### FUNCTION Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA In the 70S ribosome it contacts the 23S rRNA , connecting the 2 subunits ### SEQUENCE -M-A-K-K-P-Y-G-E-V-T-K-D-I-V-H-I-A-D-V-D-L-D-G-H-K-P-I-Y-V-E-L-R-K-V-V-G-V-N-W-M-F-A-H-A-V-C-A-A-L-G-I-D-K-W-R-K-I-G-S-L-S-D-E-E-L-E-K-L-E-D-A-L-R-N-P-W-K-Y-G-I-P-S-W-L-Y-N-R-R-R-D-P-E-T-G-K-D-L-H-L-V-G-N-D-Y-K-I-T-M-E-F-D-I-K-R-E-M-Q-I-N-S-W-R-G-Y-R-H-R-E-G-L-P-V-R-G-Q-R-T-R-S-H-H-R-K-G-R-T-V-G-V-I-K-K-K


### FUNCTION eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA ### SEQUENCE -M-E-Y-N-Y-F-E-L-L-E-R-A-Y-Q-K-L-K-D-V-I-K-Q-E-Q-I-R-W-N-P-P-I-P-H-I-E-Y-V-K-N-R-T-I-I-T-N-F-K-Q-I-A-N-Y-L-N-R-D-P-K-I-I-A-K-F-F-S-K-E-L-F-V-Q-T-I-I-E-G-N-S-L-I-I-N-K-R-V-S-Y-E-T-I-K-K-K-L-D-E-F-I-N-I-F-V-I-C-P-V-C-K-R-P-D-T-E-L-I-E-R-G-R-K-I-Y-Y-I-K-C-H-A-C-G-S-E-S-P-V-N-Y-E-L


### FUNCTION With S4 and S5 plays an important role in translational accuracy Located at the interface of the 30S and 50S subunits ### SEQUENCE -M-V-P-N-G-L-F-A-G-R-K-L-K-K-I-R-K-K-F-R-W-N-D-Y-R-Y-V-R-R-M-L-R-I-K-E-K-Y-D-P-L-E-G-A-P-M-A-S-G-I-V-L-E-K-T-D-V-E-R-R-Q-P-N-S-G-R-I-K-V-V-R-V-Q-L-K-K-N-G-K-V-V-T-A-F-T-P-G-D-G-A-I-K-V-I-D-E-H-D-E-V-L-I-V-G-I-R-G-R-Q-G-R-S-M-G-D-I-P-G-V-R-Y-K-V-Y-L-V-N-G-Q-P-L-E-L-L-R-K-G-K-I-E-K-A-R-R


### FUNCTION Involved in the binding of tRNA to the ribosomes ### SEQUENCE -M-P-F-L-R-I-K-I-Y-S-T-D-L-E-E-L-N-R-V-V-E-K-I-K-E-I-V-K-Q-T-G-V-K-M-R-G-P-I-P-L-P-T-K-I-L-R-V-P-V-L-R-I-T-G-H-R-G-T-K-I-W-D-T-Y-Q-M-R-I-H-R-R-I-I-D-I-A-T-D-D-R-T-I-K-L-L-M-R-T-P-L-I-T-K-P-E-K-I-Q-I-Q-L-K-Y-I-K-D-K-N-L


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-A-H-G-P-R-Y-R-V-P-F-R-R-R-R-E-G-K-T-V-Y-R-K-R-L-K-L-L-L-S-G-K-P-R-L-V-V-R-R-F-N-S-N-I-L-A-Q-L-V-E-Y-D-P-K-G-D-R-V-I-F-T-I-H-S-N-V-L-K-K-Y-G-W-K-G-H-R-G-N-L-P-S-A-Y-L-V-G-L-I-A-G-Y-E-A-L-K-R-G-Y-K-E-A-V-L-D-I-G-R-Y-K-S-T-K-G-N-A-L-Y-A-V-L-K-G-A-L-D-A-G-L-N-I-P-H-S-E-T-I-L-P-S-E-D-R-I-R-G-E-H-I-A-N-Y-A-K-M-L-K-E-N-E-E-L-Y-K-K-Q-F-S-R-Y-L-K-E-G-L-D-P-E-Q-L-P-N-H-F-E-E-V-K-Q-K-I-I-S-Q-Y-Q


### FUNCTION Endonuclease that removes tRNA introns Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp ### SEQUENCE -M-I-G-Y-L-F-G-N-R-V-L-V-D-D-K-E-L-P-L-I-E-A-Y-Y-L-L-D-K-G-E-L-E-V-Y-E-D-D-K-K-L-S-K-E-E-F-L-K-K-C-L-T-Y-D-E-R-F-L-I-R-Y-K-A-Y-K-E-L-R-D-K-G-Y-T-L-G-T-A-L-K-F-G-A-D-F-R-V-Y-D-I-G-V-I-P-K-K-G-K-R-S-E-R-E-H-S-K-W-V-L-Y-P-V-S-K-D-E-T-F-D-F-Y-E-F-A-S-K-N-R-V-A-H-S-T-R-K-K-L-L-L-G-I-V-S-D-K-I-E-F-I-E-V-S-W-K-K-P


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit Is located at the subunit interface close to the decoding center ### SEQUENCE -M-K-M-K-L-F-G-R-W-D-Y-E-D-V-T-V-E-D-P-G-L-R-D-Y-I-N-L-K-P-M-L-I-P-Y-S-G-G-R-H-Q-K-H-R-F-G-K-A-K-I-P-I-I-E-R-L-A-G-R-L-M-T-S-G-H-L-G-K-K-H-K-W-T-S-E-H-Q-T-G-K-K-Y-N-A-Y-K-I-I-I-R-T-F-E-I-I-E-K-R-T-K-Q-N-P-L-K-V-F-V-K-A-I-E-N-A-A-P-R-E-E-T-T-T-I-E-Y-G-G-A-R-Y-P-K-A-V-D-C-S-P-Q-R-R-V-D-L-A-I-R-H-M-V-W-G-A-F-H-G-S-R-K-K-P-I-S-I-E-E-A-L-A-E-E-I-I-N-A-Y-N-N-S-L-K-S-Y-A-I-K-R-K-L-E-I-E-K-T-A-E-S-A-R


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-R-I-P-I-I-K-Y-E-I-P-I-P-E-N-V-K-V-S-Y-E-N-N-I-L-K-V-S-G-P-K-G-E-V-E-R-K-F-Y-H-P-L-I-K-L-S-V-N-D-N-K-I-I-L-E-T-Y-F-A-T-R-R-E-K-R-L-I-N-T-W-R-S-H-I-K-N-M-L-E-G-V-Q-N-P-F-V-Y-R-L-K-V-C-Y-T-H-F-P-M-R-V-K-L-E-G-N-K-L-I-V-E-N-F-L-G-E-K-A-P-I-I-K-E-L-P-Y-L-D-K-V-K-V-K-I-E-Q-N-K-D-E-T-E-I-V-V-E-S-P-D-K-E-K-A-G-I-V-A-S-M-I-E-Q-S-T-R-F-L-H-K-R-K-D-R-R-R-F-T-D-G-I-W-L-Y-Y-K-A-G-K-N-I-L-E-E


### FUNCTION Catalyzes the hydrolysis of inorganic pyrophosphate  forming two phosphate ions ### SEQUENCE -M-E-V-Y-A-F-I-E-V-P-K-G-S-N-V-K-Y-E-Y-E-D-G-K-L-K-V-D-R-I-L-Y-G-A-M-F-Y-P-Y-N-Y-G-F-I-P-E-T-L-E-E-D-G-D-P-L-D-V-L-V-I-T-E-E-P-L-V-P-G-S-Y-I-K-V-K-P-I-G-V-L-V-T-E-D-E-K-G-V-D-R-K-I-I-A-V-P-V-K-K-V-D-P-I-Y-G-E-I-E-D-I-S-E-L-K-E-G-I-K-L-K-I-K-H-F-F-E-R-Y-K-E-L-E-P-G-K-F-V-K-V-K-E-F-L-G-K-E-E-A-E-K-I-I-K-Q-A-Q-E-N-Y-K-K-Q


### FUNCTION Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein  and RNA polymerase recruitment Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes ### SEQUENCE -M-P-T-S-K-Q-I-I-N-K-K-Q-D-E-V-S-D-I-Y-G-K-E-M-I-R-V-I-R-S-L-L-K-H-K-I-I-D-T-E-S-L-S-K-K-T-G-Y-S-I-N-T-V-R-R-A-L-Y-T-L-Q-K-M-G-I-V-R-Y-I-N-K-E-D-K-T-L-W-Q-L-L-E-T-D-Y-E-K-I-L-D-T-L-L-E-P-Y-K-K-E-E-K-A-E-T-G-E-L-L-F-I-C-P-K-C-G-R-K-Y-T-L-D-E-A-E-M-Y-E-F-R-C-P-E-D-G-T-L-L-V-A-N-Q


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-I-F-S-T-M-A-K-E-F-R-Y-K-G-Y-T-L-Q-E-L-E-Q-M-S-L-E-E-L-A-K-I-M-P-A-R-Q-R-R-T-L-L-R-R-L-K-F-G-W-S-D-Q-Q-K-K-L-F-K-K-I-L-L-A-K-E-G-K-Y-K-K-P-I-K-T-H-A-R-N-T-I-I-L-P-F-M-V-G-V-T-V-H-V-Y-N-G-K-E-Y-V-P-V-Q-I-K-P-E-M-I-G-H-Y-L-G-E-F-S-F-T-T-K-R-P-K-H-S-A-P-G-I-G-A-T-R-S-S-A-H-V-S-K-K


### FUNCTION CRISPR  Functions as a ssRNA-specific endoribonuclease Involved in the integration of spacer DNA into the CRISPR cassette ### SEQUENCE -M-Q-Y-K-I-N-M-Y-A-I-V-V-Y-D-V-N-V-S-R-Q-N-Q-I-R-E-F-L-R-K-Y-L-Y-H-V-Q-R-S-V-F-E-G-E-I-S-P-S-S-L-Y-Y-M-K-K-I-L-Q-S-Y-I-G-E-T-D-S-L-I-I-Y-V-L-R-D-K-S-C-L-M-D-K-I-V-L-G-E-D-K-D-L-Q-I-Y


### FUNCTION Located on the platform of the 30S subunit ### SEQUENCE -M-A-K-E-R-W-G-V-A-H-I-Y-S-S-E-N-N-T-I-I-H-I-T-D-I-T-G-A-E-T-I-A-V-G-S-G-G-M-V-V-N-A-D-R-L-E-G-S-P-T-A-A-I-L-A-A-K-R-A-A-A-L-A-K-E-R-G-I-T-G-L-H-I-K-V-R-A-P-G-G-H-N-G-P-W-I-P-G-P-G-A-S-A-A-I-K-T-L-A-R-E-G-L-K-I-G-I-I-E-D-V-T-P-T-P-H-D-G-C-R-R-K-G-G-K-R-G-R-R-V


### FUNCTION Binds to 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome ### SEQUENCE -M-M-L-L-Q-T-E-K-A-L-R-L-L-E-Q-Y-N-T-I-T-I-L-V-P-R-E-Y-T-K-S-K-I-K-E-F-F-E-K-K-G-Y-K-V-K-K-V-N-T-L-I-T-K-K-G-L-K-K-A-Y-V-R-F-K-E-E-G-V-A-R-K-V-A-E-E-L-G-G-L


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-E-H-P-M-R-K-I-R-I-E-K-V-T-L-N-I-G-V-G-E-S-G-E-K-L-D-K-A-Y-E-L-L-K-R-L-T-G-Q-K-P-V-K-T-K-A-K-V-R-V-E-Q-W-H-I-R-P-G-L-P-I-G-V-K-V-T-L-R-G-E-K-A-Y-K-I-L-K-E-K-L-L-P-A-V-D-F-K-I-K-A-S-S-F-T-D-R-G-F-G-F-G-I-P-E-Y-I-M-I-P-G-M-K-Y-D-P-E-L-G-L-I-G-L-E-A-Y-V-T-L-E-R-P-G-Y-R-V-E-R-R-R-I-K-R-S-K-V-G-S-R-H-R-L-N-K-E-E-I-I-K-W-A-Q-E-E-L-G-V-Q-I-I


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-K-P-I-S-A-S-I-V-R-A-L-P-V-G-A-Y-L-N-V-A-D-N-S-G-A-K-V-V-K-L-I-A-V-K-G-Y-K-G-R-K-R-R-L-A-K-A-G-I-A-D-L-V-I-V-S-V-R-D-G-K-P-D-M-I-G-Q-I-F-K-A-V-V-V-R-M-K-K-E-W-R-R-R-D-G-T-R-I-K-F-E-D-N-A-V-A-L-L-K-D-D-Y-G-T-P-K-G-T-I-I-K-T-P-I-A-K-E-V-A-E-R-W-P-D-L-A-K-I-A-R-I-I-V


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-E-F-L-G-E-L-I-Y-D-A-E-G-L-V-L-G-R-L-A-S-I-V-A-R-N-L-K-R-G-Y-R-V-K-I-V-N-A-E-K-A-I-I-T-G-D-P-N-M-V-K-K-E-W-L-Q-K-V-K-R-G-D-Y-Y-K-G-P-F-Y-P-K-R-P-D-N-I-L-K-R-V-I-R-G-M-L-P-R-K-T-A-R-G-R-E-L-L-K-N-V-K-V-Y-I-G-V-P-E-E-L-K-D-K-P-K-L-G-L-N-L-E-N-A-K-G-Y-P-E-A-L-I-K-E-V-L-K-A-K-P-K-F-E-R-G-N-I-K-Y-I-E-L-G-E-L-S-K-Y-L-G-A-K-F-T


### FUNCTION Binds 16S rRNA, required for the assembly of 30S particles ### SEQUENCE -M-L-K-Q-S-G-H-K-H-G-K-L-L-K-I-L-K-H-N-K-P-K-E-R-K-F-G-K-G-A-R-R-C-E-R-C-G-R-Y-D-G-I-I-R-R-Y-G-L-Y-L-C-K-D-C-F-K-E-V-A-H-E-L-G-F-F-K-W-G-E


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit ### SEQUENCE -M-W-R-Q-R-R-K-W-E-G-P-S-H-P-W-Q-K-Q-R-L-I-I-E-K-R-L-M-K-E-Y-G-L-K-N-K-R-E-L-W-I-A-E-T-I-A-R-K-W-R-A-Y-A-R-Y-L-N-A-K-Q-A-A-G-Q-D-I-S-E-E-K-E-R-F-L-T-K-L-K-K-L-G-V-L-S-E-N-A-E-L-D-D-V-L-D-L-T-V-K-D-V-L-E-R-R-L-Q-T-M-L-V-R-K-G-L-A-K-T-M-K-Q-A-R-Q-F-I-V-H-G-H-I-M-V-N-G-E-V-V-D-A-P-S-Y-L-V-K-K-E-E-E-D-K-I-E-F-V-P-F-S-P-L-A-N-P-E-H-P-A-R-K-L-E-Q-K-E-E-T-N-E-E-S-A


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-A-R-D-I-V-A-D-F-L-S-H-L-T-N-V-R-R-K-G-E-D-K-T-A-F-F-P-V-S-N-L-I-I-K-L-V-E-I-M-K-R-E-G-Y-I-K-N-Y-R-L-V-D-S-S-R-G-K-I-I-E-I-E-L-S-E-Y-F-N-E-A-N-A-I-K-P-R-F-P-V-E-Y-S-E-L-E-K-Y-E-K-R-Y-L-P-A-L-N-F-G-R-L-I-L-S-T-S-K-G-L-I-T-N-R-E-A-K-E-Q-K-I-G-G-V-L-I-A-Y-V-Y


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-K-L-A-E-L-I-E-L-P-K-E-Q-C-N-D-K-K-C-P-H-H-G-H-L-K-V-R-G-F-F-F-K-G-K-V-I-K-K-S-D-N-K-T-V-K-I-E-I-I-R-Y-Y-W-L-P-K-Y-E-R-Y-E-L-R-R-T-R-I-T-A-Y-L-P-E-C-L-K-D-I-K-E-G-D-Y-V-L-I-G-E-T-R-P-L-S-K-T-K-H-F-V-V-L-G-K-L-K-K-G-I-A-L-T-Q


### FUNCTION Catalyzes the reduction of arsenate ### SEQUENCE -M-E-N-K-K-T-I-Y-F-L-C-T-G-N-S-C-R-S-Q-M-A-E-A-W-G-K-K-Y-L-G-D-K-W-N-V-L-S-A-G-I-E-A-H-G-V-N-P-N-A-I-K-A-M-K-E-V-D-I-D-I-T-D-Q-T-S-D-I-I-D-R-D-I-L-D-K-A-D-L-V-V-T-L-C-G-H-A-N-D-V-C-P-T-T-P-P-H-V-K-R-V-H-W-G-F-D-D-P-A-G-Q-E-W-S-V-F-Q-R-V-R-D-E-I-G-A-R-I-K-K-Y-A-E-T-G-E


### FUNCTION Involved in succinate export with YjjP Both proteins are required for export ### SEQUENCE -M-G-V-S-L-L-W-A-L-L-Q-D-M-V-L-A-A-I-P-A-L-G-F-A-M-V-F-N-V-P-V-R-A-L-R-Y-C-A-L-L-G-A-I-G-H-G-S-R-M-L-M-I-H-F-G-M-N-I-E-L-A-S-L-V-A-S-I-M-I-G-I-N-W-S-R-W-L-L-A-H-P-K-V-F-T-V-A-A-V-I-P-M-F-P-G-I-S-A-Y-T-A-M-I-S-V-V-E-I-S-H-L-G-Y-S-E-A-L-M-S-T-M-V-T-N-F-L-K-A-S-F-I-V-G-A-L-S-I-G-L-S-L-P-G-L-W-L-Y-R-K-R-P-G-V


### FUNCTION Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition  system CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion Protects cells against the CDI activity of CdiA, its cognate toxin protein, but not against non-cognate CdiA from Ecoli strains 563, EC93 or Ddadantii strain 3937 ### SEQUENCE -M-K-N-L-L-Y-V-V-L-L-M-A-V-C-I-L-G-L-L-I-V-G-T-I-F-Y-L-F-L-E-V-F-M-Y-F-Y-V-N-A-P-I-S-L-E-S-F-Q-F-T-R-L-L-K-M-S-I-Y-G-G-G-I-L-G-L-G-I-G-L-L-R-I-F-K-I-K-G-F


### FUNCTION Participates in cysteine desulfuration mediated by SufS Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process ### SEQUENCE -M-A-G-L-P-D-R-D-K-L-I-R-N-F-S-R-C-L-N-W-E-E-K-Y-L-Y-I-I-E-L-G-G-Q-L-A-P-L-T-E-Q-Q-R-H-P-E-N-L-I-S-G-C-Q-S-Q-V-W-I-A-M-T-L-S-A-E-G-H-V-I-F-A-G-D-S-D-A-A-I-V-K-G-L-V-A-V-V-F-I-L-Y-H-D-L-T-P-Q-Q-I-I-S-L-D-V-R-P-F-F-A-D-L-A-L-S-Q-H-L-T-P-S-R-S-Q-G-L-E-A-M-I-R-A-I-R-T-K-V-A-N-L-S-A-H


### FUNCTION Involved in resistance toward heavy metals ### SEQUENCE -M-S-D-S-D-A-M-T-D-P-N-A-V-S-Y-S-N-A-I-V-V-L-C-T-A-P-D-E-A-S-A-Q-N-L-A-A-Q-V-L-G-E-K-L-A-A-C-V-T-L-L-P-G-A-T-S-L-Y-Y-W-E-G-K-L-E-Q-E-Y-E-V-Q-L-L-F-K-S-N-T-D-H-Q-Q-A-L-L-T-Y-I-K-Q-H-H-P-Y-Q-T-P-E-L-L-V-L-P-V-R-D-G-D-K-D-Y-L-S-W-L-N-A-S-L-L


### FUNCTION The GINS complex plays an essential role in the initiation of DNA replication ### SEQUENCE -M-G-Y-Y-D-L-D-D-I-L-A-D-S-S-K-F-A-C-R-F-N-Y-E-L-P-G-L-G-Y-L-E-G-N-P-G-K-P-V-G-K-H-S-K-V-E-L-P-L-W-L-A-S-V-L-A-T-V-T-G-E-Q-E-H-V-D-E-E-A-L-P-F-V-E-F-L-P-P-E-M-F-S-A-R-V-V-N-A-I-K-A-D-A-P-T-L-D-V-H-S-I-N-G-H-F-Y-A-L-G-T-R-W-A-A-L-F-S-D-A-G-L-A-G-M-L-A-G-M-V-L-E-R-A-L-E-V-Q-R-H-A-A-S-A-A-V-E-A-T-A-P-T-D-A-T-A-R-M-L-Q-T-L-D-E-W-E-R-Q-L-Y-R-R-A-H-A-A-S-R-D-A-K-L-W-A-A-R-R


### FUNCTION Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein  residues may serve to stabilize the conformation of rRNAs The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA ### SEQUENCE -M-H-L-M-Y-T-L-G-P-D-G-K-R-V-Y-T-L-E-K-V-T-P-S-G-E-I-T-K-S-A-H-P-A-R-F-S-P-D-D-K-Y-S-R-Q-R-V-T-L-K-R-R-F-D-M-L-P-R


### FUNCTION Component of the signal peptidase complex  which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum Dispensable for SPC enzymatic activity ### SEQUENCE -M-E-I-F-N-D-L-S-R-K-L-V-F-P-I-D-Y-P-S-Q-R-R-V-A-K-L-T-D-I-I-L-G-S-G-T-L-V-S-C-L-L-G-F-Y-A-G-S-L-S-L-T-L-Y-A-F-A-A-A-Y-G-L-A-L-L-L-V-V-P-A-Y-G-K-Y-R-Q-Q-K-L-A-W-V-G-S-A-A-A-T-T-K-D-L


### FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors ### SEQUENCE -M-S-N-Q-V-L-L-D-K-L-D-R-T-T-E-S-L-S-Q-A-L-A-Q-L-V-K-L-S-S-I-D-R-A-S-A-D-S-D-G-D-N-D-G-T-T-D-S-I-T-S-V-A-T-N-G-V-M-M-V-H-A-H-T-T-Q-L-I-R-G-V-Q-D-L-L-V-I-T-R-A-I-R-E-T-W-V-L-G-Q-I-P-K-K-N-G-D-E-D-A-I-D-Y-E-K-C-E-R-L-L-E-K-A-M-D-D-F-F-G-P-V-A-L


### FUNCTION Required for efficient biogenesis of the 60S ribosomal subunit ### SEQUENCE -M-S-T-E-I-S-A-A-A-P-R-R-A-A-N-G-K-K-R-A-N-R-R-K-K-R-R-T-Q-A-E-S-D-S-S-D-S-S-D-S-S-E-S-S-Q-P-S-A-D-E-Q-E-A-K-T-D-D-V-A-V-E-L-S-D-V-E-L-S-D-S-E-N-K-T-V-S-H-S-E-K-L-D-D-E-S-K-A-K-L-K-S-I-Q-L-T-A-T-D-L-S-S-K-F-A-L-Q-Q-N-R-N-I-D-L-Q-K-A-G-R-E-V-D-H-G-L-E-K-L-A-K-L-D-A-Q-T-S-E-Q-E-S-G-R-L-K-T-G-Y-I-N-M-L-F-E-H-V-G-E-D-V-N-Q-L-R-N-A-P-D-F-T-P-K-S-L-V-V-L-A-N-A-L-K-D-G-G-D-M-F-D-I-E-S-L-R-A-L-V-D-N-K


### FUNCTION Component of the general transcription and DNA repair factor IIH  of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription ### SEQUENCE -M-P-R-A-R-K-G-A-L-V-Q-C-D-P-S-I-R-A-L-I-L-Q-I-D-S-G-T-H-D-I-I-W-E-E-L-D-E-T-H-L-L-V-D-P-A-K-V-S-Y-I-K-E-K-L-N-W-F-L-S-K-N-I-Y-N-P-S-E-E-E-E-N-P


### FUNCTION Golgi membrane protein involved in vesicular trafficking ### SEQUENCE -M-S-E-N-D-Q-K-G-V-K-F-I-R-A-L-L-V-T-T-G-A-V-A-T-L-G-F-L-V-Q-L-S-E-V-A-S-E-F-L-A-A-A-R-A-C-F-G-L-P-L-S-V-L-L-V-Y-L-E-F-R-P-V-P-L-L-Q-Q-Y-A-S-F-Y-Y-S-Y-M-G-R-A-L-L-Q-L-L-L-A-V-M-L-L-P-A-G-F-F-Q-V-C-A-F-T-M-L-F-M-T-G-F-I-C-A-A-L-E-L-S-S-S-A-P-E-L-P-S-F-R-N-D-G-R-A-L-S-I-G-A-E-E-D-D-D-M-I


### FUNCTION Stimulates the activity of serine palmitoyltransferase ### SEQUENCE -M-M-A-A-D-D-T-M-S-S-K-R-A-D-N-C-Y-K-K-D-R-G-T-M-V-Y-T-P-T-D-A-Q-Q-A-T-G-K-V-H-E-K-V-Y-K-F-F-E-S-L-Y-W-M-Y-Y-I-H-L-P-Y-Y-L-M-T-S-F-D-S-F-C-L-H-V-F-F-L-V-V-F-T-L-S-L-F-G-L-L-K-W-V-L-S-L-Y-W-A-T-V-G-Y-M-A-Y-A-A-T-G-Q


### FUNCTION Golgi membrane protein involved in vesicular trafficking ### SEQUENCE -M-A-L-S-W-K-S-F-V-N-V-P-G-I-L-A-D-L-R-S-F-N-F-S-V-Y-G-R-W-F-G-Y-I-N-I-L-L-C-L-A-L-G-I-A-N-I-F-H-F-S-I-V-I-A-F-A-I-V-A-I-V-Q-G-L-L-L-I-F-V-E-V-P-I-L-L-K-I-C-P-L-S-D-N-F-I-G-L-V-K-K-C-D-T-N-G-R-R-T-L-L-Y-T-A-L-A-I-V-Q-Y-A-S-L-S-V-Q-V-T-S-L-L-A-V-A-I-G-L-T-I-S-A-I-F-Y-G-T-G-Y-L-K-K-Q-E-F-L-E-G-N-V-I-R-N-P-T-D-P-A-F-M-R-E-A-A-V-R-E-V-L


### FUNCTION Component of the COP9 signalosome ### SEQUENCE -M-I-R-Q-E-V-L-H-A-V-L-D-P-K-A-V-H-F-K-Q-F-W-L-S-S-V-D-R-D-E-S-E-L-L-E-V-L-C-F-G-N-Y-G-D-L-N-A-I-Q-S-C-E-E-W-K-D-A-I-E-S-K-L-R-T-L-T-L-L-G-L-C-E-V-P-S-E-L-E-Y-D-Q-A-M-A-S-C-C-I-P-D-D-V-I-L-E-Q-R-M-V-E-L-Q-A-Q-V-H-F-Q-L-D-S-V-G-R-R-I-K-V-L-R-C-L-G-A-R-D-I-Y-N-G-E-R-P-L-L-L-L-R-D-A-A-R-S-R-E-S-T-L-A-G-L-R-Q-W-K-Q-K-L-Q-Y-Q-L-R


### FUNCTION Involved in pre-mRNA splicing ### SEQUENCE -M-T-T-S-H-R-P-Q-L-E-A-R-S-G-T-K-S-G-V-A-G-E-Y-V-P-T-G-V-K-H-A-R-L-L-P-G-H-R-T-V-K-R-R-R-E-G-G-A-T-A-E-D-E-E-R-E-R-A-G-A-E-T-R-T-V-D-C-N-E-G-T-D-E-L-A-G-E-G-R-S-A-G-S-G-D-G-D-E-A-S-S-A-E-D-S-S-D-A-D-D-E-D-D-V-D-N-P-E-E-L-R-R-E-L-E-A-L-R-A-S-K-T-G-A-K-T-G-A-K-T-G-A-K-T-G-E-K-G-A-G-G-G-G-W-R-A-G-A-V-F-G-R-Q-K-R-R-R-E-Q-A-E-G-R-A-Y-R-N-D-V-T-Q-S-E-Y-H-Q-D-F-L-R-R-L-T-K


### FUNCTION As part of the CRL3 E3 ubiquitin ligase complex ### SEQUENCE -M-T-P-T-S-H-V-T-L-V-S-S-D-G-K-S-F-E-V-P-R-E-R-A-M-L-S-P-T-L-A-K-M-L-D-S-S-F-A-E-A-K-E-A-K-V-T-L-P-T-I-E-S-S-M-L-A-K-V-V-E-Y-L-E-Y-L-E-E-Y-K-H-K-D-D-G-E-D-I-P-Q-F-E-V-P-P-E-I-S-L-E-L-L-L-A-A-D-Y-L-Q-I


### FUNCTION Involved in pre-mRNA splicing May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome May do so by stabilizing the catalytic center or the position of the RNA substrate ### SEQUENCE -M-S-Y-N-G-I-G-L-K-T-A-K-G-S-S-T-S-G-H-I-Q-R-S-L-A-D-N-Q-A-G-N-V-K-N-F-S-S-R-K-E-E-S-Q-G-R-V-A-R-A-S-R-E-R-K-L-D-G-S-M-A-A-H-A-D-R-R-E-I-E-V-R-V-S-E-L-R-D-E-L-E-D-A-D-I-D-A-E-E-I-E-R-R-C-E-Q-L-R-R-Q-L-Q-S-E-A-A-E-R-A-R-V-A-Q-A-Y-T-P-R-N-A-R-S-A-G-A-T


### FUNCTION Component of the ceramide synthase complex required for synthesis of ceramides ### SEQUENCE -M-A-I-G-R-Y-G-T-L-V-F-Y-I-L-A-G-L-A-F-V-W-S-L-E-Y-F-K-H-Y-T-K-N-N-Y-E-R-F-H-C-T-A-V-V-E-P-V-Q-G-T-A-T-V-E-K-L-S-A-V-G-G-P-P-C-D-K-R-A-E-L-K-L-I-T-Q-K-L-T-Q-H-F-D-P-N-K-Q-P-A-L-F-C-I-V-E-N-T-S-V-E-S-V-H-Y-P-V-S-R-T-N-K-G-P-A-G-Y-I-A-Y-A-G-Y-E-A-D-R-A-A-V-H-K-Y-C-E-A-H-G-A-A-V-L-H-M


### FUNCTION Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane ### SEQUENCE -M-S-G-Q-L-E-V-S-A-P-S-R-S-I-L-N-D-K-W-D-V-V-L-S-N-L-V-V-K-T-G-L-G-F-G-A-G-V-F-A-S-V-L-F-F-K-R-R-A-F-P-V-W-L-G-V-G-F-G-L-G-R-G-Y-A-E-G-D-A-I-F-R-S-H-A-G-L-R-A-V-R-A


### FUNCTION Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase , that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c ### SEQUENCE -M-P-Q-S-F-S-S-I-V-R-M-G-D-Y-I-L-K-S-P-T-L-S-K-I-A-V-P-V-A-Q-Q-F-V-K-L-S-G-Y-R-Q-L-G-L-K-F-D-D-L-I-A-E-E-N-D-I-V-Q-T-A-L-R-R-L-P-E-E-E-S-Y-A-R-V-F-R-I-I-Q-A-H-Q-L-E-L-T-H-H-L-L-P-K-H-K-W-T-K-P-E-E-D-K-S-Y-L-L-P-Y-L-L-E-A-E-A-A-A-K-E-K-L-E-L-D-A-L-E-L-K


### FUNCTION Plays an essential role in the assembly of succinate dehydrogenase  to ubiquinol Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants May act together with SDHAF1 ### SEQUENCE -M-R-T-T-N-H-L-Y-R-T-V-H-R-Q-G-K-P-L-L-P-P-L-H-L-Y-R-R-I-L-R-A-H-R-T-F-P-P-A-Q-R-A-L-G-D-E-Y-V-K-S-E-F-K-L-H-K-N-I-D-N-P-V-H-I-I-G-F-L-A-S-W-Q-D-Y-F-H-M-I-S-T-N-S-W-A-E-G-T-L-S-K-S-L-V-D-Q-M-S-S-E-Q-I-V-Q-L-Y-E-L-M-K-E-T-K-Q-L-G-G-A-S-A-E-S-G-S-S-L-S


### FUNCTION Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 ### SEQUENCE -M-D-G-S-H-Y-D-I-L-G-I-A-V-D-A-E-P-L-E-V-R-Q-A-Y-R-Q-R-L-L-E-A-H-P-D-K-Q-G-G-V-D-K-G-A-V-T-R-I-Q-Q-A-Y-R-V-L-S-D-P-T-Q-R-S-A-Y-D-G-E-L-A-V-Q-I-A-A-T-G-V-H-G-R-A-D-A-L-D-E-H-S-L-D-D-F-E-Y-N-E-Q-Q-G-V-F-T-M-A-C-P-R-C-S-S-A-E-G-F-E-L-P-E-Q-A-L-E-E-N-A-T-A-R-P-G-G-G-M-Q-V-I-V-Q-C-A-A-C-S-L-W-L-K-V-D-F-D-I-V-Y-T-S-E


### FUNCTION Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane ### SEQUENCE -M-P-R-L-L-R-Y-G-S-F-S-V-V-A-S-V-L-G-A-S-Y-Y-Y-Y-A-V-A-S-P-L-Y-T-E-A-E-W-H-R-V-S-Q-R-T-A-A-L-I-D-R-R-I-D-I-P-V-P-E-S-T-T-E-R-R-E-Y-V-V-R-S-S-K-E-T-M-K-D-I-W-N-E-Q-I-R-S-I-V-D-W-I-Y-S-W-S-H


### FUNCTION Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP  pathway ### SEQUENCE -M-S-S-D-W-D-T-N-T-V-I-G-Q-R-V-R-T-G-G-S-G-P-R-Q-Q-V-A-R-T-Q-G-Q-I-N-A-A-R-R-A-G-L-V-L-S-V-D-K-K-Y-A-S-S-N-T-K-A-N-N-E-G-Q-R-L-T-M-V-D-R-E-T-D-I-V-K-P-K-K-L-D-P-S-V-G-R-A-I-A-K-G-R-G-D-K-G-M-T-Q-K-D-L-A-T-R-I-N-E-K-P-T-V-I-N-D-Y-E-A-G-R-A-I-P-N-Q-Q-I-L-A-K-M-E-R-A-L-G-V-K-L-R-G-K-G-I-G-E-P-L-G-G-P-K-K-K


### FUNCTION Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit ### SEQUENCE -M-A-V-K-N-L-E-K-G-I-N-V-S-G-R-V-W-K-S-E-K-D-A-F-R-A-T-S-K-V-I-K-N-K-K-L-T-S-W-E-L-K-R-E-Q-R-Q-L-D-Q-Q-F-K-E-R-M-N-A-L-K-N-E-K-E-E-E-R-Q-Q-R-I-K-A-L-R-E-R-R-E-K-K-E-E-K-E-R-Y-E-R-L-A-A-R-M-H-A-K-K-V-E-R-M-R-R-R-E-K-R-N-K-A-L-K-E-R


### FUNCTION The complex LTO1YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly  complex machinery May be required for biogenesis of the large ribosomal subunit and initiation of translation ### SEQUENCE -M-S-C-E-D-D-W-L-N-T-S-D-D-E-E-K-H-G-V-F-G-G-G-S-L-E-L-Q-K-L-E-R-T-H-R-N-R-G-Y-R-D-G-I-S-S-A-K-E-E-N-L-Q-E-G-F-D-M-K-F-P-E-G-S-R-L-G-F-Q-V-G-E-V-I-G-K-L-Q-T-L-D-S-L-F-G-A-Q-D-S-E-L-R-S-D-Y-K-E-A-L-A-Q-L-Q-I-S-R-V-L-T-H-A-N-F-S-E-Q-M-D-A-T-E-A-L-S-S-L-L-A-R-W-E-G-A-L-V-K-Y-T-S-R-Y-I-P-N-V


### FUNCTION Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 ### SEQUENCE -M-S-T-S-S-R-A-L-A-A-Y-R-N-A-L-R-A-T-K-V-A-F-G-E-D-V-R-M-L-V-A-A-R-K-A-M-R-H-G-M-L-A-P-D-A-S-L-P-V-E-D-Q-I-T-H-M-N-D-I-A-T-F-L-R-R-N-L-V-Q-G-K-K-V-S-G-K-D-D-V-Y-Q-L-R-I-H-E-E-T-E-L-G-D-N-A-T-I-K-E-T-K-T-T-L-A-S-Q-G-G-G-C-C-G-G-G-K-D-L-Y-K


### FUNCTION Involved in pre-mRNA splicing ### SEQUENCE -M-G-I-E-D-I-N-R-R-L-R-Q-L-K-K-K-R-V-D-A-S-I-R-N-R-K-E-A-A-S-E-E-R-A-R-L-A-E-G-K-P-R-V-Y-S-M-A-E-E-P-A-D-E-A-E-A-D-D-T-Q-S-E-Q-L-K-L-L-N-Y-R-I-A-D-Y-E-K-W-D-E-K-Q-K-R-H-K-Q-P-S-D-G-A-D-L-G-E-L-A-N-S-T-Y-R-S-E-L-H-Q-L-H-R-R-G-V-V-K-G-R-A-T-N-G-R-I-S-A-S-G-K-V-V-L-D-D-E-P-E-L-V-E-K-L-A-A-A-V-Q-Q-T-A-K-R-R-H-E-E-R-Q-K-K-A-A-K-D-G-G-R-A-T-A-G-S-L-N-D-K-N-R-H-F-N-E-K-L-D-R-E-F-R-K-R-G-Q


### FUNCTION Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 ### SEQUENCE -M-D-H-T-L-H-L-H-V-P-F-E-S-A-R-L-A-D-I-A-A-R-A-L-A-P-D-P-L-L-R-P-E-E-L-S-V-S-F-A-S-D-G-A-S-L-N-I-K-L-A-A-I-D-A-R-V-L-R-V-A-T-N-S-I-F-E-A-L-K-T-V-V-E-T-A-D-E-L-D-F


### FUNCTION May be involved in cellular response to stress Required to maintain mitochondrial DNA ### SEQUENCE -M-S-S-F-F-K-F-Y-K-A-S-L-Q-S-H-P-K-R-T-N-A-L-T-T-G-F-L-F-G-L-G-D-I-V-A-Q-T-Q-F-P-E-P-G-A-S-Y-D-P-M-R-T-L-R-P-F-L-Y-G-A-V-L-F-S-L-V-G-D-K-W-Y-R-F-L-S-T-V-R-L-G-R-L-P-Q-A-H-W-A-N-V-L-A-R-V-A-C-D-Q-L-I-F-A-P-I-G-V-P-L-Y-Y-T-A-M-A-L-M-E-G-G-S-L-E-D-V-R-I-R-L-S-E-K-W-W-S-T-L-L-A-N-W-I-V-W-P-A-F-Q-L-C-N-F-S-L-V-P-V-Q-H-R-L-L-T-V-N-V-L-S-I-F-W-N-T-Y-L-S-Y-S-N-S-T-A-S-S


### FUNCTION Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner In the complex, it is required to regulate activity of mtHSP70 ### SEQUENCE -M-A-H-R-V-L-V-Q-V-I-F-T-G-A-R-V-F-G-R-A-F-T-E-A-Y-K-Q-T-A-A-Q-M-A-K-Q-G-T-S-S-A-A-R-S-Q-G-G-M-T-N-E-Y-G-G-I-T-L-D-E-S-C-K-I-L-N-I-E-E-N-G-P-E-M-N-L-D-K-V-E-Q-R-F-K-Y-L-F-D-I-N-D-K-E-K-G-G-S-F-Y-L-Q-S-K-I-Y-R-A-A-E-R-L-K-W-E-L-A-Q-R-E-Q-A-D-K-G-A-S-A-H-P-Q-D-Q-Q-P-G-P-Q-N


### FUNCTION Component of the biogenesis of lysosome-related organelles complex-1  involved in endosomal cargo sorting ### SEQUENCE -M-S-D-D-V-D-S-E-T-R-S-R-T-P-S-I-S-S-R-Q-F-I-I-P-E-D-E-L-A-T-L-D-S-E-N-S-S-L-D-S-G-G-E-E-A-S-S-G-G-S-D-A-Y-S-A-A-G-G-S-T-P-V-F-S-R-L-G-Q-H-P-S-T-F-F-T-G-S-Q-V-A-P-I-F-D-T-S-L-Y-L-F-E-S-L-T-Q-S-L-D-S-V-D-F-S-E-A-L-S-L-Q-T-K-T-S-A-T-I-N-S-K-S-R-E-L-Q-L-L-V-G-E-V-Q-T-H-L-R-R-L-Q-T-A-F-E-Q-G-Q-H-T-A-Q-R-V-R-H-N-L-R-D-I-T-R-G-V-E-S-L-K-Q-T-F-A-R-S-Y-P-I-E-Y-H-Q-A-L-E-R-A-Y-E-R-R-A-E


### FUNCTION Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit Accompanies the pre-60S particles to the cytoplasm ### SEQUENCE -M-P-S-K-N-S-I-N-R-P-K-Q-K-L-N-L-Q-H-R-V-Q-K-N-A-A-K-R-S-A-R-E-R-A-G-L-L-A-P-P-R-S-S-D-Q-S-Q-S-G-R-A-K-S-I-P-L-D-L-F-R-G-E-R-V-D-Q-G-P-I-T-T-K-T-L-S-K-K-R-A-K-K-I-E-R-N-L-R-Y-V-E-Q-R-K-L-L-V-D-V-Q-A-A-R-E-S-G-M-D-I-D-V-E-T-A-V-S-T-K-A-K-T-Q-Q-T-G-P-L-Q-K-V-K-E-S-I-W-S-A-L-E-D-V-A-A-Q-E-M-I-V-Q-T-G-A-G-T-T-L-G-G-Q-F-F-P


### FUNCTION Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules ### SEQUENCE -M-S-L-L-R-T-L-Q-M-Q-P-R-V-I-T-V-F-A-E-H-A-N-V-G-A-A-S-E-I-L-G-A-L-K-T-A-S-G-P-K-C-K-V-Q-V-S-T-M-F-P-T-L-E-Q-L-I-Y-M-S-E-I-N-R-T-A-V-A-A-Q-V-P-R-L-S-E-L-L-Q-K-P-S-F-S-E-E-F-S-S-P-L-A-Q-C-T-Q-D-G-V-W-R-S-Q-G-G-L-W-V-D-W-E-K-R-L-L-G-A-D-G-Q-S-V-H-E-L-L-G-S-S-T-M-T-I-D


### FUNCTION Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation ### SEQUENCE -M-S-I-E-N-L-K-S-F-D-P-F-A-D-T-G-D-D-E-A-S-S-S-N-Y-I-H-I-R-I-Q-Q-R-N-G-R-K-T-L-T-T-V-Q-G-I-P-E-E-Y-D-L-K-R-I-L-K-V-L-R-K-D-F-G-C-N-G-N-M-V-K-D-D-E-M-G-E-I-I-Q-L-Q-G-D-Q-R-A-K-V-C-E-F-L-I-T-Q-L-A-I-P-K-K-N-I-K-I-H-G-F


### FUNCTION Involved in export of poly ### SEQUENCE -M-S-V-D-E-H-L-N-Q-G-T-G-E-K-Q-Y-R-R-R-D-L-R-N-G-L-A-S-R-M-G-L-G-E-S-T-Y-R-A-R-E-Y-G-P-S-R-R-S-R-F-R-D-R-R-D-A-R-P-P-P-P-T-H-Q-R-V-R-F-L-N-I-P-L-D-V-S-D-Y-E-I-D-D-L-L-K-D-L-P-K-P-L-Y-S-K-F-Y-D-H-E-D-S-R-S-A-V-F-E-F-E-D-H-S-I-L-D-K-C-V-E-L-Y-N-G-L-E-L-H-G-A-K-I-T-V-E-I-F-E-Q-Q-G-R-F-A-D-S-T-R-T-N-R-S-T-D-H-V-E-K-E-A-G-F-K-T-G-R-P-R-G-K-A-R-A-T-K-K-E-K-P-P-Q-P-T-L-E-D-L-D-A-E-L-D-A-Y-M-N-G-N


### FUNCTION Forms a chaperone-bound H2AZ-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2AZ histone replacement in chromatin ### SEQUENCE -M-A-E-K-A-A-E-K-A-E-Q-R-A-A-D-E-A-E-K-R-P-V-E-D-G-E-K-H-S-G-R-K-R-R-R-R-N-Y-D-E-H-D-E-A-V-A-K-D-D-A-Q-S-A-K-A-G-A-A-A-D-S-D-A-D-D-S-D-A-D-D-E-K-L-E-V-L-M-A-R-E-E-E-D-E-D-D-L-A-E-I-D-A-S-N-I-I-S-G-G-R-R-T-R-G-K-V-I-D-Y-K-Q-T-A-E-E-L-A-A-E-G-A-A-A-G-V-D-D-D-A-E-D-A-D-A-D-F-D-G-E-G


### FUNCTION Component of the biogenesis of lysosome-related organelles complex-1 , a complex involved in endosomal cargo sorting ### SEQUENCE -M-N-P-S-E-V-A-S-A-G-I-H-P-I-E-L-C-V-H-S-I-L-S-S-N-L-E-G-I-Y-Q-A-I-T-E-L-R-E-S-Q-A-L-L-V-M-K-F-N-Q-V-K-K-S-F-M-D-E-Q-E-L-L-Q-E-E-G-S-L-K-E-E-L-A-R-V-N-Q-L-K-K-R-L-D-K-L-T-E-L-Y-A-E-L-A-R-K-C-G-A-L


### FUNCTION Plays a role in starvation-induced autophagy Involved in mitophagy Functions with ATG17 and ATG29 at the preautophagosomal structure ### SEQUENCE -M-E-P-F-V-I-T-A-S-E-C-D-C-N-S-A-H-S-S-R-V-S-K-D-G-Y-A-L-S-D-E-L-S-N-E-T-M-F-L-T-Q-V-K-Y-I-F-E-G-E-E-D-H-I-D-D-N-T-M-Q-E-I-N-T-D-I-V-N-V-V-I-V-E-L-D-E-T-L-E-I-K-N-V-E-L-I-S-D-E-Y-Q-L-L-G-F-S-N-D-A-D-N-D-L-N-L-T-I-L-S-E-F-P-A-D-V-S-P-G-T-R-D-L-G-K-L-V-T-R-Y-Q-H-Q-N-K-H-L-K-H-M-L-Q-E-L


### FUNCTION Involved in ribosome biogenesis, probably through modulation of rDNA transcription ### SEQUENCE -M-K-Q-R-V-A-V-R-E-R-D-R-L-Q-E-K-E-R-L-R-R-Q-R-Q-R-A-E-R-E-A-R-Q-Q-A-S-Q-A-E-Q-E-A-K-L-A-A-L-E-R-H-Q-E-T-G-R-L-T-K-E-E-K-R-Y-L-N-K-R-T-R-Q-G-A-A-R-A-R-T-W-D-L-D-E-D-E-A-D-E-A-A-A-L-Q-S-Q-I-L-D-R-I-G-S-A-S-G-A-G-R-V-R-K-Q-R-R-A-R-I-R-E-A-L-P-K-A-S-E-D-R-R-Y-A-G-L-T-P-G-L-A-P-V-G-M-S-D-E-E-S-S-D-E-E-L-S-D-E-E-D


### FUNCTION Acts as an inhibitor of cap-dependent translation Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA ### SEQUENCE -M-A-K-Y-T-E-E-E-L-L-Q-L-K-P-T-Y-D-V-A-V-N-F-D-V-D-A-F-K-A-M-I-A-E-V-A-E-H-H-E-I-A-D-L-F-H-Q-K-A-R-R-R-S-S-H-H-H-G-V-K-P-K-I-K-A-H-K-P-R-I-T-T-D-D-D-G-W-C-T-S-T-R-K-T-S-V-V-A-V-G-D-D-G-E-P-S-P-A-F-V-A-Q-E-T-L-R-V-K-P-N-N-K-N-I-A-S-S-R-P-A-D-T-R-D-I-V-A-D-K-P-T-M-S-F-N-A-F-A-A-L-E-S-D-D-E-D-Q-F


### FUNCTION Component of the biogenesis of lysosome-related organelles complex-1 , a complex that is involved in endosomal cargo sorting ### SEQUENCE -M-V-A-E-A-G-A-S-I-Q-A-E-D-V-N-N-D-P-F-R-V-D-Q-L-I-L-D-Y-D-Y-M-L-Y-R-I-K-D-H-V-A-S-I-H-L-A-T-T-E-L-C-R-K-Q-N-Q-L-V-C-T-G-I-V-E-E-I-I-D-S-N-I-K-N-V-R-E-L-L-T-K-C-K-E-L-E-T-Y-F-E-Q-L-H-A-I-D-G-I-V-S-T-F-H-E-R-M-D-E-I-V-K-Q-Y-R-D-I-K-V-H-T-D-S-A-S-R-D-H-V-A-T-K


### FUNCTION Plays an essential role in the assembly of succinate dehydrogenase  of the flavoprotein subunit of the SDH catalytic dimer ### SEQUENCE -M-L-R-F-S-F-S-H-A-F-A-G-S-Y-G-L-A-P-A-R-A-T-R-F-Y-P-R-I-L-P-F-A-A-R-A-Y-S-A-D-K-Q-G-D-D-V-I-L-R-V-K-V-A-P-I-K-R-N-N-E-T-L-E-Q-Q-R-A-R-L-V-Y-Q-S-R-K-R-G-I-L-E-T-D-L-L-L-S-G-F-A-A-K-Y-L-K-H-M-T-A-E-E-L-N-E-Y-D-E-L-L-N-E-L-D-W-D-I-Y-Y-W-A-T-K-N-S-D-A-S-P-L-P-E-K-W-Q-H-S-K-I-L-R-K-L-Q-A-Y-S-E-N-K-D-K-Q-I-L-K-M-P-D-L-S-E-F


### FUNCTION Involved in mitochondrial genome encoded proteins translation ### SEQUENCE -M-P-G-R-T-P-T-Y-K-L-P-P-L-P-R-L-K-V-K-K-P-V-I-K-Q-E-A-N-R-C-L-V-L-M-S-N-L-L-Q-C-W-S-S-N-G-H-M-N-P-V-C-E-K-L-A-T-D-L-K-A-C-T-S-Q-N-V-M-G-S-N-Q-K-P-R-K-S-T-I-N-Y-H-A-A-R-L-Y-D-R-I-S-G-K-P-H-D


### FUNCTION Mediates the nuclear localization of the ribonucleotide reductase ### SEQUENCE -M-C-L-Y-V-N-K-E-H-P-Y-T-Q-A-S-G-P-W-P-A-C-L-P-R-R-W-Q-L-Y-K-D-Q-R-R-L-H-R-P-G-G-R-R-P-M-S-T-S-D-S-H-L-G-S-P-R-K-R-Q-L-Q-R-A-A-P-A-A-P-Q-H-S-E-Y-Q-Q-Q-L-S-T-L-G-M-R-I-R-Q-A-V-D-N-G-Y-R-A-P-Q-D-P-V-R-A-A-V-P-H-A-V-P-A-A-A-C-V-Q-D-N-T-L-Y-T-V-P-D-Y-K-R-V-P-L-A-A-D-R-A-P-P-M-L-V-N-Q-R-T-V-S-S-T-S-S-L-Q-A-W-E-S-Q-L-D-E-R-L-S-L-I-D-S-S-I-M-H-N-K-L-G-A-G-E-F-M-L-G-G-T-K-R-A-F-D-Q-L-E-T-D-N-W


### FUNCTION Component of the biogenesis of lysosome-related organelles complex-1 , a complex involved in endosomal cargo sorting ### SEQUENCE -M-E-L-D-Q-D-V-N-R-I-I-K-S-K-T-A-T-K-V-S-A-M-Q-A-E-I-E-A-N-H-A-Y-I-Y-D-V-Q-L-K-K-L-L-R-L-H-D-E-E-L-Q-E-R-C-H-T-P-L-R-K-L-Y-A-K-Y-S-S-R-A-E-G-N-R-D-L-Q-T-W-A-E-H-V-E-R-D-L-R-L-L-E-T-T-L-R-L-V-R-E-G-K-A-Q-D-T-E-Q-A-P-G-K-G-D-R-I-F-R-S-D


### FUNCTION Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling ### SEQUENCE -M-E-Y-K-Y-N-V-T-L-L-L-L-Q-V-V-L-H-R-Q-Q-E-L-A-H-Q-D-K-T-L-S-Q-I-S-L-L-R-E-P-V-V-D-T-A-V-L-E-R-F-S-A-H-R-V-V-R-L-Y-A-P-E-L-C-G-L-R-L-E-E-L-Q-A-V-V-R-E-V-F-A-R-G-L-A-G-S-A-E-D-T-P-V-T-L-I-T-L-A-N-H-Y-Y-R-L-R-V-Q-E-L-E-L-Q-E-L-P-K-L-K-E-L-M-E-S-A-A-G-L-R-T


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-D-A-L-N-S-R-E-Q-Q-E-F-Q-R-V-V-E-Q-K-Q-M-K-D-F-M-R-L-Y-S-N-L-V-E-R-C-F-S-D-C-V-N-D-F-T-S-S-K-L-T-S-K-E-Q-T-C-I-M-R-C-S-E-K-F-L-K-H-S-E-R-V-G-Q-R-F-Q-E-Q-N-A-A-L-N-Q-S-M-G-R


### FUNCTION Common component of the spliceosome and rRNA processing machinery In association with the spliceosomal U4/U6U5 tri-snRNP particle, required for splicing of pre-mRNA In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA ### SEQUENCE -M-S-S-T-P-N-P-K-A-F-P-L-A-D-A-A-L-T-Q-Q-I-L-D-V-V-Q-Q-A-S-N-M-R-Q-L-K-K-G-A-N-E-A-T-K-T-L-N-R-G-I-S-E-F-I-I-M-A-A-D-C-E-P-I-E-I-L-L-H-L-P-L-L-C-E-D-K-N-V-P-Y-V-F-V-P-S-R-V-A-L-G-R-A-C-G-V-S-R-P-V-I-A-A-S-I-T-T-N-D-A-S-A-I-K-S-Q-I-Y-A-V-K-D-K-I-E-T-L-L-I


### FUNCTION Required for assembly of cytochrome c oxidase ### SEQUENCE -M-L-E-P-S-R-Y-Q-D-P-R-T-W-K-M-T-P-A-M-I-R-A-R-R-P-Y-I-R-G-N-L-F-G-L-V-T-L-L-G-V-A-G-G-I-Y-V-Y-T-Y-R-A-L-H-K-D-D-D-F-A-D-V-P-I-P-P-V-S-E-E-E-L-R-Q-L-R-Q-E-Y-E-L-H-K-K-Q-R-A-A-E-R


### FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors ### SEQUENCE -M-D-Q-Q-D-L-N-K-L-Q-T-N-L-S-D-A-E-I-R-L-A-S-I-I-E-S-F-I-E-L-G-V-S-V-Y-D-F-P-G-T-Q-E-S-T-Q-G-M-V-T-N-L-K-R-N-V-E-R-I-K-L-L-N-Q-H-A-N-D-P-D-S-Q-L-R-N-M-N-I-P-L-E-V-L-Q-Y-I-E-D-G-R-N-P-D-V-Y-T-R-E-F-V-E-A-I-R-R-S-N-Q-Y-Q-R-A-K-M-H-A-L-K-K-L-R-D-S-L-A-E-K-I-G-E-E-F-P-D-L-V-P-Q-V-Q-G-I-I-E-R-A-N-G-S-R-D-K


### FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors ### SEQUENCE -M-P-Q-P-D-S-V-K-A-R-L-A-A-L-D-R-I-D-D-E-L-C-A-V-L-Q-H-A-Q-A-T-I-G-A-L-A-E-L-K-R-G-H-A-A-L-Q-P-Q-L-E-Q-H-V-R-D-Y-Y-R-T-L-E-H-S-T-V-A-L-R-N-E-I-R-E-L-D-A-A-V-G-T-Q-L-L-P-V-N-I-G-K-R-A-V-G-Q-D-Q-E-K-L-S-E-Q-L-A-Q-M-D-K-Y-V-G-S-M


### FUNCTION Involved in ribosome biogenesis Required for normal pre-rRNA processing in internal transcribed spacer 1 ### SEQUENCE -M-V-A-K-K-R-T-Q-L-R-A-K-A-M-R-Q-R-R-N-S-S-E-A-M-E-T-E-E-L-P-P-D-P-K-A-F-L-H-Q-L-R-E-S-K-R-E-K-Q-L-N-R-S-Q-S-F-L-N-R-L-R-D-Q-A-G-N-G-G-I-S-K-S-A-L-R-R-R-K-K-R-M-K-E-E-L-K-P-R-M-E-D-L-L-T-S-L-K-E-E-G-V-L-E-E-D-E-S-G-E-L-A-A-V-T-G-V-T-A-I-T-A-S-N-G-Y-S-G-L-H-D-T-A-E-A-C-G-T-V-R-I-R-K-N-E-P-S-I-R-T-Q-R-G-A-K-L-L-T-T-K-E-Q-E-R-F-T-K-V-I-S-N-E-R-F-R-S-S-P-F-E-T-L-R-E-I-I-K-S-R-K


### FUNCTION Involved in pre-mRNA splicing ### SEQUENCE -M-A-D-D-V-I-D-W-L-P-Y-V-D-T-L-D-Q-R-Y-L-N-E-V-E-K-T-V-T-A-E-L-A-A-I-E-Q-Q-E-L-H-P-R-I-A-E-L-F-P-A-V-R-H-H-W-D-E-Q-Y-G-L-Y-K-D-N-V-V-G-L-E-G-S-N-K-R-A-A-E-D-G-V-L-S-E-L-K-R-R-C-P-G-I-D-I-S-V-Y-N-D-D-S-E-D-P-V-L-L-A-T-I-A-G-Y-R-Y-H-Q-D-L-V-V-T-Q-L-L-P-Q-T-L-E-N-Q-W-A-I-N-N-A-Y-L-E-G-A-E-A-A-V-R-R-Q-L-Q-E-Q-E-Q-Q-I-A-Q-L-D-R-H-R-Q-E-L-Q-Q-R-E-A-L-R-F-R-Y-L-E-R-Q-W-R-D-R-L-H-G-N-L-E-R-A-A-G-N-I


### FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell The small ribosomal subunit , which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel ### SEQUENCE -M-S-A-K-A-Q-N-P-M-R-E-L-K-I-E-K-L-V-L-N-I-S-V-G-E-S-G-D-R-L-T-R-A-S-K-V-L-E-Q-L-S-G-Q-T-P-V-H-S-K-A-R-Y-T-V-R-T-F-G-I-R-R-N-E-K-I-A-V-H-V-T-I-R-G-P-K-S-E-E-I-L-E-R-G-L-K-V-K-E-Y-Q-L-R-T-K-N-F-S-E-T-G-N-F-G-F-G-I-Q-E-H-I-D-L-G-I-K-Y-D-P-S-I-G-I-Y-G-M-D-F-Y-V-V-M-G-R-P-G-G-R-V-S-R-R-K-R-C-R-S-T-V-G-N-S-H-K-T-S-K-E-D-T-I-A-W-F-K-Q-R-Y-D-A-D-V-L-D-K


### FUNCTION Involved in peroxisome biogenesis ### SEQUENCE -M-V-S-K-A-S-R-D-Q-L-R-K-Y-G-A-V-S-L-A-S-L-L-V-A-A-S-I-V-A-Y-R-W-W-N-A-A-P-S-I-E-V-E-K-K-L-R-R-S-V-S-R-C-V-V-V-T-Q-G-I-Q-N-E-D-M-I-H-D-L-L-F-E-D-T-V-M-L-L-A-P-G-C-T-A-E-G-R-L-K-S-A-S-R-E-N-A-Y-K-V-I-S-C-T-T-W-Q-S-V-W-A-C-V-R-H-F-R-K-H-T-L-L-V-R-T-S-E-V-P-S-G-V-P-A-D-I-G-G-Y-V-S-D-I-S-D-I


### FUNCTION Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner ### SEQUENCE -M-L-A-R-G-I-L-R-P-A-L-A-R-A-E-L-G-R-A-F-S-C-S-A-Q-W-Q-Q-A-A-G-S-T-S-G-R-E-L-S-W-P-D-F-F-A-L-R-K-T-E-R-R-I-N-T-G-S-S-V-L-T-A-F-L-T-A-N-C-A-W-A-Y-I-S-T-V-Q-I-D-V-T-Q-M-L-F-G-F-D-P-M-V-V-L-V-G-A-L-F-A-S-S-G-L-G-Y-L-C-G-P-L-M-G-S-A-F-F-R-V-K-H-R-G-Q-L-E-G-Y-N-H-K-N-R-V-F-L-E-H-I-K-K-N-R-V-D-A-S-S-Q-S-F-S-N-P-L-P-D-Y-Y-G-E-K-I-G-S-L-Q-E-Y-R-Q-W-L-R-D-C-Q-S-H-R-R-K-A-K-E-F-L


### FUNCTION Involved in spore wall assembly ### SEQUENCE -M-S-L-W-S-F-A-V-F-W-F-Y-L-A-S-F-F-V-V-G-T-L-A-A-V-L-V-L-P-F-M-A-A-S-L-L-F-A-T-G-V-V-I-C-G-F-F-S-N-L-S-F-R-S-A-Q-L-V-Y-D-Q-F-V-G-T-L-Q-L-T-L-Q-H-M-A-E-Q-V-P-P-A-S-D-M-Q-Q-P-S-G-S-T-I-D-T-G-A-M-L-A-H-T-F-D-S-S-S-Y-G-A-T-T-Q-T-G-S-G-P-E-S-G-P-V-P-E-L-G-S-E-V-S-A-S-P-S-P-E-L-A-A-L-P-V-A-H-K-R-S-G-R-R-T-G-T-L-A-S-G-M


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-F-G-L-G-G-Q-P-Q-L-S-S-Q-Q-K-I-A-A-A-E-A-E-L-D-L-V-T-D-M-F-N-K-L-V-S-N-C-H-R-K-C-I-D-M-N-Y-N-E-G-D-L-N-K-N-E-S-N-C-L-D-R-C-V-A-K-Y-F-E-T-N-V-K-V-G-E-N-M-Q-Q-L-G-Q-N-F-S-P-G-K-F


### FUNCTION Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body ### SEQUENCE -M-S-V-S-Y-N-G-G-L-T-G-L-T-A-L-V-R-N-N-L-V-H-Y-Q-Q-W-S-D-V-E-V-V-P-L-R-D-R-E-A-L-R-G-R-P-A-Q-K-L-S-N-D-D-E-E-I-G-V-E-Y-V-L-P-V-E-L-S-Q-Y-R-S-S-G-V-T-L-E-A-L-D-K-V-F-S-Q-L-P-A-S-C-K-R-V-V-L-A-I-S-S-D-D-G-T-V-V-Y-Y-T-V-Y-Q-G-L-Q-R-P-R-K-N


### FUNCTION GTP-binding protein involved in protein trafficking ### SEQUENCE -M-G-V-S-F-S-K-L-F-S-N-L-F-G-H-K-E-M-R-I-L-M-V-G-L-D-G-A-G-K-T-T-V-L-Y-K-L-K-L-G-E-V-V-T-T-I-P-T-I-G-F-N-V-E-T-V-E-Y-K-N-I-S-F-T-V-W-D-V-G-G-Q-D-K-I-R-P-L-W-R-H-Y-F-R-N-T-E-G-I-I-F-V-V-D-S-N-D-R-S-R-I-A-E-A-R-E-V-L-Q-R-M-L-N-E-D-E-I-R-N-A-V-L-L-V-F-A-N-K-Q-D-L-P-E-A-M-S-A-A-E-I-T-E-K-L-G-L-H-S-I-R-Q-R-P-W-Y-I-Q-A-T-C-A-T-S-G-E-G-L-Y-E-G-L-E-W-L-S-T-N-L-K-N-Q-A


### FUNCTION Facilitates protein transport into the nucleus Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import ### SEQUENCE -M-S-M-D-F-S-A-L-A-Q-Q-F-T-E-F-Y-Y-N-Q-F-D-T-D-R-S-Q-L-G-N-L-Y-R-D-Q-S-M-L-T-F-E-T-S-Q-L-Q-G-A-K-D-I-V-E-K-L-V-S-L-P-F-Q-K-V-Q-H-R-I-T-T-L-D-A-Q-P-A-S-P-N-G-D-V-L-V-M-I-T-G-D-L-L-I-D-D-E-Q-N-A-Q-R-F-S-Q-V-F-H-L-M-P-E-G-N-S-Y-Y-V-F-N-D-I-F-R-L-N-Y-S-A


### FUNCTION Involved in translation ### SEQUENCE -M-F-K-K-F-S-K-E-D-I-H-T-R-T-K-V-K-T-S-V-Q-R-S-L-K-S-K-L-V-E-Q-F-P-K-L-E-E-V-I-D-E-L-L-P-K-K-T-E-L-Q-I-I-K-C-S-D-K-I-Q-L-Y-A-V-G-D-E-V-L-F-F-Q-K-F-E-E-L-I-P-T-L-R-F-V-H-K-Y-P-E-A-F-P-T-I-Q-I-D-R-G-A-I-K-F-V-L-S-G-A-N-I-M-C-P-G-L-T-S-S-G-A-A-L-P-E-A-P-G-L-A-Q-D-S-I-V-V-V-N-A-E-N-K-E-N-A-L-A-I-G-K-L-L-M-S-T-E-D-I-K-S-I-N-K-G-H-G-V-E-T-I-H-H-L-G-D-C-L-W-N-F-S-L-V


### FUNCTION Required for the assembly of mitochondrial cytochrome c oxidase ### SEQUENCE -M-S-G-N-P-G-S-A-L-Q-A-L-S-P-T-P-P-E-R-G-S-F-P-L-D-H-E-G-E-C-T-A-Q-M-M-E-Y-L-N-C-M-K-L-V-R-G-E-N-A-P-N-C-R-L-L-A-R-N-Y-L-K-C-R-M-D-H-R-L-M-D-R-D-E-W-A-H-L-G-L-P-D-D-K-R-A-E-A-A-A-S-A-D-S-A-R-P-P-R-Q


### FUNCTION Has a role in mitochondrial fission Has a role in outer membrane fission but not matrix separation ### SEQUENCE -M-S-N-I-N-F-L-P-T-I-E-D-A-Y-G-A-L-S-A-E-Q-L-D-I-L-R-Q-Q-V-L-S-E-G-G-D-I-A-S-I-Q-S-R-F-N-Y-A-W-G-L-V-K-S-H-D-A-E-D-Q-R-L-G-V-K-L-L-T-D-I-Y-K-E-S-P-M-R-R-R-E-S-L-Y-Y-L-A-I-G-C-Y-K-L-G-E-Y-A-M-A-K-R-Y-A-D-A-L-V-A-H-E-P-D-N-A-Q-A-R-T-L-K-A-M-V-E-Q-K-I-Q-T-E-G-L-K-G-A-A-L-V-G-A-G-L-A-A-V-A-A-A-A-G-F-L-L-R-Q-R-R-P


### FUNCTION Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions ### SEQUENCE -M-T-K-K-D-K-K-Q-K-V-K-V-K-T-V-E-T-K-E-G-E-K-I-R-V-F-E-D-L-D-S-F-E-T-Y-L-R-G-E-T-E-D-E-E-F-D-H-V-H-C-Q-V-R-Y-Y-P-P-F-V-L-H-E-S-H-Q-D-P-E-K-I-K-E-S-A-N-S-H-N-K-K-F-V-R-H-L-H-Q-H-V-E-K-H-L-L-K-D-I-K-D-S-L-G-V-P-E-L-K-F-K-D-K-S-K-E-E-N-F-N-H-V-V-W-R-Y-H-A-P-T-A-V-R-D-R-E-F-L-V-H-V-T-V-E-C-H-N-D-T-A-M-V-D-V-D-Y-L-T-E-P-M-Q-P-A-V-Q-S-E-Q-V-A


### FUNCTION Involved in pre-mRNA splicing ### SEQUENCE -M-D-L-N-L-L-K-S-W-N-P-Q-L-Q-K-N-R-K-K-V-Y-E-A-Q-Q-E-L-L-K-S-A-R-K-P-A-D-D-G-T-S-G-G-G-L-D-W-M-Y-E-G-Q-P-A-P-Q-R-K-V-R-K-R-R-T-R-T-R-K-P-K-Q-V-P-K-D-A-Q-G-K-L-Q-E-S-L-Q-T-A-R-S-D-A-P-E-G-T-C-S-P-D-E-T-A-A-A-R-G-G-Q-Q-G-A-P-V-E-V-S-A-K-S-P-A-K-A-V-A-E-A-R-G-G-P-G-S-S-G-V-H-G-E


### FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors ### SEQUENCE -M-S-D-S-N-N-I-S-S-L-Y-P-P-P-P-P-Y-V-K-F-F-T-K-D-N-L-E-R-L-A-E-Y-Q-S-S-H-V-T-T-D-P-E-Q-I-T-C-E-L-D-F-L-I-P-P-P-V-P-S-A-G-H-Y-R-A-F-G-S-V-W-Q-V-K-D-E-L-P-D-L-E-T-V-G-L-R-N-L-Y-D-D-R-G-Q-H-G-N-N-Y-Q-Y-K-I-K-E-L-H-K-L-L-K-S-L-L-L-N-M-L-E-L-V-S-V-L-S-V-N-P-E-R-F-P-D-K-V-E-H-I-R-T-I-L-F-N-I-H-H-L-L-N-E-Y-R-P-H-Q-S-R-E-S-L-I-M-L-L-E-E-Q-L-E-H-K-K-E-E-I-A-N-I-H-A-I-C-D-K-V-Q-A-K-L-A-A-M-C-K-Q-Y-I-A-D-D


### FUNCTION DNA-binding protein that induces severe bending of DNA Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex ### SEQUENCE -M-A-A-A-A-T-T-K-K-R-T-Q-R-K-K-K-D-P-N-A-P-K-R-A-M-S-A-Y-M-F-F-A-N-E-N-R-D-I-V-R-A-E-N-P-G-I-S-F-G-Q-V-G-R-V-L-G-E-K-W-K-A-L-S-D-D-E-K-Q-P-Y-E-A-K-A-E-A-D-K-K-R-Y-E-S-E-K-E-L-Y-N-A-T-K-A-A


### FUNCTION Essential role in pre-mRNA splicing Also essential for entry into mitosis ### SEQUENCE -M-G-S-V-F-L-P-H-L-H-S-G-W-H-V-D-Q-A-I-V-T-E-E-E-R-L-V-V-I-R-F-G-S-D-S-D-R-S-C-M-L-M-D-E-I-L-Y-S-I-A-E-K-V-V-N-F-A-A-I-Y-V-C-D-T-T-E-V-P-D-F-N-E-M-Y-E-L-Q-D-P-M-T-V-M-F-F-Y-K-N-K-H-M-R-C-D-F-G-T-G-N-N-N-K-M-N-F-V-V-D-N-K-Q-E-M-I-D-I-I-E-T-V-F-R-G-A-R-R-N-K-G-L-V-V-S-P-Y-D-Y-N-Y-K-R-I-Q


### FUNCTION Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits Has a physiological role leading to 18S rRNA stability ### SEQUENCE -M-E-N-D-K-G-Q-L-V-E-L-Y-V-P-R-K-C-S-A-T-N-R-I-I-K-A-K-D-H-G-S-V-Q-I-N-I-A-Q-V-D-E-N-G-H-A-V-P-G-E-Y-I-T-Y-A-L-S-G-Y-V-R-A-R-G-E-A-D-D-S-M-N-R-L-A-Q-K-D-G-L-L-K-N-V-W-S-Y-S-R


### FUNCTION Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A The NuA4 complex is also involved in DNA repair ### SEQUENCE -M-E-K-Q-R-K-E-Y-E-E-L-K-Q-K-L-K-Q-A-L-H-E-K-K-V-Q-E-Q-E-W-D-Q-I-Q-Q-E-I-F-D-K-E-T-E-Y-L-S-G-N-A-S-S-K-Y-G-T-I-V-K-G-F-D-G-F-G-K-H-A-S-Q-D-S-H-H-F-Q-D-Q-D-R-I-F-S-L-S-S-A-L-F-V-K-Q-Q-E-G-V-Q-D-E-E


### FUNCTION Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of mitochondrial acyl-carrier-protein ### SEQUENCE -M-L-V-P-H-D-R-M-V-G-N-K-R-R-G-T-M-R-V-L-G-I-G-T-D-L-V-Y-M-P-R-V-V-E-L-L-R-R-M-P-A-G-S-G-A-H-A-R-F-A-G-K-F-M-H-A-R-E-R-A-G-A-L-G-A-K-D-Q-A-R-Y-V-A-G-V-W-A-A-K-E-A-L-Y-K-A-V-A-G-A-D-A-P-P-A-A-T-L-Y-R-A-C-Y-K-E-A-D-A-V-G-R-P-T-L-Q-V-D-A-G-E-L-Q-R-A-G-H-M-R-F-W-E-E-R-L-A-G-T-R-F-L-L-S-V-S-H-D-E-D-Y-L-V-A-F-V-C-H-V-A-D-E-T-F-R-A-P-D-E-R-Q-R-I-T-K-N-S


### FUNCTION Plays a role in the regulation of membrane potential Could mediate a proton leak ### SEQUENCE -M-N-S-T-K-V-V-N-V-I-I-A-I-F-L-P-P-V-A-V-F-L-A-R-G-W-G-V-E-C-I-V-D-L-L-L-T-I-F-F-F-F-P-G-M-L-Y-A-L-Y-I-V-L-T-S


### FUNCTION E2-like enzyme required for the cytoplasm to vacuole transport ### SEQUENCE -M-L-S-A-E-D-F-S-D-Q-V-L-R-L-L-P-L-L-R-R-W-R-R-C-E-H-A-L-W-D-P-R-A-R-R-L-Q-L-S-V-A-T-A-R-N-S-A-R-F-D-V-R-V-D-L-H-P-L-Y-A-V-P-Q-L-L-L-R-Y-W-E-P-D-P-A-V-S-E-Y-E-V-W-K-L-H-F-V-D-P-Y-Q-L-P-L-W-Q-P-G-R-F-S-I-A-L-D-Q-V-P-A-T-S-G-S-A-Y-E-T-W-Y-V-V-N-S-C-D-T-D-A-N-V-G-P-E-T-D-N-Y-M-L-R-W-F-S-L-Y-G-Q-L-L-D-E-N-L-G-F-T-L-A-A-A-L-V-A-P-C-T-D-Q-K-K-A


### FUNCTION Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes ### SEQUENCE -M-P-H-I-Q-F-L-P-P-E-P-V-V-L-V-S-R-V-A-D-D-P-D-P-A-G-P-G-L-H-V-A-K-V-A-V-G-D-C-T-I-V-D-A-R-T-P-C-A-P-L-Q-G-R-F-A-V-W-T-V-A-L-Q-L-H-S-P-D-T-P-R-S-L-T-L-R-K-R-Y-S-D-F-V-R-F-R-E-R-L-L-L-C-L-P-P-P-L-R-R-A-V-P-P-L-P-P-P-V-P-W-Y-D-A-W-R-Y-S-D-V-N-L-D-R-A-W-L-A-A-R-R-A-G-L-E-R-F-L-Q-Q-V-L-L-N-R-A-L-V-A-A-A-P-V-V-V-R-G-F-L-E-P-P-A-A-H-R-W-V-P-V-R-A


### FUNCTION Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin ### SEQUENCE -M-K-S-S-A-Q-L-C-M-E-A-R-N-Y-N-F-N-A-A-A-P-L-R-L-Y-L-A-T-C-V-R-L-V-E-E-A-Q-A-A-A-Q-A-D-D-V-A-R-A-Y-M-L-Y-V-R-Y-L-D-L-C-M-H-Q-L-S-G-H-R-E-V-Q-Q-P-V-T-D-A-E-R-L-S-R-D-E-Y-E-Q-L-L-R-L-E-V-P-A-V-L-R-L-T-E-E-L-K-S-A-V-D-L-R-H-E-R-G-R-A-S-L-A-R-S-V-V-P-E-A-G-R-G-E-H-S-R-Q-E-V-Q-L-P-P-S-F-D-E-E-R-F-N-R-T-V-Q-W-F-L-A-A-G-R-S-M-S-L-P-V-S-A-E-E-P-A-V-R-E-V-F-S-Y-P-E-L-P-K-L-S-M-A-A-E-S-W-A-P-S


### FUNCTION Involved in the processing of the 20S pre-rRNA ### SEQUENCE -M-V-G-V-G-K-K-F-T-K-E-S-K-V-R-E-I-Q-K-N-L-H-K-R-A-K-L-K-R-Q-Y-L-K-T-L-E-Q-E-G-Y-E-V-P-E-E-Q-K-R-Q-K-P-S-F-E-Q-R-K-G-E-K-K-Q-K-V-D-E-K-K-E-H-A-R-R-R-K-R-E-Q-K-E-E-M-E-A-K-R-Q-R-E-L-D-E-L-E-R-A-K-V-R-Q-V-E-R-E-R-R-N-K-R-I-Q-Q-K-T-R-S-G-Q-P-K-M-G-P-R-I-N-D-L-L-D-K-I-Q-K-D-T-T-Y-T-S


### FUNCTION Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 ### SEQUENCE -M-L-T-T-T-I-P-Q-F-P-D-T-K-L-Y-I-S-L-F-R-N-V-S-N-A-P-E-I-V-D-S-L-A-E-L-P-Y-S-I-I-D-A-R-T-L-L-S-R-E-Q-L-L-S-A-V-Y-R-A-M-L-E-K-H-C-N-K-L-R-T-R-N-L-H-T-E-V-L-L-C-L-S-P-T-S-N-V-M-S-Q-I-G-D-A-M-K-R-F-G-I-K-K-D-S-T-S-V-V-L-V-K-A-V-T-G-D-E-T-F-D-P-K-G-F-S-E-V-I-R-G-E-E-L-E-F-S-D-T-A-L-R-E-S-A-D-I-D-T-I-R-E-N-Y-K-L-K-C-F-E-C-E-R-L-E-E-L-S-A-A-L-V-H-A-I-Q-L-R-G-L


### FUNCTION Involved in the assembly of the cytochrome c oxidase complex ### SEQUENCE -M-A-W-W-P-F-S-R-N-N-K-P-G-V-P-E-Q-D-Q-V-A-A-A-P-V-Q-Q-R-P-A-E-P-L-P-T-N-Y-T-P-G-Q-R-L-L-L-E-D-T-R-P-R-F-D-T-Q-S-S-A-S-Q-Q-A-V-Q-R-E-R-A-T-L-A-D-A-W-K-T-V-R-W-E-D-F-S-L-E-R-M-A-G-I-P-C-F-R-D-A-G-M-A-G-F-S-A-M-V-V-A-G-S-V-T-F-L-F-H-K-N-P-V-R-A-A-N-W-G-V-G-G-L-L-L-G-S-I-V-G-W-E-Q-C-R-M-Q-R-R-R-S-F-Q-V-A-E-M-A-R-Q-T-V-A-A-K-E-A-P-M-L-R-K-P-D-N-A-Q-K-A-G-A-V-S-Q-A-S-E-L-P-P-K-K-P-W-Y-R-F-W


### FUNCTION Probable component of the GPI-GlcNAc transferase  complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins ### SEQUENCE -M-N-D-K-V-A-A-T-L-V-L-V-V-T-Y-S-I-V-G-A-S-L-W-C-L-T-Y-A-W-H-D-E-T-K-L-Y-Y-W-C-I-V-Q-L-L-P-V-M-L-W-V-W-C-V-I-S-W-C-G-A-Q-L-F-G-Y-A-K-R-G-K-A-D


### FUNCTION Component of the INA complex -domain ### SEQUENCE -M-I-R-Y-A-L-L-R-S-G-R-R-T-L-Q-T-R-P-S-P-Q-T-L-E-E-L-A-R-L-K-S-L-E-D-V-D-S-S-V-I-R-K-L-I-N-Q-R-T-E-E-V-N-A-Q-N-E-A-Q-M-L-K-K-L-S-A-E-G-R-D-L-Q-N-V-P-G-S-R-Y-A-R-P-L-W-L-L-L-I-G-C-A-S-V-Y-L-V-R-D-W-L-R-M-K-A-E-Y-D-A-R-E-T-T-L-E-T-R-V-E-G-L-E-A-E-L-K-Y-L-L-E-P-K-P-G-V-L-E-V-E-V-V-Q-T-E-V-A-S-S-A-P-W-Y-K-R-W-L-W-S-G-S-R


### FUNCTION Required for the assembly of cytochrome c oxidase ### SEQUENCE -M-P-V-D-T-A-A-P-Q-S-T-A-N-P-D-P-S-V-Q-T-D-R-A-A-V-N-F-T-P-S-T-D-A-S-S-F-Q-F-Y-P-D-N-P-E-S-P-L-A-R-Y-R-F-A-A-K-G-P-S-Q-Y-F-D-P-C-Q-E-S-A-N-M-S-M-K-C-L-E-R-N-N-Y-D-R-D-L-C-R-E-Y-F-D-A-Y-R-E-C-K-K-Q-W-L-S-A-R-R-K-D-N-S-Q-W-T


### FUNCTION Component of the biogenesis of lysosome-related organelles complex-1  involved in endosomal cargo sorting ### SEQUENCE -M-N-E-K-Q-L-R-Q-Q-L-D-R-C-L-D-H-V-Q-E-H-V-D-M-L-S-A-R-A-I-S-K-L-S-G-D-A-V-A-N-H-E-W-L-S-E-L-S-G-R-Y-P-T-R-S-A-E-E-L-Q-Q-F-R-E-L-K-D-G-Y-V-K-K-L-D-T-L-E-T-E-V-K-Y-L-E-D-L-G-Q-E-L-A-E-F-Q-N-E-L-S-V-K-L-Q-R-I-R-R-N-S-Y-V-Q-E-N


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-S-G-I-S-P-T-E-L-Q-N-L-D-E-P-S-K-K-E-I-M-G-F-L-E-T-E-N-S-K-Q-K-V-Q-M-S-I-H-Q-F-T-N-L-C-F-K-N-C-I-H-S-V-Q-S-A-D-L-S-A-Q-E-N-Q-C-L-K-D-C-V-N-R-F-L-D-T-N-I-R-I-V-K-G-L-Q-S-I-Q


### FUNCTION Required for the assembly of the V0 complex of the vacuolar ATPase  in the endoplasmic reticulum ### SEQUENCE -M-A-V-D-V-P-T-S-V-I-V-K-L-M-F-F-T-L-A-M-V-S-F-P-V-L-T-F-F-V-S-Q-Q-Y-T-S-N-T-L-V-N-G-G-L-A-A-L-A-A-N-V-V-L-F-A-Y-V-I-M-A-F-S-E-D-V-P-Q-S-D-G-K-E-S-K-K-Q-Q


### FUNCTION Allows the formation of correctly charged Gln-tRNA Required for proper protein synthesis within the mitochondrion ### SEQUENCE -M-P-L-A-R-L-V-E-G-E-K-H-D-E-C-T-Y-V-A-A-S-S-L-L-I-G-R-H-K-M-L-R-S-L-I-Y-A-S-R-R-W-S-S-S-V-G-A-R-F-S-S-R-E-E-L-Q-A-Y-L-A-R-P-A-W-Q-P-E-D-Y-L-P-S-A-E-D-I-A-R-Q-Q-L-S-E-E-E-T-R-K-L-L-K-L-S-G-L-P-E-A-D-I-Q-E-V-R-R-R-L-A-T-Q-L-S-F-V-S-Q-L-Q-S-V-E-V-D-D-C-A-D-P-Q-Y-A-K-A-M-Q-R-H-P-A-A-I-G-Y-E-E-L-V-R-R-A-E-L-D-A-K-D-T-S-L-G-E-K-S-G-S-W-D-S-T-A-T-A-T-L-K-K-D-G-Y-F-V-L-R-E-G-L-L-Q-K-R


### FUNCTION Subunit of the V0 complex of vacuolar ### SEQUENCE -M-S-F-Y-T-V-V-A-T-F-L-S-V-V-L-A-S-A-V-F-W-V-L-A-P-K-E-N-Q-T-V-W-R-S-T-I-I-L-S-M-S-M-M-F-L-M-W-A-V-T-Y-L-S-Q-L-H-P-L-V-V-P-R-R-S-D-L-R-P-E-F-A-E


### FUNCTION Involved in telomere length regulation and promotes fully efficient non-homologous end-joining  by a mechanism activated in postdiauxic/stationary phase ### SEQUENCE -M-D-P-L-D-V-E-D-E-V-D-E-S-D-T-T-S-L-Q-A-Q-L-R-Q-N-A-I-R-K-Q-E-Q-F-Q-Q-E-I-Q-E-R-N-S-M-V-N-R-M-S-A-E-A-L-Q-Y-F-N-Q-L-H-K-A-E-C-S-K-K-E-E-L-Q-T-Y-I-D-E-N-L-K-V-F-E-K-K-Q-K-R-A-Q-A-P-T-K-N-N-E-R-S-S-S-T-H-A-A-L-E-E-H-K-A-A-S-V-T-K-K-K-L-G-I-V-K-K-G-A-P-R-K-T-K-I-R-L-P-V-R-K-S-P-N


### FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors ### SEQUENCE -M-T-D-R-L-T-Q-L-Q-Q-C-L-D-Q-I-V-E-Q-F-G-S-A-I-T-Y-V-D-R-N-H-D-F-E-P-H-N-E-L-E-D-K-L-S-D-P-Q-A-T-I-A-A-A-E-D-F-D-R-N-I-D-E-L-T-T-D-M-I-L-K-T-R-Q-I-I-K-L-I-D-S-L-P-G-V-D-V-S-A-E-E-Q-L-S-R-I-D-S-L-Q-K-K-L-I-Q-V-E-G-E-K-I-E-A-I-K-R-K-E-S-L-T-K-D-I-E-E-L-I-N-E-F-T-E-G-I-A-N-S-R-R-L-N-K-A


### FUNCTION Involved in telomere length regulation ### SEQUENCE -M-L-Q-T-R-L-F-H-A-C-A-A-L-A-R-A-A-S-R-P-V-P-K-P-T-S-E-I-P-D-V-S-T-F-L-A-K-I-G-R-Q-C-S-E-H-A-E-L-Y-E-N-K-W-E-N-L-F-M-W-D-G-P-K-L-K-E-K-G-V-P-V-Q-Q-R-R-Y-I-L-Q-Q-V-E-R-L-R-Q-G-G-P-V-R-E-I-R-E-G-K-K-S-F-F-G-G-E-R-K-R-K-E-K-V-A-K-W-R-A-E-Q-R-H-A-A


### FUNCTION Plays a role in autophagy Functions at the preautophagosomal structure ### SEQUENCE -M-N-S-K-N-T-I-V-Y-V-K-V-P-G-R-Q-R-E-G-F-V-D-P-P-P-F-E-W-N-Q-H-Q-D-R-K-L-W-A-H-I-S-T-I-E-D-K-D-D-I-D-W-Q-L-L-S-N-Q-T-N-A-P-E-F-F-I-R-K-R-V-Y-Q-L-F-R-V-H-L-K-S-I-E-Q-E-I-Y-S-H-T-S-A-D-R-A-P-N-R-S-S-Q-A-G-D-E-P-A-A-S-V-G-V-L-N-G-Y-G-Q-N-I-N-D-I-H-D-L-S-S-L-Q-T-P-P-T-C-R-G-K-A-N-K-D-E-D-G-G-N-S-S-G-I-S-E-L-S-S-L-S-V-S-K-S-A-L-E-E-A-L-M-D-R-L-Q-L


### FUNCTION Essential for the assembly of ubiquinol-cytochrome c reductase It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b ### SEQUENCE -M-E-R-P-V-W-F-R-W-L-R-V-Y-A-I-G-F-G-I-I-G-A-G-V-L-L-F-K-Y-T-T-P-T-D-E-E-L-I-A-A-L-S-P-E-L-R-Q-Q-Y-E-R-E-R-K-L-R-Q-A-E-Q-Q-E-L-M-R-I-V-K-Q-T-A-A-S-E-T-P-V-W-N-T-G-P-I-K-S-P-W-E-R-K-G-V-S-A-E-S-R-E-Q-F-Q-Q-V-K-A-E-Q-V-Q-R-E-E-L-Q-R-I-R-E-E-L-E-T-I-R-Q-Q-S-A-N-K-T-Q-E-I-A-S-K-K-S-W-W-P-W


### FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery ### SEQUENCE -M-A-L-S-S-I-F-G-G-G-S-P-S-Q-Q-S-N-L-P-T-S-S-A-S-S-S-V-K-D-Q-L-K-G-Q-I-A-Q-E-L-A-V-A-N-A-T-E-L-V-N-K-V-T-E-N-C-F-E-K-C-L-M-A-P-Y-T-S-K-Q-D-T-C-V-D-Q-C-L-A-K-Y-M-R-S-W-N-A-I-S-Q-A-Y-V-A-R-I-Q-Q-A-S-A-N-G-D-I


### FUNCTION Required for the assembly of the mitochondrial respiratory chain complex IV , also known as cytochrome c oxidase May participate in merging the COX1 and COX2 assembly lines ### SEQUENCE -M-S-L-G-S-R-T-F-R-S-K-R-Q-M-A-A-F-E-K-S-L-Q-G-R-Y-L-K-L-L-R-R-N-P-F-L-F-Y-G-V-P-F-C-T-L-M-A-V-G-S-Y-C-L-S-D-F-T-A-V-K-Y-E-R-E-D-K-K-V-R-S-V-Q-E-D-E-L-V-K-L-R-A-N-R-R-T-V-D-L-K-E-E-F-Y-R-L-Q-G-L-A-D-Q-D-W-E-P-V-R-V-P-R-L-P-G-E-S-E-N-V-W-D-V-E


### FUNCTION Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis ### SEQUENCE -M-S-I-V-K-S-K-I-R-T-I-P-D-Y-P-K-P-G-I-L-F-R-D-I-T-S-L-L-L-D-P-E-G-L-A-L-T-I-G-T-F-V-N-R-Y-Q-G-K-G-I-T-K-V-A-G-I-E-A-R-G-F-L-T-G-A-P-L-A-F-Q-L-G-V-G-F-I-P-I-R-K-K-G-K-L-P-S-E-T-V-S-E-E-Y-D-L-E-Y-G-K-D-V-I-E-V-H-K-D-S-I-Q-P-G-D-K-I-L-L-M-D-D-L-I-A-T-G-G-T-M-I-A-A-V-K-L-L-K-K-L-G-A-E-I-Y-E-A-G-V-I-I-D-L-P-D-L-G-G-R-K-K-L-Q-E-E-L-K-V-P-V-F-S-I-C-E-F-E-G-H


### FUNCTION Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors , playing an important role in chemotaxis ### SEQUENCE -M-L-T-K-G-S-K-V-V-N-V-G-I-A-D-M-Q-G-A-Q-S-P-E-I-L-R-T-T-L-G-S-C-I-G-V-V-F-Y-A-P-D-K-K-I-G-A-M-A-H-F-M-L-S-K-D-P-S-G-K-D-S-Q-K-N-P-F-K-Y-A-E-T-A-I-P-L-L-I-K-K-M-N-E-M-G-C-N-P-G-E-Y-S-V-R-L-F-G-G-A-S-M-F-K-G-V-Q-S-S-F-L-Q-N-I-G-E-Q-N-I-L-T-A-R-A-I-L-E-Q-S-K-I-P-L-I-L-E-D-V-G-G-N-D-G-R-T-I-S-L-Y-L-D-D-G-R-V-L-L-K-K-G-G-F-E-K-Y-L-Y-K-V-R


### FUNCTION Carrier of the growing fatty acid chain in fatty acid biosynthesis ### SEQUENCE -M-A-D-F-E-K-V-K-S-I-I-V-E-Q-L-G-V-D-E-S-E-V-T-P-E-A-H-F-I-D-D-L-G-A-D-S-L-D-T-V-E-L-V-M-A-L-E-E-E-F-G-I-E-I-S-D-E-D-A-E-K-I-Q-T-V-G-D-V-T-K-F-I-D-N-L-K-S


### FUNCTION Mitochondrial membrane ATP synthase ### SEQUENCE -M-P-Q-M-I-P-F-F-F-M-N-Q-L-T-Y-G-F-T-F-I-L-T-I-L-F-L-T-S-Y-V-F-L-P-M-I-L-R-L-Y-I-S-R-L-Y-I-S-K-L


### FUNCTION Probable thiol-disulfide oxidoreductase that may be involved in the redox regulation of a number of cytosolic enzymes ### SEQUENCE -M-G-C-C-G-S-S-T-V-D-A-E-E-H-L-D-Y-S-G-G-N-V-T-L-V-T-D-Q-K-N-W-D-N-T-M-E-E-V-A-E-H-G-K-T-V-V-L-K-F-S-A-I-W-C-T-P-C-R-N-A-A-P-L-F-A-E-L-S-L-K-Y-P-D-I-V-F-V-S-V-D-V-D-E-M-P-E-L-V-T-Q-Y-D-V-R-A-T-P-T-F-I-F-M-K-N-N-E-E-I-D-K-L-V-G-G-N-H-E-D-L-Q-E-K-F-E-Q-L-N-R-P-K-L-Y-D-D-V


### FUNCTION May serve as docking site to facilitate the association of other proteins to the plasma membrane ### SEQUENCE -M-S-G-G-V-Q-E-Q-F-E-I-K-F-R-L-P-D-G-T-D-I-G-P-K-R-Y-P-A-A-S-T-V-A-T-L-K-E-S-I-V-A-Q-W-P-K-D-K-E-K-G-P-R-T-V-N-D-L-K-L-I-N-A-G-K-I-L-E-N-N-K-T-L-S-E-C-K-S-P-I-C-D-F-S-G-L-T-T-M-H-V-V-V-R-A-P-T-S-D-K-Q-S-N-K-I-V-A-K-K-P-K-D-F-R-C-G-C-S-I-M


### FUNCTION Tubulin-folding protein ### SEQUENCE -M-V-L-D-T-K-R-S-L-K-I-K-I-D-A-L-K-R-L-E-K-D-Y-M-L-Y-K-K-E-E-Q-L-Q-I-E-N-V-E-R-F-K-A-D-E-T-K-D-I-Y-D-V-K-K-Q-I-E-I-L-D-E-N-K-T-M-I-I-D-S-V-S-R-V-T-A-F-L-V-Q-F-S-E-F-L-E-E-H-K-N-E-D-D-G-S-E-I-W-K-D-S-Y-D-I-I-D-Q-I-S-T-K-F-L-G-E


### FUNCTION Mitochondrial membrane ATP synthase ### SEQUENCE -M-A-G-Q-Y-W-R-A-A-G-I-T-Y-L-Q-Y-A-N-I-C-G-T-H-V-R-N-C-L-K-E-P-F-R-A-A-A-K-N-R-E-G-F-I-S-N-T-V-M-Y-Q-N-G-K-E-S-S-T-I-I-L-N-S-E-L-L-Q-K-E-L-L-V-K-K-N


### FUNCTION Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes May directly activate some type-A response regulators in response to cytokinins ### SEQUENCE -M-A-R-K-M-I-R-V-L-L-V-E-D-E-E-I-N-R-V-V-A-R-A-A-L-K-A-A-G-G-G-D-V-V-D-E-A-E-N-G-E-V-A-V-Q-R-V-R-D-A-A-A-P-Y-D-L-V-L-M-D-K-Q-M-P-V-M-D-G-H-E-A-T-R-R-I-R-G-M-G-V-T-T-P-I-V-A-V-S-S-D-G-L-P-A-D-V-D-A-F-I-T-A-G-A-D-D-F-T-S-K-P-L-S-K-E-K-L-G-V-I-L-A-K-F-R-L-A


### FUNCTION Beta-2 bungarotoxin is a presynaptic neurotoxin of the venom The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic ### SEQUENCE -S-S-G-G-L-L-L-L-L-G-L-L-T-L-C-A-E-L-I-P-V-S-S-R-Q-R-H-R-D-C-D-K-P-P-D-K-G-N-C-G-S-V-R-R-A-F-Y-Y-D-T-R-L-K-T-C-K-A-F-P-Y-R-G-C-N-G-N-G-N-H-F-K-T-E-T-L-C-R-C-E-C-L-V-Y-P


### FUNCTION Beta-bungarotoxin is a presynaptic neurotoxin of the venom The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic ### SEQUENCE -M-S-S-G-G-L-L-L-L-L-G-L-L-T-L-W-A-E-L-T-P-V-S-S-R-K-R-H-P-D-C-D-K-P-P-D-T-R-I-C-Q-T-V-V-R-A-F-Y-Y-K-P-S-E-K-R-C-V-Q-F-R-Y-G-G-C-K-G-N-G-N-H-F-K-S-D-H-L-C-R-C-E-C-L-E-Y-R


### FUNCTION Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides ### SEQUENCE -M-T-D-V-K-K-N-E-N-M-T-F-E-E-A-M-K-K-L-E-E-I-V-E-K-L-E-E-G-N-V-P-L-E-E-A-I-A-F-F-Q-E-G-M-K-L-S-K-L-C-H-D-K-L-Q-H-V-E-K-Q-L-E-Y-M-L-R-E-D-G-E-L-V-P-F-S-P-E-E-E


### FUNCTION Involved in urease metallocenter assembly Binds nickel Probably functions as a nickel donor during metallocenter assembly ### SEQUENCE -M-I-I-E-T-I-I-G-N-I-Q-T-L-P-S-L-P-P-H-I-E-R-V-Y-M-A-S-D-D-L-V-K-R-I-Q-R-V-V-T-D-H-G-R-E-L-G-I-R-L-K-E-A-K-E-L-A-D-G-D-V-L-W-M-D-D-H-N-A-I-V-V-S-V-L-P-E-D-L-L-V-I-K-P-V-S-L-K-Q-M-G-E-I-A-H-Q-I-G-N-R-H-L-P-A-Q-F-E-E-G-E-M-L-V-Q-Y-D-Y-L-V-E-E-L-L-Q-Q-L-A-I-P-Y-K-R-E-K-R-K-V-K-Q-A-F-R-H-I-G-H-R-H-D


### FUNCTION Involved in calcium binding and microtubule stabilization ### SEQUENCE -M-K-I-Y-K-D-I-I-T-G-D-E-M-F-S-D-T-Y-K-M-K-L-V-D-E-V-I-Y-E-V-T-G-R-L-V-T-R-A-Q-G-D-I-Q-I-E-G-F-N-P-S-A-E-E-A-D-E-G-T-D-S-A-V-E-S-G-V-D-I-V-L-N-H-R-L-V-E-T-Y-A-F-G-D-K-K-S-Y-T-L-Y-L-K-D-Y-M-K-K-L-V-A-K-L-E-E-K-A-P-D-Q-V-E-V-F-K-T-N-M-N-K-V-M-K-D-I-L-G-R-F-K-E-L-Q-F-F-T-G-E-S-M-D-C-D-G-M-V-A-M-M-E-Y-R-D-F-D-G-T-Q-I-P-I-M-M-F-F-K-H-G-L-E-E-E-K-F


### FUNCTION Inhibits voltage-gated sodium channels by binding to site 3 Insecticidal neurotoxin ### SEQUENCE -T-S-Q-G-T-T-P-D-K-V-Q-L-E-V-N-C-I-S-N-L-P-N-N-E-V-E-E-T-D-L-L-R-E-L-E-M-I-E-E-N-L-F-G-K-E-L-S-F-V-P-E-E-N-R-N-S-R-H-K-R-C-M-G-Y-D-I-E-C-N-E-R-L-H-C-C-A-D-L-E-C-V-K-T-S-G-R-W-W-Y-K-K-T-Y-C-R-R-K-S-G


### FUNCTION RuBisCO catalyzes two reactions the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process Both reactions occur simultaneously and in competition at the same active site Although the small subunit is not catalytic it is essential for maximal activity ### SEQUENCE -M-R-V-T-Q-G-T-F-S-F-L-P-D-L-T-D-E-Q-I-N-K-Q-L-A-Y-I-V-S-K-G-F-S-A-N-V-E-Y-T-D-D-P-H-P-R-N-S-Y-W-E-L-W-G-L-P-L-F-D-V-K-D-A-S-A-V-M-Y-E-I-S-S-C-R-K-A-K-P-N-Y-Y-I-K-V-N-A-F-D-N-T-R-G-I-E-S-C-V-L-S-F-I-V-N-R-P-I-N-E-P-G-F-L-L-Q-R-Q-D-F-E-G-R-T-M-K-Y-S-L-H-S-Y-A-T-E-K-P-E-G-A-R-Y


### FUNCTION RuBisCO catalyzes two reactions the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process Both reactions occur simultaneously and in competition at the same active site Although the small subunit is not catalytic it is essential for maximal activity ### SEQUENCE -M-R-L-T-Q-G-A-F-S-F-L-P-D-L-T-D-E-Q-I-N-K-Q-L-A-Y-I-V-S-K-G-L-S-A-N-V-E-Y-T-D-D-P-H-P-R-N-S-Y-W-E-L-W-G-L-P-L-F-D-V-K-D-A-S-A-V-M-Y-E-I-S-S-C-R-K-A-K-P-N-Y-Y-V-K-V-N-A-F-D-N-T-R-G-I-E-S-C-V-M-S-F-I-V-N-R-P-A-N-E-P-G-F-L-L-Q-R-Q-D-F-E-G-R-T-M-K-Y-S-L-H-S-Y-A-T-E-K-P-E-G-A-R-Y


### FUNCTION RuBisCO catalyzes two reactions the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process Both reactions occur simultaneously and in competition at the same active site Although the small subunit is not catalytic it is essential for maximal activity ### SEQUENCE -M-R-L-T-Q-G-T-F-S-F-L-P-D-L-T-D-E-Q-I-S-K-Q-L-T-Y-I-V-S-K-G-L-S-A-N-V-E-Y-T-D-D-P-H-P-R-N-S-Y-W-E-L-W-G-L-P-L-F-D-V-K-D-A-S-A-V-M-Y-E-I-S-S-C-R-K-A-K-P-N-Y-Y-I-K-V-N-A-F-D-N-T-R-G-I-E-S-C-V-M-S-F-I-V-N-R-P-I-N-E-P-G-F-L-L-Q-R-Q-D-F-E-G-R-T-M-K-Y-S-L-H-S-Y-A-T-E-K-P-E-G-A-R-Y


### FUNCTION RuBisCO catalyzes two reactions the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process Both reactions occur simultaneously and in competition at the same active site Although the small subunit is not catalytic it is essential for maximal activity ### SEQUENCE -M-R-L-T-Q-G-T-F-S-F-L-P-D-L-T-D-E-Q-I-N-K-Q-L-T-Y-I-V-S-K-G-L-S-A-N-V-E-Y-T-D-D-P-H-P-R-N-S-Y-W-E-L-W-G-L-P-L-F-D-V-K-D-A-S-A-V-M-Y-E-I-S-S-C-R-K-A-K-P-N-Y-Y-V-K-V-N-A-F-D-N-T-R-G-I-E-S-C-V-M-S-F-I-V-N-R-P-A-N-E-P-G-F-L-L-Q-R-Q-D-F-E-G-R-T-M-K-Y-S-L-H-S-Y-A-T-E-K-P-E-G-A-R-Y


### FUNCTION RuBisCO catalyzes two reactions the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process Both reactions occur simultaneously and in competition at the same active site Although the small subunit is not catalytic it is essential for maximal activity ### SEQUENCE -M-R-L-T-Q-G-T-F-S-F-L-P-D-L-T-D-E-Q-I-N-K-Q-L-A-Y-I-V-S-K-G-L-S-A-N-V-E-Y-T-D-D-P-H-P-R-N-S-Y-W-E-L-W-G-L-P-L-F-D-V-K-D-A-S-A-V-M-Y-E-I-S-S-C-R-K-A-K-P-N-Y-Y-V-K-V-N-A-F-D-N-T-R-G-I-E-S-C-V-M-S-F-I-V-N-R-P-A-N-E-P-G-F-L-L-Q-R-Q-D-F-E-G-R-T-M-K-Y-S-L-H-S-Y-A-T-E-K-P-E-G-A-R-Y


### FUNCTION May have antimicrobial activity ### SEQUENCE -M-M-F-T-Y-V-V-A-V-A-S-V-V-A-L-T-S-A-Y-P-T-G-A-P-P-S-A-C-F-D-M-I-P-G-H-A-A-D-V-Q-T-V-P-A-P-Y-T-I-T-T-A-V-S-S-V-K-A-G-H-S-I-D-V-V-I-S-G-K-T-P-E-D-K-M-A-G-I-L-L-E-A-R-Q-G-D-K-I-V-G-T-W-T-V-S-P-D-D-T-F-S-Q-P-L-N-C-G-E-P-N-N-A-V-T-H-K-M-H-A-K-E-L-D-R-Q-T-V-S-Y-P-W-T-A-P-K-D-L-E-G-D-V-V-F-K-V-T-I-V-K-S-Y-A-V-F-W-V-G-I-E-S-A-P-V-K-V-L-S-H


### FUNCTION Escorts unspliced or incompletely spliced viral pre-mRNAs ### SEQUENCE -M-T-T-R-E-K-D-L-Q-K-G-L-R-L-L-H-L-L-H-Q-T-N-P-Y-P-Q-T-P-G-T-A-S-Q-R-R-N-R-R-R-R-W-K-R-R-G-L-Q-I-L-A-L-A-D-R-I-R-S-L-S-D-S-P-T-E-E-P-L-D-L-A-V-Q-R-L-Q-E-L-T-V-E-D-L-P-N-P-P-T-S-T-P-T-A-Q-A-F-T-C-I-P-P-V-W-D-Q-L-V-P-R-S-N-P-S-S-N-E-G-C-E-R-D-S-C-E-H-R-K-S-P-M-E-S-S-Q-K-D-S-G-S-N-H-R-D-P-Q-E-D-Q-T-R-T


### FUNCTION Plays a role in nuclear translocation of the viral pre-integration complex ### SEQUENCE -M-D-P-R-E-R-V-P-P-G-N-S-D-E-E-T-I-G-E-A-F-D-W-L-E-R-T-I-T-E-L-N-R-V-A-V-N-H-L-P-R-E-L-I-F-Q-V-W-Q-R-C-W-A-Y-W-R-E-E-Q-G-M-S-S-S-Y-T-K-Y-R-Y-L-L-L-M-Q-K-A-M-F-V-H-Y-T-K-G-C-R-C-L-Q-E-G-H-G-P-G-G-W-R-S-G-P-P-P-P-P-P-P-G-L-A


### FUNCTION Stimulates gene expression driven by the HIV-2 LTR Prevents infected cells from undergoing mitosis and proliferating, by inducing arrest or delay in the G2 phase of the cell cycle Cell cycle arrest creates a favorable environment for maximizing viral expression and production ### SEQUENCE -M-A-E-A-A-P-E-T-P-P-E-N-E-S-P-Q-R-E-P-W-E-E-W-V-E-D-V-M-E-E-I-K-Q-E-A-L-R-H-F-D-P-R-L-L-T-A-L-G-N-F-I-Y-S-R-H-G-D-T-L-A-G-A-G-E-L-I-K-I-L-Q-R-A-L-F-L-H-F-R-A-G-C-Q-H-S-R-I-G-Q-P-G-G-G-N-P-L-S-A-I-P-P-S


### FUNCTION Effector component of the propane 2-monooxygenase multicomponent enzyme system which is involved in the degradation of propane via the O2-dependent hydroxylation of propane ### SEQUENCE -M-Q-F-G-A-D-T-E-F-S-N-M-C-G-V-T-L-M-N-T-P-I-G-R-V-V-A-D-V-M-G-A-K-D-G-V-E-L-T-E-Y-P-S-M-I-R-V-D-G-V-N-R-L-D-F-D-Y-D-E-L-T-D-A-L-G-Q-D-F-D-G-S-I-F-E-E-I-S-S-T-H-Y-G-R-M-V-H-L-D-D-K-T-I-L-F-A-S-P-E-D-A-A-E-F-I-G-F-D-L-T-A-S


### FUNCTION Involved in peptide bond synthesis Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase ### SEQUENCE -M-I-S-V-T-D-L-R-P-G-T-K-V-K-M-D-G-G-L-W-E-C-V-E-Y-Q-H-Q-K-L-G-R-G-G-A-K-V-V-A-K-F-K-N-L-E-T-G-A-T-V-E-R-T-F-N-S-G-E-K-L-E-D-I-Y-V-E-T-R-E-L-Q-Y-L-Y-P-E-G-E-E-M-V-F-M-D-L-E-T-Y-E-Q-F-A-V-P-R-S-R-V-V-G-A-E-F-F-K-E-G-M-T-A-L-G-D-M-Y-E-G-Q-P-I-K-V-T-P-P-T-V-V-E-L-K-V-V-D-T-P-P-G-V-R-G-D-T-V-S-G-G-S-K-P-A-T-L-E-T-G-A-V-V-Q-V-P-L-F-V-E-P-G-E-V-I-K-V-D-T-R-T-G-E-Y-V-G-R-A


### FUNCTION Component of the large ribosomal subunit The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell ### SEQUENCE -M-A-A-L-R-P-L-V-K-P-K-I-V-K-K-R-T-K-K-F-I-R-H-Q-S-D-R-Y-V-K-I-K-R-N-W-R-K-P-R-G-I-D-N-R-V-R-R-R-F-K-G-Q-I-L-M-P-N-I-G-Y-G-S-N-K-K-T-K-H-M-L-P-S-G-F-R-K-F-L-V-H-N-V-K-E-L-E-V-L-L-M-C-N-K-S-Y-C-A-E-I-A-H-N-V-S-S-K-N-R-K-A-I-V-E-R-A-A-Q-L-A-I-R-V-T-N-P-N-A-R-L-R-S-E-E-N-E


### FUNCTION This is an intracellular thiol proteinase inhibitor Tightly binding reversible inhibitor of cathepsins L, H and B ### SEQUENCE -M-M-C-G-A-P-S-A-T-Q-P-A-T-A-E-T-Q-H-I-A-D-Q-V-R-S-Q-L-E-E-K-E-N-K-K-F-P-V-F-K-A-V-S-F-K-S-Q-V-V-A-G-T-N-Y-F-I-K-V-H-V-G-D-E-D-F-V-H-L-R-V-F-Q-S-L-P-H-E-N-K-P-L-T-L-S-N-Y-Q-T-N-K-A-K-H-D-E-L-T-Y-F


### FUNCTION May be involved in the development and regeneration of the musculoskeletal system ### SEQUENCE -M-S-Q-P-D-P-V-K-K-K-R-P-P-V-K-E-E-D-L-K-G-A-R-G-N-L-S-K-N-Q-E-I-K-S-K-T-Y-Q-V-M-K-Q-C-E-Q-M-G-S-A-A-P-S-I-F-S-R-A-R-T-G-S-E-T-V-F-E-K-S-K-D-E-P-P-K-S-V-F-G


### FUNCTION Mediates the nuclear export of encapsidated genomic RNAs  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain This domain is believed to allow recognition of RNPs bound to the protein M1 Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane May down-regulate viral RNA synthesis when overproduced ### SEQUENCE -M-D-P-N-T-V-S-S-F-Q-D-I-L-L-R-M-S-K-M-Q-L-E-S-S-S-E-D-L-N-G-M-I-T-Q-F-E-S-L-K-L-Y-R-D-S-L-G-E-A-V-M-R-M-G-D-L-H-S-L-Q-N-R-N-E-K-W-R-E-Q-L-G-Q-K-F-E-E-I-R-W-L-I-E-E-V-R-H-K-L-K-I-T-E-N-S-F-E-Q-I-T-F-M-Q-A-L-H-L-L-L-E-V-E-Q-E-I-R-T-F-S-F-Q-L-I


### FUNCTION Glutaredoxin necessary for virion morphogenesis and virus replication Functions as a thiol-disulfide transfer protein between membrane-associated OPG128 and substrates OPG095 or OPG053 The complete pathway for formation of disulfide bonds in intracellular virion membrane proteins sequentially involves oxidation of OPG072, OPG128 and OPG088 Exhibit thioltransferase and dehydroascorbate reductase activities in vitro ### SEQUENCE -M-K-N-V-L-I-I-F-G-K-P-Y-C-S-I-C-E-N-V-S-E-A-V-E-E-L-K-S-E-Y-D-I-L-H-V-D-I-L-S-F-F-L-K-D-G-D-S-S-M-L-G-D-V-K-R-G-T-L-I-G-N-F-A-A-H-L-S-N-Y-I-V-S-I-F-K-Y-N-P-Q-T-K-Q-M-A-F-V-D-I-N-K-S-L-D-F-T-K-T-D-K-S-L-V-N-L-E-I-L-K-S-E-I-E-K-A-N-Y-G-V-W-P-P-V-T-E


### FUNCTION Early protein involved in virion morphogenesis Participates in the formation and elongation of crescent-shaped membrane precursors of immature virions in cytoplasmic factories ### SEQUENCE -M-E-V-I-A-D-R-L-D-D-I-V-K-Q-N-I-A-D-E-K-F-V-D-F-V-I-H-G-L-E-H-Q-C-P-A-I-L-R-P-L-I-R-L-F-I-D-I-L-L-F-V-I-V-I-Y-I-F-T-V-R-L-V-S-R-N-Y-Q-M-L-L-A-L-V-A-L-V-I-T-L-T-I-F-Y-Y-F-I-L


### FUNCTION Mediates the nuclear export of encapsidated genomic RNAs  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain This domain is believed to allow recognition of RNPs bound to the protein M1 Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane May down-regulate viral RNA synthesis when overproduced ### SEQUENCE -M-D-S-N-T-V-S-S-F-Q-D-I-L-M-R-M-S-K-M-Q-L-G-S-S-S-E-D-L-N-G-M-I-T-Q-F-E-S-L-K-L-Y-R-D-S-L-G-E-A-V-M-R-M-G-D-L-H-S-L-Q-S-R-N-G-K-W-R-E-Q-L-S-Q-K-F-E-E-I-R-W-L-I-E-E-V-R-H-R-L-K-I-T-E-N-S-F-E-Q-I-T-F-M-Q-A-L-Q-L-L-L-E-V-E-Q-E-I-R-T-F-S-F-Q-L-I


### FUNCTION May self assemble to form a helical capsid wrapping up the viral genomic DNA The virion assembly and budding take place at the host inner membrane ### SEQUENCE -M-I-K-L-V-L-L-V-A-A-I-A-I-F-G-T-G-F-I-T-V-I-I-N-Q-F-T-S-A-K-N-I-I-M-D-L-Y-N-S-D-T-W-L-I-W-L-F-G-R-M-A-V-L-F-S-H-P-L-M-L-T-I-S-S-L-Y-I-V-G-F-I-V-S-K-T-L-Y-S


### FUNCTION Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry Also plays a role in cell-cell fusion ### SEQUENCE -M-T-D-E-Q-I-Y-A-F-C-D-A-N-K-D-D-I-R-C-K-C-I-Y-P-D-K-S-I-V-R-I-G-I-D-T-R-L-P-Y-Y-C-W-Y-E-P-C-K-R-S-D-A-L-L-P-A-S-L-K-K-N-I-T-K-C-N-V-S-D-C-T-I-S-L-G-N-V-S-I-T-D-S-K-L-D-V-N-N-V-C-D-S-K-R-V-A-T-E-N-I-A-V-R-Y-L-N-Q-E-I-R-Y-P-I-I-D-I-K-W-L-P-I-G-L-L-A-L-A-I-L-I-L-A-F-F


### FUNCTION The protein is truncated in this strain and presumably inactive It has similarities with variola virus CrmB, but the product is inactivated due to several premature stop codons ### SEQUENCE -M-K-S-V-L-Y-S-Y-I-L-F-L-S-C-I-I-I-N-G-R-D-I-A-P-H-A-P-S-D-G-K-C-K-D-N-E-Y-K-R-H-N-L-C-P-G-T-Y-A-S-R-L-C-D-S-K-T-N-T-Q-C-T-P-C-G-S-G-T-F-T-S-R-N-N-H-L-P-A-C-L-S-C-N-G-R-R-D-R-V-T-R-L-T-I-E-S-V-N-A-L-P-D-I-I-V-F-S-K-D-H-P-D-A-R-H-V-F-P-K-Q-N-V-E


### FUNCTION Participates in either intracellular transport of viral proteins or intercellular spread of the virus Cellular profilins modulate actin filament dynamics  In contrast to cellular homologs, the poxvirus profilins seem to bind actin only weakly ### SEQUENCE -M-A-E-W-H-K-I-I-E-D-I-S-K-N-N-K-F-E-D-A-A-I-V-D-Y-K-T-T-K-N-V-L-A-A-I-P-N-R-T-F-A-K-I-N-P-G-E-I-I-P-L-I-T-N-R-N-I-L-K-P-L-I-G-Q-K-Y-C-I-V-Y-T-N-S-L-M-D-E-N-T-Y-A-M-E-L-L-T-G-Y-A-P-V-S-P-I-V-I-A-R-T-H-T-A-L-I-F-L-M-G-K-P-T-T-S-R-R-D-V-Y-R-T-C-R-D-H-A-T-R-V-R-A-T-G-N


### FUNCTION Has thioltransferase and dehydroascorbate reductase activities ### SEQUENCE -M-A-E-E-F-V-Q-Q-R-L-A-N-N-K-V-T-I-F-V-K-Y-T-C-P-F-C-R-N-A-L-D-I-L-N-K-F-S-F-K-R-G-A-Y-E-I-V-D-I-K-E-F-K-P-E-N-E-L-R-D-Y-F-E-Q-I-T-G-G-R-T-V-P-R-I-F-F-G-K-T-S-I-G-G-Y-S-D-L-L-E-I-D-N-M-D-A-L-G-D-I-L-S-S-I-G-V-L-R-T-C


### FUNCTION Virulence factor that affects the acute immune response to infection Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation ### SEQUENCE -M-A-T-K-L-D-Y-E-D-A-V-F-Y-F-V-D-D-D-K-I-C-S-R-D-S-I-I-D-L-I-D-E-Y-I-T-W-R-N-H-V-I-V-F-N-K-D-I-T-S-C-G-R-L-Y-K-E-L-M-K-F-D-D-V-A-I-R-Y-Y-G-I-D-K-I-N-E-I-V-E-A-M-S-E-G-D-H-Y-I-N-F-T-K-V-H-D-Q-E-S-L-F-A-T-I-G-I-C-A-K-I-T-E-H-W-G-Y-K-K-I-S-E-S-R-F-Q-S-L-G-N-I-T-D-L-M-T-D-D-N-I-N-I-L-I-L-F-L-E-K-K-L-N


### FUNCTION Virion protein with no enzymatic activity ### SEQUENCE -M-A-V-C-I-I-D-H-D-N-I-R-G-V-I-Y-F-E-P-V-H-G-K-D-K-V-L-G-S-V-I-G-L-K-S-G-T-Y-N-L-I-I-H-R-Y-G-D-I-S-R-G-C-D-S-I-G-S-P-E-I-F-I-G-N-I-F-V-N-R-Y-G-V-A-Y-V-Y-L-D-T-D-V-N-I-S-T-I-I-G-K-A-L-S-I-S-K-N-N-Q-R-L-A-C-G-V-I-G-I-S-Y-I-N-E-K-I-I-H-F-L-T-I-N-E-N-G-V


### FUNCTION Has thioltransferase and dehydroascorbate reductase activities ### SEQUENCE -M-A-E-E-F-V-Q-Q-R-L-A-N-N-K-V-T-I-F-V-K-F-T-C-P-F-C-R-N-A-L-D-I-L-N-K-F-S-F-K-R-G-A-Y-E-I-V-D-I-K-E-F-K-P-E-N-E-L-R-D-Y-F-E-Q-I-T-G-G-R-T-V-P-R-I-F-F-G-K-T-S-I-G-G-Y-S-D-M-L-E-I-D-N-M-D-A-L-G-D-I-L-S-S-I-G-V-L-R-T-C


### FUNCTION This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA ### SEQUENCE -M-F-N-M-N-I-N-S-P-V-R-F-V-K-E-T-N-R-A-K-S-P-T-R-Q-S-P-Y-A-A-G-Y-D-L-Y-S-A-Y-Y-Y-T-I-P-P-G-E-R-Q-L-I-K-T-D-I-S-M-S-M-P-K-F-C-Y-G-R-I-A-P-R-S-G-L-S-L-K-G-I-D-I-G-G-G-V-I-D-E-D-Y-R-G-N-I-G-V-I-L-I-N-N-G-K-C-T-F-N-V-N-T-G-D-R-I-A-Q-L-I-Y-Q-R-I-Y-Y-P-E-L-K-E-V-Q-S-L-D-S-T-D-R-G-D-Q-G-F-G-S-T-G-L-R


### FUNCTION Stimulates cellular proliferation and mobility around infected cells to promote rapid and efficient spread of infection ### SEQUENCE -M-S-M-K-Y-L-M-L-L-F-A-T-M-I-I-R-S-F-A-D-S-G-N-A-I-E-T-T-S-P-E-I-T-N-T-T-T-D-I-P-A-I-R-L-C-G-P-E-G-D-G-Y-C-L-H-G-D-C-I-H-A-R-D-I-N-G-M-Y-C-R-C-S-H-G-Y-T-G-I-R-C-Q-H-V-V-L-V-D-Y-Q-R-S-E-K-P-N-T-T-T-S-Y-I-P-S-P-G-I-V-L-V-L-V-G-I-I-M-C-C-L-L-S-V-Y-R-F-T-R-R-T-N-K-L-P-L-Q-D-M-V-V-P


### FUNCTION The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide  in human intestinal microvilli ### SEQUENCE -M-K-K-T-L-L-I-A-A-S-L-S-F-F-S-A-S-A-L-A-T-P-D-C-V-T-G-K-V-E-Y-T-K-Y-N-D-D-D-T-F-T-V-K-V-G-D-K-E-L-F-T-N-R-W-N-L-Q-S-L-L-L-S-A-Q-I-T-G-M-T-V-T-I-K-T-N-A-C-H-N-G-G-G-F-S-E-V-I-F-R


### FUNCTION Suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing ### SEQUENCE -M-E-R-R-F-I-V-Y-Y-N-C-S-D-C-A-C-G-R-Y-V-S-S-L-L-T-M-S-G-A-Y-V-N-V-C-V-C-I-V-F-F-I-L-V-Y-L-S-S-C-Y-N-M-R-V-L-G-F-L-R-V-C-I-Y-L-Y-K-L-C-R


### FUNCTION Mediates the nuclear export of encapsidated genomic RNAs  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain This domain is believed to allow recognition of RNPs bound to the protein M1 Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane May down-regulate viral RNA synthesis when overproduced ### SEQUENCE -M-D-S-N-T-V-S-S-F-Q-D-I-L-M-R-M-S-K-M-Q-L-G-S-S-S-E-D-L-N-G-M-I-T-Q-F-E-S-L-K-L-Y-R-D-S-L-G-E-A-V-M-R-M-G-D-L-H-S-L-Q-N-R-N-G-K-W-R-E-Q-L-S-Q-K-F-E-E-I-R-W-L-I-E-E-V-R-H-R-L-K-I-T-E-N-S-F-E-Q-I-T-F-M-Q-A-L-Q-L-L-L-E-V-E-Q-E-I-R-T-F-S-F-Q-L-I


### FUNCTION Weak suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing , a mechanism of plant viral defense that performs sequence-specific inhibition of viral mRNAs expression This could be used by the virus to infect efficiently the host the meristem cells ### SEQUENCE -M-T-C-V-L-K-G-C-V-N-E-V-T-V-L-G-H-E-T-C-S-I-G-H-A-N-K-L-R-K-Q-V-A-D-M-V-G-V-T-R-R-C-A-E-N-N-C-G-W-F-V-C-V-V-I-N-D-F-T-F-D-V-Y-N-C-C-G-R-S-H-L-E-K-C-R-K-R-V-E-T-R-N-R-E-I-W-K-Q-I-R-R-N-Q-A-E-N-M-S-A-T-A-K-K-S-H-N-S-K-T-S-K-K-K-F-K-E-D-R-E-F-G-T-P-K-R-F-L-R-D-D-V-P-F-G-I-D-R-L-F-A-F


### FUNCTION Mediates the regulatory switch from transcription to RNA replication Acts late in infection by inhibiting viral transcription and up-regulating RNA replication Inhibition of transcription by protein M2-2 requires phosphorylation of the phosphoprotein ### SEQUENCE -M-N-N-S-N-I-I-I-F-P-E-K-Y-P-C-S-I-S-S-L-L-I-K-D-E-N-D-V-F-V-L-S-H-Q-N-V-L-D-C-L-Q-F-Q-Y-P-Y-N-M-Y-S-Q-N-H-M-L-D-D-I-Y-W-T-S-Q-E-L-I-E-D-V-L-K-I-L-H-L-S-G-I-S-I-N-K-Y-V-I-Y-V-L-V-L


### FUNCTION The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell Acts as a functional inhibitor of gH and maintains gH in an inhibited form Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH ### SEQUENCE -M-K-I-Y-R-V-L-V-H-L-S-F-V-L-G-M-F-T-K-T-N-T-V-L-A-W-S-K-Y-D-L-V-H-G-F-M-R-V-A-N-I-S-S-I-M-R-L-D-C-L-P-N-L-L-S-S-N-A-G-Y-A-A-L-P-S-D-D-I-P-T-G-I-F-I-K-V-N-C-S-I-P-E-F-I-L-W-Y-E-Q-K-A-M-A-A-W-I-N-P-I-M-G-T-V-L-M-M-N-D-V-L-K-S-G-L-E-N-S-V-K-V-G-L-L-T-F-L-K-R-I-A-E-K-G-P-N-G-P-L-R-N-R-G-S-G-C-I-N-L-I-A-P-A-D-I-S-C-Y-G-S-T-R-L-D-R-F-N-R-D-F-E-D-D-S-R-G-M-P-C-R-A-K-A-M-R-R-T-T-S-G-S-R-R-A-N-A


### FUNCTION Virion protein with no enzymatic activity ### SEQUENCE -M-A-V-C-I-I-D-H-D-N-I-R-G-V-I-Y-F-E-P-V-H-G-K-D-K-V-L-G-S-V-I-G-L-K-S-G-T-Y-S-L-I-I-H-R-Y-G-D-I-S-Q-G-C-D-S-I-G-S-P-E-I-F-I-G-N-I-F-V-N-R-Y-G-V-A-Y-V-Y-L-D-T-D-V-N-I-F-T-I-I-G-K-A-L-S-I-S-K-N-D-Q-R-L-A-C-E-V-I-G-I-S-Y-I-N-E-K-I-I-H-F-L-T-I-N-E-N-G-V


### FUNCTION Glutaredoxin necessary for virion morphogenesis and virus replication Functions as a thiol-disulfide transfer protein between membrane-associated OPG128 and substrates OPG095 or OPG053 The complete pathway for formation of disulfide bonds in intracellular virion membrane proteins sequentially involves oxidation of OPG072, OPG128 and OPG088 Exhibit thioltransferase and dehydroascorbate reductase activities in vitro ### SEQUENCE -M-K-N-V-L-I-I-F-G-K-P-Y-C-S-I-C-E-N-V-S-D-A-V-E-E-L-K-S-E-Y-D-I-L-H-V-D-I-L-S-F-F-L-K-D-G-D-S-S-M-L-G-D-V-K-R-G-T-L-I-G-N-F-A-A-H-L-S-N-Y-I-V-S-I-F-K-Y-N-P-Q-T-K-Q-M-A-F-V-D-I-N-K-S-L-D-F-T-K-T-D-K-S-L-V-N-L-E-I-L-K-S-E-I-E-K-A-N-Y-G-V-W-P-P-V-T-E


### FUNCTION Component of the entry fusion complex , which consists of 11 proteins During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation ### SEQUENCE -M-A-S-L-L-Y-L-I-L-F-L-L-F-V-C-I-S-Y-Y-F-T-Y-Y-P-T-N-K-L-Q-A-A-V-M-E-T-D-R-E-N-A-I-I-R-Q-R-N-D-E-I-P-T-R-T-L-D-T-A-I-F-T-D-A-S-T-V-A-S-A-Q-I-H-L-Y-Y-N-S-N-I-G-K-I-I-M-S-L-N-G-K-K-H-T-F-N-L-Y-D-D-N-D-I-R-T-L-L-P-I-L-L-L-S-K


### FUNCTION Mediates the nuclear export of encapsidated genomic RNAs  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain This domain is believed to allow recognition of RNPs bound to the protein M1 Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane May down-regulate viral RNA synthesis when overproduced ### SEQUENCE -M-D-S-N-T-V-S-S-F-Q-D-I-L-M-R-M-S-K-M-Q-L-G-S-S-S-E-D-L-N-G-M-I-I-R-L-E-S-L-K-L-Y-R-D-S-L-G-E-A-V-M-R-M-G-D-L-H-S-L-Q-S-R-N-E-K-W-R-E-Q-L-S-Q-K-F-E-E-I-R-W-L-I-E-E-V-R-H-R-L-K-N-T-E-N-S-F-E-Q-I-T-F-M-Q-A-L-Q-L-L-L-E-V-E-Q-E-I-R-T-F-S-F-Q-L-I


### FUNCTION Involved in protein trafficking May serve as a receptor for ARFRP1 ### SEQUENCE -M-A-G-Q-F-R-S-Y-V-W-D-P-L-L-I-L-S-Q-I-V-L-M-Q-T-V-Y-Y-G-S-L-G-L-W-L-A-L-V-D-A-L-V-R-S-S-P-S-L-D-Q-M-F-D-A-E-I-L-G-F-S-T-P-P-G-R-L-S-M-M-S-F-V-L-N-A-L-T-C-A-L-G-L-L-Y-F-I-R-R-G-K-Q-C-L-D-F-T-V-T-V-H-F-F-H-L-L-G-C-W-L-Y-S-S-R-F-P-S-A-L-T-W-W-L-V-Q-A-V-C-I-A-L-M-A-V-I-G-E-Y-L-C-M-R-T-E-L-K-E-I-P-L-S-S-A-P-K-S-N-V


### FUNCTION Guanidinium ion exporter Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons ### SEQUENCE -M-S-W-I-V-L-L-I-A-G-L-L-E-V-V-W-A-I-G-L-K-Y-T-H-G-F-T-R-L-T-P-S-I-I-T-I-A-A-M-I-V-S-I-A-M-L-S-W-A-M-R-T-L-P-V-G-T-A-Y-A-V-W-T-G-I-G-A-V-G-A-A-I-T-G-I-L-L-L-G-E-S-A-S-P-A-R-L-L-S-L-G-L-I-V-A-G-I-I-G-L-K-L-S-T-H


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation ### SEQUENCE -M-E-A-A-L-L-L-A-K-L-P-E-A-Y-Q-I-F-D-P-L-V-D-V-L-P-V-I-P-V-F-F-L-L-L-A-F-V-W-Q-A-A-V-G-F-R


### FUNCTION May play a pivotal role in the interaction between Mtuberculosis and host Can enhance the survival within macrophages under stress conditions such as H These changes probably involve the p38-ERK-NF-kappa-B signaling pathway Also precipitates the macrophage death ### SEQUENCE -M-S-F-V-M-A-Y-P-E-M-L-A-A-A-A-D-T-L-Q-S-I-G-A-T-T-V-A-S-N-A-A-A-A-A-P-T-T-G-V-V-P-P-A-A-D-E-V-S-A-L-T-A-A-H-F-A-A-H-A-A-M-Y-Q-S-V-S-A-R-A-A-A-I-H-D-Q-F-V-A-T-L-A-S-S-A-S-S-Y-A-A-T-E-V-A-N-A-A-A-A-S


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-A-N-S-I-Y-N-L-A-Q-A-D-A-L-P-L-E-S-G-N-S-I-L-F-P-P-L-Y-D-I-V-W-S-L-I-P-F-L-I-I-L-I-V-F-W-K-L-V-L-P-K-F-Q-E-V-L-T-E-R-E-D-R-I-K-G-G-I-Q-R-A-E-A-A-Q-A-E-A-K-A-A-L-E-K-Y-N-A-Q-L-A-E-A-R-T-E-A-A-E-I-R-E-Q-A-R-E-R-G-K-Q-I-E-A-E-L-K-D-K-A-N-E-E-S-N-R-I-I-E-S-G-S-K-Q-L-L-A-Q-R-E-Q-V-V-N-E-L-R-R-E-M-G-Q-N-S-I-N-L-A-E-H-L-L-G-D-Q-L-S-D-N-V-K-R-S-G-T-I-D-R-F-L-A-D-L-D-T-V-A-P-N-G-K


### FUNCTION Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine ### SEQUENCE -M-V-K-P-R-Q-R-E-Y-P-T-L-K-S-S-L-N-I-V-R-E-T-A-L-I-A-I-S-C-V-F-W-I-Y-C-L-V-V-L-L-V-Y-I-G-T-I-F-E-I-H-D-E-S-I-N-T-I-R-V-A-L-N-I-E-N-T-E-I-L-D-I-F-E-T-M-G-I-F-A-I-I-I-F-V-F-F-T-I-S-I-L-I-Q-K-W-Q-R-G-R-E-S


### FUNCTION Represses transcription of the icaADBC operon necessary for biofilm production ### SEQUENCE -M-K-D-K-I-I-D-N-A-I-T-L-F-S-E-K-G-Y-D-G-T-T-L-D-D-I-A-K-S-V-N-I-K-K-A-S-L-Y-Y-H-F-D-S-K-K-S-I-Y-E-Q-S-V-K-C-C-F-D-Y-L-N-N-I-I-M-M-N-Q-N-K-S-N-Y-S-I-D-A-L-Y-Q-F-L-F-E-F-I-F-D-I-E-E-R-Y-I-R-M-Y-V-Q-L-S-N-T-P-E-E-F-S-G-N-I-Y-G-Q-I-Q-D-L-N-Q-S-L-S-K-E-I-A-K-F-Y-D-E-S-K-I-K-M-T-K-E-D-F-Q-N-L-I-L-L-F-L-E-S-W-Y-L-K-A-S-F-S-Q-K-F-G-A-V-E-E-S-K-S-Q-F-K-D-E-V-Y-S-L-L-N-I-F-L-K-K


### FUNCTION Chaperone that serves for the intracellular sequestration and transport of Cu ### SEQUENCE -M-S-Q-E-I-L-N-V-E-G-M-S-C-G-H-C-K-S-A-V-E-S-A-L-N-N-I-D-G-V-T-S-A-D-V-N-L-E-N-G-Q-V-S-V-Q-Y-D-D-S-K-V-A-V-S-Q-M-K-D-A-I-E-D-Q-G-Y-D-V-V


### FUNCTION Transcriptional regulator acting as an intermediary between major regulators SarA and agr and virulence genes Represses alpha-hemolysin ### SEQUENCE -M-N-D-L-K-S-K-S-N-I-K-L-M-K-R-V-L-T-T-Y-E-L-R-K-Y-L-K-K-Y-F-C-L-T-L-D-N-Y-L-V-L-A-Y-L-D-V-F-K-N-D-E-G-K-Y-F-M-R-D-I-I-S-Y-I-G-I-D-Q-S-R-I-V-K-S-V-K-E-L-S-K-K-G-Y-L-N-K-C-R-D-P-H-D-S-R-N-V-I-I-V-V-S-V-K-Q-H-N-Y-I-K-N-L-L-S-E-I-N-I-N-E-T


### FUNCTION Negative regulator of sarA transcription at late exponential and stationary growth phases It contributes to the modulation of target genes downstream of the sarA regulatory cascade Also, positively regulates expression of primary transcripts RNAII and RNAIII generated by agr ### SEQUENCE -M-S-K-I-N-D-I-N-D-L-V-N-A-T-F-Q-V-K-K-F-F-R-D-T-K-K-K-F-N-L-N-Y-E-E-I-Y-I-L-N-H-I-L-R-S-E-S-N-E-I-S-S-K-E-I-A-K-C-S-E-F-K-P-Y-Y-L-T-K-A-L-Q-K-L-K-D-L-K-L-L-S-K-K-R-S-L-Q-D-E-R-T-V-I-V-Y-V-T-D-T-Q-K-A-N-I-Q-K-L-I-S-E-L-E-E-Y-I-K-N


### FUNCTION Involved in urease metallocenter assembly Binds nickel Probably functions as a nickel donor during metallocenter assembly ### SEQUENCE -M-I-V-E-E-I-Q-G-N-I-A-N-L-S-N-S-E-K-Q-K-H-V-E-K-V-Y-L-E-N-S-D-L-V-K-R-I-Q-R-V-V-T-D-H-G-T-E-I-G-I-R-L-K-Q-P-I-D-L-Q-Y-G-D-I-L-Y-A-D-D-H-N-M-I-I-V-D-V-N-S-E-D-L-L-V-I-Q-P-R-T-L-Q-E-M-G-D-I-A-H-Q-L-G-N-R-H-L-P-A-Q-F-T-E-T-E-M-L-V-Q-Y-D-Y-L-V-E-D-L-L-K-S-L-G-I-P-Y-V-R-E-D-R-K-V-N-K-A-F-R-H-I-G-H-S-H-D


### FUNCTION Part of the pathway by which MgrA and SarA control autolysis ### SEQUENCE -M-S-N-K-V-Q-R-F-I-E-A-E-R-E-L-S-Q-L-K-H-W-L-K-T-T-H-K-I-S-I-E-E-F-V-V-L-F-K-V-Y-E-A-E-K-I-S-G-K-E-L-R-D-T-L-H-F-E-M-L-W-D-T-S-K-I-D-V-I-I-R-K-I-Y-K-K-E-L-I-S-K-L-R-S-E-T-D-E-R-Q-V-F-Y-F-Y-S-T-S-Q-K-K-L-L-D-K-I-T-K-E-I-E-V-L-S-V-T-N


### FUNCTION One of the early assembly proteins it binds 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome Forms the main docking site for trigger factor binding to the ribosome ### SEQUENCE -M-E-A-R-D-I-L-K-R-P-V-I-T-E-K-S-S-E-A-M-A-E-D-K-Y-T-F-D-V-D-T-R-V-N-K-T-Q-V-K-M-A-V-E-E-I-F-N-V-K-V-A-S-V-N-I-M-N-Y-K-P-K-K-K-R-M-G-R-Y-Q-G-Y-T-N-K-R-R-K-A-I-V-T-L-K-E-G-S-I-D-L-F-N


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-E-A-K-A-V-A-R-T-I-R-I-A-P-R-K-V-R-L-V-L-D-L-I-R-G-K-N-A-A-E-A-I-A-I-L-K-L-T-N-K-A-S-S-P-V-I-E-K-V-L-M-S-A-L-A-N-A-E-H-N-Y-D-M-N-T-D-E-L-V-V-K-E-A-Y-A-N-E-G-P-T-L-K-R-F-R-P-R-A-Q-G-R-A-S-A-I-N-K-R-T-S-H-I-T-I-V-V-S-D-G-K-E-E-A-K-E-A


### FUNCTION Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs ### SEQUENCE -M-L-L-P-K-R-V-K-Y-R-R-Q-H-R-P-K-T-T-G-R-S-K-G-G-N-Y-V-T-F-G-E-F-G-L-Q-A-T-T-T-S-W-I-T-S-R-Q-I-E-S-A-R-I-A-M-T-R-Y-M-K-R-G-G-K-V-W-I-K-I-F-P-H-T-P-Y-T-K-K-P-L-E-V-R-M-G-A-G-K-G-A-V-E-G-W-I-A-V-V-K-P-G-R-I-L-F-E-V-A-G-V-S-E-E-V-A-R-E-A-L-R-L-A-S-H-K-L-P-V-K-T-K-F-V-K-R-E-E-L-G-G-E-T-N-E-S


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-Q-E-T-R-L-K-V-A-D-N-S-G-A-R-E-V-L-T-I-K-V-L-G-G-S-G-R-K-T-A-N-I-G-D-V-I-V-C-T-V-K-N-A-T-P-G-G-V-V-K-K-G-D-V-V-K-A-V-I-V-R-T-K-S-G-V-R-R-N-D-G-S-Y-I-K-F-D-E-N-A-C-V-I-I-R-D-D-K-G-P-R-G-T-R-I-F-G-P-V-A-R-E-L-R-E-G-N-F-M-K-I-V-S-L-A-P-E-V-L


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-N-R-L-K-E-K-F-N-T-E-V-T-E-N-L-M-K-K-F-N-Y-S-S-V-M-E-V-P-K-I-D-K-I-V-V-N-M-G-V-G-D-A-V-Q-N-S-K-V-L-D-N-A-V-E-E-L-E-L-I-T-G-Q-K-P-L-V-T-K-A-K-K-S-I-A-T-F-R-L-R-E-G-M-P-I-G-A-K-V-T-L-R-G-E-R-M-Y-E-F-L-D-K-L-I-S-V-S-L-P-R-V-R-D-F-Q-G-V-S-K-K-A-F-D-G-R-G-N-Y-T-L-G-V-K-E-Q-L-I-F-P-E-I-D-Y-D-K-V-S-K-V-R-G-M-D-I-V-I-V-T-T-A-N-T-D-E-E-A-R-E-L-L-A-N-F-G-M-P-F-R-K


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-S-R-V-G-K-K-I-I-D-I-P-S-D-V-T-V-T-F-D-G-N-H-V-T-V-K-G-P-K-G-E-L-S-R-T-L-N-E-R-M-T-F-K-Q-E-E-N-T-I-E-V-V-R-P-S-D-S-K-E-D-R-T-N-H-G-T-T-R-A-L-L-N-N-M-V-Q-G-V-S-Q-G-Y-V-K-V-L-E-L-V-G-V-G-Y-R-A-Q-M-Q-G-K-D-L-I-L-N-V-G-Y-S-H-P-V-E-I-K-A-E-E-N-I-T-F-S-V-E-K-N-T-V-V-K-V-E-G-I-S-K-E-Q-V-G-A-L-A-S-N-I-R-S-V-R-P-P-E-P-Y-K-G-K-G-I-R-Y-Q-G-E-Y-V-R-R-K-E-G-K-T-G-K


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-I-S-K-I-D-K-N-K-V-R-L-K-R-H-A-R-V-R-T-N-L-S-G-T-A-E-K-P-R-L-N-V-Y-R-S-N-K-H-I-Y-A-Q-I-I-D-D-N-K-G-V-T-L-A-Q-A-S-S-K-D-S-D-I-A-T-T-A-T-K-V-E-L-A-T-K-V-G-E-A-I-A-K-K-A-A-D-K-G-I-K-E-I-V-F-D-R-G-G-Y-L-Y-H-G-R-V-K-A-L-A-E-A-A-R-E-S-G-L-E-F


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-R-Q-T-F-M-A-N-E-S-N-I-E-R-K-W-Y-V-I-D-A-E-G-Q-T-L-G-R-L-S-S-E-V-A-S-I-L-R-G-K-N-K-V-T-Y-T-P-H-V-D-T-G-D-Y-V-I-V-I-N-A-S-K-I-E-F-T-G-N-K-E-T-D-K-V-Y-Y-R-H-S-N-H-P-G-G-I-K-S-I-T-A-G-E-L-R-R-T-N-P-E-R-L-I-E-N-S-I-K-G-M-L-P-S-T-R-L-G-E-K-Q-G-K-K-L-F-V-Y-G-G-A-E-H-P-H-A-A-Q-Q-P-E-N-Y-E-L-R-G


### FUNCTION Dephosphorylates the phosphotyrosine-containing proteins ### SEQUENCE -M-K-I-L-F-V-C-T-G-N-T-C-R-S-P-L-A-E-S-I-A-K-E-V-M-P-N-H-Q-F-E-S-R-G-I-F-A-V-N-N-Q-G-V-S-N-Y-V-E-D-L-V-E-E-H-H-L-A-E-T-T-L-S-Q-Q-F-T-E-A-D-L-K-A-D-I-I-L-T-M-S-Y-S-H-K-E-L-I-E-A-H-F-G-L-Q-N-H-V-F-T-L-H-E-Y-V-K-E-A-G-E-V-I-D-P-Y-G-G-T-K-E-M-Y-V-H-T-Y-E-E-L-V-S-L-I-L-K-L-K-D-I-I-C


### FUNCTION F is coupled via a rotary mechanism of the central stalk subunits to proton translocation ### SEQUENCE -M-T-E-T-A-N-L-F-V-L-G-A-A-G-G-V-E-W-G-T-V-I-V-Q-V-L-T-F-I-V-L-L-A-L-L-K-K-F-A-W-G-P-L-K-D-V-M-D-K-R-E-R-D-I-N-R-D-I-D-D-A-E-Q-A-K-L-N-A-Q-K-L-E-E-E-N-K-Q-K-L-K-E-T-Q-E-E-V-Q-K-I-L-E-D-A-K-V-Q-A-R-Q-Q-Q-E-Q-I-I-H-E-A-N-V-R-A-N-G-M-I-E-T-A-Q-S-E-I-N-S-Q-K-E-R-A-I-A-D-I-N-N-Q-V-S-E-L-S-V-L-I-A-S-K-V-L-R-K-E-I-S-E-Q-D-Q-K-A-L-V-D-K-Y-L-K-E-A-G-D-K


### FUNCTION Antitoxin component of a type II toxin-antitoxin  system Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity ### SEQUENCE -M-L-S-F-S-Q-N-R-S-H-S-L-E-Q-S-L-K-E-G-Y-S-Q-M-A-D-L-N-L-S-L-A-N-E-A-F-P-I-E-C-E-A-C-D-C-N-E-T-Y-L-S-S-N-S-T-N-E


### FUNCTION Toxic component of a type II toxin-antitoxin  system Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA Neutralized by coexpression with cognate antitoxin MazE ### SEQUENCE -M-I-R-R-G-D-V-Y-L-A-D-L-S-P-V-Q-G-S-E-Q-G-G-V-R-P-V-V-I-I-Q-N-D-T-G-N-K-Y-S-P-T-V-I-V-A-A-I-T-G-R-I-N-K-A-K-I-P-T-H-V-E-I-E-K-K-K-Y-K-L-D-K-D-S-V-I-L-L-E-Q-I-R-T-L-D-K-K-R-L-K-E-K-L-T-Y-L-S-D-D-K-M-K-E-V-D-N-A-L-M-I-S-L-G-L-N-A-V-A-H-Q-K-N


### FUNCTION Involved in countering the first line of host defense mechanisms Efficiently inhibits opsonization, phagocytosis and killing of Saureus by human neutrophils Acts by binding and stabilizing human C3 convertases ### SEQUENCE -M-K-I-R-K-S-I-L-A-G-T-L-A-I-V-L-A-S-P-L-V-T-N-L-D-K-N-E-A-Q-A-S-T-S-L-P-T-S-N-E-Y-Q-N-E-K-L-A-N-E-L-K-S-L-L-D-E-L-N-V-N-E-L-A-T-G-S-L-N-T-Y-Y-K-R-T-I-K-I-S-G-Q-K-A-M-Y-A-L-K-S-K-D-F-K-K-M-S-E-A-K-Y-Q-L-Q-K-I-Y-N-E-I-D-E-A-L-K-S-K-Y


### FUNCTION Secreted tyrosine phosphatase that plays a critical role during infection as a bacterial effector protein that counteracts host defenses Required for intramacrophage survival ### SEQUENCE -M-V-D-V-A-F-V-C-L-G-N-I-C-R-S-P-M-A-E-A-I-M-R-Q-R-L-K-D-R-N-I-H-D-I-K-V-H-S-R-G-T-G-S-W-N-L-G-E-P-P-H-E-G-T-Q-K-I-L-N-K-H-N-I-P-F-D-G-M-I-S-E-L-F-E-A-T-D-D-F-D-Y-I-V-A-M-D-Q-S-N-V-D-N-I-K-S-I-N-P-N-L-K-G-Q-L-F-K-L-L-E-F-S-N-M-E-E-S-D-V-P-D-P-Y-Y-T-N-N-F-E-G-V-Y-D-M-V-L-S-S-C-D-N-L-I-D-Y-I-V-K-D-A-N-L-K-E-G


### FUNCTION Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins May act as a hydrogen peroxide and organic hydroperoxide sensor ### SEQUENCE -M-S-V-E-I-E-S-I-E-H-E-L-E-E-S-I-A-S-L-R-Q-A-G-V-R-I-T-P-Q-R-Q-A-I-L-R-Y-L-I-S-S-H-T-H-P-T-A-D-E-I-Y-Q-A-L-S-P-D-F-P-N-I-S-V-A-T-I-Y-N-N-L-R-V-F-K-D-I-G-I-V-K-E-L-T-Y-G-D-S-S-S-R-F-D-F-N-T-H-N-H-Y-H-I-I-C-E-Q-C-G-K-I-V-D-F-Q-Y-P-Q-L-N-E-I-E-R-L-A-Q-H-M-T-D-F-D-V-T-H-H-R-M-E-I-Y-G-V-C-K-E-C-Q-D-K


### FUNCTION Global regulator with both positive and negative effects that mediates modulation of several genes involved in virulence Also, modulates the expression of genes not previously implicated in pathogenesis ### SEQUENCE -M-H-K-L-A-H-T-S-F-G-I-V-G-M-F-V-N-T-C-M-V-A-K-Y-V-I-I-N-W-E-M-F-S-M-K-K-V-N-N-D-T-V-F-G-I-L-Q-L-E-T-L-L-G-D-I-N-S-I-F-S-E-I-E-S-E-Y-K-M-S-R-E-E-I-L-I-L-L-T-L-W-Q-K-G-S-M-T-L-K-E-M-D-R-F-V-E-V-K-P-Y-K-R-T-R-T-Y-N-N-L-V-E-L-E-W-I-Y-K-E-R-P-V-D-D-E-R-T-V-I-I-H-F-N-E-K-L-Q-Q-E-K-V-E-L-L-N-F-I-S-D-A-I-A-S-R-A-T-A-M-Q-N-S-L-N-A-I-I-A-V


### FUNCTION This protein binds to 23S rRNA in the presence of protein L20 ### SEQUENCE -M-F-A-I-I-E-T-G-G-K-Q-I-K-V-E-E-G-Q-E-I-F-V-E-K-L-D-V-N-E-G-D-T-F-T-F-D-K-V-L-F-V-G-G-D-S-V-K-V-G-A-P-T-V-E-G-A-T-V-T-A-T-V-N-K-Q-G-R-G-K-K-I-T-V-F-T-Y-K-R-R-K-N-S-K-R-K-K-G-H-R-Q-P-Y-T-K-L-T-I-D-K-I-N-A


### FUNCTION Binds directly to 16S ribosomal RNA ### SEQUENCE -M-A-N-I-K-S-A-I-K-R-V-K-T-T-E-K-A-E-A-R-N-I-S-Q-K-S-A-M-R-T-A-V-K-N-A-K-T-A-V-S-N-N-A-D-N-K-N-E-L-V-S-L-A-V-K-L-V-D-K-A-A-Q-S-N-L-I-H-S-N-K-A-D-R-I-K-S-Q-L-M-T-A-N-K


### FUNCTION Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions ### SEQUENCE -M-N-K-T-D-L-I-N-A-V-A-E-Q-A-D-L-T-K-K-E-A-G-S-A-V-D-A-V-F-E-S-I-Q-N-S-L-A-K-G-E-K-V-Q-L-I-G-F-G-N-F-E-V-R-E-R-A-A-R-K-G-R-N-P-Q-T-G-K-E-I-D-I-P-A-S-K-V-P-A-F-K-A-G-K-A-L-K-D-A-V-K


### FUNCTION Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed Also contributes to the recruitment of PBP1 to the division complex Not essential for septum formation ### SEQUENCE -M-S-D-V-S-L-K-L-S-A-K-D-I-Y-E-K-D-F-E-K-T-M-A-R-G-Y-R-R-E-E-V-D-A-F-L-D-D-I-I-A-D-Y-Q-K-M-A-D-M-N-N-E-V-V-K-L-S-E-E-N-H-K-L-K-K-E-L-E-E-L-R-L-R-V-A-T-S-R-P-Q-D-N-K-S-F-S-S-N-N-T-T-T-N-T-S-S-N-N-V-D-I-L-K-R-I-S-N-L-E-K-A-V-F-G-K


### FUNCTION Involved in cold stress response ### SEQUENCE -M-K-Q-G-T-V-K-W-F-N-A-E-K-G-F-G-F-I-E-V-E-G-E-N-D-V-F-V-H-F-S-A-I-N-Q-D-G-Y-K-S-L-E-E-G-Q-A-V-E-F-E-V-V-E-G-D-R-G-P-Q-A-A-N-V-V-K-L


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA ### SEQUENCE -M-A-I-S-Q-E-R-K-N-E-I-I-K-E-Y-R-V-H-E-T-D-T-G-S-P-E-V-Q-I-A-V-L-T-A-E-I-N-A-V-N-E-H-L-R-T-H-K-K-D-H-H-S-R-R-G-L-L-K-M-V-G-R-R-R-H-L-L-N-Y-L-R-S-K-D-I-Q-R-Y-R-E-L-I-K-S-L-G-I-R-R


### FUNCTION Cell division protein that is part of the divisome complex and is recruited early to the Z-ring Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments Its function overlaps with FtsA ### SEQUENCE -M-S-H-L-A-L-K-D-L-F-S-G-F-F-V-I-D-D-E-E-E-V-E-V-P-D-K-Q-Q-Q-V-N-E-A-P-A-K-E-Q-S-Q-Q-T-T-K-Q-N-A-I-K-S-V-P-Q-K-S-A-S-R-Y-T-T-T-S-E-E-R-N-N-R-M-S-N-Y-S-K-N-N-S-R-N-V-V-T-M-N-N-A-T-P-N-N-A-S-Q-E-S-S-K-M-C-L-F-E-P-R-V-F-S-D-T-Q-D-I-A-D-E-L-K-N-R-R-A-T-L-V-N-L-Q-R-I-D-K-V-S-A-K-R-I-I-D-F-L-S-G-T-V-Y-A-I-G-G-D-I-Q-R-V-G-T-D-I-F-L-C-T-P-D-N-V-E-V-A-G-S-I-T-D-H-I-E-N-M-E-H-S-F-D


### FUNCTION Catalyzes quinol oxidation with the concomitant reduction of oxygen to water ### SEQUENCE -M-S-T-I-M-K-H-T-V-G-F-I-A-S-I-V-L-T-L-L-A-V-Y-V-T-L-Y-T-S-L-T-F-H-A-K-L-T-I-I-F-G-F-A-F-V-Q-A-G-L-Q-L-L-M-F-M-H-L-T-E-G-K-D-G-R-L-Q-T-F-K-V-I-F-A-L-V-I-T-L-C-F-V-V-G-T-Y-W-V-M-Q-G-G-H-S-S-H-L


### FUNCTION Specifically inhibits the cysteine protease staphopain B ### SEQUENCE -M-Y-Q-L-Q-F-I-N-L-V-Y-D-T-T-K-L-T-H-L-E-Q-T-N-I-N-L-F-I-G-N-W-S-N-H-Q-L-Q-K-S-I-C-I-R-H-G-D-D-T-S-H-N-Q-Y-H-I-L-F-I-D-T-A-H-Q-R-I-K-F-S-S-I-D-N-E-E-I-I-Y-I-L-D-Y-D-D-T-Q-H-I-L-M-Q-T-S-S-K-Q-G-I-G-T-S-R-P-I-V-Y-E-R-L-V


### FUNCTION PPIases accelerate the folding of proteins It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ### SEQUENCE -M-A-N-Y-P-Q-L-N-K-E-V-Q-Q-G-E-I-K-V-V-M-H-T-N-K-G-D-M-T-F-K-L-F-P-N-I-A-P-K-T-V-E-N-F-V-T-H-A-K-N-G-Y-Y-D-G-I-T-F-H-R-V-I-N-D-F-M-I-Q-G-G-D-P-T-A-T-G-M-G-G-E-S-I-Y-G-G-A-F-E-D-E-F-S-L-N-A-F-N-L-Y-G-A-L-S-M-A-N-S-G-P-N-T-N-G-S-Q-F-F-I-V-Q-M-K-E-V-P-Q-N-M-L-S-Q-L-A-D-G-G-W-P-Q-P-I-V-D-A-Y-G-E-K-G-G-T-P-W-L-D-Q-K-H-T-V-F-G-Q-I-I-D-G-E-T-T-L-E-D-I-A-N-T-K-V-G-P-Q-D-K-P-L-H-D-V-V-I-E-S-I-D-V-E-E


### FUNCTION Involved in protein export Participates in an early event of protein translocation ### SEQUENCE -M-H-T-F-L-I-V-L-L-I-I-D-C-I-A-L-I-T-V-V-L-L-Q-E-G-K-S-S-G-L-S-G-A-I-S-G-G-A-E-Q-L-F-G-K-Q-K-Q-R-G-V-D-L-F-L-N-R-L-T-I-I-L-S-I-L-F-F-V-L-M-I-C-I-S-Y-L-G-M


### FUNCTION Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase ### SEQUENCE -M-I-R-F-E-I-H-G-D-N-L-T-I-T-D-A-I-R-N-Y-I-E-E-K-I-G-K-L-E-R-Y-F-N-D-V-P-N-A-V-A-H-V-K-V-K-T-Y-S-N-S-A-T-K-I-E-V-T-I-P-L-K-N-V-T-L-R-A-E-E-R-N-D-D-L-Y-A-G-I-D-L-I-N-N-K-L-E-R-Q-V-R-K-Y-K-T-R-I-N-R-K-S-R-D-R-G-D-Q-E-V-F-V-A-E-L-Q-E-M-Q-E-T-Q-V-D-N-D-A-Y-D-D-N-E-I-E-I-I-R-S-K-E-F-S-L-K-P-M-D-S-E-E-A-V-L-Q-M-N-L-L-G-H-D-F-F-V-F-T-D-R-E-T-D-G-T-S-I-V-Y-R-R-K-D-G-K-Y-G-L-I-Q-T-S-E-Q


### FUNCTION Regulatory protein involved in autolytic activity, multidrug resistance and virulence ### SEQUENCE -M-S-D-Q-H-N-L-K-E-Q-L-C-F-S-L-Y-N-A-Q-R-Q-V-N-R-Y-Y-S-N-K-V-F-K-K-Y-N-L-T-Y-P-Q-F-L-V-L-T-I-L-W-D-E-S-P-V-N-V-K-K-V-V-T-E-L-A-L-D-T-G-T-V-S-P-L-L-K-R-M-E-Q-V-D-L-I-K-R-E-R-S-E-V-D-Q-R-E-V-F-I-H-L-T-D-K-S-E-T-I-R-P-E-L-S-N-A-S-D-K-V-A-S-A-S-S-L-S-Q-D-E-V-K-E-L-N-R-L-L-G-K-V-I-H-A-F-D-E-T-K-E-K


### FUNCTION Involved in the regulation of virulence genes Acts as a repressor of the agr locus and consequently targets genes regulated by the agr system such as sspA, hla and hlb Binds directly to the agr promoter region ### SEQUENCE -M-N-T-E-K-L-E-T-L-L-G-F-Y-K-Q-Y-K-A-L-S-E-Y-I-D-K-K-Y-K-L-S-L-N-D-L-A-V-L-D-L-T-M-K-H-C-K-D-E-K-V-L-M-Q-S-F-L-K-T-A-M-D-E-L-D-L-S-R-T-K-L-L-V-S-I-R-R-L-I-E-K-E-R-L-S-K-V-R-S-S-K-D-E-R-K-I-Y-I-Y-L-N-N-D-D-I-S-K-F-N-A-L-F-E-D-V-E-Q-F-L-N-I