{
  "assays": 217,
  "combined_scores": "full217_cytolexmuta_scores.csv.gz",
  "created_on": "2026-08-15",
  "formula": "0.5*robust_z(0.5*ESM-C+0.5*ProSST)+0.25*robust_z(GEMME)+0.25*robust_z(ESM-IF1)",
  "method_name": "cytolexmuta",
  "optimizer_steps": 0,
  "per_assay_score_dir": "scores/cytolexmuta",
  "performance": {
    "function_category_spearman": {
      "Activity": 0.5242,
      "Binding": 0.46937500000000004,
      "Expression": 0.5368333333333334,
      "OrganismalFitness": 0.49091015625,
      "Stability": 0.6523181818181819
    },
    "official_function_balanced_spearman_3dp": 0.535,
    "official_function_balanced_spearman_unrounded": 0.5347273342803031
  },
  "schema": "cytolexmuta_submission_package_v1",
  "score_bundle": "cytolexmuta_scores_full217.tar.gz",
  "score_column": "cytolexmuta",
  "source_metric_artifact": "artifacts/official_benchmark/pg_zero_shot_esm_if1_fixed_fusion_v1_20260813/summary.json",
  "source_prediction_artifact": "artifacts/official_benchmark/pg_zero_shot_esm_if1_predictions_v1_20260813/full217_predictions.csv.gz",
  "status": "prepared_pending_gemme_provenance_decision",
  "submission_blockers": [
    {
      "blocker": "GEMME/JET2 provenance/license decision",
      "recommended_resolution": "Submit as a score-level ensemble referencing ProteinGym GEMME baseline without redistributing GEMME/JET2, or obtain explicit GEMME/JET2 provenance before claiming independent runtime reproduction."
    }
  ],
  "target_columns_in_scores": false,
  "training": false,
  "validation": {
    "no_cryptographic_hashing": true,
    "per_assay_files": 217,
    "sample_headers": {
      "A0A140D2T1_ZIKV_Sourisseau_2019.csv": [
        "mutant",
        "cytolexmuta"
      ],
      "A0A192B1T2_9HIV1_Haddox_2018.csv": [
        "mutant",
        "cytolexmuta"
      ],
      "A0A1I9GEU1_NEIME_Kennouche_2019.csv": [
        "mutant",
        "cytolexmuta"
      ]
    },
    "validated_rows": 2465767
  },
  "variant_rows": 2465767
}