### FUNCTION Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines Requires NADPH, but not NADH, as an electron donor for its activity ### SEQUENCE -M-K-G-L-I-I-I-G-S-A-Q-V-N-S-H-T-S-A-L-A-R-Y-L-T-E-H-F-K-T-H-D-I-E-A-E-I-F-D-L-A-E-K-P-L-N-Q-L-D-F-S-G-T-T-P-S-I-D-E-I-K-Q-N-M-K-D-L-K-E-K-A-M-A-A-D-F-L-I-L-G-T-P-N-Y-H-G-S-Y-S-G-I-L-K-N-A-L-D-H-L-N-M-D-Y-F-K-M-K-P-V-G-L-I-G-N-S-G-G-I-V-S-S-E-P-L-S-H-L-R-V-I-V-R-S-L-L-G-I-A-V-P-T-Q-I-A-T-H-D-S-D-F-A-K-N-E-D-G-S-Y-Y-L-N-D-S-E-F-Q-L-R-A-R-L-F-V-D-Q-I-V-S-F-V-N-N-S-P-Y-E-H-L-K


### FUNCTION Virulence factor that is important for the establishment of infection in the host EsxA is required for EsxB synthesis as well as secretion ### SEQUENCE -M-A-M-I-K-M-S-P-E-E-I-R-A-K-S-Q-S-Y-G-Q-G-S-D-Q-I-R-Q-I-L-S-D-L-T-R-A-Q-G-E-I-A-A-N-W-E-G-Q-A-F-S-R-F-E-E-Q-F-Q-Q-L-S-P-K-V-E-K-F-A-Q-L-L-E-E-I-K-Q-Q-L-N-S-T-A-D-A-V-Q-E-Q-D-Q-Q-L-S-N-N-F-G-L-Q


### FUNCTION Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine ### SEQUENCE -M-V-K-P-R-Q-R-E-Y-P-T-L-K-S-S-L-N-I-V-R-E-T-A-L-I-A-I-S-C-V-F-W-I-Y-C-L-V-V-L-L-V-Y-I-G-T-I-F-E-I-H-D-E-S-I-N-T-I-R-V-A-L-N-I-E-N-T-E-I-L-D-I-F-E-T-M-G-I-F-A-I-I-I-F-V-F-F-T-I-S-I-L-I-Q-K-W-Q-R-G-R-E-S


### FUNCTION Represses transcription of the icaADBC operon necessary for biofilm production ### SEQUENCE -M-K-D-K-I-I-D-N-A-I-T-L-F-S-E-K-G-Y-D-G-T-T-L-D-D-I-A-K-S-V-N-I-K-K-A-S-L-Y-Y-H-F-D-S-K-K-S-I-Y-E-Q-S-V-K-C-C-F-D-Y-L-N-N-I-I-M-M-N-Q-N-K-S-N-Y-S-I-D-A-L-Y-Q-F-L-F-E-F-I-F-D-I-E-E-R-Y-I-R-M-Y-V-Q-L-S-N-T-P-E-E-F-S-G-N-I-Y-G-Q-I-Q-D-L-N-Q-S-L-S-K-E-I-A-K-F-Y-D-E-S-K-I-K-M-T-K-E-D-F-Q-N-L-I-L-L-F-L-E-S-W-Y-L-K-A-S-F-S-Q-K-F-G-A-V-E-E-S-K-S-Q-F-K-D-E-V-Y-S-L-L-N-I-F-L-K-K


### FUNCTION Negative regulator of sarA transcription at late exponential and stationary growth phases It contributes to the modulation of target genes downstream of the sarA regulatory cascade Also, positively regulates expression of primary transcripts RNAII and RNAIII generated by agr ### SEQUENCE -M-S-K-I-N-D-I-N-D-L-V-N-A-T-F-Q-V-K-K-F-F-R-D-T-K-K-K-F-N-L-N-Y-E-E-I-Y-I-L-N-H-I-L-R-S-E-S-N-E-I-S-S-K-E-I-A-K-C-S-E-F-K-P-Y-Y-L-T-K-A-L-Q-K-L-K-D-L-K-L-L-S-K-K-R-S-L-Q-D-E-R-T-V-I-V-Y-V-T-D-T-Q-K-A-N-I-Q-K-L-I-S-E-L-E-E-Y-I-K-N


### FUNCTION Involved in multidrug efflux ### SEQUENCE -M-I-V-N-Y-L-K-H-K-F-Y-N-L-L-T-T-M-I-V-L-F-I-F-V-L-S-G-A-I-F-L-T-F-L-G-F-G-L-Y-G-L-S-R-I-L-I-Y-F-R-L-G-D-F-T-Y-N-R-S-M-Y-D-N-L-L-Y-Y-G-S-Y-I-I-F-G-Y-F-I-I-F-A-V-E-H-L-M-D-Y-F-R-K-M-L-P-E-N-A-Y-F-R-G-A-T-F-H-L-I-S-Y-T-V-A-T-T-L-F-Y-F-I-I-H-L-N-Y-V-Y-I-N-I-D-F-W-V-I-M-V-I-I-G-F-L-Y-V-C-K-L-Q-F-Y-P-E-S-K-N-L-N-N-R-K


### FUNCTION Toxic component of a type II toxin-antitoxin  system Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA Neutralized by coexpression with cognate antitoxin MazE ### SEQUENCE -M-I-R-R-G-D-V-Y-L-A-D-L-S-P-V-Q-G-S-E-Q-G-G-V-R-P-V-V-I-I-Q-N-D-T-G-N-K-Y-S-P-T-V-I-V-A-A-I-T-G-R-I-N-K-A-K-I-P-T-H-V-E-I-E-K-K-K-Y-K-L-D-K-D-S-V-I-L-L-E-Q-I-R-T-L-D-K-K-R-L-K-E-K-L-T-Y-L-S-D-D-K-M-K-E-V-D-N-A-L-M-I-S-L-G-L-N-A-V-A-H-Q-K-N


### FUNCTION Signal transduction protein, which is a major regulator of staphylococcal pathogenesis Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors Up-regulates the expression of most toxins and genes known to be necessary for biofilm formation ### SEQUENCE -M-K-K-L-Y-T-S-Y-G-T-Y-G-F-L-H-Q-I-K-I-N-N-P-T-H-Q-L-F-Q-F-S-A-S-D-T-S-V-I-F-E-E-T-D-G-E-T-V-L-K-S-P-S-I-Y-E-V-I-K-E-I-G-E-F-S-E-H-H-F-Y-C-A-I-F-I-P-S-T-E-D-H-A-Y-Q-L-E-K-K-L-I-S-V-D-D-N-F-R-N-F-G-G-F-K-S-Y-R-L-L-R-P-A-K-G-T-T-Y-K-I-Y-F-G-F-A-D-R-H-A-Y-E-D-F-K-Q-S-D-A-F-N-D-H-F-S-K-D-A-L-S-H-Y-F-G-S-S-G-Q-H-S-S-Y-F-E-R-Y-L-Y-P-I-K-E


### FUNCTION Involved in cold stress response ### SEQUENCE -M-K-Q-G-T-V-K-W-F-N-A-E-K-G-F-G-F-I-E-V-E-G-E-N-D-V-F-V-H-F-S-A-I-N-Q-D-G-Y-K-S-L-E-E-G-Q-A-V-E-F-E-V-V-E-G-D-R-G-P-Q-A-A-N-V-V-K-L


### FUNCTION Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner ### SEQUENCE -M-A-I-T-K-I-N-D-C-F-E-L-L-S-M-V-T-Y-A-D-K-L-K-S-L-I-K-K-E-F-S-I-S-F-E-E-F-A-V-L-T-Y-I-S-E-N-K-E-K-E-Y-Y-L-K-D-I-I-N-H-L-N-Y-K-Q-P-Q-V-V-K-A-V-K-I-L-S-Q-E-D-Y-F-D-K-K-R-N-E-H-D-E-R-T-V-L-I-L-V-N-A-Q-Q-R-K-K-I-E-S-L-L-S-R-V-N-K-R-I-T-E-A-N-N-E-I-E-L


### FUNCTION Catalyzes the acylation of glycosyl-4,4'-diaponeurosporenoate, ie the esterification of glucose at the C6'' position with the carboxyl group of the C ### SEQUENCE -M-K-T-M-K-K-Y-I-K-T-A-F-F-C-S-M-Y-W-L-I-V-Q-L-N-I-A-N-L-G-T-R-I-P-D-K-Y-F-R-Q-K-Y-I-I-F-K-S-F-N-F-E-K-H-G-K-F-W-N-K-W-F-Y-V-R-K-W-K-H-K-I-L-D-G-H-Q-L-N-Q-N-I-Y-D-Q-R-H-L-M-T-I-N-T-D-E-I-E-K-M-I-I-E-T-K-R-A-E-L-I-H-W-I-S-I-L-P-V-I-I-F-N-K-G-S-R-L-V-K-Y-I-N-I-F-Y-A-M-I-A-N-V-P-I-I-I-V-Q-R-Y-N-R-P-R-L-T-Q-L-L-R-I-L-K-R-R-G-E-R-H-D


### FUNCTION Chaperone that serves for the intracellular sequestration and transport of Cu ### SEQUENCE -M-S-Q-E-I-L-N-V-E-G-M-S-C-G-H-C-K-S-A-V-E-S-A-L-N-N-I-D-G-V-T-S-A-D-V-N-L-E-N-G-Q-V-S-V-Q-Y-D-D-S-K-V-A-V-S-Q-M-K-D-A-I-E-D-Q-G-Y-D-V-V


### FUNCTION Transcriptional regulator acting as an intermediary between major regulators SarA and agr and virulence genes Represses alpha-hemolysin ### SEQUENCE -M-N-D-L-K-S-K-S-N-I-K-L-M-K-R-V-L-T-T-Y-E-L-R-K-Y-L-K-K-Y-F-C-L-T-L-D-N-Y-L-V-L-A-Y-L-D-V-F-K-N-D-E-G-K-Y-F-M-R-D-I-I-S-Y-I-G-I-D-Q-S-R-I-V-K-S-V-K-E-L-S-K-K-G-Y-L-N-K-C-R-D-P-H-D-S-R-N-V-I-I-V-V-S-V-K-Q-H-N-Y-I-K-N-L-L-S-E-I-N-I-N-E-T


### FUNCTION Activates transcription of virulence factors alpha- and beta hemolysin genes ### SEQUENCE -M-Y-V-E-N-S-Y-L-S-K-Q-L-C-F-L-F-Y-V-S-S-K-E-I-I-K-K-Y-T-N-Y-L-K-E-Y-D-L-T-Y-T-G-Y-I-V-L-M-A-I-E-N-D-E-K-L-N-I-K-K-L-G-E-R-V-F-L-D-S-G-T-L-T-P-L-L-K-K-L-E-K-K-D-Y-V-V-R-T-R-E-E-K-D-E-R-N-L-Q-I-S-L-T-E-Q-G-K-A-I-K-S-P-L-A-E-I-S-V-K-V-F-N-E-F-N-I-S-E-R-E-A-S-D-I-I-N-N-L-R-N-F-V-S-K-N-F-D-Y-S-D-R-K


### FUNCTION Involved in urease metallocenter assembly Binds nickel Probably functions as a nickel donor during metallocenter assembly ### SEQUENCE -M-I-V-E-E-I-Q-G-N-I-A-N-L-S-N-S-E-K-Q-K-H-V-E-K-V-Y-L-E-N-S-D-L-V-K-R-I-Q-R-V-V-T-D-H-G-T-E-I-G-I-R-L-K-Q-P-I-D-L-Q-Y-G-D-I-L-Y-A-D-D-H-N-M-I-I-V-D-V-N-S-E-D-L-L-V-I-Q-P-R-T-L-Q-E-M-G-D-I-A-H-Q-L-G-N-R-H-L-P-A-Q-F-T-E-T-E-M-L-V-Q-Y-D-Y-L-V-E-D-L-L-K-S-L-G-I-P-Y-V-R-E-D-R-K-V-N-K-A-F-R-H-I-G-H-S-H-D


### FUNCTION Part of the pathway by which MgrA and SarA control autolysis ### SEQUENCE -M-S-N-K-V-Q-R-F-I-E-A-E-R-E-L-S-Q-L-K-H-W-L-K-T-T-H-K-I-S-I-E-E-F-V-V-L-F-K-V-Y-E-A-E-K-I-S-G-K-E-L-R-D-T-L-H-F-E-M-L-W-D-T-S-K-I-D-V-I-I-R-K-I-Y-K-K-E-L-I-S-K-L-R-S-E-T-D-E-R-Q-V-F-Y-F-Y-S-T-S-Q-K-K-L-L-D-K-I-T-K-E-I-E-V-L-S-V-T-N


### FUNCTION One of the early assembly proteins it binds 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome Forms the main docking site for trigger factor binding to the ribosome ### SEQUENCE -M-E-A-R-D-I-L-K-R-P-V-I-T-E-K-S-S-E-A-M-A-E-D-K-Y-T-F-D-V-D-T-R-V-N-K-T-Q-V-K-M-A-V-E-E-I-F-N-V-K-V-A-S-V-N-I-M-N-Y-K-P-K-K-K-R-M-G-R-Y-Q-G-Y-T-N-K-R-R-K-A-I-V-T-L-K-E-G-S-I-D-L-F-N


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-E-A-K-A-V-A-R-T-I-R-I-A-P-R-K-V-R-L-V-L-D-L-I-R-G-K-N-A-A-E-A-I-A-I-L-K-L-T-N-K-A-S-S-P-V-I-E-K-V-L-M-S-A-L-A-N-A-E-H-N-Y-D-M-N-T-D-E-L-V-V-K-E-A-Y-A-N-E-G-P-T-L-K-R-F-R-P-R-A-Q-G-R-A-S-A-I-N-K-R-T-S-H-I-T-I-V-V-S-D-G-K-E-E-A-K-E-A


### FUNCTION Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs ### SEQUENCE -M-L-L-P-K-R-V-K-Y-R-R-Q-H-R-P-K-T-T-G-R-S-K-G-G-N-Y-V-T-F-G-E-F-G-L-Q-A-T-T-T-S-W-I-T-S-R-Q-I-E-S-A-R-I-A-M-T-R-Y-M-K-R-G-G-K-V-W-I-K-I-F-P-H-T-P-Y-T-K-K-P-L-E-V-R-M-G-A-G-K-G-A-V-E-G-W-I-A-V-V-K-P-G-R-I-L-F-E-V-A-G-V-S-E-E-V-A-R-E-A-L-R-L-A-S-H-K-L-P-V-K-T-K-F-V-K-R-E-E-L-G-G-E-T-N-E-S


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-S-E-R-N-D-R-K-V-Y-V-G-K-V-V-S-D-K-M-D-K-T-I-T-V-L-V-E-T-Y-K-T-H-K-L-Y-G-K-R-V-K-Y-S-K-K-Y-K-T-H-D-E-N-N-S-A-K-L-G-D-I-V-K-I-Q-E-T-R-P-L-S-A-T-K-R-F-R-I-V-E-I-V-E-E-S-V-I-I


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-Q-E-T-R-L-K-V-A-D-N-S-G-A-R-E-V-L-T-I-K-V-L-G-G-S-G-R-K-T-A-N-I-G-D-V-I-V-C-T-V-K-N-A-T-P-G-G-V-V-K-K-G-D-V-V-K-A-V-I-V-R-T-K-S-G-V-R-R-N-D-G-S-Y-I-K-F-D-E-N-A-C-V-I-I-R-D-D-K-G-P-R-G-T-R-I-F-G-P-V-A-R-E-L-R-E-G-N-F-M-K-I-V-S-L-A-P-E-V-L


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-N-R-L-K-E-K-F-N-T-E-V-T-E-N-L-M-K-K-F-N-Y-S-S-V-M-E-V-P-K-I-D-K-I-V-V-N-M-G-V-G-D-A-V-Q-N-S-K-V-L-D-N-A-V-E-E-L-E-L-I-T-G-Q-K-P-L-V-T-K-A-K-K-S-I-A-T-F-R-L-R-E-G-M-P-I-G-A-K-V-T-L-R-G-E-R-M-Y-E-F-L-D-K-L-I-S-V-S-L-P-R-V-R-D-F-Q-G-V-S-K-K-A-F-D-G-R-G-N-Y-T-L-G-V-K-E-Q-L-I-F-P-E-I-D-Y-D-K-V-S-K-V-R-G-M-D-I-V-I-V-T-T-A-N-T-D-E-E-A-R-E-L-L-A-N-F-G-M-P-F-R-K


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-S-R-V-G-K-K-I-I-D-I-P-S-D-V-T-V-T-F-D-G-N-H-V-T-V-K-G-P-K-G-E-L-S-R-T-L-N-E-R-M-T-F-K-Q-E-E-N-T-I-E-V-V-R-P-S-D-S-K-E-D-R-T-N-H-G-T-T-R-A-L-L-N-N-M-V-Q-G-V-S-Q-G-Y-V-K-V-L-E-L-V-G-V-G-Y-R-A-Q-M-Q-G-K-D-L-I-L-N-V-G-Y-S-H-P-V-E-I-K-A-E-E-N-I-T-F-S-V-E-K-N-T-V-V-K-V-E-G-I-S-K-E-Q-V-G-A-L-A-S-N-I-R-S-V-R-P-P-E-P-Y-K-G-K-G-I-R-Y-Q-G-E-Y-V-R-R-K-E-G-K-T-G-K


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-I-S-K-I-D-K-N-K-V-R-L-K-R-H-A-R-V-R-T-N-L-S-G-T-A-E-K-P-R-L-N-V-Y-R-S-N-K-H-I-Y-A-Q-I-I-D-D-N-K-G-V-T-L-A-Q-A-S-S-K-D-S-D-I-A-T-T-A-T-K-V-E-L-A-T-K-V-G-E-A-I-A-K-K-A-A-D-K-G-I-K-E-I-V-F-D-R-G-G-Y-L-Y-H-G-R-V-K-A-L-A-E-A-A-R-E-S-G-L-E-F


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-R-Q-T-F-M-A-N-E-S-N-I-E-R-K-W-Y-V-I-D-A-E-G-Q-T-L-G-R-L-S-S-E-V-A-S-I-L-R-G-K-N-K-V-T-Y-T-P-H-V-D-T-G-D-Y-V-I-V-I-N-A-S-K-I-E-F-T-G-N-K-E-T-D-K-V-Y-Y-R-H-S-N-H-P-G-G-I-K-S-I-T-A-G-E-L-R-R-T-N-P-E-R-L-I-E-N-S-I-K-G-M-L-P-S-T-R-L-G-E-K-Q-G-K-K-L-F-V-Y-G-G-A-E-H-P-H-A-A-Q-Q-P-E-N-Y-E-L-R-G


### FUNCTION Involved in multidrug efflux ### SEQUENCE -M-I-V-N-Y-L-K-H-K-F-Y-N-L-L-T-T-M-I-V-L-F-I-F-V-L-S-G-A-I-F-L-T-F-L-G-F-G-L-Y-G-L-S-R-I-L-I-Y-F-R-L-G-D-F-T-Y-N-R-S-M-Y-D-N-L-L-Y-Y-G-S-Y-I-I-F-G-Y-F-I-I-F-A-V-E-H-L-M-D-Y-F-R-K-M-L-P-E-N-A-Y-F-R-G-A-T-F-H-L-I-S-Y-T-V-A-T-T-L-F-Y-F-I-I-H-L-N-Y-V-Y-I-N-I-D-F-W-V-I-M-V-I-I-G-F-L-Y-V-C-K-L-Q-F-Y-P-E-S-K-N-L-N-N-R-K


### FUNCTION Dephosphorylates the phosphotyrosine-containing proteins ### SEQUENCE -M-K-I-L-F-V-C-T-G-N-T-C-R-S-P-L-A-E-S-I-A-K-E-V-M-P-N-H-Q-F-E-S-R-G-I-F-A-V-N-N-Q-G-V-S-N-Y-V-E-D-L-V-E-E-H-H-L-A-E-T-T-L-S-Q-Q-F-T-E-A-D-L-K-A-D-I-I-L-T-M-S-Y-S-H-K-E-L-I-E-A-H-F-G-L-Q-N-H-V-F-T-L-H-E-Y-V-K-E-A-G-E-V-I-D-P-Y-G-G-T-K-E-M-Y-V-H-T-Y-E-E-L-V-S-L-I-L-K-L-K-D-I-I-C


### FUNCTION Antitoxin component of a type II toxin-antitoxin  system Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity ### SEQUENCE -M-L-S-F-S-Q-N-R-S-H-S-L-E-Q-S-L-K-E-G-Y-S-Q-M-A-D-L-N-L-S-L-A-N-E-A-F-P-I-E-C-E-A-C-D-C-N-E-T-Y-L-S-S-N-S-T-N-E


### FUNCTION Secreted tyrosine phosphatase that plays a critical role during infection as a bacterial effector protein that counteracts host defenses Required for intramacrophage survival ### SEQUENCE -M-V-D-V-A-F-V-C-L-G-N-I-C-R-S-P-M-A-E-A-I-M-R-Q-R-L-K-D-R-N-I-H-D-I-K-V-H-S-R-G-T-G-S-W-N-L-G-E-P-P-H-E-G-T-Q-K-I-L-N-K-H-N-I-P-F-D-G-M-I-S-E-L-F-E-A-T-D-D-F-D-Y-I-V-A-M-D-Q-S-N-V-D-N-I-K-S-I-N-P-N-L-K-G-Q-L-F-K-L-L-E-F-S-N-M-E-E-S-D-V-P-D-P-Y-Y-T-N-N-F-E-G-V-Y-D-M-V-L-S-S-C-D-N-L-I-D-Y-I-V-K-D-A-N-L-K-E-G


### FUNCTION Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins May act as a hydrogen peroxide and organic hydroperoxide sensor ### SEQUENCE -M-S-V-E-I-E-S-I-E-H-E-L-E-E-S-I-A-S-L-R-Q-A-G-I-R-I-T-P-Q-R-Q-A-I-L-R-Y-L-I-S-S-H-T-H-P-T-A-D-E-I-Y-Q-A-L-S-P-D-F-P-N-I-S-V-A-T-I-Y-N-N-L-R-V-F-K-D-I-G-I-V-K-E-L-T-Y-G-D-S-S-S-R-F-D-F-N-T-H-N-H-Y-H-I-I-C-E-Q-C-G-K-I-V-D-F-Q-Y-P-Q-L-N-E-I-E-R-L-A-Q-H-M-T-D-F-D-V-T-H-H-R-M-E-I-Y-G-V-C-K-E-C-Q-D-K


### FUNCTION Signal transduction protein, which is a major regulator of staphylococcal pathogenesis Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors Up-regulates the expression of most toxins and genes known to be necessary for biofilm formation ### SEQUENCE -M-K-K-L-Y-T-S-Y-G-T-Y-G-F-L-H-Q-I-K-I-N-N-P-T-H-Q-L-F-Q-F-S-A-S-D-T-S-V-I-F-E-E-T-D-G-E-T-V-L-K-S-P-S-I-Y-E-V-I-K-E-I-G-E-F-S-E-H-H-F-Y-C-A-I-F-I-P-S-T-E-D-H-A-Y-Q-L-E-K-K-L-I-S-V-D-D-N-F-R-N-F-G-G-F-K-S-Y-R-L-L-R-P-A-K-G-T-T-Y-K-I-Y-F-G-F-A-D-R-H-A-Y-E-D-F-K-Q-S-D-A-F-N-D-H-F-S-K-D-A-L-S-H-Y-F-G-S-S-G-Q-H-S-S-Y-F-E-R-Y-L-Y-P-I-K-E


### FUNCTION Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival ### SEQUENCE -M-K-F-N-D-V-Y-N-K-H-H-K-I-I-H-H-L-L-K-K-Y-N-I-S-Y-N-Y-D-E-Y-Y-Q-L-L-L-I-K-M-W-Q-L-S-Q-I-Y-K-P-S-S-K-Q-S-L-S-S-F-L-F-T-R-L-N-Y-Y-L-I-D-L-F-R-Q-Q-N-Q-L-K-D-V-I-L-C-E-N-N-S-P-T-L-T-E-Q-P-T-Y-F-N-E-H-D-L-R-L-Q-D-I-F-K-L-L-N-H-R-E-R-L-W-L-K-L-Y-L-E-G-Y-K-Q-F-E-I-A-E-I-M-S-L-S-L-S-T-I-K-L-I-K-M-S-V-K-R-K-C-Q-H-N-F-N


### FUNCTION Global regulator with both positive and negative effects that mediates modulation of several genes involved in virulence Also, modulates the expression of genes not previously implicated in pathogenesis ### SEQUENCE -M-H-K-L-A-H-T-S-F-G-I-V-G-M-F-V-N-T-C-M-V-A-K-Y-V-I-I-N-W-E-M-F-S-M-K-K-V-N-N-D-T-V-F-G-I-L-Q-L-E-T-L-L-G-D-I-N-S-I-F-S-E-I-E-S-E-Y-K-M-S-R-E-E-I-L-I-L-L-T-L-W-Q-K-G-S-M-T-L-K-E-M-D-R-F-V-E-V-K-P-Y-K-R-T-R-T-Y-N-N-L-V-E-L-E-W-I-Y-K-E-R-P-V-D-D-E-R-T-V-I-I-H-F-N-E-K-L-Q-Q-E-K-V-E-L-L-N-F-I-S-D-A-I-A-S-R-A-T-A-M-Q-N-S-L-N-A-I-I-A-V


### FUNCTION This protein binds to 23S rRNA in the presence of protein L20 ### SEQUENCE -M-F-A-I-I-E-T-G-G-K-Q-I-K-V-E-E-G-Q-E-I-F-V-E-K-L-D-V-N-E-G-D-T-F-T-F-D-K-V-L-F-V-G-G-D-S-V-K-V-G-A-P-T-V-E-G-A-T-V-T-A-T-V-N-K-Q-G-R-G-K-K-I-T-V-F-T-Y-K-R-R-K-N-S-K-R-K-K-G-H-R-Q-P-Y-T-K-L-T-I-D-K-I-N-A


### FUNCTION Binds directly to 16S ribosomal RNA ### SEQUENCE -M-A-N-I-K-S-A-I-K-R-V-K-T-T-E-K-A-E-A-R-N-I-S-Q-K-S-A-M-R-T-A-V-K-N-A-K-T-A-V-S-N-N-A-D-N-K-N-E-L-V-S-L-A-V-K-L-V-D-K-A-A-Q-S-N-L-I-H-S-N-K-A-D-R-I-K-S-Q-L-M-T-A-N-K


### FUNCTION Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions ### SEQUENCE -M-N-K-T-D-L-I-N-A-V-A-E-Q-A-D-L-T-K-K-E-A-G-S-A-V-D-A-V-F-E-S-I-Q-N-S-L-A-K-G-E-K-V-Q-L-I-G-F-G-N-F-E-V-R-E-R-A-A-R-K-G-R-N-P-Q-T-G-K-E-I-D-I-P-A-S-K-V-P-A-F-K-A-G-K-A-L-K-D-A-V-K


### FUNCTION Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed Also contributes to the recruitment of PBP1 to the division complex Not essential for septum formation ### SEQUENCE -M-S-D-V-S-L-K-L-S-A-K-D-I-Y-E-K-D-F-E-K-T-M-A-R-G-Y-R-R-E-E-V-D-A-F-L-D-D-I-I-A-D-Y-Q-K-M-A-D-M-N-N-E-V-V-K-L-S-E-E-N-H-K-L-K-K-E-L-E-E-L-R-L-R-V-A-T-S-R-P-Q-D-N-K-S-F-S-S-N-N-T-T-T-N-T-S-S-N-N-V-D-I-L-K-R-I-S-N-L-E-K-A-V-F-G-K


### FUNCTION Involved in cold stress response ### SEQUENCE -M-K-Q-G-T-V-K-W-F-N-A-E-K-G-F-G-F-I-E-V-E-G-E-N-D-V-F-V-H-F-S-A-I-N-Q-D-G-Y-K-S-L-E-E-G-Q-A-V-E-F-E-V-V-E-G-D-R-G-P-Q-A-A-N-V-V-K-L


### FUNCTION Accessory element involved in the expression of sarA and several virulence factors Modulates SarA production and/or function in a strain-dependent manner Affects the transcription of the accessory gene regulator ### SEQUENCE -M-K-Y-L-I-L-S-L-V-A-N-L-L-V-F-G-V-L-S-A-I-G-L-N-I-N-I-L-A-A-M-M-I-V-L-V-I-P-I-M-I-S-G-I-L-F-F-K-T-N-I-D-K-T-Y-I-F-F-N-I-I-F-I-D-F-Y-Y-Y-I-Y-N-V-H-L-M-T-L-P-K-F-N-N-Y-I-K-A-E-M-M-E-L-E-D-I-D-V-L-I-T-S-K-D-F-G-F-D-E-I-L-F-Y-T-L-Y-L-L-L-I-L-I-V-L-Y-Y-L-K-K-Q-V-K-H-K-I


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA ### SEQUENCE -M-A-I-S-Q-E-R-K-N-E-I-I-K-E-Y-R-V-H-E-T-D-T-G-S-P-E-V-Q-I-A-V-L-T-A-E-I-N-A-V-N-E-H-L-R-T-H-K-K-D-H-H-S-R-R-G-L-L-K-M-V-G-R-R-R-H-L-L-N-Y-L-R-S-K-D-I-Q-R-Y-R-E-L-I-K-S-L-G-I-R-R


### FUNCTION Cell division protein that is part of the divisome complex and is recruited early to the Z-ring Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments Its function overlaps with FtsA ### SEQUENCE -M-S-H-L-A-L-K-D-L-F-S-G-F-F-V-I-D-D-E-E-E-V-E-V-P-D-K-Q-Q-Q-V-N-E-A-P-A-K-E-Q-S-Q-Q-T-T-K-Q-N-A-I-K-S-V-P-Q-K-S-A-S-R-Y-T-T-T-S-E-E-R-N-N-R-M-S-N-Y-S-K-N-N-S-R-N-V-V-T-M-N-N-A-T-P-N-N-A-S-Q-E-S-S-K-M-C-L-F-E-P-R-V-F-S-D-T-Q-D-I-A-D-E-L-K-N-R-R-A-T-L-V-N-L-Q-R-I-D-K-V-S-A-K-R-I-I-D-F-L-S-G-T-V-Y-A-I-G-G-D-I-Q-R-V-G-T-D-I-F-L-C-T-P-D-N-V-E-V-A-G-S-I-T-D-H-I-E-N-M-E-H-S-F-D


### FUNCTION May be involved in countering the first line of host defense mechanisms Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 ### SEQUENCE -M-K-K-N-I-T-K-T-I-I-A-S-T-V-I-A-A-G-L-L-T-Q-T-N-D-A-K-A-F-F-S-Y-E-W-K-G-L-E-I-A-K-N-L-A-D-Q-A-K-K-D-D-E-R-I-D-K-L-M-K-E-S-D-K-N-L-T-P-Y-K-A-E-T-V-N-D-L-Y-L-I-V-K-K-L-S-Q-G-D-V-K-K-A-V-V-R-I-K-D-G-G-P-R-D-Y-Y-T-F-D-L-T-R-P-L-E-E-N-R-K-N-I-K-V-V-K-N-G-E-I-D-S-I-Y-W-D


### FUNCTION Catalyzes quinol oxidation with the concomitant reduction of oxygen to water ### SEQUENCE -M-S-T-I-M-K-H-T-V-G-F-I-A-S-I-V-L-T-L-L-A-V-Y-V-T-L-Y-T-S-L-T-F-H-A-K-L-T-I-I-F-G-F-A-F-V-Q-A-G-L-Q-L-L-M-F-M-H-L-T-E-G-K-D-G-R-L-Q-T-F-K-V-I-F-A-L-V-I-T-L-C-F-V-V-G-T-Y-W-V-M-Q-G-G-H-S-S-H-L


### FUNCTION Specifically inhibits the cysteine protease staphopain B ### SEQUENCE -M-Y-Q-L-Q-F-I-N-L-V-Y-D-T-T-K-L-T-H-L-E-Q-T-N-I-N-L-F-I-G-N-W-S-N-H-Q-L-Q-K-S-I-C-I-R-H-G-D-D-T-S-H-N-Q-Y-H-I-L-F-I-D-T-A-H-Q-R-I-K-F-S-S-I-D-N-E-E-I-T-Y-I-L-D-Y-D-D-T-Q-H-I-L-M-Q-T-S-S-K-Q-G-I-G-T-S-R-P-I-V-Y-E-R-L-V


### FUNCTION PPIases accelerate the folding of proteins It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ### SEQUENCE -M-A-N-Y-P-Q-L-N-K-E-V-Q-Q-G-E-I-K-V-V-M-H-T-N-K-G-D-M-T-F-K-L-F-P-N-I-A-P-K-T-V-E-N-F-V-T-H-A-K-N-G-Y-Y-D-G-I-T-F-H-R-V-I-N-D-F-M-I-Q-G-G-D-P-T-A-T-G-M-G-G-E-S-I-Y-G-G-A-F-E-D-E-F-S-L-N-A-F-N-L-Y-G-A-L-S-M-A-N-S-G-P-N-T-N-G-S-Q-F-F-I-V-Q-M-K-E-V-P-Q-N-M-L-S-Q-L-A-D-G-G-W-P-Q-P-I-V-D-A-Y-G-E-K-G-G-T-P-W-L-D-Q-K-H-T-V-F-G-Q-I-I-D-G-E-T-T-L-E-D-I-A-N-T-K-V-G-P-Q-D-K-P-L-H-D-V-V-I-E-S-I-D-V-E-E


### FUNCTION Involved in protein export Participates in an early event of protein translocation ### SEQUENCE -M-H-T-F-L-I-V-L-L-I-I-D-C-I-A-L-I-T-V-V-L-L-Q-E-G-K-S-S-G-L-S-G-A-I-S-G-G-A-E-Q-L-F-G-K-Q-K-Q-R-G-V-D-L-F-L-N-R-L-T-I-I-L-S-I-L-F-F-V-L-M-I-C-I-S-Y-L-G-M


### FUNCTION Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase ### SEQUENCE -M-I-R-F-E-I-H-G-D-N-L-T-I-T-D-A-I-R-N-Y-I-E-E-K-I-G-K-L-E-R-Y-F-N-D-V-P-N-A-V-A-H-V-K-V-K-T-Y-S-N-S-A-T-K-I-E-V-T-I-P-L-K-N-V-T-L-R-A-E-E-R-N-D-D-L-Y-A-G-I-D-L-I-N-N-K-L-E-R-Q-V-R-K-Y-K-T-R-I-N-R-K-S-R-D-R-G-D-Q-E-V-F-V-A-E-L-Q-E-M-Q-E-T-Q-V-D-N-D-A-Y-D-D-N-E-I-E-I-I-R-S-K-E-F-S-L-K-P-M-D-S-E-E-A-V-L-Q-M-N-L-L-G-H-D-F-F-V-F-T-D-R-E-T-D-G-T-S-I-V-Y-R-R-K-D-G-K-Y-G-L-I-Q-T-S-E-Q


### FUNCTION Regulatory protein involved in autolytic activity, multidrug resistance and virulence ### SEQUENCE -M-S-D-Q-H-N-L-K-E-Q-L-C-F-S-L-Y-N-A-Q-R-Q-V-N-R-Y-Y-S-N-K-V-F-K-K-Y-N-L-T-Y-P-Q-F-L-V-L-T-I-L-W-D-E-S-P-V-N-V-K-K-V-V-T-E-L-A-L-D-T-G-T-V-S-P-L-L-K-R-M-E-Q-V-D-L-I-K-R-E-R-S-E-V-D-Q-R-E-V-F-I-H-L-T-D-K-S-E-T-I-R-P-E-L-S-N-A-S-D-K-V-A-S-A-S-S-L-S-Q-D-E-V-K-E-L-N-R-L-L-G-K-V-I-H-A-F-D-E-T-K-E-K


### FUNCTION Involved in the regulation of virulence genes Acts as a repressor of the agr locus and consequently targets genes regulated by the agr system such as sspA, hla and hlb Binds directly to the agr promoter region ### SEQUENCE -M-N-T-E-K-L-E-T-L-L-G-F-Y-K-Q-Y-K-A-L-S-E-Y-I-D-K-K-Y-K-L-S-L-N-D-L-A-V-L-D-L-T-M-K-H-C-K-D-E-K-V-L-M-Q-S-F-L-K-T-A-M-D-E-L-D-L-S-R-T-K-L-L-V-S-I-R-R-L-I-E-K-E-R-L-S-K-V-R-S-S-K-D-E-R-K-I-Y-I-Y-L-N-N-D-D-I-S-K-F-N-A-L-F-E-D-V-E-Q-F-L-N-I


### FUNCTION Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner ### SEQUENCE -M-A-I-T-K-I-N-D-C-F-E-L-L-S-M-V-T-Y-A-D-K-L-K-S-L-I-K-K-E-F-S-I-S-F-E-E-F-A-V-L-T-Y-I-S-E-N-K-E-K-E-Y-Y-L-K-D-I-I-N-H-L-N-Y-K-Q-P-Q-V-V-K-A-V-K-I-L-S-Q-E-D-Y-F-D-K-K-R-N-E-H-D-E-R-T-V-L-I-L-V-N-A-Q-Q-R-K-K-I-E-S-L-L-S-R-V-N-K-R-I-T-E-A-N-N-E-I-E-L


### FUNCTION Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines Requires NADPH, but not NADH, as an electron donor for its activity ### SEQUENCE -M-K-G-L-I-I-I-G-S-A-Q-V-N-S-H-T-S-A-L-A-R-Y-L-T-E-H-F-K-T-H-D-I-E-A-E-I-F-D-L-A-E-K-P-L-N-Q-L-D-F-S-G-T-T-P-S-I-D-E-I-K-Q-N-M-K-D-L-K-E-K-A-M-A-A-D-F-L-I-L-G-T-P-N-Y-H-G-S-Y-S-G-I-L-K-N-A-L-D-H-L-N-M-D-Y-F-K-M-K-P-V-G-L-I-G-N-S-G-G-I-V-S-S-E-P-L-S-H-L-R-V-I-V-R-S-L-L-G-I-A-V-P-T-Q-I-A-T-H-D-S-D-F-A-K-N-E-D-G-S-Y-Y-L-N-D-S-E-F-Q-L-R-A-R-L-F-V-D-Q-I-V-S-F-V-N-N-S-P-Y-E-H-L-K


### FUNCTION Could be involved in septation ### SEQUENCE -M-K-V-T-D-V-R-L-R-K-I-Q-T-D-G-R-M-K-A-L-V-S-I-T-L-D-E-A-F-V-I-H-D-L-R-V-I-E-G-N-S-G-L-F-V-A-M-P-S-K-R-T-P-D-G-E-F-R-D-I-A-H-P-I-N-S-D-M-R-Q-E-I-Q-D-A-V-M-K-V-Y-D-E-T-D-E-V-V-P-D-K-N-A-T-S-E-D-S-E-E-A


### FUNCTION Involved in initiation control of chromosome replication ### SEQUENCE -M-D-R-N-E-I-F-E-K-I-M-R-L-E-M-N-V-N-Q-L-S-K-E-T-S-E-L-K-A-H-A-V-E-L-V-E-E-N-V-A-L-Q-L-E-N-D-N-L-K-K-V-L-G-N-D-E-P-T-T-I-D-T-A-N-S-K-P-A-K-A-V-K-K-P-L-P-S-K-D-N-L-A-I-L-Y-G-E-G-F-H-I-C-K-G-E-L-F-G-K-H-R-H-G-E-D-C-L-F-C-L-E-V-L-S-D


### FUNCTION Virulence factor that is important for the establishment of infection in the host EsxB is required for EsxA synthesis as well as secretion ### SEQUENCE -M-G-G-Y-K-G-I-K-A-D-G-G-K-V-N-Q-A-K-Q-L-A-A-K-I-A-K-D-I-E-A-C-Q-K-Q-T-Q-Q-L-A-E-Y-I-E-G-S-D-W-E-G-Q-F-A-N-K-V-K-D-V-L-L-I-M-A-K-F-Q-E-E-L-V-Q-P-M-A-D-H-Q-K-A-I-D-N-L-S-Q-N-L-A-K-Y-D-T-L-S-I-K-Q-G-L-D-R-V-N-P


### FUNCTION Component of the ESAT-6 secretion system  Required for the secretion of EsxA and EsxB ### SEQUENCE -M-L-M-N-S-V-I-A-L-T-F-L-T-A-S-S-N-N-G-G-L-N-I-D-V-Q-Q-E-E-E-K-R-I-N-N-D-L-N-Q-Y-D-T-T-L-F-N-K-D-S-K-E-V-N-D-A-I-A-K-Q-K-K-E-R-Q-Q-Q-I-K-N-D-M-F-Q-N-Q-A-S-H-S-T-R-L-N-E-T-K-K-V-L-F-S-K-S-N-L-E-K-T-S-E-S-D-K-S-P-Y-I-Q-N-K-Q-E-K-K-I-F-P-Y-I-L-M-S-V-G-A-F-L-T-L-G-F-V-I-F-S-I-H-K-G-R-R-T-K-N-E-S-A-R-K-S-N-I


### FUNCTION Virulence factor that is important for the establishment of infection in the host EsxA is required for EsxB synthesis as well as secretion ### SEQUENCE -M-A-M-I-K-M-S-P-E-E-I-R-A-K-S-Q-S-Y-G-Q-G-S-D-Q-I-R-Q-I-L-S-D-L-T-R-A-Q-G-E-I-A-A-N-W-E-G-Q-A-F-S-R-F-E-E-Q-F-Q-Q-L-S-P-K-V-E-K-F-A-Q-L-L-E-E-I-K-Q-Q-L-N-S-T-A-D-A-V-Q-E-Q-D-Q-Q-L-S-N-N-F-G-L-Q


### FUNCTION Binding protein with a strong affinity to the bleomycin family of antibiotics, which confers resistance to these antibiotics by preventing the bleomycin-induced DNA breakage ### SEQUENCE -M-L-Q-S-I-P-A-L-P-V-G-D-I-K-K-S-I-G-F-Y-C-D-K-L-G-F-T-L-V-H-H-E-D-G-F-A-V-L-M-C-N-E-V-R-I-H-L-W-E-A-S-D-E-G-W-R-S-R-S-N-D-S-P-V-C-T-G-A-E-S-F-I-A-G-T-A-S-C-R-I-E-V-E-G-I-D-E-L-Y-Q-H-I-K-P-L-G-I-L-H-P-N-T-S-L-K-D-Q-W-W-D-E-R-D-F-A-V-I-D-P-D-N-N-L-I-S-F-F-Q-Q-I-K-S


### FUNCTION Involved in the temperature-dependent positive control of flagellum-driven swimming motility and cellular aggregation Regulates fliC expression by directly interacting with fliC promoter ### SEQUENCE -M-T-L-R-N-K-A-F-H-Q-L-R-Q-L-F-Q-Q-H-T-A-R-W-Q-H-E-L-P-D-L-T-K-P-Q-Y-A-V-M-R-A-I-A-D-K-P-G-I-E-Q-V-A-L-I-E-A-A-V-S-T-K-A-T-L-A-E-M-L-A-R-M-E-N-R-G-L-V-R-R-E-H-D-A-A-D-K-R-R-R-F-V-W-L-T-A-E-G-E-K-I-L-A-A-A-I-P-I-G-D-S-V-D-E-E-F-L-G-R-L-S-A-E-E-Q-E-L-F-V-Q-L-V-R-K-M-M-N-T


### FUNCTION Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ ### SEQUENCE -M-S-S-K-E-Q-K-T-P-E-G-Q-A-P-E-E-I-I-M-D-Q-H-E-E-I-E-A-V-E-P-E-A-S-A-E-Q-V-D-P-R-D-E-K-I-A-N-L-E-A-Q-L-A-E-A-Q-T-R-E-R-D-G-I-L-R-V-K-A-E-M-E-N-L-R-R-R-T-E-L-D-I-E-K-A-H-K-F-A-L-E-K-F-I-N-E-L-L-P-V-I-D-S-L-D-R-A-L-E-V-A-D-K-A-N-P-D-M-S-A-M-V-E-G-I-E-L-T-L-K-S-M-L-D-V-V-R-K-F-G-V-E-V-I-A-E-T-N-V-P-L-D-P-N-V-H-Q-A-I-A-M-V-E-S-D-D-V-A-P-G-N-V-L-G-I-M-Q-K-G-Y-T-L-N-G-R-T-I-R-A-A-M-V-T-V-A-K-A-K-A


### FUNCTION Participates in cysteine desulfuration mediated by SufS Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process ### SEQUENCE -M-A-L-L-P-D-K-E-K-L-L-R-N-F-L-R-C-A-N-W-E-E-K-Y-L-Y-I-I-E-L-G-Q-R-L-P-E-L-R-D-E-D-R-S-P-Q-N-S-I-Q-G-C-Q-S-Q-V-W-I-V-M-R-Q-N-A-Q-G-I-I-E-L-Q-G-D-S-D-A-A-I-V-K-G-L-I-A-V-V-F-I-L-Y-D-Q-M-T-P-Q-D-V-V-N-F-D-V-R-P-W-F-E-K-M-A-L-T-Q-H-L-T-P-S-R-S-Q-G-L-E-A-M-I-R-A-I-R-A-K-A-A-A-L-S


### FUNCTION Broad mercury transporter that mediates the transport of both CH across the membrane ### SEQUENCE -M-N-A-P-D-K-L-P-P-E-T-R-Q-P-V-S-G-Y-L-W-G-A-L-A-V-L-T-C-P-C-H-L-P-I-L-A-A-V-L-A-G-T-T-A-G-A-F-L-G-E-H-W-G-V-A-A-L-A-L-T-G-L-F-V-L-A-V-T-R-L-L-R-A-F-R-G-G-S


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-A-S-E-V-T-S-A-K-A-V-A-K-T-V-R-I-A-P-R-K-A-R-I-V-I-D-L-I-R-G-K-Q-V-G-E-A-I-A-I-L-K-Y-T-P-R-S-A-S-P-I-I-E-K-V-L-K-S-A-I-A-N-A-E-H-N-Y-D-L-D-I-N-N-L-V-V-E-E-A-F-V-D-E-G-P-T-L-K-R-F-R-P-R-A-Q-G-R-A-S-A-I-N-K-R-T-S-H-I-T-V-V-V-S-E-V-K-E-G


### FUNCTION Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs ### SEQUENCE -M-L-V-P-K-R-V-K-Y-R-R-E-F-R-G-N-M-R-G-R-A-K-G-G-T-E-V-A-F-G-E-Y-G-L-Q-A-V-E-A-S-W-I-T-N-R-Q-I-E-A-A-R-I-A-M-T-R-Y-M-K-R-G-G-K-V-W-I-K-I-F-P-H-K-S-Y-T-S-K-P-I-G-V-R-M-G-K-G-K-G-A-P-E-G-W-V-S-P-V-K-R-G-K-I-M-F-E-I-A-G-V-P-E-D-V-A-R-E-A-L-R-L-A-A-H-K-L-P-V-K-T-K-I-V-K-R-E-E-I-G-G-E-A-N-E-S


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-A-D-R-N-Q-R-K-V-Y-T-G-R-V-V-S-D-K-M-D-K-T-I-T-V-V-V-E-T-Y-K-K-H-G-L-Y-G-K-R-V-K-Y-S-K-K-F-K-A-H-D-E-N-N-I-A-K-T-G-D-V-V-R-I-S-E-T-R-P-L-S-A-T-K-H-F-R-L-L-E-V-V-E-E-A-V-I-I


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-Q-E-S-R-M-K-V-A-D-N-S-G-A-R-E-V-L-T-I-K-V-L-G-G-S-G-R-K-T-A-N-I-G-D-V-V-V-C-T-V-K-Q-A-T-P-G-G-V-V-K-K-G-E-V-V-K-A-V-I-V-R-T-K-S-G-A-R-R-Q-D-G-S-Y-I-K-F-D-E-N-A-C-V-I-I-R-D-D-K-S-P-R-G-T-R-I-F-G-P-V-A-R-E-L-R-E-N-N-F-M-K-I-V-S-L-A-P-E-V-L


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-N-R-L-K-D-Q-Y-L-K-E-I-V-P-A-L-M-S-K-F-N-Y-D-S-V-M-E-V-P-K-I-D-K-I-V-I-N-T-G-V-G-D-A-T-A-N-A-K-V-L-D-S-A-V-E-E-L-A-L-I-T-G-Q-K-P-V-I-T-K-A-K-N-S-I-A-G-F-R-L-R-E-G-M-P-I-G-A-K-V-T-L-R-G-E-R-M-Y-D-F-L-D-K-L-V-T-V-S-L-P-R-V-R-D-F-R-G-V-S-K-K-A-F-D-G-R-G-N-Y-T-L-G-V-R-E-Q-L-I-F-P-E-I-D-Y-D-Q-V-S-K-V-R-G-M-D-V-V-I-V-T-T-A-K-S-D-E-E-S-H-E-L-L-T-Q-L-G-M-P-F-Q-K


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA ### SEQUENCE -M-A-L-T-Q-E-R-K-N-E-I-I-A-E-Y-R-V-H-D-T-D-T-G-S-P-E-V-Q-I-A-V-L-T-A-E-I-N-S-L-N-E-H-V-R-V-H-K-K-D-H-H-S-Y-R-G-L-M-K-M-V-G-H-R-R-N-L-L-T-Y-L-R-K-K-D-V-Q-R-Y-R-E-L-I-K-R-L-G-L-R-R


### FUNCTION A non-essential component of RNA polymerase ### SEQUENCE -M-I-F-K-V-F-Y-Q-E-T-L-T-E-T-P-V-R-E-K-T-Q-S-L-Y-V-E-A-E-S-E-V-K-V-R-Q-L-L-K-D-E-P-F-H-I-E-F-V-E-K-I-S-D-A-H-L-A-Y-E-K-E-N-P-D-F-A-L-W-E-K


### FUNCTION Essential subunit of the Sec protein translocation channel SecYEG Clamps together the 2 halves of SecY May contact the channel plug during translocation ### SEQUENCE -M-F-K-E-Y-K-I-Y-K-F-F-E-Q-V-K-Q-E-T-Y-K-V-V-W-P-T-R-K-E-L-V-A-S-T-L-V-V-V-V-A-V-F-I-F-S-L-I-C-L-V-L-D-Y-S-I-H-N-I-M-Q-L-L-L-N-I-G-K


### FUNCTION Lanthionine-containing peptide devoid of antibiotic properties, involved in the formation of aerial mycelium Suggested to self-assemble at air-water interfaces, thus providing a film of surfactant through which nascent aerial hyphae can emerge The aerial hyphae differentiate further into spores ### SEQUENCE -M-N-L-F-D-L-Q-S-M-E-T-P-K-E-E-A-M-G-D-V-E-T-G-S-R-A-S-L-L-L-C-G-D-S-S-L-S-I-T-T-C-N


### FUNCTION Involved in UV protection and mutation ### SEQUENCE -M-S-T-V-Y-H-R-P-A-D-P-S-G-D-D-S-Y-V-R-P-L-F-A-D-R-C-Q-A-G-F-P-S-P-A-T-D-Y-A-E-Q-E-L-D-L-N-S-Y-C-I-S-R-P-A-A-T-F-F-L-R-A-S-G-E-S-M-N-Q-A-G-V-Q-N-G-D-L-L-V-V-D-R-A-E-K-P-Q-H-G-D-I-V-I-A-E-I-D-G-E-F-T-V-K-R-L-L-L-R-P-R-P-A-L-E-P-V-S-D-S-P-E-F-R-T-L-Y-P-E-N-I-C-I-F-G-V-V-T-H-V-I-H-R-T-R-E-L-R


### FUNCTION This protein is involved in the determination of copy number in gene replication It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA ### SEQUENCE -M-S-Q-T-E-N-A-V-T-S-S-S-G-A-K-R-A-Y-R-K-G-N-P-L-S-D-A-E-K-Q-R-L-S-V-A-R-K-R-A-S-F-K-E-V-K-V-F-L-E-P-K-Y-K-A-M-L-M-Q-M-C-H-E-D-G-L-T-Q-A-E-V-L-T-A-L-I-K-S-E-A-Q-K-R-C-V


### FUNCTION Participates in cysteine desulfuration mediated by SufS Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process ### SEQUENCE -M-A-L-L-P-D-K-E-K-L-L-R-N-F-L-R-C-A-N-W-E-E-K-Y-L-Y-I-I-E-L-G-Q-R-L-P-E-L-R-A-E-D-G-S-P-Q-N-S-I-Q-G-C-Q-S-Q-V-W-I-V-M-R-Q-N-A-Q-G-I-I-E-L-Q-G-D-S-D-A-A-I-V-K-G-L-I-A-V-V-F-I-L-Y-D-Q-M-T-P-Q-D-I-V-N-F-D-V-R-P-W-F-E-K-M-A-L-T-Q-H-L-T-P-S-R-S-Q-G-L-E-A-M-I-R-A-I-R-A-K-A-A-A-L-S


### FUNCTION The VirB system could be required for the establishment of the replication niche in the host ### SEQUENCE -M-K-T-A-S-P-S-K-K-S-L-S-R-I-L-P-H-L-L-L-A-L-I-V-S-I-A-A-I-E-P-N-L-A-H-A-N-G-G-L-D-K-V-N-T-S-M-Q-K-V-L-D-L-L-S-G-V-S-I-T-I-V-T-I-A-I-I-W-S-G-Y-K-M-A-F-R-H-A-R-F-M-D-V-V-P-V-L-G-G-A-L-V-V-G-A-A-A-E-I-A-S-Y-L-L-R


### FUNCTION The VirB system could be required for the establishment of the replication niche in the host ### SEQUENCE -M-T-T-A-P-Q-E-S-N-A-R-S-A-G-Y-R-G-D-P-I-F-K-G-C-T-R-P-A-M-L-F-G-V-P-V-I-P-L-V-I-V-G-G-S-I-V-L-L-S-V-W-I-S-M-F-I-L-P-L-I-V-P-I-V-L-V-M-R-Q-I-T-Q-T-D-D-Q-M-F-R-L-L-G-L-K-A-Q-F-R-L-I-H-F-N-R-T-G-R-F-W-R-A-S-A-Y-S-P-I-A-F-T-K-R-K-R-E-S


### FUNCTION The VirB system could be required for the establishment of the replication niche in the host ### SEQUENCE -M-K-K-V-I-L-A-F-V-A-T-A-F-L-A-G-C-T-T-T-G-P-A-V-V-P-V-L-D-G-K-P-R-V-P-V-N-K-S-V-P-A-K-P-P-L-A-Q-P-N-P-V-D-T-Y-E-D


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-N-L-N-A-T-I-L-G-Q-A-I-A-F-V-L-F-V-I-F-C-M-K-Y-V-W-P-P-I-M-A-A-I-E-K-R-Q-Q-E-I-A-D-G-L-S-S-A-E-R-A-K-K-D-L-D-L-A-Q-A-N-A-T-D-Q-L-K-K-A-K-A-E-A-Q-V-I-I-E-Q-A-S-K-R-K-A-Q-I-L-D-E-A-K-A-E-A-E-Q-E-R-N-K-I-V-A-Q-A-Q-A-E-I-D-A-E-R-K-R-A-R-E-E-L-R-K-Q-V-A-M-L-A-I-A-G-A-E-K-I-I-E-R-S-V-D-E-A-A-N-S-D-I-V-D-K-L-V-A-E-L


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-S-E-F-V-T-V-A-R-P-Y-A-K-A-A-F-D-F-A-V-E-H-Q-A-V-E-R-W-Q-N-M-L-A-F-T-A-Q-V-T-R-N-E-Q-I-A-E-L-L-S-G-A-V-A-P-E-T-M-S-T-T-F-I-A-V-C-G-D-Q-L-D-E-P-A-Q-N-F-I-R-V-M-A-E-N-G-R-L-L-V-L-P-E-V-L-Q-Q-F-I-Q-L-R-A-S-L-E-S-T-V-D-V-E-V-S-S-A-R-A-L-N-D-E-Q-L-A-K-I-A-A-A-M-E-K-R-L-S-R-K-V-K-L-N-C-K-I-D-K-S-V-M-A-G-V-V-I-R-A-G-D-M-V-I-D-G-S-V-R-G-R-L-E-R-L-A-D-V-L-Q-S


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-S-R-V-A-K-A-P-V-V-I-P-A-G-V-E-V-K-L-N-G-Q-V-I-S-I-K-G-K-N-G-E-L-T-R-T-V-H-S-A-V-E-V-K-Q-E-E-N-T-L-T-F-A-P-R-E-G-A-V-D-G-W-A-Q-A-G-T-T-R-A-L-L-N-S-M-V-I-G-V-T-E-G-F-T-K-K-L-Q-L-V-G-V-G-Y-R-A-A-V-K-G-N-V-V-N-L-A-L-G-F-S-H-P-V-D-H-E-L-P-A-G-I-T-A-E-C-P-T-Q-T-E-I-V-L-K-G-A-D-K-Q-V-I-G-Q-V-A-A-D-L-R-A-Y-R-R-P-E-P-Y-K-G-K-G-V-R-Y-A-D-E-V-V-R-T-K-E-A-K-K-K


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-E-Q-T-M-L-N-V-A-D-N-S-G-A-R-R-V-M-C-I-K-V-L-G-G-S-H-R-R-Y-A-G-I-G-D-I-I-K-I-T-I-K-E-A-I-P-R-G-K-V-K-K-G-D-V-L-K-A-V-V-V-R-T-K-K-G-V-R-R-P-D-G-S-V-I-R-F-D-G-N-A-C-V-I-L-N-N-N-S-E-Q-P-I-G-T-R-I-F-G-P-V-T-R-E-L-R-N-E-K-F-M-K-I-I-S-L-A-P-E-V-L


### FUNCTION May function as a transcriptional regulator that controls feoABC expression ### SEQUENCE -M-A-S-L-L-Q-L-R-D-A-I-A-L-N-G-S-A-E-A-S-Q-L-S-R-Q-L-A-I-P-L-P-L-V-N-A-M-L-E-K-L-T-A-M-G-K-I-E-R-I-E-L-D-H-S-G-C-L-T-G-S-C-K-S-C-P-E-G-H-Q-H-C-N-T-V-I-Y-Q-L-K-E-P-H-A-H-Q


### FUNCTION Essential cell division protein May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ### SEQUENCE -M-I-G-N-E-R-H-G-L-V-G-V-I-G-A-D-L-I-R-N-A-K-I-P-L-I-L-L-V-A-V-L-I-S-A-V-L-V-V-T-T-A-H-R-T-R-L-L-T-A-E-R-E-Q-L-V-L-E-R-D-A-L-D-I-E-W-R-N-L-I-L-E-E-N-A-L-G-D-H-S-R-V-E-S-I-A-I-E-K-L-K-M-Q-H-V-D-P-S-Q-E-N-I-V-I-K


### FUNCTION Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ### SEQUENCE -M-I-T-M-R-C-K-M-L-T-A-A-A-V-M-L-A-M-L-T-A-G-C-S-T-L-E-K-V-V-Y-R-P-D-I-N-Q-G-N-Y-L-S-P-I-D-A-S-K-I-H-K-G-M-T-Q-Q-Q-V-A-Y-T-L-G-T-P-M-L-Q-D-P-F-G-T-Q-T-W-F-Y-V-F-R-Q-Q-P-G-H-E-K-I-T-Q-Q-T-L-T-L-T-F-D-S-S-G-V-L-T-D-I-K-N-E-P-A-L-T-G-S


### FUNCTION Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ ### SEQUENCE -M-S-S-K-E-Q-K-T-P-N-E-Q-V-S-E-E-M-E-N-T-A-E-Q-Q-V-E-A-T-Q-E-T-G-E-C-V-D-P-R-V-A-E-L-E-V-Q-L-S-D-A-L-Q-R-E-R-E-S-L-L-R-A-K-A-E-V-E-N-I-R-R-R-T-E-L-D-V-E-K-A-H-K-F-A-L-E-R-F-S-S-E-L-L-P-V-I-D-N-L-E-R-A-L-D-T-A-D-K-T-N-T-E-L-I-S-M-I-E-G-V-E-L-T-L-K-S-L-L-D-A-V-G-K-F-G-I-E-V-V-G-E-T-H-V-P-F-N-P-E-V-H-Q-A-M-T-M-L-E-S-A-D-H-E-P-N-H-V-M-M-V-M-Q-K-G-Y-T-L-N-G-R-L-L-R-P-A-M-V-A-V-S-K-A-K-S


### FUNCTION Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ ### SEQUENCE -M-R-I-K-P-D-D-K-W-R-W-Y-F-D-T-E-H-D-R-L-M-L-D-L-A-N-G-M-I-F-R-S-R-F-P-S-K-M-L-T-P-D-A-F-D-E-S-A-F-C-V-D-D-A-A-L-Y-F-E-F-E-D-Q-C-R-Q-I-K-L-S-N-E-Q-R-S-E-L-V-L-N-A-L-V-A-C-R-F-L-K-P-L-M-P-K-S-W-H-F-V-Q-Q-P-K-V-L-I-P-Q-N-G-E-L-T-L-V-T-V-L-D-N-G-E-N-V-R-L-L-V-V-E-P-S-C-S-A-S-L-C-L-L-A-Q-S-Q-V-V-L-A-G-R-Q-L-V-L-G-D-A-I-K-I-M-N-N-R-L-L-P-L-M-V-E-E-V-N-T-T-T-A-Y-D-R-A-V


### FUNCTION Component of the SOS system and an inhibitor of cell division Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments In the presence of GTP, binds a polymerization-competent form of FtsZ in a 11 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division ### SEQUENCE -M-R-T-Q-S-L-K-P-Y-H-A-N-Y-H-S-L-T-T-N-D-S-P-T-R-V-D-A-P-T-D-S-G-L-I-S-E-F-V-Y-S-E-N-Q-P-V-V-T-Q-L-L-L-P-L-L-Q-Q-L-S-K-Q-S-R-W-L-L-W-L-T-P-Q-Q-K-L-S-R-S-W-L-K-Q-S-G-L-P-I-N-K-V-V-Q-L-R-Q-I-N-P-L-S-T-V-E-A-M-E-K-A-L-L-T-G-N-Y-S-V-V-L-G-W-L-P-E-L-T-E-D-D-R-I-R-L-R-L-A-A-K-L-G-N-A-Y-G-F-V-M-R-P-L-N-D-T-K-V-G-S-G-Q-C-A-T-L-K-I-H-S-Y-L-Y-H


### FUNCTION Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress ### SEQUENCE -M-I-A-S-K-F-G-I-G-Q-Q-V-R-H-S-L-H-G-Y-L-G-V-V-I-D-I-D-P-E-Y-S-L-A-P-P-E-P-D-E-V-A-N-N-K-T-L-R-S-S-P-W-Y-H-V-V-I-E-D-D-D-G-Q-P-V-H-T-Y-L-A-E-A-Q-L-T-Y-E-D-V-D-A-H-P-E-Q-P-S-L-D-E-L-A-A-S-I-R-H-Q-L-Q-A-P-H-L-R-N


### FUNCTION Probably mediates the hydrolysis of some nucleoside diphosphate derivatives ### SEQUENCE -M-S-E-L-I-T-G-Q-Y-L-S-E-F-I-N-R-F-Q-L-Q-L-P-Q-P-D-N-V-L-T-H-S-H-Y-F-S-A-T-N-R-R-A-A-V-L-I-P-I-I-C-R-P-E-P-T-L-L-L-T-R-R-A-D-H-L-R-K-H-A-G-Q-V-A-F-P-G-G-K-A-D-P-D-D-Q-S-L-I-S-T-A-L-R-E-A-E-E-E-V-A-I-P-A-S-V-V-H-V-L-G-K-L-A-P-L-N-S-S-S-G-Y-H-V-T-P-I-V-G-L-V-P-A-N-I-P-F-Y-G-N-D-E-E-V-A-G-L-F-E-I-P-L-H-E-A-L-S-L-S-R-Y-H-S-L-D-I-H-R-E-G-I-N-H-R-V-Y-L-S-W-Y-E-N-Q-F-I-W-G-L-T-A-T-I-I-R-H-L-A-Q-Q-V-S-I


### FUNCTION Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B ### SEQUENCE -M-K-R-Y-L-S-L-A-L-A-A-L-V-L-T-G-C-V-P-P-D-S-V-T-P-T-P-P-V-T-I-E-P-V-T-P-P-D-V-E-V-P-P-P-V-D-T-V-P-Q-P-P-K-V-Q-S-I-D-W-A-V-S-V-E-P-L-V-A-Q-M-V-N-S-D-E-V-A-T-G-S-I-L-L-V-D-S-V-K-N-N-T-N-G-A-L-Q-T-A-K-A-T-A-A-L-H-Q-V-L-S-S-N-K-K-F-V-L-I-S-P-Q-Q-L-G-V-A-K-Q-T-L-G-L-S-E-E-D-S-F-G-S-R-S-K-A-I-G-L-A-R-Y-V-G-A-Q-Y-V-L-Y-S-D-V-S-G-D-V-K-S-P-T-I-E-M-Q-L-M-Q-T-Q-T-G-E-I-I-W-S-G-N-A-P-V-Q-Y


### FUNCTION Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 ### SEQUENCE -M-T-L-T-S-A-H-P-K-S-K-L-M-K-R-F-A-A-L-G-P-Y-L-R-E-G-Q-C-Q-N-D-H-F-F-F-D-C-L-A-V-C-I-N-V-K-L-A-P-E-K-R-E-F-W-G-W-W-I-E-L-E-P-S-A-G-R-F-T-Y-V-Y-Q-L-G-L-F-N-K-E-G-N-W-N-A-E-K-I-S-D-P-E-V-Q-D-K-L-E-S-T-L-R-S-F-H-L-R-L-E-E-M-L-A-S-I-D-M-K-L-E-P-A-A-D-F-N-D-Q-P-V-K-L-S-A


### FUNCTION Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase ### SEQUENCE -M-L-N-R-L-E-S-L-T-Q-R-V-G-G-S-N-E-L-I-D-Q-W-L-H-A-R-K-E-L-L-V-S-Y-C-T-V-I-G-I-K-P-Q-K-E-K-H-T-P-L-N-A-K-T-L-E-N-F-C-H-N-L-V-D-Y-L-S-S-G-H-F-H-L-Y-D-R-I-I-K-E-V-E-G-A-S-S-P-K-M-A-L-T-A-K-I-H-P-A-L-K-N-N-T-Q-T-I-M-A-F-H-D-C-Y-T-N-I-E-I-D-D-D-S-C-T-E-Y-Q-Q-A-L-S-D-I-G-E-A-L-D-A-R-F-R-L-E-D-Q-L-I-Q-W-A-A-E-S-W-Q-A-A-Q-L-A-D-A-D-K-K-S-Q-V-N


### FUNCTION Non-essential, abundant cell division factor that is required for proper Z-ring formation It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle Its recruitment to the Z-ring requires functional FtsA or ZipA ### SEQUENCE -M-S-F-E-V-F-E-K-L-E-V-K-V-Q-Q-A-I-D-T-I-T-L-L-Q-M-E-I-E-E-L-K-E-K-N-N-T-L-T-Q-E-V-Q-D-A-A-G-S-R-E-A-L-V-R-E-N-E-Q-L-K-Q-E-Q-H-V-W-Q-D-R-L-R-A-L-L-G-K-M-E-E-V


### FUNCTION Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site ### SEQUENCE -M-A-K-T-S-M-I-H-R-D-I-K-R-A-K-L-A-K-K-F-A-G-K-R-D-A-L-K-K-I-L-S-S-Q-D-A-S-Y-E-E-K-I-D-A-S-T-K-L-Q-K-L-P-R-D-S-S-P-S-R-H-R-N-R-C-E-L-S-G-R-P-R-G-V-Y-R-K-F-G-L-G-R-N-M-L-R-K-A-T-M-N-G-D-V-P-G-L-R-K-A-S-W


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-M-Q-S-Y-L-D-V-A-D-N-S-G-A-K-E-V-M-C-I-K-V-L-G-G-S-K-R-R-Y-A-H-I-G-D-I-I-K-V-T-V-K-D-A-I-P-R-G-K-V-K-K-G-E-V-Y-D-A-V-V-V-R-T-R-K-G-V-R-R-P-D-G-S-L-I-R-F-D-G-N-A-A-V-L-L-N-N-K-Q-E-P-I-G-T-R-I-F-G-P-V-T-R-E-L-R-S-E-K-F-M-K-I-V-S-L-A-P-E-V-L


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-T-M-E-A-K-A-I-L-R-T-A-R-I-S-P-Q-K-A-R-L-V-A-D-Q-V-R-G-L-S-A-E-R-A-V-N-L-L-K-F-S-D-K-K-A-A-H-L-I-K-K-V-V-E-S-A-I-A-N-A-E-N-N-Q-G-A-D-V-D-E-L-K-V-K-T-I-M-V-D-E-G-P-S-L-K-R-F-M-A-R-A-K-G-R-G-T-R-I-L-K-R-T-S-H-I-T-V-V-V-G-A-A-K


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-T-T-F-T-A-K-S-E-T-V-Q-R-D-W-Y-L-V-D-A-A-G-K-T-L-G-R-L-S-T-E-L-A-R-R-L-R-G-K-H-K-P-V-Y-T-P-H-V-D-T-G-D-Y-L-V-V-I-N-A-E-K-I-V-V-T-G-N-K-L-K-D-K-K-Y-H-R-F-T-G-Y-I-G-N-L-K-T-E-S-L-E-Q-A-L-Q-R-H-P-E-R-V-I-E-I-A-V-K-G-M-L-P-K-G-P-L-G-R-T-M-Y-R-K-L-K-V-Y-S-G-A-E-H-P-H-A-A-Q-Q-P-Q-V-L-D-I


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA ### SEQUENCE -M-A-I-S-K-E-K-K-N-E-I-I-A-Q-Y-A-R-H-E-G-D-T-G-S-V-E-V-Q-V-A-V-L-T-W-E-I-N-H-L-N-S-H-I-K-E-H-K-K-D-H-A-T-Y-R-G-L-M-K-K-I-G-H-R-R-N-L-L-A-Y-L-R-R-T-D-V-N-R-Y-R-E-L-I-Q-S-L-G-L-R-R


### FUNCTION A non-essential component of RNA polymerase ### SEQUENCE -M-I-Y-K-V-F-Y-Q-E-T-K-D-Q-S-P-R-R-E-S-T-K-A-L-Y-L-N-I-D-A-T-D-E-L-D-G-R-I-K-A-R-R-L-V-E-D-N-T-Y-Y-N-V-E-F-I-E-L-L-S-D-K-H-L-D-Y-E-K-E-T-G-V-F-E-L-T-E-F


### FUNCTION Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed Also contributes to the recruitment of PBP1 to the division complex Not essential for septum formation ### SEQUENCE -M-T-S-I-I-Y-S-P-K-D-I-F-E-Q-E-F-K-T-S-M-R-G-F-D-K-K-E-V-D-E-F-L-D-N-V-I-K-D-Y-E-N-F-N-A-Q-I-E-A-L-K-A-E-N-E-A-L-K-K-A-K-F-Q-A-R-N-T-V-S-A-T-V-Q-Q-P-V-P-Q-P-T-R-V-A-Q-S-A-T-N-F-D-I-L-K-R-I-S-K-L-E-K-E-V-F-G-K-Q-I-I-E


### FUNCTION Regulates the transcription of the arc operon, involved in arginine catabolism ### SEQUENCE -M-N-K-K-E-T-R-H-Q-L-I-R-S-L-I-S-E-T-T-I-H-T-Q-Q-E-L-Q-E-R-L-Q-K-N-G-I-T-I-T-Q-A-T-L-S-R-D-M-K-E-L-N-L-V-K-V-T-S-G-N-D-T-H-Y-E-A-L-A-I-S-Q-T-R-W-E-H-R-L-R-F-Y-M-E-D-A-L-V-M-L-K-I-V-Q-H-Q-I-I-L-K-T-L-P-G-L-A-Q-S-F-G-S-I-L-D-A-M-Q-I-P-E-I-V-A-T-V-C-G-D-D-T-C-L-I-V-C-E-D-N-E-Q-A-K-A-C-Y-E-T-L-S-H-Y-T-P-P-F-F-F-S-N-K


### FUNCTION This protein binds to 23S rRNA in the presence of protein L20 ### SEQUENCE -M-S-T-Y-A-I-I-K-T-G-G-K-Q-V-K-V-E-V-G-Q-A-I-Y-V-E-K-I-D-A-E-A-G-A-E-V-T-F-N-E-V-V-L-V-G-G-D-K-T-V-V-G-T-P-V-V-E-G-A-T-V-V-G-T-V-E-K-Q-G-K-Q-K-K-V-V-T-F-K-Y-K-P-K-K-G-S-H-R-K-Q-G-H-R-Q-P-Y-T-K-V-V-I-N-A-I-N-A


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-K-L-H-E-L-K-A-A-E-G-S-R-K-V-R-N-R-V-G-R-G-T-S-S-G-N-G-K-T-S-G-R-G-Q-K-G-Q-K-A-R-S-G-G-G-V-R-L-G-F-E-G-G-Q-T-P-L-F-R-R-I-P-K-R-G-F-T-N-I-N-T-K-E-Y-A-L-V-N-L-D-Q-L-N-V-F-D-D-G-T-E-V-T-P-A-I-L-K-D-A-G-I-V-R-A-E-K-S-G-V-K-V-L-G-N-G-E-L-T-K-K-L-T-V-K-A-A-K-F-S-K-S-A-E-A-A-I-I-A-K-G-G-S-I-E-V-I


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-I-S-K-P-D-K-N-K-I-R-Q-K-R-H-R-R-V-R-G-K-L-S-G-T-A-D-R-P-R-L-N-V-F-R-S-N-T-G-I-Y-A-Q-V-I-D-D-V-A-G-V-T-L-A-S-A-S-T-L-D-K-D-V-S-K-G-T-K-T-E-Q-A-V-V-V-G-K-L-V-A-E-R-A-V-A-K-G-I-S-E-V-V-F-D-R-G-G-Y-L-Y-H-G-R-V-K-A-L-A-D-A-A-R-E-N-G-L-K-F


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-S-R-I-G-N-K-V-I-T-M-P-A-G-V-E-L-T-N-N-N-N-V-I-T-V-K-G-P-K-G-E-L-T-R-E-F-N-K-N-I-E-I-K-V-E-G-T-E-I-T-V-V-R-P-N-D-S-K-E-M-K-T-I-H-G-T-T-R-A-N-L-N-N-M-V-V-G-V-S-E-G-F-K-K-D-L-E-M-K-G-V-G-Y-R-A-Q-L-Q-G-T-K-L-V-L-S-V-G-K-S-H-Q-D-E-V-E-A-P-E-G-I-T-F-T-V-A-N-P-T-S-I-S-V-E-G-I-N-K-E-V-V-G-Q-T-A-A-Y-I-R-S-L-R-S-P-E-P-Y-K-G-K-G-I-R-Y-V-G-E-Y-V-R-L-K-E-G-K-T-G-K


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-A-N-R-L-K-E-K-Y-T-N-E-V-I-P-A-L-T-E-K-F-N-Y-T-S-V-M-A-V-P-K-V-E-K-I-V-L-N-M-G-V-G-D-A-V-S-N-A-K-N-L-E-K-A-A-A-E-L-A-L-I-S-G-Q-K-P-L-I-T-K-A-K-K-S-I-A-G-F-R-L-R-E-G-V-A-I-G-A-K-V-T-L-R-G-E-R-M-Y-E-F-L-D-K-L-V-S-V-S-L-P-R-V-R-D-F-H-G-V-P-T-K-S-F-D-G-R-G-N-Y-T-L-G-V-K-E-Q-L-I-F-P-E-I-S-F-D-D-V-D-K-V-R-G-L-D-I-V-I-V-T-T-A-N-T-D-E-E-S-R-E-L-L-K-G-L-G-M-P-F-A-K


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-Q-E-T-R-L-K-V-A-D-N-S-G-A-R-E-I-L-T-I-K-V-L-G-G-S-G-R-K-F-A-N-I-G-D-V-I-V-A-S-V-K-Q-A-T-P-G-G-A-V-K-K-G-D-V-V-K-A-V-I-V-R-T-K-T-G-A-R-R-P-D-G-S-Y-I-K-F-D-D-N-A-A-V-I-I-R-D-D-K-T-P-R-G-T-R-I-F-G-P-V-A-R-E-L-R-E-G-G-Y-M-K-I-V-S-L-A-P-E-V-L


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-E-R-N-Q-R-K-T-L-Y-G-R-V-V-S-D-K-M-D-K-T-I-T-V-V-V-E-T-K-R-N-H-P-V-Y-G-K-R-I-N-Y-S-K-K-Y-K-A-H-D-E-N-N-V-A-K-E-G-D-I-V-R-I-M-E-T-R-P-L-S-A-T-K-R-F-R-L-V-E-V-V-E-K-A-V-I-I


### FUNCTION Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs ### SEQUENCE -M-L-V-P-K-R-V-K-H-R-R-E-F-R-G-K-M-R-G-E-A-K-G-G-K-E-V-S-F-G-E-Y-G-L-Q-A-T-T-S-H-W-I-T-N-R-Q-I-E-A-A-R-I-A-M-T-R-Y-M-K-R-G-G-K-V-W-I-K-I-F-P-H-K-S-Y-T-A-K-A-I-G-V-R-M-G-S-G-K-G-A-P-E-G-W-V-A-P-V-K-R-G-K-V-M-F-E-I-A-G-V-S-E-E-I-A-R-E-A-L-R-L-A-S-H-K-L-P-V-K-C-K-F-V-K-R-E-A-E


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-A-E-I-T-S-A-K-A-M-A-R-T-V-R-V-S-P-R-K-T-R-L-V-L-D-L-I-R-G-K-K-V-A-D-A-I-A-I-L-K-F-T-P-N-K-A-A-R-V-I-E-K-T-L-N-S-A-I-A-N-A-E-N-N-F-G-L-E-K-A-N-L-V-V-S-E-T-F-A-N-E-G-P-T-M-K-R-F-R-P-R-A-K-G-S-A-S-P-I-N-K-R-T-T-H-V-T-V-V-V-S-E-K


### FUNCTION One of the early assembly proteins it binds 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome Forms the main docking site for trigger factor binding to the ribosome ### SEQUENCE -M-N-L-Y-D-V-I-K-K-P-V-I-T-E-K-S-M-I-A-L-E-A-G-K-Y-T-F-E-V-D-T-R-A-H-K-L-L-I-K-Q-A-V-E-A-A-F-D-G-V-K-V-A-S-V-N-T-V-N-V-K-P-K-A-K-R-V-G-R-Y-T-G-F-T-S-K-T-K-K-A-I-I-T-L-T-A-D-S-K-A-I-E-L-F-A-A-E-A-E


### FUNCTION Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose Essential for virulence May be involved in LPS biosynthesis or polysaccharide transport ### SEQUENCE -M-N-S-F-R-K-T-C-A-G-A-L-A-L-I-F-G-A-T-S-I-V-P-T-V-A-A-P-M-N-M-D-R-P-A-I-N-Q-N-V-I-Q-A-R-A-H-Y-R-P-Q-N-Y-N-R-G-H-R-P-G-Y-W-H-G-H-R-G-Y-R-H-Y-R-H-G-Y-R-R-H-N-D-G-W-W-Y-P-L-A-A-F-G-A-G-A-I-I-G-G-A-I-S-Q-P-R-P-V-Y-R-A-P-A-G-S-P-H-V-Q-W-C-Y-S-R-Y-K-S-Y-R-A-S-D-N-T-F-Q-P-Y-N-G-P-R-K-Q-C-R-S-P-Y-S-R


### FUNCTION Involved in urease metallocenter assembly Binds nickel Probably functions as a nickel donor during metallocenter assembly ### SEQUENCE -M-F-R-A-I-A-I-I-R-A-H-E-V-I-D-A-V-P-A-S-H-I-V-L-E-R-D-E-R-H-L-R-R-K-A-I-T-L-E-N-G-E-K-I-L-A-D-F-A-E-P-V-V-L-E-H-G-D-R-L-V-L-D-D-G-R-E-I-E-I-R-A-A-S-E-E-L-Y-E-I-R-G-R-D-P-R-H-I-A-E-L-A-W-H-I-G-N-R-H-L-A-A-Q-I-E-T-D-H-I-F-I-L-R-D-H-V-I-R-V-M-L-E-G-L-G-A-T-V-T-D-V-V-A-I-F-S-P-L-R-G-A-Y-S-G-G-H-Q-H-H-H-G-H-D-H-D-H-G-H-H-G-H-D-H-D-H-H-H-P-D-H-E


### FUNCTION Guanidinium ion exporter Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons ### SEQUENCE -M-S-W-I-I-L-L-I-A-G-L-L-E-V-V-W-A-V-G-L-K-Y-T-H-G-F-S-R-L-T-P-S-I-I-T-I-T-A-M-V-I-S-M-A-L-L-S-W-A-M-K-T-L-P-V-G-T-A-Y-A-I-W-T-G-I-G-A-V-G-A-A-I-T-G-I-L-L-L-G-E-S-A-S-P-A-R-L-L-S-L-G-L-I-V-A-G-I-I-G-L-K-L-S-A-H


### FUNCTION Involved in resistance toward heavy metals ### SEQUENCE -M-L-D-V-K-S-Q-D-I-S-I-P-E-A-V-V-V-L-C-T-A-P-D-E-A-T-A-Q-D-L-A-A-K-V-L-A-E-K-L-A-A-C-A-T-L-L-P-G-A-T-S-L-Y-Y-W-E-G-K-L-E-Q-E-Y-E-V-Q-M-I-L-K-T-T-V-S-H-Q-Q-A-L-I-D-C-L-K-S-H-H-P-Y-Q-T-P-E-L-L-V-L-P-V-T-H-G-D-T-D-Y-L-S-W-L-N-A-S-L-R


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-N-L-N-A-T-I-L-G-Q-A-I-A-F-I-L-F-V-W-F-C-M-K-Y-V-W-P-P-L-M-A-A-I-E-K-R-Q-K-E-I-A-D-G-L-A-S-A-E-R-A-H-K-D-L-D-L-A-K-A-S-A-T-D-Q-L-K-K-A-K-A-E-A-Q-V-I-I-E-Q-A-N-K-R-R-A-Q-I-L-D-E-A-K-T-E-A-E-Q-E-R-T-K-I-V-A-Q-A-Q-A-E-I-E-A-E-R-K-R-A-R-E-E-L-R-K-Q-V-A-I-L-A-V-A-G-A-E-K-I-I-E-R-S-V-D-E-A-A-N-S-D-I-V-D-K-L-V-A-E-L


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-S-E-F-V-T-V-A-R-P-Y-A-K-A-A-F-D-F-A-V-E-H-Q-S-V-E-R-W-Q-D-M-L-A-F-A-A-E-V-T-K-N-E-Q-M-A-E-L-L-S-G-A-L-A-P-E-T-L-A-E-S-F-I-A-V-C-G-E-Q-L-D-E-N-G-Q-N-L-I-R-V-M-A-E-N-N-R-L-N-A-L-P-D-V-L-E-Q-F-I-H-L-R-A-A-S-E-A-T-S-E-V-E-V-T-S-A-T-A-L-S-E-E-Q-L-S-K-I-S-A-A-M-E-K-R-L-S-R-K-V-K-L-N-C-K-I-D-K-S-V-M-A-G-V-I-I-R-A-G-D-M-V-I-D-G-S-V-R-G-R-L-E-R-L-A-D-V-L-Q-S


### FUNCTION Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE Its activity is ATP-independent ### SEQUENCE -M-R-N-F-D-L-S-P-L-Y-R-S-A-I-G-F-D-R-L-F-N-L-L-E-N-N-Q-S-Q-S-N-G-G-Y-P-P-Y-N-V-E-L-V-D-E-N-H-Y-R-I-A-I-A-V-A-G-F-A-E-S-E-L-E-I-T-A-Q-D-N-L-L-V-V-K-G-A-H-A-D-E-Q-K-E-R-T-Y-L-Y-Q-G-I-A-E-R-N-F-E-R-K-F-Q-L-A-E-N-I-H-V-R-G-A-N-L-V-N-G-L-L-Y-I-E-L-E-R-V-I-P-E-A-N-K-P-R-R-I-E-I-N


### FUNCTION One of the proteins required for the normal export of preproteins out of the cell cytoplasm It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state It also specifically binds to its receptor SecA ### SEQUENCE -M-S-E-Q-N-N-T-E-M-A-F-Q-I-Q-R-I-Y-T-K-D-V-S-F-E-A-P-N-A-P-H-V-F-Q-K-D-W-Q-P-E-V-K-L-D-L-D-T-A-S-S-Q-L-A-D-D-V-Y-E-V-V-L-R-V-T-V-T-A-S-L-G-E-E-T-A-F-L-C-E-V-Q-Q-A-G-I-F-S-I-S-G-I-E-G-T-Q-M-A-H-C-L-G-A-Y-C-P-N-I-L-F-P-Y-A-R-E-C-I-T-S-L-V-S-R-G-T-F-P-Q-L-N-L-A-P-V-N-F-D-A-L-F-M-N-Y-L-Q-Q-Q-A-G-E-G-T-E-E-H-Q-D-A


### FUNCTION Required for cellulose biosynthesis ### SEQUENCE -M-M-T-I-S-D-I-V-Q-I-I-L-F-C-A-L-I-F-F-P-L-G-Y-L-A-R-H-S-L-R-R-I-S-D-T-T-R-L-L-F-A-K-P-R-Y-V-K-P-A-G-T-L-R-R-A-T-K-V-K-A-D-K-K


### FUNCTION May function as a transcriptional regulator that controls feoABC expression ### SEQUENCE -M-A-S-L-I-Q-V-R-D-L-L-A-L-R-G-R-M-E-A-T-Q-I-S-H-T-L-H-A-P-Q-P-M-I-D-A-M-L-N-Q-L-E-I-M-G-K-A-V-R-I-P-E-E-P-D-G-C-L-S-G-S-C-K-S-C-P-E-G-K-A-C-L-R-E-W-W-A-L-R


### FUNCTION One of the early assembly proteins it binds 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome Forms the main docking site for trigger factor binding to the ribosome ### SEQUENCE -M-I-R-E-E-R-L-L-K-V-L-R-A-P-H-V-S-E-K-A-S-T-A-M-E-K-T-N-T-I-V-L-K-V-A-K-D-A-T-K-A-E-I-K-A-A-V-Q-K-L-F-E-V-E-V-E-V-V-N-T-L-V-V-K-G-K-V-K-R-H-G-Q-R-I-G-R-R-S-D-W-K-K-A-Y-V-T-L-K-E-G-Q-N-L-D-F-V-G-G-A-E


### FUNCTION Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs ### SEQUENCE -M-L-Q-P-K-R-T-K-F-R-K-M-H-K-G-R-N-R-G-L-A-A-G-A-D-V-S-F-G-S-F-G-L-K-A-V-G-R-G-R-L-T-A-R-Q-I-E-A-A-R-R-A-M-T-R-A-V-K-R-Q-G-K-I-W-I-R-V-F-P-D-K-P-I-T-E-K-P-L-A-V-R-M-G-K-G-K-G-N-V-E-Y-W-V-A-L-I-Q-P-G-K-V-L-Y-E-M-D-G-V-P-E-E-L-A-R-E-A-F-K-L-A-A-A-K-L-P-I-K-T-T-F-V-T-K-T-V-M


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-E-Q-T-M-L-N-V-A-D-N-S-G-A-R-R-V-M-C-I-K-V-L-G-G-S-H-R-R-Y-A-G-V-G-D-I-I-K-I-T-I-K-E-A-I-P-R-G-K-V-K-K-G-D-V-L-K-A-V-V-V-R-T-K-K-G-V-R-R-P-D-G-S-V-I-R-F-D-G-N-A-C-V-I-L-N-N-N-S-E-Q-P-I-G-T-R-I-F-G-P-V-T-R-E-L-R-N-E-K-F-M-K-I-I-S-L-A-P-E-V-L


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-D-K-K-S-A-R-I-R-R-A-T-R-A-R-R-K-L-K-E-L-G-A-T-R-L-V-V-H-R-T-P-R-H-I-Y-A-Q-V-I-A-P-N-G-S-E-V-L-V-A-A-S-T-V-E-K-A-I-A-E-Q-L-K-Y-T-G-N-K-D-A-A-A-A-V-G-K-A-V-A-E-R-A-L-E-K-G-I-K-D-V-S-F-D-R-S-G-F-Q-Y-H-G-R-V-Q-A-L-A-D-A-A-R-E-A-G-L-Q-F


### FUNCTION This protein binds to 23S rRNA in the presence of protein L20 ### SEQUENCE -M-Y-A-V-F-Q-S-G-G-K-Q-H-R-V-S-E-G-Q-T-V-R-L-E-K-L-D-I-A-T-G-E-T-I-E-F-A-E-V-L-M-I-A-N-G-E-E-V-K-I-G-V-P-F-V-D-G-G-V-I-K-A-E-V-V-A-H-G-R-G-E-K-V-K-I-V-K-F-R-R-R-K-H-Y-R-K-Q-Q-G-H-R-Q-W-F-T-D-V-K-I-T-G-I-S-A


### FUNCTION Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring It is recruited early at mid-cell but it is not essential for cell division ### SEQUENCE -M-S-A-Q-P-V-D-I-Q-I-F-G-R-S-L-R-V-N-C-P-P-D-Q-R-D-A-L-N-Q-A-A-D-D-L-N-Q-R-L-Q-D-L-K-V-R-T-R-V-T-N-T-E-Q-L-V-F-I-A-A-L-N-I-S-Y-E-L-T-Q-E-K-A-K-T-R-D-Y-A-A-S-M-E-Q-R-I-R-M-L-Q-Q-T-I-E-Q-A-L-L-D-Q-G-R-I-T-E-K-T-G-Q-N-F-E


### FUNCTION An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins Plays an essential role in the assembly of succinate dehydrogenase  of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well ### SEQUENCE -M-D-I-H-N-K-A-R-I-H-W-A-C-R-R-G-M-R-E-L-D-I-S-I-M-P-F-F-E-H-E-Y-D-S-L-S-D-E-E-K-R-I-F-V-R-L-L-Q-S-D-D-P-D-L-F-N-W-L-M-N-H-G-K-P-A-D-A-E-L-E-Q-M-V-R-L-I-Q-T-R-N-R-E-R-G-P-V-A-I


### FUNCTION Antitoxin component of a type II toxin-antitoxin  system Upon expression in Ecoli neutralizes the effect of cognate toxin VapC ### SEQUENCE -M-H-T-T-L-F-F-S-N-R-T-Q-A-V-R-L-P-K-S-I-S-F-P-E-D-V-K-H-V-E-I-I-A-V-G-R-S-R-I-I-T-P-V-G-E-S-W-D-S-W-F-D-G-E-G-A-S-T-D-F-M-S-T-R-E-Q-P-A-V-Q-E-R-E-G-F


### FUNCTION Repressor of rcnA expression Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt In the presence of one of these metals, it has a weaker affinity for rcnA promoter ### SEQUENCE -M-S-H-T-I-R-D-K-Q-K-L-K-A-R-T-S-K-I-Q-G-Q-V-I-A-L-K-K-M-L-D-E-P-H-E-C-A-A-V-L-Q-Q-I-A-A-I-R-G-A-V-N-G-L-M-R-E-V-I-K-G-H-L-T-E-H-I-V-H-Q-S-D-E-A-R-R-E-E-D-L-D-V-I-L-K-V-L-D-S-Y-I-K


### FUNCTION Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ### SEQUENCE -M-R-C-K-T-L-T-A-A-A-A-V-L-L-M-L-T-A-G-C-S-T-L-E-R-V-V-Y-R-P-D-I-N-Q-G-N-Y-L-T-P-T-D-V-A-K-V-R-V-G-M-T-Q-Q-Q-V-A-Y-A-L-G-T-P-M-M-T-D-P-F-G-T-N-T-W-F-Y-V-F-R-Q-Q-P-G-H-E-N-V-T-Q-Q-T-L-T-L-T-F-N-S-S-G-V-L-T-N-I-D-N-K-P-A-L-T-K


### FUNCTION Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ ### SEQUENCE -M-S-S-K-E-Q-K-T-P-E-G-Q-A-P-E-E-I-I-M-D-Q-H-E-E-V-E-A-V-E-P-N-D-S-A-E-Q-V-D-P-R-D-E-K-I-A-N-L-E-V-Q-L-A-E-A-Q-T-R-E-R-D-T-V-L-R-I-K-A-E-M-E-N-L-R-R-R-T-E-Q-D-I-E-K-A-H-K-F-A-L-E-K-F-V-N-E-L-L-P-V-I-D-S-L-D-R-A-L-E-V-A-D-K-A-N-P-D-M-A-A-M-V-E-G-I-E-L-T-L-K-S-M-L-D-V-V-R-K-F-G-V-E-V-I-A-E-T-N-V-P-L-D-P-N-V-H-Q-A-I-A-M-V-E-S-E-E-V-P-A-G-N-V-L-G-I-M-Q-K-G-Y-T-L-N-G-R-T-I-R-A-A-M-V-T-V-A-K-A-K


### FUNCTION Acts as a radical domain for damaged PFL and possibly other radical proteins ### SEQUENCE -M-I-T-G-I-Q-I-T-K-A-A-N-D-D-L-L-N-S-F-W-L-L-D-S-E-K-G-E-A-R-C-I-V-A-K-S-G-F-A-E-D-E-V-V-A-V-S-K-L-G-E-I-E-Y-R-E-I-P-M-E-V-K-P-E-V-R-V-E-G-G-Q-H-L-N-V-N-V-L-R-R-E-T-L-E-D-A-V-K-H-P-E-K-Y-P-Q-L-T-I-R-V-S-G-Y-A-V-R-F-N-S-L-T-P-E-Q-Q-R-D-V-I-A-R-T-F-T-E-S-L


### FUNCTION Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins ### SEQUENCE -M-R-L-T-S-K-G-R-Y-A-V-T-A-M-L-D-V-A-L-N-S-E-A-G-P-V-P-L-A-D-I-S-E-R-Q-G-I-S-L-S-Y-L-E-Q-L-F-S-R-L-R-K-N-G-L-V-S-S-V-R-G-P-G-G-G-Y-L-L-G-K-D-A-G-S-I-A-V-G-E-V-I-S-A-V-D-E-S-V-D-A-T-R-C-Q-G-K-G-G-C-Q-G-G-D-K-C-L-T-H-A-L-W-R-D-L-S-D-R-L-T-G-F-L-N-N-I-T-L-G-E-L-V-N-N-Q-E-V-L-D-V-S-G-R-Q-H-T-H-D-A-P-R-A-S-G-R-A-Q-D-A-I-D-V-K-L-R-A


### FUNCTION Is able to transfer iron-sulfur clusters to apo-ferredoxin Multiple cycles of  cluster formation and transfer are observed, suggesting that IscA acts catalytically Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB ### SEQUENCE -M-S-I-T-L-S-D-S-A-A-A-R-V-N-T-F-L-A-N-R-G-K-G-F-G-L-R-L-G-V-R-T-S-G-C-S-G-M-A-Y-V-L-E-F-V-D-E-P-T-A-E-D-T-V-F-E-D-K-G-V-K-V-V-V-D-G-K-S-L-Q-F-L-D-G-T-Q-L-D-F-V-K-E-G-L-N-E-G-F-K-F-S-N-P-N-V-K-D-E-C-G-C-G-E-S-F-H-V


### FUNCTION This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ### SEQUENCE -M-F-T-I-N-A-E-V-R-K-E-Q-G-K-G-A-S-R-R-L-R-A-A-N-K-F-P-A-I-I-Y-G-G-S-E-A-P-I-A-I-E-L-D-H-D-Q-V-M-N-M-Q-A-K-A-E-F-Y-S-E-V-L-T-L-V-V-D-G-K-E-V-K-V-K-A-Q-A-V-Q-R-H-A-Y-K-P-K-L-T-H-I-D-F-V-R-A


### FUNCTION PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP ### SEQUENCE -M-K-K-F-R-W-V-V-L-G-I-V-V-V-V-C-L-L-L-W-A-Q-V-F-N-I-M-C-D-Q-D-V-Q-F-F-S-G-I-C-A-I-N-K-F-I-P-W


### FUNCTION Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein ### SEQUENCE -M-K-S-N-R-Q-A-R-H-I-L-G-L-D-Y-R-I-S-N-Q-R-K-V-V-T-E-G-D-T-S-S-V-V-N-N-P-T-G-R-K-R-R-A-D-S-Q-K


### FUNCTION Binds to H-NS and modified the range of genes it silences ### SEQUENCE -M-T-V-Q-D-Y-L-L-K-F-R-K-I-S-S-L-E-S-L-E-K-L-F-D-H-L-N-Y-T-L-T-D-D-M-D-I-V-N-M-Y-R-A-A-D-H-R-R-A-E-L-V-S-G-G-R-L-F-D-V-G-Q-V-P-Q-S-V-W-R-Y-V-Q


### FUNCTION Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine ### SEQUENCE -M-L-I-F-E-G-K-E-I-S-T-D-S-E-G-Y-L-K-E-T-T-Q-W-S-E-A-L-A-V-A-I-A-A-N-E-G-I-E-L-S-A-E-H-W-E-V-V-R-F-V-R-E-F-Y-L-E-F-N-T-S-P-A-I-R-M-L-V-K-A-M-A-N-K-F-G-E-E-K-G-N-S-R-Y-L-Y-R-L-F-P-K-G-P-A-K-Q-A-T-K-I-A-G-L-P-K-P-V-K-C-I


### FUNCTION Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress ### SEQUENCE -M-I-A-S-K-F-G-I-G-Q-Q-V-R-H-S-L-L-G-Y-L-G-V-V-V-D-I-D-P-E-Y-S-L-D-E-P-S-P-D-E-L-A-V-N-D-E-L-R-A-A-P-W-Y-H-V-V-M-E-D-D-D-G-Q-P-V-H-T-Y-L-A-E-A-Q-L-R-S-E-M-R-D-E-H-P-E-Q-P-S-M-D-E-L-A-R-T-I-R-K-Q-L-Q-A-P-R-L-R-N


### FUNCTION Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins Repression is relieved when the region becomes fully methylated ### SEQUENCE -M-K-T-I-E-V-D-D-E-L-Y-S-Y-I-A-S-H-T-K-H-I-G-E-S-A-S-D-I-L-R-R-M-L-K-F-S-A-T-T-Q-P-T-A-S-A-V-K-G-T-P-A-A-Q-P-V-A-E-A-K-P-V-N-P-V-K-D-K-V-R-A-M-R-E-L-L-L-S-D-E-Y-A-E-Q-K-K-A-V-N-R-F-M-L-I-L-T-T-L-Y-S-L-D-H-H-A-F-A-E-A-T-E-S-L-H-G-R-T-R-V-Y-F-A-A-D-E-Q-T-L-L-K-N-G-N-Q-T-K-P-K-H-V-P-G-T-P-Y-W-V-I-T-N-T-N-T-G-R-K-C-S-M-I-E-H-I-M-Q-S-M-Q-F-P-A-E-L-I-E-K-V-C-G-T-I


### FUNCTION Covalent carrier of the coenzyme of citrate lyase ### SEQUENCE -M-K-I-N-Q-L-A-V-A-G-T-L-E-S-G-D-V-M-I-R-I-A-P-L-D-T-Q-D-I-D-L-Q-I-N-S-S-V-E-K-Q-F-G-E-A-I-R-A-T-I-L-E-V-L-S-R-Y-D-V-R-G-V-Q-L-N-V-D-D-K-G-A-L-D-C-I-L-R-A-R-L-E-T-L-L-A-R-A-S-G-I-A-A-L-P-W-E-D-R-Q


### FUNCTION Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP ### SEQUENCE -M-N-F-L-A-H-L-H-L-A-H-L-A-D-S-S-L-S-G-N-L-L-A-D-F-V-R-G-N-P-A-T-H-Y-P-P-D-V-V-E-G-I-Y-M-H-R-R-I-D-V-M-T-D-N-L-P-E-V-R-E-A-R-E-W-F-R-H-E-T-R-R-V-A-P-I-T-L-D-V-M-W-D-H-F-L-S-R-H-W-T-Q-I-S-P-D-F-P-L-Q-A-F-V-G-Y-A-H-A-Q-V-A-T-I-L-P-D-S-P-P-R-F-V-N-L-N-D-Y-L-W-S-E-K-W-L-E-R-Y-R-D-M-D-F-I-Q-N-V-L-N-G-M-A-N-R-R-P-R-L-D-A-L-R-D-S-W-Y-D-L-D-A-H-Y-D-A-L-E-E-R-F-W-H-F-Y-P-R-M-M-A-Q-A-A-R-K-A-L


### FUNCTION Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate and magnesium starvation, but also in stationary phase and during nitrogen starvation Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway ### SEQUENCE -M-K-N-L-I-A-E-L-L-L-K-L-A-Q-K-E-E-E-S-K-E-L-V-A-Q-V-E-A-L-E-I-I-V-T-A-M-L-R-N-M-A-Q-N-E-Q-E-M-L-I-R-Q-V-E-G-A-L-E-G-V-K-P-D-A-S-V-P-D-H-D-T-E-L-L-R-Q-Y-V-K-K-L-L-R-H-P-R-H


### FUNCTION Required for insertion of 4Fe-4S clusters for at least IspG ### SEQUENCE -M-S-D-D-V-A-L-P-L-Q-F-T-D-A-A-A-N-K-V-K-S-L-I-A-D-E-D-N-P-N-L-K-L-R-V-Y-I-T-G-G-G-C-S-G-F-Q-Y-G-F-T-F-D-D-Q-V-N-E-G-D-M-T-I-E-K-Q-G-V-G-L-V-V-D-P-M-S-L-Q-Y-L-V-G-G-S-V-D-Y-T-E-G-L-E-G-S-R-F-I-V-T-N-P-N-A-K-S-T-C-G-C-G-S-S-F-S-I


### FUNCTION Essential cell division protein May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ### SEQUENCE -M-I-S-R-V-T-E-A-L-S-K-V-K-G-S-I-G-S-N-E-R-H-A-L-P-G-V-I-G-D-D-L-L-R-F-G-K-L-P-L-C-L-F-I-C-I-I-L-T-A-V-T-V-V-T-T-A-H-H-T-R-L-L-T-A-Q-R-E-Q-L-V-L-E-R-D-A-L-D-I-E-W-R-N-L-I-L-E-E-N-A-L-G-D-H-S-R-V-E-R-I-A-T-E-K-L-Q-M-Q-H-V-D-P-S-Q-E-N-I-V-V-Q-K


### FUNCTION Covalent carrier of the coenzyme of citrate lyase ### SEQUENCE -M-K-I-I-K-D-A-L-A-G-T-L-E-S-S-D-V-M-I-R-I-G-P-S-S-E-P-G-I-R-L-E-L-E-S-L-V-K-Q-Q-F-G-A-A-I-E-Q-V-V-R-E-T-L-A-K-L-G-V-E-R-A-L-V-S-V-D-D-K-G-A-L-E-C-I-L-R-A-R-V-Q-A-A-A-L-R-A-A-E-Q-T-E-I-Q-W-S-A-L


### FUNCTION This protein is involved in control of the biosynthesis of threonine ### SEQUENCE -M-N-R-I-S-T-T-T-I-T-T-I-T-I-T-T-G-N-G-A-G


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-P-V-A-E-T-S-Q-G-T-S-G-V-A-E-R-Y-A-S-S-L-F-E-L-A-L-E-A-G-T-V-E-A-V-Q-V-E-L-D-K-F-G-A-L-L-D-E-S-D-D-L-K-R-L-V-A-S-P-V-F-S-A-E-D-Q-F-K-A-I-S-A-I-C-E-K-A-G-I-A-G-L-A-V-N-F-L-K-V-V-A-N-N-R-R-L-F-A-V-P-G-M-I-R-A-Y-R-T-I-A-A-A-H-R-G-E-I-T-A-E-V-T-S-A-H-A-L-D-E-A-Q-E-T-E-L-K-A-A-L-K-S-V-T-G-K-D-V-A-I-S-V-T-V-D-P-S-I-L-G-G-L-I-V-K-V-G-S-R-Q-I-D-T-S-L-R-T-K-L-S-T-L-K-L-A-L-K-E-V-G


### FUNCTION Involved in pyrimidine catabolism Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions ### SEQUENCE -M-P-K-K-I-I-V-P-V-G-T-S-K-P-I-A-P-F-S-P-G-T-L-A-D-G-V-V-Y-V-S-G-T-L-P-F-D-K-D-N-N-V-V-H-V-G-D-A-S-A-Q-T-R-H-V-L-E-T-I-K-S-V-I-E-T-A-G-G-T-M-E-D-V-T-M-N-H-I-F-I-T-D-W-A-N-Y-Q-A-V-N-T-V-Y-A-E-Y-F-P-G-D-K-P-A-R-Y-C-I-Q-C-G-L-V-K-P-D-A-L-V-E-I-A-T-V-A-H-I-G-K


### FUNCTION Catalyzes the transfer of an acetyl group from acetyl coenzyme A -acetylspermidine, chloramphenicol, puromycin, polymyxin B, and 4-aminobutyrate ethyl ester ### SEQUENCE -M-N-F-V-L-S-D-V-A-D-A-E-A-E-K-A-I-R-D-P-L-V-A-Y-N-L-A-R-F-G-E-S-D-K-R-D-L-N-I-T-I-R-N-D-D-N-S-V-T-G-G-L-V-G-H-T-A-R-G-W-L-Y-V-Q-L-L-F-V-P-E-A-M-R-G-Q-G-I-A-P-K-L-L-A-M-A-E-E-E-A-R-K-R-G-C-M-G-A-Y-I-D-T-M-N-P-D-A-L-R-T-Y-E-R-Y-G-F-T-K-I-G-S-L-G-P-L-S-S-G-Q-S-I-T-W-L-E-K-R-F


### FUNCTION Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors , playing an important role in chemotaxis ### SEQUENCE -M-M-E-A-A-A-K-R-V-H-I-I-Q-G-E-Y-K-V-V-S-D-P-D-V-V-M-T-T-I-L-G-S-C-V-A-A-C-L-R-D-P-V-A-G-L-G-G-M-N-H-F-L-L-P-G-T-G-N-V-T-G-G-D-A-T-R-Y-G-V-H-L-M-E-L-L-I-N-G-L-L-K-Q-G-A-R-R-D-R-L-E-A-K-V-F-G-G-A-K-T-I-A-S-F-S-N-V-G-E-Q-N-A-I-F-A-M-Q-F-L-K-D-E-G-I-P-V-I-S-S-S-T-G-G-D-H-G-R-K-I-E-F-W-P-V-S-G-R-A-R-Q-H-P-L-S-G-A-E-T-Q-K-T-V-A-M-E-T-R-P-V-P-A-P-K-P-V-A-N-D-I-E-F-F


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-K-T-F-S-A-K-P-H-E-V-K-R-E-W-F-V-I-D-A-Q-D-K-V-L-G-R-V-A-A-E-V-A-S-R-L-R-G-K-H-K-P-E-Y-T-P-H-V-D-T-G-D-Y-I-I-V-I-N-A-D-K-L-R-V-T-G-A-K-F-E-D-K-K-Y-F-R-H-S-G-F-P-G-G-I-Y-E-R-T-F-R-E-M-Q-E-Q-F-P-G-R-A-L-E-Q-A-V-K-G-M-L-P-K-G-P-L-G-Y-A-M-I-K-K-L-K-V-Y-A-G-A-E-H-A-H-A-A-Q-Q-P-K-V-L-E-L-K


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-N-I-N-A-T-L-F-A-Q-I-I-V-F-F-G-L-V-W-F-T-M-K-F-V-W-P-P-I-A-K-A-L-D-E-R-A-A-K-V-A-E-G-L-A-A-A-E-R-G-K-S-D-F-E-Q-A-E-K-K-V-A-E-L-L-A-E-G-R-N-Q-V-S-E-M-V-A-N-A-E-K-R-A-A-K-I-V-E-E-A-K-E-Q-A-S-S-E-A-A-R-I-A-A-Q-A-K-A-D-V-E-Q-E-L-F-R-A-R-E-S-L-R-E-Q-V-A-V-L-A-V-K-G-A-E-S-I-L-R-S-E-V-D-A-S-K-H-A-K-L-L-D-T-L-K-Q-E-L


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA ### SEQUENCE -M-A-L-T-V-E-Q-K-A-Q-I-V-K-D-F-Q-R-K-E-G-D-T-G-S-S-E-V-Q-V-A-L-L-T-F-R-I-N-D-L-T-P-H-F-K-A-N-P-K-D-H-H-S-R-R-G-L-L-K-M-V-S-Q-R-R-R-L-L-A-Y-L-R-R-T-Q-P-D-T-Y-R-A-L-I-T-R-L-G-L-R-K


### FUNCTION Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ ### SEQUENCE -M-S-E-Q-T-Q-Q-Q-N-S-E-E-A-V-E-N-V-E-A-V-E-T-V-E-T-V-G-N-A-D-G-V-Q-E-Q-A-A-A-E-P-A-Y-E-D-L-Q-A-R-I-A-E-L-E-A-Q-L-K-D-E-Q-L-R-A-L-A-N-E-Q-N-L-R-R-R-H-Q-Q-E-I-A-D-T-H-K-F-A-G-Q-K-F-A-V-E-M-L-P-V-K-D-Y-L-E-M-A-L-L-D-Q-S-G-N-F-D-A-L-K-M-G-V-Q-M-T-L-N-E-L-Q-K-A-F-D-A-T-Q-I-K-E-I-N-P-K-A-G-D-K-L-D-P-N-I-H-Q-A-M-Q-A-V-A-S-E-Q-E-P-N-T-V-V-G-V-M-K-K-G-Y-T-L-S-D-R-V-L-R-P-A-M-V-T-V-A-Q-K-E-A


### FUNCTION Required for insertion of 4Fe-4S clusters ### SEQUENCE -M-S-D-E-S-P-I-I-F-T-D-S-C-C-A-K-V-A-D-L-I-A-E-E-N-N-P-D-L-K-L-R-V-F-V-N-G-G-G-C-S-G-F-Q-Y-G-F-T-F-D-E-I-K-N-D-D-D-F-E-I-E-K-N-G-L-V-F-L-V-D-P-M-S-Y-Q-Y-L-V-G-A-E-I-D-Y-T-E-S-L-Q-G-S-Q-F-V-I-R-N-P-N-A-E-T-T-C-G-C-G-S-S-F-S-V


### FUNCTION Essential cell division protein May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ### SEQUENCE -M-A-M-N-K-L-N-F-L-L-L-L-A-V-C-V-S-A-F-S-V-V-M-Q-Q-N-Q-Y-R-L-N-F-T-A-L-D-K-A-K-K-Q-E-I-A-L-E-Q-D-Y-A-Q-M-R-L-Q-Q-A-R-L-A-N-H-E-A-I-R-A-A-A-E-K-Q-N-L-H-P-P-V-S-G-N-T-F-M-V-E-H-Q-R


### FUNCTION This protein binds to 23S rRNA in the presence of protein L20 ### SEQUENCE -M-Y-A-V-V-K-T-G-G-K-Q-Y-K-V-S-V-G-E-K-L-K-V-E-Q-I-P-A-E-L-D-S-Q-I-E-L-T-E-V-L-M-I-A-D-G-E-S-V-K-V-G-A-P-F-I-E-G-A-K-V-T-A-K-V-V-A-H-G-R-G-E-K-V-R-I-F-K-M-R-R-R-K-H-Y-Q-K-R-Q-G-H-R-Q-N-F-T-Q-I-E-I-V-A-I-A


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-D-K-H-T-T-R-L-R-R-A-R-K-T-R-A-R-I-A-D-L-K-M-V-R-L-C-V-F-R-S-N-N-H-I-Y-A-Q-V-I-S-A-E-G-D-K-V-L-A-Q-A-S-T-L-E-A-E-V-R-G-S-L-K-S-G-S-N-V-E-A-A-A-I-V-G-K-R-I-A-E-K-A-K-A-A-G-V-E-K-V-A-F-D-R-S-G-F-Q-Y-H-G-R-V-K-A-L-A-E-A-A-R-E-N-G-L-S-F


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-M-Q-T-I-L-D-V-A-D-N-S-G-A-R-R-V-M-C-I-K-V-L-G-G-S-K-R-R-Y-A-S-V-G-D-I-I-K-V-A-V-K-D-A-A-P-R-G-R-V-K-K-G-D-V-Y-N-A-V-V-V-R-T-A-K-G-V-R-R-P-D-G-A-L-I-K-F-D-N-N-A-A-V-L-L-N-N-K-L-E-P-L-G-T-R-I-F-G-P-V-T-R-E-L-R-T-E-R-F-M-K-I-V-S-L-A-P-E-V-L


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-S-E-T-K-N-V-R-T-L-Q-G-K-V-V-S-D-K-M-D-K-T-V-T-V-L-V-E-R-K-V-K-H-P-L-Y-G-K-I-I-R-L-S-T-K-I-H-A-H-D-E-N-N-Q-Y-G-I-G-D-V-V-V-I-S-E-S-R-P-L-S-K-T-K-S-W-V-V-S-E-L-V-E-K-A-R-S-I


### FUNCTION Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs ### SEQUENCE -M-L-Q-P-T-R-L-K-Y-R-K-Q-Q-K-G-R-N-T-G-I-A-T-R-G-N-K-V-S-F-G-E-F-G-L-K-A-V-G-R-G-R-L-T-A-R-Q-I-E-A-A-R-R-A-M-T-R-H-I-K-R-G-G-R-I-W-I-R-V-F-P-D-K-P-I-T-E-K-P-I-Q-V-R-M-G-G-G-K-G-N-V-E-Y-Y-I-A-E-I-K-P-G-K-V-L-Y-E-M-D-G-V-P-E-E-L-A-R-E-A-F-E-L-A-A-A-K-L-P-I-P-T-T-F-V-V-R-Q-V-G-Q


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-R-V-N-A-Q-H-K-N-A-R-I-S-A-Q-K-A-R-L-V-A-D-L-I-R-G-K-D-V-A-Q-A-L-N-I-L-A-F-S-P-K-K-G-A-E-L-I-K-K-V-L-E-S-A-I-A-N-A-E-H-N-N-G-A-D-I-D-E-L-K-V-V-T-I-F-V-D-K-G-P-S-L-K-R-F-Q-A-R-A-K-G-R-G-N-R-I-E-K-Q-T-C-H-I-N-V-T-V-G-N


### FUNCTION Binding protein with a strong affinity to the bleomycin family of antibiotics, which confers resistance to these antibiotics by preventing the bleomycin-induced DNA breakage ### SEQUENCE -M-L-Q-S-I-P-A-L-P-V-G-D-I-K-K-S-I-G-F-Y-C-D-K-L-G-F-T-L-V-H-H-E-D-G-F-A-V-L-M-C-N-E-V-R-I-H-L-W-E-A-S-D-E-G-W-R-S-R-S-N-D-S-P-V-C-T-G-A-E-S-F-I-A-G-T-A-S-C-R-I-E-V-E-G-I-D-E-L-Y-Q-H-I-K-P-L-G-I-L-H-P-N-T-S-L-K-D-Q-W-W-D-E-R-D-F-A-V-I-D-P-D-N-N-L-I-S-F-F-Q-Q-I-K-S


### FUNCTION Antitoxin component of a type II toxin-antitoxin  that inhibits the endonuclease activity of cognate toxin LsoA but not that of non-cognate toxin RnlA ### SEQUENCE -M-K-K-D-K-K-Y-Q-I-E-A-I-K-N-K-D-K-T-L-F-I-V-Y-A-T-D-I-Y-S-P-S-E-F-F-S-K-I-E-S-D-L-K-K-K-K-S-K-G-D-V-F-F-D-L-I-I-P-N-G-G-K-K-D-R-Y-V-Y-T-S-F-N-G-E-K-F-S-S-Y-T-L-N-K-V-T-K-T-D-E-Y-N-D-L-S-E-L-S-A-S-F-F-K-K-N-F-D-K-I-N-V-N-L-L-S-K-A-T-S-F-A-L-K-K-G-I-P-I


### FUNCTION Potential calcium sensor ### SEQUENCE -M-S-T-V-K-G-Q-T-R-R-E-R-P-R-G-A-R-P-H-G-L-T-K-Q-K-R-Q-E-I-K-E-A-F-D-L-F-D-T-D-N-S-G-T-I-D-A-K-E-L-N-V-A-M-R-A-L-G-F-E-M-T-E-E-Q-I-N-Q-M-I-A-D-V-D-K-D-G-S-G-S-I-D-Y-E-E-F-E-H-M-M-T-A-K-I-G-E-R-D-S-K-E-E-L-T-K-A-F-S-I-I-D-Q-D-K-N-G-K-I-S-D-V-D-I-Q-R-I-A-K-E-L-G-E-N-F-T-Y-Q-E-I-Q-E-M-V-Q-E-A-D-R-N-G-D-G-E-I-D-F-D-E-F-I-R-M-M-R-R-T-G-Y-G-Y


### FUNCTION Binds to 23S rRNA ### SEQUENCE -M-D-G-I-K-Y-A-V-F-T-D-K-S-I-R-L-L-G-K-N-Q-Y-T-S-N-V-E-S-G-S-T-R-T-E-I-K-H-W-V-E-L-F-F-G-V-K-V-I-A-M-N-S-H-R-L-P-G-K-S-R-R-M-G-P-I-M-G-H-T-M-H-Y-R-R-M-I-I-T-L-Q-P-G-Y-S-I-P-P-L-R-K-K-R-T


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-T-R-S-L-K-K-N-P-F-V-A-N-H-L-L-K-K-I-D-K-L-N-T-K-A-E-K-E-I-I-V-T-W-S-R-A-S-T-I-I-P-T-M-I-G-H-T-I-A-I-H-N-G-K-E-H-L-P-I-Y-I-T-D-S-M-V-G-H-K-L-G-E-F-A-P-T-L-N-F-R-G-H-A-K-S-D-N-R-S-R-R


### FUNCTION Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II , cyclic electron flow around PSI, and state transitions ### SEQUENCE -M-G-V-T-K-K-P-D-L-N-D-P-V-L-R-A-K-L-A-K-G-M-G-H-N-Y-Y-G-E-P-A-W-P-N-D-L-L-Y-I-F-P-V-V-I-L-G-T-I-A-C-N-V-G-L-A-V-L-E-P-S-M-I-G-E-P-A-D-P-F-A-T-P-L-E-I-L-P-E-W-Y-F-F-P-V-F-Q-I-L-R-T-V-P-N-K-L-L-G-V-L-L-M-V-S-V-P-A-G-L-L-T-V-P-F-L-E-N-V-N-K-F-Q-N-P-F-R-R-P-V-A-T-T-V-F-L-I-G-T-A-V-A-L-W-L-G-I-G-A-T-L-P-I-D-K-S-L-T-L-G-L-F


### FUNCTION Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit It is not involved in the protein synthesizing functions of that subunit ### SEQUENCE -M-T-R-I-K-R-G-Y-I-A-R-R-R-R-T-K-I-R-L-F-A-S-S-F-R-G-A-H-S-R-L-T-R-T-I-T-Q-Q-K-I-R-A-L-V-S-A-H-R-D-R-D-R-K-K-R-D-F-R-R-L-W-I-T-R-I-N-A-V-I-R-E-R-G-V-S-Y-S-Y-S-R-L-I-H-D-L-Y-K-R-Q-L-L-L-N-R-K-I-L-A-Q-I-A-I-S-N-R-N-C-L-Y-M-I-S-N-E-I-I-K-E-V-D-W-K-E-S-T-R-I-I


### FUNCTION Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II , cyclic electron flow around PSI, and state transitions PetG is required for either the stability or assembly of the cytochrome b6-f complex ### SEQUENCE -M-I-E-V-F-L-F-G-I-V-L-G-L-I-P-I-T-L-A-G-L-F-V-T-A-Y-L-Q-Y-R-R-G-D-Q-L-D-L


### FUNCTION May help in the organization of the PsaL subunit ### SEQUENCE -M-T-N-L-N-L-P-S-I-F-V-P-L-V-G-L-V-F-P-A-I-A-M-A-S-L-F-L-H-V-Q-K-N-K-I-V


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation This subunit is found at the monomer-monomer interface ### SEQUENCE -M-E-V-N-I-L-A-F-I-A-T-A-L-F-I-L-V-P-T-A-F-L-L-I-I-Y-V-K-T-V-S-Q-N-D


### FUNCTION Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II , cyclic electron flow around PSI, and state transitions ### SEQUENCE -M-D-I-V-S-L-A-W-A-A-L-M-V-V-F-T-F-S-L-S-L-V-V-W-G-R-S-G-L


### FUNCTION Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase Reduces low molecular weight disulfides and proteins ### SEQUENCE -M-D-R-V-N-R-L-A-A-Q-R-A-V-V-I-F-S-M-S-S-C-C-M-C-H-T-V-T-R-L-F-C-E-L-G-V-N-P-T-V-V-E-L-D-E-D-P-R-G-K-E-M-E-K-A-L-A-R-L-L-G-R-S-P-A-V-P-A-V-F-I-G-G-R-L-V-G-S-T-D-K-V-M-S-L-H-L-S-G-N-L-V-P-L-L-R-N-A-G-A-L-W-V


### FUNCTION Acts as a sulfur carrier required for 2-thiolation of mcm that is covalently conjugated via an isopeptide bond to lysine residues of target proteins The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates ### SEQUENCE -M-H-L-T-L-E-F-G-G-G-L-E-L-L-L-E-K-S-T-K-V-H-K-V-D-L-Q-P-N-D-G-D-G-K-V-V-M-K-G-L-L-A-W-V-K-S-N-L-I-K-E-R-P-E-M-F-L-K-G-D-S-V-R-P-G-V-L-V-L-I-N-D-C-D-W-E-L-C-G-G-L-D-A-E-L-E-E-K-D-V-V-V-F-I-S-T-L-H-G-G


### FUNCTION Binds to 23S rRNA ### SEQUENCE -M-I-Q-S-Q-T-Y-L-N-I-A-D-N-S-G-A-R-K-I-M-C-I-R-V-L-G-A-S-N-R-K-C-A-H-I-G-D-V-I-I-A-I-I-K-E-A-V-P-N-M-P-L-E-K-S-E-V-V-R-A-V-V-I-R-T-C-K-E-F-E-R-D-N-G-M-M-I-R-S-D-D-N-A-A-V-V-I-D-Q-E-G-N-P-K-G-T-R-V-F-G-P-V-A-Q-E-L-R-Q-L-N-F-T-K-I-V-S-L-A-P-E-V-L


### FUNCTION May play a role in photosystem I and II biogenesis ### SEQUENCE -M-E-T-A-T-L-V-T-I-S-I-S-C-L-L-V-S-F-T-G-Y-A-L-Y-T-A-F-G-Q-P-S-K-Q-L-R-D-P-F-E-D-H-E-D


### FUNCTION May play a role in photosystem I and II biogenesis ### SEQUENCE -M-E-T-A-T-L-V-A-I-F-I-S-G-L-L-V-S-F-T-G-Y-A-L-Y-T-A-F-G-Q-P-S-Q-Q-L-R-D-P-F-E-E-H-G-D


### FUNCTION Seems to play a role in the dimerization of PSII ### SEQUENCE -M-E-A-L-V-Y-T-F-L-L-V-S-T-L-G-I-I-F-F-A-I-F-F-R-E-P-P-K-I-Q-T-K-K-M-K


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization ### SEQUENCE -M-T-Q-Q-S-N-P-N-E-Q-T-V-E-L-N-R-T-S-L-Y-W-G-L-L-L-I-F-V-L-A-V-L-F-S-N-Y-F-F-N


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization ### SEQUENCE -M-T-Q-S-N-P-N-E-Q-N-V-E-L-N-R-T-S-L-Y-W-G-L-L-L-I-F-V-L-A-V-L-F-S-N-Y-F-F-N


### FUNCTION May play a role in photosystem I and II biogenesis ### SEQUENCE -M-E-T-A-T-L-V-A-I-S-I-S-G-L-L-V-S-F-T-G-Y-A-L-Y-T-A-F-G-Q-P-S-Q-Q-L-R-D-P-F-E-E-H-G-D


### FUNCTION Seems to play a role in the dimerization of PSII ### SEQUENCE -M-E-A-L-V-Y-T-F-L-L-V-S-T-L-G-I-I-F-F-A-I-F-F-R-E-P-P-K-V-P-T-K-K


### FUNCTION Seems to play a role in the dimerization of PSII ### SEQUENCE -M-E-A-L-V-Y-T-F-L-L-V-S-T-L-G-I-I-F-F-A-I-F-F-R-E-P-P-K-V-P-T-K-K-V-K


### FUNCTION May play a role in photosystem I and II biogenesis ### SEQUENCE -M-E-T-A-T-L-V-A-I-S-I-S-G-S-L-V-S-F-T-G-Y-A-L-Y-T-A-F-G-Q-P-S-Q-Q-L-R-D-P-F-E-E-H-G-D


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization ### SEQUENCE -M-T-Q-S-N-P-N-E-Q-S-V-E-L-N-R-T-S-L-Y-W-G-L-L-L-I-F-V-L-A-V-L-F-S-N-Y-F-F-N


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation This subunit is found at the monomer-monomer interface ### SEQUENCE -M-E-V-N-I-L-A-F-I-A-T-A-L-F-I-L-V-P-T-A-F-L-L-I-I-Y-V-K-T-V-S-Q-S-D


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation ### SEQUENCE -M-L-T-L-K-L-F-V-Y-T-V-V-I-F-F-V-S-L-F-I-F-G-F-L-S-N-D-P-G-R-N-P-G-R-E-E


### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-K-E-Q-K-W-I-H-E-G-L-I-T-E-S-L-P-N-G-M-F-R-V-R-L-D-N-E-D-L-I-L-G-Y-V-S-G-K-I-R-R-S-F-I-R-I-L-P-G-D-R-V-K-I-E-V-S-R-Y-D-S-T-R-G-R-I-I-Y-R-L-R-N-K-D-S-K-D


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization ### SEQUENCE -M-T-Q-S-N-P-N-E-Q-N-V-E-L-N-R-T-S-L-Y-W-G-L-L-L-I-F-V-L-A-V-L-F-S-N-Y-S-F-N


### FUNCTION Seems to play a role in the dimerization of PSII ### SEQUENCE -M-E-A-L-V-Y-T-F-L-L-V-S-T-L-G-I-I-F-F-A-I-F-F-R-E-P-P-K-V-P-T-K-K-M-K


### FUNCTION Seems to play a role in the dimerization of PSII ### SEQUENCE -M-E-A-L-V-Y-T-F-L-L-V-S-T-L-G-I-I-F-F-A-I-F-F-R-E-P-P-R-I-S-T-K-K-M-K


### FUNCTION Seems to play a role in the dimerization of PSII ### SEQUENCE -M-E-A-L-V-Y-T-F-L-L-V-S-T-L-G-I-I-F-F-A-I-F-F-R-E-P-P-K-V-P-N-K-K-M-K


### FUNCTION Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells ### SEQUENCE -M-Y-R-M-Q-L-L-S-C-I-A-L-S-L-A-L-I-T-N-S-A-P-T-S-S-S-T-K-K-T-Q-L-Q-L-E-H-L-L-L-D-L-Q-M-L-L-N-G-I-N-N-Y-K-N-P-K-L-T-R-M-L-T-F-K-F-Y-M-P-K-K-A-T-E-L-K-H-L-Q-C-L-E-E-E-L-K-P-L-E-E-V-L-N-L-A-Q-S-K-N-F-H-L-R-D-T-R-D-I-I-S-N-I-N-V-L-V-L-E-L-K-G-S-E-T-T-F-T-C-E-Y-D-D-D-T-A-T-I-I-E-F-L-N-G-W-I-T-F-C-Q-S-I-I-S-T-L-T


### FUNCTION Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase , that is believed not to be involved in catalysis Complex I functions in the transfer of electrons from NADH to the respiratory chain The immediate electron acceptor for the enzyme is believed to be ubiquinone ### SEQUENCE -M-W-F-E-I-L-P-G-L-S-V-M-G-V-C-L-L-I-P-G-L-A-T-A-Y-I-H-R-F-T-N-G-G-K-E-K-R-V-A-H-F-G-Y-H-W-N-L-M-E-R-D-R-R-I-S-G-V-D-R-Y-Y-V-S-K-G-L-E-N-I-D


### FUNCTION Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis They compact sperm DNA into a highly condensed, stable and inactive complex ### SEQUENCE -M-A-R-Y-R-R-C-R-S-R-S-R-C-R-R-R-R-R-R-C-H-R-R-R-R-R-C-C-R-R-R-R-R-R-R-A-C-C-R-R-Y-R-C-R-R-R


### FUNCTION Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis They compact sperm DNA into a highly condensed, stable and inactive complex ### SEQUENCE -M-A-R-Y-R-C-C-R-S-R-S-R-C-R-R-R-R-R-R-C-Y-R-R-R-R-R-C-C-R-R-R-R-R-R-V-C-C-R-R-Y-T-V-I-R-C-R-R-R


### FUNCTION Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis They compact sperm DNA into a highly condensed, stable and inactive complex ### SEQUENCE -M-A-R-Y-R-C-C-R-S-P-S-R-S-R-C-R-R-R-R-R-R-C-R-R-R-R-R-R-C-C-R-R-R-R-R-V-C-C-R-R-Y-T-V-R-C-R-R-R


### FUNCTION Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis They compact sperm DNA into a highly condensed, stable and inactive complex ### SEQUENCE -M-A-R-Y-R-C-C-R-S-Q-S-R-S-R-C-C-R-P-R-R-R-C-R-R-R-R-R-R-S-C-R-A-R-R-R-A-T-R-C-C-R-R-R-Y-R-L-R-C-R-R-Y


### FUNCTION Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis They compact sperm DNA into a highly condensed, stable and inactive complex ### SEQUENCE -M-A-R-Y-R-C-C-R-S-Q-S-R-S-R-C-C-R-R-R-R-R-C-R-R-R-R-R-R-R-C-R-A-R-R-R-A-M-R-C-C-R-R-R-Y-R-L-R-C-R-R-Y


### FUNCTION Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis They compact sperm DNA into a highly condensed, stable and inactive complex ### SEQUENCE -M-A-R-Y-R-C-C-R-S-Q-S-R-S-R-C-C-R-P-R-R-R-C-R-R-R-R-R-R-S-C-R-A-R-R-R-A-T-R-C-C-R-R-R-Y-R-L-R-S-R-R-Y


### FUNCTION Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis They compact sperm DNA into a highly condensed, stable and inactive complex ### SEQUENCE -M-A-R-Y-R-R-C-R-S-Q-S-R-S-R-C-C-R-P-R-R-R-C-R-R-R-R-R-S-C-R-A-R-R-R-A-T-R-C-C-R-R-R-Y-R-L-R-C-R-R-Y


### FUNCTION May be involved in transcriptional regulation ### SEQUENCE -M-E-T-A-L-A-E-V-Q-L-S-C-L-L-C-E-Q-T-F-D-A-T-E-K-L-D-E-H-L-P-T-H-F-P-Q-P-V-S-T-G-Q-T-C-D-I-C-G-R-T-M-R-S-S-L-E-L-H-Q-H-Y-K-R-Y-H-E-A-H-V-P-N-T-E-G-H-F-Q-C-Q-L-C-D-K-V-F-L-L-Q-D-H-L-K-V-H-V-K-I-E-H-A-T-D-G-Y-Q-P-D-E-K-S-L-D-W-Q-H-Y-S-P-R-S-L-D-T-T-N-D-Y-K-L-D-P-I-L-C-P-P-P-K-R-K-Y-P-P-R-S-P-F-F-N-P-N-L-W-L-G-A-D-N-C-F-M


### FUNCTION Component of the COP9 signalosome complex  conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity ### SEQUENCE -M-K-P-S-L-A-A-D-E-M-F-S-E-G-P-G-Y-M-E-M-D-E-S-G-G-A-T-G-M-M-M-D-H-L-P-S-N-D-K-H-V-H-A-D-F-Y-N-D-F-D-D-L-F-D-E-D-N-W-A-K-M-K-T-D-G-K-Q


### FUNCTION Colony queen number, a major feature of social organization, is associated with worker genotype for Gp-9 Colonies are headed by either a single reproductive queen ### SEQUENCE -M-K-T-F-V-L-H-I-F-I-F-A-F-V-A-F-A-S-A-S-R-D-S-A-K-K-I-G-S-Q-Y-D-N-Y-E-T-C-L-T-E-H-G-L-T-D-D-D-I-F-S-I-G-E-V-S-S-G-Q-H-K-T-N-H-E-D-T-E-L-H-K-N-G-C-V-M-Q-C-M-L-E-K-D-G-L-M-S-G-A-D-Y-D-E-E-K-M-R-E-D-Y-I-K-E-T-G-A-Q-P-G-D-Q-R-I-E-A-L-N-T-C-M-Q-E-T-K-D-M-E-D-K-C-D-K-S-L-I-L-V-A-C-V-L-A-A-E-A-V-L-A-D-S-S-E-G-A


### FUNCTION Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body ### SEQUENCE -M-Q-H-N-T-F-L-P-N-D-A-V-E-E-Q-K-Q-N-P-Y-Y-G-I-L-R-A-V-E-T-D-L-R-L-G-Q-R-W-C-E-L-K-V-H-V-L-D-I-D-L-K-T-K-R-P-L-L-S-G-I-P-V-N-G-Q-L-K-D-K-L-Q-Y-V-L-P-L-Y-L-Q-E-T-I-S-I-E-F-L-S-S-V-F-D-S-M-K-K-L-S-L-P-L-V-K-D-A-R-G-L-S-G-D-E-F-F-L-Y-L-G-I-M-C-S-D-S-T-I-V-Y-Y-K-I-T-D-G-L-I-K-P-R-Q-N-D-E-E


### FUNCTION Anticoagulant protein May prevent the complex of factors Xa  as well ### SEQUENCE -A-T-P-F-G-G-S-S-Y-E-G-H


### FUNCTION Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract  many smooth muscles ### SEQUENCE -S-N-S-K-C-P-D-G-P-D-C-F-V-G-L-M


### FUNCTION Induces relaxation of arterial smooth muscle, by targeting bradykinin receptors ### SEQUENCE -R-P-P-G-F-S-P-F-R-I-Y


### FUNCTION Induces smooth muscle contraction May target bradykinin receptors ### SEQUENCE -R-P-P-G-F-S-P-F-R-V-A-P-A-S


### FUNCTION Induces smooth muscle contraction May target bradykinin receptors ### SEQUENCE -V-P-P-G-F-T-P-F-R


### FUNCTION Hypotensive neuropeptide ### SEQUENCE -Q-E-Y-T-G-W-M-D-F


### FUNCTION Has antiplatelet activities on guinea pig, followed by human, rabbit and rat platelet-rich plasma ### SEQUENCE -D-C-A-S-G-P-C-C-R-D-C-K-F-L-E-E-G-T-I-C-N-M-A-R-G-D-D-M-D-D-Y-C-N-G-K-T-C-D-C-P-R-N-P-H-K-W-P-A-P


### FUNCTION Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta , polymerize to form an insoluble fibrin matrix Fibrin has a major function in hemostasis as one of the primary components of blood clots ### SEQUENCE -E-D-T-G-T-F-E-E-G-H-G-G-V-R


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization ### SEQUENCE -M-K-N-T-N-P-N-S-Q-P-V-E-L-N-R-T-S-L-F-L-G-R-L-L-I-F-V-L-G-I-L-F-S-S-Y-I-F-N


### FUNCTION Involved in UV protection and mutation ### SEQUENCE -M-S-T-V-Y-H-R-P-A-D-P-S-G-D-D-S-Y-V-R-P-L-F-A-D-R-C-Q-A-G-F-P-S-P-A-T-D-Y-A-E-Q-E-L-D-L-N-S-Y-C-I-S-R-P-A-A-T-F-F-L-R-A-S-G-E-S-M-N-Q-A-G-V-Q-N-G-D-L-L-V-V-D-R-A-E-K-P-Q-H-G-D-I-V-I-A-E-I-D-G-E-F-T-V-K-R-L-L-L-R-P-R-P-A-L-E-P-V-S-D-S-P-E-F-R-T-L-Y-P-E-N-I-C-I-F-G-V-V-T-H-V-I-H-R-T-R-E-L-R


### FUNCTION Possesses antimicrobial activity sensitive to inorganic cations Binds specifically to the fungal plasma membrane Has no inhibitory effect on insect gut alpha-amylase ### SEQUENCE -N-L-C-E-R-A-S-L-T-W-T-G-N-C-G-N-T-G-H-C-D-T-Q-C-R-N-W-E-S-A-K-H-G-A-C-H-K-R-G-N-W-K-C-F-C-Y-F-N-C


### FUNCTION Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions ### SEQUENCE -A-T-Y-N-I-K-L-I-T-P-E-G-T-K-E-I-T-C-S-D-S-E-Y-I-L-D-A-A-E-E-K-G-L-D-L-P-Y-S-C-R


### FUNCTION Involved in nuclear basic protein transition histones are replaced by spermatid specific proteins which are themselves replaced by protamines in late spermatids ### SEQUENCE -A-K-V-T-E-K-S-W-Q-P-Q-T-T-S-T-K-R-W-K-K-R-K-T-P-S-Q-P-R-S-R-G-K-V-R-K-I-Y-K-K-V-K-R-P-L-H-V-C-S-R-K-K-Y-S-P-K-V-I-T-T-S-R-R-Q-K-R-A-R-R-A-N-K-F-E-T-I-P


### FUNCTION Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles ### SEQUENCE -G-L-S-D-G-E-W-Q-L-V-L-N-V-W-G-K-V-E-A-D-L-A-G-H-G-Q-E-V-L-I-R-L-F-K-G-H-P-E-T-L-E-K-F-D-K-F-K-H-L-K-S-E-K-G-S-E-D-L-K-K-H-G-N-T-V-E-T-A-L-E-G-I-L-K-K-K-A-L-E-L-F-K-N-D-I-A-A-K-T-K-E-L-G-F-L-G


### FUNCTION Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals ### SEQUENCE -Q-R-T-N-D-F-I-K-A-C-G-R-E-L-V-R-V-W-V-E-I-C-G-S-V-S-W-G-R-T-A


### FUNCTION Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta , polymerize to form an insoluble fibrin matrix Fibrin has a major function in hemostasis as one of the primary components of blood clots In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway Maternal fibrinogen is essential for successful pregnancy Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage May also facilitate the immune response via both innate and T-cell mediated pathways ### SEQUENCE -A-D-G-S-D-P-A-G-G-E-F-L-A-E-G-G-G-V-R


### FUNCTION Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta , polymerize to form an insoluble fibrin matrix Fibrin has a major function in hemostasis as one of the primary components of blood clots In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway Maternal fibrinogen is essential for successful pregnancy Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage May also facilitate the immune response via both innate and T-cell mediated pathways ### SEQUENCE -T-D-T-K-E-S-D-F-L-A-E-G-G-G-V-R


### FUNCTION Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta , polymerize to form an insoluble fibrin matrix Fibrin has a major function in hemostasis as one of the primary components of blood clots In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway Maternal fibrinogen is essential for successful pregnancy Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage May also facilitate the immune response via both innate and T-cell mediated pathways ### SEQUENCE -T-D-G-K-E-G-E-F-I-A-E-G-G-G-V-R


### FUNCTION Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta , polymerize to form an insoluble fibrin matrix Fibrin has a major function in hemostasis as one of the primary components of blood clots In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway Maternal fibrinogen is essential for successful pregnancy Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage May also facilitate the immune response via both innate and T-cell mediated pathways ### SEQUENCE -T-K-T-E-G-S-F-L-A-E-G-G-G-V-R


### FUNCTION Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta , polymerize to form an insoluble fibrin matrix Fibrin has a major function in hemostasis as one of the primary components of blood clots In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway Maternal fibrinogen is essential for successful pregnancy Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage May also facilitate the immune response via both innate and T-cell mediated pathways ### SEQUENCE -T-K-D-E-G-T-F-I-A-E-G-G-G-V-R


### FUNCTION Has a vascular smooth muscle spasmogenic activity ### SEQUENCE -E-A-F-P-G-Q-S-T


### FUNCTION Bradykinins are a potent but short-lived agent of arteriolar dilation and increased capillary permeability  May cause hypotension ### SEQUENCE -A-R-P-P-G-F-S-P-F-R-I-V


### FUNCTION May be calcium-dependent and galactose-specific ### SEQUENCE -C-S-C-Y-P-D-W-M-A-I-P-G-S-G-C-Y-K-Y-V-D-T-P-K-T-F-E-E-A-E-S-T-C-R-H-F-S-P-G-P-Y-G-F-G-H-L-A-S-V-H-S-T-E-E-Y-E-A-L-A-S-M-V-P-G-A-T-D-S-W-N-P-Q-V-F-I-G-L-R-L-I-D-G-V-S-P-A-W-T-D-G-S-Y-Y-D-Y-Q-N-W-C-G-N-D-P-N-A-H-P-D-G-Y-G-A-F-S-G-G-S-Y-C-N-G-Q-W-V-D-V-H-T-F-T-N-D-Q-F-P-F-K-C-K-L-P-C-I-E


### FUNCTION Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction ### SEQUENCE -A-A-N-L-E-N-D-F-D-N-V-N-E-Q-L-Q-D-A-L-S-K-I-T-L-L-E-E-D-L-E-R-N-E-E-R-L-Q-T-A-T-E-R-L-E-E-A-S-K-Y-I-A-E-D-A-E-R-K-L-A-I-T-E-V-D-L-E-R-A-E-A-R-L-E-A-A-E-A-K-S-L-E-I-S-E-Q-E-A-S-Q-R-E-D-S-Y-E-E-T-I-R-D-L-T-Q-R-L-K-T-V-S-K-L-Q-K-E-V-D-R-L-E-D-E-L-L-A-E-K-E-K-Y-K-A-I-S-D-E-L-D-Q-T-F-A-E-L-A-G-Y


### FUNCTION ELH acts as a neurotransmitter locally, upon neurons of the abdominal ganglion and as a hormone by diffusing into the circulating hemolymph and modulating the activity of other organs It specifically causes contraction of smooth muscle in the ovotestis and expulsion of the egg string ### SEQUENCE -I-S-I-N-Q-D-L-K-A-I-T-D-M-L-L-T-E-Q-I-R-E-R-Q-R-Y-L-A-D-L-R-Q-R-L-L-E-K


### FUNCTION Vasotocin is an antidiuretic hormone ### SEQUENCE -M-S-A-M-G-W-T-L-L-A-A-A-L-L-A-I-S-A-Q-S-N-G-C-Y-I-Q-N-C-P-R-G-G-K-R-A-V-E-T-E-L-H-S-C-A-A-C-G-L-G-G-Q-C-V-G-P-S-I-C-C-G-G-L-L-G-G-G-R-G-G-G-C-I-V-G-G-P-L-S-A-P-C-K-R-E-N-L-H-P-E-P-C-R-P-G-G-G-S-S-C-G-L-E-G-I-C-A-A-P-G-I-C-C-T-D-V-T-C-S-I-D-A-T-C-D-D-V-T-E-K-A-G-V-T-F-S-G-A-T-G-G-L-A-N-P-T-G-D-L-L-R-K-V-L-L-L-A-N-A-D-L-E


### FUNCTION Water-borne pheromone that attract the marine mollusk Aplysia into breeding aggregations and coordinate male and female reproductive behavior within the aggregation ### SEQUENCE -D-Q-N-C-D-I-G-N-I-T-S-Q-C-E-M-Q-H-Q-N-C-D-D-A-N-G-C-N-T-I-I-E-E-C-K-T-S-M-V-E-R-C-Q-N-Q-E-F-E-S-A-S-G-S-T-T-L-G-P-Q


### FUNCTION Water-borne pheromone that attract the marine mollusk Aplysia into breeding aggregations and coordinate male and female reproductive behavior within the aggregation ### SEQUENCE -N-N-K-C-D-L-E-F-A-S-S-E-C-Q-M-R-Y-Q-D-C-G-E-A-S-N-C-T-A-L-I-E-E-C-K-T-S-L-Q-E-E-C-D-Q-A-S-S-E-S-S-S-T-T-I-R-P-E


### FUNCTION Water-borne pheromone that attract the marine mollusk Aplysia into breeding aggregations and coordinate male and female reproductive behavior within the aggregation ### SEQUENCE -N-N-K-C-D-I-E-F-A-T-S-E-C-E-M-R-Y-Q-D-C-G-E-A-S-S-C-T-A-L-I-E-E-C-K-T-S-L-Q-E-E-C-N-Q-A-S-S-D-E-S-S-T-T-V-R-P-E


### FUNCTION Mast cell degranulating peptide ### SEQUENCE -A-S-V-H-E-F-L-V-K


### FUNCTION Component of the abdominal endocuticle ### SEQUENCE -Q-K-P-G-E-A-V-I-L-E-Q-S-I-D-N-D-G-L-G-Q-Y-T-F-G-F-K-T-S-D-G-L-I-R-Q-E-Q-G-V-V-K-N-Q-G-T-E-N-E-A-L-E-V-R-G-T-I-T-W-L-G-A-D-G-K-D-Y-S-I-N-F-V-A-D-E-N-G-F-Q-P-Q-Y-T-Q


### FUNCTION Component of the abdominal endocuticle ### SEQUENCE -Q-V-P-F-A-P-R-P-V-I-P-G-A-F-V-P-I-V-S-Q-N-F-D-L-N-G-V-D-G-S-Y-T-F-S-Y-E-S-A-D-G-S-A-R-Q-E-S-G-V-V-N-A-P-G-T-P-L-E-A-Q-A-V-Q-G-S-Y-T-Y-V-G-T-D-G-V-P-V-Q-V-N-Y-V-A-D-E-N-G-F-Q-P-V-G-N-V-V-A-P-A-I-S-R-A-V-A-A-Q-V-A-Q-A-R-A-E-G-P-I-L-P-G-V-P-T-P-I-P-F-R-G-R-P-F


### FUNCTION Component of the abdominal endocuticle ### SEQUENCE -Q-A-P-P-D-K-V-I-P-I-I-S-Q-N-E-V-R-N-P-D-G-S-Y-Q-W-N-Y-E-T-G-N-G-I-K-A-D-E-T-G-T-L-K-K-G-S-K-P-D-E-G-D-F-I-V-A-Q-G-S-F-S-Y-T-G-P-D-G-T-A-Y-S-V-Q-Y-Q-A-D-D-E-N-G-F-V-P-Q-G-A-H-F-P-T-P-P-P-I-P-P-A-I-Q-R-A-L-D-Y-L-A-T-L-P-S-T-P-E-P-R-P


### FUNCTION Component of the abdominal endocuticle ### SEQUENCE -Q-F-G-N-Y-Y-Q-P-Q-P-T-Y-S-P-P-A-R-Q-Q-V-P-I-L-Q-Y-S-N-E-V-N-P-D-G-S-Y-A-Y-S-Y-Q-T-G-N-G-I-A-A-Q-E-Q-G-Y-L-K-N-P-G-Q-R-D-L-E-A-E-N-V-Q-G-T-F-S-Y-T-A-P-D-G-T-P-I-S-L-R-Y-V-A-D-E-N-G-F-R-A-E-G-A-H-L-P-T-P-P-P-I-P-E-A-I-A-R-S-L-E-V-I-A-R-T-P-Q-Q-P-F-Q-P-Q-P-Q-Y-N-P-F-R-R-F


### FUNCTION Specifically inhibits an intracellular serine proteinase ### SEQUENCE -S-A-G-K-F-I-V-I-F-K-N-G-V-S-D-D-K-I-R-E-T-K-D-E-V-I-A-E-G-G-T-I-T-N-E-Y-N-M-P-G-M-K-G-F-A-G-E-L-T-P-Q-S-L-T-K-F-Q-G-L-Q-G-D-L-I-D-S-I-E-E-D-G-I-V-T-T-Q