",1
CDT appears to be a useful modality in managing difficult cases of free-flap salvage.,0
We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.,1
We recently dealt with a case of severe OHS presenting features of liver dysfunction; such a case has not been reported on before.,0
"Five days postoperatively, slitlamp biomicroscopy of the left eye showed an appearance similar to haze after photorefractive keratectomy, with greater density at the center and striae convergent toward the infiltrate (stage 4 diffuse lamellar keratitis [DLK]).",0
"In two patients in whom conventional therapy failed, clotrimazole was successful in controlling recurrent infection following penetrating keratoplasty.",0
Pediatric neurosurgeons commonly instill vancomycin into the ventricles to treat shunt infections.,0
The possible development of a drug-induced vasculitis or lupus-like syndrome should be added to the list of rare toxic effects of vancomycin.,1
Perilesional linear atrophic streaks associated with intralesional corticosteroid injections in a psoriatic plaque.,0
"Hypothyroid and hyperthyroid disease are both associated with a variety of muscle abnormalities, from myalgias to myopathy.",0
"Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.",1
"We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.",1
"In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.",1
Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.,1
"Although the cardiotoxicity of 5-FU is well documented, there is little published data about cardiovascular adverse effects of Capecitabine.",0
In four patients the levels were > or = 18 times the upper limit of normal.,0
"A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.",1
"A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.",1
"Three URTI and one associated upper and LRTI were diagnosed in three BMT recipients out of six patients admitted to the BMT unit, during eight-wk period (March and April 2008).",0
The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.,1
Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.,1
"The syndrome is characterized by various gastrointestinal symptoms as well as irritability, diaphoresis and lethargy.",0
"Much of this tone reflects abnormal vascular function, characterized by impaired prostacyclin and EDRF effects, in conjunction with increased vasoconstriction due to endothelin and possibly other factors.",0
"Because new drug therapies have been developed, it is important to know the interactions between antiretroviral and antiepileptic agents.",0
We report a 67-year-old man with Parkinson's disease for 9 years who developed compulsive use of levodopa.,0
"Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.",1
"Drug-induced rhabdomyolysis is an established but rare adverse effect of high doses of cholesterol-lowering agents (statins) or interactions between drugs (eg, statins and fibrates).",0
This case illustrates the role of the *3 polymorphism of the cytochrome P450 CYP2C9 as an independent risk factor modulating the sensitivity of patients to the anticoagulant effect of acenocoumarol.,0
"In any case, from a clinical viewpoint, caution should be used when giving venlafaxine to patients with narrow-angle glaucoma, and ocular pressure must be monitored.",0
"A 27-year-old woman was admitted because of breathlessness, orthopnea, and hemoptysis.",0
Nocardia Asteroides was isolated from fine-needle aspiration material of the thyroid abscess.,0
"A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.",1
Fatal venous thrombembolism complicating imatinib therapy in a patient with metastatic gastrointestinal stromal tumor.,1
"An 18-year-old male patient was under treatment with infliximab at a dose of 5 mg/kg at Weeks 0, 2 and 6 for refractory Crohn's disease.",0
CONCLUSIONS: The use of fluorouracil treatment with careful monitoring can be considered in a patient with mild allergic reactions to capecitabine.,1
Uveitis associated with rifabutin therapy: a clinical alert.,1
"Eventually, both patients were found to have adrenal insufficiency responsible for the fever, which improved after steroid replacement.",0
"Although psoralens are useful components of the psoralen ultraviolet A-range therapy that is mainly used for the treatment of vitiligo, psoriasis, and hypopigmented scars, they have a narrow margin of safety.",0
METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.,1
CASE SUMMARY: A 78-year-old white man presented with intractable lower back pain and constipation.,0
We report a case of DCL that developed in the context of the immune reconstitution inflammatory syndrome (IRIS) in a man with AIDS following initiation of antiretroviral therapy.,0
This patient did not have any predisposing factors for the development of an aortic thrombus before the chemotherapy was initiated.,0
"In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.",1
Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.,1
"The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.",1
"Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.",1
"This syndrome has been associated with the use of aromatic ring-containing agents such as phenytoin, carbamazepine, or phenobarbitone.",0
"In each patient, a different method successfully removed the touch of the anterior vitreous face to the corneal endothelium with subsequent prompt clearing of the corneal edema.",0
"We describe a case of poisoning with 3,4-methylenedioxymet-amphetamine Ecstasy that presented with all the features suggestive of a fatal outcome, including a creatinine phosphokinase level markedly higher than any previously reported.",1
The patient had several acute sinusitis and septic episodes during his acute course.,0
OBJECTIVE: To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis.,1
"Report of a patient with severe transfusion-related acute lung injury after multiple transfusions, resuscitated with albumin.",0
The ocular motor disturbances are probably an expression of regional 5-FU neurotoxicity primarily affecting the brain stem.,1
"Risk factors include previous episodes, dehydration, agitation, polypharmacy, and the rate and route of neuroleptic administration.",0
"Of 165 consecutive patients undergoing computerized tomography- or magnetic resonance imaging-guided stereotactic brain biopsies at the Cleveland Clinic between June, 1987, and November, 1989, four patients (2.4%) developed arterial hemorrhage refractory to conventional efforts to secure hemostasis.",0
The drug has few side effects but some patients have developed clinical features of Cushing's syndrome.,0
"Dipyrone, also known as metamizole, is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis.",1
Mutations were detected in the precore region (nt1896) of HBV.,0
"If opioid drugs are administered before a diagnostic hepatobiliary scan, delayed clearance of Tc-IDA from the common bile duct might lead to an erroneous diagnosis and indicate a potentially unnecessary common bile duct exploration.",0
"Mycobacterium fortuitum is a rare cause of central nervous system infection; however, shunt infection caused by this organism has not been reported.",0
Pathology revealed the sarcoma adjacent to the recurrent ependymoma.,0
This unusual cutaneous sign may be the first sign of methotrexate toxicity.,0
Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.,1
A severe form of exophthalmos resulting from lithium therapy has not been described in the literature.,1
"DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.",1
The presence of inappropriate sexual behaviors in individuals with autistic disorder is one of the important factors disturbing their social adaptation and distressing their families and environment.,0
The treatment of paracetamol overdose with charcoal haemoperfusion and cysteamine.,0
Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.,1
The development of rickets as a complication of chemotherapy for the treatment of Wilms' tumor.,0
"Following an initially uncomplicated recovery, he developed symptomatic hyponatremia.",0
"Although neurotoxicity is a frequent complication of methotrexate therapy, fatal acute neurotoxicity is extremely uncommon, especially in adults.",1
"The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.",1
Pulmonary veno-occlusive disease accompanied by microangiopathic hemolytic anemia 1 year after a second bone marrow transplantation for acute lymphoblastic leukemia.,0
"The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.",1
"Intraocular infection due to Blastomyces dermatitidis is rare, and only 10 cases have previously been reported.",0
"Diagnosed with diabetic ketoacidosis, he was given insulin and saline with discontinuation of all antipsychotics.",0
Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.,1
Evidence of disseminated varicella infection was confirmed at autopsy.,0
"A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.",1
We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.,1
Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine.,1
"In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.",1
Recent evidence has suggested several available methods to monitor free SDC during Fab therapy.,0
An investigation of malaria in a US patient without recent travel established Plasmodium falciparum molecular genotype identity in 2 patients who shared a hospital room.,0
Continued study of the specific mechanisms leading to ventricular tachycardia and sudden death are needed in order to control this increasingly prevalent clinical problem.,0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
"Three patients with niacin-induced visual symptoms had cystoid maculopathy without leakage on fluorescein angiography, and a fourth patient with no fundus abnormality experienced cessation of visual symptoms upon discontinuation of niacin.",1
"Donor hearts were transported from distant hospitals (Tokyo and Miyagi prefecture) and the transportation time was 1 h 33 min and 2h 4 min, respectively.",0
"A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.",1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
We now present four cases of RSDS in kidney transplant recipients treated with tacrolimus.,1
OBJECTIVE: To describe a series of patients with clinically significant lead poisoning.,0
"Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as ""red man syndrome"" and anaphylaxis.",1
Subsequent relaxation training inhibited vomiting after two sessions.,0
"A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.",1
"Especially in small prostates, care should be taken to avoid this condition.",0
After discontinuation of danazol the diabetes completely resolved.,1
"We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.",1
"Using this approach, we observed normal haemostasis, and there were no signs of excessive postoperative bleeding or wound haematoma.",0
Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.,1
"Although useful in the management of chronic alcoholism, disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae, which now include catatonia.",1
"The pathophysiological mechanisms remain unknown, although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab.",1
Radiologic recognition of adriamycin cardiotoxicity.,1
It is suggested that high dosage corticosteroids may damage the posterior blood-ocular barrier.,0
We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil.,1
"Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.",1
"One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.",1
Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.,1
Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.,1
"We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.",1
The patient treated with DBS developed severe dyskinesia a few days after discharge and began self medication with amantadine but showed no improvement.,0
The elevated left ventricular end-diastolic pressure causes the left atrial overload which could be at risk of atrial fibrillation in patients with HCM.,0
High-dose intravenous mannitol infusion in various clinical settings may result in acute renal failure (ARF).,1
The liver also showed peliosis hepatis.,0
Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection.,1
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.,1
We cared for a toddler in whom severe respiratory distress developed after VVR was applied directly under her nose.,0
METHODS: Two patients with exudative age-related macular degeneration were treated sequentially with an intravitreal injection of bevacizumab and developed signs of severe but painless infectious endophthalmitis 2 days later.,1
Stanozolol causes rapid pain relief and healing of cutaneous ulcers caused by cryofibrinogenemia.,0
"This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.",1
"The patient's arthritis flared after the second infusion of infliximab, which was discontinued.",1
A 66-year-old female with chronic renal failure was referred to our hospital because of drowsiness and an acute deterioration of renal function.,0
A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.,1
Spinal artery syndrome masked by postoperative epidural analgesia.,0
Chemonucleolysis is a procedure for treatment of low back pain due to discogenic disease in which the drug chymopapain is injected into lumbar disks to produce chemical dissolution of the nucleus pulposus.,0
"Ultrastructural, fluorescent, and energy-dispersive x-ray microanalysis study.",0
"The most serious dental side effect of bisphosphonate treatment (particularly when it is administered intravenously) is, paradoxically, osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone.",1
CASE: A 58-year-old Caucasian woman was referred to our hospital for chronic unilateral granulomatous panuveitis of the right eye (RE).,0
Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report.,0
"Renal failure is a rare complication associated with the use of rifampicin for the treatment of tuberculosis, usually occurring well into the course of therapy.",1
"The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.",1
"There are several factors which might promote a peripheral ischemic response to vasopressin in the bleeding cirrhotic patient, including altered resting hemodynamics, increased resting sympathetic tone, impaired vasodilation as a compensatory response to vasopressin, and reduced hepatic drug clearance.",0
Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.,1
We describe a case of EGE manifested as an allergy to gemfibrozil.,1
We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.,1
"The coagulation disorders were treated with prothrombin complex concentrate 30 IU/kg IV and vitamin K1 10 mg IV, and values normalized within 36 hours.",0
Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.,1
It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes.,1
"After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.",1
OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.,1
"Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.",1
Abdominal pain deteriorated early in the course of the therapy along with the enlargement of the tumors.,0
Two patients with HLH developed etoposide-related secondary acute myeloid leukemia (sAML) following therapy for HLH.,1
He had been abusing ergotamine compounds for several years on at least 15 days per month.,0
We suggest that familiar TGA could be caused by the mechanism of vasospasm rather than venous congestion and that the abnormal cerebral vasomotor control could be the hereditary substrate in this condition.,0
The thrombus was disrupted during cardiopulmonary resuscitation.,0
"The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.",1
"Efficacy and safety of Etanercept, high-dose intravenous gammaglobulin and plasmapheresis combined therapy for lupus diffuse proliferative nephritis complicating pregnancy.",0
Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.,1
"These four cases, with their varied presenting symptoms, clinical courses, and degree of pathology, emphasize the importance of considering toxic leukoencephalopathy as an etiology of acute neurologic deterioration following high-dose chemotherapy.",0
Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.,1
"Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).",1
Lithium treatment of a patient with periodic catatonia.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"Upon discharge from ICU all laboratory tests were normal and blood lead level was reduced, but he was quadriplegic.",0
"On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.",1
The clinical course of this patient did not support a cause-and-effect relationship between obidoxime and the abnormal liver function.,0
Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.,1
Discontinuation of chlormadinone acetate resulted in decline of the serum PSA level.,0
"A patient with ulcerative colitis developed skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology, while taking sulfasalazine.",1
CONCLUSIONS: TNF-alpha inhibitors in general should be used cautiously in chronic hepatitis B viral infection.,0
We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.,1
Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol.,1
The case reports demonstrate that significant and potentially dangerous side effects from timolol maleate occur as a result of inadvertent overdosing.,0
We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy.,1
Multiple keratoacanthomas developed on the face of a woman after radiation therapy to the nasal sinuses.,0
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.,1
"After clonidine was initiated, the patient's spasticity improved.",0
Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.,1
Fertility was preserved because 7 months later the woman became pregnant and had an uncomplicated pregnancy and delivery at term.,0
The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.,1
We describe a case of a 27-year-old patient whose irritative bladder symptoms showed response to alpha-adrenergic blocking agents on two separate occasions during the course of her treatment.,0
"With serious cases, however, conventional treatment may not allow sufficient time at depth for the complete resolution of manifestations because of the need to avoid pulmonary oxygen toxicity which is associated with a prolonged period of breathing compressed air.",0
The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.,1
"Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.",1
Disulfiram-induced hepatitis.,1
Clofazimine enteropathy caused by crystal deposition can be life-threatening.,1
We report treatment of a 38-year-old man with minimal change disease (MCD) who developed pneumatosis intestinalis (PI) during administration of immune-suppressive agents.,0
Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.,1
Sulfasalazine has been associated with bronchopulmonary complications of inflammatory bowel disease (IBD) in adults.,1
"We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.",1
"We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.",1
The results of these studies could also lead to significant modifications in recommendations for long-term maintenance therapy with cytotoxic agents.,0
Vasculonecrotic reactions in leprosy.,0
Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma.,1
Few studies have been carried out regarding preoperative chemotherapy utilized in the treatment of primitive neuroectodermal tumors/medulloblastomas (PNET/MB).,0
"MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis.",1
The temporal sequence suggests that the drug infusion initiated the lung injury.,0
We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.,1
Severe dapsone hypersensitivity syndrome.,1
Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment.,1
Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.,1
The purpose of this case report and review is to enhance anesthesiologists' understanding of this phenomenon so that they may better formulate a logical treatment scheme in such an event.,0
We report here a rare case of ritodrine-hydrochloride-induced rhabdomyolysis in a pregnant patient with myotonic dystrophy.,1
Anti-hypertensive therapy with propranolol during pregnancy and lactation.,0
"Cultures of the cornea tissue and contact lens storage solution both grew Serratia Marcescens, which was sensitive to ciprofloxacin.",0
"After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.",1
"However, it is still produced and marketed in several countries in Central and South America as well as in Europe, Asia, and Africa.",0
Report of four cases.,0
Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report.,1
"In addition, we suggest that der(17)t(12;17)(q13;p13) should be considered a new recurrent, nonrandom chromosomal abnormality in patients with t-MDS/AML.",0
"She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.",1
He had a similar urticarial rash 1.5 years earlier with this product and was instructed not to use it.,0
"Verapamil, a class IV anti-arrhythmic drug that blocks voltage-dependent calcium channels in cardiac and smooth muscle, also has effects on presynaptic and postsynaptic voltage-dependent calcium channels at the neuromuscular junction.",0
In this paper we present a patient with the diagnosis of nephrotic syndrome and a known history of hepatitis C who received IFNalpha therapy for newly diagnosed CML.,0
Hair loss associated with paroxetine treatment: a case report.,1
"However, supplementation with corticosteroids can lead to recurrence, and care should be taken when corticosteroids are being considered.",0
New lesions gradually spread to the arms and trunk (Fig. 1).,0
In this patient a single plasma exchange was successful in considerably lowering the plasma dextran concentration.,0
Intrahepatic cholestasis and sicca complex after thiabendazole.,1
Thyroid dysfunction has been reported in patients with malignant disease treated with recombinant alpha interferon.,1
"DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.",1
This case highlights the potential of ritonavir interactions even with local injections of a corticosteroid.,0
"However, the medical literature now contains at least 125 other detailed reports of ANLL developing after prolonged cytotoxic agent therapy.",0
"None reported seeing all PPP components, and four saw only the information on the pill packet.",0
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.,1
"An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.",1
Rifampin-associated thrombocytopenia secondary to poor compliance.,1
Nonsurgical management of ectopic pregnancy associated with severe hyperstimulation syndrome.,0
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).,1
"The disease-modifying drugs he was taking, cyclosporin and methotrexate, were stopped, and the lymphoma resolved spontaneously without the use of chemotherapy.",1
The serum concentration of mast cell tryptase approximately 1.5h after the onset of the adverse incident confirmed an anaphylactic reaction.,0
"This case illustrates that a small number of subjects with severe asthma receiving high-dose CS need to be considered as a separate, high-risk group for developing disseminated varicella.",0
"A 21-year-old woman suffering from bipolar affective disorder developed systemic lupus erythematosus (SLE) with characteristic laboratory findings, 18 months after starting carbamazepine maintenance treatment.",1
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.,1
OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.,1
"Thereafter, Mycobacterium tuberculosis was detected in blood cultures and specimens of bronchoalveolar lavage, thus indicating disseminated TB.",0
Mitomycin-C induced hemolytic uremic syndrome: a case report.,1
CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.,1
Management of toxic epidermal necrolysis in a 15-year-old girl.,0
Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.,1
Stupor and fast activity on electroencephalography in a child treated with valproate.,1
Concomitant administration of lithium with olanzapine may place patients at risk for NMS.,1
We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.,1
Anaphylactic reaction to bacitracin ointment.,1
"Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: ""the retinoic acid syndrome"".",1
A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.,1
CONCLUSION: The present findings suggest that fluvoxamine can cause increased libido in some patients.,1
Methylphenidate (Ritalin)-associated cataract and glaucoma.,1
"After 15 minutes, amiodarone infusion (25 microg/kg/min) eliminated further paroxysms in both patients, allowing both interventions to be completed safely and effectively.",0
SLE receded after withdrawal of carbamazepine and treatment with anti-inflammatory drugs.,1
"We postulate that in our patient, a subgaleal hemorrhage developed after vacuum delivery and possibly infected 11 months later, presumably from hematogenous seeding of an acute otitis media.",0
CASES: Two postmenopausal women treated with tamoxifen and progestational agents for breast carcinoma developed uterine enlargement and intermittent spotting.,1
"The rarity of this association with these types of malignancy, together with possible mechanism, is discussed in a brief review of the literature.",0
"A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.",1
Angioimmunoblastic lymphadenopathy (AILD) may respond to thalidomide treatment: two case reports.,0
"A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.",1
Isoniazid and ethambutol as a cause of optic neuropathy.,1
An early asymptomatic recurrence was observed in three patients 49 to 53 days after the initial diagnosis.,0
"Pemphigus herpetiformis, a rare variant of pemphigus, is characterized by erythematous, vesicular, bullous, or papular lesions in a herpetiform pattern, often associated with pruritus.",0
A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V).,1
"This paper reports on a 6.9-year-old autistic male who developed repeated episodes of acute dystonic reactions associated with pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration.",1
We present two cases of neonates with gastric mucosa and submucosa hyperplasia revealed during ultrasound examination.,0
Two patients had abnormal electroretinograms (ERGs).,0
"This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.",1
Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.,1
"CONCLUSIONS: When central nervous system findings are observed in renal transplant recipients, nocardial brain abscess must be considered in the differential diagnosis.",0
"Since early symptoms of the toxic effects of theophylline can mimic peptic ulcer disease, cimetidine might be prescribed for the gastrointestinal symptoms with subsequent worsening of theophylline poisoning.",1
Risks from use of a prescription drug for other than the intended patient are also highlighted by this episode of poisoning.,0
Both children were treated with antibiotics and steroids.,0
Immune reconstitution syndrome following initiation of antiretroviral therapy in a patient with HIV infection and multidrug-resistant tuberculosis.,0
Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.,1
"Dasatanib, which has been approved for rescue therapy for patients with imatinib-resistant chronic myelogenous leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia, is a novel, orally available multitargeted kinase inhibitor of BCR-ABL and SRC family kinases (Quintas-Cardama et al, J Clin Oncol 2007;25:3908-14).",0
"Narcolepsy, paranoid psychosis, and analeptic abuse.",0
"Preliminary results suggest that the higher concentrations of dextrose induce increased histamine release from blood cells, and that this phenomenon is more marked in diabetic, and particularly diabetic-allergic, individuals.",1
"We report on a patient with subarachnoid haemorrhage who developed an acute life-threatening pseudo-obstruction of the colon, a variant of adynamic ileus, while being treated with intravenous nimodipine.",1
We report a premature infant who developed seizures associated with intraventricular administration of nafcillin and discuss the need for electroencephalographic monitoring of patients receiving intraventricular antibiotics.,1
We describe a characteristic speech disorder identified in a large series of consecutive patients undergoing OLT.,0
Magnesium tocolysis as the cause of urinary calculus during pregnancy.,1
Photo-onycholysis associated with drugs is an uncommon disorder.,0
"Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.",1
"With the increased use of neoadjuvant chemotherapy, it is important to recognize previously undescribed mammographic findings secondary to this therapeutic approach.",0
Optimizing antithrombotic therapy in patients with non-ST-segment elevation acute coronary syndrome.,0
DATA SOURCES: Case reports and review articles identified by MEDLINE.,0
Heat stroke-like episode in a child caused by zonisamide.,1
Her mood improved significantly.,0
The use of combined therapy with an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II receptor blocker (ARB) for treatment of proteinuria has been gaining support.,0
Cerebral sinus thrombosis associated with acquired free protein S deficiency is very rare.,0
Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.,1
HBsAg seroconversion was achieved after an additional 12 months.,0
"Immunohistological studies showed that these cells were positive for CD30 and CD79a, but not for CD15 or CD20.",0
"A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",1
Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.,1
"The third patient, who was elderly, survived because of early detection and initiation of therapy.",0
"However, graft function could not be restored.",0
Both patients had received brief courses of spironolactone before arginine treatment.,0
Successful treatment of invasive aspergillosis complicating prolonged treatment-related neutropenia in acute myelogenous leukemia with amphotericin B lipid complex.,0
"In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.",1
"The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.",1
"To our knowledge, their occurrence in the same patient has not hitherto been described.",0
We describe a case of prolonged terbinafine-induced cholestatic liver disease.,1
"A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.",1
"Levosimendan (LS) is a novel calcium sensitizer drug that enhances cardiac contractility without increasing myocardial oxygen consumption, and induces vasodilatation.",0
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.,1
Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis.,1
Depressive symptoms disappeared after interferon therapy was stopped.,1
"In both our cases, such a regimen did not prevent the occurrence of endometrial polyps which, although histologically benign, were usually large and thought clinically to be malignant.",0
Use of portable blood analyser in prehospital care should be considered in case of suspected massive poisoning by ethylene glycol.,0
"Intraocular pressure (IOP) was not able to be controlled medically, however, and filtering surgery 20 days post laser treatment was required.",0
This observation suggests that endogenous estradiol may play a beneficial role in male patients with chronic hepatitis C.,0
This case demonstrates the importance of blood flow from the peribiliary arteries for the survival of the biliary epithelium.,0
We have reported the first case of successful treatment of disseminated histoplasmosis in a renal allograft recipient using a short course (14 days) of amphotericin B in combination with prolonged therapy (161 days) with ketoconazole.,0
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
"After the start of insulin therapy, there was a remission period for about 3 years but insulin-dependency recurred thereafter.",0
Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.,1
"In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.",1
The process worsened during the two weeks following steroid cessation.,0
Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect.,1
"Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.",1
There was no evidence of renal hypoperfusion or interstitial nephritis.,0
"Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.",1
"The expected number of AML/MDS developing in a general population of the same size was 1.2 as calculated from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program data (observed-to-expected ratio = 2.49; 95% confidence interval = 0.9-7.3; p = 0.12).",0
"Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.",1
"Here, we report a case of RFP-induced hypothyroidism without underlying thyroid disease.",1
CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients.,1
This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.,1
"To avoid hyperuricemia and an acute attack of gout after RFA therapy for HCC, early identification of patients at risk is warranted, such as those with a large tumor, rapid tumor growth, and renal insufficiency, and preventative measures should be considered.",0
The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.,1
"Depression was not improved and she complained of fatigue, lack of energy and drowsiness.",0
The advantages and disadvantages of uncontrolled case reports are reviewed using two cases of false-positive reactions to drugs as illustrative examples.,0
Intraocular ointment after small-incision cataract surgery causing chronic uveitis and secondary glaucoma.,0
"The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.",1
Risperidone-induced psychosis and depression in a child with a mitochondrial disorder.,1
"To our knowledge, drug-induced fever has not been reported with the use of diltiazem hydrochloride, a commonly prescribed calcium channel blocker.",1
"In all three cases, autopsy revealed gross and microscopic features indistinguishable from those seen in the Hamman-Rich syndrome, and methotrexate hepatotoxicity was present in one.",1
"The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.",1
Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.,1
"She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.",1
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.,1
An increase in exercise capacity was reported by 78% of patients; objective measurements showed that the mean value of VO2max in a subgroup of 11 patients increased by 50% after treatment.,0
"His oral medications included topiramate, carbamazepine, olanzapine, quetiapine, guanfacine, and desmopressin acetate.",0
"During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.",1
"Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.",1
Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.,1
Autopsy revealed that cortical and subcortical structures were normal without neuronal necrosis or eosinophilia.,0
"In the hospital, she continued to receive TPN without MVI, but continued taking an oral multivitamin preparation.",0
Visual loss after a single small dose of vincristine has never been reported.,1
Anaphylactic/anaphylactoid reactions to methotrexate are rare.,0
"She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.",1
Cerbral angiography revealed evidence of an arteritis with bilateral high grade carotid stenosis.,0
"Initial cases were associated with anticonvulsants, although other drugs have now been implicated.",0
Treatment with an epidural blood patch (EBP) via the caudal approach resulted in complete relief of symptoms.,0
"Additional typical findings were the high excretion of adipic acid, suberic acid, and 4-octen-1,8-dicarboxylic acid demonstrating the enhanced capacity of omega-oxidation in fatty acid oxidation.",0
Possible relationships between the white matter lesions and extrinsic toxic agents are discussed.,0
Increased libido in a woman treated with fluvoxamine: a case report.,1
On admission the patient showed signs of incipient cardiogenic shock.,0
Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.,1
"Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist.",1
"Quinapril is an angiotensin-converting enzyme inhibitor (ACE-inhibitor) and overdose can lead to prolonged hypotension and, less frequently, transient renal impairment.",1
We report a case of fatal adenovirus infection in a 37-year-old female who underwent allogeneic bone marrow transplantation (BMT) for acute myelogenous leukaemia (AML).,0
The patient has since returned to his routines of daily living and has reported no fatigue or other lingering adverse symptoms.,0
Diagnosis of HUS was confirmed histologically in 13 patients and based on clinical findings in the other 15.,0
"Six (25%) of 24 patients died of this infection; however, only one (5%) of 19 who were treated with adequate antimicrobial therapy died.",0
Pregnancy limits the therapeutic options for managing thrombocytopenia which occurs in 5% of patients on heparin.,0
"Hyperglycemia induced by the first product improved after the substitution, suggesting that the Erwinia enzyme may be less diabetogenic than the E. coli enzyme.",0
"The second was an 82-year-old man receiving ticlopidine for 2 years when, during a febrile episode, he was found neutropenic with marrow aplasia.",1
Anorexia in a 14-year-old girl: why won't she eat?,0
Acute coronary syndromes complicating the first infusion of rituximab.,1
AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.,1
We report a case of torsade de pointes following a single oral dose of amiodarone (1400 mg or 30 mg kg-1) administered after short intravenous loading for prevention of paroxysmal atrial flutter.,1
"The day after methotrexate administration, the patient complained of severe back pain and urinary retention.",1
We report two male patients with Parkinson's disease who developed compulsive risk-seeking driving behaviour as a result of self-administering high doses of L-dopa despite an adequate therapeutic response at lower doses.,0
These remained the only agents for the next 50 years.,0
"Parameters of potassium, sodium, calcium, and phosphate metabolism as well as specific renal functions have been studied in the basal state and during administration of graded doses of phosphate (500-6000 mg).",0
Its major side effect of anaemia limits its use in some patients.,0
Various toxicities have been observed during the treatment of advanced renal cell carcinoma with interferon-alpha (IFN-alpha) and/or interleukin-2 (IL-2).,0
"CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.",1
Palmar-plantar erythrodysaesthesia (PPE) is an uncommon cutaneous complication of cytotoxic chemotherapy which generally presents as a painful erythema involving the palms and soles.,0
"Significant deteriorations were demonstrated in cognitive (p = 0.04) and social functions (p = 0.04), compared with assessment of pre-morbid function.",0
CONCLUSIONS: Colchicine-induced myopathy should be excluded in patients with FMF who present with generalized muscle weakness.,1
Hypertensive reactions occurred without obvious cause in two patients receiving monoamine oxidase inhibitors (MAOIs) while being monitored in a hospital.,0
RESULTS: The use of ECT in patients with MG is a viable therapeutic option when psychiatric complications secondary to MG or its treatment do not respond to psychotropic medications.,0
"We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.",1
The development of nephrotic-range proteinuria after renal transplantation is an unfavourable prognostic factor for graft survival.,0
"This complication has not previously been reported during treatment with sargramostim, a hematopoietic cytokine with activity that overlaps filgrastim.",0
"The occurrence of treatment-related hematologic malignancies after adjuvant therapy with alkylating agents for gastrointestinal cancers, ovarian carcinoma, and breast cancer and after treatment for Hodgkin's disease, non-Hodgkin's lymphoma, germ-cell tumors, and multiple myeloma has been well documented.",0
I report a 35-year-old woman with occult coronary artery disease who experienced cardiac arrest within minutes after receiving a first-time dose of subcutaneous sumatriptan for migraine.,1
Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.,1
It may induce rapid apoptosis and subsequent tumor lysis syndrome.,0
"This is the first case of PML after SCT treated with cidofovir, and the fifth case treated with this drug in a patient without human immunodeficiency virus (HIV) infection.",0
"DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.",1
Tooth brushing-induced seizures: a case report.,0
"The itch spread to the arms, abdomen and legs and the patient treated himself with clemastine and the itch disappeared.",0
Different pathologies have been described as caused by henna.,0
BACKGROUND: Dyskinesias are a transient but severe complication of subthalamotomy in some patients.,0
"A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.",1
"Despite the known pulmonary side effects of nitrofurantoin, there is no report of this toxicity occurring in pregnant patients.",1
Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.,1
Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.,1
Administration of intravenous nitroglycerin in a patient with idiopathic pulmonary hypertension resulted in an increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance.,1
This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.,1
"While thrombolysis is a first-line treatment option in massive PE and acute MI, cardiopulmonary resuscitation (CPR) has been regarded as a relative contraindication for thrombolysis because of the anticipated bleeding risk caused by traumatic cardiocompressions.",0
"Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.",1
Video game epilepsy is considered to be its variant or a pattern sensitive epilepsy.,0
"We report the displacement of a tunnelled intrathecal catheter causing significant cerebrospinal fluid (CSF) leak, resulting in partial coning and a sixth nerve palsy.",0
We compared patient reports with reports from healthcare professionals.,0
DESIGN: Case series.,0
"Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.",1
"The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.",1
This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.,1
CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.,1
"Using repeated computed tomographic and magnetic resonance imaging scans, we examined 8 patients with acute lymphocytic leukemia during remission induction therapy between 1988 and 1989.",0
"Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation.",1
"The in vitro susceptibility assay showed that the clinical isolate was resistant to foscarnet, moderately resistant to ganciclovir, but sensitive to cidofovir.",0
Regular surveillance of the patient detected a 3.5 cm HCC lesion.,0
"Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).",1
The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.,1
"A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.",1
"The authors report a case of acute pancreatitis (AP) occurring in a patient under treatment with carbamazepine (CBZ) for post-traumatic petit mal epilepsy, and review the current literature of drug-induced AP.",1
Methylphenidate (Ritalin)-associated cataract and glaucoma.,1
"Epidural steroid injections are relatively safe procedures, although the risk of hemorrhagic complications in patients undergoing long-term anticoagulation therapy is higher.",0
Concentric retinal pigment epithelium atrophy after a single photodynamic therapy.,0
"CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age.",1
We report a case of hyponatremia associated with a grand mal seizure in a 28 month-old child after intra-nasal desmopressin administration for high fluid intake with nocturnal enuresis.,1
"CASES: A 37-year-old man with chronic hepatitis C and a 59-year-old man with chronic myeloid leukemia, both of whom had received IFN therapy, were referred to our outpatient clinic.",0
"The maculopapular rash progressed to formation of confluent nodules, plaques and finally erythroderma with lymphadenopathy and hepatosplenomegaly.",0
CASES: Two postmenopausal women treated with tamoxifen and progestational agents for breast carcinoma developed uterine enlargement and intermittent spotting.,1
"The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.",1
BACKGROUND: Uterine malignant mixed mesodermal tumor is a rare variant of uterine cancer.,0
"After standard treatment had failed, we tried to treat the patient by administering rituximab directly into the cerebral ventricle through an Omaya reservoir, in addition to conventional intrathecal and systemic chemotherapy.",0
"The treatment improved the childrens' clinical condition prior to surgery and facilitated tumor removal, resulting in partial regression of the tumor.",0
Xanthomonas maltophilia endophthalmitis after cataract extraction.,0
A 37-year-old woman with relapsing invasive vertebral aspergillosis received intravenous VRC and developed angio-oedema 10 days after starting therapy.,1
Liver disease induced by perhexiline maleate.,1
Acute onset of nephrotic syndrome during interferon-alpha retreatment for chronic active hepatitis C.,1
Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate.,1
Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.,1
"Furthermore, radial keratoneuritis was demonstrated, consisting of an irregularly swollen nerve fiber with probable amoebic infiltration.",0
Disseminated superficial porokeratosis and immunosuppression.,0
Acute renal failure in a patient receiving treatment with suramin.,1
Over the last five years three new classes have been released.,0
Congenital cytomegalovirus (CMV) infection occurs in approximately 1% of newborns and is the leading infectious cause of congenital birth defects.,0
We report five cases of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) that were probably associated with olanzapine.,1
"The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.",1
We report a case of Ritalin-associated cataract and glaucoma.,1
"On hospital day 47 (day 45 of nesiritide therapy), the patient received an 18-fold overdose of nesiritide, with no hemodynamic, cardiac, or renal sequelae.",0
Resolution of recalcitrant warts with IV Cidofovir has been reported in a limited number of cases.,0
Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression.,1
Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.,1
"CONCLUSIONS: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon alpha administration.",1
His inhibitor titres ranged from 10 to 3450 Bethesda units (BU).,0
Glaucoma from topical corticosteroids to the eyelids.,0
"Normeperidine is eliminated by the kidneys and accumulates in patients with renal insufficiency, sickle cell disease, and cancer.",0
This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.,1
Myotonia associated with sarcoidosis: marked exacerbation with pravastatin.,1
"Subsequently, he developed hyperglycemia (fasting blood glucose 138 mg/dL) that resolved when olanzapine was stopped and recurred (fasting blood glucose 150 mg/dL) after 2 days of rechallenge with olanzapine 2.5 mg twice daily.",1
The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate.,1
Analysis of the literature on scrofuloderma between 1978-1993 disclosed that the number of cases with extracervical involvement are increasing.,0
"We present a unique case of extensive BRONJ involving the maxilla, sinuses, and skull base, complicated by sinusitis and an intracranial abscess.",0
"After low-molecular-weight heparin was substituted for unfractionated heparin, the thrombocytopenia resolved and although the pregnancy was lost, the patient made a full recovery.",0
This study reports the results of a retrospective review of the case records of 28 seriously ill patients who received intravenous cimetidine (generally 300 mg q8h) for the treatment of gastric discomfort and/or hemorrhage or for prophylaxis against stress-induced ulcers.,0
A report of retinal artery occlusion associated with mitral valve prolapse and pregnancy is presented.,0
"One patient underwent coronary angiography which disclosed no pathology, but following which, while on a calcium channel blocking agent regimen, he had an uneventful course of chemotherapy with cisplatin.",0
"Some chemicals can cause burning in the mucosa of cheeks, lips, tongue, and palate.",0
Fluorouracil for allergic reactions to capecitabine.,1
"CONCLUSIONS: Given the fulminant course of amphotericin B deoxycholate overdosage and lack of effective therapy, stringent safeguards against its improper administration should be in place.",0
Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.,1
"CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment.",1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
"The final diagnosis in each of these patients was drug-induced pneumonitis, which responded to treatment with corticosteroids.",0
"Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.",1
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.,1
"CONTEXT: Previous investigators have reported discrepancies between hematologic, marrow morphologic, and cytogenetic responses to imatinib mesylate among patients with chronic myeloid leukemia (CML).",1
"A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.",1
Delirium in the intensive care unit: are we helping the patient?,0
We speculate that platelet activation induced by pFVIII may have contributed to thrombosis and suggest that pFVIII be used with caution in elderly patients with pre-existing cardiovascular risk factors.,1
"These findings, together with increased urinary copper excretion and the absence of clinical improvement, are compatible with a generalized defect in copper metabolism, transport or storage.",0
Nonsustained polymorphous ventricular tachycardia during amiodarone therapy for atrial fibrillation complicating cardiomyopathy.,1
"By contrast, corticosteroids inhibited the LAR but not the immediate response.",0
"Careful clinical and biochemical monitoring seems necessary in children with primary glomerulonephritis, other than those transplanted, after IVPMP, and factors predisposing to neurologic sequelae should be further defined.",0
CASE DESCRIPTION: A 21-year-old male was initially evaluated because of a large mass that had been growing for 7 months.,0
"She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.",1
"Pharmaceutical drugs, industrial compounds, and inhaled particles have been implicated as causative agents.",0
Phenol is a neurolytic agent that is widely used by percutaneous retrogasserian injection in the treatment of trigeminal neuralgia.,0
The critical care provider is faced with deducing the etiology and treatment of delirium in the ICU.,0
Occurrence in an immunosuppressed patient with chronic active hepatitis.,0
A diagnosis of phenytoin toxicity was made and she was treated by withdrawing the medication.,0
"Accordingly, camptocormia is a dose-dependent side effect of valproate.",1
"The quality of life was assessed in 37 maintenance hemodialysis patients during treatment with recombinant human erythropoietin (r-HuEPO; EPOGEN [epoetin alfa], AMGEN Inc, Thousand Oaks, CA) for correction of anemia.",0
Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.,1
"We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.",1
Chloroquine-induced bilateral ptosis.,1
"Gastrointestinal disturbances were reported in six patients, and hypotension in six.",0
"Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.",1
CONCLUSIONS: Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.,1
Adenosine has become the preferred treatment for common types of supraventricular tachycardia because it is extremely effective and rarely associated with with serious side effects.,0
"Several recent series have suggested that, in most cases, CMV reactivation does not lead to severe complications and resolves spontaneously with the UC flare and discontinuation of immunosuppression.",0
"The onset of symptoms after fluorescence in both cases is highly suggestive, although the pathogenetic mechanism is not clear.",0
A trial of thrombolytic therapy with tissue plasminogen activator infusions was started at 0.1 mg/kg/hr for 6 hrs daily.,0
METHOD: The authors present a three-case series in which risperidone was used to treat delusions of infestation.,0
"Later, more careful research showed that they are not directly associated with the antipsychotic activity of neuroleptic agents.",0
Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy.,1
"After 4 years in complete remission, he developed a CD20-negative T-cell-rich B-cell lymphoma (TCRBCL) presenting as multiple lung lesions.",0
"Treatment is mainly discontinuation of the drug, however, corticosteroid therapy is recommended for severe reactions.",0
Three patients are presented in whom life-threatening cardiac arrhythmias dominated the clinical presentation.,0
"On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.",1
"A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.",1
Computed tomography re-evaluation demonstrated a new liver lesion.,0
"An extraordinarily rare case report of mixed fat redistribution syndrome associated with osteopenia but not with relevant metabolic abnormalities is documented in a prepubertal child with congenital HIV infection treated with antiretroviral therapy since the age of six months, up to the present age of 12 years and two months.",0
Unexpectedly high toxicity of MACOP-B in young patients with low grade lymphoma.,0
"Additionally, a baby bottle allegedly administered to the infant was collected as evidence and sent to the Medical Examiner's Office for evaluation.",0
"Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.",1
Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.,1
Eight deaths that occurred during Upjohn-sponsored clinical trials of topical minoxidil and two deaths in subjects who used extemporaneous formulations of the drug are summarized.,0
"Resolution of symptoms, physical signs and radiographic changes followed drug withdrawal and steroid therapy.",0
The reason for this is discussed.,0
"In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.",1
The pathogenesis and management of this process are reviewed.,0
A patient developed cholestatic hepatitis while being treated with nitrofurantoin.,1
"Necropsy findings indicated that the pancreatic adenocarcinoma had metastasized to surrounding tissues and vessels, which was not unexpected given the high grade assigned to the neoplasm during histologic analysis.",0
An elderly man with procainamide hydrochloride-induced lupus syndrome had a circulating anticoagulant against factor XI and a biologic false-positive (BFP) test result for syphilis.,1
"The authors think that although lamivudine is widely used and well tolerated, it can cause ADRs, which are reversible after drug withdrawal.",1
"This case reveals that HPS could develop after alloBMT, even when engraftment of hematopoietic cells is not confirmed.",0
"Clinicians need to be aware of this rare but potentially fatal side effect in patients of all ages, and especially in adolescents receiving both drugs.",0
Lansoprazole-associated collagenous colitis: a case report.,1
"After discontinuation of treatment with levamisole and a short course of corticosteroid therapy, the patient's condition dramatically improved.",0
A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.,1
We suggest being aware of such reactions during omeprazole usage.,0
The fourth patient showed RLS symptoms that were initially caused by a 20-mg daily olanzapine dosage and were later mitigated when olanzapine was reduced and ropinirole was administered.,1
Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.,1
Analysis of cerebrospinal fluid showed significant pleocytosis and hypoglycorrhachia.,0
"However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.",1
"During the terminal stage, a considerable decrease in the size of the liver was observed.",0
"The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.",1
"OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.",1
"A patient was admitted to the intensive care unit because of respiratory failure, and warfarin therapy was started at 2 mg/day for the treatment of pulmonary embolism, together with other medications.",0
Two patients are described who developed testicular swelling and pain during treatment with desipramine.,1
He sustained a myocardial infarction on postoperative day 7 and progressively deteriorated and expired five days later.,0
New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept.,1
Phenytoin toxicity: an easily missed cause of cerebellar syndrome.,1
Use of baclofen in the treatment of esophageal stent-related hiccups.,0
"We believe that this impairment in driving performance, due to deliberate overuse of dopaminergic medication, should be included as a new behavioural phenomenon in dopamine dysregulation syndrome.",0
"Eleven days after initiation of therapy with amiodarone, the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia.",1
"To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.",1
A preliminary study of a combination of pentoxifylline (PTX) and tocopherol (vit-E) has shown clinical activity with 50% superficial RIF regression at 6 months in half of the patients studied.,0
We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.,1
The complete treatment schedule required the administration of a total of 708 mg of recombinant FVIIa.,0
Aluminum infusions should be used with caution in patients with renal failure.,0
Acute lymphoblastic leukemia as a second malignancy following the treatment of medulloblastoma is a very rare condition.,0
It is believed to be the first case of cryptococcal meningitis recorded in a child in Saudi Arabia.,0
"We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.",1
Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.,1
Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.,1
"A month later, he developed clinical and biochemical evidence of modest hepatocellular injury, and therapy was stopped.",0
The association of NEH and the use of cytotoxic agents for SLE or other autoimmune diseases has not been reported previously.,0
There is no study on the incidence rate among children with systemic malignancies.,0
Hydrocortisone prophylaxis and verapamil therapy were the primary therapies used in patient 1 (the only survivor).,0
OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.,1
A 44-year-old woman with a previous diagnosis of multiple sclerosis presented with panuveitis and retinal perivasculitis.,0
"Abnormal behaviour consisted of elevated mood, euphoria, and increased energy in both patients, and pressure of speech and decreased need for sleep in one of them.",0
Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.,1
"There were gross functional lesions of the cardiovascular, renal, and neuromuscular systems with no structural abnormalities.",0
Multiple complications can occur as a consequence of insertion of a VAD.,0
Myelodysplasia terminating in acute myeloid leukemia in a hairy cell leukemia patient treated with 2-deoxycoformycin.,1
"In November of 2000, the Food and Drug Administration (FDA) requested a voluntary recall of the product from all manufacturers.",0
46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.,1
A change in government program policies caused him to receive generic carbamazepine.,0
"Twelve hours after admission, ""diabetic ketoacidosis"" was diagnosed on the basis of elevated glycaemia, glycosuria, ketonuria and a low bicarbonate blood level, which led to treatment with fluids and regular insulin infusion.",0
"This is probably due to the presence of a common ingredient, styrax gum.",0
"In this report, we present a rare case of gastro-duodenal ulcer following selective internal radiation therapy (SIRT).",0
BACKGROUND: Hydroxyurea is a cytostatic agent used to treat myeloproliferative disorders and long-term treatment is associated with mucocutaneous adverse events and nail hyperpigmentation.,1
"Again, the pneumonitis was fully reversible.",0
RESULTS: All three patients developed a biochemical-histologic pattern of cholestatic liver injury with damage to the interlobular bile ducts.,0
We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.,1
Bosentan and warfarin interaction.,0
"Commonly, opioid drugs are administered in patients with acute cholecystitis to relieve pain.",0
These reactions recurred immediately after the second dose.,0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.,1
We report our conventional magnetic resonance and diffusion-weighted imaging findings and briefly discuss the pathophysiology of the syndrome.,0
OBJECTIVE: To describe a newly recognized adverse effect of imiquimod.,0
"We treated 21 patients with stage D prostatic adenocarcinoma who had had unsuccessful hormonal therapy with a combination of 600 mg. per M.2 per day estramustine phosphate (Estracyt) and 15 mg. per M.2 per day prednimustine (Stereocyt, Leo 1031) in daily oral doses.",0
"Within 24 h of pulse therapy, they complained of palpitations and developed atrial fibrillation which reversed spontaneously or after anti-arrhythmic therapy.",0
The azathioprine dose was low (1 mg/kg) and pancytopenia occurred after 56 days therapy.,1
"INH, which is a leading cause of drug eruptions in the above group of drugs was withdrawn.",1
Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).,1
"Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.",1
Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a severe multiorgan reaction with reactivation of herpesviruses.,0
Psoas abscess following ileo-anal pouch surgery.,0
"Celecoxib, a cyclooxygenase (COX)-2 inhibitor, was administered for pain management and for potential antineoplastic activity.",0
"Hemolytic uremic syndrome appeared, while no evidence of residual tumor was found.",0
"A senile patient showed a dramatic recovery from medication-resistant depression after non-convulsive electroshock therapy (nc-EST), with a lasting change in response to trazodone, which mainly acts as a serotonin re-uptake inhibitor.",0
"This 4-year-6-month-old girl had a history of moderate developmental delay and had received HOPA administration when first admitted at 2 years 6 months of age with hypoglycemia, hyperammonemia, lactic and pyruvic acidemia, and non-ketotic dicarboxylic aciduria.",0
"For nearly half a century, FMF was thought to cluster primarily in non-Ashkenazi Jews, Arabs, Armenians, and Turks, although the screening of the 8 known mutations in an American cohort has identified substantial numbers of people from the Ashkenazi Jewish and Italian populations in the United States who also have this disease.",0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"The dermatomes below the Th9 lost all somatic sensation on the left side after the nerve blocks, but the patient was not completely relieved from the pain.",0
PATIENTS: Two patients with phantom limb pain after total hip disarticulation.,0
"However, in rare instances, hemorrhagic pancreatitis or necrosis may occur.",0
Priapism associated with olanzapine.,1
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
"The cure rate of this disease has been reported to be lower than for non-drug resistant TB, and the use of new experimental drugs in combination therapy is warranted.",0
Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.,1
The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.,1
She began to recover after 10 days of supportive therapy and was discharged several weeks later on primidone therapy.,0
METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.,1
"After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.",1
Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.,1
"A 44-year-old Caucasian male who had been on long-term steroid treatment for an unspecified collagen disease was referred to our Unit because of fever, severe hypopharyngeal dysphagia, night sweats and evidence of marked superior vena cava compression.",0
A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.,1
"However, the impact of cytomegalovirus on PTLD remains to be determined.",0
"His weekly warfarin dose was increased by approximately 5%, and he was given three fecal occult blood cards.",0
We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).,1
We describe 2 patients with prior amputation who experienced phantom limb pain (PLP) after receiving paclitaxel therapy.,1
The plasma concentration of pirmenol was at a subtherapeutic level and the lymphocyte stimulation test was positive in this patient.,0
"There was no clinical or laboratory evidence for an immunologic or toxic insult, although in 1 patient we found a transient leukocyturia and mild proteinuria.",0
Paraplegia following prophylactic intrathecal cytosine arabinoside (Ara-C) is described in a patient with acute myelogenous leukemia in remission who received doses of 100 mg/m2/d for 5 consecutive days.,1
"However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.",1
Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness.,1
"Toxicology testing confirmed the presence of strychnine in blood, gastric aspirate, and urine.",0
"Three-months after implantation of the intravenous access device, the indwelling central catheter was fractured and embolized to the pulmonary trunk.",0
Report of two cases with evidence from serial computed tomographic brain scans.,0
"To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan.",1
"In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.",1
We therefore assume that the risk of severe neurological complications is underestimated.,0
"Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.",1
The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn.,0
"A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.",1
We report an example of ACC and review the relevant literature.,0
Crumley).,0
The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.,1
"Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.",1
Histopathology was suggestive of a cutaneous drug eruption.,0
"Mostly, reactivation occurs during first 3 months after transplant, especially when risk factors are present.",0
"Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts.",1
"The six patients who received mecamylamine only also significantly improved (Wilcoxon signed rank test, p < 0.2).",0
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
"The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.",1
Neonatal mydriasis: intravenous lidocaine adverse reaction.,1
The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped.,1
Intrathecal application of chemotherapeutics has been the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia treatment.,0
We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.,1
"The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).",1
Encephalopathy and seizures induced by intravesical alum irrigations.,1
"Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.",1
"We describe an infant with minimal exposure to oxygen who developed AP-ROP that led to bilateral retinal detachments and a poor visual outcome, despite following current recommended screening guidelines.",0
"Recurring periods of prolonged erections in patients with sickle cell disease (stutter priapism) are uncommon, yet troubling sequelae of hemoglobinopathies.",0
"The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.",1
"It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.",1
"A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.",1
"Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.",1
Aliskiren-associated acute renal failure with hyperkalemia.,1
"CONCLUSION: When performing posterior cervical decompression, surgeons must be aware of the potential for loss of normal lordosis and anterior displacement of paraspinal muscles against the spinal cord, especially in muscular patients.",0
Here we describe two cases in postpneumonectomy patients in which expandable esophageal stent placement resulted in respiratory compromise requiring reintervention due to airway compression.,0
"We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.",1
A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.,1
This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm.,1
We report a patient with supralethal magnesemia of 38.7 mg/dL who survived.,0
Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.,1
"Debris was probably flushed into the external carotid artery, and passed through an anastomosis into the ophthalmic artery, resulting in retinal artery embolization.",0
"After 1 month of treatment, he was diagnosed as having acute renal failure secondary to HUS.",0
Fundus examination revealed resolution of cystoid macula edema.,0
"He relapsed a month later with Enterococcus gallinarum shunt infection, which responded to high-dose ampicillin and gentamicin therapy.",0
Disseminated intravascular coagulation in pregnancy.,0
Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.,1
"BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.",1
"Although clonazepam therapy is not new, it appears to have been omitted from current pain texts and journals as a treatment option for phantom limb pain.",0
Tacrolimus (FK506)-induced mutism after liver transplant.,1
"The ability of clozapine to suppress tardive dyskinesia symptoms raises the possibility that clozapine, at least at the doses used in this report, might also induce the disorder.",0
Treatment of neutropenia in a renal transplant recipient with granulocyte colony-stimulating factor.,0
"The pathogenesis, through retrograde spread of superficial infection to durocortical veins, is discussed in the light of serial CT scans at different stages of formation and treatment of the abscess.",0
Topical tacrolimus appears as an effective and safe treatment of symptomatic OLP.,0
Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).,1
CONCLUSIONS: Amantadine can cause reversible corneal edema but can irreversibly reduce the density of endothelial cells.,1
"CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.",1
Propylthiouracil-induced cutaneous vasculitis.,1
Ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect.,1
Prednimustine is an ester of chlorambucil and prednisone.,0
In a review of the literature no report of a similar case was found.,0
"In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.",1
A patient experienced methadone withdrawal symptoms when combining these agents.,0
"We also showed that the drug was inhibitory to fungi in vitro as a vapor, not requiring contact by diffusion through agar or broth.",0
It may be due to several causes with different outcomes.,0
Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease.,1
Intravenous bisphosphonates have come into increasing use to protect cancer patients from adverse boney events.,0
"A woman with a prolonged unipolar delusional depressive episode, unresponsive to antidepressant treatment, experienced rapid improvement of depressive and psychotic symptoms following the occurrence of two grand mal seizures.",0
Squamous cell carcinoma in vitiligo lesion after long-term PUVA therapy.,0
Over the next few days he showed rapid clinical improvement with normalization of his blood chemistries and he was discharged home after 5 days of hospitalization in good condition.,0
"In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.",1
"Based on newly published data we have applied an infusion of both compounds, 5-FU and calcium folinate, mixed together in an ambulatory pump.",0
The hearing impairment and tinnitus were gradually reduced after PTU withdrawal and corticosteroid and azathioprine treatment.,1
"He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.",1
"Perhaps for this reason, the teeth and craniofacial features of patients with leprechaunism have never been reported.",0
Without any further intervention the patient had 2 separate and prolonged PSA increases and decreases 12-35 months after therapy.,0
"Eleven of those patients also experienced clinically compromising anemia, transfusion with packed red blood cells, renal insufficiency, dialysis, or death.",0
We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.,1
Reperfusion of the transplanted heart was performed retrogradely through the coronary sinus utilizing leukocyte-depleted blood with a gradual increase in temperature.,0
Fever caused by the use of furosemide was proved; the fever resolved after discontinuation of this medication and recurred after its reintroduction.,1
"Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.",1
Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.,1
Placental changes after thrombolytic therapy have rarely been reported.,0
"Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction.",1
"CONCLUSIONS: Atypical antipsychotic-induced diabetes does not always take a ""type 2"" presentation in which weight gain and insulin resistance are implicated.",0
Corneal endothelial deposits associated with rifabutin use.,1
"However, whether or not the microgranulations were bacterial colonies, infection did not recur during a 2-year follow-up period.",0
"CONCLUSION: Based on the easily managed toxicities and apparent efficacy of the regimen of weekly nab-paclitaxel and daily sunitinib, we conclude that further evaluation is warranted to assess the efficacy of this combination therapy in previously chemotherapy-treated patients with advanced thoracic cancer.",0
"He was then scheduled to receive adjuvant chemotherapy with high-dose MTX, 12 g/m2 body surface area, followed by leucovorin rescue and ifosfamide.",0
RESULTS: A total of 861 patients with ischemic stroke were admitted to Calgary hospitals during the study period.,0
"Toxic epidermal necrolysis, a life-threatening reaction to certain types of drugs, is characterised by epidermal sloughing of more than 30% of the total body surface area.",0
PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.,1
Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.,1
"Postoperatively, a continuous epidural infusion of fentanyl/bupivacaine was used for postoperative pain management.",0
"Despite a hematologic response in all 3 patients, none of them achieved cytogenetic remission, and all progressed to blast crisis at 7 to 10 months of imatinib therapy.",1
CONCLUSION: Infliximab can be used successfully for the treatment of pediatric patients with Crohn's disease and IPAA who are refractory to conventional therapies.,0
Cerebral infarction due to an embolism after cervical pedicle screw fixation.,0
"Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.",1
"The administration of ""sweet spirits of nitre"" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.",1
Osteonecrosis in patients with testicular tumours treated with chemotherapy.,0
Plasma cryofibrinogen was measured before and during treatment with stanozolol.,0
We discuss this case and issues arising from it related to the use of CD34+ selected stem cells for transplantation.,0
During admission she was found to be profoundly hypothyroid despite being on adequate thyroid replacement therapy.,0
METHODS: A 44-year-old patient showed therapy-resistant cystoid macular edema for 2 years after repeated penetrating keratoplasty was performed as treatment of keratoconus.,0
In our experience it is better than single agent chemotherapy.,0
"The other two patients developed immune-related adverse events (irAEs) including rash (one case; grade 2) and diarrhoea (both cases; grades 1 and 2, respectively); the histopathology of colon biopsy samples from both was suggestive of colitis, with an abundant CD8+ T-cell infiltrate.",0
Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes.,1
"PDT was performed twice, but after the second cycle, patient developed choroidal ischemia and the visual outcomes were poor.",0
Radiation recall resolved spontaneously with withdrawal of gemcitabine.,0
"It is quite possible that vancomycin was the only culprit, but impossible to ensure with the available evidence.",0
"The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.",1
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
She had been receiving TPN for 2.5 years when she developed cholestasis which worsened despite adjustments to her TPN regimen.,0
"We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.",1
Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.,1
"Methadone, a synthetic opioid that is increasingly used for the management of chronic pain, has recently been implicated in the development of the prolonged QT syndrome.",0
"Clinical, histological and serological studies--a further 10-year follow-up.",0
"We describe a relatively healthy, 9-year-old boy who developed a CA-MRSA skin and soft tissue infection and was treated with TMP-SMX.",1
Further control studies assessing the efficacy and safety of antiandrogen agents are recommended.,0
A 71-year-old man presented with herpes zoster ophthalmicus and ocular involvement.,0
"At the third session of TACE, the right hepatic artery was found to be thrombosed; however, angiography also demonstrated collateral feeder vessels (arising from the pancreaticoduodenal artery) which were used for treatment.",0
Neurological improvement and rehabilitation potential following toxic myelopathy due to intrathecal injection of doxorubicin.,1
"A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.",1
An amiodarone optic neuropathy has been described.,1
Phase I and pharmacokinetic study of a novel mitomycin C analog KW-2149.,0
A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.,1
Puberty started at 11.2 years and menarche occurred at 12.7 years.,0
Improvement in her condition was evident 6 months after discontinuing amiodarone.,0
Milnacipran is a novel serotonin noradrenaline reuptake inhibitor.,0
"Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin.",1
There were no complications as a result of naloxone therapy.,0
METHODS: A case report of a patient with ovarian cancer extensively treated with platinum-based chemotherapy and aggressive surgery is presented.,0
"Because thrombolysis of giant thrombi may be ineffective, patients in this situation may require surgery.",0
Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.,1
Chemotherapy usually consisted of alkylating agents often given in high dose and for long durations.,0
This case highlights the possible development of acute coronary syndrome as a side effect of Capecitabine therapy.,1
The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril-induced acute renal failure.,1
Hospital records were reviewed when available.,0
We report a case of acute hyperphosphatemia secondary to rectal administration of sodium phosphate and sodium biphosphate (Fleet enema).,1
"An adult female with developmental disability was prescribed chlorpromazine for the target behaviors of aggression and self-injurious behavior (SIB), and she was prescribed phenobarbital for seizures.",0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.",1
"Treatment for up to 2 years with SMS controlled symptoms, suppressed serum gastrin, and suppressed acid secretion.",0
Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).,1
"Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.",1
"A 45-year-old woman and a 49-year-old man, both with a history of rheumatoid arthritis, were treated with etanercept and infliximab, respectively.",0
A 5-year-old girl was admitted due to severe asthmatic attack.,0
The incidence of this adverse effect in children and young adults who have cystic fibrosis is unknown.,0
"It produces clinically malignant multivesicular infiltrating lesions most often in the liver, and is quite different from the usual cystic variety caused by E. granulosus.",0
"Furthermore, the dystonia may resolve following the disappearance of the brainstem and thalamic lesions.",0
This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.,1
"All three children are still disease-free, after a mean follow-up period of 42 months.",0
"We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.",1
OBJECTIVE: This article discusses the management of an insulin dependent diabetic man aged 52 years presenting with 17 torso basal cell carcinomas (BCCs); mostly superficial BCCs (SBCCs).,0
We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.,1
Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.,1
In four patients corneal infiltrates cleared on topical medication.,0
"The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.",1
"To our knowledge, this is the first reported case of the use of sodium thiosulfate to treat calciphylaxis in a patient with normal renal function.",0
"However, adrenal suppression has only rarely been documented.",0
"This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy.",1
Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy.,1
"CASE DESCRIPTION: A 24-year-old 732-kg (1,610-lb) pregnant Belgian draft horse mare developed neuropathy and signs of intractable pain following colic surgery.",0
This adverse reaction is reported for the first time in a patient not concomitantly treated with other drugs associated with the appearance of priapism.,0
"An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.",1
"The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.",1
This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.,1
Coagulopathy associated with the use of cephalosporin or moxalactam antibiotics in acute and chronic renal failure.,1
"A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.",1
"Such agents include anthracyclines, taxanes and capecitabine.",0
"PURPOSE: To report a case of bilateral Acanthamoeba keratitis with late, atypical recurrence after penetrating keratoplasty a chaud.",0
"Nevertheless, the symptoms often go unrecognized and patients remain undiagnosed for years, not receiving the highly efficacious colchicine therapy; their histories often include multiple laparotomies, laparoscopies, and psychiatric evaluations.",0
CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.,1
Many women are diagnosed with early stage breast cancer each year who are potential candidates for adjuvant therapy.,0
There was no evidence of worsening of the myotonic symptoms.,0
Gentamicin-associated acute renal failure.,1
"We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections.",1
"Intralesional injection of corticosteroid is widely regarded as the treatment of choice for hemangiomas which induce strabismus or significant refractive error, or occlude the visual axis.",0
"The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.",1
"In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.",1
CONCLUSION: A scleral abscess should be suspected in a patient with endophthalmitis or microbial keratitis or both after a scleral-tunnel incision for cataract surgery.,0
"The infiltrate resolved in response to topical voriconazole, natamycin, and oral voriconazole.",0
OBJECTIVE: To report a patient developing fulminant liver failure while being treated with clarithromycin for pneumonia.,1
A case of contact dermatitis due to sodium bisulfite in an ophthalmic solution.,1
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.,1
CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.,1
He had never had any reaction from eating chocolate before and therefore reported this observation to his doctor.,0
"Neuroimaging in both diseases is characterized by large demyelinating lesions in the spinal cord extending over several segments, and/or in the brain often involving the locations of astrocytes water channels.",0
CONCLUSIONS: SD-OCT and AO detected abnormalities that correlate topographically with visual field loss from hydroxychloroquine toxicity as demonstrated by HVF 10-2 and may be useful in the detection of subclinical abnormalities that precede symptoms or objective visual field loss.,1
"The remaining deaths were non-MTX related, but all 5 autopsies showed some degree of cirrhosis.",0
"Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with ""familial seizure disorders"" may in fact have the long QT interval syndrome.",1
"CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.",1
"She was unresponsive to standard therapies, including racemic epinephrine and albuterol nebulizers.",0
"It is the most prescribed antineoplastic drug in the world, with approximately 10 million women-use-years of experience.",0
"This method precisely limits the exposure to methotrexate, allowing a therapeutic effect without complication even in those patients who exhibit methotrexate sensitivity.",0
"After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole.",1
"All-trans retinoic acid has revolutionized the treatment of acute promyelocytic leukemia, but this therapy is often complicated by the all-trans retinoic acid syndrome.",0
"In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.",1
"MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.",1
"A 77 year old male was referred with abdominal pain, jaundice and elevated transaminase levels.",0
Therapy was discontinued at a cumulative dose of adriamycin of 600 mg/m2.,0
Clinical trials are warranted to test these effects.,0
A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).,1
"The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred.",1
"We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.",1
BACKGROUND: Hydroxyurea is a cytostatic agent used to treat myeloproliferative disorders and long-term treatment is associated with mucocutaneous adverse events and nail hyperpigmentation.,1
Resolution of systemic hypertension and partial return of right renal function followed rapid thrombus dissolution.,0
"After analysis of the case, ruling out other possibilities and using the Naranjo probability scale, we found that there is a highly probable likelihood that the symptoms presented by our patient were secondary to his drug therapy.",0
Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).,1
We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.,1
It has multiple adverse effects including neurotoxicity.,0
"Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.",1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
Relentless growth and recurrence carry a poor prognosis.,0
Fatal acute tubular necrosis occurred in 1 patient in whom intravesical formalin was used to control massive persistent hemorrhage from radiation cystitis.,1
The probable additive toxicity of both agents on the pulmonary tissue is discussed.,0
"In this respect, tricyclics are analogous to several other drugs that are capable of modulating the frequency of oscillatory biological processes.",0
"Fifteen months after surgical resection and adjuvant chemotherapy, the donor had no evidence of recurrent tumor.",0
We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.,1
The authors caution that treatment with alprazolam may be complicated by the induction of mania.,1
Intraventricular nafcillin-induced seizures in a neonate.,1
"The efficacy and safety of fluticasone has been established at recommended doses of 200 micrograms/day, but not at higher doses that are often used.",0
High-dose methotrexate-associated acute renal failure may be an avoidable complication.,1
We present a case of postoperative nausea and vomiting resulting from a presumed lumbar CSF leak in a nonverbal child after surgical placement of a permanent intrathecal catheter.,0
Acute sensorineural hearing loss following intravenous ketoralac administration.,1
Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.,1
We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.,1
Mitoxantrone and cyclophosphamide in advanced breast cancer: a pilot study.,0
"In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.",1
"A retrospective review revealed that the patient had been exposed to iopamidol, an intravenous contrast medium, on the day prior to the commencement of methotrexate treatment.",0
Methyldopa-induced liver injury.,1
"Conversely, when rheumatoid arthritis (RA) is seen in association with HIV infection, remission of RA has been observed in some cases.",0
A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.,1
Recurrent hypotension immediately after seizures in nortriptyline overdose.,1
Antimalarial psychosis revisited.,0
She had undergone oral sex steroid therapy for long-term oligomenorrhea.,0
"The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.",1
The patient had been experiencing frequent headaches and tenderness at the site of the lump for about a month before being seen by the neurosurgeon.,0
"We, therefore, recommend a trial of HU for thalassemia intermedia patients in whom chronic transfusion therapy is being contemplated.",0
"Physicians should be aware of the presence of corticosteroids in over-the-counter products, that are not mentioned on the instruction leaflet.",0
DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.,1
A single case of encephalopathy and three cases of peripheral neuropathy are the only neurotoxicities reported.,0
"When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.",1
"On MRI, the low and high signal areas near the end-plate of L5/S1 were detected by T1- and T2-weighted imaging, respectively, and an abscess was noted around the cage.",0
The entire bezoar could be removed endoscopically.,0
Every year they receive dilated fundoscopic eye examination.,0
Zolpidem tissue concentrations in a multiple drug related death involving Ambien.,1
"Six months later, amiodarone treatment was reinstated due to life-threatening tachyarrhythmia; however, the patient remained euthyroid.",0
The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.,1
"Aluminum intoxication, along with other factors, was considered to be the cause of TC development.",1
Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.,1
"We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).",1
"RESULTS: Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score.",1
"The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.",1
"It is comprised by pain, discoloration, and edema in the vicinity of intravenous infusion of phenytoin through dorsal veins of the hand.",0
"In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.",1
Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma.,1
Subsequent serial electro- and echocardiograms were normal.,0
Both patients underwent cerebrospinal fluid shunting mainly for their hydrocephalus.,0
"Sprague Dawley and Brown Norway rats were ovariectomized and randomly assigned to treatment groups (subcutaneous implantation of either a capsule containing 20 mg 17beta-estradiol or an empty capsule, as a control).",0
"CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.",1
We describe a 53-year-old man with Churg-Strauss syndrome and subsequent opportunistic cytomegalovirus enterocolitis.,0
Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.,1
The elicitation of a movement disorder by trazodone: case report.,1
"She was transferred to our hospital after she developed pancytopenia, fever, and ileus.",0
Severe granulomatous inflammatory response induced by injection of polyacrylamide gel into the facial tissue.,0
Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.,1
We also discuss the possible role of protein S deficiency as a contributing factor.,0
The neurotoxicity was associated with oculomotor disturbances expressed primarily as weakness of convergence and divergence.,0
Neutropenic colitis during standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer.,1
He underwent uneventful cataract extraction surgery and intraocular lens implantation of the right eye.,0
"Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.",1
"Within 6 weeks, endophthalmitis resolved in three consecutive patients with positive aqueous cultures.",0
Incidence of myopathy in patients treated with antimalarials.,0
By comparing the length of the recurrence-free period following surgery alone with that following surgery plus perfusion in the same patients it was shown that perfusion treatment gave a significant extension of the recurrence-free time.,0
"Methemoglobinemia may occur in a number of drug or chemical ingestions, but a comprehensive review of the literature failed to identify a similar reported case.",0
"Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.",1
"In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate.",1
"Although heliox has been used foryears to treat patients with various respiratory complications, it is not currently a common treatment instituted by anesthesia practitioners for the treatment of bronchospasm.",0
"Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.",1
Mycophenolate mofetil is a novel immunosuppressive drug already established in transplantation medicine.,0
"Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.",1
Abnormally high urine and bone fluoride confirmed the diagnosis.,0
A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.,1
Methotrexate is an effective but potentially toxic treatment for psoriasis.,1
"We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy.",1
Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: a case report and review of the literature.,1
"In addition, not enough controlled clinical trials have yet been conducted.",0
The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis.,1
"She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.",1
"While peripheral neuropathy and cranial nerve involvement is common, optic neuropathy is extremely rare.",0
We report the case of a 51-year-old man in whom IFN-alpha treatment was followed by recurrence of Graves' disease 10 years after thyroidectomy was performed and the patient was declared cured.,1
"In each case, the decline in free SDC was temporally related to the resolution of digoxin toxicity; in one case, digoxin intoxication recurred and was associated with a rebound increase in free SDC.",0
Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.,1
"Three days after administration began, serum CPK levels had become markedly elevated to 10,897 mg/dl and myoglobinuria was detected (1,800 ng/dl), suggesting the presence of rhabdomyolysis.",0
"Cyclosporine is a potent inhibitor of simvastatin metabolism, and may therefore facilitate simvastatin-induced rhabdomyolysis.",1
We encountered a late pulmonary complication after umbilical cord blood transplantation (UCBT) that has not been previously reported.,0
"This article discusses the initial treatment attempted at resolving the bronchospasm, as well as the use of heliox in the ultimate resolution of the bronchospasm.",0
RESULTS: Topiramate was discontinued.,0
"After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.",1
"Moreover, the perforation occurred despite using a minimum concentration of the drug, risk factors were absent, and the surgery was performed by an experienced surgeon.",0
"CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.",1
This patient recovered after aggressive supportive therapy including intravenous alkali and fluid administration as well as continuous venovenous hemodiafiltration.,0
"Botulinum therapy was discontinued and nonsteroidal anti-inflammatory medication markedly reduced the new symptoms, which completely resolved within 3 months.",0
"Toxic manifestation includes myoclonus, ataxia, confusion and sudden death.",0
Systemic complications associated with retinal cryoablation for retinopathy of prematurity.,0
The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.,1
An unusual case of Candida tropicalis sepsis in a patient submitted to allogeneic bone marrow transplantation.,0
The low ionized calcium was unsuccessfully treated with several doses of calcium levulinate but successfully treated with 1 alpha-hydroxycholecalciferol.,0
Paclitaxel and CBDCA therapy was indicated as second-line chemotherapy in one patient and as third line in four patients with recurrent disease.,0
Nineteen cases of allergic contact dermatitis to compound tincture of benzoin are described.,1
Scrotal ulceration induced by all-trans retinoic acid in a patient with acute promyelocytic leukemia.,1
"Captopril-associated ""pseudocholangitis'.",1
Norethisterone and gestational diabetes.,0
Strict neurological supervision of patients treated with chlorambucil is recommended.,0
"Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described.",1
"A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.",1
"Chronic, low-grade endophthalmitis after cataract surgery with intraocular lens (IOL) implantation is often unresponsive to antibiotic therapy, probably because of low drug penetration into the capsular bag.",0
"Also, transcranial Doppler revealed approximate doubling of blood flow velocity in vertebral artery area compared with her baseline value.",0
Follow-up ECG showed improvement in ST-segment elevation and eventual resolution to pre-event tracing; cardiac enzymes showed slight elevations.,0
The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.,1
These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).,1
OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.,1
This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.,1
"To the best of our knowledge only two previous cases of AML have been linked to treatment of HCL with purine analogs, both with 2-chlorodeoxyadenosine.",1
We describe a case of intraoperative gelatine-induced anaphylaxis whose diagnosis was delayed as the use of gelatine during surgical procedures was omitted for two times in patient's medical records.,1
Reversal of ergotamine-induced arteriospasm by mechanical intra-arterial dilatation.,1
Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.,1
Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.,1
Asthmatic individuals are one of the higher risk groups suffering from dental erosion.,0
Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.,1
"Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.",1
DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases.,1
Vincristine induced cranial polyneuropathy.,1
"Several cases of nephrotic syndrome occurring after BMT have already been reported, but most cases had membranous nephropathy.",0
Iatrogenic Mycobacterium infection after an epidural injection.,0
"Two years later, his treatment was switched to olanzapine.",0
A 28-year-old man underwent pterygium excision with a single intraoperative application of mitomycin C (0.02%) for 3 minutes.,0
"Toxic streptococcal syndrome is characterized by fever, shock, multiorgan system failure and a desquamating scarlatiniform rash.",0
"In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.",1
Thrombolytic therapy in acute cerebral infarction complicating diagnostic cardiac catheterization.,0
Syndrome of inappropriate antidiuretic hormone associated with vinorelbine therapy.,1
Inflammatory cells were quantitated and compared with inflammatory cells in normal upper tarsal conjunctivae.,0
"Although she immediately improved following abortion (within 2 hr, peak airway pressure fell from > 70 to 38 cmH2O, without change in plateau pressure), superimposed morbidities improved more slowly, and the patient made a complete recovery.",0
"Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.",1
Amphotericin B nephrotoxicity in humans decreased by salt repletion.,1
This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.,1
"The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose.",1
Radiography disclosed a lumbosacral intradural tumor.,0
DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.,1
Diagnosis may be confirmed by CT-scanning of the orbits.,0
"We report a case of severe anemia, which responded well to steroid therapy, in a patient receiving IL-2 plus IFN-alpha for metastatic renal cell carcinoma.",1
These cases highlight the occurrence of livedo reticularis as an uncommon side-effect of interferon alpha treatment.,1
"Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.",1
"His electrocardiogram revealed minor abnormalities, including a prolonged QT interval.",0
Optic neuropathy associated with penicillamine therapy in a patient with rheumatoid arthritis.,1
Reversible sirolimus-associated pneumonitis after heart transplantation.,1
"The results of our investigation were inconclusive, but suggested that the endoscope could have been responsible for some of the cases.",0
Only one death has been recorded in the responding group.,0
Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.,1
Photo-onycholysis caused by olanzapine and aripiprazole.,1
The purpose of this study was to examine the incidence and cause of Clostridium difficile colitis occurring after cisplatin-based combination chemotherapy in ovarian cancer patients.,1
The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.,1
"METHODS: Two patients with long-term hydroxychloroquine use, subtle perifoveal ophthalmoscopic pigmentary changes, and bilateral perifoveal defects on automated Humphrey visual field (HVF) 10-2 perimetry were imaged using SD-OCT and AO.",0
On chronic pain assessment he was having hyperalgesia to light touch in addition to the spontaneous chest pain.,0
Aripiprazole-induced hiccups: a case report.,1
Kaposi's sarcoma in the setting of immunosuppression and the gastrointestinal manifestations of this disease are reviewed.,0
Prolongation of the QT interval and ventricular tachyarrhymias have been described in patients on amiodarone therapy.,1
Serotonin syndrome caused by interaction between citalopram and fentanyl.,1
"Fever was a constant finding, frequently accompanied by signs of central nervous system dysfunction.",0
An extensive literature search revealed few previous reports of herbal drug induced EM and SJS.,0
Renal failure associated with the use of dextran-40.,1
"Extremely high exposures in an obese patient receiving high-dose cyclophosphamide, thiotepa and carboplatin.",0
"The addition of certain substrates such as glutamine, arginine and omega-3 fatty acids may improve the body's immune response as well.",0
We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.,1
"We propose a common mechanism: the vasoconstrictors caused systemic hypertension, increased left ventricular afterload, decreased left ventricular compliance, and decreased cardiac output.",0
"Most antidepressants and also antipsychotics are metabolized by the polymorphic debrisoquine/sparteine hydroxylase, i.e., cytochrome P450 (CYP)2D6.",0
The improvement in initiative and social capacity was striking and appeared to be due to improved awareness of the environment and the acquisition and handling of useful knowledge.,0
Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management.,1
It would seem that some travelling roots of the sympathetic nerve were preserved from the chemical neurolysis and the remaining efferent and afferent nerve fibers were responsible for the persisting low frequency HAR wave and pain in the left leg.,0
A case report.,0
"In the other patient, a 78-year-old woman, Neisseria mucosa knee arthritis occurred after a single sodium hyaluronate injection.",1
Both syndromes are mostly related with drugs.,0
The patient had already been on methimazole for a month when she was admitted to the Pediatric Unit with the diagnosis of sepsis.,0
Although this G-CSF-driven leucocytosis was alarming it did not appear to have adversely affected the patient's prognosis.,1
Pulmonary fibrosis is a complication of paclitaxel therapy that may occur despite treatments with corticosteroids.,1
"Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.",1
This complication may have been due to shrinking of the tumor as well as thrombocytopenia following chemotherapy.,0
"A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.",1
The treatment of amputee residual limb pain can at times be a challenge for the physician.,0
"Conventional brachytherapy can reduce these problems, but its use is limited in young children because of radiation exposure to parents and care-givers.",0
"In general, it is good medical practice to avoid concomitant administration with centrally acting anticholinergic agents.",0
"Allergic side effects of AZA are rare, and reported allergic skin eruptions from AZA are very limited in Japan.",1
The possible mechanisms for this complication in out patient are discussed.,0
The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.,1
Suicide associated with corticosteroid use during chemotherapy: case report.,0
"A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.",1
Comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine.,0
"The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.",1
"The AUC was between 0 and 6 X 10 ng X min/ml, and AUC normalized to 1 mg/m2 of 6MP was between 0 and 815 ng X min/ml.",0
A primigravid woman presented at 11 weeks gestation with bilateral femoral occlusive thrombi extending above the renal veins.,0
Suxamethonium apnoea terminated with commercial serumcholinesterase.,1
"Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning.",1
"Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.",1
The patient expired 13 d after admission.,0
CONCLUSIONS: This case illuminates a possible role of UV therapy in the induction of pemphigus herpetiformis through an epitope-spreading mechanism.,0
Experience with five patients in whom impaired renal function developed early during amphotericin B therapy is reported.,1
A dermatologist diagnosed this as Sweet's syndrome caused by G-CSF; consequently G-CSF administration was stopped.,0
"A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery.",1
"A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.",1
"All three achieved complete remission, although one patient relapsed.",0
"Six patients had bacterial pneumonia, one had acute cholecystitis, and none had a previous history of heart disease.",0
"The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.",1
"Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.",1
CONCLUSION: Catheter failure is a common cause of intrathecal drug delivery problems and may be difficult to diagnose.,0
The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.,1
"Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.",1
"After 1 week, HPA axis function was markedly improved.",0
Conversion to another immunosuppressant seems to be an appropriate procedure in this condition.,0
Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.,1
"We describe a technique for 'single-pass' shunt tunneling from frontal to abdominal incisions and our initial results in a consecutive, prospective series of 15 children (age 2 days to 5 years).",0
Patients receiving therapeutic immunosuppression for organ transplants have also reported to suffer from aspergillus osteoarthritis.,0
"A 12 year old patient with atrial flutter is presented, in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia.",1
Severe autoimmune myasthenia gravis is difficult to manage and may require immunosuppression with cyclosporine.,0
"All patients received heparin for insertion, and in three patients, heparin was reversed with protamine.",0
In vitro lymphocyte transformation studies confirmed cross-reactivity to one or more aromatic AEDs in 3 patients.,0
"We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.",1
"In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.",1
"A review of the literature suggests that leukoencephalopathy may be prevented by high doses of leucovorin and can be treated by high doses, if lower doses were used initially.",0
Three cases of acute renal toxicity in patients receiving long-term therapy with mitomycin C and 5-fluorouracil are reported.,1
"CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.",1
"Without other causes for the hyponatremia, she was diagnosed with the syndrome of inappropriate antidiuretic hormone, presumably caused by desmopressin.",1
The thrombus occupied almost half the right atrial cavity and hit the tricuspid valve with each heartbeat without obstruction of tricuspid inflow.,0
"Four recovered fully within 24 h, two recovered partially after 24 h and completely after 48 h while two recovered only after 72 h.",0
Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values.,1
Chromosomal analysis showed some abnormalities.,0
It is concluded that SIADH is an important side effect of lorcainide therapy.,1
Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.,1
Can magnesium sulfate therapy impact lactogenesis?,1
She has persistent proteinuria and is currently undergoing a trial of high-dose steroid therapy.,0
During PUVA treatment a 66-year-old woman with mycosis fungoides in stage III suddenly developed widespread papulonodular lesions of alarming clinical and histological appearance.,0
"After several days of heparin therapy, the dialyzer circuit thrombosed and the platelet count decreased to 82 x 10(3)/mm(3).",0
"Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have been previously reported in patients with depression and obsessive-compulsive disorder (OCD).",1
Cyclophosphamide (CP) is an alkylating agent widely used in treating cancer and autoimmune disease.,0
Diazepam use by pregnant women can be associated with a later presentation of withdrawal symptoms in the neonate than that induced by the use of other drugs.,1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
"After appropriate antibiotic and replacement of the central venous line, CT demonstrated disappearance of the lung nodules in all three patients, enabling a diagnosis of nodular septic embolism.",0
"We observed a patient who developed a maculopapular rash 48 h after beginning oral therapy with this drug, and 2 days later, angioedema and hypotension.",0
"OBJECTIVE: To test the efficacy and safety of a nicotinic, acetylcholine antagonist, mecamylamine, in the treatment of Tourette's syndrome (TS).",0
CONCLUSION: Alendronate led to nodular scleritis and rechallenge caused recurrence of scleritis.,1
Rapid onset of quetiapine-induced diabetic ketoacidosis in an elderly patient: a case report.,1
"After returning to a normal level of greater than 100,000/mm3, the patient's platelets again dropped to 1200/mm3 with readministration of rifampin.",0
There was complete radiological and clinical resolution of the abscess on prolonged treatment with amphotericin alone.,0
"A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.",1
"Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.",1
"The 5 neonates with antral hyperplasia had received prostaglandin E1 for longer periods (mean [+/- SD] duration, 569 +/- 341 hours) than the 65 normal neonates (54 +/- 58 hours, P less than 0.001) or the 4 neonates with clinical signs of gastric obstruction (119 +/- 60 hours, P less than 0.05).",0
The reflex myoclonus had a 150-ms refractory period.,0
Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.,1
"In addition, we emphasize the need for informed consent when facing factors that predispose to bleeding (esophageal varices, coagulopathy and thrombocytopenia), possible band ligation before the start of sorafenib, careful clinical monitoring and discontinuation of sorafenib when major bleeding occurs.",0
Successful intervention is seldom reported.,0
Two other cases of shunt infection during the same time period were treated for only 2 days with intraventricular vancomycin and did not manifest CSFE.,0
These symptoms were reproduced after a second administration of brimonidine.,0
We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.,1
"After 2 weeks, visual acuity was better and improvement was evident on topography, pachymetry, and slitlamp photography.",0
"We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).",1
"Consequently, intravenous salmon calcitonin was administered, based on evidence of efficacy in the treatment of other neuropathic pain syndromes and its relatively benign side-effects profile.",0
We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).,1
Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.,1
CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.,1
"The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.",1
A second challenge while the patient received all fluids and electrolytes intravenously again resulted in decreased serum sodium concentration (134 to 126 mEq/L) after urinary loss of only 69 mEq of cation.,0
"Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.",1
"The glial abnormality, the most striking feature in the present case, strongly suggests toxic and metabolic disturbances.",0
Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.,1
"Two patients were found not to be sensitive and started on aspirin, the other had a classic asthmatic reaction to the drug and was successfully desensitized to aspirin allowing for its use.",0
The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.,1
Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.,1
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.,1
Secondary hematologic neoplasm after intravesical chemotherapy for superficial bladder carcinoma.,0
We present a unique case of GTBM in a patient with myeloma following treatment with Melphalan.,1
"Tc-99m labelled Anti CD 66 monoclonal antibody imaging is a useful, noninvasive approach to the assessment of bone marrow reserve under such circumstances.",0
No recurrence was seen during the follow-up period (3 and 4.5 years).,0
Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.,1
Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.,1
"A case of skeletal fluorosis induced by prolonged treatment with niflumic acid, a fast-acting non-steroid antiinflammatory agent, is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated, in addition, with corticosteroids.",1
Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.,1
"Cannulation of the radial artery can result in complications ranging from arterial thrombosis, arterial aneurysm, compartment syndrome, infection, nerve injury and skin necrosis to possible thumb or even hand necrosis if not recognized and treated early.",0
"Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.",1
"High-resolution computed tomography scan findings were consistent with ILD, which was sufficient to diagnose as erlotinib-induced ILD.",1
Fatal digoxin poisoning: an unsuccessful resuscitation with use of digoxin-immune Fab.,1
"Although isoproterenol has been the mainstay of therapy for chronotropic support in this setting, its availability has been an issue in recent years.",0
A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.,1
Management of cryptococcosis and toxic epidermal necrolysis in a dog.,0
A fatal case of theophylline intoxication is presented in which a number of factors leading to a decrease in theophylline clearance and the patient's death were possibly operative.,0
CONCLUSIONS: Metoclopramide may cause reversible nonthrombocytopenic vascular-type palpable purpura.,1
Cutaneous side effects caused by interferon are well known.,0
"In one case, the readministration of riluzole was followed by the relapse of hepatitis.",1
"Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.",1
"CONCLUSIONS: These results suggest that clozapine may cause TD; however, the prevalence is low and the severity is relatively mild, with no or mild self-reported discomfort.",1
"His lung cancer recurred 10 months later, when he was found to have bone metastases.",0
This may be particularly useful in patients unable to tolerate an alternative class of antihypertensive agents.,0
"Intravenous hydration with normal saline was initiated as the patient had normal kidney function, and urinary output was monitored.",0
"RESULTS: The number of days each patient received mecamylamine varied from 8 days to 550 days; with nine patients more than 200 days, six patients from 100-200 days, five patients for 50-100 days, and four patients 0-50 days.",0
We describe a case of pneumonitis following local administration of methotrexate for nonsurgical termination of an ectopic pregnancy.,1
"The combinations of clinical manifestations among FMF patients are quite heterogeneous, but our American cohort did not establish any connections between individual mutations and specific clinical pictures--as is seen in other diseases like cystic fibrosis, in which distinct genotypes target certain organ systems.",0
"Combination therapy with i.a. urokinase, i.a. prostaglandines and i.v. anticoagulation resulted in re-opening of the obstructed distal artery and complete cessation of symptoms.",0
She was discharged with oral levofloxacin to complete an additional 3 days of treatment as an outpatient.,0
Earlier recognition and treatment may lead to improved outcome.,0
The possible development of a drug-induced vasculitis or lupus-like syndrome should be added to the list of rare toxic effects of vancomycin.,1
We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.,1
"Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.",1
"In 25 patients in whom ectopy persisted despite drug therapy, there were 17 sudden deaths.",0
"One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).",1
Gastric outlet obstruction due to an iatrogenic cause in a neonatal period - report of two cases.,0
After operation they developed arterial hypotension that failed to respond to epinephrine (adrenaline) or dobutamine treatment.,0
"It is suggested that cholestyramine, by reducing vitamin D absorption, precipitated the rapid development of osteomalacia in this patient.",0
Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).,1
"As judged from the clinical course of this major surgery, recombinant FVIIa appears to be highly efficacious and safe and should be used as first line treatment in high titre inhibitor patients with cross-reactivity to porcine factor VIII, undergoing surgery.",0
Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.,1
A 51-year-old male with a huge chondrosarcoma received subarachnoid dorsal root blocks with 10% phenol in glycerine to treat severe pain along the left leg.,0
We present an AIDS patient with severe and prolonged lactic acidosis on stavudine and lamivudine.,1
"This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.",1
Thrombolytic therapy may be a two-edged sword and therefore early angiography should be considered in making the diagnosis and choosing the therapy.,0
Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.,1
Chronic inflammatory demyelinating polyneuropathy associated with tumor necrosis factor-alpha antagonists.,0
"On the second day of hospitalization, it was noted that the patient's dyspnea and sinus bradycardia could be related to a recent increase in his timolol dosage.",1
PURPOSE: To describe spectral-domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging in hydroxychloroquine retinal toxicity.,1
Sensation of all modalities was intact.,0
CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.,1
Umbilical artery catheterization is often performed in critically ill neonates.,0
Penicillin-induced Jarisch-Herxheimer reaction.,1
A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement.,1
Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.,1
Paecilomyces lilacinus infection in a liver transplant patient: case report and review of the literature.,0
The occurrence of this reaction in a mother and daughter on ingestion of tuna fish is reported.,0
Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide.,1
"A 12 year old patient with atrial flutter is presented, in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia.",1
Dissolution of pancreatic stones by oral trimethadione in patients with chronic calcific pancreatitis.,0
CONCLUSION: Linezolid seems highly active in combination treatment of MDR-TB.,0
All three patients had rheumatoid arthritis and had received chloroquine for between 12 and 18 months with a maximum dose of 250 mg/daily.,0
"Cerebral angiography disclosed occlusions and narrowing of both internal carotid arteries at the supraclinoid portions, where multiple cysts were found on the MRI.",0
The patient survives with severe sequela which confirms slow progression as typical in nonAIDS cases.,0
"However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.",1
Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.,1
Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.,1
"The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.",1
"We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.",1
We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.,1
Macular infarction after endophthalmitis treated with vitrectomy and intravitreal gentamicin.,1
"Unfortunately, while there are numerous observational reports in the literature, there is not a lot of information concerning the safety and efficacy of particular treatments or the nontreatment of bipolar disorder during pregnancy.",0
Clozapine was approved by the U.S.,0
The severity of the haemorrhagic diathesis prompted us to describe the case in order to draw the attention of medical personnel to the dangerous potentiation effects of different drugs administered with vitamin K antagonists.,0
"Within days, she developed paranoid ideation, profound psychomotor retardation, increased depression, and fatigue.",0
"To the best of our knowledge, this is the first case report of pelvic dyskinesia with good evolution and control of dyskinesias after treatment with tetrabenazine.",0
These three cases illustrate the diagnostic and therapeutic overlap between childhood and adult anxiety disorders and indicate the need for empirical studies aimed at evaluating diagnostic and treatment issues in childhood anxiety disorders.,0
"Sodium phenylbutyrate was added to treatment with HU in two patients, but failed to produce an increase in total Hb despite increasing Hb F levels.",1
Comparing his coronary angiograms with those obtained before surgery indicated a severely spastic left coronary artery.,0
"However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.",1
The effect of regional perfusion treatment on recurrent melanoma of the extremities.,0
"One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).",1
OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.,1
"He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.",1
Oral hairy leukoplakia in nonimmunosuppressed patients.,0
"A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.",1
"Microscopic examination of a skin scraping revealed a heavy infestation of cheyletiella yasguri, as identified by the presence of hoks of the palpi and the heart-shaped sensory organ on genu I.",0
Severe hepatitis caused by cyproterone acetate.,1
Acetazolamide (Diamox) is a carbonic anhydrase inhibitor commonly used in patients with glaucoma in order to reduce intraocular pressure.,0
All biopsies were studied by the same pathologist.,0
BACKGROUND: Methotrexate (MTX) is a folic acid antagonist used in high doses as adjuvant chemotherapy for osteosarcoma.,0
A case of necrotizing fasciitis of the vulva arising in a leukemic patient during a chemotherapy nadir is presented.,0
Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.,1
PURPOSE: To report a case of Acanthamoeba infection following LASIK.,0
"In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.",1
The clinical symptoms were associated with pronounced (CD4) lymphopenia and a marked increase in serum immunoglobulin A levels.,0
We report the first histopathologically documented case of oral mucosa pigmentation after OLP treatment with topical tacrolimus.,1
Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.,1
"The patient's medications before admission included quinidine, isosorbide dinitrate, dipyridamole, aspirin, pilocarpine eyedrops 4%, timolol eyedrops 0.5%, and nitroglycerin ointment and sublingual tablets.",0
"Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.",1
"Therapeutic options to treat this dangerous imbalance comprise calcium gluconate, insulin plus glucose, albuterol/salbutamol inhalation.",0
Radiation-induced fibrosis (RIF) is a terminal sequela to irradiation that does not regress spontaneously.,0
"METHODS: The number of reports received, age and sex of the reporters, characteristics of the most frequently reported drugs and characteristics of the ADRs (most frequently reported ADRs, seriousness, outcome) in a 3-year period (April 2004-April 2007) were compared between patient reports and reports from healthcare professionals.",0
Patients with cell-mediated immune defects are at higher risk for acquiring infections with Salmonella species.,0
"Two patients received 6 mg sumatriptan subcutaneously on days 4 and 6, and one patient 3 x 100 mg sumatriptan orally on day 1 after an acute headache episode.",0
Report of three cases and review of literature.,0
Phenobarbital hepatotoxicity in an 8-month-old infant.,1
Moxalactam is more likely to be associated with platelet dysfunction.,1
Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA).,1
Drug interactions and neutralizations as well as dietary factors contributed to a complicated course.,0
"METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.",1
"Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.",1
Probable enoxaparin-induced hepatotoxicity.,1
This proved to be extensive forearm deep venous thrombosis.,0
The location and extent of the central nervous system pathology correlated with the type and severity of clinical symptoms.,0
"Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.",1
Pulmonary GVHD and pulmonary aspergillosis were also observed.,0
Fluorescein angiography confirmed leakage surrounded by central serous detachment of the retina.,0
"Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.",1
"DISCUSSION: In general however, it must be remembered that problems with oral hypoglycaemics are rare.",0
No patients died.,0
"In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.",1
CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.,1
Severe corneal toxicity after topical fluoroquinolone therapy: report of two cases.,1
Toxic optic neuropathy associated with ethambutol: implications for current therapy.,1
"Despite vigorous therapy, severe hypoventilation and hypoxemia persisted with mechanical ventilation.",0
We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).,1
"We are reporting on a ""very-very"" late stent thrombosis that occurred 43 months post-implantation.",0
PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.,1
"The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease.",1
"The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.",1
The ampicillin rash occurring in cases of infectious mononucleosis is well documented.,1
The endoscopic and histological features were consistent with the diagnosis of ischaemic colitis.,0
"This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.",1
The incidence and clinical features of allergic contact and/or photocontact dermatitis due to psoralens were examined in 371 patients with psoriasis treated with topical PUVA.,0
Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.,1
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.,1
In two of the patients there appeared to be a correlation between the severity of the psoriasis and the dosage of interferon.,0
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
"Full recovery occurred because of early pick up, emphasizing the need for careful fluid balance monitoring of patients receiving cisplatin chemotherapy.",0
"HMSN is diagnosed in most cases retrospectively, usually suggested by the observation of foot abnormalities or family history.",0
"Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.",1
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
"Endodontic treatment, when possible, rather than extraction is the treatment of choice in patients suffering from such a disease.",0
Valproic acid induced coma is presented in an adult patient without a history of metabolic disease.,1
"The ""pinch-off sign"" was noted on a routine chest X-ray but that was ignored.",0
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.,1
Neurological diseases have been rarely described as adverse events of anti-TNF agents.,0
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
Photosensitive reflex epilepsy is provoked by environmental flicker stimuli.,0
"We also strongly draw the attention to the main preventive procedure against invasive fungal infection that is the correct management of antidiabetic therapy that prevents the predisposing temporary neutrophils activity deficit, contributing to a better survival rate of diabetic children.",0
"On the 16th day of therapy, however, relative eosinophilia developed, and 2 days later a pruritic maculopapular rash appeared.",0
"Following the first episode, he was eucalcemic for nine weeks without therapy, attesting to the prolonged biological effects of calcitriol when used in the treatment of hypoparathyroidism.",0
"We report a series of three patients with HCC and platelet count < 60,000/mm(3) who were successfully treated with sorafenib with no complications.",0
Severe symptomatic hyponatremia during sibutramine therapy: a case report.,1
"Although gemcitabine-based regimens have clear efficacy in refractory lymphoma, prior mediastinal radiation without subcarinal blocking may be a relative contraindication, especially in the presence of pericardial abnormalities on echocardiography.",0
L-Carnitine supplementation has been recommended to prevent the fatal hepatotoxic effects associated with valproic acid.,1
"Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.",1
He also experienced improvement in his pain control.,0
DISCUSSION: The Naranjo probability scale indicated a probable relationship between sertraline treatment and the onset of rhabdomyolysis.,1
"We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.",1
She had precordial ST-segment elevation characteristic of acute myocardial infarction and elevated cardiac biomarkers.,0
"Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.",1
"When the morning count of WBC began to fall, WBC count was repeated in the afternoons.",0
"She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.",1
Inhibition of cytochrome P450 seems to be an important mechanism.,0
"Decreased clearance of the compound has been observed in patients with renal insufficiency, and this has been associated with an increase in the ratio of morphine-6-glucuronide to morphine.",0
This patient was previously well with no known cardiovascular risk factors.,0
"RESULTS: Similar to previous findings of drug-induced vortex keratopathy, atovaquone vortex keratopathy is presumably caused by its lipophilic properties.",1
Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.,1
"Here, we present illustrative case histories to educate the reader on evaluation and management of this complex syndrome.",0
"RESULTS: Ethambutol, and to a lesser extent isoniazid, are both implicated in the development of visually related side effects.",1
RESULTS: Oral administration of the beta-blocker propranolol resulted in clinical and echocardiographic improvement of the left ventricular outflow tract obstruction.,0
No respiratory symptoms appeared in the ten patients who were given less than 950 mg/m2.,0
A 40-year-old man had undergone instrumented posterior lumbar interbody fusion at the L5/S1 level approximately 1 year previously.,0
Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.,1
Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.,1
"In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.",1
"Sister chromatid exchanges (SCEs), a sensitive measure of chromosome damage, were counted in peripheral-blood lymphocytes from 10 patients with Behcet's syndrome receiving chlorambucil.",0
It also shows severe relapse after withdrawal of fenclofenac.,0
CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.,1
"Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.",1
"Although activated clotting time (ACT) monitoring is encouraged to verify the adequacy of anticoagulation during the procedures, this is not a common practice in many laboratories.",0
Unexpected and prolonged akinesia: a case report.,0
"During attempted conversion from aripiprazole to clozapine, the patient experienced a significant reduction in psychiatric features.",0
The latter was discontinued slowly over a period of 10 weeks.,0
"We report the case of a patient with the acquired immunodeficiency syndrome treated with rifampicin who had a 'normal' screening test for adrenal insufficiency, yet had clinical evidence of adrenal failure.",1
"After both patients gave informed consent, an uneventful intravitreal injection of 1.25 mg Avastin was performed in the left eyes.",0
We conclude that the use of hemopoietic colony stimulating factors might be a suitable means to achieve the correction of severe thionamide-induced hematologic adverse reactions.,0
"Five and one-half years after the diagnosis of myeloma, while in remission on cyclophosphamide therapy, the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma.",1
"Joubert syndrome is a rare autosomal recessive disease characterized by hypotonia, ataxia, episodic hyperpnea, psychomotor retardation, abnormal ocular movements, cerebellar vermian hypoplasia, and molar tooth sign on magnetic resonance imaging.",0
"Six days after discontinuation of the drug, central nervous system symptoms had resolved, and, 4 days later, renal function returned to pretreatment values.",0
Topical capsaicin as an adjuvant analgesic for the treatment of traumatic amputee neurogenic residual limb pain.,0
"The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.",1
Laboratory investigations for uveitis were negative and the patient required systemic and intensive topical steroids with cycloplegics to control the inflammation.,0
"Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour.",1
"Also, he developed similar signs and symptoms when he was administered tobramycin intravenously on one occasion at 5 1/2 years.",0
"Starting with high-dose methylprednisolone treatment followed by defibrotide maintenance therapy the patient showed dramatic complete response of VOD, resulting in a normal sonography of the liver and normalization of laboratory values.",0
Involution of endophytic optic disc hemangioma with a single session of photodynamic treatment.,0
"Post-transplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV) and characterized by fever, lymphadenopathy, and graft dysfunction.",0
We found TPO and platelet responses to be generally antagonistic through all cycles.,0
"We treated her hyperthyroidism with amiodarone (average daily dose, 200 mg) for 3 weeks, achieving rapid and persistent euthyroidism, (triiodothyronine [T(3)] levels ranged between 64 and 109 ng/dL) without side effects.",0
BACKGROUND: Aggressive skin cancers on the cheeks may involve the parotid duct.,0
"The authors describe their use of midodrine in a dialysis patient for the longest period of time reported up to now, documented by a pharmacokinetic study, confirming long-term both clinical efficacy and safety of the drug.",0
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
We recommend the cautious use of alum irrigation in patients with renal impairment and monitoring of serum aluminum levels to prevent excessive accumulation and toxicity.,0
"An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.",1
A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.,1
Several possible explanations of the mechanism of renal failure associated with the use of dextran-40 are discussed.,1
Sporadic rippling muscle disease unmasked by simvastatin.,1
Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.,1
"After withdrawal of ibopamine and under continuation of all other concomitant medications her body weight continued to decrease during the following few days, her symptoms were alleviated and she was discharge to a nursing home.",0
Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.,1
"Since both hypothyroidism and iron deficiency anemia may coexist, additional thyroid function testing is recommended in patients treated concurrently with ferrous sulfate and L-thyroxine.",0
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
The 69-year-old patients recovered rapidly after oral administration of fluids and sodium bicarbonate.,0
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).,1
"CONCLUSIONS: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.",1
Postoperative imaging did not disclose any intra-orbital abnormalities.,0
"Urinalysis revealed eosinophils, and a subsequent renal biopsy confirmed a diagnosis of AIN.",0
"Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.",1
Pseudomembranous colitis readily occurs in at least certain population groups receiving trimethoprim-sulfamethoxazole.,1
Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.,1
RESULTS: The patient was seen on the eighth postoperative day with endophthalmitis that responded to medical treatment.,0
Acute coronary syndromes can be associated with the infusion of rituximab.,1
Electron microscopic examination of the heart revealed changes characteristic of adriamycin cardiomyopathy.,0
"An effective schema for the treatment of tardive dyskinesia includes avoiding antiparkinsonian medication and prescribing deanol, an acetylcholine precursor, while continuing or increasing phenothiazine dosages.",0
"Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.",1
Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.,1
"As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.",1
PURPOSE: The purpose of this study was to evaluate the differential diagnosis of pulmonary nodules by conventional radiography and computed tomography (CT) in osteosarcoma patients with central venous catheter.,0
"The hepatotoxicity is probably due to (-)-epigallocatechin gallate or its metabolites which, under particular conditions related to the patient's metabolism, can induce oxidative stress in the liver.",0
"The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.",1
"We recommended debridement as treatment; however, he refused further surgical intervention by reason of symptomatic remission.",0
"The administration of ""sweet spirits of nitre"" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.",1
We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).,1
Hypercoagulability studies were negative.,0
"In any patient with 'unexplained' muscle spasms or convulsions, strychnine poisoning should be included in the differential diagnosis and they should be asked about the use of herbal medicines.",0
"Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.",1
Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension.,1
Ventriculo-peritoneal shunting led to complete reversal of hydrocephalus with progressive disappearance of the acute encephalopathy.,0
A renal biopsy specimen on hospital day 9 showed tubular damage with minimal glomerular changes consistent with a diagnosis of nonsteroidal agent-induced nephropathy.,0
"In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.",1
"CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.",1
"We report a case of a 72-year-old female who presented with hemoptysis, cough, and dyspnea.",0
Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.,1
"Agranulocytosis is a disorder characterized by a severe decrease in the number of granulocytes in blood, that frequently occurs as an adverse reaction to some drugs.",0
We report a patient who experienced LABD shortly after starting carbamazepine therapy.,1
"Hypersensitivity to carboplatin has been reported in up to 44% of patients receiving this antineoplastic agent, usually occurring after several courses of treatment.",1
Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.,1
"CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.",1
CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.,1
"To the authors' knowledge, there is a paucity of published accounts of management of radiation-induced optic neuropathy (RION) by optic nerve sheath fenestration (ONSF) in the conventional medical literature.",0
"A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.",1
High-dose methotrexate is used in malignant hemopathies and solid tumors in children.,0
"BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.",1
CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.,1
"Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.",1
"We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.",1
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
"Two months after the transplant she developed an interstitial pneumonia: bronchoalveolar lavage yielded cytomegalic cells with intranuclear bodies, and cytomegalovirus DNA was detected by in situ hybridization techniques.",0
A patient receiving long-term corticosteroid therapy for asthma had two episodes of Pneumocystis carinii pneumonia (PCP) 8 years apart.,0
"Therapy with phenytoin, phenobarbital, valproic acid, and methylphenidate was unsuccessful.",0
"Serum testosterone, dihydrotestosterone and estradiol fell to castration levels 4-6 weeks after the initiation of treatment and remained low throughout the study period.",0
We report a case of simultaneous brain tuberculomas and scrofuloderma occurring in the same patient.,0
"After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.",1
Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin.,1
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
Corneal edema recurred when the administration of amantadine was resumed.,1
"Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have been previously reported in patients with depression and obsessive-compulsive disorder (OCD).",1
Corticosteroid therapy is a rare but possible independent predisposition to PCP.,0
The embolization of a venous catheter fragment is a rare complication.,0
"However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.",1
"Irritative skin reactions were observed only at higher testings doses, in contrast to the allergic type of reaction, which occurred at a lower testing dose.",0
A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor.,1
"Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.",1
"We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.",1
The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.,1
Glucagon is considered the drug of choice for treating bradycardia and hypotension encountered during beta-blocker poisoning.,0
Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.,1
Fatal intoxication using amantadine and pramipexole in a uremic patient.,0
Sexual dysfunction associated with intrathecal baclofen use: a report of two cases.,1
Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.,1
Encephalopathy and death may occur.,0
"A review of the literature, which yielded 23 other reports of endocarditis due to this organism, suggests that Lactobacillus is a rare cause of endocarditis.",0
"In addition, the patient tolerated other neuroleptics that were started in the hospital after the suspected NMS episode.",0
"Patients receiving amifostine who develop only fever should be evaluated for an adverse drug reaction, as well as for sepsis and fevers of neutropenia, and it may be necessary to discontinue the drug.",1
2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.,1
"After several unrevealing medical work-ups, he was found to have a high blood lead level (122 microg/dL); he has a history of scraping and sanding lead paint without adequate protective measures.",1
Clomipramine was tapered and reduced to 50 mg over a period of 10 days.,0
She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.,1
Clozapine-induced akathisia in children with schizophrenia.,1
"Unlike the persistently elevated serum HBV DNA level, the serum ALT and AST levels have gradually decreased.",0
A 74-year-old man who had been diagnosed with malignant mesothelioma developed malignant lymphoma of B-cell origin involving the penis.,0
Similarities to dinitrochlorobenzene (DNCB) are pointed out.,0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
Her systemic therapy was initiated at a time when her tumor burden was possibly relatively low and a good response to the aggressive combination chemotherapy including Daunomycin was obtained.,0
"The immunosuppressive regimen consisted of tacrolimus, mycophenolate mofetil, and prednisone.",0
Acute aluminum toxicity after continuous intravesical alum irrigation for hemorrhagic cystitis.,1
"After initial parenteral vancomycin and rifampin followed by oral prystinamycin-rifampin, the patient recovered without any sequelae.",0
Her symptoms regressed after inhaler steroid treatment.,0
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
DISCUSSION: Drug-induced LABD is a variant of classic or idiopathic LABD.,0
Patients must be instructed to recognize early symptoms of this severe infection and call the surgeon immediately.,0
The presence of a lymphocyte alveolitis with a predominance of CD4+ T cells in 3 RA patients and CD8+ T cells with a concomitant increase in neutrophils in another case suggests that immunologically mediated reactions may be one damage mechanism in MTX-induced pneumonitis.,1
"Experience with continuous haloperidol infusions is growing, and it appears to be an effective method for control of severe agitation or delirium.",0
P. falciparum can be transmitted in a hospital environment from patient to patient by blood inoculum if standard precautions are breached.,0
"Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with ""familial seizure disorders"" may in fact have the long QT interval syndrome.",1
Here we report our experience with BC infection in four patients with acute leukemia or related disorders.,0
This was later recognised to be a spurious effect due to the introduction of tolmetin.,0
Other practolol related side effects are usually present in the patient.,0
Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.,1
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
"INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.",1
"This can occur with combinations such as non-steroidal anti-inflammatory drugs (NSAIDs), phenytoin (Dilantin), carbamazepine (Tegretol), and valproic acid (Depakene) or when the albumin level is low.",0
The patient had a favourable outcome.,0
The report emphasizes a thorough and detailed assessment of deaths which occur during treatment with neuroleptic drugs.,0
Reports of this phenomenon in animals are reviewed.,0
Squamous cell carcinoma.,0
"This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.",1
Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.,1
This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.,1
We present a brief review of the mechanism of action of TNF-alpha antagonists and their ability to predispose to various infections including viral pneumonia by interfering with the immune response.,0
The use of pamidronate for hypercalcemia secondary to acute vitamin D intoxication.,1
"RESULTS: Ethambutol, and to a lesser extent isoniazid, are both implicated in the development of visually related side effects.",1
"Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.",1
"A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).",1
Genotyping of CYP2B6 and therapeutic drug monitoring in an HIV-infected patient with high efavirenz plasma concentrations and severe CNS side-effects.,0
"8 months later she was scheduled for salvage chemotherapy with gemcitabine (1,000 mg/m(2) days 1 and 8) and docetaxel (75 mg/m(2) day 8) due to locally progressive disease.",0
METHODS: A 36-year-old man sustained a flap dehiscence following traumatic right eye gouging by a seagull claw.,0
Cyclosporine-induced pain syndrome in a child undergoing hematopoietic stem cell transplant.,1
"This case supports the view that in gold-induced pneumonitis a prolonged treatment with corticosteroids may be necessary, as lung function continued to improve.",1
Poison oak and related hypersensitivity dermatitides are age-old problems that have historically been treated with herbal medicines before the availability of corticosteroids.,0
Erosion of psoriatic plaques after chronic methotrexate administration.,1
Insulin-induced cardiac failure.,1
IFNalpha-induced recurrence of Graves' disease ten years after thyroidectomy in chronic viral hepatitis C.,1
"The profession must assume responsibility for studies to determine the safety of the methods of application of the hydrogen peroxide, salt and baking soda mixtures and disseminate this information for the public interest.",0
"However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.",1
A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea.,1
"Therefore, wide spectrum antibiotics were continued.",0
RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.,1
"Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as ""red man syndrome"" and anaphylaxis.",1
Selective catheterization of the tumor vessels is the established standard in TACE.,0
Rhabdomyolysis has been recognized as a complication of tocolytic therapy with ritodrine hydrochloride.,1
The criterion for TD was a score of > or = 3 on one item or 2 on two or more items of the ESRS.,0
"The other patient was treated with amphotericin B and discharged, with a central venous catheter, after recovery from neutropenia.",0
A major limitation in the use of amphotericin B is its potential to cause nephrotoxicity.,1
Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.,1
Further doses were required as the respiratory depression recurred.,0
"We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).",1
Platelet recovery and clinical improvement coincided with administration of rituximab.,0
"We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.",1
None of the transfusion-dependent patients benefited.,0
Aggressive management of doxorubicin-induced cardiomyopathy associated with 'low' doses of doxorubicin.,1
"CONCLUSIONS: These results suggest that clozapine may cause TD; however, the prevalence is low and the severity is relatively mild, with no or mild self-reported discomfort.",1
"Statins are associated with a small, dose-related risk of myopathy, myositis, and rhabdomyolysis.",0
Life-threatening hyperkalemia induced by arginine.,1
Heparin sodium is routinely used in the prophylaxis against deep venous thrombosis in medical and surgical patients.,0
"Once again, severe dyspnea, cough, and wheezing developed.",0
"Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.",1
A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.,1
"The urinary concentrations of the main tubular enzymes (gamma-glutamyltranspeptidase, N-acetyl-glucosaminidase, alpha-glucosidase) proved very high and successively decreased slowly.",0
Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.,1
Rhabdomyolysis following clarithromycin monotherapy.,1
This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.,1
During the two weeks following the commencement of this treatment she occasionally complained of shortness of breath.,0
Data on the use of 25-OH D show no greater benefit than for vitamin D.,0
"We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine.",1
We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.,1
Sequential appearance of immunoblastic lymphoma and acute nonlymphocytic leukemia in a patient with angioimmunoblastic lymphadenopathy.,0
"One child was briefly treated with imipramine, with similar results.",0
"Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.",1
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.,1
Fluctuating QTc interval in an asymptomatic patient treated with methadone for chronic pain.,0
There was no relation between functional improvement and increased sexuality.,0
We encountered four patients who developed Acanthamoeba keratitis while wearing contact lenses that had been stored in homemade saline.,0
"On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.",1
Recent studies have found clozapine a highly effective and ECT a possibly useful intervention.,0
Dobutamine 5 micrograms.kg-1.min-1 and sodium nitroprusside 1 microgram.kg-1.min-1 were used to increase cardiac output.,0
Niacin maculopathy.,1
"Chronic ischemic changes in the white matter may have been an additional factor in the causation and, most likely, in the duration of his status.",0
No side effects or drug interactions were observed.,0
The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial.,1
The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.,1
"OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.",1
OBJECTIVE: To report a case of angioedema associated with losartan administration.,1
"Emphasis is placed on the significance of the possible relationship and similarity between NIS and catatonic stupor, and on the theoretical possibilities which this offers.",0
Brain imaging was normal in all.,0
Psoriasis-like skin reaction in a patient with rheumatoid arthritis after sulphasalazine therapy.,1
A diagnosis of trastuzumab-induced pneumonitis was made.,1
There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.,1
"The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.",1
We report the case of a 27-year-old woman with hyperthyroidism during pregnancy.,0
Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.,1
Corynebacterium Group JK organisms are common contaminants of the normal skin flora.,0
Bisphosphonate-related osteonecrosis of the skull base.,1
"However, a cross-correlation analysis indicated that TPO responses preceded platelet responses by approximately one day in all patients.",0
CONCLUSION: This report shows thatimmune-mediateddiabetes mellitus can occur as a late complication of alfa-interferon therapy.,0
Easily reversible hypoxemia and hypotension induced by nimodipine.,1
RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.,1
Body temperature was reduced to 26 degrees C and rhabdomyolysis due to hypothermia was observed.,0
First case of ivermectin-induced severe hepatitis.,1
"Dysphagia, though uncommon, can be quite debilitating and can mimic a paraneoplastic syndrome.",0
"To our knowledge, this paper is the first to describe long-term experiences with patient reporting as part of a spontaneous reporting system.",0
"Neurological examination revealed atrophy of small hand muscles, especially in the left dorsal interossei.",0
Inhibition of the hepatic metabolism of warfarin by 5-FU and levamisole is the postulated mechanism of this drug interaction.,0
His treatment was initiated with tacrolimus (dose of 0.15 mg/kg/day) in two divided doses along with prednisolone 60 mg/m(2)/daily.,0
Uncertainty in medical decision making techniques occurs in the specification of both decision tree probabilities and utilities.,0
"Two weeks later, anemia, thrombocytopenia and progressive increase in BUN, creatinine and LDH were observed.",0
"Gingival hemorrhage, myelodysplastic syndromes, and acute myeloid leukemia.",0
"This process was not reversed by lamivudine therapy, hemodialysis, and the use of a Molecular Adsorbent Recirculating System.",0
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.,1
"Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.",1
Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.,1
"However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.",1
"An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.",1
Gigantomastia induced by bucillamine.,1
PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.,1
Patients were followed with sequential ocular examinations for a maximum of 36 weeks.,0
"Even if the single and total dosage of antiestrogens given to the patient is sufficient to cause tamoxifen retinopathy, this diagnosis can be excluded because, in tamoxifen retinopathy unlike in the case presented here, the deposits are not distributed in all retinal layers.",0
One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.,1
An acute psychotic illness in a young woman was initially thought to be secondary to prolonged and pathological grief.,0
Portal vein thrombosis was diagnosed in 2 patients.,0
SETTING: Tertiary pediatric cardiac center.,0
Toxicity was mainly hematological and of acceptable degree.,0
Fungal infection of implantable cardioverter-defibrillators: case series of five patients managed over 22 years.,0
"The considerable exposure to chemicals, time course and unusual pattern of organ involvement suggested a diagnosis of occupational scleroderma.",0
OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.,1
"Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.",1
"Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.",1
Serotyping revealed that the two episodes of bacteraemia were caused by different strains.,0
"Patients were treated at a healthcare facility in 160 cases, with 79 patients admitted.",0
"Therefore, we concluded that this patient's pulmonary disease was caused by calcium stearate, an additive for an antihistaminic drug.",1
We report a further case with pathological and endocrine details together with a review of the seven cases previously reported and possible mechanisms.,0
OBJECTIVE: To report two cases of fixed drug eruption induced by methylphenidate.,1
"To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported.",1
Widespread dermatophyte infections that mimic collagen vascular disease.,0
"He also achieved a complete response but only after rituximab was added to IVIG, gancyclovir, solumedrol and IFN.",0
Ototoxicity as a result of cis-platinum administration is well documented.,1
Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.,1
Implications for professionals who care for lactating women are discussed.,0
The Jarisch-Herxheimer reaction is a response to the treatment of syphilis.,0
Mesalamine-induced hypersensitivity pneumonitis.,1
It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.,1
"Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.",1
"DISCUSSION: Renal elimination is not a significant pathway of elimination for anastrozole, clearance of anastrozole is unchanged even in severe renal impairment.",0
"A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).",1
The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.,1
"We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.",1
"Although the exact mechanism is unknown, the time course and constellation of symptoms are consistent with a possible inflammatory pathophysiologic condition.",0
Clinicians should be alert to these potential problems in the geriatric population.,0
Cholesterol embolization treated with corticosteroids--two case reports.,0
We describe two cases of acute pancreatitis that occurred after long term mesalamine therapy for ulcerative colitis.,1
These reports suggest the possibility that the risk of developing hyperglycemia and diabetic coma with this combination may be greater than when taking diuretics alone.,0
Abnormalities resolve with drug withdrawal.,0
"The higher the number of Japanese who go abroad becomes (the total number in 1994 was 13,578,934: Records of Statistical Division of the Ministry of Justice), the greater is the risk of their contracting malaria.",0
The patients' median age was 21.5 years (range 16 to 53 years) with a median SAPS II of 14 (range 12 to 84) and an APACHE II of 8 (range 6 to 36).,0
INTRODUCTION: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative.,1
"A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.",1
"After the withdrawal of TMP-SMX and the administration of high-dose steroid, these systemic symptoms gradually resolved.",0
"She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.",1
"As nephrotic-range proteinuria, hypoalbuminemia, and general edema were worsening even 2 weeks after cessation of the drug, oral corticosteroid therapy (prednisolone 40 mg/day) was started.",0
"Dermatomyositis, complicated with pneumomediastinum, successfully treated with cyclosporine A: a case report and review of literature.",0
We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.,1
METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.,1
Asthma and urticaria during disodium cromoglycate treatment.,1
Acute myelomonoblastic leukemia in a patient with multiple myeloma.,0
It is hoped that this case report creates awareness that ofloxacin-induced toxic epidermal necrolysis is possible.,1
"BACKGROUND: Tumor lysis syndrome (TLS) is rare in the treatment of solid tumors, but it may occur in myelolymphoproliferative diseases.",0
"Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.",1
Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.,1
The patients had experienced loss of employment and the carers described a reduction in the patients' social interactions.,0
"In the first 2 cases, injections were perilesional and in the other 2, intralesional.",0
The mechanisms responsible for these conditions currently remain unclear.,0
"Both infants initially responded well to medical therapy for narcotic withdrawal, but at 7-14 days of age, withdrawal symptoms intensified, requiring an increase in the dosages of Paregoric (UDL Laboratories, Rockford, IL) and opium tincture in both infants and the addition of phenobarbital therapy in one infant.",0
"We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).",1
"IV propranolol was used as the initial treatment for his hyperadrenergic state, resulting in a decrease in heart rate but a paroxsymal increase in blood pressure.",1
Tuberculous peritonitis in patients undergoing continuous ambulatory peritoneal dialysis: case report and review.,0
Acute isoniazid neurotoxicity in an urban hospital.,1
"RESULTS: In both cases, magnetic resonance imaging demonstrated multiple small high-intensity areas in the cerebral white matter and spinal cord, while cerebrospinal fluid examination disclosed mononuclear cell increase and protein elevation including myelin basic protein, all of which simulated the features of multiple sclerosis.",0
"Second, we report a case of neutropenia, which proved to be fatal in a schizophrenia patient receiving olanzapine and thiazide.",1
Spinal cord infarction during use of zolmitriptan: a case report.,1
Acetylsalicylic acid enhances both minor and major bleedings.,0
This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.,1
Phenobarbital treatment in a patient with resistant alcohol withdrawal syndrome.,0
"The cause of death was determined to be acute intoxication by olanzapine, and the manner of death was accidental.",1
"Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.",1
Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.,1
"PATIENTS AND METHODS: Three patients with Parkinson's disease undergoing bilateral micro-recording guided surgery of the subthalamic nucleus (STN) are described; deep brain stimulation (DBS) was used in one case, and subthalamotomy in the other two.",0
RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.,1
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
"A patient presented with palmar inflammation and throbbing joint pain in his hands, as well as erythematous, pustular, and micaceous scaling skin on his right foot, legs, elbows and hands.",0
We started the subject screening from over 400 patients with Parkinson's disease using strict selection criteria to identify the patients with nocturia who would allow accurate and efficient evaluation of the pergolide effects.,0
We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).,1
"In renal transplant patients living in endemic countries, visceral leishmaniasis should be kept in mind as a potential cause of unexplained long-standing fever and considered as an opportunistic infection.",0
"Due to the costs and risks of standard therapy, we decided to manage the patient supportively.",0
Trichiasis associated with prostaglandin analog use.,1
Five patients required short-term dialysis.,0
"Bone marrow aspirations showed hypocellular-normocellular bone marrow, 98% of plasma cells.",0
Reversible treatment-related leukoencephalopathy.,0
"Diagnostic procedures did not reveal any liver, kidney, splenic, or pancreatic abnormalities.",0
"Bronchoalveolar lavage (BAL) revealed lymphocyte alveolitis with a low CD4/CD8 ratio (0.36), consistent with an immunoallergic phenomenon, rather than the most often evoked toxic hypothesis.",0
Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.,1
"We present a case report where switching from clozapine to quetiapine maintained the improvement in clinical status, after remittance of eosinophilia.",0
Patients were scored using the dyskinesia scale and started treatment with 400 mg amantadine (po) for 4 days within the first postoperative week with no effect on dyskinesia score or its phenomenology.,0
We present a case of hypereosinophilia related to zafirlukast therapy.,1
"Child-Pugh class A liver function and a platelet count of > or = 60,000/mm(3) were among the inclusion criteria for SHARP.",0
Spontaneous improvement of tardive dystonia during mania.,0
The purpose of this article is to present the first case-series of posterior reversible encephalopathy syndrome (PRES) associated with L-asparaginase treatment.,1
"Serum liver tests showed a mean total bilirubin of 1.4 +/- .7 mg/dL (range, .5-2.5) and INR was 1.2 +/- .14 (range, 1.0-1.4).",0
She developed marked liver dysfunction.,0
"To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.",1
Gastro-oesophageal reflux associated with nifedipine.,1
Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.,1
The ECG monitoring revealed sinus pause with markedly prolonged PQ interval and QRS width.,0
The severity of this syndrome primarily in patients undergoing second HPCTs suggests that repetitive exposure to high-dose therapy may compromise endogenous peripheral regulatory mechanisms and predispose these patients to autoimmunity.,0
Unique behavioral change with cinepazide in parkinsonism.,1
"PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.",1
"The great majority of these patients were diagnosed with actinomycotic diseases during or after exploratory laparotomy, but rarely preoperatively.",0
"It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.",1
Differences were found in the categories of seriousness and outcome of the reported ADRs between patients and healthcare professionals.,0
"However, progression to overt cardiac failure has only recently been reported in one patient with pre-existing heart disease.",0
Extraskeletal tumoral calcifications (TC) may occur in patients with end-stage renal disease.,0
"These microorganisms are recognized as the cause of devastating soft tissue infections, such as cellulitis, myositis, and gas gangrene.",0
Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.,1
"On 26 April 1999, three persons were accidentally exposed by high dose (60)Co irradiation.",0
Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.,1
Examination revealed a fully conscious patient with slight dyspnoea and mild wheezing which responded to oxygen 30% and nebulised bronchodilators.,0
The current article highlights the hepatotoxic potency of a widely administered therapeutic agent and illustrates the importance of clinical surveillance especially in patients with previous hepatic diseases.,0
"It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.",1
Vigabatrin (VGB) is an important treatment option for infantile spasms.,0
"Following three courses of chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF), the patient had a dramatic clinical reduction of tumor, reduction of serum CA 15-3 from 161 to 64 U/ml, and underwent a modified radical mastectomy and axillary dissection.",0
"In the two new cases, the causality assessment was judged as ""possible"" according to the RUCAM score.",0
"Because psoralens sensitize skin to ultraviolet A light, phototoxic reactions are the most frequent adverse effect of this treatment.",1
A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.,1
"Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.",1
We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).,1
"DESIGN: We reviewed the medical records of four patients, who were seen by us between July 2000 and February 2004 for sudden onset of a central neurological syndrome within days of intrathecal MTX.",1
This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.,1
"Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.",1
"However, clozapine must be used cautiously due to its side effect profile.",0
Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.,1
Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: a preliminary study.,0
We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.,1
Doxycycline-induced hypoglycemia in a nondiabetic young man.,1
Photo-onycholysis caused by olanzapine and aripiprazole.,1
The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.,1
Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.,1
"We describe the clinical course, renal function, and blood viral measurement in 6 renal transplant recipients with BKVN who were treated with low doses of cidofovir.",0
"In this case, the dose was slowly reduced after delivery, and the maternal lamotrigine serum concentration more than doubled in the week before the neonatal apneic episodes.",0
Single and multiple verrucous plantaris lesions are well known for their resistance to conservative methods of treatment.,0
Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.,1
"A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.",1
"Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.",1
PURPOSE: To report a case of herpes zoster ophthalmicus reactivation following laser in situ keratomileusis (LASIK) for myopia.,0
"Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature.",1
The pathogenetic mechanism of these symptoms might possibly be explained as potentiation of the action of the neuroleptica by oral antidiabetics.,0
We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.,1
The regimen was based on conditioning experiments with animals who had lupuslike autoimmune disease.,0
"However, a new episode of neutropenia, with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3, occurred 11 days after teicoplanin initiation.",1
The observed serum ceruloplasmin response after parenteral copper administration is suggestive of an impairment in the incorporation of copper into this metalloprotein.,0
"In an elderly patient with unresolving acute bronchospasm, herpesvirus infection of the lower respiratory tract should be considered in the differential diagnosis.",0
Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.,1
Treatment with naloxone resulted in rapid reversal of signs without sequelae.,0
Intravenous azithromycin-induced ototoxicity.,1
We report the use of pharmacokinetic analysis of daptomycin in a 13-year-old boy with vancomycin-resistant Enterococcus faecium endocarditis.,0
"Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.",1
We suspect that nefazodone inhibits metabolism of tacrolimus.,1
CONCLUSION: Hypersensitivity reaction should be considered in patients who develop recurrent eosinophilia and deterioration of pulmonary function following the use of tobramycin by inhalation or by intravenous administration.,1
"In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.",1
PARTICIPANTS: Four patients with periocular hemangioma.,0
This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.,1
The tendency to develop AV block in a patient who is euthyroid was reduced by bypass tract conduction.,0
This combination was shown to be synergistic.,0
"Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.",1
"These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.",1
"Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.",1
Encephalopathy and seizures induced by intravesical alum irrigations.,1
CONCLUSIONS: Intravenous therapy with the anti-CD20 antibody rituximab is a nontoxic and effective treatment for patients with primary cutaneous B-cell lymphoma.,0
"Diethyl carbamazine citrate, an inhibitor of release of SRS-A, seemed to shorten the duration of the LAR, although it has no effect on the immediate response and/or on the severity of the LAR.",0
An abdominal radiograph revealed gross fecal loading.,0
Three cases of acute renal toxicity in patients receiving long-term therapy with mitomycin C and 5-fluorouracil are reported.,1
Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.,1
"Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache.",1
RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.,1
An increase of intoxications in persons using alkaloid-containing ornamental plants (mainly angel's trumpet) for their hallucinogenic effects and easy and cheap availability is registered.,0
Interaction between methotrexate and ciprofloxacin.,0
"A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.",1
Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.,1
Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.,1
"In this case, unlike those previously reported, hyponatremia recurred 5 months after switching from citalopram to mirtazapine, which is believed to be a safe antidepressant.",1
"With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.",1
"Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.",1
Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.,1
"All three patients had previously experienced good responses to sumatriptan or zolmitriptan, but were limited in frequency of use by the authors.",0
"In patient 1 with massive pulmonary thromboembolism, transesophageal ultrasound revealed large right atrial thrombus entrapped in a patent foramen ovale.",0
Multicyclic dose-intensive chemotherapy supported by autologous blood progenitor cell transplantation for relapsed small cell lung cancer.,0
No other identifiable factor contributed to the unresponsiveness.,0
The case study reports were linked to and discussed in relation to possible explanatory models for increased olfactory sensitivity.,0
"A case of sideroblastic anemia is presented in a patient with a left ventricular assist device drive-line infection who was receiving linezolid, an antibiotic used for serious infections with gram-positive organisms.",1
"Through a literature search, we were able to identify 4 additional cases of therapy-related AML in AIDS patients following chemotherapy for lymphomas.",0
We suggest discontinuing gemcitabine if radiation recall is observed.,1
"Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.",1
We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ).,1
Vasomotor reactions after gold sodium thiomalate are well recognized.,1
Effects of the two forms of pulse appear similar.,0
Noncardiogenic pulmonary edema after transfusion therapy is an infrequent but hazardous complication.,0
Microscopic examination showed nests of mature adipocytes expanding toward the dermal reticular layer.,0
"Idiosyncratic pulmonary reactions to nitrofurantoin are not unusual, often presenting as eosinophilic pneumonia.",1
Hypersensitivity reaction is an unexpected drug adverse effect which sometimes can lead to fatal condition.,0
Lichenoid drug eruption to salsalate.,1
A frequent problem is relapse of disease when corticosteroid dosage is tapered off.,0
"We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus.",1
We report five cases of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) that were probably associated with olanzapine.,1
Vincristine levels were also assayed and showed a dramatic decline in postexchange levels in the 2 patients who survived and an almost unchanged value in the patient who succumbed.,0
"Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.",1
A reticular pattern on high resolution CT (HRCT) invariably represents significant lung pathology and is the dominant feature of irreversible fibrosis.,0
We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.,1
A 27-year-old Caucasian woman with end-stage Crohn's disease was hospitalized with an upper extremity thrombosis.,0
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.,1
Levofloxacin-induced delirium with psychotic features.,1
MAIN RESULTS: Followup echocardiogram on day 10 showed complete resolution of the thrombus.,0
"In this healthy population, the relative risk of developing endometrial carcinoma in the tamoxifen arm was 2.54, although when stratified by age, in women over 50, the risk grew to 4.01.",1
Histopathologic examination revealed adenomyosis with cyst formation and an unusual thick capsule.,0
We describe a patient who developed HUS after treatment with mitomycin C (total dose 144 mg/m2) due to a carcinoma of the ascending colon.,1
"Recently, RA has been added to the post-BMT therapy in children with stage IV neuroblastoma.",0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
A detailed description of the cardiac event is provided for one patient who was on a cardiac monitor during the adverse reaction.,0
"CONCLUSION: We review the literature of reported cases of primary osteogenic sarcomas of the skull to discuss the common clinical presentation, evaluation methods, and recommended treatment plans.",0
"Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.",1
"Biperiden was transiently effective in the acute akathisia, while the more persistent akathisia was alleviated by mianserin.",0
Hypo-oestrogenic and anabolic/androgenic side-effects of danazol are well known by the gynaecologist and some of them are present in > 50% of patients being treated for endometriosis.,1
A 22-year-old man with a synovial cell sarcoma attained an excellent response to therapy with adriamycin (NSC-123127) and dimethyltriazeno imidazole carboxamide (NSC-45388).,0
"The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.",1
"Here, we describe two patients who developed severe proteinuria after renal transplantation, despite effective blood pressure control with an ACE inhibitor.",0
The use of clonidine alone and in combination to treat a variety of problems has increased in child and adolescent patients.,0
"Amiodarone treatment did not abolish the thyroid radioactive iodine uptake (RAIU), allowing for subsequent treatment with radioactive iodine.",0
5-Fluorouracil cardiotoxicity complicating treatment of stage IIB cervical cancer--case report.,1
Stool specimen was streaked with blood.,0
"Both agents are excreted by the kidneys, raising the possibility that acyclovir at high serum concentrations may interfere with the renal excretion of lithium.",0
New onset of CD may be considered as an immune-mediated injury induced by etanercept.,1
"OBJECTIVE: We describe the prolonged clinical benefit of murine chimeric antitumor necrosis factor (TNF)-alpha monoclonal antibody, infliximab, on pediatric patients with Crohn's disease and ileal pouch anal anastomosis (IPAA).",0
"We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.",1
"On followup, the patient reported disappearance of symptoms.",0
"Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.",1
These patients may develop systemic sepsis through bacterial or fungal translocation across the intestinal wall.,0
"k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.",1
"She subsequently developed a classic varicella rash, sever back pain, rapidly progressive hepatic failure, pneumonitis, and encephalopathy.",0
PURPOSE: To investigate the concentration-side effect relationship in a patient with severe acyclovir-induced neurotoxicity and to summarize the information available in the literature about central nervous system side effects due to acyclovir.,1
"Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.",1
Precursor prothrombin status in two mother-infant pairs following gestational anticonvulsant therapy.,0
The man died from complications related to toxic epidermal necrolysis.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
This case illustrates an association between CMV and TMA in a transplant patient with resolution of the latter after treatment of the CMV.,0
A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl).,1
Ezetimibe-induced acute pancreatitis.,1
"Care must be taken in the management of lumbosacral intradural tumors because tumors resembling neurilemmoma may in fact represent meningioma, some subtypes of which possess a high rate of recurrence.",0
This is in contrast to similar symptoms reported by only 8 percent of a control population.,0
"Electrophysiologic data obtained before and during thyroxine replacement therapy showed that hypothyroidism lengthens the effective refractory period of the atria, AV node, bypass tract and His-Purkinje system (that in the ventricle not being measured); this lengthening resembles the effects of long-term administration of amiodarone.",0
"Cure followed therapy with antibiotic administration for 3 days combined with oral thiabendazole, suggesting parasitic infection as the most likely cause of meningitis.",0
Hepatic reactions to cyclofenil.,1
Diuresis returned within 12 h.,0
"The diagnosis was based on the rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy finding, following the administration of ampicillin.",1
Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.,1
"However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.",1
The former diagnosis was supported by a subsequent in-vitro HEPTEM.,0
The association of central diabetes insipidus (CDI) with lithium use is rare.,1
"METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.",1
"Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.",1
This is our first well-documented observation of persistent cutaneous anesthesia caused by a spider bite.,0
"Hyperpigmentation is one of the cutaneous side effects of chemotherapautic agents, but it is usually accepted as a cosmetic problem.",0
Treatment has mainly been empirical.,0
"The combined use of central nervous system depressant drugs, together with her problematic sleep apnea, and snoring (both contraindications for GHB use) were determined to have caused this subject's death.",0
Limited data suggest that TNF-alpha inhibitors may facilitate uncontrolled hepatitis B viral replication.,0
"To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.",1
"The reaction is thought to be due to the effects of treponema breakdown products, and it should not be confused with an allergic reaction to the antibiotic employed.",0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"It can be caused by a variety of factors, including repeated steroid injections, chronic tenosynovitis, and decreased blood supply to the tendon.",0
"Alopecia, nausea, and vomiting were attributed to the cyclophosphamide component of the therapy.",1
This case report describes a 13-year-old male with diagnosis of autistic disorder and fetishistic behavior.,0
We obtained the following results.,0
We report here the case of a patient with peritoneal metastases of GIST involving the pelvis treated by imatinib.,0
"Clinicians who manage cachectic patients, particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine, should be aware of the risk of severe hypoglycaemia.",1
"Terbutaline, therefore, may represent a useful alternative for chronotropic support in the setting of heart transplantation.",0
The patient was treated with radiofrequency cautery and is now asymptomatic.,0
This is the first report of a possible association between an acute cardiovascular event and venlafaxine.,1
"An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.",1
No abnormalities were identified on review of collection and processing records.,0
"A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.",1
Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature.,1
"Following IVIG infusion, lupus encephalitis in the first patient quickly resolved and the impressive improvement of the clinical status was associated with a transient increase in C1q-binding activity.",0
Possible mechanisms of action are discussed.,0
"During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.",1
We report a case with chronic hepatitis C (CHC) who developed sarcoidosis after the treatment by interferon alpha and ribavirin.,1
Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.,1
Histopathology examination of the excised flap demonstrated numerous Acanthamoeba cysts in tissue sections.,0
"Thereafter, sixteen cycles of immunoglobulin treatment (400 mg/kg) along with corticosteroids were instituted and led to an improvement in subjective symptoms with decreases in level of CPK and LDH.",0
"Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.",1
"Paradoxical exacerbation of the signs and symptoms of tuberculosis may occur not only after antituberculosis therapy, but also soon after the initiation of a potent combination of antiretroviral drugs in human immunodeficiency virus (HIV) serpositive patients with tuberculosis.",0
"Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.",1
Such a low incidence suggests a hypersensitivity type of reaction.,0
Both the long-term affects of residual catheter within the central venous system and the need to remove the foreign body have yet to be addressed.,0
Recurrent spontaneous intracerebral hemorrhage in a congenitally afibrinogenemic patient: diagnostic pitfalls and therapeutic options.,0
"With the increasing use of tacrolimus in steroid-resistant nephrotic syndrome, the treating physicians need to be aware of this rare, but potentially life-threatening side effect.",0
Average length of stay postCDT was 7 days with no perioperative complications.,0
"Following, we performed a double-blind oral challenge test with drugs who results was negative.",0
There are now reports of liver failure following treatment of childhood cancers with AMD.,1
Interstitial pneumopathy and low-dosage amiodarone.,1
"Blood glucose levels, which were normal before treatment, dropped to 2.3 mmol/l within a few hours and were corrected by i.v. glucose infusion.",0
"While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.",1
Sequential CT studies of 24 children with infantile spasms on ACTH therapy.,0
Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis.,1
We report a case of ST elevation in right precordial leads compatible with type 1 Brugada syndrome following administration of propafenone in a patient with Wolff-Parkinson-White syndrome who was receiving lithium at concentrations within therapeutic levels.,1
"In case #2, the concentrations of quetiapine found were 16 mg/L in blood (42 micromol/L), 120 mg/kg (310 micromol/kg) in liver, and 1.8 mg/L (4.6 micromol/L) in vitreous fluid.",0
"It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called ""3-week sulphasalazine syndrome"", a rare, but often fatal, immunoallergic reaction to sulphasalazine.",1
Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.,1
"CASE: We present here the case of a patient with protein S deficiency, who has used COCs together with anticoagulatory therapy (Phenprocoumon) after suffering from deep venous thromboses for 4 years.",0
MCD was steroid-resistant type.,0
"Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drug.",1
"ENT surgeons, general physicians, and infertility experts should consider this in the differential diagnosis of neck swellings, particularly after OHSS and IVF treatment, and in this case report, we emphasis the need for an urgent ultrasound of the neck in such patients.",0
Theophylline intoxication mimicking diabetic ketoacidosis in a child.,1
"Prospective, controlled trials are warranted to further define the optimal dose, toxicity and potential role of cidofovir in renal transplant recipients with BK virus nephropathy.",0
Normal plasma levels of these drugs were found 2 to 3 days after the last cisplatin dose.,0
"We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.",1
"Cases include typical and unusual presentations of the syndrome, and commonly encountered problems and pitfalls of therapy.",0
"Improvement and deterioration in systolic function on echocardiogram and serum B-natriuretic peptide levels were seen while receiving ATRA 1 week on and 1 week off, respectively, during the maintenance phase of therapy.",0
"If antiarrhythmics are administered that are contraindicated in patients with WPW syndrome, then there is potential for deleterious effects.",0
A bone marrow aspiration test on day 16 showed a markedly increased number of activated macrophages showing massive hemophagocytosis.,0
A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.,1
Observation of renal biopsy specimens by light microscopy revealed minor glomerular abnormalities.,0
"The VPA concentration following this dose escalation was 392 micromol/L, and the patient improved clinically.",0
Malignant neoplasm after immunosuppressive therapy is a well-known entity.,0
"She initially presented with pelvic and lower back pain, and imaging showed a pelvic deep venous thrombosis (DVT) and an interrupted IVC.",0
"According to the literature, chlorambucil central nervous toxicity is found almost exclusively in childhood nephrotic syndrome.",1
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
"The tacalcitol treatment was terminated, seven days later, the serum calcium level had returned to the reference range without any specific treatment.",0
Patients experienced a mean reduction of 92% (a mean drop in frequency of 21.7 to 1.7 episodes per week).,0
Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.,1
All 4 patients developed steroid-induced glaucoma and failed traditional immunosuppressant therapy.,0
"Therefore, we recommend that physicians evaluate serum theophylline levels closely when prescribing the 2 drugs in combination.",0
The sub-conjunctival haematoma in a patient receiving warfarin can pose a significant management challenge.,1
"Both these cases of PTLD achieved a complete response following treatment with IVIG, gancyclovir, solumedrol and interferon (IFN).",0
Leflunomide-associated infections in rheumatoid arthritis.,1
Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.,1
Stopping further solvent exposure failed to improve his condition.,0
"Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.",1
We present a case of an anaphylactoid reaction in a 62-y-o female following a first-time envenomation by a rattlesnake.,0
"In 3 patients, leukoencephalopathy was diagnosed by T2-weighted magnetic resonance imaging.",0
"Surprisingly, insulin therapy had to be suspended because of hypoglycemic fits and treatment with metformin was started.",0
"Treatment for 1 year or longer decreased tumor secretion of gastrin and diminished basal acid secretion, an effect that persisted for 48 hours after withdrawal of SMS.",0
Didanosine also has a potential for inducing seizures.,1
"We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.",1
Gold-induced aplastic anemia.,1
Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.,1
"The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.",1
"We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.",1
This report presents a patient with membranoproliferative glomerulonephritis (MPGN) who developed KS following treatment with long-term medium dose glucocorticoid and short-term additional immunosuppressives.,0
We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.,1
Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.,1
A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).,1
A brief discussion of this case and the use of digoxin-specific antibodies is presented.,0
Cardiac hypersensitivity and myopericarditis have been reported during long-term treatment with mesalazine.,1
We report a case of baclofen withdrawal syndrome resulting from oral baclofen underdosing.,1
Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.,1
The exact mechanism of IVIG-associated acute renal failure remains unclear.,1
We suggest that the specific immunosuppression used in renal transplant patients might facilitate the development of a dormant infection and in these patients the misleading presentation may delay the diagnosis.,0
"Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.",1
"Spacers have evolved from simple monoblock designs made of acrylic cement alone to articulated, modular, complex and expensive designs with different grades of constriction.",0
"On April 2, escitalopram was started.",0
RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.,1
PURPOSE: To present a case of recurrent postoperative endophthalmitis with a scleral-tunnel abscess and adjacent microbial keratitis.,0
A 32-year-old white woman with major depression was treated with venlafaxine for 3 years.,0
We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.,1
"None of the patients had a previous history of glaucoma, ocular hypertension or IOP asymmetry and the IOP was as high as 30, 34, 46, and 50 mmHg in the four patients.",0
We present a patient with human immunodeficiency virus infection under treatment with foscarnet for CMV retinitis who complained of thirst and polyuria.,1
"We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.",1
The patient who survived had been taking the lowest dose of azathioprine and was given the recommended dose of acyclovir.,0
Fibrosis of corpus cavernosum after intracavernous injection of phentolamine/papaverine.,1
The combination of selective serotonin reuptake inhibitors and tricyclic antidepressants may be useful in treating patients who experience intolerable side effects or who are resistant to therapy with a single antidepressant.,0
"In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.",1
"CONCLUSIONS: We are unable to explain the exact mechanism of the observed RPE changes; however, they did not lead to loss of visual acuity.",0
"A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.",1
"Positive immunohistochemistry staining of a biopsy specimen for cytomegalovirus suggested a viral etiology; however, lesions persisted despite antiviral therapy, and immunohistochemistry was negative on follow-up biopsy.",0
Three cases of self-inflicted gingival injuries resulting from the improper use of the Keyes technique are presented.,0
OBJECTIVE: Clozapine causes few extrapyramidal symptoms and is recommended as a treatment drug for severe tardive dyskinesia (TD).,1
"Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.",1
"Increasing evidence suggests that neurohumoral manifestations of heart failure may lead to insulin resistance, predisposing patients with heart failure to the development of glucose intolerance or worsening of existing diabetes.",0
"Although PTLD is uncommon in the general community, the incidence has continued to increase as more patients undergo transplants and clinical presentations of PTLD should be familiar to the otolaryngologist.",0
"We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.",1
"Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.",1
There was a good correlation between the total dose of ACTH and the percentage decrease of brain parenchyma.,0
These observations suggest that E. avium bacteremia most often originated from a gastrointestinal tract source.,0
Fatal toxic epidermal necrolysis related to lamotrigine administration.,1
"A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",1
Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.,1
5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.,1
"We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.",1
An 82-year-old woman with type 2 diabetes had been treated with recombinant human insulin for 16 years.,0
This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.,1
"Best known are urticaria, erythema, and pruritus; sometimes pseudoallergic anaphylactoid reactions, and blisters are reported.",0
"A twelve year-old-girl with idiopathic partial epilepsy with secondary generalization, developed acute psychosis 10 days after the administration of levetiracetam.",1
OBSERVATIONS: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod.,1
"This appears to cause immediate regression of the neovascular frond and allows time for the laser, which is applied subsequently to have its effect.",0
The patient was started on increasing doses of levothyroxine for subclinical hypothyroidism.,0
L-Thyroxine-induced leukopenia in a patient with Hashimoto's disease: involvement of suppressor-cytotoxic T cells.,1
"The relevant literature is reviewed; a case history is presented; and implications for nursing care (e.g., early detection) are discussed.",0
The patient could be disconnected from the ventilator and within <24 h was extubated.,0
"Reactivation of human herpesvirus-6 (HHV-6) is frequently observed, although the cause of DIHS is still unknown.",0
"Laboratory tests showed creatine kinase 144600 IU/L (reference range 24-195), myoglobin >3000 ng/mL (28-72), lactate dehydrogenase 7157 IU/L (230-460), aspartate aminotransferase 1115 IU/L (10-35), and alanine aminotransferase 205 IU/L (10-35).",0
Ifosfamide-associated neurotoxicity was noted within hours of drug administration and improved rapidly following hemodialysis.,1
He was treated by TACE.,0
Intravitreal corticossteroids have been used for therapeutic purposes in optimum doses and adverse reports have not been described.,0
"Although the cumulative probability of acute non-lymphocytic leukemia among surviving patients at five years using life-table statistics was 7.6%, the survival curve for the 553 patients with ovarian carcinoma was only slightly affected by death from leukemia.",0
Oculogyric crisis is a neurologic reaction characterized by bilateral dystonic elevation of visual gaze as well as hyperextension of the neck.,0
"INTRODUCTION: Although the copperhead (Akistrodon contortrix) is responsible for most Crotaline envenomations in the Carolinas, manifestations and treatment are poorly characterized.",0
"Although there have been numerous reports of effusions, none have provided complete pleural fluid analysis; therefore, we report 2 patients with dasatinib-induced pleural effusion with complete pleural fluid analysis.",1
"Although the source and timing of HBV exposure remain unclear, the potential for severe hepatitis B infection following bone marrow transplant warrants caution.",0
"The second was an 82-year-old man receiving ticlopidine for 2 years when, during a febrile episode, he was found neutropenic with marrow aplasia.",1
The combination of raltitrexed (Tomudex) and mitomycin-C in the treatment of advanced colorectal cancer--a phase II study.,0
Histologic examination also revealed multiple shallow ulcers accompanied by cytomegalovirus infection.,0
This is the first described case of acute gouty arthritis after RFA for a HCC lesion in a patient with underlying chronic renal insufficiency.,0
Methylglyoxal bis-dihydrochloride is a drug that has been available for use in cancer chemotherapy since 1955.,0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"Unexpectedly, liver function returned to normal on stopping the drug.",0
"We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.",1
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
"With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.",1
It may also be prudent to screen for electrolyte abnormalities in patients taking this agent to prevent serious iatrogenic complications.,0
L-T4 stimulated lymphocyte transformation in this patient.,0
Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.,1
"Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.",1
Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.,1
Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.,1
Off-label use should be discouraged.,0
Lack of recognition that the lungs too may be a site of spontaneous hemorrhage during thrombolytic therapy may lead to a considerable diagnostic and therapeutic delay.,0
CONCLUSION: A possible pharmacokinetic interaction between Dantrolene and Oxybutynin should be borne in mind when considering Carbamazepine medication for a patient with a spinal cord lesion.,0
Thirteen parkinsonian patients drawn from two large parkinsonism clinics experienced hypersexuality as a consequence of anti-parkinsonian therapy.,0
This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.,1
A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.,1
Allergic and irritant contact dermatitis to calcipotriol.,1
We describe a patient with idiopathic RLS who developed augmentation after 8 months of levodopa treatment.,1
Neutropenic enterocolitis should be considered in patients with abdominal symptoms especially during the granulocyte nadir following chemotherapy.,0
Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine.,1
"On rechallenging the patient with the drug following the implantation of a permanent pacemaker, intermittent complete heart block developed.",0
"Several cases of lithium-induced Creutzfeldt-Jakob syndrome have been reported to date; all of them were elderly patients and a half had ""therapeutic"" lithium serum levels.",1
"Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.",1
We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.,1
Topical capsaicin cream has been a beneficial adjuvant medication in the treatment of some painful conditions.,0
"However, acute cardiomyopathy and pericarditis secondary to methylphenidate use has been rarely reported.",1
Early phase-II semi double-blind study of the new alkaline propanolamine derivative enciprazine (short communication).,0
Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.,1
Pulmonary toxicity associated with erlotinib.,1
Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.,1
Pediatric clonidine intoxications.,0
The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.,1
One major concern with the use of intraperitoneal therapy is the risk of inducing peritoneal sclerosis and extensive adhesion formation.,0
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
"Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases.",0
"Sputum cultures were positive for methicillin-resistant Staphylococcus aureus, and intravenous vancomycin 1 g every 8 hours was added to the treatment regimen on hospital day 7.",0
"We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.",1
"Perhaps more importantly, this study suggests that DPOAEs may have the potential to predict the earliest stages of progressive hearing loss before such changes are seen in audiometric thresholds.",0
"Unlike other macrolide antibiotics, it is not hepatically metabolized and did not produce an interaction with warfarin in a single-dose study.",0
Follicular cell carcinoma of the thyroid in a child after bone marrow transplantation for acute lymphoblastic leukemia.,0
A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement.,1
20% of the reported cases of t(8;16)(p11;p13) AML are therapy-related and this case further supports the possible role of the ionizing radiation in the development of this disorder.,0
"As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.",1
Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris.,1
Persisent ocular hypertension following intravitreal ranibizumab.,1
We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.,1
"Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.",1
Systemic corticosteroids in the phenytoin hypersensitivity syndrome.,1
"An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.",1
There are no human data regarding the safety of very high dosages of lacosamide.,0
"Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.",1
"After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.",1
We report the first case of herpes esophagitis in a renal transplant patient treated with Cyclosporine A while on chronic steroid therapy.,1
Patients receiving these agents are at risk of acute or subacute pulmonary damage.,0
We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.,1
The cough continued for the duration of therapy with quinapril.,1
We describe two patients who developed hypophosphatemia as a consequence of this form of therapy.,0
"We report a case of late cerebral toxoplasmosis reactivation, which was probably triggered by a brief course of corticosteroids, administered for chronic graft-versus-host disease (cGVHD).",0
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
Tardive dyskinesia in 2 patients treated with ziprasidone.,1
These cases are discussed in the context of evidence that lithium may be useful in other patients with disorders of impulse control.,0
CONCLUSION: A woman receiving enoxaparin every 12 hours developed signs and symptoms of hepatotoxicity after the second dose.,1
Of note is that the renal histology at autopsy showed a remarkable improvement of mesangial hypercellularity with concomitant reduction in the number of glomerular macrophages.,0
"On the other hand, aspirin may have promoted the enlargement of spontaneous hemorrhage from meningioma.",1
"Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.",1
"CONCLUSION: It is important to elucidate the precise nature of new onset hearing loss in patients receiving iron chelation therapy, in order to avoid unnecessary cessation of much needed medication, on the assumption of ototoxicity.",0
Minocycline as a cause of drug-induced autoimmune hepatitis.,1
Adrenal crises in children treated with high-dose inhaled corticosteroids for asthma.,0
Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.,1
The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine.,1
The lesions resolved completely approximately 30 min after removal of the hands from water.,0
Histologic examination of skin biopsy specimens from the patients' UV-B and UV-A test sites and lesional skin revealed an acute eczematous dermatitis.,0
"The former patient had complained once that his visual acuity had decreased after the termination of IFN therapy, and the latter patient complained twice during IFN therapy that his visual acuity had decreased.",1
"18 perfusions were performed on 15 patients with stage II disease, that is with tumor growth restricted to an extremity including possible regional node metastases.",0
"Possible precipitating factors were damage to the subclavian vein, congestive heart failure, paroxysmal atrial fibrillation, and immobilization.",0
Alprazolam-induced mania: two clinical cases.,1
Multifocal electroretinographic abnormalities in ethambutol-induced visual loss.,1
"We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.",1
The ACAD is defined as a diffuse process affecting the entire length of epicardial vessels.,0
Total excision of the lesions with concomitant four-combined antituberculous therapy proved successful.,0
There is no consensus on the treatment of ticlopidine-induced marrow aplasia.,1
Recombinant human alpha-interferon (IFN) at a dose of 3 million units combined with melphalan and prednisolone was administrated.,0
"Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.",1
"A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.",1
Lower extremity arterial insufficiency after long-term methysergide maleate therapy.,1
"In a single practice during the 21 years 1971-1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p < 0.001).",1
"On visual field testing, a progressive evolution to a total and absolute central scotoma in the RE (central 10 degrees ) and an annular scotoma in the LE became apparent.",0
The striking chemical abnormality was an elevation of serum glutamic oxalacetic transaminase (SGOT) [aspartate aminotransferase (AST)].,0
"We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).",1
Further work-up led to the diagnosis of anterior spinal artery syndrome.,0
Care providers who refill pump reservoirs with morphine must be knowledgeable about these devices and the life-threatening consequences associated with errors in refilling them.,0
"As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.",1
"We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.",1
We describe a 51-year-old woman with sacroiliitis following a fall.,0
"A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.",1
Its ease of administration makes it an ideal drug to treat patients in the outpatient setting while maintaining adequate quality of life.,0
"Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab.",1
"Radiotherapy has been the predominant treatment in the past, but more recently multi-modality treatments have been utilised.",0
Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.,1
"When platinum-containing agents are administered, patients should be closely monitored for hypersensitivity reactions, even in previously uncomplicated cases.",0
Hepatoxicity is a rare complication of SRL therapy and may be connected with some diagnostic and/or therapeutic problems.,1
The median time to progression was 3.9 months and the median overall survival time was 11.6 months.,0
Diffusion-weighted MRI (DWI) may help to distinguish between ischemic stroke and chemotherapy-related leukoencephalopathy.,0
Recurrent hyponatremia associated with citalopram and mirtazapine.,1
A number of studies have shown that hyperuricaemia is associated with an increased incidence of coronary heart disease.,0
RESULTS: The material from inside the lumen of the catheter was analyzed using x-ray spectroscopy and a scanning electron microscopy.,0
"A 4-year-old boy presented with fever, septic arthritis, and persistent neutropenia.",0
This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.,1
Interaction between tacrolimus and nefazodone in a stable renal transplant recipient.,1
"Thus, the patient's clinical course and workup strongly support a diagnosis of lenalidomide-induced hypersensitivity pneumonitis-like syndrome.",1
"CASE REPORT: The safety of combination therapy with nab-paclitaxel, an albumin-bound paclitaxel, and sunitinib, a tyrosine kinase receptor inhibitor, was evaluated retrospectively in three patients with advanced, previously treated metastatic esophageal cancer, non-small cell lung cancer (NSCLC), and small cell lung cancer (SCLC), respectively.",0
"This is the first reported case of BOOP associated with single-agent rituximab, and along with two other patients we describe, as well as two prior reports of BOOP in NHL patients receiving rituximab-based combinations, strengthens the possibility of a causal relationship.",1
The factors which may have predisposed to its development are reviewed.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
Methimazole-induced aplastic anemia in third exposure: successful treatment with recombinant human granulocyte colony-stimulating factor.,1
"In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.",1
"We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.",1
Successful management of infusion reaction accompanying the start of cetuximab therapy.,0
Aberrancies in T3 suppression testing in graves disease occur.,0
"Therefore, COX-2 inhibitors should be used with caution in renal transplant recipients and in patients with salt depletion and renal insufficiency.",0
Severe tardive dystonia: treatment with continuous intrathecal baclofen administration.,0
"FDE from cephalosporins has been rarely reported, and to the best of our knowledge there is no published report of ceftriaxone-induced FDE in the literature.",1
We studied this drug in a continuous ambulatory peritoneal dialysis (CAPD) and immunocompromised patient.,0
OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.,1
"After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.",1
"PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.",1
CASE SUMMARY: A 72-year-old white man was admitted for worsening palpable purpura over a two-day period.,0
"RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.",1
The most-common ocular symptom is colored rings around lights.,0
Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.,1
"The resulting increased turnover of heme might then result in overproduction of porphyrin precursors, resulting in the clinical syndrome.",0
"There was no statistically significant difference between the incidence of the total CNS complications among the different organ transplant groups (p value > 0.10), but there was a statistically significant difference in the systemic complications among the organ transplant groups (p value < 0.001).",0
"In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.",1
Heparin-induced thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement.,1
"Between March and May 1996, the patient was admitted several times to a neurology clinic, where myasthenia gravis was diagnosed and treatment with pyridostigmine and cyclosporine was initiated.",0
"We report the first case, to our knowledge, of rituximab-related autoimmune hemolytic anemia.",1
A case report.,0
"In conclusion, TVUS can fail to detect cancers if the endometrial lining is not enlarged.",0
Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.,1
A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).,1
"The vitreous body of an eviscerated eye was occupied by the non-specific granulomatous tissue, composed of fibroblast, plasma cells, and Sudan black staining positive foamy cells, including melaniferous phagocytes, identified as CD 68 positive macrophage.",0
Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.,1
Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.,1
Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.,1
Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.,1
"After discontinuing those drugs, the ST segment elevation in leads V(1) and V(2) became reduced.",0
Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.,1
Whitish papules on the palm.,0
Acute pancreatitis and amiodarone: a case report.,0
Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy.,1
Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.,1
"Thus, we believe that the combination of sodium thiosulfate with cinacalcet and paracalcitol is effective for the treatment of calciphylaxis with secondary hyperparathyroidism.",0
CONCLUSION: It is critical that oncologists remember that the theoretical benefits of available anti-neoplastic interventions must be carefully and constantly weighted against the potential harm they may cause.,0
"This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.",1
"PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.",1
Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia.,1
Drug-induced lymphocyte transformation test before desensitization was negative with a stimulation index of 130%.,0
The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.,1
Peripheral neuropathy associated with capecitabine.,1
The degree of clinical recovery related to maximal disability.,0
The attack was successfully treated with aggressive bronchodilator therapy.,0
Class effect of erythropoietin therapy on hemoglobin A(1c) in a patient with diabetes mellitus and chronic kidney disease not undergoing hemodialysis.,0
OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.,1
Most asthma drugs are inhaled using various forms of inhalers or nebulizers.,0
DATA EXTRACTION: Data from pertinent published sources were reviewed and abstracted.,0
"A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.",1
The computer-based algebraic method is illustrated for a problem previously analyzed by Monte Carlo simulation.,0
"Within 4 days of discontinuing the pentamidine, the patient's heart rate stabilized at 80 beats/minute without further intervention.",0
We recommend that a TMA in association with quinine be consistently referred to as quinine-associated thrombotic microangiopathy (quinine-TMA) to better distinguish this entity from idiopathic TTP.,1
"This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.",1
"Spinal epidural lipomatosis (SEDL), an abnormal localized or tumor-like accumulation of fat in the epidural space, is an infrequent complication of chronic steroid usage and an uncommon cause of spinal cord compression.",0
"Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.",1
"Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.",1
"Mild adverse cardiac and central nervous system effects are common with these medications, requiring modifications in dose or occasionally switching to a different medication.",0
"However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.",1
Intentional overdose with tiagabine: an unusual clinical presentation.,0
"G-CSF was used as an adjunctive therapy with discontinuation of carbimazole, barrier nursing and a broad-spectrum antibiotic regimen to treat her neutropenic sepsis.",0
"EEG with polygraphic recording may detect clinically inapparent tonic seizures in epileptics with unexplained confusion, and when generalized paroxysmal fast activity occurs during EEG recording.",0
This gave almost total resolution of the injury.,0
CONCLUSIONS: Neurologists have a vast armamentarium to treat both motor and nonmotor manifestations of PD.,0
BACKGROUND: To describe the occurrence of ocular hypertension in four patients following injection of ranibizumab intravitreally.,1
"These included advanced age, chronic lung disease, liver disease, and administration of cimetidine.",0
We describe a patient with M4 AML treated with standard chemotherapy followed by G-CSF who developed marked monocytosis on day 8 of G-CSF therapy.,1
Intermittent or interrupted therapy appears to be a significant risk factor for the development of this complication.,0
"Treatment of ELP in children is generally supportive, with the symptoms and roentgenographic abnormalities resolving within months after stopping the use of mineral oil.",1
"Apart from some minor discomfort at the site of operation, no side effects were noted.",0
Endovascular treatment of renal artery thrombosis caused by umbilical artery catheterization.,0
"To eradicate the infection, we performed two vitrectomies and treated the patient with numerous intravitreal antibiotic injections.",0
Protamine allergy as a complication of insulin hypersensitivity: A case report.,1
The child was on no other medication and had been previously well.,0
A 55-year-old woman who had been receiving treatment with amiodarone for recurrent supraventricular tachyarrhythmias became thyrotoxic after 30 months of treatment.,0
Traditional risk factor analysis and screening were performed.,0
"IMPLICATIONS: Switching from bupivacaine to lidocaine may improve intrathecal morphine analgesia in advanced cancer patients, possibly because of different spinal mechanisms limiting the hyperalgesic processes.",0
Lithium and ECT--concurrent use still demands attention: three case reports.,0
"Two patients were supported with a right VAD, one with a left VAD, and one with a biventricular VAD.",0
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
Development of neuroleptic malignant syndrome (NMS) following discontinuation of high-dose and high-potency neuroleptic agents is described.,0
Pre-treatment evaluation for the presence of arterial shunts to neighbouring organs should be determined in order to avoid complications of SIRT.,0
"Each case (stage IB and IA) occurred after initiation of the subcutaneous anti-tumor necrosis factor medications etanercept and adalimumab, respectively.",0
Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.,1
We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).,1
"Pantoprazole therapy was promptly discontinued, and prednisone 40 mg/d was initiated.",0
The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.,1
Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.,1
"Furthermore, this analysis does not provide evidence for a heightened risk of AML/MDS in CLL patients, despite treatment with known leukemogenic agents.",0
Rare side effects of nonsteroidal antiinflammatory drugs are recognized with increasing frequency.,0
He presented with multiple masses in the right lobe of the liver and a metastasis in the left adrenal gland.,0
"We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.",1
"Although porphyria cutanea tarda may be familial, it is more often sporadic in occurrence, and has been associated with excess alcohol ingestion, estrogen administration, iron overload, and several environmental hepatotoxins.",0
"Cytogenetic studies of the bone marrow performed after the development of acute leukemia showed chromosome abnormalities in all five patients examined, with hypodiploidy and loss of B and C group chromosomes.",0
"Recovery of the tubular dysfunction took 15 days following cessation of the offending drug, Amikacin.",1
"Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.",1
"After discontinuation of the drug, plasmapheresis and steroid therapy led to a sustained remission.",0
Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.,1
"CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.",1
Use of rituximab and irradiated donor-derived lymphocytes to control Epstein-Barr virus-associated lymphoproliferation in patients undergoing related haplo-identical stem cell transplantation.,0
These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.,1
Decompression sickness and arterial air embolism which follow exposure to raised environmental pressures of compressed air are usually adequately treated by accepted recompression procedures of relatively short durations.,0
Using a ventricular reservoir to instill amphotericin B.,0
"As the patient's pulse rate increased, the symptoms of congestive heart failure disappeared.",0
METHODS: Four solid organ transplant patients with severe hypoxemic P. jiroveci pneumonia were treated with the combination of trimethoprim-sulfametoxazole and caspofungin.,0
"After three months, 17 (74%) out of 23 eyes showed a significant low endothelial cell count compared to the normal fellow eye ( P 0.001).",0
"A 27-year-old man with acute monoblastic leukemia had clinical and laboratory evidence of disseminated intravascular coagulation (DIC), which was exacerbated by induction chemotherapy.",0
A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate.,1
Close patient monitoring is advisable in these types of patients.,0
Monitoring and predicting ototoxic damage using distortion-product otoacoustic emissions: pediatric case study.,0
The clinical presentation and management of a newborn whose mother received lithium during pregnancy is presented.,0
Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.,1
"Here we report the case of a 43-year-old Japanese woman with acute myelogenous leukemia who underwent 2 unrelated cord blood transplantations (UCBT), terminating in fatal disseminated tuberculosis (TB).",0
"Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.",1
A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.,1
Edema disappeared two to three days after stopping therapy but reappeared in all five patients after being reexposed to the drugs.,0
"With the increasing use of immunosuppressive agents, including TNF alpha inhibitors, it is likely that there will be an increase in the number of mycobacterial infections complicating arthroplasties.",0
"However, with increased experience in applying BCG, the side effects now appear to be less prominent and few.",0
"Also, it appears that these patients may be more susceptible to complications with future disulfiram usage and should be strongly counseled to seek alternative therapies for their alcohol problems in the future.",0
We report two patients with acquired fistulas between the internal mammary and pulmonary arteries after coronary bypass surgery.,0
"RESULTS: Among a total of 3,648 ICD-related procedures performed between 1983 and 2005, we identified 47 (1.3%) cases of ICD infections, of which 5 (0.1%) were due to a fungal pathogen.",0
"CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.",1
"In all three cases, an alleviation of headache intensity from severe to moderate was observed.",0
OBJECTIVE: To investigate the mechanisms involved in hypersensitivity reactions to cyclosporine and determine the feasibility of future cyclosporine use.,1
"While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.",1
"Diltiazem therapy was discontinued, leading to resolution of fever within 48 hours.",0
Capecitabine (CAP) is a pro-drug of 5-FU and peripheral neuropathy associated with CAP has not been reported.,0
"In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.",1
METHODS: Two patients with exudative age-related macular degeneration were treated sequentially with an intravitreal injection of bevacizumab and developed signs of severe but painless infectious endophthalmitis 2 days later.,1
Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.,1
Unusual weight fluctuation under corticosteroid and psychotropic treatment.,0
"We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.",1
Diagnosis: practolol induced sclerosing peritonitis.,1
"The patient's INR had been stable and within therapeutic range (goal 2.0-3.0) for the previous 3 months with warfarin 27.5 mg/wk, but became subtherapeutic after 10 days of bosentan therapy.",0
"Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.",1
The relationship between tardive OGC and clozapine is still unknown.,0
Our case is the second one in which hemorrhage from a meningioma may have been induced by aspirin prophylaxis.,1
"A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.",1
Remission of clinical signs in early Duchenne muscular dystrophy on intermittent low-dosage prednisolone therapy.,0
"Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.",1
Medication can induce severe ulcerations.,0
"The primary outcome (behavioural disturbances) was measured prospectively by the Neuropsychiatric Inventory (NPI), while other outcomes included cognition (Mini-Mental State Examination (MMSE)) and Clinical Global Impression.",0
"After forty-eight hours, he developed jaundice and transaminasemia, which subsided by the eighth day.",0
A 2-month course of sucralfate and cimetidine was used and successfully produced symptomatic relief as well as complete normalization of the dysplastic changes.,0
"Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.",1
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
"A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.",1
The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.,1
Sixteen of 33 patients developed significant hyponatremia and hypoosmolality during oral treatment with lorcainide.,1
It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.,1
"The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.",1
Infliximab and nephrotic syndrome.,0
Methylphenidate hydrochloride (Ritalin) is the drug of choice for attention deficit hyperactivity disorder (ADHD).,0
Transient acute myopia resulting from isotretinoin (accutane) therapy.,1
"Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.",1
"A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.",1
D-penicillamine induced crescentic glomerulonephritis: report and review of the literature.,1
Stevens-Johnson syndrome and toxic epidermal necrolysis: consequence of treatment of an emerging pathogen.,0
Aortic transgraft hemorrhage is an unusual complication following thrombolytic therapy that can occur months to years after aortic surgery.,0
"CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.",1
We believe this case represents a rare complication of anticholinergic therapy.,0
"Linear IgA bullous dermatosis has a much lower prevalence of histological small bowel abnormalities, and lesions are not known to respond to gluten restriction.",0
"These differences necessitate close monitoring of hypothyroid patients, counseling these patients about the clinical signs of sub- and supratherapeutic levothyroxine dosages, and prudence when switching patients with stable hypothyroidism to alternative levothyroxine products.",0
Black cohosh and other herbal remedies associated with acute hepatitis.,0
A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF.,1
"Despite these changes, the sensitivity of the mutant virus to zanamivir assessed by a standard test in MDCK cells was unaffected.",0
The increasing number of Latinos in the United States and the extensive cross-border transfer of medicines raise concerns that metamizole use and associated complications may become more frequent.,0
Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.,1
Mycobacterium bovis dissemination (BCG strain) among immunodeficient Brazilian infants.,0
"The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.",1
"In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.",1
We report a case of pediatric bupropion ingestion resulting in multiple seizures.,1
"These children aged 2.5-15 years were treated for Burkitt's lymphoma, Ewing's tumour, small cell bone tumour or medulloblastoma.",0
We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).,1
We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.,1
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia.,1
Albuterol-induced hypokalemia and its potential cardiac toxicity are discussed briefly.,1
Primary herpes virus keratitis after penetrating keratoplasty.,0
Severe akathisia during olanzapine treatment of acute schizophrenia.,1
Perforated appendicitis and ectopic pregnancy following in-vitro fertilization.,0
"Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.",1
"For the treatment of visual loss, differential diagnosis is important between infection and adverse effect of anti-tuberculous drugs.",0
Cholestyramine induced hyperchloremic metabolic acidosis.,1
"Treatment was continued for 6 days, during which the dosage was progressively decreased, and the mare was discharged.",0
Gastrointestinal (GI) tract disease is an unusual presentation of this yeast infection.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"Treatment with protease inhibitors in some persons infected with HIV-1 is associated with a syndrome of lipodystrophy manifesting as peripheral lipoatrophy, relative central adiposity, insulin resistance, and serum lipid abnormalities.",0
"Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.",1
Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations.,1
"However, as the use of hepatitis B vaccination is growing, adverse side effects, including mental nerve neuropathy, should be observed with an increased frequency.",1
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"Several different criteria for diagnosis exist, and each differs from the others slightly.",0
"The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.",1
Prolonged severe 5-fluorouracil-associated neurotoxicity in a patient with dihydropyrimidine dehydrogenase deficiency.,1
RESULTS: A 69-year-old Saudi man underwent penetrating keratoplasty with donor tissue that was culture-positive for Candida glabrata.,0
"Temporal sequence of his signs and symptoms after each administration of tobramycin (similar to re-challenge testing), and his improvement after discontinuation of the drug strongly suggest an adverse drug reaction.",0
The rapid development of pulmonary aspergillosis associated with the formation of an Aspergillus mycetoma should be attributed to the loss of normal immune mechanisms due to immunosuppressive treatment.,0
Thus cabergoline may cause similar pleuropulmonary abnormalities to bromocriptine.,1
"We examined the in vitro inhibition of the clonogenic capacity of bone marrow hematopoietic progenitor cells of this patient by D-Pen, and found strong inhibition in burst-forming unit-erythroid and colony-forming unit-megakaryocyte assays, but not in colony-forming unit-granulocyte/macrophage assays.",0
"Additional drugs present included hydrocodone and morphine (nonconjugated) at 0.16 and 0.04 microg/mL, respectively.",0
Clinicians should be aware of this potential adverse effect of a widely used drug.,0
This resulted in clinical improvement and controlled the progression of hemolysis and methemoglobinemia.,0
"We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.",1
"CMV reactivation is frequently observed in acute flares of ulcerative colitis (UC), particularly those which do not respond to intravenous steroids.",0
"The entity is likely more common than the paucity of reports in the world literature suggests, and all physicians should recognize its graphic appearance to avoid unnecessary exposure to agents in an effort to treat it.",0
"Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.",1
Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.,1
CONCLUSIONS: The administration of prostaglandin E1 to neonates can cause gastric-outlet obstruction due to antral hyperplasia.,1
"Most adverse events are due to an infusion-related symptom complex, and severe pulmonary complications are rare.",0
"Common adverse reactions of immunosuppressive treatment are infections, hematologic and liver function abnormalities, but neurologic complications may also be seen.",0
These observations support the view of an increase in both the severity and incidence of PCP in patients without human immunodeficiency virus infection and question the need for a primary prophylaxis in patients with connective tissue diseases receiving high-dose corticosteroid therapy.,0
"Just over 1 year following completion of his treatment, falling platelet and white cell counts were associated with the development of dysplastic features in his bone marrow and a rising blast cell count, culminating in the development of acute myeloid leukemia (AML).",0
OBJECTIVE: To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections.,1
"We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.",1
An unusual response to progestin therapy of hyperplasia.,0
"To our knowledge, this case report is the first documentation of a second PSA bump in a patient treated with external-beam radiation therapy and high-dose rate boost therapy and provides context to address concerns and therapeutic decisions confronting physicians and patients.",0
Risk factors present for acquired long QT syndrome were mineral dysbalance and a history of alcohol abuse with hepatic impairment.,0
Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.,1
"We also describe a new, noninvasive method to assess magnesium-induced neuromuscular block when curariform muscle relaxant was given simultaneously.",1
"Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.",1
It helps to reduce the serious toxic side effects of calcineurin inhibitors (CNIs).,0
Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.,1
Clinical toxicity of reserpine in hospitalized patients: a report from the Boston Collaborative Drug Surveillance Program.,0
Six patients with chronically recurrent oculogyric crises (OGC) are reported.,0
OBJECTIVE: To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2.,1
"A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.",1
A cytogenetic study showed del (3)(q11.1).,0
We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.,1
Caution is emphasized in the use of carbonic anhydrase inhibitors in patients with obstructive airway disease.,0
The patient died approximately 6 months later of persistent and progressive retinoblastoma without any clinical evidence of lymphoma.,0
Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses.,1
"A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.",1
The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain.,1
Gliclazide-induced acute hepatitis.,1
CASE: A patient was admitted to hospital with preterm contractions and cervical insufficiency at 28 weeks of gestation.,0
The Hybrizep method (which is available on the Japanese National Health system only for the diagnosis of septicemia) was a useful diagnostic approach for a patient on peritoneal dialysis who had peritonitis.,0
"For 4.5 months after surgery, the bird had no recurrence of clinical signs; however, dyspnea recurred and during evaluation, the bird died.",0
A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.,1
Risperidone-induced psychosis and depression in a child with a mitochondrial disorder.,1
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
METHOD: The case histories of three geriatric patients treated with fluoxetine for depression or obsessive compulsive disorder are presented.,0
Pertinent literature was reviewed to provide supporting evidence for the mechanism and clinical implications of the drug interaction.,0
"Liver biopsy revealed a reduction in activity of carbamyl phosphate synthetase-I, an enzyme obligated for transformation of ammonia to urea in the urea cycle.",0
"On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.",1
MATERIALS AND METHODS: We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin.,1
We report details of two liver transplant procedures in which post-reperfusion coagulopathy was reversed by administration of protamine sulphate.,0
We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.,1
"Other pharmacologic interventions, based on the physiology of erections, are presented.",0
"After four months, while receiving RH, he developed painful bilateral gynaecomastia.",1
"Because of life threatening plasma methotrexate (MTX) levels, carboxypeptidase G2 (CPDG2) was administered resulting in a dramatic decrease within 1 hr.",0
Disseminated tuberculosis following second unrelated cord blood transplantation for acute myelogenous leukemia.,0
Altered drug pharmacokinetics should be considered as an important metabolic consequence of subtotal gastrectomy.,0
"In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.",1
"However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.",1
Methemoglobinemia is a rare cause of cyanosis in pediatric patients.,0
Suppression of endogenous cortisol production and replacement with more physiologic concentrations of glucocorticoid were associated with clinical improvement and appeared to contribute to her recovery.,0
We report a case of papillary necrosis in a patient treated with indinavir.,1
She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.,1
"Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.",1
The effusion resolved after the withdrawal of the drug and the beginning of anti-inflammatory therapy; there was no relapse during a 10-month follow-up.,0
The following is a case report of a 32-year-old man who experienced refractory bronchospasm upon emergence from general anesthesia.,0
Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.,1
RESULTS: All cases developed corneal endothelial deposits after previous use of rifabutin.,1
This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.,1
Opioid drugs cause bile duct obstruction during hepatobiliary scans.,0
CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy.,1
Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.,1
Stent fracture: an unusual cause of late restenosis after sirolimus-eluting stent placement.,0
The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome.,0
"In association with this tocolysis, urinary calculus of magnesium ammonium phosphate occurred at 34 weeks gestation.",1
"We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.",1
OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.,1
"He died 1 month later in spite of methylprednisolone pulse therapy, large spectrum antimicrobial therapy, and full support of respiratory, hemodynamic and renal systems.",0
"Although tandem scanning confocal microscopy of Acanthamoeba has been described in previous reports, Acanthamoeba keratitis has not been fully characterized with this instrument.",0
"Bradycardia, hypotension, respiratory distress, and, ultimately, cardiopulmonary arrest occurred in both.",0
None of the patients required treatment for the overdose.,0
"In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.",1
"Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.",1
We report a case of IDDM which occurred during interferon therapy for chronic hepatitis.,1
OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.,1
The treatment was discontinued and after 2 months the liver parameters became normal.,0
"At 8 years 1 month of age, phenytoin was first administered.",0
Viscoelastic material as an adjunct to dissections and to treat microperforations during nonpenetrating filtering surgery.,0
"In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.",1
"Brain MRI revealed lesions in the thalamus and the brainstem, particularly the tegmentum, and the basis pontis in addition to the basal ganglion lesions.",0
"Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.",1
One patient showed mild improvement (42.0% decrease in VAS).,0
We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.,1
A study protocol to manage these patients within a multidisciplinary team including also specialists in infectious diseases and virologists is mandatory.,0
"Ptosis occurring 24 h after chloroquine therapy, with full recovery 48 h after cessation of chloroquine, has not been described previously.",1
It is too early to evaluate four patients at present.,0
"The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis, and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities, the combination use of these drugs should be avoided.",1
"Many symptoms of hyperthyroidism are identical to the adverse effects of the commonly used inhaled bronchodilators and include tremor, nervousness, tachycardia, wide pulse pressure, palpitations, emotional lability, agitation, nightmares, aggressive behavior, and diarrhea.",0
"The optic neuropathy subsided only when both drugs were discontinued, suggesting an additive toxic effect.",0
"The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.",1
"Methamphetamine's extensive physiologic effects, inconsistent street purity, and multiple routes of administration offer many possibilities for injury to the cornea.",1
Kluver-Bucy syndrome: report of a case with nasopharyngeal cancer after irradiation and chemotherapy.,0
This may lead to misdiagnosis as migraine and delayed appropriate diagnosis and treatment.,0
A case of severe aplastic anemia secondary to treatment with lenalidomide for multiple myeloma.,1
"Three months following splenectomy, multiple abscesses occurred in the muscles of both thighs while the patient was receiving the third course of the CHOP regimen.",1
Serotonin syndrome is an underreported complication of pharmacotherapy that has been relatively ignored in the medical literature.,0
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
Abemayor).,0
Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction.,1
Rapid warfarin reversal with factor VIIa in an elderly trauma patient with retroperitoneal hematoma.,0
That time the only effective treatment was ventricular pacing.,0
We plan to do a Holter study during the period of bradycardia in subsequent patients and this may throw more light on the issue.,0
We report on successful liver transplantation in a patient with CSD who suffered from chronic hepatitis C.,0
The child had a history of heart disease treated with digoxin.,0
This case highlights many key points for treatment of psoriasis and psoriatic arthritis with biologics.,0
"The day after methotrexate administration, the patient complained of severe back pain and urinary retention.",1
CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer.,1
The diagnosis of thrombotic obstruction of the prosthetic mitral valve was confirmed by transesophageal echocardiography.,0
This effect of cisapride is presumably related to its serotonin3 antagonistic property.,0
PURPOSE: The occurrence of myoclonus associated with continuous i.v. infusion of dobutamine in a patient with end-stage renal disease (ESRD) is described.,1
Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome.,1
"The reporting rate for angioedema was calculated to be 9.8 cases per 1,000,000 pediatric patients.",0
This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.,1
Complete resolution of symptoms within 1-4 days was accompanied by normalization of ADC abnormalities.,0
"This case is reminiscent of pneumonitis to other beta-blockers, which are reviewed here.",0
"This therapeutical regimen was chosen--in accordance with cardiac surgeons, cardiologists, and interventional radiologists--due to the high risk of adverse event after repeated surgery in this particular patient.",0
Steroid diabetes in children with Crohn disease.,0
"Since July 1985, 23 patients have been entered into a phase I/II clinical trial using intraarterial 5-bromodeoxyuridine (BUdR) (400-600 mg/m2 daily for 8.5 weeks) and focal external beam radiotherapy (59.4 Gy at 1.8 Gy daily in 6.5 weeks) in the treatment of malignant gliomas (Kernohan grades 3 and 4).",0
Is it quinine TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapy.,0
Radiation-induced bilateral optic neuropathy in cancer of the nasopharynx.,0
Persistent ashen-gray maculae 5-7 mm in diameter and freckles developed after prolonged PUVA therapy of psoriasis.,0
Delayed onset diffuse lamellar keratitis following enhancement LASIK surgery.,0
"Both were alcoholic, malnourished and presented with radiologically widespread, smear-positive disease and lymphocytopenia.",0
People who become dependent on these mixtures commonly do not present for medical assistance until the problem is severe.,0
Garlic burns.,0
These changes were associated temporally with cyproheptadine dosing.,0
Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin.,1
"Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as ""red man syndrome"" and anaphylaxis.",1
Diclofenac and increasing doses of opioids did not give adequate pain relief and led to opioid toxicity.,0
Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.,1
Thalidomide was withdrawn from world markets in 1961 following recognition of its teratogenic effects.,1
Five patients experienced increased intraocular pressure to 30 mmHg or greater which required treatment.,0
"A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.",1
Its disadvantage is that therapy may be necessary for several months.,0
"Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.",1
Case report of withdrawal dyskinesia associated with amoxapine.,1
"A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.",1
"Moreover, the etiology of t-AML and mechanism of leukemogenesis are likely to be multifactorial and complex.",0
"Our treatment consisted of assisted ventilation with intubation, accompanied by calcium chloride infusion and forced diuresis with mannitol.",0
"We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.",1
Priapism as a complication of heparin therapy.,1
Continued occurrence of Accutane-exposed pregnancies.,0
We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.,1
We report the first case of a tuberculous cutaneous lesion in a patient receiving the above treatment.,0
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
"She developed skin changes, diabetes mellitus, heart disease, recurrent infections, generalized joint and abdominal pains and liver failure.",0
DIAGNOSIS: Sustained ventricular tachycardia possibly owing to thalidomide treatment.,1
"Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.",1
Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.,1
Heparin-induced hyperkalemia.,1
"The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.",1
"Colchicine-induced rhabdomyolysis is a rare complication, and the postulated mechanisms and risk factors for this severe complication are discussed.",1
"We describe a 49-year-old woman who presented in 2002 with pure red cell aplasia (PRCA), systemic lupus erythematosus (SLE), and idiopathic portal hypertension (IPH) that developed following a thymectomy.",0
"Withdrawal syndromes, delirium tremens in particular, are known to cause delirium.",0
"This compound, used by adults in the child's home, had caused accidental theophylline poisoning, mimicking diabetic ketoacidosis.",1
The first organism is exceptionally rare following laparoscopic cholecystectomy and is presumed to be a result of inadvertent gallstone spillage.,0
In all three patients a decrease in anti-DNA antibody levels and an increase in total complement hemolytic activity were detected after therapy.,0
Voriconazole (VRC) has not previously been reported to cause angio-oedema.,1
Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.,1
These lesions developed within the port site during the radiation treatments (11 cases) or soon after (nine cases) its completion (mean: 16 days; range: 2-35).,0
The remainder of the procedure was uneventful.,0
"DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.",1
"To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.",1
"The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.",1
Massive pulmonary embolism complicating streptokinase treatment for deep vein thrombosis.,1
Erosion of psoriatic plaques: an early sign of methotrexate toxicity.,1
The authors report one case of incomplete posterior hyaloid detachment (PHD) following intravitreal pegaptanib to treat DME.,1
Severe abdominal pain in low dosage clofazimine.,1
"This agent is, however, associated with a rare but serious risk of lactic acidosis.",0
Pulmonary hypertension during lithium therapy: clinical case study.,1
Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.,1
We report a case of peritonitis in a patient on continuous ambulatory peritoneal dialysis caused by Listeria monocytogenes.,0
Secondary leukemia with a translocation (8;21)?,0
RESULTS: The patient had complete paraplegia develop within 12 hours from admission following a 1-day history of unsteady gait and a 3-day history of leg numbness.,0
Glycopeptide-induced neutropenia: cross-reactivity between vancomycin and teicoplanin.,0
Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.,1
"Within 2 weeks after starting azithromycin, the patient's forced expiratory volume in 1 second increased significantly and a repeat spiral CT chest scan 5 months later, showed a major improvement of the bronchiectasis.",0
The case of a 39-year-old woman who was referred for weight gain and amenorrhoea is reported.,0
Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.,1
Three patients developed proteinuria following gold therapy for rheumatoid arthritis.,1
"To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.",1
The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin.,1
"Disseminated encephalomyelitis (DEM) is an inflammatory demyelinating disease that is common in children, but also appears in adults.",0
We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.,1
"A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.",1
"Physical exam revealed a patient with aphasia, tremor, and an expressionless face, able to make eye contact and move all four extremities.",0
A lasting change in trazodone response after non-convulsive electroshock therapy for medication-resistant senile depression.,0
An urgent brain computed tomographic scan showed hemorrhage in the right cerebellum and subarachnoid region.,0
We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.,1
"Lymph node biopsy showed almost complete effacement of the nodal architecture with diffuse proliferation of small vessels forming an arborizing network, surrounded by atypical lymphocytes, usually CD3+ CD4+ and occasionally CD3+ CD8+.",0
The introduction of para-aminosalicylic acid (PAS) led to hypoglycaemic coma.,1
"Three possibilities existed to account for this outbreak: the positive cultures represented isolated events; there was one isolated event and a common source; or, all events were due to a common source.",0
We report a case of tularemia presenting as a solitary pulmonary nodule following syngeneic PBSC transplant.,0
Severe bleomycin lung toxicity: reversal with high dose corticosteroids.,1
Teicoplanin-induced agranulocytosis that followed vancomycin-induced agranulocytosis suggests a possible cross-reactivity between the 2 drugs.,1
"Shortly after chemotherapy and an injection of pegfilgrastim, the patient developed poorly defined, rapidly progressive erythema, edema, and pain in his right forearm.",1
"Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or ""cutting"" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.",1
RESULTS: Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.,1
This is despite relatively poor clearance of the drug through peritoneal dialysis.,0
"She developed a febrile illness associated with severe pancytopenia and leukocytoclastic vasculitic rash followed by diffuse adenopathy, with serologic and pathologic evidence of EBV infection.",0
"However, 8 hrs after extubation, she gradually developed severe respiratory distress, requiring reintubation and mechanical ventilation.",0
Her case was complicated by social and behavioral issues.,0
"In two of the cases, the patients had documented histories of vascular disease, which their internists had identified as the cause of their impotence.",0
"We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.",1
"Despite the prophylaxis and preemptive strategies using potent antiviral agents, cytomegalovirus (CMV) remains a major infectious cause of morbidity and mortality in allogeneic stem cell transplantation (SCT) recipients.",0
AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.,1
"On the basis of this experience, the authors point out that in the course of acute respiratory failure in leukemic children, the combination of a negative chest X-ray and a positive pulmonary perfusional scintigraphy (compared whenever possible with ventilatory scintigraphy) in the presence of a negative CT scan could be a reliable diagnostic tool for PTE.",0
These experiments have confirmed clinical observations that alcohol in modest doses has the potential of producing atrial or ventricular arrhythmias.,0
CASE SUMMARY: A 16-day-old infant developed several mild episodes of apnea that culminated in a severe cyanotic episode requiring resuscitation.,0
"In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.",1
Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.,1
We report the case of a 19-year-old woman who developed PVOD accompanied by microangiopathic hemolytic anemia (MAHA) and hemolytic uremic syndrome (HUS) 1 year after a second BMT for relapsed acute lymphoblastic leukemia (ALL).,0
"New observations, including CT scan findings and experience with treatment by praziquantel.",0
Apparent central nervous system depression in infants after the use of topical brimonidine.,1
"Ours is a 430-bed tertiary care teaching hospital, The Wellesley Hospital, Toronto, Ontario.",0
"Cutaneous rashes and eruptions can be caused by many medications, including carbamazepine.",1
PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.,1
"Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.",1
Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.,1
"Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.",1
Contact dermatitis treated with new topical products: a case study.,0
An issue under much clinical debate is whether treatment with two antipsychotic agents simultaneously is advantageous for optimizing response in patients whose previous monotherapy with antipsychotic agents has failed.,0
"Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).",1
Disabling errors of skin keratinization.,0
One victim was hospitalized.,0
"In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.",1
Disodium cromoglycate is regarded as the possible aetiological agent.,0
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
Oesophageal ulceration due to emepronium bromide.,1
"A urinalysis was significant for protein 3061 mg/dl, ketones 15 mg/dl, blood 2+, leukocytes 26-50/high-power field, and a protein:creatinine ratio 24.9.",0
"After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.",1
"Bronchiolitis obliterans (BO) in children is a rare, inflammatory/fibrosing process involving the small airways that often results in progressive, irreversible obstructive pulmonary disease.",0
Arthritis and bursitis in multiple sclerosis patients treated with interferon-beta.,1
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
These potentially life-threatening phenomena have led to treatment discontinuation and the consequent reemergence of psychiatric symptoms.,0
Methotrexate induced sprue-like syndrome.,1
Triazolam-induced nocturnal bingeing with amnesia.,1
A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described.,1
"The case of a young woman suffering from multiple autoimmune-dysreactive disorders (including thyreoiditis, myasthenia gravis, thymectomy, Crohn's disease, and erythema nodosum), while undergoing steroideal therapy, was complicated by a severe infectious disorder (severe upper urinary tract infection).",0
"This is an interesting case because the proarrhthmia of the drug was not tachyarrhythmia, such as ventricular tachycardia or torsades de pointes, but sinus pause.",0
Rickets in low birth weight infants receiving total parenteral nutrition.,0
"MR of the brain was performed in eight patients (mean age, 14.9 years) with osteogenic sarcoma during or after IV treatment with high-dose methotrexate.",0
"Stellate ganglion block is utilized in the diagnosis and management of various vascular disorders and sympathetically mediated pain in the upper extremity, head and neck.",0
DISCUSSION: The causal association between anticoagulant therapy and spontaneous hemothorax remains relatively uncommon.,0
Sunburn may sometimes be a major injury in psoralen users because high doses or inappropriate use of the drug may render the skin extremely sensitive.,1
"We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.",1
Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation.,0
"Of those 18 patients who completed a full course of therapy, seven (39%) experienced a relapse; five of these were cured of their infection with a second course of antimicrobial therapy, which usually included higher doses of intravenous penicillin.",0
"The evidence linking disorders of anger and impulse control to a dysregulation in neurotransmitter regulation, particularly in serotonergic pathways, supports a psychopharmacologic approach to treatment.",0
"Since epithelial downgrowth involves an actively proliferating intraocular tissue, it is possible that the antimetabolite 5-fluorouracil may inhibit it.",0
"Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.",1
"In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.",1
"Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.",1
"The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.",1
"Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.",1
Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.,1
Carbamazepine-induced Diabetes mellitus.,1
"The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.",1
"Possible explanations of this ocular effect are offered: pharmacokinetic interference on the drugs used in glaucoma treatment, in vivo action on the muscarinic receptor, indirect effect via dopaminergic receptors, or direct effect on the ocular sympathetic postganglionic neurones.",0
Both premortem and postmortem bone marrow sampling revealed almost complete replacement of the marrow space by sheets of histiocytes demonstrating metachromatic cytoplasmic granules.,0
We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.,1
Ampicillin may aggravate clinical and experimental myasthenia gravis.,1
The pacing system consists of an implanted receiver-lead system and an external patient-activated transmitter.,0
"The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented.",1
"One day later, the INR was found to have decreased, and bleeding was also improved.",0
"The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.",1
"Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome.",1
Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.,1
Case report and literature review.,0
"The diagnosis was made on the classical appearance of ""owl's eye"" inclusion bodies on colonic and hepatic biopsies and, in addition, viral serology and polymerase chain reaction (PCR) analysis of the cytomegalovirus DNA copy number.",0
"The abscess was surgically drained, the IUD removed, and a prolonged course of amoxycillin/clavulanic acid given.",0
Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis.,1
"Hereditary motor and sensory neuropathy type 1 (HMSN-1) is an autosomal dominant disorder, which is usually not associated with neoplastic diseases.",0
The patient became cyanotic with a PaO2 of 39 mmHg.,0
"OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.",1
"Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.",1
"When measured, the serum lithium level had increased 4-fold during acyclovir therapy.",1
Meperidine-associated central nervous system (CNS) excitatory toxicities are believed to be caused by accumulation of the active metabolite normeperidine.,1
"Direct immunofluorescence revealed staining at the dermal-epidermal junction and around blood vessels with IgG in the first case and with IgG, IgA, and fibrin in the second case.",0
"Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.",1
Gynaecomastia is a rarely reported adverse drug reaction due to isoniazid therapy.,1
BACKGROUND: Headaches have been reported as a potential side effect of capecitabine therapy.,1
There was no previous history of seizure disorder and he was on no other medications.,0
"During FAB-treatment total DGTX serum concentrations and renal DGTX clearance rose, indicating redistribution of drug from tissue to serum and urinary elimination of FAB-bound DGTX, respectively.",0
We described the occurrence of L-dopa-induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.,1
Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.,1
"The clinical, biochemical, and, finally, genetic evaluation confirmed Wilson's disease diagnosis in this patient.",0
"The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).",1
METHOD: Clinical and radiological observations during a rehabilitation program.,0
"Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.",1
The dog was treated with a combination of systemic antifungals and weaning off immunosuppressants and made a complete recovery.,0
Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.,1
Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.,1
The infection was successfully managed with liposomal amphotericin B and functional endoscopic sinus surgery.,0
"Thus, the risk appears to be confined to women over 50 because, in contrast, in women under 50 there was no statistically significant increase in the risk of endometrial carcinoma.",0
Spinal cord compression induced by steroid therapy: CT findings.,0
Allopurinol may be an effective treatment for granulomatous reactions to foreign body particles.,0
"He was treated with oral ibuprofen 600 mg every 6 h and oral cyclobenzaprine 5 mg daily, which improved his pain, but the shoulder stiffness remained throughout his hospital stay and persisted for 2 months following discharge.",0
Reduction of tumor burden and stabilization of disease by systemic therapy with anti-CD20 antibody (rituximab) in patients with primary cutaneous B-cell lymphoma.,0
Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.,1
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
The patient was hospitalized and treated with a bolus as well as continuous infusion of intravenous magnesium sulfate.,0
Nephrotic range pseudoproteinuria in a tolmetin-treated patient.,1
"The combination therapy resulted in abrupt alleviation of psychotic symptoms in one of the cases, and maintenance with low-dose clozapine allowed for long-term efficacy.",0
"Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.",1
"Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.",1
Thrombolysis was administered and the patient recovered uneventfully.,0
"Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.",1
"METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.",1
Iatrogenic vasculitis should be suspected when a patient with idiopathic vasculitis with one type of ANCA develops the other type of ANCA.,0
"To our knowledge, this is the first case reported in the English literature of a generalized exanthem due to subcutaneous injection of enoxaparin.",1
Bronchiolitis obliterans organizing pneumonia simulating progression in bronchioloalveolar carcinoma.,0
"The patient presented to the emergency department with a few weeks' history of irritability, constipation and intermittent vomiting.",0
He has elected to have future SBCCs managed with C&C.,0
Plasma exchange with either fresh-frozen plasma or 5% albumin solution as replacement fluid was performed in four selected patients with juvenile rheumatoid arthritis unresponsive to standard therapy.,0
Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia.,1
"Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.",1
"We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.",1
Carbamazepine-induced systemic lupus erythematosus-like disease.,1
We reviewed the records of 3 patients with lymphoproliferative disorders who experienced acute coronary syndromes associated with their initial infusion of rituximab.,1
BACKGROUND: reports on delated cutaneous reactions to captopril have been seldom reported.,1
We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.,1
"Although renal function showed gradual improvement after seven days of anuria, the recovery was slow and incomplete.",0
Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.,1
Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.,1
Clinical and biochemical abnormalities disappeared soon after discontinuation of PTU.,0
"The availability of atypical antipsychotic agents represents a significant step forward for those patients who are nonresponsive to conventional antipsychotics, offering proven efficacy, a lower risk of extrapyramidal symptoms, and improved clinical outcomes.",0
The findings are based on liver histology and the exclusion of other causes of liver damage.,0
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
Remission of lymphoma after drug withdrawal in rheumatoid arthritis.,0
"Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.",1
"A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.",1
"We also report, for comparison, a patient treated with conventional AmB, and preliminary studies in mice comparing the two agents.",0
"The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.",1
Potential mechanisms involved in the occurrence of ischemic colitis in patients receiving tegaserod are also discussed.,1
"We report a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis, in whom the withdrawal of cyclosporin A induced a generalised pustular exacerbation and a aggravation of the joint condition.",1
Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm.,0
A 68-year-old male was admitted for interstitial pneumonia associated with scleroderma.,0
"BACKGROUND: Mycophenolate mofetil (MMF) is a potent, safe immunosuppressive agent for rescue therapy of acute and chronic rejection in orthotopic liver transplant recipients.",0
The aim of this report is to describe the clinical and electroencephalographic findings seen in an elderly woman without previous history of seizures who developed a nonconvulsive generalized status epilepticus following acute withdrawal of lorazepam.,1
"The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.",1
"Since recent studies have reported no negative interactions with concurrent use, we here report three cases (one case of a prolonged seizure, a serotonin syndrome and a focal seizure) of severe lithium-induced side effects while patients underwent ECT without complications and lithium serum levels were still subtherapeutic.",1
"When retested 3 months later, at which time the serum T4 was 5.5 micrograms/dl, the patient was somewhat less hypothyroid and there was an exaggerated TSH response to exogenous TRH, indicating recovery of pituitary TSH reserve.",0
"The patient responded to gluten restriction, as shown by resolution of jejunal abnormalities and skin lesions and subsequently by recurrence of jejunal abnormalities and skin lesions with reinstitution of a gluten-containing diet.",0
We review the 14 previous cases published in the literature and describe two additional patients.,0
"The four other North American cases are reviewed, and the epidemiology of the infection in animals is discussed.",0
The abscess was treated with aspiration and appropriate antibiotic therapy and its complete resolution was confirmed by CT scan.,0
Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.,1
We believe this is the first report of intrathecal diamorphine causing anaphylaxis.,1
"Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.",1
Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.,1
"It also illustrates the need for continued clinical evaluation of patients with metastatic prostate cancer, even in the face of PSA response.",0
We report an unusual case of a leiomyosarcoma of the urinary bladder after chemotherapy for retinoblastoma and the results of a review of the published reports of bladder sarcomas.,0
Some patients develop hypersensitivity rash in response to HCQ.,1
Long-term clinical outcome after accidental overdose of multiple chemotherapeutic agents.,0
A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.,1
Myelodysplasia terminating in acute myeloid leukemia in a hairy cell leukemia patient treated with 2-deoxycoformycin.,1
"RESULTS: Three patients (one woman, two men) with a mean age of 76.3 years developed neovascularization at the L-CRA site and underwent treatment as described with a mean follow-up time of 7 months.",0
"Metamizole, a nonsteroidal antiinflammatory agent, is prohibited in the United States because of the risk of agranulocytosis but is widely used in Mexico and other countries.",1
"If untreated, or misdiagnosed and treated incorrectly, there may be loss of visual acuity.",0
"Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued.",1
We have found no reports describing a technique for making custom hand-made articulating spacers.,0
We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.,1
"Seizures were controlled by the anticonvulsive agent Dilantin (Pfizer, Khet Klongtoey, Bangkok) and she returned home without any permanent neurologic deficits.",0
"After aprotinin infusion (loading dose of 2 x 10(6) kIU followed by a continuous infusion of 5 x 10(5) kIU/h) combined with heparin, bleeding vanished until the end of bypass.",0
The observations suggest that testicular swelling and pain are side effects of desipramine.,1
Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.,1
METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.,1
Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence.,1
Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.,1
"According to the Naranjo probability scale, this reaction was probable.",0
"At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.",1
"A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.",1
"Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.",1
Perhexiline maleate is an agent currently under investigation in Canada that is used for angina unresponsive to other treatment.,0
In some cases this seems to happen because spironolactone causes diarrhoea.,1
We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.,1
"The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.",1
Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.,1
Corticosteroids should be used in low doses and with great caution in scleroderma patients.,0
Occurrence of IDDM during interferon therapy for chronic viral hepatitis.,1
Remission was confirmed objectively with pure-tone audiometry.,0
The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.,1
Right subhepatic abscess after cesarean section.,0
"In two cases of chronic schizophrenia complicated by diabetes mellitus, the concomitant use of the neuroleptica and oral antidiabetics was attended by the appearance of symptoms simulative of syndrome malin, i.e. hyperpyrexia, tachycardia, blood pressure instability, disturbances of consciousness, muscle rigidity, tremor, dysphagia, salivation and urinary incontinence.",0
Syndrome of inappropriate secretion of antidiuretic hormone associated with limbic encephalitis in a patient with drug-induced hypersensitivity syndrome.,0
CASES REPORT: Three eyes of three patients with mCNV were examined with fluorescein angiography (FA) and ICGA using Heidelberg Retinal Angiograph 2 and the conventional fundus camera before and after IVB.,0
Investigation of the cause of death in a gene-therapy trial.,0
Intracameral injection of tPA seems to be a safe and effective method for the treatment of unresolved total hyphema.,0
OBJECTIVE: To describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil.,1
"An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.",1
"Our analysis reveals that this method is useful, but also highlights potential areas for its improvement.",0
"The twelve-lead ECG exhibited a coved type ST-segment elevation in leads V(1) and V(2), and their enhancement was induced by pilsicainide.",0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
Further investigation into the utility and safety of dual therapy with an ACE inhibitor plus an ARB in pediatric patients is warranted.,0
A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.,1
Acute syphilitic meningitis in a patient with systemic lupus erythematosus.,0
"The role of antiemetics is invaluable in allowing cancer patients to complete, otherwise possibly intolerable, chemotherapy.",0
Nutritional support via enteral feeding tubes may interfere with the response to medications by a number of mechanisms.,0
Isoniazid-induced anaphylaxis.,1
Acute pancreatitis after long-term 5-aminosalicylic acid therapy.,1
"A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.",1
Infracardiac total anomalous pulmonary venous connexion and unilateral renal agenesis with ipsilateral phocomelia and unicornuate uterus were associated anomalies.,0
"Implicated triggering factors are numerous and include toxins, medications, and infectious agents.",0
"Reflex sympathetic dystrophy syndrome (RSDS), which probably has a multifactorial etiology, may appear after kidney transplantation.",0
"After rapid correction of severe hyponatremia, a 36-year-old man developed osmotic demyelination syndrome (ODS), manifested neurologically by impaired cognition, extremity weakness, bilateral third cranial nerve palsies, and gaze-evoked upbeat and rotary nystagmus.",0
Early recognition and aggressive treatment are necessary for patient survival.,0
"In both cases, the timing and dose of disulfiram was known.",0
"In contrast, eosinophil infiltration was rare in polyps obtained immediately after steroid treatment.",0
"The patient presented unfavorable evolution with progressive worsening of respiratory function, hypotension, and renal failure.",0
CT scan revealed infarction in the territory of the right middle cerebral artery.,0
"Her left ovarian cyst was extirpated surgically, and the histological diagnosis was endometrial cyst.",0
High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer.,1
"During 6 weeks of monitoring, arrhythmia did not recur.",0
CASE REPORT: A 64-year-old female patient with metastasized esophageal carcinoma received simultaneous chemoradiotherapy of the upper mediastinum with 50.4 Gy and cisplatin/5-fluorouracil.,0
We report the case of a young healthy woman who presented an early overanticoagulation when receiving acenocoumarol for a first thromboembolic episode.,1
"CONCLUSION: In conclusion, because of increased lymphoid malignancy risk, ovarian masses in JRA patients should be carefully evaluated.",0
"Bone marrow examination showed a generalized hypocellular picture, suggestive of drug-induced bone marrow suppression.",0
"A life-long antiretroviral treatment of congenital HIV disease, associated with a mixed fat redistribution syndrome and osteopenia already occurred during pre-pubertal age.",0
Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.,1
"The standard of care for treating schizophrenia is to first use monotherapy of adequate dosage and duration, including a trial of clozapine before adding a second agent.",0
"Hyperthermic isolated limb perfusion (ILP) (2 mg, TNF-alpha and 100mg, melphalan) was performed for an irresectable right thigh desmoid tumor with calf extension in a 49-year-old man.",0
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.,1
The patient was successfully treated with early surgery and combination antifungal therapy.,0
Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.,1
Colchicine-induced myopathy in renal failure.,1
This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.,1
"Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.",1
We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.,1
The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen.,1
Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.,1
The fluorine contained in niflumic acid induced a marked densification of trabecular bone in all 3 cases.,1
Severe cardiomyopathy following treatment with the tumour necrosis factor-alpha inhibitor adalimumab for Crohn's disease.,1
"In that case, as well as the one reported here, hepatitis symptoms occurred after completion of long-term treatment in patients who were asymptomatic both before and during therapy.",0
They were treated with cyclophosphamide for 98 and 44 months respectively.,0
CONCLUSION: The administration of tissue plasminogen activator was responsible for the large extent of hemorrhage and should be considered in the differential diagnosis of hemorrhagic choroidal detachment.,1
Few studies have addressed the impact of the new neuraminidase inhibitors in the prognosis of influenza after BMT.,0
Severe complications following thrombolytic therapy of an acute thrombosis of a prosthetic mitral valve.,0
Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.,1
Small-bowel obstruction during enzymatic treatment of gastric bezoar.,0
Multifocal osteonecrosis following chemotherapy and short-term corticosteroid therapy in a patient with small-cell bronchogenic carcinoma.,0
"We believe this represents the most delayed reported thrombosis post-sirolimus-eluting stent implantation, which might not have been preventable using even the latest FDA recommendations.",0
Three of the patients experienced myalgia and muscle cramps.,0
PURPOSE: The differentiating characteristics in blebitis and early and late endophthalmitis after glaucoma filtration surgery are reviewed.,0
Endoscopic retrograde cholangiopancreatography demonstrated normal biliary tree and pancreatic ducts.,0
The renal consequences of indinavir-associated nephrotoxicity are uncertain.,1
We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.,1
"We report on 7 patients (2 women, 5 men) with chronic renal failure, who developed under a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day) fatal neuromyeloencephalopathy.",1
"CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.",1
"Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.",1
Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.,1
"Although many cases are reported to recover with colony-stimulating factors and corticosteroids, others are unresponsive or partially responsive.",0
The rationale of suggesting N-AC and IVIG for the treatment of this syndrome relies on the theoretical synergistic effects of the two agents.,0
She was found to have PTLD of the nasopharynx.,0
The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.,1
"Long-term clinical experience with many of these agents has revealed nonglycemic effects on lipid levels, inflammation, and cardiovascular function.",0
The patient then received combined cataract and glaucoma surgery.,0
"Awareness of this condition is important, because early recognition can prevent morbidity and lead to safe and effective treatment.",0
Donepezil for behavioural disorders associated with Lewy bodies: a case series.,0
"Bronchoscopy guided transbronchial lung biopsy revealed interstitial thickening and type II pneumocyte activation, compatible with interstitial pneumonitis.",0
Angioedema and dysphagia caused by contact allergy to inhaled budesonide.,1
"First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.",1
"Administration of excessive insulin induced hypoglycemia within 4 to 8 hours, followed by rebound hyperglycemia.",1
"We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.",1
Doctors should be aware of the possible ocular side effects of methylphenidate.,0
Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.,1
The authors suggest that these pharmacologic agents should be used cautiously in treating patients with possible movement disorders (tics) and conclude that their findings lend support to the catecholamine hypothesis of the etiology of Gilles de la Tourette's disease.,0
These case reports provide evidence that 5-aminosalicylic acid may induce acute pancreatitis after long term treatment.,1
A patient with a 30% scald burn was treated with topical silver sulfadiazine (Silvadene).,0
"We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.",1
The topographic distribution of these changes was typical of WE.,0
Minimal change nephrotic syndrome after allogenic hematopoietic stem cell transplantation.,0
Intracavernous self-injection with vasoactive drugs is a new treatment for impotence.,0
"Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.",1
"The lesion was successfully resected using cardiopulmonary bypass, and the diagnosis of metastatic osteogenic sarcoma was confirmed.",0
For these reasons vasoconstrictor imidazoline containing solutions should be prescribed with caution and kept out of reach of children.,0
Herpes zoster ophthalmicus and syndrome of inappropriate antidiuretic hormone secretion.,0
"FSGS induced by Adriamycin (Pharmacia & Upjohn, Columbus, OH) has been observed experimentally in rats.",1
We present a case of cutaneous leucocytoclastic vasculitis in which amphotericin B might presumably be the aetiological factor.,1
Severe hyperphosphatemia associated with tumor lysis in a patient with T-cell leukemia.,0
"Sedation in the morning was identified as an important adverse event, which should be addressed by reducing the dose.",0
"RESULTS: A well-documented case report involving tap (draft) beer consumed while on an MAOI supports an earlier study, which recommended that all tap beers be restricted on MAOI diets.",0
The mechanism was proven by ribotyping of the microorganism and postmortem pathology.,0
"Three days after intravitreal injection of bevacizumab, acute ocular ischemic syndrome occurred.",1
We report a case of a child with neurodevelopmental delay with chronic constipation and a history of chronic mineral oil ingestion presenting as asymptomatic exogenous lipoid pneumonia (ELP).,1
A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.,1
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
Here we report on a patient with schizophrenia who suffered from medication-refractory coprophagia.,0
"Following CaEDTA therapy, continued recovery of conduction velocities, amplitude of compound muscle action potential, and diminution of conduction block at elbow were observed within a few months.",0
We report a case of cerebral arterial air embolism that was followed by a brain computed tomographic scan and magnetic resonance imaging during the first week after onset.,0
Initial clinical experience with centrifugal pumps coated with the Carmeda process.,0
"A computed tomography scan of the abdomen was helpful in elucidating the diagnosis, and surgical splenectomy resulted in a good patient outcome, though the period of hypotension had increased the extent of myocardial necrosis.",0
"The vasodilating action of calcium-channel blockers decreases the systemic pressure and in turn, may increase the pressure gradient and the left ventricular end-diastolic pressure.",0
Prosthetic joint infection is an infrequent but serious complication of total joint arthroplasty.,0
"A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.",1
The neurological symptoms resolved completely within 72 h.,0
Combining methylephedrine and Chinese herbal drugs might carry a risk of stroke.,1
A 57-year-old woman was scheduled to receive recombinant interferon-alpha retreatment for chronic active hepatitis C.,0
"We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.",1
In all three patients the bleeding stopped after a course of aminocaproic acid was begun.,0
"Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.",1
Twenty-three patients who experienced HCMV antigenaemia or DNAemia during or at the end of prophylaxis were included.,0
Avascular necrosis of bone is a recognised complication of glucocorticoid treatment--the risk of this increasing with higher doses and longer duration of use.,0
"After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.",1
"Therefore we recommend close follow up for patients that are switched from stavudine to zidovudine and, in case lactate measurement is not possible, free programs should provide safer drugs such as abacavir and tenofovir for patients that develop hyperlactatemia.",0
"Once the diagnosis of acute cerebral infarction is confirmed, thrombolytic therapy should be administrated within the time window of 3 hours.",0
"The authors suggest that fluoxetine-induced akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission and that the pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced ""jitteriness"" may be identical.",1
The patient was given 14 mg of etomidate and 100 mg of succinylcholine intravenously.,0
This case suggests that chemotherapy with its attendant immunosuppression is a predisposing factor in the development of necrotizing fasciitis and warrants a high index of suspicion.,0
Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.,1
Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.,1
Adenosine is used as pharmacological treatment of the first choice for the termination of regular small complex tachycardia.,0
This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.,1
No evidence of myocardial infarction was detected.,0
Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.,1
Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure.,1
We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII.,1
Rosiglitazone was discontinued and the edema resolved.,0
"Two months after thymectomy she presented with progressive cognitive decline, asymmetric quadriparesis and ataxia.",0
A complete remission was achieved twice.,0
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
A disulfiram-like reaction was noticed each time.,0
Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.,1
"METHODS: Thirteen consecutive patients with unresectable multifocal HCC and resistance to TAE were treated with combination chemotherapy consisting of arterial chemoembolization with degradable starch microspheres (DSM) (150-4500 mg on Day 1), mitomycin-C (4-8 mg on Day 1), continuous arterial infusion of 5-fluorouracil (1250 mg/120 h), cisplatin (25-50 mg/120 h) and l-leucovorin (125 mg/120 h) for 10-19 weeks.",0
This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.,1
"Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.",1
"The patient tolerated amoxicillin and cefazolin, suggesting that the sensitizing portion was not the beta-lactam ring.",0
We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.,1
The treatment was given on an outpatient basis without requiring prolonged patient sedation or immobilization.,0
We report three cases of post-transplant lymphoproliferative disorder (PTLD) in the context of autologous stem cell transplantation (ASCT) for multiple myeloma (MM) and non-Hodgkin's lymphoma.,0
This case report describes a non-cigarette smoking elderly woman who developed bronchial anthracostenosis and mediastinal fibrosis after long-term exposure to wood smoke.,0
A patient presented with dilated cardiomyopathy after many years of overusing an adrenaline inhaler.,1
"PURPOSE: To describe transient structured visual hallucinations in a patient with vascular age-related macular degeneration (AMD), following an intravitreal Avastin-injection.",1
RESULTS: A total of 178 cases were identified.,0
Topiramate and metabolic acidosis: a case series and review of the literature.,0
The clinical picture and efficacy of mirtazapine will be discussed.,0
Our case illustrates the importance of continuing adequate opiate therapy perioperatively in the increasing number of opioid-dependent patients to prevent potentially life-threatening complications such as broken heart syndrome.,0
Both 6-MP and AZA are widely used and are known to cause hepatotoxicity in a proportion of patients.,1
"Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.",1
Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.,1
"During two courses of cytostatic drug administration peak and trough plasma levels of phenytoin, carbamazepine, and valproate sodium were measured.",0
This case emphasizes the importance ot considering neoplastic disease as a potential hazard associated with the use of immunosuppressive drugs.,0
"Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.",1
"One patient had a partial response ongoing at 17+ months on ipilimumab despite failure with four prior therapies, and the other two patients showed durable stable disease, both still ongoing at 17+ and 20+ months, respectively.",0
"Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.",1
This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.,1
"This initial coagulation response was followed by a second phase of hematological response (starting on days 15-20) characterized by leukocytosis, occurrence of myeloid progenitor cells in the peripheral blood, and a decrease in bone marrow blasts (<1% on days 28 and 36).",0
"Treatment with oral prednisolone resulted in some improvement in the cutaneous signs, particularly over the face, trunk and proximal limbs.",0
Abnormal metabolism of valproic acid in fatal hepatic failure.,0
"Three patients with niacin-induced visual symptoms had cystoid maculopathy without leakage on fluorescein angiography, and a fourth patient with no fundus abnormality experienced cessation of visual symptoms upon discontinuation of niacin.",1
The pathogenesis of chemotherapy-associated thrombotic microangiopathy (C-TMA) has not been established.,0
Bone scan showed multiple areas of increased uptake consistent with osteomalacia and microfractures.,0
"With drug rechallenge two days later, ventricular tachycardia recurred within minutes.",0
Rhodococcus equi has emerged as an opportunistic pathogen usually causing necrotizing pneumonia in immunosuppressed patients but has been found increasingly in extrapulmonary sites.,0
Lithium toxicity in a neonate.,0
CONCLUSION: Severe and sustained ocular hypertension may occur after intravitreal ranibizumab.,1
"After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.",1
The expanded allele segregated with neurological signs in one kindred.,0
"A mechanism of unopposed alpha stimulation as a result of beta-2 receptor blockade is proposed, and a cautious approach to the use of propranolol in these patients is suggested.",0
"Significant dose reduction was possible in all three without loss of asthma control, emphasising the importance of back-titration to minimise dose.",0
Pravastatin is associated with myotonia in animals.,1
"Two unsuccessful attempts were made to repair the valve which was finally replaced, requiring cardiopulmonary bypass of 317 min.",0
Interferon alfa acts by stimulating the T-helper (Th) 1 immune response.,0
We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.,1
"Another four patients went into partial remission, amounting to an overall response rate of 58%.",0
"It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called ""3-week sulphasalazine syndrome"", a rare, but often fatal, immunoallergic reaction to sulphasalazine.",1
"This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.",1
A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).,1
CASE HISTORY: A 6-year-old white boy with a history of developmental delay was found to have an infiltrate in his right upper lobe on a chest radiograph obtained during evaluation for thoracic scoliosis.,0
"We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.",1
"To our knowledge, petit mal status lasting longer than 2-3 days has been documented only once [1].",0
We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.,1
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
"A 41-year-old woman was treated according to a diagnosis of depression, which was her 6th episode.",0
"Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.",1
"The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.",1
"Leflunomide, an immunosuppressive drug used in rheumatoid arthritis and in rejection in solid-organ transplantation, has been reported to have novel anti-CMV activity.",0
We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.,1
Lately these episodes were followed by brief spell of unconsciousness.,0
Hypercalcemia in a renal transplant recipient suffering with Pneumocystis carinii pneumonia.,0
Furosemide-associated fever.,1
"The criteria proposed by Earnest et al. should be implemented for each seizure case that requires a decision on the urgent need for therapeutic anticonvulsant levels, whether by mechanical infusion, manual intravenous push, or oral loading.",0
Reversal of pathologic cardiac parameters after transition from clozapine to olanzapine treatment: a case report.,0
Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.,1
These effects can increase the likelihood of its aspiration and subsequent impaired clearance from the respiratory tract.,0
The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.,1
Bull's-eye maculopathy associated with quinacrine therapy for malaria.,1
Biological data mainly revealed hepatic failure and lactic acidosis.,0
"Gold-salt therapy may result in damage to proximal tubules that leak renal tubular antigens, which in turn complex with autoantibody and produce an autoimmune membranous nephropathy.",1
We report a case of IVC filter thrombosis with associated vena caval obstruction successfully treated with catheter-directed thrombolysis and adjunctive mechanical thrombectomy.,0
"It has been proposed that the elevated serum uric acid levels are linked to other risk factors, such as hypertension, dyslipidaemia and diabetes.",0
Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.,1
"First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.",1
Transthoracic echocardiography showed a mass in the LA.,0
This is the first report of a middle-aged man with multiple coronary lesions.,0
After treatment with steroids there was gradual clinical improvement and disappearance of infiltrates.,0
"A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.",1
It is important to consider possible cross-sensitivity of chemically related compounds even when they are administered by different routes.,0
Monocomponent porcine insulin was injected into each quadrant of the pit.,0
We describe a detailed case of fulminant hepatitis induced by nevirapine (Viramune) and treated by liver transplantation.,1
"Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.",1
"Subcutaneous IL-2 is safe and well tolerated, with a mortality rate <3%.",1
"METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.",1
Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).,1
The self-administered therapy resulted in a severe cell-mediated immunodeficiency (as expressed by a nadir CD4 lymphocyte count of 2 cells/muL).,0
The latent period of therapy-related MDS (t-MDS) from the time of diagnosis of ATL was approximately 35 months.,0
Severe lidocaine intoxication by cutaneous absorption.,0
Cardiopulmonary resuscitation was successful after 45 minutes.,0
This case also extends the clinical spectrum of cerebral sinus thrombosis to include recurrent transient ischemic attacks alternating with seizures.,0
Failure to thrive is also a frequent side effect of treatment.,0
"The rash seen in this patient, who was treated with cephalexin, may be similar to the rash seen with ampicillin treatment of patients with infectious mononucleosis.",1
SSTR2A was also expressed in lymphocytes that had infiltrated thyroid tissue in Hashimoto's thyroiditis.,0
A patient is described with polycythemia vera who was taking anticoagulants and developed a spontaneous retropharyngeal hemorrhage after a violent sneezing episode.,0
"This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.",1
"The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.",1
A symmetric elevation of diaphragms was shown on radiography and fluoroscopy.,0
"Since no satisfactory remission was achieved using a multi-drug chemotherapy protocol that included cyclophosphamide, vincristine, cytosine arabinoside, prednisolone, and subsequently supplemented by L-asparaginase, it was replaced by another protocol combining vincristine, L-asparaginase, prednisolone, cyclophosphamide and doxorubicin.",0
Aminoglycosides have been reported to cause tetany by inducing renal wasting of magnesium and secondary hypocalcemia.,0
"Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.",1
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"All patients had symptomatic hypocalcaemia, including a tonic-clonic seizure and tachyarrhythmia in one case.",0
"The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.",1
"Sudden death in an infant from methemoglobinemia after administration of ""sweet spirits of nitre"".",1
"Unpredictable and potentially life-threatening, immune thrombocytopenia can occur with any drug, at times even after long, uneventful use.",0
"We present three patients with paradoxical seizures; their serum phenytoin levels were 43.5 mcg/mL, 46.5 mcg/mL and 38.3 mcg/mL.",1
"He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy.",0
A retrospective study was conducted of 40 loperamide poisoning cases recorded at the Centre National d'Informations Toxicologiques Veterinaires.,1
Analysis of a phenotyped human liver bank revealed that the antibodies recognised a 52.5 kDa microsomal protein which exhibited marked heterogeneity in its expression and appeared to be regulated co-ordinately with human CYP2C8 and 3A3/4.,0
This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.,1
Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.,1
"We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.",1
"Of 877 patients with Crohn's disease, 484 (55. 1%) received corticosteroids during the course of the disease, 196 (22.4%) received at least one course of parenteral nutrition, and 125 (14.3%) received both corticosteroids and parenteral nutrition.",0
INTRODUCTION: Leflunomide is an immunomodulating agent with proven efficacy in rheumatoid arthritis.,0
The success rate of the two approaches appeared to be approximately equal.,0
He presented with blurred vision.,0
A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram.,1
Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.,1
"When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.",1
She passed a non-solid stone and continued indinavir treatment.,0
"A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.",1
RESULTS: A two-year-old boy was surgically treated for residual esotropia after two botulinum toxin A injections.,0
"She had also been submitted to radiotherapy for a subcutaneous plasmacytoma, detected some months before, at the same site of the cutaneous lesions.",0
"RESULTS: A complete response (CR) was obtained for all three patients, resulting in a response rate of 100%.",0
"Given the limited experience with this agent in treating behavioural disorders associated with DLB, further studies are warranted.",0
"This is an unusual association, and to date only seven cases have been reported.",0
A case of systemic lupus erythematosus complicated by pure red cell aplasia and idiopathic portal hypertension after thymectomy.,0
Hypocomplementemia and transient evidence of vasculitis suggested the presence of immunecomplexes.,0
"A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery.",1
The use of somatostatin analog in gastroenteropancreatic tumors other than carcinoid.,0
Early diagnosis of leukoencephalopathy of acute lymphocytic leukemia by MRI.,0
CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.,1
Drug-induced gingival hyperplasia is well documented within the literature.,0
"This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.",1
Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.,1
"Two years after HSCT, the patient developed nephrotic syndrome.",0
Cis-retinoic acid (RA) may further increase the risk of developing BMTN.,1
"A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.",1
Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction.,1
"We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.",1
We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.,1
"Neither the prior history of psychiatric illness nor brain damage predisposed to such response on treatment, and in most patients, it was not a part of hypomania or a more diffuse psychiatric disturbance.",0
"CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual ""shining,"" glare, color vision anomalies, and gradually decreased vision.",1
White clot syndrome and continuous arteriovenous haemofiltration.,0
Renal failure associated with acetazolamide therapy for glaucoma.,1
CONCLUSIONS: The observation that neurotoxicity developed with a delay of 24 to 48 hours after acyclovir peak serum concentrations could explain the wide range of acyclovir levels reported in similar cases.,1
CONCLUSIONS: These data demonstrate that rupture of the ventricular free wall can occur early after thrombolytic therapy and may have a subacute course.,0
She had taken no drug except for the IFN-beta-1b.,0
"In addition, IVIG may effectively modulate the overreactive immune system in AHS.",0
"DATA SOURCES: Published scientific papers, review articles, book chapters, and clinical experiences.",0
"With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.",1
Physicians should be cognizant of this potential complication in patients receiving thalidomide or thalidomide-like drugs who present with fever and pulmonary infiltrates and fail to improve despite treatment with broad-spectrum antibiotics.,1
Epithelioid angiosarcoma of the lung is a rare late complication of Lucite plombage treatment of pulmonary tuberculosis.,0
"Alopecia, nausea, and vomiting were attributed to the cyclophosphamide component of the therapy.",1
A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.,1
"We present two new cases, and we review 55 additional cases from the literature.",0
"We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.",1
A case of severe hyperlipidemia caused by long-term tube feedings.,0
"Bilateral percutaneous nephrostomy catheters were placed in the renal pelvises, and local irrigation with amphotericin B was performed for 3 weeks.",0
Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.,1
Antimonial derivatives induced a rapid remission.,0
"As the list of FMF-associated MEFV mutations is expanded, and/or new sequencing technologies permit more rapid screening, the value and interpretation of genetic testing for FMF will become more straightforward.",0
The parameters of oxygen metabolism in a patient with cyanide poisoning who was admitted in a coma with seizures was monitored.,0
"He had experienced subarachnoid hemorrhage (SAH) from a left vertebral dissecting aneurysm, and had subsequently received a ventriculoperitoneal shunt against post-SAH hydrocephalus.",0
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
"To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.",1
"Patients who developed this syndrome did not differ from other patients in baseline ratings on the Brief Psychiatric Rating Scale (BPRS) and the Scale for the Assessment of Negative Symptoms, except that patients who developed the syndrome had a significantly higher mean baseline rating on the BPRS anxiety subscale.",0
This syndrome has been previously reported following cisplatin-based chemotherapy.,0
"This pathology should be treated promptly and with specific therapy to avoid progression to a severe, massive PTE.",0
We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline.,1
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
"A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.",1
We present a severe case of TPP in a 22-year-old Latino male with rapidly progressive ascending paralysis and hypokalemia severe enough to lead to cardiac arrest.,0
"An 8-year-old girl, who had been vaccinated with BCG without subsequent regional reactions, developed osteomyelitis in the left calcaneus 7 months later.",1
"The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.",1
Rapid liver failure related to chronic C hepatitis in an HIV seropositive hemophilic patient with severe immunodepression.,0
Psycho-pharmacotherapy for anxiety and obsessive-compulsive disorder: the issue of prolonged barbiturate retention.,0
"Two weeks after stopping the adminsitration of tacrolimus, his urine output improved, and the hemoglobin and serum creatinine normalized.",0
"The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).",1
Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.,1
The pitfalls of potassium replacement in thyrotoxic periodic paralysis: a case report and review of the literature.,0
A preclinical study in rats treated with TKI showed a statistically significant increase in benign and malignant renal tumours.,0
"We feel that these results may be attributed to this specific growth factor combination, including ancestim, a cytokine known to act on primitive stem cells.",0
"While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.",1
A closer look at septic shock.,0
"Black cohosh is one of the most popular herbal therapies for premenstrual discomfort, hot flushes and other climacteric and menopausal symptoms.",0
Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.,1
"Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as ""red man syndrome"" and anaphylaxis.",1
Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.,1
"This report is of the successful treatment of a patient with multiply drug-resistant visceral leishmaniasis with a commercially prepared formulation of liposomal amphotericin B (L-AmB) ('AmBisome', Vestar, San Dimas, California, USA).",0
The effects on different biophysiological parameters and subjective impressions were studied in a patient with breast cancer who was not previously given any therapy before receiving Ukrain.,0
"Following steroid withdrawal and institution of gammaglobulin, the patient grew 6 inches within 2 years, regaining his vision, retrieving his stature, and normalizing his psychosocial development.",0
OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.,1
"Although the possibility of this interaction has been noted, no previously documented occurrence of this interaction has been identified.",0
We report the case of a 60-year-old woman who developed erythema and erosions in the axilla and groin while on PLD for breast cancer.,1
Noncardiogenic pulmonary edema during intrabiliary infusion of mono-octanoin.,1
"Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.",1
"Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.",1
We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.,1
After 3 weeks of CI a thrombus formation in the portal vein was detected by ultrasound and confirmed by duplex ultrasound.,0
"The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.",1
An oncological consultation recommended 4 mg nebulised morphine and 4 mg dexamethasone in saline as treatment for the bouts of breathlessness.,0
Detection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.,1
Linear immunoglobulin A bullous dermatosis induced by gemcitabine.,1
Trichosporonosis appears to be an emerging fungal infection among immunocompromised individuals (including both hematological and solid organ transplant recipients).,0
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
"Because sumatriptan can cause coronary artery vasospasm, patients with significant risk factors for coronary artery disease should be carefully evaluated for cardiovascular disease prior to the use of sumatriptan.",1
"The authors performed a literature search using PubMed and the search terms ""gemcitabine"" and ""radiation recall"" to find prior cases of radiation recall attributed to gemcitabine.",0
This report describes the case of fungal sinusitis in severely immunocompromised 32-year-old male with common-type acute lymphoblastic leukemia who relapsed after autologous peripheral blood transplantation.,0
OBJECTIVE: To describe the use of botulinum toxin injection of the lacrimal gland for palliative treatment of epiphora secondary to canalicular obstruction from docetaxel therapy.,0
"During intensive care, including steroid-pulse therapy, the patient developed rapidly progressive anemia caused by active bleeding from his small intestine, resulting in resection of 20 cm of ileum.",0
Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.,1
Thiazide-induced hyponatremia.,0
New criteria for the diagnosis of infective endocarditis.,0
"In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.",1
Adjuvant corticosteroid sparing therapy can also be associated with significant morbidity.,0
The other author believes tympanoplasty should be performed prior to reconstruction (Dr.,0
"The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.",1
"Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.",1
L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.,1
Pirmenol hydrochloride-induced QT prolongation and T wave inversion on electrocardiogram during treatment for symptomatic atrial fibrillation.,1
"When catheter disconnection, kink, or dislodgement is not visible on X-ray, radioisotopic control is a safe and reliable method for assessment.",0
CONCLUSIONS: The administration of prostaglandin E1 to neonates can cause gastric-outlet obstruction due to antral hyperplasia.,1
Zolpidem tissue concentrations in a multiple drug related death involving Ambien.,1
Neuroleptic drug induced downregulation of nigral dopaminergic neurons may help to explain the persistent parkinsonism found in many patients after withdrawal of medication.,0
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
"We also found a severe decrease in her serum total carnitine level of 22 micromol/l (normal range 45-91 micromol/l) before changing the diet, suggesting secondary carnitine deficiency.",0
"Bronchiolitis obliterans organizing pneumonia (BOOP) is a rare disease, which is histopathologically defined by the presence of granulation tissue in the bronchioles, alveolar ducts and alveoli leading to plugging of the bronchiolar and alveolar lumen.",0
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).,1
"All were females (age range: 43 to 73, mean = 61.7 years) and had taken quinine for leg cramps.",0
Development of tics in a thirteen-year-old male following atomoxetine use.,1
The patient developed pulmonary aspergillosis with a rapidly fatal outcome despite recovery from neutropenia and improvement of the underlying malignancy.,0
"Our experience of this case led us to conclude that: patients with pulmonary metastases may develop bilateral and/or recurrent pneumothoraces following chemotherapy; computed tomography scan is essential for defining the cause of SSP; and closed chest tube drainage remains the therapy of choice, while chemical pleurodesis may also be used to prevent recidivant SSP.",0
CONCLUSION: Topical thiotepa appeared to be an effective treatment for recurrent corneal haze following myopic PRK.,0
"From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).",1
"She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.",1
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
HNCPs with malignant disease require judicious dental treatment planning prior to radiation therapy (RT) and/or chemotherapy.,0
A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.,1
Enalaprilat induced acute parotitis.,1
One patient died with myeloid leukemia at 43.5 months after initial treatment.,0
Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.,1
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.,1
We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.,1
The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.,1
Sodium nitroprusside was stopped and amrinone 100 mg bolus followed by 10 micrograms.kg-1.min-1 was given in addition to adding PEEP to the ventilation.,0
The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.,0
"Infants are particularly susceptible to chronic nitrate-induced methemoglobinemia because of their low stomach acid production, large numbers of nitrite-reducing bacteria, and the relatively easy oxidation of fetal hemoglobin.",1
During the 12th week of treatment she showed transient thyrotoxicosis.,0
Tetany in a child with AIDS receiving intravenous tobramycin.,1
Gabapentin withdrawal presenting as status epilepticus.,1
"We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).",1
Lithium therapy was discontinued because of poor compliance to the medication and intolerable polyuria.,1
A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.,1
The patient's platelet count dropped rapidly to a level of 1000/mm3 after receiving a single 600 mg dose of rifampin.,0
"Recurrent, bilateral, and severe conjunctival hemorrhages mandate the search for an underlying etiology, such as a blood dyscrasia, blood clotting disorder, or recurrent increased intrathoracic pressure caused by repetitive vomiting or coughing spells.",0
This article presents a rare case of acute toxic hepatitis in thirty-one-year old primigravida.,0
Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.,1
To replace or not to replace? - Partial coning and a sixth nerve palsy secondary due to displacement of a tunnelled intrathecal catheter for pain control.,0
Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.,1
"Two days after completing this regimen, the patient developed a rash with blistering.",0
Any areas of obvious third-degree burns would be debrided and grafted.,0
"When it occurs, trichosporonosis usually is associated with hematological malignancies and, to the best of our knowledge, has not been previously reported in a liver transplant recipient.",0
"Five months later, he presented with watery diarrhea and abdominal distention.",0
In all cases SMS 201-995 treatment has been well tolerated and has few side-effects.,0
"After intravitreal injection of triamcinolone acetonide, cataract may rapidly develop in eyes that have been intensively treated, topically and systemically, by corticosteroids for several years.",1
"The CYP2D6 phenotype, determined when the patient received the antidepressant comedication, characterized a poor metabolizer status (dextromethorphan metabolic ratio >0.3), despite a heterozygous genotype containing a wild-type allele with extensive metabolic capacity and a mutant non-functional allele (CYP2D6*1A/CYP2D6*4A).",0
Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.,1
"Given that psychiatric symptoms are not included in the manufacturer's lists of adverse drug reactions, the incidence may be significantly higher.",0
"The side effects in all patients have included varying degrees of anorexia, fatigue, ipsilateral forehead dermatitis, blepharitis, and conjunctivitis.",0
The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.,1
The patient had no history of seizures in the past and no gross neurologic deficits.,0
"On further questioning, the patient admitted to the daily use of mineral oil for constipation.",0
Warfarin-associated bleeding complication saved life.,1
"The ulcers slowly healed with local therapy, but two patients required dose modification of the pegylated interferon alfa-2b and one patient required treatment withdrawal.",0
Myoclonus is a movement disorder of various etiologies.,0
Severe respiratory syncytial virus pulmonary infection in a patient treated with fludarabine for chronic lymphocytic leukemia.,1
"This report details the pulmonary pathologic findings in four patients with rheumatoid arthritis, who developed new onset of pulmonary signs and symptoms with alveolar infiltrates temporally related to the institution of etanercept therapy.",1
"Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat.",1
Glucocorticoids in early rheumatoid arthritis.,0
"There was rapid spontaneous and complete regression of the eruptions, which was probably an expression of transient lymphomatoid papulosis in connection with MF.",0
RESULTS: Extensive squamous metaplasia was found in endometrial glands following progestin therapy.,1
Local dense accumulations of skin debris that became crusty were also observed.,0
Report of two cases.,0
Cutaneous lichenoid eruptions can arise as a result of exogenous compound exposures.,0
A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.,1
RESULTS: Visual loss was mild and generally nonprogressive.,0
Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.,1
Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.,1
Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.,1
Simplifying psychotropic medication regimen into a single night dosage and reducing the dose for patients with chronic schizophrenia.,0
"OBJECTIVE: To report a case of ciprofloxacin-induced psychosis and to discuss occurrence rates, risk factors, possible etiologies, preventive measures, and treatment courses for this adverse reaction.",1
"As in our patient's case, curative treatment for LDE requires discontinuation of the drug.",0
"The neuropathologic findings in these cases, although similar, varied in severity and distribution.",0
"To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.",1
Environmental agents have long been thought to be linked to the development of malignancies.,0
It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.,1
"We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.",1
Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.,1
CONTEXT: Acute drug induced hepatitis has not been commonly associated with epidermal growth factor receptor (EGFR) inhibitors.,0
She had been treated before with other antipsychotic drugs.,0
"Our patient also did not completely respond to these medications, but was successfully treated with cyclosporine alone.",0
Methadone has two roles in human immunodeficiency viral infection: pain management and treatment of opioid abuse.,0
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
CONCLUSION: Significant ocular complications such as an irreversible decrease of visual acuity may develop in patients treated with pegylated interferon.,1
Other possible causes of hepatotoxicity were excluded.,0
Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy.,1
An unusual complication of chemotherapy: an abscess in the pterygopalatine fossa.,0
"A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.",1
"Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis, a patient developed acute renal failure.",1
Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.,1
Reduction of methylprednisolone dosage rather than insulin therapy resulted in better control of glycemia.,1
"This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.",1
"Catheterization revealed 90% midstenosis of the left anterior descending artery, which was successfully treated with percutaneous transluminal coronary angioplasty (PTCA) and stent placement.",0
"A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.",1
An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.,1
"Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.",1
A hemogram indicated an inflammatory leukogram and a regenerative anemia with spherocytosis and thrombocytosis.,0
Three children completely recovered; one patient relapsed and died.,0
Two patients developed acute cholangitis and 2 patients experienced skin phototoxicity.,0
"We believe the temporal association of the abnormal liver enzymes in this patient, in the absence of other offending agents, argues strongly in favor of 6-TG as a cause of liver enzyme abnormalities.",1
We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI).,1
"SUMMARY: A 29-year-old woman sought treatment from a pulmonologist for a dry, hacking, constant cough not relieved by fast-acting inhalers or narcotic cough medications that had lasted for three weeks.",0
We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment.,1
A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.,1
"We describe a patient who experienced chronic nausea and an episode of confusion while treated with a small, stable dose of oral morphine in the setting of mild renal insufficiency.",1
"The liver had zolpidem present at a concentration of 4.74 microg/g, and the gastric contents had a total of 172 mg zolpidem.",0
"We detected proteinuria, serum cholesterol of 269 mg/dl, AST of 50 U/L, ALT of 41 U/L, serum total protein of 3.4 g/dl, serum albumin of 1.2 g/dl, positive cryoglobulin, and urine protein of 9.84 g/day.",0
"After discontinuing the drug, his edema resolved.",0
"After bilateral implantation of an angle-supported anterior chamber intraocular lens (AC IOL) in an allergic patient, the haptic tips were exposed through the limbus in the left eye.",0
Celiac disease onset after pegylated interferon and ribavirin treatment of chronic hepatitis C.,1
"Finally, the patient had improvement in symptoms and oxygenation after withdrawing lenalidomide and recurrence of symptoms when the drug was restarted.",0
Portions of the UL97 and UL54 genes were amplified and compared to the AD169 wild-type strain.,0
We report on a patient with acromegaly who developed severe drug-induced hepatitis during combined treatment with the long-acting somatostatin-analog octreotide and the GH receptor antagonist pegvisomant.,1
Intravenous TMP/SMX failed to improve the lesion.,0
Monitoring of the prothrombin time for cephalosporins or the bleeding time for moxalactam is the most reliable way to prevent what may be rapid emergence of clinical bleeding in patients with renal failure.,0
Low-dose methotrexate was added to their treatment regimens and led to significant improvement or clearing with a favorable side-effect profile.,0
"We report three patients, all of whom had preexisting diabetic dyslipidemia, who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy.",1
"Since toxicity develops with a remarkable delay, early removal of the drug (by hemodialysis) could possibly prevent central nervous toxicity.",0
Clonally rearranged immunoglobulin heavy chain JH gene was not detected by Southern blot analysis.,0
The course of this case may be useful in the understanding of the pathogenesis of autoimmune hyperthyroidism.,0
"Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.",1
"PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.",1
We suggest that the duration of chemotherapy required to achieve a cure in patients with ovarian carcinoma in complete remission can be determined only by prospective controlled trials.,0
We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.,1
"Beginning ductopenia was present in two, suggesting that itraconazole might be responsible for the occurrence of prolonged drug-induced cholangiopathy.",1
The endometrium showed patterns of glandular cystic hyperplasia.,0
BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.,1
"Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.",1
"According to the Naranjo probability scale, the papular eruption was probably caused by methotrexate.",1
Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.,1
"Chylous ascites, a rare compliation following retroperitoneal lymph node dissection, has not been reported as a means of spread of testicular cancer.",0
The case is reported of eosinophilia-myalgia syndrome and polyneuropathy associated with myeloperoxidase specific antineutrophil cytoplasmic antibody.,0
"An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.",1
"In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.",1
The increased use of serotonergic agents (alone and in combination) across multiple medical disciplines presents the possibility that the prevalence and clinical significance of this condition will rise in the future.,0
Most cases of pancreatitis associated with L-asparaginase toxicity are self-limiting and respond favorably to nasogastric decompression and intravenous hyperalimentation.,1
"Our data suggest that low-molecular-weight heparin possesses strong renoprotective properties, thus confirming previous data from experimental nephropathies.",0
We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer.,1
Generalized pustular psoriasis precipitated by trazodone in the treatment of depression.,1
"CONCLUSIONS: Among the many presentations of ifosfamide neurotoxicity, clinicians should consider NCSE as a possible explanation for changes in consciousness in a patient receiving this agent.",1
"CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.",1
"Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or ""cutting"" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.",1
"However, brain metastasis was diagnosed.",0
Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.,1
Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.,1
"None of the patients treated with acyclovir had evidence of active varicella-zoster virus infection at post-mortem examination, but two had disseminated bacterial and fungal infections.",0
"As far as we know, this is the first report in English literature indicating such an adverse effect of pegylated interferon alpha.",0
Hypersensitivity to zonisamide was confirmed by the skin patch test.,1
Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.,1
"Patients receiving amifostine who develop only fever should be evaluated for an adverse drug reaction, as well as for sepsis and fevers of neutropenia, and it may be necessary to discontinue the drug.",1
We describe a possible drug interaction between these two drugs and recommend that they should only be used together with caution.,0
"The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.",1
"While excisional surgery remains the benchmark management for nonmelanoma skin cancer, topical imiquimod and C&C are important options for treating SBCCs.",0
"There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.",1
"Though proteinuria and nephrotic syndrome is a rare adverse effect of IFN-beta-1b therapy, physicians treating MS patients with this agent should pay careful attention to new clinical symptoms and laboratory findings.",1
"Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation.",1
Similar peripheral nerve histology was seen in a parallel animal study in which the severity of the neuropathy was dose-related.,0
Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.,1
"Serious phenytoin hypersensitivity reactions may appear as dermatologic, lymphoid, or hepatic syndromes.",1
"Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or ""cutting"" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.",1
"Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.",1
"We report here a 34-year-old woman with complicated severe opportunistic pulmonary infection, who was treated with the newly developed antibiotics quinupristin/dalfopristin (QPR/DPR) and voriconazole.",0
The relationship between infliximab treatment and lymphoma in Crohn's disease.,1
"Thus, we suggest that a hypercoagulable status possibly created by both the malignancy and cisplatin-based chemotherapy may have played a significant role in the development of the aortic thrombus.",0
The patient then suffered from sudden left chest pain and dyspnea.,0
Close follow-up during the first month of life is warranted for infants exposed to diazepam prenatally.,0
The evidence from this series of cases and from six additional cases identified in the literature suggests that the risk of endometrial sarcomas may be increased by estrogen therapy or endogenous disorders that lead to unopposed estrogenic stimulation of the uterus.,0
"We present herein the case of a 56-year-old woman in whom bilateral and recurrent SSP was caused by the rupture of pulmonary lacunae induced by chemotherapy, given for bilateral lung metastases secondary to breast carcinoma.",0
Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.,1
This case showed a remarkable granulomatous reaction in association with tumor elimination.,0
Amiodarone was discontinued after discussion with the cardiologist.,0
Direct biopsy of this mass revealed a large B-cell lymphoma.,0
Adverse effect of verapamil in myasthenia gravis.,0
"On admission, he presented with clinical features of chronic GVHD including transient exacerbation of cholestatic liver injury.",0
This calls for adequate evaluation and monitoring of patients on this drug.,0
A 63-year-old woman with seropositive rheumatoid arthritis was successfully treated with auranofin for 12 months.,0
Valproate elimination was enhanced by the continuous infusion of activated charcoal.,0
Best-corrected visual acuity measurements were performed at every visit.,0
"This case demonstrates an occupational activity (construction) that has now become the dominant source of lead exposure for U.S. adults, the importance of a good occupational history to suspecting and making a diagnosis, the possible outcomes of chronic lead toxicity, and the importance of preventing further exposure and using proper methods to treat acute toxicity.",1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
SETTING: University hospital with a comprehensive in- and outpatient rehabilitation center.,0
"We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.",1
"Between 1989 and 1996, 4 cases of Pneumocystis carinii pneumonia (PCP) were observed in patients seronegative for the human immunodeficiency virus who were receiving corticosteroid therapy for dermatomyositis in our institution.",0
Reactivation of tuberculosis is a complication of its use.,0
"He had a permanent pacemaker inserted 4 years previously for Mobitz type II AV block detected on stress electrocardiogram, which developed 1 month after initiation of lopinavir/ritonavir.",0
Use of fenofibrate in the management of protease inhibitor-associated lipid abnormalities.,0
We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).,1
The catheter was removed and the abscess was drained.,0
Her serum transaminase and albumin levels were normal.,0
"On admission, serum calcium and albumin was 3.5 mg/dl and 3.7 g/dl respectively.",0
"We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.",1
"However, the treatment can be associated with significant morbidity.",0
A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea.,1
Renal biopsy examination showed typical features of MN in all patients.,0
"In the cornea, it has been shown in animal and in vitro studies to inhibit epithelium mitosis, fibroblast mitosis and migration, as well as to reduce collagen deposition.",0
Asthma and urticaria during disodium cromoglycate treatment.,1
Discontinuation of the itraconazole caused resolution of the drug eruption.,1
Heparin-induced thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement.,1
None of the patients had experienced visual hallucinations before this event.,0
"A survey of members of the Retina, Macula, and Vitreous societies and the National Registry of Drug-Induced Ocular Side Effects identified three additional cases.",0
Report of two cases and concise review of the literature.,0
"In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.",1
"The case of a 37-year-old obese man, who rapidly developed features of this syndrome after an antecedent pharyngitis and cellulitis, is presented.",0
"We observed an unexpectedly rapid rise in platelet counts with complete haematological recovery after a BEAM regimen, in a patient who could not be rescued by autologous transplant but who received filgrastim, epoetin alfa, and ancestim.",0
The kidney function returned to normal within 1 week.,0
Examination revealed a combined restrictive and obstructive defect in pulmonary mechanics and severe compromise of gas transfer across the pulmonary alveolar-capillary membrane.,0
"CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.",1
"Moderate lymphocytic infiltration of the substantia propria of the conjunctiva of both upper and lower lid specimens was present, as was scarring and keratinization of the epithelium.",0
Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.,1
An anesthesia provider must immediately initiate treatment if bronchospasm is suspected in order to avoid negative sequelae.,0
A repeated low dose of the drug induced hyperkalaemia.,0
A potential role for renal and hepatic impairment in the observed protracted course of amiodarone-induced thyrotoxicosis is suggested.,1
"Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.",1
Renal tubular acidosis was complicated by probable nephrogenic diabetes insipidus and acute renal failure.,0
Treatment of lithium-induced diabetes insipidus with amiloride.,1
Lamotrigine toxicity secondary to sertraline.,1
"A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.",1
Chronic irritation of the gastric antral mucosa led to ulceration and formation of hyperplastic polyps.,0
These patients require not only treatment of their acute medical problems but also specialized multidisciplinary acute rehabilitation starting as early as possible during their hospital stay.,0
We examined the effect of total parathyroidectomy (PTX) on renal anemia in 20 dialysis patients with secondary hyperparathyroidism.,0
Pulmonary fibrosis associated with nabumetone.,1
"Though the voluntary recall was in effect, the family already had a bottle of the medication at home.",0
Toxic effects were less severe than previously described: this may be attributable to relatively low doses of DCF or to precautions taken to prevent tumour lysis syndrome.,0
It may be concluded that rhEPO is possibly effective in a subgroup of MDS patients where the disease is less advanced.,0
"The management of genitourinary malacoplakia in renal transplant recipients has been unsatisfactory previously, as evidenced by an unacceptably high rate of graft loss and mortality.",0
Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy.,1
Asthmatic patients receiving antileukotrienes may develop hypereosinophilia as a part of a Churg-Strauss syndrome.,0
"A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.",1
Pulmonary toxicity secondary to procarbazine.,1
"However, this mechanism may fail under certain circumstances, in particular if D2 dopamine antagonism exceeds a certain threshold.",0
A 53 year old Greenlandic male was admitted twice over a period of 4 years with a new complete right bundle branch block after ingestion of 10 g and 4 g of carbamazepine respectively.,1
The Patient conceived 2 years after completing therapy and gave birth at term to a normal infant.,0
A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.,1
"A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.",1
"We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.",1
"Treatment with diazepam led to resolution of symptoms within 6 hours, and there was no recurrence at 6 weeks' follow-up.",0
RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.,1
"RESULTS: In these four patients, the use of caspofungin as an additional drug to the standard trimethoprim-sulfamethoxazole regimen led to a rapid improvement and a complete cure of pneumonia.",0
"Furosemide, spironolactone, allopurinol, and hydroxyurea were considered possible causes of the reaction and were discontinued.",0
OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.,1
Carbamazepine is an anticonvulsant most effective in treating complex partial and generalized tonic-clonic seizures.,0
The association between heparin and priapism is often recognized; abnormal platelet aggregation could play a role in the pathogenesis of this side effect.,1
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
"A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.",1
The patient developed grade 3 capecitabine-induced headache.,1
Large cerebral infarction during praziquantel therapy in neurocysticercosis.,1
A 33-year-old male presented with brown discolouration of the fingernails following the application of 4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months.,1
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
Corticosteroids and azathioprine are considered standard treatment for autoimmune hepatitis.,0
The patient remained hospitalized for 3 months.,0
Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.,1
Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event.,1
Neither dosage nor serum levels of CBZ were in a higher range.,0
We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.,1
The neurotoxicity seen with HDARAC is dose-related and has occurred in up to 60 percent of treated patients.,1
"Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.",1
"These cases illustrate that the assumption that this drugs is without significant adverse effects may be unwarranted, especially for children and adolescents with chronic diseases.",0
These malignancies may represent either a new clonal disorder or a complication of drug treatment.,0
Ichthyosiform erythrodermas and the 'half-baby syndrome' treated with an aromatic retinoid.,0
Chryseobacterium indologenes was isolated from the blood cultures of an oncological patient with a totally implantable device.,0
CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.,1
"A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.",1
Additional application of FAB (2 x 80 mg) resulted in the immediate disappearance of arrhythmia.,0
Insulin-dependent diabetes mellitus associated with danazol.,1
Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.,1
Serious infection during neutropenia was the most common complication.,0
"Four years after the beginning of IFN therapy, he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody, and then 28 units/day of insulin injection was started.",1
It is important for clinicians to recognize beta-lactam-induced leukopenia and maybe recommend use of a drug from a different antibiotic class if continued treatment is indicated.,0
One such case that was managed conservatively with success is reported.,0
"It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.",1
General anesthesia was induced.,0
We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.,1
Interaction between antiepileptic and antiretroviral agents is an emergent problem caused by the increasing association of the two therapies.,0
Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C.,1
Heparin was replaced by argatroban on the 13th day.,0
"Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.",1
Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.,1
Only one case of a generalized maculopapular rash with enoxaparin has been reported in Europe.,1
Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described.,1
"During the management of intracranial hemorrhage, hyperkalemia developed.",0
PATIENTS AND METHODS: Progressive renal dysfunction developed in two adolescent black girls with high-risk ALL who underwent renal biopsies that were consistent with FSGS.,0
Topical anesthesia-induced keratopathy after laser-assisted subepithelial keratectomy.,0
Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.,1
It can also be used to treat hematuria through its action on decreasing urinary fibrinolysis.,0
A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy.,1
Near fatal acute colchicine intoxication in a child.,1
"This occurred consecutively after the administration of chemotherapy, during the ensuing period of myelosuppression.",0
He was asymptomatic at presentation and physical examination was unremarkable.,0
Pulmonary manifestations of interferon (IFN) use are a rare but well known complication seen with both standard and pegylated interferon alpha-2b (pegIFNalpha-2b) forms of the agent.,0
"Several cases of lithium-induced Creutzfeldt-Jakob syndrome have been reported to date; all of them were elderly patients and a half had ""therapeutic"" lithium serum levels.",1
Periodic alternating nystagmus in phenytoin intoxication.,0
We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.,1
"In the 36th week of gestation, the patient was introduced nitrofurantoin 100 mg a day due to symptoms of dysuria and enterococcus isolated from urine culture.",0
Both patients responded to intravenous administration of diazepam 10 mg and were given levetiracetam as maintenance therapy.,0
Pure red cell aplasia (PRCA) due to parvovirus B19 (PVB19) infection after solid organ transplantation has been rarely reported and most of the cases were renal transplant recipients.,0
The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.,1
Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.,1
"Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.",1
A review of four previously reported cases revealed that treatment with systemic glucocorticoid and CsA was effective for the DM and PnM.,0
"METHODS: Exploratory surgery was performed to remove the mass, and histologic and microbiologic studies were conducted.",0
Sotalol-induced bradycardia reversed by glucagon.,1
Hepatotoxicity from green tea: a review of the literature and two unpublished cases.,0
"The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.",1
"Clinical, laboratory (absence of others markers of hepatic disease), and histological findings seem to rule out common causes of hepatic disease.",0
"Since its release in the United States market in 1996, few cases of fatal acute intoxication have been reported in the literature.",0
Cholelithiasis in turn enhances the effects of cyclosporin on increased platelet aggregation.,0
He underwent five sessions of plasmapheresis.,0
Animal studies suggest that incontinence secondary to serotonergic antidepressants could be mediated by the 5HT4 receptors found on the bladder.,0
"This patient was using industrial strength glue to reattach a chipped tooth for approximately 1 year, and such use was associated with chronic exposure of his oral mucosa to this glue.",0
Transtubular potassium gradient (TTKG) also decreased and an inverse correlation was found between TTKG and doses of phosphate (r = -0.37; p < 0.02; N = 38).,1
Immunoprecipitation and Western blot analysis were then used to demonstrate that the aberrant DPD mRNA is translated into a nonfunctional DPD protein that is ubiquitinated.,0
"We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.",1
"An aggressive dose escalation (0.15, 0.2, 0.25 mg/kg/hr for 6 hrs) was done over the next 5 days in an attempt to avoid open-heart surgery.",0
"Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.",1
"The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.",1
"Cutaneous necrosis as a result of interferon alfa is an infrequent complication with unknown pathogenesis, in which a cutaneous local immune-mediated inflammatory process might be involved.",1
Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.,1
We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).,1
Baseline measurements of anterior chamber depth and lens thickness were obtained.,0
"In both patients, no known etiologic factors, such as systemic lupus erythematosus, poststreptococcal glomerulonephritis, sickle cell anemia, or acquired immunodeficiency syndrome, were evident.",0
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
"We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.",1
Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.,1
"OBJECTIVE: To report a possible drug interaction between the combination of fluorouracil (5-FU), levamisole, and warfarin.",0
"BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.",1
These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.,1
"Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.",1
"The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.",1
"Finally, after 9 years of infection, the diagnosis of seropositive RA was made in this HLA-DR1 positive patient.",0
A study of the intra-cellular cytokines in blood lymphocytes showed a production of IL4 from CD4+ lymphocytes after stimulation by gelatine.,0
"However, complications due to renal tubular acidosis (RTA) have recently been reported.",0
"RESULTS: The average time of presentation was 9 days, with the average time to CDT being 9.5 days.",0
We report here the case of a 36-year-old man with pre-B cell acute lymphoblastic leukemia.,0
An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported.,1
"We report the clinical course of a patient with bitemporal epilepsy who ingested 12 g of lacosamide, 56 g of gabapentin, 2g of topiramate, and 2.8 g of zonisamide during a suicide attempt.",0
This clinical course suggests that the sensorimotor polyneuropathy may have been caused by 5-ASA.,1
The tumor subsequently spread to involve skin of the forearm and arm.,0
Cutaneous lesions were pleomorphic but the typical picture of ecthyma gangrenosum was common in this group of patients.,0
"In uncontrolled digestive haemorrhage, a short course of somatostatin therapy can be of great help in controlling the acute bleeding and to avoid emergency laparotomy.",0
"Older therapies that have been widely accepted for a long time might not have had controlled trial data behind recommendations for their use, and once practice patterns become widespread, it is hard to change.",0
Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.,1
Myocardial infarction is rare in pregnancy.,0
This finding suggests that fluvoxamine can precipitate Schneiderian first-rank symptoms in some susceptible patients.,1
"Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir.",0
"A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.",1
The diffuse gastritis was aggressively treated with proton pump inhibitors.,0
Internists will need to be increasingly aware of and prepared for this pharmacologic complication.,0
"This is a report of a 9-year-old epileptic boy, who was studied over a period of 7 years.",0
"A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.",1
Improvement in the level of arterial blood gases and pulmonary diffusing capacity occurred after discontinuation of methotrexate therapy.,0
Aminophylline hypersensitivity apparently due to ethylenediamine.,1
INTERVENTION: A 50-year-old female with bilateral canalicular obstruction secondary to docetaxel therapy received botulinum toxin injections (5 units each) into the lacrimal glands of both eyes.,0
CONCLUSION: The administration of tissue plasminogen activator was responsible for the large extent of hemorrhage and should be considered in the differential diagnosis of hemorrhagic choroidal detachment.,1
"CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual ""shining,"" glare, color vision anomalies, and gradually decreased vision.",1
Myasthenia gravis is an autoimmune disorder where antibodies against the nicotinic Ach receptor resulting in impaired transmission at the NM junction.,0
AML/MDS occurred in 3/1374 CLL patients seen at a single institution between 1972 and 1992.,0
No adverse effects were observed.,0
"She received cyclophosphamide, phenylalanine mustard, urethane, and prednisolone intravenously or orally.",0
This is the earliest onset PCP in the literature after HSCT despite the prophylactic administration of TMP/SMX before transplant.,0
The ototoxicity of quinine can accurately be studied with ultrahigh frequency audiometry (up to 20 kHz).,1
We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.,1
"There are, however, well-known systemic side effects that may preclude continuation with these immunosuppressive therapies, and small trials of the anti-metabolite mycophenolate mofetil have been reported.",0
This report suggests that careful monitoring of patients undergoing oral amiodarone loading is necessary.,0
METHODS: We present the clinical and laboratory findings and describe the clinical course of our patient.,0
"Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch-test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.",1
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.,1
"Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: ""the retinoic acid syndrome"".",1
"CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.",1
Most current guidelines for the management of anaphylaxis list only epinephrine as a vasopressor to use in the event of cardiovascular collapse.,0
De novo absence status is a specific epileptic condition that should be suspected in all elderly subjects on chronic treatment with psychotropic drugs presenting in a confusional state.,0
"The presentation PTLD is diverse, including many patients with symptoms of the head and neck, which may make diagnosis difficult.",0
"Hemostasis was difficult to achieve, as the divided or disrupted amyloid-laden cortical vessels failed to vasoconstrict, their contractile elements replaced by amyloid beta protein.",0
This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.,1
Severe acidosis from acetazolamide in a diabetic patient.,1
Giant cell lichenoid dermatitis in a patient with baboon syndrome.,0
"We analyze a case of neutropenic enterocolitis which occurred in a patient with acute myeloid leukemia during chemotherapy and we suggest that, as well as intestinal wall thickness, hemodynamic worsening should be considered an indication for surgery.",0
Toxicity related to chloroquine treatment of resistant vivax malaria.,1
"We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.",1
"Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.",1
OBJECTIVE: To report a case of significant hepatic and renal failure with the use of argatroban in a patient with heparin-induced thrombocytopenia (HIT) requiring continuous veno-veno hemodialysis (CVVHD).,1
Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole.,1
The pulmonary toxicity is probably induced by piritrexim.,1
This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.,1
Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea.,1
"Her course, history and outcome are presented and the pharmacokinetics, the mechanism of action, signs and symptoms and treatment of strychnine poisoning are reviewed.",0
CASE SUMMARY: A 42-year-old African American woman with metastatic breast cancer developed progressive disease.,0
We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.,1
Patient B developed perioral and upper extremity paresthesias during the fourth cycle of CAP alone (2500 mg/m2).,1
Treatment of restenosis after bare-metal and drug-eluting stenting of an aorto-ostial lesion: challenges associated with excessive stent overhang.,0
"Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.",1
Administration of intravenous nitroglycerin in a patient with idiopathic pulmonary hypertension resulted in an increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance.,1
We conclude peripheral neuropathy with 5-FU is rare.,1
Potential role for topical clotrimazole in combination chemotherapy.,0
The neurologic toxicity can vary from being mild to severe and prolonged.,0
Immunofluorescent studies showed deposits of immunoglobulins and C3 in a granular pattern in the glomerular basement membranes.,0
"Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.",1
"Transvenous liver biopsy revealed hepatic angiosarcoma, a rare liver tumor classically associated with environmental toxins.",0
"The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.",1
Deep tendon reflexes (DTR) were absent in all extremities.,0
"Pilocarpine has been used as an ophthalmologic agent for decades; however, toxicity rarely has been reported in the medical literature.",0
"To our knowledge, this is the first report of significant hypotension associated with intravenous valproate in the treatment of status epilepticus in the pediatric population.",1
"Therefore, cidofovir was administered.",0
This observation illustrates that the pharmacological activation of the parathyroid CaR and other putative CaR on bone cells by calcimimetics did not protect against the occurrence of hypercalcemia of immobilization favored by a severe HPTH-II in a hemodialysis patient.,0
"In all cases the presentation was atypical, and in two cases the course was protracted, leading to some visual loss from corneal scarring and opacification.",0
Common peroneal nerve palsy following TNF-based isolated limb perfusion for irresectable extremity desmoid tumor.,0
Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.,1
We experienced 2 cases of mequitazine-induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems.,1
Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.,1
Cefoxitin therapy for Mycobacterium fortuitum bacteremia with associated granulomatous hepatitis.,1
At its peak the daily protein loss was 35.82 g.,0
Methemoglobinemia secondary to cleaning solution ingestion.,0
Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.,1
L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.,1
"The administration of ""sweet spirits of nitre"" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.",1
"Despite the dramatic response of Hodgkin's disease to intensive chemotherapy, the skin lesion was rapidly transformed into squamous cell carcinoma in 10 weeks.",0
"Finally, the patient entered complete hematological and cytogenetic remission, although the PML-RAR alpha fusion product was still detectable by PCR.",0
OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis.,1
Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.,1
CONCLUSIONS: Some patients may thus have a spuriously low cell count and may be unnecessarily denied effective treatment.,0
"Antiphospholipid syndrome is an autoimmune disease that is characterised by tendency to thrombosis, obstetrical and hematological complications.",0
Two cases of continuous ambulatory peritoneal dialysis-associated peritonitis due to Plesiomonas shigelloides.,0
"After the remission of the hypoalbuminemia and thrombocytopenia, the macular edema observed by OCT disappeared and visual acuity returned to normal.",0
Eosinophilic peritonitis responding to treatment with glycyrrhizin.,0
NEH must be considered in lupus patients receiving cytotoxic agents to avoid inappropriate use of corticosteroids or antibiotics in this self-limited condition.,0
Heightened seizure susceptibility associated with brain dermoid cyst and the administration of human chorionic gonadotropin (hCG).,0
MR findings in methotrexate-induced CNS abnormalities.,1
Administration of an angiotensin II receptor antagonist (ARB) during the second trimester of pregnancy is known to cause irreversible renal damage in the fetus.,0
Two cases are presented that illustrate a possible treatment role for ECT.,0
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.,1
"Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.",1
"At present, the child is growing on by GH replacement therapy.",0
Astute nursing care is essential to prevent complications associated with this procedure.,0
Endoscopic injection of sclerosing agents is a strategy for control of esophageal varix bleeding.,0
"With the progression of immunoreconstitution, the lesions healed spontaneously.",0
Nonconvulsive status epilepticus due to ifosfamide.,1
"The incidence, cause, and mechanism of such a side effect are unknown but should be considered in patients receiving high-dose carmustine infusions.",0
Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.,1
"The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.",1
Chemoradiation therapy: effect on dental development.,0
Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past.,1
Previous studies have noted the difficulty in performing accurate injections into this area.,0
We recommend strict monitoring of serum antiepileptic drug (AED) levels to avoid toxicity and inadequate seizure control.,0
One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.,1
"Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.",1
"Ten hours later, the patient developed myoclonus of his upper extremities and face.",0
These multiple overlapping factors probably lead to rhabdomyolysis in a minority of patients receiving vasopressin infusion.,1
Nitrofurantoin-induced acute liver damage in pregnancy.,1
Vitreous touch after phacoemulsification.,0
"Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.",1
"We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.",1
Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.,1
"Compared with anthracyclines and taxanes, the interval from the completion of radiation therapy to the initiation of chemotherapy is less for gemcitabine (median time of 56 days for gemcitabine, compared with 218 days for the taxanes and 646 days for doxorubicin).",0
She received chemotherapy according to the previously described modified St.,0
CASE REPORT: A 27-year-old male presented a corticosteroid-resistant nephrotic syndrome secondary to collapsing FGS corticosteroid.,0
"Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.",1
"In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.",1
We report a case of a 54-year-old female who ingested approximately 100 propoxyphene hydrochloride tablets in a suicide attempt.,0
"Pharamcokinetic parameters were found to be significantly different from published adult parameters, such as a faster elimination rate, shorter half-life, and increased clearance.",0
The aim of our paper was to describe hepatotoxicity of sirolimus (SRL) in a kidney graft recipient.,1
Unexplained menorrhagia and hematuria occurred in a 13-year-old female with a mild inherited platelet disorder who had never experienced prior bleeding as a result of this disorder.,0
"Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.",1
Well-known signs of methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration.,1
Lithium interferes with reserpine-induced dopamine depletion.,0
Anaphylactoid reactions with intraperitoneal cisplatin.,1
Massive subchorionic hematomas following thrombolytic therapy in pregnancy.,0
She had received this same dose in the past without incident.,0
"We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis.",1
"Recently, the patient has exhibited signs of tardive dyskinesia.",0
Three cases are described in which periorbital topical corticosteroids appear to have resulted in raised intraocular pressure or glaucoma.,0
"We speculated that SLE associated with systemic vasculitis and uremic milieu over a number of years may represent the perfect preexisting condition for calcific arteriolopathy to occur following which several factors including chronic administration of corticosteroids, photosensitivity in lupus, and significant weight loss may have contributed to acral gangrene and mesenteric ischemia.",0
"The former patient had complained once that his visual acuity had decreased after the termination of IFN therapy, and the latter patient complained twice during IFN therapy that his visual acuity had decreased.",1
A 68-year-old female patient with advanced ovarian carcinoma collapsed whilst receiving a carboplatin and cyclophosphamide infusion.,1
Acute colonic diverticular perforation presenting as left ear pain and facial swelling due to cervical subcutaneous emphysema in a patient administered corticosteroids.,0
We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.,1
"OBJECTIVE: To demonstrate the potential value of obtaining routine fungal cultures of donor rims at the time of corneal transplantation and instituting prophylactic therapy in culture-positive cases, even in the absence of clinical evidence of established microbial keratitis or endophthalmitis.",0
"Two of our patients developed TD after 23 months and 34 months of ziprasidone monotherapy, respectively.",1
Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.,1
"The third patient had dyspnea on exertion, unchanged over two months.",0
Posttransplant primary cutaneous Ki-1 (CD30)+/CD56+ anaplastic large cell lymphoma.,0
"Due to the more pronounced side effects of BCG compared to intravesical chemotherapy, reluctance still exists about BCG use.",0
We report a male patient with advanced AIDS who developed hypercalcemia 2 weeks after institution of rhGH therapy.,1
Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease.,1
This may be due to a change in the type of metabolites excreted.,0
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.,1
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.,1
A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.,1
"CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.",1
"In three patients, carbamazepine was withdrawn, whereupon the deposits disappeared in two and decreased in the third, who changed to another drug.",0
"Median performance status (SWOG) was 2 (1 to 3), and clinical presentations included nephrotic syndrome (n = 1), symptomatic cardiomyopathy (n = 1), gastrointestinal involvement with polyneuropathy (n = 2), and hepatomegaly (n = 1).",0
The patient died of heart failure complicated by pneumonia.,0
With this therapy the clinical manifestations of Reiter's Syndrome disappeared but sudden abdominal and bronchopulmonary symptoms complicated the picture and the patient died in a septical shock.,0
"We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.",1
"Patients with sustained and nonsustained ventricular tachycardia may present the clinician with difficult management problems in the assessment of risk, decision for long-term treatment, and selection of appropriate therapy.",0
"The use of outpatient dobutamine infusions by a small, portable infusion pump in 3 patients with intractable congestive heart failure (CHF) is described.",0
Ileal ulcers and cytomegalovirus infection in a case of Churg-Strauss syndrome.,0
Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.,1
"Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.",1
Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.,1
"Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.",1
METHODS: Three infants were treated with clobetasol propionate (Temovate) cream for vision-threatening eyelid hemangiomas.,0
A 27-year-old man presented with corneal ectasia in his left eye 4 years after myopic laser in situ keratomileusis (LASIK) and was treated with riboflavin-ultraviolet-A (crosslinking).,0
The causal relationship between hepatotoxicity and methylprednisolone treatment was deemed probable in both cases.,0
OBJECTIVE: This case report outlines a significant type of morbidity due to continued use of gabapentin during an episode of acute renal failure.,1
"Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.",1
A general physical examination revealed a boy with stable vital signs and without fever.,0
PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.,1
"Initially, she responded well to corticosteroids, but relapsed when medication was discontinued.",0
Rupture of the plantar fascia in athletes engaged in sports that require running and jumping has been reported.,0
"One week after beginning of HAART, tacrolimus was discontinued during 18 days due Ritonavir interaction.",0
"If a strong clinical likelihood of local disseminated intravascular coagulation exists, then In-111 platelets may be valuable in localizing the focus of platelet consumption.",0
CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.,1
BACKGROUND: A 39-year-old male with multiple myeloma was admitted for treatment with melphalan and autologous stem cell reinfusion.,0
"In this case, unlike those previously reported, hyponatremia recurred 5 months after switching from citalopram to mirtazapine, which is believed to be a safe antidepressant.",1
Hydroxyurea (HU) and sodium phenylbutyrate (SPB) have been shown to increase fetal hemoglobin (Hb F) levels in patients with thalassemia intermedia.,1
"Drug-drug interactions are an important concern, as they may increase drug toxicity and, in the case of anticoagulant therapies, increase the risk of hemorrhage.",0
"The current report demonstrates successful treatment, even in the setting of subsequent bone marrow transplantation and immunosuppression, using a combination of surgical resection and posaconazole therapy.",0
This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.,1
"CONCLUSIONS: In this study, the hemostatic agent rFVIIa was well-tolerated and behaved in a safe and efficacious manner in all infants treated for life-threatening bleeding and coagulation disorders.",0
"During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.",1
"CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.",1
"During application, the patient complained of burning sensation of vagina and vulva.",0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
Fixed drug eruption in hands caused by omeprazole.,1
"CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.",1
PURPOSE: To report our experience with late vitritis associated with keratoprosthesis (KPro).,0
Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.,1
Graft versus host-like illness in a child with phenobarbital hypersensitivity.,1
"A 17-year-old anuric female patient with end-stage renal failure received a massive overdose of vancomycin and was treated with high-flux hemodiafiltration, as described in this report.",0
A transverse spinal cord syndrome occurred due to a pathological fracture of C5 and C6 and operative decompression was necessary.,0
"There were also larger cells (immunoblastic shape) that displayed CD20 positively, some scattered plasma cells, and eosinophils.",0
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
Stenotrophomonas maltophilia bacteremia after living donor liver transplantation: Report of a case.,0
The severity of cutaneous and hematologic toxicity experienced by our patient has rarely been reported.,0
"However, at the same time, multiple cutaneous violaceous papular-nodular lesions appeared on his left forearm.",0
"ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.",1
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"The treatment of choice is liposomal amphotericin B, which failed in our patient.",0
CONCLUSION: This rare case of PTU-induced ANCA-associated vasculitis manifested with ototoxicity in combination with systemic involvement.,1
The use of botulinum toxin in the treatment of a parotid duct injury during Mohs surgery and review of management options.,0
Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.,1
"Total ischemic time was 3 h 34 min and 3 h 35 min, respectively.",0
"During treatment with alefacept, the patient's psoriasis improved markedly without exacerbation of his photosensitive SCLE lesions.",0
The exogenous origin of the lipid in the BAL fluid was confirmed by gas chromatography/mass spectrometry.,0
"We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).",1
"MATERIALS AND METHODS: In a retrospective analysis during a 5-year period, 112 patients underwent stent-graft placement for thoracic aortic aneurysms.",0
"The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).",1
This observation indicates the complex effect of HIV on joint inflammation.,0
A case of pyridoxine-dependent seizures is reported.,1
"After 14 days of therapy, he was taken to the emergency department with a 3-day history of fever, headache, and neck pain.",0
"To our knowledge, this is the first case of polymyositis associated with dilated cardiomyopathy after the administration of interferon in a patient with hepatitis B.",0
"Four occurred in combination with MTX, one with adalimumab.",0
"In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.",1
Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.,1
Amphojeloma: antacid impaction in a critically ill patient.,0
We present the course of illness of a 56 year-old patient with acute gastrointestinal bleeding after penetration of an aneurysm of the hepatic artery in the duodenal bulb.,0
"Standard pretransfusion testing was uncomplicated; however, after infusion, the serum was no longer compatible with the transfused units and a strong (4+) panreactive IgG antibody was detected.",0
Fourteen days after discontinuation of G-CSF therapy his monocyte counts returned to normal levels and a marrow aspirate showed a reduction in blast cells.,0
Transfusion-transmitted malaria in a kidney transplant recipient.,0
Fatal interstitial pneumonitis associated with docetaxel administration in a patient with hormone-refractory prostate cancer.,1
"Allergic side effects of AZA are rare, and reported allergic skin eruptions from AZA are very limited in Japan.",1
Complete resolution of the diarrhea occurred shortly thereafter.,0
"CONCLUSIONS: We describe a previously unreported complication of warfarin therapy in a patient over 75 years of age, to add to the cautions in prescribing this drug in patients of this age group.",0
Decrease of TTKG was possibly the result of suppressed K+ secretion.,0
The literature of vincristine optic nerve toxicity is reviewed.,1
"Although PWO is often easily managed with small doses of thrombolytic therapy (e.g., urokinase), it could result in a more serious complication, such as chemotherapy extravasation.",0
CONCLUSIONS: Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.,1
"No published reports of priapism with antidepressants were located, but 11 cases have been reported to the manufacturers.",0
A patient with recurrent fungal endocarditis on prosthetic mitral valve is presented.,0
"As the use of this drug for off-label indications and in pediatric populations increases, it is important for clinicians to better understand the drug's pharmacokinetic profile in these patient populations.",0
High-resolution CT (HRCT) findings of this disease were compared with the pathology.,0
All three patients had been taking an atypical antipsychotic.,0
"While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.",1
Heparin-dependent antibodies and thrombosis without heparin-induced thrombocytopenia.,1
"Therefore, data from large randomised, multicentre studies are needed to definitely answer the question of the relationship between safety and efficacy of this promising treatment option.",0
Trimethoprim-sulfamethoxazole-induced aseptic meningitis.,1
These symptoms recurred following 2 subsequent administrations of metoclopramide.,0
Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.,1
Carbamazepine induced right bundle branch block in a Greenlandic patient.,1
Terlipressin-induced ventricular arrhythmia.,1
Catheter occlusion by calcium carbonate during simultaneous infusion of 5-FU and calcium folinate.,0
Asthenozoospermia: possible association with long-term exposure to an anti-epileptic drug of carbamazepine.,1
CONCLUSION: We have introduced a case of anaphylaxis by calcitonin that suggest an IgE mediated hypersensitivity reaction.,1
"Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.",1
Pediatricians rarely use a systematic approach to establish the cause of drug reactions in the clinical setting.,0
"The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.",1
Toxicity is usually limited to anticholinergic symptoms.,0
Long-term follow-up after neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma.,1
Studies of porphyrin metabolism in patients treated with cyclophosphamide may help to elucidate this possibility.,0
"Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.",1
Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.,1
We report a case of biopsy proven myositis whose symptoms began within 10 days of receiving leuprolide acetate therapy for prostate cancer.,1
Panic attacks occurred for the first time in a patient suffering from delusional depression during treatment with a combination of an antidepressant and a neuroleptic.,0
The patient underwent a successive surgical procedure without any adverse event.,0
"The patient presented with severe bladder pain, fever, and eosinophilia several hours after instillation.",0
We report a case of MALA in which acute renal failure resulting from dehydration secondary to diarrhea and poor oral intake likely caused MALA.,0
"We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.",1
Ganciclovir-resistant cytomegalovirus (CMV) infection is an emerging problem in transplant recipients.,0
Total parenteral nutrition was continued without the fat emulsion and symptoms and signs disappeared.,0
The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.,1
Clinical signs of peripheral neuropathy developed 2 weeks and 12 months after the initiation of TNF-alpha antagonists.,0
Onset of male gynaecomastia in a patient treated with sunitinib for metastatic renal cell carcinoma.,1
Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.,1
We report two cases of Methicillin-resistant Staphylococcus aureus (MRSA) prosthetic hip infections successfully treated with a long course of linezolid.,0
Epoprostenol may be associated rarely with severe erythroderma.,1
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.,1
METHODS: Patients successfully treated with maintenance doses of im gold (< 20 mg/mo and not more than 10 mg/dose) were identified by chart review.,0
"Recently, CD20-negative tumors have been described after Rituximab therapy.",1
This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.,1
"Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.",1
A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.,1
"Despite optimal response of the cutaneous lesions to treatment, the disease progressed and the patient died from infectious complications eight months after the appearance of the tumors.",0
Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.,1
A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.,1
It is characterized as a long-acting prostacyclin analog that can be delivered by intravenous or subcutaneous continuous infusions.,0
"In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.",1
"Many drugs, especially antibiotics, can produce this untoward effect.",0
"DISCUSSION: After exclusion of other causes, the onset of thrombocytopenia after administration of lansoprazole, the resolution of the adverse reaction after discontinuation of the drug, and the fact that no other medicines were introduced during this time frame lead us to believe that this was most likely an idiosyncratic thrombocytopenic response to lansoprazole.",1
"OBJECTIVE: To describe what is believed, as of November 4, 2003, to be the first case published in the literature of acute interstitial nephritis (AIN) due to pantoprazole.",1
RESULTS: Complete removal of the tumor was performed.,0
"In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.",1
"Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.",1
Macrolide antibiotics inhibit the metabolism of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) that may result in myopathy and rhabdomyolysis.,0
"Because of a hypersensitivity reaction, initial therapy with penicillin G and gentamicin was stopped and substituted with cefazolin.",1
Transplant recipients are at highest risk during the first 3 months posttransplant.,0
"Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.",1
RESULTS: Evidence of neurological improvement and rehabilitation potential after severe myelopathy due to intrathecal injection of doxorubicin.,1
Biomicroscopy revealed amiodarone corneal deposits.,1
Severe erythroderma as a complication of continuous epoprostenol therapy.,1
"To determine the clinical significance of this organism, we reviewed the records of all patients whose blood cultures were positive for E. avium who were seen at our institution from 1986 through 1991 and identified nine cases of bacteremia due to E. avium.",0
"The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.",1
"Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.",1
Six patients were identified.,0
Agranulocytosis induced by vancomycin in an ESRD patient on CAPD.,1
The patient was doing well at 6 months follow-up.,0
RESULTS: Confocal and specular microscopy confirmed permanent endothelial cell loss with morphologic alteration after intracorneal penetration of ushaar latex.,0
The observations suggest that testicular swelling and pain are side effects of desipramine.,1
"Some degree of biochemical improvement was also noted in the other cases in whom the blood lactate levels before treatment were 15, 17, and 31 mM.",0
This is a rare case of ARDS associated with lithium intoxication.,1
"Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.",1
The second patient developed both autoimmune thyroid disease and a refractory pre-patellar bursitis after 50 months of IFN-beta therapy.,1
"Therefore, appropriate management of these behaviors seems necessary.",0
"Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.",1
Patients at increased risk could be identified.,0
CONCLUSION: This case and the results of the analyses are in accordance with the described problems and results published earlier.,0
"Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.",1
METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.,1
Paraplegia following intrathecal cytosine arabinoside.,1
Dyspnea possibly associated with controlled-release morphine sulfate tablets.,1
Incorrect identification of the organism as Corynebacterium J-K led to a change of antimicrobial therapy and clinical deterioration.,0
Hematochezia subsided with conservative treatment after a discontinuance of Kalimate administration.,0
Acute coronary syndrome induced by capecitabine therapy.,1
"In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.",1
"An 8-year-old girl with pauciarticular disease, antinuclear antibody, and uncontrollable iridocyclitis underwent 16 plasma exchanges with 5% albumin solution as replacement; despite removal of antinuclear antibody, her eye disease and arthritis were not helped.",0
Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers.,1
This complication has not previously been described in association with vasopressin infusion into peripheral veins.,0
"The physiological complexities of deep-diving research are reviewed, as well as the neuropsychiatric symptoms of the high pressure nervous syndrome.",0
"We report a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis, in whom the withdrawal of cyclosporin A induced a generalised pustular exacerbation and a aggravation of the joint condition.",1
We report for the first time on a patient who had isolated aspergillosis of the small bowel after autologous stem cell transplantation.,0
"AIMS: To present a case of piloerection after replacing fluvoxamine maleate with milnacipran hydrochloride, and to analyse this effect based on receptor occupancy theory.",1
The possibility of a recrudescence of a persisting infection was rejected.,0
She died 10 days after treatment was begun.,0
Primary coronary artery dissection occurring 2 months post partum in a 33-year-old woman is described.,0
"The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.",1
Disulfiram encephalopathy as a cause of the catatonia syndrome.,1
"Eosinophilia has been encountered from 0.2 to 61.7% in clozapine-treated patients, mostly with a transient course and spontaneous remission.",1
"Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.",1
"Chest roentgenogram showed interstitial congestive failure, and an EKG demonstrated sinus bradycardia.",0
It is possible that 5-HT2 antagonism is essential for therapeutic benefit in this condition.,0
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
"We describe a woman with relapsed cutaneous follicular centre B-cell lymphoma and secondary lymph-node involvement treated with rituximab alone, which induced a complete remission.",0
"To our knowledge, t(4;11)(p12;q23) has been reported in two previous patients, and MLL and FRYL rearrangement was demonstrated in one of them.",0
The possibility of severe rhabdomyolysis should be considered in a patient with water intoxication due to massive ingestion of caffeine-containing beverages.,1
Disulfiram encephalopathy as a cause of the catatonia syndrome.,1
A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.,1
Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?,1
CASE SUMMARY: An AIDS patient experienced an exacerbation of cytomegalovirus retinitis and was treated with foscarnet.,0
This report describes iatrogenic left main thrombosis treated by operative thrombectomy and coronary artery bypass grafting.,0
We suggested that colchicine should be used with caution in the presence of renal failure especially when other drugs which affect the metabolism of colchicine are also prescribed.,0
"The subject is a 66-year old woman, with a negative medical history of atopy, food and drug allergy, with arterial hypertension on a course of beta-blockers and with bladder carcinoma requiring surgery.",0
An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.,1
Correction after vitamin K administration suggested an organophosphate-related effect on vitamin K-dependent factor VII activity.,0
"Since this amount of FAB was insufficient to bind all DGTX present in the serum, cardiac DGTX toxicity (total AV-block) persisted.",1
"Serum PRL values rose normally after TRH administration, and evaluation of other pituitary hormones was normal.",0
PURPOSE: To illustrate the multiple causes of hypoxemia to be considered following cardiopulmonary bypass and how therapy given to improve oxygen delivery may have contributed to a decrease in arterial oxygen saturation to life-threatening levels.,0
A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.,1
"Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.",1
RESULTS: Two patients were obese and developed extensive abdominal wall skin necrosis.,0
Unexplained menorrhagia and hematuria: a case report of Munchausen's syndrome by proxy.,0
"Presented here is the successful treatment of adenomyosis in a woman presenting with menorrhagia, dysmenorrhea, and an enlarging uterus, for whom conservative therapy initiated with mefenamic acid was unsatisfactory.",0
Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy.,1
"Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).",1
A partial empty sella was found on a computed tomography scan of the hypothalamic-pituitary region.,0
"Extensive osseous tophi, resorbed rapidly during therapy with this xanthine oxidase inhibitor and not replaced by new bone matrix, were responsible for the deformity.",0
"Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.",1
Stevens-Johnson syndrome (SJS) is a mucocutaneous disease that can be lethal.,0
"Retinal abnormalities, including retinal hemorrhage and ""cotton-wool"" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.",1
Meperidine-associated central nervous system (CNS) excitatory toxicities are believed to be caused by accumulation of the active metabolite normeperidine.,1
The patient experienced two episodes of angioedema within a 10-hour period.,0
"In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).",1
Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.,1
"Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.",1
This is the first report of evaluating the urinary 6beta-hydroxycortisol/cortisol ratio in a case of porphyria.,0
"The in vivo occurrence of such giant forms is rare, and when observed histologically may result in an erroneous diagnosis or a diagnosis of multiple mycotic organisms.",0
The case of a bipolar patient who developed thyrotoxicosis with severe exophthalmos while on lithium therapy is described.,1
This is the second report of lactic acidosis in a patient on stavudine and lamivudine.,1
Using an illustrative case this article examines the prognostic significance of gastrointestinal haemorrhage and the risk of stopping anti-platelet therapy.,0
"After admission, albumin-dominant proteinuria persisted despite the discontinuation of interferon therapy.",0
"A female patient with HER2 positive, metastatic breast cancer presented with pulmonary infiltrates, and a plural effusion dyspnoea after several months of trastuzumab treatment.",1
"In addition, the mother drew large volumes of blood from the patient under the pretense of following a physician's orders.",0
METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.,1
Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.,1
We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.,1
OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.,1
"With this in mind, the authors present the case of a 32-year-old chronically institutionalized schizophrenic who showed a remarkable improvement in both tardive dyskinesia and psychotic symptoms following an open trial of clozapine, 900 mg daily.",0
"Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.",1
"According to the Naranjo adverse drug reaction probability scale, cesium was the probable cause of the patient's arrhythmia.",0
"DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.",1
"Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.",1
The patient died of respiratory failure after 8 days of steroid infusion and erlotinib discontinuation.,0
"We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.",1
"The increased use of cytostatic drugs, which are sometimes used in combination chemotherapy, may result in new and unusual cutaneous side effects.",0
We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.,1
A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates.,1
We report five cases of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) that were probably associated with olanzapine.,1
"Although praziquantel administration may have been effective in killing the parasite in both patients, we are concerned about the production of marked inflammation as a result of treatment.",1
SUMMARY OF BACKGROUND DATA: Several different causes of postoperative neurologic deficit have been reported in the literature.,0
Both the psoriasis and the HCL cleared.,0
He has not had any further episodes of thrombocytopenia to date.,0
"This case is remarkable since 1) ECM developed after subcutaneous and not after intramuscular injection, 2) the injection was given by the patient himself, and 3) glatiramer acetate can induce skin necrosis as a side effect.",1
"Mineral oil, a hydrocarbon, may not elicit a normal protective cough reflex and may impair mucociliary transport.",1
"This case draws attention to the association of long-term ergot dopamine agonist therapy with pleuropulmonary fibrosis, which can develop as late as 11 years after the initiation of therapy.",0
"After ingesting 500 mg of the drug, she experience generalized maculopapular eruption and facial angioedema.",0
"Their diagnoses were: chemotaxis defect, cellular immunodeficiency, combined immunodeficiency and chronic granulomatous disease (CGD).",0
"On discontinuation of the drug, serum CK concentrations returned to normal within eight days.",0
"ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.",1
"The keywords utilized were prostaglandin analogs, prostaglandins, prostamide, glaucoma, ocular hypertension, intraocular pressure, side effects, adverse effects, bimatoprost, latanoprost, lumigan, and xalatan.",0
We conclude that cephalosporins of the first generation or ciprofloxacin may be good alternatives to penicillin G in the treatment of C. hominis infection in patients known to be hypersensitive to penicillin.,0
"Two other patients who did not receive prochlorperazine, developed retinal problems which later improved, one after only 15 g of desferrioxamine.",1
The spectrum of nitrofurantoin lung injury continues to widen.,1
Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.,1
"In addition, a partial recovery of the scotopic b-wave full-field ERG was noted 19 years after cessation of treatment.",0
"After the first oral dose of propranolol, syncope developed together with atrioventricular block.",1
"A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.",1
"When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.",1
"We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.",1
The mother also falsified the laboratory data to erase from her daughter's file a laboratory result documenting warfarin in the blood.,0
The potential for severe toxicity in the setting of pediatric overdose should be recognized.,0
CASE SUMMARY: A 39-year-old white Jewish schizophrenic man treated with olanzapine developed an elevated serum CK concentration with a peak concentration of 4000 IU/L (normal < 230).,1
One of the etiologic factors of this disorder is prolonged prostaglandin E1 (PGE1) therapy of neonates with congenital cyanotic heart diseases.,0
PURPOSE: Tandem scanning confocal microscopy was performed on two patients with Acanthamoeba keratitis to provide images detailing characteristic findings of the disease.,0
Both patients had atrial flutter with 2 to 1 atrioventricular block that evolved into 1 to 1 atrioventricular conduction.,0
Ultrasonography revealed hepatic hyperechogenicity.,0
It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.,1
OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.,1
It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.,1
We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.,1
METHODS: No reports describing alcohol neurolysis of the superior cluneal nerve exist in the relevant literature.,0
"They discuss this underrecognized complication of valproate use and the implications for treating elderly patients, in whom valproate use is increasing.",0
"When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.",1
Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.,1
Transplant physicians should be aware of this unusual pathogen and the potential for both persistent line-related sepsis and possible septic arthritis.,0
We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.,1
The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.,1
"Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).",1
"Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.",1
"His complete remission was maintained with a nitrosourea, nitrogen mustard and methotrexate for 3 years.",0
"We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.",1
This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.,1
Little is known about the behaviour of endogenous thrombopoietin (TPO) serum levels during rapid sequences of dose-intensified chemotherapy.,0
CONCLUSIONS: Intravenous followed by intra-arterial therapy is a promising approach to the treatment of severe acute ischemic stroke.,0
"BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.",1
BACKGROUND: Agenesis of the inferior vena cava (IVC) is an uncommon congenital vascular malformation.,0
An infant presented 10 days after removal of a high umbilical arterial catheter with total occlusion of the distal abdominal aorta.,0
"Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.",1
We found that positive biopsies are usual only if the duration of symptoms have been allowed to persist for more than 6 months.,0
Complications of tumour overkill when associated with high dose methotrexate therapy.,0
We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.,1
Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.,1
"After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.",1
"This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus.",1
The disease is suggested endoscopically by its typical appearance.,0
"This profile should trigger a ""red flag"" as to the possibility of phenobarbital behavioral side effects or exacerbation of preexisting maladaptive behaviors.",1
"The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.",1
Four of the six experienced renal failure requiring dialysis.,0
Erosion of psoriatic plaques: an early sign of methotrexate toxicity.,1
"However, in our experience, these patients are sometimes placed on angiotensin-converting enzyme (ACE) inhibitors in accordance with guidelines applying to the general hypertensive population.",0
This syndrome generally occurs after a few weeks of therapy and may occur after L-asparaginase therapy is completed.,0
"However, a recent post-marketing survey in Japan revealed that interstitial pneumonia occurred in 4 among approximately 2 000 Japanese patients treated with sorafenib.",1
"We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).",1
"Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.",1
"Her management consisted of regular blood transfusions aimed at haemoglobin above 8.5 g/dl, antimicrobials, oxymetholone, low dose prednisone and folate.",0
We report two patients who developed intense livedo reticularis clearly related to the administration of interferon alpha 2b as an adjuvant therapy for melanoma.,1
"We report the case of a 17-year-old male who developed chest pain, elevated cardiac biomarkers, and acute left ventricular dysfunction following a single dose of methylphenidate.",1
A single-pass tunneling technique for CSF shunting procedures.,0
Total resection revealed that the lesions were composed entirely of fatty tissue.,0
"A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.",1
Preexisting hyperparathyroidism is the most common cause of post-transplantation hypercalcemia.,0
Severe neurotoxicity with methyl G: CALGB experience.,1
"BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.",1
"Five months after the patient's erythropoietin therapy was discontinued, his A1C value increased to 8.8%, leading us to conclude that management of the insulin dose may have been different without the falsely lowered A1C levels.",0
Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium.,1
When co-trimoxazole was stopped the red cell aplasia resolved.,1
GCV-resistance during VCV-prophylaxis was rare after renal transplantation.,0
CONCLUSIONS: This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms.,1
"Therefore, patients on long-term therapy with atypical antipsychotic drugs should be screened periodically for TD.",0
We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.,1
Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.,1
I saw two patients with kala-azar resistant to sodium stibogluconate who developed cardiac arrest after amphotericin infusion (in spite of tolerating a test dose).,1
"Electron microscopy demonstrated electron-dense granules, free and membrane-bound, within macrophages and fibroblast-like cells.",0
Six consecutive patients with HIV infection and NCPH were the subject of this series.,0
"We present the case of a postictal patient with lethargy, hyperammonemia, otherwise normal liver function tests, and a therapeutic valproic acid level.",1
"METHODS: Prospective, interventional, single case report.",0
Five of these six patients had renal failure.,0
Bilateral anterior uveitis associated with clomiphene citrate.,1
A 22 year old female was admitted to hospital two hours after ingesting 4 g of dapsone.,0
"The AVM was embolized without incident, however, the AVF was not accessible.",0
Severe heparin associated thrombocytopenia is a rare complication of heparin therapy.,1
"In addition, immunohistochemical findings of a dense CD8+, TIA1+ and granzyme B+ lymphoid infiltrate within a biopsied lesion provide indirect evidence of functional T-cell activation induced by treatment.",0
Two ajmaline tests were both negative and ruled out the diagnosis of BS.,0
"Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).",1
"Despite the significant weight loss, 4 of the 5 patients continued to take the drug due to its efficacy.",0
The clinical response was reflected by an increase in circulating interleukin (IL) 10 and a decrease in IL-6 and IL-8 serum levels during treatment.,0
"In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.",1
OBJECTIVE: The purpose of the study is to investigate the relationship between inhaled or intranasal adrenergic agonists and corticosteroids and the development of central serous chorioretinopathy (CSC).,0
Hepatopathy subsided after the cessation of carbamazepine and lynestrenol.,1
A patient with chest pain was found to have obstructive hypertrophic cardiomyopathy.,0
In this case this activation of the calcium sensing receptor was triggered by amikacin.,0
"The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.",1
"Infants, particularly neonates, are not merely small adults requiring smaller dosages, but rather uniquely different patients.",0
Drug provocation test is a controlled drug treatment which aims at making diagnosis of hypersensitivity reaction to drugs.,0
Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.,1
Possible heart failure exacerbation associated with rosiglitazone: case report and literature review.,1
Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.,1
"The episodes became more frequent in the following months, causing several falls and requiring visits to the emergency department, but no acute coronary event was diagnosed.",0
The subjects received the urinary sediment test before and during the study for screening urinary tract infection and the study was discontinued when urinary tract infection was found.,0
Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.,1
"A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation.",1
Recent efforts have focused on heightened surveillance to detect contamination before transfusion to limit recipient morbidity and mortality.,0
"CASE SUMMARY: A 46-year-old African-American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B, then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time.",1
Liver biopsy showed chronic aggressive hepatitis with subacute hepatic necrosis.,0
PURPOSE: We evaluated the in vitro hemodialysis ratio and subsequent toxicity and pharmacokinetics of ifosfamide in an anephric patient with Wilms' tumor.,1
"Clonidine, oral and patch, has been used in adults for the treatment of hypertension and Tourette's Syndrome.",0
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
"Patient 1 had an arterial thrombosis, whereas Patient 2 had a venous thrombosis.",0
"We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection.",1
Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.,1
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).,1
We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.,1
"We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.",1
Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.,1
Parenteral challenge with suspected sensitizing agents confirmed methicillin as the likely offender.,0
"The two cases occurred on days 2 and 3 post-BMT, respectively.",0
Ulcer became worse after tobramycin and gentamycin treatment for 2 days.,1
Spinal shock protocol with high-dose methylprednisolone was begun without change.,0
"Three patients showed marked improvement (decrease in VAS, >75%).",0
"BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.",1
METHOD: Recombinant human growth hormone (rhGH) is a newly approved treatment for weight loss and wasting in patients with AIDS.,0
Ticlopidine-induced interstitial pulmonary disease: a case report.,1
"Propafenone's distribution, clearance, and structural similarity to propranolol contribute to its central nervous system effects.",0
"Immune reconstitution inflammatory syndrome (IRIS) is a recently described entity in which severely immunodepressed HIV patients, after being started on HAART, develop inflammatory reactions to several pathogens.",0
The results of histopathologic examination of the colonic mucosa suggested ulcerative colitis.,0
"A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.",1
TSH remained persistently raised and the patient became thyrotoxic.,0
Multifocal ERG showed abnormalities that sometimes correlated with the visual field appearance and confirmed that the deficit occurs at the retinal level.,0
Bucillamine is used as an antirheumatic drug that is structurally analogous to D-penicillamine.,0
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.,1
Development of bilateral herpes zoster following thoracoscopic splanchnicectomy.,0
Syncope induced by propranolol in hypertrophic cardiomyopathy.,1
PURPOSE: To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine.,1
Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure.,1
Transient phenytoin induced IgA deficiency and permanent IgE increase.,1
"Seven months after undergoing a syngeneic PBSC transplant for AML, our patient presented with fever without localizing signs.",0
Prior neurologic illness and the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).,1
Immunosuppression elicited by the extensive administration of prednisolone was suspected for the initiation of the generalized mite infestation.,1
"We enrolled eight out of 155 patients with advanced melanoma in a multicentre phase II trial that evaluated the activity and tolerability of ipilimumab, a fully human, anti-CTLA-4 monoclonal antibody ( www.clinicaltrials.gov ; NCT00289627; CA184-008).",0
"An extensive MEDLINE search located 22 other reports of patients who developed HDAs, sometimes associated with thrombosis, but whose platelet counts did not decrease.",0
"It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called ""3-week sulphasalazine syndrome"", a rare, but often fatal, immunoallergic reaction to sulphasalazine.",1
"To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.",1
Reversible pheripheral edema in female patients taking proton pump inhibitors for peptic acid diseases.,0
Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.,1
Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation.,1
It is sometimes the sorrow of failed action and sometimes the sorrow of failed conduct.,0
Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.,1
"In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.",1
We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.,1
A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.,1
We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma.,1
Infliximab-induced lupus in Crohn's disease: a case report.,1
OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis.,1
The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.,1
"Reversal reactions are caused immunologically by enhanced cell-mediated (Th-1) immunity to Mycobacterium leprae, resulting in inflammation of infected tissues, such as skin and nerves.",0
In two patients this was the sole chemotherapeutic agent used.,0
"A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.",1
Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.,1
"At this psychiatrist visit, sertraline 50 mg/day was added for her depression, and was continued after a geriatrician visit in October.",0
One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.,1
Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.,1
"CONCLUSION: Although the mechanism is not clear, these cases add to several other reports concerning the sudden emergence of obsessive-compulsive symptoms and anxiety symptoms in children treated with atypical antipsychotics.",0
Rhabdomyolysis associated with the use of intravenous vasopressin.,1
Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.,1
"Although it is difficult to be certain of the direct link of amiodarone on the basis of a single case, it is reasonable to presume that this histopathology is associated with amiodarone-induced hypothyroidism and that involution changes represent the hypofunctional status of this drug-induced disorder.",1
"BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.",1
Acute leukaemia during tamoxifen therapy.,1
STUDY DESIGN: Case report.,0
"An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum.",1
Fatal hepatitis after long-term pulse itraconazole treatment for onychomycosis.,1
Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol.,1
Correction of serum electrolyte imbalance prevents cardiac arrhythmia during amphotericin B administration.,1
"BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.",1
"CONCLUSIONS: Neurosurgeons will be faced with another devastating complication of thrombolytic therapy, as long as the available drugs are being used.",0
"Although some reports suggest that treatment with recombinant erythropoietin may affect A1C values in patients undergoing hemodialysis, we know of no evidence to support this interaction in patients with chronic renal insufficiency who are not undergoing hemodialysis.",0
CONCLUSION: Significant ocular complications such as an irreversible decrease of visual acuity may develop in patients treated with pegylated interferon.,1
"Other features of this adverse drug reaction were unremitting fever, leukocytosis with eosinophilia and atypical lymphocytosis, and proteinuria.",0
We report the case of a patient suspected of voluntary massive poisoning by ethylene glycol.,0
"Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as ""retinoic acid syndrome."" This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.",1
This case describes the complications and successful treatment of high-dose intrathecal morphine overdose.,0
Most cases are managed by oral surgeons with only a handful of reports appearing in the otolaryngology literature.,0
A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.,1
"Diagnosis, treatment, observation and outcome of fetal supraventricular tachycardia in a twin pregnancy.",0
"Although the great majority of these events occur at sites of vascular interruption, major gastrointestinal, retroperitoneal, genitourinary, and central nervous system hemorrhage are known to occur.",0
Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.,1
"Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy.",1
Phone followup was attempted.,0
The results of modeling studies have suggested and clinical investigations have confirmed a major pharmacokinetic advantage for exposure of the peritoneal cavity to certain chemotherapeutic agents compared with exposure of the systemic circulation when these drugs are delivered through the intraperitoneal route.,0
We report a case culture-negative interface abscess following LASIK that was successfully treated with antibiotics and povidone iodine.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
"DISCUSSION: Colchicine, the most important drug in treatment of FMF, can cause myopathy in patients with impaired renal and hepatic function.",1
"During the following years, the patient was retested regularly.",0
The overall response rate of these 24 refractory lymphomas to gemcitabine-containing regimens was 46%.,0
Refractory hypoglycemia from ciprofloxacin and glyburide interaction.,1
"Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.",1
Central venous catheter (CVC)-related infections were most frequent (n = 20) followed by otitis externa (n = 6) and pneumonia (n = 5).,0
Malignant hyperthermia: clinical course and metabolic changes in two patients.,0
Dasatinib-induced pleural effusions: a lymphatic network disorder?,1
"METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.",1
A case report.,0
We report a case of chronic use of HCQ associated with torsade de pointes.,1
"Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.",1
"Although they had only a few nodules at diagnosis, the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients.",1
"Three weeks after traveling to Arizona, a 13-month-old, female Labrador retriever developed draining tracts in the right hind limb.",0
"Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.",1
"Therefore, it is reasonable to conclude that: 1) 2-CdA can induce durable complete remission in MCD patients but unfortunately it cannot cure the disease; 2) the possibility that 2-CdA may accelerate the transformation of MCD to NHL cannot be ruled out.",1
A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.,1
Leukocyte histamine release test with salmon calcitonin and serum tryptase levels at baseline and after intramuscular challenge test were performed.,0
A case of colchicine-induced rhabdomyolysis is reported.,1
"She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.",1
Ishihara color plates showed normal color vision.,0
"Ultimately, the choice of treatment will depend upon the patient's risk of recurrence and progression.",0
One patient had an implant of serous papillary carcinoma of low malignant potential at the trocar sites after laparoscopic oophorectomy.,0
The cases described suggest the need for caution when considering tricyclic pharmacotherapy in juveniles with severe depressive disease.,0
"Physicians should be careful not to rule out the diagnosis in patients of high-risk ethnic backgrounds just because of atypical clinical features, as our data indicate that MEFV mutations are sometimes demonstrable in such patients.",0
"In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.",1
He began smoking again within 48 hours.,0
This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.,1
Cutaneous mycobacterial infection post intravesical BCG installation.,1
"Diagnosis of attention-deficit/hyperactivity disorder by family physicians and pediatricians was most commonly based on brief behavioral descriptions by parents and, infrequently, by use of rating scales.",0
"Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).",1
Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.,1
CONCLUSIONS: We report the association of postoperative chylothorax treated with somatostatin analog (octreotide) and necrotizing enterocolitis in an infant following aortic coarctation repair.,0
Cardiac hypersensitivity and myopericarditis have been reported during long-term treatment with mesalazine.,1
We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.,1
"A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.",1
Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.,1
"In the second case, mild atypical change by presence of nuclear enlargement and rare mitotic figures were noted and PCNA, KI67 levels were less than 2%.",0
Acute INH toxicity should be suspected in children presenting with seizures with or without fever.,0
"This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.",1
"After eyelid reconstruction the patient's visual axis has remained unobstructed, and amblyopia has been thus far averted.",0
Circulating anticoagulant in the procainamide-induced lupus syndrome.,1
The case of a 86-year-old woman with obstructive ileus due to advanced pancreatic cancer is presented.,0
These results indicate that the hyponatremia in this case was due to SIADH and that SIADH was caused by an increased release of vasopressin probably because of the antiviral drug (acyclovir) or infection of varicella zoster virus (VZV) in a single dermatome.,0
Catheter-related cutaneous aspergillosis complicated by fungemia and fatal pulmonary infection in an HIV-positive patient with acute lymphocytic leukemia.,0
OBJECTIVE: To describe a case of cefazolin-induced leukopenia in a critically ill patient who developed this adverse reaction upon rechallenge with cefoxitin.,1
A case of Erythema Multiforme Bullosum in patient of lepromatous leprosy with pulmonary tuberculosis due to Rifampicin is described.,1
"As the child's adoptive parents controlled medication access, they were investigated by social welfare agencies.",0
Diclofenac-associated hepatitis.,1
Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review.,1
"In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.",1
The safety and tolerability profile of rFVIIa in bleeding neonates was also evaluated.,0
The cough is considered to be a class-related adverse effect with cross-reactions between ACE inhibitors routinely reported.,0
METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.,1
Successful repair of myocardial free wall rupture after thrombolytic therapy for acute infarction.,0
The concentration of pseudoephedrine in blood and liver specimens was measured using gas chromatography-mass spectrometry and was determined to be 14.4 mg/L in the blood and 16 mg/kg in the liver.,0
Renal damage associated with long term use of lithium carbonate.,1
"While the true correlation remains unknown, allergic cross-reactivity may occur between sulfonamide antibiotics and non-antibiotics, such as loop diuretics.",0
The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD.,0
An intensive search revealed that this patient was receiving coumadin that was given by the mother.,0
"We report a case of severe anemia, which responded well to steroid therapy, in a patient receiving IL-2 plus IFN-alpha for metastatic renal cell carcinoma.",1
"In 3 patients, the syndrome was exacerbated after conversion of therapy to another antiepileptic drug with an aromatic ring chemical structure.",0
Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.,1
The patient in this case report was mentally impaired and had severe drug-induced gingival enlargement.,0
She then was restabilized with warfarin.,0
"Epoprostenol is a vasodilator that is produced by vascular endothelial cells and is currently the ""gold standard"" therapy for patients with severe primary pulmonary hypertension or pulmonary hypertension secondary to collagen vascular disease.",0
This case raises concern about the possible adverse consequences of hormonal manipulation in treating infertility.,0
We report 3 cases in whom aspirin was indicated for secondary prophylaxis of myocardial infarction but in whom a remote history of an untoward reaction to it prevented its initial use.,0
"No severe side effects occurred, except for slight pain in the nodules after infusion and an urticarial reaction at the tumor sites.",0
"Elevated intraocular pressure was noted on average 28 days after presentation (range, 8-69).",0
"Major points illustrated are, (1) occurrence of HIT with any dose or form of heparin; (2) misperceptions on the diagnostic criteria; (3) correct (thrombin inhibitors) and incorrect (platelet transfusions and warfarin) management; (4) influence of management strategy on clinical outcomes; (5) severity of the syndrome; and (6) potential for both anamnestic response to heparin and disappearance of HIT antibodies over time.",1
Histopathology of maculae showed extensive collections of melanophages in the upper dermis.,0
Both patients presented with abdominal pain and turbid dialysis effluent with or without fever.,0
All isolates were believed to be clinically significant.,0
"Descemet folds and an atypically large amount of stromal edema were present in both cases, and there appeared to be possible endothelial dysfunction as well.",0
We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.,1
This case report describes a rare combination of facial dermatologic toxicity and ectropion.,0
"The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.",1
"Nitrofurantoin, one of the antimicrobial agents which should be chosen for the prophylactic treatment of recurrent urinary tract infection, may be prescribed in the conventional form or, alternatively, as macrocrystals.",0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
A case of SIADH induced by mizoribin administration.,1
"However, clinical manifestations and treatment options have rarely been described in the pediatric literature.",0
During chemotherapy suggested pathogenetic factors were monitored without observing any significant abnormality.,0
Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.,1
We report a case of dermal alternariosis occurring in a woman treated with corticosteroids for dermatomyositis.,0
"Thus, the possible in vivo effects of insulin on adipocytes were clearly observed in this case of insulin-induced lipohypertrophy.",1
"This report documents the occurrence of severe glomerular pathology associated with continuous, daily antituberculous therapy.",0
"Three of the patients had the carcinoid syndrome and one a renal carcinoma, and all were treated with interferon-alpha 2b or 2a (IFN-alpha 2b, 2a) with doses ranging from 1.5 x 10(6) U daily to 18 x 10(6) U three times weekly.",0
"Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation.",1
"INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.",1
The development of new pharmacological agents with varied properties and actions has increased the risk of serotonin syndrome as a clinical diagnosis.,0
After the surgery a Pet scan was positive for a hot-spot in the left colon.,0
Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers.,1
We describe a patient who experienced a lichenoid eruption after the initiation of salsalate for relief of arthritic pain.,1
"After 2 months, her mental status and neurologic status had recovered completely.",0
"Over a 5-year period, we observed three patients with a 3-15-year history of migraine, who received sumatriptan for acute headache.",0
Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.,1
"Herbal remedies are commonly used for psychiatric problems, but there is virtually no data about the use of these substances by young persons or by patients in treatment.",0
Physicians and patients must use more caution with teratogenic prescription drugs.,0
Laryngeal necrosis after combined chemotherapy and radiation therapy.,0
It was concluded that potassium loss occurred by a non-renal (intestinal) route in phosphate-induced hypokalemia.,1
She subsequently developed severe post-herpetic neuralgia requiring the recommencement of gabapentin and amitriptyline.,0
Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.,1
"Upon a chlorpromazine minimal effective dose reduction, target behaviors increased and dosage was returned to prior levels with the conclusion that chlorpromazine was controlling the target behaviors.",0
Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia.,1
"A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.",1
"The reported effects of these agents in increasing total Hb, however, have been inconsistent and there have been no studies on the combination of these medications.",0
"The only adverse effect was atrioventricular block in two children, which was completely reversible.",0
CONCLUSION: Lipoid pneumonia as a result of mineral oil aspiration still occurs in the pediatric population.,1
This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.,1
Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.,1
Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.,1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
This is the first report of UFT-induced scleroderma-like reaction.,1
"Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.",1
Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy.,1
"Postoperatively, the first two patients treated with 1 to 2 cc of thrombin were slow to awaken; one had evidence of vasospasm by transcranial Doppler ultrasound studies and multiple infarcts on cranial computerized tomography, while the other had a moderate-sized frontal hematoma with intracranial hypertension.",1
Possible mechanisms underlying her response to this form of treatment are discussed.,0
Phenytoin (Dilantin) is typically employed as prophylactic anticonvulsant in this setting.,0
"Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.",1
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.,1
"This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.",1
"E. avium bacteremias were polymicrobial in seven cases; in six cases, the coisolates were gastrointestinal organisms.",0
Patients treated with 5-ASA compounds who experience acute inflammatory symptoms or clinical deterioration not related to their gastrointestinal disease should be screened to rule out a lupus-like reaction.,0
"METHODS: We reviewed the records of two patients with a clinical diagnosis of Acanthamoeba keratitis, one with culture-proven Acanthamoeba and the other with a suspected Acanthamoeba infection.",0
Spinal cord tolerance is currently accepted as about 50 Gy in 1.8-2 Gy fractions.,0
"While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.",1
Two courses of tinidazole (the second in combination with percutaneous aspiration of the abscess) were required to achieve cure.,0
She had Crohn's disease since age 9 years and was on chronic TPN.,0
"Like other myeloproliferative diseases, ET is associated with an increased risk of development of acute leukemia (AL).",0
"BAL fluid also grew Mycobacterium kansasii, for which he received combination anti-mycobacterial therapy.",0
Mitomycin C-related hemolytic uremic syndrome in cancer patients.,1
"For patients who suffer from osteogenic sarcoma and have anaphylactic reactions to MTX, this desensitization protocol will allow these patients to continue with needed therapeutic or palliative chemotherapy.",1
We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.,1
Thrombotic microangiopathy associated with chemotherapy: case report and review of the literature.,0
"Approximately 15 min after the first administration of nebulised morphine the patient became markedly bradypneic (respiratory rate: 4-5 bpm), hypotensive (BP 70/40 mmHg), and responded only partially to command.",1
"After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.",1
"Moreover, as the pathophysiology of this disorder becomes less of a hypothesis and more of an understood entity, it is likely that treatment options will broaden beyond the use of daily prophylactic colchicine.",0
METHOD: Single case report.,0
Pharmacokinetically induced benzodiazepine withdrawal.,0
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
"One wk later, after injection in the right arm, skin lesions and pruritus were seen.",0
Diagnostic procedures aimed to explain lower leg edema are not uncommon in the age group of women suffering from climacteric and menopausal symptoms.,0
The impressive and significant success rate for complete resolution of verrucous lesions without subsequent scarring has shown this approach to be an effective treatment for plantar warts.,0
Anaphylactic reaction to oral prednisone: a case report and review of the literature.,1
The possibility that thiocyanate level in a newborn is unreliable as indicator of sodium nitroprusside overdosage is considered.,0
"In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.",1
"The patient had complete recovery of neurologic function to his preoperative baseline after the second procedure but required a third procedure in which anterior discectomy and fusion at C4-C5 was performed, which led to improvement of his preoperative symptoms.",0
Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients.,1
Sunburn may sometimes be a major injury in psoralen users because high doses or inappropriate use of the drug may render the skin extremely sensitive.,1
"During her hospital stay, her sodium level and serum osmolality increased and her urine osmolality decreased, whereas her lithium levels remained within normal limits.",0
"When measured, the serum lithium level had increased 4-fold during acyclovir therapy.",1
"Patients have the right to adequate and safe pain relief in hospitals, but many continue to experience unrelieved pain.",0
"The number of suspected ADRs remains small, especially when compared with the magnitude of human clinical use of 1% lindane preparations in the United States (50 million ounces during the past five years).",0
"Although high-dose methotrexate has been shown to be useful in the treatment of primary osteogenic sarcoma, the tumoricidal effects of therapy appear to have caused a fatal rise in intracranial pressure.",1
A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum.,1
Experimental evidence indicates that corticosteroid administration causes a reduction in T lymphocytes mediated by suppression of cytokines.,0
Two cases of mequitazine-induced photosensitivity reactions.,1
"Thalidomide neuropathy is often associated with proximal weakness and may progress even after discontinuation of treatment, in the phenomenon of 'coasting'.",1
Laboratory test results revealed elevated liver function test values.,0
Glucocorticoids may be useful as short-term palliative therapy for acute exacerbations of Crohn disease.,0
"A whitish plaque in the lips and bilateral buccal mucosa, burning, taste disturbance, and xerostomia were observed.",0
"The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.",1
"A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.",1
A patient with a large hydatid cyst of the left lobe of the liver developed metabolic acidosis following rather liberal use of cetrimide-chlorhexidine solution as a scolicidal agent.,1
Gynecomastia associated with theophylline.,1
We report the case of a 60-year-old woman who developed erythema and erosions in the axilla and groin while on PLD for breast cancer.,1
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.,1
Clostridium difficile toxin-induced colitis after use of clindamycin phosphate vaginal cream.,1
(3) A 61-year-old woman with active refractory Wegener's granulomatosis who developed respiratory insufficiency due to aspergillus and pseudomonas pneumonia.,0
A case report of a patient with probable cisplatin and bleomycin-induced TMA is presented.,1
"Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.",1
"After treatment with recombinant tissue plasminogen activator, the patient's hemodynamic status improved, permitting the liver transplant to be completed.",0
"Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.",1
"Patients treated with captopril who develop ""atypical cholangitis"" should be suspected of having captopril-associated liver damage.",1
"Aluminum intoxication, along with other factors, was considered to be the cause of TC development.",1
A case of acute cardiomyopathy and pericarditis associated with methylphenidate.,1
This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients.,1
CD20-negative T-cell-rich B-cell lymphoma as a progression of a nodular lymphocyte-predominant Hodgkin's lymphoma treated with rituximab: a molecular analysis using laser capture microdissection.,1
An adult male presented with central blindness after ingesting methanol.,1
RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.,1
None of these patients met the DSM-IV criteria for a major depressive disorder.,0
Clinical presentation spreads from almost asymptomatic patients to critically ill patients with pulmonary oedema or frank cardiogenic shock.,0
Temozolomide was restarted 2 months later; the patient again developed a fever.,1
"The sixth woman, with an empty sella turcica after radiation therapy of a pituitary adenoma, had an endometrial mullerian adenosarcoma at the age of 40 years after 16 years of estrogen therapy.",0
We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.,1
"Idiosyncratic pulmonary reactions to nitrofurantoin are not unusual, often presenting as eosinophilic pneumonia.",1
RESULTS: Delay in clinical recognition and treatment in our first case resulted in death due to multiorgan failure (MOF).,0
A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.,1
"Therefore, preventive measures should be taken against colonization by Candida of the palatal mucosa and the dentures.",0
"This was postulated to be due to the tacrolimus therapy, which was withdrawn.",0
"Clozapine is an atypical antipsychotic drug, and there have been case reports that clozapine may be an effective treatment for tardive dystonia.",0
We report a case of a 69-year-old male patient who came to our attention for macular edema in hemiretinal vein occlusion.,0
Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.,1
"After switching, 11 got better, 29 remained stable whereas seven got worse, according to the Global Improvement.",0
A 13-year-old boy was diagnosed as acute lymphoblastic leukemia following radiotherapy and chemotherapy for treatment of medulloblastoma.,0
"Postoperatively, the first two patients treated with 1 to 2 cc of thrombin were slow to awaken; one had evidence of vasospasm by transcranial Doppler ultrasound studies and multiple infarcts on cranial computerized tomography, while the other had a moderate-sized frontal hematoma with intracranial hypertension.",1
There were no perioperative or long-term complications of the single-pass technique.,0
Withdrawal emergent syndrome (WES) is a subtype of tardive dyskinesia that has been reported in children who were taken off antipsychotic therapy.,0
"Administration of the drug for 8 days did not effectively shorten the recovery period compared with the average reported in the literature without the drug, and may have triggered additional iatrogenic complications.",0
Additive pulmonary toxicity with melphalan and busulfan therapy.,1
A combination of behavioural and cognitive adverse effects is illustrated in this case report of a recurrent triazolam-induced eating disorder.,1
"We present a unique case of a patient, without any prior history of a movement disorder, who developed tics following a single dose of atomoxetine that did not improve until interventional therapy was initiated.",0
Palliative radiation therapy was given.,0
"This case report emphasizes the importance of routine vitamin D supplementation in all patients on long term cholestyramine therapy, and indicates that even in patients with small intestinal disease or resection, oral preparations of vitamin D or its metabolities and analogues may be effective.",0
"The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease.",1
"The authors present a case report of a granulomatous reaction leading to urethral prolapse, 3 months after the transurethral injection of calcium hydroxylapatite.",1
"An uncommon manifestation of phototoxicity, photo-onycholysis results in the separation of the distal nail from the nail bed.",0
Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.,1
This report describes a case of acute compromise of renal function associated with hypotension in a 7-year-old boy treated with the ACE inhibitor lisinopril and the ARB losartan.,1
The association between heparin and priapism is often recognized; abnormal platelet aggregation could play a role in the pathogenesis of this side effect.,1
Pulmonary gold toxicity.,1
A purulent exudate was aspirated from the abscesses under computed tomographic guidance.,0
This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.,1
Physicians should be aware of the possible association between the use of alteplase and the development of subfascial hemorrhage.,1
"CONCLUSION: It is suggested that antibiotic-induced endotoxemia of a patient with septic endogenous endophthalmitis produced endotoxin-induced uveitis under an upregulation of HLA and endotoxin activated macrophages may release cytokines, followed by fibrin formation and subsequent granuloma.",0
Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.,1
"Weakness of the right arm, focal seizures, lethargy and confusion appeared on day 10.",0
Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit.,1
These neurological symptoms should be added to a growing list of important complications of DIHS/DRESS because of the high mortality rate associated with them.,0
"So far, few cases of pulmonary side effects caused by ticlopidine have been reported.",1
"We report in detail an unusual adverse reaction to infliximab therapy, a drug-induced lupus-like clinical syndrome.",1
"The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.",1
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
"The patient had been treated with many commonly used medications, including 13-cis-retinoic acid, a relatively new drug with apparent therapeutic benefit in hyperkeratotic dermatoses.",0
He underwent liver biopsy and biochemical screening to evaluate whether he would benefit from interferon (IFN) treatment.,0
Desipramine and testicular swelling in two patients.,0
"When the thyrotoxicosis recurred, accompanied by a severe psychotic reaction, administration of antithyroid medication was recommenced.",0
"Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset.",1
Previously reported cases of persistent proximal right umbilical vein have shown a variety of other malformations but a single umbilical artery has been the most consistent.,0
"The shunt infection was controlled by removal of the shunt and a combination of systemic and intraventricular administration of amikacin, and oral administration of ofloxacin.",0
A 55-year-old Caucasian man was admitted to hospital with triple vessel disease.,0
A 72-year-old woman was treated daily with two solutions including Tathion eye drops for senile cataract for two years and three months.,0
"A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.",1
"However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).",1
Acute delirium resulting from levofloxacin therapy is an exceedingly rare complication that has been thought to occur more commonly in elderly patients.,1
The second patient developed similar symptoms on day 3 of treatment with 2500 mg/m2.,0
"BK virus-associated nephropathy (BKVN) has become recognized as an important cause of allograft dysfunction in renal transplant recipients and despite reduction in immunosuppression, 30-40% of recipients ultimately progress to allograft loss.",0
Disturbance of GABA metabolism in pyridoxine-dependent seizures.,0
CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.,1
"None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.",1
"BACKGROUND: Recombinant activated factor VII (rFVIIa), originally developed for the treatment of life-threatening bleeding in hemophilic patients with inhibitors to factors VIII or IX, has been increasingly used to control hemorrhage unresponsive to conventional treatment, in the absence of a defined coagulopathy or thrombocytopathy.",0
OBJECTIVE: To report the safe use of fluorouracil in a patient with breast cancer who had allergic reactions to capecitabine.,1
Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression.,1
The present case is a young adult who had severe almost continuous hiccups for 3 years after placement of a feeding gastrostomy and Nissen fundoplication.,0
"To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported.",1
This latest (third) report suggests that the safety profile should be reexamined and at least raises the question of potential renal toxicity of interferons in MS.,1
The combination of levodopa and peripheral dopadecarboxylase inhibitor is the most efficacious symptomatic treatment for Parkinson's disease.,0
"After 4 weeks, the necrotic tissue sloughed off, the early signs of healing appeared making surgical debridement possible.",0
Blood and urine samples were collected over a 98 h period for monitoring the efficacy and adequacy of FAB treatment.,0
His akathisia symptoms worsened thereafter.,0
Anaphylaxis to intrathecal diamorphine.,1
Patient B continued at 80% of standard dose (2000 mg/m2) and symptoms resolved without further intervention.,0
Skin rash and splinter hemorrhages from ganciclovir.,1
"A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",1
Successful treatment of influenza A virus by oseltamivir in bone marrow transplant recipients.,0
"Although rare, there have been reported cases of primary cutaneous T-cell lymphoma occurring in this population.",0
We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.,1
"A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.",1
The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.,1
Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.,1
Acute cardiogenic pulmonary edema and other causes of respiratory distress were ruled out; diagnosis of Adult Respiratory Distress Syndrome (ARDS) was made.,0
Further post-marketing surveys are required.,0
The muscle rigidity and hyperpyrexia were unresponsive to intravenous benztropine but resolved within one hour of intravenous dantrolene 2 mg/kg.,0
For effective treatment of bacterial osteomyelitis a bone biopsy is sometimes unavoidable and indicated.,0
Two patients did not receive corticosteroids or parenteral nutrition.,0
We will also discuss the unusual nature of this type of burn and the course of phototoxic lesions and their differences from a typical sunburn.,0
A failure to rely on serum free levels of the anti-convulsant under these circumstances can easily result in poor clinical decisions.,0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
Herein is reported an unusual case of coexistent warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for thromboembolic phenomena associated with marantic endocarditis and bronchial adenocarcinoma.,1
"In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.",1
"A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.",1
"As part of the comprehensive treatment, strict reverse isolation and granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy were applied.",0
"CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.",1
Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.,1
The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped.,1
Platelet count less than SHARP: what does a case series reveal?,0
Several hypotheses are advanced to explain the failure of bone erosions to heal.,0
"To date, there have been few reports of visual disturbances associated with BTX-B use.",1
Additional predisposing factors were the patient's age and difficulty in urination due to benign prostatic hypertrophy.,0
Clinical manifestations range from asymptomatic to fulminant in nature.,0
Gold nephropathy: tissue analysis by X-ray fluorescent spectroscopy.,1
"The polymorphic UGT isoenzyme, UGT1A1 has genetic variants which decrease in SN-38 glucuronidating capacity and could help predict irinotecan-associated toxicity.",0
This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli.,1
"The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis, and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities, the combination use of these drugs should be avoided.",1
Protease inhibitor-associated angiolipomatosis.,0
Salmonella meningitis and multiple cerebral abscesses in an infant.,0
"In addition, the deletion of chromosome no. 20, described as characteristic for PV, was found in 3 cells.",0
Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.,1
An insulin-dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma.,1
"Laboratory studies showed leukocyturia, thrombocytopenia, severe anemia, and tarry stools.",0
The patient was reluctant to resume chemotherapy for his Hodgkin's disease because of his previous presumed skin infections.,0
An almost total breast reduction was performed; 5 kg of right breast tissue and 7 kg of left breast tissue were excised.,0
METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.,1
A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide.,1
We reviewed the cases of PnM in patients with DM treated with CsA.,0
Morphea after bromocriptine therapy.,1
Histological studies confirmed the diagnosis of KS and documented its complete regression.,0
"From these data, acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d-penicillamine therapy.",1
Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.,1
Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.,1
This report is intended to alert others to the possible development of this serious complication following short-term Decadron therapy.,0
Immunotherapy with imiquimod 5% cream for eyelid nodular basal cell carcinoma.,0
We describe the clinical course of an EBV seronegative 11-yr-old boy who underwent double lung transplantation and subsequently developed PTLD in the graft.,0
Triazolam-induced nocturnal bingeing with amnesia.,1
"In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.",1
Localized dyskeratotic plaque with milia associated with sorafenib.,1
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
CASE REPORTS: Case 1: A 53-year-old male alcoholic received cyanamide treatment for 4.5 months and completely abstained without cyanamide treatment for 6 years.,0
Video distraction initially inhibited vomiting but the treatment effects were not maintained.,0
DESIGN: Observational case report.,0
Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?,1
"Thus, in many cases, the possible benefit of thrombolysis during CPR seems to outweigh the potential risks.",0
"Of these, 14 patients underwent castration (two patients) or received LH-RH analogue (12 patients) plus chlormadinone acetate for combined androgen blockade.",0
A woman with Cushing's syndrome after use of an Indonesian herb: a case report.,0
"The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.",1
The difference in DGTX concentration between the unprocessed and dialysed samples was the amount of DGTX bound to plasma proteins and the small fraction of unbound DGTX being relevant for the therapeutic and toxic effects of the drug.,0
Increasing warfarin dosage reductions associated with concurrent warfarin and repeated cycles of 5-Fluorouracil therapy.,0
The patient received two cycles of HDARAC over the course of a ten-week period.,0
A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.,1
We describe a life threatening side effect of acute epoprostenol infusion (pulmonary edema) in a patient with pulmonary hypertension associated with limited scleroderma and discuss its management and potential etiology.,1
OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy.,1
"We report a myeloma patient who developed severe paralytic ileus during bortezomib therapy, which presented in the context of progressive constipation without other known causes and which regressed promptly with medical management after drug cessation, suggesting a direct causal relationship.",1
"Therapy with pyrimethamine, sulfadiazine and folinic acid resulted in total lesion healing although central vision was lost.",0
Eyes from two individuals examined at autopsy showed significant changes.,0
"Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist.",1
Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.,1
Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.,1
Fulminant hepatic failure developed in a 24-year-old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism.,1
"To our knowledge, this is the first clear report of reactivation of ""latent"" Histoplasmosis after anti-TNF-alpha therapy.",0
No anti-Xa activity was demonstrated in breast milk.,0
"BOOP is considered as a nonspecific response to many types of lung injury, including drugs, radiation, an underlying hematologic malignant neoplasm, autoimmune diseases, bacterial or virus infection, or an underlying lung disease, or occurs idiopathically.",0
"One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment, none of which was clinically significant.",1
"The patient was readmitted with symptoms of rhinorrhea, poor feeding, and decreased activity level.",0
"As in this case, infection may be systemic and not confined to the intestine.",0
Evidence from previous studies of neuroleptic side effects suggests that acute dystonic reactions are rare in elderly patients.,0
A 13-month-old child with lamellar ichthyosis and numerous cutaneous and systemic infections died following an abrupt episode of severe hypotension.,0
Intrauterine contraceptive device-associated pelvic actinomycosis caused by Actinomyces urogenitalis.,0
The cases reported in the literature are all secondary to dental or periodontal disease.,0
Eight of the 14 women used no contraception at the time of the exposed pregnancy; 13 of the 14 women did not use two forms of contraception.,0
"The optic nerve appeared healthy, with no visible swelling in each eye.",0
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
Lithium carbonate was a useful alternative to neuroleptics in managing the adolescent's disturbed behavior.,0
A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.,1
"Here, we report a case of angio-oedema associated with VRC therapy.",1
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.,1
Exacerbation of schizophrenia associated with amantadine.,1
A review of the literature is also presented.,0
"The temporal course of CNV, the presence of a chorio-retinal shunt, and the autofluorescence pattern in the fellow eye let us to speculate that the CNV was related to the vascular occlusive process.",0
She was treated with intravenous fluids and discharged.,0
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
AIM: To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin).,1
"The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.",1
Reversible cholestasis with bile duct injury following azathioprine therapy.,1
This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.,1
She had a history of diabetes and angina pectoris.,0
"Abdominal CT showed diffuse swelling of the pancreas, with two distinct masses in the corpus and the tail.",0
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
"Antiretrovirals from three drug classes, nucleoside analogs, nonnucleoside analogs, and protease inhibitors, can be combined to achieve viral suppression.",0
FINDINGS: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression.,1
"For this goal, a moist environment may be the optimal choice for topical therapy.",0
Recognition of this acute drug-induced state can lead to appropriate short-term pharmacotherapy and can prevent misdiagnosis of a major affective disorder or schizophrenia.,0
It can be induced by CSA and is totally reversible when the drug is rapidly withdrawn.,0
A within-series phase change design (ABABC) was used to evaluate the effect of video distraction and relaxation in the treatment of a 29-year-old male with anticipatory vomiting associated with cancer chemotherapy.,0
CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.,1
Patient-initiated rapid atrial pacing to manage supraventricular tachycardia.,0
MR images revealed extensive cortical and subcortical white matter brain edema.,0
OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.,1
"Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.",1
Systemic chemotherapy induced complete regression of the soft tissue lesion.,0
"Pneumonitis is emerging as one of the most unpredictable and potentially serious, adverse effects of treatment with MTX.",1
"Although the efficacy of recombinant factor VIIa has been shown in many patients, concerns have arisen about the risk of thrombotic adverse events.",0
Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.,1
"In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.",1
The 3 others developed clinical pericardial tamponade before surgery.,0
"In one patient, karyotypic abnormalities (-5, 7q-) typical of a therapy induced malignancy were associated with rapid progression of a refractory anemia with excess blasts in transformation to an acute non-lymphocytic leukemia.",0
We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia.,1
A review of the literature reveals this as a unique case.,0
Osteonecrosis is not well documented as a predisposing factor of septic arthritis despite such a relationship having obvious clinical significance.,0
"We suggest that sarcoidosis may develop in chronic hepatitis C patients during interferon alpha and/or ribavirin treatment, and diagnostic tests for this adverse effect should be performed during the follow-ups.",1
Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.,1
The results of the comparative study led us to the conclusion that the compression technique is a simple and valuable means of decreasing the side-effects of Adriamycin and increasing tumor response.,0
Only a few reports of overt jaundice are associated with streptokinase.,1
Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.,1
"OBJECTIVE: To evaluate the simple medication regimen, all psychotropics were given at night for patients with chronic schizophrenia, who had been taking them at least twice a day for more than 12 weeks before the entry.",0
These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.,1
The child was treated with resin hemoperfusion (XAD-4) to reduce her serum chloramphenicol concentration.,0
This case report describes two patients with acute obstetric disseminated intravascular coagulation in whom the use of heparin resulted in marked clinical improvement.,0
It occasionally accompanies the heparin-associated thrombocytopenia and thrombosis syndrome.,1
Normal pregnancy after curative multiagent chemotherapy for choriocarcinoma with brain metastases.,0
"A case is presented of a patient who experienced benzodiazepine withdrawal symptoms on discontinuation of nefazodone, an antidepressant that inhibits the cytochrome P450 3A4 isoenzyme.",1
Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate.,1
"Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.",1
Seizures and transient blindness following intravenous pulse methylprednisolone in children with primary glomerulonephritis.,1
"Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.",1
Opioid-related narcosis in a woman with myopathy receiving magnesium.,0
The etiopathogenesis and management of this condition are presented.,0
We report of a 32-year-old man who showed dystonic symptoms within few days after liver transplantation (LT).,0
Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.,1
The patient received the three agents as short infusions over four consecutive days.,0
Use of midodrine (Gutron) to treat permanent hypotension in a chronic hemodialysis patient.,0
"The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome.",1
"We sought to evaluate the etiology of the long QT syndrome in these patients without previously identified causes for QT, prolongation, and determine the prevalence among patients with HIV infection.",0
"Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.",1
Toxic epidermal necrolysis associated with interleukin-2.,1
She recovered with shock therapy and intravenous administration of diphenhydramine and hydrocortisone.,0
"We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.",1
"Therefore, beta-adrenergic agents should be used with great care, especially for patients with myotonic dystrophy, because of these agents' tendency to aggravate or precipitate myotonia and to induce rhabdomyolysis.",0
Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.,1
BACKGROUND: Cytomegalovirus (CMV) infection is a common cause of morbidity and mortality among patients receiving chronic maintenance immunosuppression and is often considered the most important infection in renal transplantation.,0
A 73-year-old woman presented with fever and cough 2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL).,1
Seven of the twelve were treated with beta blockers; 3 of whom suffered cardiac arrest.,0
We describe 4 typical cases from the major fields of rheumatology.,0
"Associated thyreoiditis, myasthenia gravis, thymectomy, Chron's disease, and erythema nodosum: pathogenetic and clinical correlations, immune system involvement, and systemic infectious complications.",0
Fundoscopic examination revealed only hypertensive retinopathy.,0
We report the development of scrotal ulcer in a patient with acute promyleocytic leukemia (APL) within 10 days of treatment with ATRA at a dose of 40 mg orally twice daily.,1
Toxicity associated with barracuda is discussed.,0
Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection?,1
Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.,1
CONCLUSION: This rare therapy-related second malignancy developed after curative larynx-preserving treatment.,0
"Only mild pericellular fibrosis was present in the liver biopsy specimen obtained shortly after abstinence, but after 5 years the second liver biopsy showed that thin septum-like fibrosis that formed portal-to-portal and portal-to-central linkage had developed and ground-glass hepatocytes had emerged extensively.",0
Clofazimine enteropathy caused by crystal deposition can be life-threatening.,1
CONCLUSION: There are only a few confirmed cases of gemcitabine-associated HUS despite the widespread use of the drug.,1
Simultaneous scrofuloderma and intracranial tuberculomas: a rare presentation of systemic tuberculosis.,0
Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung-assessment of clinical implications in patients on combination chemotherapy.,0
A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum.,1
"Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.",1
Cephalosporin-induced leukopenia following rechallenge with cefoxitin.,1
"Abrupt, accidental withdrawal of trihexyphenidyl triggered severe exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties, prompting emergency admission.",1
This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli.,1
Patients with TSHoma-associated autoimmune thyroiditis should undergo careful follow-up for development of Graves' disease after treatment.,0
Failure of blood pressure to increase following erythropoietin therapy in the renoprival status.,0
"Two heroin addicts, aged 34 and 19 years, developed ballistic movements after intravenous heroin overdose.",1
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.,1
It seems that being aware of the undesirable affects of tamoxifen treatment during the chemotherapy and post-chemotherapy period is very important.,0
"A nerve conduction study showed conduction block at the elbow, indicating possible cubital tunnel syndrome.",0
The most common complication of warfarin use is adverse bleeding.,1
"Most interestingly, the evolution of NS paralleled the evolution of cGVHD in all patients.",0
A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment.,1
"The source of fever was never identified, although infection with cytomegalovirus was considered the most likely cause.",0
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
Development of persistent late onset asthma following treatment with captopril.,1
We retrospectively reviewed 16 patients with recurrent/metastatic head and neck cancer who received S-1 monotherapy.,0
"One month after cataract surgery in the right eye, the best-corrected visual acuity was right 6/6 (-1.25) and left 6/10 (-2.00/-0.50 x 100).",0
This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.,1
Cutaneous vasculitis secondary to ramipril.,1
"Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.",1
He was treated and monitored over the subsequent several months.,0
"The authors report five cases of tremor related to itraconazole therapy, which occurred within 1-12 months of initiating treatment and resolved gradually following itraconazole withdrawal.",1
"The pathogenic mechanisms involved in the development of adriamycin cardiomyopathy are reviewed, and the possible synergistic effect of other antitumor antibiotics is discussed.",1
Further biopsy revealed a more severe glomerular lesion.,0
"Second, we report a case of neutropenia, which proved to be fatal in a schizophrenia patient receiving olanzapine and thiazide.",1
"A 52-year-old woman was seen in our outpatient clinic for pain and numbness in the left lower lip and chin, which developed following an endodontic treatment for her mandibular left second premolar.",0
CONCLUSION: A review of the literature shows that this is a particularly uncommon micro-organism.,0
A 53-year-old man developed NMS without rigidity while taking olanzapine.,1
Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.,1
"Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.",1
An adverse reaction to IFN was strongly suspected as the cause of CHF.,1
Cardial and respiratory function was compromised and intubation was necessary.,0
OBJECTIVE: To report the use of oral terbutaline for chronotropic support in a patient who had undergone heart transplantation.,0
This therapy was also complicated by Warfarin-induced skin necrosis.,1
She continued to receive regular insulin 4 times per day over the following 3 years with only occasional hives.,1
We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).,1
A patient developed typical ECM after subcutaneous selfinjection of glatiramer acetate for multiple sclerosis.,1
Successful liver transplantation and treatment of recurrent hepatitis C using pegylated alpha-interferon in a patient with Churg-Strauss disease.,0
We describe two cases that illustrate the use of lithium in the treatment of veterans with PTSD who complained of serious problems with irritability or angry outbursts.,1
Uncontrolled headache induced by oxcarbazepine.,1
"However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.",1
"A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.",1
Life-threatening cranial dystonia following trihexyphenidyl withdrawal.,1
Protein in vitamin K absence (PIVKA) is the prothrombin precursor found in plasma when carboxylation to prothrombin is impaired.,0
"A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.",1
"Surgical resection, when possible, and prolonged treatment with amphotericin provide the most effective form of therapy.",0
"Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.",1
"We suggest that the previous classification of nitrofurantoin induced lung injury into ""acute"" and ""chronic"" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.",1
CONCLUSION: Our case sheds new light on glucocorticoid pancreatotoxicity and confirms the role of macrolides as potential pancreatotoxic drugs.,0
An unusual case of necrotizing fasciitis with extensive soft tissue infection stemming from a prolonged case of osteonecrosis of the jaw presented.,0
Mental illness in mild PKU responds to biopterin.,0
This report supports the findings of others regarding the potential toxicity of topical ester-type local anesthetics.,0
"The risk of developing sAML is estimated to be between 1% and 5%, 2-20 years after exposure to etoposide but may also be related to cumulative drug doses, treatment schedules, host factors and co-administration of other antineoplastic agents.",1
Appropriate treatment for neurosyphilis was instituted.,0
SETTING: Outpatient pain clinic associated with a university hospital.,0
Attempted treatment of factor H deficiency by liver transplantation.,0
We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.,1
"Alone or in combination with corticosteroids, cyclosporine is an effective drug of choice for the resistant patients.",0
"The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.",1
A possible role for a factor with thrombosis-inducing activity (TIA).,0
This report demonstrates that PET scintigraphy might be a helpful tool in the early diagnosis of drug-induced pulmonary toxicity.,0
This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.,1
"Mequitazine seemed to play a part similar to chlorpromazine, and absence of mequitazine-induced photosensitivity may be due to a relatively low dosage of the drug.",1
This is the first report of a disulfiram-like reaction with cefmenoxime.,1
Several authors have speculated bacteraemic patient without having meningitis LP might actually cause meningitis.,0
"Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.",1
"In addition to resuming her opioid therapy, she was treated supportively with bilevel positive airway pressure, diuretic therapy, morphine, aspirin, metoprolol, enalaprilat, intravenous heparin, nitroglycerin infusion, and dopamine infusion.",0
Extra caution should be taken in using octreotide or its long-acting analog in patients otherwise predisposed to intrahepatic bile stasis.,1
"Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.",1
"Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms' tumor.",1
Stanozolol was well tolerated and had minimal side effects.,0
We present a 49-year-old woman with refractory myofascial pain of many years duration who developed subacromial impingement syndrome (SIS) following a series of botulinum toxin injections to the bilateral upper trapezii.,0
Transient phenytoin induced IgA deficiency and permanent IgE increase.,1
We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.,1
Warfarin resistance and enteral feedings.,0
Epstein-Barr virus-associated lymphoma in a child undergoing an autologous stem cell rescue.,0
These findings suggest that bicytopenia in this patient was caused by D-Pen and may be due to different sensitivities in the hematopoietic lineage.,1
We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.,1
Oral hypoglycaemics.,0
"ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.",1
"In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.",1
Ten of these 12 patients also developed severe pulmonary edema.,0
Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.,1
We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.,1
"She was a long-term user of an intra-uterine device (IUD) and, although asymptomatic, had radiological evidence of pelvic infection.",0
"The persistence of free steroid secretion with decreased formation of DS suggests that the o,p'-DDD may have altered sulfatase activity before causing tumor necrosis and total decrease in steroidogenesis.",0
"DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.",1
Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.,1
A 48-year-old woman with a diagnosis of breast carcinoma was treated with adjuvant chemotherapy through a central venous catheter with subcutaneous reservoir (Port-A-Cath).,0
This therapy was ceased in four patients due to neutropenia (22%).,0
Cytomegalovirus (CMV) pneumonia in the setting of non-transplantation patients is a rarity.,0
"CASE REPORT: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda.",1
Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy.,1
"The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.",1
A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.,1
OBJECTIVES: To describe clinical and pathologic findings in patients noted to develop lower gastrointestinal symptoms when exposed to rofecoxib.,1
"Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.",1
One patient required urgent liver transplantation for fulminant hepatic failure after the brief use of black cohosh.,0
Pyridoxine for neonatal seizures: an unexpected danger.,0
1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62 +/- 0.15 mg/day) compared with during the period of high-dose period (mean 1.08 +/- 0.28 mg/day).,1
"However, he had an acute onset of chest pain with fever which happened 4 h after PCI.",0
Human insulin-induced lipoatrophy.,1
This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.,1
This hypersensitivity response cannot be explained pathophysiologically by any mechanism.,0
"More than 15,000 cases have been treated by chemonucleolysis world-wide.",0
"CLINICAL RELEVANCE: Pancreatic neoplasms are associated with a poor prognosis, regardless of treatment modality.",0
Heparin-induced thrombocytopenia is a rare and serious complication of anticoagulation therapy.,1
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of assisted reproduction techniques using in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI).,0
Zidovudine induced pure red cell aplasia: a case report.,1
Substitution of olanzapine with aripiprazole further exacerbated the problem.,0
Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.,1
"We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.",1
"A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.",1
The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.,1
"The histopathologic features of fully developed lesions have been reported; however, early-stage findings have not been previously described, and the histogenesis of this lesion is controversial.",0
Bilateral vocal cord paralysis was seen on laryngoscopy.,0
The cause is presumed to be secondary to hypercoagulability due to asparaginase-induced antithrombin III deficiency.,1
"We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy.",1
DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.,1
"Review of existing literature shows that in immunocompromised patients, GI cryptococcosis invariably coexists with disseminated cryptococcosis, often lacks prominent GI symptomatology, and is primarily diagnosed postmortem.",0
A young woman with epilepsy had tonic-clonic seizures during antineoplastic therapy with adriamycin and cisplatin.,1
DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.,1
The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.,1
Drug-induced pericarditis mimicking Brugada syndrome.,0
"To our knowledge, hyperpigmentation of the skin--and especially of the tongue--has not been reported so far.",0
The serum concentration of AZ was elevated to a maximum of 76.5 mg/ml.,0
"The patient, with a history of cardiovascular disease and glaucoma, was admitted to the hospital because of complaints of shortness of breath, orthopnea, and reduced exercise tolerance.",0
Case management of the anemic patient epoetin alfa: focus on aluminum management.,0
Intrathecal methotrexate-induced acute cerebellar syndrome.,1
"CONCLUSIONS: In our reported case, a local hyperproduction of TNF-alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone.",1
Four hemodialyses with charcoal hemoperfusion were performed over 72 h.,0
"Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure.",0
CASE REPORT: A 44-year-old white man with a 23-year history of undifferentiated schizophrenia and obsessive-compulsive behavior had been treated with clozapine and clomipramine for several years.,0
The patient responded to lamivudine treatment with HBeAg seroconversion and significant regression of fibrosis.,0
We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab.,1
"Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.",1
5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.,1
Pseudomembranous colitis readily occurs in at least certain population groups receiving trimethoprim-sulfamethoxazole.,1
"On day 4, following 3 doses of dalteparin, the patient developed acute respiratory distress attributable to a massive right hemothorax confirmed by computed tomography pulmonary angiography (CTPA) and intercostal drainage of 1500 mL of frank blood.",1
Renal biopsy demonstrated lesions characteristic of rapidly progressive glomerulonephritis with minor interstitial changes.,0
"Coronary thrombolysis is contraindicated in patients with transient cerebral ischemia and stroke, arterial hypertension, cerebral trauma, cerebral aneurysms, and arteriovenous malformations, because of the risk of cerebral hemorrhage.",0
"However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.",1
"A 66 year old HIV infected male heavy smoker presented with arthralgia, myalgia, and weight loss which was originally ascribed to nucleoside induced mitochondrial toxicity.",0
We describe 4 patients with Graves disease who had abnormal increases of serum creatine kinase (CK) concentrations during treatment with antithyroid medications.,0
"RESULTS: Since January 2002, 171 patients with RA have commenced taking leflunomide.",0
"Acutely, SMS decreased acid secretion and restored the BAO/MAO to normal in eight of eight patients.",0
Phenolphthalein-induced toxic epidermal necrolysis.,1
"All had a muscle biopsy, but only one showed the classical rimmed vacuoles.",0
"In a prospective study, we found that 10 of 19 diabetic patients (53%) who had received insulin containing insulin also had high levels of antiprotamine immunoglobulin E.",0
"Unlike most reported cases in which vertebral compromise rarely extends to more than two adjacent vertebrae, our patient had extensive compromise of the thoracic spine.",0
"CONCLUSION: The combination of FSGS with leukemia poses a management challenge to the clinician in terms of further treatment with potentially nephrotoxic drugs, complications of nephrotic syndrome (including infections), and timing of renal transplantation.",0
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.,1
Reversible valproic acid-induced dementia: a case report.,1
"Four months later, she continued to exhibit decreased fluency and dysarthria with ataxia.",0
We present the first case of osteomyelitis in a patient receiving infliximab therapy for severe psoriasis and psoriatic arthritis.,0
Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA).,1
Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.,1
Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.,1
"Ticlopidine is an oral antiplatelet agent frequently utilized in the treatment of cerebrovascular disease and is rarely associated with severe bone marrow suppression, typically aplastic anemia.",1
In one case the patient's reason for attendance was to obtain further supplies of analgesics.,0
"An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.",1
"These results provided consistent evidence that the selective absence of VWFMs with large to medium molecular masses in this patient is caused by the heightened clearance of a complex of IgG inhibitor and VWFMs from the circulation, presumably through IgG binding to the Fc receptor of macrophages.",0
Patient was discharged home on postoperative day 19.,0
"Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).",1
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
Generalized argyria after habitual use of AgNO3.,1
"We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.",1
"We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).",1
We present a patient with human immunodeficiency virus infection under treatment with foscarnet for CMV retinitis who complained of thirst and polyuria.,1
They improved rapidly and over 6 months were able to stop taking analgesics and return to normal activities.,0
"The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.",1
"Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.",1
Nitrogen-oxygen saturation therapy in serious cases of compressed-air decompression sickness.,0
"Serum concentration of cerivastatin at 6 h after taking the last dose (0.15 mg) was 8062.5 ng/L, which was almost 5.7 times higher than that of normal persons.",0
"Case 2 demonstrated after 40 months on chlorambucil the presence of a balanced translocation, t (1;5) (p36;q31) in 90% of the cells.",1
Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed.,1
"Hydroxyurea is a drug widely used to control myeloproliferative disorders, due in part to its relative lack of severe side effects.",0
An objective causality assessment revealed that the interaction was probable.,0
Chemotherapy-induced Raynaud's phenomenon leading to acral gangrene has rarely been reported.,0
Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.,1
The site of thrombosis and the chronological relationship with the IIR implicates a hypersensitivity to infliximab in the causation of the venous thrombosis in this case.,1
Hemodynamic collapse following labetalol administration in preeclampsia.,1
The signs and symptoms were similar to those seen with systemic use of the drug for other ailments.,0
Animal studies are necessary to evaluate this observation and potential disadvantages of hydrocortisone usage.,0
There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.,1
Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.,1
"However, because ADPKD is a bilateral disorder, ACE-inhibitor therapy may worsen renal function, as occurs in patients with bilateral renal artery stenosis.",0
"In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.",1
"This technique has the advantage of being simple, economical and nonallergic.",0
The median interval from initiation of therapy to the development of leukemia is shortened from 54.2 to 41.1 months if radiation therapy is used in addition to chemotherapy.,0
"Appropriate methods for sterilizing endoscopes are reviewed, including sterilization with 2.5 per cent glutaraldehyde solution and ethylene oxide gas.",0
"Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.",1
"We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.",1
"CONCLUSIONS: In our reported case, a local hyperproduction of TNF-alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone.",1
Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.,1
We here report our preliminary clinical experience with caspofungin as an additional drug to the standard trimethoprim-sulfamethoxazole regimen.,0
Complete recovery of the headache symptoms occurred only after OXC was discontinued.,0
We report here the first case using posaconazole for treatment of trichosporonosis in a liver transplant recipient caused by T. mucoides.,0
Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.,1
Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.,1
Secretory endometrial adenocarcinoma in a patient on tamoxifen for breast cancer: a report of a case.,1
Thus catheter-related cutaneous aspergillosis could lead to a severe deep-seated infection in HIV-positive patients.,0
The use of modern multiagent therapy often makes it difficult to appropriately apportion blame for causation of specific side effects.,0
Renal function was restored after withdrawal of enalapril and initiation of steroid therapy.,0
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.,1
Color Doppler imaging of the thyroid gland in a fetus with congenital goiter: a case report.,0
Within one month the corneal ulcer and infiltration disappeared.,0
"Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.",1
"Hepatic Sinusoidal Obstruction Syndrome (HSOS), the new name given to veno-occlusive disease (VOD) of the liver, is a well-known complication of high-dose chemotherapy employed with hematopoietic stem cell transplantation, but it has rarely been observed in children who receive conventional chemotherapy.",0
We report a third case of a 6-week-old infant with Escherichia coli sepsis who received ampicillin and other antibiotics and subsequently developed TEN.,1
"Our aim is to raise awareness of this drug, which is commonly used outside the United States, and to call attention to its well-known and potentially lethal side effect.",0
"Cutaneous bacterial infections, most commonly caused by Pseudomonas aeruginosa, have been clearly linked to use of hot tubs.",0
Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.,1
Acute coronary events following cisplatin-based chemotherapy.,1
"While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.",1
Miconazole a new antifungal agent was used with dramatic response.,0
"A patient taking excessive amounts of an ergot alkaloid for the treatment of migraine headaches developed cool, painful, swollen lower extremities with intermittent claudication and sensory changes.",0
After approximately two weeks of sertraline treatment he noted an intense itching sensation in his scalp after eating a piece of chocolate cake.,1
"Despite cessation of daunomycin, she demonstrated fluctuating systolic function in relation to ATRA administration.",0
"In addition, a 31-year-old man with obsessive-compulsive disorder developed RBD soon after starting fluoxetine therapy, which persisted at PSG study 19 months after fluoxetine discontinuation.",1
RESULTS: The patient developed bilateral central retinal vein occlusions in association with high-dose intravenous immunoglobulins.,0
This report suggests that patients taking bone metabolism regulators may not be able to respond appropriately to hypocalcemic stressors.,0
Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation-- successful treatment with high-dose methylprednisolone and defibrotide.,0
It is common practice in critical care areas for registered nurses to administer antiarrhythmics without a doctor's prescription in life-threatening situations.,0
Splenic hemorrhage: a complication of tissue plasminogen activator treatment.,1
The anemia continued because of bloody stool caused by Crohn's disease.,0
Epsilon-aminocaproic acid and renal complications: case report and review of the literature.,1
Vital signs were within normal limits.,0
Radioisotopic control for baclofen pump catheter failure.,0
Osteonecrosis of the jaw is an uncommon consequence of biphosphonate therapy.,0
We describe a case of delayed onset HIT with resulting massive pulmonary embolism postcardiac surgery that was successfully managed with lepirudin.,0
Resolution of a giant atrial thrombus following anticoagulation therapy.,0
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.,1
Both patients experienced problems due to side effects from the anti-MAC regimen and from an immune-reconstitution syndrome related to HAART.,0
"Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).",1
"Overall, five of the seven patients were rated at least minimally improved in behavioural symptoms.",0
The patient was then treated with sertraline without experiencing any incontinence episodes.,0
Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.,1
Immune tolerance in a haemophilia A patient with high inhibitor using locally prepared lyophilized cryoprecipitate.,0
We describe 2 patients with prior amputation who experienced phantom limb pain (PLP) after receiving paclitaxel therapy.,1
Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.,1
Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.,1
"However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.",1
"This is an endocrine emergency that can lead to respiratory failure, dysrhythmia, and death.",0
"Multiple retinal infiltrates, placoid subretinal lesions, and ground-glass opacity of the retina with hyperemic optic discs were observed in both patients.",0
Another serious complication associated with OHSS is thromboembolic events.,0
Drug-induced eosinophilia is a non-dose-dependent side effect of clozapine.,1
Life-threatening hypokalaemia and quadriparesis in a patient with ureterosigmoidostomy.,0
We report a series of 16 cases of methanol poisoning admitted to our Intensive Care Unit between December 2003 and April 2004.,0
Exposure to the individual compounds was determined by calculating the AUC.,0
This neurocutaneous syndrome consists of angiomatosis of the skin and mucosa as well as the leptomeninges.,0
Magnetic resonance spectra provided a noninvasive means of monitoring CNS response.,0
"CONCLUSIONS: In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.",1
Can roxithromycin and betamethasone induce acute pancreatitis? A case report.,1
The patient subsequently underwent surgery for embolization of the right occipital and superficial temporal arteries and removal of the mass.,0
"To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.",1
The patient was initially treated with hydration and furosemide but developed congestive heart failure.,1
"Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.",1
There is a disagreement regarding imaging studies.,0
These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.,1
Dapsone is increasingly used in the treatment of rheumatic diseases.,0
The patient tolerated the rechallenge with fluorouracil without complications.,0
"We present the case of a patient who had undergone cholecystectomy previously, but in whom morphine given in the Emergency Department precipitated pain consistent with biliary colic; the pain resolved promptly after administration of naloxone.",1
We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.,1
"A punch biopsy showed the presence of KS, whereas a polymerase chain reaction assay documented the presence of human herpes virus type 8 (HHV8) DNA in the skin lesion.",0
Mitomycin C is a powerful antineoplastic agent.,0
Recurrences of hiccups have responded to increases in baclofen dosage.,0
PURPOSE: To present a case of respiratory depression following the administration of nebulised morphine.,1
We should always consider it as a possible late complication and treat it appropriately.,0
The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.,1
Treatment of APL in pregnancy is controversial as the use of ATRA has been questioned due to the teratogenic effect of retinoids.,1
"Magnesium sulfate, a saline laxative, is often used for treatment of intestinal impactions in horses.",0
"Clinical features were those of a cicatricial pemphigoid, with prominent mucosal involvement leading to conjunctival and nasal scarring.",0
"The rapid progression under medical therapy prompted us to replace the thoracic aorta with an 8-mm polytetrafluoroethylene graft, using extracorporeal circulation and core cooling.",0
Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.,1
Medulloblastoma in a patient successfully treated for immature teratoma of the ovary.,0
Pulmonary tuberculosis in a child receiving intensive chemotherapy for acute myeloblastic leukemia.,0
The cornea showed diffuse edema and a stromal ring infiltrate (disciform in appearance).,0
Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies.,0
"The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).",1
"Physicians in the United States, especially those who practice primary care, hematology/oncology, and infectious diseases, must be aware of the availability and use of metamizole in specific patient populations and its potential for harmful side effects.",0
PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.,1
Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.,1
"They are usually localized reactions such as ecchymoses, erythematous plaques, and nodules.",0
"After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.",1
"Vicks VapoRub induces mucin secretion, decreases ciliary beat frequency, and increases tracheal mucus transport in the ferret trachea.",0
Chemoradiation therapy used on pediatric oncology patients often causes dental developmental anomalies that affect future dental care.,0
We present four cases of iatrogenic epidural spinal abscess directly caused by externally introduced catheters or probes.,0
Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis.,1
"He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.",1
"It most commonly occurs in association with hematologic malignancies and appears a few hours to a few days after initiation of specific chemotherapy, as the result from the release of intracellular components into the bloodstream due to abrupt malignant cell death.",0
Accidental intrathecal injection of the wrong drug was suspected and a used ampule of tranexamic acid discovered in the trash can.,0
Stupor from lamotrigine toxicity.,1
Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.,1
Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).,1
Aminophylline hypersensitivity apparently due to ethylenediamine.,1
"Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.",1
The Naranjo probability scale indicated a probable relationship between apnea and exposure to lamotrigine through breast-feeding in this infant.,1
Multiple reports in the last decade have shown increased mortality and increased utilization of resources in patients who received catheterization of the right side of the heart.,0
The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.,1
"However, recurrent staphylococcus aureus sepsis developed during CyA therapy.",1
The mechanism remains unclear.,0
"One of the side-effects of intravitreal triamcinolone is the development of cataract, and it is known that cataract extraction can exacerbate macular degeneration.",1
"Well tolerated, midodrine appears to be a suitable and effective agent as it raises blood pressure significantly via its effect on peripheral alpha-adrenergic receptors.",0
Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.,1
"Three patients were weaned from the VADs, and two survived.",0
"The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.",1
The respiratory rate improved within 5 to 10 minutes of methylene blue administration and continued over a period of 2 hours.,0
Power spectrum analysis of heart rate variability is useful in this instance because it magnifies the trace and detects even minor disturbances.,0
CONCLUSIONS: Blood data did not always reflect marrow status.,0
Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity.,1
"Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued.",0
Pulmonary edema as a delayed complication of ritodrine therapy.,1
A 33-year-old man with advanced testicular cancer underwent high-dose chemotherapy combined with peripheral blood stem cell transplantation.,0
His AFP was initially 9828 microg/L and rapidly dropped to 5597 microg/L in ten days after oral sorafenib treatment.,0
"All patients had typical radiological, magnetic resonance imaging or pathological changes of osteonecrosis involving the femoral heads, while two also had superimposed avascular necrosis involving the humeral heads.",0
"Fludarabine monophosphate, a purine analogue is used in the treatment of lymphoid malignancies.",0
Apomorphine and diphasic dyskinesia.,0
"This is one of the few cases of drug-induced LAD in which the target antigen profile has been characterized, and the first in which the antigen has been shown to correspond to collagen VII.",0
Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.,1
Acute aflatoxicosis: case report.,0
We describe the development of methicillin-resistant Staphylococcus aureus osteomyelitis of the scaphoid in a 49-year-old man from an infection occurring around a catheter in the radial artery.,0
Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.,1
An anovulatory patient was treated with human menopausal gonadotropin and human chorionic gonadotropin.,0
He was admitted to the hospital for treatment after failing to improve on oral ciprofloxacin and inhaled tobramycin.,0
"Both patients with NMS had been treated with neuroleptics, including CYP2D6 substrates.",0
Polymorphic ventricular tachycardia (PVT) is a form of ventricular tachycardia characterized by QRS complexes that seem to change direction during the tachycardia.,0
"Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.",1
Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department.,1
"Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms.",1
These evolutional changes in both proteinuria and glomerular histology suggest a close linkage between the M-CSF treatment and macrophage-related glomerular injury.,1
Secondary pancreatic involvement by diffuse large B-cell lymphoma presenting as acute pancreatitis: treatment and outcome.,0
"BACKGROUND: Bupropion, a novel antidepressant, has been reported to produce fewer adverse effects than the tricyclic antidepressants.",0
"An acquired form of sideroblastic anemia has been described in association with several drugs, especially anti-microbial agents.",0
Suramin has demonstrated modest activity against prostate cancer and is being investigated in clinical trials.,0
"After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.",1
Linezolid is relatively well tolerated and is not believed to be nephrotoxic.,0
"He had an extensive psychiatric history significant for schizophrenia and multiple past hospital admissions, starting at age 14 years.",0
Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-beta without glucocorticoid treatment.,0
"ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.",1
"With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.",1
Use of somatostatin for complications occurring after liver transplantation.,0
A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug.,1
Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.,1
"In these four patients, plasma carbamazepine concentrations after clarithromycin coadministration were approximately twice as high as those after its discontinuation.",0
Successful long-term control with lamivudine against reactivated hepatitis B infection following intensive chemotherapy and autologous peripheral blood stem cell transplantation in non-Hodgkin's lymphoma: experience of 2 cases.,0
There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.,1
"A patient with torsade de pointes risk factors (female sex, advanced age, extreme bradycardia and renal failure) who developed the condition on the fourth day of 400 mg/day of oral moxifloxacin treatment is presented.",0
Three of the 4 patients with hydrocephalus secondary to CNS tumor suffered secondary shunt complications during periods of severe neutropenia resulting from chemotherapy (6 weeks to 6 months after shunt insertion).,0
Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.,1
The bilateral ptosis markedly improved after 7 days of pyridoxine and pyridostigmine treatment and completely resolved after two weeks.,0
"Report of two cases, personal experience and review of the literature.",0
"In 3 of the 5 patients (60%) at 12 months after treatment, plasma cell dyscrasias could not be detected.",0
A child with respiratory distress was found to have been given an antibiotic which was reconstituted with methadone.,0
Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity.,1
Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.,1
"Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.",1
"Despite reduction in the dose of immunosuppression and localized radiotherapy, the tumor had rapidly progressed to involve the soft tissue of the right hand.",0
OBJECTIVE: Omeprazole is one of the most widely prescribed gastric antisecretory drugs.,0
Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.,1
Proteinuria resolved after the initiation of oral prednisolone therapy (1 mg/kg per day).,0
A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.,1
Its etiology has still not yet been fully resolved.,0
We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.,1
Infant twins sustained severe circumoral and pharyngeal burns from a concentrated solution of benzalkonium (Zephiran) chloride prescribed for treatment of candidiasis.,1
We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).,1
"About three weeks into the therapy regimen, he complained of severe retrosternal chest oppression.",0
The catheter was removed after 14 days because a local infection developed that resolved uneventfully with antibiotic therapy.,0
"The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy.",1
Gemcitabine-induced pericardial effusion and tamponade after unblocked cardiac irradiation.,1
"While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.",1
The patient received treatment with dexamethasone 0.2% eyedrops every 2 hours.,0
"The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.",1
Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis.,1
Hepatotoxicity related to itraconazole: report of three cases.,1
We also describe a case of timolol-induced ocular pemphigoid.,1
This association should be considered in the period after vasopressin-treated gastrointestinal hemorrhage.,0
Torsade de pointes during loading with amiodarone.,1
There was no indication that the increase in anaphylactoid reactions was associated with the use of hyperthermia.,0
"Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.",1
A case of disseminated Aspergillus terreus infection in a patient with prolonged neutropenia after stem cell transplant for myeloma is reported.,0
Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure.,1
Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin.,1
OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.,1
This is the first reported case of suspected DIAN due to cefuroxime.,1
The infection was resistant to both high-dose liposomal amphotericin B and voriconazole.,0
He recovered after administration of anti-histamines and steroids.,0
"The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.",1
"In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.",1
Transfusion haemosiderosis inspite of regular use of desferrioxamine: case report.,1
"This therapy was curtailed after three cycles because of nausea, asthenia, and neuropsychological deterioration.",0
The major adverse reactions of antithyroid drugs are hematologic; aplastic anemia (AA) is one of the rarest and most severe complications.,0
"Further study is needed to determine the incidence of subclinical membranous nephropathy in patients with rheumatoid arthritis, and the effect of drugs in triggering clinical manifestations of this condition.",0
"DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.",1
Treatment was initiated with intravenous tobramycin 560 mg daily and piperacillin/tazobactam 4.5 g infused every 6 hours.,0
Necrotizing pancreatitis after transcatheter arterial chemoembolization for hepatocellular carcinoma.,0
"We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.",1
"This case describes a 52-year-old white woman who developed a spontaneous nasal septal perforation after given the antiangiogenic drug, bevacizumab, for metastatic ovarian cancer treatment.",1
"Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.",1
"We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.",1
Metastatic osteomyelitis following BCG vaccination.,1
"Two months later, he was referred to Dhahran Health Center, and admitted with fever, abdominal pain, dysuria, and severe fatigue.",0
We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.,1
"Intravenous mitozantrone was given for 2 years and she is asymptomatic, with computed tomographic evidence of tumour response, 27 months after diagnosis.",0
"SUMMARY OF BACKGROUND DATA: Spinal pain, caused by an infective mass, developed in a 39-year-old man 3 months after an epidural injection for low back pain.",0
Hepatocellular carcinoma in a young woman with prolonged exposure to oral contraceptives.,0
"Liver enzymes returned to normal 4 and 8 weeks, respectively, after riluzole withdrawal.",0
"Endophthalmitis developed in the eye and was treated by pars plana vitrectomy, IOL extraction, and intravitreal antibiotic injection.",0
Thrombolysis with recombinant tissue plasminogen activator is the only established treatment for acute ischemic stroke.,0
"RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.",1
This circular area corresponded to the 3500 microm diameter of the laser spot used in the PDT treatment.,0
The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.,1
"Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.",1
Osteomyelitis occurring during infliximab treatment of severe psoriasis.,1
Deterioration in renal function associated with angiotensin converting enzyme inhibitor therapy is not always reversible.,0
RESULTS: Symptomatic epiphora of the affected eyes was reduced after 2 weeks.,0
"On patch testing, budesonide was strongly positive at day 2 and 3 in a concentration ranging from 1% to 10 p.p.m. (in petrolatum).",0
"Examination revealed severe anterior uveitis with fibrinous exudates in the anterior chamber, flap edema and epithelial bullae.",0
Our institution has also adopted a similar combined therapy protocol for patients with stage III and IV nasopharyngeal cancer and good performance status.,0
Acute graft-versus-host disease of the lung after liver transplantation.,0
Arterial hypertension associated with topical ocular use of phenylephrine in dogs.,1
"Chest x-ray and computed tomography revealed multiple patchy infiltrates in both cases; after several days, these confluent infiltrates developed into pneumatoceles.",0
Radiation recall related to gemcitabine has been reported in lung and breast cancer.,1
"A case of renal artery thrombosis attributable to umbilical artery catheterization, resulting in malignant renovascular hypertension, in a 15-day-old neonate, treated by catheter-directed thrombolysis through the involuting umbilical artery, was studied.",0
Patient A reported right leg weakness (foot drop) during week 4 of CAP-XRT (1600 mg/m2).,1
OBJECTIVE: To report a case of successful outpatient carboplatin desensitization in a pediatric patient with bilateral optic glioma.,0
"Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.",1
"METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.",1
"On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.",1
"Since carbamazepine was discontinued and had been prescribed for bipolar disorder, his olanzapine dosage was increased, and trazodone was added at bedtime for insomnia.",0
Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.,1
Glycerol and urokinase produced rapid resolution of the symptoms and warfarin prevented further recurrence of pseudotumor cerebri for one year.,0
A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.,1
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.,1
"We report a patient with recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption, following successive cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia.",1
Infection and inflammation in patients on dialysis: an underlying contributor to anemia and epoetin alfa hyporesponse.,0
"Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.",1
"We describe a patient who experienced chronic nausea and an episode of confusion while treated with a small, stable dose of oral morphine in the setting of mild renal insufficiency.",1
Her liver displayed reduced volume and there was a mild accumulation of ascitic fluid in the retroperitoneal cavity.,0
Massive vulvar edema complicating tocolysis in a patient with twins.,0
"IFN-beta-1b therapy was then resumed, and the patient is in remission for both nephrotic syndrome and MS.",0
In none of these reports has radiologic or pathologic data been presented.,0
"His fever resolved, but he developed symptoms consistent with those of chloroquine toxicity.",1
This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.,1
CONCLUSION: CBDCA and VP-16 in combination with radiotherapy should be considered an important treatment option for SCEC.,0
Treatment of children with refractory acute lymphocytic leukemia with vincristine and diltiazem.,0
Olanzapine-associated neuroleptic malignant syndrome.,1
"A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.",1
Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).,1
Clinical report of three cases of acute radiation sickness from a (60)Co radiation accident in Henan Province in China.,0
"We described a very atypical case of a high stage, high grade endometrial cancer associated with tamoxifen in a 64-year-old woman with a past history of breast cancer.",1
CONCLUSION: This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal hematoma in this elderly patient.,1
"The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.",1
"In addition, patients with blebitis should be observed closely to identify extension into the vitreous cavity so that intravitreous antibiotics can be administered in a timely fashion.",0
Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report.,1
"Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone.",1
Use of the Naranjo probability scale indicated a highly probable relationship between the observed cardiac toxicity and amphotericin B deoxycholate therapy in this patient.,1
OBJECTIVE: To report a case of severe apnea in an infant exposed to lamotrigine through breast-feeding.,1
Cardiovascular deterioration after seizures in tricyclic overdose has long been suspected.,0
We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.,1
"The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.",1
"CONCLUSION: Since these drugs are used widely in the pediatric transplantation population, this report serves to heighten awareness of this debilitating phenomenon, and to stress the importance of exercising caution when sirolimus and tacrolimus are administered in combination to pediatric patients.",0
"Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.",1
OBJECTIVE: The aim of this study was to introduce a useful diagnostic method to evaluate baclofen pump system-related complications without disturbing the continuous delivery of intrathecal baclofen.,0
Both patients suddenly became hypotensive after injection of chymopapain into a disk.,1
We report the case of a 32-year-old man whose monotherapy with various antipsychotic agents failed.,0
We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).,1
The purpose is to report a complication after photodynamic therapy (PDT) and intravitreal triamcinolone for a presumed choroidal neovascularization in age-related macular degeneration.,0
An unusual course of infection with Mycobacterium malmoense is described in a patient receiving chronic but mild immunosuppressive therapy for rheumatoid arthritis.,0
The relation of TNF-alpha antagonist therapy to demyelinating disease/multiple sclerosis is explored.,0
"Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy.",0
"RESULT: She presented with severe anaemia (PCV of 0.05), White cell and platelet counts were within normal limits and reticulocyte count of 0.001%.",0
A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.,1
The patient was found to have a sigmoidovesical fistula and underwent sigmoidectomy and partial resection of the ileum and urinary bladder.,0
Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.,1
The neovascularization developed within 1 month after the laser anastomosis in all three cases.,0
"We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.",1
"In June 2002, the patient was admitted to the Outpatient Clinic of the Rheumatology Unit for arthralgia affecting the small joints, non-pruritic crops of purple skin lesions and malar rash in the face.",0
The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate.,1
"Histology of a cutaneous lesion showed spongiosis and infiltration of the epidermis by atypical lymphocytes with large hyperchromatic nuclei, perivascular dermal lymphocytic infiltrate (CD3+) mixed with plasma cells and occasional large immunoblasts (CD20+).",0
This is the first case where epoprostenol has been successfully reinstituted.,0
"Dexamethasone levels were measured in the serum by radioimmunoassay and shown to be lowered by o,p'-DDD therapy.",0
Similar occurrences in outpatients reported in the literature are reviewed.,0
Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.,1
The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.,1
"Diagnosis of TTS is one of exclusion as it can mimic many other conditions, and should be considered in patients with unilateral painless ulcerations with a history of trigeminal nerve damage.",0
"Nocardia brain abscess is a rare condition, seen most commonly among immunocompromised patients.",0
We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).,1
His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.,1
"A response to rhEPO was defined as an increase in hematocrit of 4 percentage points or more over baseline, or the elimination of all transfusions with the hematocrit stable at the baseline level.",0
Acute respiratory depression as a complication of nebulised morphine.,1
METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.,1
Herpetic tracheobronchitis.,0
OBJECTIVE: To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain.,0
"Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.",1
Linear IgA bullous dermatosis occurring after carbamazepine.,1
The infiltrate disappeared within 6 weeks.,0
"In these patients, the action of tricyclics can be conceptualized as accelerating rather than counteracting the natural, cyclic course of the illness in all of its phases.",0
"ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.",1
Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).,1
"After removing the methotrexate, administering intramuscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved.",0
"We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.",1
"CASE REPORT: We hereby report a case of radiation recall dermatitis and myositis occurring on gemcitabine monotherapy, five months after completing chemoradiation for locally advanced pancreatic cancer.",1
OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.,1
"The liver damage was probably related to metabolic idiosyncrasy, and was reversible in all patients.",0
Relief by naloxone of morphine-induced spasm of the sphincter of Oddi in a post-cholecystectomy patient.,1
This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.,1
"Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.",1
Trazodone therapy was continued or reinstated shortly after the hypomanic episode without further evidence of hypomania.,0
Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.,1
Acute acoustic nerve palsy associated with vincristine therapy.,1
Hyperthyroidism complicating asthma treatment.,0
The patient was then treated with IL-2 1.8 x 10(6) U/m2 for 5 days per week and 2.5 MU/m2 IFN-alpha three times per week.,0
"Stenotrophomonas maltophilia (previously named Xanthomonas maltophilia) is an aerobic, nonfermentive, Gram-negative bacillus that is widespread in the environment.",0
The asthma resolved within 24 hours following three albuterol inhalations.,0
We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications.,1
The patients were treated with quetiapine as relapse prevention and we followed them up in our outpatient clinic.,0
"Usually, these patients develop hepatitis B surface antigen (HBsAg) seroreversion during the flare.",0
A case study is presented of a licensed practical nurse who developed persistent contact dermatitis.,0
The authors report 9 cases of dystonic reactions in patients with dementia following the initiation of antipsychotic medication.,0
The hearing impairment and tinnitus were gradually reduced after PTU withdrawal and corticosteroid and azathioprine treatment.,1
"On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.",1
Pseudomonas spp. are of increasing importance in human immunodeficiency virus-infected children causing significant morbidity and increased hospitalization.,0
"The subsequent reabsorption of free water from the fluid collection, with the contribution of postoperative hypotonic intravenous fluid administration and possible transient inappropriate antidiuretic hormone (ADH) secretion resulted in acute dilutional hyponatremia and consequent seizures.",0
"On the basis of survival data, it is not clear that use of MTX adversely affected the natural course of their HIV disease.",0
Addition of lithium carbonate resulted in a sustained remission with maintenance treatments.,0
The patient's initial serum calcium concentration was 5.25 mmol/L (21 mg/dL).,0
"DISCUSSION: Itraconazole pulse therapy for onychomycosis appears to be at least as effective as and safer than a continuous treatment regimen, particularly from the perspective of potential liver damage.",0
Diagnosis was made by serial blood glucose determinations during a 20- to 24-hour period after insulin administration.,0
Widespread cutaneous vasculitis associated with diltiazem.,1
Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.,1
Six days after starting acyclovir she exhibited signs of lithium toxicity.,1
"These 4 cases are the first to be recorded in infancy, and with histopathological proof of fat embolism.",0
"Due to the difficulty in identifying and verifying exposures to such agents, only a few chemical compounds are clearly linked to malignancies.",0
Herein is reported an unusual case of coexistent warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for thromboembolic phenomena associated with marantic endocarditis and bronchial adenocarcinoma.,1
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
"Herein, we report a patient treated preoperatively with multiple psychiatric medications who developed serotonin syndrome (SS) during the perioperative period.",0
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
"Elderly patients for whom nitrate has been prescribed should be warned of the occurrence of hypotension, leading to unconsciousness.",1
"All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.",1
All patients experienced an increase in hematocrit level.,0
"After cessation of amantadine, the edema resolved, and the endothelial cell densities were <or=600/mm.",1
Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy.,1
This medicine is available without prescription and contains the potent oxidant ethyl nitrite.,0
"However, glucose-phosphate dehydrogenase was normal in the present case, suggesting that it is not a predisposing condition to the lung injury.",0
Pentazocine-induced fibrous myopathy and localized neuropathy.,1
There are few published reports that discuss oral burns in children.,0
Patients should be informed of the risk of septic arthritis.,0
Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response to carbon dioxide laser therapy.,1
"We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.",1
"Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).",1
Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.,1
Disulfiram-induced fulminant hepatic failure in an active duty soldier.,1
"The rash seen in this patient, who was treated with cephalexin, may be similar to the rash seen with ampicillin treatment of patients with infectious mononucleosis.",1
"We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).",1
The other patient is also in remission and on maintenance treatment for leukemia.,0
Pre-treatment bone biopsy samples contained extensive osteoid covering trabecular surfaces.,0
"This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.",1
Children treated with thalidomide should undergo regular neurophysiologic studies in order to detect presymptomatic or progressive peripheral neuropathy.,0
Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.,1
Refractory hypoglycemia from ciprofloxacin and glyburide interaction.,1
"It is often misdiagnosed as multiple sclerosis (MS) from which it differs in its clinical presentation, course of disease and prognosis.",0
Neuroimaging shows bilateral subcortical and cortical edema with prominent posterior distribution.,0
We conclude that tuberculosis is an important diagnostic consideration for CAPD patients with peritonitis that is refractory to broad-spectrum antibiotics.,0
Endogenous catecholamines in excess are known to cause dilated cardiomyopathy.,0
"The results suggest that the development of severe hypocalcemia can be explained on the basis of hypoparathyroidism in relation to hyperphosphatemia, hypomagnesemia, and acute renal failure.",0
A patient developed optic neuropathy while being treated with isoniazid and ethambutol.,1
DISCUSSION: The pathogenesis of fixed drug eruption and the role of MIF assay in the diagnosis of adverse drug reaction is discussed.,0
"When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.",1
"In a second man the symptoms of prostatism diminished but in the third urinary frequency and nocturia persisted in spite of a reduction in prostatic size, presumably because his symptoms were due to renal insufficiency.",0
Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.,1
"We present a case report of a cytomegalovirus (CMV)-seronegative, 58-year-old male who received a CMV-seropositive donor liver transplant without CMV prophylaxis.",0
Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.,1
Intensive organ supportive measures and intravenous antibiotic therapy led to his gradual recovery.,0
A 66-year-old woman was diagnosed as having pulmonary adenocarcinoma with malignant pleural effusion following investigations for cough and dyspnea.,0
"METHODS AND RESULTS: At 6 weeks after renal transplantation, a 57-year-old woman presented with TMA.",0
Pregancy complicated by acute myeloid leukaemia.,0
Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.,1
Foscarnet is used as therapy of cytomegalovirus (CMV) infection in immunosuppressed subjects.,0
"According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.",1
Optimizing antidiabetic treatment options for patients with type 2 diabetes mellitus and cardiovascular comorbidities.,0
Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient.,1
"The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.",1
"To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.",1
Administration of intravenous gammaglobulin (25 g monthly) allowed discontinuation of steroids without further ophthalmic or neurologic disease.,0
We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.,1
Gemcitabine-induced pericardial effusion and tamponade after unblocked cardiac irradiation.,1
Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.,1
"The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.",1
No severe adverse event occurred during clinical trials.,0
Two probands had borderline mutations; the rest were normal.,0
"We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.",1
"Morphine sulfate in controlled-release tablet form is a relatively new oral preparation being used for the relief of chronic severe pain, such as that related to cancer.",0
Adenocarcinoma of the pancreas developed in a young man who was a 10-year survivor of acute myeloblastic leukemia (AML).,0
Visceral leishmaniasis and macrophagic activation syndrome in a patient with rheumatoid arthritis under treatment with adalimumab.,1
"Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.",1
Possible mechanisms and potential therapies are discussed.,0
"With protein loss in the dialysate and a decreased serum albumin level, the patient developed ankle edema.",0
"The patient recovered from oligoanuria to almost normal renal function, and heart, brain, and musculoskeletal injury was reversible.",0
"Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.",1
Supralethal magnesemia with patient survival.,0
Mucin-producing adenocarcinoma has been extensively studied in relation to this phenomenon.,0
It is well-recognized that flucloxacillin may occasionally result in fatal hepatic injury.,1
"METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.",1
We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.,1
There has been no further recurrence in the long-term follow-up.,0
The study group was composed of four patients who underwent surgery in a 1-year period and experienced chronic pain resulting from superior cluneal nerve injury.,0
We present a case of a patient with long-standing schizophrenia who was treated with clozapine.,0
"Traditional topical measures to reduce local tissue damage, including corticosteroids, sodium bicarbonate, and ice applications, have not consistently demonstrated beneficial effects.",0
Anaphylaxis to cisplatin following nine previous uncomplicated cycles.,1
Red blood cell anemia in a patient with pemphigus vulgaris induced by the use of mycophenolate mofetil and prednisone.,1
"One case presented with Stevens-Johnson syndrome, and the other had systemic papular erythema.",0
PURPOSE: To report a side effect of quinacrine therapy for malaria.,0
Most patients showed some element of dose dependency between antiparkinsonian drugs and the hypersexual behavior.,0
RESULTS: The combination of the two systemic medications resulted in the resolution of the attack with a much more rapid time course than is seen typically for extreme cases of TiACG.,0
"Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.",1
Naproxen-associated sudden sensorineural hearing loss.,1
A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.,1
"Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.",1
"It is essential that perioperative physicians, especially anesthesiologists, understand the risk factors, clinical scenario, and treatment of SS.",0
Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.,1
Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.,1
"Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.",1
The cardiac toxicity of HCQ has focused primarily on acute intoxication.,0
The source of these L. monocytogenes infections was not found.,0
"We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.",1
"Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.",1
These effects were maintained for the remainder of the patient's chemotherapy protocol.,0
"One explanation for the noted increase in the theophylline level is that metabolism occurs mainly by cytochrome P450 (CYP 1A2), an enzyme that is known to be inhibited with high concentrations of zafirlukast.",1
"These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related.",1
Linezolid treatment of prosthetic hip Infections due to methicillin-resistant Staphylococcus aureus (MRSA).,0
"IV propranolol was used as the initial treatment for his hyperadrenergic state, resulting in a decrease in heart rate but a paroxsymal increase in blood pressure.",1
Hypoxia was documented in one case and probably present in the other.,0
A brief review of organophosphate poisoning and the unique features of our case are presented.,0
Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma.,1
"In particular, this adverse effect has never been described with mefloquine (Lariam).",0
We report such a case in a morbidly obese laboring parturient after receiving combined spinal-epidural labor analgesia.,0
"Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.",1
Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.,1
CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.,1
Dexamethasone elevated markedly the levels of an immunoreactive mouse protein(s) which exhibited a Mr (53 kDa) and inducibility consistent with the major Cyp3a product.,0
"Despite the withdrawal of ampicillin and aggressive systemic and wound care, the infant died.",0
"In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.",1
The cases of two asthmatic patients who became hypokalemic after inhalation of normal doses of albuterol are presented.,1
Psoriasis induced by interferon-alpha.,1
We report the case of a 33-year-old man who presented with a large B-cell non Hodgkin's lymphoma presenting as acute pancreatitis.,0
"Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis.",1
"When isolated from the blood and/or the CSF of a patient with a CSF shunt who has symptoms and signs compatible with infection, the organism should not be dismissed as a contaminant.",0
The study was closed early for safety reasons as there were three unexpected treatment-related deaths.,0
"A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",1
Resolution of the symptoms was observed in both patients when interferon alpha was withdrawn.,0
A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.,1
"Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.",1
CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.,1
Nimesulide is a new nonsteroidal anti-inflammatory (NSAID) drug with antipyretic and analgesic properties.,0
We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.,1
"Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.",1
"Spontaneous intracerebral hemorrhage was diagnosed, despite an initial negative CT scan.",0
A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.,1
Cosmetic permanent fillers for soft tissue augmentation: a new contraindication for interferon therapies.,0
This is the first histologically confirmed case of NASH that was aggravated by raloxifene.,1
"Consequently, this is a likely, although rare, possible adverse effect with propafenone for which patients should be monitored.",0
The probability of developing acute leukemia in this study was not significantly correlated to the total cumulative dosage of Treosulfan.,1
Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital.,1
OBJECTIVE: We report a rare case of delayed onset of cerebral infarction caused by an embolism after cervical pedicle screw (CPS) fixation.,0
"CONCLUSION: In patients presenting with pelvic masses and a history of IUD placement, actinomycotic infection should be considered and diagnosis attempted by imaging guided needle biopsy.",0
Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.,1
The data show a strong influence of cortisol on total sleep time and slow wave sleep (SWS) as well as rapid eye movement (REM) sleep.,0
"OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.",1
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).,1
Antitumor activity was observed in four patients.,0
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
"We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.",1
Prothipendylhydrochloride-induced priapism: case report.,1
"It also draws attention to the fact that drug-induced OGC may be a multifaceted disorder with disturbances of movement, thought, behavior, and emotion, reminiscent of the OGC described in association with epidemic encephalitis lethargica.",0
Fixed drug eruption to rofecoxib.,1
"Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.",1
A case of timolol-associated heart failure in a 73-year old white man is reported.,1
"Moreover, the IgG subclasses in glomerular deposits and the presence of chimeric renal cells were studied.",0
CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.,1
"Indometacin is reported to improve growth in Bartter syndrome, but not in Gitelman syndrome, where magnesium supplements are recommended.",0
Case report: mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanisms.,1
A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).,1
Lichen planus and acne provoked by gold.,1
"We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.",1
"At present, no uniformly accepted effective treatment has been described for this condition.",0
"RESULTS: Including our own patient, a total of 26 cases of gemcitabine-associated HUS were identified.",1
Acanthamoeba keratitis.,0
Gold nephropathy.,1
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
There were some temporal periods of good tolerance between these episodes.,0
"Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.",1
Three of the dogs died.,0
Lithium was withdrawn in each case.,0
"By a combination of appropriate selection of medications and an awareness of delirium as a side effect, the patient in the ICU may be treated in a manner to minimize the clouding of consciousness.",0
The purpose of this paper is to illustrate a retrospective case report demonstrating drug extravasation caused by the development of fibrin sheath formation.,0
"Ocular and systemic complications such as eyelid necrosis, central retinal artery occlusion, and adrenal suppression have been reported rarely after corticosteroid injection.",0
"A diagnosis of tuberculous uveitis was established; the patient was treated with rifampin, isoniazid pyrazinamide, and ethambutol and etanercept was stopped.",0
"Between 1988 and 1993, 525 adults underwent OLT.",0
One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.,1
Development of porphyria cutanea tarda after treatment with cyclophosphamide.,1
"Discontinuation of the therapeutic agent led to the amelioration of the clinical profile in all the patients whereas a patient died 40 d after hospital admission due to sepsis, despite acute liver disease improvement.",0
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity.,1
"A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure, had a small-bowel obstruction due to Amphojel concretions.",1
Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.,1
A 31-year-old female was found to have FIGO Stage IIB squamous cell carcinoma of the cervix.,0
The patient described here has had to data 12 years without any oncopathological symptoms.,0
"No gastrointestinal tract or muscular abnormalities were found, and the discomfort was attributed to neuropathic pain.",0
A 34-year-old woman presented to the out-patient clinic with angioedema and type II hereditary angioedema was confirmed immunologically.,0
Probable propafenone-induced transient global amnesia.,1
"Although chronic arterial hypertension is the leading cause of intracranial hemorrhage, an abrupt rise in systemic arterial pressure in normotensive people may sometimes induce a hemorrhagic stroke.",0
Withdrawal of Depakote resulted in resolution of the effusion.,1
"Although studies have shown a relationship between abnormal scapular motion and subacromial impingement, it has been unclear whether the altered scapular biomechanics represent a cause, or consequence, of impingement.",0
"Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.",1
"When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.",1
Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.,1
Both patients had relatively low serum concentrations of immunoreactive EPO.,0
Measurements of protected isolation and selective intestinal decontamination were taken.,0
"With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.",1
"CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.",1
"A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",1
The optimal treatment of IVC thrombosis has not been established to date.,0
Diffuse proliferative glomerulonephritis after bone marrow transplantation.,0
Indium-111 platelet scintigraphy in a patient with chronic disseminated intravascular coagulation.,0
"It appears that specific MEFV mutations are probably not the sole determinants of phenotype, and that unknown environmental factors or modifying genes act as accomplices in this disease.",0
Cardiopulmonary arrest following intravenous phenytoin loading.,1
Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.,1
"The range of previously administered total CBDCA was 2582-9589 mg, and the CBDCA area under the concentration curve of the first treatment exhibited appropriate intensity (mean, 1.92 +/- 0.10; range, 1.76-2.10) in all patients.",0
Thiabendazole is a relatively safe and effective agent with a wide range of activity against nematodes infesting the gastrointestinal tract.,0
"Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.",1
"Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.",1
"Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.",1
Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis.,1
"After discontinuance of infliximab infusions and treatment of symptoms with intermittent courses of prednisone, the patient's arthritis progressively improved, with accompanying decrements in autoantibody titers.",0
She was admitted for observation and all symptoms resolved within 12 h of admission.,0
Only one case of severe symptomatic hepatitis occurring after pulse therapy with itraconazole for onychomycosis and requiring transplantation has been reported previously.,1
Staphylococcus lugdunensis endocarditis following cardiac catheterisation.,0
She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.,1
Carbamazepine-related hyponatremia following cardiopulmonary bypass.,1
"This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.",1
"OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction.",1
DISCUSSION: Propafenone is a class 1C antiarrhythmic agent that blocks fast sodium channels in heart muscle and Purkinje fibers similar to the action of encainide and flecainide.,0
Studies performed 10 years ago on 25 patients with MTX-induced liver cirrhosis indicated that this type of cirrhosis was not of an aggressive nature.,1
The outcome of 19 other children with severe aplastic anemia who received ATG was also summarized.,0
We hypothesize that capecitabine-induced headache is vascular in nature.,1
"We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.",1
Culture was positive for Staphylococcus haemolyticus.,0
"Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.",1
"BACKGROUND: The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common.",1
"However, as with botulinum toxin type A (BTX-A) it has off-label uses, such as for hyperhidrosis, focal dystonias, spasticity, and facial wrinkles.",0
Documentation of cisplatin-related vascular events is important in view of the growing number of patients who undergo cisplatin-based chemotherapy.,0
"After the first oral dose of propranolol, syncope developed together with atrioventricular block.",1
"Treatment with amiodarone was continued; however, therapy with L-thyroxin was initiated, followed by a complete regression of the goiter.",0
Other potential causes of myopathy such as chronic renal failure and other drugs were ruled out.,0
"This case illustrates the importance of screening for parasitic infections before transplantation in the appropriate clinical setting, and demonstrates the utility of direct diagnostic evaluation for parasitic infections in at-risk post-transplant patients with unexplained illnesses.",0
"Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.",1
Mercury is considered a weak sensitiser and contact with mercury salts such as chloride or ammonium chloride may cause hypersensitivity leading to contact dermatitis or Coomb's Type IV hypersensitivity reactions.,0
We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline.,1
No clinical side-effects or evidence of systemic activation of coagulation occurred during the treatment.,0
The clinical course was favorable and the patient achieved full hepatic recovery 3 months after the hepatic failure was detected.,0
L-Asparaginase is commonly used for induction therapy of acute lymphocytic leukemia of childhood.,0
"Because there were no other obvious causes of renal failure in either patient, we propose that skeletal muscle ischemia developed during vasopressin infusion, followed by release of myoglobin and renal damage.",1
"Initially, she was started on Pancrease MT 16, which was subsequently discontinued because fecal fat studies were normal and she seemed to do well on Nutramigen and vitamin supplements.",0
Three nephrotic patients who had reduced renal function and active renal disease with progressive deterioration of renal function prior to the use of MP developed transient renal failure following an MP pulse therapy.,1
"To date, there have been no recorded cases of lichenoid drug eruptions (LDEs) caused by clinical use of the nonsteroidal anti-inflammatory drug salsalate.",0
Thalidomide as elective treatment in persistent erythema multiforme; report of two cases.,0
"Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.",1
Slight involution of the goiter within seven months may be attributed either to colchicine therapy or to treatment with levothyroxine and iodide.,0
INTERVENTION: Escalating dose of tissue plasminogen activator infusion.,0
It was concluded that potassium loss occurred by a non-renal (intestinal) route in phosphate-induced hypokalemia.,1
"CASES: ""A"" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone.",1
Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.,1
Their medical treatment regimens included the use of topical 1% clotrimazole.,0
Better appetite was subjectively noted by 81% of patients.,0
"DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.",1
The eye eventually became blind and painful and was enucleated.,0
"A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.",1
We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.,1
Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.,1
"Fever, pulmonary infiltrates, and pleural effusion following acyclovir therapy for herpes zoster ophthalmicus.",1
"Its use, together with other techniques, such as mycologic, cytologic and histological examinations, allowed us to identify Candida albicans as aetiological agent in this particular case.",0
"We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.",1
Neuroleptic malignant syndrome (NMS) is a potentially fatal adverse reaction to psychopharmacologic treatment.,0
Patient A reported right leg weakness (foot drop) during week 4 of CAP-XRT (1600 mg/m2).,1
We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide.,1
Our case shows that clinical symptoms of polymyositis improved with steroid and immunoglobulin treatment without deterioration of the hepatitis B.,0
"The reactivity of these antibodies, the regulation of the rodent antigens and the identity of the human autoantigen have been investigated.",0
These cases were considered unusual in light of the short delay of their onset after initiation of immunosuppressive therapy and their fulminant course: 3 of these patients died of PCP occurring during the first month of treatment with prednisone.,1
"The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.",1
Further testing at 28 months revealed a serum T4 value of 7.8 micrograms/dl and a serum T3 value of 141 ng/dl.,0
"Even with the low dose of neuraxial drugs commonly administered in combined spinal-epidural labor analgesia, this case underscores the importance of vigilance, frequent monitoring, proper positioning, and rapid resuscitation with escalating doses of ephedrine, atropine, and epinephrine, all of which are essential in the presence of bradycardia or asystole in these patients.",0
"He was not immunocompromised, debilitated and had not had recent surgery.",0
OBJECTIVE: We identified a group of patients with rheumatoid arthritis (RA) who were sensitive to both the beneficial and the side effects of intramuscular (im) gold treatment and whose disease was well controlled with doses of gold between 2 mg every 6 weeks and 5 mg weekly.,0
Panic anxiety after abrupt discontinuation of mianserin.,1
We share our experience in the treatment of candida peritonitis using oral fluconazole.,0
PURPOSE: To report a case of angiographically documented cystoid macula edema occurring after switching a pseudophakic patient from latanoprost to bimatoprost.,1
Initiation of posaconazole led to clinical improvement until the patient's demise from bacteremic vancomycin-resistant enterococcal peritonitis.,1
"A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.",1
"It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.",1
"Although taxol has shown significant activity in advanced ovarian cancer, peripheral neuropathy is likely to become the major dose-limiting toxicity.",1
Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.,1
"She had received cumulative doses of cyclophosphamide 6000 mg, doxorubicin 420 mg, and vincristine 12 mg.",0
"Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.",1
"However, little has been reported about conditions surrounding the change in QT interval after the steady state is achieved that may have implications in the safety and efficacy of the drug.",0
"Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.",1
In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.,1
The patient did well after the operation and returned to normal activity.,0
Localized purpura associated with lamotrigine.,1
CONCLUSIONS: We conclude that a high dose combined with a short infusion time increases the risk of anaphylactoid reactions with the administration of intraperitoneal cisplatin.,1
Propafenone-induced ataxia: report of three cases.,1
"Her serum electrolytes were sodium 122 mEq/L, potassium 5.9 mEq/L, chloride 93 mEq/L, and carbon dioxide 19 mEq/L.",0
"We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).",1
"The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.",1
"They presented with parkinsonism, pyramidal signs, mild cognitive decline, and unresponsiveness to levodopa.",0
Scapular upward rotation is predominantly achieved via a force coupling involving the upper and lower trapezius and the serratus anterior.,0
"At his last visit, 12 months later, his vision had improved and his serum creatinine was lower, at 2.2 mg/dL.",0
A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.,1
"After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.",1
METHODS: We report a case of primary CMV gastritis in a renal transplant recipient.,0
The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.,1
She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.,1
"Disopyramide (Norpace) is a recently released antiarrhythmic agent with quinidine-like actions, but structurally unique.",0
"For this reason, olanzapine was considered strongly associated with this patient's apparent NMS episode.",0
"An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.",1
CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.,1
OBJECTIVE: To report a case of phenolphthalein-induced toxic epidermal necrolysis (TEN) in a patient maintained on several other medications more commonly known to be associated with TEN.,1
Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.,1
"In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.",1
Case vignettes are described.,0
"However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.",1
This helped us to find a proper therapeutic strategy for our patient.,0
However our case report demonstrates that early and aggressive treatment with haemofiltration can improve outcomes even in the presence of severe acidosis.,0
A 39-year-old woman underwent placement of a totally implantable venous access device for chemotherapy to treat a recurrent liposarcoma of the left thigh.,0
Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.,1
"We report a fatal intoxication in a 59-year-old woman who had uremia undergoing hemodialysis, and then took amantadine and pramipexole for Parkinsonian tremor.",0
Clozapine-induced eosinophilia and switch to quetiapine in a patient with chronic schizophrenia with suicidal tendencies.,1
"Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy.",1
"We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.",1
"Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.",1
Our case report suggests that posaconazole is an attractive treatment option in patients with peritoneal dialysis-related Mucor peritonitis.,0
"Interferon-induced psychosis as a ""psychiatric contraindication"" to hepatitis C treatment: a review and case-based discussion.",1
We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.,1
One patient developed irreversible bilateral blindness and another unilateral blindness secondary to optic neuropathy.,0
"Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).",1
"Although, a systemic steroid taper was employed in 10 out of the 14 patients before the development of the skin lesions, the subsequent progression of the skin lesions was not influenced by the use of systemic steroid therapy.",0
"In addition to glomerulonephritis and a butterfly rash, previously negative tests for antinuclear, anti-dsDNA and anti-Sm antibodies became positive.",0
Hypersensitivity reactions to cisplatin following multiple uncomplicated courses: a report on two cases.,1
"Following treatment, that behavior also ceased.",0
"RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.",1
Octreotide administration rapidly reversed hypoglycemia allowing patient stabilization and eventual discharge without any significant adverse events.,0
"The authors describe a case of oral-facial dyskinesia that occurred after discontinuation of amoxapine, and antidepressant which may also have neuroleptic effects.",1
"The increasing use of this agent is expected, because of the increasing number of patients with inflammatory bowel disease.",0
The response of the occlusion of nearly all liver venules underlines the value of anti-inflammatory treatment combined with new thrombolytic medication such as defibrotide for the treatment of severe VOD.,0
One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin.,1
The distinctive histopathological findings led to the correct diagnosis despite sparse clinical information.,0
Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.,1
Surgically induced necrotizing scleritis in a patient with ankylosing spondylitis.,0
"All patients were in a group with an expected mortality rate of 90-100%, based on previous studies.",0
We present the first report of N. exalbida brain abscess in a 63-year-old male patient with follicular lymphoma.,0
The first patient's KI67 level was 2.5% and was positive for the progesterone and estrogen receptor.,0
"Although neurotoxicity is a frequent complication of methotrexate therapy, fatal acute neurotoxicity is extremely uncommon, especially in adults.",1
"METHOD: Onset, course, and outcome of the patient's eye disease were analyzed.",0
A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.,1
"Cardiovascular, pulmonary, and neurologic complications also occur frequently.",0
Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.,1
"Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies.",1
"Based on these data, we conclude that PSL therapy can ameliorate primary nephrotic syndrome in patients over the age of eighty years.",0
"In four of five children who took the drug as scheduled, a cytolytic effect was observed.",0
"A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.",1
"Although guidelines for management have been developed, they may be predicated on data from a single institution or depend on diagnostic procedures and laboratory support that are not necessarily available to physicians in all locations.",0
"A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",1
Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.,1
"We present clinical data, neuropsychological findings, and results of brain computed tomography or magnetic resonance imaging, electroneuromyography, evoked potentials, single photon emission computed tomography, and positron-emission tomography.",0
The management of further bleeding in these patients is difficult.,0
"Signs of ischemia, including mottling of skin and painful extremities, preceded the development of the characteristic electrolyte abnormalities and cardiac arrhythmias.",0
BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.,1
We report on a 64 year old patient with a severe flare-up of UC who responded well to intravenous CyA after a standard therapy with high dose corticosteroids alone had been ineffective.,0
The adrenaline concentration in the left femoral vein was twice as high compared to the right femoral vein.,0
Fixed drug eruption of the scrotum due to methylphenidate.,1
Occlusion of the right brachial and right femoral artery was ascertained by Doppler ultrasound.,0
The fastidious organism grew only on buffered charcoal yeast extract agar and was confirmed as L. micdadei by gene sequence analysis.,0
A case of Kluver-Bucy syndrome associated with delayed cerebral necrosis after radiation therapy and chemotherapy is reported.,0
"CONCLUSIONS: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon alpha administration.",1
"A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.",1
"We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.",1
"Extensive workup for other causes, including infections, was negative.",0
The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.,1
"Adding Dantrolene and Oxybutynin elevated the blood level of Carbamazepine, possibly by inhibition of cytochrome P450.",0
It is activated by cytochrome P450 to form reactive metabolites that bind covalently to DNA to create adducts.,0
Here we report a case of R. equi-associated pulmonary abscess in a renal transplant recipient successfully treated with a combination of carbapenem and teicoplanin.,0
Phantom limb pain as a manifestation of paclitaxel neurotoxicity.,1
"It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called ""3-week sulphasalazine syndrome"", a rare, but often fatal, immunoallergic reaction to sulphasalazine.",1
The second patient exhibited sudden PLMS following olanzapine injection.,1
"Specifically, the data from our American series are insufficient to evaluate the hypothesis that the M694V/M694V genotype confers a more severe phenotype, or increases the risk of amyloidosis; but both our data and the recent literature (160) indicate that amyloidosis can occur in FMF patients with only 1 copy, or no copies, of the M694V mutation.",0
"Because of her severe symptoms, mifepristone was administered for a period of 19 days.",0
"The patient had been free of interstitial pneumonitis for 14 months, but died of pneumothorax.",0
The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.,1
"Those reporting SCs significantly more often reported weight gain than those reporting TSCs, with oral problems and appetite loss significantly less common in the SC group.",0
Rhabdomyolysis associated with clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes.,1
We present four cases in which the use of heparin was associated with hyperkalemia and discuss the pathophysiology.,1
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
"We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug.",1
PURPOSE: To report a case of traumatic flap dehiscence and Enterobacter keratitis 34 months after LASIK.,1
"The thrombi were treated with successive intravenous fibrinolysis under transesophageal echocardiographic guidance, without complication.",0
"Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.",1
"We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.",1
"Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.",1
"Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly.",1
Eleven were seropositive and 2 had Felty's syndrome.,0
"CONCLUSIONS: Although budesonide may be beneficial because of its anti-inflammatory effects, clinicians should be alert to its potential for causing contact dermatitis.",1
Tardive oculogyric crisis during treatment with clozapine: report of three cases.,1
"Bronchospasm did not recur, making it unlikely that tartrazine hypersensitivity caused this problem.",0
"Human chorionic gonadotrophin, administered exogenously as well as produced endogenously during pregnancy, is responsible for the onset of OHSS, and high levels of estradiol appear to worsen the condition.",0
"In the presented case fluvoxamine-induced akathisia in an OCD patient was partially resistant to the anticholinergic agent biperiden, and was successfully treated with the 5-HT2A/5-HT2C antagonist mianserin.",1
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.,1
Loss of seizure control associated with generic substitution of carbamazepine.,0
"RESULTS: In a 22-year-old Thai woman with Graves' disease, tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo developed after 3 years of therapy with PTU.",1
We report a case of contact dermatitis due to sodium bisulfite in Tathion eye drops.,1
Alprazolam withdrawal delirium unresponsive to diazepam: case report.,1
"METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",1
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
"A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.",1
STUDY DESIGN: Case reports are presented of three premature infants (mean gestational age 27 weeks) cared for in the intensive care nursery in whom clinically significant septal hypertrophy and left ventricular outflow tract obstruction developed during dexamethasone treatment for bronchopulmonary dysplasia.,1
OBJECTIVE: To report the late development of immune-mediated diabetes mellitus after completion of alfa-interferon therapy for hepatitis C in an Asian patient.,1
"After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.",1
"This ""fibroelastic form"" would represent the acute or subacute phase of constriction.",0
"We suggest that the sagittal sinus thrombosis in this patient was caused by acquired, transient free protein S deficiency.",0
We reevaluated his cardiac parameters.,0
A lupus-like syndrome associated with infliximab therapy.,1
Neuroleptic malignant syndrome and severe thrombocytopenia: case report and literature review.,0
Antibiotic treatment did not stop the progress of the disease.,0
"However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.",1
"We present the case of a patient who had undergone cholecystectomy previously, but in whom morphine given in the Emergency Department precipitated pain consistent with biliary colic; the pain resolved promptly after administration of naloxone.",1
An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.,1
We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.,1
Bilateral blindness after starting highly active antiretroviral treatment in a patient with HIV infection and cryptococcal meningitis.,0
"Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.",1
"The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.",1
Cyclophosphamide can rarely cause interstitial pneumonitis and fibrosis.,1
Cardiac toxicity related to BCNU has not been described well.,1
CONCLUSIONS: VVR stimulates mucin secretion and MCTV in the LPS-inflamed ferret airway.,0
We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.,1
Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.,1
"We present a case of HUS in an advanced ovarian cancer patient treated with carboplatin and gemcitabine, and described its favorable outcome after chemotherapy interruption and supportive care with a 1 year follow-up.",1
"The tryptase sera level was 109 mg/L one hour after the reaction had subsided, while the basal values were normal.",0
Patients were vaccinated with BCG (Moreau strain) between 17 days and 4 months of age.,0
"CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",1
Medical or surgical therapy is variably successful in these men.,0
"Acetazolamide (AZ) is mostly excreted in the urine, therefore, the blood levels of AZ often tend to increase in patients with chronic renal failure.",0
It is concluded that hypoparathyroid patients being treated with vitamin D and calcium should be carefully monitored in the case of an intercurrent illness or a change in medication.,0
"We now describe a case in which local catheter directed thrombolysis, via a peripherally inserted central catheter (PICC), was used to treat a large thrombus surrounding the tip of an indwelling central venous line that was causing superior vena cava obstruction (SVCO), in a patient with cystic fibrosis.",0
It was not detected either on FA or ICGA with the conventional camera.,0
Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome.,1
"Hyperinfection, an augmentation of the normal skin-lung-intestine life cycle, occurs in roughly two-thirds of infected transplant recipients, with dissemination in the remainder.",0
"When rechallenged with the same drug 6 months later, he developed hypothyroidism.",0
Treatment with sodium bicarbonate readily corrected a potentially life-threatening cardiac arrhythmia and is therefore suggested to be imperative in the treatment of these cases.,0
"CASE REPORT: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda.",1
We report a case of severe respiratory failure due to gold salt toxicity in a patient suffering from rheumatoid arthritis requiring mechanical ventilation.,1
"Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.",1
The reaction to sodium sulfite in the next patch testing was negative.,0
"Other pertinent laboratory data, including liver and renal function tests results, serology for virus infection, and serum levels of vitamin B12 and folic acids, were normal.",0
Hypotension and sinus arrest with nifedipine in pulmonary hypertension.,1
The authors report a case of a patient who received alteplase for acute myocardial infarction and developed spontaneous subfascial hematoma without any evidence of direct trauma.,1
Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.,1
We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences.,1
L-asparaginase-provoked seizures as singular expression of central nervous toxicity.,1
CONCLUSIONS: We report the first case of gemcitabine-induced LABD.,1
"To the authors' knowledge, this is the first case report of the successful treatment of disseminated cutaneous phaeohyphomycosis in a dog.",0
"The infant died despite intensive resuscitative efforts, including the use of digoxin-specific Fab antibodies.",0
This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine.,1
This case is the eleventh to report this condition.,0
Fluoxetine-induced akathisia: clinical and theoretical implications.,1
"Moreover, she had changed her antiperspirant 1 week before the onset of the lesions.",0
"Case presentation, management, and etiology are discussed.",0
Recent data in animal studies have indicated that olanzapine and clozapine rapidly impair whole-body insulin sensitivity in a dose-dependent manner.,0
"By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.",1
"To our knowledge, this is the first report of t-MDS associated with ATL.",0
We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.,1
"MATERIALS AND METHODS: Between March 1997 and December 2001 at our Department of Musculoskeletal Oncology, 231 patients with peripheral osteosarcoma received a central venous catheter to allow infusion therapy and blood sampling.",0
"Although the literature on the use of risperidone in elderly patients with dementia consists largely of uncontrolled trials, case reports, and chart reviews, it appears that this agent is effective for managing agitation in this population and does so with a low frequency of extrapyramidal symptoms (EPS).",1
Transrectal ultrasound-guided needle biopsy of the prostate is a widely accepted technique to obtain prostatic tissue for histological examination.,0
Case studies of three patients with SCs and the 8% of survey participants with SCs only are in focus.,0
We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.,1
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).,1
The course of delirium due to lithium intoxication.,1
"Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.",1
"A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.",1
"PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.",1
METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.,1
We will also discuss other potential mechanisms inducing this disturbance and its differential diagnoses.,0
"RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.",1
The scavenging properties of N-AC may palliate and possibly prevent free radical-mediated liver damage.,0
"Although the treatment of S. aureus endocarditis in immunosuppressed transplant patients has traditionally resulted in loss of their allograft, prompt diagnosis and appropriate antibiotics with continued immunosuppressive therapy resulted in a successful outcome and allograft preservation in this case.",0
We present a patient with documented pacemaker related left-sided endocarditis associated with an acute embolic stroke who was treated with antibiotics with complete recovery and its two-year follow up.,0
"A patient is described with a 25-year history of disabling, and at times life-threatening, anorexia nervosa alternating with major depression associated with suicidal ideation.",0
He became completely premorbid 2 weeks after administration of levodopa.,0
"Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.",1
Local aprotinin injections are used in the treatment of chronic tendinopathy.,0
The daily doses ranged from 0.5 to 3 mg.,0
"CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.",1
RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.,1
Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.,1
A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.,1
"In this phase I study 37 patients received 97 courses of KW-2149 administered as an i.v. bolus injection every 21 days at sequential dose levels: 5, 10, 17, 25, 35, 47, 60, 75, 90 and 100 mg/m2.",0
"We describe two cases of late postpartum hemorrhage following Cesarean section, attributed to pelvic arterial pseudoaneurysm, that were successfully treated by direct thrombin injection under ultrasound guidance.",0
"At 26 weeks' gestation, she was transferred to our center.",0
A healthy 42 yr-old woman presented with a left keratitis which she had had for 3 months.,0
"After exclusion of common reasons of this condition, liver biopsy was performed.",0
Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.,1
Persistent triamcinolone acetonide particles on the posterior lens capsule after intravitreal injection.,0
We describe a child aged 11 years who ingested large amounts of plastic material used for knitting chairs and charpoys.,0
A case report of a patient with probable cisplatin and bleomycin-induced TMA is presented.,1
PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.,1
"Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.",1
"Radiation therapy decreased the size of the mass, but five months later partial small bowel obstruction occurred because of recurrent lymphomatous infiltration.",0
Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.,1
Celiac disease diagnosis was performed and symptoms and laboratory abnormalities improved after gluten-free diet.,0
There have been only two reports of cimetidine-induced hepatitis.,1
Fulminant liver failure associated with clarithromycin.,1
All patients showed marked aphasia and other cognitive deficits.,0
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.,1
RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.,1
"Ideally, the ostium is treated by positioning the stent with a slight degree of overhang in the aorta to ensure coverage of the aorto-ostial junction.",0
Posthypoglycemic hyperglycemia (rebound hyperglycemia) after overdosing of insulin was diagnosed in 6 cats with diabetes mellitus.,1
Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.,1
"Nevertheless, symptomatic CH has been reported in association with various underlying diseases.",0
Nabumetone-associated interstitial nephritis.,1
Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.,1
"In all 5 patients the need for oral corticosteroid therapy was substantially decreased or eliminated, thus decreasing potential corticosteroid-induced morbidity.",0
All the patients recovered after an appropriate treatment for 83 days.,0
"We report one case of pregnancy-onset severe diffuse proliferative nephritis in a patient with systemic lupus erythematosus (SLE), who was successfully treated with a combination of anti-tumour necrosis factor (TNF)-alpha, plasmapheresis and high-dose intravenous gammaglobulin.",0
"CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.",1
"Later, confirmatory urine testing of both patients using high-performance liquid chromatography was negative for tricyclic antidepressants.",0
There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.,1
"The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.",1
"To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.",1
"Thrombosis of the left main coronary artery complicating percutaneous transluminal coronary angioplasty has, to our knowledge, not previously been reported.",0
Abdominal wall metastases from ovarian cancer after laparoscopy.,0
METHODS: We present a case of intraoperative erection after the initiation of continuous spinal anesthesia that was treated with intravenous glycopyrrolate.,0
"This approach could be discussed in a multidisciplinary setting in similar cases, especially due to the described negligible recurrence rate after successful initial thrombosis after treating femoral pseudoaneurysms, pseudoaneurysms of the pancreatic artery, or even endoleaks after stenting of aneurysms of the aorta.",0
"During the three years of follow-up, both pulmonary sarcoidosis and hepatitis C have not recurred.",0
A patient with the Wolff-Parkinson-White syndrome presented with incessant orthodromic atrioventricular tachycardia following initiation of procainamide therapy.,1
"Subsequently he had severe hyperphosphatemia (29.3 and 14.1 mg/dl; 9.46 and 4.55 mmol/L), hypocalcemia, hyperuricemia, hyperkalemia, and azotemia.",0
Bone injury while undergoing electro-convulsive therapy is thought to be rare.,0
Tonic status epilepticus presenting as confusional state.,0
"The most common findings are fever, malaise, headache, and exacerbation of cutaneous lesions.",0
"A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer who was treated with adjuvant tamoxifen.",1
"We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.",1
"We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain.",1
"In these patients, long-acting octreotide may trigger serious hypoglycemia.",1
The resulting pneumonitis may be severe and irreversible.,0
A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.,1
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).,1
"By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.",1
"Hiccupping caused by gastric distention, spicy foods, and neural dysfunction often resolves itself without any treatment.",0
"Cardiac glycosides are thought to prevent doxorubicin cardiomyopathy by competitively inhibiting doxorubicin at its receptor sites, but ouabain has a much shorter half life than doxorubicin and its metabolites and so is less effective than digoxin.",1
"The diagnosis is confirmed by cytology, tissue studies, and viral cultures.",0
Cardiac arrest associated with sulprostone use during caesarean section.,1
A review of the literature was carried out with special reference to the significance of clinical myopathy with a negative biopsy.,0
An unusual case of Ecstasy poisoning.,1
"Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.",1
Drug withdrawal resulted in a slow and progressive reduction in bilirubin levels and liver enzymes.,0
"A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.",1
"Careful clinical and hematological monitoring should be performed, especially for the first 3 months, in patients beginning treatment with Pentasa.",0
Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion occurred in a postmenopausal patient on tamoxifen therapy 5 years after mastectomy for breast carcinoma.,1
The authors suggest that serum sodium levels be carried out before commencement of carbamazepine and caution be used in prescribing carbamazepine to patients with low or borderline low sodium values.,0
Trihexyphenidyl and isoprinosine in the treatment of subacute sclerosing panencephalitis.,0
Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma.,1
Effect of a GnRH analogue (leuprolide) on benign prostatic hypertrophy.,0
CASE SUMMARY: A 25-year-old postpartum white woman developed multiple watery stools and abdominal cramping on day 6 of therapy with clindamycin vaginal cream for bacterial vaginosis.,1
Acute renal failure in a child associated with acyclovir.,1
"We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.",1
Imatinib mesylate-related fatal acute hepatic failure in a patient with chronic myeloid leukaemia and chronic hepatitis B infection.,1
"Carbonic anhydrase inhibitors used in the treatment of glaucoma, seizure disorders, and hypertension are rarely associated with blood dyscrasias.",0
A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea.,1
In recent years there has been an increase in the use of ACE inhibitors in the paediatric population.,0
We report a patient with inoperable pancreatic cancer who developed gastrointestinal bleeding secondary to radiation-recall related to gemcitabine and review literature.,1
Patients with metastatic breast carcinoma and similar presentations should be considered for prophylactic therapy with allopurinol and hydration before chemotherapy.,0
"Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.",1
"These findings are consistent with recent in vitro literature, which implicate a series of neuroleptic medications with mitochondrial dysfunction.",0
"DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",1
"The serum creatinine and blood urea nitrogen concentrations were 2.7 mg/dl and 70 mg/dl, respectively.",0
The disorder recurred during treatment with paclitaxel.,0
"Intestinal wall thickness, evaluated by ultrasound, is an important prognostic factor which could act as a guide to surgical indication.",0
We present an AIDS patient with severe and prolonged lactic acidosis on stavudine and lamivudine.,1
Afterwards the thrombocyte count continuously decreased to normal values.,0
"The mainstay of therapy has been potassium replacement, however, recent evidence suggests propranolol is a more effective therapy.",0
Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.,1
"In nine cases of botulism B infection due to food poisoning acute onset of accommodation paresis, mydriasis, and dry-eye symptoms were the prominent clinical findings.",0
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
We describe a patient in whom noncardiogenic pulmonary edema developed during intrabiliary infusion of monooctanoin.,1
Blood level monitoring helps to determine the therapeutic and toxic ranges for anticonvulsants and antidepressants.,0
Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).,1
This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.,1
"However, both the exacerbation of inflammatory bowel disease and de novo inflammatory bowel disease after orthotopic liver transplant (despite sufficient allograft immunosuppressive therapy) have been described.",0
We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab.,1
"A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",1
Agranulocytosis during clozapine therapy.,1
"Hereditary angio-oedema is rare and potentially life-threatening, being characterised by recurrent episodes of perioral or laryngeal oedema.",0
Early ritonavir-induced maculopapular eruption.,1
"Histological analysis of a lung biopsy showed a diffuse infiltration with pigmented macrophages without granulomas, which particularly involved the pulmonary arterial and venular walls.",0
Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?,1
We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.,1
Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.,1
"The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.",1
"Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.",1
"Cyclosporine is a potent inhibitor of simvastatin metabolism, and may therefore facilitate simvastatin-induced rhabdomyolysis.",1
"However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.",1
The patient subsequently developed progressive worsening of her vision and presented to our ED with bilateral visual loss.,0
Erythropoietin is beneficial in mitomycin-induced hemolytic-uremic syndrome.,1
METHODS: The central and peripheral fields were examined with the Humphrey Visual Field Analyzer.,0
"Its use in reproductive age women has become increasingly common in recent years, intensifying the risk of fetal exposure.",0
"Hiccups can arise from idiopathic, psychogenic and organic causes.",0
The most common clinical presentation is fever secondary to a central line infection.,0
A further case of anaphylactoid reaction to methylprednisolone is reported.,1
All 4 patients who were recruited completed the procedure successfully without significant difficulty.,0
"Vapreotide was found to reduce nausea and vomiting considerably, by inhibiting the release and action of gastrointestinal hormones and the secretory and motor functions of stomach and intestines.",0
Physicians should be aware that PLP can occur after initiation of paclitaxel.,1
"Propionibacterium avidum is a Gram-positive, nonsporulating, facultative anaerobe that has a low level of virulence and is rarely pathogenic.",0
Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.,1
OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.,1
"An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.",1
"Five and one-half years after the diagnosis of myeloma, while in remission on cyclophosphamide therapy, the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma.",1
"Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.",1
Our patient is doing well and is continuing life-long anticoagulant therapy.,0
Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.,1
The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.,1
SMS treatment arrested progression of tumor growth only in patients in whom there was a reduction in gastrin and gastric acid secretion.,0
She had been receiving oral colchicine therapy for mixed connective tissue disease.,0
Education of employees and physicians should result in the prevention of unnecessary tissue destruction and pain for those inadvertently exposed to hydrofluoric acid.,0
"After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.",1
Patch testing with NSAIDs is useful for confirming clinical diagnoses of delayed hypersensitivity to these drugs.,0
The lamellar inflammation was refractory to topical steroids and only resolved when pressure was controlled.,0
Restless legs syndrome and periodic limb movements during sleep probably associated with olanzapine.,1
Review of the literature and report of a case following irradiation and cytostatic therapy.,0
"The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.",1
"Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.",1
PURPOSE: To review the current literature on suspected green tea-related hepatic reactions and to describe two new cases reported within the framework of the Italian surveillance system of natural health products.,0
We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.,1
"Although some of these agents can improve cardiovascular disease risk in patients with diabetes, others may increase the risk and may be prohibited from use in certain populations.",0
"We present a case of disseminated histoplasmosis, complicated by retroperitoneal bleeding and leading to death, in a patient who was receiving systemic immunosuppressive therapy for rheumatoid arthritis and who was enrolled in a gene-therapy trial.",0
To characterize the relationship between TPO levels and platelet counts in this setting we serially measured both parameters over the entire treatment period of patients receiving multicycle polychemotherapy.,0
"Both patients subsequently developed markedly elevated EBV-DNA titers in association with monoclonal, light chain-restricted B cell populations in the blood.",0
"In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics.",1
We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.,1
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
"At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.",1
"After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.",1
"We review the literature concerning an increasingly reported and interesting adverse effect, atypical antipsychotic-induced obsessive-compulsive symptoms (OCS).",0
NEH occurs most frequently in patients receiving chemotherapy for haematologic malignancies.,0
We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.,1
Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.,1
"The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.",1
Central serous chorioretinopathy associated with inhaled or intranasal corticosteroids.,0
Life-threatening interstitial lung disease associated with trastuzumab: case report.,1
"The conglomerate of plastic threads, entrapped food material and other debris, formed a huge mass occupying the whole stomach.",0
We report on a case associated with atenolol.,0
"However, each infant demonstrated hemodynamic decompensation shortly after verapamil administration and required cardiopulmonary resuscitation.",1
Azathioprine can cause severe myelosuppression.,1
An association between NCPH and patients infected with human immunodeficiency virus (HIV) has been reported.,0
"Up to now, however, its healing effect on bronchiectasis has never been demonstrated.",0
We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman.,1
"One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.",1
Adjustments in his drug regimen led to the discovery of pseudoparkinsonism and other extrapyramidal symptoms.,0
The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.,1
A diagnosis of masked theophylline poisoning should be considered in similar situations involving a rapid decrease of insulin requirements.,1
Metabolic acidosis induced by acetazolamide.,1
"A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.",1
"It is currently undergoing evaluation as an adjunct to bone marrow transplantation but its use in patients with metabolic disorders, such as Hurler's syndrome (HS), has not been explored.",0
Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit.,1
"A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.",1
We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.,1
She also had been treated with oral conjugated equine estrogen (Premarin) because of congenital pituitary dysfunction.,0
We describe a case of extensive thromboembolism associated with antithrombin (AT) deficiency complicated by thrombocytopenia which resolved when low-molecular-weight heparin was instituted.,0
Reactions to Aquaphor: is bisabolol the culprit?,0
"The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.",1
"RESULTS: In a 22-year-old Thai woman with Graves' disease, tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo developed after 3 years of therapy with PTU.",1
Hypernatraemia induced by sodium polystyrene sulphonate (Kayexalate) in two extremely low birth weight newborns.,1
Acute lymphoblastic leukemia as a second malignant neoplasm in a child with medulloblastoma.,0
Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.,1
Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain.,0
"The authors present a case study of a mentally healthy man who repeatedly experienced short-lived, obsessional-like suicidal ideas and images after ingestion of the anti-fungal drug ketoconazole.",1
We report a case of vitiligo that occurred during the second month of interferon alpha 2a therapy for chronic active hepatitis C.,1
Acute generalized exanthematous pustulosis induced by nimesulide.,1
"A possible mechanism for this alarming outcome is discussed, and it is suggested that resuscitation facilities should be quickly available during such trials.",0
Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.,1
We describe a patient who developed granulocytopenia and fever after taking dipyrone and discuss the available literature.,1
With this initial therapy we have had no treatment failures.,0
"Nine months later, she remains asymptomatic and shows no evidence of pulmonary decompensation.",0
Angioedema and dysphagia caused by contact allergy to inhaled budesonide.,1
We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.,1
"Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA.",0
"Pathologically only a subpopulation of malignant cells responded to the chemotherapy, demonstrating viability of the majority of the tumor, with cell death only in the subpopulation.",0
She was then placed on 1-month recall for the next 4 months.,0
"Spironolactone was continued, as serum creatinine and potassium levels were initially normal.",0
Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.,1
Livedo reticularis associated with interferon alpha therapy in two melanoma patients.,1
Five cases are presented that demonstrate the effectiveness of diazepam and its close relative clorazepate in controlling this problem.,0
The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.,1
"CASE SUMMARY: A 57-year-old female with cardiomyopathy and ""sulfa"" (trimethoprim/sulfamethoxazole) allergy documented as pancreatitis presented with symptoms consistent with pancreatitis after use of furosemide.",1
We report here two patients who underwent T cell-depleted mismatched-related stem cell transplantation for hematologic malignancies and required aggressive post-transplant immunosuppression for graft-versus host disease (GVHD).,0
"CASE SUMMARIES: In each case, the patients were treated over 5 years with lovastatin and developed rhabdomyolysis that coincided with the completion of a prescribed regimen of a newer macrolide antibiotic.",1
"If this patient would have died suddenly without the laboratory investigations that lead to the diagnosis of myeloblastic leukemia, the cause would have been probably and wrongfully allotted to treatment with olanzapine.",0
"In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.",1
Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.,1
"RESULTS: The response rate was 84.6%, with complete response in one patient and partial response (PR) in 10 patients.",0
METHODS: We present a case in a 71-year-old man who underwent an operation for CPS fixation and laminoplasty for cervical spondylomyelopathy.,0
Blood cultures were positive for Agrobacterium yellow group.,0
"Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).",1
"After recovery, the children tolerated continued chemotherapy without any decrease in the doses of drugs.",0
We describe a case of PRES in a patient with collapsing focal glomeruloesclerosis (collapsing FGS) with complete recovery after withdrawal of cyclosporine (CSA).,1
CASE DESCRIPTION: We have observed severe infusion reactions accompanied by a loss of consciousness in two patients.,0
Isoniazid and ethambutol as a cause of optic neuropathy.,1
A short review on imatinib-related hepatotoxicity is also presented.,1
"Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years.",1
Restless legs syndrome and periodic limb movements during sleep probably associated with olanzapine.,1
"The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.",1
"After an uneventful tonsillectomy and extubation, stridor and respiratory distress developed.",0
"Infliximab is a chimeric tumor necrosis factor-alpha (TNF-alpha) monoclonal antibody, which has been used extensively in patients with rheumatoid arthritis and inflammatory bowel disease.",0
"Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.",1
"In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.",1
The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.,1
A 57-year-old white male with unresectable pancreatic cancer received capecitabine in combination with radiation therapy followed by capecitabine alone given over approximately a 3-month time period.,0
Two patients who developed cholestatic liver disease after exposure to antibiotics are described.,0
Persistent ashen-gray maculae and freckles induced by long-term PUVA treatment.,0
Reversible renal failure associated with angiotensin-converting enzyme inhibitors in polycystic kidney disease.,0
His thigh was indeed in close contact with his trousers pocket where he used to store a wiping rag drenched into white spirit and cellulosic thinner.,0
Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.,1
We report here three patients with hematologic malignancies and one patient with metastatic carcinoma with chemotherapy-induced leukoencephalopathy.,0
The authors propose that differential involvement of dopamine systems may account for the transition from akathisia to tardive dyskinesia.,0
"Two underwent shunt revision for proximal obstruction, with an intact distal system.",0
"On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.",1
"We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.",1
"A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.",1
"In addition, growth failure was documented beginning at approximately 8 years; bone age was delayed and stimulated GH peaks after clonidine and arginine were 2.2 and 9.2 microg/l, respectively.",0
"The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.",1
"Hypertension was treated with acepromazine maleate (0.001 to 0.005 mg/kg of body weight) i.v., decreasing arterial pressures to reference values.",0
"In these two patients, five of six treated tumors decreased in size, and three completely responded.",0
"Mycophenolate mofetil is a non-nephrotoxic alternative which should be considered to rescue cyclosporine-dependent, severe myasthenia gravis sufferers with renal impairment from progression to end-stage renal failure.",0
Gaucher's disease (GD) is an autosomal recessive lysosomal storage disease resulting in an abnormal accumulation of glucocerebrosides in macrophages.,0
Ciprofloxacin-induced renal insufficiency in cystic fibrosis.,1
A 54-year-old female was admitted to our hospital for gingival bleeding and was diagnosed as acute promyelocytic leukemia (APL).,0
We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment.,1
"Abrupt, accidental withdrawal of trihexyphenidyl triggered severe exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties, prompting emergency admission.",1
"Acute pancreatitis is a known, although rare, complication of mesalamine treatment.",1
The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.,1
CONCLUSION: A 26-year-old man with bipolar disorder developed hyperammonemia three weeks after initiating carbamazepine therapy.,1
We conclude that one should be cautious when treating patients with systemic lupus erythematosus and pre-existing renal disease with cyclosporine A especially when tubulointerstitial abnormalities are present and/or other nephrotoxic drugs are used.,0
"CASE REPORT: A 29-year-old black man, HIV-infected since 1996, began highly active antiretroviral therapy (HAART) with zidovudine, lamivudine, and indinavir.",0
"Until the frequency of this adverse reaction is clearer, it would seem advisable to ensure that plasma HDL cholesterol is documented before and rechecked after commencement of thiazolidinedione therapy.",0
"Hormonal, ultrasonographic, radioiodine scanning and fine needle aspiration findings were consistent with the diagnosis of Hashimoto's thyroiditis.",0
The authors report 2 cases of renal damage associated with lithium carbonate treatment.,1
"Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.",1
"We conclude that, though rare, E. avium can be pathogenic in humans and that E. avium bacteremia is associated with gastrointestinal abnormalities.",0
Diagnosis and management of such infections in the immunosuppressed host are difficult.,0
"Drug induced renal failure is a serious, potentially, fatal illness that is preventable.",0
The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.,1
A diffuse intrahepatic metastasis of a carcinoid was treated with a loco-regional intraarterial chemotherapy via a catheter system implanted in the gastroduodenal artery.,0
"CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.",1
"After administration of Oxybutynin concomitantly with an increase in the dose of Dantrolene, she presented the clinical symptoms and laboratory finding of Carbamazepine intoxication.",1
Liver biopsies taken while symptomatic showed portal fibrosis progressing to cirrhosis.,0
A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.,1
"A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.",1
"We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).",1
OBJECTIVES: To describe the clinicopathologic features of 3 patients with CML who rapidly progressed from chronic phase to blast crisis while taking imatinib and to perform a review of the literature.,1
Two patients had ampicillin-associated seizures.,1
Drug eruption associated with sulfonamide treatment of vertebral osteomyelitis in a dog.,0
"We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.",1
Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.,1
PURPOSE: To report a case of Serratia Marcescens corneal ulcer as a complication of orthokeratology treatment.,0
Anisocoria from transdermal scopolamine.,1
Acute pleuropericarditis after coronary stenting: a case report.,0
Methotrexate-induced diffuse interstitial pulmonary fibrosis.,1
Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.,1
Five of the patients received no radiotherapy.,0
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.,1
"Cranial magnetic resonance imaging showed widespread, abnormally high signal intensity in the deep white matter in both patients, though one patient had normal cranial computed tomographic scan.",0
Topiramate is a new anticonvulsant drug recommended for treatment of partial and generalized seizures in children and adults.,0
"Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.",1
An associated finding included a 2+ positive antinuclear antibody test with a titer of 1:320.,0
We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.,1
Analysis of the PCR products revealed sequences sharing close homology with the coxsackie B-like group of enteroviruses.,0
Both patients presented as self-referrals to the emergency department.,0
Tracheobronchial obstruction was ruled out by investigation with a fiberoptic bronchoscope.,0
Common hair care practices are a frequent cause of alopecia in black women.,0
The presence of a myopathy could render this patient susceptible to the respiratory effects of opioids.,0
"Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.",1
"Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.",1
"No guidelines exist for calculating doses by either actual or ideal weight, and the calculated doses may vary by as much as 25%.",0
"If unrecognized, the neurologic deterioration becomes irreversible and may result in death.",0
"CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.",1
"He wore a retainer lens, rigid gas permeable lens, overnight for 2 months before the corneal ulcer occurred.",0
Elevation of serum creatine kinase during treatment with antithyroid drugs in patients with hyperthyroidism due to Graves disease.,0
This case demonstrated the importance of obtaining complete drug histories from patients.,0
We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.,1
"All-trans-retinoic acid (ATRA) has been proved to be an effective treatment for acute promyelocytic leukemia (APL), inducing remission in more than 90% of cases.",0
"Here, we report the successful treatment of a colonic ulcer that had penetrated the urinary bladder.",0
Risperidone-induced tardive dyskinesia.,1
"BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.",1
A case report and review of the literature.,0
Streptokinase is the mainstream therapy for acute myocardial infarction.,0
"METHODS: A 54-year-old healthy male underwent uneventful bilateral LASIK for the correction of myopia and astigmatism (-5.75 -3.00 x 20 degrees right eye, -5.50 -3.00 x 170 degrees left eye).",0
Report of three patients.,0
"A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.",1
"A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.",1
An intertriginous eruption with histological features of epidermal dysmaturation and an interface dermatitis has been previously reported in the dermatopathology literature.,0
"Periodic alternating nystagmus generally implies structural brainstem disease, especially at the craniocervical junction.",0
"Range orders should, for example, take into consideration the patient's age, pain intensity, and comorbidities; avoid frequency ranges; and prescribe a maximum dose that is at least two times but no more than four times the minimum dose in the range.",0
"After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.",1
"A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.",1
Reversible cardiomyopathy caused by administration of interferon alpha.,1
Acute renal failure during lisinopril and losartan therapy for proteinuria.,1
"The administration of ""sweet spirits of nitre"" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.",1
Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.,1
Pentamidine is one of two agents currently used to treat infections with Pneumocystis carinii.,0
Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity.,0
Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.,1
Acute reversible ataxo-myoclonic encephalopathy with flecainide therapy.,1
"She purchased cosmetic contact lenses via the Internet, and followed a contact lens care system irregularly, occasionally using tap water.",0
"The patient's response to the combination of clonazepam and baclofen suggests that the pathophysiology of the ""painful legs and moving toes"" may be linked to impairment of spinal serotonergic and GABA functions.",0
Tigecycline-induced acute pancreatitis: case report and literature review.,1
We report a case of hyponatremia associated with a grand mal seizure in a 28 month-old child after intra-nasal desmopressin administration for high fluid intake with nocturnal enuresis.,1
"Findings of electrophysiologic study and cardiac magnetic resonance imaging were within normal limits, pointing to the ingestion of Aconitum as the most likely source of his arrhythmia.",0
We describe a case of infection with Mycobacterium abscessus in a 67-year-old woman receiving infliximab as a component of her therapy for RA.,1
"OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.",1
"BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.",1
"A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.",1
Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?,1
"Focal glomerulonephritis and interstitial nephritis in methicillin-treated, heroin-related infective endocarditis.",1
"CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.",1
"This translocation determines a fusion gene, bcr-abl, which encodes a constitutively active protein, tyrosine kinase, resulting in decreased apoptosis, defective adhesion, and genomic instability in transformed cells.",0
"The tumor initially had responded well to chemotherapy; however, while the tumor mass decreased, plasma and urine catecholamines and the blood pressure increased.",0
The treatment of FMF attacks in patients who cannot use colchicine is an important problem.,0
In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.,1
"PURPOSE: The intravitreal application of triamcinolone acetonide as treatment of long-standing, therapy-resistant cystoid macular edema after penetrating keratoplasty is reported.",0
"Metformin is described as a glucose-lowering agent for treatment of type 2 diabetes mellitus and as antiobesity drug, though results achieved with this last indication are not conclusive.",0
"Two patients with severe dialysis osteomalacia, whose fractures and deformities had become progressively worse over 3 years, were treated with desferrioxamine (DFO).",0
The 3-week sulphasalazine syndrome strikes again.,1
Like other atypical neuroleptics olanzapine is considered to show a reduced prevalence of extrapyramidal side effects when compared to classical neuroleptic drugs.,1
Coagulopathy associated with the use of cephalosporin or moxalactam antibiotics in acute and chronic renal failure.,1
CONCLUSIONS: Any patient undergoing medical treatment for tuberculosis requires proper education concerning potential drug side effects.,0
It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.,1
"Consequently, inadvertent placement of the needle into the vertebral artery, thyroid, neural tissues, or esophagus can occur with the fluoroscopic or blind approach.",0
Ritonavir should be added to the list of drugs that can induce adverse cutaneous reactions in HIV patients.,1
We describe a woman who received polyacrylamide gel injections for cosmetic reasons and developed a severe granulomatous inflammation paranasally.,0
"Only two case reports of adults with allergic contact dermatitis to this chemical exist in the literature, and we describe three more cases of children with recalcitrant atopic dermatitis found to have potential allergic contact dermatitis to bisabolol- a component of the Aquaphor emollient they were using to treat their atopic dermatitis.",1
Hypotension and sinus arrest with nifedipine in pulmonary hypertension.,1
Cytomegalovirus infection is a potentially fatal complication of treatment induced immunosuppression in patients with inflammatory bowel disease.,0
A 59-year-old female was admitted to Tsukuba University Hospital and diagnosed as IgA-lambda multiple myeloma (stage IIIA).,0
Serotonin syndrome caused by interaction between citalopram and fentanyl.,1
Endocrine physicians should be alert to this in patients with fixed DI and an abnormal thirst threshold.,0
All patients recovered without sequels 3 to 6 months afterward.,0
"The importance of differentiation between primary and ""therapy-linked"" disease, and the difficulties in making such a distinction, are discussed.",0
Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.,1
"Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.",1
METHODS: Retrospective case series of six eyes of three patients that developed Acanthamoeba keratitis with Synergeyes hybrid contact lens wear.,0
The low frequency HAR wave persisted for the subsequent 3 months until a tingling sensation returned to the left leg.,0
"Rush oral desensitization with Viokase solution was attempted, starting with 5 mg, and the dose was doubled every 20 minutes, aiming to reach a cumulative dose of 700 mg.",0
"However, because only a small proportion of the baclofen penetrates into the central nervous system when administered orally, we tested whether it is possible to increase the efficacy of treatment by continuous intrathecal infusion of baclofen (CITB) in a patient with severe tardive axial dystonia unresponsive to conventional therapy.",0
"We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.",1
Hepatic angiosarcoma associated with androgenic-anabolic steroids.,0
Renal injury due to anastrozole has not been published in the English literature.,1
"The diagnosis was confirmed by liver biopsy, antimitochondrial antibody, muscle biopsy, and electromyography.",0
"Quinapril is an angiotensin-converting enzyme inhibitor (ACE-inhibitor) and overdose can lead to prolonged hypotension and, less frequently, transient renal impairment.",1
Bronchial anthracostenosis with mediastinal fibrosis associated with long-term wood-smoke exposure.,0
"This case suggests that, when TMP/SMX is combined with glipizide, patients should be closely monitored, especially those at high risk for hypoglycemia.",0
Endotracheal intubation eventually was performed.,0
"The clinical manifestations of an anaphylactoid reaction are identical to true anaphylaxis; however, a previous exposure to the offending agent is not needed to manifest these symptoms.",0
"Moreover, the presented cases serve as a link in a spectrum of hepatic disorders recently recognised to be caused by environmental agents such as vinyl chloride, arsenic, and thorotrast, and by contraceptive and anabolic steroids.",0
Scleroderma in association with the use of bleomycin: a report of 3 cases.,1
"Another trial of slower desensitization was done using Pancrease MT 16 (1 capsule: 16 000 U of lipase, 48 000 U of amylase, and 48 000 U of protease), starting with 1/4 capsule per day, with increments of 1/4 capsule every 3 days, until an entire capsule was reached by day 10, then increased by approximately 1/2 capsule every 4 days until reaching the therapeutic dose of 1 capsule with each meal by day 25.",0
This resulted in loss of seizure control and a decrease in his serum carbamazepine concentration from 12.4 to 6.7 micrograms/mL.,0
"A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.",1
A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.,1
"OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.",1
The diagnosis of pseudomembranous colitis was made by flexible sigmoidoscopy and a positive stool specimen for Clostridium difficile toxin.,0
"Porcine factor VIII (pFVIII), which is used to control bleeding in patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII, is not known to increase the risk of arterial or venous thrombosis.",0
"After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.",1
We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.,1
"Although the literature on the use of risperidone in elderly patients with dementia consists largely of uncontrolled trials, case reports, and chart reviews, it appears that this agent is effective for managing agitation in this population and does so with a low frequency of extrapyramidal symptoms (EPS).",1
Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.,1
Immunohistochemistry confirmed some pigment-containing cells to be macrophages.,0
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
Three other patients with clinically determined ULD showed a variable response and some notable side effects during treatment with NAC.,0
"In the absence of a congenital long QT syndrome, torsades is seen with certain drugs such as antiarrhythmic agents (Class IA, IC, III), psychotropic medications, antidepressants, antihistamines, and electrolyte disturbances.",0
"Over the next 4 months, there was progressive corneal stromal thinning and descemetocele formation in 1 eye, requiring application of cyanoacrylate glue, and stromal edema and scarring in the other eye, which resulted in a visual acuity of counting fingers.",0
"However, it has not been reported as a cause of peritonitis.",0
"We report a patient with recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption, following successive cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia.",1
"Histologic examination of the excised specimen showed chronic granulomatous inflammation, and subsequent microbiologic studies cultured an acid- and alcohol-fast bacillus that was later identified as Mycobacterium fortuitum.",0
Spontaneous splenic infarction associated with sumatriptan use.,1
Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.,1
Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.,1
"Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.",1
Hypokalemia after normal doses of neubulized albuterol (salbutamol).,1
"The patient experienced over a 10-month period, signs and symptoms suggestive of metabolic toxicity marked by bouts of gastrointestinal distress, low-grade fever, incoordination, and disorientation.",0
"In our case, the seeding might have been related to the type of needle used and the multiple passes required to treat the liver lesion.",0
The average length of clinical follow-up was 6 months (range 1-13 months).,0
"BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.",1
"On the basis of the clinico-radiologic presentation, a pulmonary hemorrhage was likely to occur; so to clarify the origin of this process, a complete serologic examination was performed but all the antibodies were negative.",0
Patient 1 presented bilateral ballism 1 week after intravenous heroin injection.,1
METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.,1
"Forty patients with HCM were treated with calcium-channel blockers such as nifedipine, diltiazem, and verapamil.",0
METHODS: The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and retinae.,0
Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.,1
Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.,1
"Therefore, physicians and dentists alike must understand how to identify and prevent these adverse effects in order to further improve HIV patient treatments.",0
Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal.,1
The rate of infection in patients who require ventricular assist devices is estimated at more than 35%.,0
CONCLUSION: This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal hematoma in this elderly patient.,1
"CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxifen may not reduce of developing endometrial lesions, including carcinoma.",1
"Although a continuous intravenous infusion of dobutamine was maintained, therapy with oral terbutaline 2.5 mg every 6 hours was initiated.",0
These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.,1
The cases of CBZ-induced SLE reported in the literature were reviewed.,1
The objective of this paper is to report 5 cases of rhabdomyolysis (RML) in patients with acute leukemia (AL).,0
The association of hepatitis B virus infection and vasculitis or other immune-mediated manifestations is well documented.,0
Embolic phenomena occurred in 10 (42%) of 24 cases.,0
Current literature related to the presented case and the ongoing debate regarding repeated prescriptions are considered in this study.,0
We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.,1
CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient.,1
"We report a case of a 60-year-old woman affected by squamous lung carcinoma, who developed paroxysmal supraventricular tachycardia during cisplatin and etoposide combination chemotherapy.",1
Dapsone-induced erythroderma with Beau's lines.,1
Only one patient reported transient side effects.,0
Polymyositis masquerading as mitochondrial toxicity.,0
A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.,1
"Although vasculitis has been reported in the course of hairy cell leukaemia, it has only rarely been reported as the consequence of cladribine treatment.",1
"It can be caused by infection of the donor or by contamination of the organ during harvest, preservation and handling, or at transplantation.",0
His anxiety proneness along with a dysphoric response to the neuroleptic were deemed responsible for these attacks.,0
"There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.",1
"We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.",1
"Despite a complete molecular response, it is currently recommended to continue these targeted therapies to avoid relapse.",0
Diagnostic and interventional percutaneous coronary catheterization is associated with stroke.,0
The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.,1
"DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.",1
Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.,1
"The aetiology is currently unknown, and treatment difficult, with a poor response to antihistamines.",0
Upper gastrointestinal haemorrhage is a serious complication of aspirin and clopidogrel (dual) anti-platelet therapy with a high morbidity and mortality.,1
"One patient suffered coronary artery vasospasm, attributed to the use of topical 1:1000 epinephrine during surgery.",1
Management of liver failure in a haemophilic patient co-infected with human immunodeficiency and hepatitis C viruses.,0
"Amiodarone was discontinued, and thyrotoxicosis gradually abated.",1
Fatal chickenpox in a patient with nephrotic syndrome.,0
"After the chlorambucil was discontinued, the wbc count began to slowly rise and the patient developed clinical AML.",1
"She was diagnosed to have pulmonary sarcoidosis at stage II, and the combination treatment was discontinued.",0
"A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",1
Viral antigen was not detected at the end of or during 3 of the 5 treatment courses and decreased to a low level following the 2 other courses.,0
Histopathological studies from specimens taken by transbronchial biopsy showed bronchiolitis obliterans with fibrosing alveolitis.,0
Orbital cellulitis after faden operation on the medial rectus.,0
We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.,1
He did not have pneumonia.,0
L-asparaginase-induced pancreatitis has been reported during or closely following administration of the drug.,1
"From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).",1
BACKGROUND: Sympathomimetic-related intracerebral hemorrhage is well-documented.,0
"After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes.",1
"EBV-associated post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication following solid organ transplantation and hematopoietic stem cell transplantation (HSCT) using bone marrow or peripheral blood as stem cell sources, but rarely reported in umbilical cord blood transplantation (UCBT).",0
"Perilymphatic atrophy can be a complication of intralesional corticosteroid injections given for the treatment of conditions such as psoriasis, alopecia areata, and keloids, and intraarticular corticosteroid injections given in diseases such as rheumatoid arthritis.",0
It is indicated in many inflammatory skin conditions characterized by polymorphonuclear cell infiltration.,0
We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.,1
Only papers published in English were reviewed.,0
Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.,1
"Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.",1
We report a case of exfoliative dermatitis clearly linked to intravenous and intraperitoneal administration of tobramycin.,1
An antibiotic lock technique was created using a flush solution of vancomycin 1 mg/ml with 100 unit heparin/ml.,0
"In the instances that it does occur, previous liver disease or failure to be abstinent from alcohol are thought to be causative.",0
Post-influenza vaccine chronic inflammatory demyelinating polyneuropathy.,0
"After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.",1
"During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.",1
"Management of the hypertension required large doses of antihypertensive agents, including sodium nitroprusside, for six postoperative days.",0
We report the first case of a 54-year-old Turkish woman who presented with ceftriaxone-induced FDE.,1
Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.,1
"Cardiac time intervals of a fetus in labor can be presented, which did not change significantly throughout the first stage of labor.",0
Nephrotic syndrome associated with lithium therapy.,1
Hyperbaric oxygen therapy for cerebral palsy: two complications of treatment.,0
Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation.,1
"MAIN OUTCOME MEASURES: The infants were monitored by serial measurements of basal serum cortisol concentrations, responses to the Synacthen stimulation test, measurement of growth and of weight gain, and, in one case, more detailed anthropometric measures of body composition.",0
Effects of the methylprednisolone pulse therapy on renal function.,0
METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine.,1
"Although the role of antipsychotics in this situation is speculative, development of rhabdomyolysis related to hyponatremia and/or its correction should not be underestimated and should be assessed thoroughly.",0
"The patient recovered completely from his liver injury, but the sicca complex persisted 1 yr after the drug was given.",0
The analysed carbachol concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260.,0
"The side effects of MMF, such as bone marrow toxicity, have been reported.",1
Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.,1
CONCLUSION: Close monitoring for severe skin reactions is in order when using leflunomide.,0
Mycophenolate mofetil may be considered as a useful alternative in the treatment of severe myasthenia gravis when standard therapeutic regimens fail.,0
We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.,1
"In this report and other reports describing successful resuscitation, the total dose of sodium bicarbonate is conspicuously higher than in reports describing extracorporeal interventions.",0
Diagnosis of hypothyroidism during treatment can be difficult because of the common side effects of alpha interferon.,1
A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction.,1
The evolution was favourable without treatment.,0
A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.,1
Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).,0
Aspirin is one of the world's most commonly used medications and its use benefits many diverse conditions.,0
This treatment has the potential to cause severe vision loss as a result of intractable corticosteroid-induced glaucoma.,1
Pulmonary fibrosis is a severe complication associated with bis-chloronitrosourea (BCNU) therapy.,1
"Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.",1
Cholesterol-lowering agents have been demonstrated to decrease hepatic lipids in Niemann-Pick type C patients.,0
The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.,1
Sirolimus (rapamycin) and everolimus are immunosuppressive agents that inhibit cardiac allograft vasculopathy.,0
"Ankylosing spondylitis was present in two patients, but no other extraintestinal manifestations developed.",0
"Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.",1
"In two neonates with antral hyperplasia, the cessation of therapy lessened the gastric-outlet obstruction.",0
Physicians must consider this when prescribing these medications for patients with misdirected eyelashes.,0
"Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.",1
"He was hospitalized for 51 days and, after aggressive diuresis and discontinuation of pioglitazone, was discharged with a weight loss of 30 pounds.",0
"We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.",1
"We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.",1
"The diagnosis of this entity is difficult, if not misdiagnosed, because of its rarity and its subacute presentation.",0
OBJECTIVE: To report a case of toxin-positive Clostridium difficile-induced colitis (CDIC) after use of clindamycin phosphate vaginal cream.,1
An unusual case of psoas abscess complicating one of the earliest performed ileo-anal pouch anastomoses is reported.,0
"Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.",1
Acute valproate ingestion induces symptomatic methemoglobinemia.,1
The diagnosis of acute myocarditis with an eosinophilic infiltrate was established as the cause of death.,0
"Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy.",1
In case of relapse the clinically important question of discontinuation of lithium versus the concurrent use of ECT and lithium may arise.,0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
Esophageal spasm following propranolol overdose relieved by glucagon.,1
"Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.",1
"Two days after surgery, signs of orbital cellulitis developed in his right orbit.",0
"One initially received diethylstilbene followed by estradiol, 80 mg monthly, and finally estramustin, 140 mg twice daily.",0
"We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.",1
"We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.",1
"Postoperatively, the first two patients treated with 1 to 2 cc of thrombin were slow to awaken; one had evidence of vasospasm by transcranial Doppler ultrasound studies and multiple infarcts on cranial computerized tomography, while the other had a moderate-sized frontal hematoma with intracranial hypertension.",1
"Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.",1
A case report and review of the literature.,0
Late-onset donor-to-host transmission of Candida glabrata following corneal transplantation.,0
Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.,1
This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.,1
The patient had a history of environmental allergies.,0
Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.,1
Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.,1
We report a case of portopulmonary hypertension in which the pulmonary hypertension resolved after initial orthotopic liver transplantation.,0
Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.,1
"The detection rates were fluoxetine, 48.8% (20/41); tricyclics, 5.8% (3/52); RBD, 4.3% (3/70); objectively normal sleepers, 3.3% (1/30); PLM, ST/SW, 0% (0/82).",0
She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.,1
A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.,1
"Although a direct causal relationship between immunosuppression and lymphomatoid granulomatosis is lacking, the association of the two has been described.",0
"Arteriography demonstrated extensive pruning of the distal arterial tree along with bilateral external iliac artery dissections - a finding that is not often associated with young, normotensive patients with chronic ergot toxicity.",0
"2-Chlordeoxyadenosine (2-CdA) is an antineoplastic/immunosuppressive agent used to treat hairy cell leukemia (HCL), chronic lymphocytic leukemia, and low-grade lymphomas.",0
There was only a short term exposure to classic antipsychotics prior to risperidone administration.,0
Sulfasalazine has been associated with bronchopulmonary complications of inflammatory bowel disease (IBD) in adults.,1
Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.,1
Linear IgA bullous dermatosis responsive to a gluten-free diet.,0
"By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.",1
Approximately 80% of akinetic-rigid syndromes are due to Parkinson's disease.,0
"We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.",1
"The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.",1
"CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.",1
Nocardia is a serious opportunistic infection in renal transplant recipients and nocardial brain abscess in these patients has a high mortality.,0
Dipyrone-induced granulocytopenia: a case for awareness.,1
Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.,1
"Because OK-432 (penicillin-treated and heat-treated lyophilized powder by a substrain of Streptococcus pyogenes A) was expected to be effective for immunosuppression, we tried its topical injection.",0
"Cryptococcus neoformans has been reported to be isolated from blood cultures in around 20% of patients with cryptococcosis, and cryptococcemia has been correlated with poor prognosis.",0
Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.,1
"CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.",1
"However, there can be a delay in diagnosing porphyria and a difficulty in selecting safe medicine for it even today.",0
Potential predisposing factors.,0
"CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.",1
"However, to our knowledge, there are no accurate estimates of the incidence of CNV in other retinal vascular diseases, such as diabetic retinopathy.",0
"Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.",1
Losartan-induced angioedema.,1
"Retrospective reanalysis of the radiation therapy technique, with emphasis on the doses received by the optic pathway structures, was performed.",0
"Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.",1
"Two patients were found to have a positive ANA at low titers, 1 of whom had histopathologic evidence of stratum malgiphian necrosis with perivascular lymphocytic infiltration on skin biopsy.",0
"The total number of nucleated cells infused was 0.8 x 108/kg, with CD34+ cells 1.8 x 106/kg and CFU-GM 1 x 104/kg.",0
This article reports the cases of two patients in whom a widespread dermatophyte infection mimicked the cutaneous lesions of their underlying collagen vascular disease.,0
"DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.",1
"Although the immediate postoperative course was uncomplicated, delayed onset of abdominal pain and fever lead to the diagnosis of superior mesenteric and portal vein thrombosis.",0
"On December 5, 1995, he began therapy with recombinant IFN-alpha at a dose of 3 MIU three times a week.",0
"Because of its unusual appearance, the name serpentine supravenous fluorouracil hyperpigmentation is suggested for this entity.",0
Influence of physiologic hormonal modification and of hormonal treatment in a patient with a history of migraine with aura.,0
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.,1
"Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning.",1
We report the first case of tuberculous uveitis due to etanercept.,1
Our patient presents one copy of the most common mutation (CYP2C19*2) affecting the activity of the isoenzyme and probably another rare or private mutation.,0
"Although tardive dyskinesia is a known adverse reaction of sustained treatment with traditional neuroleptic agents, it was only rarely reported in association with sulpiride, a selective D2-receptor antagonist.",1
INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.,1
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
Rituximab (chimeric anti-CD20 IgG1 monoclonal antibody) is effective in the treatment of relapsed/refractory low-grade lymphomas of B-cell origin as well as in diffuse large B-cell lymphoma.,0
Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.,1
Toxic encephalopathy related to antihistamine-barbiturate antiemetic medication.,0
Two reports of spindle coma are noted with alcohol and imipramine.,1
OBJECTIVE: We report a case of cutaneous KS lesions in a patient affected by CML treated with imatinib.,1
Hepatitis C (HCV) treatment using interferon-alpha (IFN-alpha) and ribavirin is recommended in HIV/HCV co-infected patients to prevent liver cirrhosis and liver-related death.,0
"Bilateral ear infections, central nervous system lymphoma and infection, or other drug-induced neuropathies were excluded as possible etiologies for the deafness.",0
Two days' administration of levomepromazine 100 mg led him to a coma for 2 days.,0
Hypercalcemia in an AIDS patient treated with growth hormone.,1
"Different reasons for the RPE atrophy such as collateral damage of the choriocapillaris with a subsequent secondary RPE atrophy, a direct photochemical effect due to the early localization of the photosensitizer in the RPE, or a depigmentation or photobleaching of the RPE, which led to a window defect in the fluorescein angiogram without loss of the major functional properties of the RPE, are possible mechanisms involved in the development of the documented lesion.",0
Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.,1
Controversy exists over the appropriateness of administering haematopoietic growth factors to healthy individuals.,0
The patient developed abdominal pain and high fever on Day 21 after the initiation of chemotherapy.,0
"Choline magnesium trisalicylate was then administered in an effort to control her fever, and was successful.",0
"During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.",1
"On the basis of the encouraging results of the initial series, this technique should be considered as an interesting therapeutic alternative in sciatica.",0
"One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.",1
Colchicine-induced myopathy in a teenager with familial Mediterranean fever.,1
"A 50-year-old diabetic and hypertensive male patient is reported who had ticlopidine-induced marrow aplasia partially responsive to colony-stimulating factors and corticosteroids, but experienced complete recovery with cyclosporine.",1
BACKGROUND: The anti-natriuretic properties of growth hormone (GH) are well established.,0
Two-thirds of the chronic cases improved markedly.,0
Tissue distribution of olanzapine in a postmortem case.,0
Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.,1
Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.,1
The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.,1
"The arterial ketone body ratio (AKBR), which is the ratio of acetoacetate to beta-hydroxybutyrate in arterial blood and which reflects the redox state in liver mitochondria, improved dramatically following treatment.",0
Hypernatraemia induced by sodium polystyrene sulphonate (Kayexalate) in two extremely low birth weight newborns.,1
The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.,1
"In followup, 18 patients reported limb dysfunction ranging from 5-365 days.",0
This report describes a probable case of infliximab-induced membranous nephropathy.,1
"We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.",1
Modern ergotism.,0
It is suggested that special precautionary measures should be taken regarding the dose and the route while administering epinephrine to avoid mishaps.,0
"A prolonged, complete disappearance of B-cells from the peripheral blood was observed.",0
Anterior ischemic optic neuropathy secondary to interferon alfa.,1
"A previous study of patients with ""quinine-associated TTP/HUS"" found that ADAMTS13 activities were not abnormal in 12/12 patients.",1
The symptoms are mainly caused by the space-occupying effect of the large number of cysticerci rather than by adjacent tissue swelling such as is seen in the presence of dying parasites.,0
Mefloquine-associated hypoglycaemia in a cachectic AIDS patient.,1
"The latter revealed sensitization to PTU during the acute phase of the disease, which was greatly reduced 5 weeks after discontinuation of the drug and was completely absent after 5 months.",0
A 21-year-old woman with pars planitis was treated with a subtenon's depot corticosteroid injection that was complicated by the appearance of the corticosteroid suspension within the choroidal vasculature.,0
Lead poisoning and recurrent abdominal pain.,0
These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.,1
Reduction in the number of cataplectic episodes per week after 20 weeks of treatment constituted the basis for efficacy determination.,0
The infection was treated successfully with systemic and intrathecal antibiotics without removal of the catheters.,0
"In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.",1
Three days later the patient could say a few single words and extra-ocular movement returned to normal.,0
"It is postulated that renal tubular damage secondary to the cumulative effects of repeated courses of aminoglycosides resulted in hypomagnesaemia, and we suggest screening for this problem by monitoring serum magnesium regularly in all patients with CF receiving multiple courses of aminoglycosides.",0
OBJECTIVES: To report a safe and reliable method for evaluating catheter dysfunction.,0
"Seventeen had deposits of plasma proteins at the dermoepidermal junction, 16 had deposits in the vessel walls, and one had autofluorescence of the nuclei in the epidermis and vessel walls.",0
The association of central diabetes insipidus (CDI) with lithium use is rare.,1
Burn of the auricle.,0
"In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.",1
METHODS: We describe a patient with MG and a steroid-induced major depressive episode with psychotic features treated with ECT.,0
Such a clinical association has not been previously described in the literature and might be due to the persistent expression of gp91phox at a very low level.,0
Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.,1
"METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.",1
"A rechallenge 3 months later caused similar pulmonary symptoms, confirming the association between the drug and the respiratory system.",0
"To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.",1
Trazodone-induced transient hypomanic symptoms and their management.,1
"Norethisterone in these 69 pregnancies accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive births.",1
Inflammatory mononuclear cells and granulocytes typically seen in patients with diffuse lamellar keratitis (DLK) were absent.,0
The extra care required may negate the financial advantages of the substitution.,0
"Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.",1
"We review the current English language literature on this entity and discuss its clinical features, histology, ultrastructure, etiology, and pathophysiology.",0
Caudal epidural blood patch for treating intractable vomiting in a child after placement of a permanent intrathecal catheter.,0
"Resting motor threshold (RMT), active motor threshold (AMT), MEP size, intracortical inhibition (ICI) and intracortical facilitation (ICF) were tested during and after suspension of hormonal therapy.",0
These symptoms resolved but recurred rapidly (within 24 h) and were more debilitating following a second exposure to the same antibiotics at the same doses 8 months later when the patient was readmitted for treatment of another cystic fibrosis-related pulmonary exacerbation.,0
CONCLUSION: This rare case of PTU-induced ANCA-associated vasculitis manifested with ototoxicity in combination with systemic involvement.,1
"Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.",1
Development of pemphigus herpetiformis in a patient with psoriasis receiving UV-light treatment.,0
"We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.",1
This eruption appears to be a distinct cutaneous toxicity of PLD.,1
This result suggests that a change in the serotonin reuptake mechanism may be involved in the effect of nc-EST on depression.,0
Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.,1
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
They are proof of a disturbed GABA metabolism in pyridoxine dependent seizures.,0
Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.,1
Therefore we recommend the less invasive approach first--urokinase therapy--to be followed by surgical intervention if thrombolysis is unsuccessful.,0
"One complication is toxic leukoencephalopathy, which is due to a direct toxic effect of chemotherapeutic agents on the central nervous system white matter.",0
"In this case, interferon alpha induced polymyositis and cardiomyopathy is diagnosed in a 33-yr-old male patient with history of chronic hepatitis B.",1
CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.,1
"Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol.",1
"The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.",1
"Rejection of blood transfusions by individuals of this faith is usually blamed to justify this attitude, thus leading to severe personal, medical and psychological distress related to the lack of care.",0
Complications of encephalitis of unknown origin were successfully treated with steroid therapy and the patient has been in CR for 16 months after BMT.,0
"MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation.",0
DISCUSSION: beta-Lactam-induced leukopenia is a rare but well-described adverse drug reaction.,0
We report a patient with linear IgA bullous dermatosis and gluten-sensitive enteropathy.,0
Possible mechanisms for damage to the urothelium by ketamine are suggested.,1
"He failed to improve when therapy was continued with low-molecular-weight (LMW) heparin (Fragmin, Kabi Pfrimmer, Erlangen, FRG).",0
"Shortly after the start of surgery, he suffered an allergic reaction that, at first, was difficult to distinguish from the recognised side-effects of intrathecal diamorphine.",0
A case of priapism associated with trazodone is described.,1
A 37-year-old male ingested 12 gm of fluoxetine approximately 2 hours prior to arrival at an emergency department.,0
"First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.",1
"The patient sustained a severe septic episode, was treated with antibiotics and GM-CSF, and recovered the 14(th) day after ticlopidine withdrawal.",0
"Her mother ingested therapeutic doses of nimesulide, a non-steroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy.",0
"Upon admission, the patient's vital signs were found to be within normal limits, as were his liver profile results, complete blood count, thyroid-stimulating-hormone level, and serum chemistry panel.",0
A case report.,0
CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.,1
"BACKGROUND: Visceral leishmaniasis is a protozoan infection usually asymptomatic, but can progress to fatal disease in immunocompromised hosts, especially in HIV patients.",0
"Therefore, calcium-channel blockers should be used carefully in peculiar cases of HOCM.",0
The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.,1
We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.,1
RATIONALE: The atypical antipsychotic clozapine is effective in the treatment of patients with refractory schizophrenia.,0
We emphasize the need for long term follow up of patients treated with purine analogs and suggest that even those who are apparently cured be monitored periodically.,0
"Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.",1
"Among the various clinical and pathological manifestations of hydrocarbon (HC) poisoning, pneumonitis is the most significant and occurs in up to 40% of children, whereas formation of pneumatoceles is believed to be a rare event.",0
"These cases emphasize the need for a high index of suspicion for tickborne illness in oncology patients, and the importance of a low threshold for starting empiric treatment before confirming the diagnosis.",0
Localized herpes simplex (HSV) type II following intra-articular corticosteroid injection is remarkable.,0
"Renal sonogram showed hyperechogenic medullary papillae, which resolved during convalescence.",0
"CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual ""shining,"" glare, color vision anomalies, and gradually decreased vision.",1
Tamoxifen retinopathy.,1
"PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.",1
Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia.,1
Erythema multiforme bullosum due to rifampicin.,1
A skin biopsy specimen disclosed intracorneal pustule composed of neutrophils and lymphohistiocytic infiltrate in the dermis.,0
"OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction.",1
"However, re-initiation of sunitinib treatment was followed by bilateral breast enlargement again.",1
Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.,1
Report of a case and review of the literature.,0
The only positive finding was enlargement of the abdomen without tenderness.,0
"The manual intravenous push has a greater possibility of inadvertent overdosage during some small time frame, as well as more local symptoms by some reports.",0
"Transvaginal intratubal insemination, ectopic pregnancy and treatment by single-dose parenteral methotrexate.",0
"The case of a patient with CPH, who had marked epigastric symptoms with indomethacin treatment and responded well to topiramate 150 mg daily, is reported.",0
Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.,1
"We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.",1
"The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.",1
The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.,1
Proposed mechanisms for leukemogenesis are presented.,0
"Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.",1
Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.,1
"Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects.",1
"BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.",1
"After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.",1
"Twenty-six months later, the patient is disease-free but continues to require pancreatic enzyme supplements.",0
"Various combinations of antibiotics have been successful in achieving cure; however, at present, high-dose penicillin (greater than 25 million units/day) in combination with an aminoglycoside for a period of six weeks appears to be the optimum therapy.",0
Successful treatment of massive pulmonary embolism with prolonged catheter-directed thrombolysis.,0
Among these are an increased incidence of both gram-positive and gram-negative infections and an increased incidence of gastrointestinal symptoms.,0
We presented a patient with status asthmaticus treated with a combination of theophylline and prednisone who developed a perforated gastric ulcer.,1
This is the first case of TMP-SMX-induced hypersensitivity syndrome associated with the reactivation of a latent viral infection.,1
An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.,1
"Even after its discontinuation, the patient experienced the rash on a long-term basis, with periodic exacerbations.",0
Nevertheless the patient lapsed into a hypotonic coma.,0
"In this article, we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma.",1
The optimal treatment is not well defined.,0
Chest radiographs and computed tomographic findings showed a mass in the right upper lobe and effusion.,0
Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.,1
"In early endophthalmitis, Staphylococcus epidermidis was isolated on vitreous culture in 4 (67%) of 6 cases, whereas in late endophthalmitis, this organism was isolated in only 1 (4%) of 27 cases.",0
"We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.",1
Post-transplant lymphoproliferative disorder following cytomegalovirus reactivation in a lung recipient.,0
Several patients successfully treated with halofantrine without any treatment failure have also been documented in Japan.,0
"The major features of akinetic-rigid syndromes are bradykinesia (small, slow movements), rigidity and tremor, often summarised as ""parkinsonism"".",0
"CONCLUSION: While thrombosis has been reported with GnRH-a therapy in men with prostate cancer, its association with treatment in this benign case may have been a consequence of the massive tumor size.",1
"In conclusion, myalgias were due to focal RML produced probably by a combination of factors, particularly the chemotherapy along with dehydration due to gastrointestinal complications, infection, and the use of diverse antibiotics.",0
Transarterial embolization given for hepatoma in a patient with Budd-Chiari syndrome resulted in hepatic infarction and inferior vena cava thrombosis.,0
Prompt recognition of a chlorambucil drug reaction is essential in patients receiving chemotherapy.,0
He underwent the desensitization without incident on repeated infusions.,0
"Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.",1
"We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).",1
There was no evidence of another cause of colonic ischaemia.,0
"A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",1
CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.,1
CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.,1
The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.,1
The patient developed a broad-QRS-tachycardia and severe hypotension.,0
"We describe the case of a 17-year-old boy with a right apical paraspinal Ewing's tumour in the neck treated with induction chemotherapy, high-dose chemotherapy (busulfan and melphalan) with peripheral stem-cell rescue and, 4 months later, radiotherapy to the primary tumour site (cervical cord received 50 Gy in 30 fractions).",0
Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.,1
"Among atypical antipsychotic, clozapine, risperidone and olanzapine have been reported to be associated with the condition.",0
"Moreover, the in vitro culture of bone marrow from a second HS patient showed a GM-CSF dose-related increase in colony formation up to a dose of 250 units/ml.",0
Multicentric canine lymphoma in a 12-year-old keeshond: chemotherapy options.,0
Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.,1
Arthritis and bursitis in multiple sclerosis patients treated with interferon-beta.,1
"Based on the Naranjo algorithm, the adverse reaction observed was probably related to the hydroxyurea treatment (score = 6); however, the hydroxyurea chemotherapy could not be discontinued because of the myeloproliferative disorder.",1
MCC seems to be common in transplant recipients and 52 cases have been reported in the literature.,0
Several alternatives presently exist for patients considering surgical rhinoplasty.,0
"CASE REPORT: 1.5 years after resection, hyperfractionated radiotherapy and chemotherapy of an anaplastic ependymoma in the right parietal region, the cranial MRI of an 11-year-old girl showed multiple small contrast-enhanced lesions in the frontal cortex.",0
The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.,1
"AIMS: To present a case of piloerection after replacing fluvoxamine maleate with milnacipran hydrochloride, and to analyse this effect based on receptor occupancy theory.",1
This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.,1
"An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.",1
Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.,1
"Delusional disorder, somatic type (DDST) is a rare psychiatric disorder and the treatment is mostly based on observations, due to the lack of well-organized studies.",0
We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.,1
The unmedicated eye remains asymptomatic to date.,0
"Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon.",1
The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental.,1
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.,1
We report on two patients with PPG following breast surgery who were successfully treated with low-dose cyclosporin (2.5-5 mg/kg per day).,0
Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment.,1
"We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.",1
"We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.",1
Both 6-MP and AZA are widely used and are known to cause hepatotoxicity in a proportion of patients.,1
We believe this to be the first culture-proven case of L. micdadei PVE reported in the literature.,0
Steroid rosacea is a facial dermatitis clinically resembling acne rosacea.,0
"These features were initially ascribed to the veno-occlusive disease caused by pyrrolizidine alkaloids, radiotherapy and some therapeutic drugs but have not been described in detail as a complication of AMD therapy.",0
Elevated serum triglycerides with clozapine resolved with risperidone in four patients.,1
Severe hypomagnesemia occurred in this patient and published literature is highlighted.,0
"Finally, leukocyte and platelet counts increased and remained within normal range following IgG therapy in the third patient having SLE-associated leuko- and thrombocytopenia.",0
"CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias.",1
We describe the case of a 56-year-old man who had high aminotransferase levels and anti-hepatitis C virus (HCV) antibodies.,0
Henna (Lawsonia inermis Linn.) induced haemolytic anaemia in siblings.,0
"A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.",1
The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.,1
We report a case of fulminant neuroleptic malignant syndrome in a man aged 70 developing within 12 hours of starting six-hourly intravenous metoclopramide.,1
There was serological evidence of a recent Group A streptococcal infection.,0
"Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.",1
RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.,1
"Additionally, clinically effective doses of conventional antipsychotics can actually aggravate negative symptoms through the development of extrapyramidal symptoms (EPS).",0
A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide.,1
"Diagnosis was based on a history of repeated exposure to sulfonamides, skin biopsy findingd, and clinical recovery on cessation of sulfonamide therapy.",0
CONCLUSION: Alendronate led to nodular scleritis and rechallenge caused recurrence of scleritis.,1
"A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.",1
"This case suggests that highly angiogenic tumours such as angiosarcoma may be effectively palliated using agents usually reserved for refractory Wilms' tumour, and supports the view that adult Wilms' tumour is more sensitive to such agents.",0
These movements were dose-related and completely abated on reducing the dose.,0
"We believe that this represents an unusual case of moderate-dose MTX-induced neurotoxicity in a patient with gastric cancer, which has not previously been reported.",1
Radiation recall pneumonitis induced by gemcitabine.,1
Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma.,1
"We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.",1
"In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.",1
"IMPLICATIONS FOR NURSING PRACTICE: With any new treatment option, it is imperative that nurses understand how agents work to enrich their own knowledge base, as well as have a strong foundation for patient education.",0
Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.,1
"An objective causality assessment indicated a probable relationship between clotting abnormality and warfarin administration, although the degree of elevation of the INR was unusual in the light of the daily warfarin dose and duration of its exposure.",1
"We report on three patients who developed acute liver damage during therapy with itraconazole, and in whom liver biopsy specimens were obtained.",1
The catheter was safely removed surgically; pathology examination showed no residual thrombus.,0
This report presents a case of colon perforation which occurred 4 months after treatment with intraperitoneal chromic phosphate for stage IB ovarian papillary serous cystadenocarcinoma.,1
"The patient suffered no side effects, and use of G-CSF represents an important addition to the management of a life-threatening drug reaction.",0
"Histopathological findings include focal vacuolar alteration of the basal layer with cytoid bodies, dermal and intraepidermal multinucleated giant cells and a mixed chronic inflammatory infiltrate with a lichenoid pattern consisting of lymphocytes, histiocytes, eosinophils and plasma cells.",0
Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.,1
Bone formation induced in an infant by systemic prostaglandin-E2 administration.,1
We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.,1
"Neuropathy is a significant side effect of thalidomide therapy, which may limit its clinical use.",1
"A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.",1
"To our knowledge, neither the association of SINS and ankylosing spondylitis nor vertical diplopia as its presenting complaint has been described.",0
At post-mortem there was minimal leukaemic infiltration but there were alterations in the liver architecture sufficient to explain the portal hypertension.,0
Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.,1
CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.,1
A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.,1
"The results of laboratory tests revealed elevated levels of hepatic enzymes, including alanine transaminase (ALT) and aspartate transaminase (AST).",0
The role of Adriamycin in the production of cardiotoxicity is reviewed.,1
Acute coronary artery occlusion during percutaneous transluminal coronary angioplasty: reopening by intracoronary streptokinase before emergency coronary artery surgery to prevent myocardial infarction.,0
It is concluded that cyclophosphamide and thiotepa in obese patients should not be dosed on the basis of BSA incorporating TBW since the patient will be overexposed.,0
The intense stimulation of B lymphocytes and decreased T lymphocyte activity in asbestos-exposed populations may result in development of B-cell malignancies.,0
"Oral pilocarpine tablets, as well as another muscarinic agent (cevimeline), have recently been approved for the treatment of dry mouth (xerostomia).",0
"One hour after she drank the second bowl of herbal decoction, she suddenly developed tonic contractions of all her limb muscles and carpopedal spasm lasting 5 min, difficulty in breathing, chest discomfort and perioral numbness.",0
Transient global amnesia after clioquinol: five personal observations from outside Japan.,1
We report two patients with acne vulgaris with a fourth type of minocycline-induced cutaneous pigmentation.,1
Before therapy 14 of the patients were unemployed; after therapy only two did not work.,0
The Center for Disease Control has received numerous reports of an eosinophilia-myalgia syndrome related to products containing L-tryptophan.,1
"From this study and the previously available data, we conclude that this drug is too toxic for human trials at the currently recommended doses.",0
Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.,1
"We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.",1
Uses and safety of acyclovir in pregnancy.,0
Topical application of glucocorticoids and dimethisone is helpful.,0
One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.,1
"Although they are rare, they may be life-threatening and should therefore be immediately recognized.",0
There is a dose-effect relationship between doxorubicin and the incidence of symptomatic cardiac failure.,1
"All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.",1
One patient has a resistance-related mutation (M460I); the major risk factor for emergence of resistance in this patient was the presence of early and persistent antigenaemia.,0
"Up to four percent of patients treated with imatinib may develop hepatotoxicity, which usually resolves with discontinuation of the drug.",1
"It may become manifest as perilesional linear, depigmented, atrophic streaks, which are usually most prominent in patients with dark-colored skin.",0
Reports of corticosteroid anaphylactic reactions are rare in the medical literature.,0
A patient with severe cholestatic jaundice induced by captopril is presented.,1
"After two months of therapy, repeat echocardiography showed complete resolution of the thrombus.",0
Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.,1
"A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis.",1
Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.,1
The frequencies and cytokine-producing phenotypes of phenytoin-specific T cells were examined simultaneously by using a carboxyfluorescein succinimidyl ester (CFSE) dilution assay.,0
"CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.",1
"A conjunctival biopsy revealed invasive squamous cell carcinoma, with orbital invasion on computed tomography scan.",0
Thymic hyperplasia can occur after cytotoxic therapy for various malignancies.,0
This illustrates intravenous pamidronate as a valuable therapeutic tool when milk-alkali syndrome presents as hypercalcemic emergency.,0
The patient was successfully treated with heparin and subsequently with warfarin and dipyridamole.,0
A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger.,1
"Other reports show increases with the atypical antipsychotics, olanzapine and quetiapine.",0
"The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.",1
"Several studies have provided evidence suggesting that ""placebo effects"" represent conditioning phenomena and that learning processes influence the response to placebo medication.",0
Histological changes after the use of mycophenolate mofetil in autoimmune hepatitis.,0
Antivenin reactions developed in three.,0
We describe our modified technique for custom-made articulating spacers.,0
It is a potentially serious reaction which is little influenced by which drug is injected.,0
"After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.",1
This is the first CT demonstration of widely disseminated living cysticerci in brain and muscles.,0
None of the side effects observed resisted treatment or was severe enough to warrant discontinuation of therapy.,0
Lithium-induced Creutzfeldt-Jakob syndrome.,1
PATIENTS: A male infant born by cesarean section with a birth weight of 2.6 kg.,0
"There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.",1
Case studies in heparin-induced thrombocytopenia.,1
METHOD: Case report.,0
A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.,1
Acute drug induced hepatitis due to erlotinib.,1
"ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.",1
"We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.",1
"Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.",1
Development of Peyronie's disease during long-term colchicine treatment.,1
"Administration of sumatriptan in subarachnoid haemorrhage (SAH) patients, misdiagnosed as migraine patients, may induce symptomatic cerebral vasospasm with potentially dangerous consequences.",1
Two attempts at carboplatin desensitization were unsuccessful.,0
Subsequently he responded to the West Berlin Protocol.,0
Despite they can be distinguished through clinical and histological characteristics; both are often used as synonyms.,0
With these measures PaO2 could be maintained of safe levels but PEEP and high inspired oxygen concentrations were needed postoperatively until the trachea could be extubated on the third postoperative day.,0
"Subsequently, when ferrous sulfate was discontinued, the patient became hyperthyroid while taking the higher dose of thyroid hormone preparation.",0
"After recovery, in an attempt to provide adequate calories and to elucidate the inciting agent, he was rechallenged with his original total parenteral nutritional solution which contained 500 ml/day of a 20% fat emulsion.",0
The nephrotic syndrome responded again to withdrawal of lithium and institution of steroid therapy.,0
"To the best of our knowledge, this is the first report on the treatment of Stenotrophomonas maltophilia bacteremia after living donor liver transplantation.",0
On the third occasion the patient redeveloped severe hypotension and a generalised rash during general anaesthesia.,0
"We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.",1
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.,1
"In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.",1
No other drugs were detected.,0
An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.,1
"Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.",1
This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine.,1
CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.,1
"The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown.",1
The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.,1
"RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity.",1
"However, the implication of TMP/SMX inducing aseptic meningitis has been underreported to FDA/MEDWATCH program.",0
Circulatory arrest ensued.,0
"Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.",1
Ocular ethambutol toxicity.,1
The available data suggest that there is a possibility of risk of major malformations with the anticonvulsants.,0
RESULTS: The patient underwent anticoagulation therapy without removal of screw.,0
OBJECTIVE: To draw attention to severe presentations of atypical neuroleptic related diabetes and to document that a marked degree of remission can take place after drug withdrawal.,0
"We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.",1
"Although its side effects are few, tamoxifen increases the incidence of proliferative lesions of the endometrium, which theoretically should be preventable with progestational agents.",1
Torsemide appears to also be a part of a long list of agents that can cause pancreatitis.,1
L-asparaginase is a key component of the antileukemic therapy in children with acute lymphoblastic leukemia (ALL).,0
No chimeric glomerular cell was detected.,0
Case failure analysis and a review of the literature.,0
A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.,1
A less frequent side effect that is becoming more recognized is neurologic toxicity.,0
Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.,1
Subfoveal choroidal neovascularization in a patient with hemicentral vein occlusion.,0
"We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.",1
These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.,1
"The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease.",1
There is likely to be increasing pressure on pediatricians and other health professionals to prescribe HBO(2).,0
Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.,1
She was subsequently admitted to hospital and was diagnosed as having nephrotic syndrome.,0
"A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.",1
"Mycobacterium tuberculosis was isolated in a culture of peritoneal fluid, and the patient responded promptly to antituberculous therapy.",0
"If epidural analgesia is used, opioids may be preferred over local anaesthetics in the immediate postoperative period to prevent masking of an anterior spinal artery syndrome.",0
"Although serologic tests for Epstein-Barr virus (EBV) indicated a previous infection, EBV deoxyribonucleic acid was detected in her serum by polymerase chain reaction.",0
Ampicillin-induced interstitial nephritis with generalised exfoliative dermatitis.,1
"Administration of lamotrigine, especially in combination with valproic acid, may lead to the development of TEN.",1
"Clozapine is the first choice antipsychotic medication for treatment-refractory schizophrenia; however, there are some disadvantages in using clozapine.",0
A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day.,1
It must be distinguished from bilateral occipital lobe ischemia caused by vertebrobasilar system disease.,0
"A patient with ulcerative colitis developed skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology, while taking sulfasalazine.",1
Cyproheptadine for intrathecal baclofen withdrawal.,0
Augmentation of aripiprazole with low-dose clozapine.,0
"We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.",1
She was treated with acyclovir and subsequently developed VZV antigen-positive zoster.,1
Propafenone is an effective antiarrhythmic drug used widely for the treatment of supraventricular and ventricular arrhythmias.,0
Two anaphylactic deaths after chemonucleolysis.,0
Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.,1
"Resolution occurred in spite of continuous tocolytic therapy, which was stopped at 35 weeks.",0
A drug interaction between zafirlukast and theophylline.,1
"Treatment of ELP in children is generally supportive, with the symptoms and roentgenographic abnormalities resolving within months after stopping the use of mineral oil.",1
"We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.",1
Recommendations are made for the prophylaxis and treatment of sulfadiazine-related renal toxic reaction.,0
"However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.",1
There was complete recovery of hair loss and the regrowth started after 12 weeks of alopecia.,0
The authors hypothesize that inhibition of glucuronidation is responsible.,0
Reperfusion was achieved by coronary thrombolytic therapy with urokinase.,0
Death from inappropriate therapy for Lyme disease.,0
Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.,1
Trans-catheter hepatic arterial injection of lipiodol soluble anti-cancer agent SMANCS and ADR suspension in lipiodol combined with arterial embolization and local hyperthermia for treatment of hepatocellular carcinoma.,0
"DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.",1
CONCLUSION: Hypersensitivity reaction should be considered in patients who develop recurrent eosinophilia and deterioration of pulmonary function following the use of tobramycin by inhalation or by intravenous administration.,1
Toxoplasma polymyositis was diagnosed in a dog given repeated injections of glucocorticoids for a skin condition.,0
"CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.",1
"Our case is that of a 44-year-old woman, along with a review of the literature.",0
The child developed the nephrotic syndrome at the age of 17 months.,0
"These two cases of acute leukemia, which developed 3 years after diagnosis of breast cancer and initiation of chemotherapy, were characterized by trilineage dysplasia and pancytopenia, and had abnormalities of chromosomes 5 and 7: characteristics consistent with treatment-related leukemia.",0
Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.,1
A full vasculitis screen was negative.,0
Liver biopsy showed bridging hepatocellular necrosis as well as canalicular cholestasis.,0
The nephrotic syndrome developed in a patient receiving therapy with gold for rheumatoid arthritis.,1
"This trial was designed to evaluate intraarticular delivery of a tumor necrosis factor alpha (TNF-alpha) antagonist, through an adeno-associated virus (AAV) type 2 delivery system, for inflammatory arthritis.",0
"The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.",1
Progressive hypokalemia developed during phosphate treatment.,1
Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.,1
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
We present a patient with systemic lupus erythematosus who presented with nephrotic range pseudoproteinuria using an acid precipitation method of testing.,0
Fulminant liver failure has not previously been described with concomitant use of atenolol and N-acetylcysteine.,0
Ten years of behavioral data are presented to support the hypothesis that phenobarbital was exacerbating maladaptive behaviors.,1
Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).,1
Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.,1
The intensive care unit (ICU) represents a dynamic interaction between patient factors and interventional factors.,0
"In patient 2, thrombolysis caused mobilisation of thrombotic mass as evidenced by disappearance of thrombus on ultrasound.",0
"Two weeks before angioedema, the patient had started a new topical treatment with a gel containing 10% BP for acne.",0
Fulminant hepatic failure associated with bicalutamide.,1
Hypersensitivity reactions to aromatic anticonvulsants are associated with anti-liver microsomal antibodies which recognise rodent proteins.,0
"We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.",1
Allele-specific polymerase chain reaction (PCR)-based methods are now available for genotyping using leukocyte DNA.,0
Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.,1
CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.,1
"This case report describes the classic presentation of the syndrome, emphasizing the oral manifestations.",0
We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine.,1
Pathophysiologic concerns have also been a key reason why physicians have avoided using beta-blockers in patients with diabetes.,0
"A 54-year-old woman with recurrent adenocarcinoma of the uterus was treated with new third-generation cephalosporin, cefmenoxime, for a urinary tract infection.",0
Pustular psoriasis-like tinea incognito due to Trichophyton rubrum.,0
A 61-year-old male with a history of severe heparin-induced thrombocytopenia (HIT) type II after aorto-femoral bypass surgery presented to the emergency department within 8 hours of development of substernal chest pain radiating to the left arm.,0
OBJECTIVE: We describe atypical motor and cognitive features in a case of familial Alzheimer disease (FAD) due to presenilin-1 (PS-1) mutation.,0
"OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.",1
The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode.,1
Three of the five patients had undergone endoscopy.,0
"CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.",1
BACKGROUND: Delivery of tobramycin by inhalation to the lungs of patients with cystic fibrosis (CF) who are infected with Pseudomonas aeruginosa has been proven to be effective and safe.,0
"Proliferation of abnormal bone marrow histiocytes, an undesired effect of granulocyte macrophage-colony-stimulating factor therapy in a patient with Hurler's syndrome undergoing bone marrow transplantation.",1
Serial radiographic observation over two months.,0
"Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.",1
Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema.,1
Severe histological osteomalacia developed in a woman with Crohn's disease 2 years after ileal resection and the start of cholestyramine therapy.,1
We report a patient with inoperable pancreatic cancer who developed gastrointestinal bleeding secondary to radiation-recall related to gemcitabine and review literature.,1
"The patient was treated by chemotherapy only, without surgery, which seems to be most appropriate for the early stages of this disease.",0
Suspected ciprofloxacin-induced interstitial nephritis.,1
The case is of interest for two reasons: it is very rare for a case of malignant osteopetrosis to survive until adulthood and to be aware of the potential dental and oral complications of the disorder.,0
A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand.,1
"Because of its favorable tolerability profile it appears to be a preferred alternative, especially in NSAID-sensitive patients.",0
"All three cases demonstrate that hyperosmolar hyperglycemic nonketotic coma is a serious potential complication of systemic steroidal therapy, even in a short course of treatment such as is often used in ophthalmology.",0
OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.,1
The patient was ultimately treated with a nasal septal button with good symptom relief.,0
Capecitabine-induced headache responding to diltiazem.,1
The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor.,1
"The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.",1
Such anagen effluvium with lichenoid eruption following INH therapy has not been observed previously.,1
"We present a case of interstitial pneumonitis and diffuse alveolar hemorrhage, which represents the second such case reported in the literature.",0
We indicate that initial and early treatment of the patients with DM and PnM with CsA enabled rapid tapering of the dose of glucocorticoid and improved the disease.,0
Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed.,0
METHODS: Hospital records at St.,0
The delirium was not affected by administration of alprazolam.,0
"In most European recommendations, the empirical antibiotic treatment is directed against ""the most likely pathogen,"" based on epidemiological, clinical, and laboratory data, and on the severity of illness.",0
Rapid diagnosis may avert unnecessary changes in therapy to treat conditions which clinically mimic NEH.,0
Serious adverse events experienced by patients with chronic heart failure taking spironolactone.,1
Transient obstruction of the mitral valve by a massive thrombus complicating percutaneous valvuloplasty.,0
We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone.,1
Acute esmolol toxicity may be self-limiting because of its extremely short half-life.,1
Corneal interface abscess after excimer laser in situ keratomileusis.,0
"When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.",1
B-cell lymphoproliferative disorders are rare but serious complications of solid organ and bone marrow transplantation.,0
"Contact dermatitis, an inflammatory response of the skin to an irritant or an allergen, can affect hospital staff.",0
Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.,1
A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.,1
"We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.",1
This report presents a potential case of risperidone-induced tardive dyskinesia.,1
The fifth patient exhibited paraesthesia and agitation caused by olanzapine that was misdiagnosed as psychotic agitation.,1
We report here a case of TEN after administration of ciprofloxacin.,1
We describe two cases of PSVT that changed to non-sustained polymorphic ventricular tachycardia after administration of verapamil.,1
A recent consensus suggested that endoscopic injection of tissue glue for gastric variceal obliteration (GVO) should be the first choice for treatment of acute gastric variceal bleeding.,0
Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.,1
We discuss the possible role of using immunomodulating agents for the treatment of this syndrome and suggest that alternative regimens should be given special consideration especially in those critical clinical situations where supportive measures appear to be unsuccessful.,0
"Although a definitive causal relationship between the steroids and AI was not established, their temporal association and the exclusion of other possible etiologies led us to postulate that AI was a complication of the steroid protocol.",0
Infusion of fresh frozen plasma together with aspirin and dipyridamole resulted in recovery of microangiopathic hemolytic anemia and thrombocytopenia.,0
"She had no history suggestive of gastroesophageal reflux, peptic ulcer, or pork allergy, and no vomiting on days when enzymes were not given.",0
"To date, stent fractures reported have been related to aggressive post dilation.",0
Blood counts returned to normal 6 days after institution of granulocyte colony stimulating factor therapy.,0
Two patients are alive at 16.4 and 22.5 months after initial treatment.,0
The past medical and occupational history was negative.,0
"The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).",1
Usefulness of antiplatelet drugs in the management of heparin-associated thrombocytopenia and thrombosis.,1
The mechanism by which sunitinib induces gynaecomastia is thought to be associated with an unknown direct action on breast hormonal receptors.,1
"In summary, because infected grafts can lead to serious complications, besides careful donor screening, it is important to achieve early recognition of contaminated organs by culturing the perfusate to start specific antibiotic or antifungal therapy after transplantation if necessary and avoid the rare but, in this case, fatal consequences of these infections.",0
"After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.",1
High-dose tamoxifen was recently reported as a novel treatment for patients with malignant gliomas who have failed standard therapies.,0
Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.,1
We describe a patient in whom this interaction caused a series of dangerous clinical events.,0
Gastric stump lymphoma after distal gastrectomy for benign peptic ulcer: Report of a case.,0
Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.,1
Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug.,1
"This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.",1
"Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.",1
CASE: We report a 17-year old JRA patient with primary ovarian diffuse large B-cell non-Hodgkin's lymphoma (NHL).,0
Hepatic adenomas are rare tumors; they have been associated with the use of anabolic steroids.,0
"A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.",1
"It was not accompanied by clinical hallmarks of hypersensitivity, which is suggestive for metabolic rather than for immunoallergic idiosyncrasy.",0
"Toxicological analysis of the blood revealed GHB 165.6 mg/L, and 90.7 mg/L in the urine.",0
"One patient had known atherosclerotic heart disease, and 2 patients had risk factors for coronary artery disease.",0
"Researchers and clinicians have made numerous suggestions for managing the various side effects, although there is currently no research to guide evidence-based practice.",0
"So this potential drug-drug interaction could be investigated, the patient stopped taking both drugs for 1 week.",0
Recombinant human erythropoietin in patients with myelodysplastic syndrome and myelofibrosis.,0
"The spectrum of renal lesions occurring during antituberculous therapy, particularly in association with rifampin, may be wider than previously suspected.",1
We regard the association recorded in this case to be a coincidence despite the known association between the drug and the development of immunosuppression and lymphoma.,0
An unrelated allogeneic stem cell transplantation was performed.,0
A 78-year-old man with severe chronic obstructive pulmonary disease presented to our pain medicine clinic for treatment of post herpetic neuralgia.,0
We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.,1
"In high-risk patients with NSTE ACS for whom an early invasive strategy is planned, enoxaparin and UFH are the agents with the highest level of evidence (evidence level A).",0
Sideroblastic anemia due to linezolid in a patient with a left ventricular assist device.,1
"One RA patient and one AA patient have received rEpo as maintenance therapy for more than 64 and 100 weeks, respectively.",0
We present the first case of a patient with priapism after oral intake of the phenothiazine prothipendylhydrochloride.,1
"During the epidemic period, 43% of the S typhimurium isolates submitted to the Arizona Department of Health Services were resistant to chloramphenicol, and 80% of these possessed the same plasmid resistance.",0
"In immunodeficiency conditions, unusual forms of leishmaniasis can develop and foster the risk of a diagnostic delay and of poor response to therapy.",0
Post-allogeneic BMT complications include graft-versus-host disease (GVHD).,0
This case emphasizes the importance of making interventions based on individual patient response.,0
"We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.",1
This occurred after the first cycle of cisplatin and then again after the second cycle.,0
"Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.",1
"Patients typically have surgical rhinoplasty to correct unsightly noses resulting from trauma, surgery, or heredity.",0
"For those patients with a history of NMS, or even of isolated serum CK elevation during antipsychotic therapy, follow-up should be stricter.",0
Following are two clinical case reports demonstrating profound cerebral edema associated with implantation of Gliadel wafers.,1
Discontinuation of co-trimoxazole normalized serum potassium level and symptoms.,0
"Indirect immunofluorescence demonstrated dermal binding IgA antibodies, and Western blotting of serum showed reactivity with a 250 kDa dermal antigen corresponding to collagen VII of anchoring fibrils.",0
CONCLUSIONS: The mechanism by which loop diuretics induce pancreatitis appears to be via an immunologic pathway.,0
Propranolol-induced hypertension in treatment of cocaine intoxication.,1
The situation is less clear regarding other anti-malarial quinine analogues.,0
"Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.",1
The current case demonstrates that some cystoid macular edema may not be responsive to vascular endothelial growth factor blockade alone.,0
"After 1 week of nefazodone therapy the patient experienced headache, confusion, and ""gray areas"" in her vision, without abnormal ophthalmologic findings.",1
Acute and transient ST segment elevation during bacterial shock in seven patients without apparent heart disease.,0
He was later skin tested to confirm allergy to MTX.,1
Ischemic stroke associated with cough and cold preparation containing methylephedrine and supplement containing Chinese herbal drugs.,0
The use of epidural local anaesthetics immediately after surgery delays the diagnosis of a postoperative neurological deficit.,0
"All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.",1
"CONCLUSION: Despite adequate measures to prevent infection, orbital cellulitis may complicate strabismus surgery.",0
"Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.",1
Data suggest that tamoxifen is involved in the pathogenesis.,0
Oseltamivir was well tolerated outside vomiting during the first three days of treatment in one patient.,0
"Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.",1
METHODS: Retrospective consecutive noncomparative case series.,0
Oxaliplatin is a new platinum derivative that has significant activity in patients with metastatic colorectal carcinoma.,0
"Many of such strokes are asymptomatic, but some are devastating.",0
"Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",1
A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.,1
BACKGROUND: The skin contains a system for producing serotonin as well as serotonin receptors.,0
Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia.,1
We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.,1
"Three patients with niacin-induced visual symptoms had cystoid maculopathy without leakage on fluorescein angiography, and a fourth patient with no fundus abnormality experienced cessation of visual symptoms upon discontinuation of niacin.",1
"We believe that methotrexate represents a relatively effective alternative to surgery in patients with early unruptured tubal pregnancy, but suggest that it be used with caution in view of possible systemic toxicity.",0
The association between the use of cyproterone acetate and liver abnormalities is poorly documented.,0
"Parkinsonian features were progressive, even after the patients had stopped work.",0
We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.,1
"Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.",1
CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.,1
"The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.",1
Two cases of hypothyroidism in patients with chronic hepatitis C treated with recombinant alpha interferon are reported.,1
Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.,1
We evaluated both healthy ferrets and animals in which we first induced tracheal inflammation with bacterial endotoxin (a lipopolysaccharide [LPS]).,0
The case of a 67-year-old man with acute myocardial infarction with ST-segment elevation after a wasp sting treated with fibrinolysis and without significant coronary atherosclerosis is reported.,0
Various hypotheses as to the complex actions of morphine and its antagonist in epileptogenesis are discussed.,0
Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease.,0
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
Two boys were treated with methylprednisolone due to acute exacerbations of Crohn disease.,0
We describe a patient who became hypothyroid while taking ferrous sulfate.,1
Nitrous oxide produces irreversible oxidation to the Co++ and Co forms that renders vitamin B12 inactive.,0
Magnetic resonance imaging (MRI) showed superior sagittal sinus (SSS) thrombosis and meningeal enhancement.,0
"Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat.",1
Use of the Naranjo probability scale determined the association between cephalosporin use and leukopenia to be probable.,1
Well-known signs of methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration.,1
"Although, not included in the incidence calculation, four patients with CLL were referred at the time of development of AML/MDS.",0
"It includes a description of the complication, how it occurred, was recognized, and corrected.",0
"This small series of adult patients with leukaemia illustrates difficulties in treating patients who are practising JW, yet nevertheless provides a significant argument against the prejudicial decision leading to evasion of treatment in these patients.",0
"On this mechanistic basis, we treated three consecutive patients with metastatic PEComa with an oral mTOR inhibitor, sirolimus.",0
Electrical proarrhythmia with procainamide: a new ICD-drug interaction.,1
To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-beta therapy for the malignant melanoma.,1
We report a case of a scleroderma-like reaction induced by long-term administration of UFT.,1
Nineteen immunocompromised patients with extensive skin lesions caused by Pseudomonas aeruginosa with or without P. aeruginosa bacteremia were analysed.,0
"Coagulation parameters of 3 different time-points were assessed and compared: before administration of any blood product (time-point 1), before administration of the first dose of rFVIIa (time-point 2), and 4 hours after the administration of the last dose of rFVIIa (time-point 3).",0
Failure of coagulation was confirmed by thrombelastography and in both cases routine coagulation tests revealed a prolonged kaolin cephalin clotting time (KCT).,0
We present a case in which dipyridamole induced high-grade atrioventricular (AV) block that responded promptly to intravenous aminophylline but not to atropine.,1
Report of a case and review of the literature.,0
They provided conflicting testimony as to alleged violations of the standard of care.,0
The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.,1
"Combination disease modifying antirheumatic drug therapy was common, with 82/171 (48.0%) taking methotrexate (MTX), 15/171 (8.8%) hydroxy-chloroquine, 11/171 (6.4%) sulfasalazine, and 8/171 (4.7%) anti-tumor necrosis factor therapy.",0
"Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.",1
"CONCLUSIONS: Life-threatening adrenal suppression, requiring hydrocortisone supplementation and intensive therapy, was observed and successfully treated in a newborn, whose mother had received high-dose methylprednisolone in late pregnancy.",1
Subsequent liver biopsy showed low-grade lobular hepatitis.,0
The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.,1
"A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.",1
Lansoprazole-induced thrombocytopenia.,1
"Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.",1
Thrombocytopenia of Grade III or higher was observed in eight patients.,0
"He developed pronounced eosinophilia and a vasculitic skin rash, myalgias of the abdomen, upper trunk, and neck, and died of respiratory distress with no evidence of an infectious etiology.",0
"Blood sugar and A1c were finally stabilized one month after discontinuation of olanzapine (A1c,6.9%).",0
He became febrile and developed a productive cough and pulmonary infiltrates on postoperative day 4.,0
We propose a mechanism of vancomycin-induced mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE.,1
Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.,1
"Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.",1
"While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.",1
Pamidronate therapy should be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.,1
CONCLUSION: Acetic acid is corrosive and may cause vagina bleeding.,1
Disopyramide (Norpace)-induced hypoglycemia.,1
Mitral valve endocarditis resulting from coagulase-negative Staphylococcus after stent implantation in a saphenous vein graft.,0
"A rechallenge, performed in both patients, confirmed the diagnosis of mesalamine-induced pancreatitis.",1
"We describe the case of acute hepatitis induced by gliclazide, a second generation sulfonylurea.",1
"He was treated by the administration of vancomycin, fluconazole, and pazufloxacin mesilate.",0
The diagnosis was confirmed by immunofluorescent studies.,0
We report a case of carcinoma following 42 years of chronic empyema in a patient who underwent surgery for a hydatid cyst at the age of 3.,0
Pharmacologic and psychotherapeutic issues in coexistent paranoid schizophrenia and narcolepsy: case report.,0
Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.,1
Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.,1
"Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.",1
It has been suggested that PPE caused by cytarabine does not recur with subsequent cytarabine re-challenge.,1
Two animals were injected with balanced salt solution as controls.,0
Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.,1
"Once ACAD has been established, treatments such as coronary angioplasty, coronary stenting, and coronary bypass are performed.",0
Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.,1
An intertrigo-like eruption from pegylated liposomal doxorubicin.,1
PURPOSE: To report patients who presented to the oculoplastics department for repair of cicatrical entropion after topical use of dipivefrin.,1
Ramipril therapy resulted in an important reduction of proteinuria (0.3-0.5 g/24 h): no changes were observed in arterial pressure and renal function during the 12-month follow-up.,0
"Depigmentation has been described with local steroid injections for other dermatologic conditions, but has not been reported previously with treatment of infantile ocular adnexal hemangiomas.",0
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.,1
"Similar precursor stages, usually not recognised by clinical laboratory tests and consisting of areas of hyperplasia of hepatocytes and sinusoidal cells and sinusoidal dilatation, lead potentially to hepatic adenoma, carcinoma, peliosis, and angiosarcoma.",0
"CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.",1
Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.,1
SIADH appeared to be transient and asymptomatic in our patients.,0
Renal pathologic findings were consistent with minimal change nephrotic syndrome (MCNS) showing extensive foot process effacement of visceral glomerular epithelial cells (podocyte).,0
Some of these patients may have been previously treated with radiotherapy.,0
Nonfatal prolonged overdosage of pyrimethamine in an infant: measurement of plasma and urine levels using HPLC with diode-array detection.,0
"A 51-year-old male patient with living, unrelated kidney transplantation in Iran in June 2001, developed Plasmodium falciparum P. falciparum infection.",0
None of these patients were operated on.,0
There was one reported death.,0
RESULTS: A 30-year-old woman with polycystic ovary syndrome developed bilateral anterior uveitis during ovulation induction therapy.,0
Acute adrenal insufficiency after large-dose glucocorticoids for spinal cord injury.,0
Ballistic movements due to ischemic infarcts after intravenous heroin overdose: report of two cases.,1
Their hair grew back after 2-3 months steroid therapy.,0
"The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).",1
Sirolimus-eluting stent thrombosis several years after clopidogrel discontinuation.,1
Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.,1
Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.,1
We report three cases of severe hypocalcaemia associated with i.v. bisphosphonate treatment in patients with multiple myeloma.,1
"Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.",1
OBJECTIVE: To report a case of HIV-related lipodystrophy with a rapid onset of symptoms from epidural lipomatosis in the wake of protease inhibitor and steroid treatment.,0
"The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.",1
Anaphylactoid reaction to 50% solution of dextrose.,1
Early postsplenectomy arthritis caused by penicillin-resistant Streptococcus pneumoniae.,0
Her course was further complicated by exudative pleural effusion and pneumonia despite receiving 10 days of clindamycin therapy.,0
"The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).",1
"The authors report a case of acute pancreatitis (AP) occurring in a patient under treatment with carbamazepine (CBZ) for post-traumatic petit mal epilepsy, and review the current literature of drug-induced AP.",1
Prior neurologic illness or CNS insult of any kind is known to increase the vulnerability to neurotoxicity of lithium.,1
"It generally is characterized by fever, altered mental status, rigidity, and autonomic dysfunction.",0
He now realised that he had eaten a chocolate cake before this episode and remembered that before the first episode he had had a chocolate mousse dessert.,0
2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.,1
A comorbid diagnosis of Parkinson's disease in schizophrenia was confirmed in this way.,0
"The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.",1
Drugs metabolized by the same enzyme may interact with each other.,0
"He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.",1
"On day 14, itraconazole solution at a dose of 5 mg/kg was begun.",0
A few cases of severe skin reactions such as toxic epidermal necrolysis have been reported.,0
The girl is alive 23 months after transplantation with complete donor chimerism; both Ph chromosome and bcr/abl RNA are negative.,0
We report a patient with AIDS and intestinal microsporidiosis.,0
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
"The alpha(1)-adrenoceptor occupancy by endogenous norepinephrine was increased in a dose-dependent manner by milnacipran, whereas fluvoxamine had essentially no effect.",0
We report a case of successful management of iatrogenic intravitreal triamcinolone acetonide for intermediate uveitis.,0
"OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.",1
This case report describes successful lithium treatment in a patient with long-standing periodic catatonia.,0
The treatment remains the removal of the offending stimulus along with drug therapy.,0
Histologic examination of biopsies from two regressing tumor nodes showed necrotic tumor cells and infiltration with CD8 positive cells.,0
"We describe a 65-year-old man with HIV who underwent a 12-hour intensive pharmacokinetic study while receiving esomeprazole with atazanavir-ritonavir and subsequently, an 8-hour study while receiving esomeprazole with fosamprenavir-ritonavir.",0
"CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.",1
"Seventeen days earlier, she had received a prescription for topical econazole lotion 1% to be applied 3 times daily for 1 month to treat a dermatitis affecting 12% of the body surface.",0
"Multiple periarticular abnormalities appearing on serial radionuclide bone scanning of the cancer patient, particularly when symmetric and in a distribution not suggestive of osseous metastatic disease, raise the possibility of multifocal osteonecrosis.",0
The next morning the woman was improved and informed clinicians of her desmopressin use.,0
The case emphasises that immune reconstitution can be an extremely aggressive complication of HAART.,0
Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.,1
"The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.",1
"In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",1
"RESULTS: Amino acid PET, performed when the lesions were still small, showed multiple small areas of mild uptake in close correlation to the MRI lesions.",0
"Pyomyositis is a rare disease, encountered mainly in tropical climates.",0
A 65-year-old man on warfarin therapy with a sudden spontaneous onset of sub-conjunctival haematoma associated with bloody tears was assessed in the clinic following a referral from an optometrist.,1
"We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium (Depakote), resulting in serum concentrations 10 times greater than the therapeutic range.",1
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.,1
"Drug-induced thrombocytopenia was also considered, and he was told to stop all of his medicines.",0
A 47-year-old woman with a history of breast cancer presented with eruptive cutaneous nodules on the trunk and extremities.,0
"We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).",1
"Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.",1
Two patients with HLH developed etoposide-related secondary acute myeloid leukemia (sAML) following therapy for HLH.,1
Gemcitabine-related radiation recall in a patient with pancreatic cancer.,1
"We report five paediatric cases of portal vein thrombosis (PVT) occurring during chemotherapy, observed in two institutions over an 8-year time period.",0
"Use of recombinant human hemopoietic colony-stimulating factor was reported to be of benefit in patients who developed agranulocytosis, although there is still some doubt regarding the efficacy in AA.",0
"In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.",1
Postoperative recovery was complicated by the development on day four of bilateral herpes zoster at the T8 dermatome level.,0
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.,1
Our patient's symptoms were resolved when tacrolimus was substituted for cyclosporine and amlodipine was initiated.,0
"With higher doses of radiation being given by using conformal techniques, more radiation-induced optic neuritis and neuropathy will be identified.",0
"The mother, applied hot compresses for 16 hours, starting 6.5 hours after the injection.",0
"Motor neuropathy, anemia and all gastrointestinal symptoms disappeared.",0
Primary CNS lymphoma regressed on withdrawal of MM.,1
We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.,1
Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity.,1
"Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.",1
"The condition is primarily reported in patients with end-stage renal disease, and is associated with significant morbidity and mortality.",0
"Though they are generally considered safe, there have been a few reports of myocardial infarction and stroke associated with triptan use.",1
Prior sexual profile included from no sexual outlet to hypersexuality.,0
"Since imiquimod induces large amounts of type I interferon production from TLR7-expressing plasmacytoid dendritic cell precursors (PDCs), the natural interferon-producing cells of the peripheral blood, we asked whether PDCs are present in psoriatic skin.",1
The drug was immediately withdrawn and the patient was given glibenclamide.,0
"Both patients were successfully treated by chemotherapy including all-trans retinoic acid (ATRA), and after reaching complete remission, they have subsequently been in continuous remission.",0
The therapeutic significance of increased Hb F levels in homozygous beta thalassemia and sickle cell anemia is exemplified.,0
Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.,1
Palpable purpuric skin lesions on the anterior surface of both legs appeared on the 55th day of amphotericin B treatment.,1
"The white matter was affected by severe myelin pallor, edema, and a prominent macrophage infiltrate in each of the cases.",0
Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.,1
"Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.",1
Three-quarters of the acute cases recovered with full occupation capacity.,0
Opioid-related narcosis is the most likely diagnosis in this case.,0
A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF.,1
"In addition, the response to a corticotropin stimulation test was abnormal, an indication of suppression of the adrenal glands.",0
"One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment, none of which was clinically significant.",1
Central venous catheter-related Rhodotorula rubra fungemia.,0
"Infliximab and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.",1
Recurrent hypotension immediately after seizures in nortriptyline overdose.,1
An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin.,1
"In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.",1
Retinal dysfunction and anterior segment deposits in a patient treated with rifabutin.,1
"One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.",1
DESIGN: Case report.,0
This organism has rapidly spread through many countries.,0
Three cases with touch of an intact anterior vitreous face to the cornea following phacoemulsification had moderate corneal edema.,0
Our results suggest that patients with CLL in whom AML/MDS develops have similar prognoses to other patients with AML/MDS.,0
Eight months after the initiation of therapy he developed fatigue and dyspnea on exertion.,0
"It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports; the rapid and lasting response to intravenous sodium bicarbonate; the absence of another etiology; normal serum potassium, chloride and bicarbonate despite continued spironolactone therapy after recovery.",1
Pancytopenia associated with 5-aminosalicylic acid use in a patient with Crohn's disease.,1
"When the seizures were controlled with midazolam, the hypotension subsided and norepinephrine was decreased.",0
"Risperidone appears effective in controlling agitation in patients with dementia and has a relatively benign adverse-effect profile, but more clinical trials are needed to elucidate its role for this indication.",0
"However, the clinical role of S-1 in patients with recurrent/metastatic head and neck cancer is still uncertain.",0
The apparent low adverse effect profile of the new drug zafirlukast has made it an attractive choice in the treatment of asthma.,0
"The potential for fomepizole to inhibit retinol dehydrogenase, an isoenzyme of alcohol dehydrogenase essential to vision, did not appear to be clinically significant in this symptomatic methanol-poisoned patient.",0
Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops.,1
CONCLUSION: Our PCR analysis showed the presence of CMV-DNA within the cornea of the patient with corneal endotheliitis.,0
Amphotericin B overdose in pediatric patients with associated cardiac arrest.,1
The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.,1
In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.,1
"Initial visual acuity was <20/800 (finger counting at 1-2 feet) with retinal edema on fundoscopy, arterial pH 7.19, methanol 97 mg/dL (30 mmol/L), formate 14.3 mmol/L, and ethanol undetectable.",0
The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.,1
The first patient was a 61-year-old man with a 30-year history of fistulizing CD in whom B-cell non-Hodgkin's lymphoma was diagnosed 9 months after treatment with infliximab.,1
This case highlights the need to monitor liver enzymes in patients treated with 6-TG and identifies the need for additional research focused on the mechanism of thiopurine-induced hepatic injury.,1
"BACKGROUND: Although multiple sclerosis (MS) is a common disease of the central nervous system, the association of intraparenchymal tumour has been rarely reported and the potential relationship between intracranial meningioma and MS has not been seriously analysed.",0
Nephrotic patients in endemic areas of Strongyloides infection should have the differential white cell count checked.,0
"In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.",1
"Their criticisms also differed from a third criticism contained in the article as well as the protocol being advocated in the article, thus contravening the claim that there is one prescribed protocol which must be followed.",0
"METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.",1
"She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.",1
"In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.",1
"CASE REPORT: This 36-year-old woman had rheumatoid arthritis that proved refractory to sulfasalazine and methotrexate, which were used successively in combination with symptomatic drugs.",0
We describe the case of a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance who developed a dramatic anaphylactic reaction to oral prednisone.,1
We followed bone marrow morphology in a 2-year-old male with HS who received up to 8 micrograms/kg GM-CSF per day because of failure of allogeneic bone marrow engraftment.,0
Chronic fentanyl application induces adrenocortical insufficiency.,1
"During that time,weight issues and diabetes status were not addressed.",0
"Even in a patient undergoing posterior lumbar interbody fusion using a metal cage, magnetic resonance imaging (MRI) might be able to diagnose epidural abscesses and diskitis when titanium alloy implants are used.",0
"To the best of our knowledge, this is the first case of lithium-associated CDI and NDI presenting concurrently.",1
He had developed postchemotherapy complications of possible cellulitis and necrotizing fasciitis that required wound debridement.,0
Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.,1
The case of a 65-year-old male migraine patient with spontaneous internal carotid artery dissection is presented.,0
"A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",1
CASE REPORT: We present a case of a 28-yr-old male who developed a severe case of nephrotic syndrome while being treated for relapsing/remitting Multiple Sclerosis (RRMS) with weekly injections of interferon beta 1a.,1
Emphasis is given to the differentiation of diphenylhydantoin induced gingival hyperplasia from the angiomatous enlargement of the gingiva before any treatment is planned.,1
Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.,1
Three of the seven patients were given a dosage of medication and exceeding the manufacture's recommendation.,0
"A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.",1
"At operation a black dacryolith was found, of the diameter predicted by ultrasound.",0
Malpractice actions against pediatricians treating patients with arrhythmias have been recurrent in four general areas.,0
"Fever, pulmonary infiltrates, and pleural effusion following acyclovir therapy for herpes zoster ophthalmicus.",1
"Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",1
Malignant lymphoma developed in the dorsum of the hand in a patient with a long-standing postmastectomy lymphedema.,0
"""St. Anthony's fire"" may be due to stimulation of alpha-adrenergic receptors in the peripheral vasculature.",0
"Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.",1
"In earlier studies, it was used on a daily schedule with resulting severe gastrointestinal toxicity and myelosuppression.",0
"As described in previous reports, the most common adverse effects are pain, inflammation, and induration at the injection site, occurring in approximately 20-60% of patients.",0
This is the first report to illustrate the implementation of an lndium (111) DTPA flow study without interrupting the infusion of CITB.,0
Rescue of haemopoiesis by a combination of growth factors including stem-cell factor.,0
We report the case of an iatrogenically immunosuppressed patient who presented with a massive upper gastrointestinal hemorrhage that was caused by Kaposi's sarcoma of the stomach.,0
"At the age of 14 months a diagnosis of congenital adrenal hyperplasia was made and treatment with dexamethasone (0.125 to 0.25 mg/day) resulted in a fall-off in growth rate, normal advancement in bone age, decrease in virilization and suppression of 17- ketosteroid excretion which continued until 4 3/12 years of age when virilization increased.",0
"Three patients who received more than 1100 mg/m2 developed pulmonary symptoms with the same clinical and radiologic pattern as in the two cases with pathologic documents, and two of them died from acute respiratory failure.",0
Possible reasons and clinical significance of this complication are discussed.,0
Rapid cycling in manic-depressives induced by tricyclic antidepressants.,0
Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia.,1
"Regarded as the most common and best understood of the hereditary periodic fever syndromes, familial Mediterranean fever (FMF) is a recessively inherited disease of episodic fever with some combination of severe abdominal pain, pleurisy, arthritis, and a characteristic ankle rash.",0
Deepening of lid sulcus from topical bimatoprost therapy.,1
Quetiapine-induced leucopenia and thrombocytopenia.,1
DESIGN: Retrospective interventional case series.,0
Aggressive management of doxorubicin-induced cardiomyopathy associated with 'low' doses of doxorubicin.,1
Inadvertent and accidental epinephrine overdose might result in potentially lethal complications.,1
We suggest that itraconazole should be added to the list of drugs that may be responsible for a drug-induced vanishing bile duct syndrome.,1
"Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.",1
"An 8-year-old boy, treated with a short course of steroids for asthma, developed a fever with abdominal pain and a generalized vesicular rash after contact with varicella-infected classmates.",0
The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.,1
A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.,1
"To our knowledge, this case is the first published report of levofloxacin-induced TEN.",1
A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis.,1
"The phenotype overlaps with that of attention deficit disorder, raising the possibility of subtypes of attention deficit disorder that have a peripheral sensory cause and novel forms of therapy.",0
They represented a typical picture of NE: two of them died because of septic shock; five patients had subileus with irritation of the peritoneum; and one had hepatosplenic abscesses confirmed 6 months later by post-mortem examination.,0
"The diagnosis was based on the rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy finding, following the administration of ampicillin.",1
"Trimethoprim-sulfamethoxazole, pseudomembranous colitis, and spinal cord injury.",0
This is probably the first case report of motile Enterococcus infection of the central nervous system.,0
We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.,1
"One explanation for the noted increase in the theophylline level is that metabolism occurs mainly by cytochrome P450 (CYP 1A2), an enzyme that is known to be inhibited with high concentrations of zafirlukast.",1
Back pain and opioid seeking behaviour.,0
"At three years progression free survival was 24% for the radiotherapy arm and 69% for the chemoradiotherapy group (P < 0.001), and three-year survival was 47% for the radiotherapy arm compared with 78% for the combined arm (P = 0.005).",0
"Pentavalent antimonial drugs used for the treatment of leishmaniasis have been associated with sudden deaths, probably due to the development of ventricular tachyarrhythmias.",0
"During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.",1
"To determine the effects of reversible medical castration on prostatic size in patients with benign prostatic hypertrophy (BPH), 3 patients with BPH were treated with a GnRH analogue, leuprolide, for six months at a dosage of .2ml (1 mg) s.c. daily.",0
"However, little is known about this complication immediately after vertebral artery stenting.",0
Drug-induced hepatotoxicity is an important cause of hepatocellular injury.,0
Immunological mechanisms are suggested in the pathogenesis of psoriasis and ulcerative colitis.,0
We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence.,1
We postulate that the bolus of sulprostone resulted in possible coronary spasm that resulted in cardiac arrest.,1
"Radiation recall from gemcitabine is rare, but can potentially arise in any site that has been previously irradiated.",1
OBJECTIVE: To report a case of phenolphthalein-induced toxic epidermal necrolysis (TEN) in a patient maintained on several other medications more commonly known to be associated with TEN.,1
Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.,1
CONCLUSION: Overnight wearing of a rigid contact lens is a risk factor for a corneal ulcer.,0
"The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.",1
He presented symptoms of hemiparesis 3 days after the operation.,0
"The cosmetic contact lens user should receive professional advice before accessing the lenses, and this must be communicated to the public.",0
Superior sagittal sinus thrombosis was demonstrated by cerebral angiogram.,0
Advantages of treatment of hypertension with Minoxidil.,0
This report describes 2 generations of a family with symptoms of sensory overstimulation that exhibit a potassium sensitivity similar to that seen in hypokalemic periodic paralysis.,0
The manifestations of delirium tremens persisted with titration of a lorazepam infusion in excess of 40 mg/hour.,0
"When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.",1
Both patients were successfully treated with propylthiouracil (PTU) and dexamethasone (DXT).,0
Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.,1
"Hypomagnesemia, hypokalemia, and hypocalcemia had developed.",0
"At the age of 12, a prematurely born boy with an otherwise unremarkable past medical history developed bilateral optic neuritis associated with transverse myelopathy.",0
"This patient, who had a history of osteoarthritis, had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints.",1
"In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.",1
"Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.",1
"Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.",1
Tumour necrosis factor-alpha inhibitors including infliximab are often used to treat a number of recalcitrant medical conditions.,0
Acute asthma associated with sustained-release verapamil.,1
All patients were under immunosuppressive therapy.,0
His symptoms of brain stem compression were alleviated and the role of phenytoin in the production of his craniocervical abnormality is discussed.,1
"Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.",1
RESULTS: The production of TNF-alpha and IL-6 by the macrophages of the patient in presence of insulin were dramatically increased in comparison with control subjects.,0
"Three such patients are described whose main features were uncontrolled seizures, progressive dementia, behaviour disorder, muscular pseudohypertrophy, and a relative paucity of localizing neurological signs or signs of raised intracranial pressure.",0
OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.,1
"Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.",1
Confocal microscopy findings of Acanthamoeba keratitis.,0
An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase.,1
Etoposide-related myocardial infarction.,1
Death occurred 4 to 16 weeks later.,0
"Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.",1
Migraine prevention.,0
It emphasizes the need for close surveillance of renal function and blood pressure during such therapy even in patients with relative preservation of renal function.,0
Ofloxacin: a probable cause of toxic epidermal necrolysis.,1
"CASE SUMMARY: A 75-year-old man developed agitation, confusion, incoordination, and gait disturbance because of progressive rigidity.",0
"Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.",1
"The patient was treated with polyhexamethylene biguanide and chlorhexidine for 3 months, and recovered with normal visual acuity.",0
We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine.,1
Neutropenic colitis during standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer.,1
"We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.",1
"A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.",1
"The administration of phenobarbital in this patient allowed improved symptom control, minimized the potential for propylene glycol toxicity, was not associated with respiratory depression, and facilitated successful weaning of benzodiazepines.",0
Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.,1
"Four months after treatment was initiated, there was no evidence of recurrent fungal keratitis or endophthalmitis.",0
The use of sodium thiosulfate seemed to be a reasonable nonspecific therapeutic approach for the management of TC in this case.,0
"After 2 weeks' off therapy, a partial reduction in mammary gland enlargement, local pain and erythema was observed.",0
"Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.",1
Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.,1
An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.,1
"During the past 10 y, 25 children with a mean age of 2 y were admitted for clonidine intoxication.",0
The case is reported of a 45-year-old woman who was being treated for chronic back and right leg pain with intrathecal morphine administered via a subcutaneous continuous-infusion device.,0
Hepatobiliary disorders associated with orally administered terbinafine have rarely been reported.,1
Coagulase-positive Staphylococcus aureus was cultured in the aspirate.,0
The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome.,1
We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).,1
"Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems.",1
Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine.,1
RESULTS: We measured the highest acyclovir serum levels reported so far (229.9 mumol/L = 51.8 mg/L).,0
"High plasma levels of N-desmethyl-clobazam (N-CLB), the major metabolite of CLB were detected.",0
"In view of our experience in the present case, it should be stressed that close monitoring of coagulation capacity is necessary in critically ill patients in order to avoid fatal haemorrhage after initiating warfarin therapy regardless of the dosage.",1
Two cases of therapeutic failure associated with levothyroxine brand interchange.,0
We describe a case of SCC in vitiligo lesion after long-term PUVA therapy.,0
Survival of patients with AL amyloidosis is no more than 1 to 2 years from the time of diagnosis with current management approaches.,0
We present a rare case of retinoid-induced sclerotic changes of lumbar spine and femur demonstrated by dual energy x-ray absorptiometrie (DEXA).,0
CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.,1
"A characteristic speech disorder, which may be described as cortical dysarthria or speech apraxia, occurs in approximately 1% of adults undergoing OLT.",0
Median time to progression (TTP) was 12 weeks.,0
"Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",1
The usefulness of CYP2C9 genotyping before starting coumarinic treatments is discussed.,0
"Although there is no rigorous evidence to support this management, private hyperbaric centers have been established throughout the United States and Canada.",0
Prosthetic valve endocarditis (PVE) due to Legionella micdadei was diagnosed in a man a year after valve replacement with a bovine xenograft.,0
"He subsequently had a resolution of all signs and symptoms, suggesting that these alarming events were a toxic but reversible side effect of the chemotherapy.",0
The patient had seronegative (rheumatoid factor negative) poliarticular form of JRA and was receiving low dose weekly Methotrexate (MTX) during the past 2 years.,0
"A 10-year-old female with atopic eczema developed eczema herpeticum after hot tub use with a friend who had ""fever blisters""; herpes simplex virus was recovered from cutaneous vesicles.",0
"CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.",1
The first signs of joint manifestations started one year after HIV seroconversion and resolved when antiviral treatment with AZT was started.,0
"Serious phenytoin hypersensitivity reactions may appear as dermatologic, lymphoid, or hepatic syndromes.",1
A potentially more common pharmacogenetic syndrome.,0
"The third patient, treated with 0.5 cc of thrombin, had an uneventful postoperative course.",0
"Aquagenic pruritus is a rare but distinct entity in which intense itching develops after contact with water, in the absence of cutaneous signs or underlying disorders that could explain the symptoms.",0
Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.,1
When not to use what.,0
"In the double-blind trial, 1 patient (12.5%) receiving rhEPO responded, as compared with no responses in the placebo group.",0
"This case, along with extensive reports in the medical literature, illustrate how treatment with inhibitors of TNF-alpha has the potential to result in a wide range of infectious complications, including rapid growing Mycobacterium.",0
"A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.",1
When they do occur they are rarely a clinical problem.,0
The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.,1
"Despite premedication with diphenhydramine and dexamethasone, she experienced generalized pruritus and urticaria, as well as headache and chest pain/tightness, after her next infusion.",0
OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.,1
The bleeding resolved on discontinuation of APV.,1
This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor.,1
We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.,1
"BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.",1
Administration of clonazepam reduced the frequency and amplitude.,0
"Fever, rash, and lymphadenopathy often accompany hepatic injury.",0
The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.,1
Hyponatraemia during low-dose carbamazepine therapy.,1
"The child, a 4-year-old boy, had unilateral retinoblastoma with metastatic spread to the central nervous system.",0
Possible mechanisms for this observation and clinical guidelines to identify patients at risk are suggested.,0
Further analysis of these cases suggests that the development of the ectopic ACTH syndrome may reflect changes in cell populations within the tumor and/or alterations in tumor behavior with time and perhaps with the effects of drug therapy.,0
Establishment of diuresis with fluids and IV administration of calcium may provide successful treatment of magnesium toxicosis in horses.,1
The nocturia was defined as having more than two episodes of urination during sleep per night on average.,0
The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement.,1
"CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",1
"Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.",1
EEG abnormalities were observed in two of the nine children during chlorambucil therapy.,1
Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.,1
"We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.",1
This is a case of pseudoephedrine-induced intracerebral hemorrhage in a patient with an underlying vascular malformation.,1
METHOD: Report of a case.,0