### FUNCTION Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors ### SEQUENCE -M-A-E-F-N-R-E-A-Y-S-E-R-E-R-S-A-A-S-M-K-T-L-L-R-K-Q-E-L-V-N-S-Y-K-E-R-L-Q-R-S-N-G-F-V-V-F-F-N-F-Q-G-I-D-A-Y-P-L-T-L-L-R-L-D-I-K-D-L-K-G-E-I-V-V-G-K-N-T-L-F-Y-R-A-F-S-D-T-A-L-S-D-H-R-D-I-F-I-G-P-T-A-A-L-F-A-Y-E-D-P-V-A-V-T-K-K-L-V-E-F-L-K-E-T-F-D-K-E-W-E-G-R-I-K-G-G-L-L-D-Y-K-Y-I-S-P-E-Q-V-K-E-L-A-E-L-P-S-K-E-E-L-I-A-K-L-L-G-V-M-M-A-P-V-T-Q-L-A-M-T-L-K-A-V-P-Q-K-L-V-L-V-L-K-A-I-E-E-E-K-S-K-G-G-Q


### FUNCTION Binds directly to 23S rRNA The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release ### SEQUENCE -I-L-G-P-R-G-L-M-P-S-P-K-T-G-T-V-T-K-N-V-E-Q-A-I-K-D-A-K-R-G-R-V-E-F-K-V-D-K-A-G-N-I-H-M-P-V-G-K-V-S-F-D-K-A-K-L-L-D-N-I-Y-A-A-I-D-A-V-V-R-A-K-P-P-G-A-K-G-Q-Y-V-K-N-I-A-L-S-L-T-M-S-P-S-V-K-I-D-I-N-E-T-L-R-K-L-Q-E-R-A-A


### FUNCTION Binds to actin and affects the structure of the cytoskeleton At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations By binding to PIP2, it inhibits the formation of IP3 and DG ### SEQUENCE -M-S-W-Q-A-Y-V-D-D-H-L-M-C-E-V-E-G-N-P-G-Q-T-L-T-A-A-A-I-I-G-H-D-G-S-V-W-A-Q-S-S-T-F-P-Q-I-K-P-E-E-I-A-G-I-M-K-D-F-D-E-P-G-H-L-A-P-T-G-L-Y-L-G-G-A-K-Y-M-V-I-Q-G-E-P-N-A-V-I-R-G-K-K-G-S-G-G-V-T-I-K-K-T-G-Q-A-L-V-F-G-V-Y-D-E-P-V-T-P-G-Q-C-N-V-I-V-E-R-L-G-D-Y-L-I-D-Q-G-L


### FUNCTION Binds to actin and affects the structure of the cytoskeleton At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations By binding to PIP2, it inhibits the formation of IP3 and DG ### SEQUENCE -M-S-W-Q-A-Y-V-D-D-H-L-M-C-D-I-D-G-H-H-L-T-A-A-A-I-L-G-H-D-G-S-V-W-A-Q-S-S-T-F-P-K-F-K-P-E-E-I-T-A-I-M-K-D-F-D-E-P-G-S-L-A-P-T-G-L-H-L-G-G-T-K-Y-M-V-I-Q-G-E-G-G-A-V-I-R-G-K-K-G-S-G-G-V-T-V-K-K-T-S-Q-A-L-V-F-G-I-Y-E-E-P-L-T-P-G-Q-C-N-M-I-V-E-R-L-G-D-Y-L-I-D-Q-G-L


### FUNCTION Binds to actin and affects the structure of the cytoskeleton At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations By binding to PIP2, it inhibits the formation of IP3 and DG ### SEQUENCE -M-S-W-Q-A-Y-V-D-D-H-L-M-C-D-I-D-G-N-R-L-T-A-A-A-I-L-G-Q-D-G-S-V-W-S-Q-S-A-T-F-P-A-F-K-P-E-E-I-A-A-I-L-K-D-L-D-Q-P-G-T-L-A-P-T-G-L-F-L-G-G-T-K-Y-M-V-I-Q-G-E-A-G-A-V-I-R-G-K-K-G-S-G-G-I-T-V-K-K-T-N-Q-A-L-I-I-G-I-Y-D-E-P-L-T-P-G-Q-C-N-M-I-V-E-R-L-G-D-Y-L-I-E-Q-G-L


### FUNCTION RuBisCO catalyzes two reactions the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Both reactions occur simultaneously and in competition at the same active site Although the small subunit is not catalytic it is essential for maximal activity ### SEQUENCE -M-A-S-S-L-M-S-N-A-I-T-A-V-V-G-A-S-G-A-Q-A-N-M-V-A-P-F-N-G-L-K-S-I-A-S-F-P-V-T-R-K-S-N-D-I-T-S-I-A-S-N-G-G-R-V-Q-C-M-Q-V-W-P-P-V-G-K-K-K-F-E-T-L-S-Y-L-P-P-L-S-D-A-Q-L-L-A-Q-V-Q-Y-L-L-N-N-G-W-I-P-C-I-E-F-E-L-E-H-P-F-V-Y-R-E-N-H-R-S-P-G-Y-Q-D-G-R-Y-W-T-M-W-K-L-P-M-Y-G-C-T-D-P-A-Q-V-L-N-E-V-E-E-A-K-K-A-Y-P-S-A-F-I-R-I-I-G-F-D-N-K-R-Q-V-Q-C-V-S-F-I-A-F-K-P-P-G-Y


### FUNCTION RuBisCO catalyzes two reactions the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Both reactions occur simultaneously and in competition at the same active site Although the small subunit is not catalytic it is essential for maximal activity ### SEQUENCE -M-A-S-S-M-M-S-N-A-A-T-A-V-A-V-A-A-T-S-G-G-A-Q-A-N-M-V-A-P-F-N-G-L-K-S-I-A-S-F-P-V-T-R-K-S-N-D-I-T-S-I-A-S-N-G-G-R-V-Q-C-M-Q-V-W-P-P-V-G-K-K-K-F-E-T-L-S-Y-L-P-P-L-S-D-A-Q-L-L-A-Q-V-Q-Y-L-L-N-K-G-W-I-P-C-I-E-F-E-L-E-H-P-F-V-Y-R-E-N-H-R-S-P-G-Y-Q-D-G-R-Y-W-T-M-W-K-L-P-M-Y-G-C-T-D-P-A-Q-V-L-N-E-V-E-E-A-K-K-A-Y-P-T-A-F-I-R-I-I-G-F-D-N-K-R-Q-V-Q-C-V-S-F-I-A-Y-K-P-A-D-S-Y


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-D-K-S-M-L-G-D-L-D-G-L-P-E-E-D-K-M-R-M-A-A-M-V-D-Q-L-Q-I-R-D-S-L-R-M-Y-N-S-L-V-E-R-C-F-T-D-C-V-D-T-F-R-R-K-T-L-D-K-Q-E-E-S-C-V-R-R-C-A-E-K-F-L-K-H-S-M-R-V-G-M-R-F-A-E-L-N-Q-G-V-A-T-P-D


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-D-K-N-M-L-G-D-L-D-N-L-P-E-E-D-K-L-K-M-A-S-M-I-E-Q-L-Q-I-R-D-S-L-R-M-Y-N-N-L-V-E-R-C-F-T-D-C-V-D-S-F-R-R-K-T-L-D-K-Q-E-E-T-C-V-K-R-C-A-E-K-F-L-K-H-S-M-R-V-G-L-R-F-A-E-L-N-Q-G-A-A-T-T-D


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-D-S-F-S-S-S-S-G-S-P-P-N-T-E-A-L-M-D-Q-I-K-A-Q-L-A-Q-A-Y-A-Q-E-F-L-E-T-V-G-N-K-C-F-A-K-C-V-T-K-P-G-S-S-L-S-G-S-E-S-S-C-I-S-R-C-V-D-R-Y-I-E-A-T-G-I-V-S-R-A-L-F-S-S-T-R


### FUNCTION Cytokinin-activating enzyme working in the direct activation pathway Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms ### SEQUENCE -M-H-I-E-H-I-S-G-E-T-V-G-E-V-R-I-V-S-D-M-H-E-R-K-A-T-M-A-Q-E-A-G-A-F-I-A-L-L-G-E-R-Y-E-T-M-E-E-L-L-E-M-I-T-W-A-Q-L-G-I-H-K-K-T-V-G-L-L-N-V-D-G-Y-Y-N-N-L-L-A-F-F-D-T-G-V-E-E-G-F-I-K-Q-G-A-C-N-I-V-V-S-A-P-S-A-R-E-L-M-E-K-M-E-L-Y-T-P-S-H-K-Y-I-A-S-H-Q-S-W-K-V-E-P-L-G-D-Y-P-L-L-N-E-N-K-P-Q


### FUNCTION May form complexes with phosphorylated ligands by interfering with kinases and their effectors ### SEQUENCE -M-G-S-K-M-S-D-P-L-V-I-G-R-V-I-G-E-V-V-D-Y-F-T-P-S-V-K-M-S-V-T-Y-N-S-S-K-H-V-Y-N-G-H-E-L-F-P-S-S-V-T-S-K-P-R-V-E-V-H-G-G-D-L-R-S-F-F-T-L-I-M-I-D-P-D-V-P-G-P-S-D-P-Y-L-R-E-H-L-H-W-I-V-T-D-I-P-G-T-T-D-C-S-F-G-R-E-I-V-G-Y-E-M-P-R-P-N-I-G-I-H-R-F-V-F-L-L-F-K-Q-K-K-R-Q-T-L-L-S-A-P-L-S-R-D-R-F-N-T-R-K-F-S-E-E-N-E-L-G-S-P-V-A-A-A-F-F-N-C-Q-R-E-T-A-A-R-R-R


### FUNCTION May form complexes with phosphorylated ligands by interfering with kinases and their effectors ### SEQUENCE -M-G-S-K-M-S-D-P-L-V-I-G-R-V-I-G-E-V-V-D-Y-F-T-P-S-V-K-M-S-V-T-Y-N-S-S-K-H-V-Y-N-G-H-E-L-F-P-S-S-V-T-S-K-P-R-V-E-V-H-G-G-D-L-R-S-F-F-T-M-I-M-I-D-P-D-V-P-G-P-S-D-P-Y-L-R-E-H-L-H-W-I-V-T-D-I-P-G-T-T-D-C-S-F-G-K-E-I-V-G-Y-E-M-P-R-P-N-I-G-I-H-R-F-V-F-L-L-F-K-Q-K-K-R-Q-T-V-L-T-A-P-L-S-R-D-R-F-N-T-R-K-F-A-E-E-N-E-L-G-S-P-V-A-A-V-F-F-N-C-Q-R-E-T-A-A-R-R-R


### FUNCTION May form complexes with phosphorylated ligands by interfering with kinases and their effectors ### SEQUENCE -M-A-S-R-V-V-E-P-L-V-V-A-R-V-I-G-E-V-V-D-S-F-N-P-S-V-K-L-N-V-I-Y-N-G-S-K-Q-V-F-N-G-H-E-L-M-P-A-V-I-A-A-K-P-R-V-E-I-G-G-E-D-M-R-S-A-Y-T-L-I-M-T-D-P-D-V-P-G-P-S-D-P-Y-L-R-E-H-L-H-W-I-V-T-D-I-P-G-S-T-D-S-S-F-G-R-E-I-V-S-Y-E-S-P-K-P-V-I-G-I-H-R-Y-V-L-L-L-Y-K-Q-S-G-R-Q-T-V-K-P-A-A-T-R-D-H-F-N-T-R-R-Y-T-A-E-N-G-L-G-S-P-V-A-A-V-Y-F-N-A-Q-R-E-T-A-A-R-R-R


### FUNCTION Involved in calcium binding and microtubule stabilization ### SEQUENCE -M-L-V-Y-Q-D-L-L-S-G-D-E-L-P-S-D-S-F-S-Y-T-E-L-G-N-G-V-L-W-E-V-Q-G-K-W-V-V-Q-G-A-V-D-V-N-I-G-A-N-P-S-A-E-G-A-D-E-D-E-G-V-D-D-Q-A-I-K-V-V-D-I-V-D-T-F-R-L-Q-E-Q-P-S-F-D-K-K-Q-F-V-A-Y-M-K-K-Y-I-K-N-L-T-P-K-L-G-A-E-Q-E-E-V-F-K-N-N-I-Q-G-A-T-K-Y-L-L-S-K-L-S-D-L-Q-F-F-V-G-E-S-M-A-D-D-T-G-M-V-F-A-Y-Y-K-D-G-A-T-D-P-T-F-L-Y-L-A-H-G-L-K-E-V-K-C


### FUNCTION Facilitates protein transport into the nucleus Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import ### SEQUENCE -M-D-A-D-A-V-A-K-A-F-V-E-H-Y-Y-R-T-F-D-T-N-R-P-A-L-V-S-L-Y-Q-D-G-S-M-L-T-F-E-G-Q-Q-F-L-G-A-A-A-I-A-G-K-L-G-S-L-P-F-A-Q-C-H-H-D-I-N-T-V-D-C-Q-P-S-G-P-Q-G-G-M-L-V-F-V-S-G-S-L-R-T-G-P-D-E-H-P-L-K-F-S-Q-M-F-Q-L-L-P-A-G-G-N-F-Y-V-Q-N-D-M-F-R-L-N-Y-G


### FUNCTION This protein is essential for replication of the chromosomes and its single-stranded DNA phages It is also involved in DNA recombination and repair ### SEQUENCE -M-A-Q-R-G-V-N-K-V-I-L-I-G-T-L-G-Q-D-P-E-I-R-Y-I-P-N-G-G-A-V-G-R-L-S-I-A-T-N-E-S-W-R-D-K-Q-T-G-Q-Q-K-E-Q-T-E-W-H-K-V-V-L-F-G-K-L-A-E-I-A-S-E-Y-L-R-K-G-S-Q-V-Y-I-E-G-K-L-K-T-R-K-W-T-D-D-A-G-V-E-R-Y-T-T-E-I-I-V-S-Q-G-G-T-M-Q-M-I-G-A-R-R-D-D-S-Q-S-S-N-G-W-G-Q-S-N-Q-P-Q-N-H-Q-Q-Y-S-G-G-G-K-P-Q-S-N-A-N-N-E-P-P-M-D-F-D-D-D-I-P-F


### FUNCTION Component of the spanin complex that disrupts the host outer membrane and causes cell lysis during virus exit The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans ### SEQUENCE -M-R-E-L-K-M-K-L-C-V-L-M-L-P-L-V-V-S-A-C-G-S-T-P-P-A-P-V-P-C-V-K-P-P-A-P-P-A-W-I-M-Q-P-A-P-D-W-Q-T-P-L-N-G-I-I-S-S-S-E-R-G


### FUNCTION Exolysin that catalyzes the cleavage of the host peptidoglycans during virus entry ### SEQUENCE -M-I-N-K-T-T-I-K-T-V-L-I-T-L-G-V-L-A-A-V-N-K-V-S-A-L-R-S-V-K-R-L-I-S


### FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase ### SEQUENCE -M-N-L-I-D-L-I-L-I-A-I-Y-V-I-G-I-S-G-L-I-F-N-K-N-N-I-I-N-I-L-I-I-S-E-L-N-L-G-T-L-G-M-L-F-V-L-A-S-V-E-L-N-D-I-L-G-E-L-S-G-L-Y-I-L-T-F-T-A-A-E-S-A-I-G-L-A-I-V-V-I-L-Y-S-K-T-G-I-I-N-I-R-H-L-N-K-L-K-G


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation This subunit is found at the monomer-monomer interface ### SEQUENCE -M-E-V-N-I-L-A-F-I-A-T-A-L-F-I-L-V-P-T-S-F-L-L-I-I-Y-V-K-T-V-S-Q-N-N


### FUNCTION Binds to 23S rRNA ### SEQUENCE -M-T-Q-L-N-S-F-F-Y-V-S-D-N-T-G-V-K-K-I-F-S-I-Q-N-I-T-R-N-S-F-L-V-N-T-T-D-I-I-L-G-I-I-K-E-I-S-F-K-S-S-F-K-Y-S-E-I-V-Y-G-F-V-V-R-L-K-K-T-Q-N-I-Q-N-R-Y-N-Y-I-F-N-E-N-A-V-I-L-I-D-K-N-F-N-P-L-G-T-R-I-F-G-L-F-P-E-N-L-K-N-N-N-Y-L-K-L-N-S-L-V-L-N-I-I


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit ### SEQUENCE -M-K-K-K-F-R-T-K-L-K-K-L-Q-Y-F-K-L-T-F-L-P-G-F-C-T-K-L-L-K-K-E-L-V-P-I-K-K-G-K-T-S-S-F-R-I-Q-L-L-E-K-Q-K-L-K-Y-N-Y-R-L-K-E-N-Q-I-K-K-Y-F-K-Y-I-K-L-L-K-I-F-N-L-I-Q-I-I-E-L-R-L-D-A-T-I-F-R-L-G-F-A-K-S-I-N-Q-A-R-Q-L-I-T-H-G-F-I-F-I-N-S-I-L-V-K-K-P-S-F-I-L-T-E-K-D-L-I-Y-I-N-P-K-K-F-T-I-I-L-I-C-R-I-N-L-F-F-R-Y-Y-N-K-Y-N-L-Y-I-Y-T-L-C-V-E-Y-L-K-F-K-L-Q-K-E-F-Y-F-K-L-Y-L-F-I-P-F-D-E-N-L-I-K-Y-Y-Y-K-F


### FUNCTION May play a role in photosystem I and II biogenesis ### SEQUENCE -M-E-T-A-T-L-I-A-I-S-I-S-G-L-I-V-S-F-T-G-Y-A-L-Y-T-A-F-G-Q-P-S-Q-Q-L-R-D-P-F-E-E-H-G-D


### FUNCTION Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells ### SEQUENCE -M-Y-R-M-Q-L-L-S-C-I-A-L-S-L-A-L-I-T-N-S-A-P-T-S-S-S-T-K-K-T-Q-L-Q-L-E-H-L-L-L-D-L-Q-M-L-L-N-G-I-N-N-Y-K-N-P-K-L-T-R-M-L-T-F-K-F-Y-M-P-K-K-A-T-E-L-K-H-L-Q-C-L-E-E-E-L-K-P-L-E-E-V-L-N-L-A-Q-S-K-N-F-H-L-R-D-T-R-D-I-I-S-N-I-N-V-L-V-L-E-L-K-G-S-E-T-T-F-T-C-E-Y-D-D-D-T-A-T-I-I-E-F-L-N-G-W-I-T-F-C-Q-S-I-I-S-T-L-T


### FUNCTION Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle ### SEQUENCE -M-V-S-R-K-A-V-A-V-L-L-M-V-H-V-A-V-M-L-A-S-Q-T-E-A-F-V-P-I-F-T-H-S-E-L-Q-R-I-R-E-K-E-R-N-K-G-Q-K-K-S-L-I-V-Q-Q-R-S-E-E-V-G-P-L-D-P-V-E-P-P-E-E-E-E-N-E-V-I-K-L-T-A-P-V-A-I-G-T-R-M-N-S-R-Q-L-E-K-Y-R-A-A-L-E-G-L-L-S-E-V-L-L-P-A-R-N-D-K


### FUNCTION Inhibitor of lipoprotein binding to the low density lipoprotein  Binds free fatty acids and reduces their intracellular esterification Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein ### SEQUENCE -M-R-L-L-L-S-L-P-V-L-L-V-A-L-S-V-V-L-E-R-P-A-P-A-Q-A-A-P-D-F-S-S-T-L-E-G-L-P-D-K-L-K-E-F-G-N-T-L-E-D-K-A-K-K-A-I-E-R-I-K-Q-S-D-L-P-A-K-T-R-N-W-F-T-E-T-F-G-K-V-R-D-T-F-K-A-T-F-S


### FUNCTION Component of the large ribosomal subunit The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell ### SEQUENCE -M-S-K-R-G-R-G-G-S-S-G-A-K-F-R-I-S-L-G-L-P-V-G-A-V-I-N-C-A-D-N-T-G-A-K-N-L-Y-I-I-S-V-K-G-I-K-G-R-L-N-R-L-P-A-A-G-V-G-D-M-V-M-A-T-V-K-K-G-K-P-X-L-R-K-K-V-H-P-A-V-V-I-R-Q-R-K-S-Y-R-R-K-D-G-V-F-L-Y-F-E-D-N-A-G-V-I-V-N-N-K-G-E-M-K-G-S-A-I-T-G-P-V-X-K-E-C-A-D-L-W-P-X-I-A-S-N-A-G-S-I-A


### FUNCTION Binds and deliver cytosolic copper to the copper ATPase proteins May be important in cellular antioxidant defense ### SEQUENCE -M-P-K-H-E-F-S-V-D-M-T-C-E-G-C-S-N-A-V-T-R-V-L-N-K-L-G-G-V-Q-F-D-I-D-L-P-N-K-K-V-C-I-N-S-E-H-S-V-D-T-L-L-E-T-L-G-K-T-G-K-A-V-S-Y-L-G-P-K


### FUNCTION Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells ### SEQUENCE -M-Y-K-M-Q-L-L-S-C-I-A-L-T-L-V-L-V-A-N-S-A-P-T-T-S-S-S-T-K-E-T-Q-Q-Q-L-E-Q-L-L-L-D-L-R-L-L-L-N-G-V-N-N-Y-E-N-P-Q-L-S-R-M-L-T-F-K-F-Y-T-P-K-K-A-T-E-L-T-H-L-Q-C-L-P-E-E-L-K-L-L-E-E-V-L-Y-L-A-P-N-K-N-F-H-L-T-D-I-K-E-L-M-S-N-I-N-V-T-L-L-K-L-K-G-S-E-T-R-F-K-C-E-Y-D-D-E-T-A-T-I-T-E-F-L-N-K-W-I-T-F-C-Q-S-I-F-S-T-L-T


### FUNCTION Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells ### SEQUENCE -M-Y-K-M-Q-L-L-S-C-I-A-L-T-L-A-L-V-A-N-G-A-P-T-S-S-S-T-E-N-T-K-K-Q-V-Q-S-L-L-Q-D-L-H-L-L-L-K-E-I-N-N-H-E-N-L-K-L-F-R-M-L-A-F-K-F-Y-M-P-K-K-A-T-E-L-K-H-L-Q-C-L-A-E-E-L-K-P-L-E-D-V-L-N-V-A-Q-S-K-T-Q-N-S-I-D-I-K-D-L-M-D-N-I-N-R-I-V-L-T-L-K-G-S-E-T-R-F-T-C-E-Y-D-D-E-T-V-T-A-V-E-F-L-N-K-W-I-T-F-C-Q-S-I-Y-S-T-M-T


### FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs Pol II is the central component of the basal RNA polymerase II transcription machinery It is composed of mobile elements that move relative to each other RPB11 is part of the core element with the central large cleft ### SEQUENCE -M-N-A-P-A-A-F-E-S-F-L-L-L-D-D-K-K-F-Y-I-E-K-D-T-K-V-P-N-A-A-I-F-T-I-M-K-E-D-H-T-L-G-N-M-L-K-I-Q-L-L-K-D-P-E-V-L-F-A-G-Y-K-N-P-H-P-L-E-H-K-I-L-L-R-I-Q-T-T-N-N-T-T-P-A-D-A-L-T-T-A-I-T-D-L-V-G-E-L-S-L-L-E-H-R-I-D-A-A-I-K-K-C-T-Q-S-G-D-Q-E-R-G-Y-N


### FUNCTION Required for ribosome biogenesis Part of a complex which catalyzes pseudouridylation of rRNA This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 Pseudouridine ### SEQUENCE -M-F-L-R-Y-F-L-D-E-N-Q-Q-R-V-Y-T-L-K-R-T-A-P-S-G-E-Q-T-L-T-A-H-P-A-R-F-S-P-E-D-K-N-S-K-Y-R-I-I-I-K-K-R-F-G-L-L-P-T-Q-K-A-K-T-V-C


### FUNCTION Stabilizer subunit of the dolichol-phosphate-mannose synthase complex ### SEQUENCE -M-V-S-Q-L-V-T-Y-S-A-H-V-I-L-F-V-L-V-W-L-L-A-Y-T-D-V-V-P-V-L-S-Y-L-P-E-C-L-H-C-L-V-N-Y-A-P-F-F-A-V-L-F-L-G-I-Y-A-V-F-N-V-V-Y-G-V-A-T-F-N-D-C-A-E-A-K-V-E-L-L-G-E-I-K-E-A-R-E-E-L-K-R-K-R-I-I-D


### FUNCTION Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions ### SEQUENCE -M-G-K-R-K-S-K-R-K-A-P-T-K-A-K-A-V-M-P-L-D-T-Q-F-N-C-P-F-C-N-H-E-R-V-C-E-V-K-M-D-R-E-K-N-V-G-Y-I-S-C-R-V-C-S-E-D-F-Q-T-N-I-N-Y-L-S-E-P-I-D-V-Y-S-D-W-V-D-A-C-E-Q-A-N-N-A


### FUNCTION Ribosomal protein required for normal mitochondrial function and normal larval development Thought to have a role in insulin/IGF signaling ### SEQUENCE -M-L-K-L-A-S-S-L-R-T-G-L-I-S-R-S-I-R-T-L-A-P-T-V-N-P-A-E-Q-Q-Q-V-Q-A-V-L-P-D-K-L-Y-S-S-V-E-I-E-Y-R-G-H-D-K-A-V-L-K-S-Y-T-S-F-L-Q-Q-V-C-Q-H-L-E-I-P-Q-G-R-L-E-V-L-P-Y-I-R-W-V-Q-P-A-L-R-S-K-F-V-H-K-K-Y-K-L-H-Y-E-T-R-T-H-I-S-K-L-E-I-L-N-V-T-G-S-T-A-S-T-F-L-E-Y-I-Q-R-N-I-P-E-G-V-G-M-R-V-G-F-T-E-L-Q-P-L-P-L-T-I-Q-K-N


### FUNCTION Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm May also be involved in ribosome biogenesis ### SEQUENCE -G-T-T-F-R-T-S-I-A-E-N-A-L-V-G-S-Y-A-V-V-N-N-K-G-C-M-V-H-P-K-T-P-A-Q-D-M-D-E-I-A-S-L-L-Q-V-P-V-V-A-G-T-I-N-R-G-N-A-A-I-G-S-G-L-V-V-N-D-W-A-A-F-C-G-L-N-T-T-A-T-E-I-T-V-V-E-R-I-F-Q-L-R-R-D-L-G-G-G-R-A-N-L-L-Q-Q-L-R-D-T-L-V-D-E-L-A


### FUNCTION Involved in calcium binding and microtubule stabilization ### SEQUENCE -M-K-V-Y-K-D-I-F-T-N-D-E-V-C-S-D-S-Y-I-Q-E-D-P-F-G-N-P-E-F-R-E-I-A-F-E-V-K-S-N-K-R-I-K-G-N-D-D-Y-G-I-A-D-N-S-E-D-A-V-D-G-M-G-A-D-V-E-H-V-I-D-I-V-D-S-F-Q-L-T-S-T-S-L-S-K-K-E-Y-S-A-Y-V-K-N-F-M-Q-R-I-L-K-H-L-E-E-K-K-P-D-R-V-D-I-F-K-T-K-A-Q-P-L-I-K-H-I-L-T-N-F-D-D-F-E-F-Y-M-G-E-S-L-D-M-E-A-G-L-I-Y-S-Y-Y-K-G-E-E-I-T-P-R-F-V-Y-I-S-D-G-L-F-E-E-K-Y


### FUNCTION Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels ### SEQUENCE -M-K-L-T-C-V-M-I-V-A-V-L-F-L-T-A-W-T-F-V-T-A-D-S-I-R-A-L-E-D-L-F-A-K-A-P-D-E-M-E-N-S-G-A-S-P-L-N-E-R-D-C-R-P-V-G-Q-Y-C-G-I-P-Y-E-H-N-W-R-C-C-S-Q-L-C-A-I-I-C-V-S


### FUNCTION Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels ### SEQUENCE -M-K-L-T-C-V-V-I-V-A-V-L-F-L-T-A-C-Q-L-I-T-A-E-T-Y-S-R-G-E-Q-K-H-R-A-L-S-S-T-D-K-N-S-K-L-T-R-T-C-N-T-P-T-Q-Y-C-T-L-H-R-H-C-C-S-L-Y-C-H-K-T-I-H-A-C-A


### FUNCTION Neuropeptide that triggers the performance of ecdysis behaviors at the end of a molt It triggers adult behavior patterns larval, pupal and adult ecdysis, and plasticization during the molt ### SEQUENCE -C-K-K-M-V-G-A-Y-F-E-G-E-L-C-A-D-A-C-L-K-F-K-G-K-M-C-P-T-A-R-T-S-P-P-S-R-P-S-S-T-S-L-S-S-R-C-C-S-I-K-S-L-C-K-A


### FUNCTION Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels ### SEQUENCE -M-K-L-T-C-M-V-I-V-A-V-L-L-L-T-A-C-Q-L-I-T-A-D-D-S-R-G-T-Q-K-H-R-S-L-R-S-T-T-K-V-S-K-A-T-D-C-I-E-A-G-N-Y-C-G-P-T-V-M-K-I-C-C-G-F-C-S-P-Y-S-K-I-C-M-N-Y-P-K-N


### FUNCTION Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels ### SEQUENCE -M-K-L-T-C-V-M-I-V-A-V-L-L-L-T-A-C-Q-L-I-T-A-D-D-S-R-G-T-Q-K-H-R-S-L-R-S-T-T-K-V-S-K-S-T-S-C-M-E-A-G-S-Y-C-G-S-T-T-R-I-C-C-G-Y-C-A-Y-F-G-K-K-C-I-D-Y-P-S-N


### FUNCTION Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors  and thus inhibit them ### SEQUENCE -M-G-M-R-M-M-F-T-V-F-L-L-V-V-L-A-T-T-V-V-S-F-T-S-G-R-R-T-F-H-G-R-N-A-A-A-K-A-S-G-L-V-S-L-T-D-R-R-P-E-C-C-S-H-P-A-C-N-V-D-H-P-E-I-C-R


### FUNCTION Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels ### SEQUENCE -M-K-L-T-C-V-V-I-V-A-V-L-F-L-T-A-W-T-F-V-T-A-V-P-H-S-S-N-A-L-E-N-L-Y-L-K-A-H-H-E-M-N-N-P-E-A-S-E-L-N-K-R-C-Y-D-G-G-T-S-C-D-S-G-I-Q-C-C-S-G-W-C-I-F-V-C-F


### FUNCTION Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels ### SEQUENCE -M-K-L-T-C-M-V-I-V-A-V-L-F-L-T-A-W-T-F-V-T-A-I-T-S-N-G-L-E-N-L-F-P-N-A-H-H-E-M-K-N-P-E-A-S-K-L-N-K-R-C-V-P-Y-E-G-P-C-N-W-L-T-Q-N-C-C-D-A-T-C-V-V-F-W-C-L


### FUNCTION Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca complex are a number of protein kinases and phosphatases ### SEQUENCE -M-A-D-Q-L-T-E-E-Q-I-A-E-F-K-E-A-F-S-L-F-D-K-D-G-N-G-N-I-T-T-K-E-L-G-T-V-M-R-S-L-G-Q-N-P-T-E-G-E-L-Q-D-M-I-N-E-V-D-A-D-G-N-G-T-I-D-F-P-E-F-L-T-M-M-A-R-K-M-K-D-T-D-S-E-E-E-I-R-E-A-F-K-V-F-D-K-D-G-N-G-F-I-S-A-A-E-L-R-H-V-M-T-N-P-G-E-K-L-T-D-E-E-V-D-E-M-I-R-E-A-D-I-D-G-D-G-Q-V-N-Y-E-E-F-V-K-M-M-T-S-K


### FUNCTION Component of the small ribosomal subunit The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell Required for pre-rRNA processing and maturation of 40S ribosomal subunits ### SEQUENCE -M-P-G-Y-T-V-K-D-V-N-Q-Q-E-F-V-K-A-L-A-A-F-F-K-K-S-G-K-L-K-K-P-D-W-V-D-T-V-K-L-G-K-H-K-E-L-A-P-F-D-I-D-W-Y-Y-I-R-T-A-S-V-A-R-H-L-Y-M-R-G-G-V-G-V-G-A-M-T-K-I-Y-G-G-R-Q-R-N-G-T-R-P-S-H-Y-S-R-G-S-R-N-V-A-R-K-V-L-Q-S-L-E-M-L-K-M-V-E-K-D-P-N-G-G-R-R-L-T-S-I-G-Q-R-D-M-D-R-I-A-G-Q-V-V-V-L-S-K-K-H


### FUNCTION Component of the large ribosomal subunit The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell ### SEQUENCE -V-G-I-V-G-K-Y-G-T-R-Y-G-A-S-L-R-K-M-V-K-K-I-E-I-T-Q-H-S-K-Y-T-C-T-F-C-G-K-T-K-M-K-R-R-A-V-G-I-W-H-C-G-S-C-M-K-T-V-A-G-G-A-W-T-Y-N-T-S-S-A-V-T-V-K-S-A-I-R-R-L-R-E-M-K-D-Q


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-E-Q-I-L-D-V-E-S-L-K-K-L-T-P-E-Q-Q-K-T-L-I-S-G-V-K-Q-Q-A-A-I-L-T-A-Q-N-M-I-T-D-X-S-E-R-C-L-T-K-C-I-T-X-P-G-S-A-L-S-X-T-E-R-Q-C-L-Q-R-C-M-D-R-F-M-E-T-Y-X-L-A-S-Q-X-L-Q-N-R-V-X-E-E-I-A-A-X-T-R-M-T


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-S-D-F-E-N-L-S-G-N-D-K-E-L-Q-E-F-L-L-I-E-K-Q-K-A-Q-V-N-A-Q-I-H-E-F-N-E-I-C-W-E-K-C-I-G-K-P-S-T-K-L-D-H-A-T-E-T-C-L-S-N-C-V-D-R-F-I-D-T-S-L-L-I-T-Q-R-F-A-Q-M-L-Q-K-R-G-G-G-D-L


### FUNCTION Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems ### SEQUENCE -M-V-I-T-L-P-K-L-K-Y-A-L-N-A-L-S-P-H-I-S-E-E-T-L-N-F-H-Y-N-K-H-H-A-G-Y-V-N-K-L-N-T-L-I-K-D-T-P-F-A-E-K-S-L-L-D-I-V-K-E-S-S-G-A-I-F-N-N-A-A-Q-I-W-N-H-T-F-Y-W-D-S-M-G-P-D-C-G-G-E-P-H-G-E-I-K-E-K-I-Q-E-D-F-G-S-F-N-N-F-K-E-Q-F-S-N-I-L-C-G-H-F-G-S-G-W-G-W-L-A-L-N-N-N-N-K-L-V-I-L-Q-T-H-D-A-G-N-P-I-K-D-N-T-G-I-P-I-L-T-C-D-I-W-E-H-A-Y-Y-I-D-Y-R-N-D-R-A-S-Y-V-K-A-W-W-N-L-V-N-W-N-F-A-N-E-N-L-K-K-A-M-Q-K


### FUNCTION Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems ### SEQUENCE -M-V-I-T-L-P-K-L-K-Y-A-L-N-A-L-S-P-H-I-S-E-E-T-L-N-F-H-Y-N-K-H-H-A-G-Y-V-N-K-L-N-T-L-I-K-D-T-P-F-A-E-K-S-L-L-D-I-V-K-E-S-S-G-A-I-F-N-N-A-A-Q-I-W-N-H-T-F-Y-W-D-S-M-G-P-D-C-G-G-E-P-H-G-G-I-K-E-K-I-Q-E-D-F-G-S-F-N-N-F-K-E-Q-F-S-N-I-L-C-G-H-F-G-S-G-W-G-W-L-A-L-N-N-N-N-K-L-V-I-L-Q-T-H-D-A-G-N-P-I-K-D-N-T-G-I-P-I-L-T-C-D-I-W-E-H-A-Y-C-I-D-Y-R-N-D-R-A-S-Y-V-K-A-W-W-N-L-V-N-W-N-F-A-N-E-N-L-K-K-A-M-Q-K


### FUNCTION Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis They bind voltage-independently at site-4 of sodium channels ### SEQUENCE -M-K-L-F-L-L-L-V-I-F-A-S-M-L-N-D-G-L-V-N-A-D-G-Y-I-R-G-S-D-G-C-K-V-S-C-L-W-G-N-D-F-C-D-K-V-C-K-K-S-G-G-S-Y-G-Y-C-W-T-W-G-L-A-C-W-C-E-G-L-P-D-N-E-K-W-K-Y-E-S-N-T-C-G-S-K-K


### FUNCTION May play a role in lens epithelial cell differentiation ### SEQUENCE -M-Q-P-R-T-Q-P-L-A-Q-T-L-P-F-F-L-G-G-A-P-R-D-T-G-L-R-V-P-V-I-K-M-G-T-G-W-E-G-F-Q-R-T-L-K-E-V-A-Y-I-L-L-C-C-W-C-I-K-E-L-L-D


### FUNCTION Transcription repressor involved in the exit of embryonic stem cells  from self-renewal Acts by repressing expression of KLF4 ### SEQUENCE -M-A-R-G-Q-Q-K-I-Q-S-Q-Q-K-N-A-K-K-Q-A-G-Q-K-K-K-Q-G-H-D-Q-K-A-A-A-K-A-A-L-I-Y-T-C-T-V-C-R-T-Q-M-P-D-P-K-T-F-K-Q-H-F-E-S-K-H-P-K-T-P-L-P-P-E-L-A-D-V-Q-A


### FUNCTION Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases ### SEQUENCE -M-A-E-L-K-S-F-T-L-A-D-L-S-Q-H-T-T-K-D-S-L-Y-L-A-I-H-G-K-V-Y-D-C-T-G-F-I-D-E-H-P-G-G-E-E-V-L-I-D-E-A-G-R-D-A-T-E-S-F-E-D-V-G-H-S-D-E-A-R-D-I-M-S-K-L-L-V-G-E-F-K-T-D-S-S-E-K-P-K-A-K-S-P-S-S-S-T-P-R-P-I-P-A-A-E-P-S-D-S-G-S-L-Q-Y-V-L-A-L-A-V-V-A-G-C-V-I-W-K-V-L-L


### FUNCTION Subunit of the V1 complex of vacuolar ### SEQUENCE -M-A-T-S-Q-A-D-A-R-D-R-Q-F-L-A-V-I-G-D-E-D-S-V-T-G-L-L-L-A-G-I-G-H-V-T-A-P-P-D-S-Q-K-N-F-L-V-V-D-N-K-T-D-N-A-A-I-E-A-A-F-D-R-F-T-T-E-R-K-D-I-G-I-V-L-I-N-Q-H-I-A-D-R-I-R-H-R-V-D-T-H-T-A-A-F-P-T-V-L-E-I-P-S-K-D-H-P-Y-D-P-E-K-D-S-V-L-R-R-V-R-R-L-F-G-E


### FUNCTION The complex LTO1YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly  complex machinery May be required for biogenesis of the large ribosomal subunit and initiation of translation ### SEQUENCE -M-D-W-E-E-V-T-K-L-E-E-N-E-Y-K-R-G-Y-D-E-G-I-L-K-G-I-E-Q-G-Y-E-E-A-F-L-F-G-L-E-H-A-Y-N-K-Y-L-L-A-G-E-I-Y-G-R-V-C-F-W-L-K-E-E-N-S-Q-H-P-K-I-K-K-A-H-R-H-L-E-Q-L-K-S-L-L-E-S-L-P-T-N-N-E-L-E-E-T-D-A-G-F-D-S-Y-W-N-K-I-T-A-K-A-K-V-V-S-S-L-L-G-T-K-I-L-P-A-E-K-I-D-A-N-D-G-F-E


### FUNCTION Component of the mitochondrial ribosome , a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane mL54 may have a meiosis-specific role as it accumulates during the middle stage of sporulation ### SEQUENCE -M-P-F-I-E-S-M-A-P-L-S-R-A-I-T-R-G-I-S-Q-F-S-C-Y-S-N-T-L-V-L-R-S-S-R-N-S-S-S-S-L-V-K-R-S-Y-V-S-S-R-V-S-P-K-K-P-Q-H-N-S-D-A-T-S-S-A-Q-K-V-A-N-K-T-H-T-S-S-V-L-P-G-T-I-L-K-G-L-C-I-K-A-G-G-V-D-P-V-A-R-E-D-H-E-Y-P-E-W-L-W-S-L-L-D-E-P-A-P-N-S-K-T-A-R-S-H-A-R-K-S-A-I-R-A-A-N-F-L-T-K-K


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-D-G-L-N-A-A-E-Q-R-E-L-A-N-R-M-E-R-K-Q-M-K-E-F-M-T-M-Y-S-K-L-V-Q-R-C-F-D-D-C-V-N-D-F-T-T-K-S-L-I-S-R-E-E-G-C-V-M-R-C-V-D-K-F-M-K-G-S-Q-R-L-N-E-R-F-Q-E-Q-N-A-A-M-M-Q-S-G-Q-L-P-G-R


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-S-F-L-F-G-G-A-P-K-M-S-S-E-Q-K-I-A-A-A-E-T-E-V-E-M-I-T-D-M-F-N-R-L-S-E-S-C-S-K-K-C-I-P-N-D-Y-R-E-G-D-L-N-K-G-E-S-V-C-L-D-R-C-V-G-K-F-F-E-V-N-I-K-V-S-E-K-M-Q-G-V-A-G-Q-Q-Q-G-G-A-G-L-S-L


### FUNCTION Binds and compacts DNA  to form nucleosome-like structures ### SEQUENCE -M-A-E-L-P-I-A-P-V-D-R-L-I-R-K-A-G-A-A-R-V-S-E-E-A-A-K-V-L-A-E-H-L-E-E-K-A-L-E-I-A-K-K-A-V-A-L-A-Q-H-A-G-R-K-T-V-K-A-E-D-I-K-L-A-I-K-S


### FUNCTION Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA ### SEQUENCE -M-A-R-V-A-V-V-V-K-V-Y-P-D-D-V-S-I-D-P-K-T-L-A-E-R-I-K-S-K-L-P-S-G-Y-E-V-L-A-E-G-E-E-P-I-A-F-G-L-K-A-L-K-L-V-I-A-M-N-E-D-T-E-G-G-T-E-E-V-E-Q-L-L-K-N-I-E-G-V-Q-E-V-E-V-E-N-V-S-R-M-Q


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-P-K-S-R-T-C-S-F-C-G-G-S-I-E-P-G-T-G-L-M-Y-V-L-R-N-G-Q-I-L-W-F-C-S-S-K-C-Y-K-N-F-V-K-L-R-R-K-P-D-K-L-E-W-V-R-K-V-K-K-S-L-L-D


### FUNCTION Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate ### SEQUENCE -M-S-H-E-E-L-A-E-V-L-A-K-V-L-K-K-R-G-A-V-L-R-G-D-F-V-L-S-S-G-R-R-S-S-V-Y-I-D-M-R-R-L-L-G-D-E-S-S-Y-S-V-A-L-D-L-L-L-E-V-G-G-Q-D-L-A-R-S-S-A-V-I-G-V-A-T-G-G-L-P-W-A-A-M-L-A-L-R-L-S-K-P-L-G-Y-V-R-P-E-R-K-G-H-G-T-L-S-Q-V-E-G-D-P-P-K-G-R-V-V-V-V-D-D-V-A-T-T-G-T-S-I-A-K-S-I-E-V-L-R-S-N-G-Y-T-V-G-T-A-L-V-L-V-D-R-G-E-G-A-G-E-L-L-A-R-M-G-V-R-L-V-S-V-A-T-L-K-T-I-L-E-K-L-G-W-G-G-E


### FUNCTION Stimulates transcription elongation ### SEQUENCE -M-E-G-G-V-D-A-R-F-Y-A-I-L-V-T-S-G-A-E-V-N-V-A-T-I-I-A-E-R-A-R-A-L-G-L-D-I-R-S-I-I-V-P-P-R-I-K-G-Y-V-I-L-E-A-H-D-P-G-D-V-Y-D-A-T-R-G-L-R-H-V-K-R-R-R-P-L-I-L-K-F-E-E-V-M-K-L-V-K-P-E-V-E-I-P-A-L-K-P-G-Q-V-V-E-I-V-A-G-A-F-K-G-M-K-A-R-V-I-D-V-N-Q-S-K-G-Q-V-T-V-S-L-L-E-P-L-F-R-A-T-A-T-I-P-I-D-E-V-R-P-V-E-E


### FUNCTION Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors ### SEQUENCE -M-V-K-G-S-Q-V-K-P-S-T-T-E-L-L-L-K-A-V-S-A-K-A-P-S-G-D-P-I-H-Q-K-I-G-D-L-P-F-E-K-I-V-E-I-A-I-E-K-K-P-D-L-L-A-K-T-L-K-A-A-V-K-T-I-L-G-S-A-R-S-I-G-V-T-V-D-G-K-D-P-K-E-V-T-R-Q-V-D-E-G-V-Y-D-A-V-L-A-K-Y-E-E-K-W-E-E-A-E-G


### FUNCTION Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors ### SEQUENCE -M-A-Q-E-G-K-A-Y-I-H-L-A-L-A-I-Y-Y-A-G-G-K-I-D-E-E-T-L-K-K-A-A-E-A-I-G-M-Q-V-D-E-A-K-I-K-M-L-V-A-S-L-E-E-V-N-L-E-E-V-L-K-Q-A-V-A-A-P-V-A-A-A-A-A-A-P-A-A-A-P-A-A-E-E-K-A-E-E-E-K-K-E-E-E-E-E-K-K-E-E-E-V-D-L-S-G-L-S-G-M-F-G-F


### FUNCTION Functions by promoting the formation of the first peptide bond ### SEQUENCE -M-S-V-N-Y-A-T-L-G-D-L-K-K-G-S-Y-I-V-I-D-G-E-P-C-R-I-V-E-M-S-R-A-K-T-G-K-H-G-S-A-K-A-H-V-V-A-I-C-V-F-S-G-Q-K-K-S-L-V-A-P-V-D-T-R-V-Q-I-P-V-I-E-K-R-L-G-Q-V-L-A-D-M-G-D-M-V-Q-I-M-D-L-E-T-Y-D-T-F-E-V-E-K-P-G-G-N-E-E-E-E-Q-L-A-A-K-L-Q-P-G-V-T-V-E-Y-W-L-I-M-G-K-P-K-I-I-R-I-R-S-S-S-S


### FUNCTION Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs ### SEQUENCE -M-K-P-G-G-P-Y-G-D-V-Y-V-L-R-L-G-H-R-P-E-R-D-K-R-V-T-T-H-V-A-L-V-A-R-A-F-G-A-N-G-F-V-L-E-G-V-C-D-E-G-V-V-E-S-V-R-R-V-V-A-R-W-G-G-P-F-T-V-E-C-G-V-S-G-R-R-Y-V-R-M-W-R-E-G-G-G-E-V-V-H-L-T-M-Y-G-V-N-V-D-D-V-A-P-V-I-A-A-S-P-R-R-K-L-V-V-V-G-A-E-K-V-E-R-F-Y-Y-E-E-A-D-W-N-V-S-V-G-T-Q-P-H-S-E-V-A-A-L-A-L-F-L-D-R-L-F-R-G-E-W-R-F-I-D-Y-S-G-G-F-L-R-V-M-E-S-Q-R-G-K-R-V-E-R-K-G


### FUNCTION Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein  and RNA polymerase recruitment Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes ### SEQUENCE -M-K-G-K-G-R-N-R-A-V-K-S-L-E-I-Y-V-R-K-L-A-Q-A-N-G-I-K-P-E-M-A-A-H-I-F-H-L-I-Y-E-E-T-P-N-G-G-I-S-D-D-D-L-E-S-L-T-G-Y-K-Q-S-D-I-R-R-I-L-R-L-L-G-D-K-R-I-I-V-S-R-K-G-R-H-P-R-K-E-A-T-R-Y-F-W-R-I-D-S-D-T-I-N-V-S-L-L-T-L-K-K-K-V-L-E-K-L-V-V-K-E-A-H-D-S-G-N-S-Y-Y-T-C-P-R-C-G-S-K-Y-S-F-D-E-A-F-T-L-D-F-T-C-P-R-C-G-E-V-L-E-E-A-D-S-R-E-G-L-E-R-L-R-R-T-I-D-A-L-R-E-E-I-A-R-D-E-S-R-I-Y-R-S


### FUNCTION A putative type II restriction enzyme, its methylase would be APE_2002 ### SEQUENCE -M-P-V-E-V-I-P-V-L-H-N-V-S-S-V-Q-R-V-V-D-M-A-R-L-S-Y-S-L-G-L-D-T-L-V-V-T-K-A-Y-G-G-A-A-Q-S-G-V-P-E-A-M-R-L-A-L-K-L-G-K-S-L-V-V-L-P-E-L-R-D-A-V-N-L-L-S-P-T-H-V-L-A-V-T-P-S-R-A-E-R-L-V-G-P-G-G-L-E-G-L-E-G-R-V-L-V-V-F-S-G-G-E-P-E-L-D-P-S-E-A-A-G-A-I-R-V-Y-I-E-G-V-E-G-K-V-G-P-I-A-E-A-A-L-I-L-Y-F-L-L-R-G-G-G-D-G-R-G


### FUNCTION DNA-dependent RNA polymerase  catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates ### SEQUENCE -M-S-S-K-T-R-K-S-S-R-V-I-L-E-H-E-Y-V-P-E-H-R-L-L-S-I-E-E-A-V-Q-V-L-K-M-L-G-I-K-P-W-Q-L-P-K-I-S-V-N-D-P-I-A-R-L-L-K-A-K-P-G-D-I-I-E-I-T-R-R-S-Y-T-A-G-E-A-K-Y-Y-R-F-V-V-A-Y-Q-K-G-V-K


### FUNCTION With S4 and S5 plays an important role in translational accuracy Located at the interface of the 30S and 50S subunits ### SEQUENCE -M-T-G-K-K-A-P-A-G-L-F-A-A-R-K-L-R-R-K-R-L-K-F-R-W-S-Q-R-E-F-R-I-R-M-L-D-L-K-R-K-Y-D-P-L-E-G-A-P-M-A-R-G-I-V-L-E-K-V-G-V-E-A-R-Q-P-N-S-A-L-R-K-C-V-R-V-Q-L-V-K-N-K-K-V-V-T-A-F-V-P-R-D-G-G-I-L-Y-V-D-E-H-D-E-V-I-I-E-G-I-G-G-P-R-G-R-S-M-G-D-I-P-G-V-R-Y-R-V-V-M-V-N-G-V-S-L-K-A-L-W-E-G-K-K-Q-K-P-R-K


### FUNCTION Involved in the binding of tRNA to the ribosomes ### SEQUENCE -M-A-F-K-L-R-I-W-L-W-S-T-N-V-R-S-L-E-N-V-V-E-Q-I-R-N-I-A-N-K-T-G-I-R-M-R-G-P-V-P-L-P-V-K-R-L-E-V-P-V-F-R-L-P-H-G-E-G-S-K-Y-W-E-H-W-E-M-K-V-H-K-R-L-I-D-L-E-A-D-E-R-V-L-R-H-L-M-R-I-K-V-P-E-D-V-Y-I-E-I-K-Q-M-T-G


### FUNCTION Binds double-stranded DNA tightly but without sequence specificity It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture However, it does not significantly compact DNA Binds rRNA and mRNA in vivo May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes ### SEQUENCE -M-S-I-E-P-Q-K-P-N-T-I-L-V-G-R-K-P-T-I-N-Y-V-M-A-A-L-K-L-L-N-E-E-G-A-P-E-V-V-I-K-A-R-G-R-N-I-C-N-A-V-D-T-V-E-M-L-K-N-L-F-I-K-N-L-V-I-K-K-V-N-I-Y-S-E-S-L-D-S-E-G-K-K-K-V-S-A-I-E-I-V-V-A-K-G


### FUNCTION Binds double-stranded DNA tightly but without sequence specificity It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture However, it does not significantly compact DNA Binds rRNA and mRNA in vivo May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes ### SEQUENCE -M-A-C-E-G-A-P-E-V-R-I-G-R-K-P-V-M-N-Y-V-L-A-I-L-T-T-L-M-E-Q-G-T-N-Q-V-V-V-K-A-R-G-R-N-I-N-R-A-V-D-A-V-E-I-V-R-K-R-F-A-K-N-I-E-I-K-D-I-K-I-D-S-Q-E-I-E-V-Q-T-P-E-G-Q-T-R-T-R-R-V-S-S-I-E-I-C-L-E-K-A-G-E-S-A


### FUNCTION Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester ### SEQUENCE -M-V-G-R-L-A-R-L-R-D-S-I-A-H-T-G-V-P-M-K-T-V-E-D-E-N-F-H-I-T-L-R-F-I-G-E-V-S-E-P-V-A-A-E-I-G-E-R-L-A-S-I-R-F-E-R-F-R-I-E-L-R-G-L-G-A-F-P-R-P-D-R-P-R-V-V-W-V-G-V-G-G-G-A-G-E-L-R-R-I-R-D-E-V-E-R-I-L-T-S-M-G-F-S-P-E-K-Q-E-F-H-P-H-V-T-L-A-R-I-K-G-A-R-N-L-P-A-L-V-K-L-L-R-E-M-G-D-V-E-V-G-S-V-E-V-S-S-I-R-L-K-Q-S-I-L-T-R-Q-G-P-I-Y-K-T-L-Y-E-V-K-A-A-S-S-G-R-V


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-L-L-A-G-G-E-A-R-E-I-V-V-D-G-S-G-M-I-M-G-R-L-A-S-V-V-A-K-L-L-L-A-G-W-R-V-N-V-V-N-A-E-K-I-V-L-S-G-D-P-R-M-V-V-E-S-Y-R-T-T-V-L-G-V-K-S-H-F-S-H-K-W-R-P-K-R-P-R-T-P-Q-R-L-F-K-H-A-V-R-G-M-L-P-K-N-K-A-R-G-R-R-A-L-A-R-L-R-V-Y-V-G-V-P-D-E-L-K-G-R-E-F-V-R-F-P-E-A-D-A-S-R-L-S-S-H-Y-I-E-L-G-A-V-A-R-Q-L-G-W-K-G-G-V-E-K


### FUNCTION Located on the platform of the 30S subunit ### SEQUENCE -M-A-M-Y-P-R-E-L-K-W-G-V-A-H-I-Y-S-S-F-N-N-T-H-V-H-I-T-D-L-T-G-A-E-T-V-A-R-V-T-G-G-M-V-V-K-A-D-R-E-K-P-S-P-Y-A-A-M-I-A-A-S-R-A-A-Q-K-A-M-E-R-G-I-A-A-I-H-I-K-V-R-A-P-G-G-H-G-P-K-T-P-G-P-G-A-Q-A-A-I-R-A-L-A-R-A-G-F-I-I-G-R-I-E-D-V-T-P-I-P-H-D-T-T-R-R-P-G-G-R-R-G-R-R-V


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit ### SEQUENCE -M-G-D-P-R-K-P-R-K-K-W-E-G-P-K-H-P-W-I-K-E-R-L-E-R-E-R-E-L-M-G-R-Y-G-L-R-N-K-K-E-L-W-K-A-E-T-L-A-R-R-F-R-H-R-A-R-S-L-L-G-L-P-P-E-V-R-R-E-A-S-R-V-L-V-E-S-L-Y-R-M-G-L-I-D-N-P-N-V-D-I-D-E-V-L-G-I-N-A-E-K-V-L-E-R-R-L-Q-T-I-V-Y-K-K-G-L-A-K-T-I-Y-Q-A-R-Q-L-V-V-H-G-H-I-A-I-A-G-R-R-V-T-S-P-G-Y-L-V-S-R-E-E-E-K-L-I-D-Y-A-P-G-S-P-F-K-E-R-A-E-E-A-A-Q-A


### FUNCTION Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA In the 70S ribosome it contacts the 23S rRNA , connecting the 2 subunits ### SEQUENCE -M-A-G-E-T-S-F-K-Y-I-V-R-I-A-G-V-D-I-D-G-D-L-K-L-P-Y-G-L-A-S-I-K-G-I-G-Y-T-T-A-M-A-V-I-R-M-L-G-L-D-P-E-K-K-V-G-F-L-T-E-E-E-I-R-R-L-D-E-V-L-R-D-I-T-Q-L-G-L-P-K-W-L-Y-N-R-R-K-D-Y-E-T-G-K-D-L-H-L-I-G-S-E-L-I-F-Y-A-R-R-D-I-E-R-E-M-K-I-G-S-W-R-G-I-R-H-K-Y-G-L-K-V-R-G-Q-R-T-R-T-T-G-R-L-G-M-T-I-G-V-R-K-K-R


### FUNCTION Catalyzes the hydrolysis of inorganic pyrophosphate  forming two phosphate ions ### SEQUENCE -M-T-G-C-L-K-I-G-P-G-D-E-A-P-D-V-V-N-V-V-I-E-I-P-M-N-S-S-V-K-Y-E-F-D-K-E-A-C-I-V-K-V-D-R-F-L-Y-T-S-M-V-Y-P-F-N-Y-G-F-I-P-G-T-L-E-E-D-G-D-P-V-D-V-L-V-I-S-R-E-P-V-A-P-G-S-L-I-E-A-V-P-V-A-V-L-D-M-E-D-E-E-G-P-D-S-K-V-V-A-V-P-K-A-K-L-D-P-L-F-A-S-Y-K-D-V-G-D-I-P-D-A-L-K-S-K-I-K-H-F-F-E-H-Y-K-E-L-E-P-G-K-W-V-R-V-T-G-W-R-P-A-A-D-A-K-E-I-I-R-R-A-I-E-R-Y-K-G-A


### FUNCTION Involved in allosteric regulation of aspartate carbamoyltransferase ### SEQUENCE -M-E-G-E-G-L-L-V-R-K-I-R-S-G-V-V-I-D-H-I-P-P-G-R-A-F-T-M-L-K-A-L-G-L-L-P-P-R-G-Y-R-W-R-I-A-V-V-I-N-A-E-S-S-K-L-G-R-K-D-I-L-K-I-E-G-Y-K-P-R-Q-R-D-L-E-V-L-G-I-I-A-P-G-A-T-F-N-V-I-E-D-Y-K-V-V-E-K-V-K-L-K-L-P-E-E-S-Q-G-V-L-R-C-P-N-P-T-C-I-T-R-K-E-R-E-K-A-V-S-K-M-V-L-V-S-Q-D-P-P-A-Y-R-C-V-Y-C-G-T-T-V-M-G-D-E-I-H-D-L-I-S-P


### FUNCTION The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis ### SEQUENCE -M-T-G-E-G-Y-K-Q-A-I-V-V-R-R-D-L-G-M-G-R-G-K-A-A-A-Q-A-A-H-A-S-C-E-A-V-F-L-I-L-E-S-G-R-P-E-W-R-R-W-L-E-M-W-R-L-Q-G-Q-A-K-V-V-L-R-V-E-S-L-A-E-L-Q-E-V-Y-S-K-A-V-E-E-G-L-P-A-S-F-V-R-D-A-G-K-T-Q-L-E-P-G-T-P-T-A-A-A-V-G-P-A-P-S-R-L-V-D-R-I-T-G-G-L-K-L-F


### FUNCTION Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor  to the flavin N5 and C6 atoms of FMN ### SEQUENCE -M-S-C-R-P-S-S-V-S-I-A-V-T-G-S-S-G-V-R-V-A-L-R-L-L-E-A-L-K-G-E-V-E-I-R-G-I-I-L-T-R-G-A-E-E-V-A-R-Y-E-E-G-I-E-P-E-D-L-R-R-L-L-R-S-Y-A-P-L-Y-M-E-N-D-M-S-S-P-L-A-S-S-S-N-Q-P-D-A-M-A-I-V-P-A-S-M-K-T-V-G-L-I-A-R-G-I-P-S-S-L-P-A-R-A-A-L-A-V-L-R-L-G-R-R-L-V-V-A-P-R-E-T-P-L-G-V-V-E-L-E-N-M-L-A-I-A-R-M-G-G-I-V-V-P-L-T-L-S-F-Y-I-K-P-S-S-V-E-D-L-V-D-F-A-A-G-K-V-L-D-A-L-G-V-K-V-D-V-Y-R-R-W-R-G-P-E-E-G-D


### FUNCTION Endonuclease that removes tRNA introns Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp ### SEQUENCE -M-G-D-R-C-A-P-I-K-A-S-G-V-L-I-G-D-S-V-L-V-T-D-V-E-Q-A-R-S-L-Y-S-C-G-Y-Y-G-Q-P-L-D-V-E-K-P-R-G-A-D-F-E-G-P-L-R-L-S-L-I-E-S-L-Y-L-A-E-K-G-V-L-E-V-A-K-P-D-G-S-S-V-G-V-E-D-L-R-T-A-V-R-G-N-P-R-F-S-M-L-Y-N-I-Y-R-D-L-R-E-R-G-F-V-V-R-S-G-L-K-F-G-S-D-F-A-V-Y-R-L-G-P-G-I-D-H-A-P-F-I-V-H-A-Y-S-P-E-D-N-I-D-P-V-E-I-V-R-A-G-R-L-S-H-S-V-R-K-K-F-V-F-A-V-T-R-G-G-D-V-S-Y-L-M-I-D-W-F-R-P


### FUNCTION eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA ### SEQUENCE -M-S-G-S-V-L-D-E-E-A-E-K-L-M-D-Y-D-Y-L-L-E-K-L-Y-K-K-V-P-P-K-S-G-T-S-E-Y-R-I-P-E-P-Q-I-I-R-I-G-S-Q-T-V-I-R-N-F-R-E-I-A-Q-A-L-K-R-D-P-K-L-V-A-R-Y-L-Q-K-E-L-A-T-A-A-S-Y-E-E-E-S-G-Q-L-I-L-N-V-K-V-S-R-K-V-V-N-Q-F-L-Q-L-F-M-K-T-Y-V-R-C-P-T-C-G-S-I-D-T-K-L-L-R-Q-E-R-A-Y-M-L-K-C-E-A-C-G-A-E-Q-P-V-K-P-I


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-V-E-R-L-P-P-E-V-E-A-K-Y-T-K-Y-L-K-L-R-E-T-L-S-V-V-M-R-E-K-A-T-V-E-A-G-L-A-E-V-E-S-V-L-K-E-L-E-G-L-P-E-D-A-E-L-Y-R-L-T-G-F-V-L-V-K-K-S-K-N-E-V-V-E-D-L-N-K-R-K-E-D-L-E-L-K-L-K-V-L-K-S-Q-E-E-H-L-K-K-E-L-E-R-I-E-S-E-L-R-R-L-L-Q-G-G-A-V-G-G-A-K-G-A


### FUNCTION Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-uracil with 3,4-dihydroxy-2-butanone 4-phosphate This is the penultimate step in the biosynthesis of riboflavin ### SEQUENCE -M-S-C-G-D-K-I-R-I-A-I-V-V-S-E-F-N-Y-D-V-T-R-V-M-E-E-K-A-I-D-H-A-R-F-L-G-A-E-V-S-L-V-A-R-S-P-G-T-F-D-T-P-F-I-V-S-R-L-L-A-T-H-S-E-V-D-A-V-A-V-L-G-A-V-I-K-G-D-T-K-H-D-E-V-V-A-H-Q-A-A-R-K-L-L-D-L-S-I-E-Y-G-K-P-V-T-L-G-I-I-G-P-G-A-S-R-L-E-A-I-E-R-A-E-E-Y-A-R-R-A-V-E-S-A-V-K-L-A-R-R-S-K-E-L-S-G-E-C


### FUNCTION Catalyzes the conversion of ### SEQUENCE -M-S-G-A-G-M-V-D-I-T-A-K-E-P-V-R-R-E-A-V-A-S-G-F-I-S-L-K-R-E-T-V-K-A-I-R-E-G-R-V-E-K-G-D-V-I-S-V-A-S-V-A-A-V-L-A-V-K-E-T-P-R-L-I-P-L-T-H-P-I-P-I-E-K-V-E-P-E-V-R-V-R-D-D-G-V-E-V-R-V-R-V-A-T-T-A-K-T-G-V-E-M-E-A-L-A-G-V-T-A-A-L-L-T-V-W-D-M-V-K-S-L-E-K-D-E-T-G-N-Y-P-D-T-V-I-T-G-V-K-V-E-V-K-R-K-G


### FUNCTION Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends ### SEQUENCE -M-R-L-R-R-L-A-G-R-R-P-R-R-R-Y-V-A-F-E-V-L-S-L-D-G-P-P-P-G-K-G-E-F-E-E-A-L-R-G-V-Y-L-K-A-F-G-A-E-S-L-A-L-A-R-P-R-I-V-Y-Y-E-E-E-S-G-R-G-V-V-A-V-V-R-D-Y-R-Y-H-I-L-A-A-L-G-L-V-R-M-A-G-G-R-R-V-L-V-V-P-L-R-T-S-G-T-V-K-G-A-L-R-A-F-R-S-P-G-A-P-G-R-G-G-V


### FUNCTION Toxic component of a type II toxin-antitoxin  system An RNase ### SEQUENCE -M-R-G-S-T-Q-G-C-S-P-T-G-R-E-A-I-V-L-D-T-G-A-F-I-A-G-K-A-A-A-L-P-G-R-L-A-T-P-P-R-V-L-E-E-V-R-D-R-G-S-R-S-L-L-E-L-L-Q-S-T-G-R-L-E-V-L-A-P-S-T-R-A-L-E-R-A-R-E-E-A-R-R-A-G-V-L-G-R-L-S-G-A-D-L-E-V-L-A-L-A-L-D-L-A-W-Q-G-C-R-V-A-V-A-T-D-D-Y-T-L-Q-R-L-A-A-R-L-G-L-G-V-V-R-L-R-Y-R-G-A-V


### FUNCTION May be involved in maturation of the 30S ribosomal subunit ### SEQUENCE -M-V-N-A-L-E-V-P-A-D-L-L-I-R-R-V-A-R-K-L-K-E-K-Y-P-Q-V-K-P-P-A-W-A-Y-F-A-K-T-G-P-H-K-E-R-P-P-T-D-R-D-W-W-Y-V-R-A-A-S-I-L-R-K-L-Y-K-S-P-E-P-I-G-I-E-T-F-R-T-I-Y-G-G-R-Q-N-R-G-S-A-P-E-H-F-R-K-A-G-G-S-V-P-R-K-I-L-Q-Q-L-E-E-A-G-L-V-V-K-V-P-G-R-G-R-T-I-S-P-A-G-R-S-L-L-D-T-T-A-R-E-I-M-E-E-L-V-K-T-R-P-E-L-E-R-Y-L


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-A-Q-Q-M-P-S-P-E-E-I-A-A-Q-L-Q-M-I-R-D-Q-I-A-E-L-Q-G-V-L-A-Q-L-E-L-R-L-R-S-V-Q-A-A-K-E-T-V-E-K-A-A-G-Q-D-G-E-T-L-F-P-G-D-P-E-L-N-T-I-L-K-A-R-L-L-E-P-G-K-A-I-V-H-L-G-L-N-V-Y-A-K-L-D-T-A-K-A-T-E-I-L-A-K-K-E-D-A-L-K-R-S-L-E-T-L-K-Q-E-L-D-K-L-S-R-T-H-D-Q-Y-L-Q-L-L-Q-A-L-T-A-G-Q-A-A-Q-Q-A-G-Q-Q-Q-K-Q-G-S


### FUNCTION The glycine cleavage system catalyzes the degradation of glycine The H protein shuttles the methylamine group of glycine from the P protein to the T protein ### SEQUENCE -M-G-G-Q-V-I-E-V-E-V-A-G-V-R-F-L-L-R-K-D-L-R-Y-T-E-S-D-E-W-A-R-L-E-D-G-V-A-T-V-G-I-T-D-F-A-Q-K-E-L-K-D-I-V-G-V-E-L-P-E-K-G-R-K-V-K-K-G-E-A-V-A-T-V-E-S-I-K-A-T-A-D-I-Y-A-P-L-S-G-E-I-V-D-V-N-E-K-L-L-D-Q-P-E-L-I-N-D-D-P-Y-G-E-G-W-I-F-K-I-K-V-E-D-P-G-E-F-E-S-L-L-T-P-E-Q-Y-V-E-S-V-R-K-R-K-E


### FUNCTION S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72 ### SEQUENCE -M-G-S-I-E-E-V-L-L-E-E-R-L-I-G-Y-L-D-P-G-A-E-K-V-L-A-R-I-N-R-P-S-K-I-V-S-T-S-S-C-T-G-R-I-T-L-I-E-G-E-A-H-W-L-R-N-G-A-R-V-A-Y-K-T-H-H-P-I-S-R-S-E-V-E-R-V-L-R-R-G-F-T-N-L-W-L-K-V-T-G-P-I-L-H-L-R-V-E-G-W-Q-C-A-K-S-L-L-E-A-A-R-R-N-G-F-K-H-S-G-V-I-S-I-A-E-D-S-R-L-V-I-E-I-M-S-S-Q-S-M-S-V-P-L-V-M-E-G-A-R-I-V-G-D-D-A-L-D-M-L-I-E-K-A-N-T-I-L-V-E-S-R-I-G-L-D-T-F-S-R-E-V-E-E-L-V-E-C-F


### FUNCTION Specifically catalyzes the N1-methylation of pseudouridine at position 54  in tRNAs ### SEQUENCE -M-S-L-Y-V-V-I-S-P-T-G-R-T-D-G-N-I-P-A-R-G-Y-A-G-P-S-G-R-L-D-V-I-A-R-A-Y-N-A-I-L-E-P-N-A-T-L-A-A-L-L-M-G-G-P-L-P-P-R-L-L-I-A-P-L-S-C-K-D-I-V-R-S-E-R-S-F-M-I-E-A-S-R-A-L-R-G-R-R-S-C-F-T-V-N-D-E-G-V-E-A-L-A-S-L-L-R-R-F-K-P-R-I-L-L-A-E-K-G-G-D-I-S-S-H-W-G-E-M-C-S-S-S-P-T-F-I-A-G-S-H-L-D-P-P-H-G-L-I-K-H-L-E-R-S-L-G-G-F-L-R-V-S-V-G-P-L-S-L-H-T-D-H-V-F-L-L-V-S-A-L-R-L-P-M-H-A-T-S-I-E-H-H


### FUNCTION Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP ### SEQUENCE -M-V-F-L-R-E-K-E-G-P-S-G-G-S-G-R-R-I-I-L-W-P-A-Y-F-D-S-T-L-P-R-R-L-G-R-R-V-P-R-D-M-G-V-P-S-P-K-P-E-D-V-A-E-A-A-R-R-A-G-F-E-A-V-V-E-E-S-S-Y-P-R-L-W-W-R-V-R-R-R-I-V-V-L-A-P-E-D-V-S-K-T-D-I-I-K-A-V-A-T-E-L-R-K-I-A-A-A-R-R-K-R-S


### FUNCTION Involved in protein export The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex ### SEQUENCE -M-S-V-R-R-R-R-E-R-R-A-T-P-V-T-A-A-G-L-L-S-F-Y-E-E-Y-E-G-K-I-K-I-S-P-T-I-V-V-G-A-A-I-L-V-S-A-V-V-A-A-A-H-I-F-L-P-A-V-P


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-G-K-G-T-P-S-M-G-K-H-G-R-S-K-T-H-I-V-C-R-R-C-G-R-R-S-Y-N-V-A-K-G-Y-C-A-A-C-G-F-G-R-S-R-R-M-R-R-Y-S-W-Q-N-K-K-W-N-R-V-R-V-V


### FUNCTION A probable chromatin protein, binds double-strand DNA without sequence specificity Constrains negative DNA supercoils ### SEQUENCE -M-S-Q-K-Q-L-P-P-V-K-V-R-D-P-T-T-G-K-E-V-E-L-T-P-I-K-V-W-K-L-S-P-R-G-R-R-G-V-K-I-G-L-F-K-S-P-E-T-G-K-Y-F-R-A-K-V-P-D-D-Y-P-E-T-G


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-K-F-P-K-R-I-R-T-Y-C-P-R-C-N-T-H-T-E-H-R-V-A-Q-Y-R-A-G-K-R-R-A-M-A-L-G-E-R-R-Y-R-R-K-Q-E-G-Y-G-S-Q-R-R-P-E-Q-K-R-F-A-K-V-T-K-K-Q-V-L-V-I-T-C-T-V-C-G-R-K-R-P-F-L-G-I-R-L-K-R-L-E-L-V-D-V-V-R


### FUNCTION Catalyzes the formation of CDP-2,3-bis- and CTP This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids ### SEQUENCE -M-A-L-E-L-A-V-D-W-R-I-D-N-I-L-E-A-I-I-L-M-L-P-A-M-I-A-N-A-T-P-V-V-A-G-G-R-R-P-V-D-M-G-V-V-L-P-D-G-R-R-L-L-G-D-G-K-T-I-E-G-L-L-A-G-F-A-A-G-S-A-A-G-V-L-A-A-L-A-S-G-N-M-L-L-A-V-H-S-P-A-I-A-L-G-A-L-A-G-D-M-A-G-S-F-V-K-R-R-L-G-I-E-R-G-R-P-A-P-L-L-D-Q-L-D-F-Y-L-G-A-L-A-V-S-I-A-L-G-Y-T-W-T-P-R-V-A-V-E-A-A-A-A-V-L-L-L-H-L-A-A-N-I-T-A-Y-L-L-G-L-K-K-V-P-W


### FUNCTION Produces ATP from ADP in the presence of a proton gradient across the membrane ### SEQUENCE -M-A-K-V-Q-G-D-P-R-R-F-A-D-T-V-L-E-K-P-F-K-E-A-L-A-R-V-E-E-A-R-E-A-G-L-K-L-V-E-E-A-Y-K-S-A-L-S-A-A-R-K-R-L-E-S-R-V-E-E-A-R-E-R-L-Q-G-L-K-S-K-A-D-L-E-V-R-T-E-A-E-R-V-K-D-E-L-V-S-R-L-I-E-E-A-L-A-E-F-R-R-R-K-A-G-M-E-S-Y-R-Q-Y-L-E-R-V-L-G-S-A-A-G-E-S-G-G-S-V-A-K-V-L-C-A-P-E-D-E-E-I-V-R-E-V-L-G-K-L-G-L-D-G-V-S-V-E-A-V-E-G-I-Y-G-G-V-V-V-E-L-A-E-G-A-R-L-D-Y-T-V-N-N-I-I-A-A-E-E-P-R-L-R-R-A-V-K-R-A-L-F-E-A


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-A-F-E-M-R-P-E-W-K-K-F-R-Y-R-G-R-T-L-E-E-L-L-K-M-D-I-E-E-L-A-R-L-F-P-A-R-Q-R-R-S-L-L-R-G-L-T-P-A-Q-Q-K-L-L-L-K-V-R-K-I-R-R-R-L-E-E-G-R-L-K-R-P-P-V-I-R-T-H-V-R-D-M-V-I-L-P-E-M-V-G-L-T-I-A-V-Y-N-G-K-E-F-I-P-V-K-I-V-P-E-M-I-G-H-Y-L-G-E-F-S-P-T-T-R-I-V-Q-H-G-E-P-G-L-K-A-T-R-S-S-L-H-V-A-S-K


### FUNCTION This protein binds specifically to 23S rRNA It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome ### SEQUENCE -M-P-R-W-G-Y-S-V-K-L-R-D-E-S-E-V-A-K-A-V-L-R-N-V-P-V-H-P-K-I-M-A-E-V-A-R-A-I-S-G-M-R-V-D-E-A-R-R-Y-L-R-A-V-I-E-K-R-E-A-V-P-F-R-R-A-H-G-K-Q-A-H-R-R-G-L-A-D-K-W-G-W-P-V-G-R-Y-P-V-K-A-A-R-Y-M-L-K-L-L-D-N-V-E-A-N-A-A-N-K-N-L-D-V-E-R-L-K-I-I-H-V-A-A-H-K-G-I-T-L-K-R-W-M-P-R-A-W-G-R-A-T-P-R-N-R-V-H-S-H-I-E-I-M-V-R-E-V


### FUNCTION Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends ### SEQUENCE -M-K-G-R-R-P-S-H-R-R-Q-L-I-P-P-L-L-T-G-L-R-V-K-V-L-A-H-S-D-P-S-L-E-G-L-E-G-W-V-V-V-E-E-A-R-S-L-R-I-L-T-L-E-G-R-V-S-T-V-L-K-D-L-A-V-I-E-V-E-A-P-G-G-E-Y-I-R-I-S-G-R-V-L-I-G-N-P-L-D-R-V-K-E-Y-R-W-R-V-S-R-R-C-R-S-S-S-R-L-K-T


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-P-K-F-K-Q-V-K-N-L-K-I-P-G-V-E-P-P-E-K-V-C-S-D-P-N-C-P-W-H-G-T-L-R-V-R-G-V-L-L-E-G-V-V-A-K-A-R-A-R-R-M-V-V-V-Q-H-V-Y-L-Y-Y-D-K-K-Y-N-R-Y-E-R-R-S-K-K-I-H-A-H-L-P-D-C-I-S-V-K-E-G-D-V-V-V-I-G-E-T-M-P-I-S-K-T-V-K-F-T-V-L-G-V-K-R-R


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-A-K-K-K-K-Y-G-V-V-V-S-R-Y-G-V-N-T-G-L-Q-V-G-S-Y-V-P-V-A-D-N-S-G-A-K-E-V-M-I-I-S-V-P-Q-V-K-T-R-L-R-R-L-P-S-A-G-V-G-D-L-V-V-V-S-V-K-K-G-T-P-Q-M-R-R-Q-V-V-Y-A-V-V-V-R-Q-R-R-P-F-R-R-P-D-G-T-W-V-S-F-E-D-N-A-V-V-I-V-N-P-D-G-T-P-R-G-S-E-V-R-G-P-I-A-R-E-A-A-E-R-W-P-R-V-A-K-I-A-T-M-I-V


### FUNCTION One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit ### SEQUENCE -M-P-V-L-T-R-S-R-Q-P-R-K-Q-R-R-A-L-Y-R-A-P-L-H-A-R-Q-K-L-V-S-A-T-L-S-P-E-L-R-E-K-Y-G-V-R-S-L-P-V-R-K-G-D-K-V-R-V-M-R-G-D-F-K-G-H-E-G-K-V-V-K-V-D-L-R-R-L-R-I-Y-I-D-G-V-T-V-T-K-A-D-G-T-P-V-F-R-P-I-H-P-S-N-V-M-I-V-E-L-D-L-S-D-E-Y-R-K-K-M-I-E-R-R-A-A-G-R-R-G-G-G-N-S-E


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-S-A-K-A-Q-S-L-P-I-P-P-E-R-V-S-E-I-L-D-E-W-K-R-S-P-M-R-R-P-R-I-V-K-V-T-V-N-I-S-I-G-Q-S-G-E-R-L-Q-R-A-A-E-V-L-E-E-L-T-G-Q-K-P-V-F-R-K-A-K-R-T-I-R-A-F-G-V-R-K-G-E-N-I-A-V-M-V-T-L-R-G-E-K-A-L-N-F-L-K-R-A-L-D-A-V-G-H-R-I-K-T-S-S-I-D-E-H-G-N-V-S-F-G-I-E-E-H-I-L-I-P-G-V-K-Y-D-P-R-V-G-I-L-G-M-D-V-A-I-T-I-Q-R-P-G-H-R-I-V-E-R-R-R-Q-R-R-G-H-I-P-R-R-H-R-V-T-R-E-E-T-M-V-L-L-N-Q-L-F-G-V-T-F-V


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-V-M-L-D-T-L-A-N-A-M-A-A-I-K-N-A-E-M-R-G-K-G-E-A-I-I-M-P-S-S-K-L-I-A-N-V-L-R-I-L-E-K-E-G-Y-I-G-G-F-E-Y-I-D-D-G-R-W-G-K-F-R-V-K-L-L-G-R-I-N-D-I-G-V-V-K-P-R-T-P-V-S-Y-R-E-L-A-K-M-P-E-H-L-R-K-Y-L-A-S-R-D-V-G-L-L-I-L-S-T-P-Q-G-V-M-T-H-R-E-A-L-K-R-K-I-G-G-I-V-I-A-Y-V-Y


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-A-K-D-V-H-V-V-E-R-V-E-V-P-E-G-V-T-V-S-I-D-G-M-R-V-K-V-S-G-P-K-G-E-V-E-R-D-F-S-H-A-R-G-V-L-I-R-L-E-D-N-S-V-V-V-E-S-F-F-A-K-A-R-Q-R-A-L-V-G-A-I-A-G-H-I-R-N-M-I-K-G-V-Q-G-G-F-R-Y-K-L-K-I-M-Y-S-H-F-P-I-N-V-K-V-E-G-D-K-F-I-I-S-N-F-L-G-E-K-G-L-R-I-A-R-I-M-P-G-V-K-V-Q-V-K-G-S-D-V-I-V-E-G-I-D-V-E-K-V-A-Q-T-A-A-N-I-E-L-A-T-K-V-K-D-K-D-R-R-K-F-M-D-G-I-Y-I-Y-E-R-E-V-I-A


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-D-Y-R-F-Q-R-R-L-A-A-E-I-L-G-V-G-E-S-R-I-W-I-S-P-D-P-E-L-R-E-E-I-E-G-A-V-T-K-A-D-V-R-A-L-I-K-R-G-V-I-K-V-L-P-E-K-G-N-A-G-H-A-S-K-V-R-H-L-Q-R-R-K-G-R-R-R-G-M-G-R-R-K-G-V-A-T-A-R-L-D-P-K-E-R-W-M-H-R-I-R-K-I-R-R-Y-L-R-Y-L-R-D-K-Q-V-I-D-R-K-T-Y-R-R-L-Y-M-L-A-K-G-G-T-F-R-D-L-A-S-L-K-R-Y-M-A-D-R-G-L-V-P-E-E-K-I-R


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-V-V-R-R-R-K-K-S-R-K-L-R-G-R-T-R-T-M-S-W-G-R-I-G-Q-H-R-K-S-G-S-K-G-G-Y-G-A-A-G-L-G-K-H-E-W-T-W-T-I-K-Y-A-P-T-W-Y-G-K-K-G-F-N-P-P-R-I-R-A-G-L-E-V-T-T-I-N-V-G-Q-L-D-E-I-A-A-L-L-E-A-Q-G-K-A-E-K-E-D-G-K-I-V-V-N-L-E-K-L-G-I-H-K-L-L-G-E-G-R-V-A-R-P-L-K-V-I-T-P-L-A-S-E-L-A-I-K-K-I-E-E-A-G-G-E-V-I-V-T-R-A-T-R-E-E-A-E-E-S


### FUNCTION Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A ### SEQUENCE -M-S-V-A-L-S-I-P-L-L-S-L-P-E-D-M-R-E-A-L-A-A-A-A-G-P-V-Y-S-G-D-R-F-R-R-Q-L-L-Q-T-P-C-S-G-V-A-C-I-G-D-Y-V-S-Q-A-C-I-A-T-L-S-T-A-W-T-G-P-L-I-L-V-V-D-G-K-T-R-R-E-S-W-R-D-M-V-V-P-Q-G-F-R-V-H-R-V-R-S-P-P-G-S-L-S-L-E-A-Y-T-T-I-C-K-L-M-E-E-Y-G-R-H-V-V-F-V-E-G-E-E-D-L-I-A-L-A-A-L-D-C-G-I-D-W-T-V-V-Y-G-L-P-G-V-G-G-V-V-V-H-R-C-L-R-K-P-G-L-E-N-S-S-V-L-A-F-K-P-G-T-G-V-H-H-Q-S-S-P


### FUNCTION Binds to 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome ### SEQUENCE -M-K-P-E-E-V-I-I-R-V-Y-V-T-E-K-T-T-R-M-L-E-E-E-N-T-L-T-F-I-V-R-R-E-A-T-K-N-D-V-K-R-A-V-E-Q-L-F-G-V-K-V-E-K-V-R-T-L-I-T-P-R-G-Y-K-K-A-Y-V-K-L-A-P-E-Y-K-A-L-D-V-A-T-K-L-G-A-V


### FUNCTION Contacts the emerging nascent chain on the ribosome ### SEQUENCE -M-L-P-V-N-P-R-D-L-E-K-M-M-R-R-L-G-I-K-V-E-Q-L-S-A-D-E-A-R-I-V-L-G-S-G-E-T-M-V-F-R-S-P-T-V-I-V-M-R-A-K-G-Q-P-P-M-V-Y-L-V-G-D-Y-T-V-E-K-P-R-E-E-T-A-A-E-I-T-E-E-D-V-A-L-V-A-E-Q-A-G-V-S-M-E-E-A-R-K-A-L-E-E-S-G-G-D-I-A-E-A-I-L-R-L-K-G-E-E


### FUNCTION Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently ### SEQUENCE -M-Q-C-G-G-W-M-H-E-E-H-T-A-D-V-L-V-I-A-Y-G-R-T-L-E-E-A-F-E-N-A-A-R-G-V-Y-E-V-V-T-D-T-S-R-V-E-P-R-R-R-V-D-A-S-I-E-G-I-D-L-E-N-L-L-Y-R-F-I-E-N-L-I-A-Y-T-D-S-E-G-L-V-F-G-L-F-R-V-C-K-I-E-C-N-G-E-S-C-S-I-V-A-S-A-W-G-E-E-F-D-P-S-R-H-E-H-R-T-I-V-K-A-M-T-Y-A-D-M-E-I-K-E-E-N-G-C-W-R-V-Q-F-V-V-D-I


### FUNCTION Probable zinc metalloprotease whose natural substrate is unknown ### SEQUENCE -M-E-S-S-L-T-F-L-L-L-P-V-G-F-P-G-E-V-L-V-T-L-A-R-R-A-R-E-A-M-P-V-P-S-L-W-L-A-S-T-D-P-L-E-P-P-I-E-A-Y-S-W-E-R-M-Q-F-D-A-E-K-V-N-E-H-I-H-S-V-L-Y-D-Y-V-R-E-G-I-R-I-I-G-V-V-D-A-D-G-Y-I-P-G-F-N-F-V-F-G-L-A-S-T-A-L-G-V-A-T-V-Y-T-R-R-L-K-T-G-G-N-G-L-Y-T-E-R-L-L-K-E-V-L-H-E-A-G-H-L-L-G-L-D-H-C-S-N-R-E-C-V-M-S-F-S-R-S-V-E-E-V-D-R-K-A-P-L-F-C-S-S-C-K-A-K-L-V-L-K-Y-G-S-R-G-Q


### FUNCTION This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA ### SEQUENCE -M-F-L-S-G-R-D-L-V-L-L-G-V-V-K-G-H-S-N-G-A-I-Q-P-A-G-V-D-L-S-V-G-E-I-E-S-L-A-D-A-G-F-L-G-E-E-D-K-I-M-P-K-G-D-R-I-Q-C-E-Y-G-V-C-E-L-E-P-G-A-Y-R-L-R-F-N-E-V-V-S-I-P-P-G-H-V-G-F-C-F-P-R-S-S-L-L-R-M-G-C-Y-L-G-C-A-V-W-D-P-G-Y-T-G-R-G-Q-A-M-L-L-V-A-N-P-H-G-L-R-L-E-M-G-S-R-I-A-Q-L-V-V-A-R-V-E-G-P-L-T-S-L-Y-K-G-D-Y-Q-G-E-G-L


### FUNCTION Acts as a methyl group carrier between MtbB and MtbA ### SEQUENCE -T-L-Q-G-Q-K-D-V-I-E-L-L-K-E-E-G-L-R-D-K-I-K-V-M-V-G-G-A-P-A-T-Q-A-W-A-D-K-I-G-A-D-C-Y-A-E-N-A-S-E-A-V-A-K-A-K-E-L-L-A


### FUNCTION Binds to muscle nicotinic acetylcholine receptor  and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission ### SEQUENCE -M-K-T-L-L-L-T-L-V-V-V-T-I-V-C-L-D-L-G-Y-T-R-R-C-F-N-H-P-S-S-Q-P-Q-T-N-K-S-C-P-P-G-E-N-S-C-Y-N-K-Q-W-R-D-H-R-G-T-I-I-E-R-G-C-G-C-P-T-V-K-P-G-I-K-L-T-C-C-Q-S-E-D-C-N-N


### FUNCTION Binds to muscle nicotinic acetylcholine receptor  and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission ### SEQUENCE -M-K-T-L-L-L-T-L-V-V-V-T-I-V-C-L-D-L-G-Y-T-R-R-C-F-N-H-P-S-S-Q-P-Q-T-N-K-S-C-P-P-G-E-N-S-C-Y-N-K-Q-W-R-D-H-R-G-T-I-T-E-R-G-C-G-C-P-T-V-K-P-G-I-K-L-T-C-C-Q-S-E-D-C-N-N


### FUNCTION Binds to muscle nicotinic acetylcholine receptor  and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission ### SEQUENCE -M-K-T-L-L-L-T-L-V-V-V-T-M-V-C-L-D-L-G-Y-T-R-R-C-F-N-Q-Q-S-S-Q-P-K-T-T-K-S-C-P-L-G-E-N-S-C-Y-N-K-Q-W-R-D-H-R-G-S-I-T-E-R-G-C-G-C-P-K-V-K-P-G-I-K-L-R-C-C-E-S-E-D-C-N-N


### FUNCTION Somatostatin inhibits the release of somatotropin ### SEQUENCE -M-Q-L-L-S-S-L-V-S-L-L-L-V-L-Y-S-V-R-A-A-A-V-L-P-V-E-E-R-N-P-A-Q-S-R-E-L-S-K-E-R-K-E-L-I-L-K-L-I-S-G-L-L-D-G-V-D-N-S-V-L-D-G-E-I-A-P-V-P-F-D-A-E-E-P-L-E-S-R-L-E-E-R-A-V-Y-N-R-L-S-Q-L-P-Q-R-D-R-K-A-P-C-K-N-F-F-W-K-T-F-T-S-C


### FUNCTION Somatostatin inhibits the release of somatotropin ### SEQUENCE -M-L-S-T-R-I-Q-C-A-L-A-L-L-S-L-A-L-A-V-C-S-V-S-A-A-P-T-D-A-K-L-R-Q-L-L-Q-R-S-L-L-N-P-A-G-K-Q-E-L-A-R-Y-T-L-A-D-L-L-S-E-L-V-Q-A-E-N-E-A-L-E-P-E-D-L-S-R-A-V-E-K-D-E-V-R-L-E-L-E-R-A-A-G-P-M-L-A-P-R-E-R-K-A-G-C-K-N-F-F-W-K-T-F-T-S-C


### FUNCTION Exhibits M2 muscarinic acetylcholine receptor -blocking activity, but has a weak binding activity toward nicotinic AChR Moreover, it inhibits collagen-induced platelet aggregation ### SEQUENCE -M-K-T-L-L-L-S-L-V-V-V-I-I-V-C-L-D-L-G-Y-T-M-Q-C-K-T-C-S-F-Y-T-C-P-N-S-E-T-C-P-D-G-K-N-I-C-V-K-R-S-W-T-A-V-R-G-D-G-P-K-R-E-I-R-R-E-C-A-A-T-C-P-P-S-K-L-G-L-T-V-F-C-C-T-T-D-N-C-Y-H


### FUNCTION Binds with low affinity to muscular ### SEQUENCE -M-K-T-L-L-L-T-L-V-V-V-T-I-V-C-L-D-L-G-Y-T-L-T-C-L-I-C-P-E-K-Y-C-N-K-V-H-T-C-L-N-G-E-K-I-C-F-K-K-Y-D-Q-R-K-L-L-G-K-G-Y-I-R-G-C-A-D-T-C-P-K-L-Q-N-R-D-V-I-F-C-C-S-T-D-K-C-N-L


### FUNCTION Binds with low affinity to muscular ### SEQUENCE -M-K-T-L-L-L-S-L-V-V-V-T-I-V-C-L-D-L-G-Y-T-L-T-C-L-I-C-P-E-K-Y-C-N-K-V-H-T-C-L-N-G-E-K-I-C-F-K-K-Y-D-Q-R-K-L-L-G-K-R-Y-I-R-G-C-A-D-T-C-P-V-R-K-P-R-E-I-V-E-C-C-S-T-D-K-C-N-H


### FUNCTION Binds to muscle nicotinic acetylcholine receptor  and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission ### SEQUENCE -M-K-T-L-L-L-T-L-L-V-V-T-I-V-C-L-D-L-G-Y-T-L-E-C-H-N-Q-Q-S-S-Q-A-P-T-T-T-G-C-S-G-G-E-T-N-C-Y-K-K-S-W-R-D-H-R-G-Y-R-I-E-R-G-C-G-C-P-S-V-K-K-G-I-E-I-N-C-C-T-T-D-R-C-N-N


### FUNCTION Binds to muscle nicotinic acetylcholine receptor  and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission ### SEQUENCE -M-K-T-L-L-L-T-L-L-V-V-T-I-V-C-L-D-L-G-Y-T-L-E-C-H-N-Q-Q-S-S-E-T-P-T-T-T-G-C-S-G-G-E-T-N-C-Y-K-K-S-W-R-D-H-R-G-Y-R-I-E-R-G-C-G-C-P-S-V-K-K-G-I-E-I-N-C-C-T-T-D-R-C-N-N


### FUNCTION May act as a scaffolding protein within caveolar membranes Interacts directly with G-protein alpha subunits and can functionally regulate their activity ### SEQUENCE -M-G-L-E-K-E-K-L-E-C-S-I-I-M-D-E-D-E-F-N-R-S-I-E-P-I-L-S-K-K-A-R-L-Y-S-S-A-P-D-R-D-P-H-D-I-N-A-Q-L-K-V-G-F-E-D-V-I-A-E-P-A-S-A-H-S-F-D-R-V-W-I-G-S-S-A-T-F-E-L-V-K-F-I-F-Y-R-L-L-T-T-L-L-A-V-P-A-A-F-I-L-G-V-V-F-G-V-L-S-C-I-H-I-W-L-V-M-P-V-T-R-S-F-L-M-L-L-P-S-I-Q-V-V-W-K-S-V-T-D-M-F-I-T-P-L-F-H-S-M-G-R-S-L-S-S-I-Q-V-R-T-S-D-T


### FUNCTION Binds to muscle nicotinic acetylcholine receptor  and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission ### SEQUENCE -M-K-T-L-L-L-T-L-V-V-V-T-I-V-C-L-D-L-G-Y-T-R-R-C-F-N-Q-Q-S-S-E-P-Q-T-N-K-S-C-P-P-G-E-N-S-C-Y-N-K-Q-W-R-D-H-R-G-T-I-I-E-R-G-C-G-C-P-Q-V-K-S-G-I-K-L-T-C-C-Q-S-D-D-C-N-N


### FUNCTION Binds to muscle nicotinic acetylcholine receptor  and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission ### SEQUENCE -M-K-T-L-L-L-T-L-V-V-V-T-I-V-C-L-D-L-G-Y-T-R-R-C-F-N-Q-Q-S-S-E-P-Q-T-N-K-S-C-P-P-G-E-N-S-C-Y-N-K-Q-W-R-D-H-R-G-T-I-T-E-R-G-C-G-C-P-Q-V-K-S-G-I-K-L-T-C-C-Q-S-D-D-C-N-N


### FUNCTION Binds to muscle nicotinic acetylcholine receptor  and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission ### SEQUENCE -M-K-T-L-L-L-T-L-V-V-V-T-T-V-C-L-D-L-G-Y-T-R-R-C-F-N-Q-Q-S-S-Q-P-K-T-T-K-S-C-P-L-G-E-N-S-C-Y-N-K-Q-W-R-D-H-R-G-S-I-T-E-R-G-C-G-C-P-K-V-K-P-G-I-K-L-R-C-C-E-S-E-D-C-N-N


### FUNCTION Binds to muscle nicotinic acetylcholine receptor  and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission ### SEQUENCE -M-K-T-L-L-L-T-L-V-V-V-T-I-V-C-L-D-L-G-Y-T-R-R-C-F-N-Q-Q-S-S-E-P-Q-T-N-K-S-C-P-P-G-E-N-S-C-Y-R-K-Q-W-R-D-H-R-G-T-I-I-E-R-G-C-G-C-P-T-V-K-P-G-I-K-L-R-C-C-E-S-E-D-C-N-N


### FUNCTION Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX ### SEQUENCE -R-K-L-A-F-R-Y-R-R-V-K-E-L-Y-N-T-Y-K-N-N-I-G-G-L-L-G-P-A-K-R-D-A-W-L-Q-L-R-A-E-I-E-A-L-T-D-S-W-L-T-N-A-L-K-S-L-S-I-I-S-T-R-S-N-C-V-N-V-L-V-T-T-T-Q-L-I-P-A-L-A-K-V-L-L-Y-S-L-G-G-A-F-P-I-E-N-I-Y-S-A-T-K-I-G-K-E-S-C-F-E-R-I-V-S-R-F-G-T-N-I-T


### FUNCTION Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX ### SEQUENCE -R-K-L-A-F-R-Y-R-R-V-K-E-L-Y-T-T-Y-K-N-N-V-G-G-L-L-G-P-A-K-R-D-A-W-L-Q-L-R-A-E-V-E-A-L-T-D-S-W-L-T-H-A-L-K-S-L-S-I-I-S-S-R-S-N-C-V-N-V-L-V-T-T-T-Q-L-I-P-A-L-A-K-V-L-L-Y-S-L-G-A-V-F-P-I-E-N-I-Y-S-A-T-K-I-G-K-E-S-C-F-E-R-I-V-S-R-F-G-T-N-I-T


### FUNCTION Plays an essential role in viral DNA replication ### SEQUENCE -M-T-N-V-W-F-A-T-D-V-N-L-I-N-C-V-L-K-D-N-L-F-L-I-D-N-N-Y-I-I-L-N-V-F-D-Q-E-T-D-Q-V-R-P-L-C-L-G-E-I-N-A-L-Q-T-D-A-A-A-Q-A-D-A-M-L-D-T-S-S-T-S-E-L-Q-S-N-A-S-T


### FUNCTION Involved in late/very late gene activation ### SEQUENCE -M-A-P-A-V-V-G-A-S-Q-L-R-G-G-D-S-P-G-P-A-R-N-R-D-H-C-L-N-R-S-E-V-Y-A-L-T-R-E-A-I-N-K-R-K-H-L-G-D-V-K-G-V-C-A-H-L-F-D-D-S-F-S-A-Q-S-D-Y-I-R-E-N-L-A-T-A-F-I-V-V-G-D-N-C-R-E-R-K-H-L-G-Q-H-A-A-R-F-D-R-V-F-S-L-K-R-R-T-L-Y-D-E-Y-H-A-S-A-G-R-Y-G-D-T-K-P-C-R-K-R-R-F-S-R-A-A-Q-V-R-D-Q-P-A-Q-Q-E-R-L-G-D-Q-S-V-Q-D-S-P-L-R-K-E-K-D-L-V-P-H-Q-G-V-G-G-V-R-P-G-Q-E-N-G-Q-A-R-Q-E-E-Q-S-Q-Q


### FUNCTION Capsid protein self-assembles to form a quasi-spherical capsid, about 26 nm, or bacilliform ### SEQUENCE -M-S-S-A-A-Q-P-M-S-R-R-A-R-R-R-A-A-R-R-A-L-G-S-Q-P-G-T-S-G-G-M-V-I-P-V-S-F-V-V-S-G-A-T-S-A-D-F-V-T-Y-H-S-L-Y-S-R-L-A-A-Y-N-G-D-L-W-I-R-R-V-A-V-R-V-T-G-S-V-A-K-R-M-G-K-Y-A-F-F-E-G-L-A-V-D-K-S-Q-I-L-S-A-A-H-A-R-P-Y-V-Y-G-L-P-S-T-L-S-L-P-G-G-R-R-Q-V-K-D-F-Q-S-I-N-L-F-F-L-L-D-G-T-A-H-A-G-E-F-A-A-G-T-F-Y-F-E-F-E-G-S-P-N-V-D-F-P-R-D-S-E-G-S-N-Q-A-V-E-K-F-Y-L-E-H-I-N-A


### FUNCTION Pathogenicity determinant , a mechanism of plant viral defense that limits the accumulation of viral RNAs ### SEQUENCE -M-K-M-E-N-L-I-S-M-F-C-F-S-S-K-G-S-S-K-R-R-T-K-G-S-S-T-W-F-P-Q-P-D-Q-H-I-T-I-R-T-F-R-R-L-K-A-H-Q-M-L-S-H-T-W-T-K-T-E-T-S-L-T-M-E-V-S-K-S-M-A-D-Q-L-E-E-V-N-S-L-P-T-T-L-M-P-R-H-S-I-V-D-P-S-Y-R-P-S-I-Y


### FUNCTION Increases viral DNA accumulation Enhances infectivity and symptom expression ### SEQUENCE -M-D-F-R-T-G-D-N-I-T-A-A-Q-L-K-N-G-V-F-I-W-E-V-R-N-P-L-S-F-K-I-M-Q-H-R-Q-I-R-P-G-S-Q-M-Y-V-T-Q-I-R-I-M-F-N-H-G-L-K-K-A-L-L-M-H-K-C-F-L-D-L-T-L-Y-H-Y-L-T-A-T-S-G-M-I-L-S-T-F-S-D-Q-L-F-R-Y-L-N-N-L-G-V-I-S-I-G-N-V-L-K-G-A-S-H-I-L-Y-E-K-L-H-H-V-E-D-V-S-L-T-H-N-V-Q-Y-K-L-Y


### FUNCTION Through its interaction with host SGS3, acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing , a mechanism of plant viral defense that limits the accumulation of viral RNAs ### SEQUENCE -M-W-D-P-L-V-N-D-F-P-K-S-L-H-G-F-R-C-M-L-A-I-K-Y-L-Q-Y-I-Q-E-N-Y-P-S-N-S-L-G-F-V-Y-L-T-E-L-I-Q-V-L-R-I-R-K-H-A-K-A-E-L-R-Y-R-L-L-Y-P-D-V-E-C-A-E-E-A-D-L-R-H-P-A-F-L-T-C-H-C-G-K-C-P-C-Q-R-E-K-E-E-V-D-Q-P-T-H-V-E-E-T-E-I-L-S-V-I-P-L-S


### FUNCTION This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA ### SEQUENCE -M-S-F-D-S-G-C-P-P-T-P-P-V-K-L-L-F-K-K-H-S-P-F-A-V-T-P-Q-R-A-T-S-G-A-A-G-Y-D-L-C-S-S-A-D-V-V-V-P-P-K-S-R-S-L-I-P-T-D-L-S-F-Q-F-P-R-G-V-Y-G-R-I-A-P-R-S-G-L-A-V-K-F-F-I-D-V-G-A-G-V-I-D-S-D-Y-R-G-I-V-S-V-L-L-F-N-F-S-D-H-N-F-N-V-R-R-G-D-R-I-A-Q-L-I-L-E-R-H-L-T-P-D-L-E-E-R-S-G-L-D-E-T-A-R-G-A-A-G-F-G-S-T-G-G-F-D-T-G-V-C-P-S-S-F-S


### FUNCTION May transport viral genome to neighboring plant cells directly through plasmosdesmata, without any budding The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier ### SEQUENCE -M-A-D-P-V-Y-Y-Q-G-Y-Q-D-D-G-D-I-D-A-Q-K-R-H-Q-A-L-Y-L-I-G-I-I-I-L-I-M-V-C-I-I-I-L-W-V-C-I-M-L-A-C-Y-I-P-G-F-L-K-K-T-M-E-A-W-L-S-S-S-S-M-M-K-R-R-V-A-A-T-I-T-R-T-P-F-E-A-T-G-P-E-R-E-R-N-W-D-A-R-R-Q-T-N-A-A-S-S-Q-P-S-N-G-G-V-F


### FUNCTION Putative nuclear shuttle protein ### SEQUENCE -M-A-D-W-F-A-S-P-L-K-T-C-T-H-V-C-D-F-P-T-L-A-G-D-P-S-Q-E-I-T-C-C-D-S-M-K-N-K-L-N-D-S-R-K-V-L-L-V-S-C-S-V-S-F-N-G-S-F-Y-G-G-N-R-N-V-R-G-Q-L-Q-I-S-M-L-E-D-D-G-V-C-R-P-I-G-Y-V-P-I-G-G-Y-L-Y-H-N-D-Y-G-Y-Y-E-G-E-K-T-F-N-L-D-I-E-S-Q-Y-L-K-K-D-E-D-Y-N-R-K-F-I-V-S-V-L-N-E-N-G-L-D-S-L-C-D-L-K-V-F-I-V-H-A-L-R-I-K-V


### FUNCTION Interacts with and disrupts the function of host retinoblastoma-related proteins RBR, which are key regulators of the cell cycle Induces transcriptional activation of E2F-regulated S-phase and G2/M-phase-specific genes Inactivation of the ability of RBR to arrest the cell cycle leads to the stimulation of viral DNA replication ### SEQUENCE -M-G-L-K-Y-F-A-H-L-P-L-E-L-R-E-K-I-V-R-D-H-L-Q-E-E-R-K-K-E-F-L-E-K-A-I-E-D-S-C-R-R-H-E-A-L-L-I-E-D-P-S-P-A-E-L-N-S-L-S-K-F-L-T-A-L-S-D-Y-V-G-N-Q-F-N-T-R-C-L-I-R-W-K-K-D-V-P-S-K-V-K-F-G-F-M-D-E-Q-H-H-K-L-Y-G-S-M-D-M-D-D-L-S-C-G-E-L-F-I-P-D-E-E-D-D-L-T-Y-E-D-G-V-I-V-R-C-S-Q-L-D-Q-L-F-K-S-L-G-I-E-I-V-Y-I-V-V-S-K-H-C-I-W-A-P-L-S-K-E-I-V-I-K


### FUNCTION In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins ### SEQUENCE -M-C-H-T-S-C-S-S-G-C-Q-P-S-C-C-V-S-S-S-C-Q-P-S-C-C-V-S-S-P-C-Q-A-S-C-F-V-S-S-P-C-Q-P-S-C-C-V-S-S-S-C-Q-S-A-C-C-R-P-A-I-C-I-P-V-R-Y-Q-V-A-C-C-V-P-V-S-C-G-P-T-V-C-M-A-P-S-C-Q-S-S-V-C-V-P-V-S-C-R-P-V-C-V-T-S-S-C-Q-S-S-G-C-C-Q-P-S-C-P-T-L-V-C-K-P-V-T-C-S-N-P-S-C-C


### FUNCTION Involved in urease metallocenter assembly Binds nickel Probably functions as a nickel donor during metallocenter assembly ### SEQUENCE -M-I-I-E-S-I-S-G-N-I-H-D-L-P-G-E-D-L-E-D-V-H-V-E-S-V-V-L-P-L-A-D-L-T-K-R-I-Q-R-V-R-S-D-H-G-T-E-L-G-I-R-L-A-P-G-A-P-D-L-R-E-G-D-I-L-L-R-N-E-R-G-I-V-V-V-R-L-E-P-T-D-V-L-V-I-A-P-V-T-V-R-E-M-G-V-V-A-H-N-L-G-N-R-H-L-P-A-Q-F-F-G-P-A-E-P-F-P-G-L-E-G-H-D-G-V-M-V-I-Q-Y-D-H-T-A-E-H-Y-L-E-H-L-G-V-R-H-A-R-M-E-R-S-M-P-V-P-F-R-H-A-E-H-T-H


### FUNCTION Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA In the 70S ribosome it contacts the 23S rRNA , connecting the 2 subunits ### SEQUENCE -M-A-R-I-A-G-V-N-L-P-A-Q-K-H-V-W-V-G-L-Q-S-I-Y-G-I-G-R-T-R-S-K-K-L-C-E-S-A-G-V-T-S-T-T-K-I-R-D-L-S-E-P-E-I-E-R-L-R-A-E-V-G-K-Y-V-V-E-G-D-L-R-R-E-I-G-I-A-I-K-R-L-M-D-L-G-C-Y-R-G-L-R-H-R-R-G-H-P-L-R-G-Q-R-T-R-T-N-A-R-T-R-K-G-P-R-K-A-I-R-K


### FUNCTION Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II , cyclic electron flow around PSI, and state transitions PetG is required for either the stability or assembly of the cytochrome b6-f complex ### SEQUENCE -M-I-E-P-L-L-C-G-I-V-L-G-L-I-P-I-T-L-A-G-L-F-M-A-A-Y-L-Q-Y-R-R-G-N-Q-L-G-A


### FUNCTION This protein binds to 23S rRNA in the presence of protein L20 ### SEQUENCE -M-A-Y-A-I-I-E-A-S-G-K-Q-L-W-V-E-P-G-R-F-Y-D-L-D-R-L-D-A-D-L-D-Q-S-L-T-L-D-K-V-L-L-V-Q-D-E-G-A-P-Q-I-G-Q-P-Y-V-A-G-A-T-V-Q-V-T-V-L-S-H-P-R-G-R-K-V-T-V-Y-K-M-K-P-K-K-K-T-R-K-K-Q-G-H-R-Q-D-L-T-R-V-L-V-E-S-I-T-V-G-G-K-V-L-T-A-N-A-A-D-L-P-K-S-E-A-D-I-D-A-A-G


### FUNCTION Seems to affect the transcription of cya3 May be negatively autoregulated ### SEQUENCE -M-A-D-E-S-N-T-G-S-I-A-A-A-V-A-P-N-A-D-V-K-A-P-A-A-K-K-K-R-S-P-R-R-Q-K-A-V-A-E-P-R-R-A-V-S-E-T-P-A-A-K-P-R-R-Y-S-E-Q-Q-R-K-E-K-L-K-L-I-E-T-Q-V-T-E-G-K-V-T-L-K-D-A-I-K-S-A-G-I-S-E-Q-T-Y-Y-Q-W-K-R-T-V-K-P-V-E-Q-K-A-E-K-R-L-P-T-G-E-E-L-A-D-L-V-R-L-E-E-E-N-Q-R-L-R-K-L-L-A-E-K-L-R-A-E-N-A-D-L-R-K-R-L-G-L-D


### FUNCTION General  is transferred to the phosphoryl carrier protein HPr by enzyme I Phospho-HPr then transfers it to the PTS EIIA domain ### SEQUENCE -M-P-A-R-E-I-T-I-I-N-K-L-G-L-H-A-R-A-A-A-K-F-V-G-V-A-G-R-F-P-C-Q-V-P-V-G-R-A-P-D-K-L-V-D-G-K-S-I-M-A-V-M-M-L-A-A-G-K-G-T-Q-V-H-L-H-T-X-G-E-Q-D-S-D-A-M-D-A-L-V-E-L-I-N-N-F-F-D-E-G-E


### FUNCTION Regulates the transcription of the pyrimidine nucleotide  operon in response to exogenous pyrimidines ### SEQUENCE -M-S-L-P-N-P-A-D-L-I-R-Q-M-A-V-D-L-R-A-H-L-A-R-R-A-I-T-E-P-R-Y-I-G-I-R-T-G-G-V-W-V-A-Q-A-L-Q-E-A-M-G-D-S-S-P-M-G-T-L-D-V-S-F-Y-R-D-D-F-S-Q-N-G-L-H-P-Q-V-R-P-S-E-L-P-F-E-V-E-G-Q-H-L-V-L-V-D-D-V-L-M-S-G-R-T-I-R-A-A-L-N-E-L-F-D-Y-G-R-P-A-S-V-T-L-V-C-L-L-D-L-D-A-G-E-L-P-I-R-P-N-V-L-G-A-T-L-S-L-A-A-H-E-R-V-K-L-T-G-P-A-P-L-A-L-E-R-Q-D-L-A-S-R-S-A-L


### FUNCTION Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'--3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism ### SEQUENCE -M-E-T-L-N-F-Q-F-P-A-A-E-P-G-R-G-R-T-L-V-G-C-V-S-S-G-D-L-E-V-L-I-E-P-G-T-A-G-S-L-Q-I-Q-V-I-T-S-V-N-G-S-A-A-R-W-A-Q-L-F-Q-R-L-F-E-G-R-A-W-P-A-V-N-I-D-I-H-D-F-G-A-T-P-G-V-V-R-L-R-L-E-Q-G-F-E-E-I-A-H-D


### FUNCTION Together with the chaperonin GroEL, plays an essential role in assisting protein folding The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel ### SEQUENCE -M-A-F-K-P-L-H-D-R-V-L-V-R-R-V-Q-S-D-E-K-T-K-G-G-L-I-I-P-D-S-A-K-E-K-P-A-E-G-E-I-T-S-V-G-E-G-A-R-K-D-S-G-E-L-I-A-P-A-V-K-A-G-D-R-V-L-F-G-K-W-S-G-T-E-V-T-V-D-G-E-E-L-L-I-M-K-E-S-D-I-L-G-I-I-A


### FUNCTION Involved in protein export Participates in an early event of protein translocation ### SEQUENCE -M-A-L-T-L-Q-I-I-L-V-V-A-S-L-L-M-T-V-F-V-L-L-H-K-G-K-G-G-G-L-S-S-L-F-G-G-G-V-Q-S-N-L-S-G-S-T-V-V-E-K-N-L-D-R-V-T-I-L-V-A-V-I-W-I-V-C-I-V-A-L-N-L-I-Q-T-Y-S


### FUNCTION Component of the sil cation-efflux system that confers resistance to silver ### SEQUENCE -M-K-N-I-V-L-A-S-L-L-G-F-G-L-I-S-S-A-W-A-T-E-T-V-N-I-H-E-R-V-N-N-A-Q-A-P-A-H-Q-M-Q-S-A-A-A-P-V-G-I-Q-G-T-A-P-R-M-A-G-M-D-Q-H-E-Q-A-I-I-A-H-E-T-M-T-N-G-S-A-D-A-H-Q-K-M-V-E-S-H-Q-R-M-M-G-S-Q-T-V-S-P-T-G-P-S-K-S-L-A-A-M-N-E-H-E-R-A-A-V-A-H-E-F-M-N-N-G-Q-S-G-P-H-Q-A-M-A-E-A-H-R-R-M-L-S-A-G


### FUNCTION Involved in protein export Participates in an early event of protein translocation ### SEQUENCE -M-V-A-C-C-H-R-A-P-V-V-H-R-R-S-S-E-S-E-E-V-G-P-A-V-V-L-G-F-S-I-A-L-I-V-F-S-L-L-L-M-L-L-V-L-M-H-K-G-K-G-G-G-L-S-D-M-F-G-G-G-M-Q-S-S-V-G-G-S-S-V-A-E-R-N-L-D-R-I-T-V-V-V-G-L-A-W-F-A-C-I-M-V-L-G-L-L-M-K-A-N-N


### FUNCTION One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit Associates with free 30S ribosomal subunits  Required for efficient processing of 16S rRNA May interact with the 5'-terminal helix region of 16S rRNA ### SEQUENCE -M-A-D-N-A-R-A-K-R-L-A-D-L-I-R-E-V-V-A-Q-K-L-Q-R-G-I-K-D-P-R-L-G-S-H-V-T-I-T-D-T-R-V-T-G-D-L-R-E-A-T-V-F-Y-T-V-Y-G-D-D-E-E-R-K-A-A-T-A-G-L-E-S-A-K-G-I-L-R-S-E-V-G-K-A-A-G-V-K-F-T-P-T-L-T-F-V-M-D-A-L-P-D-T-A-R-N-I-E-D-L-L-D-K-A-R-Q-S-D-E-K-V-R-E-A-S-A-G-A-T-Y-A-G-E-A-D-P-Y-R-K-P-D-E-D-E-T-D-T-E-G-A-V-E-A-D-E-T-D-D-T-A-K


### FUNCTION Channel that opens in response to stretch forces in the membrane lipid bilayer May participate in the regulation of osmotic pressure changes within the cell ### SEQUENCE -M-F-R-G-F-K-E-F-L-S-R-G-N-I-V-D-L-A-V-A-V-V-I-G-T-A-F-T-A-L-I-T-K-F-T-D-S-I-I-T-P-L-I-N-R-V-G-V-N-Q-Q-T-N-I-S-P-L-R-I-D-I-G-G-D-Q-A-I-D-L-N-I-V-L-S-A-A-I-N-F-L-L-I-A-L-V-V-Y-F-L-V-V-L-P-Y-T-T-I-R-K-H-G-E-V-E-Q-F-D-T-D-L-I-G-N-Q-V-V-L-L-A-E-I-R-D-L-L-A-Q-S-N-G-A-P-S-G-R-H-V-D-T-A-D-L-T-P-T-P-N-H-E-P-R-A-D-T


### FUNCTION One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit Associates with free 30S ribosomal subunits  Required for efficient processing of 16S rRNA May interact with the 5'-terminal helix region of 16S rRNA ### SEQUENCE -M-A-D-Q-A-R-A-R-R-L-A-K-R-I-C-T-I-V-A-S-A-I-E-F-E-I-K-D-P-G-L-D-G-V-T-I-V-D-V-K-V-T-A-D-L-H-D-A-T-V-F-Y-T-V-M-G-R-T-L-E-D-A-P-D-Y-T-A-A-T-A-A-L-N-R-A-K-G-T-L-R-S-K-V-G-A-G-T-G-V-R-F-T-P-T-L-T-F-I-R-D-T-T-S-D-S-V-A-R-M-E-E-L-L-A-R-A-R-A-A-D-A-D-V-A-Q-V-R-L-R-A-K-P-A-G-E-A-D-P-Y-R-D-K-G-S-V-A-G-L-V-G-V-D-I-A-D-I-D-D-D-D-L-T-D-D


### FUNCTION Required for maturation of 30S ribosomal subunits ### SEQUENCE -M-N-T-G-L-P-S-Q-I-Q-V-I-E-L-L-G-G-E-V-A-R-A-G-Y-E-V-E-D-V-I-I-H-T-W-S-Q-P-F-W-I-T-V-L-A-D-G-D-T-V-L-A-R-D-I-I-A-T-L-S-H-S-V-S-A-L-L-D-G-L-D-N-I-V-D-R-Y-F-L-E-V-S-S-L-G-M-G-R-P-F-T-S-E-K-H-F-R-R-A-R-G-R-K-V-E-L-A-A-V-G-R-I-P-A-D-R-S-N-W-G-D-V-R-R-H-G-D-V-G-D-P-R-R-P-R-L-C-G-M-R-D-P-A-I-E-I-M-K-A-I-V


### FUNCTION Binds directly to 16S ribosomal RNA ### SEQUENCE -M-A-N-T-P-Q-A-K-K-R-I-R-R-N-D-R-R-A-E-I-N-G-N-R-V-N-R-I-R-T-F-I-K-K-V-E-S-A-I-A-A-G-N-K-S-E-A-E-T-A-L-A-S-A-Q-P-E-L-F-R-G-V-S-K-G-V-L-H-K-N-T-A-S-R-K-F-S-R-L-A-K-G-V-A-A-L-A


### FUNCTION Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA  Also appears to be involved in tRNA biosynthesis ### SEQUENCE -L-Q-E-I-F-R-G-V-R-K-A-V-K-S-H-G-C-K-R-A-I-L-V-G-H-N-S-S-F-D-L-A-F-L-N-A-A-V-A-R-C-D-I-K-R-N-P-F-H-P-F-S-S-F-D-T-A-T-L-A-G-L-A-Y-G-Q-T-V-L-A-K-A-C-Q-S-A-G-I-E-F-D-G-R-E-A-H-S-A-R-Y-D-T-E-K-T-A-E-L-F-C-G-I-V-N-R-W-K-E-M-G-G-W-V-D-F-A


### FUNCTION May protect the nitrogenase Fe-Mo protein from oxidative damage ### SEQUENCE -M-S-A-L-T-R-Q-L-E-E-F-R-R-C-S-T-A-E-Q-Y-F-E-L-L-D-V-D-Y-D-P-R-V-V-A-V-N-R-L-H-I-L-R-Y-F-A-E-E-I-A-G-L-H-E-G-A-D-A-E-V-S-P-E-V-L-L-R-D-Y-R-A-A-L-I-R-A-Y-E-A-F-T-T-A-T-G-L-D-H-R-L-F-K-V-L-K-D-R-A-P-E-P-A-G-F-V-A-T-T-D-I-T-V-E-R-P-A-T-A-Q-S-D-E-K-G-Q-D-R


### FUNCTION Produces ATP from ADP in the presence of a proton gradient across the membrane ### SEQUENCE -M-A-N-N-I-K-L-S-I-L-T-P-Q-K-T-F-Y-V-G-D-V-K-E-I-I-T-R-T-V-E-G-E-I-G-I-L-P-N-H-T-D-L-V-A-F-L-T-P-T-E-T-I-L-V-E-E-D-G-S-R-K-K-V-F-T-S-T-G-I-L-N-V-G-E-S-E-V-S-F-M-C-D-A-S-E-W-P-D-E-I-D-I-Q-R-A-E-T-A-K-E-R-A-E-K-R-L-K-T-S-N-N-I-D-V-K-R-A-E-L-S-L-S-R-A-L-A-R-I-K-T-K-N-D


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-Y-E-F-L-D-R-R-Y-A-L-A-L-Y-E-V-G-E-K-N-Q-K-L-E-E-Y-I-N-D-F-G-E-I-V-H-L-L-K-N-D-E-N-I-N-Q-V-V-N-H-P-Q-I-S-T-S-E-K-K-K-I-F-M-E-I-F-K-G-K-I-D-E-K-L-L-N-F-L-L-L-L-L-E-K-K-R-I-H-D-A-E-G-I-L-T-Q-L-N-K-I-S-L-E-K-H-N-K-V-V-A-E-V-R-T-V-I-P-L-T-D-N-E-K-T-T-L-A-S-K-L-S-A-K-Y-N-K-I-I-I-F-K-E-I-I-D-K-T-I-I-G-G-V-Y-V-R-V-G-D-D-V-I-D-G-T-I-K-F-K-L-E-S-M-K-K-V-M-L-K-E-E


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA ### SEQUENCE -M-P-R-R-R-S-V-E-P-R-K-I-L-P-D-P-K-F-G-S-E-L-L-A-K-F-I-N-V-L-M-V-D-G-K-K-S-T-A-E-S-I-I-Y-G-A-L-E-T-L-S-Q-R-T-G-K-E-A-L-E-A-F-E-A-A-L-E-N-V-R-P-T-V-E-V-K-S-R-R-V-G-G-S-T-Y-Q-V-P-V-E-V-R-P-A-R-R-N-A-L-A-M-R-W-I-V-E-A-A-R-K-R-G-D-K-S-M-A-L-R-L-A-N-E-L-S-D-A-A-D-N-K-G-T-A-V-K-K-R-E-D-V-H-R-M-A-E-A-N-K-A-F-A-H-Y-R-W


### FUNCTION With S4 and S5 plays an important role in translational accuracy ### SEQUENCE -M-A-T-I-N-Q-L-V-R-K-P-R-V-K-K-V-V-K-S-N-V-P-A-L-E-A-C-P-Q-K-R-G-V-C-T-R-V-Y-T-T-T-P-K-K-P-N-S-A-L-R-K-V-C-R-I-R-L-T-N-G-F-E-V-I-S-Y-I-G-G-E-G-H-N-L-Q-E-H-S-V-V-L-I-R-G-G-R-V-K-D-L-P-G-V-R-Y-H-T-V-R-G-A-L-D-C-A-G-V-K-D-R-K-Q-G-R-S-K-Y-G-V-K-R-P-K-A


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA ### SEQUENCE -M-S-L-D-K-G-T-K-E-E-I-T-K-K-F-Q-L-H-E-K-D-T-G-S-A-D-V-Q-I-A-I-L-T-E-H-I-A-E-L-K-E-H-L-K-R-S-P-K-D-Q-N-S-R-L-A-L-L-K-L-V-G-Q-R-R-K-L-L-E-Y-L-N-S-T-D-T-E-R-Y-K-N-L-I-T-R-L-N-L-R-K


### FUNCTION Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit It is not involved in the protein synthesizing functions of that subunit ### SEQUENCE -M-V-R-A-T-G-S-V-A-S-R-R-R-R-K-R-I-L-K-Q-A-K-G-F-W-G-D-R-K-G-H-I-R-Q-S-R-S-S-V-M-R-A-M-A-F-N-Y-M-H-R-K-D-R-K-G-D-F-R-S-L-W-I-A-R-L-N-V-A-S-R-I-H-S-L-S-Y-S-R-L-I-N-G-L-K-C-A-N-I-S-L-N-R-K-M-L-S-E-I-A-I-H-N-P-E-G-F-A-E-I-A-N-Q-A-K-K-A-L-E-A-T-V


### FUNCTION IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins ### SEQUENCE -M-A-L-N-F-K-I-N-R-Q-I-R-A-P-K-V-R-L-I-G-S-A-G-E-Q-L-G-I-L-A-I-K-D-A-L-D-L-A-R-E-A-G-L-D-L-V-E-V-A-S-N-S-E-P-P-V-C-K-I-M-D-Y-G-K-Y-R-Y-G-L-T-K-K-E-K-D-S-K-K-A-Q-H-Q-V-R-I-K-E-V-K-L-K-P-N-I-D-E-N-D-F-S-T-K-L-K-Q-A-R-T-F-V-E-K-G-N-K-V-K-I-T-C-M-F-R-G-R-E-L-A-Y-P-E-H-G-F-K-V-V-Q-K-M-S-Q-G-L-E-D-I-G-F-V-E-A-E-P-K-L-A-G-R-S-L-I-C-V-V-A-P-G-T-V-K-T-K-K-K-Q-E-K-S-H-A-Q-D-E-N-Q


### FUNCTION Involved in transcription antitermination Required for transcription of ribosomal RNA  operons ### SEQUENCE -M-A-T-L-S-P-E-K-F-S-G-S-P-I-S-I-S-K-E-F-P-Q-Q-K-M-R-E-I-I-L-Q-M-L-Y-A-L-D-M-A-P-S-A-E-D-S-L-V-P-L-L-M-S-Q-T-A-V-S-Q-K-H-V-L-V-A-L-N-Q-T-K-S-I-L-E-K-S-Q-E-L-D-L-I-I-G-N-A-L-K-N-K-S-F-D-S-L-D-L-V-E-K-N-V-L-R-L-T-L-F-E-H-F-Y-S-P-P-I-N-K-A-I-L-I-A-E-A-I-R-L-V-K-K-F-S-Y-S-E-A-C-P-F-I-Q-A-I-L-N-D-I-F-T-D-S-S-L-N-E-N-S-L-S-I


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-K-Q-Q-L-L-L-L-E-D-V-D-G-L-G-R-S-G-D-L-I-T-A-R-P-G-Y-V-R-N-Y-L-I-P-K-K-K-A-V-I-A-G-A-G-T-L-R-L-Q-A-K-L-K-E-Q-R-L-I-Q-A-A-A-D-K-A-D-S-E-R-I-A-Q-A-L-K-D-I-V-L-E-F-Q-V-R-V-D-P-D-N-N-M-Y-G-S-V-T-I-A-D-I-I-A-E-A-A-K-K-N-I-F-L-V-R-K-N-F-P-H-A-H-Y-A-I-K-N-L-G-K-K-N-I-P-L-K-L-K-E-E-V-T-A-T-L-L-V-E-V-T-S-D-N-E-Y-V-T-V-L-A-Q-G-K-Q-T-E-E-N-Q-E-G


### FUNCTION Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit ### SEQUENCE -M-N-K-P-V-H-N-N-E-H-R-R-K-R-F-N-K-K-C-P-F-V-S-A-G-W-K-T-I-D-Y-K-D-V-E-T-L-K-K-F-I-T-E-R-G-K-V-L-P-R-R-I-T-G-V-S-S-R-F-Q-G-V-L-S-Q-A-I-K-R-A-R-H-L-G-L-L-P-F-V-G-E-D


### FUNCTION Binds together with bS18 to 16S ribosomal RNA ### SEQUENCE -M-G-K-K-E-N-Q-L-Y-E-G-A-Y-V-F-S-V-T-L-S-E-E-A-R-R-K-A-L-D-K-V-I-S-G-I-T-N-Y-G-G-E-I-H-K-I-H-D-Q-G-R-K-K-L-A-Y-T-I-R-G-A-R-E-G-Y-Y-Y-F-I-Y-F-S-V-S-P-G-A-I-T-E-L-W-K-E-Y-H-L-N-E-D-L-L-R-F-M-T-L-R-A-D-S-V-K-E-V-L-E-F-A-S-L-P-E


### FUNCTION The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis ### SEQUENCE -M-A-K-L-I-V-A-I-G-N-P-R-H-G-Y-A-N-T-R-H-N-A-G-F-L-L-A-D-R-L-V-E-E-L-Q-G-P-P-F-K-P-L-S-K-C-H-A-L-M-T-L-V-E-S-S-S-G-P-L-V-F-I-K-P-T-T-F-V-N-L-S-G-K-A-V-V-L-A-K-K-Y-F-N-V-A-L-S-H-I-L-V-L-A-D-D-V-N-R-S-F-G-K-L-R-L-C-F-N-G-G-S-G-G-H-N-G-L-K-S-I-T-A-S-L-G-S-N-E-Y-W-Q-L-R-F-G-V-G-R-P-L-E-E-G-V-E-L-S-N-F-V-L-G-K-F-S-E-E-E-N-L-Q-L-G-S-I-F-V-E-A-S-T-L-F-T-E-W-C-S-K-F


### FUNCTION This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ### SEQUENCE -M-E-L-V-V-T-S-R-E-T-G-K-K-S-F-L-K-K-I-R-Q-Q-G-G-I-P-A-V-V-Y-S-A-G-K-S-L-A-N-I-T-V-D-A-L-V-F-K-K-F-L-S-N-L-E-S-G-A-L-S-S-T-V-F-S-L-S-Y-E-G-R-I-I-K-A-L-V-K-D-I-Q-Y-Q-I-T-T-Y-D-V-I-H-L-D-F-E-E-L-V-E-D-R-P-V-K-L-N-I-P-I-R-C-I-N-A-V-D-C-I-G-V-K-L-G-G-S-L-R-Q-V-I-R-A-V-R-V-V-C-K-P-K-D-I-V-P-F-L-E-L-D-V-R-S-V-G-L-S-Q-T-R-K-L-S-D-I-K-I-P-A-G-I-E-T-I-T-P-L-K-E-V-A-I-T-V-S-R-R


### FUNCTION Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site ### SEQUENCE -M-A-K-K-S-S-V-A-R-E-A-K-R-R-R-L-V-E-A-N-F-K-K-R-S-D-L-R-K-I-V-K-S-L-S-V-S-E-E-E-K-E-N-A-R-I-S-L-N-K-M-K-R-D-T-S-P-T-R-L-H-N-R-C-L-L-T-G-R-P-R-G-Y-L-R-K-F-A-I-S-R-I-C-F-R-Q-M-A-S-M-G-E-I-P-G-V-I-K-A-S-W


### FUNCTION RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus It can also cleave other RNA substrates such as 45S RNA The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme ### SEQUENCE -M-H-P-L-T-L-P-K-Q-S-R-V-L-K-R-K-Q-F-L-Y-I-T-R-S-G-F-C-C-R-G-S-Q-A-T-F-Y-V-V-P-S-R-H-P-G-T-C-R-M-G-I-T-V-S-K-K-F-G-K-A-H-E-R-N-S-F-K-R-V-V-R-E-V-F-R-H-V-R-H-Q-L-P-N-C-Q-I-V-V-F-P-K-G-H-K-Q-R-P-V-F-S-K-L-L-Q-D-F-I-N-Q-I-P-E-G-L-H-R-L-G-K-T-K-A-T-T-G-G-E-C-T-P-K-S-E-K-C-V-T-A-P-R


### FUNCTION Involved in peptide bond synthesis Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase ### SEQUENCE -M-V-R-V-S-T-S-E-F-R-V-G-L-R-I-E-I-D-G-Q-P-Y-L-I-L-Q-N-D-F-V-K-P-G-K-G-Q-A-F-N-R-I-K-V-K-N-F-L-T-G-R-V-I-E-R-T-Y-K-S-G-E-S-V-E-T-A-D-I-V-E-R-S-M-R-L-L-Y-T-D-Q-E-G-A-T-F-M-D-D-E-T-F-E-Q-E-V-V-F-W-E-K-L-E-N-I-R-Q-W-L-L-E-D-T-I-Y-T-L-V-L-Y-N-G-D-V-V-A-V-E-P-P-I-F-M-E-L-S-I-A-E-T-A-P-G-V-R-G-D-T-A-S-G-R-V-L-K-P-A-V-T-N-T-G-A-K-I-M-V-P-I-F-I-D-E-G-E-L-V-K-V-D-T-R-T-G-S-Y-E-S-R-V-S-K


### FUNCTION Might have a role analogous to that of eukaryotic histone proteins ### SEQUENCE -M-A-L-K-D-T-A-K-K-M-K-D-L-L-D-S-I-Q-H-D-L-A-K-A-E-K-G-N-K-A-A-A-Q-R-V-R-T-D-S-I-K-L-E-K-V-A-K-L-Y-R-K-E-S-I-K-A-E-K-S-G-L-L-K-R-K-P-S-T-K-A-P-A-K-V-K-K-T-A-E-K-K-A-P-K-K-S-S-A-A-A-A-K-T-S-K-A-V-K-A-S-K-P-A-S-K-K-T-A-A-K-K-V-K-K-P-S-K-A-R-G-F-R-K


### FUNCTION The SecYEG-SecDF-YajC-YidC holo-translocon  protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions ### SEQUENCE -M-L-S-R-I-V-T-C-F-L-F-L-L-S-S-L-P-L-F-A-E-E-E-A-A-Q-S-K-N-T-F-V-Q-P-A-V-M-L-A-I-A-I-L-F-F-Y-F-I-L-W-R-P-E-Q-K-R-R-K-A-M-E-K-R-K-N-D-L-A-K-G-D-K-V-T-A-M-G-I-I-G-T-V-D-D-I-R-E-H-T-V-I-L-N-I-A-S-G-K-V-E-V-L-K-G-A-I-S-E-I-L-K-P-N-D-N-K-S


### FUNCTION Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin ### SEQUENCE -M-I-A-I-E-R-Y-Q-L-I-I-S-K-F-R-M-W-L-F-L-G-C-S-V-E-E-R-H-F-K-Q-P-V-L-I-S-V-T-F-S-Y-N-E-V-P-S-A-C-L-S-D-K-L-S-D-A-C-C-Y-L-E-V-T-S-L-I-E-E-I-A-N-T-K-P-Y-A-L-I-E-H-L-A-N-E-L-F-D-S-L-V-I-S-F-G-D-K-A-S-K-I-D-L-E-V-E-K-E-R-P-P-V-P-N-L-L-N-P-I-K-F-T-I-S-K-E-L-C-P-S-P-V-L-S-A


### FUNCTION Binds directly to 16S ribosomal RNA ### SEQUENCE -M-A-P-K-K-P-N-K-K-N-V-I-Q-R-R-P-S-A-E-K-R-I-L-T-A-Q-K-R-E-L-I-N-H-S-F-K-S-K-V-K-T-I-V-K-K-F-E-A-S-L-K-L-D-D-T-Q-A-T-L-S-N-L-Q-S-V-Y-S-V-V-D-K-A-V-K-R-G-I-F-K-D-N-K-A-A-R-I-K-S-K-A-T-L-K-V-N-A-R-A-S


### FUNCTION A probable RNA-binding protein ### SEQUENCE -M-K-E-F-L-A-Y-I-I-K-N-L-V-D-R-P-E-E-V-R-I-K-E-V-Q-G-T-H-T-I-I-Y-E-L-S-V-A-K-P-D-I-G-K-I-I-G-K-E-G-R-T-I-K-A-I-R-T-L-L-V-S-V-A-S-R-N-N-V-R-V-S-L-E-I-M-E-E-K


### FUNCTION Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis May increase the efficiency of translation by recycling ribosomes from one round of translation to another ### SEQUENCE -M-S-V-L-Q-D-T-E-K-K-M-A-A-A-L-D-F-F-H-K-E-V-K-S-F-R-T-G-K-A-H-P-A-L-V-E-T-V-V-V-D-V-Y-G-T-T-M-R-L-S-D-I-A-S-I-S-V-A-D-L-R-Q-L-V-I-S-P-Y-D-G-N-N-A-S-A-I-A-K-G-I-I-A-A-N-L-N-L-Q-P-E-V-E-G-S-I-I-R-I-K-V-P-E-P-T-A-D-Y-R-Q-E-M-I-K-Q-L-R-R-K-C-E-E-A-K-I-N-V-R-N-I-R-R-E-A-N-D-K-L-K-K-D-S-A-L-T-E-D-V-V-K-G-N-E-K-K-I-Q-E-L-T-D-K-F-C-K-Q-L-D-E-L-T-K-Q-K-E-A-E-I-A-S-I


### FUNCTION Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions ### SEQUENCE -M-V-K-I-I-S-S-E-N-F-D-S-F-I-A-S-G-L-V-L-V-D-F-F-A-E-W-C-G-P-C-R-M-L-T-P-I-L-E-N-L-A-A-E-L-P-H-V-T-I-G-K-I-N-I-D-E-N-S-K-P-A-E-T-Y-E-V-S-S-I-P-T-L-I-L-F-K-D-G-N-E-V-A-R-V-V-G-L-K-D-K-E-F-L-T-N-L-I-N-K-H-A


### FUNCTION One of the early assembly proteins it binds 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome Forms the main docking site for trigger factor binding to the ribosome ### SEQUENCE -M-K-D-P-Y-D-V-I-K-R-H-Y-V-T-E-K-A-K-M-L-E-H-L-S-A-G-T-G-E-G-K-K-K-G-S-F-C-K-D-P-K-F-V-F-I-V-S-H-D-A-T-K-P-L-I-A-Q-A-L-E-A-I-Y-V-D-K-N-V-K-V-K-S-V-N-T-I-N-V-K-P-Q-P-A-R-M-F-R-G-R-R-K-G-K-T-S-G-F-K-K-A-I-V-T-F-Y-Q-G-H-S-V-G


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-S-R-S-L-R-K-G-P-F-V-D-H-H-L-L-K-K-V-R-A-M-N-I-E-E-K-K-T-P-I-K-T-W-S-R-R-S-M-I-T-P-E-M-I-G-H-T-F-E-V-H-N-G-K-K-F-L-T-V-F-V-S-E-T-M-V-G-H-K-L-G-E-F-S-P-T-R-I-F-K-S-H-P-V-K-K-G


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-F-K-A-T-A-R-Y-I-R-V-Q-P-R-K-A-R-L-A-A-G-L-M-R-N-L-S-V-Q-E-A-E-E-Q-L-G-F-S-Q-L-K-A-G-R-C-L-K-K-V-L-N-S-A-V-A-N-A-E-L-H-E-N-I-K-R-E-N-L-S-V-T-E-V-R-V-D-A-G-P-V-Y-K-R-S-K-S-K-S-R-G-G-R-S-P-I-L-K-R-T-S-H-L-T-V-I-V-G-E-K-E-R


### FUNCTION Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs ### SEQUENCE -M-L-M-P-K-R-T-K-F-R-K-Q-Q-K-G-Q-F-A-G-L-S-K-G-A-T-F-V-D-F-G-E-Y-A-M-Q-T-L-E-R-G-W-V-T-S-R-Q-I-E-A-C-R-V-A-I-N-R-Y-L-K-R-R-G-K-V-W-I-R-I-F-P-D-K-S-V-T-K-K-P-A-E-T-R-M-G-K-G-K-G-A-P-D-H-W-V-A-V-V-R-P-G-R-I-L-F-E-V-A-N-V-S-K-E-D-A-Q-D-A-L-R-R-A-A-A-K-L-G-I-K-T-R-F-V-K-R-V-E-R-V


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-A-S-E-P-R-G-S-R-K-V-K-I-G-V-V-V-S-A-K-M-E-K-T-V-V-V-R-V-E-R-I-F-S-H-P-Q-Y-L-K-V-V-R-S-S-K-K-Y-Y-A-H-T-E-L-K-V-S-E-G-D-K-V-K-I-Q-E-T-R-P-L-S-K-L-K-R-W-R-V-I-E-H-V-G-V-V-S


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-Q-E-S-Q-L-K-V-A-D-N-T-G-A-K-K-V-K-C-F-K-V-L-G-G-S-R-R-R-Y-A-T-V-G-D-V-I-V-C-S-V-R-D-V-E-P-N-S-S-I-K-K-G-D-V-I-K-A-V-I-V-R-T-R-R-H-I-T-R-K-D-G-S-T-L-K-F-D-T-N-S-C-V-I-I-D-D-K-G-N-P-K-G-T-R-I-F-G-P-V-A-R-E-I-R-D-R-G-F-I-K-I-S-S-L-A-P-E-V-I


### FUNCTION One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit ### SEQUENCE -M-K-K-Q-N-I-R-V-G-D-K-V-F-I-L-A-G-N-D-K-G-K-E-G-K-V-L-S-L-T-E-D-K-V-V-V-E-G-V-N-V-R-I-K-N-I-K-R-S-Q-Q-N-P-K-G-K-R-I-S-I-E-A-P-I-H-I-S-N-V-R-L-T-I-A-G-E-P-A-K-L-S-V-K-V-T-E-Q-G-R-E-L-W-Q-R-R-P-D-G-T-S-Q-L-Y-R-L-V-R-G-K-K-G


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-S-R-L-K-K-F-Y-T-E-E-I-R-K-S-L-F-E-K-F-G-Y-A-N-K-M-Q-I-P-V-L-K-K-I-V-L-S-M-G-L-A-E-A-A-K-D-K-N-L-F-Q-A-H-L-E-E-L-T-M-I-S-G-Q-K-P-L-V-T-K-A-R-N-S-I-A-G-F-K-L-R-E-G-Q-G-I-G-A-K-V-T-L-R-G-I-R-M-Y-D-F-M-D-R-F-C-N-I-V-S-P-R-I-R-D-F-R-G-F-S-N-K-G-D-G-R-G-C-Y-S-V-G-L-D-D-Q-Q-I-F-P-E-I-N-L-D-R-V-K-R-T-Q-G-L-N-I-T-W-V-T-T-A-Q-T-D-D-E-C-T-T-L-L-E-L-M-G-L-R-F-K-K-A-Q


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-G-M-T-S-D-S-I-A-D-L-L-T-R-I-R-N-A-L-M-A-E-H-L-Y-V-D-V-E-H-S-K-M-R-E-A-I-V-K-I-L-K-H-K-G-F-V-A-H-Y-L-V-K-E-E-N-R-K-R-A-M-R-V-F-L-Q-Y-S-D-D-R-K-P-V-I-H-Q-L-K-R-V-S-K-P-S-R-R-V-Y-V-S-A-A-K-I-P-Y-V-F-G-N-M-G-I-S-V-L-S-T-S-Q-G-V-M-E-G-S-L-A-R-S-K-N-I-G-G-E-L-L-C-L-V-W


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-S-R-K-A-R-E-P-I-L-L-P-Q-G-V-E-V-S-I-Q-D-D-K-I-I-V-K-G-P-K-G-S-L-T-Q-K-S-V-K-E-V-E-I-T-L-K-D-N-S-I-F-V-H-A-A-P-H-V-V-D-R-P-S-C-M-Q-G-L-Y-W-A-L-I-S-N-M-V-Q-G-V-H-L-G-F-E-K-R-L-E-M-I-G-V-G-F-R-A-S-V-Q-G-A-F-L-D-L-S-I-G-V-S-H-P-T-K-I-P-I-P-S-T-L-Q-V-S-V-E-K-N-T-L-I-S-V-K-G-L-D-K-Q-L-V-G-E-F-A-A-S-I-R-A-K-R-P-P-E-P-Y-K-G-K-G-I-R-Y-E-N-E-Y-V-R-R-K-A-G-K-A-A-K-T-G-K-K


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-E-S-S-L-C-K-K-S-L-M-K-R-R-R-A-L-R-V-R-K-V-L-K-G-S-P-T-K-P-R-L-S-V-V-K-T-N-K-H-I-Y-V-Q-L-I-D-D-S-I-G-K-T-L-A-S-V-S-T-L-S-K-L-N-K-S-Q-G-L-T-K-K-N-Q-E-V-A-K-V-L-G-T-Q-I-A-E-L-G-K-N-L-Q-L-D-R-V-V-F-D-R-G-P-F-K-Y-H-G-I-V-S-M-V-A-D-G-A-R-E-G-G-L-Q-F


### FUNCTION With S4 and S12 plays an important role in translational accuracy ### SEQUENCE -M-S-L-S-K-N-S-H-K-E-D-Q-L-E-E-K-V-L-V-V-N-R-C-S-K-V-V-K-G-G-R-K-F-S-F-S-A-L-I-L-V-G-D-G-K-G-R-L-G-Y-G-F-A-K-A-N-E-L-T-D-A-I-R-K-G-G-E-A-A-K-K-N-L-M-K-I-E-A-L-E-D-G-S-I-P-H-E-V-L-V-H-H-D-G-A-Q-L-L-L-K-P-A-K-P-G-T-G-I-V-A-G-S-R-I-R-L-I-L-E-M-A-G-I-K-D-I-V-A-K-S-F-G-S-N-N-P-M-N-Q-V-K-A-A-F-K-A-L-T-G-L-S-P-R-K-D-L-L-R-R-G-A-A-I-N-D


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-I-K-L-E-S-L-F-D-I-S-E-R-K-R-R-K-K-L-L-G-R-G-P-S-S-G-H-G-K-T-S-G-R-G-H-K-G-D-G-S-R-S-G-Y-K-R-R-F-G-Y-E-G-G-G-V-P-L-Y-R-R-V-P-T-R-G-F-S-H-K-R-F-D-K-C-V-E-E-I-T-T-G-R-L-A-E-L-F-Q-E-G-E-A-I-T-L-D-A-L-K-A-K-K-A-I-A-R-Q-A-V-R-V-K-V-I-L-K-G-D-L-E-K-T-F-V-W-Q-D-T-A-V-V-L-S-Q-G-V-Q-N-L-L-G-I-T


### FUNCTION Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA Forms part of the Shine-Dalgarno cleft in the 70S ribosome ### SEQUENCE -M-V-K-N-Q-A-Q-A-K-K-S-V-K-R-K-Q-L-K-N-I-P-S-G-V-V-H-V-K-A-T-F-N-N-T-I-V-S-I-T-D-P-A-G-N-V-I-S-W-A-S-A-G-K-V-G-Y-S-G-S-R-K-S-S-A-F-A-A-T-V-A-A-Q-D-A-A-K-T-A-M-N-S-G-L-K-E-V-E-V-C-L-K-G-T-G-A-G-R-E-S-A-V-R-A-L-I-S-A-G-L-V-V-S-V-I-R-D-E-T-P-V-P-H-N-G-C-R-P-R-K-R-R-R-V


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA ### SEQUENCE -M-S-R-R-H-S-A-E-K-R-D-I-P-G-D-P-I-Y-G-S-V-I-L-E-K-F-I-N-K-V-M-M-H-G-K-K-S-V-A-R-K-I-V-Y-S-A-L-E-R-F-G-K-K-L-N-L-E-N-V-L-E-G-F-G-E-A-L-E-N-A-K-P-I-L-E-V-R-S-R-R-V-G-G-A-T-Y-Q-V-P-V-E-V-A-S-E-R-R-N-C-L-A-M-Q-W-I-I-K-H-A-R-S-K-P-G-K-S-M-E-V-G-L-A-T-E-L-I-D-C-F-N-K-Q-G-A-T-I-K-K-R-E-D-T-H-R-M-A-E-A-N-K-A-F-A-H-Y-K-W


### FUNCTION Involved in the binding of tRNA to the ribosomes ### SEQUENCE -M-K-Q-Q-K-Q-K-I-R-I-R-L-K-G-F-D-Q-G-Q-L-D-R-S-T-A-D-I-V-E-T-A-K-R-T-G-A-R-V-V-G-P-I-P-L-P-T-K-R-E-V-Y-T-V-L-R-S-P-H-V-D-K-K-S-R-E-Q-F-E-I-R-T-H-K-R-L-V-D-I-L-D-P-T-G-K-T-I-D-A-L-K-M-L-A-L-P-A-G-V-D-I-K-I-K-A-A


### FUNCTION This protein binds to 23S rRNA in the presence of protein L20 ### SEQUENCE -M-E-P-Y-A-V-I-Q-T-G-S-K-Q-Y-Q-V-R-S-G-D-V-I-D-V-E-L-L-G-E-V-A-S-D-K-E-V-I-F-Q-D-V-L-F-V-F-D-G-T-K-A-S-L-G-S-P-T-I-A-N-A-Q-V-K-A-E-Y-L-S-H-V-K-G-E-K-V-V-A-Y-K-Y-K-K-R-K-N-Y-H-R-K-H-G-H-R-Q-K-Y-L-R-V-K-I-R-E-I-L-I


### FUNCTION Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes ### SEQUENCE -M-Q-C-P-F-C-N-H-G-E-L-K-V-I-D-S-R-N-A-P-E-A-N-A-I-K-R-R-R-E-C-L-K-C-S-Q-R-F-T-T-F-E-T-V-E-L-T-L-Q-V-L-K-R-D-G-R-Y-E-N-F-Q-E-S-K-L-I-H-G-L-N-A-A-S-S-H-T-R-I-G-Q-D-Q-V-H-A-I-A-S-N-V-K-S-E-L-L-G-K-Q-N-R-E-I-S-T-K-E-I-G-E-L-V-M-K-Y-L-K-K-A-D-M-I-A-Y-I-R-F-A-C-V-Y-R-R-F-K-D-V-G-E-L-M-E-V-L-L-S-A-T-P-D-M-E-K


### FUNCTION Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-uracil ### SEQUENCE -M-F-S-G-I-I-Q-E-L-G-E-V-C-F-F-E-A-Q-G-N-G-L-S-L-G-I-K-S-T-P-L-F-V-T-P-L-V-T-G-D-S-V-A-V-D-G-V-C-L-T-L-T-S-C-N-E-S-K-I-F-F-D-V-I-P-E-T-L-A-C-T-T-L-G-E-K-R-C-S-D-Q-V-N-L-E-A-A-L-K-M-G-D-S-I-G-G-H-L-L-S-G-H-V-F-G-T-A-E-I-F-L-I-K-E-N-R-Y-Y-F-R-G-S-K-E-L-S-Q-Y-L-F-E-K-G-F-I-A-I-D-G-I-S-L-T-L-V-S-V-D-S-D-T-F-S-V-G-L-I-P-E-T-L-Q-R-T-T-L-G-K-K-R-E-G-E-R-V-N-I-E-I-D-M-S-T-K-I-Q-V-D-T-V-K-R-I-L-A-S-S-G-K-D


### FUNCTION Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ### SEQUENCE -M-T-Q-E-K-I-K-I-H-V-S-N-E-Q-T-C-I-P-I-H-L-V-S-V-E-K-L-V-L-T-L-L-E-H-L-K-V-T-T-N-E-I-F-I-Y-F-L-E-D-K-A-L-A-E-L-H-D-K-V-F-A-D-P-S-L-T-D-T-I-T-L-P-I-D-A-P-G-D-P-A-Y-P-H-V-L-G-E-A-F-I-S-P-Q-A-A-L-R-F-L-E-N-T-S-P-N-Q-E-D-I-Y-E-E-I-S-R-Y-L-V-H-S-I-L-H-M-L-G-Y-D-D-T-S-S-E-E-K-R-K-M-R-V-K-E-N-Q-I-L-C-M-L-R-K-K-H-A-L-L-T-A


### FUNCTION Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ ### SEQUENCE -M-T-D-T-P-P-E-N-E-E-Q-H-E-S-N-V-Q-N-E-N-E-V-E-H-L-Q-Q-E-I-V-T-L-K-T-E-L-K-E-K-N-D-K-Y-L-M-A-L-A-E-S-E-N-S-R-K-R-L-Q-K-E-R-Q-E-L-M-Q-Y-A-L-E-N-T-L-I-D-F-L-N-P-I-E-S-M-E-K-A-L-G-F-A-T-Q-M-S-D-D-V-K-N-W-A-L-G-F-N-M-I-L-N-Q-F-K-Q-I-F-E-E-K-G-I-I-E-Y-S-S-I-G-Q-K-F-N-P-F-L-H-E-A-V-Q-T-E-E-T-S-E-V-P-E-G-T-I-L-E-E-F-A-K-G-Y-K-I-G-E-R-P-I-R-V-A-K-V-K-V-A-K-A-P-T-P-K-E-N-K-E


### FUNCTION Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions ### SEQUENCE -M-A-T-M-T-K-K-K-L-I-S-T-I-S-Q-D-H-K-I-H-P-N-H-V-R-T-V-I-Q-N-F-L-D-K-M-T-D-A-L-V-K-G-D-R-L-E-F-R-D-F-G-V-L-Q-V-V-E-R-K-P-K-V-G-R-N-P-K-N-A-A-V-P-I-H-I-P-A-R-R-A-V-K-F-T-P-G-K-R-M-K-R-L-I-E-T-P-N-K-H-S


### FUNCTION Might have a role in establishing the nucleoid structure of elementary bodies ### SEQUENCE -M-I-G-A-Q-K-K-Q-S-G-K-K-T-A-S-R-A-V-R-K-P-A-K-K-V-A-A-K-R-T-V-K-K-A-T-V-R-K-T-A-V-K-K-P-A-V-R-K-T-A-A-K-K-T-V-A-K-K-T-T-A-K-R-T-V-R-K-T-V-A-K-K-P-A-V-K-K-V-A-A-K-R-V-V-K-K-T-V-A-K-K-T-T-A-K-R-A-V-R-K-T-V-A-K-K-P-V-A-R-K-T-T-V-A-K-G-S-P-K-K-A-A-A-C-A-L-A-C-H-K-N-H-K-H-T-S-S-C-K-R-V-C-S-S-T-A-T-R-K-H-G-S-K-S-R-V-R-T-A-H-G-W-R-H-Q-L-I-K-M-M-S-R


### FUNCTION Required for rescue of stalled ribosomes mediated by trans-translation Binds to transfer-messenger RNA , required for stable association of tmRNA with ribosomes tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB tmRNA is encoded by the ssrA gene ### SEQUENCE -M-A-Q-K-E-I-V-S-N-R-K-A-L-R-N-Y-E-V-I-E-T-L-E-A-G-I-V-L-T-G-T-E-I-K-S-L-R-D-H-G-G-N-L-G-D-A-Y-V-I-V-S-K-G-E-G-W-L-L-N-A-S-I-A-P-Y-R-F-G-N-I-Y-N-H-E-E-R-R-K-R-K-L-L-L-H-R-Y-E-L-R-K-L-E-G-K-I-A-Q-K-G-M-T-L-I-P-L-G-M-F-L-S-R-G-Y-V-K-V-R-L-G-C-C-R-G-K-K-A-Y-D-K-R-R-T-I-I-E-R-E-K-E-R-E-V-A-A-A-M-K-R-R-H-H


### FUNCTION One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit Associates with free 30S ribosomal subunits  Required for efficient processing of 16S rRNA May interact with the 5'-terminal helix region of 16S rRNA ### SEQUENCE -M-T-E-N-R-R-I-K-R-V-N-A-L-L-Q-E-A-I-A-K-V-I-L-K-D-V-K-H-P-K-I-S-N-L-W-I-T-V-T-R-V-S-L-S-K-D-L-H-S-A-R-V-Y-V-S-V-M-P-H-E-N-T-K-E-E-A-L-E-A-L-K-V-S-A-G-F-I-A-H-R-A-S-K-N-V-V-L-K-Y-F-P-E-L-H-F-Y-L-D-D-I-F-S-P-Q-D-Y-I-E-N-L-L-W-Q-I-Q-E-K-E-K-S


### FUNCTION Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein ### SEQUENCE -M-E-I-I-H-I-G-T-D-I-I-E-I-S-R-I-R-E-A-I-A-T-H-G-N-R-L-L-N-R-I-F-T-E-A-E-Q-K-Y-C-L-E-K-T-D-P-I-P-S-F-A-G-R-F-A-G-K-E-A-V-A-K-A-L-G-T-G-I-G-S-V-V-A-W-K-D-I-E-V-F-K-V-S-H-G-P-E-V-L-L-P-S-H-V-Y-A-K-I-G-I-S-K-V-I-L-S-I-S-H-C-K-E-Y-A-T-A-T-A-I-A-L-A


### FUNCTION May play a role in DNA repair It seems to be involved in an RecBC-independent recombinational process of DNA repair It may act with RecF and RecO ### SEQUENCE -M-T-R-Y-P-D-Y-L-S-K-L-I-F-F-L-R-K-L-P-G-I-G-F-K-T-A-E-K-L-A-F-E-L-I-S-W-D-S-E-Q-L-K-I-L-G-N-A-F-H-N-V-A-S-E-R-S-H-C-P-L-C-F-T-L-K-E-S-K-E-A-D-C-H-F-C-R-E-E-R-D-N-Q-S-L-C-I-V-A-S-P-K-D-V-F-F-L-E-R-S-K-V-F-K-G-R-Y-H-V-L-G-S-L-L-S-P-I-T-G-K-H-I-E-N-E-R-L-S-I-L-K-S-R-I-E-T-L-C-P-K-E-I-I-L-A-I-D-A-T-L-E-G-D-A-T-A-L-F-L-K-Q-E-L-Q-H-F-S-V-N-I-S-R-L-A-L-G-L-P-I-G-L-S-F-D-Y-V-D-S-G-T-L-A-R-A-F-S-G-R-H-S-Y


### FUNCTION Carrier of the growing fatty acid chain in fatty acid biosynthesis ### SEQUENCE -M-S-L-E-D-D-V-I-A-I-I-V-E-Q-L-G-V-D-P-K-E-V-N-E-N-S-S-F-I-E-D-L-N-A-D-S-L-D-L-T-E-L-I-M-T-L-E-E-K-F-A-F-E-I-S-E-E-D-A-E-K-L-R-T-V-G-D-V-F-T-Y-I-K-K-R-Q-A-E-Q


### FUNCTION Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor  to the flavin N5 and C6 atoms of FMN ### SEQUENCE -M-K-R-Y-V-V-G-I-S-G-A-S-G-V-I-L-A-V-K-L-I-K-E-L-V-N-A-K-H-Q-V-E-V-I-I-S-P-S-G-R-K-T-L-Y-Y-E-L-G-C-Q-S-F-D-A-L-F-S-E-E-N-L-E-Y-I-H-T-H-S-I-Q-A-I-E-S-S-L-A-S-G-S-C-P-V-E-A-T-I-I-I-P-C-S-M-T-T-V-A-A-I-S-I-G-L-A-D-N-L-L-R-R-V-A-D-V-A-L-K-E-R-R-P-L-I-L-V-P-R-E-T-P-L-H-T-I-H-L-E-N-L-L-K-L-S-K-S-G-A-T-I-F-P-P-M-P-M-W-Y-F-K-P-Q-S-V-E-D-L-E-N-A-L-V-G-K-I-L-A-Y-L-N-I-P-S-D-L-T-K-Q-W-S-N-P-E


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-E-K-R-K-D-T-K-T-T-I-V-K-S-S-E-T-T-K-S-W-Y-V-V-D-A-A-G-K-T-L-G-R-L-S-S-E-V-A-K-I-L-R-G-K-H-K-V-T-Y-T-P-H-V-A-M-G-D-G-V-I-V-I-N-A-E-K-V-R-L-T-G-A-K-K-G-Q-K-I-Y-R-Y-Y-T-G-Y-I-S-G-M-R-E-I-P-F-E-N-M-M-A-R-K-P-N-Y-I-I-E-H-A-I-K-G-M-M-P-R-T-R-L-G-K-K-Q-L-K-S-L-R-I-V-K-G-D-S-Y-E-T-F-E-S-Q-K-P-I-L-L-D-I


### FUNCTION Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA ### SEQUENCE -M-S-K-P-S-S-C-K-A-Y-L-G-I-D-Y-G-K-K-R-I-G-L-A-Y-A-A-E-P-L-L-L-T-L-P-I-G-N-I-E-A-G-K-N-L-K-L-S-A-E-A-L-H-K-I-I-L-S-R-N-I-T-C-V-V-L-G-N-P-L-P-M-Q-K-G-L-Y-S-S-L-Q-E-E-V-S-L-L-A-E-E-L-K-K-L-S-T-V-E-I-I-L-W-D-E-R-L-S-S-V-Q-A-E-R-M-L-K-Q-D-C-G-L-S-R-K-D-R-K-G-K-T-D-S-L-A-A-T-L-I-L-T-S-F-L-D-S-L-P-K-K-L-T-L