### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-K-E-Q-K-W-I-H-E-G-L-I-T-E-S-L-P-N-G-M-F-R-I-R-L-D-N-E-D-M-I-L-G-Y-V-S-G-K-I-R-R-S-F-I-R-I-L-P-G-D-R-V-K-I-E-V-S-R-Y-D-S-T-R-G-R-I-I-Y-R-L-R-N-K-N-S-K-D


### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-K-E-Q-K-W-I-N-E-G-L-I-T-E-S-L-P-N-G-M-F-R-V-R-L-D-N-E-D-L-S-L-G-Y-V-S-G-K-I-R-R-S-F-I-R-V-L-P-G-D-R-V-K-I-E-V-S-R-Y-D-S-T-R-G-R-I-I-Y-R-L-R-N-K-D-S-K-D


### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-K-E-Q-K-W-I-H-E-G-L-I-T-E-S-L-P-N-G-M-F-R-V-R-L-D-N-E-D-F-I-L-G-Y-I-S-G-R-I-R-R-S-F-I-R-I-L-P-G-D-R-V-K-I-E-I-S-R-Y-D-S-T-R-G-R-I-I-Y-R-L-R-N-K-D-S-N-Y


### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-K-E-Q-K-W-V-H-E-G-L-I-T-E-S-L-P-N-G-M-F-R-V-R-L-D-N-E-D-L-I-L-G-Y-I-S-G-R-I-R-R-S-F-I-R-I-L-P-G-D-R-V-K-I-E-V-S-R-Y-D-S-T-R-G-R-I-I-Y-R-L-R-N-K-D-S-N-D


### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-K-E-Q-K-L-I-H-E-G-L-I-I-E-S-L-P-N-G-M-F-R-V-R-L-D-N-E-D-L-I-L-G-Y-V-S-G-R-I-R-R-S-F-I-R-I-L-P-G-D-R-V-K-I-E-V-S-R-Y-D-S-T-R-G-R-I-I-Y-R-L-R-N-K-D-S-N-D


### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-K-E-Q-K-W-I-H-E-G-L-I-T-E-S-L-P-N-G-M-F-R-V-R-L-D-N-V-D-N-E-D-L-I-L-G-Y-V-S-G-R-I-R-R-S-F-I-R-I-L-P-G-X-R-V-K-I-E-V-S-R-X-D-S-T-R-G-R-I-I-Y-R-L-R-N-K-D-S-N-B


### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-K-E-Q-K-L-I-H-E-G-L-I-T-E-S-L-P-N-G-M-F-W-V-R-L-D-N-E-D-L-V-L-G-Y-V-S-G-R-I-R-R-S-F-I-R-I-L-P-G-D-R-V-K-I-E-V-S-R-Y-D-S-T-R-G-R-I-I-Y-R-L-R-N-K-D-S-N-D


### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-K-E-Q-K-L-I-H-E-G-L-I-T-E-S-L-P-N-G-M-F-Q-V-R-L-D-N-G-D-L-V-L-G-Y-V-S-G-R-I-R-R-S-F-I-R-I-L-P-G-D-R-V-K-I-E-V-S-R-Y-D-S-T-R-G-R-I-I-Y-R-L-R-N-K-D-S-N-D


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-T-S-F-K-L-V-K-Y-I-P-R-I-K-K-K-K-S-G-L-R-K-L-A-R-K-V-P-T-D-R-L-L-K-F-E-R-V-F-K-A-Q-K-R-I-P-M-S-V-F-K-A-Q-R-V-L-D-E-I-R-W-R-Y-Y-E-E-T-V-M-I-L-N-L-M-P-Y-R-A-S-Y-P-I-L-K-L-V-Y-S-A-A-A-N-A-T-H-Y-R-D-F-D-K-A-N-L-F-I-T-K-A-E-V-S-R-S-T-I-M-K-K-F-R-P-R-A-R-G-R-S-F-P-I-K-K-S-M-C-H-I-T-I-V-L-N-I-V-K-K-S


### FUNCTION Binds to 23S rRNA ### SEQUENCE -M-I-Q-P-Q-T-L-L-N-V-A-D-N-S-G-A-R-K-L-M-C-I-R-V-I-G-A-A-G-N-Q-R-Y-A-R-I-G-D-V-I-V-A-V-I-K-D-A-L-P-Q-M-P-L-E-R-S-E-V-I-R-A-V-I-V-R-T-C-K-E-F-K-C-E-D-G-I-I-I-R-Y-D-D-N-A-A-V-I-I-D-Q-K-G-N-P-K-G-T-R-V-F-G-A-I-A-E-E-L-R-G-L-N-F-T-K-I-V-S-L-A-P-E-V-L


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-G-K-D-T-I-A-D-L-L-T-S-I-R-N-A-D-M-N-K-K-G-T-V-R-V-V-S-T-N-I-T-E-N-I-V-K-I-L-L-R-E-G-F-I-E-S-V-R-K-H-Q-E-R-N-R-Y-F-L-V-S-T-L-R-H-Q-K-R-K-T-R-K-G-I-Y-R-T-R-T-F-L-K-R-I-S-R-P-G-L-R-I-Y-T-N-Y-Q-G-I-P-K-V-L-G-G-M-G-I-A-I-L-S-T-S-R-G-I-M-T-D-R-E-A-R-L-N-R-I-G-G-E-V-L-C-Y-I-W


### FUNCTION Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit It is not involved in the protein synthesizing functions of that subunit ### SEQUENCE -M-T-R-V-P-R-G-Y-I-A-R-R-R-R-T-K-M-R-S-F-A-S-N-F-R-G-A-H-L-R-L-N-R-M-I-T-Q-Q-V-K-R-A-F-V-S-S-H-R-D-R-G-R-Q-K-R-D-F-R-R-L-W-I-T-R-I-N-A-A-T-R-V-Y-K-V-F-D-S-Y-S-K-L-I-H-N-L-Y-K-K-K-L-I-L-N-R-K-M-L-A-Q-V-A-V-S-N-P-N-N-L-Y-T-I-S-N-K-I-K-I-I-N


### FUNCTION One of the components of the core complex of photosystem II  and a proton gradient subsequently used for ATP formation It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation ### SEQUENCE -M-S-D-T-T-G-R-I-P-L-C-L-I-G-T-V-A-G-I-A-V-I-G-L-V-G-V-F-F-Y-G-S-Y-S-G-L-G-S-S-L


### FUNCTION Binds 16S rRNA, required for the assembly of 30S particles ### SEQUENCE -M-A-K-K-S-L-I-Q-R-E-K-K-R-Q-K-L-E-Q-K-Y-H-L-I-R-Q-S-L-K-K-K-I-R-S-K-V-S-P-L-S-L-S-E-K-T-K-M-R-E-K-L-Q-S-L-P-R-N-S-A-P-T-R-L-H-R-R-C-F-L-T-G-R-P-R-A-N-Y-R-H-F-G-L-S-G-H-V-L-R-E-M-V-Y-E-C-L-L-P-G-A-T-R-S-S-W


### FUNCTION Has an antimicrobial activity ### SEQUENCE -M-W-H-L-K-L-F-A-V-L-V-I-C-L-L-L-A-V-Q-V-H-G-S-P-I-P-E-L-S-S-A-K-R-R-P-R-R-M-T-P-F-W-R-A-V-S-L-R-P-I-G-A-S-C-R-D-D-S-E-C-L-T-R-L-C-R-K-R-R-C-S-L-S-V-A-Q-E


### FUNCTION May play a role in neurogenesis May play a role in bone differentiation and matrix mineralization ### SEQUENCE -M-A-L-H-I-H-E-A-C-I-L-L-L-V-I-P-G-L-V-T-S-A-A-I-S-H-E-D-Y-P-A-D-E-G-D-Q-I-S-S-N-D-N-L-I-F-D-D-Y-R-G-K-G-C-V-D-D-S-G-F-V-Y-K-L-G-E-R-F-F-P-G-H-S-N-C-P-C-V-C-A-L-D-G-P-V-C-D-Q-P-E-C-P-K-I-H-P-K-C-T-K-V-E-H-N-G-C-C-P-E-C-K-E-V-K-N-F-C-E-Y-H-G-K-N-Y-K-I-L-E-E-F-K-V-C-V-T-L-H-T-Y


### FUNCTION Displays low GTPase activity and exists predominantly in the GTP-bound form ### SEQUENCE -M-P-E-Q-S-N-D-Y-R-V-A-V-F-G-A-G-G-V-G-K-S-S-L-V-L-R-F-V-K-G-T-F-R-E-S-Y-I-P-T-V-E-D-T-Y-R-Q-V-I-S-C-D-K-S-I-C-T-L-Q-I-T-D-T-T-G-S-H-Q-F-P-A-M-Q-R-L-S-I-S-K-G-H-A-F-I-L-V-Y-S-I-T-S-R-Q-S-L-E-E-L-K-P-I-Y-E-Q-I-C-E-I-K-G-D-M-E-S-I-P-I-M-L-V-G-N-K-C-D-E-S-P-S-R-E-V-Q-S-S-E-A-E-A-L-A-R-T-W-K-C-A-F-M-E-T-S-A-K-L-N-H-N-V-K-E-L-F-Q-E-L-L-N-L-E-K-R-R-T-V-S-L-Q-I-D-G-K-K-S-K-Q-Q-K-R-K-E-K-L-K-G-K-C-V-I-M


### FUNCTION Plays a role as a glutathione ### SEQUENCE -M-G-V-A-V-R-V-V-Y-C-G-A-U-G-Y-K-S-K-Y-L-Q-L-K-K-K-L-E-D-E-F-P-G-R-L-D-I-C-G-E-G-T-P-Q-V-T-G-F-F-E-V-L-V-A-G-K-L-V-H-S-K-K-G-G-D-G-Y-V-D-T-E-S-K-F-L-K-L-V-A-A-I-K-A-A-L-A-Q-G


### FUNCTION Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells ### SEQUENCE -M-Y-K-I-Q-L-L-S-C-I-A-L-T-L-A-L-V-A-N-G-A-P-T-S-S-S-T-G-N-T-M-K-E-V-K-S-L-L-L-D-L-Q-L-L-L-E-K-V-K-N-P-E-N-L-K-L-S-R-M-H-T-F-N-F-Y-V-P-K-V-N-A-T-E-L-K-H-L-K-C-L-L-E-E-L-K-L-L-E-E-V-L-N-L-A-P-S-K-N-L-N-P-R-E-I-K-D-S-M-D-N-I-K-R-I-V-L-E-L-Q-G-S-E-T-G-F-T-C-E-Y-D-D-A-T-V-K-A-V-E-F-L-N-K-W-I-T-F-C-Q-S-I-Y-S-T-M-T


### FUNCTION Involved in signal transduction through the Wnt pathway Promotes beta-catenin's transcriptional activity ### SEQUENCE -P-M-G-M-T-Q-P-L-S-H-S-N-Q-M-P-S-P-N-A-M-G-P-N-I-P-P-H-G-V-P-M-G-P-G-L-M-S-H-N-P-I-M-G-H-G-S-Q-E-P-P-M-V-P-Q-G-R-M-G-F-P-Q-G-F-P-P-V-Q-S-P-P-Q-Q-V-P-F-P-H-N-G-P-S-G-G-Q-G-N-F-P-G-G-M-G-F-P-G-E-G-P-L-G-R-P-S-N-L-P-Q-S-S-A-D-A-A-L-C-K-P-G-G-P-G-G-P-D-S-F-A-V-L-G


### FUNCTION May play a role in cell differentiation in the intestinal epithelium ### SEQUENCE -M-A-D-S-E-R-L-S-A-P-G-C-W-A-A-C-T-T-F-S-R-T-R-K-G-I-L-L-L-A-E-I-I-L-C-L-V-I-L-I-C-F-S-A-G-T-S-G-Y-S-S-L-S-V-V-E-M-V-L-A-I-V-F-F-V-I-Y-M-C-D-L-H-T-R-A-P-F-I-N-W-P-W-S-D-F-F-R-T-L-I-A-A-I-L-Y-L-I-T-S-I-F-V-L-V-E-R-G-N-H-S-K-I-A-A-G-V-L-G-L-L-A-T-C-L-F-G-Y-D-A-Y-F-T-F-P-L-R-Q-Q-R-H-T-A-A-P-T-D-P-T-D-G-P-V


### FUNCTION Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca complex are a number of protein kinases and phosphatases ### SEQUENCE -M-T-D-A-L-S-E-E-Q-I-A-E-F-K-E-A-F-S-L-F-D-K-D-G-D-G-T-I-T-T-K-E-L-G-T-V-M-R-S-L-G-Q-N-P-T-E-A-E-L-Q-D-M-I-N-E-V-D-A-D-G-N-G-T-I-D-F-P-E-F-L-T-M-M-A-R-K-M-K-E-T-D-S-E-E-E-I-R-E-A-F-R-V-F-D-K-D-G-N-G-F-I-S-A-A-E-L-R-H-V-M-T-N-L-G-E-K-L-T-D-E-E-V-D-E-M-I-R-E-A-D-I-D-G-D-G-Q-V-N-Y-E-E-F-V-A-M-M-T-S-K


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-H-S-S-G-Y-T-R-P-L-P-K-P-S-R-P-I-F-I-R-P-I-G-C-D-V-C-Y-G-I-P-S-S-T-A-R-L-C-C-F-R-Y-G-D-C-C-H-R-G


### FUNCTION Antibacterial protein ### SEQUENCE -M-T-Y-A-I-L-I-I-V-S-L-L-L-I-S-D-R-I-S-N-V-V-D-K-Y-C-S-E-N-P-L-D-C-N-E-H-C-L-K-T-K-N-Q-I-G-I-C-H-G-A-N-G-N-E-K-C-S-C-M-E-S


### FUNCTION Inhibits potassium channels ### SEQUENCE -M-N-R-L-T-T-I-I-L-M-L-I-V-I-N-V-I-M-D-D-I-S-E-S-K-V-A-A-G-I-V-C-K-V-C-K-I-I-C-G-M-Q-G-K-K-V-N-I-C-K-A-P-I-K-C-K-C-K-K-G


### FUNCTION Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them ### SEQUENCE -M-I-N-H-N-I-I-S-F-K-K-F-E-A-I-F-E-Q-R-P-G-G-L-E-L-N-M-P-I-E-I-G-S-N-N-V-D-L-T-S-K-P-F-N-I-K-G-G-S-H-Y-K-V-K-I-G-Y-M-A-S-E-P-I-T-D-L-I-C-Q-I-H-T-F-R-K-S-T-P-Y-G-R-D-T-Q-K-V-G-D-I-C-A-N-T-N-D-L-E-F-D-F-P-K-F-G-W-E-Q-A-S-T-Q-S-S-S-M-G-D-Y-T-I-K-M-Y-F-K-G-N-G-N-Q-D-L-A-T-F-F-Y-S-F-N-V-A-P-D-W-E-N-A-L-P-I-N


### FUNCTION Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid ### SEQUENCE -M-A-S-Y-W-A-V-C-V-V-L-V-A-G-S-H-L-V-A-G-T-A-E-V-M-S-H-V-T-A-H-F-G-K-A-L-E-Q-C-R-E-E-S-G-L-S-T-A-V-L-E-E-F-Q-H-F-W-R-D-D-F-E-V-V-H-R-E-L-G-C-A-I-L-C-M-S-N-K-F-S-L-M-Q-D-D-A-R-M-H-H-E-N-M-H-D-Y-V-K-S-F-P-Q-G-E-V-L-S-A-K-M-V-E-L-I-H-N-C-E-K-P-Y-D-D-I-K-D-D-C-E-R-V-V-K-V-A-A-C-F-K-V-D-A-K-K-A-G-I-A-P-E-V-A-M-I-E-A-V-M-E-K-Y


### FUNCTION Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid ### SEQUENCE -M-A-T-V-S-K-W-R-M-L-V-L-T-L-C-L-T-G-V-W-Q-V-E-S-S-A-D-V-M-K-K-L-T-T-G-F-A-T-A-L-E-K-C-R-D-E-L-N-L-P-D-A-V-M-Q-D-F-F-N-F-W-R-E-D-Y-E-L-V-N-R-D-M-G-C-A-I-M-C-M-A-T-K-F-D-L-V-T-E-E-Q-K-L-H-H-G-N-A-H-E-F-A-K-S-H-G-A-D-D-S-M-A-K-Q-L-V-T-M-L-H-E-C-E-T-Q-T-A-S-I-S-D-D-C-G-R-T-L-E-I-A-K-C-F-R-T-K-I-H-G-L-K-W-A-P-S-M-E-T-I-L-E-E-V-M-T-E-V


### FUNCTION Involved in calcium binding and microtubule stabilization ### SEQUENCE -M-I-V-Y-K-D-M-I-T-E-D-E-M-F-T-D-S-H-C-P-R-V-V-A-D-F-F-Y-E-V-D-S-R-F-T-T-V-S-S-N-V-D-G-R-L-I-G-A-N-P-S-G-E-G-G-E-D-E-N-V-D-D-T-S-K-R-V-I-D-L-V-H-A-N-G-F-I-S-V-P-F-D-Q-K-S-Y-K-A-H-L-N-L-Y-L-K-T-I-I-E-R-L-Q-K-T-D-P-D-K-V-P-L-L-K-S-Q-V-N-K-Y-M-K-N-V-L-D-N-F-D-Q-Y-E-F-Y-M-G-P-P-S-N-P-D-A-M-I-V-L-M-N-F-R-E-D-G-M-T-P-Y-F-V-F-F-K-D-G-L-T


### FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase ### SEQUENCE -M-S-E-F-S-P-I-F-I-Y-L-V-M-S-L-L-V-S-L-I-L-L-G-L-P-F-L-F-A-S-N-S-S-T-Y-P-E-K-L-S-A-Y-E-C-G-F-D-P-F-G-D-A-R-S-R-F-D-I-R-F-Y-L-V-S-I-L-F-I-I-F-D-L-E-V-T-F-F-F-P-W-A-V-S-L-N-K-I-D-L-F-G-F-W-S-M-M-A-F-L-L-I-L-T-I-G-F-L-Y-E-W-K-R-G-A-L-D-W-E


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-G-Y-K-G-P-Y-T-R-P-I-L-R-P-Y-V-R-P-V-V-S-Y-N-V-C-T-L-S-C-R-G-I-T-T-T-Q-A-R-S-C-C-T-R-L-G-R-C-C-H-V-A-K-G-Y-S-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-G-A-Q-R-G-G-F-T-G-P-I-P-R-P-P-P-H-G-R-P-P-L-G-P-I-C-N-A-C-Y-R-L-S-F-S-D-V-R-I-C-C-N-F-L-G-K-C-C-H-L-V-K-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-G-Y-K-G-P-Y-T-R-P-I-L-R-P-Y-V-R-P-V-V-S-Y-N-A-C-T-L-S-C-R-G-I-T-T-T-Q-A-R-S-C-S-T-R-L-G-R-C-C-H-V-A-K-G-Y-S-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-G-C-K-G-P-Y-T-R-P-I-L-R-P-Y-V-R-P-V-V-S-Y-N-A-C-T-L-S-C-R-G-I-T-T-T-Q-A-R-S-C-C-T-R-L-G-R-C-C-H-V-A-K-G-Y-S-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-G-Y-K-G-P-Y-T-R-P-I-L-R-P-Y-V-R-P-V-V-S-Y-N-A-C-T-L-S-C-R-G-I-T-T-T-Q-A-R-S-C-C-T-R-L-G-R-C-C-H-V-A-K-G-Y-S-G


### FUNCTION Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA ### SEQUENCE -M-S-L-V-I-P-D-K-F-Q-H-I-L-R-I-M-N-T-N-I-D-G-K-R-K-V-M-F-A-M-T-A-I-K-G-V-G-R-R-Y-S-N-I-V-L-K-K-A-D-I-D-L-D-K-R-A-G-E-C-T-E-E-E-V-E-K-I-V-T-I-M-S-N-P-R-Q-Y-K-I-P-D-W-F-L-N-R-Q-K-D-I-V-D-G-K-Y-S-Q-L-T-S-S-N-L-D-S-K-L-R-E-D-L-E-R-L-K-K-I-R-A-H-R-G-M-R-H-Y-W-G-L-R-V-R-G-Q-H-T-K-T-T-G-R-R-G-R-T-V-G-V-S-K-K-K


### FUNCTION Component of the small ribosomal subunit The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell ### SEQUENCE -M-S-T-K-I-I-K-A-S-A-A-E-P-D-V-F-E-T-S-I-S-Q-A-L-V-E-L-E-T-N-S-D-L-K-A-Q-L-R-E-L-Y-I-T-K-A-K-E-I-E-L-H-N-K-K-S-I-I-I-Y-V-P-M-P-K-L-K-A-F-Q-K-I-Q-I-R-L-V-R-E-L-E-K-K-F-S-G-K-H-V-V-F-I-G-D-R-K-I-L-P-K-P-S-H-K-T-R-V-A-N-K-Q-K-R-P-R-S-R-T-L-T-S-V-Y-D-A-I-L-E-D-L-V-F-P-A-E-I-V-G-K-R-I-R-I-K-L-D-G-S-Q-L-I-K-V-H-L-D-K-N-Q-Q-T-T-I-E-H-K-V-D-T-F-Q-S-V-Y-K-K-L-T-G-R-E-V-T-F-E-F-P-E-P-Y-L


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-T-K-G-T-S-S-F-G-K-R-R-N-K-T-H-T-L-C-R-R-C-G-R-S-S-Y-H-I-Q-K-S-K-C-A-Q-C-G-Y-P-A-A-K-L-R-S-Y-H-W-S-V-K-A-K-R-R-K-T-T-G-T-G-R-M-R-H-L-K-I-V-R-R-R-F-R-N-G-F-K-E-G-K-P-T-P-K-K-A-V-A-S-S


### FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell The small ribosomal subunit , which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel ### SEQUENCE -M-A-R-V-P-P-P-A-L-K-K-D-K-K-E-K-K-P-P-K-D-N-S-K-N-V-M-R-N-L-H-I-R-K-L-C-L-N-I-C-V-G-E-S-G-D-R-L-T-R-A-A-K-V-L-E-Q-L-T-G-Q-Q-P-V-F-S-K-A-R-Y-T-V-R-S-F-G-I-R-R-N-E-K-I-A-V-H-C-T-V-R-G-A-K-A-E-E-I-L-E-R-G-L-K-V-R-E-Y-E-L-R-R-D-N-F-S-A-T-G-N-F-G-F-G-I-Q-E-H-I-D-L-G-I-K-Y-D-P-S-I-G-I-Y-G-L-D-F-Y-V-V-L-G-P-T-R-I-Q-C-T-T-Q-K-T-Q-D-W-Q-G-W-I-P-P-I-V-L-T-K-E-D-A-M-K-W-F-Q-Q-K-Y-D-G-I-I-L-N-S-K-K


### FUNCTION Necessary for protein translocation in the endoplasmic reticulum and multi-pass membrane protein biogenesis ### SEQUENCE -M-D-Q-L-V-Q-F-V-E-P-A-R-Q-F-A-K-D-S-Y-R-L-V-K-R-C-T-K-P-D-R-K-E-F-Q-K-I-A-M-A-T-A-I-G-F-A-I-M-G-F-I-G-F-F-V-K-L-I-H-I-P-I-N-N-I-I-V-G-S


### FUNCTION May have a role in the cell cycle ### SEQUENCE -M-A-N-H-N-S-S-R-H-T-I-I-L-L-Q-N-S-P-S-R-A-T-R-T-F-M-D-Y-D-S-I-G-Q-A-M-D-G-I-C-G-L-Y-E-R-K-L-K-E-I-N-P-S-L-R-N-I-S-Y-D-I-A-D-L-Y-N-F-I-D-G-L-A-D-L-S-A-L-V-Y-D-H-S-I-S-A-Y-L-P-Y-D-R-Q-W-I-K-Q-K-A-F-H-H-L-K-R-I-A-N-G-G-R


### FUNCTION Metallothioneins have a high content of cysteine residues that bind various heavy metals ### SEQUENCE -E-A-S-G-E-T-F-V-A-E-N-D-A-C-K-C-G-S-D-C-K-C-N-P-C-T-C-K


### FUNCTION Metallothioneins have a high content of cysteine residues that bind various heavy metals ### SEQUENCE -M-S-D-T-C-G-N-C-D-C-A-D-K-T-Q-C-V-K-K-G-S-S-Y-T-A-D-I-I-E-T-E-K-S-I-M-T-V-V-M-D-A-P-A-A-E-N-D-G-K-C-K-C-G-P-S-C-S-C-T-N-C-T-C-G-H


### FUNCTION Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria ### SEQUENCE -M-N-F-A-K-V-F-V-L-V-A-M-A-V-L-L-L-V-G-Q-S-E-A-G-G-L-K-K-L-G-K-K-L-E-G-A-G-K-R-V-F-N-A-A-E-K-A-L-P-V-V-A-G-A-K-A-L-G-K


### FUNCTION Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria ### SEQUENCE -M-N-F-N-K-L-F-A-I-V-L-L-A-A-L-V-L-L-G-Q-T-E-A-G-G-L-K-K-F-G-K-K-L-E-G-V-G-K-R-V-F-K-A-S-E-K-A-L-P-V-A-V-G-I-K-A-L-G-K


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Y-S-S-G-Y-T-R-P-L-P-K-P-S-R-P-I-F-I-R-P-I-G-C-D-V-C-Y-G-I-P-S-S-T-A-R-L-C-C-F-R-Y-G-D-C-C-H-R-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-E-A-Y-R-G-G-Y-T-G-P-I-P-R-P-P-P-I-G-R-P-P-L-R-P-V-C-N-A-C-Y-R-L-S-V-S-D-A-R-N-C-C-I-K-F-G-S-C-C-H-L-V-K-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-V-Y-K-G-G-Y-T-R-P-I-P-R-P-P-P-F-V-R-P-L-P-G-G-P-I-G-P-Y-N-G-R-P-V-S-C-R-G-I-S-F-S-Q-A-R-S-C-C-S-R-L-G-R-C-C-H-V-G-K-G-Y-S-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-V-Y-K-G-G-Y-T-R-P-I-P-R-P-P-P-F-V-R-P-L-P-G-G-P-I-G-P-Y-N-G-C-P-I-S-C-R-G-I-S-F-S-Q-A-R-S-Y-C-S-R-L-G-R-C-C-H-V-G-K-G-Y-S-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-V-Y-K-G-G-Y-T-R-P-I-P-R-P-P-P-F-V-R-P-L-P-G-G-P-I-S-P-Y-N-G-C-P-V-S-C-R-G-I-S-F-S-Q-A-R-S-C-C-S-R-L-G-R-C-C-H-V-G-K-G-Y-S-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-A-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-V-Y-K-G-G-Y-T-R-P-I-P-R-P-P-P-F-V-R-P-L-P-G-G-P-I-G-P-Y-N-G-C-P-I-S-C-R-G-I-S-F-S-Q-A-R-S-C-C-S-R-L-G-R-C-C-H-V-G-K-G-Y-S-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-P-F-A-L-V-C-H-G-Q-V-Y-K-G-G-Y-T-R-P-I-P-R-P-P-P-F-V-R-P-L-P-G-G-P-I-G-P-Y-N-G-C-P-V-S-C-R-G-I-S-F-S-Q-A-R-S-C-C-S-R-L-G-R-C-C-H-V-G-K-G-Y-S-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-V-Y-K-G-G-Y-T-R-P-I-P-R-P-P-P-F-V-R-P-L-P-G-G-P-I-G-P-Y-N-G-C-P-I-S-C-R-G-I-S-F-S-Q-A-R-S-C-C-S-R-L-G-R-C-C-H-V-G-K-G-Y-S-G


### FUNCTION Antibacterial and antifungal activity Presents chitin-binding activity ### SEQUENCE -M-R-L-V-V-C-L-V-F-L-A-S-F-A-L-V-C-Q-G-Q-V-Y-K-G-G-Y-T-R-P-V-P-R-P-P-F-V-R-P-L-P-G-G-P-I-G-P-Y-N-G-C-P-V-S-C-R-G-I-S-F-S-Q-A-R-S-C-C-S-R-L-G-R-C-C-H-V-G-K-G-Y-S-G


### FUNCTION Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide The H form is known to activate a number of cytosolic enzymes ### SEQUENCE -M-A-E-E-A-Q-V-I-A-C-H-T-V-Q-E-W-N-E-K-F-Q-K-A-K-D-S-G-K-L-I-V-I-D-F-T-A-S-W-C-G-P-C-R-V-I-T-P-Y-V-S-E-L-A-K-K-F-P-H-V-A-F-F-K-V-D-V-D-D-L-K-D-V-A-E-E-Y-K-V-E-A-M-P-S-F-V-I-L-K-E-G-Q-E-V-E-R-I-V-G-A-R-K-D-E-L-L-H-K-I-A-V-H-A-P-I-T-A


### FUNCTION A1b binds to basic 7S globulin  and stimulates its phosphorylation activity ### SEQUENCE -I-P-P-S-R-S-S-D-C-R-C-V-P-I-T-L-I-V-G-F-C-I-H-P-T-G-L-S-S-V-A-K-M-I-D-E-H-P-N-L-C-Q-S-D-D-E-C-M-K-K-G-S-G-N-F-C-A-R-Y-P-N-N-Y-I-D-Y-G-W-C-F-G-S-D-S-E-A-L-K-G-F-L


### FUNCTION Seems to function only as a co-chaperone, along with cpn60, and in certain cases is essential for the discharge of biologically active proteins from cpn60 ### SEQUENCE -M-M-K-R-L-I-P-T-F-N-R-I-L-V-Q-G-V-I-Q-P-A-K-T-E-S-G-I-L-L-P-E-K-A-S-K-L-N-S-G-K-V-I-A-V-G-P-G-S-R-D-K-D-G-K-L-I-P-V-S-V-K-E-G-D-T-V-L-L-P-E-Y-G-G-T-Q-V-K-L-G-E-K-E-Y-H-L-F-R-D-E-D-V-L-G-T-L-H-E-D


### FUNCTION RuBisCO catalyzes two reactions the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Both reactions occur simultaneously and in competition at the same active site Although the small subunit is not catalytic it is essential for maximal activity ### SEQUENCE -M-A-C-S-M-I-S-S-A-T-V-A-A-V-S-R-A-S-P-A-Q-S-S-M-V-A-P-F-T-C-L-K-S-T-S-A-F-P-V-T-Q-K-T-N-N-D-I-T-S-I-A-S-N-G-G-R-V-Q-C-M-Q-V-W-P-P-L-G-L-K-K-F-E-T-L-S-Y-L-P-P-L-S-S-E-Q-L-A-K-E-V-D-Y-L-L-R-K-N-L-I-P-C-L-E-F-E-L-E-H-G-F-V-Y-R-E-H-N-R-S-P-G-Y-Y-D-G-R-Y-W-T-M-W-K-L-P-M-F-G-C-N-D-S-S-Q-V-L-K-E-L-E-E-C-K-K-A-Y-P-S-A-F-I-R-I-I-G-F-D-N-K-R-Q-V-Q-I-I-S-F-I-A-Y-K-P-P-G-V


### FUNCTION May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil Probably interacts with both lipid and phospholipid moieties of lipid bodies May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth ### SEQUENCE -M-A-D-H-H-R-D-R-G-V-L-G-G-G-A-L-G-E-R-G-S-H-G-G-Y-G-Y-T-G-D-H-G-G-Y-G-G-D-D-E-Q-H-Q-Q-K-Q-P-V-M-M-C-A-L-K-A-A-T-A-A-T-A-G-G-S-M-L-V-L-S-G-L-I-L-A-G-T-V-I-A-L-T-V-A-T-P-V-L-V-I-F-S-P-V-L-V-P-A-A-I-S-M-A-L-M-S-A-G-F-V-T-S-G-G-L-G-V-A-A-V-S-V-F-S-W-M-Y-K-Y-L-A-G-K-H-P-P-G-A-D-Q-L-D-H-A-K-A-R-L-A-S-K-A-R-D-I-K-D-A-A-Q-I-R-V-E-Q-A-Q-G-A


### FUNCTION Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid Involved in virus secondary attachment to host cell after initial attachment by the fiber protein, and in endocytosis of virions As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome ### SEQUENCE -I-R-N-A-T-L-L-V-T-P-D-V-T-C-G-M-E-Q-V-Y-W-S-I-P-D-M-Y-V-E-P-V-T-F-K-A-S-Q-N-V-S-N-Y-P-V-I-G-V-E-L-M-P-Q-R-P-R-S-F-Y-N-A-Q-A-V-Y-S-Q-M-I-Q-E-N-T-N-Q-T-M-V-F-N-R-F-P-D-N-Q-I-F-L-R-P-P-E-S-T-I-T-S-I-S-E-N-V-P-T-Q-T-D-H-G-T-L-P-I-R-N-S-V-S-G-V-Q-R-V-T-L-T-D-A-R-R-R-A-S-P-Y-V-Y-K-S-I-A-V-A-Q-P-K-V-L-S-S-R-T-F


### FUNCTION The role of the precursor might be to condense the viral prochromatin for encapsidation by virtue of the two basic domains ### SEQUENCE -M-T-G-V-P-R-V-T-Y-R-V-R-V-P-V-R-T-R-V-L-R-P-R-R-H-G-R-L-V-R-R-V-A-R-R-K-S-M-R-G-G-F-L-P-F-L-V-P-L-I-A-A-A-I-G-A-A-P-G-I-A-S-V-A-L-Q-A-S-R-R


### FUNCTION Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication E1A protein has both transforming and trans-activating activities Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF ubiquitin ligase complex, and may be linked to unregulated host cell proliferation The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif ### SEQUENCE -M-K-L-T-L-E-P-A-P-R-C-L-H-E-Y-V-S-Q-L-L-E-D-W-Q-P-E-C-L-S-C-E-Y-S-H-G-G-S-S-P-P-S-L-H-D-L-F-D-L-E-L-E-N-S-R-S-P-S-P-L-L-C-D-W-C-A-E-A-D-S-E-S-T-I-S-T-E-T-D-V-G-F-T-L-N-T-P-P-V-S-P-L-P-S-Y-S-T-S-P-A-S-I-P-E-D-M-L-L-C-L-E-E-M-P-T-F-D-D-G-D-E-V-R-S-A-T-T-S-F-E-H-W-E-N-N-F-D-P-N-V-G-S-F-F-G-C-L-R-C-A-Y-Y-Q-E-Q-G-E-N-S-I-C-G-L-C-Y-L-K-A-L-A-E-G-K-I-F


### FUNCTION Increases viral DNA accumulation Enhances infectivity and symptom expression ### SEQUENCE -M-D-S-R-T-G-E-S-I-T-V-A-Q-A-E-N-S-V-F-I-W-E-V-P-N-P-L-Y-F-R-I-Q-R-V-E-D-P-L-Y-T-R-T-R-I-Y-H-I-Q-V-R-F-N-H-N-L-R-K-A-L-D-L-R-K-A-Y-F-N-F-Q-V-W-T-T-S-M-R-A-S-G-P-T-Y-L-S-R-F-K-C-L-V-M-S-H-L-D-N-L-G-V-I-G-I-N-H-V-I-R-A-V-R-F-A-T-D-R-S-Y-V-T-H-V-H-E-N-H-V-I-N-F-K-I-Y


### FUNCTION Pathogenicity determinant , a mechanism of plant viral defense that limits the accumulation of viral RNAs ### SEQUENCE -M-K-L-F-R-C-F-K-P-C-R-G-Q-S-S-N-P-H-T-S-E-S-Q-E-R-N-I-Q-T-G-S-P-I-Y-T-V-S-S-N-Y-Q-E-S-R-T-S-R-M-L-D-F-S-T-S-L-T-P-E-G-L-P-I-F-T-Q-T-F-R-Q-P-K-T-P-M-P-S-R-I-T-S-P-K-M-V-I-I-V-N-P-G-S-T-R-C-L-G-V-Q-R-Q-I-K-T-T-S-T-T-T-P-S-M-R-D-V-W-K-R-L-S-Q-L


### FUNCTION Plays an important role in the elongation step of protein synthesis ### SEQUENCE -M-K-Y-V-A-A-Y-L-M-T-V-L-G-G-N-E-A-P-T-A-A-D-V-S-R-V-L-E-P-V-G-A-E-V-N-P-E-V-L-K-T-L-I-D-A-M-Q-G-K-A-A-H-E-V-I-S-A-G-L-E-K-L-Q-K-V-P-C-G-G-G-A-A-A-A-A-P-A-A-A-A-A-A-G-G-G-D-S-S-S-A-A-K-E-T-K-K-E-E-P-E-E-E-E-E-D-G-D-M-G-L-S-L-F-D


### FUNCTION May be involved in transcriptional regulation ### SEQUENCE -M-E-K-P-Y-N-K-N-E-G-N-L-E-N-E-G-K-P-E-D-E-V-E-P-D-D-E-G-K-S-D-E-E-E-K-P-D-V-E-G-K-T-E-C-E-G-K-R-E-D-E-G-E-P-G-D-E-G-Q-L-E-D-E-G-S-Q-E-K-Q-G-R-S-E-G-E-G-K-P-Q-G-E-G-K-P-A-S-Q-A-K-P-E-S-Q-P-R-A-A-E-K-R-P-A-E-D-Y-V-P-R-K-A-K-R-K-T-D-R-G-T-D-D-S-P-K-D-S-Q-E-D-L-Q-E-R-H-L-S-S-E-E-M-M-R-E-C-G-D-V-S-R-A-Q-E-E-L-R-K-K-Q-K-M-G-G-F-H-W-M-Q-R-D-V-Q-D-P-F-A-P-R-G-Q-R-G-V-R-G-V-R-G-G-G-R-G-Q-R-G-L-H-D-I-P-Y-L


### FUNCTION Binds and inhibits cysteine proteinases Inhibits most strongly papain and cathepsin L, more weakly bromelain and cathepsin B while it is completely ineffective against cathepsin H ### SEQUENCE -M-A-S-L-E-D-G-I-Y-R-L-R-A-V-T-T-H-N-P-D-P-G-V-G-G-E-Y-A-T-V-E-G-A-R-Q-P-V-K-A-E-P-S-T-P-P-F-F-E-R-Q-I-W-Q-V-T-R-N-S-D-G-Q-S-T-I-K-Y-Q-G-L-N-T-P-F-E-Y-G-F-S-Y-D-Q-L-E-Q-N-A-P-V-I-A-G-D-P-K-E-Y-I-L-Q-L-V-P-S-T-T-D-V-Y-I-I-R-A-P-I-Q-R-V-G-V-D-V-E-V-G-V-Q-G-N-N-L-V-Y-K-F-F-P-V-D-G-S-G-G-D-R-P-A-W-R-F-T-R-E


### FUNCTION Subunit of the oligosaccharyl transferase  All subunits are required for a maximal enzyme activity ### SEQUENCE -M-T-D-V-Q-L-Q-N-I-V-T-T-F-G-I-S-M-M-L-L-I-I-L-Y-H-Y-L-S-R-P-Q-A


### FUNCTION Facilitates protein transport into the nucleus Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import ### SEQUENCE -M-A-D-F-Q-S-I-A-Q-Q-F-V-T-F-Y-Y-Q-T-F-D-G-N-R-A-G-L-A-P-L-Y-R-D-H-S-M-L-T-F-E-T-S-A-I-Q-G-V-A-G-I-I-E-K-L-T-S-L-P-F-Q-K-V-Q-H-Q-V-S-T-L-D-A-Q-P-S-G-E-H-G-G-I-L-V-L-V-T-G-A-L-L-V-D-E-E-K-N-P-M-N-Y-T-Q-T-F-Q-L-M-P-D-G-A-G-S-Y-F-V-L-N-D-V-F-R-L-I-Y-N-A


### FUNCTION Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner It has the ability to bind G- and F-actin in a 11 ratio of cofilin to actin Binding to F-actin is regulated by tropomyosin It is the major component of intranuclear and cytoplasmic actin rods Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments Involved in the maintenance of the contractile ring once formed In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton ### SEQUENCE -M-S-R-S-G-V-A-V-S-D-E-A-L-K-A-F-N-D-L-K-L-G-K-K-F-K-S-I-I-Y-K-L-N-D-A-K-T-E-I-V-V-D-S-T-S-T-E-D-A-Y-D-A-F-V-E-D-L-P-E-N-D-C-R-Y-A-V-Y-D-F-E-Y-E-V-G-Q-G-D-G-K-R-N-K-I-V-F-Y-Q-W-S-P-D-T-A-S-V-R-A-K-M-V-Y-A-S-S-K-D-A-L-R-R-A-L-N-G-I-G-T-E-I-Q-G-T-D-F-S-E-V-A-Y-E-S-V-L-E-K-I-S-R-T-T-G-L-H


### FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell The small ribosomal subunit , which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel ### SEQUENCE -M-T-R-T-S-V-L-A-D-A-L-N-A-I-N-N-A-E-K-T-G-K-R-Q-V-L-I-R-P-S-S-K-V-I-I-K-F-L-T-V-M-Q-K-H-G-Y-I-G-E-F-E-Y-I-D-D-H-R-S-G-K-I-V-V-Q-L-N-G-R-L-N-K-C-G-V-I-Q-P-R-F-N-V-K-I-N-D-I-E-R-W-T-D-N-L-L-P-A-R-Q-F-G-Y-V-I-L-T-T-S-A-G-I-M-D-H-E-E-A-R-R-K-H-V-S-G-K-I-L-G-F-V-Y


### FUNCTION Contacts the emerging nascent chain on the ribosome ### SEQUENCE -M-K-P-K-P-S-Q-F-K-N-L-E-R-M-L-G-L-K-T-E-Q-L-D-A-V-K-V-T-I-E-L-K-D-K-I-L-I-I-E-N-P-T-V-I-K-M-I-A-Q-G-Q-E-I-Y-S-V-I-G-E-A-K-E-A-Q-K-E-E-P-K-V-E-I-K-D-E-D-V-K-F-V-M-E-Q-T-G-K-G-E-Q-E-V-K-E-A-L-Q-K-A-N-G-D-I-A-K-A-I-L-L-L-T-G-Q-E-T


### FUNCTION Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP May hydrolyze nucleoside diphosphates with lower efficiency ### SEQUENCE -M-Q-T-R-L-R-V-Y-I-T-G-E-P-G-V-G-K-T-T-I-F-L-K-V-I-D-K-L-K-S-Q-G-Y-S-I-S-G-F-Y-C-P-E-V-R-E-K-G-Q-R-I-G-F-K-I-K-S-L-D-N-E-V-E-D-W-L-A-S-I-Y-A-K-S-S-I-K-I-G-K-Y-Y-I-T-I-N-E-D-I-I-N-K-I-K-E-K-I-S-K-S-E-I-I-G-I-D-E-I-G-P-M-E-L-S-V-P-K-L-K-E-I-I-D-Y-V-L-N-E-K-P-I-V-V-A-V-V-H-R-K-I-S-F-K-D-G-K-T-F-V-V-T-Y-E-N-R-N-R-L-D-N-E-I-F-N-Y-I-I-S-S-I-Q


### FUNCTION Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA In the 70S ribosome it contacts the 23S rRNA , connecting the 2 subunits ### SEQUENCE -M-S-Q-Q-Q-Q-F-K-Y-I-V-R-L-F-G-Q-D-V-D-G-T-M-K-V-P-Y-A-L-A-M-V-K-G-I-G-Y-N-T-A-R-A-I-V-F-K-L-G-L-D-K-D-R-R-L-G-E-L-S-D-E-D-I-K-K-I-E-N-Y-L-T-D-K-K-I-L-E-V-P-N-W-M-Y-N-R-R-K-D-Y-E-S-G-I-D-M-H-L-V-T-S-D-L-I-F-Y-V-R-N-D-I-E-R-E-K-K-I-K-S-W-R-G-V-R-H-S-L-G-L-K-V-R-G-Q-R-T-R-T-T-G-R-T-G-V-T-V-G-V-R-R-S-K-A-A-Q-A-A-Q-Q-Q-Q-K-A-Q-A-S-S-G-G-E-K-K-Q-G


### FUNCTION Located on the platform of the 30S subunit ### SEQUENCE -M-S-S-R-R-E-I-R-W-G-I-A-R-V-Y-A-S-Q-N-N-T-L-I-T-I-T-D-I-T-G-A-E-I-I-S-R-A-S-G-G-M-V-V-K-A-D-R-E-K-P-S-P-Y-A-A-M-L-A-A-N-K-A-A-T-E-A-F-D-K-G-I-S-A-I-H-I-K-V-R-A-Q-G-G-Y-G-S-K-T-P-G-P-G-A-Q-P-A-I-R-A-L-A-R-A-G-F-I-I-G-R-I-E-D-V-T-P-I-P-H-D-S-I-R-R-P-G-G-R-R-G-R-R-V


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-S-E-Q-L-V-V-V-N-A-E-N-Q-I-L-G-R-M-A-T-H-I-A-K-L-L-I-Q-G-K-R-V-V-V-V-N-A-E-K-A-I-I-S-G-P-R-A-R-V-V-R-G-Y-S-L-I-F-S-V-R-K-F-Q-N-P-E-K-N-T-I-K-R-P-R-T-P-I-N-I-V-K-R-T-V-R-G-M-L-P-K-N-K-S-G-K-M-M-F-K-N-L-I-V-F-I-G-I-P-A-E-Y-K-D-K-Q-M-I-R-F-E-D-A-D-V-K-R-L-K-G-K-Y-I-T-V-G-E-L-S-K-L-L-G-G-F-S-Q


### FUNCTION The glycine cleavage system catalyzes the degradation of glycine The H protein shuttles the methylamine group of glycine from the P protein to the T protein ### SEQUENCE -M-A-N-V-S-N-C-E-I-P-E-N-L-L-Y-F-I-E-G-K-N-T-V-W-A-K-Q-E-A-P-D-V-I-V-V-G-I-T-D-I-A-Q-T-M-A-G-K-V-V-K-V-R-L-K-K-K-G-T-K-V-E-R-G-K-P-V-A-T-M-E-S-G-K-W-A-G-P-V-P-A-P-A-S-G-E-I-I-D-V-N-P-D-V-E-K-N-P-V-L-V-N-Q-D-P-Y-G-K-G-W-L-V-K-M-K-V-N-N-P-E-E-L-K-Q-L-V-T-G-S-A-A-V-S-K-L-T-E-L-I-N-S-E-K-L-Q-C-K-R-L


### FUNCTION The glycine cleavage system catalyzes the degradation of glycine The H protein shuttles the methylamine group of glycine from the P protein to the T protein ### SEQUENCE -M-Q-V-E-G-F-E-F-P-D-E-L-Y-Y-Y-P-E-E-H-V-W-V-K-I-E-G-D-M-V-T-V-G-I-T-S-L-G-Q-Y-M-A-G-K-I-F-Q-V-T-T-K-N-K-G-E-K-V-T-P-K-S-V-I-F-T-L-E-S-A-K-W-I-G-K-F-R-L-P-V-E-G-E-I-V-D-I-N-D-E-V-V-K-N-P-T-L-I-N-E-K-P-Y-D-A-W-I-V-K-I-K-G-D-I-K-K-E-K-L-L-P-V-S-E-A-V-K-I-F-E-N-D-A-K-R-V-I-R


### FUNCTION Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7 ### SEQUENCE -M-R-L-P-G-I-P-D-E-E-F-I-R-V-E-K-I-P-M-T-K-E-E-I-R-V-L-A-L-S-K-A-R-L-F-D-G-A-K-F-I-D-I-G-S-G-T-G-S-V-T-V-E-A-G-L-V-V-G-E-K-G-K-V-W-A-I-E-K-D-K-D-A-V-E-L-T-K-K-N-V-E-K-F-K-L-N-N-V-V-I-I-E-G-E-A-P-E-A-L-D-H-V-D-S-E-V-D-A-I-F-I-G-G-T-E-R-L-E-E-I-L-L-S-S-D-K-K-L-K-N-G-G-R-I-V-I-D-A-I-L-L-E-T-V-N-K-A-L-S-T-L-N-Q-M-G-Y-K-T-D-V-I-E-V-I-I-A-K-G-M-K-T-S-K-G-Y-A-M-I-S-R-N-P-I-F-I-V-Y-G-E-K-P


### FUNCTION Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate ### SEQUENCE -M-D-F-I-K-S-L-V-E-N-K-L-L-L-I-G-N-F-V-L-T-S-G-K-I-S-P-Y-Y-L-D-L-R-R-L-S-N-Y-Y-E-I-F-S-D-T-V-N-K-A-I-D-K-I-K-N-I-D-F-D-M-I-I-G-I-A-T-G-G-I-P-F-A-S-F-I-S-C-R-M-G-K-P-L-G-Y-I-R-M-E-K-K-G-Y-G-T-D-K-I-L-E-A-D-V-S-G-R-K-I-L-L-V-D-D-V-A-T-T-G-G-S-L-S-K-A-V-E-I-I-N-S-E-G-G-R-V-V-A-S-L-V-I-V-D-R-E-E-G-A-E-K-K-L-G-E-Y-G-V-K-L-I-S-V-Y-K-I-R-E-I-L-E-Y-L-L-N-S-S-L-I-S-D-N-D-K-N-N-I-K-E-Y-L-V-K-N-I-E


### FUNCTION Involved in allosteric regulation of aspartate carbamoyltransferase ### SEQUENCE -M-E-T-V-N-K-K-E-L-I-V-S-K-I-K-N-G-T-V-I-D-H-I-P-A-G-R-A-L-A-V-L-R-I-L-K-I-A-E-G-Y-R-I-A-L-V-M-N-V-E-S-K-K-M-G-K-K-D-I-V-K-I-E-N-K-E-V-D-E-K-E-A-N-L-I-T-L-I-A-P-T-A-T-I-N-I-I-R-D-Y-E-V-V-E-K-K-K-L-K-I-P-D-I-V-K-G-L-L-K-C-T-N-L-M-C-I-T-N-N-D-V-E-A-I-P-G-F-K-K-I-S-E-K-P-L-K-M-K-C-V-Y-C-D-T-V-I-D-E-N-E-I-L-K-Q-I-L-G-S-K-S


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-S-N-E-E-N-Q-Q-K-V-V-V-S-L-E-D-L-L-A-Q-A-D-A-L-K-K-Y-I-D-Y-L-Q-K-T-Y-A-E-L-Q-D-N-I-M-S-I-D-S-S-L-Q-A-L-K-E-L-Q-N-S-Q-E-L-L-M-V-G-D-K-R-G-N-V-I-F-K-V-Q-G-I-D-K-A-K-V-L-V-H-L-G-L-E-Y-Y-A-E-V-D-P-D-F-A-T-K-V-L-N-D-K-K-S-E-L-S-N-V-L-S-N-V-E-K-E-L-A-K-S-L-E-A-Y-K-E-I-A-D-I-L-N-Q-A-Q-Q-Q-L-Q-A-Q-Q-N-K-G-G


### FUNCTION Essential subunit of the Sec protein translocation channel SecYEG Clamps together the 2 halves of SecY May contact the channel plug during translocation ### SEQUENCE -M-S-L-S-Q-R-L-K-N-L-R-E-D-W-K-R-I-I-S-V-A-K-K-P-E-K-D-T-L-N-Q-S-I-K-L-T-L-L-V-M-A-I-V-G-I-I-A-Y-I-I-Q-L-T-V-A-L-L-L-H


### FUNCTION Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors ### SEQUENCE -M-P-T-K-S-I-K-I-V-V-E-G-G-N-V-K-P-G-P-P-L-A-P-T-L-S-Q-L-G-L-N-V-G-E-V-V-K-K-I-N-D-A-T-S-Q-F-K-G-M-S-V-P-V-T-L-E-V-D-T-D-T-K-K-Y-E-I-K-V-G-I-P-T-T-T-S-L-L-L-K-F-A-N-A-S-E-P-S-G-D-P-A-H-K-K-V-G-D-I-K-F-E-D-I-I-Q-V-A-I-M-K-K-P-Q-I-T-A-K-T-L-K-A-A-V-K-S-I-L-G-T-A-H-S-I-G-L-T-V-D-K-K-S-P-K-E-L-V-K-A-V-D-E-G-K-Y-D-D-L-L-A-K-Y-E-Q-K-W-N-E-A-E-G


### FUNCTION Functions by promoting the formation of the first peptide bond ### SEQUENCE -M-S-I-Q-Y-T-T-V-G-D-L-K-V-G-N-Y-V-V-I-D-G-E-P-C-R-V-V-E-I-S-K-A-K-T-G-K-H-G-S-A-K-A-N-I-V-A-I-G-L-F-T-G-Q-K-R-T-L-M-A-P-V-D-Q-Q-V-E-V-P-I-I-E-K-H-I-G-Q-I-L-A-D-K-G-D-T-I-T-I-M-D-M-E-N-Y-E-T-F-D-I-E-K-P-T-D-A-D-I-V-D-K-I-R-P-G-A-E-V-E-Y-W-E-I-M-G-R-K-K-I-V-R-V-K


### FUNCTION Binds double-stranded DNA tightly but without sequence specificity It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture However, it does not significantly compact DNA Binds rRNA and mRNA in vivo May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes ### SEQUENCE -M-T-V-K-K-P-N-E-I-L-I-S-R-T-K-R-V-E-D-Y-V-L-D-V-I-V-M-F-N-Q-G-Y-D-E-V-E-L-K-G-V-G-N-S-I-Y-K-A-V-E-V-Y-N-Q-L-K-D-R-L-G-D-G-I-I-L-E-K-A-D-I-G-S-E-V-K-D-R-R-R-I-S-Y-I-S-I-K-L-K-R-V-Y


### FUNCTION Binds double-stranded DNA tightly but without sequence specificity It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture However, it does not significantly compact DNA Binds rRNA and mRNA in vivo May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes ### SEQUENCE -M-S-S-T-A-T-P-T-P-S-N-V-V-L-V-G-K-K-P-V-M-N-Y-V-L-A-A-L-T-L-L-N-Q-G-V-S-E-I-I-I-K-A-R-G-R-A-I-S-K-A-V-D-T-V-E-I-V-R-N-R-F-L-P-D-K-I-E-V-K-E-I-R-I-G-S-Q-V-V-T-S-Q-D-G-R-Q-S-R-V-S-T-I-E-I-A-I-R-K-K-A


### FUNCTION Allows the formation of correctly charged Asn-tRNA ### SEQUENCE -M-K-I-E-V-N-N-E-L-I-S-R-L-Q-N-L-A-L-V-E-L-N-D-R-E-K-E-R-I-K-R-D-I-K-N-I-L-D-F-F-D-Q-I-N-K-L-D-L-S-N-V-E-P-L-F-H-P-I-S-T-G-K-L-R-K-D-E-I-I-K-P-L-S-R-D-E-A-L-S-N-V-K-R-K-E-D-G-F-I-V-G-P-A-T-Y-G-E


### FUNCTION General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation ### SEQUENCE -M-T-N-I-P-E-I-P-Y-K-A-V-V-N-I-E-N-I-V-A-T-V-T-L-D-Q-N-L-D-L-Y-A-M-E-R-S-V-P-N-V-E-Y-D-P-D-Q-F-P-G-L-I-F-R-L-E-A-P-K-V-T-S-L-I-F-K-S-G-K-M-V-V-T-G-A-K-S-T-D-E-L-I-K-A-V-K-R-I-I-K-T-L-K-R-Y-G-M-N-L-T-G-K-P-K-I-Q-I-Q-N-I-V-A-S-A-N-L-H-V-I-V-N-L-D-K-A-A-F-L-L-E-N-N-M-Y-E-P-E-Q-F-P-G-L-I-Y-R-M-E-D-P-R-V-V-L-L-I-F-S-S-G-K-M-V-I-T-G-A-K-R-E-E-E-V-H-K-A-V-K-K-I-F-D-K-L-V-E-L-D-C-V-K-P-F-E-E-E-E-L-E-F


### FUNCTION DNA-dependent RNA polymerase  catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates ### SEQUENCE -M-S-I-N-K-I-F-E-E-S-W-K-N-R-L-T-K-Y-E-I-A-R-I-I-S-A-R-A-L-Q-L-A-M-G-A-S-P-L-I-D-T-N-N-L-P-F-N-D-V-I-S-I-A-E-E-E-L-K-R-G-V-L-P-I-T-V-R-R-V-Y-P-N-G-K-I-E-L-V-S-V-K-K-V-E-F-K


### FUNCTION The glycine cleavage system catalyzes the degradation of glycine The H protein shuttles the methylamine group of glycine from the P protein to the T protein ### SEQUENCE -M-S-E-I-I-V-G-G-K-Y-K-V-L-K-D-R-Y-Y-S-E-T-D-E-W-I-L-V-K-E-N-I-A-I-V-G-I-T-D-Y-A-Q-K-K-L-R-D-I-V-G-V-E-L-P-E-I-D-K-E-V-K-A-N-D-P-V-A-V-V-E-S-V-K-A-A-A-D-I-Y-S-P-L-S-G-K-V-I-E-T-N-Q-K-L-T-E-S-P-E-L-I-N-K-D-P-Y-G-E-G-W-I-F-K-L-E-I-S-D-R-N-E-I-E-K-L-L-S-P-E-K-Y-S-E-L-I-K-Q-R-E-G-L


### FUNCTION Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide ### SEQUENCE -M-I-D-K-K-E-L-R-E-I-S-L-K-K-K-R-E-K-R-L-T-W-E-E-I-G-K-Y-L-G-R-D-K-V-Y-A-A-M-L-L-Y-G-Y-A-Q-A-T-E-E-E-A-D-K-I-I-T-L-L-D-L-P-K-E-L-K-P-A-F-L-D-A-P-M-R-T-P-A-Q-P-W-P-P-T-D-P-F-I-Y-R-L-Y-E-G-V-L-L-Y-G-P-V-I-K-D-V-A-H-E-L-F-G-D-G-I-M-S-M-I-D-V-K-I-Y-V-D-K-V-I-E-N-N-Y-P-R-M-V-L-T-F-N-G-K-W-L-Y-Y-S-K-W


### FUNCTION Involved in ribosome biogenesis ### SEQUENCE -M-K-W-K-I-K-K-C-P-K-D-C-T-Y-T-L-K-D-I-C-P-I-C-G-T-P-T-I-I-P-H-P-A-R-F-S-P-V-D-K-Y-V-K-Y-R-I-E-I-K-K-G-I-K-L-N-C


### FUNCTION Degrades oligopeptides in a sequential manner ### SEQUENCE -M-T-I-T-K-R-K-N-T-F-Y-T-S-Q-F-I-S-Y-M-K-G-Y-Y-L-H-P-D-I-R-G-N-L-V-A-F-T-S-D-D-D-V-W-L-M-T-L-E-D-M-K-P-I-R-V-T-S-G-Q-G-V-A-I-R-P-K-I-S-P-D-G-K-K-I-A-Y-T-I-I-W-L-R-K-G-K-G-G-G-D-I-F-I-T-G-N-G-E-T-K-R-I-T-F-F-G-S-M-N-T-R-V-L-G-W-L-S-D-D-E-I-L-V-L-T-D-F-H-T-P-F-P-Q-W-S-E-T-Y-K-I-N-I-N-D-G-T-M-E-K-I-P-F-G-P-I-S-N-I-A-I-S-G-D-I-I-V-I-A-R-G-Y-Q-D-L-P-F-W-K-G-Y-K-G-G-T-K-G-E-F-L-I-S-Y-D-K-G-N-T


### FUNCTION Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate ### SEQUENCE -M-I-V-E-G-K-V-L-K-F-G-D-K-I-D-T-D-I-I-I-P-A-R-Y-L-K-Y-T-D-P-Q-Y-L-A-Q-H-A-M-E-P-L-D-P-E-F-Y-K-K-A-S-A-G-V-I-L-V-A-G-K-V-F-G-M-G-S-S-R-E-Q-A-A-I-A-L-K-A-A-G-V-R-A-I-I-A-E-S-F-A-R-I-F-Y-R-N-A-I-N-N-G-L-P-A-I-V-L-P-G-V-T-Q-L-I-N-E-G-D-Y-V-K-I-N-V-E-T-G-E-I-I-V-N-N-Q-K-V-Y-K-G-R-G-I-T-G-M-P-L-K-I-L-E-S-G-G-L-L-D-Y-L-K-K-V-S-V-Q-N-Q-G-G-N


### FUNCTION Catalyzes the synthesis of GMP from XMP ### SEQUENCE -M-K-I-A-V-I-Y-F-G-G-Q-Y-N-H-L-I-V-K-D-L-K-Y-L-G-L-N-A-V-L-I-T-P-E-K-P-V-E-I-L-K-D-Y-D-C-I-I-F-G-G-G-P-Y-S-V-I-T-E-L-N-K-M-G-N-A-V-D-Y-V-L-R-T-S-Q-P-K-L-G-I-C-L-G-H-Q-L-L-A-K-V-L-G-G-E-V-T-K-A-T-K-P-E-Y-G-L-V-K-V-N-I-N-D-E-D-T-I-L-R-G-L-S-P-S-I-N-A-W-E-S-H-T-D-E-V-I-S-P-P-Q-G-F-R-I-L-A-N-S-E-N-A-K-V-Q-A-M-V-N-K-D-N-T-I-F-G-V-Q-F-H-P-E-V-K-H-T-E-K-G-I-E-V-F-K-N-F-I-E-A-C-K-K


### FUNCTION eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA ### SEQUENCE -M-S-T-E-E-E-Y-I-K-L-L-D-R-L-Y-S-K-L-P-E-R-V-Q-K-V-S-G-Q-S-L-P-N-L-I-I-L-S-I-G-N-N-T-I-I-K-N-F-S-E-Y-C-D-R-I-R-R-E-D-K-L-C-A-K-F-I-L-K-E-L-A-A-P-G-N-V-D-E-N-G-Q-L-V-I-Q-G-K-F-S-S-A-S-I-N-K-I-M-E-R-F-I-K-T-Y-V-Q-C-S-T-C-K-S-L-D-T-V-L-I-K-E-K-K-A-W-Y-I-S-C-L-A-C-G-A-K-T-P-V-K-P-L


### FUNCTION Seems to be required for maximal rate of protein biosynthesis Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA ### SEQUENCE -M-A-K-K-K-T-N-E-Q-P-S-V-K-E-V-P-K-P-A-E-G-E-V-I-C-V-V-K-K-M-L-G-A-E-H-V-Q-V-I-C-L-D-G-K-E-R-L-G-R-I-P-G-K-M-K-K-K-M-W-V-K-E-G-D-V-V-L-A-A-P-W-D-F-Q-P-N-K-C-D-I-I-Y-K-Y-S-E-S-E-V-R-R-L-E-E-E-Q-V-V-S-A-D-I-I-E-Q-L-R-G


### FUNCTION Catalyzes the formation of CDP-2,3-bis- and CTP This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids ### SEQUENCE -M-P-I-I-Y-Y-V-I-F-A-I-L-Y-Y-L-P-A-L-V-A-N-G-S-A-P-F-V-K-N-G-T-P-I-D-F-R-K-N-F-V-D-G-R-R-L-L-G-D-G-K-T-F-E-G-L-L-V-A-V-T-F-G-T-T-V-G-I-I-L-A-K-F-L-G-I-Y-W-I-Y-V-S-F-I-E-S-L-L-A-M-L-G-D-M-V-G-A-F-I-K-R-R-L-G-L-A-R-G-A-R-A-I-G-L-D-Q-L-D-F-I-L-G-A-T-L-A-L-I-I-S-K-I-S-L-N-I-Y-E-F-L-S-I-V-V-I-A-F-V-L-H-I-L-T-N-N-V-A-Y-R-L-K-I-K-S-V-P-W


### FUNCTION Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends ### SEQUENCE -M-V-I-F-S-Y-R-T-R-I-I-Y-I-K-K-I-K-N-K-R-D-T-R-A-K-R-Y-V-I-F-D-I-I-S-E-D-N-F-E-I-R-E-I-E-E-A-V-R-N-S-V-K-E-L-G-G-K-I-W-L-D-L-S-N-P-K-V-I-M-I-Y-N-N-R-G-I-I-S-T-N-R-I-G-Y-K-I-I-I-A-S-L-P-L-I-K-K-I-K-N-K-E-V-L-L-V-P-R-R-T-T-G-S-L-K-R-A-K-R-L-I-G-I-E


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-T-E-R-I-P-P-E-L-Q-T-Q-L-V-K-L-Q-Q-L-Q-D-Q-L-N-R-L-L-T-E-K-N-V-I-D-S-E-L-R-E-V-N-K-I-L-Q-E-L-S-Q-L-P-A-G-T-T-V-Y-K-I-V-G-N-L-L-V-K-T-D-K-E-T-V-Q-K-E-L-D-D-R-K-E-I-L-E-L-R-S-R-T-Y-Q-K-Q-E-N-L-L-R-T-Q-L-E-D-L-Q-K-K-V-N-E-L-L-A-K-Y-Y-P-Q-S-G-G-A-I-K-A


### FUNCTION Binds to 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome ### SEQUENCE -M-I-I-K-E-F-L-T-T-E-K-A-I-K-L-I-E-S-Q-N-T-L-T-V-I-V-N-K-E-A-T-K-A-D-I-K-R-E-I-E-K-M-F-N-V-K-V-D-K-V-N-T-L-I-T-I-R-G-E-K-K-A-Y-V-K-L-K-K-E-F-N-A-S-D-I-A-H-R-L-G-I-L


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-S-L-E-I-P-P-E-W-K-K-F-R-Y-R-G-K-S-L-D-E-L-L-N-M-P-M-D-E-F-I-K-L-L-P-S-R-Q-R-R-S-L-K-K-G-F-S-D-K-Q-R-R-L-L-E-K-I-R-K-Y-V-R-E-G-K-Y-S-K-T-I-K-T-H-V-R-D-M-I-I-L-P-E-M-V-G-L-K-F-A-V-Y-N-G-K-E-F-V-E-F-Q-V-V-P-E-M-I-G-H-Y-L-G-E-F-S-I-T-T-K-K-V-E-H-G-E-P-G-L-K-A-T-R-S-S-L-F-L-A-M-K-G


### FUNCTION This protein binds specifically to 23S rRNA It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome ### SEQUENCE -M-A-G-W-T-Y-P-K-L-D-I-D-E-N-K-L-A-K-A-V-I-K-N-V-P-A-S-I-R-D-L-Y-N-V-C-K-A-I-R-G-M-K-L-N-D-A-K-Q-F-L-N-N-V-L-E-E-K-E-A-L-P-F-W-K-H-S-H-G-A-S-H-R-S-N-I-S-P-K-W-K-V-K-S-G-R-Y-P-K-K-A-I-K-Y-V-L-K-V-L-E-N-A-E-N-N-A-N-S-K-G-L-D-L-E-N-V-K-I-V-H-I-A-A-H-K-G-I-I-L-K-R-Y-M-P-R-A-F-G-R-S-T-R-K-Y-R-Y-T-S-H-I-E-V-I-L-G-E-V


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-G-K-K-G-A-L-V-K-N-I-G-I-E-G-V-N-P-P-S-K-T-C-D-D-I-N-C-P-F-H-G-N-L-R-V-R-G-I-I-L-E-G-R-L-I-R-Y-R-A-E-K-T-G-V-V-E-R-D-Y-L-F-Y-D-T-K-Y-K-R-Y-E-R-R-R-S-R-I-H-V-H-I-P-P-C-L-D-V-K-E-G-D-N-V-I-I-A-E-C-R-P-I-A-K-S-V-S-F-V-V-I-G-K-R


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-P-E-K-L-Q-V-L-G-S-R-K-G-L-T-P-G-L-Q-H-Y-T-T-V-T-V-A-D-N-S-G-A-K-E-A-V-I-I-G-I-Y-G-Y-K-G-V-L-R-R-I-P-F-A-N-I-A-D-L-V-M-V-S-V-R-K-G-T-P-E-V-R-K-Q-K-F-K-A-V-I-V-R-Q-R-M-P-F-R-R-P-D-G-T-W-I-A-F-E-D-N-A-V-V-I-V-N-P-D-G-T-P-K-G-T-E-I-R-G-P-I-A-K-E-A-A-E-R-W-P-K-V-A-S-I-A-T-M-V-I


### FUNCTION One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit ### SEQUENCE -M-V-S-H-K-P-S-K-Q-R-L-L-L-Y-N-L-P-K-H-Q-R-H-K-L-L-T-A-K-L-S-K-E-L-Q-Q-Q-Y-G-I-K-R-L-A-I-R-K-G-D-T-V-K-V-M-R-G-D-K-D-V-L-N-F-E-G-K-V-V-E-V-N-R-K-T-G-R-I-A-I-E-G-L-T-R-K-K-A-D-G-T-P-V-Y-R-W-I-H-A-S-K-V-I-I-T-K-L-D-L-S-D-A-K-R-K-E-I-I-E-R-K-R-K-A-R-E-E-Y-L-K-K-K-E-Q-T-T-E-A-K


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-A-E-T-Q-T-V-N-P-M-R-K-L-R-L-E-K-V-T-V-N-I-G-V-G-E-A-G-E-R-L-Q-K-A-Y-Q-L-L-Q-E-L-T-G-V-K-P-V-Y-T-I-A-K-R-T-I-R-E-F-G-V-R-K-G-A-P-I-G-V-K-V-T-L-R-G-K-K-A-E-E-F-L-N-K-V-L-A-A-V-G-H-R-I-K-A-S-S-F-D-E-Y-G-N-V-S-F-G-I-A-E-H-V-L-I-P-G-T-R-Y-D-P-E-I-G-I-F-G-M-D-V-A-I-T-L-V-R-P-G-F-R-V-A-R-R-R-R-K-K-A-H-I-P-K-R-H-R-T-V-S-K-E-E-A-M-E-F-L-K-Q-N-F-N-V-T-I-V-E-G


### FUNCTION Binds 16S rRNA, required for the assembly of 30S particles ### SEQUENCE -M-G-K-Y-K-P-P-A-E-R-K-Y-G-R-G-V-Q-V-C-R-R-C-G-S-R-D-S-V-I-Q-K-Y-G-L-Y-L-C-R-Q-C-F-R-E-V-A-Y-E-M-G-F-K-K-T-R


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-V-N-L-N-P-L-A-N-A-L-T-T-I-Y-N-N-E-M-R-R-N-K-Q-A-I-I-M-P-A-S-K-L-I-I-N-V-L-R-A-M-Q-K-E-G-Y-I-G-E-F-E-F-I-D-D-G-R-S-G-K-I-V-V-Q-L-L-G-R-I-N-K-C-G-P-I-A-P-R-Y-P-L-K-Y-K-D-L-L-T-L-P-D-Y-V-R-R-Y-L-P-S-K-E-I-G-V-L-I-I-S-T-N-K-G-V-M-T-H-K-D-A-I-R-E-R-I-G-G-V-A-L-G-Y-V-Y


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-K-A-V-H-L-Y-E-E-I-E-I-P-Q-G-I-N-V-N-I-E-G-M-K-I-K-V-K-G-P-K-G-E-I-E-K-D-F-S-H-I-S-G-I-E-I-R-K-E-D-N-K-I-V-V-E-T-T-F-A-D-R-R-K-K-A-Q-F-Y-S-I-I-A-H-I-E-N-M-F-T-G-V-T-K-G-Y-R-Y-Y-L-K-I-I-Y-T-H-F-P-V-T-V-K-V-S-G-N-E-V-Q-I-Q-N-L-I-G-E-K-N-I-R-R-A-K-I-M-T-G-V-K-V-N-V-K-G-E-D-I-I-V-E-G-Q-D-I-E-K-V-G-Q-T-A-A-N-I-E-L-A-S-K-I-T-G-Y-D-R-R-V-F-A-D-G-I-Y-I-Y-K-K-E-V-I-G-S-E-Q-T-D


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-A-H-G-P-N-Y-R-V-K-Y-R-R-R-R-E-G-K-T-N-Y-Y-K-R-Y-T-Y-V-I-N-N-T-T-R-L-V-V-R-L-T-N-K-Y-I-I-A-Q-I-A-K-F-N-P-K-G-D-V-I-V-V-A-A-H-S-M-E-L-A-K-K-F-G-W-K-G-D-L-N-N-T-P-A-A-Y-L-T-G-Y-L-L-G-V-R-A-L-K-A-G-I-K-E-A-V-A-D-I-G-L-F-V-P-V-K-G-S-R-I-F-T-A-I-K-G-A-I-D-A-G-L-S-I-P-V-G-D-L-G-I-K-E-D-R-I-K-G-V-H-I-A-S-Y-A-Q-K-L-E-A-E-N-P-E-L-F-K-R-L-F-S-K-Y-L-E-R-G-L-H-P-K-D-L-P-S-H-F-E-E-I-L-N-K-I-K-S-G-G-A


### FUNCTION Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently ### SEQUENCE -M-Q-K-F-E-F-F-E-H-T-A-D-I-G-I-R-A-Y-G-R-N-L-N-E-A-F-E-N-A-A-V-A-V-F-E-V-M-T-D-T-S-K-V-E-P-K-E-M-R-E-V-K-I-D-G-Y-D-L-E-N-L-L-Y-R-W-I-E-S-L-L-V-Y-Y-D-S-E-I-M-L-F-S-K-F-Y-V-N-I-D-E-K-N-L-T-L-E-G-K-A-W-G-E-K-F-D-P-N-K-H-E-R-R-T-V-V-K-A-M-T-Y-H-E-M-K-I-E-N-K-G-N-Y-Y-I-L-T-F-V-V-D-I


### FUNCTION Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-uracil with 3,4-dihydroxy-2-butanone 4-phosphate This is the penultimate step in the biosynthesis of riboflavin ### SEQUENCE -M-P-D-Q-S-I-N-L-A-I-V-V-A-E-F-N-Y-D-I-T-Y-L-M-L-Q-R-A-I-A-H-A-K-F-L-G-A-N-V-K-V-V-F-K-V-P-G-S-Y-D-M-A-I-A-V-K-E-L-L-K-R-D-D-I-D-A-V-V-T-L-G-A-V-I-K-G-E-T-K-H-D-E-I-V-A-T-Q-T-A-R-K-I-L-D-L-S-V-E-Y-G-K-P-V-T-L-G-I-I-G-H-G-V-T-H-E-Q-A-V-E-R-I-E-E-Y-S-T-R-A-V-E-A-A-I-K-L-A-K-R-L-R-E-L-R-K-I-Q-T-L-N-E-E-M-V-V-I-E


### FUNCTION Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A ### SEQUENCE -M-P-D-S-I-K-K-E-L-T-R-P-Y-G-F-L-F-T-N-N-D-I-F-I-N-F-I-L-E-K-K-N-N-R-L-I-T-V-G-D-V-V-T-S-T-L-Y-D-R-N-I-I-P-F-L-S-I-I-D-G-K-T-K-R-Q-I-K-V-K-T-V-N-E-N-V-I-K-V-K-N-E-K-S-T-I-R-F-S-V-M-K-I-I-K-N-L-L-D-K-N-E-R-A-T-I-L-V-D-G-E-E-D-L-L-V-I-P-V-V-I-F-G-R-N-N-D-I-I-V-Y-G-Q-P-N-A-G-A-V-V-I-I-N-N-H-F-V-K-I-R-V-K-Q-I-L-E-K-F-Y-V-K-K-C


### FUNCTION Endonuclease that removes tRNA introns Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp ### SEQUENCE -M-I-G-E-L-V-K-D-K-I-L-I-K-N-I-E-D-A-R-L-I-Y-K-M-G-Y-Y-G-K-P-I-G-I-S-K-P-K-S-A-E-E-I-N-S-E-L-I-L-S-L-I-E-G-V-Y-L-V-K-K-G-K-L-E-I-V-S-N-G-E-R-L-D-F-E-R-L-Y-Q-I-G-V-T-Q-I-P-R-F-R-I-L-Y-S-V-Y-E-D-L-R-E-K-G-Y-V-V-R-S-G-I-K-Y-G-A-D-F-A-V-Y-T-I-G-P-G-I-E-H-A-P-Y-L-V-I-A-L-D-E-N-S-Q-I-S-S-N-E-I-L-G-F-G-R-V-S-H-S-T-R-K-E-L-I-L-G-I-V-N-L-T-N-G-K-I-R-Y-I-M-F-K-W-L-K-M


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-K-G-T-P-S-F-G-K-M-N-K-S-P-T-H-V-R-C-R-R-C-G-R-N-S-F-N-V-R-K-G-Y-C-A-A-C-G-F-G-R-S-K-K-I-R-R-Y-N-W-Q-N-K-K-V-N-G-L-R-L-V


### FUNCTION Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein  and RNA polymerase recruitment Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes ### SEQUENCE -M-S-S-R-A-E-E-L-I-L-S-L-A-K-D-L-V-G-E-D-A-T-E-L-L-K-F-L-L-R-K-R-I-E-M-T-D-D-D-I-A-K-E-L-N-V-K-V-N-E-I-R-K-K-L-Y-L-L-S-E-Q-G-F-I-T-Y-R-K-T-R-D-K-E-T-G-L-F-I-Y-Y-W-K-V-N-I-D-Q-I-N-E-L-L-L-N-R-K-R-L-V-L-E-K-L-K-A-R-Y-E-Q-E-K-D-S-L-Y-Y-Y-C-P-Q-D-N-I-Q-Y-N-F-D-E-A-L-E-N-E-F-K-C-P-K-C-G-S-P-L-E-Y-Y-D-S-E-K-T-K-K-F-L-E-Y-K-I-K-Q-I-E-N-E-I-E-R-E-T-R-H-G-S-N-S-R


### FUNCTION Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs ### SEQUENCE -M-H-H-R-P-E-R-D-K-R-V-T-T-H-V-A-L-V-A-R-A-F-G-A-K-G-I-F-I-H-G-E-D-M-N-L-L-K-T-I-E-K-V-K-A-N-W-G-G-K-Y-F-S-I-E-F-V-K-N-P-K-K-V-V-R-D-W-R-N-S-G-G-I-V-V-H-L-T-M-Y-G-I-P-I-D-N-I-M-E-K-I-I-N-K-N-T-K-I-L-V-V-V-G-S-E-K-V-E-G-W-Y-Y-Y-N-S-D-Y-N-I-A-I-G-N-Q-P-H-S-E-V-A-A-L-A-I-F-L-D-R-I-Y-K-G-G-E-L-N-I-Q-F-S-D-A-K-L-S-I-I-P-Q-E-R-G-K-K-V-R-K-N-E


### FUNCTION Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in Mjannaschii 16S rRNA It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3- ### SEQUENCE -M-K-V-Y-I-I-D-Y-H-R-D-D-P-K-K-C-T-G-R-K-L-I-K-L-N-F-A-E-L-T-R-Y-G-K-G-I-I-L-D-P-Y-S-K-R-I-L-S-I-L-D-K-D-I-A-L-K-T-G-I-T-I-V-D-T-S-W-N-S-T-S-K-I-E-F-E-K-I-K-G-E-H-R-R-L-P-I-L-F-A-G-N-P-T-N-Y-G-I-A-Y-K-L-S-S-I-E-A-V-I-A-S-L-Y-I-L-N-E-V-E-E-A-I-K-I-A-N-I-I-K-W-G-H-T-F-L-E-L-N-K-E-L-L-E-S-Y-R-N-K-S-E-N-E-I-L-E-I-E-R-E-V-I-E-K-I-I-G-E-P


### FUNCTION Involved in protein export The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex ### SEQUENCE -M-P-S-S-K-K-K-K-E-T-V-P-L-A-S-M-A-G-L-I-R-Y-Y-E-E-E-N-E-K-I-K-I-S-P-K-L-L-I-I-I-S-I-I-M-V-A-G-V-I-V-A-S-I-L-I-P-P-P


### FUNCTION With S4 and S5 plays an important role in translational accuracy Located at the interface of the 30S and 50S subunits ### SEQUENCE -M-A-G-G-K-S-P-K-G-M-F-A-A-R-K-L-R-L-K-R-L-K-F-R-W-H-Q-R-K-F-K-R-R-M-L-K-L-K-E-K-F-D-P-L-E-G-A-P-M-A-R-G-V-V-L-E-K-V-G-I-E-S-R-Q-P-N-S-A-V-R-K-A-V-R-V-Q-L-V-K-N-G-R-I-V-T-A-F-V-P-G-D-G-G-V-N-F-I-D-E-H-D-E-V-V-I-A-G-I-G-G-T-L-G-R-S-M-G-D-L-P-G-V-R-Y-K-V-I-M-V-N-G-V-S-L-D-A-L-Y-K-G-K-K-Q-K-P-V-R


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit Is located at the subunit interface close to the decoding center ### SEQUENCE -M-E-S-F-E-V-S-S-I-D-L-K-V-F-G-K-W-D-T-K-V-E-I-R-D-P-S-L-K-K-Y-I-G-L-M-P-V-Y-L-P-H-T-G-G-R-H-E-H-R-R-F-G-K-A-K-L-P-I-V-E-R-L-I-N-N-V-M-R-P-G-R-N-K-G-K-K-M-L-A-Y-N-I-V-K-T-A-F-D-I-I-A-L-K-T-G-Q-N-P-I-Q-V-L-V-K-A-I-E-N-S-A-P-R-E-E-V-T-R-I-M-Y-G-G-I-V-Y-Y-V-A-V-D-V-A-P-Q-R-R-V-D-L-A-L-R-H-L-V-M-G-A-K-E-A-S-F-N-N-P-K-P-I-E-E-A-L-A-E-E-I-I-A-A-A-S-N-D-P-K-S-F-A-I-R-K-K-E-E-I-E-R-I-A-L-S-S-R


### FUNCTION Involved in the binding of tRNA to the ribosomes ### SEQUENCE -M-P-T-K-A-R-I-R-L-W-S-T-N-I-E-N-L-N-F-V-V-N-Q-I-K-T-L-A-Q-K-T-G-V-E-I-S-G-P-I-P-L-P-T-S-R-M-E-V-P-V-M-R-L-P-H-G-E-G-K-K-K-W-E-H-W-E-M-K-I-H-K-R-I-I-D-I-A-S-D-E-R-V-M-R-Q-L-M-R-V-R-V-P-D-D-V-Y-I-E-I-E-L-I


### FUNCTION Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA ### SEQUENCE -M-T-D-V-L-V-V-V-K-V-F-P-E-S-D-E-V-N-L-D-N-L-Y-E-E-I-G-K-K-L-P-A-G-Y-K-L-V-R-K-E-T-E-P-I-A-Y-G-L-K-A-L-I-A-Y-V-Q-M-P-E-N-V-E-G-G-T-D-T-L-E-E-I-I-N-S-I-Q-G-V-S-H-A-E-V-V-G-I-T-R-L-G-F


### FUNCTION The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis ### SEQUENCE -M-A-T-K-M-V-I-V-V-R-T-D-L-D-M-G-K-G-K-I-A-A-Q-V-A-H-A-A-V-S-L-V-L-D-I-L-N-S-S-N-S-L-W-K-E-W-L-Y-K-W-L-E-E-G-Q-P-K-I-V-V-K-V-P-S-L-D-E-L-N-K-R-Y-E-K-A-I-E-L-N-L-P-T-T-I-I-Q-D-A-G-K-T-Q-I-E-P-G-T-I-T-C-I-G-I-G-P-A-P-V-E-L-V-D-K-I-T-G-D-L-K-L-L


### FUNCTION In the absence or at low concentrations of lysine, activates the biosynthesis of this amino acid via the alpha-aminoadipate  pathway ### SEQUENCE -M-A-D-V-D-E-S-D-L-K-I-L-E-I-L-R-K-N-A-R-T-P-Y-T-S-I-A-K-E-L-K-I-S-E-A-A-V-R-K-R-I-E-K-L-I-K-M-G-V-I-K-R-F-T-I-D-Y-E-L-E-N-E-I-R-A-I-V-M-V-K-T-N-P-Q-I-P-T-P-E-I-S-K-K-I-I-K-I-Q-G-V-E-F-V-Y-E-T-T-G-D-Y-D-I-L-T-V-V-R-G-T-N-I-S-S-I-N-K-T-I-D-D-I-R-S-L-Q-G-V-L-S-T-N-S-T-I-V-L-R-V-W-F


### FUNCTION Broad-specificity nucleoside monophosphate  kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates ### SEQUENCE -M-I-I-I-I-T-G-T-P-G-S-G-K-S-T-I-V-D-L-L-S-K-K-L-G-F-E-K-L-H-V-S-S-F-L-I-Q-N-K-A-F-S-E-Y-D-E-L-R-Q-S-Y-V-I-D-E-E-K-A-F-Q-L-I-D-S-F-I-K-D-K-N-V-V-I-E-T-I-Y-P-S-L-I-S-H-A-D-K-V-I-V-L-R-K-D-P-R-V-L-Y-T-E-L-K-R-R-G-W-G-E-L-K-I-A-E-N-V-M-A-E-I-L-G-V-I-S-G-E-A-K-E-Y-F-G-N-I-C-E-I-N-V-T-N-K-K-P-E-E-V-V-E-Q-I-L-S-N-N-C-D-N-V-D-W-L-N-I-E-E-I-Q-D-L-L-I-S-L-D-K-V-I-S-S-Y-E-D-S-I-S-D-E


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-S-L-M-D-P-L-A-N-A-L-N-H-I-S-N-C-E-G-V-G-K-S-V-A-Y-V-K-P-A-S-K-L-I-G-R-V-L-N-V-M-Q-D-H-G-Y-I-G-N-F-E-Y-I-E-D-G-R-A-G-I-Y-K-V-E-L-I-G-Q-I-N-K-C-G-A-V-K-P-R-Y-A-V-K-K-Q-E-F-E-K-F-E-K-R-Y-L-P-A-K-G-F-G-L-L-I-V-S-T-P-K-G-L-M-T-H-D-E-A-K-N-Q-G-L-G-G-R-L-I-S-Y-V-F


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-S-L-M-D-P-L-A-N-A-L-N-H-I-S-N-C-E-N-V-G-K-N-T-A-Y-L-K-P-A-S-K-L-I-G-R-V-L-K-V-M-Q-D-Q-G-Y-I-G-N-F-E-Y-I-E-D-G-K-A-G-V-Y-K-V-T-L-I-G-Q-I-N-K-C-G-A-V-K-P-R-F-A-V-K-N-Q-E-F-E-K-F-E-K-R-Y-L-P-A-K-G-F-G-L-L-I-V-S-T-P-K-G-L-M-T-H-D-E-A-K-D-S-G-I-G-G-R-L-I-S-Y-I-Y


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-S-L-M-D-P-L-A-N-A-L-N-H-L-T-N-C-E-R-V-G-K-K-V-F-Y-I-K-P-A-S-K-L-I-G-R-V-L-K-V-M-Q-D-H-G-Y-I-G-E-F-E-F-I-E-D-G-R-A-G-I-F-K-V-E-L-I-G-K-I-N-K-C-G-A-I-K-P-R-Y-A-V-K-K-H-E-F-E-K-F-E-K-R-Y-L-P-A-R-D-F-G-L-L-I-V-S-T-S-Q-G-I-M-T-H-Y-E-A-K-E-K-G-I-G-G-R-L-I-S-Y-V-Y


### FUNCTION Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions ### SEQUENCE -M-A-W-K-V-S-V-D-V-D-T-C-I-G-D-A-I-C-A-S-L-C-P-D-V-F-E-M-G-D-D-G-K-A-H-P-V-V-E-T-T-D-L-D-C-A-Q-E-A-A-E-A-C-P-V-G-A-I-T-L-E-E-A


### FUNCTION Catalyzes the conversion of ### SEQUENCE -M-I-D-F-D-G-N-M-I-N-I-S-R-K-D-V-V-A-R-K-A-T-A-V-G-R-I-Y-L-R-K-E-T-I-T-A-I-K-N-N-Q-V-K-K-G-N-V-I-E-I-S-R-A-V-G-T-M-Y-A-K-N-T-F-L-Q-I-P-Y-C-H-N-I-P-I-E-G-V-D-V-D-F-S-L-G-E-N-Y-V-E-V-T-C-S-T-T-T-S-Y-K-T-G-I-E-M-E-A-I-N-C-V-N-G-A-L-L-N-I-W-D-M-V-K-Y-L-E-K-D-E-T-G-N-Y-P-E-T-R-I-E-G-V-H-V-I-K-K-T-K-S-Q-E


### FUNCTION General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation ### SEQUENCE -M-S-E-R-E-K-I-T-I-E-N-I-V-A-S-T-S-L-A-E-H-L-D-L-S-R-I-A-L-A-L-D-G-S-E-Y-E-P-E-Q-F-P-G-L-I-Y-R-L-Q-D-P-K-T-A-V-L-I-F-R-S-G-K-V-N-C-T-G-A-K-N-I-E-D-V-K-R-T-I-K-I-I-I-D-K-L-K-A-A-N-I-E-V-Y-D-D-P-D-I-I-V-Q-N-I-V-A-V-Y-D-L-E-S-E-L-N-L-T-D-I-A-M-S-L-G-L-E-N-V-E-Y-E-P-E-Q-F-P-G-L-V-Y-R-V-E-E-P-R-V-V-L-L-L-F-G-S-G-K-V-V-C-T-G-A-K-E-E-S-E-I-E-Q-A-V-I-K-V-K-K-E-L-Q-K-V-G-L-I


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-V-E-P-N-I-S-S-Y-L-Q-N-Q-L-K-Q-A-Q-E-L-E-E-N-I-E-K-I-A-T-Q-R-Y-Q-L-D-L-S-L-K-E-I-E-K-T-L-Q-E-L-N-K-I-D-D-K-T-P-V-Y-R-S-I-G-S-I-L-Y-K-V-D-D-K-K-K-L-I-D-E-L-E-E-Q-L-E-L-T-K-I-R-I-N-T-L-D-K-Q-Q-K-S-L-E-E-K-Y-K-E-L-Q-A-A-I-R-E-R-Y-N-Q-D-N-K-K-G-A-V-S


### FUNCTION Seems to be required for maximal rate of protein biosynthesis Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA to 40 S ribosomal subunits ### SEQUENCE -M-S-P-D-K-T-E-D-E-D-K-D-V-N-V-D-Q-D-Q-F-N-E-E-E-E-S-L-G-R-V-I-L-P-N-K-K-K-G-E-M-F-G-I-V-E-K-M-E-G-A-S-R-L-S-V-M-C-E-D-G-Y-T-R-N-A-R-I-P-G-R-M-R-K-R-M-W-I-R-E-K-D-L-V-I-V-K-P-W-E-F-Q-P-E-K-A-D-V-V-Y-R-Y-T-K-T-Q-A-S-Y-L-S-R-N-H-M-L-P-E-V-I-D-I-F-K


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-K-I-I-D-A-S-N-T-V-Y-G-R-L-S-A-Y-V-A-K-Q-L-L-N-G-E-E-V-V-I-V-N-A-S-K-A-V-I-T-G-D-R-K-F-I-I-D-K-F-K-Q-R-L-D-I-G-S-V-R-K-G-P-Y-Y-P-K-T-P-E-N-I-L-R-R-S-I-G-D-M-L-P-K-K-I-T-R-G-K-E-A-L-S-R-C-K-V-Y-R-N-L-P-K-N-V-S-S-E-K-I-E-K-V-D-D-V-M-T-D-K-V-V-G-I-I-T-L-E-E-L-S-K-E-L-G-G-M


### FUNCTION Binds double-stranded DNA tightly but without sequence specificity It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture However, it does not significantly compact DNA Binds rRNA and mRNA in vivo May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes ### SEQUENCE -M-A-E-E-N-I-I-F-V-G-K-K-P-T-M-N-Y-V-L-A-V-V-T-Q-F-N-N-N-A-N-K-I-I-I-K-A-R-G-K-T-I-S-K-A-V-D-V-A-E-I-T-R-H-K-F-I-P-D-A-K-Y-E-E-I-R-L-D-T-E-T-L-Q-G-E-R-G-S-S-N-V-S-S-I-E-I-T-L-S-R


### FUNCTION Involved in the binding of tRNA to the ribosomes ### SEQUENCE -M-A-S-Y-K-A-R-I-S-L-S-G-T-E-H-K-I-V-D-M-V-C-S-E-I-K-E-I-A-S-R-T-G-V-E-I-H-G-P-M-P-L-P-T-K-K-L-V-V-P-V-R-K-S-P-D-G-E-G-T-N-T-W-D-H-W-E-M-R-I-H-K-R-L-I-D-V-D-A-D-E-R-T-L-R-Q-L-M-R-I-P-I-P-D-G-V-Q-I-E-I-Q-I-K-S


### FUNCTION Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently ### SEQUENCE -M-T-Y-E-I-L-D-H-E-S-D-I-G-I-M-V-Y-G-T-T-Y-E-E-L-F-S-N-A-V-Y-A-M-A-D-L-I-L-D-V-G-K-L-K-E-K-R-K-M-H-E-I-I-R-G-N-T-P-E-D-I-M-V-N-L-L-S-R-V-L-F-Y-V-D-T-Y-Y-T-L-Y-F-R-A-T-C-K-Y-E-D-S-T-L-D-V-Y-L-Y-G-S-E-I-P-E-E-V-E-Y-R-N-V-I-K-A-V-T-Y-S-E-I-A-V-K-P-E-D-G-F-A-R-V-I-F-D-L


### FUNCTION Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP May hydrolyze nucleoside diphosphates with lower efficiency ### SEQUENCE -M-A-I-K-I-G-I-T-G-P-V-G-S-I-K-A-E-A-L-Q-K-I-I-G-M-L-Q-N-D-G-L-N-V-Q-G-V-L-I-S-K-V-S-D-D-G-K-L-T-G-Y-T-I-E-D-I-L-T-K-K-K-V-Q-F-C-D-E-K-F-V-S-R-V-K-I-D-K-L-G-V-D-T-R-L-L-E-E-I-L-I-P-S-L-Q-K-A-R-E-S-A-D-V-I-I-I-D-E-V-G-K-L-E-N-T-T-K-K-I-H-S-E-I-E-E-T-L-K-C-G-K-P-L-I-V-T-L-H-K-R-S-R-N-P-V-L-Q-E-I-K-S-L-E-G-V-R-V-F-D-I-T-P-I-N-K-N-I-L-P-F-K-V-M-H-V-L-K-G-E-E


### FUNCTION Involved in allosteric regulation of aspartate carbamoyltransferase ### SEQUENCE -M-E-E-K-T-L-K-I-S-K-I-K-D-G-T-V-I-D-H-I-P-S-G-K-A-L-R-V-L-S-I-L-G-I-R-D-D-V-D-Y-T-V-S-V-G-M-H-V-P-S-S-K-M-E-Y-K-D-V-I-K-I-E-N-R-S-L-D-K-N-E-L-D-M-I-S-L-T-A-P-N-A-T-I-S-I-I-K-N-Y-E-I-S-E-K-F-K-V-E-L-P-P-K-L-I-G-I-I-K-C-K-N-Q-N-C-I-T-N-T-R-E-P-V-K-P-E-F-E-I-V-S-R-H-P-L-V-L-R-C-V-Y-C-Q-R-T-M-N-E-R-D-V-F-E


### FUNCTION Broad-specificity nucleoside monophosphate  kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates ### SEQUENCE -M-G-K-I-A-C-I-T-G-P-P-G-A-G-K-S-T-V-C-S-K-L-R-E-Y-G-Y-N-C-K-E-G-N-E-L-A-K-E-Y-G-C-L-F-D-E-E-V-D-V-E-C-L-E-E-K-L-A-E-D-R-F-D-G-I-I-C-S-H-Y-S-H-L-L-G-C-S-T-V-F-I-L-E-A-D-L-N-D-L-I-D-R-M-R-A-R-G-Y-S-E-E-K-I-Q-E-N-I-E-T-Q-M-S-S-I-F-Y-Y-E-S-L-E-R-L-P-A-N-R-I-F-T-L-Y-N-G-N-I-D-E-T-A-K-R-I-I-S-I-I-E-R-S-R-N-N-K


### FUNCTION Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA ### SEQUENCE -M-A-D-V-L-V-S-F-K-L-L-P-S-D-S-D-V-D-T-S-V-M-E-S-E-V-K-E-K-L-N-G-V-C-K-I-N-N-I-E-E-K-D-I-G-F-G-L-K-Y-I-H-L-E-V-I-V-E-D-K-E-G-E-V-D-R-I-E-K-V-L-S-M-V-K-G-V-G-E-I-N-T-E-N-V-S-L-I


### FUNCTION Located on the platform of the 30S subunit ### SEQUENCE -M-E-V-N-R-M-N-K-T-G-I-A-H-I-Y-A-S-Q-N-N-T-I-I-H-V-T-D-P-T-G-A-E-T-I-A-M-V-S-G-G-M-V-V-K-N-D-R-D-Q-A-S-P-Y-A-A-M-K-A-A-D-M-V-S-E-T-L-K-E-H-E-I-T-D-L-I-I-K-V-R-A-P-G-G-N-K-S-K-I-P-G-P-G-A-Q-A-A-I-R-A-L-S-R-A-G-L-K-I-V-R-I-E-E-V-T-P-I-P-H-D-G-T-K-K-K-G-G-K-R-G-R-R-V


### FUNCTION Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA In the 70S ribosome it contacts the 23S rRNA , connecting the 2 subunits ### SEQUENCE -M-G-K-A-S-A-N-N-V-K-S-D-K-E-A-A-K-P-A-A-K-K-D-E-N-K-D-F-Q-Y-I-V-R-I-A-N-K-D-L-N-G-E-R-P-I-P-L-A-L-S-D-L-K-G-I-G-L-R-L-G-Y-A-I-A-E-R-L-N-L-Q-P-T-K-K-I-G-E-L-K-E-D-E-I-E-K-L-K-E-Y-V-E-N-K-E-Y-D-L-P-D-W-L-L-N-H-R-R-E-P-V-T-G-K-N-L-N-L-V-T-T-D-L-D-V-Q-V-Q-E-D-I-N-L-M-K-K-I-R-S-Y-K-G-I-R-H-E-K-G-K-K-V-R-G-Q-R-T-R-S-N-G-R-R-G-L-S-I-G-V-V-R-K-K-E


### FUNCTION Functions by promoting the formation of the first peptide bond ### SEQUENCE -M-S-W-Q-E-A-E-V-R-E-L-K-V-G-R-Y-I-L-I-D-D-V-P-C-K-I-V-E-I-T-M-S-K-P-G-K-H-G-E-A-K-G-R-I-V-A-I-G-V-F-D-N-Q-K-R-S-V-V-Y-P-V-K-H-K-V-K-I-P-I-I-E-K-K-N-A-Q-V-L-S-V-M-N-N-E-A-Q-L-M-D-S-E-T-F-E-T-F-V-L-P-L-D-P-E-I-A-D-K-V-K-P-G-M-E-V-P-Y-W-E-A-M-G-V-R-K-I-M-L-Q-N


### FUNCTION Molecular chaperone capable of stabilizing a range of proteins Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding ### SEQUENCE -M-A-R-D-V-E-A-Q-L-N-Y-I-E-S-L-I-S-S-V-D-A-Q-I-D-A-I-N-K-M-V-L-E-V-Q-T-T-I-Q-I-L-S-S-D-E-L-R-Q-S-K-E-R-L-I-S-V-G-S-G-I-F-A-N-G-N-L-D-L-D-S-D-L-I-V-P-I-G-S-G-V-Y-I-A-E-K-R-S-E-T-I-E-R-L-K-A-N-I-E-N-L-K-E-S-I-Q-K-L-M-D-Q-R-R-T-L-V-D-Q-Y-N-T-V-Y-T-T-E-A-T-R-N-I-K


### FUNCTION Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ ### SEQUENCE -M-Y-S-P-S-S-S-N-Y-I-K-D-P-I-S-T-E-I-I-K-S-K-T-R-N-L-K-K-R-A-E-E-A-I-L-Y-R-S-I-A-E-Q-S-S-R-K-L-A-E-I-S-E-A-Y-K-H-K-L-A-D-M-E-N-Y-L-K-I-K-D-R-E-T-E-I-I-R-K-N-A-N-E-S-L-I-K-D-F-L-P-V-I-D-S-M-D-A-A-I-Q-A-E-K-D-N-N-L-I-R-I-R-D-Q-M-L-S-I-L-S-K-Y-G-L-Q-P-I-K-A-E-G-E-K-F-D-P-Y-L-H-E-A-I-G-M-T-Q-D-G-E-D-G-K-I-K-Y-E-V-Q-R-G-Y-T-L-N-N-S-V-L-R-T-S-K-V-I-V-V-K-R


### FUNCTION Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A ### SEQUENCE -M-L-L-R-S-G-S-K-Y-I-I-T-A-E-A-R-E-E-I-K-K-R-N-G-K-L-V-T-I-D-E-M-V-E-V-S-K-S-T-Q-L-D-S-V-G-D-V-T-T-T-N-L-R-R-A-G-A-K-L-F-L-Q-I-V-D-L-K-T-K-R-G-E-S-I-F-Q-H-E-E-G-S-I-T-V-R-N-D-P-G-T-I-S-F-D-L-I-E-A-I-K-S-S-I-E-N-N-K-P-T-R-I-E-V-I-G-E-E-D-L-A-V-L-P-I-I-Y-Y-S-K-N-N-T-V-I-A-Y-G-I-P-D-V-G-M-A-A-L-T-V-T-D-D-L-R-D-H-V-T-E-V-I-A-K-M-A-I-E


### FUNCTION Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors ### SEQUENCE -M-A-Q-S-V-K-T-M-V-E-G-G-K-A-T-T-G-P-P-I-G-P-A-L-G-P-L-G-L-N-V-A-Q-V-V-K-E-I-N-E-K-T-K-E-F-Q-G-M-Q-V-P-V-T-V-T-V-I-D-P-E-T-K-K-Y-E-I-T-V-G-V-P-P-T-S-A-L-L-K-K-E-L-G-L-E-K-G-A-S-K-K-K-E-A-V-A-G-N-A-T-L-E-Q-I-K-N-V-A-I-K-K-M-P-S-M-L-A-K-D-L-K-S-A-V-L-E-V-L-G-T-C-V-A-M-G-I-N-V-E-G-K-D-P-K-E-V-Q-K-L-I-K-S-G-Q-I-K-I-E-Q


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-S-N-G-T-A-V-M-G-K-I-N-N-K-K-T-H-I-T-C-R-R-C-G-H-H-T-Y-N-V-R-T-K-R-C-S-H-C-G-F-P-A-P-R-I-R-S-Y-K-W-A-K-A-K


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-V-R-E-R-T-K-K-L-R-G-G-H-Y-G-R-G-M-K-A-G-R-G-K-G-K-K-G-G-R-G-N-A-G-M-G-K-H-K-W-I-W-M-V-K-Y-D-P-L-H-F-G-G-K-G-F-T-S-H-H-L-S-T-P-D-V-P-I-N-L-G-E-L-E-N-I-F-E-N-L-K-A-D-G-F-V-R-E-E-N-G-E-T-V-V-D-L-K-A-A-G-Y-D-K-L-L-G-S-G-N-F-S-V-K-S-R-I-I-I-D-K-A-T-E-K-A-I-S-K-L-S-A-I-G-S-K-I-E-N-V-G-N-T-A-E


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-A-F-K-R-K-V-L-G-K-T-D-Y-G-R-R-L-R-L-L-K-S-K-D-R-R-F-I-V-R-I-T-N-K-G-I-I-A-Q-I-A-E-Y-S-V-N-G-D-R-I-L-A-T-I-T-D-K-A-L-S-K-Y-G-I-E-L-R-G-N-N-L-Q-I-C-Y-L-V-G-Y-A-A-G-V-E-A-Q-K-A-G-V-E-T-A-V-L-D-I-G-R-K-K-F-R-K-G-G-R-I-A-A-C-L-K-G-I-T-D-S-G-V-D-I-P-H-G-E-D-V-F-P-D-K-K-R-L-N-G-S-H-L-K-N-P-V-K-L-N-E-A-V-K-N-F-K-K-L-E-E-K-A


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-I-K-W-E-E-A-S-V-I-E-I-P-K-D-V-K-V-G-L-S-G-T-M-L-S-M-T-F-G-N-K-K-L-E-K-K-F-A-D-N-Y-V-R-L-L-V-E-D-N-K-I-K-I-V-K-S-K-N-N-S-R-E-R-G-I-V-G-T-W-A-S-E-I-S-N-M-V-K-G-L-K-E-G-F-Q-Y-E-M-K-I-D-Y-S-H-F-P-M-R-V-S-V-K-G-K-T-V-V-I-E-N-F-F-G-E-R-S-P-R-T-A-E-I-V-G-E-T-Q-V-S-V-K-G-D-R-L-F-L-N-G-P-S-K-K-D-V-G-E-T-A-A-N-I-E-R-A-T-I-I-K-G-F-D-P-R-V-F-Q-D-G-I-Y-L-I-S-K-G-E


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-R-N-D-T-L-N-D-V-I-N-S-I-K-N-A-S-R-L-G-R-R-E-I-I-A-E-P-A-A-K-L-I-G-K-V-L-K-V-M-Q-D-Y-N-Y-I-K-S-F-E-V-I-D-E-S-R-G-G-K-F-K-I-V-L-N-T-T-I-N-N-C-G-V-I-K-P-R-F-P-V-K-N-E-N-L-E-K-Y-E-S-R-Y-L-P-A-E-D-F-G-I-L-I-L-T-T-T-K-G-V-M-S-N-I-E-A-R-K-L-G-I-G-G-K-L-L-A-Y-V-Y


### FUNCTION Binds 16S rRNA, required for the assembly of 30S particles ### SEQUENCE -M-S-Q-V-K-L-Q-P-K-K-K-Y-G-H-I-D-G-C-V-R-C-G-R-K-R-G-I-V-R-K-Y-G-L-H-L-C-R-Q-C-F-R-E-T-A-R-Q-L-G-F-E-K-Y-S


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-N-Q-M-Q-E-I-I-I-D-K-V-V-V-N-I-G-V-G-Q-A-G-D-R-L-T-K-A-A-K-V-L-E-M-L-T-G-H-K-P-T-Q-T-L-A-K-K-S-V-R-D-F-N-I-R-K-R-L-P-I-G-V-K-V-T-L-R-K-D-D-A-V-N-F-L-N-K-A-L-Y-V-K-D-Y-K-I-P-D-Y-S-F-D-K-H-G-N-A-Y-F-G-I-S-D-Y-T-D-F-K-G-M-K-Y-D-P-D-I-G-I-F-G-M-D-V-A-I-V-L-K-R-R-G-G-Y-R-I-E-K-R-K-I-G-K-K-T-I-P-S-S-I-R-I-K-K-D-E-A-V-E-F-L-E-K-N-F-K-V-S-V-V-R


### FUNCTION One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit ### SEQUENCE -M-Y-D-K-L-N-V-A-L-S-K-D-L-R-K-K-Y-G-I-R-S-F-P-I-V-K-G-D-V-V-K-V-V-S-G-A-R-K-G-E-G-G-K-V-A-E-V-D-H-H-S-G-L-V-I-V-E-G-I-T-I-A-K-I-D-G-K-Q-K-G-F-G-I-S-P-E-K-L-Q-I-T-H-L-D-L-S-R-S-E-R-F-Q-K-I-K-E-L-A-N-I-K-H-I-T-I-Q-E-E-P-I-Q-E-E-Q-Q-K-T-E-E-T-K-Q-E-I-A-P-E-E-V-E-A-K-E-A-Q-D-K-Q-E-V-K-E-N-D-Q


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-K-G-I-A-G-R-E-I-R-G-L-P-L-G-A-N-I-V-C-A-D-N-T-G-A-R-S-I-S-L-I-D-V-K-A-Y-H-G-K-A-R-R-I-P-A-A-G-V-G-D-M-F-I-A-S-V-K-K-G-T-P-E-M-R-S-K-V-V-Y-A-V-V-I-R-Q-K-R-P-Y-R-R-P-D-G-T-M-V-E-F-E-D-N-A-A-V-L-V-T-P-D-G-E-V-R-G-S-E-I-K-G-P-V-A-R-E-A-A-E-R-W-P-R-I-A-A-I-A-S-I-I-V


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-Q-A-R-N-I-G-L-D-V-S-V-P-E-K-E-C-T-D-P-H-C-P-F-H-G-N-L-P-V-R-G-Q-V-L-T-G-K-V-I-S-T-A-M-T-R-S-V-V-V-A-R-E-Y-Q-Q-Y-I-P-K-Y-E-R-K-A-T-K-I-K-K-Y-H-V-H-V-P-D-C-I-E-L-R-V-G-D-T-V-R-F-A-E-C-R-K-L-A-K-T-I-S-F-V-V-V-E-K-V-K-Q


### FUNCTION Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends ### SEQUENCE -M-I-Y-I-S-E-F-I-G-R-H-V-E-V-I-Q-S-S-N-R-Y-D-V-G-I-S-G-Q-V-S-F-E-T-K-N-T-F-E-I-T-K-G-T-G-K-V-I-V-P-K-E-G-R-I-F-T-F-D-G-K-F-K-V-D-G-S-L-I-N-Y-R-P-E-D-R-L-R-E-Y-R-K-I-L-K-K-L-G-G-N


### FUNCTION This protein binds specifically to 23S rRNA It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome ### SEQUENCE -M-K-G-Y-S-M-S-V-D-E-N-N-A-R-A-R-I-V-E-A-D-I-S-L-K-D-A-V-N-I-A-H-H-I-R-G-M-K-L-D-Y-A-K-Q-I-L-E-D-V-V-S-K-K-Y-A-I-P-Y-F-R-Y-L-D-S-V-S-H-R-P-G-K-G-P-G-R-Y-P-V-K-A-A-K-V-F-I-D-L-L-S-N-V-E-N-N-A-E-F-K-G-M-N-T-D-S-L-I-I-K-H-V-A-A-N-K-G-R-M-I-K-K-Y-T-P-K-A-Y-G-R-A-G-A-N-F-K-D-L-I-N-L-E-V-I-V-T-E-G-D-Q


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-V-V-N-K-Q-G-S-V-K-S-I-K-R-K-A-R-K-S-R-K-V-T-T-G-R-A-K-E-F-S-Y-K-G-Y-T-L-E-Q-L-Q-E-M-S-L-E-E-L-I-K-I-L-P-A-R-A-R-R-S-L-S-R-E-M-N-H-D-Q-K-K-L-V-E-K-L-E-G-D-Y-D-D-I-K-T-H-V-R-D-V-I-I-L-P-S-Y-V-G-K-I-V-E-V-Y-N-G-N-S-Y-S-K-F-E-I-K-P-E-M-I-G-H-Y-L-G-E-F-V-M-T-R-K-E-V-K-H-S-G-P-G-V-G-A-T-R-S-S-K-F-M-P-L-K


### FUNCTION Binds to 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome ### SEQUENCE -M-G-D-V-I-L-S-P-V-S-T-E-K-T-A-L-L-A-E-K-E-N-K-L-T-L-I-V-D-R-K-A-T-K-E-D-I-K-R-E-V-E-S-R-F-S-V-K-V-E-G-I-N-I-L-I-T-K-K-G-K-K-A-I-V-K-L-A-K-E-Y-S-A-E-E-I-A-E-R-I-G-V-F


### FUNCTION Involved in protein export The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex ### SEQUENCE -M-A-S-D-K-K-S-E-G-F-Q-S-G-A-G-L-I-R-Y-F-E-E-E-E-I-K-G-P-A-L-D-P-K-L-V-V-Y-I-G-I-A-V-A-I-M-V-E-L-A-K-I-F-W-P-P


### FUNCTION The glycine cleavage system catalyzes the degradation of glycine The H protein shuttles the methylamine group of glycine from the P protein to the T protein ### SEQUENCE -M-T-N-V-P-D-G-L-K-Y-T-K-T-H-E-W-Y-K-V-D-N-G-I-A-T-V-G-I-T-D-Y-A-Q-S-Q-M-T-D-I-V-Y-V-D-L-P-E-V-G-D-K-K-K-V-G-D-V-L-L-T-I-E-S-V-K-S-A-E-D-V-Y-S-P-L-T-G-E-I-T-E-V-N-Q-E-L-T-K-H-P-E-N-I-N-K-D-P-Y-G-N-W-L-V-K-M-K-V-E-K-E-G-E-Y-L-T-A-E-Q-Y-R-K-L-I-Q


### FUNCTION The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis ### SEQUENCE -M-V-V-K-L-V-V-A-V-R-K-D-L-D-M-G-K-G-K-I-A-A-Q-V-A-H-A-A-V-S-C-A-I-K-A-M-K-E-K-K-K-I-F-D-E-W-M-D-E-G-Q-K-K-I-V-V-K-V-P-N-V-D-E-I-Y-I-I-K-K-K-A-D-S-M-G-I-I-N-E-V-I-Q-D-R-G-Y-T-Q-V-E-P-G-T-V-T-C-I-G-L-G-P-D-Y-E-V-Y-L-D-D-I-T-G-K-Y-K-L-L


### FUNCTION Catalyzes the formation of CDP-2,3-bis- and CTP This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids ### SEQUENCE -M-N-Y-P-L-L-M-A-Q-A-I-I-L-F-V-P-A-L-I-A-N-S-G-A-V-L-T-G-G-Y-F-V-L-D-R-G-K-N-F-I-D-G-R-R-I-L-G-D-G-K-T-L-S-G-Y-L-G-G-S-F-I-G-I-V-S-G-V-I-I-Y-W-I-S-Y-A-T-H-F-I-L-G-N-Y-G-S-I-A-L-S-I-E-I-P-A-V-M-A-F-G-S-L-T-G-D-I-L-G-S-F-V-K-R-R-I-G-I-K-S-G-G-K-G-G-L-L-D-Q-W-P-F-A-L-V-A-F-L-F-L-F-L-M-E-R-P-F-F-L-H-Y-Y-F-F-A-G-I-I-V-I-L-A-I-V-P-P-L-H-R-A-V-N-I-I-G-Y-K-L-H-K-K-D-V-P-W


### FUNCTION With S4 and S5 plays an important role in translational accuracy Located at the interface of the 30S and 50S subunits ### SEQUENCE -M-G-N-G-L-N-A-G-R-K-L-L-E-N-R-K-K-F-R-W-S-D-R-D-Y-K-R-R-V-L-Q-L-K-R-K-S-D-P-L-E-G-A-P-Q-A-K-G-I-A-I-E-K-V-G-I-E-A-K-Q-P-N-S-A-I-R-K-C-V-K-V-Q-L-I-K-N-G-R-Q-I-T-A-F-A-V-G-D-G-A-I-N-Y-I-D-E-H-D-E-V-T-V-E-G-I-G-G-R-M-G-R-S-K-G-D-I-P-G-V-R-Y-K-V-V-A-V-N-G-I-S-L-K-E-L-V-K-G-R-K-E-K-T-V-R


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit Is located at the subunit interface close to the decoding center ### SEQUENCE -M-L-F-D-K-Y-D-V-N-S-V-E-V-H-D-P-G-M-V-K-Y-I-N-V-K-S-A-L-N-L-H-T-G-G-R-F-S-S-Y-Y-A-G-K-I-N-M-N-V-V-E-R-L-I-N-K-L-M-R-T-E-K-W-T-G-K-K-Y-S-A-Y-K-I-T-K-D-A-F-D-I-I-A-D-K-T-K-Q-N-P-L-Q-I-L-I-N-A-I-E-N-A-G-P-R-E-E-V-T-R-L-K-Y-G-G-I-A-V-P-K-S-V-D-V-S-P-S-R-R-V-D-E-A-L-R-N-I-A-T-G-A-T-N-A-S-F-K-S-K-K-S-I-V-N-C-L-A-D-E-I-M-L-A-A-K-N-D-A-S-S-F-A-I-S-K-K-E-E-I-E-R-V-A-Q-S-A-R


### FUNCTION Contacts the emerging nascent chain on the ribosome ### SEQUENCE -M-I-P-G-R-M-N-S-R-E-M-R-R-L-M-A-Q-M-G-I-K-S-T-E-M-D-D-V-K-K-V-I-F-V-G-K-E-K-D-Y-V-I-E-N-A-Q-V-T-M-I-E-A-Q-G-V-K-T-F-Q-V-V-G-D-F-R-E-T-P-K-K-Q-E-G-K-K-E-E-T-F-P-E-D-D-I-K-L-V-M-D-Q-T-G-V-A-R-E-K-A-I-E-A-L-K-A-A-S-G-E-P-A-Q-A-I-L-N-L-T-Q-K


### FUNCTION Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in Mjannaschii 16S rRNA It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3- ### SEQUENCE -M-T-G-I-Y-Y-L-Y-L-R-Q-D-D-P-K-K-A-T-M-R-K-L-E-R-F-G-L-A-K-R-V-D-I-K-G-V-G-L-K-L-V-L-T-P-Y-A-D-I-F-L-S-R-E-D-A-V-L-Y-E-K-Y-G-L-C-V-I-E-G-S-W-N-K-I-D-S-I-K-S-L-K-F-R-I-E-R-R-L-P-A-L-L-A-A-N-P-V-N-Y-G-K-I-G-I-L-S-S-V-E-A-T-A-A-A-L-Y-I-I-G-Y-W-D-T-A-Y-A-L-L-S-K-F-S-W-G-L-N-F-I-K-L-N-E-N-P-L-N-E-Y-S-T-A-D-R-S-E-I-K-K-I-E-E-S-Y-F-G


### FUNCTION Produces ATP from ADP in the presence of a proton gradient across the membrane ### SEQUENCE -M-Q-S-C-I-T-V-I-G-E-R-D-V-V-L-G-F-R-L-L-G-I-T-N-T-I-V-A-E-G-K-D-L-V-K-K-F-M-E-E-F-E-N-P-H-C-S-V-I-V-V-S-E-H-L-K-N-M-I-D-K-K-T-L-R-S-I-E-V-S-S-K-P-L-V-V-F-I-P-L-P-G-F-K-E-E-E-S-I-E-T-M-A-K-R-I-L-G-I-D-I-G-S-V


### FUNCTION Produces ATP from ADP in the presence of a proton gradient across the membrane ### SEQUENCE -M-S-L-E-Q-V-I-K-E-I-E-Q-S-Q-E-I-K-K-K-E-I-L-E-N-T-K-N-I-L-D-K-M-E-A-E-K-K-A-K-I-D-E-I-R-A-L-Y-Q-E-K-M-R-A-E-S-S-R-I-T-A-S-I-I-D-K-A-N-I-E-A-R-S-I-L-R-N-K-I-E-E-I-L-E-G-Y-V-S-A-A-Q-E-I-L-R-N-I-R-N-M-P-E-Y-P-A-L-L-N-K-M-I-E-V-A-K-K-Y-L-G-Q-D-C-I-I-K-V-D-S-K-D-K-A-V-A-P-S-S-G-I-T-Y-S-N-I-D-P-Y-G-G-I-L-A-S-S-R-D-G-K-V-E-L-D-L-R-V-S-S-I-M-E-E-V-L-E-K-I-K-V-K-I-Y-T-R-L-E-E


### FUNCTION Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate ### SEQUENCE -M-L-S-E-D-L-V-K-S-G-A-I-K-F-G-D-F-I-L-T-S-G-K-R-S-D-Y-Y-V-D-I-K-E-A-A-T-D-P-N-L-L-S-E-I-A-S-E-F-S-K-M-I-H-A-R-K-I-A-G-M-E-L-G-A-V-P-L-I-V-A-T-S-L-N-M-G-I-P-Y-V-I-V-R-K-E-R-S-H-G-T-L-S-L-I-V-G-R-L-N-R-G-E-E-V-D-V-I-E-D-V-V-T-T-G-N-S-V-L-K-A-I-N-V-L-R-E-N-G-V-V-V-K-D-A-Y-C-V-V-D-R-E-E-G-G-A-K-L-L-E-N-N-G-I-K-L-H-P-I-V-R-I-S-E-L-K-R


### FUNCTION May be involved in maturation of the 30S ribosomal subunit ### SEQUENCE -M-V-S-V-K-Y-V-P-S-D-M-L-I-N-Y-V-S-G-K-L-K-E-E-K-K-I-K-E-P-N-W-V-K-F-V-K-T-G-V-S-K-E-K-P-P-L-Q-D-D-W-I-Y-V-R-A-A-S-M-L-R-K-L-Y-I-N-G-Y-L-G-I-S-R-M-S-S-E-Y-G-G-K-V-D-R-G-S-K-R-Y-H-A-A-S-G-S-R-S-I-T-R-F-L-F-H-E-L-E-S-A-G-L-V-Q-K-T-Q-K-G-R-S-L-S-P-Q-G-M-S-L-L-D-N-A-S-K-E-I-I-K-Q-L-A-Q-K-D-P-L-Y-E-K-F-I


### FUNCTION RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus It can also cleave other RNA substrates such as 45S RNA The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme ### SEQUENCE -M-K-E-N-R-I-R-K-N-A-E-F-R-R-V-Y-R-K-G-K-S-F-S-N-R-L-L-V-L-Y-V-Y-K-N-Y-I-L-K-D-I-N-R-I-G-I-S-V-S-K-K-V-G-K-S-V-V-R-S-R-V-K-R-L-I-G-E-S-Y-R-L-N-S-S-N-L-K-K-G-H-D-F-V-I-I-A-R-T-A-C-N-G-K-R-Y-S-D-I-E-D-S-I-K-N-L-F-N-K-A-G-L-V-I-Y-D-E-K-N-I-T


### FUNCTION Binds together with bS18 to 16S ribosomal RNA ### SEQUENCE -M-N-K-Y-E-T-L-F-I-L-N-P-S-L-D-E-E-G-I-N-T-N-V-E-K-F-K-S-V-I-T-N-G-G-G-E-V-E-N-V-D-L-W-G-K-R-K-L-A-Y-E-I-D-K-V-N-E-G-I-Y-V-L-V-N-F-Q-S-D-A-Q-L-P-K-E-L-D-R-V-F-R-I-S-D-S-I-I-R-H-L-I-I-S-L-E-K


### FUNCTION Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit ### SEQUENCE -M-A-R-D-N-G-N-K-D-R-D-G-K-R-P-N-G-G-R-N-R-K-M-K-R-K-I-C-S-F-C-M-E-K-S-E-S-I-D-Y-K-D-I-N-K-L-R-K-Y-V-T-E-R-G-K-I-L-P-R-R-I-S-G-N-C-A-K-H-Q-R-E-L-T-I-A-I-K-R-A-R-N-I-A-L-L-P-F-T-T-E


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-K-V-I-L-L-K-D-I-K-S-V-G-K-K-G-E-V-I-N-V-S-D-G-Y-A-R-N-F-L-F-P-R-K-L-A-E-E-A-N-N-S-N-M-R-V-L-N-L-K-K-D-A-E-R-K-Q-K-L-Q-E-T-E-E-A-Q-K-L-A-N-E-L-K-G-K-V-L-K-L-S-A-K-A-G-E-N-G-R-L-F-G-A-I-T-S-K-D-I-A-A-E-I-K-K-Q-F-N-V-D-I-D-K-K-K-V-N-S-E-T-I-R-K-L-G-N-Y-E-I-E-L-K-L-Y-P-E-I-S-T-K-I-N-V-L-I-S-E-G


### FUNCTION Probably involved in tryptophan uptake ### SEQUENCE -M-R-M-N-L-K-K-L-I-I-N-S-L-F-L-A-V-G-V-V-L-N-Q-I-T-P-P-I-L-F-G-M-K-P-D-F-S-L-A-M-L-F-I-I-I-L-L-N-D-D-Y-K-T-C-I-S-T-G-V-V-A-G-L-L-A-A-A-V-T-T-F-P-G-G-Q-L-P-N-I-I-D-R-I-V-T-T-S-L-V-F-I-A-L-R-P-F-K-D-K-I-N-D-K-I-H-M-I-I-T-T-I-V-G-T-I-I-S-G-S-V-F-L-G-S-A-L-I-I-V-G-L-P-A-S-F-K-A-L-F-I-T-V-V-L-P-A-T-I-I-N-A-I-V-G-T-I-I-F-V-A-V-K-K-S-M-R-V-V-F-R-Q


### FUNCTION Specifically methylates the pseudouridine at position 1915  in 23S rRNA ### SEQUENCE -M-N-I-T-L-I-T-V-G-K-L-K-E-K-Y-L-K-D-A-V-N-E-Y-A-K-R-L-Q-K-Y-C-K-L-N-I-I-E-L-Q-D-E-K-T-P-E-K-A-S-L-K-E-E-K-L-I-K-E-K-E-G-E-K-I-L-S-S-I-K-D-N-S-Y-V-V-S-M-D-L-K-G-K-M-F-S-S-E-E-F-S-A-F-I-D-D-L-G-V-R-G-N-S-S-I-D-F-V-I-G-G-S-L-G-L-S-D-A-V-L-A-R-A-N-Y-K-L-C-F-S-K-M-T-F-P-H-Q-L-F-R-V-M-L-L-E-Q-V-Y-R-A-F-R-I-S-R-G-E-P-Y-H-K


### FUNCTION Catalyzes the dephosphorylation of nucleotide monophosphates and of different sugar phosphates in vitro ### SEQUENCE -M-E-Q-L-N-I-C-I-D-I-D-G-T-I-T-D-A-Y-Y-W-I-D-L-C-N-S-Y-F-K-T-S-I-T-E-K-D-A-T-Q-Y-Y-I-H-K-I-L-N-V-P-L-E-E-Y-N-E-F-Y-E-K-Y-K-Y-K-L-H-S-E-Q-K-L-R-K-D-V-K-S-V-I-T-K-L-S-Q-N-N-N-I-F-F-V-T-A-R-E-R-D-L-T-I-L-T-Y-S-Y-L-R-K-K-E-I-P-Y-D-S-L-F-I-L-G-T-H-H-K-V-P-T-A-R-Q-L-N-C-D-L-F-I-E-D-N-Y-D-N-A-L-E-L-S-K-A-G-F-K-V-L-L-I-D-T-Y-Y-N-R-K-P-L-N-Q-N-I-I-R-F-Y-N-W-D-E-V-Y-G-I-V-D-R-L-F-E-K-S-E-A-I


### FUNCTION Could be involved in septation ### SEQUENCE -M-Q-I-T-D-V-R-I-R-K-I-T-S-E-G-K-M-K-A-I-V-S-V-T-F-D-N-E-F-V-V-H-D-I-K-V-I-E-G-Q-N-G-L-F-I-A-M-P-S-R-K-T-P-D-G-E-F-K-D-I-A-H-P-I-N-T-A-T-R-E-K-I-Q-S-A-I-L-A-E-Y-E-K-V-K-N-E-E-E-T-K-T-E-T-E-E


### FUNCTION The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis ### SEQUENCE -M-F-L-I-V-G-L-G-N-P-G-L-K-Y-E-H-T-R-H-N-M-G-F-D-A-I-E-N-I-A-A-K-H-N-I-S-I-D-K-K-G-F-K-G-L-Y-G-K-G-I-I-D-G-E-K-V-I-L-L-K-P-Y-T-Y-M-N-L-S-G-E-S-V-V-E-A-A-N-Y-Y-K-I-N-K-E-N-I-V-V-I-Y-D-D-I-S-L-D-V-G-K-I-R-I-R-T-K-G-S-A-G-G-H-N-G-I-K-N-I-V-L-H-L-S-S-E-E-F-P-R-V-K-V-G-V-G-E-P-T-E-N-L-V-N-Y-V-L-G-K-F-S-Q-D-E-R-K-K-I-E-E-V-L-N-I-V-T-E-A-V-E-C-M-V-V-D-G-V-Q-N-A-M-N-K-F-N-G-L-K-L


### FUNCTION Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus GreA releases sequences of 2 to 3 nucleotides ### SEQUENCE -M-S-Q-E-K-K-Y-V-I-T-Y-K-G-V-K-K-L-E-E-E-L-E-Y-L-K-T-T-K-R-K-E-I-T-E-K-I-K-V-A-L-S-F-G-D-L-S-E-N-S-E-Y-D-E-A-K-N-D-Q-A-F-V-E-G-R-I-A-Q-I-E-N-M-L-K-N-A-N-V-I-D-E-S-E-L-K-N-D-V-V-S-V-G-S-K-V-M-V-K-D-Y-Q-F-D-E-E-I-E-F-S-I-V-G-S-A-E-A-D-P-I-E-N-K-I-S-N-E-S-P-V-G-S-A-L-I-G-K-K-V-G-D-E-I-E-V-N-V-P-D-G-V-D-K-Y-K-I-L-A-I-K


### FUNCTION Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate ### SEQUENCE -M-K-V-N-G-D-V-L-K-Y-G-D-N-I-D-T-D-V-I-I-P-A-R-Y-L-N-T-S-V-P-E-E-L-A-K-H-C-M-E-D-L-D-V-D-F-L-K-K-L-K-T-G-D-I-V-V-G-G-R-N-F-G-C-G-S-S-R-E-H-A-P-I-C-I-K-A-A-G-V-S-C-V-I-A-K-S-F-A-R-I-F-Y-R-N-S-I-N-I-G-F-P-I-L-E-C-E-E-A-V-N-D-A-S-T-G-D-K-L-E-V-D-F-I-E-G-I-I-K-N-V-T-L-N-K-E-Y-K-A-Q-P-F-P-D-F-M-L-K-I-M-K-N-E-G-L-T-N-C-V-K-K-G-L-F


### FUNCTION Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors ### SEQUENCE -M-A-K-K-V-V-G-L-I-K-L-Q-L-P-A-G-K-A-T-P-A-P-P-V-G-P-A-L-G-Q-H-G-V-N-I-M-A-F-C-K-E-Y-N-A-K-T-A-N-Q-A-G-F-T-I-P-V-V-I-T-V-Y-Q-D-R-S-F-S-F-I-L-K-T-P-P-A-A-V-L-I-K-K-A-A-G-I-E-S-G-S-G-V-P-N-K-N-K-V-G-K-I-T-K-E-Q-V-K-E-I-A-Q-T-K-M-P-D-L-N-A-A-S-L-E-A-A-M-S-M-I-A-G-T-A-R-S-M-G-V-E-V-V-D


### FUNCTION Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors ### SEQUENCE -M-V-N-K-N-R-Q-L-K-E-Q-K-V-A-E-I-K-E-K-M-G-K-T-E-A-M-I-M-V-K-Y-Q-G-L-N-V-E-E-D-T-E-L-R-K-A-L-R-E-A-G-V-E-Y-R-V-Y-K-N-S-L-A-V-R-A-I-N-E-L-G-Y-E-G-I-A-Q-Y-L-E-G-P-I-A-I-A-M-S-Y-D-D-P-T-A-P-A-R-I-I-N-D-F-A-K-T-H-K-A-L-E-L-V-A-G-Y-V-Q-G-E-V-F-D-V-N-K-V-K-E-L-A-S-V-P-A-K-E-V-L-I-A-K-L-L-G-S-F-K-A-P-L-S-N-F-A-Y-L-L-S-A-I-K-D-K-K-E-A-E-E-Q-A


### FUNCTION Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors Is thus essential for accurate translation ### SEQUENCE -M-T-R-E-E-I-I-E-A-I-K-G-M-S-V-L-E-L-N-E-L-V-K-A-C-E-E-E-F-G-V-S-A-A-A-P-V-A-V-A-G-A-A-G-A-A-G-A-A-A-G-E-E-K-T-E-F-D-V-V-L-A-E-A-G-A-K-K-L-Q-V-I-K-V-V-R-E-L-T-G-L-G-L-K-D-A-K-A-L-V-D-G-A-P-K-T-I-K-E-G-V-A-K-E-E-A-E-S-M-K-A-K-I-E-E-A-G-G-K-V-E-L-K


### FUNCTION With S4 and S5 plays an important role in translational accuracy ### SEQUENCE -M-P-T-I-S-Q-L-V-R-K-G-R-K-T-L-A-A-K-S-T-A-P-A-L-K-E-C-P-Q-K-R-G-V-C-T-V-V-K-T-T-T-P-K-K-P-N-S-A-L-R-K-I-A-R-V-R-L-T-N-G-Y-E-V-T-A-Y-I-P-G-V-G-H-N-L-Q-E-H-S-V-V-L-I-R-G-G-R-V-K-D-L-P-G-V-R-Y-H-I-V-R-G-T-L-D-A-A-G-V-A-D-R-K-Q-A-R-S-K-Y-G-A-K-K-P-K-Q-K


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA ### SEQUENCE -M-P-R-K-G-H-I-A-K-R-D-V-L-P-D-P-L-Y-N-S-K-V-V-T-K-L-I-N-N-I-M-E-D-G-K-K-G-V-A-Q-K-I-C-Y-N-A-F-E-Y-L-K-E-K-T-G-K-E-P-M-E-V-F-E-A-A-M-N-N-V-M-P-L-L-E-V-K-A-R-R-I-G-G-A-T-Y-Q-V-P-I-E-V-R-P-E-R-R-Q-T-L-G-I-R-W-M-L-A-A-A-D-K-R-G-E-K-Y-M-H-L-K-L-A-G-E-L-L-D-A-S-N-N-T-G-A-A-V-K-K-R-E-D-T-H-K-M-A-E-A-N-K-A-F-A-H-Y-R-Y


### FUNCTION Involved in the binding of tRNA to the ribosomes ### SEQUENCE -M-A-K-Q-K-I-R-I-R-L-K-A-F-D-H-T-I-L-D-Q-S-A-E-K-I-V-E-T-A-K-T-T-G-A-K-V-A-G-P-V-P-L-P-T-E-K-D-V-V-T-I-L-R-S-P-H-K-Y-K-D-S-R-E-Q-F-E-I-R-T-H-K-R-L-I-D-I-I-S-P-S-P-K-T-V-D-A-L-M-R-L-D-L-P-A-G-V-D-I-E-I-K-L


### FUNCTION One of the early assembly proteins it binds 23S rRNA One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome Forms the main docking site for trigger factor binding to the ribosome ### SEQUENCE -M-Y-T-N-S-H-D-I-I-R-K-P-V-I-T-E-K-S-M-A-E-M-A-D-K-K-Y-T-F-I-V-D-P-H-A-N-K-V-Q-I-K-K-A-I-E-E-V-F-G-V-K-V-E-K-V-N-T-S-N-I-L-G-K-T-K-R-V-G-V-H-V-G-K-R-A-D-Y-K-K-A-I-V-K-L-T-E-D-S-K-A-I-E-F-F-E-G-M-Q


### FUNCTION Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA ### SEQUENCE -M-S-R-S-I-K-K-G-P-F-V-K-E-S-L-L-N-K-I-V-E-M-N-K-A-G-D-K-K-V-V-K-T-W-S-R-S-S-T-I-F-P-E-M-I-G-H-T-I-A-V-H-D-G-R-K-H-V-P-V-Y-I-S-E-D-M-V-G-H-K-L-G-E-F-V-L-T-R-T-F-R-G-H-G-N-T-E-K-T-T-S-V-K


### FUNCTION This protein binds specifically to 23S rRNA ### SEQUENCE -M-E-A-K-A-I-A-K-Y-V-R-M-S-P-M-K-V-K-I-V-L-D-L-I-R-G-K-N-V-N-E-A-F-A-I-L-Q-Y-T-P-K-D-A-A-V-V-I-N-K-V-L-K-S-A-V-A-N-A-E-N-N-F-N-L-D-G-N-R-L-Y-V-S-E-A-Y-A-G-Q-G-P-T-L-K-R-F-Q-P-H-A-Q-G-R-A-F-S-I-K-K-R-S-S-H-I-T-V-I-V-K-E-R-D


### FUNCTION Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs ### SEQUENCE -M-L-M-P-K-R-V-K-H-R-K-V-Q-R-G-R-M-K-G-K-A-T-R-G-N-F-I-A-Y-G-D-F-A-I-Q-A-T-E-C-A-W-I-T-S-N-Q-I-E-A-A-R-I-A-I-N-R-Y-V-K-R-G-G-K-L-W-I-K-I-F-P-D-K-P-V-T-Q-K-P-A-E-T-R-M-G-S-G-K-G-S-P-E-Y-W-V-A-V-V-K-P-G-R-V-L-F-E-M-S-D-V-T-E-E-Q-A-R-E-A-F-R-L-A-S-H-K-L-P-I-K-T-K-F-V-T-R-K-D-F-E-E-M-G-G-E-A-N-E-G


### FUNCTION One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA ### SEQUENCE -M-E-R-G-N-R-K-T-R-I-G-R-V-V-S-D-K-M-D-K-T-I-V-V-A-V-E-T-K-V-R-H-P-L-Y-G-K-T-V-N-K-T-T-K-F-K-A-H-D-E-K-N-E-A-K-L-N-D-R-V-Q-I-M-E-T-R-P-L-S-K-D-K-R-W-R-L-V-E-I-V-E-K-A-K


### FUNCTION Binds to 23S rRNA Forms part of two intersubunit bridges in the 70S ribosome ### SEQUENCE -M-I-Q-A-Q-T-M-L-K-V-A-D-N-S-G-A-K-E-I-M-C-V-R-V-L-G-G-S-K-R-K-W-G-N-I-G-D-I-I-V-A-S-V-K-S-A-T-P-G-G-V-V-K-K-G-E-V-V-K-A-V-V-V-R-S-A-K-G-L-R-R-A-D-G-S-Y-I-K-F-D-E-N-A-A-V-L-I-K-D-D-K-Q-P-R-G-T-R-I-F-G-P-V-A-R-E-L-R-D-K-D-F-N-K-I-L-S-L-A-P-E-V-L


### FUNCTION One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit ### SEQUENCE -M-A-N-K-I-H-V-R-K-Q-D-S-V-V-V-I-S-G-K-D-R-G-K-I-G-E-V-L-A-V-N-P-K-K-G-T-V-L-I-K-D-V-N-V-V-V-K-H-Q-K-A-N-K-E-N-M-Q-G-G-L-I-K-K-E-A-P-I-N-S-A-K-V-M-L-Y-C-T-K-C-K-T-A-T-R-I-S-K-K-V-L-D-D-G-T-K-V-R-V-C-K-K-C-G-E-T-F


### FUNCTION This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance In the 70S ribosome it contacts protein S13 of the 30S subunit , connecting the 2 subunits ### SEQUENCE -M-V-P-R-L-K-E-K-Y-E-K-E-V-I-P-A-L-M-E-K-F-Q-Y-K-N-I-M-E-V-P-K-L-E-K-I-V-I-N-M-G-V-G-E-A-K-E-N-Q-K-V-L-E-S-A-V-A-D-M-Q-L-I-S-G-Q-K-P-I-L-T-R-A-K-K-S-V-A-N-F-K-I-R-E-N-M-P-I-G-C-K-V-T-L-R-K-N-K-M-F-E-F-A-D-K-L-M-N-V-A-L-P-R-V-R-D-F-R-G-V-S-S-K-S-F-D-G-R-G-N-Y-A-L-G-I-K-E-Q-L-I-F-P-E-V-E-Y-D-K-I-D-K-V-R-G-M-D-V-I-F-V-T-N-A-K-T-D-E-E-A-R-E-L-L-R-F-L-G-M-P-F-A-Q


### FUNCTION Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site ### SEQUENCE -M-A-R-K-A-L-I-E-K-W-K-K-E-P-K-Y-S-T-R-A-Y-T-R-C-K-I-C-G-R-P-H-S-V-L-K-K-Y-G-I-C-R-I-C-F-R-E-L-A-Y-K-G-E-I-P-G-C-R-K-A-S-W


### FUNCTION One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit ### SEQUENCE -M-V-M-T-D-P-I-A-D-L-L-T-R-I-R-N-A-N-V-V-R-H-G-V-V-E-L-P-S-S-K-I-K-K-A-M-A-N-I-L-L-Q-E-G-Y-L-K-D-I-E-E-Y-N-D-G-V-V-P-M-L-R-L-S-M-K-Y-G-K-G-K-E-R-I-V-T-G-L-K-R-I-S-K-P-G-L-R-V-Y-C-R-K-E-E-I-P-K-V-L-N-G-L-G-I-A-I-I-S-T-S-K-G-I-V-T-D-K-E-A-R-K-L-G-L-G-G-E-V-L-C-Y-V-W


### FUNCTION This protein binds to the 23S rRNA, and is important in its secondary structure It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center ### SEQUENCE -M-S-R-V-G-K-Q-P-V-E-I-P-S-G-V-T-V-T-V-T-P-D-N-V-V-T-V-K-G-T-K-G-Q-L-E-K-A-M-H-K-D-M-K-I-A-V-E-D-N-K-V-V-V-T-R-P-S-D-S-K-N-H-K-A-L-H-G-L-T-R-A-L-I-N-N-M-V-I-G-V-T-E-G-F-S-K-T-L-Q-L-V-G-V-G-Y-K-A-Q-L-K-G-K-S-L-I-L-N-L-G-Y-S-H-P-I-E-V-A-S-I-E-G-V-T-F-E-I-P-D-A-N-T-V-V-V-K-G-I-N-K-E-L-V-G-S-V-A-A-D-I-R-T-F-R-K-P-E-P-Y-K-G-K-G-I-K-Y-S-D-E-V-I-R-R-K-E-G-K-T-G-K


### FUNCTION This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance ### SEQUENCE -M-L-N-K-V-Q-S-R-K-R-R-H-L-R-V-R-N-K-I-S-G-T-P-E-R-P-R-L-A-V-Y-R-S-E-K-N-I-Y-A-Q-V-I-D-D-V-N-G-T-T-L-V-S-A-S-T-L-D-K-D-F-S-A-K-A-G-S-N-K-E-A-A-K-L-V-G-G-I-V-A-K-K-A-L-D-K-G-I-K-Q-V-V-F-D-R-G-G-Y-I-Y-H-G-R-I-K-E-L-A-E-A-A-R-E-A-G-L-E-F


### FUNCTION With S4 and S12 plays an important role in translational accuracy ### SEQUENCE -M-R-I-D-P-S-T-L-D-L-K-E-K-V-V-F-I-N-R-V-A-K-V-V-K-G-G-R-N-F-R-F-T-A-L-V-V-V-G-D-E-N-G-H-V-G-V-G-T-G-K-S-A-E-I-P-E-A-I-R-K-G-I-E-D-A-K-K-N-L-V-E-V-A-I-V-G-T-T-V-P-H-E-I-Y-G-E-F-G-T-G-R-V-L-I-M-P-A-S-E-G-T-G-V-I-A-G-G-P-V-R-A-V-L-E-L-A-G-L-N-D-V-R-A-K-S-L-G-S-N-N-P-R-N-M-V-N-A-T-I-N-G-L-S-R-L-R-T-V-E-Q-I-A-A-L-R-G-K-T-V-E-E-I-L-G


### FUNCTION Binds to the 23S rRNA ### SEQUENCE -M-K-L-H-E-L-K-P-A-A-G-S-R-K-A-P-K-R-V-G-R-G-T-G-S-G-L-G-R-N-A-G-K-G-E-K-G-Q-N-A-R-S-G-G-G-V-R-P-G-F-E-G-G-Q-M-P-L-Y-R-R-L-P-K-R-G-F-T-N-I-F-A-K-T-I-T-A-V-N-V-D-R-L-N-I-F-E-D-G-T-E-V-T-I-D-A-L-I-E-K-G-I-I-K-K-V-N-D-G-V-K-I-L-G-N-G-E-L-K-K-K-L-V-V-K-V-N-K-Y-S-K-S-A-A-E-K-I-E-A-A-G-G-K-A-E-V-I


### FUNCTION One of the essential components for the initiation of protein synthesis Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex ### SEQUENCE -M-S-K-E-D-V-I-E-M-Q-G-T-V-L-E-S-L-P-N-A-M-F-E-V-E-L-E-S-G-Q-K-I-L-A-H-I-S-G-K-L-R-M-N-F-I-R-I-L-P-G-D-K-V-T-V-E-L-S-P-Y-D-L-T-R-G-R-I-T-W-R-A-K


### FUNCTION Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA In the 70S ribosome it contacts the 23S rRNA , connecting the 2 subunits ### SEQUENCE -M-A-R-I-A-G-I-D-L-P-K-E-K-R-V-E-I-G-L-T-Y-I-Y-G-I-G-L-T-S-S-R-K-I-I-K-A-T-S-V-N-P-E-T-R-V-K-D-L-T-E-E-E-V-N-A-L-R-D-Y-I-N-K-N-F-K-I-E-G-D-L-R-R-E-V-A-L-N-I-K-R-L-V-E-I-G-C-Y-R-G-I-R-H-R-R-G-L-P-V-R-G-Q-K-T-K-T-N-A-R-T-R-K-G-P-K-K-A-V-A-S-K-K-K-K


### FUNCTION Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA Forms part of the Shine-Dalgarno cleft in the 70S ribosome ### SEQUENCE -M-A-V-Q-K-N-K-K-T-R-R-R-K-E-K-K-N-I-E-H-G-C-A-H-I-K-S-T-F-N-N-S-I-V-T-I-T-D-V-N-G-N-A-L-S-W-S-S-A-G-G-L-G-F-K-G-S-R-K-S-T-P-F-A-A-Q-M-A-A-E-T-A-A-K-T-A-M-E-H-G-L-K-S-V-D-V-F-V-K-G-P-G-S-G-R-E-A-A-I-R-S-L-Q-A-A-G-L-E-V-T-L-I-K-D-V-T-P-I-P-H-N-G-C-R-P-P-K-R-R-R-V


### FUNCTION This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself It is important during the early stages of 50S assembly ### SEQUENCE -M-K-S-Y-L-A-K-P-Q-E-I-E-R-K-W-Y-V-I-D-V-A-G-K-P-L-G-R-A-A-S-Q-I-A-S-I-L-R-G-K-N-K-P-I-Y-T-P-N-V-D-T-G-D-Y-V-I-V-L-N-A-E-K-V-L-L-T-G-K-K-A-D-Q-K-M-F-R-H-H-T-L-Y-P-G-G-L-K-E-M-S-Y-K-D-A-I-A-K-K-A-D-F-V-F-Y-E-A-V-R-R-M-L-P-S-G-V-L-G-R-K-M-I-K-K-L-K-V-Y-K-G-E-E-H-N-N-E-A-Q-K-P-E-V-L-E-L-K-Y


### FUNCTION Functions as the terminal component of an NADH peroxidase  as the electron transport intermediary from NADH to Rbr2 ### SEQUENCE -M-S-V-K-N-A-M-T-A-D-F-L-R-S-A-Y-G-G-E-S-M-A-H-M-R-Y-L-I-W-G-E-E-A-E-N-S-N-Y-P-N-I-G-R-L-F-K-A-I-A-Y-S-E-H-I-H-A-K-N-H-F-N-V-L-K-E-D-L-Y-D-S-S-V-V-A-G-A-V-F-G-S-T-N-L-I-D-N-L-Q-G-A-I-N-G-E-L-H-E-I-K-Q-M-Y-P-V-Y-L-E-T-A-R-Y-Q-E-E-K-E-A-E-R-T-F-H-Y-A-L-E-A-E-K-I-H-A-K-L-F-Q-D-A-Q-D-S-A-K-E-N-K-D-I-N-I-G-K-V-Y-I-C-P-V-C-G-F-T-T-L-D-E-N-I-E-Q-C-P-I-C-G-V-K-K-D-K-F-Q-A-F


### FUNCTION Allows the formation of correctly charged Asn-tRNA ### SEQUENCE -M-S-D-K-H-V-D-I-D-T-V-K-Y-I-S-K-L-S-K-L-K-F-T-D-N-E-A-K-K-L-A-G-E-F-E-A-I-L-G-H-F-E-T-I-D-K-V-D-L-S-D-I-N-V-N-E-F-D-E-V-N-T-E-F-R-K-D-V-P-K-V-F-E-D-K-K-K-L-M-Q-N-V-K-S-L-R-D-G-A-I-E-V-P-K-I-I-E


### FUNCTION Involved in the synthesis of autoinducer 2 ### SEQUENCE -M-E-K-I-A-S-F-T-V-N-H-L-T-L-Q-P-G-V-Y-V-S-R-K-D-K-F-G-D-V-V-I-T-T-F-D-I-R-M-T-S-P-N-E-E-P-V-M-N-T-A-E-V-H-T-I-E-H-L-G-A-T-F-L-R-N-H-G-T-Y-A-E-K-T-V-Y-F-G-P-M-G-C-R-T-G-F-Y-L-I-L-Q-G-D-Y-T-S-N-D-I-V-P-L-L-R-E-M-Y-K-F-I-A-D-F-K-G-E-V-P-G-A-A-A-R-D-C-G-N-Y-L-D-M-N-L-P-M-A-N-Y-W-G-K-K-F-S-A-L-L-D-N-I-S-E-D-R-L-N-Y-P-E


### FUNCTION Binds the 23S rRNA ### SEQUENCE -M-Q-K-D-I-Q-P-E-Y-H-Q-D-A-V-V-K-C-A-C-G-N-T-F-T-T-G-S-T-K-K-E-L-K-V-D-I-C-S-K-C-H-P-F-F-T-G-Q-Q-K-I-V-D-V-G-G-R-V-E-K-F-R-K-K-Y-N-L-S-A-D-K


### FUNCTION Involved in allosteric regulation of aspartate carbamoyltransferase ### SEQUENCE -M-L-T-I-N-S-I-K-N-G-I-V-I-D-H-I-K-A-G-H-G-I-K-I-Y-N-Y-L-K-L-G-E-A-E-F-P-T-A-L-I-M-N-A-I-S-K-K-N-K-A-K-D-I-I-K-I-E-N-V-M-D-L-D-L-A-V-L-G-F-L-D-P-N-I-T-V-N-I-I-E-D-E-K-I-R-Q-K-I-Q-L-K-L-P-S-E-V-N-N-I-I-K-C-S-N-P-R-C-V-T-S-V-E-S-Y-I-P-H-K-F-K-L-V-D-E-E-K-G-E-Y-K-C-E-Y-C-D-E-I-Y-K-G-A-K-A-L-E-I


### FUNCTION Necessary for normal cell division and for the maintenance of normal septation ### SEQUENCE -M-I-I-K-Q-A-E-F-I-I-S-A-A-W-K-K-Q-F-P-I-D-G-K-D-E-I-A-F-V-G-R-S-N-V-G-K-S-S-L-I-N-A-I-T-N-R-R-K-L-V-K-V-S-G-T-P-G-K-T-R-L-V-N-F-F-M-I-N-N-D-F-Y-F-V-D-L-P-G-Y-G-Y-A-K-V-S-K-K-E-L-E-K-W-S-Q-T-I-E-G-Y-L-V-G-R-E-Q-L-K-K-V-I-L-L-V-D-S-R-H-K-P-T-K-D-D-I-T-M-Y-N-W-I-K-Y-Y-D-Y-K-C-I-V-I-A-T-K-S-D-K-I-K-R-S-E-K-V-K-N-E-K-L-I-K-E-T-L-K-F-N-D-S-D-E-F-Y-F-F-S-S-A-T-K-Q-G-R-D-E-L-I-N-N-I-C-S-G-I-N-Y-S-E-N-S-L


### FUNCTION Removes the formyl group from the N-terminal Met of newly synthesized proteins Requires at least a dipeptide for an efficient rate of reaction N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions ### SEQUENCE -M-A-L-R-Q-I-R-L-S-E-D-E-I-L-R-K-K-S-R-P-V-E-V-V-D-D-K-I-R-Q-I-L-D-D-M-L-D-T-L-Q-N-T-E-N-G-A-A-I-A-A-P-Q-V-G-I-L-K-Q-L-V-V-I-A-T-G-E-D-I-I-K-L-V-N-P-K-I-V-K-K-E-G-E-Q-E-V-V-E-G-C-L-S-I-P-N-V-Y-G-K-L-K-R-P-K-K-V-T-V-E-A-L-N-E-N-G-E-K-I-T-L-T-G-E-G-F-L-A-K-C-F-C-H-E-I-D-H-L-D-G-I-L-F-T-D-L-V-T-E-Y-I-K


### FUNCTION IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins ### SEQUENCE -M-K-I-I-S-K-N-K-N-F-I-V-N-E-E-I-R-Q-K-E-V-R-V-I-G-D-D-G-S-Q-L-G-V-I-P-T-S-E-A-L-K-L-A-E-E-K-E-L-D-L-V-A-M-S-P-N-A-V-P-P-V-C-K-I-M-D-F-G-K-F-V-Y-E-Q-T-K-K-E-K-E-N-K-K-N-Q-K-I-V-N-V-K-E-V-R-L-S-A-S-I-E-E-H-D-V-Q-I-K-S-N-N-A-R-K-F-L-I-A-G-D-K-V-K-V-A-V-R-F-R-G-R-Q-T-D-Y-A-F-K-G-R-K-I-L-D-N-F-F-E-K-I-N-D-V-G-V-I-E-K-P-A-K-L-E-G-K-N-M-I-M-I-L-A-P-K-K-A


### FUNCTION Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit It is not involved in the protein synthesizing functions of that subunit ### SEQUENCE -M-A-R-V-K-R-A-V-N-A-R-K-N-H-R-K-V-L-K-L-A-K-G-Y-Y-G-G-K-S-K-L-F-K-T-A-N-E-S-V-I-R-A-L-R-N-A-Y-V-G-R-R-L-R-K-R-D-F-R-K-L-W-I-A-R-I-N-A-A-T-R-I-N-G-L-S-Y-S-K-F-I-N-G-I-K-L-A-G-I-D-M-N-R-K-M-L-S-E-I-A-I-N-D-P-K-A-F-S-E-L-V-E-V-A-K-K-Q-I-N-A


### FUNCTION Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis ### SEQUENCE -M-D-L-K-D-S-I-R-V-I-D-G-F-P-K-E-G-I-S-F-K-D-V-T-T-L-I-Q-D-K-E-A-Y-K-Y-S-V-D-K-I-G-E-Y-L-K-D-K-N-V-D-L-I-V-A-P-E-A-R-G-F-L-F-G-A-P-V-A-Y-K-I-G-A-G-F-I-P-V-R-K-K-G-K-L-P-C-E-T-V-E-V-T-Y-E-L-E-Y-G-E-D-I-L-E-M-H-K-D-A-I-K-K-G-Q-R-V-A-I-V-D-D-L-L-A-T-G-G-T-I-N-S-V-A-K-L-V-E-A-L-G-G-E-V-V-A-A-C-F-V-V-E-L-T-D-L-N-G-K-D-K-L-G-D-Y-D-T-M-S-L-V-K-Y-N-V


### FUNCTION Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors , playing an important role in chemotaxis ### SEQUENCE -M-E-E-R-E-N-I-K-E-I-R-V-G-I-A-D-L-N-T-A-F-S-P-N-R-I-I-T-V-G-L-G-S-C-I-G-I-A-I-Y-D-S-K-N-K-L-G-G-L-S-H-I-M-L-P-D-S-T-Q-F-S-K-V-T-N-P-Y-K-F-A-D-L-A-I-P-I-L-I-K-K-M-E-G-M-G-A-N-I-R-N-M-K-A-K-I-A-G-G-A-S-M-F-N-F-S-D-K-N-M-N-M-D-I-G-N-R-N-G-I-S-V-K-K-V-L-K-E-L-N-V-P-L-L-S-Q-D-I-G-G-N-K-G-R-T-M-I-F-N-T-L-D-G-S-V-D-I-R-T-V-G-M-G-I-R-K-I


### FUNCTION Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin Binds to flagellin and participates in the assembly of the flagellum ### SEQUENCE -M-K-L-E-T-Q-Y-H-G-I-I-E-Y-N-E-N-N-I-I-N-L-V-K-G-M-S-G-F-E-N-L-K-K-F-I-L-V-G-I-E-N-N-E-V-F-S-L-F-H-S-M-E-D-K-E-T-A-F-I-V-S-S-P-F-Y-V-K-A-D-Y-E-V-N-L-S-E-E-L-V-K-E-L-K-I-D-S-E-K-D-V-L-I-I-N-T-V-N-L-S-K-D-I-K-K-M-T-T-N-L-G-A-P-I-I-I-N-I-N-K-H-L-G-K-Q-I-I-I-S-D-D-E-K-M-I-K-Y-P-M-I-H-S


### FUNCTION A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW ### SEQUENCE -M-L-V-M-G-R-K-K-G-E-S-I-L-I-G-D-D-I-E-I-T-I-V-S-L-D-E-N-S-V-K-I-A-I-N-A-P-R-E-V-T-I-L-R-K-E-L-Y-N-K-I-K-E-E-N-K-E-A-V-I-K-S-S-E-V-L-K-E-L-T-L-K-K


### FUNCTION Cell division protein that is part of the divisome complex and is recruited early to the Z-ring Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments Its function overlaps with FtsA ### SEQUENCE -M-A-S-K-V-L-N-K-V-M-G-I-I-G-L-N-D-E-D-F-D-E-Y-E-D-E-V-M-E-E-K-A-I-A-R-E-N-S-Y-D-Y-D-E-K-L-N-D-K-N-S-S-N-S-N-N-K-V-V-N-I-H-T-A-S-S-V-K-V-V-I-V-K-P-K-D-Y-D-E-A-T-Q-I-C-D-D-L-K-N-R-K-I-V-V-V-N-V-T-D-L-E-P-K-T-A-Q-R-L-L-D-F-M-G-G-A-S-Y-V-L-N-G-E-L-L-E-I-D-K-G-V-Y-L-L-S-P-S-N-V-D-I-S-R-D-L-K-N-D-L-A-S-K-S-I-F-N-W-S-K


### FUNCTION Regulates transcriptional attenuation of the pyrimidine nucleotide  operon by binding in a uridine-dependent manner to specific sites on pyr mRNA This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes ### SEQUENCE -M-N-L-K-A-K-I-L-D-D-K-A-M-Q-R-T-L-T-R-I-A-H-E-I-I-E-K-N-K-G-I-D-D-I-V-L-V-G-I-K-R-R-G-V-P-I-A-D-R-I-A-D-I-I-E-E-I-E-G-S-K-V-K-L-G-K-V-D-I-T-L-Y-R-D-D-L-S-T-V-S-S-Q-P-I-V-K-D-E-E-V-Y-E-D-V-K-D-K-V-V-I-L-V-D-D-V-L-Y-T-G-R-T-C-R-A-A-I-E-A-I-M-H-R-G-R-P-K-M-I-Q-L-A-V-L-I-D-R-G-H-R-E-L-P-I-R-A-D-Y-V-G-K-N-V-P-T-S-K-S-E-L-I-S-V-N-V-K-G-I-D-E-E-D-S-V-N-I-Y-E-L