### FUNCTION E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage ### SEQUENCE -M-E-G-W-D-K-G-T-K-S-V-V-G-E-I-P-L-L-S-T-R-A-G-P-R-D-G-E-A-W-R-Q-R-L-K-E-E-Y-R-A-L-I-A-Y-T-S-V-N-K-S-K-D-N-D-W-F-R-I-S-A-A-N-P-E-G-T-R-W-E-G-T-C-W-Y-V-H-N-L-R-R-Y-E-F-P-L-Q-F-D-I-P-V-A-Y-P-Q-V-A-P-E-I-E-L-P-T-L-D-G-K-T-H-K-M-Y-R-G-G-K-I-C-L-T-V-H-F-K-P-L-W-A-K-N-C-P-R-F-G-I-A-H-A-L-C-L-G-L-A-P-W-L-A-A-E-V-P-I-L-V-D-S-G-M-V-K-H-K-D-D-E-A-A-P-A-D-A-A-A-A-A-S-G-S-A-A-A-S


### FUNCTION May play a role during anther development ### SEQUENCE -M-A-D-C-T-T-M-R-L-A-S-S-V-T-I-I-L-L-L-L-V-A-S-Q-A-L-V-V-S-G-E-S-S-S-S-A-M-Q-S-K-T-L-N-M-N-K-L-L-N-I-S-E-D-H-S-P-N-G-G-R-H-W-M-Q-R-M-Q-P-D-S-C-S-E-Q-N-V-V-V-Y-Q-N-N-A-E-H-L-P-S-G-I-P-T-Y-S-V-E-I-I-N-V-C-T-A-C-T-V-Y-D-V-H-I-S-C-G-E-F-A-S-A-E-L-V-D-P-S-Q-F-Q-R-I-G-F-N-D-C-L-V-K-G-G-G-R-L-G-P-S-E-A-V-S-F-Q-Y-S-N-S-F-A-Y-P-L-A-V-A-N-V-A-C-E


### FUNCTION Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles ### SEQUENCE -M-E-G-D-T-I-S-R-M-M-G-S-G-V-Q-M-D-G-K-I-L-Q-T-F-E-K-S-F-V-Q-V-Q-N-I-L-D-H-N-R-L-L-I-N-E-I-N-Q-N-H-E-S-K-I-P-D-N-L-G-R-N-V-G-L-I-R-E-L-N-N-N-V-R-R-V-A-H-L-Y-V-D-L-S-N-N-F-S-K-S-M-E-A-S-S-E-G-D-S-S-E-G-R-G-N-R-R-I-R-P-A


### FUNCTION Promotes cellular proliferation and expansion ### SEQUENCE -M-G-Y-S-S-S-S-R-I-G-L-C-L-F-L-F-F-T-F-A-L-L-S-S-A-R-I-S-L-S-F-S-E-N-E-M-T-V-V-P-E-R-S-L-M-V-S-T-N-D-Y-S-D-P-T-A-N-G-R-H-D-P-P-R-G-G-R-G-R-R-R


### FUNCTION Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites ### SEQUENCE -M-A-S-S-S-S-L-T-R-S-G-S-V-H-L-D-E-K-W-K-L-S-K-K-D-G-G-A-S-R-I-T-R-S-S-S-T-S-S-S-S-F-N-G-K-K-Q-G-R-C-A-F-T-R-K-C-A-R-L-V-K-E-Q-R-A-R-F-Y-I-M-R-R-C-V-I-M-L-I-C-W-R-D-N-Y-S-D-S


### FUNCTION May be involved in cadmium resistance ### SEQUENCE -M-K-E-K-K-G-H-Y-V-P-P-S-Y-I-P-L-T-Q-S-D-A-D-T-E-V-E-T-T-T-P-N-L-E-I-A-V-S-E-S-T-K-D-D-P-R-Q-W-S-S-G-I-C-A-C-F-D-D-M-Q-S-C-C-V-G-L-F-C-P-C-Y-I-F-G-K-N-A-E-L-L-G-S-G-T-F-A-G-P-C-L-T-H-C-I-S-W-A-L-V-N-T-I-C-C-F-A-T-N-G-A-L-L-G-L-P-G-C-F-V-S-C-Y-A-C-G-Y-R-K-S-L-R-A-K-Y-N-L-Q-E-A-P-C-G-D-F-V-T-H-F-F-C-H-L-C-A-I-C-Q-E-Y-R-E-I-R-E-Q-S-S-G-S-Y-P-L-D-M-K-M-A-I-T-N-A-P-L-A-Q-T-M-E-S-A-N


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-L-K-K-K-K-T-E-V-Y-A-L-G-E-H-I-S-M-S-A-D-K-A-R-R-V-I-D-Q-I-R-G-R-S-Y-E-E-T-L-M-I-L-E-L-M-P-Y-R-A-C-Y-P-I-L-K-L-V-Y-S-A-A-A-N-A-S-Y-N-M-G-S-S-E-A-N-L-V-I-S-K-A-E-V-N-G-G-T-T-V-K-K-L-K-P-R-A-R-G-R-S-F-P-I-K-R-S-T-C-H-I-T-I-V-M-K-D-I-S-L-N-D-E-Y-V-K-M-N-S-L-K-K-T-R-W-K-K-K-S-T-A-M-T-Y-H-D-M-Y-N-S-G-G-L-W-D-K-K


### FUNCTION Binds to 23S rRNA ### SEQUENCE -M-I-Q-P-Q-T-H-L-N-V-A-D-N-S-G-A-R-E-L-M-C-I-R-I-I-G-A-S-N-R-R-Y-A-H-I-G-D-V-I-V-A-V-I-K-E-A-V-P-N-M-P-L-E-R-S-E-I-V-R-A-V-I-V-R-T-C-K-E-L-K-R-D-N-G-M-I-I-R-Y-D-D-N-A-A-V-V-I-D-Q-E-G-N-P-K-G-T-R-I-F-G-A-I-A-R-E-L-R-E-L-N-F-T-K-I-V-S-L-A-P-E-V-L


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-G-R-D-T-I-A-E-I-I-T-S-I-R-N-A-D-M-D-R-K-R-V-V-R-I-A-S-T-N-I-T-E-N-I-V-Q-I-L-L-R-E-G-F-I-E-N-V-R-K-H-Q-E-N-N-K-Y-F-L-V-L-T-L-R-H-R-R-N-K-K-R-P-Y-R-N-I-L-N-L-K-R-I-S-R-P-G-L-R-I-Y-S-N-Y-Q-R-I-P-R-I-L-G-G-M-G-I-V-I-L-S-T-S-R-G-I-M-T-D-R-E-A-R-L-E-G-I-G-G-E-I-L-C-Y-I-W


### FUNCTION Seems to play a role in the dimerization of PSII ### SEQUENCE -M-E-A-L-V-Y-T-F-L-L-V-S-T-L-G-I-I-F-F-A-I-F-F-R-E-P-P-K-L-P-T-K-K-N


### FUNCTION May help in the organization of the PsaE and PsaF subunits ### SEQUENCE -M-R-D-L-K-T-Y-L-S-V-A-P-V-L-S-T-L-W-F-V-A-L-A-G-L-L-I-E-I-N-R-F-F-P-D-A-L-T-F-P-F-F


### FUNCTION Seems to be required for the assembly of the photosystem I complex ### SEQUENCE -M-T-W-R-S-E-H-I-W-I-E-L-I-T-G-S-R-K-I-S-N-F-C-W-A-F-I-L-F-L-G-S-L-G-F-L-L-V-G-T-S-S-Y-L-G-R-N-L-I-S-F-F-P-T-Q-Q-I-V-F-F-P-Q-G-I-V-M-S-F-Y-G-I-A-G-L-F-I-S-S-Y-L-W-C-T-I-S-W-N-V-G-S-G-Y-D-R-F-D-R-K-E-G-I-V-C-I-F-R-W-G-F-P-G-K-N-R-R-I-F-L-R-F-L-I-K-D-I-Q-S-V-R-I-E-V-K-E-G-I-S-A-R-R-V-L-Y-M-D-I-R-G-Q-G-S-I-P-L-T-R-T-D-E-N-L-T-P-R-E-I-E-Q-K-A-A-E-L-A-Y-F-L-R-V-P-I-E-V-F


### FUNCTION Produces ATP from ADP in the presence of a proton gradient across the membrane ### SEQUENCE -M-T-L-N-L-S-V-L-T-P-N-R-I-V-W-D-S-E-V-E-E-I-V-L-S-T-N-S-G-Q-I-G-I-L-S-N-H-A-P-I-A-T-A-V-D-I-G-I-L-R-I-R-L-N-D-Q-W-L-T-M-A-L-M-G-G-F-A-R-I-G-N-N-E-I-T-V-L-V-N-D-A-E-K-G-S-D-I-D-P-Q-E-A-Q-Q-T-L-E-I-A-E-A-N-V-K-K-A-E-G-R-R-Q-K-I-E-A-N-L-A-L-R-R-A-R-T-R-V-E-A-I-N-P-I-S


### FUNCTION Essential for the assembly of the photosystem I  complex May act as a chaperone-like factor to guide the assembly of the PSI subunits ### SEQUENCE -M-P-R-S-R-I-N-G-N-F-I-D-Q-T-F-S-I-V-A-N-I-L-L-R-V-I-P-T-T-S-G-E-K-E-A-F-T-Y-Y-R-D-G-M-S-A-Q-S-E-G-N-Y-A-E-A-L-Q-N-Y-Y-E-A-M-R-L-E-I-D-P-Y-D-R-S-Y-I-L-Y-N-I-G-L-I-H-T-S-N-G-E-H-T-K-A-L-E-Y-Y-F-R-A-L-E-R-N-P-F-L-P-Q-A-F-N-N-M-A-V-I-C-H-Y-R-G-E-Q-A-I-Q-Q-G-D-S-E-I-A-E-A-W-F-D-Q-A-A-E-Y-W-K-Q-A-I-A-L-T-P-G-N-Y-I-E-A-H-N-W-L-K-I-T-R-R-F-E


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-K-N-V-T-D-S-F-V-S-L-G-H-W-P-S-A-G-S-F-G-F-N-T-D-I-L-A-T-N-P-I-N-L-S-V-V-L-G-V-L-I-F-F-G-K-G-V-L-S-D-L-L-D-N-R-K-Q-R-I-L-N-T-I-R-N-S-E-E-L-R-E-G-A-I-E-Q-L-E-K-A-R-S-R-L-R-K-V-E-T-E-A-E-Q-F-R-V-N-G-Y-S-E-I-E-R-E-K-L-N-L-I-N-S-T-Y-K-T-L-E-Q-L-E-N-Y-K-N-E-T-I-Q-F-E-Q-Q-R-A-I-N-Q-V-R-Q-R-V-F-Q-Q-A-L-R-G-A-L-G-T-L-N-S-C-L-N-N-E-L-H-L-R-T-I-S-A-N-I-G-M-L-G-T-M-K-E-I-T-D


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation ### SEQUENCE -M-L-N-T-F-S-L-I-G-I-C-L-N-S-T-L-Y-S-S-S-F-F-F-G-K-L-P-E-A-Y-A-F-L-N-P-I-V-D-I-M-P-V-I-P-L-F-F-F-L-L-A-F-V-W-Q-A-A-V-S-F-R


### FUNCTION Involved in the transport of copper ### SEQUENCE -M-L-S-S-K-N-V-V-V-V-E-A-W-N-T-T-T-T-T-Q-T-Q-T-P-H-R-P-S-L-L-H-P-T-F-Y-W-G-Y-N-C-Q-V-L-F-S-G-W-P-G-S-D-R-G-M-Y-A-L-A-L-I-F-V-F-F-L-A-F-L-A-E-W-L-A-R-C-S-D-A-S-S-I-K-Q-G-A-D-K-L-A-K-V-A-F-R-T-A-M-Y-T-V-K-S-G-F-S-Y-L-V-I-L-A-V-V-S-F-N-G-G-V-F-L-A-A-I-F-G-H-A-L-G-F-A-V-F-R-G-R-A-F-R-N-R-D-I-Q


### FUNCTION Binds to actin and affects the structure of the cytoskeleton At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations By binding to PIP2, it inhibits the formation of IP3 and DG ### SEQUENCE -M-S-W-Q-T-Y-V-D-D-H-L-M-C-E-V-D-G-N-P-G-Q-Q-L-S-A-A-A-I-I-G-H-D-G-S-V-W-A-Q-S-S-T-F-P-K-F-K-P-E-E-I-T-G-I-M-K-N-F-D-E-P-G-H-L-A-P-T-G-L-Y-L-G-G-T-K-Y-M-V-I-Q-G-E-P-I-A-V-I-R-G-K-K-G-S-G-G-V-T-I-K-K-T-G-Q-A-L-V-F-G-V-Y-D-E-P-V-T-P-G-Q-C-N-L-I-V-E-R-L-G-D-Y-L-I-E-Q-G-L


### FUNCTION Actin-depolymerizing protein Severs actin filaments ### SEQUENCE -M-S-F-R-G-L-N-A-S-S-G-M-G-V-A-D-H-S-K-N-T-F-L-E-L-K-R-K-K-V-H-R-Y-V-I-F-K-I-D-E-K-K-K-E-V-V-V-E-K-T-G-G-P-A-E-S-F-D-E-F-A-A-A-L-P-E-N-D-C-R-Y-A-V-Y-D-F-D-F-V-T-S-E-N-C-Q-K-S-K-I-F-F-I-A-W-S-P-D-S-S-R-I-R-A-K-M-L-Y-A-T-S-K-E-R-F-R-R-E-L-D-G-V-H-Y-E-I-Q-A-T-D-P-T-E-M-D-L-E-V-L-R-E-R-A-H


### FUNCTION Potent plasminogen activator that converts plasminogen into plasmin It forms a 11 complex with plasmin, which in turn activates other plasminogen molecules ### SEQUENCE -M-L-K-R-S-L-L-F-L-T-V-L-L-L-L-F-S-F-S-S-I-T-N-E-V-S-A-S-S-S-F-D-K-G-K-Y-K-K-G-D-D-A-S-Y-F-E-P-T-G-P-Y-L-M-V-N-V-T-G-V-D-G-K-G-N-E-L-L-S-P-H-Y-V-E-F-P-I-K-P-G-T-T-L-T-K-E-K-I-E-Y-Y-V-E-W-A-L-D-A-T-A-Y-K-E-F-R-V-V-E-L-D-P-S-A-K-I-E-V-T-Y-Y-D-K-N-K-K-K-E-E-T-K-S-F-P-I-T-E-K-G-F-V-V-P-D-L-S-E-H-I-K-N-P-G-F-N-L-I-T-K-V-I-I-E-K-K


### FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase ### SEQUENCE -M-S-L-T-L-V-L-F-L-I-G-I-L-G-F-V-F-N-R-K-N-I-I-L-M-L-I-S-I-E-I-M-L-L-S-I-T-F-L-I-L-V-S-S-I-N-L-D-D-I-I-G-Q-T-Y-A-I-Y-I-I-V-V-A-G-A-E-S-A-I-G-L-A-I-L-V-A-F-Y-R-L-R-G-S-I-A-I-E-Y-K


### FUNCTION Controls the interaction of photosystem II  cores with the light-harvesting antenna ### SEQUENCE -N-G-W-N-D-N-K-T-F-I-L-I-G-S-A-S-W-A-A-L-V-L-L-V-G-S-L-N-S-F-V-I


### FUNCTION Controls the interaction of photosystem II  cores with the light-harvesting antenna ### SEQUENCE -N-G-W-N-E-N-K-N-F-I-L-L-G-A-V-T-W-A-I-L-V-F-I-V-G-S-L-N-S-Y-V-I


### FUNCTION Controls the interaction of photosystem II  cores with the light-harvesting antenna ### SEQUENCE -N-S-W-E-N-N-K-N-I-I-F-S-G-S-L-I-W-V-F-L-L-I-I-V-G-F-L-N-Y-L-V-V


### FUNCTION Controls the interaction of photosystem II  cores with the light-harvesting antenna ### SEQUENCE -N-G-W-N-D-N-K-N-F-V-L-F-G-A-A-A-W-I-G-L-V-L-L-V-G-T-L-Y-Y-F-V-V


### FUNCTION Controls the interaction of photosystem II  cores with the light-harvesting antenna ### SEQUENCE -N-G-W-N-E-N-K-N-Y-I-L-I-G-S-A-A-W-A-G-L-V-L-L-V-G-T-L-N-Y-L-V-I


### FUNCTION Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase , that is believed not to be involved in catalysis Complex I functions in the transfer of electrons from NADH to the respiratory chain The immediate electron acceptor for the enzyme is believed to be ubiquinone ### SEQUENCE -M-W-F-E-I-L-P-G-L-S-V-M-G-V-C-L-L-I-P-G-L-A-T-A-Y-I-H-R-F-T-N-G-G-K-E-K-R-V-A-H-F-G-Y-H-W-N-L-M-E-R-D-R-R-I-S-G-V-D-R-Y-Y-V-S-K-G-L-E-N-I-D


### FUNCTION Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase , that is believed not to be involved in catalysis but required for the complex assembly Complex I functions in the transfer of electrons from NADH to the respiratory chain The immediate electron acceptor for the enzyme is believed to be ubiquinone ### SEQUENCE -M-V-P-R-R-N-P-E-P-L-R-F-L-P-D-E-S-R-S-L-P-P-P-K-L-T-D-P-R-L-L-Y-V-G-F-L-G-Y-C-A-G-L-V-D-N-F-I-H-R-R-P-I-R-S-A-G-L-H-R-H-L-L-Y-I-T-A-F-Y-F-V-G-Y-Y-L-V-K-R-G-D-Y-T-Y-A-V-R-D-R-E-M-F-G-Y-M-K-L-H-P-E-D-F-S-E-K-E-K-K-T-Y-A-E-I-F-E-K-F-H-P-I-R


### FUNCTION Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase , that is believed not to be involved in catalysis Complex I functions in the transfer of electrons from NADH to the respiratory chain The immediate electron acceptor for the enzyme is believed to be ubiquinone ### SEQUENCE -M-W-F-E-I-L-P-G-I-A-V-M-G-T-C-L-V-I-P-G-L-A-T-A-Y-I-H-R-F-T-N-G-G-K-E-K-R-V-A-H-F-V-Y-H-W-D-L-M-E-R-D-R-H-I-S-G-V-N-R-Y-Y-V-S-K-G-L-E-N-I-D


### FUNCTION Component of the class I major histocompatibility complex ### SEQUENCE -M-S-P-S-V-A-L-A-V-L-A-L-L-S-L-S-G-L-E-A-I-Q-R-T-P-K-I-Q-V-Y-S-R-H-P-P-E-N-G-K-P-N-F-L-N-C-Y-V-S-G-F-H-P-S-D-I-E-V-D-L-L-K-N-G-E-K-M-G-K-V-E-H-S-D-L-S-F-S-K-D-W-S-F-Y-L-L-Y-Y-T-E-F-T-P-N-E-K-D-E-Y-A-C-R-V-N-H-V-T-L-S-G-P-R-T-V-K-W-D-R-D-M


### FUNCTION Receptor for gonadotropin releasing hormone  This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system ### SEQUENCE -V-A-F-A-T-S-F-T-V-C-W-T-P-Y-Y-V-L-G-I-W-Y-W-F-D-P-E-M-L-N-R-V-S-D-P-V-N-H-F-F-F-L-F-A-F-L-N-P-C-F-D-P-L-I-Y-G-Y-F-S-L


### FUNCTION Has a low ribonuclease activity ### SEQUENCE -M-A-P-A-R-E-G-C-C-P-L-L-L-L-L-L-L-G-L-W-V-A-E-I-P-V-S-A-K-P-E-G-M-T-S-S-Q-W-F-N-T-Q-H-V-Q-P-S-P-Q-A-C-D-S-A-M-R-D-I-N-K-H-T-K-R-C-K-D-L-N-T-F-L-H-K-P-F-S-S-V-A-A-T-C-Q-T-P-N-I-T-C-K-N-G-H-K-N-C-H-Q-S-H-R-P-V-S-L-T-M-C-G-L-T-S-G-K-Y-P-N-C-R-Y-K-E-E-H-Q-N-K-S-Y-V-V-A-C-E-P-P-Q-Q-G-D-P-E-H-S-L-V-P-V-H-F-D-K-V-V


### FUNCTION Has a low ribonuclease activity ### SEQUENCE -M-A-P-A-R-A-G-C-C-P-L-L-L-L-L-L-G-L-W-V-A-Q-I-P-V-S-A-K-P-K-D-M-T-S-S-Q-W-F-K-T-Q-H-V-Q-P-S-P-E-A-C-Y-L-A-M-S-N-I-S-K-Y-I-E-W-C-K-D-L-N-T-F-L-H-E-P-F-S-S-V-A-T-T-C-Q-T-P-N-I-A-C-K-N-G-H-K-N-C-H-Q-S-S-G-P-M-S-L-T-M-C-E-L-T-S-G-K-Y-P-N-C-R-Y-K-E-K-H-L-N-A-P-Y-I-V-A-R-D-P-P-Q-Q-G-D-P-G-Y-P-L-V-P-V-H-L-D-K-V-V


### FUNCTION Has a low ribonuclease activity ### SEQUENCE -M-A-P-A-R-A-G-C-C-P-L-L-L-L-L-L-G-L-R-V-A-Q-I-P-V-S-A-K-P-K-D-M-T-S-S-Q-W-F-K-T-Q-H-V-Q-P-S-P-E-A-C-Y-S-A-M-S-N-I-S-K-Y-I-E-W-C-K-D-L-N-T-F-L-H-E-P-F-S-S-V-A-T-T-C-Q-T-P-N-I-A-C-K-N-R-H-K-N-C-H-Q-S-S-G-P-M-S-L-T-M-C-E-L-T-S-G-K-Y-P-N-C-R-Y-K-E-K-H-L-N-A-P-Y-I-V-A-C-D-P-P-Q-Q-G-D-P-G-Y-P-L-V-P-V-H-L-D-K-V-V


### FUNCTION Binds specifically to the 3'-terminal U-tract of U6 snRNA ### SEQUENCE -M-L-D-P-F-C-F-L-K-M-Y-L-K-E-R-V-E-V-K-T-K-S-G-E-A-Y-T-G-T-L-E-G-F-D-E-H-I-N-L-M-L-T-C-S-S-V-E-G-S-E-D-K-V-L-F-L-R-G-E-N-I-L-F-V-G-P-R-L-L-L


### FUNCTION Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA Required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA ### SEQUENCE -M-L-F-Y-E-F-F-R-S-S-I-G-S-R-V-S-V-M-L-K-A-G-V-Y-V-S-G-R-L-G-G-I-D-P-Y-L-N-L-S-L-L-D-V-R-I-L-S-S-H-P-G-L-S-S-I-S-V-C-S-I-R-G-S-S-I-K-Y-I-L-V-D-K-D-A-K-L-L-Q-G-V-N-A-G-S-R-L-R-M-I-L-D-K-C-Y


### FUNCTION Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane It must be involved intimately in the translocation of a wide variety of protein substrates ### SEQUENCE -M-E-S-K-H-F-C-L-Y-P-I-Y-M-D-S-A-R-S-L-S-E-G-R-K-Y-R-K-E-I-C-V-Q-R-P-R-Y-H-E-I-K-N-A-L-E-K-L-E-I-E-Y-T-D-E-P-S-K-K-H-P-R-D-F-F-N-S-G-R-F-R-I-K-K-E-Y-G-R-L-F-V-I-E-G-I-S-Q-T-I-A-E-L-R-S-K-P-G-S-S-E-E-T-S-R-E-K-Q-S-R-G-K-A-V-H-G-V-V-Q-N-G-V-Y-V-E-N-K-L-N-L-V-R-K-K-K-A-K-K-K-K


### FUNCTION The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins ### SEQUENCE -M-N-L-F-D-I-E-G-L-L-V-A-D-S-Q-G-E-I-L-Y-R-R-V-F-S-K-E-E-E-I-A-A-K-I-A-E-K-A-A-G-D-R-E-S-I-S-M-F-Y-D-R-I-V-M-C-K-R-L-D-E-V-L-L-I-I-Y-S-P-M-D-V-N-E-P-F-V-G-Q-V-F-D-E-F-T-A-A-F-I-G-I-V-K-T-P-T-R-E-R-V-W-K-K-Y-D-Q-I-V-L-L-V-A-E-F-L-Y-E-G-I-V-M-S-G-K-S-D-E-M-L-D-K-L-P-K-R-N-F-E-G-V-D-G-M-K-V-P-R-G-F-A-S-F-L-H-K-A-T-K-S-L-S-I-G-S-N-K


### FUNCTION Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus It is essential for the regulated turnover of proteins and for the removal of misfolded proteins The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH It has an ATP-dependent proteolytic activity ### SEQUENCE -M-D-S-S-I-G-I-K-G-R-N-F-A-I-V-A-A-D-T-K-I-S-S-S-I-L-V-V-K-E-N-H-E-K-F-Q-V-I-K-D-R-I-V-M-A-M-T-G-N-Q-G-D-A-F-R-T-M-L-Y-V-S-E-S-A-L-Y-E-E-I-Q-N-G-I-E-L-S-P-S-V-L-A-H-M-I-Q-N-K-V-H-E-S-L-R-R-R-Q-L-D-I-S-S-I-V-A-G-R-G-P-E-K-Y-D-L-W-S-V-D-K-Y-G-A-I-S-S-V-P-F-C-A-S-G-Y-A-A-Y-F-V-Y-G-I-L-D-R-E-Y-S-E-D-I-T-I-D-A-A-L-S-I-M-Q-K-C-V-N-L-L-K-E-R-L-M-I-N-L-E-G-F-M-V-K-I-V-T-D-D-G-I-L-T-R-T-L-V-P-E-I-K-G


### FUNCTION Plays an important role in the elongation step of protein synthesis ### SEQUENCE -M-E-Y-V-A-A-Y-V-M-F-D-K-V-G-K-E-L-N-E-R-S-M-T-E-L-F-N-E-I-G-A-E-I-E-P-E-T-M-R-L-F-L-S-K-V-S-G-K-S-M-D-E-V-M-S-K-G-K-E-L-M-A-S-L-A-I-S-S-S-Q-K-S-E-P-A-Q-P-A-D-T-A-E-S-T-Q-A-T-E-N-K-E-E-E-D-E-D-F-D-I-F-A-A-F


### FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively Pol II is the central component of the basal RNA polymerase II transcription machinery Pols are composed of mobile elements that move relative to each other In Pol II, RBP10 is part of the core element with the central large cleft ### SEQUENCE -M-I-I-P-I-R-C-F-T-C-G-K-E-I-S-S-K-W-E-P-Y-Q-E-L-L-K-I-D-K-G-K-A-E-A-L-D-E-L-G-M-R-R-I-C-C-R-R-M-F-L-G-H-V-D-I-V-D-K-L-L-K-F-D-I-V-K-D-F-T-Q-R-S


### FUNCTION Necessary for protein translocation in the endoplasmic reticulum ### SEQUENCE -M-S-Q-K-L-Q-K-P-S-F-L-S-E-Y-L-R-S-I-R-L-F-S-K-K-C-V-R-P-S-G-K-E-L-S-M-S-I-K-R-H-A-I-G-I-G-F-L-G-I-L-G-Y-A-I-K-L-I-H-I-P-I-N-N-I-I-V-S-S-P-G-K-E


### FUNCTION Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione ### SEQUENCE -M-E-R-G-M-E-S-E-A-F-Y-G-L-S-A-R-G-W-D-G-S-E-V-S-L-G-S-F-R-G-C-V-I-M-I-A-N-V-A-S-S-C-K-F-A-E-S-N-Y-K-S-F-A-G-L-L-D-K-F-Y-R-K-G-L-R-I-L-L-F-P-C-N-Q-Y-L-G-Q-E-S-R-P-I-E-E-I-R-G-E-V-S-K-K-Y-S-D-R-F-V-V-F-D-K-V-D-V-F-G-K-G-A-H-P-V-F-R-H-L-V-N-T-K-N-G-K-G-R-L-G-N-F-I-K-W-N-F-T-K-F-L-V-D-R-K-G-C-V-V-K-R-F-G-P-S-D-I-V-K-E-D-D-E-N-L-L-R-S-I-E-D-G-E-N-G-M-Q-N-S


### FUNCTION Functions as a component of the DNA-binding general transcription factor complex TFIID May also function as a component of transcription regulatory histone acetyl transferase ### SEQUENCE -M-A-S-G-E-N-L-A-P-R-D-A-K-V-I-S-V-I-L-R-S-L-G-I-E-E-C-E-P-K-V-I-I-Q-L-L-E-F-A-Y-R-Y-T-T-D-V-L-E-D-A-L-L-F-A-K-H-T-G-R-T-H-I-T-T-S-D-V-K-L-A-L-Q-T-K-V-G-R-H-F-V-P-P-P-P-R-Q-Y-L-S-E-I-S-T-M-V-N-S-K-P-L-T-I-P-D-G-E-N-L-I-R-V-P-P-S-S-S-A-L-L-N-L-D-Y-E-V-L-R-K-D-S-D-K-K-R-R-I-Y


### FUNCTION Seems to be involved in N-acetylation ### SEQUENCE -M-T-T-I-R-R-F-V-C-D-D-L-F-K-F-N-N-I-N-L-D-Y-L-T-E-T-Y-Y-L-P-F-Y-L-Q-Y-L-S-K-W-P-S-L-L-S-M-A-E-D-V-N-G-K-P-M-G-Y-M-I-G-K-A-E-G-E-G-I-N-W-H-G-H-V-T-A-V-S-V-A-P-E-F-R-R-I-G-L-A-D-R-L-M-H-I-L-E-E-G-S-E-K-I-Y-D-G-Y-F-V-D-L-F-V-R-K-S-N-T-L-A-I-N-M-Y-T-K-F-G-Y-S-V-Y-R-T-V-I-G-Y-Y-S-G-D-E-D-A-L-D-M-R-K-A-L-P-R-D-V-E-K-K-S-I-I-P-L-K-H-P-V-Y-P-T-D-A-D-L


### FUNCTION Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca complex are a number of protein kinases and phosphatases ### SEQUENCE -M-S-Q-E-L-T-I-N-A-D-Q-L-T-E-E-Q-I-A-E-F-K-E-A-F-S-L-F-D-K-D-G-D-G-T-I-T-T-K-E-L-G-T-V-M-R-S-L-G-Q-N-P-T-E-A-E-L-Q-D-M-I-N-E-V-D-A-D-G-N-G-T-I-D-F-P-E-F-L-T-M-M-A-R-K-M-K-D-T-D-S-E-E-E-I-R-E-A-F-R-V-F-D-K-D-G-N-G-F-I-S-A-A-E-L-R-H-V-M-T-N-L-G-E-K-L-T-D-E-E-V-D-E-M-I-R-E-A-D-I-D-G-D-G-Q-V-N-Y-E-E-F-V-T-M-M-T-S-K


### FUNCTION Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions ### SEQUENCE -M-G-R-R-R-V-K-R-R-I-N-I-P-K-R-Q-S-R-L-E-K-R-F-N-C-P-V-C-N-H-E-N-V-V-Q-C-T-V-K-K-T-L-M-K-G-F-A-N-C-S-V-C-E-A-S-F-A-C-D-A-N-K-L-T-T-G-I-D-V-Y-S-A-W-V-D-E-C-C-K-R


### FUNCTION May play a role in vesicular transport from endoplasmic reticulum to Golgi ### SEQUENCE -M-K-R-E-V-P-V-S-T-M-S-Y-L-V-C-G-M-I-E-Y-L-M-E-Q-R-S-D-I-E-A-D-L-K-S-I-G-Y-E-V-G-I-K-L-L-E-L-C-N-F-E-R-E-V-R-I-S-T-L-L-Y-R-A-T-F-D-L-L-S-L-V-S-D-S-D-R-R-V-E-K-A-R-D-V-D-R-T-Y-L-L-T-D-S-D-G-L-F-S-R-F-I-S-V-P-D-E-W-N-G-L-S-A-D-S-I-V-C-G-M-I-Q-A-A-L-M-A-S-G-Y-D-S-E-V-T-A-F-P-E-P-S-E-N-L-P-N-R-V-I-F-Q-I-R-I-L-D-L


### FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors ### SEQUENCE -M-S-G-S-R-F-E-R-E-L-E-F-V-Q-L-L-C-N-P-D-Y-L-R-W-L-T-R-E-G-H-F-E-S-E-E-F-R-S-Y-L-R-Y-L-E-Y-W-R-S-P-E-Y-S-R-F-L-T-Y-P-Q-C-L-A-V-L-E-H-L-N-S-E-N-I-N-D-M-L-S-D-E-N-F-F-L-A-L-G-E-Q-Q-Y-F-I-W-L-N-K-H-K-E-G-W-N-K


### FUNCTION Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase Reduces low molecular weight disulfides and proteins ### SEQUENCE -M-K-A-V-L-L-A-L-A-L-V-Y-G-S-Q-G-T-E-Y-G-G-G-K-M-T-E-A-D-Y-G-E-M-V-R-R-E-K-C-I-M-F-V-K-R-F-C-P-Y-S-I-R-A-R-E-L-L-H-D-R-G-V-G-C-K-I-I-E-V-D-N-N-L-D-A-Y-S-F-A-K-R-N-H-S-T-F-P-V-F-F-L-D-G-D-L-V-E-G-G-C-E-K-L-L-V-L-S-D-S-N-L-P-P-F-D-K-S-P-L-L-T-Q-N-R-E-P-V-L-L-D


### FUNCTION Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions ### SEQUENCE -M-D-M-F-S-A-P-D-R-I-P-E-Q-I-R-I-F-F-K-T-M-K-Q-V-V-P-A-K-A-V-C-G-S-T-V-L-D-V-A-H-K-N-G-V-D-L-E-G-A-C-E-G-N-L-A-C-S-T-C-H-V-I-L-E-E-P-L-Y-R-K-L-G-E-P-S-D-K-E-Y-D-L-I-D-Q-A-F-G-A-T-G-T-S-R-L-G-C-Q-L-R-V-D-K-S-F-E-N-A-V-F-T-V-P-R-A-T-K-N-M-A-V-D-G-F-K-P-K-P-H


### FUNCTION The GINS complex plays an essential role in the initiation of DNA replication ### SEQUENCE -M-A-I-S-P-E-E-I-L-H-I-A-Y-E-E-L-V-E-I-E-P-M-T-S-I-P-E-L-R-L-L-E-R-T-Y-P-P-L-M-P-L-D-I-A-R-I-P-L-Y-A-A-L-L-L-K-K-S-N-M-C-K-I-R-L-P-S-Y-L-Q-L-E-S-L-K-M-S-M-D-V-E-I-E-K-A-D-E-Y-S-C-I-H-P-Y-F-F-P-L-A-T-E-L-L-E-N-C-Y-N-V-E-S-I-E-E-S-K-M-I-V-E-K-I-K-E-I-R-L-A-K-T-L-K-G-I-K-C-L-D-G-K-A-L-N-M-N-N-I-T-L-F-E-F-N-E-I-K-E-L-I-L-G-S-A-E-V-G-R-R-I-E-D-L-A-K-D-Q


### FUNCTION TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation ### SEQUENCE -M-L-K-I-Y-E-D-I-I-N-E-V-I-S-R-L-E-Q-V-E-D-E-V-S-I-G-K-S-A-I-H-E-L-R-N-E-W-R-E-R-L-I-E-Y-T-Q-S-E-W-D-G-E-R-M-R-R-R-D-G-E-Q-G-Y-H-G-Y-E-R-L-S-E-G-P-A-H-A-F-G-G-K-P-T-T-A-K-D-P-G-M-F-E-D-Y-G-S-S-D-V-S-S-G-D-S-E-I-I-G-T-K-G-S-T-G-N-C-M-V-C-L-Y-V-K-V-N-M-S-K-G-K-W-K-C-T-F-K-Q-G-F-I-S-I-G-N-I-D-F-V-F-N-S-A-Q-G-E-L-E-W


### FUNCTION Acts as a sulfur carrier required for 2-thiolation of mcm that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1 The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates ### SEQUENCE -M-K-F-R-F-N-G-A-S-N-V-E-L-N-N-R-E-I-E-L-T-R-E-E-V-E-G-S-S-I-A-T-V-G-D-A-L-R-Y-L-F-G-K-Y-A-E-T-R-D-S-F-F-D-H-H-G-E-L-V-H-G-T-I-C-I-I-N-K-M-D-W-E-I-L-E-K-E-R-S-P-V-K-H-G-D-H-I-V-L-I-S-T-I-H-G-G


### FUNCTION May be involved in mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum EGD2 may also be involved in transcription regulation ### SEQUENCE -M-A-R-A-L-T-T-D-E-S-H-I-H-K-T-L-G-A-K-V-G-L-E-E-V-E-A-V-E-R-I-A-I-V-V-K-D-T-R-Y-S-V-E-S-P-V-A-Y-R-I-K-G-T-D-S-I-L-I-F-G-D-L-G-S-P-V-N-L-H-Q-L-K-R-M-Y-E-D-S-I-R-S-S-K-D-Q-E-G-P-G-L-Y-D-E-I-H-S-D-P-Q-E-D-G-V-K-E-A-E-E-I-T-V-D-P-S-D-E-R-L-S-E-E-D-I-K-L-I-S-S-Q-V-K-A-S-R-N-D-I-I-K-A-L-V-E-S-E-Y-D-V-V-D-A-M-M-K-L-T-K


### FUNCTION Ubiquitin exists either covalently attached to another protein, or free  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked Lys-6-linked may be involved in DNA repair ### SEQUENCE -M-Q-I-F-V-K-T-L-T-G-K-T-I-T-L-E-V-E-P-S-D-S-I-E-N-V-K-A-K-I-Q-D-K-E-G-I-P-P-D-Q-Q-R-L-I-F-A-G-K-Q-L-E-D-G-R-T-L-S-D-Y-N-I-Q-K-E-S-T-L-H-L-V-L-R-L-R-G-G-Y


### FUNCTION Component of the cytosolic iron-sulfur , probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2 ### SEQUENCE -M-E-D-K-E-E-L-R-K-L-L-R-S-M-M-R-K-S-T-D-P-R-T-K-M-Q-D-E-Y-L-T-D-E-D-K-A-I-Q-R-S-E-R-P-P-A-K-K-R-A-C-K-D-C-T-C-G-L-K-E-E-Q-E-V-R-T-R-S-A-C-G-N-C-Y-K-G-D-A-F-R-C-S-G-C-P-S-L-G-L-P-P-Y-E-P-G-D-V-V-S-F-S-M-D-L-S-N-E-F-Q-G-E-D-A


### FUNCTION Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome ### SEQUENCE -M-P-K-S-D-T-K-Q-K-K-R-R-S-N-K-N-R-L-R-I-K-R-A-R-L-F-G-P-K-D-I-D-Q-V-K-E-D-I-E-S-Q-K-K-I-E-Y-D-P-E-L-P-G-G-G-H-F-Y-C-C-E-C-D-R-H-F-I-T-E-K-V-L-M-E-H-K-R-S-N-P-H-R-R-R-A-K-E-V-R-E-V-A-H-S-Q-R-D-A-E-W-A-V-G-L-T


### FUNCTION Promotes the assembly and repair of iron-sulfur clusters by delivering Fe to proteins involved in these pathways ### SEQUENCE -M-L-H-K-Q-T-P-E-D-V-I-T-R-Q-L-Y-H-K-L-A-D-E-T-L-T-D-L-S-E-Q-L-D-K-E-L-D-G-G-Y-A-D-Y-K-D-G-N-L-Q-I-K-I-D-N-V-G-E-Y-M-F-N-K-Q-P-A-S-M-Q-I-W-A-S-S-P-I-T-G-P-R-K-F-D-I-C-R-R-H-E-W-I-D-L-K-S-N-T-S-F-S-R-Y-I-E-E-E-L-R-R-M-R-S-K-M-A-G-K-H-K-K


### FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors ### SEQUENCE -M-E-E-R-E-E-S-I-S-F-V-D-Q-R-F-L-G-S-K-P-L-D-D-T-N-V-L-E-Y-F-S-G-S-P-F-Y-D-K-S-C-N-N-E-I-L-K-M-Q-T-Q-F-R-G-L-D-Q-K-S-K-L-F-S-M-V-G-I-F-Y-E-V-E-S-S-N-H-E-K-T-L-F-V-I-R-K-A-Y-N-H-G-D-T-A-E-T-L-G-M-Y-Y-I-I-H-G-H-V-Y-A-A-P-T-N-Y-S-I-Y-R-C-R-M-G-D-S-M-W-Q-L-N-S-F-I-D-R-M-M-E-K-R-R-F-N-P-F-S-P-P-K-G-R-R-L-A-K-S-L-E-D-S-K-D-L-D-F-M-M-E-I-F-N-D-F-K-K-E-Q-A-E-S


### FUNCTION May be a phenoloxidase inhibitor that stabilizes or inhibits venom phenoloxidase while it is stored in the venom sac ### SEQUENCE -M-S-R-Y-A-L-I-V-L-I-V-V-V-V-A-A-N-L-C-E-A-S-D-C-G-P-N-R-V-Y-K-S-C-G-T-G-C-P-E-T-C-E-N-P-D-P-D-C-D-R-A-C-H-Q-G-C-F-C-S-K-G-L-L-Q-D-I-D-G-N-C-I-S-P-D-K-C-P


### FUNCTION May be a phenoloxidase inhibitor that stabilizes or inhibits venom phenoloxidase while it is stored in the venom sac ### SEQUENCE -M-C-R-Y-A-L-I-V-L-V-V-V-V-V-A-T-N-L-S-E-A-N-I-F-D-V-P-T-C-E-P-N-R-I-Y-K-T-C-G-P-A-C-P-P-T-C-E-D-P-D-P-D-C-N-E-T-P-Q-C-K-A-G-C-F-C-I-P-G-L-I-E-N-M-K-G-G-N-C-I-S-P-S-L-C-P


### FUNCTION Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase ### SEQUENCE -M-L-K-K-F-L-I-S-S-I-V-K-P-T-F-Q-S-R-I-I-A-S-T-T-L-N-G-G-A-G-R-A-T-F-C-S-V-N-S-I-N-P-N-P-T-A-S-Q-I-K-V-D-Q-E-D-L-E-V-G-E-H-L-V-I-D-D-P-N-Q-Q-H-I-K-S-F-L-N-G-V-E-F-N-G-K-S-V-N-I-Y-R-P-S-R-N-T-M-Q-T-G-T-L-R-T-K-K-W-V-I-E-L-P-F-N-P-K-W-N-D-R-L-M-G-W-W-A-S-K-D-T-L-N-Q-L-N-L-R-F-N-S-E-T-D-A-V-A-Y-C-K-E-I-G-L-N-Y-N-I-V-E-E-D-V-T-L-R-K-K-K-K-Y-G-H-R-F-R-Y-R-G-D-L-V-G-E-K-E-R-E-V-G-I-N


### FUNCTION Involved in the mitochondrial division probably by regulating membrane fission Loss-of-function leads to apoptosis ### SEQUENCE -M-T-P-V-E-E-I-I-K-K-D-I-F-R-E-T-P-L-R-Y-L-G-Y-A-N-E-V-G-E-A-F-R-S-L-V-K-P-V-V-V-K-F-S-Y-V-V-A-F-G-Y-V-A-A-D-S-I-D-K-G-L-Q-E-Y-I-K-T-H-S-T-S-T-E-K-T-K-K-V-A-I-A-A-V-D-T-V-L-W-Q-T-F-A-S-V-L-I-P-G-F-T-I-N-R-F-C-F-F-S-N-L-L-L-Q-K-S-T-K-L-P-T-N-M-R-K-W-T-V-T-C-L-G-L-A-T-I-P-F-I-V-H-P-I-D-S-F-V-E-E-A-M-D-K-T-A-R-K-I-Y-N-E-P-T-I-S-N-K-E


### FUNCTION Putative insecticidal toxin ### SEQUENCE -M-A-L-A-L-L-G-L-T-I-K-P-E-H-V-P-E-G-T-G-K-A-V-A-D-V-E-A-L-A-C-D-P-A-Q-C-M-R-S-C-P-F-N-P-F-L-N-Q-Y-G-G-I-C-K-N-G-Q-C-V-C-V-K-P-S


### FUNCTION Depressant insect toxins cause a transient contraction paralysis followed by a slow flaccid paralysis They bind voltage-independently to sodium channels ### SEQUENCE -M-K-L-F-L-L-L-L-I-S-A-S-M-L-I-D-G-L-V-N-A-D-G-Y-I-R-G-S-N-G-C-K-V-S-C-L-W-G-N-E-G-C-N-K-E-C-G-A-Y-G-A-S-Y-G-Y-C-W-T-W-G-L-A-C-W-C-E-G-L-P-D-D-K-T-W-K-S-E-S-N-T-C-G-G-K-K


### FUNCTION Ca with the concomitant emission of light ### SEQUENCE -M-A-S-K-Y-A-V-K-L-Q-T-D-F-D-N-P-K-W-I-K-R-H-K-F-M-F-D-Y-L-D-I-N-G-N-G-Q-I-T-L-D-E-I-V-S-K-A-S-D-D-I-C-K-N-L-G-A-T-P-A-Q-T-Q-R-H-Q-D-C-V-E-A-F-F-R-G-C-G-L-E-Y-G-K-E-T-K-F-P-E-F-L-E-G-W-K-N-L-A-N-A-D-L-A-K-W-A-R-N-E-P-T-L-I-R-E-W-G-D-A-V-F-D-I-F-D-K-D-G-S-G-T-I-T-L-D-E-W-K-A-Y-G-R-I-S-G-I-S-P-S-E-E-D-C-E-K-T-F-Q-H-C-D-L-D-N-S-G-E-L-D-V-D-E-M-T-R-Q-H-L-G-F-W-Y-T-L-D-P-E-A-D-G-L-Y-G-N-G-V-P


### FUNCTION Binds to actin and affects the structure of the cytoskeleton At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations By binding to PIP2, it inhibits the formation of IP3 and DG ### SEQUENCE -M-S-W-Q-Q-Y-V-D-Q-H-L-V-A-T-Q-C-V-T-M-A-A-I-C-G-L-D-G-S-I-W-A-K-S-N-G-L-E-L-S-Q-D-E-V-A-T-L-A-R-S-F-S-K-D-E-V-L-A-A-N-G-I-R-I-G-G-T-K-Y-I-Y-L-S-G-D-D-K-L-I-R-G-K-K-D-R-Q-G-V-H-I-V-K-T-K-T-A-M-V-M-A-L-Y-A-E-P-I-L-P-E-Q-C-A-V-V-V-E-K-L-G-D-W-L-I-Q-N-D-L


### FUNCTION Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions ### SEQUENCE -M-V-H-H-I-T-S-N-D-E-L-Q-K-L-L-S-S-T-T-Y-V-V-V-D-F-F-A-D-W-C-P-P-C-K-A-I-A-P-V-Y-E-Q-L-S-T-K-H-S-V-P-D-V-L-A-F-A-K-V-N-V-D-H-V-Q-D-A-A-Q-Q-Y-G-I-T-A-M-P-T-F-M-F-F-K-E-G-K-Q-V-A-V-N-G-Q-A-V-I-K-G-A-D-P-R-T-L-G-A-A-A-E-K-L-G-G-L-A-Q-K-R-V-A-G-A


### FUNCTION This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA ### SEQUENCE -M-T-L-L-S-S-N-E-L-R-K-L-I-Q-A-T-P-H-L-L-E-N-A-V-D-I-E-T-Q-I-Q-P-N-G-L-E-L-T-L-K-E-I-K-T-I-E-G-V-G-A-V-D-F-D-N-S-E-R-K-V-P-D-A-K-P-L-E-F-E-D-D-D-W-I-H-L-P-K-G-I-Y-K-V-I-F-N-E-I-V-N-I-P-M-N-L-A-A-I-A-K-P-R-S-S-L-I-R-C-G-A-T-L-E-T-A-V-W-D-A-G-Y-R-G-R-S-E-S-M-L-V-V-Y-N-S-A-G-F-R-L-K-K-N-A-R-I-M-Q-L-L-F-Y-T-L-N-S-E-V-E-E-G-Y-S-G-V-Y-Q-N-E-N-T-K


### FUNCTION Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA  and pyrophosphate ### SEQUENCE -M-T-P-L-A-R-F-R-K-V-V-V-G-G-T-F-D-R-L-H-L-G-H-Q-R-L-L-S-V-A-L-E-L-G-D-R-V-V-I-G-V-T-T-D-S-F-V-R-E-E-G-K-K-G-V-E-P-F-E-E-R-V-R-A-V-R-R-F-V-E-E-K-G-A-S-D-R-V-E-I-V-P-L-E-D-R-Y-G-T-T-L-E-D-D-E-M-D-A-I-V-V-S-P-E-T-E-P-V-A-L-E-I-N-E-L-R-R-K-R-G-F-P-P-L-S-I-V-V-I-P-F-V-L-D-G-D-G-R-K-I-S-S-S-R-L-R-G-E-V-D-E-G-P-C-R-D-D


### FUNCTION Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends ### SEQUENCE -M-P-I-T-P-R-N-I-V-R-H-E-L-I-G-L-E-C-R-V-V-K-S-L-G-P-P-Y-E-G-L-E-G-R-I-V-D-E-T-K-N-T-L-V-L-K-T-E-S-G-E-K-V-I-V-K-D-Q-V-L-L-E-L-K-L-P-S-G-E-R-V-R-V-D-G-A-L-L-V-G-R-P-E-E-R-L-S-K-R-I-K-Y-A-E-V-V-R-G-R-F-D-P-E-D-Y-L-D


### FUNCTION Endonuclease that removes tRNA introns Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp ### SEQUENCE -M-L-C-A-G-N-G-G-K-E-L-P-R-A-K-V-F-E-G-G-S-L-V-S-K-D-Y-E-D-L-K-R-R-Y-F-G-T-E-H-G-N-V-L-F-L-D-P-F-E-T-V-Y-L-T-E-K-G-E-I-D-P-E-T-P-E-G-E-P-M-S-V-E-E-L-L-S-F-F-E-R-R-R-P-G-F-R-A-G-Y-V-V-Y-R-D-L-T-E-R-G-Y-V-V-K-S-G-F-K-Y-G-G-R-F-R-V-Y-E-E-D-P-D-R-E-H-S-K-Y-V-V-R-V-V-E-P-D-T-E-L-S-T-R-D-V-L-R-A-T-R-L-A-H-S-V-R-K-D-F-V-L-A-V-V-E-D-V-E-E-P-R-I-E-Y-V-M-W-R-W-K-R-L


### FUNCTION RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus ### SEQUENCE -M-I-R-F-I-L-D-T-S-I-F-V-N-P-D-V-R-K-K-F-G-N-T-P-T-E-A-M-K-T-F-L-K-Y-A-E-K-L-F-G-K-V-E-F-Y-M-P-P-G-I-Y-K-E-V-K-N-F-L-E-D-I-P-P-E-M-E-L-Y-I-I-K-K-P-P-N-V-H-D-I-K-I-P-A-F-V-V-Y-E-L-I-E-D-I-R-R-R-V-D-K-G-L-R-V-A-E-K-A-V-R-E-S-V-I-D-T-N-N-V-D-K-I-I-Q-K-L-R-R-N-Y-R-K-A-L-R-E-G-I-V-D-S-T-E-D-F-E-L-I-L-L-A-K-E-I-D-G-I-I-V-S-A-D-V-G-I-L-T-W-A-E-K-M-G-I-K-W-V-D-A-F-K-F-K-E-L-L-D-E-L-V-E-K-V-E-S-E-K-E-R-K


### FUNCTION Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP May hydrolyze nucleoside diphosphates with lower efficiency ### SEQUENCE -M-K-K-F-R-F-F-V-S-G-M-P-G-V-G-K-T-T-L-A-K-R-I-A-D-E-I-K-R-E-G-F-K-V-G-G-I-I-T-Q-E-I-R-S-G-A-R-R-S-G-F-R-V-I-A-L-D-T-G-E-I-G-R-L-A-Y-V-G-Q-G-Y-P-R-L-G-R-Y-V-I-D-V-E-S-F-E-K-V-A-I-P-A-I-S-R-A-L-R-E-G-D-L-I-V-I-D-E-I-G-P-M-E-F-K-S-N-E-F-L-K-A-L-G-L-V-L-R-S-E-K-P-L-L-A-T-V-H-R-R-F-V-E-R-Y-R-P-L-G-E-Y-Y-W-L-T-P-E-N-R-E-A-V-F-S-E-I-L-V-K-I-K-E-L-L-R-E-N-E-N-A-G-N-K-A-Q-D


### FUNCTION Involved in allosteric regulation of aspartate carbamoyltransferase ### SEQUENCE -M-K-E-K-R-D-L-K-I-Q-A-I-E-N-G-T-V-I-D-H-I-T-A-G-Q-A-L-N-V-L-R-I-L-R-I-S-S-A-F-R-A-T-V-S-F-V-M-N-A-P-G-A-R-G-K-K-D-V-V-K-I-E-G-K-E-L-S-V-E-E-L-N-R-I-A-L-I-S-P-K-A-T-I-N-I-I-R-D-F-E-V-V-Q-K-N-K-V-V-L-P-S-Y-V-E-G-V-V-R-C-M-N-S-N-C-I-S-N-S-S-E-P-I-K-S-K-F-S-V-L-R-T-E-E-E-G-V-S-L-H-C-L-Y-C-E-H-V-I-S-E-E-I-A-E-N-L-L


### FUNCTION General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation ### SEQUENCE -M-S-E-S-S-I-K-I-E-N-V-V-A-S-T-K-L-A-E-E-F-D-L-T-V-I-E-S-E-F-E-G-A-E-Y-N-K-Q-K-F-P-G-L-V-Y-R-V-S-D-P-K-A-A-F-L-V-F-T-S-G-K-V-V-C-T-G-A-K-N-V-A-D-V-H-T-V-I-G-N-M-A-K-K-L-N-S-I-G-I-K-T-M-E-N-P-Q-I-T-V-Q-N-I-V-A-S-A-D-L-H-T-I-L-N-L-N-A-I-A-I-G-L-G-L-E-N-I-E-Y-E-P-E-Q-F-P-G-L-V-Y-R-I-D-E-P-K-V-V-V-L-I-F-S-S-G-K-L-V-V-T-G-G-K-S-P-E-D-C-E-R-G-V-E-V-V-R-Q-Q-L-D-N-M-G-L-L


### FUNCTION Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors ### SEQUENCE -M-T-S-I-V-E-A-L-V-P-G-G-K-A-N-P-G-P-P-L-G-P-A-L-G-P-L-G-V-N-I-K-E-V-V-E-K-I-N-E-K-T-R-D-Y-N-G-M-Q-V-P-V-K-V-I-V-D-D-K-K-N-V-E-I-E-V-G-T-P-P-T-A-S-L-V-M-K-E-L-G-I-Q-K-G-S-G-N-A-G-S-E-V-V-G-N-L-T-I-S-Q-V-A-K-V-A-R-M-K-K-E-D-V-L-S-Y-D-L-K-A-A-M-K-E-V-M-G-S-C-V-P-M-G-V-N-V-E-G-M-K-A-K-D-C-Q-K-A-L-D-E-G-K-F-D-D-L-L-A-G-E-A-W


### FUNCTION Essential subunit of the Sec protein translocation channel SecYEG Clamps together the 2 halves of SecY May contact the channel plug during translocation ### SEQUENCE -M-V-E-S-T-F-E-P-N-I-T-T-K-S-V-G-Q-A-I-R-A-H-L-R-V-L-K-L-T-K-K-P-S-R-E-E-F-L-T-I-A-K-V-A-G-A-G-I-L-A-V-G-A-I-G-F-I-I-Y-V-L-L-T-M-L-P-Q-W-V-S-Q


### FUNCTION Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7 ### SEQUENCE -M-S-E-I-V-S-V-S-G-G-P-T-K-P-E-I-I-A-V-S-L-S-K-L-G-L-Q-D-G-D-R-F-A-D-V-G-C-G-T-G-S-V-S-I-E-A-A-R-I-A-R-N-L-T-I-Y-A-I-D-A-R-K-E-A-L-L-A-T-E-A-N-F-K-S-F-G-I-E-N-A-R-V-L-A-G-E-A-S-E-L-L-G-S-G-G-S-I-D-S-I-D-C-A-F-V-G-G-T-K-N-I-D-A-I-L-E-K-L-V-E-K-K-T-R-S-I-V-V-N-A-V-R-I-E-T-V-V-R-T-I-E-A-M-K-K-L-G-I-F-D-E-V-V-H-I-S-V-S-R-S-A-P-I-A-G-E-T-M-F-K-P-E-N-P-V-Y-I-V-V-G-K-K-Q-A


### FUNCTION Produces ATP from ADP in the presence of a proton gradient across the membrane ### SEQUENCE -M-E-L-A-V-I-G-K-S-E-F-V-T-G-F-R-L-A-G-I-R-K-V-Y-E-I-V-D-V-P-S-S-E-S-A-V-K-S-V-L-E-D-K-S-I-G-I-L-V-M-H-N-D-D-I-S-N-L-P-E-I-L-R-R-N-L-N-E-S-V-Q-P-T-V-V-A-L-G-G-T-G-E-G-S-M-S-L-R-D-K-I-K-Q-A-V-G-V-D-L-W-K


### FUNCTION Produces ATP from ADP in the presence of a proton gradient across the membrane ### SEQUENCE -M-G-L-E-I-V-I-K-D-I-Q-E-G-A-R-A-E-V-S-R-I-N-T-E-A-D-A-K-A-S-E-I-T-N-E-A-K-E-V-Q-K-K-M-L-G-D-S-L-A-K-V-E-E-D-L-Q-K-L-H-Q-Q-V-I-S-S-A-N-L-E-V-K-R-I-T-L-N-K-R-K-E-L-L-D-N-V-Y-S-Q-T-V-E-S-I-K-S-M-P-A-S-K-N-E-K-L-L-K-H-I-I-D-K-Y-E-A-S-G-D-K-I-Y-S-S-K-A-S-E-E-T-V-R-K-L-S-S-L-T-Y-A-G-N-I-D-C-I-G-G-V-V-L-E-N-E-D-G-T-V-R-L-D-Y-T-Y-D-S-I-L-K-N-V-Y-E-R-S-L-K-Q-I-S-D-I-L-Y-G


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-A-E-V-S-E-E-I-R-N-L-A-A-R-H-Q-E-L-Q-R-Q-A-E-A-L-R-Q-E-M-G-M-I-Q-T-S-I-S-S-C-D-Q-T-I-V-T-I-N-E-L-K-A-A-S-E-A-G-K-P-A-E-T-M-V-P-V-G-F-G-S-Y-V-Y-A-E-V-K-N-P-D-R-I-I-V-N-L-G-A-E-F-S-A-E-E-T-A-E-E-A-I-E-T-L-N-R-R-K-E-Q-L-T-K-I-L-E-Q-M-N-A-S-L-T-R-L-T-Q-G-M-Q-T-L-E-A-E-A-A-K-L-Q-P-G-Q-A


### FUNCTION Fluoride-specific ion channel Important for reducing fluoride concentration in the cell, thus reducing its toxicity ### SEQUENCE -M-I-G-T-G-G-F-I-G-A-S-L-R-Y-T-I-S-S-R-V-P-K-I-Q-N-I-P-A-G-T-L-T-V-N-L-L-G-S-I-V-L-A-L-L-T-F-S-S-E-P-E-S-V-V-Y-L-V-N-I-G-M-L-G-S-F-T-T-F-S-T-F-A-Y-E-T-F-R-L-L-E-D-G-Q-N-I-S-F-F-L-N-I-F-L-N-V-M-L-C-L-L-G-V-S-I-A-Y-L-A-L-M-L


### FUNCTION Fluoride-specific ion channel Important for reducing fluoride concentration in the cell, thus reducing its toxicity ### SEQUENCE -M-P-S-Q-D-K-E-I-D-K-I-F-L-I-G-A-G-G-F-L-G-A-V-C-R-F-L-L-C-E-L-V-E-G-Q-L-G-I-L-S-V-N-V-I-G-S-F-M-L-G-M-I-M-Y-D-T-E-Y-L-G-F-I-G-P-K-G-K-I-A-F-G-T-G-F-M-G-A-F-T-T-F-S-T-F-A-V-Q-S-F-S-L-P-F-I-P-A-L-G-N-I-S-A-N-I-F-L-T-L-T-G-V-F-F-G-R-S-V-I-K-A-L-S-S-R-E-I


### FUNCTION Transcriptional regulator ### SEQUENCE -M-E-T-E-L-M-R-I-G-V-S-L-P-D-T-L-L-S-K-F-D-E-I-I-E-K-R-G-Y-S-S-R-S-E-G-I-R-D-A-I-R-S-Y-I-S-Y-Y-E-W-M-G-D-I-K-G-H-R-V-G-T-V-A-V-I-Y-D-H-T-K-R-G-L-S-N-A-L-A-D-I-Q-H-H-Y-S-H-L-I-K-S-S-V-H-I-H-L-D-H-D-N-C-F-E-V-I-V-L-D-G-D-G-E-E-I-K-E-L-A-E-A-I-M-A-L-K-G-V-K-F-S-K-L-T-T-V-A-S-N-E-K-I


### FUNCTION Fluoride-specific ion channel Important for reducing fluoride concentration in the cell, thus reducing its toxicity ### SEQUENCE -M-Y-T-I-L-L-I-G-I-G-G-F-I-G-A-V-L-R-Y-S-L-S-G-W-V-Q-N-S-F-V-N-F-P-L-G-T-L-V-V-N-I-V-G-S-F-F-L-G-L-V-M-Y-L-S-E-Y-Q-G-L-F-S-E-E-T-R-I-L-L-T-I-G-L-L-G-A-F-T-T-L-S-T-F-S-Y-E-S-F-R-L-L-E-S-S-K-L-M-Q-L-T-M-N-I-V-A-T-V-L-F-S-I-F-A-V-Y-L-G-K-I-S-A-L-N-L-A-A-Y-L-R-G-I-K


### FUNCTION Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein  and RNA polymerase recruitment Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes ### SEQUENCE -M-N-T-L-V-D-L-N-D-K-V-I-R-G-Y-L-I-S-L-V-G-E-E-G-L-R-M-I-E-E-M-P-E-G-E-V-T-D-E-E-I-A-A-K-T-G-V-L-L-N-T-V-R-R-T-L-F-I-L-Y-E-N-K-F-A-I-C-R-R-E-R-D-S-N-S-G-W-L-T-Y-L-W-H-L-D-F-S-D-V-E-H-Q-L-M-R-E-K-K-K-L-L-R-N-L-K-T-R-L-E-F-E-E-N-N-V-F-Y-V-C-P-Q-G-C-V-R-L-L-F-D-E-A-T-E-T-E-F-L-C-P-M-C-G-E-D-L-V-Y-Y-D-N-S-R-F-V-S-A-L-K-K-R-V-D-A-L-S-S-V


### FUNCTION Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase The precise role of the epsilon subunit is unclear ### SEQUENCE -M-V-D-T-T-K-N-T-K-L-F-T-S-Y-G-V-T-T-S-K-T-T-T-P-E-I-A-A-K-L-I-S-K-A-K-R-P-L-L-V-V-G-T-K-V-L-D-P-E-L-L-D-R-A-V-K-I-A-Q-K-A-N-I-P-I-A-A-T-G-S-S-M-P-G-F-V-G-K-D-V-D-A-K-Y-I-N-L-H-Q-L-G-F-Y-V-T-D-P-N-W-P-G-L-D-G-N-G-T-Y-D-T-L-I-V-L-G-H-I-K-Y-Y-I-N-Q-V-L-S-G-T-K-N-F-S-T-V-K-A-I-A-I-E-R-N-Y-I-Q-N-A-T-M-S-F-G-N-L-S-K-A-D-H-Y-A-A-L-D-E-L-I-D-A-L


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-T-S-E-L-P-P-Q-I-Q-N-Q-I-A-Q-L-Q-Q-V-Q-Q-Q-V-Q-A-L-A-M-Q-K-S-Q-I-E-A-M-Q-K-E-S-K-M-A-L-E-E-L-E-K-L-A-D-D-A-V-V-Y-R-N-V-G-E-L-V-I-K-T-S-K-E-E-S-V-S-K-L-K-D-R-E-E-T-L-S-L-R-L-Q-S-I-S-R-Q-E-E-R-L-T-T-R-F-K-Q-L-Q-E-Q-I-Q-Q-A-L-G-P-K-A-Q


### FUNCTION Probably functions as a manganese efflux pump ### SEQUENCE -M-S-F-L-T-N-F-L-L-G-L-G-L-A-M-D-A-F-A-V-S-M-S-S-G-T-T-I-R-P-F-R-V-S-D-A-L-K-L-A-V-F-F-G-S-F-Q-A-M-M-P-V-L-G-W-I-G-G-S-T-V-S-S-F-V-S-D-Y-A-P-W-I-A-F-L-L-L-A-F-I-G-C-K-M-I-Y-E-A-L-Y-G-D-Q-D-G-K-V-N-S-L-N-Y-S-V-L-F-L-L-A-V-A-T-S-I-D-A-L-A-V-G-M-S-F-A-F-L-G-T-P-I-L-E-P-V-I-I-I-G-C-V-T-F-V-M-S-F-C-G-A-I-L-G-Y-R-L-G-H-F-F-E-H-E-V-E-I-L-G-G-L-I-L-I-G-L-G-G-K-I-L-A-E-H-M-L-W-I


### FUNCTION Broad-specificity nucleoside monophosphate  kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates ### SEQUENCE -M-L-I-G-L-T-G-T-P-G-T-G-K-T-S-V-S-K-L-L-E-K-K-R-Q-W-K-I-I-H-L-N-E-L-I-K-E-E-H-L-Y-T-E-V-D-E-K-R-D-S-V-V-A-D-M-E-L-V-R-S-R-L-P-E-L-I-N-E-M-E-K-E-P-A-N-K-V-V-I-L-E-S-H-L-A-H-Y-I-T-D-I-V-I-V-L-R-A-Y-P-P-E-L-K-K-R-L-E-K-R-G-Y-S-E-E-K-V-N-E-N-A-E-A-E-S-I-D-L-I-L-A-E-A-F-E-W-C-D-K-V-F-E-I-N-T-T-G-R-T-A-E-E-T-A-G-D-V-E-K-I-I-D-S-L-L-S-G-K-E-E-Q-L-Q-E-Y-G-P-G-S-L-D-W-I-D-S-V-P


### FUNCTION Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A ### SEQUENCE -M-S-V-H-I-E-L-P-T-E-L-R-P-L-M-K-R-P-L-G-T-L-Y-R-G-K-G-R-D-T-V-E-K-F-V-G-E-L-A-S-P-T-K-L-I-S-V-G-D-V-T-T-F-H-L-L-E-A-G-I-I-P-D-I-C-I-V-D-N-R-T-K-R-K-P-V-S-R-D-V-S-D-R-N-R-D-K-V-Y-E-E-V-S-V-D-N-P-A-G-I-I-T-D-E-L-I-K-T-L-C-E-A-F-D-S-E-K-L-L-R-I-F-V-R-G-E-E-D-L-A-T-L-P-V-I-L-M-A-P-L-G-S-V-V-L-Y-G-Q-P-D-E-G-V-V-F-V-R-V-T-E-E-K-K-E-E-I-R-V-L-F-E-K-L-I-S-K-N-Q-N-T-E-L-D-K-I-R-R-I-L-D-G-H-K-D-P


### FUNCTION CRISPR  Functions as a ssRNA-specific endoribonuclease Involved in the integration of spacer DNA into the CRISPR cassette ### SEQUENCE -M-Y-V-V-I-V-Y-D-V-G-V-E-R-V-N-K-V-R-S-F-L-R-E-Y-M-N-W-V-Q-N-S-V-F-E-G-E-L-T-K-A-E-F-L-K-I-K-S-R-L-K-E-L-I-Q-E-S-S-D-H-I-I-F-Y-S-S-R-D-R-K-Y-L-G-I-E-D-L-G-T-P-K-A-D-T-S-N-I-I


### FUNCTION Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP May hydrolyze nucleoside diphosphates with lower efficiency ### SEQUENCE -M-L-R-I-A-V-T-G-S-P-G-V-G-K-S-T-V-V-A-K-T-A-E-K-L-A-E-K-P-G-F-K-I-G-G-I-R-T-A-E-I-R-K-E-G-H-R-E-G-F-S-I-R-D-L-A-T-G-K-T-G-I-L-S-H-V-K-G-S-G-P-R-L-G-K-Y-H-V-N-L-D-D-L-E-R-I-G-A-N-A-V-R-N-A-L-A-C-D-L-V-V-I-D-E-I-G-P-M-E-L-I-S-Q-S-F-V-S-A-V-E-E-V-L-E-S-D-K-P-V-L-A-V-L-H-H-S-S-R-H-P-L-A-Q-R-F-R-K-G-F-E-V-L-T-V-D-K-G-N-R-D-E-L-P-E-K-I-T-N-R-F-L-R-K-L-G


### FUNCTION Catalyzes the formation of CDP-2,3-bis- and CTP This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids ### SEQUENCE -M-L-P-A-Y-L-S-N-P-F-A-A-V-F-G-G-G-K-P-I-D-G-G-R-T-Y-K-D-G-R-R-I-L-G-D-G-K-T-Y-R-G-L-F-S-G-I-F-C-G-F-L-A-G-C-I-E-I-W-L-S-M-R-G-F-E-I-M-G-I-K-M-P-T-F-G-P-N-Y-A-S-A-L-I-V-V-L-A-L-P-S-G-A-L-F-G-D-M-F-K-S-F-F-K-R-R-M-G-L-K-R-G-A-S-L-P-L-V-D-Q-L-D-F-V-V-G-A-W-F-F-T-Y-L-A-A-P-E-W-F-V-S-N-F-T-T-G-I-A-L-T-V-L-I-M-T-P-L-L-H-L-T-T-N-I-I-G-Y-F-I-G-V-K-K-E-P-W


### FUNCTION The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis ### SEQUENCE -M-S-E-Y-K-Q-C-I-V-T-R-D-D-L-K-L-S-K-G-K-F-A-V-Q-V-A-H-A-A-L-S-A-A-E-W-A-S-K-S-D-L-E-K-W-K-E-G-G-Q-K-K-I-V-L-R-V-P-T-I-K-D-L-Y-E-L-K-E-K-A-R-R-E-G-L-P-T-A-L-I-Q-D-A-G-L-T-E-I-P-A-G-T-V-T-V-L-G-I-G-P-A-K-E-E-V-I-D-K-V-T-R-D-L-K-L-V


### FUNCTION Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs ### SEQUENCE -M-K-R-I-V-L-L-R-L-G-H-R-P-E-R-D-K-R-I-T-T-H-V-G-L-T-A-R-M-L-G-A-E-G-M-L-L-A-S-D-D-Q-G-I-V-H-S-L-E-D-V-V-R-R-W-G-G-D-F-Y-I-K-N-N-V-N-F-K-Q-E-I-R-A-W-K-E-E-G-G-K-V-C-H-L-S-M-Y-G-V-N-L-P-D-V-T-G-E-L-K-K-C-K-K-L-M-I-V-V-G-A-E-K-V-P-P-E-I-Y-Q-L-A-N-W-N-V-A-V-G-S-Q-P-H-S-E-V-A-A-V-A-I-T-M-D-R-I-A-E-G-E-P-L-E-K-E-F-P-G-A-E-L-T-I-V-P-A-E-R-G-K-H-V-I-E-N-I-R-E


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-S-K-G-T-S-S-M-G-K-R-Q-K-R-T-H-A-K-C-R-R-C-G-S-V-S-F-N-V-H-T-K-Q-C-T-S-C-G-F-G-K-T-S-R-M-R-T-Y-K-W-Q-A-K-C-K-Y


### FUNCTION Transcriptional regulator ### SEQUENCE -M-E-K-K-L-M-R-I-G-V-S-L-P-G-E-L-L-D-K-F-D-K-T-L-M-K-R-G-Y-S-S-R-S-E-G-I-R-D-A-I-R-T-Y-N-Q-H-Y-E-W-M-Q-Q-I-K-G-A-R-A-A-T-I-S-L-V-Y-D-C-S-K-K-G-I-T-S-T-L-A-K-I-Q-H-E-Y-I-D-L-I-T-S-S-V-H-F-H-I-E-E-D-F-C-F-E-T-I-I-L-E-G-E-G-E-K-I-V-E-L-A-E-K-I-L-S-L-K-G-V-K-H-S-R-L-T-T-M-P-E-V-K-T-E


### FUNCTION Catalyzes the hydrolysis of inorganic pyrophosphate  forming two phosphate ions ### SEQUENCE -M-L-D-M-T-E-R-Q-V-E-S-V-L-I-E-I-P-K-G-S-R-N-K-Y-E-Y-D-K-E-K-K-V-I-K-F-D-R-M-L-F-S-S-M-V-Y-P-C-D-Y-G-F-F-P-D-T-L-A-L-D-G-D-P-L-D-A-L-V-L-T-W-E-P-T-F-P-G-C-V-I-D-V-H-P-V-A-L-L-D-M-K-D-D-K-G-R-D-E-K-I-L-C-V-P-E-T-D-P-L-W-N-Y-I-E-T-L-E-Q-V-P-P-H-L-L-K-E-I-V-H-F-F-E-T-Y-K-N-L-E-G-K-H-V-I-V-I-G-W-E-G-L-D-A-A-V-D-M-L-R-E-A-K-S-R-Y-L-E-K-N-K


### FUNCTION Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in Mjannaschii 16S rRNA It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3- ### SEQUENCE -M-M-N-P-T-N-S-R-D-V-P-L-Y-I-Y-H-A-G-Q-C-D-P-K-K-C-T-G-R-K-M-A-R-F-E-L-A-R-L-Y-D-K-I-S-R-L-P-R-S-A-I-L-L-D-P-M-A-E-K-A-L-S-P-A-D-D-P-K-K-G-I-I-V-L-D-C-S-W-E-E-V-E-R-V-F-P-E-L-E-K-L-N-L-E-H-R-A-L-P-Y-M-L-A-G-N-P-V-N-F-G-R-P-F-K-L-N-S-A-E-A-F-A-A-A-L-Y-I-L-G-Y-K-E-Q-A-E-K-V-M-S-K-F-N-W-G-H-S-F-L-E-L-N-R-E-P-L-D-E-Y-A-T-A-K-N-S-S-E-I-V-E-I-Q-S-H-Y-I


### FUNCTION Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-uracil with 3,4-dihydroxy-2-butanone 4-phosphate This is the penultimate step in the biosynthesis of riboflavin ### SEQUENCE -M-T-I-S-L-G-F-V-I-A-E-F-N-R-D-L-T-Y-Q-M-E-L-L-G-R-E-H-A-E-F-L-G-A-T-V-K-E-T-I-L-V-P-G-V-F-D-M-P-L-A-I-K-K-L-C-Q-R-E-D-I-D-A-V-V-T-I-G-S-V-I-E-G-E-T-D-H-D-Q-V-V-M-Q-H-A-A-R-K-I-M-D-L-S-L-E-F-N-K-P-V-T-L-G-I-P-G-P-G-M-T-R-M-A-A-H-E-R-V-D-Y-A-K-R-A-V-E-A-A-V-K-L-V-R-R-L


### FUNCTION Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends ### SEQUENCE -M-K-R-L-L-P-S-L-R-T-K-K-R-Y-L-A-F-E-L-I-S-E-E-P-A-G-R-G-D-I-V-K-E-V-I-S-S-A-S-S-L-L-G-D-I-T-T-S-D-C-D-I-R-V-L-G-F-E-A-G-K-G-I-I-Q-C-S-H-T-R-V-K-E-T-R-A-A-L-A-T-L-T-R-V-N-G-K-R-A-T-L-H-V-L-G-A-S-G-T-V-K-K-A-T-E-K-F-L-K-D-Y-T-V-F-E-P-E-I-H-E-K-R-D-S-R-K-T-P-G-K-V-D


### FUNCTION Ferredoxin that is the specific electron donor for the geranylgeranyl reductase GGR involved in the biosynthesis of archaeal membrane lipids ### SEQUENCE -M-V-W-H-Y-T-N-D-V-A-L-Y-C-R-A-F-R-S-M-P-H-C-L-R-E-R-Q-Y-F-M-V-K-D-H-D-L-L-L-K-L-T-G-E-L-V-S-V-N-I-N-R-Y-K-C-G-Y-C-G-A-C-V-G-V-C-P-K-G-A-L-E-L-V-E-T-W-I-E-V-D-E-S-T-C-I-K-C-G-I-C-D-R-I-C-P-V-G-A-I-E-V-M-K


### FUNCTION Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA ### SEQUENCE -M-G-D-V-A-A-K-I-K-I-M-P-E-S-I-E-T-D-L-A-E-L-K-E-K-I-K-A-V-I-P-A-K-A-D-L-H-G-D-I-V-E-E-P-I-A-F-G-L-K-A-L-I-V-T-L-I-V-N-D-E-E-G-G-T-E-P-A-E-E-A-F-A-K-V-S-G-V-E-N-V-Q-V-L-E-A-Y-R-I


### FUNCTION Transcriptional regulator ### SEQUENCE -M-E-T-E-L-M-R-I-G-I-S-L-P-D-I-L-L-G-E-F-D-E-I-I-G-K-R-G-Y-S-S-R-S-E-G-I-R-D-A-I-R-S-Y-I-S-Y-Y-E-W-M-N-D-I-K-G-H-R-V-G-T-I-A-F-V-Y-D-H-T-K-R-G-L-S-N-S-L-T-D-I-Q-H-H-Y-S-H-L-I-K-S-S-I-H-V-H-L-D-H-K-E-C-F-E-V-V-V-L-N-G-D-G-K-E-I-A-E-L-S-E-T-M-M-V-L-K-G-V-K-F-S-K-L-T-T-V-A-S-N-E-N-I


### FUNCTION Seems to be required for maximal rate of protein biosynthesis Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA ### SEQUENCE -M-I-R-K-R-Q-S-G-S-N-K-S-V-S-S-G-N-N-Q-E-V-T-R-V-R-T-P-R-K-D-R-N-E-V-L-A-T-V-A-S-L-L-G-S-K-R-V-T-L-Q-C-M-D-G-V-V-R-M-G-R-I-P-G-S-K-N-K-K-M-W-V-R-E-G-D-V-V-I-A-N-P-W-E-I-Q-D-S-K-A-D-V-I-W-K-Y-T-K-P-Q-V-D-W-L-E-R-K-G-Y-L-N


### FUNCTION Seems to be required for maximal rate of protein biosynthesis Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA ### SEQUENCE -M-R-K-R-R-E-G-S-A-A-P-S-T-Q-E-V-T-R-V-R-T-P-R-K-E-N-H-E-V-L-A-T-V-G-S-L-L-G-S-K-R-V-N-L-Q-C-M-D-G-V-V-R-M-G-R-I-P-G-S-K-N-K-K-M-W-I-R-E-G-D-V-V-I-V-T-P-W-E-I-Q-D-T-K-A-D-V-I-W-K-Y-T-R-P-Q-I-E-W-L-E-R-K-G-Y-L-K


### FUNCTION Probable toxic component of a putative type VII toxin-antitoxin  system, probably an RNase Probably neutralized by cognate antitoxin MA_1295 Neutralization may be due to AMPylation by MA_1295 ### SEQUENCE -M-K-K-D-D-R-V-Y-L-N-H-I-L-Q-S-V-S-L-I-E-K-Y-T-E-D-L-T-E-E-E-F-L-S-N-S-L-F-Q-D-A-T-I-R-Q-I-Q-I-I-G-E-A-T-K-N-L-S-K-S-L-R-D-K-Y-P-Q-V-H-W-R-G-I-A-G-M-R-D-K-L-I-H-D-Y-F-G-V-D-I-N-A-V-W-D-T-I-K-E-D-I-P-A-L-K-K-I-V-L-E-I-I-Q-D-L-N-G-N-P


### FUNCTION With S4 and S5 plays an important role in translational accuracy Located at the interface of the 30S and 50S subunits ### SEQUENCE -M-A-K-G-K-Y-A-A-N-I-L-K-Q-T-R-K-D-A-R-W-K-D-T-Y-Y-G-R-R-V-L-G-L-N-V-K-A-D-P-L-G-G-A-P-Q-G-R-G-I-V-L-E-K-V-G-V-E-A-K-Q-P-N-S-A-I-R-K-C-V-R-V-Q-L-I-K-N-G-R-Q-V-T-A-F-C-P-G-D-G-A-V-N-F-I-D-E-H-D-E-V-T-V-E-K-I-G-G-R-M-G-G-A-M-G-D-I-P-G-V-R-F-K-V-I-A-V-N-N-V-S-L-N-Q-L-V-I-G-R-M-E-K-P-R-R


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit Is located at the subunit interface close to the decoding center ### SEQUENCE -M-I-F-L-Y-K-I-F-G-K-W-D-P-T-E-V-E-V-K-D-L-G-I-K-R-Y-V-S-L-T-P-V-I-V-P-H-S-S-G-K-H-A-R-Q-Q-F-N-K-S-E-I-S-I-V-E-R-L-A-N-N-L-M-R-T-E-T-N-T-G-K-K-Q-V-T-L-R-A-V-E-E-A-F-D-I-V-N-K-K-T-K-Q-N-P-I-Q-V-L-V-D-A-I-A-N-A-G-P-R-E-E-V-V-R-L-K-Y-G-G-I-S-V-P-K-A-V-D-T-A-P-Q-R-R-V-D-T-A-L-R-Y-I-S-M-G-T-N-A-A-A-F-K-S-K-R-S-V-A-E-C-L-A-T-E-L-I-G-A-A-N-R-D-T-K-S-F-S-I-N-R-K-D-A-K-E-R-V-A-K-A-A-R


### FUNCTION Catalyzes the conversion of ### SEQUENCE -M-I-F-V-E-K-S-F-T-H-I-E-A-D-R-A-R-M-V-D-I-S-E-K-N-N-V-L-R-M-A-R-A-A-G-E-I-V-L-S-A-E-T-M-E-K-I-R-T-G-T-V-E-K-G-N-V-F-A-T-A-R-V-A-A-V-L-A-V-K-K-T-P-E-T-I-P-M-C-H-Q-I-P-I-T-G-I-D-V-D-L-E-I-G-K-D-S-V-S-A-V-V-E-V-R-T-V-G-K-T-G-V-E-M-E-A-L-T-G-V-S-V-A-L-L-T-V-W-D-M-V-K-S-A-E-K-D-E-T-G-N-Y-P-H-T-L-I-R-N-I-R-V-L-E-K-L-K-G


### FUNCTION Involved in the maturation of  hydrogenases Required for nickel insertion into the metal center of the hydrogenase ### SEQUENCE -M-H-E-Y-S-I-A-C-E-I-F-E-Q-V-I-E-T-A-K-V-H-G-A-L-E-V-R-H-V-T-L-E-M-G-R-L-S-H-T-N-P-E-Q-L-S-F-C-F-K-A-I-A-E-G-S-I-A-E-N-A-E-F-I-V-E-T-I-P-P-S-L-E-C-E-C-G-Y-T-G-T-V-D-E-T-Q-I-G-K-N-D-E-L-Q-S-E-L-L-E-Y-I-A-A-L-E-C-P-V-C-G-K-N-A-R-I-I-G-G-R-E-L-I-V-K-S-I-E-I-E-T-E-V-E-Q


### FUNCTION Located on the platform of the 30S subunit ### SEQUENCE -M-A-D-M-K-W-A-V-A-H-I-K-S-S-F-N-N-T-I-I-T-V-T-D-I-T-G-A-E-T-I-A-K-S-S-G-G-M-V-V-K-A-A-R-D-E-S-S-P-Y-T-A-M-Q-M-A-G-Q-L-A-D-Q-L-K-D-K-G-I-N-G-I-H-I-R-V-R-A-P-G-G-N-K-Q-R-S-P-G-P-G-A-Q-A-A-I-R-A-F-A-R-A-G-I-R-I-G-R-I-E-D-V-T-P-V-P-H-D-G-T-R-P-K-G-G-R-R-V


### FUNCTION Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA In the 70S ribosome it contacts the 23S rRNA , connecting the 2 subunits ### SEQUENCE -M-L-Y-A-L-Q-W-R-K-Y-M-V-E-E-N-N-N-E-E-L-R-H-L-V-R-I-M-N-T-D-L-Q-G-A-K-P-V-Q-Y-A-L-T-G-L-P-G-V-G-R-R-T-A-K-L-I-A-K-G-A-G-V-D-P-S-A-I-L-G-Y-L-P-E-E-E-V-A-K-L-D-T-A-I-G-K-F-E-D-I-V-P-S-W-M-L-N-R-Q-K-D-L-A-T-G-Q-D-K-H-L-L-G-T-D-I-L-L-T-F-R-E-D-I-N-N-L-K-K-V-R-A-Y-R-G-L-R-H-E-R-G-L-K-V-R-G-Q-R-T-K-S-T-G-R-R-G-S-T-V-G-V-S-R-K-K


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-D-T-K-K-F-R-G-S-R-T-C-G-G-G-T-H-K-N-R-R-G-A-G-N-R-G-G-R-G-K-A-G-G-C-K-H-H-F-V-R-A-M-M-R-G-Y-S-Y-G-K-H-G-F-K-R-P-D-E-V-S-R-D-V-S-I-V-N-V-G-E-L-D-E-L-A-S-Y-L-V-E-E-G-L-A-E-V-K-D-G-A-Y-H-I-N-L-E-N-L-G-I-E-K-V-L-G-S-G-R-V-T-K-N-L-V-V-T-S-E-E-F-S-A-S-A-R-E-K-I-E-N-A-G-G-S-C-I-D-A-E


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-A-T-G-P-R-Y-K-V-P-F-R-R-R-R-E-G-R-T-N-Y-H-L-R-L-K-L-L-L-S-R-Q-D-R-V-V-V-R-K-S-S-R-N-V-Q-I-Q-L-I-A-P-T-P-D-G-D-I-T-Y-S-S-A-V-S-N-E-L-A-K-Y-G-Y-T-G-A-T-G-N-T-T-A-A-Y-L-T-G-L-L-F-G-L-K-S-L-Q-K-G-Y-E-G-G-I-L-D-I-G-L-Q-A-S-S-A-G-S-R-V-Y-A-A-L-K-G-V-V-D-S-G-F-E-I-P-C-S-P-E-V-F-P-P-D-E-R-I-R-G-E-H-I-A-G-Y-R-E-E-S-S-D-L-P-E-Q-F-E-A-T-K-E-K-I-F-A-E-F-S


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-V-K-E-I-A-R-T-I-E-I-P-E-G-V-S-V-S-L-A-Q-D-V-F-T-A-T-G-P-K-G-T-V-E-R-K-L-W-Y-P-G-I-M-I-D-V-K-D-G-E-V-V-V-D-A-E-Y-A-R-K-E-Q-K-A-M-V-G-T-F-A-S-H-I-R-N-L-V-K-G-V-N-E-G-F-E-C-K-M-S-I-V-Y-A-H-F-P-M-Q-V-K-V-D-G-K-T-L-I-I-G-N-F-L-G-E-K-K-P-R-F-A-K-I-I-G-E-T-K-V-K-V-S-G-N-D-V-T-I-T-G-I-N-K-E-D-V-G-Q-T-A-A-N-I-E-Q-K-T-K-I-K-R-F-D-P-R-I-F-Q-D-G-I-Y-I-V-Q-K-A


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-V-L-L-D-P-L-A-N-A-L-S-T-I-K-N-A-E-A-I-G-K-S-S-C-V-V-R-P-A-S-K-N-I-G-N-V-L-K-V-M-Q-D-L-G-Y-I-G-D-F-E-F-I-D-D-G-K-A-G-I-Y-S-V-T-L-V-G-R-I-N-K-C-G-A-I-K-P-R-Y-S-V-G-T-A-S-F-E-R-W-E-K-Q-F-L-P-A-K-N-F-G-A-L-I-V-T-T-S-S-G-V-M-S-Q-Y-E-A-R-D-K-K-I-G-G-Q-L-L-A-Y-V-Y


### FUNCTION Binds 16S rRNA, required for the assembly of 30S particles ### SEQUENCE -M-T-E-T-I-K-K-S-G-R-G-V-N-E-C-K-R-C-G-R-K-Q-G-L-V-R-K-Y-D-I-Y-L-C-R-H-C-F-R-E-I-A-H-E-M-G-F-E-K-Y-S


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-R-T-P-I-V-E-K-V-I-V-H-M-G-V-G-E-S-G-Q-H-L-V-N-A-E-D-I-L-R-N-I-T-G-Q-E-V-V-R-C-F-A-K-R-T-L-P-A-F-S-I-K-K-N-E-P-I-G-C-K-V-T-L-R-G-Q-K-A-Q-E-F-L-E-T-A-L-G-I-V-E-K-T-L-N-R-S-Q-F-D-S-F-G-N-V-S-F-G-I-E-E-H-T-D-F-P-G-M-R-Y-D-P-N-I-G-V-F-G-M-D-V-T-V-V-L-K-R-P-G-E-R-I-C-K-R-R-I-A-A-R-K-I-P-A-G-H-R-V-T-V-D-D-A-I-A-F-L-N-E-S-Y-G-V-E-V-M


### FUNCTION One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit ### SEQUENCE -M-I-A-M-V-S-K-Q-P-R-K-Q-R-K-A-R-Y-A-A-P-L-H-I-R-Q-K-F-M-G-A-R-L-S-E-A-L-T-K-E-Y-G-T-R-S-A-A-V-I-T-G-D-T-V-K-V-M-R-G-D-F-K-G-T-E-G-K-V-Q-S-V-S-L-M-D-G-T-I-T-V-D-G-V-I-S-T-K-V-D-G-T-E-V-P-R-P-L-N-P-S-N-V-M-I-T-K-L-E-M-K-D-G-R-R-A-S-S-I-K-K


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-K-G-M-R-S-N-I-P-R-A-L-N-A-G-A-Q-I-A-C-V-D-N-T-G-A-K-V-V-E-I-I-S-V-K-K-Y-R-G-V-K-N-R-M-P-C-A-G-I-G-D-M-C-V-V-S-V-K-K-G-T-P-E-M-R-K-Q-V-L-L-A-V-V-V-R-Q-K-Q-E-F-R-R-P-D-G-L-H-V-S-F-E-D-N-A-M-V-I-T-D-E-E-G-I-P-K-G-T-D-I-K-G-P-V-A-R-E-V-A-E-R-F-P-K-I-G-T-T-A-S-I-I-V


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-A-R-D-I-G-L-N-I-P-A-P-S-E-E-C-D-D-A-Y-C-P-F-H-G-T-L-P-V-R-G-Q-I-L-V-G-T-V-V-S-S-K-M-D-N-T-V-V-I-E-R-Q-Y-M-K-M-V-S-K-Y-Q-R-Y-E-K-R-R-S-K-I-H-A-H-N-P-A-C-I-S-A-K-V-G-D-I-V-T-I-A-E-C-R-P-I-S-K-T-K-S-Y-V-V-V-K-A-E-V-P-K


### FUNCTION Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends ### SEQUENCE -M-R-S-K-V-E-I-L-P-S-N-L-I-F-H-E-L-I-G-L-E-I-K-V-I-N-S-T-N-P-S-L-T-G-I-R-G-R-V-I-N-E-T-K-N-M-L-V-V-E-N-S-Q-S-R-E-L-K-I-P-K-A-D-S-E-F-L-F-R-I-P-A-E-L-S-E-K-G-R-R-S-D-T-F-V-K-I-Q-G-N-L-L-L-S-Q-P-E-N-R-I-K-N-I-K-K-L-R-K-W-G


### FUNCTION This protein binds specifically to 23S rRNA It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome ### SEQUENCE -M-A-R-I-N-Y-S-I-N-G-D-P-E-T-T-S-K-A-M-G-S-E-L-H-I-S-P-K-K-S-R-E-V-C-C-K-I-K-G-M-K-A-S-E-A-R-K-F-L-E-D-V-I-A-M-K-Q-A-V-P-F-K-K-H-H-D-G-S-G-H-R-K-G-P-M-A-A-G-K-Y-P-I-S-A-S-K-E-I-L-K-V-L-K-N-A-E-S-N-A-E-Y-K-G-L-E-P-A-N-M-Y-I-I-H-A-A-I-Q-R-G-R-V-I-H-G-F-M-P-R-A-R-G-R-A-T-P-K-D-T-E-T-V-N-I-E-M-I-L-S-E-V-R


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-A-K-K-S-S-S-R-L-P-K-R-K-G-E-Y-T-Y-R-G-K-T-V-S-E-L-Q-E-L-S-L-E-E-F-A-E-L-L-P-S-R-E-R-R-S-L-K-R-G-F-T-D-G-Q-K-K-V-L-H-E-F-K-E-G-K-K-I-R-T-H-H-R-D-M-I-I-L-P-E-M-I-G-K-T-I-E-I-H-N-G-K-G-F-V-S-V-D-L-Q-P-E-M-V-G-H-R-F-G-E-F-A-P-T-R-S-R-V-S-H-G-S-A-G-V-G-A-T-R-S-S-K-F-V-P-L-K


### FUNCTION Binds to 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome ### SEQUENCE -M-S-S-I-N-Y-P-F-V-T-E-K-A-M-M-L-L-D-E-N-K-L-Q-F-I-V-D-T-R-S-N-K-K-Q-I-L-E-D-V-E-K-M-Y-G-F-K-V-K-S-V-R-T-M-T-T-M-K-G-M-K-K-A-V-L-A-F-E-E-P-E-A-A-H-E-I-A-T-R-I-G-L-M


### FUNCTION Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase The precise role of the epsilon subunit is unclear ### SEQUENCE -M-V-D-T-A-K-N-T-K-L-F-T-S-Y-G-V-S-T-S-K-T-V-T-P-E-I-A-A-K-L-I-S-K-A-K-R-P-L-L-M-V-G-T-L-T-L-D-P-E-L-L-D-R-V-V-K-I-S-K-T-A-N-I-P-I-A-A-T-G-S-S-L-A-S-L-A-D-K-D-V-D-A-E-Y-I-N-A-H-M-L-G-F-Y-L-T-D-P-N-W-P-G-L-D-G-N-G-N-Y-D-T-V-I-V-L-G-F-K-K-F-Y-I-N-Q-V-L-S-A-A-K-N-F-S-N-L-K-T-I-A-I-E-R-G-Y-I-Q-N-A-T-M-S-F-G-N-L-S-K-A-D-H-Y-A-A-L-D-E-L-I-D-L-L


### FUNCTION Contacts the emerging nascent chain on the ribosome ### SEQUENCE -M-G-G-R-G-M-N-P-A-K-M-K-Q-M-M-K-Q-M-G-I-D-V-K-E-L-K-D-V-K-E-V-I-I-K-T-A-D-S-N-I-V-I-E-N-A-N-V-T-I-M-T-V-Q-G-S-E-T-Y-Q-I-V-G-D-A-K-E-V-P-K-S-L-E-I-P-A-D-D-I-K-L-V-M-E-Q-T-G-V-S-E-E-E-A-R-N-A-L-K-N-S-N-G-D-L-A-E-A-I-V-A-L-S-S-A


### FUNCTION Seems to be required for maximal rate of protein biosynthesis Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA ### SEQUENCE -M-T-L-A-D-L-K-K-P-T-S-R-A-T-P-S-T-E-E-T-F-T-R-V-R-T-P-R-R-E-N-N-E-I-L-A-T-V-E-S-L-L-G-A-N-R-L-R-L-R-C-M-D-G-V-V-R-M-G-R-I-P-G-S-M-K-K-K-T-W-I-R-E-G-D-V-V-I-V-V-P-W-E-F-Q-N-E-K-A-D-V-I-W-K-Y-T-R-P-Q-V-D-W-L-E-R-K-G-Y-L-K-G


### FUNCTION Involved in ribosome biogenesis ### SEQUENCE -M-G-Q-K-I-R-K-C-K-N-C-G-R-Y-T-L-R-E-K-C-P-V-C-G-G-V-T-L-P-A-I-P-A-R-F-S-P-Q-D-P-Y-G-K-Y-R-R-L-A-K-K-G


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-L-K-M-T-V-I-D-A-K-G-L-I-L-G-R-L-A-S-S-V-A-K-Q-L-L-S-G-D-E-K-V-Y-I-I-N-A-E-Q-A-I-I-S-G-S-R-A-A-T-L-R-E-Y-R-E-T-R-E-R-G-A-T-E-F-G-P-Y-F-P-K-R-P-D-R-I-L-K-R-T-I-R-G-M-L-P-Y-K-R-A-R-G-R-D-A-M-S-R-L-K-V-Y-V-G-V-P-Y-E-L-K-G-A-E-T-V-T-I-P-D-A-D-M-R-L-L-S-S-S-R-Y-V-E-L-G-E-V-S-Q-K-M-G-S-K-F


### FUNCTION Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base ### SEQUENCE -M-E-E-K-N-R-V-G-K-K-E-D-R-I-M-G-I-N-N-G-T-G-Q-Q-H-P-K-I-F-L-S-G-S-I-R-G-G-R-Q-L-L-E-I-Y-R-L-M-Y-D-S-L-E-E-A-G-A-D-V-L-S-W-H-V-A-D-P-G-L-E-E-N-E-S-K-M-T-E-Q-E-I-Y-A-R-D-I-G-L-L-T-K-S-D-A-L-I-A-E-V-T-V-P-S-I-G-V-G-Y-E-I-C-R-A-L-V-R-K-I-P-V-L-C-L-H-R-P-E-A-A-V-S-A-M-V-L-G-N-P-D-P-S-L-E-V-R-T-Y-S-D-K-V-A-L-K-E-I-I-V-E-F-A-L-A-L


### FUNCTION Excises hypoxanthine, a deamination product of adenine, from double-stranded DNA Acts on double-stranded DNA containing G/I, T/I, A/I and C/I base pairs, but not on single-stranded inosine-containing DNA Has also minor xanthine DNA glycosylase activity Lacks any detectable uracil-DNA glycosylase activity ### SEQUENCE -M-I-K-R-G-F-P-A-V-L-D-E-N-T-E-I-L-I-L-G-S-L-P-S-D-E-S-I-R-K-Q-Q-Y-Y-G-N-P-G-N-D-F-W-R-L-V-G-H-A-I-G-E-N-L-Q-D-M-A-Y-E-K-K-L-K-T-L-K-H-N-R-I-G-L-W-D-V-F-K-A-G-S-R-E-G-S-Q-D-S-K-I-G-D-E-E-I-N-D-F-S-G-L-K-E-M-V-P-K-L-R-L-I-C-F-N-G-R-K-A-G-E-Y-E-P-L-L-R-G-M-G-Y-E-T-K-V-L-P-S-S-S-G-A-N-R-R-F-S-K-N-R-E-S-E-W-E-A-V-F-R-H


### FUNCTION Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP ### SEQUENCE -M-K-D-K-G-K-L-V-I-W-P-A-Y-I-D-Q-T-R-S-R-S-N-G-R-I-I-S-R-K-N-A-V-K-E-P-H-L-N-E-I-K-D-A-A-K-N-L-G-L-N-P-E-V-E-P-E-K-A-Y-P-K-S-W-W-E-V-S-G-R-V-L-V-D-D-R-G-P-K-S-V-I-A-K-Q-I-S-L-E-I-R-K-K-R-G-K-G-V-P-A-K-T


### FUNCTION General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation ### SEQUENCE -M-E-S-T-I-T-I-E-N-V-V-A-S-T-A-L-A-T-E-F-D-L-V-K-I-M-D-S-G-L-E-G-A-E-Y-N-K-T-K-F-P-G-L-V-Y-R-I-D-N-P-K-A-A-F-L-I-F-T-S-G-K-V-V-C-T-G-A-K-T-I-N-N-A-H-K-A-I-T-N-L-A-N-K-L-K-D-I-G-C-D-K-I-N-L-E-P-E-I-H-V-Q-N-I-V-A-S-A-D-L-K-T-T-L-N-L-N-T-I-A-I-A-F-G-L-E-N-V-E-Y-E-P-E-V-F-P-G-L-I-Y-R-V-E-A-P-K-V-V-V-L-V-F-S-S-G-K-L-V-I-T-G-G-K-C-E-E-D-C-N-G-G-L-R-I-V-R-K-E-F-D-N-L-G-L-L-C


### FUNCTION Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently ### SEQUENCE -M-P-S-Q-G-K-K-Y-E-Y-L-E-H-T-A-D-I-K-F-L-A-Y-G-N-T-L-K-E-V-F-E-N-A-A-L-A-M-F-N-V-I-I-D-T-G-K-V-S-G-E-T-A-R-E-V-C-L-T-S-P-D-L-E-S-L-L-V-D-W-L-S-E-L-L-Y-L-F-E-V-D-E-I-V-F-W-K-F-R-V-E-E-I-R-E-E-E-G-E-Y-S-I-K-A-V-A-S-G-E-Q-Y-Y-P-E-S-H-P-F-E-T-E-I-K-A-V-T-Y-N-Q-L-E-L-E-K-T-A-D-G-W-K-A-Q-V-V-V-D-I


### FUNCTION Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate ### SEQUENCE -M-E-G-R-A-W-K-F-G-D-D-V-D-T-D-A-V-I-P-G-R-Y-L-I-F-N-T-P-G-E-L-A-K-Y-T-F-E-G-V-R-P-D-F-A-K-K-V-H-E-N-D-I-V-V-A-G-S-N-F-G-C-G-S-S-R-E-H-A-P-L-A-L-K-G-S-K-V-S-C-V-I-A-K-S-F-A-R-I-F-F-R-N-A-I-N-I-G-V-P-V-L-E-C-P-N-T-D-R-I-D-D-G-D-E-L-E-V-D-L-S-T-G-D-I-Q-N-I-T-K-G-E-T-Y-Q-A-T-P-L-P-D-F-V-R-E-I-V-D-E-G-G-L-I-E-Y-A-R-K-L-V-S-E-R


### FUNCTION General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation ### SEQUENCE -M-E-P-T-I-T-I-E-N-I-V-A-S-T-R-L-A-E-D-F-D-L-Q-K-L-L-D-T-G-L-K-G-A-V-Y-N-K-N-K-F-P-G-L-V-Y-R-I-E-N-P-K-A-A-F-L-I-F-A-S-G-K-V-V-C-T-G-T-K-N-V-E-N-S-R-I-A-L-F-N-L-A-N-E-L-N-S-I-G-Y-K-G-I-Y-L-K-P-E-I-H-V-Q-N-V-V-A-S-A-N-L-R-T-S-L-N-L-N-A-V-L-S-A-F-G-V-E-N-V-E-Y-E-P-E-V-F-P-G-L-V-Y-K-L-A-D-P-R-V-V-V-L-V-F-R-T-G-K-L-V-I-T-G-G-K-C-P-E-D-C-E-E-G-L-R-I-I-K-T-Q-L-D-N-L-G-L-L-Y


### FUNCTION Probable toxic component of a putative type VII toxin-antitoxin  system, probably an RNase Probably neutralized by cognate antitoxin MA_102 Neutralization may be due to AMPylation by MA_102 ### SEQUENCE -M-K-E-K-R-E-F-R-D-Y-L-S-D-I-F-D-A-I-E-K-I-E-N-F-T-Q-D-I-S-F-D-A-F-V-E-D-E-M-R-V-F-A-V-V-R-A-L-E-I-I-G-E-A-A-K-N-V-P-L-E-I-K-E-N-Y-P-S-V-P-W-K-E-M-A-R-T-R-D-K-L-I-H-S-Y-F-G-V-D-L-N-V-V-W-K-T-V-N-K-N-L-P-P-L-K-D-Q-I-S-E-I-L-K-D-L-G-N-T-S-S


### FUNCTION Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors , playing an important role in chemotaxis ### SEQUENCE -M-A-D-P-G-I-V-M-V-G-I-G-D-C-A-I-A-R-C-P-V-K-I-K-T-S-G-L-G-S-C-V-G-V-T-I-Y-D-R-H-E-K-I-G-G-L-L-H-T-M-L-P-N-I-K-K-A-G-I-K-D-N-P-T-K-F-T-D-A-G-I-E-Y-L-V-A-E-I-I-E-N-G-G-S-R-R-K-L-E-A-K-L-V-G-G-S-S-M-F-E-N-S-H-M-N-I-G-E-R-N-I-K-S-A-K-E-T-L-K-K-L-G-L-E-I-I-A-E-D-T-G-K-N-Y-G-R-T-I-I-F-D-T-L-T-G-D-L-L-I-K-T-M-L-R-G-D-K-V-I


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-A-E-K-K-N-E-Q-E-I-Q-Q-E-L-Q-R-L-I-A-E-I-N-R-L-Q-G-Q-M-E-A-I-N-A-Q-I-D-L-I-E-S-S-I-S-E-L-N-R-V-E-E-T-L-K-G-V-K-E-L-E-G-D-E-E-V-L-V-P-V-G-A-Q-S-F-V-R-A-C-V-T-D-T-E-R-V-I-V-G-I-G-A-G-V-A-V-E-R-T-I-D-E-A-L-E-S-I-D-D-Q-R-Q-E-L-E-K-A-R-A-E-A-Q-Q-K-L-Q-E-L-A-Q-E-L-Q-E-K-Q-R-K-A-Q-E-L-A-Q-Q-L-E-G-A-Q-R-I-A-Q-Q-S-G-G-G


### FUNCTION The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis ### SEQUENCE -M-Y-K-Q-V-I-V-V-R-G-D-L-K-L-S-R-G-K-L-A-A-Q-V-A-H-A-S-L-G-A-F-L-R-A-K-E-S-G-A-P-V-E-E-W-L-R-E-G-Q-K-K-V-V-L-K-C-K-D-K-E-E-L-L-E-L-H-E-L-A-K-R-R-G-L-P-S-F-L-V-R-D-A-G-L-T-E-L-E-P-G-T-V-T-C-L-G-I-G-P-E-R-E-E-E-I-D-R-V-T-G-D-L-P-L-L-R


### FUNCTION This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA ### SEQUENCE -M-I-L-G-E-Y-V-L-R-D-L-F-P-D-L-D-E-D-Q-Y-Q-P-A-G-I-D-L-K-L-D-R-V-F-R-L-E-G-R-G-A-L-L-E-G-D-D-K-R-L-P-E-Y-R-E-V-E-T-E-G-G-V-F-E-L-E-P-N-V-P-Y-V-L-E-L-A-P-E-L-E-I-P-E-D-T-A-V-L-F-L-P-R-S-T-L-L-R-S-G-V-S-V-H-T-A-L-G-D-P-G-F-R-G-K-I-R-V-L-A-V-N-H-H-A-A-P-Y-R-I-A-H-G-E-R-V-V-Q-A-V-F-L-R-A-E-D-A-G-R-Y-E-G-D-Y-G-R


### FUNCTION Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP ### SEQUENCE -M-A-E-T-P-T-V-K-L-K-G-K-D-R-I-V-V-W-P-A-Y-F-D-A-D-R-S-R-S-E-G-R-K-V-P-K-R-L-A-V-R-N-P-R-L-T-E-L-R-H-I-A-E-K-L-G-L-N-P-K-V-Q-R-D-K-R-Y-P-K-R-W-W-D-D-K-G-R-L-I-V-D-K-V-E-S-K-R-K-T-L-L-M-I-A-E-K-L-K-E-R-R-E-S


### FUNCTION Involved in the maturation of  hydrogenases Required for nickel insertion into the metal center of the hydrogenase ### SEQUENCE -M-H-E-L-S-V-A-Q-S-V-L-E-T-V-L-D-V-A-R-K-R-G-A-E-R-V-L-S-V-R-L-R-I-G-E-F-T-L-L-N-P-E-Q-L-R-F-C-L-E-V-L-A-E-G-T-P-V-E-G-A-K-F-E-I-E-I-E-R-G-Y-F-K-C-A-E-C-G-H-R-W-R-P-E-D-E-S-L-K-D-P-S-L-H-T-A-F-D-L-S-E-L-T-E-L-L-D-L-K-C-P-K-C-G-S-R-A-V-K-L-D-G-G-D-A-C-S-I-E-S-V-R-L-E-V-P-G-E-Q-H-A-Q-G


### FUNCTION Transcriptional regulator ### SEQUENCE -M-N-K-G-E-D-N-L-V-R-T-S-I-T-V-P-E-Q-L-L-Q-K-V-N-E-L-I-A-S-G-Y-F-A-S-R-S-E-I-F-R-Q-A-L-R-E-Y-L-Q-R-I-E-W-T-E-R-V-G-D-E-E-Y-F-G-A-L-T-Y-V-F-Q-H-E-R-A-E-P-E-L-V-K-V-Q-H-E-F-T-D-V-I-I-S-T-T-H-I-H-V-S-P-E-K-C-L-E-V-L-L-L-Q-G-P-G-K-R-I-A-E-L-A-K-R-I-R-G-V-R-G-V-E-Q-A-K-L-T-V-V-S-S-E-G-E


### FUNCTION Involved in allosteric regulation of aspartate carbamoyltransferase ### SEQUENCE -M-I-V-A-L-K-V-K-R-I-E-M-G-T-V-L-D-H-L-P-P-G-T-A-P-Q-I-M-R-I-L-D-I-D-P-T-E-T-T-L-L-V-A-I-N-V-E-S-S-K-M-G-R-K-D-I-L-K-I-E-G-K-I-L-S-E-E-E-A-N-K-V-A-L-V-A-P-N-A-T-V-N-I-V-R-D-Y-S-V-A-E-K-F-Q-V-K-P-P-E-R-V-E-G-F-L-R-C-P-N-P-N-C-I-T-N-D-E-R-E-P-V-D-T-V-F-V-R-E-S-K-K-P-L-E-Y-R-C-R-Y-C-E-R-T-V-R-E-D-Q-I-R-E-L-I-R-P-S


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-V-E-Y-A-H-S-K-P-V-D-P-E-E-W-T-V-I-D-A-E-N-A-V-L-G-R-L-A-S-V-V-A-K-R-I-L-K-G-E-R-I-A-V-I-N-T-E-K-A-I-I-T-G-K-K-N-T-I-K-E-E-W-L-Q-K-I-Q-R-G-D-P-K-K-G-P-F-Y-P-R-R-P-D-L-I-F-R-R-V-V-R-G-M-L-P-W-K-T-K-R-G-R-E-A-F-K-R-L-R-A-Y-I-G-T-P-R-W-V-E-E-A-N-I-E-P-E-R-V-A-E-A-D-M-S-R-L-G-H-L-W-Y-V-T-L-G-E-L-S-E-E-L-G-Y-Q-M-P-G-G-Q


### FUNCTION Located on the platform of the 30S subunit ### SEQUENCE -M-A-E-K-E-G-K-K-E-K-K-E-R-W-G-I-A-H-I-Y-A-S-F-N-N-T-I-I-T-I-T-D-L-T-G-A-E-T-F-A-R-W-S-G-G-M-V-V-D-A-D-R-E-E-S-S-P-Y-A-A-M-K-A-A-R-R-A-A-E-E-A-M-E-K-G-I-T-A-V-H-V-K-V-R-A-P-G-G-H-G-P-K-T-P-G-P-G-A-Q-A-A-I-R-A-L-A-R-A-G-L-K-I-G-R-I-E-D-V-T-P-I-P-H-D-G-T-R-R-P-G-G-K-R-G-R-R-V


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit ### SEQUENCE -M-G-D-P-K-R-P-R-K-K-Y-E-T-P-R-H-P-W-E-A-E-R-L-E-Y-E-R-K-L-M-R-K-Y-G-L-R-R-K-K-E-L-W-R-H-Q-T-Q-L-K-R-W-R-E-R-A-K-E-L-M-A-R-T-D-P-E-A-Q-R-E-R-E-A-L-F-R-K-L-Y-D-L-G-I-L-D-K-K-P-E-E-A-T-L-D-D-I-L-R-L-T-V-E-D-V-L-E-R-R-L-Q-T-I-V-Y-R-K-G-L-A-K-T-P-L-Q-A-R-Q-L-V-V-H-R-H-I-A-I-G-D-R-I-V-T-V-P-S-Y-L-V-S-R-E-E-E-E-E-V-D-Y-S-P-Y-S-P-L-K-D-E-D-H-P-I-R-C-E-A-R-G-E-S-P-E-E-T-A-A-E-E


### FUNCTION Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA In the 70S ribosome it contacts the 23S rRNA , connecting the 2 subunits ### SEQUENCE -M-A-D-D-E-V-K-P-I-V-R-I-A-D-V-D-L-D-G-H-K-K-V-P-Y-A-L-T-G-I-K-G-I-G-I-R-M-A-Y-A-I-C-R-E-L-G-L-D-E-E-K-K-L-G-E-L-S-D-E-E-I-E-R-I-E-E-E-I-K-K-L-S-E-G-E-S-N-I-P-S-W-M-Y-N-R-Q-K-D-Y-E-T-G-E-D-M-H-L-V-G-A-E-L-E-M-T-V-K-Q-D-I-D-R-L-K-K-I-R-A-Y-R-G-I-R-H-E-L-G-L-P-V-R-G-Q-R-T-K-S-S-F-R-R-G-R-T-V-G-V-K-K-K-Q


### FUNCTION Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A ### SEQUENCE -M-T-V-V-L-R-L-P-R-E-L-R-P-E-L-R-R-P-W-G-T-L-Y-P-R-P-S-I-K-T-Y-R-R-L-H-E-E-S-E-V-L-I-T-V-G-D-M-T-T-R-S-F-L-R-C-S-I-R-P-D-V-A-V-V-D-R-K-M-L-R-T-V-P-V-D-P-G-N-K-F-P-V-T-L-D-V-N-N-P-P-G-T-I-T-R-E-A-W-D-T-V-R-R-G-I-D-Y-A-L-D-G-D-A-T-L-I-D-V-T-G-E-E-D-L-L-A-I-P-A-I-L-I-A-P-E-N-S-I-V-C-Y-G-L-P-G-E-G-M-V-A-A-R-V-T-Q-H-L-K-D-S-V-L-R-L-L-T-R-F-R-G-Y-D-E-W-K-S-R-S-W-I-S-G-I-T-P-C-C-T-A-K-R


### FUNCTION Catalyzes the hydrolysis of inorganic pyrophosphate  forming two phosphate ions ### SEQUENCE -M-M-N-L-W-K-D-L-E-P-G-P-N-P-P-D-V-V-Y-A-V-I-E-I-P-R-G-S-R-N-K-Y-E-Y-D-E-E-R-G-F-F-K-L-D-R-V-L-Y-S-P-F-H-Y-P-L-D-Y-G-F-I-P-R-T-L-Y-D-D-G-D-P-L-D-I-L-V-I-M-Q-D-P-T-F-P-G-C-V-I-E-A-R-P-I-G-L-M-K-M-L-D-D-S-D-Q-D-D-K-V-L-A-V-P-T-E-D-P-R-F-K-D-V-K-D-L-D-D-V-P-K-H-L-L-D-E-I-A-H-M-F-S-E-Y-K-R-L-E-G-K-E-T-E-V-L-G-W-E-G-A-D-A-A-K-E-A-I-V-H-A-I-E-L-Y-E-E-E-H-G


### FUNCTION CRISPR  Functions as a ssRNA-specific endoribonuclease Involved in the integration of spacer DNA into the CRISPR cassette ### SEQUENCE -M-G-V-L-G-G-P-S-P-R-L-R-L-Y-V-Y-D-F-K-E-P-G-G-E-A-E-R-R-K-L-R-E-L-L-E-S-H-G-A-F-R-L-Q-Y-S-T-Y-A-L-L-A-E-P-E-V-H-A-R-V-L-R-R-V-V-A-R-V-D-F-E-E-G-D-S-L-I-V-V-P-M-C-R-R-C-L-R-V-A-R-W-V-D-A-E-G-V-R-G-L-R-F


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-T-L-M-D-P-L-A-D-A-M-A-T-I-K-N-N-E-M-V-G-N-K-E-C-V-I-E-P-A-S-K-L-I-G-R-V-L-K-V-M-Q-E-Y-G-Y-I-G-S-F-E-F-I-D-D-G-R-S-G-K-F-L-V-K-L-V-G-R-I-N-D-C-G-V-I-K-P-R-H-P-V-K-K-D-E-W-E-Y-W-E-Q-R-Y-L-P-A-R-D-F-G-L-L-I-V-T-T-P-E-G-V-M-S-H-Y-E-A-K-E-R-G-I-G-G-R-L-L-A-Y-V-Y


### FUNCTION Binds 16S rRNA, required for the assembly of 30S particles ### SEQUENCE -M-A-R-R-E-F-G-K-G-A-R-R-C-R-R-C-G-D-T-H-G-V-I-Q-K-Y-G-I-M-L-C-R-Q-C-F-R-E-V-A-E-K-M-G-F-K-K-Y-N


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-S-V-V-D-E-E-T-R-R-K-I-L-E-D-W-E-S-N-P-M-R-K-P-R-V-G-K-V-T-V-N-I-G-V-G-E-S-G-D-R-L-Q-K-A-Y-E-L-L-Q-E-L-T-G-Q-K-P-V-Y-T-R-A-K-Q-T-N-P-S-F-G-I-R-R-G-Q-P-I-G-V-K-V-D-L-R-R-E-Q-A-I-E-F-L-D-W-T-L-D-A-V-D-R-E-L-H-E-S-Q-F-D-E-F-G-N-V-C-F-G-L-E-E-H-I-A-L-E-G-V-E-Y-D-P-E-I-G-I-F-G-M-D-I-A-V-T-L-E-R-P-G-F-R-V-M-R-R-R-R-C-R-R-P-V-P-R-R-H-R-L-T-K-E-E-G-I-V-F-M-E-E-E-F-D-V-E-V-L-P


### FUNCTION One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit ### SEQUENCE -M-R-W-T-K-S-S-Q-P-R-K-Q-R-K-A-F-F-N-A-P-L-H-K-R-Q-K-L-M-S-A-T-L-H-P-E-L-R-K-K-F-N-R-R-S-L-P-V-R-R-G-D-M-V-R-I-M-R-G-D-F-K-G-H-E-G-E-V-V-E-V-D-L-K-R-L-R-I-Y-V-E-G-A-T-I-E-R-A-N-G-E-K-V-Y-Y-P-I-H-P-S-N-V-M-I-I-E-P-N-L-D-D-P-M-R-R-K-I-I-E-R-S-G-G-T-P-E-V-E-A-V-P-E-K-S-E-E-E-K-E-E-K-E-K-E-E-E-K-S-E-E


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-K-A-I-K-A-K-S-P-H-A-A-L-P-V-G-A-R-L-V-C-A-D-N-T-G-A-R-E-L-Q-I-I-A-V-K-G-Y-K-G-V-R-R-R-L-P-N-A-G-I-G-D-M-V-V-C-S-V-K-E-G-T-P-D-M-R-K-E-V-V-N-A-V-I-V-R-Q-R-K-E-Y-R-R-P-D-G-T-R-V-K-F-E-D-N-A-A-V-I-V-T-P-D-G-A-P-R-G-S-E-I-R-G-P-V-A-K-E-A-A-E-R-W-P-R-I-G-S-I-A-S-I-I-V


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-T-G-E-Y-R-M-A-K-D-I-G-L-G-V-K-P-P-R-R-E-C-D-D-P-N-C-P-F-H-G-N-L-R-V-R-G-M-I-L-E-G-V-V-V-S-D-R-M-D-K-T-V-I-V-E-R-E-Y-Y-R-Y-D-R-K-Y-E-R-W-E-R-R-R-S-R-I-P-A-H-N-P-P-C-I-D-A-Q-E-G-D-K-V-R-I-A-E-C-R-P-L-S-K-T-K-S-F-V-V-I-E-V-L-E-R-A-Q-E-R


### FUNCTION Fluoride-specific ion channel Important for reducing fluoride concentration in the cell, thus reducing its toxicity ### SEQUENCE -M-V-K-I-G-A-R-E-L-A-A-V-A-I-G-G-A-L-G-A-V-C-R-Y-L-L-S-G-L-V-P-Q-V-R-G-F-P-M-G-T-V-L-V-N-V-L-G-S-F-V-L-G-F-L-T-W-S-T-M-L-G-L-R-L-S-P-E-V-R-A-L-A-T-V-G-F-C-G-G-L-T-T-L-S-T-M-A-Y-E-T-V-E-L-L-K-A-S-P-V-L-S-I-L-Y-L-T-A-N-V-V-L-G-I-A-A-V-L-G-G-M-A-A-A-H-V-V-W-S-G-R-A


### FUNCTION Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate ### SEQUENCE -M-R-W-S-G-R-A-H-V-F-G-D-D-V-D-T-D-Q-I-I-P-G-R-C-L-R-R-V-S-Y-D-E-L-G-R-Y-A-M-T-G-A-D-P-E-F-P-E-K-V-R-E-G-D-V-I-V-A-G-K-N-F-G-C-G-S-S-R-E-Q-A-V-M-A-L-Q-Q-A-G-V-A-C-V-V-A-R-S-F-A-R-I-F-Y-R-N-A-I-N-R-G-L-P-T-V-E-A-E-E-D-P-T-E-V-V-E-D-G-N-R-V-T-V-D-L-D-E-L-V-L-R-A-G-S-E-E-V-P-L-R-E-P-P-E-F-A-L-Q-A-W-R-E-G-G-L-L-E-L-V-K-K-N-P-D-K-P-P-W-R-D


### FUNCTION Binds double-stranded DNA tightly but without sequence specificity It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture However, it does not significantly compact DNA Binds rRNA and mRNA in vivo May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes ### SEQUENCE -M-A-E-E-N-V-I-Y-V-G-N-K-P-V-T-N-Y-V-L-A-V-M-T-Q-F-S-E-G-A-D-E-V-K-L-V-A-R-G-R-A-I-S-R-A-V-D-V-A-E-F-I-R-N-N-V-M-P-E-V-E-V-K-D-I-E-I-G-T-E-E-I-E-T-E-E-G-D-T-I-S-V-S-T-I-A-I-T-L-A-K-P-S-E


### FUNCTION Catalyzes the formation of CDP-2,3-bis- and CTP This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids ### SEQUENCE -M-V-E-M-G-S-G-A-W-L-E-L-G-K-G-L-W-F-I-L-P-A-Y-I-A-N-L-S-A-C-L-F-G-G-G-R-P-L-D-F-G-K-K-L-S-D-G-R-R-L-L-G-D-G-V-T-I-R-G-F-I-V-G-V-L-A-G-A-V-V-G-L-G-E-G-L-V-V-G-D-P-W-K-A-G-D-G-F-I-L-G-L-G-A-M-A-G-D-A-V-G-S-F-V-K-R-R-I-G-L-E-R-G-A-P-A-P-V-L-D-Q-L-D-F-F-V-G-A-V-L-L-Y-Y-L-V-Y-G-W-H-P-P-G-W-V-L-V-G-L-A-I-L-T-L-A-L-H-W-L-T-N-V-I-G-Y-L-L-K-L-K-E-V-P-W


### FUNCTION Broad-specificity nucleoside monophosphate  kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates ### SEQUENCE -M-K-I-A-I-T-G-T-P-G-V-G-K-T-T-V-C-E-A-L-R-D-L-G-F-D-V-V-H-L-N-K-V-A-R-E-M-D-A-I-L-E-E-D-E-Q-R-Q-A-K-V-V-D-L-H-A-L-R-R-Y-V-E-E-W-E-P-E-S-D-P-A-F-V-E-S-H-Y-A-H-L-M-P-T-D-L-V-I-V-L-R-L-H-P-S-E-L-E-R-R-L-K-E-K-G-Y-P-P-E-K-I-A-E-N-L-E-A-E-F-V-G-V-C-Y-G-E-A-V-E-V-R-S-E-G-C-F-I-R-P-P-E-D-V-I-Q-V-N-V-T-G-L-S-R-A-E-A-A-D-R-V-L-E-A-V-N-H-R-R-G-D-D-V-D-W-L-S-D-E-E-A-Q-R-T-V-E-R-Y-L-K-Y-R


### FUNCTION Produces ATP from ADP in the presence of a proton gradient across the membrane ### SEQUENCE -M-G-V-E-E-L-E-R-K-I-L-E-D-A-E-K-E-A-E-E-I-L-E-E-A-K-R-D-A-E-R-I-R-E-K-A-E-R-E-A-E-E-V-R-R-E-I-L-D-R-A-R-R-E-A-E-T-R-R-R-R-E-I-A-Q-A-K-L-E-I-R-Q-E-R-L-R-V-K-E-E-Y-I-E-K-A-I-E-R-A-E-E-K-I-R-E-L-A-E-E-G-R-K-E-Y-L-E-F-L-K-R-S-A-I-E-A-V-N-A-I-S-S-D-E-V-V-L-R-A-N-E-N-D-L-M-L-L-D-E-M-L-S-E-I-R-D-E-T-G-K-D-V-E-L-G-E-P-V-E-A-V-G-G-V-I-A-E-S-K-D-G-S-E-A-Y-D-N-T-V-D-A-R-L-R-R-R-R-S-E-I-V-R-R-V-S-E-T-L-F-G-G


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-A-E-E-R-S-K-D-D-I-P-D-W-W-E-K-E-W-V-E-F-R-Y-R-G-Y-T-L-G-E-L-M-K-M-P-I-E-E-F-I-E-L-L-P-A-R-Q-R-R-S-L-K-R-G-L-P-S-R-H-K-K-L-L-R-K-V-R-R-A-R-R-L-L-R-R-G-K-K-P-P-V-I-R-T-H-C-R-D-M-I-I-L-P-E-M-V-G-L-T-I-A-V-Y-N-G-K-E-F-K-E-V-K-I-E-P-E-M-I-G-H-Y-L-G-E-F-A-K-T-R-K-T-V-E-H-G-G-I-G-A-T-R-S-S-L-F-V-P-L-K


### FUNCTION eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA ### SEQUENCE -M-V-E-Y-D-Y-E-E-L-L-E-R-A-Y-E-Q-L-P-E-E-V-L-E-D-R-R-F-E-M-P-K-P-K-V-S-V-E-G-K-T-T-V-I-R-N-F-K-E-I-S-K-K-L-D-R-D-P-E-H-I-T-K-Y-F-L-K-E-L-G-T-A-G-H-V-D-G-G-R-L-I-L-H-G-V-Y-H-P-K-L-V-E-E-E-L-K-N-Y-V-E-E-F-V-L-C-P-E-C-G-K-P-D-T-K-L-V-R-E-D-R-Q-W-I-L-K-C-E-A-C-G-A-W-S-S-V-R-R-L-K


### FUNCTION Contacts the emerging nascent chain on the ribosome ### SEQUENCE -M-F-P-G-G-K-I-D-P-R-K-L-Q-R-L-M-R-E-M-G-M-E-Q-E-P-I-S-G-V-E-R-V-E-I-H-L-K-D-G-S-K-L-V-F-E-K-P-Q-V-I-R-M-K-I-M-N-Q-E-F-Y-Q-V-A-G-K-A-K-R-E-K-P-E-E-E-P-F-T-D-E-D-V-K-L-V-A-E-Q-A-G-V-S-E-E-E-A-R-K-A-L-E-E-T-G-G-D-L-A-E-A-I-M-R-L-Q-G-E


### FUNCTION This protein binds specifically to 23S rRNA It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome ### SEQUENCE -M-P-K-T-K-H-W-H-Y-S-I-P-P-E-E-L-D-D-E-R-T-A-K-A-F-I-R-E-L-R-I-S-P-K-H-A-R-E-I-C-R-A-I-R-G-M-P-L-D-R-A-K-E-F-L-R-R-V-I-R-K-E-E-A-V-P-F-R-K-H-K-K-K-V-P-H-R-R-Q-I-R-P-G-W-D-A-G-R-F-P-E-K-A-A-R-E-I-L-R-V-L-E-H-A-E-A-N-A-E-Y-K-G-L-D-T-D-R-L-Y-I-K-H-I-A-A-H-K-G-R-V-I-R-G-W-I-P-R-A-F-G-R-A-T-P-F-N-T-P-T-T-H-I-E-V-I-L-E-E-R


### FUNCTION General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation ### SEQUENCE -M-E-I-Q-N-I-V-A-S-V-D-L-K-G-E-V-N-L-D-E-C-S-V-I-L-Q-G-E-Y-E-P-E-Q-F-P-G-L-V-Y-R-L-E-D-I-G-T-V-V-L-I-F-R-S-G-K-M-V-C-T-G-A-K-N-R-E-Q-I-Y-K-S-V-E-R-V-R-E-D-L-E-K-K-C-G-V-K-F-H-G-E-P-E-V-E-I-Q-N-I-V-A-S-I-D-F-H-V-P-L-D-L-D-T-I-A-E-V-L-V-G-D-E-D-V-E-G-I-E-Y-E-P-E-Q-F-P-G-L-V-L-R-L-R-E-P-K-V-A-M-L-L-F-Y-S-G-K-A-V-C-T-G-A-K-T-E-E-E-P-E-K-A-V-K-K-I-A-E-K-I-E-K-Y-G-L-K-L-T-G


### FUNCTION Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP May hydrolyze nucleoside diphosphates with lower efficiency ### SEQUENCE -M-P-H-N-V-V-L-T-G-R-P-G-I-G-K-T-T-V-C-L-K-V-R-N-V-L-E-E-E-G-Y-T-V-G-G-I-Y-C-P-E-I-R-E-G-G-R-R-I-G-F-E-I-V-D-L-T-E-G-D-R-Y-L-L-A-R-E-G-A-S-G-P-R-V-G-R-Y-G-V-F-V-D-N-L-E-R-A-A-E-S-I-E-R-A-V-K-R-T-D-V-V-I-V-D-E-V-G-P-M-E-L-K-S-N-A-F-V-D-A-V-R-R-A-A-D-A-H-T-P-A-I-F-V-V-H-E-R-S-R-H-P-V-V-V-D-L-R-E-E-R-P-D-V-V-R-F-R-V-T-L-S-N-R-D-E-L-S-D-R-I-L-E-H-V-L-E-W-L-E-E-R


### FUNCTION Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors ### SEQUENCE -M-P-K-E-E-V-E-V-L-I-E-G-G-K-A-D-P-G-P-P-L-G-P-A-L-G-P-L-G-V-N-I-Q-E-V-V-E-E-I-N-R-K-T-K-D-F-K-G-M-E-V-P-V-K-I-I-V-D-T-E-T-R-E-F-E-V-K-V-G-S-P-P-T-S-A-I-I-K-S-E-L-G-I-D-K-G-A-H-E-P-R-H-E-T-V-G-D-L-S-M-E-Q-V-I-K-I-A-K-M-K-F-D-D-L-L-S-Y-D-L-K-T-A-A-K-E-I-L-G-T-C-G-S-M-G-V-T-V-E-G-K-D-P-K-E-V-Q-K-E-I-D-E-G-K-W-D-D-L-F-E-K-Y-E-E-E-E-E


### FUNCTION Essential subunit of the Sec protein translocation channel SecYEG Clamps together the 2 halves of SecY May contact the channel plug during translocation ### SEQUENCE -M-S-T-Y-E-E-L-I-S-L-L-R-D-C-K-R-V-L-R-A-A-R-K-P-T-W-D-E-Y-I-E-S-A-K-I-A-G-L-G-I-L-I-V-G-G-V-G-F-L-I-R-V-I-V-Q-L-I-E-L-Y-T


### FUNCTION Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs ### SEQUENCE -M-E-L-E-P-R-T-V-V-L-R-L-G-H-R-R-E-R-D-K-R-I-T-T-H-V-C-L-T-A-R-A-F-G-A-A-G-V-L-I-S-G-D-H-D-E-S-V-I-E-S-V-E-D-V-V-E-R-W-G-G-P-F-T-V-Q-W-V-G-N-W-R-R-V-I-K-D-W-K-R-S-G-G-S-V-V-H-L-T-M-Y-G-L-H-I-D-D-V-I-G-E-L-R-G-E-N-E-L-L-V-I-V-G-A-G-K-V-P-A-E-V-F-E-L-S-D-Y-N-V-A-I-G-H-Q-P-H-S-E-V-A-A-L-A-V-F-L-D-R-L-Y-E-G-K-E-L-H-R-E-F-E-R-A-R-L-R-V-V-P-S-E-K-G-K-K-V-E-R-L


### FUNCTION Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate ### SEQUENCE -M-R-D-V-I-R-G-R-A-W-V-F-G-D-D-I-D-T-D-Q-I-I-P-G-R-Y-L-T-T-Q-D-P-E-E-L-A-K-H-V-M-E-G-A-D-P-E-F-P-E-K-V-R-E-G-D-V-I-V-A-G-K-N-F-G-C-G-S-S-R-E-H-A-P-I-A-L-K-A-A-G-I-A-C-V-V-T-R-S-F-A-R-I-F-Y-R-N-A-I-N-L-G-L-P-L-V-V-C-P-G-V-D-D-A-F-E-D-G-Q-G-I-E-V-N-L-R-E-G-Y-V-R-N-L-D-T-G-E-E-L-E-A-K-P-L-P-D-F-M-M-R-I-L-E-A-G-G-L-V-E-L-I-K-R-E-G-P-R-A-F-E-G


### FUNCTION Functions by promoting the formation of the first peptide bond ### SEQUENCE -M-D-V-A-V-K-K-V-E-V-R-Q-L-K-K-G-K-Y-I-M-I-D-D-E-P-C-K-I-V-E-Y-T-T-S-S-P-G-K-H-G-S-A-K-A-R-I-V-A-V-G-L-F-D-G-K-K-R-T-L-T-K-P-V-D-A-K-V-D-V-P-V-I-E-R-K-T-A-Q-V-V-S-D-M-G-D-T-V-Q-L-M-D-M-E-T-Y-E-T-F-E-V-Q-K-P-E-D-E-E-L-A-S-Q-L-E-P-G-T-M-V-E-Y-M-E-A-A-G-K-R-K-I-V-G-I-K-E-E-E


### FUNCTION Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase The precise role of the epsilon subunit is unclear ### SEQUENCE -M-P-L-P-R-D-P-T-L-I-Y-T-D-K-A-E-V-A-R-A-P-V-L-K-M-V-F-R-R-A-N-D-S-L-M-I-V-G-P-R-A-V-E-D-E-E-W-R-E-L-L-M-K-L-R-E-E-F-R-M-S-A-V-C-T-A-P-Y-K-G-N-D-L-G-R-K-M-G-I-V-E-A-A-T-L-L-Q-R-D-A-P-V-L-G-V-H-P-D-L-V-V-F-T-G-S-R-T-D-V-T-D-R-V-L-Q-G-L-R-H-A-R-P-D-L-V-K-V-S-L-N-P-E-Y-C-P-S-A-D-Y-S-L-P-T-V-K-R-D-Q-F-L-Q-E-L-K-A-L-V-G-I


### FUNCTION Binds double-stranded DNA tightly but without sequence specificity It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture However, it does not significantly compact DNA Binds rRNA and mRNA in vivo May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes ### SEQUENCE -M-A-E-E-E-N-V-V-Y-V-G-S-K-P-V-M-N-Y-V-L-A-C-I-T-Q-F-N-E-G-A-N-E-V-R-I-K-A-R-G-R-A-I-S-R-A-V-D-V-A-E-I-V-R-N-R-F-M-P-E-V-E-V-K-D-I-K-I-G-T-E-E-L-E-T-E-E-G-D-T-V-N-V-S-T-I-E-I-V-L-E-K-P-V


### FUNCTION With S4 and S5 plays an important role in translational accuracy Located at the interface of the 30S and 50S subunits ### SEQUENCE -M-P-G-K-K-S-P-A-G-E-F-A-A-R-K-L-R-E-K-R-K-K-F-R-W-K-D-E-R-Y-K-R-R-M-L-K-L-D-E-K-A-D-P-L-E-G-A-P-Q-A-R-G-I-V-L-E-K-V-G-V-E-A-K-Q-P-N-S-A-I-R-K-C-V-R-V-Q-L-I-K-N-G-K-Q-V-T-A-F-C-P-G-D-G-A-I-D-Y-I-D-E-H-D-E-V-V-I-E-G-I-G-G-P-K-G-R-A-K-G-D-I-P-G-V-R-Y-K-V-V-K-V-N-D-V-A-L-S-E-L-L-K-G-K-I-E-K-P-M-R


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit Is located at the subunit interface close to the decoding center ### SEQUENCE -M-E-G-N-P-Y-L-D-R-L-Y-E-M-K-V-F-G-K-W-D-P-T-E-V-E-V-R-D-P-G-L-K-D-Y-I-C-L-K-P-M-Y-L-P-H-T-G-G-R-H-A-K-K-R-F-A-K-A-E-V-P-I-V-E-R-L-I-N-R-V-M-R-T-E-K-N-T-G-K-K-H-L-A-Y-N-I-V-K-R-A-F-D-I-I-H-E-R-T-G-E-N-P-I-Q-V-L-V-Q-A-L-E-N-A-A-P-R-E-E-T-T-T-I-I-Y-G-G-I-S-Y-H-E-A-V-D-S-S-P-Q-R-R-L-D-I-A-L-R-L-I-T-E-G-A-Q-Q-R-A-F-R-N-P-K-P-I-E-E-C-L-A-E-E-I-I-A-A-A-R-Y-D-T-E-C-H-S-I-R-R-K-E-E-I-E-R-I-A-E-A-A-R


### FUNCTION Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in Mjannaschii 16S rRNA It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3- ### SEQUENCE -M-I-V-L-H-A-R-D-C-D-P-K-A-C-T-A-L-R-A-H-R-M-G-L-V-E-L-T-R-H-P-G-D-V-P-T-G-A-V-V-L-D-P-T-V-E-K-A-L-S-R-E-D-R-D-A-A-L-E-R-G-L-V-A-V-D-C-S-W-E-H-V-H-R-Y-F-G-P-L-R-R-R-C-R-H-R-I-L-P-Y-L-I-A-A-N-P-V-N-Y-G-K-P-C-K-L-S-T-V-E-A-L-A-A-A-L-Y-I-L-G-F-R-R-E-A-E-E-F-I-S-R-F-K-W-G-P-A-F-L-E-L-N-R-E-R-L-E-A-Y-R-R-A-E-T-S-A-E-V-V-R-V-Q-E-E-F-L-P-D-G-L


### FUNCTION Guanylyltransferase that catalyzes the activation of -lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor ### SEQUENCE -M-R-F-V-V-P-F-A-D-R-G-D-R-K-T-R-L-S-S-C-M-D-E-E-T-R-E-R-F-A-L-A-M-L-R-H-V-V-R-V-L-S-K-F-G-E-V-E-V-V-T-P-D-S-S-L-S-V-P-G-T-K-V-R-R-S-D-A-S-L-D-E-L-P-L-P-D-G-E-F-G-L-V-M-S-D-L-P-L-L-S-E-E-D-V-E-R-A-L-E-G-L-K-D-A-D-V-V-L-C-P-S-R-R-G-G-T-S-G-V-F-V-R-K-G-V-R-F-R-P-T-F-G-G-V-S-F-P-R-N-L-R-R-A-E-K-Q-G-V-E-V-A-V-V-K-S-L-G-F-F-A-D-V-D-E-P-E-D-L-L-D-A-A-L-L-G-R-R-E-V-A-K-I-A-R-S-V-V-E-V


### FUNCTION Catalyzes the conversion of ### SEQUENCE -M-T-A-G-G-R-R-M-S-M-V-D-V-T-G-K-K-E-E-I-R-I-A-E-A-S-G-F-L-R-L-T-E-D-G-V-N-A-V-K-S-G-E-S-H-P-Q-G-K-G-D-P-I-E-V-A-K-V-A-A-I-L-A-V-K-K-T-P-E-L-V-P-H-C-H-P-I-K-I-T-G-V-D-V-D-V-E-V-L-E-D-G-V-K-M-S-V-R-V-K-S-E-G-K-T-G-V-E-M-D-A-L-T-G-L-V-V-G-L-V-T-L-W-D-M-V-K-Y-A-E-K-D-E-E-G-Q-Y-P-H-T-R-I-E-N-V-R-V-V-E-K-I-I-K-E-K-E


### FUNCTION Seems to be required for maximal rate of protein biosynthesis Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA to 40 S ribosomal subunits ### SEQUENCE -M-G-K-R-I-D-D-E-T-L-K-K-I-R-L-P-K-E-G-E-I-F-G-V-V-E-K-M-L-G-N-D-R-V-Q-V-R-C-V-D-G-K-T-R-V-A-R-I-P-G-K-M-R-K-R-V-W-I-R-E-G-D-V-V-L-V-K-P-W-E-F-Q-P-E-R-A-D-V-T-W-R-Y-T-R-V-Q-V-D-W-L-K-R-K-G-K-L-D-E-R-V-T-K-L-L-E-E-I-I-P-G-A


### FUNCTION Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein  and RNA polymerase recruitment Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes ### SEQUENCE -M-Y-A-E-L-G-E-E-D-L-E-V-L-R-D-V-T-L-S-L-L-D-S-E-K-G-V-D-P-E-V-A-K-R-T-V-D-V-I-L-K-R-E-A-I-D-E-E-I-A-E-E-L-G-V-D-P-R-E-V-R-K-V-L-Y-K-L-H-E-R-G-V-V-T-F-R-K-E-R-R-E-E-Y-R-Y-P-V-Y-S-W-R-L-N-L-R-E-V-L-R-R-C-L-E-E-R-R-R-E-L-E-E-V-E-R-A-L-S-N-D-M-S-H-P-M-F-H-C-G-N-D-D-C-P-R-M-S-F-E-E-A-M-E-H-E-F-R-C-P-K-C-G-E-V-L-E-E-V-D-L-T-E-E-R-R-E-L-E-R-L-A-E-E-L-K-V-E-I-R-R-L-E-E-L-R-E-R-L-G


### FUNCTION One of the integral membrane subunits of multisubunit membrane-bound -hydrogenase eha Eha is predicted to form large electron transfer complex and might catalyze energy-driven reduction of low-potential redox carriers ### SEQUENCE -M-K-D-P-G-L-V-A-V-G-V-A-A-A-V-A-F-G-T-A-L-A-L-G-L-P-P-I-Q-R-D-K-P-R-R-K-S-W-E-V-S-A-A-F-P-T-P-V-I-A-A-G-A-T-V-L-V-I-R-V-I-G-Y-H-P-P-I-P-L-A-I-V-G-A-V-V-G-A-L-S-A-A-F-T-A-Y-I-E-K-V-F-P-R-P-E-A-G


### FUNCTION Involved in ribosome biogenesis ### SEQUENCE -M-P-K-R-L-R-R-C-K-E-C-G-E-Y-T-L-Q-R-D-K-C-P-H-C-G-G-D-L-E-V-P-H-P-H-R-F-S-P-E-D-P-Y-G-K-Y-R-R-K-L-K-K-R-V-W-A-E-K-F-G-P-P-S-G-E-G-D


### FUNCTION Binds to 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome ### SEQUENCE -M-A-K-R-Y-G-P-K-I-E-D-P-H-D-V-L-L-Y-P-V-A-T-E-K-A-M-R-L-M-E-A-E-N-K-L-T-F-I-V-R-R-D-A-N-K-P-L-I-K-K-A-V-E-E-L-F-D-V-E-V-E-K-V-N-T-L-I-T-P-T-G-E-K-K-A-Y-V-K-L-K-P-E-Y-R-A-E-D-V-A-V-D-L-G-I-L


### FUNCTION Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends ### SEQUENCE -M-R-V-R-L-S-S-A-L-R-P-R-W-R-Y-V-T-F-K-V-W-S-E-R-V-E-A-L-D-F-G-G-M-K-D-L-V-V-R-A-L-L-S-V-L-G-P-T-G-T-G-R-I-G-P-W-L-V-R-S-Y-R-D-L-N-A-G-I-L-R-V-R-R-G-Q-E-E-E-A-R-A-A-L-S-L-Y-R-R-D-P-K-L-G-R-V-F-I-E-V-L-G-T-S-G-T-I-K-G-A-E-R-Y-L-S-R-I-P-K-W-D-R-E-R-V-G-N-R-E-F-V-L-Y-E-N-G-E-V-D-V-V-E-D-G-R-I-V-A-F-A-S-F-E-C-P-L-P-E-E-N-R-G


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-A-Q-N-V-E-Q-Q-V-A-Q-L-Q-Q-L-Q-Q-Q-L-S-S-I-V-A-Q-K-Q-Q-L-E-L-Q-L-R-E-I-E-R-A-L-K-E-L-D-E-I-E-E-D-T-K-V-Y-K-T-V-G-G-L-L-I-E-A-D-R-D-E-V-K-E-E-L-E-D-R-K-E-T-L-E-L-R-V-K-T-L-E-K-Q-E-K-R-L-Q-Q-Q-I-E-N-L-Q-K-R-L-Q-K-A-L-Q-Q-A-E-G-G-G-G-A-G-A-A


### FUNCTION Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-uracil with 3,4-dihydroxy-2-butanone 4-phosphate This is the penultimate step in the biosynthesis of riboflavin ### SEQUENCE -M-S-E-I-R-L-G-L-V-V-T-E-F-N-R-E-I-T-Y-A-M-E-E-L-A-V-Q-H-A-K-D-L-G-A-K-V-V-E-R-V-L-V-P-G-S-F-E-V-P-L-A-V-R-K-L-L-E-R-D-D-I-D-A-V-V-T-L-G-A-I-I-K-G-D-T-D-H-D-Q-A-I-A-Q-Q-A-F-R-K-I-Q-D-L-M-V-E-Y-G-K-P-V-A-L-G-I-S-G-P-G-M-T-R-M-E-A-L-E-R-V-H-Y-A-K-R-A-V-E-A-A-V-K-M-V-R-R-L-R-E-L-E-G-E


### FUNCTION Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA ### SEQUENCE -M-I-V-V-S-K-V-L-V-D-L-K-V-L-P-E-S-A-D-V-D-Y-E-E-L-K-E-A-I-R-E-K-L-E-S-M-D-V-V-D-I-E-G-M-E-E-E-P-I-A-F-G-L-K-A-I-R-V-K-V-V-V-P-D-A-E-G-G-T-D-A-L-E-D-A-L-K-E-V-D-E-V-N-Q-V-E-V-V-S-A-S-R-T-L


### FUNCTION Involved in the binding of tRNA to the ribosomes ### SEQUENCE -M-A-Q-E-V-R-L-R-L-S-S-T-D-H-Y-K-L-E-E-V-C-E-R-I-K-K-V-V-E-E-T-G-A-Q-M-S-G-P-I-P-L-P-T-K-R-L-L-V-P-T-R-K-S-P-D-G-E-G-K-A-T-W-D-K-W-E-M-R-I-H-K-R-L-I-D-I-K-G-D-E-R-T-I-R-R-L-M-R-I-H-I-P-E-E-V-H-V-E-I-I-M-K


### FUNCTION Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently ### SEQUENCE -M-P-W-E-E-I-E-H-T-A-D-A-A-F-R-V-W-A-D-T-P-E-D-L-L-V-E-A-A-K-A-L-F-D-L-I-T-D-L-D-A-V-E-P-E-E-E-V-E-I-E-A-E-G-G-D-L-V-E-L-L-H-D-W-L-E-E-I-H-F-R-H-E-I-D-G-M-L-F-S-D-F-E-V-K-E-L-K-K-E-E-G-W-K-V-R-G-V-A-R-G-E-P-Y-D-P-D-R-H-P-F-H-T-E-V-K-A-V-T-Y-H-N-M-K-V-E-R-E-D-G-R-W-V-A-E-Y-V-V-D-L


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-A-K-G-T-P-S-F-G-K-R-N-K-T-K-T-H-V-R-C-R-R-C-G-R-R-A-Y-H-V-R-K-G-Y-C-A-A-C-G-F-G-R-S-R-R-I-R-R-Y-S-W-Q-N-K-K-V-N-R-K-R-R-R


### FUNCTION Involved in protein export The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex ### SEQUENCE -M-G-K-K-M-E-K-K-R-A-E-M-P-P-A-R-A-G-I-L-S-F-W-D-E-E-A-P-G-I-K-I-D-P-D-Y-I-L-Y-A-C-F-A-V-A-V-L-L-I-I-A-H-T-M-A-A-V


### FUNCTION Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP ### SEQUENCE -M-Y-V-G-R-F-L-L-A-G-K-L-E-D-G-T-P-I-A-V-Y-G-V-C-S-R-S-F-S-D-R-R-I-E-V-R-E-G-A-A-F-V-V-P-E-D-P-S-Y-I-T-E-N-P-Y-V-T-Y-T-C-A-R-I-V-D-E-F-L-V-L-T-N-G-A-Q-T-D-P-I-A-D-K-L-E-S-G-V-P-P-R-E-A-L-V-S-V-T-F-A-M-D-Y-E-H-D-E-Y-N-T-P-R-I-S-L-I-T-D-G-E-T-F-W-L-G-R-V-A-P-E-E-V-Y-F-R-V-M-K-P-K-D-G-E-G-Y-L-L-S-V-Y-G-E-Y-A-E-V-P-S-K-P-N-M-T-L-D-R-E-D-P-L-E-C-D-P-V-P-S-F-E-H-Y-V-C-S-V-I-A-R-H-D-G-G-R-W-S-L-E-A-R


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-V-V-R-R-K-K-K-S-P-K-K-Y-R-G-S-R-T-H-G-G-G-S-H-K-N-R-R-G-A-G-N-R-G-G-R-G-M-A-G-S-H-K-H-K-W-F-H-V-I-K-Y-M-P-D-H-F-G-K-R-G-F-N-R-P-P-K-V-V-R-E-P-N-T-I-N-V-G-E-L-D-A-L-A-D-K-L-L-E-D-G-I-A-E-K-D-G-D-K-I-V-I-D-V-T-D-E-R-L-K-P-Y-G-G-P-F-D-K-V-L-G-G-G-H-V-K-R-P-L-V-V-V-A-P-E-F-T-E-R-A-V-E-K-L-E-E-A-G-G-E-A-R-E-A


### FUNCTION Involved in protein export The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex ### SEQUENCE -M-A-K-E-K-T-T-L-P-P-T-G-A-G-L-M-R-F-F-D-E-D-T-K-A-V-K-V-T-P-K-G-A-L-A-I-V-L-V-F-I-L-I-E-V-L-L-Q-I-I-G-P-R-I-F-G


### FUNCTION Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors ### SEQUENCE -M-P-K-Q-V-V-E-V-L-V-E-G-G-K-A-T-P-G-P-P-L-G-P-A-I-G-P-L-G-L-N-V-K-Q-V-V-D-K-I-N-E-A-T-K-D-F-A-G-M-Q-V-P-V-K-I-I-V-D-P-V-T-K-Q-F-E-I-E-V-G-V-P-P-T-S-Q-L-I-K-K-E-L-G-L-E-K-G-S-G-E-P-K-H-N-I-V-G-N-L-T-M-E-Q-V-I-K-I-A-K-M-K-K-D-Q-M-L-A-L-T-L-K-A-A-A-K-E-V-I-G-T-A-L-S-M-G-V-T-V-E-G-K-D-P-R-E-V-Q-K-E-I-D-E-G-V-Y-D-E-L-F-E-K-A-E-K-E


### FUNCTION Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA ### SEQUENCE -M-G-D-F-N-L-V-G-V-I-R-V-M-P-T-D-P-E-V-N-L-D-E-L-E-E-K-L-K-A-L-I-P-E-K-Y-G-L-A-K-V-E-R-E-P-I-A-F-G-L-V-A-L-K-F-Y-V-L-G-R-D-E-E-G-Y-S-F-D-E-I-A-E-K-F-Q-E-V-E-E-V-E-S-A-E-V-E-T-V-S-R-I


### FUNCTION Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP ### SEQUENCE -M-G-R-F-V-V-W-P-S-E-L-D-S-R-L-S-R-K-Y-G-R-I-V-P-R-S-I-A-V-E-S-P-R-V-E-E-I-V-R-A-A-E-E-L-K-F-K-V-I-R-V-E-E-D-K-L-N-P-R-L-S-G-I-D-E-E-L-R-T-F-G-M-I-V-L-E-S-P-Y-G-K-S-K-S-L-K-L-I-A-Q-K-I-R-E-F-R-R-R-S-A


### FUNCTION Binds double-stranded DNA tightly but without sequence specificity It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture However, it does not significantly compact DNA Binds rRNA and mRNA in vivo May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes ### SEQUENCE -M-A-E-E-H-V-V-Y-I-G-K-K-P-V-M-N-Y-V-L-A-V-I-T-Q-F-N-E-G-A-K-E-V-S-I-K-A-R-G-R-A-I-S-R-A-V-D-V-A-E-I-V-R-N-R-F-L-K-D-T-V-D-I-K-E-I-K-I-G-T-E-E-L-P-T-A-D-G-R-T-T-N-T-S-T-I-E-I-V-L-E-R-K-V


### FUNCTION Probable zinc metalloprotease whose natural substrate is unknown ### SEQUENCE -M-R-D-M-I-I-V-V-P-I-G-E-V-P-S-D-V-L-S-F-L-S-E-N-I-E-S-F-Y-M-K-F-G-I-G-V-K-I-I-G-S-L-P-I-S-A-F-S-H-A-Y-D-F-Y-R-N-Q-Y-L-A-R-H-F-L-P-A-L-S-I-I-R-R-D-Y-K-A-L-A-V-M-G-V-T-E-V-D-L-Y-E-S-G-L-N-F-I-F-G-I-A-H-P-G-F-G-V-A-L-I-S-L-H-R-L-Y-P-E-F-Y-G-E-P-P-D-R-K-L-L-K-E-R-A-L-K-E-A-M-H-E-L-G-H-V-F-G-L-E-H-C-P-N-P-K-C-V-M-H-F-S-N-S-I-I-D-T-D-I-K-S-W-M-Y-C-K-N-C-L-R-K-L-E-E-R-L-G-R-G-Y-V-R-G-R-T


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-A-R-K-E-F-R-Y-R-G-Y-T-L-E-Q-L-M-N-M-S-L-E-E-L-A-R-L-F-P-A-R-Q-R-R-S-L-K-R-G-L-T-P-E-Q-K-K-L-L-R-K-I-R-L-A-K-K-G-K-Y-K-K-P-I-R-T-H-C-R-D-M-I-I-L-P-E-M-V-G-L-T-I-Y-V-H-N-G-K-E-F-V-P-V-E-I-K-P-E-M-I-G-H-Y-L-G-E-F-A-P-T-R-K-K-V-E-H-G-A-P-G-V-G-A-T-R-S-S-M-F-V-A-V-K


### FUNCTION This protein binds specifically to 23S rRNA It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome ### SEQUENCE -M-A-K-R-F-G-Y-S-F-Q-N-F-D-P-K-R-M-A-R-A-S-A-R-D-L-R-I-S-P-K-L-A-V-E-V-C-R-E-L-R-G-M-M-L-N-D-A-L-R-Y-L-D-D-V-I-A-L-K-R-P-V-P-L-K-R-Y-N-D-S-Q-G-H-K-P-G-K-G-F-G-P-G-R-Y-P-V-K-V-A-K-A-I-K-K-V-L-L-N-V-K-N-N-A-V-Q-K-G-L-D-P-D-K-L-K-I-I-H-I-A-A-H-K-G-P-V-L-R-G-W-Y-P-R-A-F-G-R-A-T-P-F-N-E-Q-T-T-H-I-E-V-V-V-E-E-I-R-R


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-M-R-D-I-G-L-R-V-Q-P-P-A-E-K-C-D-D-P-K-C-P-W-H-G-N-L-K-I-H-G-R-V-F-E-G-I-V-V-S-D-K-P-R-K-T-V-T-V-E-R-Q-Y-Y-F-Y-L-N-K-Y-E-R-Y-E-L-R-R-S-K-I-H-A-H-N-P-P-C-I-N-A-K-V-G-D-K-V-L-I-A-E-T-R-P-L-S-K-T-K-H-F-V-V-V-A-V-L-E-R-A-E-E-R-R


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-A-K-K-G-A-G-A-T-R-G-V-S-A-V-R-P-T-R-A-L-P-V-G-A-Y-L-T-V-A-D-N-S-G-A-K-V-I-Q-I-I-G-V-V-E-Y-H-G-T-R-R-R-L-A-S-A-G-V-G-D-M-V-V-A-T-V-K-K-G-R-P-D-M-R-H-Q-V-V-R-A-V-I-I-R-Q-R-K-E-Y-R-R-L-D-G-M-R-V-K-F-E-D-N-A-A-V-I-V-T-P-E-G-V-P-R-G-T-E-I-R-G-P-V-A-R-E-A-A-E-R-W-V-R-I-G-S-I-A-S-I-I-V


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-T-L-L-D-P-L-A-N-A-L-S-H-I-T-N-S-E-R-V-G-K-R-E-V-Y-I-K-P-A-S-K-L-I-G-E-V-L-R-V-M-Q-K-Y-G-Y-I-G-E-F-E-F-I-D-D-G-R-A-G-V-Y-R-V-Q-L-L-G-R-I-N-K-A-G-A-I-K-P-R-F-P-V-K-V-S-E-F-E-K-W-E-K-R-F-L-P-A-F-E-F-G-I-L-I-V-S-T-S-Q-G-V-M-S-H-K-E-A-I-E-K-G-I-G-G-R-L-I-A-Y-V-Y


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-P-V-D-A-W-I-R-E-E-V-E-I-P-E-G-V-E-V-T-V-E-G-Y-K-V-K-V-K-G-P-K-G-E-L-E-R-E-F-F-W-P-G-I-Q-I-F-T-E-D-G-N-V-V-I-Y-K-D-F-P-R-R-K-D-V-A-I-A-R-T-F-A-A-H-I-R-N-M-I-K-G-V-T-E-G-F-T-Y-K-L-K-V-V-Y-S-H-F-P-I-S-V-K-V-Q-G-D-E-V-I-I-E-N-F-L-G-E-K-A-P-R-K-A-K-I-L-P-G-V-T-V-K-V-R-G-Q-E-I-I-V-E-G-I-D-K-E-A-V-G-Q-T-A-A-N-I-E-Q-A-T-R-I-T-K-W-D-R-R-I-F-Q-D-G-I-Y-I-V-E-K-A-G-K-P-I-T-F


### FUNCTION Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate ### SEQUENCE -M-I-T-R-G-R-V-W-K-F-G-D-N-I-S-T-D-A-I-T-P-G-R-Y-N-L-T-K-D-P-N-E-L-A-K-I-A-F-I-E-E-R-P-E-F-S-K-E-V-K-P-G-D-V-V-V-G-G-K-N-F-G-I-G-S-S-R-E-S-A-A-L-A-L-K-A-A-G-V-G-G-V-I-A-K-S-F-G-R-I-F-F-R-N-A-V-N-L-G-L-P-L-L-I-G-N-T-D-P-L-L-D-G-E-I-V-E-V-N-W-R-S-G-E-V-K-K-E-D-G-E-V-L-K-F-K-P-L-D-S-F-L-L-A-I-V-E-E-G-G-I-I-E-Y-I-R-R-R-G-D-L-W-I-Q


### FUNCTION Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA In the 70S ribosome it contacts the 23S rRNA , connecting the 2 subunits ### SEQUENCE -M-A-N-F-R-H-I-V-R-V-A-G-V-D-L-D-G-N-K-Q-L-R-W-A-L-T-A-I-K-G-I-G-I-N-F-A-T-M-V-C-R-V-A-G-L-D-P-F-M-K-A-G-Y-L-T-D-E-Q-V-K-K-I-E-E-I-L-A-D-P-V-A-H-G-I-P-R-W-A-V-N-R-P-K-D-Y-E-T-G-R-D-L-H-L-I-T-A-K-L-D-M-A-I-R-E-D-I-M-R-L-R-R-I-R-A-Y-R-G-I-R-H-E-L-G-L-P-V-R-G-Q-R-T-R-S-N-F-R-R-G-Q-T-V-G-V-S-R-K-K-K


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-R-I-I-N-A-E-G-L-I-L-G-R-L-A-S-K-V-A-K-M-L-L-E-G-E-E-V-V-I-V-N-A-E-K-A-V-I-T-G-N-R-D-V-I-F-K-K-Y-K-Q-R-T-E-L-R-T-L-T-N-P-R-R-G-P-F-Y-P-K-R-S-D-E-I-V-R-R-T-I-R-G-M-L-P-W-K-T-D-R-G-R-K-A-F-K-R-L-K-V-Y-V-G-I-P-K-E-F-Q-G-K-E-L-E-T-I-I-E-A-H-V-S-R-L-S-R-P-K-Y-V-T-V-G-E-V-A-K-F-L-G-G-K-F


### FUNCTION Seems to be required for maximal rate of protein biosynthesis Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA to 40 S ribosomal subunits ### SEQUENCE -M-L-M-P-K-K-E-R-K-V-E-G-E-E-V-I-R-V-P-L-P-E-G-N-Q-L-F-G-V-V-E-Q-A-L-G-A-G-W-M-D-V-R-C-E-D-G-K-V-R-R-C-R-I-P-G-R-L-R-R-R-V-W-I-K-V-G-D-L-V-I-V-E-P-W-P-V-Q-S-D-K-R-G-D-I-V-Y-R-Y-T-Q-T-Q-V-E-W-L-L-R-K-G-K-I-S-Q-E-F-L-T-G-G-S-L-L-L-E


### FUNCTION The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis ### SEQUENCE -M-G-F-R-Y-K-Q-V-I-V-A-R-S-D-L-K-L-S-K-G-K-L-A-V-Q-V-A-H-G-A-V-T-A-A-F-E-A-Y-K-K-K-R-E-W-F-E-A-W-F-R-E-G-Q-K-K-V-V-V-K-A-Q-N-E-E-E-L-F-K-L-K-S-E-A-E-K-L-G-L-P-T-A-L-I-R-D-A-G-L-T-E-I-P-P-G-T-I-T-V-L-A-I-G-P-G-P-E-E-V-V-D-K-V-T-G-H-L-K-L-L


### FUNCTION Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently ### SEQUENCE -M-R-Q-W-E-H-Y-E-H-T-A-D-I-G-I-R-G-Y-G-D-T-L-E-E-A-F-E-A-V-A-L-A-L-F-D-V-I-V-N-V-R-K-I-E-K-K-V-E-I-D-I-E-V-E-G-E-D-L-E-S-L-L-Y-S-F-L-E-E-L-L-Y-L-H-D-I-E-G-L-V-F-G-D-F-K-V-K-I-E-Q-K-D-G-K-Y-I-L-R-G-K-A-Y-G-E-K-F-D-P-E-K-H-E-P-K-E-E-V-K-A-I-T-Y-H-D-M-K-I-E-R-L-P-D-G-R-W-M-A-Q-L-V-P-D-I


### FUNCTION Contacts the emerging nascent chain on the ribosome ### SEQUENCE -M-M-P-M-N-P-K-Q-L-K-K-L-M-K-Q-L-D-M-R-Q-L-D-N-V-V-E-V-I-I-R-L-E-D-R-E-I-I-I-K-N-P-T-V-T-V-I-K-A-M-G-E-K-I-Y-Q-I-A-G-G-E-E-E-E-K-V-K-L-V-I-S-E-E-D-I-K-L-V-M-E-Q-T-G-V-D-Y-E-T-A-K-K-A-L-E-E-A-N-G-D-L-A-E-A-I-L-K-L-T-E-G-S-P


### FUNCTION DNA-binding protein involved in the repression of transcription of a large number of genes, thereby arresting growth, in response to environmental changes ### SEQUENCE -M-R-G-I-L-D-D-I-D-K-K-I-I-E-I-L-Q-K-D-G-K-V-P-L-R-E-I-S-K-I-T-G-L-A-E-S-T-I-H-E-R-I-K-R-L-R-E-S-G-V-I-K-K-F-T-A-V-V-N-P-E-A-L-G-Y-N-I-L-A-F-I-L-I-K-V-K-A-G-K-Y-S-E-V-A-S-K-L-V-K-Y-P-E-I-V-E-V-Y-E-T-T-G-D-Y-D-M-V-V-K-I-R-T-K-N-S-E-E-L-N-N-F-L-D-M-V-G-S-I-E-G-V-E-G-T-H-T-M-I-V-L-K-V-H-K-E-T-T-E-L-P-V-K


### FUNCTION Catalyzes the synthesis of GMP from XMP ### SEQUENCE -M-I-I-I-M-D-N-G-G-Q-Y-V-H-R-I-W-R-T-L-R-Y-L-G-V-E-A-K-I-I-P-N-T-T-P-L-D-E-I-K-A-M-K-P-K-G-I-I-F-S-G-G-P-S-L-E-N-T-G-N-C-E-K-I-L-E-H-Y-E-E-F-N-V-P-I-L-G-I-C-L-G-H-Q-L-I-A-K-F-F-G-G-E-V-G-R-G-E-K-A-E-Y-S-L-V-E-I-E-I-I-D-E-N-D-I-F-K-G-L-P-R-K-V-R-V-W-E-S-H-M-D-E-V-K-K-L-P-P-K-F-K-L-L-A-R-S-D-T-C-P-V-E-A-M-K-H-E-E-L-P-I-Y-G-V-Q-F-H-P-E-V-A-H-T-E-H-G-A-D-I-L-R-N-F-A-K-I-C-G-E-L


### FUNCTION The glycine cleavage system catalyzes the degradation of glycine The H protein shuttles the methylamine group of glycine from the P protein to the T protein ### SEQUENCE -M-I-E-V-G-E-Y-K-I-K-E-G-L-Y-Y-T-K-E-H-E-W-V-Q-V-L-E-D-G-T-V-L-V-G-I-T-D-Y-A-Q-K-E-L-G-D-L-A-Y-V-E-L-P-E-V-G-K-V-V-E-K-G-D-V-L-C-E-V-E-S-V-K-A-V-S-E-V-Y-A-P-V-S-G-E-V-I-E-V-N-E-E-L-A-D-S-P-E-K-I-N-E-D-P-Y-E-A-W-I-A-K-I-K-P-K-N-L-E-E-E-L-K-E-L-M-D-A-K-A-Y-A-E-Y-L-K-T-L


### FUNCTION Functions by promoting the formation of the first peptide bond ### SEQUENCE -M-G-D-K-T-K-V-Q-V-S-K-L-K-P-G-R-Y-I-I-I-D-D-E-P-C-R-I-V-N-I-T-V-S-S-P-G-K-H-G-S-A-K-A-R-I-E-A-V-G-I-F-D-G-K-V-R-S-I-V-K-P-T-S-A-E-V-D-V-P-I-I-D-K-R-T-A-Q-V-I-A-V-T-P-D-T-V-Q-I-M-D-M-E-T-Y-E-M-F-E-V-P-L-D-T-G-V-E-E-E-I-K-D-K-I-K-E-G-I-N-V-E-Y-W-E-T-L-G-R-I-K-I-M-R-I-K-G-E-E-E