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"O",
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"O",
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"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T091",
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"O",
"B-T0... | [
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... | Parasitic infection as a potential therapeutic tool against rheumatoid arthritis Parasites, which are a recently discovered yet ancient dweller in human hosts, remain a great public health burden in underdeveloped countries, despite preventative efforts. Rheumatoid arthritis is a predominantly cosmopolitan health problem with drastic morbidity rates, although encouraging progress has been achieved regarding treatment. However, although various types of methods and agents have been applied clinically, their broad usage has been limited by their adverse effects and/or high costs. Sustained efforts have been exerted on the ' hygiene hypothesis ' since the 1870s. The immunosuppressive nature of parasitic infections may offer potential insight into therapeutic strategies for rheumatoid arthritis, in which the immune system is overactivated. An increasing number of published papers are focusing on the preventive and/or curative effect of various parasitic infection on rheumatoid arthritis from experimental studies to large-scale epidemiological studies and clinical trials. Therefore, the present review aimed to provide a general literature review on the possible beneficial role of parasitic infection on rheumatoid arthritis. |
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"O",
"O",
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"O",
"O",
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"B-T033",
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"B-T038",
"I-T038",
"O",
"O",
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"O",
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"I-T017",
"I-T017",
"I-T017",
"I-T017",
"I-T017",
"B-T204",
"O",
"O",
"O",
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"B-T038",
... | [
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{
"db_id": null,
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"db_id": "C0017391",
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{
"db_id": "C0017391",
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}... | [
"Diet",
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"induced",
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79,... | Diet - and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and Wnt Pathway in the Intestine of Apc(+/1638N) Mice: Comparisons and Contrasts Obesity is an established risk factor for colorectal cancer (CRC). Our previous study indicated that obesity increases activity of the pro-tumorigenic Wnt-signaling. Presently, we sought to further advance our understanding of the mechanisms by which obesity promotes CRC by examining associations between microbiome, inflammation and Wnt-signaling in Apc(+/1638N) mice whose obesity was induced by one of two modalities, diet - or genetically-induced obesity. Three groups were employed: Apc(+/1638N) Lepr(+/+) fed a low fat diet (10% fat), Apc(+/1638N) Lepr(+/+) fed a high fat diet (60% fat, diet - induced obesity), and Apc(+/1638N) Lepr(db/db) fed a low fat diet (genetically-induced obesity). All animals received diets for 16 weeks from 8 to 24 weeks of age. The abundance of 19 bowel cancer -associated bacterial taxa were examined by real-time PCR. The abundance of Turicibacter and Desulfovibrio decreased, but F. prausnitizii increased, in diet - induced obese mice (p < 0.05). In contrast, in genetically-induced obese mice, Bifidobacterium, A. muciniphila and E. rectale decreased, but Peptostrptococcus, and E. coli increased (p < 0.05). Both diet - and genetically-induced obesity altered the expression of genes involved in bacterial recognition (MyD88) and increased inflammation as indicated by elevated levels of cytokines (IFNγ and TNF-α for genetically-induced obesity, and IL-6 for diet - induced obesity). The elevated inflammation was associated with altered expression of genes that are integral components of the Wnt-signaling cascade in a fashion indicating its activation. These findings demonstrate that the composition of the small intestinal microbiome is affected differently in diet - and genetically-induced obesity, but both are associated with elevated intestinal inflammation and alterations of the Wnt pathway towards enhancing tumorigenesis. |
[
"B-T170",
"I-T170",
"I-T170",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"B-T... | [
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"db_id": "C0449475",
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{
"db_id": "C0449475",
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... | [
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... | Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy Transcriptome profiles derived from the site of human disease have led to the identification of genes that contribute to pathogenesis, yet the complex mixture of cell types in these lesions has been an obstacle for defining specific mechanisms. Leprosy provides an outstanding model to study host defense and pathogenesis in a human infectious disease, given its clinical spectrum, which interrelates with the host immunologic and pathologic responses. Here, we investigated gene expression profiles derived from skin lesions for each clinical subtype of leprosy, analyzing gene coexpression modules by cell-type deconvolution. In lesions from tuberculoid leprosy patients, those with the self-limited form of the disease, dendritic cells were linked with MMP12 as part of a tissue remodeling network that contributes to granuloma formation. In lesions from lepromatous leprosy patients, those with disseminated disease, macrophages were linked with a gene network that programs phagocytosis. In erythema nodosum leprosum, neutrophil and endothelial cell gene networks were identified as part of the vasculitis that results in tissue injury. The present integrated computational approach provides a systems approach toward identifying cell -defined functional networks that contribute to host defense and immunopathology at the site of human infectious disease. |
[
"B-T204",
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"O",
"O",
"O",
"B-T204",
"O",
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"O",
"O",
"B-T082",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O",
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"I-T170",
"O",
"O",
"O",
"O",
"B-T170",
"I-T170",
"I-T170",
"O",
"O",
"O",
"O",
"O",... | [
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... | [
"Lathrolestes",
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... | Lathrolestes Förster, 1869 (Hymenoptera, Ichneumonidae) from Brazil, with description of two new species and a key to the Neotropical species The taxonomic knowledge about Brazilian Ichneumonidae species is still incipient, especially for groups poorly represented in the Neotropics, like Ctenopelmatinae. The genus Lathrolestes Förster, 1869, mainly Holarctic, is here recorded for the first time to Brazil, with description of L. piranga Lima & Kumagai sp. n. and L. pitunauassu Lima & Kumagai sp. n. Additionally, a key to the Neotropical species is provided. |
[
"O",
"O",
"O",
"O",
"B-T033",
"O",
"B-T033",
"O",
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"B-T168",
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"O",
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"I-T168",
"O",
"O",
"B-T038",
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81... | Effect of acute heat stress and slaughter processing on poultry meat quality and postmortem carbohydrate metabolism This study investigated the effects of acute heat stress and slaughter processing on poultry meat quality and carbohydrate metabolism. Broilers (200) were randomly divided into 2 groups receiving heat stress (HS; 36°C for one h), compared to a non-stressed control (C). At slaughter, each group was further divided into 2 groups for slaughter processing (L = laboratory; F = commercial factory). L group breasts were removed immediately after bleeding without carcass scalding or defeathering, and stored at 4°C. F group broilers were scalded (60°C, 45 s) after bleeding and defeathering. Then the breasts were removed and cooled in ice water until the core temperature was ≤4°C. Rates of Pectoralis core temperature and pH decline were changed by slaughter processing, but only HS affected ultimate pH in group L. HS muscles had higher L * values (P < 0.05) than controls at 24 h postmortem. Laboratory processing " hot-deboning " increased drip loss, which resulted in a lower cooked loss (P < 0.05). Postmortem glycolysis was affected only by HS. The speed of lactic acid accumulation and glycogen degradation was faster in the HS group than controls at 5 min postmortem. During storage the glycolysis rates were not different (P > 0.05). Sarcoplasmic protein solubility was higher in F processed birds (P < 0.05). HS decreased the solubility of myofibrillar and total protein in the L - slaughtered birds. Thus, HS caused a higher frequency of accelerated muscle glycolysis than controls. Factory processing (chilling) could not completely eliminate the effects of accelerated glycolysis caused by pre- slaughter HS. |
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... | [
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... | Chronic Pseudomonas aeruginosa infection - induced chronic bronchitis and emphysematous changes in CCSP - deficient mice The club cell secretory protein (CCSP) is a regulator of lung inflammation following acute respiratory infection or lung injury. Recently, the relationship between CCSP and COPD has been reported. Since COPD results from an abnormal inflammatory response, we hypothesized that CCSP could have a protective role against chronic inflammation - induced lung damage. To address this issue, the pathophysiology of chronic lung inflammation induced by Pseudomonas aeruginosa in CCSP - deficient mice was determined. A tube of 5 mm in length was soaked in a fluid containing P. aeruginosa (PAO01 strain) for 1 week and inserted into the trachea of CCSP - deficient mice. One week later, P. aeruginosa was administered into the trachea. Five weeks after insertion of tube, the mice were sacrificed. Bronchoalveolar lavage fluids were collected to determine the bacterial growth, and the lung histology and physiology were also examined. P. aeruginosa was continuously detected in bronchoalveolar lavage fluids during the study. Neutrophils were increased in the bronchoalveolar lavage fluids from the CCSP - deficient mice in comparison to wild-type mice. A histological study demonstrated chronic inflammation around bronchus, serious bronchial stenosis, and alveolar enlargement in the CCSP - deficient mice. The lung physiology study demonstrated an increase in the lung compliance of the CCSP - deficient mice. Chronic P. aeruginosa inflammation resulted in chronic bronchitis and emphysematous changes in the CCSP - deficient mice. CCSP could play an important role in protecting the host from the chronic inflammation - induced lung damage. |
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"O",
"B-T082",
"I-T082",
"I-T082",
"O",
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"O",
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... | [
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"db_id": "C0679924",
"db_name": "U... | [
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9... | Job satisfaction among community pharmacy professionals in Mekelle city, Northern Ethiopia Job satisfaction is a multidimensional, enduring, important, and much - researched concept in the field of organizational behavior and has been identified as recognition in one's field of work, level of salary, opportunities for promotion, and achievement of personal goals. Job satisfaction directly affects the labor market behavior and economic efficiency by means of the impact on productivity and turnover of staff. The aim of this study was to assess the satisfaction level of pharmacy professionals in Mekelle city. This institution - based cross-sectional study was conducted as a survey and only included voluntary participants. Those participants who did not volunteer to participate were excluded from the study. A structured questionnaire was used as a data collection tool; it was developed from different literature in the English language, and then the original tool was translated to the local language for the purpose of understanding. In Mekelle, ~100 pharmacy professionals work in private medicine retail outlets. From those, only 60 volunteered to participate in this study. Significant difference in job satisfaction and job stress were observed between those working full-time and part-time, with P-values of 0.031 and 0.021, respectively. From the findings of the current study, it can be concluded that around two-thirds of pharmacy professionals in Mekelle city were satisfied with their professional practice. |
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75,... | The Role of Rehabilitation in the Management of Patients with Charcot-Marie-Tooth Disease: Report of Two Cases Charcot-Marie-Tooth (CMT) disease is a hereditary disease with signs of chronic non-progressive motor-sensory neuropathy which is characterised by symmetric muscle atrophy and weakness of the distal portion of lower extremities. The aim is to present two cases with peroneal muscular atrophy, applied rehabilitation procedures and rehabilitation outcome. Patient DR, aged 51, and patient KH, aged 78. Both patients had weakness and pronounced atrophy of the distal portion of lower extremities, numbness down the legs, contractures in the ankles and walking difficulties. Evaluation of patients included a clinical examination, Barthel Index, Time Up and Go test, measurement of the ankle range of motion, and a manual muscle test. On admission, the Barthel Index score was 60 in the first case, and 80 in the second. The rehabilitation program included exercise therapy with for lower extremity, occupational therapy, stationary bicycle riding, galvanic current, water exercises, and ankle-foot orthoses for both legs. The therapy applied had no significant changes in the clinical neurological status of the patients, but yet it provided some improvement in ankle contractures, better mobility, and a more stable gait. The application of rehabilitation procedures in patients with Charcot-Marie-Tooth disease can improve their functional status and walking stability. |
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... | Adjunctive aripiprazole in risperidone - induced hyperprolactinaemia: double-blind, randomised, placebo-controlled trial Hyperprolactinaemia is a troublesome side-effect of treatment with antipsychotics. This double-blind, placebo-controlled study aimed at examining the effect of adjunctive treatment with 10 mg aripiprazole on prolactin levels and sexual side-effects in patients with schizophrenia symptomatically maintained on risperidone. Thirty patients taking risperidone were enrolled into the trial (CTRI/2012/11/003114). Aripiprazole was administered at a fixed daily dose of 10 mg/day for 8 weeks. Serum prolactin was measured at baseline and at 8 weeks. Hyperprolactinaemia -related problems, psychopathology and side-effects were evaluated every 2 weeks. Prolactin levels decreased by 58% in the aripiprazole group compared with an increase by 22% in the placebo group. Prolactin levels normalised in 46% of patients in the aripiprazole group (number needed to treat, NNT=2). Aripiprazole improved erectile dysfunction in five out of six patients. There were no significant differences in change in psychopathology or side-effects between groups. Adjunctive aripiprazole reduced prolactin levels in those treated with risperidone, with no effect on psychopathology and extrapyramidal symptoms. This is a potential treatment for hyperprolactinaemia observed during treatment with second-generation antipsychotics. None. © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence. |
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... | Chemotherapy response and survival of inflammatory breast cancer by hormone receptor - and HER2 -defined molecular subtypes approximation: an analysis from the National Cancer Database To study the impact of hormone receptor (HR)- and human epidermal growth factor receptor 2 (HER2)-defined subtypes on survival of inflammatory breast cancer (IBC), and to determine whether sensitivity to neoadjuvant chemotherapy (NAC) varies with subtypes in a large IBC population. We analyzed 593 IBCs with known HR / HER2 statuses between 2010 and 2011 from National Cancer Database. We compared pathologic complete response (pCR) rates among four molecular subtypes by Chi-square test. Overall survival (OS) was compared among four subtypes and patients with or without pCR using log-rank test. Multivariate Cox model was performed to identify the impact of molecular subtype and other prognostic factors on OS. Of the 593 patients included, 231 (39.0 %) patients had HR+/HER2- tumors, 98 (16.5 %) had HR+/HER2+ disease, 112 (18.9 %) were HR-/HER2 + patients, and 152 (25.6 %) had triple-negative subtype. The pCR rates differed significantly by subtype (P < 0.001): HR-/HER2+ showed the highest, and HR+/HER2- exhibited the lowest. Multivariate analysis showed that triple-negative and HR+/HER2- IBCs had significantly worse survival compared with HR+/HER2+ or HR-/HER2+ subtype (P < 0.01 for all comparisons). Additional factors associated with worse OS included more comorbidities, lack or incomplete surgical resection, absence of radiotherapy, lack of hormone therapy, and more advanced stage. IBC is an aggressive heterogeneous disease with distinct molecular subtypes associated with differential outcomes and sensitivities to NAC. Unlike in noninflammatory breast cancer, in IBC HR + disease was not associated with favorable prognosis. Triple-negative and HR+/HER2- subtypes are independent predictors for suboptimal OS in IBC. |
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7... | High School CPR / AED Training in Washington State Describe the rates of CPR / AED training in high schools in the state of Washington after passage of legislation mandating CPR / AED training. A web -based survey was sent to administrators at 660 public and private high schools in the state of Washington. The survey was completed by 148 schools (22%); 64% reported providing CPR training and 54% provided AED training. Reported barriers to implementation included instructor availability, cost, and a lack of equipment. Descriptive statistics were used to describe the sample characteristics and implementation rates. Mandates without resources and support do not ensure implementation of CPR / AED training in high schools. Full public health benefits of a CPR mandate will not be realized until barriers to implementation are identified and eliminated through use of available, accessible public health resources. |
[
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"O",
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8... | Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country An active search for Mycobacterium leprae drug resistance was carried out, 243 multibacillary patients from endemic regions of Colombia were included from 2004 to 2013 in a surveillance program. This program was a World Health Organization initiative for drug resistance surveillance in leprosy, where Colombia is a sentinel country. M. leprae DNA from slit skin smear and/or skin biopsy samples was amplified and sequenced to identify mutations in the drug resistance determining region (DRDR) in rpoB, folP1, gyrA, and gyrB, the genes responsible for rifampicin, dapsone and ofloxacin drug-resistance, respectively. Three isolates exhibited mutations in the DRDR rpoB gene (Asp441Tyr, Ser456Leu, Ser458Met), two in the DRDR folP1 gene (Thr53Ala, Pro55Leu), and one isolate exhibited mutations in both DRDR rpoB (Ser456Met) and DRDR folP1 (Pro55Leu), suggesting multidrug resistance. One isolate had a double mutation in folP1 (Thr53Ala and Thr88Pro). Also, we detected mutations outside of DRDR that required in vivo evaluation of their association or not with drug resistance: rpoB Arg505Trp, folP1 Asp91His, Arg94Trp, and Thr88Pro, and gyrA Ala107Leu. Seventy percent of M. leprae mutations were related to drug resistance and were isolated from relapsed patients; the likelihood of relapse was significantly associated with the presence of confirmed resistance mutations (OR range 20.1-88.7, p < 0.05). Five of these relapsed patients received dapsone monotherapy as a primary treatment. In summary, the current study calls attention to M. leprae resistance in Colombia, especially the significant association between confirmed resistance mutations and relapse in leprosy patients. A high frequency of DRDR mutations for rifampicin was seen in a region where dapsone monotherapy was used extensively. |
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"O",
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"O",
"O",
"O",
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"O",
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... | [
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8... | DNA barcoding and phylogenetic relationships of Ardeidae (Aves: Ciconiiformes) The avian family Ardeidae comprises long-legged freshwater and coastal birds. There has been considerable disagreement concerning the intrafamilial relationships of Ardeidae. Mitochondrial cytochrome c oxidase subunit I (COI) was used as a marker for the identification and phylogenetic analysis of avian species. In the present study, we analyzed the COI barcodes of 32 species from 17 genera belonging to the family Ardeidae. Each bird species possessed a barcode distinct from that of other bird species except for Egretta thula and E. garzetta, which shared one barcoding sequence. Kimura two-parameter distances were calculated between barcodes. The average genetic distance between species was 34-fold higher than the average genetic distance within species. Neighbor - joining and maximum likelihood methods were used to construct phylogenetic trees. Most species could be discriminated by their distinct clades in the phylogenetic tree. Both methods of phylogenetic reconstruction suggested that Zebrilus, Tigrisoma, and Cochlearius were an offshoot of the primitive herons. COI gene analysis suggested that the other herons could be divided into two clades: Botaurinae and Ardeinae. Our results support the Great Egret and Intermediate Egret being in separate genera, Casmerodius and Mesophoyx, respectively. |
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... | [
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... | [
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... | Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorphisms (C677T and A1298C) and breast cancer (BC) chemotherapy response. From February 2013 to January 2016, 148 advanced BC patients at the Center Hospital of Cangzhou were enrolled and treated with six different chemotherapy regimens. Subjects were genotyped using polymerase chain reaction - restriction fragment length polymorphism. Forty-one (27.7%), 70 (47.3%), and 37 (25.0%) patients carried the C/C, C/T, and T/T C677T genotypes, respectively; 101 (68.2%), 42 (28.4%), and 5 (3.4%) had the A/A, A/C, and C/C genotypes of A1298C, respectively. Total chemotherapy efficacy was 66.9% (99/148), with 7 (4.7%), 92 (62.2%), 36 (24.3%), and 13 (8.8%) cases showing complete response, partial response, no change, and progressive disease, respectively. Chemotherapy regimens did not differ in effectiveness (P > 0.05). Efficacy rates associated with C677T C/C, C/T, and T/T genotypes were 58.5, 58.6, and 91.9%, respectively, with T/T carriers exhibiting significantly better responses than the C/C (P < 0.05) and C/T groups (P < 0.05). Effectiveness among A1298C A/A, A/C, and C/C carriers was 70.6, 64.3, and 0.0%, respectively, but no difference was established between these genotypes in this regard (P > 0.05). The MTHFR C677T genotype may be associated with BC chemotherapy response, and could be of great value in guiding individualized treatment for this disease. |
[
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6... | Making extra teeth: Lessons from a TRPS1 mutation A Thai mother and her two daughters were affected with tricho-rhino-phalangeal syndrome type I. The daughters had 15 and 18 supernumerary teeth, respectively. The mother had normal dentition. Mutation analysis of TRPS1 showed a novel heterozygous c.3809_3811del ACTinsCATGTTGTG mutation in all. This mutation is predicted to cause amino acid changes in the Ikaros-like zinc finger domain near the C-terminal end of TRPS1, which is important for repressive protein function. The results of our study and the comprehensive review of the literature show that pathways of forming supernumerary teeth appear to involve APC and RUNX2, the genes responsible for familial adenomatous polyposis syndrome and cleidocranial dysplasia, respectively. The final pathway resulting in supernumerary teeth seems to involve Wnt, a morphogen active during many stages of development. © 2016 Wiley Periodicals, Inc. |
[
"B-T204",
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"O",
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"B-T204",
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"O",
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"O",
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"B-T098",
"I-T098"... | [
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{
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"three",
"decades",
"Toxoplasma",
"gondii",
"is",
"an",
"obligate",
"intracellular",
"protozoan",
"... | [
[
0,
10
],
[
11,
17
],
[
18,
32
],
[
33,
35
],
[
36,
39
],
[
40,
50
],
[
51,
61
],
[
61,
62
],
[
63,
73
],
[
74,
76
],
[
77,
82
],
[
83,
88
],
[
88,
89
],
[
... | Toxoplasma gondii seroprevalence in the Portuguese population: comparison of three cross-sectional studies spanning three decades Toxoplasma gondii is an obligate intracellular protozoan infecting up to one-third of the world's population, constituting a life threat if transmitted from mother to child during pregnancy. In Portugal, there is a lack of knowledge of the current epidemiological situation, as the unique toxoplasmosis National Serological Survey was performed in 1979/1980. We studied the seroprevalence trends in the Portuguese general population over the past 3 decades, by assessing chronological spread cross-sectional studies, with special focus on women of childbearing age, by age group, region and gender. The T. gondii overall seroprevalence decreased from 47% in 1979/1980 to 22% (95% CI 20% to 24%) in 2013. Generally, we observed that the prevalence of T. gondii IgG increased significantly with age and it decreased over time, both in the general population and in the childbearing women (18% prevalence in 2013). The scenario observed for the latter indicates that more than 80% of childbearing women are susceptible to primary infection yielding a risk of congenital toxoplasmosis and respective sequelae. Since there is no vaccine to prevent human toxoplasmosis, the improvement of primary prevention constitutes a major tool to avoid infection in such susceptible groups. |
[
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038... | [
{
"db_id": null,
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},
{
"db_id": null,
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{
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"db_id": "C0019247",
"db_name": "UMLS"
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{
"db_id": "C001... | [
"The",
"presence",
"of",
"two",
"rare",
"genomic",
"syndromes",
",",
"1q21",
"deletion",
"and",
"Xq28",
"duplication",
",",
"segregating",
"independently",
"in",
"a",
"family",
"with",
"intellectual",
"disability",
"1q21",
"microdeletion",
"syndrome",
"is",
"a",
... | [
[
0,
3
],
[
4,
12
],
[
13,
15
],
[
16,
19
],
[
20,
24
],
[
25,
32
],
[
33,
42
],
[
42,
43
],
[
44,
48
],
[
49,
57
],
[
58,
61
],
[
62,
66
],
[
67,
78
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7... | The presence of two rare genomic syndromes, 1q21 deletion and Xq28 duplication, segregating independently in a family with intellectual disability 1q21 microdeletion syndrome is a rare contiguous gene deletion disorder with de novo or autosomal dominant inheritance patterns and its phenotypic features include intellectual disability, distinctive facial dysmorphism, microcephaly, cardiac abnormalities, and cataracts. MECP2 duplication syndrome is an X-linked recessive neurodevelopmental disorder characterized by intellectual disability, global developmental delay, and other neurological complications including late-onset seizures. Previously, these two different genetic syndromes have not been reported segregating independently in a same family. Here we describe two siblings carrying either a chromosome 1q21 microdeletion or a chromosome Xq28 duplication. Using a comparative genomic hybridization (CGH) array, we identified a 1.24 Mb heterozygous deletion at 1q21 resulting in the loss of 9 genes in a girl with learning disability, hypothyroidism, short stature, sensory integration disorder, and soft dysmorphic features including cupped ears and a unilateral ear pit. We also characterized a 508 kb Xq28 duplication encompassing MECP2 in her younger brother with hypotonia, poor speech, cognitive and motor impairment. The parental CGH and quantitative PCR (qPCR) analyses revealed that the 1q21 deletion in the elder sister is de novo, but the Xq28 duplication in the younger brother was originally inherited from the maternal grandmother through the mother, both of whom are asymptomatic carriers. RT-qPCR assays revealed that the affected brother has almost double the amount of MECP2 mRNA expression compared to other family members of both genders including maternal grandmother and mother who have the same Xq28 duplication with no phenotype. This suggests the X chromosome with an Xq28 duplication in the carrier females is preferentially silenced. From our understanding, this would be the first report showing the independent segregation of two genetically unrelated syndromes, 1q21 microdeletion and Xq28 duplication, in a same family, especially in siblings. Although these two chromosomal abnormalities share some similar phenotypes such as intellectual disability, mild dysmorphic features, and cardiac abnormalities, the presence of two unrelated and rare syndromes in siblings is very unusual. Therefore, further comprehensive investigations in similar cases are required for future studies. |
[
"O",
"O",
"O",
"B-T037",
"I-T037",
"O",
"B-T017",
"I-T017",
"B-T038",
"O",
"B-T038",
"I-T038",
"O",
"B-T017",
"I-T017",
"B-T037",
"I-T037",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"B-T017",
"I-T017",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": "C0282507",
"db_name": "UMLS"
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{
"db_id": "C0282507",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id... | [
"Effects",
"of",
"chronic",
"heat",
"stress",
"on",
"granulosa",
"cell",
"apoptosis",
"and",
"follicular",
"atresia",
"in",
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"ovary",
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"stress",
"is",
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"to",
"alter",
"follicular",
"dynamics",
"and",
"granulosa",
"cell",
"cell",
"function"... | [
[
0,
7
],
[
8,
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],
[
11,
18
],
[
19,
23
],
[
24,
30
],
[
31,
33
],
[
34,
43
],
[
44,
48
],
[
49,
58
],
[
59,
62
],
[
63,
73
],
[
74,
81
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[
82,
84
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8... | Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary Heat stress is known to alter follicular dynamics and granulosa cell function and may contribute to the diminished reproductive efficiency commonly observed in mammals during the summer. Although several investigators have studied heat-induced ovarian injury, few reports have focused on the effects of chronic heat stress on ovarian function and the molecular mechanisms through which it induces ovarian injury. In Exp. 1, 48 female mice were assigned to a control or heat-stressed treatment. After exposure to a constant temperature of 25 °C for 7, 14, 21 or 28 d (n = 6) or to 42 °C for 3 h per d for 7, 14, 21 or 28 d (n = 6), the mice were euthanized and their ovaries were analyzed for follicular atresia, granulosa cell apoptosis, changes in the abundance of HSP70 protein and serum concentrations of estradiol. In Exp. 2, the expression of HSP70 and aromatase was quantified in antral follicles cultured in vitro at 37 or 42 °C for 24 h. In Exp. 3, granulosa cells from ovaries maintained at 37 or 41 °C for 2 h were analyzed for their expression of HSP70, Bim, caspase-3 and cleaved caspase-3. In Exp. 1, body weight and food intake of heat-stressed mice decreased (P < 0.05) compared with control mice while the concentration of estradiol in serum was lower (P < 0.05) in heat-stressed mice than in control mice. Compared with control mice, the percentage of atretic follicles and the number of antral follicles with severe apoptotic signals were increased (P < 0.05) after 21 d of heat-stressed treatment. HSP70 protein was more abundant (P < 0.05) in heat-stressed mice than control mice. In Exp. 2, heat stress increased HSP70 and decreased aromatase proteins (P < 0.05) in antral follicles. In Exp. 3, TUNEL -positive granulosa cells from heat-stressed ovaries were observed concomitant with a significant increase in HSP70, Bim and cleaved caspase-3 protein. Heat-stress in mice decrease estradiol in serum and aromatase in antral follicles but increased number of atretic follicles and granulosa cell undergoing apoptosis which may explain the decreased fertility commonly observed in heat-stressed animals. |
[
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"B-T097",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
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{
"db_id": null,
"db_name": null
},
{
"db_id": "C3494292",
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{
"db_id": "C3494292",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id... | [
"Managing",
"perturbations",
"during",
"handover",
"meetings",
":",
"a",
"joint",
"activity",
"framework",
"To",
"document",
"the",
"prevalence",
"of",
"perturbations",
"of",
"handover",
"meetings",
"and",
"understand",
"how",
"nurses",
"manage",
"temporal",
",",
... | [
[
0,
8
],
[
9,
22
],
[
23,
29
],
[
30,
38
],
[
39,
47
],
[
47,
48
],
[
49,
50
],
[
51,
56
],
[
57,
65
],
[
66,
75
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[
76,
78
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[
79,
87
],
[
88,
91
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[
9... | Managing perturbations during handover meetings: a joint activity framework To document the prevalence of perturbations of handover meetings and understand how nurses manage temporal, physical and social meeting boundaries in response to perturbations. Handovers are joint activities performed collaboratively by participating nurses. Perturbations of handover are frequent and may potentially threaten continuity of care. We observed and videotaped handovers during five successive days in four nursing care units in two Swiss hospitals in 2009. Videorecordings were transcribed. All perturbations during the handovers were noted. We performed content analysis of the sources of perturbations from the notes and interactional micro-analyses of handover interactions based on video and transcripts. Nurses are the most frequent sources of perturbations during handovers. Perturbations are collaboratively managed. A tacit division of labour is enacted via multimodal communication strategies, whereby perturbations are dealt with using both linguistic and bodily signals. |
[
"O",
"B-T170",
"I-T170",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"I-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1551341",
"db_name": "UMLS"
},
{
"db_id": "C1551341",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"PDTRT",
"special",
"section",
":",
"Current",
"trends",
"in",
"borderline",
"personality",
"disorder",
"research",
"One",
"of",
"the",
"enjoyable",
"benefits",
"of",
"being",
"an",
"editor",
"of",
"a",
"journal",
"is",
"the",
"ability",
"to",
"develop",
"spec... | [
[
0,
5
],
[
6,
13
],
[
14,
21
],
[
21,
22
],
[
23,
30
],
[
31,
37
],
[
38,
40
],
[
41,
51
],
[
52,
63
],
[
64,
72
],
[
73,
81
],
[
82,
85
],
[
86,
88
],
[
8... | PDTRT special section: Current trends in borderline personality disorder research One of the enjoyable benefits of being an editor of a journal is the ability to develop special sections. It is evident simply from a perusal of a typical issue of Personality Disorders: Theory, Research, and Treatment (PDTRT) that a common focus of research is borderline personality disorder (BPD). BPD is among, if not the, most heavily researched personality disorder. It is only natural to have the first special section within my tenure as editor concern this personality disorder. Provided within this special section are review papers of current trends in BPD research by young (at least compared to me), leading, and innovative BPD researchers. (PsycINFO Database Record |
[
"B-T103",
"I-T103",
"O",
"O",
"O",
"B-T017",
"B-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"B-T017",
"O",
"B-T204",
"B-T017",
"B-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"B-T017",
"O",
"O",... | [
{
"db_id": "C0010804",
"db_name": "UMLS"
},
{
"db_id": "C0010804",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0033572",
"db_name": "UMLS"
},
{
... | [
"Keratin",
"13",
"Is",
"Enriched",
"in",
"Prostate",
"Tubule",
"-",
"Initiating",
"Cells",
"and",
"May",
"Identify",
"Primary",
"Prostate",
"Tumors",
"that",
"Metastasize",
"to",
"the",
"Bone",
"Benign",
"human",
"prostate",
"tubule",
"-",
"initiating",
"cells",... | [
[
0,
7
],
[
8,
10
],
[
11,
13
],
[
14,
22
],
[
23,
25
],
[
26,
34
],
[
35,
41
],
[
41,
42
],
[
42,
52
],
[
53,
58
],
[
59,
62
],
[
63,
66
],
[
67,
75
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[
7... | Keratin 13 Is Enriched in Prostate Tubule-Initiating Cells and May Identify Primary Prostate Tumors that Metastasize to the Bone Benign human prostate tubule-initiating cells (TIC) and aggressive prostate cancer display common traits, including tolerance of low androgen levels, resistance to apoptosis, and microenvironment interactions that drive epithelial budding and outgrowth. TIC can be distinguished from epithelial and stromal cells that comprise prostate tissue via cell sorting based upon Epcam, CD44, and CD49f antigenic profiles. Fetal prostate epithelial cells (FC) possess a similar antigenic profile to adult TIC and are capable of inducing tubule formation. To identify the TIC niche in human prostate tissue, differential keratin (KRT) expression was evaluated. Gene expression data generated from Affymetrix Gene Chip human U133 Plus 2.0 array of sorted adult and fetal epithelial cells revealed KRT13 to be significantly enriched in FC and TIC compared to basal cells (BC) and luminal cells (LC) (p<0.001). Enriched KRT13 expression was confirmed by RT-PCR and cytospin immunostaining. Immunohistochemical analysis of KRT13 expression revealed rare KRT13+ epithelia throughout prostatic ducts / acini in adult tissue specimens and differentiated tubules in 24- week recombinant grafts, In contrast, abundant KRT13 expression was observed in developing ducts / acini in fetal prostate and cord-like structures composing 8- week recombinant grafts. Immunostaining of a prostate tissue microarray revealed KRT13+ tumor foci in approximately 9% of cases, and this subset displayed significantly shorter time to recurrence (p = 0.031), metastases (p = 0.032), and decreased overall survival (p = 0.004). Diagnostic prostate needle biopsies (PNBX) from untreated patients with concurrent bone metastases (clinical stage M1) displayed KRT13+ tumor foci, as did bone metastatic foci. The expression profile of KRT13 in benign fetal and adult prostate tissue and in recombinant grafts, as well as the frequency of KRT13 expression in primary and metastatic prostate cancer indicates that it may be a marker of a stem/progenitor-like cell state that is co-opted in aggressive tumor cells. KRT13 is enriched in benign stem-like cells that display androgen - resistance, apoptosis - resistance, and branching morphogenesis properties. Collectively our data demonstrate that KRT13 expression is associated with poor prognosis at multiple stages of disease progression and may represent an important biomarker of adverse outcome in patients with prostate cancer. |
[
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T091",
"B-T033",
"O",
"B-T058",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T091",
"O",
"B-T033",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"... | [
{
"db_id": "C4275242",
"db_name": "UMLS"
},
{
"db_id": "C4275242",
"db_name": "UMLS"
},
{
"db_id": "C4275242",
"db_name": "UMLS"
},
{
"db_id": "C4275242",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
}... | [
"Sudden",
"sensorineural",
"hearing",
"loss",
":",
"is",
"there",
"a",
"relationship",
"between",
"routine",
"haematological",
"parameters",
"and",
"audiogram",
"shapes",
"?",
"To",
"investigate",
"the",
"relationship",
"between",
"haematological",
"routine",
"paramet... | [
[
0,
6
],
[
7,
20
],
[
21,
28
],
[
29,
33
],
[
33,
34
],
[
35,
37
],
[
38,
43
],
[
44,
45
],
[
46,
58
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[
59,
66
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[
67,
74
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[
75,
89
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[
90,
100
],
[
... | Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes? To investigate the relationship between haematological routine parameters and audiogram shapes in patients affected by sudden sensorineural hearing loss (SSNHL). A retrospective study. All patients were divided into four groups according to the audiometric curve and mean values of haematological parameters (haemoglobin, white blood cell, neutrophils and lymphocytes relative count, platelet count, haematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen and neutrophil-to-lymphocite ratio) of each group were statistically compared. The prognostic role of blood profile and coagulation test was also examined. A cohort of 183 SSNHL patients without comorbidities. With a 48.78% of complete hearing recovery, individuals affected by upsloping hearing loss presented a better prognosis instead of flat (18.36%), downsloping (19.23%) and anacusis (2.45%) groups (p = 0.0001). The multivariate analysis of complete blood count values revealed lower mean percentage of lymphocytes (p = 0.041) and higher platelet levels (p = 0.015) in case of downsloping hearing loss; with the exception of fibrinogen (p = 0.041), none of the main haematological parameters studied resulted associated with poorer prognosis. Our work suggested a lack of association between haematological parameters and a defined audiometric picture in SSNHL patients; furthermore, only fibrinogen seems to influence the prognosis of this disease. |
[
"B-T103",
"B-T038",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"B-T033",
"O",
"B-T038",
"I-T038",
"B-T017",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",... | [
{
"db_id": "C2975187",
"db_name": "UMLS"
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{
"db_id": "C1514559",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id... | [
"TIPE2",
"Overexpression",
"Suppresses",
"the",
"Proliferation",
",",
"Migration",
",",
"and",
"Invasion",
"in",
"Prostate",
"Cancer",
"Cells",
"by",
"Inhibiting",
"PI3K",
"/",
"Akt",
"Signaling",
"Pathway",
"Tumor",
"necrosis",
"factor",
"-",
"α",
"(",
"TNF",
... | [
[
0,
5
],
[
6,
20
],
[
21,
31
],
[
32,
35
],
[
36,
49
],
[
49,
50
],
[
51,
60
],
[
60,
61
],
[
62,
65
],
[
66,
74
],
[
75,
77
],
[
78,
86
],
[
87,
93
],
[
9... | TIPE2 Overexpression Suppresses the Proliferation, Migration, and Invasion in Prostate Cancer Cells by Inhibiting PI3K/Akt Signaling Pathway Tumor necrosis factor-α (TNF-α)-induced protein 8-like 2 (TNFAIP8L2, TIPE2) is involved in the invasion and metastasis of human tumors. However, the functional role of TIPE2 in prostate cancer remains unclear. In the present study, we explored the role of TIPE2 in prostate cancer and cancer progression including the molecular mechanism that drives TIPE2 -mediated oncogenesis. Our results showed that TIPE2 was lowly expressed in human prostate cancer tissues and cell lines. In addition, restored TIPE2 obviously inhibits proliferation in prostate cancer cells. TIPE2 overexpression also suppresses the epithelial-mesenchymal transition (EMT) process and migration / invasion in prostate cancer cells. Mechanistically, TIPE2 overexpression obviously inhibits the phosphorylation levels of phosphatidylinositol 3-kinase (PI3K) and Akt in prostate cancer cells. In conclusion, for the first time we demonstrated that TIPE2 overexpression may suppress proliferation, migration, and invasion in prostate cancer cells by inhibiting the PI3K/Akt signaling pathway. Therefore, TIPE2 might serve as a potential therapeutic target for human prostate cancer. |
[
"B-T033",
"B-T103",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"B-T058",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"B-T091",
"I-T091",
"I-T091",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"B-T058",
"O",
"O"... | [
{
"db_id": "C0205161",
"db_name": "UMLS"
},
{
"db_id": "C0051755",
"db_name": "UMLS"
},
{
"db_id": "C1171362",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0699791",
"db_name": "UMLS"
}... | [
"Abnormal",
"amphiregulin",
"expression",
"correlates",
"with",
"gastric",
"cancer",
"prognosis",
"Gastric",
"cancer",
"(",
"GC",
")",
"is",
"a",
"global",
"health",
"issue",
"with",
"a",
"high",
"mortality",
"rate",
".",
"Early",
"diagnosis",
"and",
"tracking",... | [
[
0,
8
],
[
9,
21
],
[
22,
32
],
[
33,
43
],
[
44,
48
],
[
49,
56
],
[
57,
63
],
[
64,
73
],
[
74,
81
],
[
82,
88
],
[
89,
90
],
[
90,
92
],
[
92,
93
],
[
9... | Abnormal amphiregulin expression correlates with gastric cancer prognosis Gastric cancer (GC) is a global health issue with a high mortality rate. Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of EGF receptors. Elevated AREG expression is associated with various pathological conditions, including cancer. Here, we investigated whether increased AREG expression is a disease indicator and/or prognostic biomarker for GC. We used tissue microarray and quantitative real-time polymerase chain reaction to assess AREG expression in clinical tissue specimens at various stages of GC and a conducted bioinformatics analysis to evaluate the value of AREG over-expression as a GC biomarker. We found that both mRNA and protein expression of AREG were increased in the tissues of GC patients when compared to tissues from non-cancer patients or normal tissues. High expression of AREG was also associated with GC clinicopathological characteristics and poor survival. Thus, over-expression of AREG could serve as a novel GC biomarker, and active surveillance of its expression could be a novel approach to GC diagnosis and monitoring. |
[
"B-T082",
"B-T033",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"B-T082",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"B-T074",
"I-T074",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C0332479",
"db_name": "UMLS"
},
{
"db_id": "C0243095",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0597177",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Shape",
"oscillations",
"of",
"particle",
"-",
"coated",
"bubbles",
"and",
"directional",
"particle",
"expulsion",
"Bubbles",
"stabilised",
"by",
"colloidal",
"particles",
"can",
"find",
"applications",
"in",
"advanced",
"materials",
",",
"catalysis",
"and",
"drug"... | [
[
0,
5
],
[
6,
18
],
[
19,
21
],
[
22,
30
],
[
31,
32
],
[
33,
39
],
[
40,
47
],
[
48,
51
],
[
52,
63
],
[
64,
72
],
[
73,
82
],
[
83,
90
],
[
91,
101
],
[
... | Shape oscillations of particle - coated bubbles and directional particle expulsion Bubbles stabilised by colloidal particles can find applications in advanced materials, catalysis and drug delivery. For applications in controlled release, it is desirable to remove the particles from the interface in a programmable fashion. We have previously shown that ultrasound waves excite volumetric oscillations of particle - coated bubbles, resulting in precisely timed particle expulsion due to interface compression on a ultrafast timescale [Poulichet et al., Proc. Natl. Acad. Sci. U. S. A., 2015, 112, 5932]. We also observed shape oscillations, which were found to drive directional particle expulsion from the antinodes of the non-spherical deformation. In this paper we investigate the mechanisms leading to directional particle expulsion during shape oscillations of particle - coated bubbles driven by ultrasound at 40 kHz. We perform high-speed visualisation of the interface shape and of the particle distribution during ultrafast deformation at a rate of up to 10(4) s(-1). The mode of shape oscillations is found to not depend on the bubble size, in contrast with what has been reported for uncoated bubbles. A decomposition of the non-spherical shape in spatial Fourier modes reveals that the interplay of different modes determines the locations of particle expulsion. The n-fold symmetry of the dominant mode does not always lead to desorption from all 2n antinodes, but only those where there is favourable alignment with the sub-dominant modes. Desorption from the antinodes of the shape oscillations is due to different, concurrent mechanisms. The radial acceleration of the interface at the antinodes can be up to 10(5)-10(6) ms(-2), hence there is a contribution from the inertia of the particles localised at the antinodes. In addition, we found that particles migrate to the antinodes of the shape oscillation, thereby enhancing the contribution from the surface pressure in the monolayer. |
[
"O",
"O",
"B-T058",
"B-T058",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"B-T038",
"I-T03... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0879464",
"db_name": "UMLS"
},
{
"db_id": "C3665472",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Comparison",
"of",
"FOLFIRINOX",
"Chemotherapy",
"with",
"Other",
"Regimens",
"in",
"Patients",
"with",
"Biliary",
"Tract",
"Cancers",
":",
"a",
"Retrospective",
"Study",
"The",
"aim",
"of",
"this",
"retrospective",
"study",
"was",
"to",
"compare",
"the",
"diff... | [
[
0,
10
],
[
11,
13
],
[
14,
24
],
[
25,
37
],
[
38,
42
],
[
43,
48
],
[
49,
57
],
[
58,
60
],
[
61,
69
],
[
70,
74
],
[
75,
82
],
[
83,
88
],
[
89,
96
],
[
... | Comparison of FOLFIRINOX Chemotherapy with Other Regimens in Patients with Biliary Tract Cancers: a Retrospective Study The aim of this retrospective study was to compare the different treatment options of patients with advanced biliary tract carcinoma (BTC) who were treated with platinum - gemcitabine (CG) or platinum -5- fluorouracil (CF) or 5-Fluorouracil-oxaliplatin-irinotecan (FOLFIRINOX) chemotherapy. We included the patients with advanced BTC who were registered at the Department of Oncology in Gaziantep University between January 2008 and January 2016. The following data were analyzed: disease control rate (DCR), progression free survival (PFS) of first and second-line of chemotherapy, and overall survival (OS). Kaplan-Meier method and Log-rank test was used to compare two survival curves, and hazard regression model was used to evaluate risk factors for PFS. Ninety-two patients were recruited. 53 (57.6 %), 27 (29.3 %), and 12 (13 %) patients received CG, CF, and FOLFIRINOX regimen as first-line chemotherapy, respectively. Median PFS and DCR of CG group were 22 weeks and 56.6 %, and these were 12 weeks and 44.4 % for CF group, and 9 weeks and 41.7 % for FOLFIRINOX group. Median OS of CG, CF, and FOLFIRINOX groups was 28, 21,and 23.5 weeks, respectively (p = 0.497). Second-line PFS of fluoropyrimidine -based chemotherapy group and gemcitabine -based chemotherapy group was 12 vs. 14 weeks (p = 0.988). Second-line PFS of FOLFIRINOX was 20 weeks, whereas it was 14 weeks for other fuoropyrimidine -based chemotherapies (p = 0.190). This was the first study evaluating the FOLFIRINOX regimen in BTC. Cisplatin-gemcitabine therapy still provides better survival in BCT. However, FOLFIRINOX can be an option in the second-line treatment of BTC patients who are eligible for chemotherapy. |
[
"O",
"O",
"B-T022",
"O",
"B-T091",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"B-T022",
"O",
"B-T091",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1123023",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0013851",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Mechanically",
"Reinforced",
"Skin",
"-",
"Electronics",
"with",
"Networked",
"Nanocomposite",
"Elastomer",
"Mechanically",
"reinforced",
"skin",
"-",
"electronics",
"are",
"presented",
"by",
"exploiting",
"networked",
"nanocomposite",
"elastomers",
"where",
"high",
"q... | [
[
0,
12
],
[
13,
23
],
[
24,
28
],
[
29,
30
],
[
31,
42
],
[
43,
47
],
[
48,
57
],
[
58,
71
],
[
72,
81
],
[
82,
94
],
[
95,
105
],
[
106,
110
],
[
111,
112
],
... | Mechanically Reinforced Skin - Electronics with Networked Nanocomposite Elastomer Mechanically reinforced skin - electronics are presented by exploiting networked nanocomposite elastomers where high quality metal nanowires serve as conducting paths. Theoretical and experimental studies show that the established skin - electronics exhibit superior mechanical enhancements against crack and delamination phenomena. Device applications include a class of biomedical devices that offers the ability of thermotherapeutic stimulation and electrophysiological monitoring, all via the skin. |
[
"B-T058",
"O",
"O",
"B-T103",
"O",
"B-T103",
"O",
"B-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"O",
"B-T007",
"B-T091",
"O",
"O",
"O",
... | [
{
"db_id": "C0087111",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0020282",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0054714",
"db_name": "UMLS"
},
{
... | [
"Therapeutic",
"Delivery",
"of",
"H2S",
"via",
"COS",
":",
"Small",
"Molecule",
"and",
"Polymeric",
"Donors",
"with",
"Benign",
"Byproducts",
"Carbonyl",
"sulfide",
"(",
"COS",
")",
"is",
"a",
"gas",
"that",
"may",
"play",
"important",
"roles",
"in",
"mammal... | [
[
0,
11
],
[
12,
20
],
[
21,
23
],
[
24,
27
],
[
28,
31
],
[
32,
35
],
[
35,
36
],
[
37,
42
],
[
43,
51
],
[
52,
55
],
[
56,
65
],
[
66,
72
],
[
73,
77
],
[
... | Therapeutic Delivery of H2S via COS: Small Molecule and Polymeric Donors with Benign Byproducts Carbonyl sulfide (COS) is a gas that may play important roles in mammalian and bacterial biology, but its study is limited by a lack of suitable donor molecules. We report here the use of N-thiocarboxyanhydrides (NTAs) as COS donors that release the gas in a sustained manner under biologically relevant conditions with innocuous peptide byproducts. Carbonic anhydrase converts COS into H2S, allowing NTAs to serve as either COS or H2S donors, depending on the availability of the enzyme. Analysis of the pseudo-first-order H2S release rate under biologically relevant conditions revealed a release half-life of 75 min for the small molecule NTA under investigation. A polynorbornene bearing pendant NTAs made by ring-opening metathesis polymerization was also synthesized to generate a polymeric COS / H2S donor. A half-life of 280 min was measured for the polymeric donor. Endothelial cell proliferation studies revealed an enhanced rate of proliferation for cells treated with the NTA over untreated controls. |
[
"B-T103",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"B-T022",
"I-T022",
"I-T022",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"... | [
{
"db_id": "C0664336",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C002... | [
"Survivin",
"is",
"a",
"guardian",
"of",
"the",
"intestinal",
"stem",
"cell",
"niche",
"and",
"its",
"expression",
"is",
"regulated",
"by",
"TGF",
"-",
"β",
"As",
"an",
"inhibitor",
"of",
"apoptosis",
"(",
"IAP",
")",
"family",
"member",
",",
"Survivin",
... | [
[
0,
8
],
[
9,
11
],
[
12,
13
],
[
14,
22
],
[
23,
25
],
[
26,
29
],
[
30,
40
],
[
41,
45
],
[
46,
50
],
[
51,
56
],
[
57,
60
],
[
61,
64
],
[
65,
75
],
[
7... | Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF-β As an inhibitor of apoptosis (IAP) family member, Survivin is known for its role during regulation of apoptosis. More recently its function as a cell cycle regulator has become evident. Survivin was shown to play a pivotal role during embryonic development and is highly expressed in regenerative tissue as well as in many cancer types. We examined the function of Survivin during mouse intestinal organogenesis and in gut pathophysiology. We found high expression of Survivin in experimentally induced colon cancer in mice but also in colon tumors of humans. Moreover, Survivin was regulated by TGF-β and was found to be highly expressed during mucosal healing following intestinal inflammation. We identified that expression of Survivin is essential early on in life, as specific deletion of Survivin in Villin expressing cells led to embryonic death around day 12 post coitum. Together with our recent study on the role of Survivin in the gut of adult mice our data demonstrate that Survivin is an essential guardian of embryonic gut development and adult gut homeostasis protecting the epithelium from cell death promoting the proliferation of intestinal stem and progenitor cells. |
[
"B-T082",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"B-T082",
"O",
"B-T058",
"O",
"O",
"O",
... | [
{
"db_id": "C0205095",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0543467",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Posterior",
"corrective",
"surgery",
"with",
"a",
"multilevel",
"transforaminal",
"lumbar",
"interbody",
"fusion",
"and",
"a",
"rod",
"rotation",
"maneuver",
"for",
"patients",
"with",
"degenerative",
"lumbar",
"kyphoscoliosis",
"The",
"purpose",
"of",
"this",
"stu... | [
[
0,
9
],
[
10,
20
],
[
21,
28
],
[
29,
33
],
[
34,
35
],
[
36,
46
],
[
47,
61
],
[
62,
68
],
[
69,
78
],
[
79,
85
],
[
86,
89
],
[
90,
91
],
[
92,
95
],
[
... | Posterior corrective surgery with a multilevel transforaminal lumbar interbody fusion and a rod rotation maneuver for patients with degenerative lumbar kyphoscoliosis The purpose of this study was to assess the clinical results of posterior corrective surgery using a multilevel transforaminal lumbar interbody fusion (TLIF) with a rod rotation (RR) and to evaluate the segmental corrective effect of a TLIF using CT imaging. The medical records of 15 consecutive patients with degenerative lumbar kyphoscoliosis (DLKS) who had undergone posterior spinal corrective surgery using a multileve l TLIF with an RR technique and who had a minimum follow-up of 2 years were retrospectively reviewed. Radiographic parameters were evaluated using plain radiographs, and segmental correction was evaluated using CT imaging. Clinical outcomes were evaluated with the Scoliosis Research Society Patient Questionnaire-22 (SRS-22) and the SF-36. The mean follow-up period was 46.7 months, and the mean age at the time of surgery was 60.7 years. The mean total SRS-22 score was 2.9 before surgery and significantly improved to 4.0 at the latest follow-up. The physical functioning, role functioning (physical), and social functioning subcategories of the SF-36 were generally improved at the latest follow-up, although the changes in these scores were not statistically significant. The bodily pain, vitality, and mental health subcategories were significantly improved at the latest follow-up (p < 0.05). Three complications occurred in 3 patients (20%). The Cobb angle of the lumbar curve was reduced to 20.3° after surgery. The overall correction rate was 66.4%. The pelvic incidence - lumbar lordosis (preoperative / postoperative = 31.5°/4.3°), pelvic tilt (29.2°/18.9°), and sagittal vertical axis (78.3/27.6 mm) were improved after surgery and remained so throughout the follow-up. Computed tomography image analysis suggested that a 1-level TLIF can result in 10.9° of scoliosis correction and 6.8° of lordosis. Posterior corrective surgery using a multilevel TLIF with an RR on patients with DLKS can provide effective correction in the coronal plane but allows only limited sagittal correction. |
[
"O",
"O",
"O",
"O",
"B-T098",
"O",
"O",
"B-T062",
"O",
"B-T058",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"B-T170",
"I-T170",
"I-T170",
"O",
"B-T170",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0238711",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,... | [
"A",
"scoping",
"review",
"of",
"Australian",
"allied",
"health",
"research",
"in",
"ehealth",
"Uptake",
"of",
"e",
"-",
"health",
",",
"the",
"use",
"of",
"information",
"communication",
"technologies",
"(",
"ICT",
")",
"for",
"health",
"service",
"delivery",... | [
[
0,
1
],
[
2,
9
],
[
10,
16
],
[
17,
19
],
[
20,
30
],
[
31,
37
],
[
38,
44
],
[
45,
53
],
[
54,
56
],
[
57,
64
],
[
65,
71
],
[
72,
74
],
[
75,
76
],
[
76... | A scoping review of Australian allied health research in ehealth Uptake of e-health, the use of information communication technologies (ICT) for health service delivery, in allied health appears to be lagging behind other health care areas, despite offering the potential to address problems with service access by rural and remote Australians. The aim of the study was to conduct a scoping review of studies into the application of or attitudes towards ehealth amongst allied health professionals conducted in Australia. Studies meeting inclusion criteria published from January 2004 to June 2015 were reviewed. Professions included were audiology, dietetics, exercise physiology, occupational therapy, physiotherapy, podiatry, social work, and speech pathology. Terms for these professions and forms of ehealth were combined in databases of CINAHL (EBSCO), Cochrane Library, PsycINFO (1806 - Ovid), MEDLINE (Ovid) and AMED (Ovid). Forty-four studies meeting inclusion criteria were summarised. They were either trials of aspects of ehealth service delivery, or clinician and/or client use of and attitudes towards ehealth. Trials of ehealth were largely from two research groups located at the Universities of Sydney and Queensland; most involved speech pathology and physiotherapy. Assessments through ehealth and intervention outcomes through ehealth were comparable with face-to-face delivery. Clinicians used ICT mostly for managing their work and for professional development, but were reticent about its use in service delivery, which contrasted with the more positive attitudes and experiences of clients. The potential of ehealth to address allied health needs of Australians living in rural and remote Australia appears unrealised. Clinicians may need to embrace ehealth as a means to radicalise practice, rather than replicate existing practices through a different mode of delivery. |
[
"O",
"O",
"B-T037",
"I-T037",
"I-T037",
"O",
"O",
"O",
"O",
"B-T082",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T037",
"I-T037",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C3263722",
"db_name": "UMLS"
},
{
"db_id": "C3263722",
"db_name": "UMLS"
},
{
"db_id": "C3263722",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
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{
... | [
"Association",
"of",
"Traumatic",
"and",
"Atraumatic",
"Posterior",
"Shoulder",
"Instability",
"With",
"Glenoid",
"Retroversion",
"and",
"Outcomes",
"After",
"Arthroscopic",
"Capsulolabral",
"Repair",
"To",
"compare",
"glenoid",
"retroversion",
"and",
"functional",
"out... | [
[
0,
11
],
[
12,
14
],
[
15,
24
],
[
25,
28
],
[
29,
39
],
[
40,
49
],
[
50,
58
],
[
59,
70
],
[
71,
75
],
[
76,
83
],
[
84,
96
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[
97,
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[
101,
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[
... | Association of Traumatic and Atraumatic Posterior Shoulder Instability With Glenoid Retroversion and Outcomes After Arthroscopic Capsulolabral Repair To compare glenoid retroversion and functional outcomes between patients with traumatic onset of posterior shoulder instability (PSI) and patients with atraumatic onset of PSI. Patients with PSI who underwent arthroscopic posterior capsulolabral anchor repair, were active in sports, and had undergone surgery a minimum of 2 years earlier were included. Traumatic onset was defined as PSI that occurred after a trauma with the shoulder in adduction, flexion, and internal rotation in patients with no history of instability. Subjective evaluations were obtained with the American Shoulder and Elbow Surgeons (ASES); Quick Disabilities of the Arm, Shoulder and Hand; Single Assessment Numeric Evaluation (SANE); and Short Form 12 Physical Component Summary scores preoperatively and after a minimum 2-year follow-up postoperatively. Additional questions assessed return to sport and shoulder stability. Glenoid version was measured with a 2-dimensional glenoid vault method on magnetic resonance imaging. A total of 41 shoulders in 38 patients were eligible for inclusion (3 female and 35 male patients; mean age, 27.6 years; age range, 13 to 66 years). Three patients refused participation, and 2 patients required subsequent surgery for failure. Postoperative outcomes were available for 32 of the remaining 36 shoulders (89%) with a mean follow-up of 4.1 years (range, 2.0 to 7.8 years; 20 atraumatic and 12 traumatic). The ASES score improved significantly in both groups (P < .03), whereas the SANE; Quick Disabilities of the Arm, Shoulder and Hand; and Short Form 12 Physical Component Summary scores only significantly improved for patients with traumatic PSI (P < .02). Baseline score-adjusted comparison between groups showed that the postoperative median ASES scores (atraumatic, 95.8; traumatic, 99.9) and SANE scores (atraumatic, 86.5; traumatic, 98.0) were significantly more improved in patients with traumatic PSI (P = .01 and P = .012, respectively). Atraumatic PSI was associated with significantly higher glenoid retroversion (-21.8° ± 4.2° vs -17.7° ± 5.5°, P = .032). There was no significant difference regarding return to sport (P = .375) or postoperative re-dislocations (P = .99) between the groups. Atraumatic onset of PSI was associated with higher degrees of glenoid retroversion and less favorable functional outcomes of arthroscopic posterior capsulolabral anchor repair than traumatic PSI. Level III, retrospective case-control study. |
[
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"B-T058",
"I-T058",
"I-T058",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T038",
"O",
"B-T038",
"B-T038",
"O",
"O",
"O",
"B-T... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0430678",
"db_name": "UMLS"
},
{
"db_id": "C043... | [
"Optimization",
"of",
"techniques",
"for",
"multiple",
"platform",
"testing",
"in",
"small",
",",
"precious",
"samples",
"such",
"as",
"human",
"chorionic",
"villus",
"sampling",
"Multiple",
"testing",
"to",
"understand",
"global",
"changes",
"in",
"gene",
"expres... | [
[
0,
12
],
[
13,
15
],
[
16,
26
],
[
27,
30
],
[
31,
39
],
[
40,
48
],
[
49,
56
],
[
57,
59
],
[
60,
65
],
[
65,
66
],
[
67,
75
],
[
76,
83
],
[
84,
88
],
[
... | Optimization of techniques for multiple platform testing in small, precious samples such as human chorionic villus sampling Multiple testing to understand global changes in gene expression based on genetic and epigenetic modifications is evolving. Chorionic villi, obtained for prenatal testing, is limited, but can be used to understand ongoing human pregnancies. However, optimal storage, processing and utilization of CVS for multiple platform testing have not been established. Leftover CVS samples were flash-frozen or preserved in RNAlater. Modifications to standard isolation kits were performed to isolate quality DNA and RNA from samples as small as 2-5 mg. RNAlater samples had significantly higher RNA yields and quality and were successfully used in microarray and RNA-sequencing (RNA-seq). RNA-seq libraries generated using 200 versus 800-ng RNA showed similar biological coefficients of variation. RNAlater samples had lower DNA yields and quality, which improved by heating the elution buffer to 70 °C. Purification of DNA was not necessary for bisulfite-conversion and genome-wide methylation profiling. CVS cells were propagated and continue to express genes found in freshly isolated chorionic villi. CVS samples preserved in RNAlater are superior. Our optimized techniques provide specimens for genetic, epigenetic and gene expression studies from a single small sample which can be used to develop diagnostics and treatments using a systems biology approach in the prenatal period. © 2016 John Wiley & Sons, Ltd. |
[
"O",
"O",
"O",
"B-T038",
"B-T038",
"O",
"B-T038",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T082",
"I-T082",
"O",
"B-T062",
"I-T062",
"I-T062",
"I-T062",
"I-T062",
"I-T062",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0013146",
"db_name": "UMLS"
},
{
"db_id": "C0006868",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Relationship",
"Between",
"Frequent",
"Recreational",
"Cannabis",
"(",
"Marijuana",
"and",
"Hashish",
")",
"Use",
"and",
"Periodontitis",
"in",
"Adults",
"in",
"the",
"United",
"States",
":",
"National",
"Health",
"and",
"Nutrition",
"Examination",
"Survey",
"201... | [
[
0,
12
],
[
13,
20
],
[
21,
29
],
[
30,
42
],
[
43,
51
],
[
52,
53
],
[
53,
62
],
[
63,
66
],
[
67,
74
],
[
74,
75
],
[
76,
79
],
[
80,
83
],
[
84,
97
],
[
... | Relationship Between Frequent Recreational Cannabis (Marijuana and Hashish) Use and Periodontitis in Adults in the United States: National Health and Nutrition Examination Survey 2011 to 2012 Recreational use of cannabis, following its legalization in some countries, poses emergent oral and periodontal health concerns. The objective of this study is to examine the relationship between frequent recreational cannabis (FRC) (marijuana and hashish) use and periodontitis prevalence among adults in the United States. Data from the National Health and Nutrition Examination Survey (NHANES) 2011 to 2012 were analyzed. Primary outcome (periodontitis) was defined using the Centers for Disease Control and Prevention / American Academy of Periodontology classification as well as continuous measurements of probing depth (PD) and clinical attachment loss (AL). Exposure of interest was self-reported cannabis use, defined as " FRC use " versus " non-FRC use ." Bivariate and multivariable regression models were performed using the entire analytical sample (model 1) as well as those who had never used tobacco (never-users) (model 2). Of 1,938 participants with available cannabis use data and essential covariates, 26.8% were FRC users. Mean number of sites per participant with PD ≥4, ≥6, and ≥8 mm and AL ≥3, ≥5, and ≥8 mm was significantly higher among FRC users than among non-FRC users (mean difference in number of PD sites: 6.9, 5.6, and 5.6; P <0.05; mean difference in number of AL sites: 12.7, 7.6, and 5.6; P <0.05). Average AL was higher among FRC users than among non-FRC users (1.8 versus 1.6 mm; P = 0.004). Bivariate analysis revealed positive (harmful) association between FRC use and severe periodontitis in the entire sample (odds ratio [OR]: 1.7, 95% confidence interval [CI]: 1.3 to 2.4; P = 0.002) as well as in never-smokers (OR: 2.0, 95% CI: 1.2 to 3.5; P = 0.01). This association was retained in multivariable models adjusted for demographics (age, sex, race / ethnicity, and income level), alcohol and tobacco use, diabetes mellitus, and past periodontal treatment (model 1: adjusted OR [aOR]: 1.4, 95% CI: 1.1 to 1.9; P = 0.07; model 2: aOR: 1.9, 95% CI: 1.1 to 3.2; P = 0.03). FRC use is associated with deeper P D s, more clinical AL, and higher odds of having severe periodontitis. |
[
"B-T058",
"O",
"O",
"B-T103",
"O",
"B-T204",
"I-T204",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"B-T168",
"B-T058",
"I-T058",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"B-T058",
"O",
"O",
"B-T103",
"O",
"B-T103",
... | [
{
"db_id": "C1148554",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0031253",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1088997",
"db_name": "UMLS"
},
{
... | [
"Determination",
"of",
"eight",
"pesticides",
"in",
"Lycium",
"barbarum",
"by",
"LC",
"-",
"MS",
"/",
"MS",
"and",
"dietary",
"risk",
"assessment",
"A",
"LC",
"-",
"MS",
"/",
"MS",
"method",
"for",
"determination",
"of",
"eight",
"pesticides",
"(",
"triadi... | [
[
0,
13
],
[
14,
16
],
[
17,
22
],
[
23,
33
],
[
34,
36
],
[
37,
43
],
[
44,
52
],
[
53,
55
],
[
56,
58
],
[
58,
59
],
[
59,
61
],
[
61,
62
],
[
62,
64
],
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... | Determination of eight pesticides in Lycium barbarum by LC-MS/MS and dietary risk assessment A LC-MS/MS method for determination of eight pesticides (triadimefon, sulfoxaflor, flusilazole, tebuconazole, difenoconazole, amitraz, azoxystrobin, and thiophanate-methyl) in Lycium barbarum was established. The samples were extracted with acetonitrile, and then cleaned up by primary secondary amine. The extracts were diluted with 0.1% formic acid in water. The results showed that at the fortified levels of 0.01-10mg/kg, the average recoveries of these pesticides ranged from 82.1% to 96.2% with the relative standard deviations lower than 7%. The half-lives of eight pesticides were 1.3-5.0days in Lycium barbarum fruits. The pre-harvest interval of all pesticides mentioned above were investigated. Tebuconazole (14days), sulfoxaflor (14days) and flusilazole (28days) have longer pre-harvest interval than the others which have 7days. The dietary risks, assessed as hazard quotients, were far below 100%. The results showed that the eight pesticides applied to Lycium barbarum were comparably safe for the consumer. |
[
"O",
"B-T103",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T170",
"I-T170",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"B-T168",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T168",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0014442",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0022947",
"db_name": "UMLS"
},
{
"db_id": "C0022947",
"db_name": "UMLS"
},
{
... | [
"Selective",
"enzymatic",
"hydrolysis",
"of",
"chlorogenic",
"acid",
"lactones",
"in",
"a",
"model",
"system",
"and",
"in",
"a",
"coffee",
"extract",
".",
"Application",
"to",
"reduction",
"of",
"coffee",
"bitterness",
"Chlorogenic",
"acid",
"lactones",
"have",
... | [
[
0,
9
],
[
10,
19
],
[
20,
30
],
[
31,
33
],
[
34,
45
],
[
46,
50
],
[
51,
59
],
[
60,
62
],
[
63,
64
],
[
65,
70
],
[
71,
77
],
[
78,
81
],
[
82,
84
],
[
... | Selective enzymatic hydrolysis of chlorogenic acid lactones in a model system and in a coffee extract. Application to reduction of coffee bitterness Chlorogenic acid lactones have been identified as key contributors to coffee bitterness. These compounds are formed during roasting by dehydration and cyclization of their precursors, the chlorogenic acids (CGAs). In the present study, we investigated an approach to decompose these lactones in a selective way without affecting the positive coffee attributes developed during roasting. A model system composed of (3-caffeoylquinic acid lactone (3-CQAL), 4- caffeoyl quinic acid lactone (4-CQAL), and 4-feruloylquinic acid lactone (4-FQAL)) was used for the screening of enzymes before treatment of the coffee extracts. Hog liver esterase (HLE) hydrolyzed chlorogenic acid lactones (CQALs, FQALs) selectively, while chlorogenate esterase hydrolyzed all chlorogenic acids (CQAs, FQAs) and their corresponding lactones (CQALs, FQALs) in a non-selective way. Enzymatically treated coffee samples were evaluated for their bitterness by a trained sensory panel and were found significantly less bitter than the untreated samples. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"B-T017",
"B-T058",
"I... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"Association",
"between",
"ventricular",
"filling",
"patterns",
"and",
"the",
"extent",
"of",
"late",
"enhancement",
"on",
"magnetic",
"resonance",
"imaging",
"in",
"patients",
"with",
"hypertrophic",
"cardiomyopathy",
"To",
"explore",
"the",
"relationship",
"between"... | [
[
0,
11
],
[
12,
19
],
[
20,
31
],
[
32,
39
],
[
40,
48
],
[
49,
52
],
[
53,
56
],
[
57,
63
],
[
64,
66
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[
67,
71
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[
72,
83
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[
84,
86
],
[
87,
95
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... | Association between ventricular filling patterns and the extent of late enhancement on magnetic resonance imaging in patients with hypertrophic cardiomyopathy To explore the relationship between ventricular filling curves and the extent of late enhancement on cardiac magnetic resonance imaging (MRI) in patients with hypertrophic cardiomyopathy. We retrospectively included consecutive patients with suspected and/or confirmed hypertrophic cardiomyopathy and a control group of patients matched for age and sex who underwent cardiac MRI with evaluation of late enhancement. Among other determinations, we evaluated the following parameters on cine sequences: peak filling rate, time to the first peak filling rate, and filling rate normalized to the filling volume. Late enhancement was observed in 29 (73%) of the 40 patients with hypertrophic cardiomyopathy. The normalized peak filling rate was significantly lower in patients with late enhancement (4.9 ± 1.6 in those with hypertrophic cardiomyopathy positive for late enhancement vs. 5.8 ± 2.2 in those with hypertrophic cardiomyopathy negative for late enhancement vs. 6.3 ± 1.5 in controls, p = 0.008) and the time to peak filling was longer in patients with late enhancement (540.6 ± 89.7 ms vs. 505.5 ± 99.3 ms in those with hypertrophic cardiomyopathy negative for late enhancement vs. 486.9 ± 86.3 ms in controls, p = 0.02). When the population was stratified into three groups in function of the normalized peak filling rate, significant differences were observed among groups for age (p = 0.002), mean wall thickness (p = 0.036), and myocardial mass (p = 0.046) and atrial dimensions, whereas no significant differences with respect to late enhancement were seen. In patients with hypertrophic cardiomyopathy, we found a significant association between ventricular filling patterns and age, wall thicknesses, and atrial dimensions, but not with the extent of late enhancement. |
[
"B-T017",
"I-T017",
"O",
"O",
"O",
"O",
"B-T017",
"B-T038",
"O",
"B-T033",
"O",
"B-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"B-T062",
"I-T062",
"O",
"B-T017"... | [
{
"db_id": "C0038250",
"db_name": "UMLS"
},
{
"db_id": "C0038250",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
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{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id... | [
"Stem",
"cells",
"and",
"their",
"role",
"in",
"pituitary",
"tumorigenesis",
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"stem",
"cells",
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"PSCs",
")",
"has",
"been",
"described",
"in",
"murine",
"systems",
"by",
"comprehensive",
"cellular",
"profiling",
... | [
[
0,
4
],
[
5,
10
],
[
11,
14
],
[
15,
20
],
[
21,
25
],
[
26,
28
],
[
29,
38
],
[
39,
52
],
[
53,
56
],
[
57,
65
],
[
66,
68
],
[
69,
74
],
[
75,
84
],
[
8... | Stem cells and their role in pituitary tumorigenesis The presence of adult pituitary stem cells (PSCs) has been described in murine systems by comprehensive cellular profiling and genetic lineage tracing experiments. PSCs are thought to maintain multipotent capacity throughout life and give rise to all hormone -producing cell lineages, playing a role in pituitary gland homeostasis. Additionally, PSCs have been proposed to play a role in pituitary tumorigenesis, in both adenomas and adamantinomatous craniopharyngiomas. In this manuscript, we discuss the different approaches used to demonstrate the presence of PSCs in the murine adult pituitary, from marker analyses to genetic tracing. In addition, we review the published literature suggesting the existence of tumor stem cells in mouse and human pituitary tumors. Finally, we discuss the potential role of PSCs in pituitary tumorigenesis in the context of current models of carcinogenesis and present evidence showing that in contrast to pituitary adenoma, which follows a classical cancer stem cell paradigm, a novel mechanism has been revealed for paracrine, non-cell autonomous tumor initiation in adamantinomatous craniopharyngioma, a benign but clinically aggressive pediatric tumor. |
[
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T033",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"B-T058",
"O",
"O",
"B-T092",
"I-T092",
"I-T092",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"B-T0... | [
{
"db_id": "C0003993",
"db_name": "UMLS"
},
{
"db_id": "C0003993",
"db_name": "UMLS"
},
{
"db_id": "C0003993",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1704258",
"db_name": "UMLS"
}... | [
"L",
"-",
"asparaginase",
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"induced",
"abnormality",
"in",
"plasma",
"glucose",
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"lymphoblastic",
"leukemia",
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"tertiary",
"care",
"hospital",
"of",
"Odisha",
"The",
"objective",
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... | [
[
0,
1
],
[
1,
2
],
[
2,
14
],
[
15,
16
],
[
17,
24
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[
25,
36
],
[
37,
39
],
[
40,
46
],
[
47,
54
],
[
55,
60
],
[
61,
63
],
[
64,
72
],
[
73,
75
],
[
76,... | L-asparaginase - induced abnormality in plasma glucose level in patients of acute lymphoblastic leukemia admitted to a tertiary care hospital of Odisha The objective of this study was to evaluate any abnormal change in plasma glucose levels in patients treated with L-asparaginase (L-Asp)-based chemotherapy regimen in patients of acute lymphoblastic leukemia (ALL). This retrospective, hospital-based study was conducted in patients of ALL, admitted to the Clinical Haematology Department of a tertiary care hospital of Odisha from August 2014 to July 2015. Indoor records of 146 patients on multi-centered protocol-841 were evaluated for any alteration in plasma glucose level, time of onset of hypo / hyperglycemia, and persistence of plasma glucose alteration. Twenty-one percent of patients showed abnormal plasma glucose level. Most of these patients developed hypoglycemia and were of lower age group. Most of these patients developed hypoglycemia and were of lower age group, whereas a majority of higher age group patients developed hyperglycemia. In majority of the cases, abnormal glucose developed after three doses of L-Asp. Hypoglycemia subsided whereas hyperglycemia persisted till the end of our observation period. L-Asp produces more incidences of hypoglycemia than hyperglycemia in a good number of ALL patients towards which clinicians should be more vigilant. However, hyperglycemia persists for a longer duration than hypoglycemia. |
[
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"B-T062",
"O",
"O",... | [
{
"db_id": "C1457880",
"db_name": "UMLS"
},
{
"db_id": "C1457880",
"db_name": "UMLS"
},
{
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},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id... | [
"Sonic",
"hedgehog",
"in",
"oral",
"squamous",
"cell",
"carcinoma",
":",
"An",
"immunohistochemical",
"study",
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"hedgehog",
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"Hh",
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"component",
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"and",
... | [
[
0,
5
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[
6,
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15,
17
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[
18,
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[
23,
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[
32,
36
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[
37,
46
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[
46,
47
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[
48,
50
],
[
51,
70
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[
71,
76
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[
77,
83
],
[
84,
91
],
[
9... | Sonic hedgehog in oral squamous cell carcinoma: An immunohistochemical study Recent studies have revealed the involvement of hedgehog (Hh) signaling component in proliferation and invasive behavior of many carcinomas. This study aims to identify the expression of sonic Hh (SHH) protein of SHH pathway in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC) using SHH (H-160) (Santa Cruz, sc-9042) which could have therapeutic implication in future. A total of 250 cases comprising 50 normal oral mucosa, 50 cases of oral epithelial dysplasia, 50 well, 50 moderate and 50 poorly differentiated OSCCs were included in the study. Immunohistochemical evaluation of SHH protein expression was conducted using monoclonal antibody. Interpretation of the expression was done by immunoreactive score of Remmele and Stegner (IRS) scoring method. Chi-Square test was used to analyze the results. The study showed that SHH signaling molecules are highly expressed in OSCC, and their expression was mainly in the cytoplasm of epithelial cells. The SHH signaling component is associated with the pathological parameter in OSCC and oral epithelial dysplasia. |
[
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"B-T097",
"I-T097",
"I-T097",
"O",
"O",
"B-T037",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T097",
"I-T097",
"I-T097",
"O",
"B-T038"... | [
{
"db_id": "C0496674",
"db_name": "UMLS"
},
{
"db_id": "C0496674",
"db_name": "UMLS"
},
{
"db_id": "C0496674",
"db_name": "UMLS"
},
{
"db_id": "C0496674",
"db_name": "UMLS"
},
{
"db_id": "C0496674",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": ... | [
"Trauma",
"-",
"Informed",
"Medical",
"Care",
":",
"Patient",
"Response",
"to",
"a",
"Primary",
"Care",
"Provider",
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"exposure",
"predicts",
"mental",
"disorders",
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"health",
"outcomes",
";",
"yet",
"there",
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"lit... | [
[
0,
6
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6,
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24,
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28,
29
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[
30,
37
],
[
38,
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[
47,
49
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[
50,
51
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[
52,
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60,
64
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[
65,
73
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[
74,... | Trauma-Informed Medical Care: Patient Response to a Primary Care Provider Communication Training Trauma exposure predicts mental disorders and health outcomes; yet there is little training of primary care providers about trauma's effects, and how to better interact with trauma survivors. This study adapted a theory-based approach to working with trauma survivors, Risking Connection, into a 6-hour CME course, Trauma-Informed Medical Care (TI-Med), to evaluate its feasibility and preliminary efficacy. We randomized four primary care sites to training or wait-list conditions; PCPs at wait-list sites were trained after reassessment. Primary care providers (PCPs) were Family Medicine residents (n = 17; 2 sites) or community physicians (n = 13; 2 sites). Outcomes reported here comprised a survey of 400 actual patients seen by the PCPs in the study. Patients, mostly minority, completed surveys before or after their provider received training. Patients rated PCPs significantly higher after training on a scale encompassing partnership issues. Breakdowns showed lower partnership scores for those with trauma or posttraumatic stress symptoms. Future studies will need to include more specific trauma-related outcomes. Nevertheless, this training is a promising initial approach to teaching trauma-informed communication skills to PCPs. |
[
"O",
"B-T017",
"I-T017",
"O",
"B-T082",
"B-T082",
"O",
"O",
"B-T017",
"O",
"B-T017",
"I-T017",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0149955",
"db_name": "UMLS"
},
{
"db_id": "C0149955",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0574895",
"db_name": "UMLS"
},
{
"db_id": "C1882151",
"db_name": "UMLS"
}... | [
"Incomplete",
"Annular",
"Pancreas",
"with",
"Ectopic",
"Opening",
"of",
"the",
"Pancreatic",
"and",
"Bile",
"Ducts",
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"a",
"56",
"-",
"year",
"... | [
[
0,
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[
11,
18
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[
19,
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],
[
28,
32
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[
33,
40
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[
41,
48
],
[
49,
51
],
[
52,
55
],
[
56,
66
],
[
67,
70
],
[
71,
75
],
[
76,
81
],
[
82,
86
],
[
... | Incomplete Annular Pancreas with Ectopic Opening of the Pancreatic and Bile Ducts into the Pyloric Ring: First Report of a Rare Anomaly The patient was a 56-year-old woman who had experienced epigastralgia and dorsal pain several times over the last 20 years. She was admitted for a diagnosis of acute cholecystitis, and severe intra - and extrahepatic bile duct dilatation with inner air density was noted. No papilla of Vater was present in the descending duodenum, and 2 small holes were present in the pyloric ring. Bile excretion from one of the small holes was observed under forward-viewing endoscope. It was considered that the pancreatic and bile ducts separately opened into the pyloric ring. Based on these findings, malformation of the pancreaticobiliary duct was diagnosed. She did not wish treatment, but the obstruction associated with duodenal stenosis was noted after 2 years. Pancreatoduodenectomy was performed as curative treatment for duodenal stenosis and retrograde biliary infection through the bile duct opening in the pyloric ring. The ventral pancreas encompassed almost the entire circumference of the pyloric ring, suggesting a subtype of annular pancreas. Generally, lesions are present in the descending part of the duodenum in an annular pancreas, and the pancreatic and bile ducts join in the papillary region. However, in this patient, (1) the pancreas encompassed the pyloric ring, (2) the pancreatic and bile ducts opened separately, and (3) the openings of the pancreatic and bile duct s were present in the pyloric ring. The pancreas and biliary tract develop through a complex process, which may cause various types of malformation of the pancreaticobiliary system, but no similar case report was found on a literature search. This case was very rare and could not be classified in any type of congenital anomaly of the pancreas. We would classify it as a subtype of annular pancreas with separate ectopic opening of the pancreatic and bile ducts into the pyloric ring. |
[
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T007",
"I-T007",
"O",
"O",
"O",
"O",
"B-T005",
"I-T005",
"I-T005",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T007",
"I-T007",
"O",
"O",
"O",
"O",
"B-T005",
"I-T005",
"I-T005",
"O",
"B-T005",
"I-T005... | [
{
"db_id": "C0853336",
"db_name": "UMLS"
},
{
"db_id": "C0853336",
"db_name": "UMLS"
},
{
"db_id": "C0853336",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0036766",
"db_name": "UMLS"
}... | [
"Corneal",
"Ring",
"Infiltrates",
"Caused",
"by",
"Serratia",
"marcescens",
"in",
"a",
"Patient",
"with",
"Human",
"Immunodeficiency",
"Virus",
"To",
"describe",
"corneal",
"ring",
"infiltrates",
"caused",
"by",
"Serratia",
"marcescens",
"in",
"a",
"patient",
"wit... | [
[
0,
7
],
[
8,
12
],
[
13,
24
],
[
25,
31
],
[
32,
34
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[
35,
43
],
[
44,
54
],
[
55,
57
],
[
58,
59
],
[
60,
67
],
[
68,
72
],
[
73,
78
],
[
79,
95
],
[
9... | Corneal Ring Infiltrates Caused by Serratia marcescens in a Patient with Human Immunodeficiency Virus To describe corneal ring infiltrates caused by Serratia marcescens in a patient with human immunodeficiency virus (HIV-1) who wore contact lenses. A case study of a patient with keratitis due to an infection caused by S. marcescens and exhibiting corneal ring infiltrates was reviewed for history, clinical manifestation, microscopic study, and management. A 29-year-old man who had a history of contact lens wear and HIV-1 infection was admitted to hospital because of blurred vision, redness, and corneal infiltrates in the shape of a ring in the left eye. The visual acuity (VA) in both eyes was hand movement (uncorrected). Corneal scrapings were performed. The culture results of the corneal specimens revealed S. marcescens. The culture results of the contact lens disclosed the same organism. The corneal ulcer responded well to treatment with topical gentamycin sulfate 14 mg/ml. The final VA remained hand movemen t. S. marcescens can cause ring infiltrates in a HIV-1 patient who wears contact lenses. The treatment result for S. marcescens keratitis in a HIV-1 patient who wore contact lenses was favorable after intensive use of fortified topical antibiotics. |
[
"O",
"B-T037",
"B-T033",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T098",
"I-T098",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T062",
"I-T062",
"I-T062",
"B-T037",
"I-T037",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"B-T098",
"O",
"O",
"O",
"B-T098",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C3714660",
"db_name": "UMLS"
},
{
"db_id": "C1457887",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0030971",
"db_name": "UMLS"
},
{
"db_id": "C0030971",
"db_name": "UMLS"
}... | [
"Reduced",
"Trauma",
"Symptoms",
"and",
"Perceived",
"Stress",
"in",
"Male",
"Prison",
"Inmates",
"through",
"the",
"Transcendental",
"Meditation",
"Program",
":",
"A",
"Randomized",
"Controlled",
"Trial",
"Trauma",
"events",
"are",
"four",
"times",
"more",
"preva... | [
[
0,
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],
[
8,
14
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[
15,
23
],
[
24,
27
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[
28,
37
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[
38,
44
],
[
45,
47
],
[
48,
52
],
[
53,
59
],
[
60,
67
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[
68,
75
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[
76,
79
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[
80,
94
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[
9... | Reduced Trauma Symptoms and Perceived Stress in Male Prison Inmates through the Transcendental Meditation Program: A Randomized Controlled Trial Trauma events are four times more prevalent in inmates than in the general public and are associated with increased recidivism and other mental and physical health issues. To evaluate the effects of Transcendental Meditation (TM) on trauma symptoms in male inmates. One hundred eighty-one inmates with a moderate - to high-risk criminal profile were randomly assigned to either the TM program or to a usual care control group. The Trauma Symptom Checklist and the Perceived Stress Scale were administered at baseline and four-month posttest. Significant reductions in total trauma symptoms, anxiety, depression, dissociation, and sleep disturbance subscales, and perceived stress in the TM group were found compared with controls (all p values < 0.001). The high - trauma subgroup analysis further showed a higher magnitude of effects in the TM group compared with controls on all outcomes, with Cohen effect sizes ranging from 0.67 to 0.89. Results are consistent with those of prior studies of the TM program in other populations and its effects on trauma symptoms and perceived stress. |
[
"B-T103",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"B-T058",
"I-T0... | [
{
"db_id": "C0003232",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0260127",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"SF2312",
"is",
"a",
"natural",
"phosphonate",
"inhibitor",
"of",
"enolase",
"Despite",
"being",
"crucial",
"for",
"energy",
"generation",
"in",
"most",
"forms",
"of",
"life",
",",
"few",
"if",
"any",
"microbial",
"antibiotics",
"specifically",
"inhibit",
"glyco... | [
[
0,
6
],
[
7,
9
],
[
10,
11
],
[
12,
19
],
[
20,
31
],
[
32,
41
],
[
42,
44
],
[
45,
52
],
[
53,
60
],
[
61,
66
],
[
67,
74
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[
75,
78
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[
79,
85
],
[
86... | SF2312 is a natural phosphonate inhibitor of enolase Despite being crucial for energy generation in most forms of life, few if any microbial antibiotics specifically inhibit glycolysis. To develop a specific inhibitor of the glycolytic enzyme enolase 2 (ENO2) for the treatment of cancers with deletion of ENO1 (encoding enolase 1), we modeled the synthetic tool compound inhibitor phosphonoacetohydroxamate (PhAH) into the active site of human ENO2. A ring-stabilized analog of PhAH, in which the hydroxamic nitrogen is linked to Cα by an ethylene bridge, was predicted to increase binding affinity by stabilizing the inhibitor in a bound conformation. Unexpectedly, a structure-based search revealed that our hypothesized backbone-stabilized PhAH bears strong similarity to SF2312, a phosphonate antibiotic of unknown mode of action produced by the actinomycete Micromonospora, which is active under anaerobic conditions. Here, we present multiple lines of evidence, including a novel X-ray structure, that SF2312 is a highly potent, low - nanomolar inhibitor of enolase. |
[
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"B-T092",
"I-T092",
"I-T092",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"B-T033... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0235974",
"db_name": "UMLS"
},
{
"db_id": "C0235974",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Improvement",
"in",
"advanced",
"pancreatic",
"cancer",
"survival",
"with",
"novel",
"chemotherapeutic",
"strategies",
"-",
"experience",
"of",
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"community",
"based",
"hospital",
"Background",
":",
"New",
"chemotherapeutic",
"strategies",
"for",
"locally",
"advan... | [
[
0,
11
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[
12,
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[
15,
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[
24,
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],
[
35,
41
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[
42,
50
],
[
51,
55
],
[
56,
61
],
[
62,
78
],
[
79,
89
],
[
90,
91
],
[
92,
102
],
[
103,
105
],
[
... | Improvement in advanced pancreatic cancer survival with novel chemotherapeutic strategies - experience of a community based hospital Background: New chemotherapeutic strategies for locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) have been shown to improve survival in randomized clinical trials. Little is known about the use of such chemotherapies and their benefit in community-based hospitals. This retrospective study analyzes the overall survival of these patients under " real life conditions " before and after the introduction of FOLFIRINOX in 2011. Methods: We retrospectively identified consecutive patients with PDAC who were treated at our hospital from 2011 to June 2014 (2011+ cohort) and 2004 to 2010 (historical cohort). Patients were included if PDAC was diagnosed in a locally advanced or metastatic state and at least 1 cycle of chemotherapy was given. Survival was assessed until April 2016. Patients with FOLFIRINOX were further analyzed regarding drug administration and side effects. Results: 128 patients met the inclusion criteria. Of the 74 patients in the historical cohort, 62 patients received Gemcitabine. Of the 54 patients diagnosed between 2011 and June 2014, 28 patients received FOLFIRINOX and 22 Gemcitabine as the first-line chemotherapy. Only 34 % of the patients in the historical cohort received a second-line chemotherapy in comparison to 69 % in the 2011+ cohort. Median overall survival (OS) showed a survival of 13.1 months (95 % CI; 11.6 - 14.5) for the 2011+ cohort compared to 9.6 months (95 % CI; 6.1 - 13.1) in the historical group. Conclusion: This study shows a marked improvement in survival of patients diagnosed with locally advanced or metastatic PDAC in a community-based hospital during the past 4 years. The most likely reasons are the use of new polychemotherapies like FOLFIRINOX and the use of second-line chemotherapy. |
[
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T038",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"B-T038",
"I-T038",
"O",
"O",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C2985436",
"db_name": "UMLS"
},
{
"db_id": "C2985436",
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},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id... | [
"Rare",
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"a",
"common",
",",
"complex",
"and",
"heritable",
"psychiatric",
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... | [
[
0,
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[
5,
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],
[
17,
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],
[
27,
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],
[
31,
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],
[
42,
46
],
[
47,
54
],
[
55,
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],
[
58,
65
],
[
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... | Rare deleterious mutations are associated with disease in bipolar disorder families Bipolar disorder (BD) is a common, complex and heritable psychiatric disorder characterized by episodes of severe mood swings. The identification of rare, damaging genomic mutations in families with BD could inform about disease mechanisms and lead to new therapeutic interventions. To determine whether rare, damaging mutations shared identity-by-descent in families with BD could be associated with disease, exome sequencing was performed in multigenerational families of the NIMH BD Family Study followed by in silico functional prediction. Disease association and disease specificity was determined using 5090 exomes from the Sweden - Schizophrenia (SZ) Population -Based Case- Control Exome Sequencing study. We identified 14 rare and likely deleterious mutations in 14 genes that were shared identity-by-descent among affected family members. The variants were associated with BD (P<0.05 after Bonferroni's correction) and disease specificity was supported by the absence of the mutations in patients with SZ. In addition, we found rare, functional mutations in known causal genes for neuropsychiatric disorders including holoprosencephaly and epilepsy. Our results demonstrate that exome sequencing in multigenerational families with BD is effective in identifying rare genomic variants of potential clinical relevance and also disease modifiers related to coexisting medical conditions. Replication of our results and experimental validation are required before disease causation could be assumed.Molecular Psychiatry advance online publication, 11 October 2016; doi:10.1038/mp.2016.181. |
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... | The Discrepancy between Patient and Clinician Reported Function in Extremity Bone Metastases Background. The Musculoskeletal Tumor Society (MSTS) scoring system measures function and is commonly used but criticized because it was developed to be completed by the clinician and not by the patient. We therefore evaluated if there is a difference between patient and clinician reported function using the MSTS score. Methods. 128 patients with bone metastasis of the lower (n = 100) and upper (n = 28) extremity completed the MSTS score. The MSTS score consists of six domains, scored on a 0 to 5 scale and transformed into an overall score ranging from 0 to 100% with a higher score indicating better function. The MSTS score was also derived from clinicians' reports in the medical record. Results. The median age was 63 years (interquartile range [IQR]: 55-71) and the study included 74 (58%) women. We found that the clinicians' MSTS score (median: 65, IQR: 49-83) overestimated the function as compared to the patient perceived score (median: 57, IQR: 40-70) by 8 points (p < 0.001). Conclusion. Clinician reports overestimate function as compared to the patient perceived score. This is important for acknowledging when informing patients about the expected outcome of treatment and for understanding patients' perceptions. |
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7... | Agency and Anxiety: Delusions of Control and Loss of Control in Schizophrenia and Agoraphobia We review the distinction between sense of agency and sense of ownership, and then explore these concepts, and their reflective attributions, in schizophrenic symptoms and agoraphobia. We show how the underlying dynamics of these experiences are different across these disorders. We argue that these concepts are complex and cannot be reduced to neural mechanisms, but involve embodied and situated processes that include the physical and social environments. We conclude by arguing that the subjective and intersubjective dimensions of agency and ownership cannot be considered in isolation from one another, but instead form an interdependent pairing. |
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... | Salmonella enterica serovar Typhi and gallbladder cancer: a case-control study and meta-analysis In Chile, where gallbladder cancer (GBC) rates are high and typhoid fever was endemic until the 1990s, we evaluated the association between Salmonella enterica serovar Typhi (S. Typhi) antibodies and GBC. We tested 39 GBC cases, 40 gallstone controls, and 39 population-based controls for S. Typhi Vi antibodies and performed culture and quantitative polymerase chain reaction for the subset with bile, gallstone, tissue, and stool samples available. We calculated gender and education-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association with GBC. We also conducted a meta-analysis of >1000 GBC cases by combining our results with previous studies. GBC cases were more likely to have high Vi antibody titer levels than combined controls (OR: 4.0, 95% CI: 0.9-18.3), although S. Typhi was not recovered from bile, gallstone, tissue, or stool samples. In our meta-analysis, the summary relative risk was 4.6 (95% CI: 3.1-6.8, P heterogeneity =0.6) for anti-Vi and 5.0 (95% CI: 2.7-9.3, P heterogeneity = 0.2) for bile or stool culture. Our results are consistent with the meta-analysis. Despite differences in study methods (e.g., S. Typhi detection assay), most studies found a positive association between S. Typhi and GBC. However, the mechanism underlying this association requires further investigation. |
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... | Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive Immunity NOD-like receptor (NLR) proteins, as much as Toll-like receptor proteins, play a major role in modulating myeloid cells in their immune functions. There is still, however, limited knowledge on the expression and function of several of the mammalian NLR proteins in myeloid lineages. Still, the function of pyrin domain -containing NLR proteins and NLRC4 / NAIP as inflammasome components that drive interleukin-1β (IL-1β) and IL-18 maturation and secretion upon pathogen stimulation is well established. NOD1, NOD2, NLRP3, and NLRC4 / NAIP act as bona fide pattern recognition receptors (PRRs) that sense microbe-associated molecular patterns (MAMPs) but also react to endogenous danger-associated molecular patterns (DAMPs). Ultimately, activation of these receptors achieves macrophage activation and maturation of dendritic cells to drive antigen-specific adaptive immune responses. Upon infection, sensing of invading pathogens and likely of DAMPs that are released in response to tissue injury is a process that involves multiple PRRs in both myeloid and epithelial cells, and these act in concert to design tailored, pathogen - adapted immune responses by induction of different cytokine profiles, giving rise to appropriate lymphocyte polarization. |
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8... | Social stress in adolescents induces depression and brain-region-specific modulation of the transcription factor MAX MAX is a conserved constitutive small phosphoprotein from a network of transcription factors that are extensively studied in tumorigenesis and whose functions affect cell proliferation, differentiation and death. Inspired by its higher expression during development and in regions involved in emotional behaviors, we hypothesized its involvement in cerebral changes caused by early-life stress. We studied the effects of repeated social stress during adolescence on behaviors and on MAX and its putative partner MYC. Thirty-day-old C57BL/6 male mice underwent brief daily social defeat stress from an adult aggressor for 21 days. Following social stress episodes and housing in social groups after each defeat, adolescent mice exhibit depressive -like, but not anxiety -like behaviors and show higher MAX nuclear immunoreactivity in hippocampal (HC) but not prefrontal cortical (PFC) neurons. Conversely, MAX immunoreactivity is lower in the striatum (ST) of defeated adolescents. The positive correlation between MAX and MYC levels in the PFC revealed disruptions in both the HC and ST. The changes in MAX protein levels are not due to differential gene expression or protein degradation in those regions, suggesting that posttranscriptional modifications occurred. These findings indicate that repeated, brief social defeat in adolescent male mice, combined with group housing, is a useful protocol to study a subtype of depression that is dissociated from generalized (non-social) anxiety. To our knowledge, this is the first report of an association between dysregulation of the MAX - MYC network in the brain and a behavior, suggesting a novel approach for exploiting the neuroplasticity associated with depression. |
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7... | Gas assisted method synthesis nitrogen-doped carbon quantum dots and Hg (II) sensing Nitrogen-doped fluorescent carbon quantum dots (CQDs) was prepared by gas-assisted method using cellulose as precursors under ammonia atmosphere, which not only exhibited excellent photoluminescent properties, but also showed highly selective and sensitive detection of mercury ion. The nitrogen-doped CQDs displayed excitation wavelength dependent fluorescent behavior with outstanding dispersibility. Moreover, they exhibited high tolerance to various external conditions, such as storage time, pH value, and ionic strength. The rapid detection of Hg (II) by one-step operation within 1 min and the good linear correlation between I0/I and Hg (II) concentration in the range of 10-100 nM made the nitrogen-doped CQDs a promising nanoprobe for Hg (II) detection. The detection limit of the nitrogen-doped CQDs is about 7.7 nM. Such a nanoprobe has been successfully applied for the analysis of Hg (II) in natural water samples, demonstrating excellent practical feasibility. |
[
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8... | Lower perinatal mortality in preterm born twins than in singletons: a nationwide study from The Netherlands Twin pregnancies are at increased risk for perinatal morbidity and death because of many factors that include a high incidence of preterm delivery. Compared with singleton pregnancies, overall perinatal risk of death is higher in twin pregnancies; however, for the preterm period, the perinatal mortality rate has been reported to be lower in twins. The purpose of this study was to compare perinatal mortality rates in relation to gestational age at birth between singleton and twin pregnancies, taking into account socioeconomic status, fetal sex, and parity. We studied perinatal mortality rates according to gestational age at birth in 1,502,120 singletons pregnancies and 51,658 twin pregnancies without congenital malformations who were delivered between 2002 and 2010 after 28 weeks of gestation. Data were collected from the nationwide Netherlands Perinatal Registry. Overall the perinatal mortality rate in twin pregnancies (6.6/1000 infants) was higher than in singleton pregnancies (4.1/1000 infants). However, in the preterm period, the perinatal mortality rate in twin pregnancies was substantially lower than in singleton pregnancies (10.4 per 1000 infants as compared with 34.5 per 1000 infants, respectively) for infants who were born at <37 weeks of gestation; this held especially for antepartum deaths. After 39 weeks of gestation, the perinatal mortality rate was high er in twin pregnancies. Differences in parity, fetal sex, and socioeconomic status did not explain the observed differences in outcome. Overall the perinatal mortality rate was higher in twin pregnancies than in singleton pregnancies, which is most likely caused by the high preterm birth rate in twins and not by a higher mortality rate for gestation, apart from term pregnancies. During the preterm period, the antepartum mortality rate was much lower in twin pregnancies than in singleton pregnancies. We suggest that this might be partially due to a closer monitoring of twin pregnancies, which indirectly suggests a need for closer surveillance of singleton pregnancies. |
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... | Intracellular localization of Saffold virus Leader (L) protein differs in Vero and HEp-2 cells The Saffold virus (SAFV) genome is translated as a single long polyprotein precursor and co-translationally cleaved to yield 12 separate viral proteins. Little is known about the activities of SAFV proteins although their homologs in other picornaviruses have already been described. To further support research on functions and activities of respective viral proteins, we investigated the spatio-temporal distribution of SAFV proteins in Vero and HEp-2 cells that had been either transfected with plasmids that express individual viral proteins or infected with live SAFV. Our results revealed that, with the exception of the Leader (L) protein, all viral proteins were localized in the cytoplasm at all the time points assayed. The L protein was found in the cytoplasm at an early time point but was subsequently translocated to the nucleus of HEp-2, but not Vero, cells. This was observed in both transfected and infected cells. Further mutational analysis of L protein revealed that Threonine 58 of the Ser / Thr -rich domain of L protein is crucial for protein trafficking between the cytoplasm and nucleus in HEp-2 cells. These findings contribute to a deeper understanding and stimulate investigation of the differetial cellular responses of HEp-2 cells in comparison to other mammalian cell lines during SAFV infection. |
[
"B-T062",
"O",
"B-T038",
"O",
"O",
"O",
"B-T082",
"B-T017",
"O",
"O",
"O",
"B-T204",
"I-T204",
"I-T204",
"I-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C0242481",
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{
"db_id": null,
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{
"db_id": "C0020202",
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{
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{
"db_id... | [
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... | Assessment of interbreeding and introgression of farm genes into a small Scottish Atlantic salmon Salmo salar stock: ad hoc samples - ad hoc results? An eclectic set of tissues and existing data, including purposely collected samples, spanning 1997-2006, was used in an ad hoc assessment of hybridization and introgression of farmed wild Atlantic salmon Salmo salar in the small Loch na Thull (LnT) catchment in north-west Scotland. The catchment is in an area of marine farm production and contains freshwater smolt rearing cages. The LnT S. salar stock was found to be genetically distinctive from stocks in neighbouring rivers and, despite regular reports of feral farm S. salar, there was no evidence of physical or genetic mixing. This cannot be completely ruled out, however, and low level mixing with other local wild stocks has been suggested. The LnT population appeared underpinned by relatively smaller effective number of breeders (Neb) and showed relatively low levels of genetic diversity, consistent with a small effective population size. Small sample sizes, an incomplete farm baseline and the use of non-diagnostic molecular markers, constrain the power of the analysis but the findings strongly support the LnT catchment having a genetically distinct wild S. salar population little affected by interbreeding with feral farm escapes. |
[
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"I-T098",
"O",
"B-T058",
"I-T058",
"O",
"O",
"B-T092",
"I-T092",
"O",
"O",
"B-T082",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"B-T092",
"O",
"O",
"O",
"B-T092",
"I-T092",
"O",
"O",
"O",... | [
{
"db_id": "C0442027",
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},
{
"db_id": null,
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{
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"db_id": null,
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{
"db_id": null,
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"db_id": null,... | [
"Oral",
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7... | Oral health-related quality of life in the elderly population receiving health care at the public hospital network in Medellín, Colombia, and its related factors Metrosalud is the largest public hospital network in the city of Medellin and one of the most important in Colombia providing health care to the most vulnerable population. The objective of the study was to determine the Oral HealthRelated Quality of Life (OHRQoL) and its related factors in the elderly population receiving health care at the public hospital network in Medellin (Colombia). A crosssectional design was used. Men and women ≥ 65 years old were considered for this research, selected from first consultation records by the institution's statistical unit for 2011, who accepted to participate after being contacted by telephone. Sampling was performed in two stages: simple random sampling for selecting Hospital Units HU and Health Centers HC throughout the hospital network in the city, followed by random quota sampling in proportion to the number of elderly population assigned to each HU and HC. A total 342 patients (58.2% women) participated in the study. The project involved the use of a structured questionnaire and complete dental examination with information on sociodemographic data, selfperceived health variables (mental, general and oral), use of oral health services, Oral HealthRelated Quality of Life (OHRQoL as measured with GOHAI index), temporomandibular joint test, oral mucosa, soft tissue evaluation, periodontal, dental and prosthetic examination. Descriptive and bivariate analyses were conducted to determine statistically significant differences. Multivariate analysis was performed, using logistic regression, calculating crude and adjusted odds ratios (OR) with their 95% confidence intervals (95% CI). Impacts were found to be generated by education levels, differences in socioeconomic status and urban or rural housing conditions. The results of this research show low OHRQoL levels in the elderly population receiving health care services at the public hospital network in Medellin. |
[
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"B-T038",
"B-T017",
"O",
"B-T038",
"I-T038",
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"O",
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"O",
"B-T103",
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"I-T103",
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"I-T103",
"I-T103",
"O",
"B-T038",
"B-T017",
"O",
"O",
"B-T058",
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"B-T038",
"I... | [
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{
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"db_id": "C0016360",
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{
"db_id": "C0016360",
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... | [
"Molecular",
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... | Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma This study addresses involvement of major 5-fluorouracil (5-FU) pathway genes in the prognosis of colorectal carcinoma patients. Testing set and two validation sets comprising paired tumor and adjacent mucosa tissue samples from 151 patients were used for transcript profiling of 15 5-FU pathway genes by quantitative real-time PCR and DNA methylation profiling by high resolution melting analysis. Intratumoral molecular profiles were correlated with clinical data of patients. Protein levels of two most relevant candidate markers were assessed by immunoblotting. Downregulation of DPYD and upregulation of PPAT, UMPS, RRM2, and SLC29A1 transcripts were found in tumors compared to adjacent mucosa in testing and validation sets of patients. Low RRM2 transcript level significantly associated with poor response to the first-line palliative 5-FU -based chemotherapy in the testing set and with poor disease-free interval of patients in the validation set irrespective of 5-FU treatment. UPP2 was strongly methylated while its transcript absent in both tumors and adjacent mucosa. DPYS methylation level was significantly higher in tumor tissues compared to adjacent mucosa samples. Low intratumoral level of UPB1 methylation was prognostic for poor disease-free interval of the patients (P = 0.0002). The rest of the studied 5-FU genes were not methylated in tumors or adjacent mucosa. The observed overexpression of several 5-FU activating genes and DPYD downregulation deduce that chemotherapy naïve colorectal tumors share favorable gene expression profile for 5-FU therapy. Low RRM2 transcript and UPB1 methylation levels present separate poor prognosis factors for colorectal carcinoma patients and should be further investigated. |
[
"B-T103",
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"I-T017",
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"B-T017",
"I-T017",
"I-T017",
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"I-T038",
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"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
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"O",
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"I-T017",
"I-T017",
"O",
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"O",
"B-T058",
"... | [
{
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"db_id": null,
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{
"db_id": "C3896693",
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{
"db_id": "C3896693",
"db_name": "UMLS"
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{
"db_id": "C3896693",
"db_name": "U... | [
"Osthole",
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8... | Osthole Protects Bone Marrow-Derived Neural Stem Cells from Oxidative Damage through PI3K/Akt-1 Pathway In recent years, neural stem cell (NSC) transplantation has been widely explored as a treatment for neurodegenerative diseases. NSCs are special cells that have some capacity for self-renewal and the potential to differentiate into multiple cell types. However, the inflammatory environment of diseased tissue is not conducive to the survival of transplanted cells. Osthole (Ost) is a principal bioactive component of Fructus Cnidii, Radix Angelicae Pubescentis and other traditional Chinese medicines. Ost has a wide range of pharmacological activities, such as anti-inflammation, immunomodulation, and neuroprotection. In the present study, we assessed the protective effects of Ost on bone marrow-derived - NSCs (BM - NSCs) against injury induced by hydrogen peroxide (H2O2). BM - NSCs were pre - treated with different doses of Ost and treated with H2O2. The cell counting kit-8 (CCK-8) method and lactate dehydrogenase (LDH) leakage assay were used to determine cell viability. Using the TUNEL assay and RT-PCR, we evaluated the effect of Ost on cell apoptosis. The results showed that Ost had protective effects against H2O2 - induced cell damage, and the number of apoptotic cells was significantly decreased in the Ost pre - treated groups compared to the H2O2 group. The expression ratio of Bax/Bcl-2 mRNA was also decreased. Furthermore, western blotting was used to analyze levels of proteins related to PI3K/Akt-1 signaling pathway, and results indicated that ost can increase p-Akt and PI3K. Our findings suggested that Ost protects BM - NSCs against oxidative stress injury, and it can be used to improve the inflammatory environment of neurodegenerative diseases so and promote the survival rate of transplanted NSCs. |
[
"B-T038",
"O",
"B-T204",
"O",
"B-T017",
"I-T017",
"I-T017",
"O",
"B-T103",
"O",
"O",
"B-T038",
"O",
"B-T033",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"B-T033",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T204",
"B-T204",
"O",
"O",
"B-T168",
"I-T168",
"O",
"O... | [
{
"db_id": "C0040684",
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{
"db_id": null,
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{
"db_id": "C1261477",
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{
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{
"db_id": "C0017337",
"db_name": "UMLS"
},
{
"db_id": "C0017337",
"db_name": "UMLS"
}... | [
"Transformation",
"of",
"Lettuce",
"with",
"rol",
"ABC",
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"... | [
[
0,
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15,
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18,
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31,
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35,
38
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39,
44
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[
44,
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[
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54
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60,
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69,
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... | Transformation of Lettuce with rol ABC Genes: Extracts Show Enhanced Antioxidant, Analgesic, Anti-Inflammatory, Antidepressant, and Anticoagulant Activities in Rats Lettuce is an edible crop that is well known for dietary and antioxidant benefits. The present study was conducted to investigate the effects of rol ABC genes on antioxidant and medicinal potential of lettuce by Agrobacterium -mediated transformation. Transgene integration and expression was confirmed through PCR and real-time RT-PCR, respectively. The transformed plants showed 91-102 % increase in total phenolic contents and 53-65 % increase in total flavonoid contents compared to untransformed plants. Total antioxidant capacity and total reducing power increased up to 112 and 133 % in transformed plants, respectively. Results of DPPH assay showed maximum 51 % increase, and lipid peroxidation assay exhibited 20 % increase in antioxidant activity of transformed plants compared to controls. Different in vivo assays were carried out in rats. The transgenic plants showed up to 80 % inhibition in both hot plate analgesic assay and carrageenan - induced hind paw edema test, while untransformed plants showed only 45 % inhibition. Antidepressant and anticoagulant potential of transformed plants was also significantly enhanced compared to untransformed plants. Taken together, the present work highlights the use of rol genes to enhance the secondary metabolite production in lettuce and improve its analgesic, anti-inflammatory, antidepressant, and anticoagulatory properties. |
[
"B-T062",
"O",
"O",
"O",
"O",
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"I-T103",
"I-T103",
"O",
"B-T038",
"I-T038",
"B-T103",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T017",
"I-T017... | [
{
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{
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{
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{
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{
"db_id": "C0110610",
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"db_id... | [
"Analysis",
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[
0,
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[
9,
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[
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[
36,
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[
39,
43
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[
43,
44
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[
44,
48
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[
49,
51
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[
52,
58
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[
59,
68
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[
69,
73
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[
74,
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7... | Analysis of Pathological Activities of CCN2/CTGF in Muscle Dystrophy CCN2 or connective tissue growth factor (CTGF) is a matricellular protein that regulates several cellular processes. In skeletal muscle, CTGF is a key modulator of fibrogenesis, is increased in pathological conditions such as muscular dystrophies, and plays a major role in the pathology outcome. Overexpression of CTGF in skeletal muscle of wild-type mice results in muscle damage, fibrosis, and reduction of strength. In contrast, a decrease in CTGF in dystrophic mice increases strength and reduces damage and fibrosis. Thus, CTGF is a relevant target to study in skeletal muscle pathology and its possible modulation by different treatments or potential new drugs to develop new strategies for the treatment of muscular dystrophies. We summarize the techniques used to detect CTGF in the skeletal muscle of dystrophic mdx mice. |
[
"B-T038",
"O",
"B-T017",
"O",
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"O",
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"B-T204",
"I-T204",
"O",
"B-T204",
"O",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"B-T204",
"I-T204",
"O... | [
{
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{
"db_id": "C0206524",
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{
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{
"db_id": null,
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"db_id... | [
"Transformation",
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"... | [
[
0,
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18,
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30,
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35,
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[
36,
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[
43,
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53,
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72,
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75,
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80,
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... | Transformation of plastids in soil -shaded lowermost hypocotyl segments of bean (Phaseolus vulgaris) during a 60- day cultivation period. The maintenance but substantial transformation of plastids was found in lowermost hypocotyl segments of soil -grown bean plants (Phaseolus vulgaris cv. Magnum) during a 60- day cultivation period. Although the plants were grown under natural light-dark cycles, this hypocotyl segment was under full coverage of the soil in 5-7 cm depth, thus it was never exposed to light. The 4- day -old plants were fully etiolated: amyloplasts, occasionally prolamellar bodies, protochlorophyllide (Pchlide) and protochlorophyll (Pchl) were found in the hypocotyls of these young seedlings. The 633 and 654 nm bands in the 77 K fluorescence emission spectra indicated the presence of Pchlide and Pchl pigments. During aging, both the Pchlide and Pchl contents increased, however, the Pchl to Pchlide ratio gradually increased. In parallel, the contribution of the 654 nm form decreased and in the spectra of the 60- day -old samples, the main band shifted to 631 nm, and a new form appeared with an emission maximum at 641 nm. The photoactivity had been lost; bleaching took place at continuous illumination. The inner membranes of the plastids disappeared, the amount of starch storing amyloplasts decreased. These data may indicate the general importance of plastids for plant cell metabolism, which can be the reason for their maintenance. Also the general heterogeneity of plastid forms can be concluded: in tissues not exposed to light, Pchl accumulating plastids develop and are maintained even for a long period. |
[
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"I-T103",
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"B-T103",
"I-T103",
"I-T103",
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"B-T204",
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"O",
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"O",
"O",
"O",
"B-T204",
"O",
"O",
"B-T082",
"I-T082",
"O",
"B-T082"... | [
{
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{
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"edible",
... | [
[
0,
3
],
[
4,
11
],
[
12,
16
],
[
17,
21
],
[
21,
22
],
[
22,
34
],
[
35,
45
],
[
46,
53
],
[
54,
68
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[
68,
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[
69,
70
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[
71,
74
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[
75,
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[
7... | New sterols with anti-inflammatory potentials against cyclooxygenase-2 and 5-lipoxygenase from Paphia malabarica Marine bivalves occupy a leading share in the total edible molluscs at the coastline regions of south-eastern Asia, and are found to possess significant nutritional and biological potential. Various in vitro evaluation (antioxidant and anti-inflammatory) guided purification of ethyl acetate - methanol (EtOAc - MeOH) extract of bivalve clam, Paphia malabarica characterised two new sterol derivatives as 23-gem-dimethylcholesta-5-en-3β-ol (1) and (22E)-24(1),24(2)-methyldihomocholest-5,22-dien-3β-ol (2) collected from the south-west coast of Arabian Sea. Their structures were unambiguously assigned on the basis of 1D, 2D NMR spectroscopy and mass spectrometry. The antioxidant and anti-inflammatory activities of 2 as determined by DPPH / ABTS(+) radical scavenging and anti- cyclooxygenase-2 / 5-lipoxygenase assays were significantly greater (IC50 < 1 mg/mL) than 1 (IC50 > 1 mg/mL). Structure-activity relationship analysis revealed that the bioactivities of these compounds were directly proportional to the electronic and lipophilic parameters. This is the first report of the occurrence and characterisation of 23-gem-dimethyl-3β-hydroxy-Δ(5)-cholestane nucleus and C-30 dihomosterol from marine organisms. |
[
"B-T058",
"B-T033",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"B-T058",
"B-T033",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T058",
"B-T033",
"O",
"O",
"O",
"B-T058",
"B-T033",
"O",
"O",
"O",
"B-T033",
"O",
"B-... | [
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{
"db_id": "C0243095",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id": "C0269169",
"db_name": "UMLS"
},
{
"db_id": "C0269169",
"db_name": "UMLS"
}... | [
"MRI",
"findings",
"of",
"isolated",
"tubal",
"torsions",
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"case",
"series",
"of",
"12",
"patients",
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"MRI",
"findings",
"suggesting",
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"tubal",
"torsions",
",",
"correlating",
"with",
"surgical",
"findings",
"To",
"investigate",
"specific",
"... | [
[
0,
3
],
[
4,
12
],
[
13,
15
],
[
16,
24
],
[
25,
30
],
[
31,
39
],
[
39,
40
],
[
41,
45
],
[
46,
52
],
[
53,
55
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[
56,
58
],
[
59,
67
],
[
67,
68
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[
6... | MRI findings of isolated tubal torsions: case series of 12 patients: MRI findings suggesting isolated tubal torsions, correlating with surgical findings To investigate specific MRI findings for the prompt diagnosis of tubal torsion by reviewing 12 cases. The MRI findings presenting surgically and pathologically proven isolated tubal torsion were evaluated. Key specific findings, including whirlpool sign and plicae tubaliae, were frequently associated with the diseases and were grouped for three types. Knowledge of specific MRI findings and the types of tubal torsion may lead to a correct and prompt diagnosis, resulting in preservation of fertility. |
[
"B-T103",
"I-T103",
"O",
"B-T204",
"I-T204",
"B-T103",
"O",
"O",
"B-T170",
"I-T170",
"I-T170",
"B-T103",
"I-T103",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"... | [
{
"db_id": "C0444626",
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},
{
"db_id": "C0444626",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0036025",
"db_name": "UMLS"
},
{
"db_id": "C0036025",
"db_name": "UMLS"
},
{
"db_id": "C0033684",
"db_name": "U... | [
"Crystal",
"Structure",
"of",
"Saccharomyces",
"cerevisiae",
"ECM4",
",",
"a",
"Xi",
"-",
"Class",
"Glutathione",
"Transferase",
"that",
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"Glutathionyl",
"-",
"(",
"hydro",
")",
"quinones",
"Glutathionyl",
"-",
"hydroquinone",
"reductases",
"(",
... | [
[
0,
7
],
[
8,
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],
[
18,
20
],
[
21,
34
],
[
35,
45
],
[
46,
50
],
[
50,
51
],
[
52,
53
],
[
54,
56
],
[
56,
57
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[
57,
62
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[
63,
74
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[
75,
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[
8... | Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones Glutathionyl-hydroquinone reductases (GHRs) belong to the recently characterized Xi-class of glutathione transferases (GSTXs) according to unique structural properties and are present in all but animal kingdoms. The GHR ScECM4 from the yeast Saccharomyces cerevisiae has been studied since 1997 when it was found to be potentially involved in cell-wall biosynthesis. Up to now and in spite of biological studies made on this enzyme, its physiological role remains challenging. The work here reports its crystallographic study. In addition to exhibiting the general GSTX structural features, ScECM4 shows extensions including a huge loop which contributes to the quaternary assembly. These structural extensions are probably specific to Saccharomycetaceae. Soaking of ScECM4 crystals with GS-menadione results in a structure where glutathione forms a mixed disulfide bond with the cysteine 46. Solution studies confirm that ScECM4 has reductase activity for GS-menadione in presence of glutathione. Moreover, the high resolution structures allowed us to propose new roles of conserved residues of the active site to assist the cysteine 46 during the catalytic act. |
[
"B-T033",
"I-T033",
"B-T062",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
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... | [
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{
"db_id": "C0936012",
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{
"db_id": null,
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},
{
"db_id": "C0686619",
"db_name": "UMLS"
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{
"db_id": "C0686619",
"db_name": "U... | [
"Risk",
"factors",
"analyses",
"for",
"lateral",
"lymph",
"node",
"metastases",
"in",
"papillary",
"thyroid",
"carcinomas",
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"in... | [
[
0,
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22,
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40,
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45,
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56,
58
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69,
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87,
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8... | Risk factors analyses for lateral lymph node metastases in papillary thyroid carcinomas: a retrospective study of 356 patients The aim of this study was to investigate the incidence and risk factors for lateral lymph node metastasis (LLNM) in patients with papillary thyroid carcinoma (PTC). 356 patients diagnosed with PTC who underwent total thyroidectomy and central lymph node dissection and lateral lymph node dissection between January 2005 and December 2011 were enrolled. The relation between LLNM and clinicopathological features such as gender, age, tumor size, tumor spread, psammoma bodies, tumor multifocality, extrathyroidal extension (ETE), unilateral or bilateral disease, tumor primary location and central lymph node metastases (CLNM) was analyzed. The rate of LLNM was 75.0%. In the univariate analysis, it was significantly associated with age, tumor size, tumor spread, extrathyroidal extension, primary tumor location and central lymph node metastasis (p < 0.05). In contrast, in the multivariate analysis, it was significantly associated with primary tumor location, central lymph node metastasis (p < 0.05) and tumor size > 1.5 cm with p = 0.05 but was unrelated to the other factors. Patients with PTC, with the primary tumor located in the upper part of the lobe and positive central compartment lymph node metastasis with a tumor size > 1.5 cm diameter are more likely to have LLNM. Therefore, more meticulous evaluations including the lateral lymph nodes should be performed before surgery. |
[
"B-T103",
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"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T037",
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"B-T204",
"B-T017",
"O",
"O",
"O",
"O",
"B-T058",
"B-T170",
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"B-T168",
"B-T103",
"B-T058",
"B-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"B-T098",
"O"... | [
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{
"db_id": "C1254351",
"db_name": "UMLS"
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{
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{
"db_id": "C0057445",
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{
"db_id": null,
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{
"db_id": null,
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{
... | [
"Mycotoxin",
"detoxifiers",
"attenuate",
"deoxynivalenol",
"-",
"induced",
"pro",
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"inflammatory",
"barrier",
"insult",
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"reduction",
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[
0,
9
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[
10,
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22,
31
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[
32,
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47,
48
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49,
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[
57,
60
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[
60,
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[
74,
81
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[
82,
88
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[
89,
91
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[
92,
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... | Mycotoxin detoxifiers attenuate deoxynivalenol - induced pro-inflammatory barrier insult in porcine enterocytes as an in vitro evaluation model of feed mycotoxin reduction Deoxynivalenol (DON), the most prevalent mycotoxin worldwide, leads to economic losses for animal food production. Swine is a most sensitive domestic animal to DON due to rapid absorption and low detoxification by gut microbiota. Specifically, DON can severely damage pig intestinal tissue by disrupting the intestinal barrier and inducing inflammatory responses. We evaluated the effects of several mycotoxin detoxifiers including bentonites, yeast cell wall components, and mixture-typed detoxifier composed of mineral, microorganisms, and phytogenic substances on DON - insulted intestinal barrier and pro-inflammatory responses using in vitro porcine enterocyte culture model. DON - induced disruption of the in vitro gut barrier was attenuated by all three mycotoxin detoxifiers in dose-dependent manners. These mycotoxin detoxifiers also suppressed DON - induced pro-inflammatory chemokine expression to different degrees, which was mediated by downregulation of mitogen-activated kinases and early growth response-1. Of note, the mixture-typed detoxifier was the most prominent mitigating agent at the cellular levels whereas the high dose of bentonite clay also had suppressive action against DON - induced pro-inflammatory insult. The in vitro porcine enterocyte-based assessment of intestinal barrier integrity and inflammatory signals provides sensitive and simplified alternative bioassay of feed additives such as detoxifiers against enteropathogenic mycotoxins with comprehensive mechanistic confirmation. |
[
"B-T058",
"I-T058",
"O",
"B-T103",
"B-T058",
"O",
"B-T037",
"I-T037",
"I-T037",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"B-T103",
"O",
"O",
"B-T103",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T037",
"I-T0... | [
{
"db_id": "C0870300",
"db_name": "UMLS"
},
{
"db_id": "C0870300",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0072642",
"db_name": "UMLS"
},
{
"db_id": "C0087111",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
}... | [
"Cognitive",
"assessment",
"of",
"pycnogenol",
"therapy",
"following",
"traumatic",
"brain",
"injury",
"We",
"have",
"previously",
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"that",
"pycnogenol",
"(",
"PYC",
")",
"increases",
"antioxidants",
",",
"decreases",
"oxidative",
"stress",
",",
"suppresses"... | [
[
0,
9
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[
10,
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[
21,
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],
[
24,
34
],
[
35,
42
],
[
43,
52
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[
53,
62
],
[
63,
68
],
[
69,
75
],
[
76,
78
],
[
79,
83
],
[
84,
94
],
[
95,
100
],
[
... | Cognitive assessment of pycnogenol therapy following traumatic brain injury We have previously shown that pycnogenol (PYC) increases antioxidants, decreases oxidative stress, suppresses neuroinflammation and enhances synaptic plasticity following traumatic brain injury (TBI). Here, we investigate the effects of PYC on cognitive function following a controlled cortical impact (CCI). Adult Sprague-Dawley rats received a CCI injury followed by an intraperitoneal injection of PYC (50 or 100mg/kg). Seven days post trauma, subjects were evaluated in a Morris water maze (MWM) and evaluated for changes in lesion volume. Some animals were evaluated at 48h for hippocampal Fluoro-jade B (FJB) staining. The highest dose of PYC therapy significantly reduced lesion volume, with no improvement in MWM compared to vehicle controls. PYC failed to reduce the total number of FJB positive neurons in the hippocampus. These results suggest that the reduction of oxidative stress and neuroinflammation are not the key components of the secondary injury that contribute to cognitive deficits following TBI. |
[
"B-T103",
"O",
"B-T038",
"B-T038",
"I-T038",
"B-T038",
"I-T038",
"O",
"B-T103",
"B-T033",
"O",
"B-T204",
"I-T204",
"O",
"B-T204",
"I-T204",
"I-T204",
"I-T204",
"O",
"B-T204",
"O",
"B-T038",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"I-T017",
... | [
{
"db_id": "C0031603",
"db_name": "UMLS"
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{
"db_id": null,
"db_name": null
},
{
"db_id": "C1327622",
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{
"db_id": "C1155275",
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},
{
"db_id": "C1155275",
"db_name": "UMLS"
},
{
"db_id": "C0017262",
"db_name": "U... | [
"Phosphate",
"availability",
"regulates",
"ethylene",
"biosynthesis",
"gene",
"expression",
"and",
"protein",
"accumulation",
"in",
"white",
"clover",
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"Trifolium",
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"L",
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"of",
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... | [
[
0,
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[
10,
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[
23,
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],
[
33,
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[
42,
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[
55,
59
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[
60,
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],
[
71,
74
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[
75,
82
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[
83,
95
],
[
96,
98
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[
99,
104
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[
105,
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... | Phosphate availability regulates ethylene biosynthesis gene expression and protein accumulation in white clover (Trifolium repens L.) roots The expression and accumulation of members of the 1-aminocyclopropane-1-carboxylate (ACC) synthase (ACS) and ACC oxidase (ACO) gene families was examined in white clover roots grown in either Pi (phosphate) sufficient or Pi -deprived defined media. The accumulation of one ACO isoform, TR-ACO1, was positively influenced after only 1 h of exposure to low Pi, and this was maintained over a 7- day time-course. Up-regulation of TR-ACS1, TR-ACS2 and TR-ACS3 transcript abundance was also observed within 1 h of exposure to low Pi in different tissue regions of the roots, followed by a second increase in abundance of TR-ACS2 after 5-7 days of exposure. An increase in transcript abundance of TR-ACO1 and TR-ACO3, but not TR-ACO2, was observed after 1 h of exposure to low Pi, with a second increase in TR-ACO1 transcripts occurring after 2-5 days. These initial increases of the TR-ACS and TR-ACO transcript abundance occurred before the induction of Trifolium repens PHOSPHATE TRANSPORTER 1 (TR-PT1), and the addition of sodium phosphite did not up-regulate TR-ACS1 expression over 24 h. In situ hybridization revealed some overlap of TR-ACO mRNA accumulation, with TR-ACO1 and TR-ACO2 in the root tip regions, and TR-ACO1 and TR-ACO3 mRNA predominantly in the lateral root primordia. TR-ACO1p -driven GFP expression showed that activation of the TR-ACO1 promoter was initiated within 24 h of exposure to low Pi (as determined by GFP protein accumulation). These results suggest that the regulation of ethylene biosynthesis in white clover roots is biphasic in response to low Pi supply. |
[
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"B-T098",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"B-T038",
"O",
"B-T007",
"I-T007",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"B-... | [
{
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"db_id": null,
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{
"db_id": "C0368903",
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"db_id": "C0368903",
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{
"db_id": "C0368903",
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{
"db_id": null,
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},
{
... | [
"Identification",
"of",
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"trachomatis",
"Antigens",
"Recognized",
"by",
"T",
"Cells",
"From",
"Highly",
"Exposed",
"Women",
"Who",
"Limit",
"or",
"Resist",
"Genital",
"Tract",
"Infection",
"Natural",
"infection",
"induces",
"partial",
"immunity",
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... | [
[
0,
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[
15,
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[
18,
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[
28,
39
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[
40,
48
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[
49,
59
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[
60,
62
],
[
63,
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[
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[
71,
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[
83,
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[
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... | Identification of Chlamydia trachomatis Antigens Recognized by T Cells From Highly Exposed Women Who Limit or Resist Genital Tract Infection Natural infection induces partial immunity to Chlamydia trachomatis Identification of chlamydial antigens that induce interferon γ (IFN-) secretion by T cells from immune women could advance vaccine development. IFN-γ production by CD4(+) and CD8(+) peripheral blood T cells from 58 high-risk women was measured after coculture with antigen-presenting cells preincubated with recombinant Escherichia coli expressing a panel of 275 chlamydial antigens. Quantile median regression analysis was used to compare frequencies of IFN-γ responses in women with only cervical infection to those in women with endometrial infection and frequencies in women who remained uninfected for over 1 year to those in women who developed incident infection. Statistical methods were then used to identify proteins associated with protection. A higher median frequency of CD8(+) T-cell responses was detected in women with lower genital tract chlamydial infection, compared with those with upper genital tract chlamydial infection (13.8% vs 9.5%; P =04), but the CD4(+) T-cell response frequencies were not different. Women who remained uninfected displayed a greater frequency of positive CD4(+) T-cell responses (29% vs 18%; P < .0001), compared with women who had incident infection, while the frequencies of CD8(+) T-cell responses did not differ. A subset of proteins involved in central metabolism, type III secretion, and protein synthesis were associated with protection. Investigations in naturally exposed women reveal protective responses and identify chlamydial vaccine candidate antigens. |
[
"B-T058",
"I-T058",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"B-T058",
"I-T058",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
... | [
{
"db_id": "C4289728",
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{
"db_id": "C4289728",
"db_name": "UMLS"
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{
"db_id": null,
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},
{
"db_id": "C2585653",
"db_name": "UMLS"
},
{
"db_id": "C2585653",
"db_name": "UMLS"
},
{
"db_id": "C2585653",
"db_name": "U... | [
"Cryoballoon",
"ablation",
"of",
"persistent",
"atrial",
"fibrillation",
":",
"feasibility",
"and",
"safety",
"of",
"left",
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"roof",
"ablation",
"with",
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"conduction",
"block",
"in",
"addition",
"to",
"antral",
"pulmonary",
"vein",
"iso... | [
[
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[
12,
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[
21,
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[
24,
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],
[
35,
41
],
[
42,
54
],
[
54,
55
],
[
56,
67
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[
68,
71
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[
72,
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[
79,
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[
82,
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[
87,
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[
... | Cryoballoon ablation of persistent atrial fibrillation: feasibility and safety of left atrial roof ablation with generation of conduction block in addition to antral pulmonary vein isolation Although the generation of linear lesions by ablation improves success rates in patients with persistent atrial fibrillation (AF), the procedure has been considered unsuitable for cryoablation balloon catheter technologies. We developed a technique for linear ablations, using second-generation cryoballoon technology. This was a single-arm, prospective study in 76 patients with persistent AF treated consecutively at our centre. Cryoablation was performed using a 28 mm second-generation cryoballoon. The first cryoenergy application was performed in close proximity to the position during isolation of the left superior pulmonary vein (PV). Sequential overlapping freezes were applied along the left atrial (LA) roof by slight clockwise rotation of the sheath in combination with slight retraction of the sheath and incremental advancement of the cryoballoon, until reaching the original position for right superior PV isolation. The acute endpoint was the creation of a roofline, defined as complete conduction block across the LA roof >120 ms and ascending activation across the posterior LA wall. Acute success in roofline generation was achieved in 88% of patients, applying on average five (median 4-6) freezes with nadir temperature of -40°C (-36 to -44°C). In five patients, conduction block could not be achieved. No phrenic nerve injuries occurred during roofline generation. Generation of linear roofline lesions is possible with the second-generation cryoballoon. The technique can be used in combination with PV isolation to treat persistent AF with good acute success rates, short procedure times, and acceptable safety concerns. If validated by further studies, the method would be an appealing alternative to radiofrequency ablation techniques. |
[
"B-T038",
"O",
"O",
"B-T017",
"I-T017",
"B-T017",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"B-T058",
"B-T038",
"O",
"O",
"O",
"B-T082",
"B-T017",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017"... | [
{
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"db_id": "C0036186",
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{
"db_id": "C0036186",
"db_name": "UMLS"
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{
"db_id": "C0002690",
"db_name": "UMLS"
}... | [
"Thrombosis",
"of",
"the",
"Saphenous",
"Vein",
"Stump",
"after",
"Varicose",
"Vein",
"Surgery",
"We",
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"6",
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0,
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39,
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45,
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... | Thrombosis of the Saphenous Vein Stump after Varicose Vein Surgery We evaluated thrombus extension in the proximal stump of the saphenous vein at 6 days, 4 weeks, and 16 weeks after saphenous vein surgery performed between July 2013 and March 2014 (18 patients, 29 limbs, and 31 stumps) using duplex ultrasonography. All thrombotic events were classified as endovenous heat-induced thrombosis (EHIT). Thrombus was observed in 27 stumps (87.1%), with only four (12.9%) stumps remaining without thrombus on postoperative day 6. Thrombus as EHIT class 2 was observed in one stump and as EHIT class 3 in another; in the remaining 25 stumps, it was observed as EHIT class 1 postoperatively. No further extension of thrombus was found at 4 and 16 weeks after surgery. The rate of thrombus formation in the proximal stump of the saphenous vein after conventional surgery is comparatively higher than that after thermoablation techniques. Further studies are required to determine adequate evaluation methods and appropriate therapies for stump thrombosis after varicose vein surgery. (This article is a translation of J Jpn Coll Angiol 2015; 55: 105-110). |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O... | [
{
"db_id": null,
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{
"db_id": null,
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"db_id": null,
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{
"db_id": null,
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{
"db_id": null,
"db... | [
"Outcomes",
"With",
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"Alone",
"Compared",
"With",
"Cerclage",
"Plus",
"17α",
"-",
"Hydroxyprogesterone",
"Caproate",
"To",
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"in",
"perinatal",
"outcomes",
"among",
"women",
"with",
"a",
"prior",
"preterm",
"birth",
"who",... | [
[
0,
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[
9,
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[
14,
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[
23,
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[
29,
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38,
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[
43,
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[
52,
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[
57,
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[
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[
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[
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9... | Outcomes With Cerclage Alone Compared With Cerclage Plus 17α-Hydroxyprogesterone Caproate To examine the differences in perinatal outcomes among women with a prior preterm birth who received cerclage compared with cerclage plus 17α-hydroxyprogesterone caproate. Women with transvaginal cerclage placement and a prior delivery between 16 and 36 weeks of gestation were identified over a 10- year period (July 2002 to May 2012) in this retrospective cohort study. Exclusion criteria were delivery at another institution, abdominal cerclage, multiple gestations, and major fetal anomalies. Maternal demographics, gestational age at cerclage, gestational age at delivery, preterm prelabor rupture of membranes (PROM), and birth weight were compared between women with a cerclage and cerclage plus 17α-hydroxyprogesterone caproate. The primary outcome was delivery at less than 24 weeks of gestation. Of the 411 women who had a cerclage, 260 met inclusion criteria. Of these, 171 received a cerclage alone and 89 received cerclage plus 17α-hydroxyprogesterone caproate. The two groups were not different with respect to maternal demographics and gestational age at cerclage. There was a significant difference among those who received indomethacin at the time of cerclage, betamethasone administration, and history of a loop electrosurgical excision procedure - cold knife cone and cerclage. Delivery at less than 24 weeks of gestation occurred in 6% of women receiving both 17α-hydroxyprogesterone caproate and cerclage compared with 16% in the cerclage only group (odds ratio [OR] 0.31, 95% confidence interval 0.10-0.78, P=.01). In the multivariate analysis controlling for indomethacin use, prior cerclage, and loop electrosurgical excision procedure - cold knife cone there was a 73% reduction in delivery in the combined treatment group compared with cerclage alone (adjusted OR 0.26, P=.02). A multivariant analysis was conducted with correction for indomethacin at the time of cerclage, prior cerclage, and loop electrosurgical excision procedure - cold knife cone and cerclage surgery. Even after controlling for significant variables, there remained a 73% reduction in delivery at less than 24 weeks of gestation in the cerclage plus 17α-hydroxyprogesterone caproate cohort (adjusted OR 0.26, P=.02). Women receiving transvaginal cerclage plus 17α-hydroxyprogesterone caproate had a 69% relative reduction in delivery at less than 24 weeks of gestation when compared with women receiving cerclage alone. We found no difference in overall preterm delivery or preterm PROM. In this cohort, compared with cerclage alone, the likelihood of a viable neonate improves with both treatments. |
[
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T033",
"I-T033",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O"... | [
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"db_id": null,
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{
"db_id": null,
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{
"db_id": "C0013080",
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{
"db_id": "C0013080",
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{
"db_id": null,
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"db_id... | [
"Observed",
"Rate",
"of",
"Down",
"Syndrome",
"in",
"Twin",
"Pregnancies",
"To",
"evaluate",
"the",
"observed",
"incidence",
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"compared",
"with",
"that",
"expected",
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"age",
"-",
"matched",
"sin... | [
[
0,
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[
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14,
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[
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[
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31,
33
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[
34,
38
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[
39,
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[
51,
53
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[
54,
62
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[
63,
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[
67,
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[
76,
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8... | Observed Rate of Down Syndrome in Twin Pregnancies To evaluate the observed incidence of Down syndrome in twins compared with that expected based on maternal age - matched singletons, which is the current clinical approach. This was a retrospective review of California Prenatal Screening Program participants with expected delivery dates between July 1995 and December 2012. Cases confirmed prenatally or postnatally with a genetic imbalance leading to phenotypic Down syndrome (trisomy 21, mosaic trisomy 21, or translocations) were included. Pregnancies conceived with ovum donation and women older than 45 years were excluded. We compared the observed Down syndrome incidence per pregnancy for twins with expected incidence by extrapolating from singleton data and expected zygosity as is the current clinical approach. This extrapolation assumes that monozygotic pregnancies have equivalent Down syndrome risk per pregnancy relative to maternal age - matched singletons and dizygotic pregnancies have twice the risk of at least one affected fetus. Zygosity for affected cases was presumed to be monozygotic with Down syndrome concordance and dizygotic with Down syndrome discordance. Counts were compared using cumulative Poisson distributions. Of 77,279 twin pregnancies, 182 (0.2%) had at least one fetus with Down syndrome confirmed by karyotype. The ratio of observed -to-expected Down syndrome incidence per pregnancy was 33.6%, 75.2%, and 70.0% for monozygotic, dizygotic, and all twins, respectively (P<.001 for all comparisons). Considering maternal age subgroups and twin zygosity, a significantly lower -than-expected Down syndrome incidence was seen for women aged 25 to 45 years with monozygotic pregnancies and overall for women aged 25 to 45 years with dizygotic pregnancies. The observed incidence of Down syndrome in twin pregnancies is lower than expected, most notably for monozygotic pregnancies and with increasing maternal age. Risk-based counseling can strongly affect women's choices regarding testing and management during pregnancy, so an understanding of the true Down syndrome risk in twin gestations is crucial. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T097",
"O",
"B-T097",
"O",
"B-T092",
"I-T092",
"O",
"B-T082",
"I-T082",
"O",
"O",
"B-T062",
"I-T062",
"I-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O... | [
{
"db_id": null,
"db_name": null
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{
"db_id": null,
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{
"db_id": null,
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{
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{
"db_id": null,
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{
"db_id": "C0026605",
... | [
"Can",
"performance",
"-",
"based",
"incentives",
"improve",
"motivation",
"of",
"nurses",
"and",
"midwives",
"in",
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[
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[
41,
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52,
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8... | Can performance-based incentives improve motivation of nurses and midwives in primary facilities in northern Ghana? A quasi-experimental study Lack of an adequate and well-performing health workforce has emerged as the biggest barrier to scaling up health services provision in sub-Saharan Africa. As the global community commits to the Sustainable Development Goals and universal health coverage, health workforce challenges are critical. In northern Ghana, performance-based incentives (PBIs) were introduced to improve health worker motivation and service quality. The goal of this study was to determine the impact of PBIs on maternal health worker motivation in two districts in northern Ghana. A quasi-experimental study design with pre- and post-intervention measurement was used. PBIs were implemented for 2 years in six health facilities in Kassena-Nankana District with six health facilities in Builsa District serving as comparison sites. Fifty pre- and post-intervention structured interviews and 66 post-intervention in-depth interviews were conducted with health workers. Motivation was assessed using constructs for job satisfaction, pride, intrinsic motivation, timelines / attendance, and organisational commitment. Quantitative data were analysed to determine changes in motivation between intervention and comparison facilities pre- and post-intervention using STATA™ version 13. Qualitative data were analysed thematically using NVivo 10 to explore possible reasons for quantitative findings. PBIs were associated with slightly improved maternal health worker motivation. Mean values for overall motivation between intervention and comparison health workers were 0.6 versus 0.7 at baseline and 0.8 versus 0.7 at end line, respectively. Differences at baseline and end line were 0.1 (p=0.40 and p=0.50 respectively), with an overall 0.01 difference in difference (p=0.90). Qualitative interviews indicated that PBIs encouraged health workers to work harder and be more punctual, increasing reported pride and job satisfaction. The results contribute evidence on the effects of PBIs on motivational constructs among maternal health workers in primary care facilities in northern Ghana. PBIs appeared to improve motivation, but not dramatically, and the long-term and unintended effects of their introduction require additional study. |
[
"O",
"O",
"O",
"B-T103",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T098",
"I-T098",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T098",
"I-T098",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0003289",
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id": "C001... | [
"The",
"association",
"between",
"antidepressant",
"use",
"and",
"hemoglobin",
"A1C",
"in",
"older",
"adults",
"Depression",
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"diabetes",
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"worsen",
"glycemic",
"control",
"in",
"older",
"adults",
",",
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[
0,
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[
4,
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[
16,
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24,
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43,
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[
47,
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[
58,
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[
62,
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[
65,
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[
71,
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[
78,
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9... | The association between antidepressant use and hemoglobin A1C in older adults Depression is known to increase diabetes risk and worsen glycemic control in older adults, who already experience high rates of diabetes. The independent impact of antidepressants on glucose control is less clear. Data was drawn from the Health and Retirement Study, a large nationally - representative longitudinal study of retired individuals. Crude and adjusted linear models stratified by diabetes status were used to examine the cross-sectional associations between antidepressant use categorized by subclass and continuous hemoglobin A1C. The sample included 1,153 individuals, most over the age of 70. Antidepressant use was not associated with hemoglobin A1C in any model whether stratified or in the total combined sample. Antidepressants as a class were also not associated with hemoglobin A1C. These findings add to the literature suggesting that antidepressants are not associated with diabetes risk or glycemic control. Prospective studies with larger sample sizes are needed to confirm this finding. |
[
"B-T033",
"I-T033",
"O",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T058",
"O",
"B-T033",
"I-T033",
"O",
"B-T017",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"... | [
{
"db_id": "C4021734",
"db_name": "UMLS"
},
{
"db_id": "C4021734",
"db_name": "UMLS"
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{
"db_id": null,
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},
{
"db_id": "C0028754",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
... | [
"Mitochondrial",
"dysfunction",
"in",
"obesity",
"-",
"related",
"kidney",
"disease",
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"a",
"novel",
"therapeutic",
"target",
"Lipid",
"accumulation",
"in",
"renal",
"cells",
"has",
"been",
"implicated",
"in",
"the",
"pathogenesis",
"of",
"obesity",
"-",
"re... | [
[
0,
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[
14,
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],
[
26,
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[
29,
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],
[
37,
38
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[
38,
45
],
[
46,
52
],
[
53,
60
],
[
60,
61
],
[
62,
63
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[
64,
69
],
[
70,
81
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[
82,
88
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... | Mitochondrial dysfunction in obesity -related kidney disease: a novel therapeutic target Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity -related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet -induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria - targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity -related kidney disease. |
[
"B-T103",
"O",
"B-T038",
"O",
"O",
"B-T103",
"O",
"B-T103",
"O",
"B-T103",
"B-T038",
"O",
"B-T038",
"I-T038",
"O",
"B-T204",
"B-T058",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"... | [
{
"db_id": "C0141783",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0085616",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": null,
"db_name": null
},
{
"db_id": "C0380568",
"db_name": "UMLS"
},
{
... | [
"Scutellarin",
"attenuates",
"vasospasm",
"through",
"the",
"Erk5",
"-",
"KLF2",
"-",
"eNOS",
"pathway",
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",",
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... | [
[
0,
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[
12,
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[
23,
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[
33,
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],
[
41,
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[
45,
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[
50,
51
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[
52,
56
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[
57,
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[
59,
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[
64,
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[
72,
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[
78,
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... | Scutellarin attenuates vasospasm through the Erk5 - KLF2 - eNOS pathway after subarachnoid hemorrhage in rats Angiographic vasospasm, especially in the early phases (<72h) of subarachnoid hemorrhage (SAH), is one of the major complications after an aneurysm rupture and is often the cause of delayed neurological deterioration. Scutellarin (SCU), a flavonoid extracted from the traditional Chinese herb Erigeron breviscapus, has been widely accepted as an antioxidant, but the effect of SCU on vasospasm after SAH remains elusive. Endovascular perforation was conducted to induce SAH in Sprague-Dawley rats. Then, the underlying mechanism of the anti-vasospasm effect of SCU was investigated using a modified Garcia scale, India ink angiography, cross-sectional area analysis, immunohistochemistry staining and western blot. SCU (50μM, 100mg/kg) alleviated angiographic vasospasm and improved neurological function 48h after SAH and enhanced the expression of endothelial nitric oxide synthase (eNOS) at the intima of cerebral arteries. In addition, SCU upregulated the expression of phosphorylated extracellular-regulated kinase 5 (p-Erk5) and Kruppel-like factor 2 (KLF2) at 48h after SAH. However, the effects of SCU were reversed by the Erk5 inhibitor XMD8-92. Our results indicate that SCU could attenuate vasospasm and neurological deficits via modulating the Erk5 - KLF2 - eNOS pathway after SAH, which may provide an experimental basis for the clinical use of SCU treatment in SAH patients. |
[
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"B-T082",
"O",
"O",
"B-T062",
"I-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
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"db_id": "C0184666",
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"db_id... | [
"Predicting",
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... | Predicting frequent hospital admission risk in Singapore: a retrospective cohort study to investigate the impact of comorbidities, acute illness burden and social determinants of health To evaluate the impact of comorbidities, acute illness burden and social determinants of health on predicting the risk of frequent hospital admissions. Multivariable logistic regression was used to associate the predictive variables extracted from electronic health records and frequent hospital admission risk. The model's performance of our predictive model was evaluated using a 10-fold cross-validation. A single tertiary hospital in Singapore. All adult patients admitted to the hospital between 1 January 2013 and 31 May 2014 (n=25 244). Frequent hospital admissions, defined as 3 or more inpatient admissions within 12 months of discharge. Ar ea under the receiver operating characteristic curve (AUC) of the predictive model, and the sensitivity, specificity and positive predictive values for various cut-offs. 4322 patients (17.1%) met the primary outcome. 11 variables were observed as significant predictors and included in the final regression model. The strongest independent predictor was treatment with antidepressants in the past 1 year (adjusted OR 2.51, 95% CI 2.26 to 2.78). Other notable predictors include requiring dialysis and treatment with intravenous furosemide during the index admission. The predictive model achieved an AUC of 0.84 (95% CI 0.83 to 0.85) for predicting frequent hospital admission risk, with a sensitivity of 73.9% (95% CI 72.6% to 75.2%), specificity of 79.1% (78.5% to 79.6%) and positive predictive value of 42.2% (95% CI 41.1% to 43.3%) at the cut-off of 0.235. We have identified several predictors for assessing the risk of frequent hospital admissions that achieved high discriminative model performance. Further research is necessary using an external validation cohort. |
[
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... | [
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... | HieranoiDB: a database of orthologs inferred by Hieranoid HieranoiDB (http://hieranoiDB.sbc.su.se) is a freely available on-line database for hierarchical groups of orthologs inferred by the Hieranoid algorithm. It infers orthologs at each node in a species guide tree with the InParanoid algorithm as it progresses from the leaves to the root. Here we present a database HieranoiDB with a web interface that makes it easy to search and visualize the output of Hieranoid, and to download it in various formats. Searching can be performed using protein description, identifier or sequence. In this first version, orthologs are available for the 66 Quest for Orthologs reference proteomes. The ortholog trees are shown graphically and interactively with marked speciation and duplication nodes that show the inferred evolutionary scenario, and allow for correct extraction of predicted orthologs from the Hieranoid trees. |
[
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"B-T038",
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"I-T038",... | [
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{
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"db_id... | [
"A",
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6... | A Necrotizing Fasciitis Fake Out on Point-of-Care Ultrasound -Watch the Shadow Point-of-care ultrasound has an increasing role in characterizing soft-tissue infections and has been described previously in the evaluation of necrotizing fasciitis (NF). The identification of air within the soft tissues can be very suggestive of NF in the correct clinical context. A 78-year-old male presented to the emergency department with extensive lower-extremity redness and edema. A point-of-care ultrasound revealed hyperechoic areas within the soft tissues consistent with air, and the patient was taken to surgery and found to have NF. A 60-year-old female presented to the emergency department with physical examination findings consistent with severe cellulitis and associated sepsis. A point-of-care ultrasound revealed hyperechoic areas within the soft tissue that were very similar to the prior case. An emergent surgical consultation was placed due to concern for soft-tissue air and NF. However, these hyperechoic areas were found to be subcutaneous calcifications on subsequent imaging. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Air within the soft tissue is easy to identify on point-of-care ultrasound and can expedite surgical evaluation in cases of suspected NF. Calcifications can mimic the appearance of air on ultrasound and the distinction between these objects can often be made based on the echotexture of the posterior acoustic shadow. Attention to the posterior acoustic shadow can facilitate correct identification of various structures and pathologies in a variety of clinical settings. |
[
"O",
"O",
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"I-T038",
"I-T038",
"I-T038",
"O",
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"I-T038",
"O",
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"B-T058",
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"O",
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"O",
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"O",
"O",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T0... | [
{
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{
"db_id": "C0023570",
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{
"db_id": null,
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{
"db_id": "C0234404",
"db_name": "UMLS"
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{
"db_id": "C0234404",
"db_name": "UMLS"
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{
... | [
"Effects",
"of",
"levodopa",
"on",
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"-",
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"learning",
"versus",
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"selection",
"in",
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"has",
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"shown",
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"worsen",
"some",
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"functions",
",",
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[
0,
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32,
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[
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[
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8... | Effects of levodopa on stimulus-response learning versus response selection in healthy young adults Dopaminergic therapy has been shown to worsen some cognitive functions, particularly learning, in Parkinson's disease (PD). This has been attributed to dopamine overdose of brain regions that are relatively dopamine replete. Dopamine dosages are titrated to the severely depleted dorsal striatum (DS). According to this account, dopaminergic therapy should worsen cognitive functions in healthy young adults who have normal dopamine levels. As a critical test of the dopamine overdose hypothesis, we tested the effect of levodopa on learning stimulus-response associations and on performing stimulus-specific responses once these associations were learned. In a randomized, double-blind, placebo-controlled, between-subjects design, 40 healthy young adults completed a stimulus-response learning task on either levodopa or placebo. Half of the participants received 100mg of levodopa and 25mg of carbidopa whereas the other half received an equal volume of placebo. In Session 1, participants learned to associate abstract images with specific key-press responses through trial and error with outcome feedback. In Session 2, participants performed stimulus-specific selections to abstract images they had previously learned in Session 1. Participants treated with levodopa compared to those on placebo demonstrated unambiguously less efficient acquisition of stimulus-response associations. The groups did not differ in their ability to enact stimulus-specific selections once they were learned, however, even though these responses were not overlearned. This pattern of findings is entirely consistent with the effect of levodopa on cognition in PD. The deleterious effects of levodopa on learning seem independent of PD pathology. These results have important implications for understanding mechanisms of cognitive dysfunction in PD and caution about the potential for cognitive deficits in patients treated with levodopa for other indications. |
[
"B-T082",
"O",
"B-T082",
"B-T033",
"I-T033",
"O",
"O",
"B-T017",
"B-T058",
"O",
"O",
"B-T033",
"I-T033",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"B-T098",
"O",
"B-T038"... | [
{
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{
"db_id": null,
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},
{
"db_id": "C3887615",
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{
"db_id": "C0427096",
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},
{
"db_id": "C0427096",
"db_name": "UMLS"
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{
"db_id": null,
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}... | [
"Asymmetry",
"of",
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"movement",
"patterns",
"during",
"active",
"hip",
"abduction",
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"a",
"risk",
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"-",
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"paradigm",
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"... | [
[
0,
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10,
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[
13,
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[
25,
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34,
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43,
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[
50,
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[
57,
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70
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[
71,
73
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[
74,
75
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[
76,
80
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[
81,
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... | Asymmetry of lumbopelvic movement patterns during active hip abduction is a risk factor for low back pain development during standing An induced-pain paradigm has been used in back - healthy people to understand risk factors for developing low back pain (LBP) during prolonged standing. We examined asymmetry of lumbopelvic movement timing during a clinical test of active hip abduction in back-healthy people who developed LBP symptoms during standing (Pain Developers; PDs) compared to back-healthy people who did not develop LBP symptoms during standing (Non Pain Developers, NPDs). Participants completed the hip abduction test while movement was recorded with a motion capture system. Difference in time between start of hip and lumbopelvic movement was calculated (startdiff). PDs moved the lumbopelvic region earlier during left hip abduction than right hip abduction. There was no difference between sides in NPDs. In PDs, the amount of asymmetry was related to average symptom intensity during standing. Asymmetric lumbopelvic movement patterns may be a risk factor for LBP development during prolonged standing. |
[
"B-T033",
"I-T033",
"O",
"B-T033",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"B-T033",
"O",
"O",
... | [
{
"db_id": "C0424000",
"db_name": "UMLS"
},
{
"db_id": "C0424000",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": "C1760428",
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1548428",
"db_name": "UMLS"
}... | [
"Suicidal",
"thoughts",
"and",
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"in",
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"children",
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[
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18,
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[
22,
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[
32,
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35,
50
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[
51,
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[
60,
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[
66,
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],
[
75,
82
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[
83,
92
],
[
93,
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[
103,
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... | Suicidal thoughts and behaviors in psychiatrically referred young children Despite increased awareness of the prevalence and seriousness of mental health problems in early childhood, there have been few empirical studies of suicidal thoughts and behaviors in this age group. This study examined suicidal thoughts and behaviors in 360 preschool-aged children (ages 3 to 7 years) presenting to a psychiatric day treatment program. A semi-structured diagnostic interview (conducted with primary caregivers) was used to assess for child suicidal thoughts and behaviors and psychiatric disorders. Participating mothers also reported on their own psychological distress and family psychiatric history. Forty-eight children (13%) were reported to have suicidal thoughts and behaviors, with suicidal plans or attempts endorsed for 2-3% of the sample. Suicidal thinking and behavior was associated with older child age and with higher rates of concurrent depression, oppositional defiant disorder, and posttraumatic stress disorder in univariate analyses, with age and depression remaining as significant predictors in a multivariate logistic regression model. Findings suggest that suicidal thoughts and behaviors are a significant clinical concern for young children presenting with early psychopathology, particularly depression, with implications for early childhood psychiatric assessment and treatment. |
[
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T038",
"B-T038",
"B-T038",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T038",
"O",
... | [
{
"db_id": null,
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{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
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{
"db_id": "C1833334",
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{
"db_id": "C1833334",
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{
"db_id... | [
"Some",
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"onset",
"postpartum",
"psychosis",
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",",
"each",
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[
0,
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19,
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34,
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45,
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55,
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58,
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[
67,
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[
70,
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[
78,
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8... | Some unusual forms of early onset postpartum psychosis In addition to bipolar cycloid episodes, infective delirium and eclamptic psychosis, each of which has characteristic clinical features and course, brief episodes of delirium and stupor are also seen in the immediate aftermath of parturition. Several mothers have had similar episodes developing later in the first 10 days, and some have cyclical disorders with an unusual time base. Bipolar / cycloid disorders can start on day 1 or even earlier. |
[
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"B-T103",
"I-T103",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T038",
"O",
"B-T103",
"I-T103",
"O",
"B-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"B-T038",
"I-T038"... | [
{
"db_id": "C0040690",
"db_name": "UMLS"
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{
"db_id": null,
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},
{
"db_id": null,
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},
{
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{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,... | [
"TGFβ",
"Contributes",
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"-",
"inflammatory",
"Effects",
"of",
"Tauroursodeoxycholic",
"Acid",
"on",
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"Model",
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"Neuroinflammation",
"The",
"bile",
"acid",
"conjugate",
"tauroursodeoxycholic",
"acid",
"(",
"TUDCA",
"... | [
[
0,
4
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[
5,
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],
[
17,
19
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[
20,
23
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[
24,
28
],
[
28,
29
],
[
29,
41
],
[
42,
49
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[
50,
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[
53,
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[
74,
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[
79,
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82,
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8... | TGFβ Contributes to the Anti-inflammatory Effects of Tauroursodeoxycholic Acid on an Animal Model of Acute Neuroinflammation The bile acid conjugate tauroursodeoxycholic acid (TUDCA) is a neuroprotective agent in various animal models of neuropathologies. We have previously shown the anti-inflammatory properties of TUDCA in an animal model of acute neuroinflammation. Here, we present a new anti-inflammatory mechanism of TUDCA through the regulation of transforming growth factor β (TGFβ) pathway. The bacterial lipopolysaccharide (LPS) was injected intravenously (iv) on TGFβ reporter mice (Smad-binding element (SBE)/Tk-Luc) to study in their brains the real-time activation profile of the TGFβ pathway in a non-invasive way. The activation of the TGFβ pathway in the brain of SBE/Tk-Luc mice increased 24 h after LPS injection, compared to control animals. This activation peak increased further in mice treated with both LPS and TUDCA than in mice treated with LPS only. The enhanced TGFβ activation in mice treated with LPS and TUDCA correlated with both an increase in TGFβ3 transcript in mouse brain and an increase in TGFβ3 immunoreactivity in microglia / macrophages, endothelial cells, and neurons. Inhibition of the TGFβ receptor with SB431542 drug reverted the effect of TUDCA on microglia / macrophages activation and on TGFβ3 immunoreactivity. Under inflammatory conditions, treatment with TUDCA enhanced further the activation of TGFβ pathway in mouse brain and increased the expression of TGFβ3. Therefore, the induction of TGFβ3 by TUDCA might act as a positive feedback, increasing the initial activation of the TGFβ pathway by the inflammatory stimulus. Our findings provide proof-of-concept that TGFβ contributes to the anti-inflammatory effect of TUDCA under neuroinflammatory conditions. |
[
"B-T017",
"B-T038",
"O",
"B-T038",
"I-T038",
"O",
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"B-T017",
"I-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T017",
"I-T017",
"I-T017",
"B-T058",
"I-T058",
"... | [
{
"db_id": "C0682664",
"db_name": "UMLS"
},
{
"db_id": "C1327622",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1979804",
"db_name": "UMLS"
},
{
"db_id": "C1979804",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
}... | [
"Somatosensory",
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... | [
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... | Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus Noxious cutaneous stimulation increases, whereas innocuous cutaneous stimulation decreases serotonin (5-HT) release in the central nucleus of the amygdala (CeA) in anesthetized rats. In the present study, we investigated the contribution of corticotropin releasing factor (CRF) receptors and gamma-aminobutyric acid (GABA) receptors in the dorsal raphe nucleus (DRN) to those responses. Release of 5-HT in the CeA was monitored by microdialysis before and after 10- min stimulation by pinching or stroking. Increased 5-HT release in the CeA in response to pinching was abolished by CRF2 receptor antagonism in the DRN. Decreased 5-HT release in the CeA in response to stroking was abolished by either CRF1 receptor antagonism or GABAA receptor antagonism in the DRN. These results suggest that opposite responses of 5-HT release in the CeA to noxious versus innocuous stimulation of the skin are due to separate contributions of CRF2, CRF1 and GABAA receptors in the DRN. |
[
"O",
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"O",
"O",
"O",
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6... | Unsafe Disposal of Child Faeces: A Community-based Study in a Rural Block in West Bengal, India A clean India is the responsibility of all Indians. One of the objectives of the Swachh Bharat Abhiyan (Clean India Initiative) is to bring about behavioural changes regarding healthy sanitation practices. While large-scale programs in India have increased latrine coverage, they have to some extent failed to bring behavioural changes ensuring optimal latrine use, including the safe disposal of child faeces, which is a significant source of exposure to faecal pathogens. Hence, this study was done to explore child faeces disposal practices in rural West Bengal and to elicit the determinants of unhygienic faeces disposal. Data collection was done using an interview method among the mothers of 502 under-5 children, following a pre-designed, semi-structured schedule during house-to-house visits in a set of villages in the Hooghly district of West Bengal. The prevalence of unsafe disposal of child faeces was 72.4%, and maternal education, per capita income, and water source were found to be significantly associated with unsafe child faeces disposal. This study draws attention to the unsafe disposal of child faeces in this area of India and raises questions about the efficiency of sanitation campaigns in rural India that focus on expanding coverage rather than emphasizing behavioural changes, which are crucial to ensure the safe disposal of child faeces. Thus, it is urgently necessary to strengthen efforts focusing on behavioural changes regarding the safe disposal of child faeces in order to minimise adverse health outcomes. |
[
"O",
"O",
"O",
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"O",
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"O",
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"O",
"O",
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"db_id... | [
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7... | The course of cognitive functioning after first-episode of psychosis: A six month follow-up study Our aim with the present study was to evaluate rank-order and mean-level cognitive functioning stability among first-episode psychosis (FEP) patients, measured using the Cambridge Neuropsychological Test Automated Battery (CANTAB), over a six month period. We also aimed to examine longitudinal measurement invariance and identify factors-such as age, gender, educational level, treatment and psychopathological change scores -potentially linked to cognitive change among patients. In addition, correlations between objectively measured and subjectively evaluated cognitive functioning were estimated. Neuropsychological assessments were administered to 85 patients after the initial stabilisation of their psychosis; 82 of the patients were retested. Subjectively perceived cognitive functioning was measured using a subscale derived from the Estonian version of the Subjective Well-Being Under Neuroleptic Scale (SWN-K-E). On average, executive functioning and processing speed improved significantly, while memory test scores decreased significantly, over time. Very high rank-order stability (r=0.80 to 0.94, p<0.001) was observed with all measured ability scores. Confirmatory factor analysis revealed the loadings of a single (broad ability) factor model were equal across both measurement occasions, but the lack of intercept invariance suggested that mean -level comparisons are more appropriately carried out at a subtest level. On average psychopathology scores and antipsychotics doses declined over time, with the latter also significantly correlating with better executive functioning. Gender was a significant moderator of some domains of cognitive performance, and decline tended to be somewhat more pronounced for women. The results also indicated the lack of any relationship between objective and subjective measurements of cognitive functioning. |
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"I-T058",
"O",
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"I-T062",
"O",
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"Targeting",
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... | Targeting postprandial blood sugar over fasting blood sugar: A clinic based comparative study Recent studies indicate that modulation of post prandial blood sugar (PPBS) plays an important role in the long term glycemic control. Measurement of PPBS is more convenient for patients attending outpatient clinics than fasting blood sugar (FBS) as the former needs only two hours of fasting from the last meal. To assess the value of PPBS monitoring in optimization of long term glycemic control among diabetic patients attending an outpatient clinic. A total of 240 patients with type 2 diabetes (T2DM) attending an out-patient medical clinic were randomized to either PPBS or FBS monitoring. Those who selected to PPBS - group underwent blood sugar measurement 2-h after last meal on the day of their clinic visits and those in the FBS group underwent blood sugar measurement after fasting overnight (8-10h) in the morning of their clinic visits. Treating team was asked to optimize the anti-diabetic medications based on the available PPBS or FBS results. All patients were followed up monthly for six months. Glycemic control was assessed with glycosylated hemoglobin (HbA1c) at baseline and six months later. Baseline characteristics of the two arms including age, gender, and duration of T2DM were not significantly different. Mean HbA1c (SD) of FBS and PPBS arms at baseline were 7.20 (0.45), and 7.33 (0.43) and were not significantly different (P=0.115). During the study period, HbA1c dropped by 0.20 in FBS arm compared to 0.25 drop in PPBS arm (p=0.59). Incidence of hypoglycemia was similar in FBS (2.42%) and PPBS arms (2.70%). Monitoring of PPBS is a safe and effective alternative to FBS to optimize glycemic control in managing patients with T2DM attending outpatient clinics. |
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"B-T058",
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"I-T007",
"O",
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"I-T038",
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"O",
"O",
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{
"db_id": "C0317713",
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"Transcriptomic",
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... | Transcriptomic and Proteomic Analysis of Oenococcus oeni Adaptation to Wine Stress Conditions Oenococcus oeni, the main lactic acid bacteria responsible for malolactic fermentation in wine, has to adapt to stressful conditions, such as low pH and high ethanol content. In this study, the changes in the transcriptome and the proteome of O. oeni PSU-1 during the adaptation period before MLF start have been studied. DNA microarrays were used for the transcriptomic analysis and two complementary proteomic techniques, 2-D DIGE and iTRAQ labeling were used to analyze the proteomic response. One of the most influenced functions in PSU-1 due to inoculation into wine-like medium (WLM) was translation, showing the over-expression of certain ribosomal genes and the corresponding proteins. Amino acid metabolism and transport was also altered and several peptidases were up regulated both at gene and protein level. Certain proteins involved in glutamine and glutamate metabolism showed an increased abundance revealing the key role of nitrogen uptake under stressful conditions. A strong transcriptional inhibition of carbohydrate metabolism related genes was observed. On the other hand, the transcriptional up-regulation of malate transport and citrate consumption was indicative of the use of L-malate and citrate associated to stress response and as an alternative energy source to sugar metabolism. Regarding the stress mechanisms, our results support the relevance of the thioredoxin and glutathione systems in the adaptation of O. oeni to wine related stress. Genes and proteins related to cell wall showed also significant changes indicating the relevance of the cell envelop as protective barrier to environmental stress. The differences found between transcriptomic and proteomic data suggested the relevance of post-transcriptional mechanisms and the complexity of the stress response in O. oeni adaptation. Further research should deepen into the metabolisms mostly altered due to wine conditions to elucidate the role of each mechanism in the O. oeni ability to develop MLF. |
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7... | The Arabidopsis NMD Factor UPF3 Is Feedback-Regulated at Multiple Levels and Plays a Role in Plant Response to Salt Stress Nonsense-mediated mRNA decay (NMD) is a eukaryotic RNA surveillance mechanism that degrades aberrant transcripts and controls the levels of many normal mRNAs. It was shown that balanced expression of the NMD factor UPF3 is essential for the maintenance of proper NMD homeostasis in Arabidopsis. UPF3 expression is controlled by a negative feedback loop that exposes UPF3 transcript to NMD. It was shown that the long 3' untranslated region (3' UTR) of UPF3 exposes its transcript to NMD. Long 3' UTRs that subject their transcripts to NMD were identified in several eukaryotic NMD factors. Interestingly, we show here that a construct that contains all the regulatory regions of the UPF3 gene except this long 3' UTR is also feedback-regulated by NMD. This indicates that UPF3 expression is feedback-regulated at multiple levels. UPF3 is constitutively expressed in different plant tissue s, and its expression is equal in leaves of plants of different ages. This finding is in agreement with the possibility that UPF3 is ubiquitously operative in the Arabidopsis NMD pathway. Expression mediated by the regulatory regions of UPF3 is significantly induced by salt stress. We found that both a deficiency and a strong excess of UPF3 expression are detrimental to plant resistance to salt stress. This indicates that UPF3 plays a role in plant response to salt stress, and that balanced expression of the UPF3 gene is essential for coping with this stress. |
[
"O",
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"O",
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"O",
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... | [
"Navigating",
"through",
"apertures",
":",
"perceptual",
"judgements",
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... | Navigating through apertures: perceptual judgements and actions of children with Developmental Coordination Disorder Passing through a narrow gap / aperture involves a perceptual judgement regarding the size of the gap and an action to pass through. Children with DCD are known to have difficulties with perceptual judgements in near space but whether this extends to far space is unknown. Furthermore, in a recent study it was found that adults with DCD do not scale movements when walking through an aperture in the same way as their peers. The current study, therefore, considered perceptual judgements and motor behaviour of children with DCD while looking at or walking through apertures. Twenty-nine children with DCD and 29 typically developing (TD) children took part. In Experiment 1, participants completed a perceptual task, where they made passability judgements. Children with DCD showed a significantly smaller critical ratio (aperture size at which a participant first rotates the shoulders to pass through) compared to their TD peers. In Experiment 2, participants completed an action task where they walked through the same apertures. Children with DCD showed a significantly larger critical ratio than TD peers when body size alone was accounted for. Taken together these results suggest that perception within a static context is different from that within a dynamic context for children with DCD. However, despite this difference we have demonstrated a clear relationship between perception and action in children with DCD. A video abstract of this article can be viewed at: https://youtu.be/SABXFrAJtF8. |
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7... | Sleep Quantity and Quality during Acute Concussion: A Pilot Study A number of subjective and objective studies provide compelling evidence of chronic post-concussion changes in sleep, yet very little is known about the acute effects of concussion on sleep quality and quantity. Therefore, the purpose of this prospective pilot study was to use actigraphy to examine the changes in sleep quality and quantity acutely following concussion at home rather than in a hospital or sleep laboratory. Seventeen young adults (7 with acute concussion, 10 controls) were recruited for this study. All participants completed two 5- day testing sessions separated by 30 days from intake (controls) or day of injury (concussion). Participants wore actigraphs and kept a sleep journal. Sleep parameter outcomes included nighttime total sleep time (nTST), 24- h total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE). The coefficient of variation (CV) for each sleep parameter was computed for each session. nTST and TST CV was significantly greater in the concussion group. There is the additional indication that individuals with a concussion may require and obtain more sleep shortly after injury and subsequently have a shorter duration of sleep at 1 mo post-injury. This pattern was not seen in the measures of sleep quality (WASO, SE). Individuals with a concussion demonstrated increased nighttime sleep duration variability. This increase persisted at 1 mo post-injury and may be associated with previously documented self-reports of poor sleep quality lasting months and years after a concussion. Additionally, this increase may predispose individuals to numerous negative health outcomes if left untreated. |
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"... | [
{
"db_id": "C0007222",
"db_name": "UMLS"
},
{
"db_id": "C0007222",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Cardiovascular",
"diseases",
"related",
"to",
"ionizing",
"radiation",
":",
"The",
"risk",
"of",
"low",
"-",
"dose",
"exposure",
"(",
"Review",
")",
"Traditionally",
",",
"non",
"-",
"cancer",
"diseases",
"are",
"not",
"considered",
"as",
"health",
"risks",
... | [
[
0,
14
],
[
15,
23
],
[
24,
31
],
[
32,
34
],
[
35,
43
],
[
44,
53
],
[
53,
54
],
[
55,
58
],
[
59,
63
],
[
64,
66
],
[
67,
70
],
[
71,
72
],
[
73,
77
],
[
... | Cardiovascular diseases related to ionizing radiation: The risk of low - dose exposure (Review) Traditionally, non-cancer diseases are not considered as health risks following exposure to low doses of ionizing radiation. Indeed, non-cancer diseases are classified as deterministic tissue reactions, which are characterized by a threshold dose. It is judged that below an absorbed dose of 100 mGy, no clinically relevant tissue damage occurs, forming the basis for the current radiation protection system concerning non-cancer effects. Recent epidemiological findings point, however, to an excess risk of non-cancer diseases following exposure to lower doses of ionizing radiation than was previously thought. The evidence is the most sound for cardiovascular disease (CVD) and cataract. Due to limited statistical power, the dose - risk relationship is undetermined below 0.5 Gy; however, if this relationship proves to be without a threshold, it may have considerable impact on current low ‑ dose health risk estimates. In this review, we describe the CVD risk related to low doses of ionizing radiation, the clinical manifestation and the pathology of radiation-induced CVD, as well as the importance of the endothelium models in CVD research as a way forward to complement the epidemiological data with the underlying biological and molecular mechanisms. |
[
"B-T038",
"O",
"B-T017",
"I-T017",
"I-T017",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T038",
"I-T038",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",
"... | [
{
"db_id": "C0013081",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C2829215",
"db_name": "UMLS"
},
{
"db_id": "C2829215",
"db_name": "UMLS"
},
{
"db_id": "C2829215",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
}... | [
"Downregulation",
"of",
"ZEB2",
"-",
"AS1",
"decreased",
"tumor",
"growth",
"and",
"metastasis",
"in",
"hepatocellular",
"carcinoma",
"Hepatocellular",
"carcinoma",
"(",
"HCC",
")",
"remains",
"one",
"of",
"the",
"most",
"common",
"types",
"of",
"cancer",
"world... | [
[
0,
14
],
[
15,
17
],
[
18,
22
],
[
22,
23
],
[
23,
26
],
[
27,
36
],
[
37,
42
],
[
43,
49
],
[
50,
53
],
[
54,
64
],
[
65,
67
],
[
68,
82
],
[
83,
92
],
[
... | Downregulation of ZEB2-AS1 decreased tumor growth and metastasis in hepatocellular carcinoma Hepatocellular carcinoma (HCC) remains one of the most common types of cancer worldwide and prognosis remains poor. Previous studies have suggested that long non‑coding RNAs (lncRNAs) may be key regulators of tumor development and progression in HCC. It has been determined that 61‑72% of transcribed regions contain lncRNAs in the antisense orientation (aslncRNAs). However, the function of aslncRNAs in HCC remains to be elucidated. The present study investigated the function of the aslncRNA zinc finger E‑box binding homeobox 2 antisense RNA 1 (ZEB2‑AS1) in 40 HCC tissues and 5 different human HCC cell lines using reverse transcription‑quantitative polymerase chain reaction. Additionally, the expression levels of ZEB2‑AS1 were downregulated by transfection of small interfering RNAs (siRNAs) to determine whether ZEB2‑AS1 is capable of affecting cell proliferation, invasion and metastasis by regulating ZEB2, vimentin, fibronectin, E‑cadherin and N‑cadherin expression levels. The results of the present study demonstrated that the expression levels of ZEB2‑AS1 were greater in HCC tissues when compared with the adjacent normal tissues. Furthermore, ZEB2‑AS1 expression was significantly associated with the size of the primary tumor, intrahepatic metastasis and tumor-node-metastasis stage. The Kaplan‑Meier survival curves suggested that patients with high ZEB2‑AS1 expression levels experienced the lowest overall and recurrence‑free survival rates compared with those that had low expression levels. In addition, the current study demonstrated that the downregulation of ZEB2‑AS1 was associated with decreased tumor growth and metastasis in HCC by the regulation of the expression levels of epithelial mesenchymal transition - induced markers. In conclusion, lncRNA ZEB2‑AS1 may be used as a valuable biomarker in patients with HCC. |
[
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T103",
"O",
"B-T103",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"B-T103",
"I-... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0021826",
"db_name": "UMLS"
},
{
"db_id": "C0021826",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Dependence",
"of",
"Intestinal",
"Absorption",
"Profile",
"of",
"Insulin",
"on",
"Carrier",
"Morphology",
"Composed",
"of",
"β",
"-",
"Cyclodextrin",
"-",
"Grafted",
"Chitosan",
"The",
"effect",
"of",
"carrier",
"morphology",
"on",
"the",
"intestinal",
"absorptio... | [
[
0,
10
],
[
11,
13
],
[
14,
24
],
[
25,
35
],
[
36,
43
],
[
44,
46
],
[
47,
54
],
[
55,
57
],
[
58,
65
],
[
66,
76
],
[
77,
85
],
[
86,
88
],
[
89,
90
],
[
... | Dependence of Intestinal Absorption Profile of Insulin on Carrier Morphology Composed of β-Cyclodextrin-Grafted Chitosan The effect of carrier morphology on the intestinal absorption of insulin was investigated using a morphology-tunable polymeric carrier, β-cyclodextrin-grafted chitosan (BCC). The insulin - BCC complexes were prepared in either acetate or citrate buffer solutions, followed by dilution with phosphate buffer for the administration. The complex had a molecular network structure in the acetate buffer, whereas nanoparticles formed in the citrate buffer. The network structure in the acetate buffer was maintained even after dilution with a phosphate buffer, but the nanoparticles in the citrate buffer caused aggregation after dilution. Both complexes enhanced the intestinal absorption of insulin. Interestingly, their absorption profiles were totally different; prompt absorption was observed for the complex prepared in acetate buffer, whereas sustained absorption was observed for the complex prepared in citrate buffer. The difference in the absorption patterns was attributed to the difference in the complex morphology. Next, penetratin, a cell-penetrating peptide, was grafted to BCC to find further improvement in the absorption behavior. A simple mixture of penetratin and BCC was also effective. An oral administration study was also conducted in mice to observe effective suppression of glucose levels, which was further enhanced by coadministration of penetratin. Thus, BCC was proven to be an effective carrier for enhancing oral absorption of peptide drugs, and it is suggested that the carrier morphology is also an important factor that influences the absorption profile. |
[
"O",
"B-T058",
"O",
"B-T062",
"I-T062",
"B-T082",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"B-T017",
"B-T017",
"I-T017",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0041618",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C3640077",
"db_name": "UMLS"
},
{
"db_id": "C3640077",
"db_name": "UMLS"
},
{
"db_id": "C0449445",
"db_name": "UMLS"
}... | [
"Combined",
"ultrasound",
"and",
"exome",
"sequencing",
"approach",
"recognizes",
"Opitz",
"G",
"/",
"BBB",
"syndrome",
"in",
"two",
"malformed",
"fetuses",
"Orofacial",
"clefts",
"are",
"the",
"most",
"common",
"congenital",
"craniofacial",
"anomalies",
"and",
"c... | [
[
0,
8
],
[
9,
19
],
[
20,
23
],
[
24,
29
],
[
30,
40
],
[
41,
49
],
[
50,
60
],
[
61,
66
],
[
67,
68
],
[
68,
69
],
[
69,
72
],
[
73,
81
],
[
82,
84
],
[
8... | Combined ultrasound and exome sequencing approach recognizes Opitz G/BBB syndrome in two malformed fetuses Orofacial clefts are the most common congenital craniofacial anomalies and can occur as an isolated defect or be associated with other anomalies such as posterior fossa anomalies as a part of several genetic syndromes. We report two consecutive voluntary pregnancy interruptions in a nonconsanguineous couple following the fetal ultrasound finding of cleft lip and palate and posterior fossa anomalies confirmed by means of post-termination examination on the second fetus. The quantitative fluorescent PCR, the karyotype, and the comparative genomic hybridization-array analysis after amniocentesis were normal. Exome sequencing on abortive material from both fetuses detected a missense mutation in MID1, resulting in a clinical diagnosis of Opitz G/BBB syndrome. The same mutation was found in the mother and in her brother, who both revealed cerebellar anomalies at an MRI examination. Our study supports the efficacy of exome sequencing in the presence of both a family history suggestive of an inherited disorder and well-documented ultrasound findings. It reveals the importance of a synergistic effort between gynecologists and geneticists aimed at the integration of the most sophisticated ultrasound techniques with the next-generation sequencing tools to provide a definite diagnosis essential to orient the final decision and to estimate a proper recurrence risk. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"B-T037",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"O... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"Daily",
"Use",
"of",
"a",
"Facial",
"Broad",
"Spectrum",
"Sunscreen",
"Over",
"One",
"-",
"Year",
"Significantly",
"Improves",
"Clinical",
"Evaluation",
"of",
"Photoaging",
"Sunscreens",
"are",
"known",
"to",
"protect",
"from",
"sun",
"damage",
";",
"however",
... | [
[
0,
5
],
[
6,
9
],
[
10,
12
],
[
13,
14
],
[
15,
21
],
[
22,
27
],
[
28,
36
],
[
37,
46
],
[
47,
51
],
[
52,
55
],
[
55,
56
],
[
57,
61
],
[
62,
75
],
[
76... | Daily Use of a Facial Broad Spectrum Sunscreen Over One- Year Significantly Improves Clinical Evaluation of Photoaging Sunscreens are known to protect from sun damage; however, their effects on the reversal of photodamage have been minimally investigated. The aim of the prospective study was to evaluate the efficacy of a facial sun protection factor (SPF) 30 formulation for the improvement of photodamage during a 1- year use. Thirty-two subjects applied a broad spectrum photostable sunscreen (SPF 30) for 52 weeks to the entire face. Assessments were conducted through dermatologist evaluations and subjects ' self-assessment at baseline and then at Weeks 12, 24, 36, and 52. Clinical evaluations showed that all photoaging parameters improved significantly from baseline as early as Week 12 and the amelioration continued until Week 52. Skin texture, clarity, and mottled and discrete pigmentation were the most improved parameters by the end of the study (40% to 52% improvement from baseline), with 100% of subjects showing improvement in skin clarity and texture. The daily use of a facial broad-spectrum photostable sunscreen may visibly reverse the signs of existing photodamage, in addition to preventing additional sun damage. |
[
"B-T058",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"B-T170",
"I-T170",
"O",
"B-T170",
"I-T170",
"I-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"B-T103",
"I-... | [
{
"db_id": "C0021440",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0024480",
"db_name": "UMLS"
},
{
"db_id": "C0024480",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Intravenous",
"and",
"Nebulized",
"Magnesium",
"Sulfate",
"for",
"Treating",
"Acute",
"Asthma",
"in",
"Children",
":",
"A",
"Systematic",
"Review",
"and",
"Meta",
"-",
"Analysis",
"This",
"study",
"aimed",
"to",
"evaluate",
"the",
"efficacy",
"of",
"intravenous... | [
[
0,
11
],
[
12,
15
],
[
16,
25
],
[
26,
35
],
[
36,
43
],
[
44,
47
],
[
48,
56
],
[
57,
62
],
[
63,
69
],
[
70,
72
],
[
73,
81
],
[
81,
82
],
[
83,
84
],
[
... | Intravenous and Nebulized Magnesium Sulfate for Treating Acute Asthma in Children: A Systematic Review and Meta-Analysis This study aimed to evaluate the efficacy of intravenous (IV) and nebulized magnesium sulfate in acute asthma in children. The PubMed, Cochrane Library, and EMBASE databases were searched. Randomized controlled trials and quasi-randomized controlled trials of IV and nebulized magnesium sulfate in pediatric acute asthma were included. The outcomes subject to meta-analysis were pulmonary function, hospitalization, and further treatment. If statistical heterogeneity was significant, random-effects models were used for meta-analysis, otherwise, fixed-effects models were applied. Ten randomized and quasi-randomized trials (6 IV, 4 nebulized) were identified. Intravenous magnesium sulfate treatment is associated with significant effects on respiratory function (standardized mean difference, 1.94; 95% confidence interval [CI], 0.80-3.08; P = 0.0008) and hospital admission (risk ratio, 0.55; 95% CI, 0.31-0.95; P = 0.03). But nebulized magnesium sulfate treatment shows no significant effect on respiratory function (standardized mean difference, 0.19; 95% CI, -0.01-0.40; P = 0.07) or hospital admission (risk ratio, 1.11; 95% CI, 0.86-1.44; P = 0.42). The meta-analysis revealed that IV magnesium sulfate is an effective treatment in children, with the pulmonary function significantly improved and hospitalization and further treatment decreased. But nebulized magnesium sulfate treatment showed no significant effect on respiratory function or hospital admission and further treatment. |
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