Unnamed: 0 int64 0 10k | Cancer Type stringclasses 10
values | PMID int64 20.3M 39.6M | Title stringlengths 1 514 ⌀ | Abstract stringlengths 1 10k ⌀ |
|---|---|---|---|---|
0 | bone cancer | 39,614,431 | Signal Transduction Mechanisms of Focal Adhesions: Src and FAK-Mediated Cell Response. | Cell-to-substrate adhesion sites, also known as focal adhesion sites (FAs), are complexes of different proteins on the cell surface. FAs play important roles in communication between cells and the extracellular matrix (ECM), leading to signal transduction involving different proteins that ultimately produce the cell re... |
1 | bone cancer | 39,614,373 | Clinical efficacy on the reconstruction of bone defects using modular hemipelvic prosthesis in patients with pelvic tumors. | To evaluate the clinical efficacy of modular hemipelvic prosthesis replacement in the treatment of pelvic tumors and the relationship between postoperative functional recovery and the position deviation of the hip rotation center. |
2 | bone cancer | 39,614,338 | Gremlin-2 is a novel tumor suppressor that negatively regulates ID1 in breast cancer. | Breast cancer is one of the most common cancers in women and is closely associated with obesity. Gremlin-2 (GREM2), an antagonist for bone morphogenetic proteins (BMPs), has been considered an inhibitor of adipogenic differentiation in adipose-derived stromal/stem cells. However, the role of GREM2 in breast cancer cell... |
3 | bone cancer | 39,614,304 | Complete resection of a giant costal chondrosarcoma with reconstruction of the thoraco-abdominal wall: a case report. | Chondrosarcoma primarily occurs in the pelvis and femur, with occasional cases in the ribs. Surgical resection remains the main treatment method for costal chondrosarcoma. However, complete resection often leads to a large range of chest wall defects and a challenging reconstruction. |
4 | bone cancer | 39,613,747 | Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy. | The long-term consequences of cancer and its therapy on the patients' immune system years after cancer-free survival remain poorly understood. Here, we present an in-depth characterization of the bone marrow immune ecosystem of multiple myeloma long-term survivors, from initial diagnosis up to 17 years following a sing... |
5 | bone cancer | 39,613,566 | Baseline Nodal Status on | There is uncertainty regarding the clinical significance of |
6 | bone cancer | 39,613,437 | Protocol for a multicentric, double-blind, randomised controlled trial of hyperbaric oxygen therapy (HBOT) versus sham for treating vaso-occlusive crisis (VOC) in sickle cell disease (SCD) in patients aged 8 years or older (HBOT-SCD study). | Sickle cell disease (SCD) is one of the most common genetic diseases in the world, annually affecting approximately 310 000 births and causing >100 000 deaths. Vaso-occlusive crisis (VOC) is the most frequent complication of SCD, leading to bone pain, thoracic pain (acute chest syndrome) and/or abdominal spasms. It is ... |
7 | bone cancer | 39,613,360 | [Preventive activities in women: PAPPS 2024 update]. | In the 2024 PAPPS update, we present preventive activities specific to women's health, except those related to cancer prevention (which are included in another document) and aspects related to differential morbidity of gender, which is a cross-cutting element for all working groups. Contraception is an essential preven... |
8 | bone cancer | 39,613,336 | Autologous stem cell transplantation for multiple myeloma patients whose myeloma-defining event was SLiM. | In 2014, the International Myeloma Working Group (IMWG) updated the criteria for diagnosing myeloma and added three additional criteria to the traditional Calcium elevation, Renal impairment, Anemia, Bone disease (CRAB) criteria, called the Sixty % marrow plama cells, Light chain ratio >60, Mri demonstates lytic lesion... |
9 | bone cancer | 39,612,644 | Disruption of distal appendage protein CEP164 causes skeletal malformation in mice. | The primary cilium is a cellular antenna to orchestrate cell growth and differentiation. Deficient or dysfunctional cilia are frequently linked to skeletal abnormalities. Previous research demonstrated that ciliary proteins regulating axoneme elongation are essential for skeletogenesis. However, the role of the ciliary... |
10 | bone cancer | 39,614,111 | Integrative mapping of human CD8 | CD8 |
11 | bone cancer | 39,613,415 | Remission of longstanding metastatic paraganglioma in a patient after use of zoledronic acid. | A patient with a long history of bone predominant, metastatic paraganglioma who had multiple episodes of progressive disease despite prior treatments demonstrated a remarkable disease response to zoledronic acid. After 1 year of treatment, there was a complete resolution of lymphadenopathy and disappearance of all soma... |
12 | bone cancer | 39,613,124 | Compound-dependent fetal toxicity after in utero exposure to chemotherapy in a pregnant mouse model. | Although chemotherapy is integrated in the treatment of second-trimester pregnant cancer patients, its potential cyto- and genotoxicity to fetal tissue remains unknown. To investigate any causal relation between in utero chemotherapy exposure and fetal toxicity, late-gestation pregnant BL6 mice were exposed to vehicle,... |
13 | bone cancer | 39,612,446 | Talus osteoid osteoma misdiagnosed as ankle synovitis: A case report in rehabilitation therapy. | Osteoid osteoma, accounting for approximately 10% of benign bone tumors, is predominantly found in long bones and rarely in the foot bones, such as the talus. Its nonspecific symptoms, such as nocturnal pain and swelling, often lead to misdiagnosis, especially when it mimics conditions like ankle synovitis. |
14 | bone cancer | 39,612,415 | Development of a nomogram for predicting cancer pain in lung cancer patients: An observational study. | During the progression of lung cancer, cancer pain is a common complication. Currently, there are no accurate tools or methods to predict the occurrence of cancer pain in lung cancer. Our study aims to construct a predictive model for lung cancer pain to assist in the early diagnosis of cancer pain and improve prognosi... |
15 | bone cancer | 39,612,007 | The effect and mechanism of IL-37d on neutrophil recruitment in the early stage of tumor metastasis in the lungs. | Chronic inflammation plays a pivotal role in cancer progression, with tumor-associated neutrophils (TANs) actively shaping the pre-metastatic niche. Interleukin-37 (IL-37), a known immunosuppressive cytokine, is implicated in this regulation, although its precise function remains underexplored.Therefore, this study see... |
16 | bone cancer | 39,611,806 | Evaluation and comparison of synthetic computed tomography algorithms with 3T MRI for prostate radiotherapy: AI-based versus bulk density method. | Synthetic computed tomography (sCT)-algorithms, which generate computed tomography images from magnetic resonance imaging data, are becoming part of the clinical radiotherapy workflow. The aim of this retrospective study was to evaluate and compare commercial bulk-density-method (BM)-based and AI (artificial intelligen... |
17 | bone cancer | 39,611,766 | Enhancing targeted doses: Low-energy photon lipiodol-enhanced radiotherapy (LEPERT) for liver cancer patients. | This study proposes a novel approach, "Low-energy photon Lipiodol-Enhanced Radiotherapy" (LEPERT), for patients with liver cancer. Moreover, we evaluate the dose difference of the conventional treatment planning with 10 MV X-ray beam (MV-plan) and LEPERT. |
18 | bone cancer | 39,611,637 | BONE AND SARCOMAS. | No abstract found |
19 | bone cancer | 39,611,265 | Prostate cancer presenting as an oral swelling-A case report. | Tumour metastasis to the jaw is an uncommon finding. When it does present, it is usually evidence of widespread metastatic disease and represents an unfavourable prognostic indicator. The clinical presentation of metastatic disease in the jaw can vary and may occur in the oral soft tissues, subcutaneous tissues adjacen... |
20 | bone cancer | 39,611,065 | Identification and validation of a novel prognostic model based on anoikis‑related genes in acute myeloid leukemia. | Acute myeloid leukemia (AML) is a hematological cancer prevalent worldwide. Anoikis-related genes (ARGs) are crucial in the progression of cancer and metastasis of tumors. However, their role in AML needs to be clarified. In the present study, differential analysis was performed on data from The Cancer Genome Atlas dat... |
21 | bone cancer | 39,610,013 | Length of Time to Clinical Improvement After Orthopedic Oncology Surgery in Patients With Metastatic Cancer: A Multi-Institution Patient-Reported Outcome Study. | Currently, there is a paucity of data that describes the length of time required to realize improvement in pain and function following surgery for patients with metastatic cancer to bone. |
22 | bone cancer | 39,609,983 | ENDOSCOPIC ENDONASAL TRANS-SPHENOIDAL SURGERY IN PATIENTS WITH MACRO-ADENOMA EXTENT OF SURGICAL RESECTION AND RECURRENCE RATE. | Endoscopic Endonasal Trans-Sphenoidal Approach has been employed for skull base tumours especially macro-adenomas, for the last decade in our setup. Here we are sharing our experience with the EETA for patients with micro-adenomas in terms of extent of tumour resection and its recurrence. The objective was to assess en... |
23 | bone cancer | 39,609,867 | A clinical study of autologous chimeric antigen receptor macrophage targeting mesothelin shows safety in ovarian cancer therapy. | CAR-macrophage has promising prospect in treating solid tumors, due to its high infiltration into tumors, and its dual roles in phagocytosis and immune modulation. Here we show the clinical results of CAR-macrophage treatment of two ovarian cancer patients. The CAR-macrophages were produced by introducing a mesothelin ... |
24 | bone cancer | 39,609,469 | Pericytes require physiological oxygen tension to maintain phenotypic fidelity. | Pericytes function to maintain tissue homeostasis by regulating capillary blood flow and maintaining endothelial barrier function. Pericyte dysfunction is associated with various pathologies and has recently been found to aid cancer progression. Despite having critical functions in health and disease, pericytes remain ... |
25 | bone cancer | 39,609,411 | High level of circulating cell-free tumor DNA at diagnosis correlates with disease spreading and defines multiple myeloma patients with poor prognosis. | Multiple myeloma (MM) is a plasma cell (PC) disorder characterized by skeletal involvement at the time of diagnosis. Recently, cell-free DNA (cfDNA) has been proven to recapitulate the heterogeneity of bone marrow (BM) disease. Our aim was to evaluate the prognostic role of cfDNA at diagnosis according to disease distr... |
26 | bone cancer | 39,608,833 | Painful scoliosis in an adolescent: a diagnostic dilemma. | Osteoid osteoma is a benign bone-forming tumour, seen more frequently in males than females, during the first three decades of their life. It accounts for 3% of all bone neoplasms and 10-12% of benign bone lesions. The spine is involved in approximately 10-20% of cases. A teenage boy presented with complaints of low ba... |
27 | bone cancer | 39,608,805 | Expert consensus recommendations for the diagnosis and treatment of chronic non-bacterial osteitis (CNO) in adults. | There is considerable practice variation in labelling, diagnosis and treatment of adults with sterile bone inflammation. We developed a expert consensus recommendations on the disease definition, diagnosis and treatment of this rare condition. |
28 | bone cancer | 39,608,726 | Osteosarcopenic adiposity and its relation to cancer and chronic diseases: Implications for research to delineate mechanisms and improve clinical outcomes. | This is the third review in our series examining the connection between osteosarcopenic adiposity/obesity (OSA/OSO) syndrome and health impairments. The objective here was to examine whether there is a causal and/or bidirectional relationship between OSA and some chronic diseases. The search (in PubMed, Scopus, and WoS... |
29 | bone cancer | 39,608,521 | Identifying potential active ingredients from pomegranate in treating anemia: CPA3 and SOX4 are key proteins. | Fanconi anemia is a rare hereditary blood disorder that usually manifests as bone marrow failure, dysplasia, cancer susceptibility and anemia. Pomegranate, as a "secret" for people in Xinjiang, China and India, is commonly used for treating different types of anemia. |
30 | bone cancer | 39,608,504 | miRNA signatures affecting the survival outcome in distant metastasis of triple-negative breast cancer. | Triple-negative breast cancer (TNBC) constitutes for 10-15% of all breast cancer cases. Tumor heterogeneity, high invasiveness, distant metastasis, lack of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 expression contribute to TNBC associated with poor overall survival outcome... |
31 | bone cancer | 39,608,480 | COPS5 regulates osteosarcoma progression by upregulating KHSRP to promote Per2 mRNA decay. | Osteosarcoma (OS) is a common bone sarcoma that is often seen in children and adolescents. This study delves into the intricate regulatory network involving COP9 signalosome subunit 5 (COPS5), KH-type splicing regulatory protein (KHSRP), and Period circadian clock 2 (Per2) in the context of osteosarcoma cell malignant ... |
32 | bone cancer | 39,608,466 | N6-(2-hydroxyethyl)-adenosine (HEA) exhibits antitumor activity for osteosarcoma progression by regulating IGF1 signaling. | Osteosarcoma is a highly malignant bone tumor with poor prognosis and limited treatment options due to resistance and side effects. |
33 | bone cancer | 39,608,316 | The additive effect of 17β-estradiol on the modulation of electrochemotherapy with calcium ions or cisplatin in human clear carcinoma cells. | Calcium electroporation (CaEP) is an efficient approach for ovarian cancer treatment. It causes cell death by introducing elevated levels of calcium into cells. In this work, the research focused on two types of cell lines: CHO-K1, representing normal ovary cells, and OvBH-1, representing ovarian clear carcinoma cells.... |
34 | bone cancer | 39,608,007 | Whole-body PET/MRI to detect bone metastases: comparison of the diagnostic performance of the sequences. | Whole-body positron emission tomography/magnetic resonance imaging (WB-PET/MRI) is increasingly used in the initial evaluation of oncology patients. The purpose of this study was to compare the diagnostic performance of WB MRI sequences, attenuation-corrected raw data positron-emission tomography (AC PET), and PET/MRI ... |
35 | bone cancer | 39,607,746 | Comparative Study of [ | null |
36 | bone cancer | 39,607,643 | Aberrant promoter methylation, expression and function of RASSF1A gene in a series of Italian parathyroid tumors. | Aberrant epigenetic features are key events involved in parathyroid tumorigenesis, including DNA methylation, histone methylation, and non-coding RNAs. Ras Association Domain Family Protein1 Isoform A (RASSF1A) and Adenomatous Polyposis of Colon (APC) are frequently downregulated in human cancers. Here, we investigated... |
37 | bone cancer | 39,607,243 | Cardiac Abnormalities in Hypereosinophilic Syndromes. | Hypereosinophilia (HE) is defined as an eosinophil count exceeding 1500 cells/microL in peripheral blood in two tests, performed with an interval of at least one month and/or anatomopathological confirmation of HE, with eosinophils comprising more than 20% of all nucleated cells in the bone marrow. Hypereosinophilic sy... |
38 | bone cancer | 39,606,948 | Vascular endothelial growth factor and programmed cell death-1 inhibition in bone sarcomas. | No abstract found |
39 | bone cancer | 39,606,837 | REGAL: galinpepimut-S vs. best available therapy as maintenance therapy for acute myeloid leukemia in second remission. | Patients with relapsed or refractory (r/r) acute myeloid leukemia (AML) have very poor long-term outcomes. Allogeneic stem cell transplantation (allo-SCT) can potentially cure some of these patients who are able to achieve a second or greater remission with salvage chemotherapy. Unfortunately, several barriers exist to... |
40 | bone cancer | 39,606,739 | A multicenter study to evaluate the analytical precision by pathologists using the Aperio GT 450 DX. | Digital pathology systems (DPS) are emerging as capable technologies for clinical practice. Studies have analyzed pathologists' diagnostic concordance by comparing reviews of whole slide images (WSIs) to glass slides (e.g., accuracy). This observational study evaluated the reproducibility of pathologists' diagnostic re... |
41 | bone cancer | 39,606,566 | Primary breast myeloid sarcoma: A case report and literature review. | Myeloid sarcoma (MS) is a rare extramedullary tumor originating from immature bone marrow cells. MS of the breast is an extremely uncommon disease with non-specific clinical and radiological features. The present case report describes a distinctive case of MS of the breast, which posed diagnostic challenges due to the ... |
42 | bone cancer | 39,606,425 | Orchestrated copper-loaded nanoreactor for simultaneous induction of cuproptosis and immunotherapeutic intervention in colorectal cancer. | Ion interference, including intracellular copper (Cu) overload, disrupts cellular homeostasis, triggers mitochondrial dysfunction, and activates cell-specific death channels, highlighting its significant potential in cancer therapy. Nevertheless, the insufficient intracellular Cu ions transported by existing Cu ionopho... |
43 | bone cancer | 39,606,226 | Preclinical delayed toxicity studies of BCMA CAR T-cell injection in B-NDG mice with multiple myeloma. | Based on the efficacy data from the previous study of B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell injection, we further examined the delayed toxicity for 8 weeks after a single dose of BCMA CAR T-cell injection to observe possible toxic reactions. |
44 | bone cancer | 39,606,160 | The quantitative impact of prostate-specific membrane antigen (PSMA) PET/CT staging in newly diagnosed metastatic prostate cancer and treatment-decision implications. | To quantify the stage-shift with prostate-specific membrane antigen (PSMA) PET/CT imaging in metastatic prostate cancer and explore treatment implications. |
45 | bone cancer | 39,606,014 | Case report: Rethinking NGS analysis in diagnosing Diamond-Blackfan anemia syndrome. | Diamond-Blackfan anemia syndrome (DBAS) is a rare inherited bone marrow failure (BMF) syndrome characterized by erythroid aplasia, congenital malformations, and cancer predisposition. With its genetic heterogeneity, variable penetrance and expressivity, DBAS poses significant diagnostic challenges, necessitating advanc... |
46 | bone cancer | 39,605,980 | Significance of exosomes in osteosarcoma research: a systematic review and meta-analysis of a singular clinical investigation. | Osteosarcoma is the most prevalent among primary bone malignancies, and its standard intervention involves neoadjuvant chemotherapy - surgical adjuvant chemotherapy (MAP regimen) with adriamycin, cisplatin, and high-dose methotrexate. Early-stage osteosarcoma can be effectively treated with surgical resection along wit... |
47 | bone cancer | 39,605,953 | The Role of Delayed Imaging at MRI in Rare Non-enhancing Prostate Cancer Brain Metastases: A Case Report. | Brain metastases in prostate cancer are rare (<2% of cases). In magnetic resonance imaging, nearly all brain metastases exhibit contrast-enhancement, which may be affected by the time elapsed since the administration of the contrast agent. We discuss a case where the brain metastases in a patient with prostate cancer d... |
48 | bone cancer | 39,605,887 | Molecular mechanism of bone metastasis in breast cancer. | Bone metastasis is a debilitating complication that frequently occurs in the advanced stages of breast cancer. However, the underlying molecular and cellular mechanisms of the bone metastasis remain unclear. Here, we elucidate how bone metastasis arises from tumor cells that detach from the primary lesions and infiltra... |
49 | bone cancer | 39,605,631 | Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor survival prognosis. | Collagen type X (ColXα1, encoded by |
50 | bone cancer | 39,605,505 | Neutrophil extracellular traps promote tumor chemoresistance to anthracyclines. | The microenvironment plays an important role in promoting tumor cell chemoresistance, but the mechanisms responsible for this effect are not clear. Here, using models of multiple myeloma (MM) and solid cancers, we demonstrate a novel mechanism mediated by neutrophils, a major cell population in the bone marrow (BM), th... |
51 | bone cancer | 39,605,261 | [Clinical analysis of endoscopic transnasal resection of skull base chondrosarcoma]. | null |
52 | bone cancer | 39,605,211 | Novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma. | Multiple myeloma (MM) is a clonal plasma cell proliferative malignancy characterized by a debilitating bone disease. Osteolytic destruction, a hallmark of MM, is driven by increased osteoclast number and exacerbated bone resorption, primarily fueled by the excessive production of RANKL, the master regulator of osteocla... |
53 | bone cancer | 39,605,207 | Isatuximab, pomalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: the Italian, multicenter, retrospective clinical experience with 270 cases outside of controlled clinical trials. | Not available. |
54 | bone cancer | 39,605,204 | Donor cytomegalovirus serology impacts overall survival in children receiving first unrelated hematopoietic stem cell transplant for acute leukemia: European Society of Bone Marrow Transplantation Pediatric Diseases Working Party Study. | Not available. |
55 | bone cancer | 39,605,194 | Methotrexate Versus Mycophenolate Mofetil Prophylaxis in Allogeneic Hematopoietic Cell Transplantation for Chronic Myeloid Malignancies: A Retrospective Analysis on Behalf of the Chronic Malignancies Working Party of the EBMT. | Prophylaxis strategies for Graft versus host disease (GVHD) in allogeneic hematopoietic cell transplantation (allo-HCT) frequently encompass a combination of a calcineurin inhibitor (CNI) with either methotrexate (MTX) or mycophenolate mofetil (MMF). The aim of this retrospective, EBMT registry-based study was to deter... |
56 | bone cancer | 39,605,126 | Mesenchymal stem cells treated with Interleukin-1 beta for mediation of an inflammatory response in human tissues. | The present study examined the functional activities of the human bone marrow mesenchymal stem cells (hBM-MSCs) under the effects of various concentrations of the inflammatory mediator interleukin 1 beta (IL-1β). The effects of IL-1β on the functional properties of hBM-MSCs were measured using functional assays (adhesi... |
57 | bone cancer | 39,604,942 | Solitary fibrous tumors of the oral and maxillofacial region: a case series from a single-center. | Solitary fibrous tumor (SFT) is a rare mesenchymal lesion that has a wide anatomic distribution. However, this lesion rarely occurs in the oral or maxillofacial region. |
58 | bone cancer | 39,604,763 | TGFβ family signaling in human stem cell self-renewal and differentiation. | Human stem cells are undifferentiated cells with the capacity for self-renewal and differentiation into distinct cell lineages, playing important role in the development and maintenance of diverse tissues and organs. The microenvironment of stem cell provides crucial factors and components that exert significant influe... |
59 | bone cancer | 39,604,762 | Mouse and human macrophages and their roles in cardiovascular health and disease. | The past 15 years have witnessed a leap in understanding the life cycle, gene expression profiles, origins and functions of mouse macrophages in many tissues, including macrophages of the artery wall and heart that have critical roles in cardiovascular health. Here, we review the phenotypical and functional diversity o... |
60 | bone cancer | 39,604,759 | Prognostic impact of preoperative osteosarcopenia on esophageal cancer surgery outcomes: a retrospective analysis. | Osteosarcopenia, recognized as a consequence of aging, has garnered attention as a prognostic marker in recent years; however, its clinical significance in esophageal cancer remains uncertain. This study aimed to investigate the impact of osteosarcopenia on esophageal cancer surgery outcomes. |
61 | bone cancer | 39,604,730 | Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers. | Interleukin-15 (IL-15) promotes the survival of T lymphocytes and enhances the antitumour properties of chimeric antigen receptor (CAR) T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy |
62 | bone cancer | 39,604,650 | Splenic T2 signal intensity loss on MRI is associated with disease burden in multiple myeloma. | This study aims to evaluate correlations between spleen signal changes in different MRI sequences and bone marrow plasma cell infiltration as potential indicator of disease burden in multiple myeloma (MM) patients. |
63 | bone cancer | 39,604,602 | Establishment and characterization of NCC-GCTB14-C1 and NCC-GCTB15-C1: two novel patient-derived cell lines of giant cell tumor of bone. | Giant cell tumor of bone (GCTB) is a rare bone tumor that is genetically characterized by a unique mutation in the H3-3A gene. Curative surgical resection is the standard treatment. Unfortunately, a considerable proportion of patients with GCTB have local recurrence and pulmonary metastasis after surgical treatment, an... |
64 | bone cancer | 39,604,595 | Construction of AML prognostic model with CYP2E1 and GALNT12 biomarkers based on golgi- associated genes. | Acute myeloid leukaemia (AML) was originally an aggressive malignancy of the bone marrow and one of the deadliest forms of acute leukaemia. The 5-year mortality benefit for patients with AML was only 28.3%. Moreover, a large proportion of patients experienced frequent relapses even after remission, thus predicting a bl... |
65 | bone cancer | 39,604,456 | null | This study investigates the utility of |
66 | bone cancer | 39,604,143 | Malignant Bone-Forming Neoplasm With NIPBL::BEND2 Fusion. | Conventional high-grade osteosarcomas are characterized by aggressive radiologic features, cytologic pleomorphism, and complex genomics. However, rare examples of osteosarcomas remain challenging due to unusual histology, such as sclerosing or osteoblastoma-like features, which may require molecular confirmation of the... |
67 | bone cancer | 39,604,137 | Epigenetic Modeling of Jumping Translocations of 1q Heterochromatin in Acute Myeloid Leukemia After 5'-Azacytidine Treatment. | Jumping translocations (JT) are rare cytogenetic abnormalities associated with progression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Typically, a tri-tetra-somic 1q chromosome is translocated to two or more recipient chromosomes. In multiple myeloma JT were shown to originate after DNA demeth... |
68 | bone cancer | 39,604,120 | Investigational drugs in early phase trials for myelofibrosis. | Myelofibrosis (MF) is a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, cytopenias, and organomegaly. Four JAK inhibitors are US-FDA approved for treatment of MF. While these drugs reduce symptom burden and spleen size to varying degrees, they do not affect the natural disease course or decre... |
69 | bone cancer | 39,603,905 | Implications for metabolic disturbances in myelodysplastic syndromes. | The Myelodysplastic Syndromes (MDS) are heterogeneous stem cell malignancies clinically characterized by bone marrow dysplasia, peripheral blood cytopenias, and a high risk for transformation to acute myeloid leukemia. In early stages of disease, differentiation defects and maturation blocks result in deficient hematop... |
70 | bone cancer | 39,603,902 | Real-World Outcomes of Pyrotinib-Based Therapy for HER2-Positive Breast Cancer With Brain Metastases: A Multicentre, Retrospective Analysis. | This study was designed to investigate the efficacy and safety of pyrotinib-based therapy for HER2-positive breast cancer with brain metastases (BM) in the real-world setting. |
71 | bone cancer | 39,603,682 | Plasmablastic multiple myeloma presenting as a pleural mass: a diagnostic challenge. | Plasmablastic multiple myeloma (MM) is a rare and highly aggressive variant of MM that presents significant diagnostic and therapeutic challenges. This variant is characterised by a bone marrow infiltration of ≥2% plasmablasts and is distinguished by its atypical pleomorphic morphology, unique immunohistological profil... |
72 | bone cancer | 39,603,540 | pH-responsive hydrogel with gambogic acid and calcium nanowires for promoting mitochondrial apoptosis in osteosarcoma. | Calcium (Ca |
73 | bone cancer | 39,603,396 | Kaempferol modulates ɑ2M secretion in bone marrow-derived macrophages by downregulating GR/PER1-mediated lipid metabolism to attenuate the emotional stress-aggravated metastasis of prostate cancer. | Prostate cancer patients often suffer from depression during androgen deprivation therapy. Chaihu-Shugan-San (CSS) can prevent prostate cancer metastasis caused by chronic unpredictable mild stress (CUMS), but its active ingredients and molecular mechanism remain unelucidated. |
74 | bone cancer | 39,603,206 | Niraparib perturbs autophagosome-lysosome fusion in pancreatic ductal adenocarcinoma and exhibits anticancer potential against gemcitabine-resistant PDAC. | While poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPi) have achieved specific clinical benefits in a subset of pancreatic ductal adenocarcinoma (PDAC) patients, the potential role of the PARPi niraparib in PDAC necessitates further exploration. In this study, we demonstrated that Niraparib exhibited a ... |
75 | bone cancer | 39,603,004 | Monte Carlo study of organ doses and related secondary cancer risk estimations for patients undergoing prostate radiotherapy: Algerian population-based study. | The present study aimed to assess organ doses and the associated cancer risks related to secondary radiation (photons and neutrons) exposure during 3D Conformational Radiotherapy (3D-CRT) for patients with prostate cancer in Algeria. To this purpose, a detailed geometric Monte Carlo (MC) modeling of the LINAC, combined... |
76 | bone cancer | 39,602,960 | Polyphyllin VI: A promising treatment for prostate cancer bone metastasis. | Prostate cancer, as one of the most prevalent malignant tumors in men, seriously affects the prognosis and survival of patients due to its extremely high rate of bone metastasis. This study investigated the effect of Polyphyllin VI (PPVI) on metastatic bone disease for the first time in prostate cancer, focusing on its... |
77 | bone cancer | 39,602,939 | Extensive humerus and scapula hydatidosis: A unique case report and comprehensive review of management strategies. | Bone hydatidosis is a rare manifestation of Echinococcus infection, presenting significant diagnostic and therapeutic challenges. This case report describes the successful management of an extensive hydatid disease involving the entire humerus and scapula. |
78 | bone cancer | 39,602,849 | Difference in efficacy of osimertinib between patients with EGFR-positive NSCLC with postoperative recurrence and those with de novo unresectable disease: A prospective, observational study. | Although clinical trials of systemic chemotherapy for advanced non-small-cell lung cancer (NSCLC) have included both postoperative recurrence and de novo unresectable cases, postoperative recurrence is reported to have a better efficacy and prognosis. However, there are no efficacy data of first-line osimertinib for po... |
79 | bone cancer | 39,602,390 | Dose-Related Mutagenic and Clastogenic Effects of Benzo[ | Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that originate from the incomplete combustion of organic materials. We investigated the clastogenicity and mutagenicity of benzo[ |
80 | bone cancer | 39,602,341 | Clinical impact of [18F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma. | Multiple myeloma (MM) remains incurable, with poor outcomes in heavily pre-treated patients with plasmacytomas. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising treatment option; however, outcomes after such therapy in patients with soft-tissue plasmacytomas and other bone lesions remain poorly... |
81 | bone cancer | 39,602,148 | Model-based dosing for better survival after transplantation. | No abstract found |
82 | bone cancer | 39,601,780 | Update on cancer screening in children with syndromes of bone lesions, hereditary leiomyoma and renal cell carcinoma syndrome, and other rare syndromes. | The management of children with syndromes associated with an increased risk of benign and malignant neoplasms is a complex challenge for healthcare professionals. The 2023 AACR Childhood Cancer Predisposition Workshop provided updated consensus guidelines on cancer surveillance in these syndromes, aiming to improve ear... |
83 | bone cancer | 39,601,653 | [Survival after hematopoietic stem cell transplantation with identical and haploidentical donors]. | Allogeneic hematopoietic stem cell transplantation (HSCT) is a therapy that offers the potential to cure hematological malignancies. One limitation is that only 25% of patients will have an identical donor. The use of haploidentical donors allows 95% of patients to have a donor. Experience in Mexico with haploidentical... |
84 | bone cancer | 39,601,563 | Preparing Nurses for CD20-CD3 Bispecific Antibody Treatment in Patients With Non-Hodgkin Lymphoma: A Scoping Review of Adverse Events and Management Strategies From Early Phase and Pivotal Trials. | Bispecific T-cell engaging antibodies (BsAbs) are novel agents used to treat B-cell non-Hodgkin lymphoma (B-NHL); these agents demonstrate a different toxicity profile compared with standard chemoimmunotherapy. |
85 | bone cancer | 39,601,341 | The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells. | Multiple myeloma (MM) is a haematological malignancy with abnormal proliferation of plasma cells in the bone marrow (BM), and MM patients with highly proliferative plasma cells have reduced overall survival. Circular RNAs (circRNAs) are endogenous, non-coding molecules that are promising biomarkers in cancer. Here, we ... |
86 | bone cancer | 39,601,315 | Spectrum of Craniofacial and Oral Malformations in China, a Multicenter Study. | Craniofacial and oral malformations (COMs) represent an important class of human developmental disorders with profound implications on the anatomical structure, appearance, and various physiological functions. In this study, we aimed to define the spectrum of COMs and analysis its features or possible influencing facto... |
87 | bone cancer | 39,601,252 | Prognostic Factors Associated With Increased Mortality in Pediatric Veno-Occlusive Disease Following Hematopoietic Cell Transplantation. | Hepatic veno-occlusive disease (VOD) is a life-threatening complication of hematopoietic cell transplantation (HCT) and is categorized as a transplant-related, systemic endothelial disease. Severe VOD can lead to multi-organ dysfunction (MOF) and is associated with a high mortality rate. |
88 | bone cancer | 39,601,093 | Incidental Ovarian Uptake in Bone Scintigraphy. | A 47-year-old woman, recently diagnosed with breast cancer, underwent staging. A whole-body bone scan revealed an unexpected focal 99mTc-MDP uptake in her right ovary. Extensive literature review suggested various malignant pathologies for this incidental ovarian uptake. Despite inconclusive results from other imaging ... |
89 | bone cancer | 39,600,639 | Bone marrow mesenchymal stem cell-derived exosomes improve cancer drug delivery in human cell lines and a mouse osteosarcoma model. | Osteosarcoma is the most common primary bone tumor. Patients require chemotherapy drugs with high-targeting ability and low off-target toxicity to improve their survival. Exosomes are biological vesicles that mediate long-distance communication between cells and naturally target their source sites. Exosomes derived fro... |
90 | bone cancer | 39,600,484 | Tricuspid mass-curious case of Li-Fraumeni syndrome: A letter to the editor. | We focus specifically on the rare occurrence of cardiac thrombi in Li-Fraumeni syndrome (LFS). LFS is a hereditary risk to a diverse range of specific, uncommon, malignancies. Children and young adults have a heightened susceptibility to many malignancies, particularly soft-tissue and bone tumors, breast malignancies, ... |
91 | bone cancer | 39,600,341 | Cytogenetic profile and risk of transformation to acute myeloid leukemia (AML) in Indonesian patients with myelodysplastic syndrome (MDS): a pilot study. | Cytogenetics is a fundamental examination in the course and management of myelodysplastic syndrome (MDS) since it is widely used as a diagnostic and prognostic indicator for the disease. Some cytogenetic profiles are associated with a higher risk of acute myeloid leukemia (AML) transformation. This is the first study t... |
92 | bone cancer | 39,599,700 | Movement Behaviors and Bone Biomarkers in Young Pediatric Cancer Survivors: A Cross-Sectional Analysis of the iBoneFIT Project. | This study aims to investigate the association of movement behaviors with irisin, sclerostin, and bone turnover markers in young pediatric cancer survivors. |
93 | bone cancer | 39,598,748 | Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies. | Obesity, a prevalent global health issue, arises from an imbalance between caloric intake and energy expenditure, leading to the expansion of adipose tissue and metabolic dysfunction. White adipose tissue (WAT) stores energy as lipids, while brown adipose tissue (BAT) plays a pivotal role in energy dissipation through ... |
94 | bone cancer | 39,598,394 | Theranostics Nuclear Medicine in Prostate Cancer. | Theranostic Nuclear Medicine is based on the idea of combining the same molecule (or drug) with different radioisotopes for both diagnosis and treatment, a concept that emerged in the early 1940s with the use of radioactive iodine for thyroid diseases. Theranostic Nuclear Medicine has since expanded to diseases of high... |
95 | bone cancer | 39,598,371 | Different PSMA Radiopharmaceuticals: A Comparative Study of [ | Numerous PSMA-based tracers are used for diagnostic prostate cancer imaging, but comprehensive comparisons between multiple ligands are lacking. This study aimed to compare physiological skeletal uptake and tracer uptake in commonly recommended PSMA reference regions across three different PSMA ligands in prostate canc... |
96 | bone cancer | 39,598,066 | Surgical Textbook Outcomes in the Era of Neoadjuvant Systemic Treatment for Skin Cancers. | Recent years have brought new, highly effective systemic treatments to clinical practice, which can be used to treat patients with locally advanced or metastatic skin cancers. Using these regimens in neoadjuvant strategy influences surgical treatment by facilitating surgical resection, avoiding extensive resections wit... |
97 | bone cancer | 39,596,994 | The Potential Role of the Microbiome in the Pathogenesis of Nasal Tumors: A Comprehensive Review. | Cancers of the nose, and especially the nose vestibule, represent a significant challenge for clinicians due to their rarity, the intricate nature of surrounding vital structures, the nonspecific early symptoms, and the etiological factors that are not completely understood. Emerging research suggests that alterations ... |
98 | bone cancer | 39,596,878 | Advancements in Multiple Myeloma Research: High-Throughput Sequencing Technologies, Omics, and the Role of Artificial Intelligence. | Multiple myeloma is a complex and challenging type of blood cancer that affects plasma cells in the bone marrow. In recent years, the development of advanced research techniques, such as omics approaches-which involve studying large sets of biological data like genes and proteins-and high-throughput sequencing technolo... |
99 | bone cancer | 39,596,525 | Biallelic Germline | The use of next-generation sequencing (NGS) has recently enabled the discovery of genetic causes of primary ovarian insufficiency (POI) with high genetic heterogeneity. In contrast, the causes of diminished ovarian reserve (DOR) remain poorly understood. Here, we identified by NGS and whole exome sequencing (WES) the c... |
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