diff --git a/001/patient_clinical_data.json b/001/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..14644a6f69c0d5c96ec1343a69dc46bba6ef0e49 --- /dev/null +++ b/001/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/002/InvasionFront_CD3_block19_x1_y7_patient002_0.json b/002/InvasionFront_CD3_block19_x1_y7_patient002_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f33ce9d15f1d36b9310defe103008a282746b074 --- /dev/null +++ b/002/InvasionFront_CD3_block19_x1_y7_patient002_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4397.7, + "Centroid Y µm": 19239.8, + "Num Detections": 24709, + "Num Negative": 23303, + "Num Positive": 1406, + "Positive %": 5.69, + "Num Positive per mm^2": 556.86 + } +} \ No newline at end of file diff --git a/002/InvasionFront_CD3_block19_x2_y7_patient002_1.json b/002/InvasionFront_CD3_block19_x2_y7_patient002_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f87d3e46b4fa22075ce4e051686b875f0a0f8e81 --- /dev/null +++ b/002/InvasionFront_CD3_block19_x2_y7_patient002_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 19414.7, + "Num Detections": 18969, + "Num Negative": 18433, + "Num Positive": 536, + "Positive %": 2.826, + "Num Positive per mm^2": 241.86 + } +} \ No newline at end of file diff --git a/002/TumorCenter_CD3_block19_x1_y7_patient002_0.json b/002/TumorCenter_CD3_block19_x1_y7_patient002_0.json new file mode 100644 index 0000000000000000000000000000000000000000..98997947d55eb237406ccee935cb2b08258be698 --- /dev/null +++ b/002/TumorCenter_CD3_block19_x1_y7_patient002_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4997.4, + "Centroid Y µm": 19839.5, + "Num Detections": 21397, + "Num Negative": 19709, + "Num Positive": 1688, + "Positive %": 7.889, + "Num Positive per mm^2": 709.32 + } +} \ No newline at end of file diff --git a/002/TumorCenter_CD3_block19_x2_y7_patient002_1.json b/002/TumorCenter_CD3_block19_x2_y7_patient002_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9c7245d4a1613f0fa6f60b167a8fb73de5580b14 --- /dev/null +++ b/002/TumorCenter_CD3_block19_x2_y7_patient002_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7596.0, + "Centroid Y µm": 19514.7, + "Num Detections": 22153, + "Num Negative": 20462, + "Num Positive": 1691, + "Positive %": 7.633, + "Num Positive per mm^2": 668.52 + } +} \ No newline at end of file diff --git a/002/TumorCenter_CD8_block19_x2_y7_patient002_1.json b/002/TumorCenter_CD8_block19_x2_y7_patient002_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c63c533e0e65e649afa19708312903541a7fdbde --- /dev/null +++ b/002/TumorCenter_CD8_block19_x2_y7_patient002_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9045.2, + "Centroid Y µm": 28909.7, + "Num Detections": 23532, + "Num Negative": 22365, + "Num Positive": 1167, + "Positive %": 4.959, + "Num Positive per mm^2": 450.15 + } +} \ No newline at end of file diff --git a/102/InvasionFront_CD8_block20_x3_y6_patient102_0.json b/102/InvasionFront_CD8_block20_x3_y6_patient102_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d34add44d25534bed7dfbbfff833a5e687bf4a20 --- /dev/null +++ b/102/InvasionFront_CD8_block20_x3_y6_patient102_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11818.7, + "Centroid Y µm": 15241.9, + "Num Detections": 17409, + "Num Negative": 17165, + "Num Positive": 244, + "Positive %": 1.402, + "Num Positive per mm^2": 104.93 + } +} \ No newline at end of file diff --git a/102/TumorCenter_CD8_block20_x3_y6_patient102_0.json b/102/TumorCenter_CD8_block20_x3_y6_patient102_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e1f9eec2c4ab1c96535f4e7c490898db5e32589f --- /dev/null +++ b/102/TumorCenter_CD8_block20_x3_y6_patient102_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10894.2, + "Centroid Y µm": 14917.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/102/TumorCenter_CD8_block20_x4_y6_patient102_1.json b/102/TumorCenter_CD8_block20_x4_y6_patient102_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fb7cdec325f056cefae63f0505786c6dd4f2c394 --- /dev/null +++ b/102/TumorCenter_CD8_block20_x4_y6_patient102_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 14817.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/102/history_text.txt b/102/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/102/icd_codes.txt b/102/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15cdf3cedbb267117d620058bfef3b6f5d6fd43f --- /dev/null +++ b/102/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/102/ops_codes.txt b/102/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8df6f3265c48182789a4f7be4d28127cd025765c --- /dev/null +++ b/102/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Ösophagomyotomie pharyngozervikal sonstige[5-420.1x ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/102/patient_clinical_data.json b/102/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..55dac27088bc3c66cd2700316365bf560212dabc --- /dev/null +++ b/102/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/102/patient_pathological_data.json b/102/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..38275f6b1ab2c55473aa7b8c6132fce326e19b55 --- /dev/null +++ b/102/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "102", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/102/surgery_description.txt b/102/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..114edae4ef68ba8146753911a6f976accc6ad479 --- /dev/null +++ b/102/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, and Tracheotomy with Voice Prosthesis diff --git a/102/surgery_report.txt b/102/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2aedc4f52edeb6d742d6ff9b95399170bed61913 --- /dev/null +++ b/102/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation via the tracheostoma by the anesthetist. Then injection of Ultracaine. Entry with the small bore tube and inspection of the hypopharynx. There are no abnormalities here, the postcricoid region and both piriform sinuses are unremarkable. Then attempt to adjust the larynx. This is only possible with the smallest tube. The tumor has completely taken over the glottic plane and the glottis so that no lumen is visible. Then sterile washing and covering. Form an apron flap in the usual manner, integrating the tracheostoma. Suturing of the skin flap. Start with the neck dissection on the right side. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Exposure of the cervical vascular sheath with free preparation of the internal jugular vein. Exposure of the accessorius nerve. Clearing of levels II to V while sparing the plexus branches and the hypoglossal nerve and facial vein. Then turn to the opposite side. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Exposure of the nervus accessorius, the cervical vascular sheath and free preparation of the internal jugular vein. Clearing of levels II to V while sparing the plexus branches. Exposure of the hypoglossus and facial vein. Clearing of the medial neck block. Level VI was divided in the middle and added to the neck preparations on each side. Then dissection of the cervical vascular sheath from the larynx on both sides. Dissection of the thyroid gland from the larynx on both sides. Ligation of the upper laryngeal bundle on both sides. Exposure of the hyoid bone. Removal of the hyoid bone. Skeletonization of the larynx so that in the anterior region .............. Release of the piriform sinus on both sides. Then enter the mouth with the large Langenbeck spatula and lift the base of the tongue. Perform the pharyngotomy at this point. Pull out the epiglottis and open the pharynx along the epiglottis. This is very easy on the right side, on the left side the tumor appears to have grown into the medial area of the piriform sinus, so the mucosa must be removed more generously here. The entire larynx is detached so that it is only attached to the trachea and the cricoid cartilage. The larynx is removed below the cricoid cartilage and sent for a frozen section. The pathologist can no longer detect any tumor in the edges of the incision and the specimen is therefore resected in sano in the frozen section. Then transition to insertion of a Provox prosthesis. Entry with the trocar and creation of a tracheoesophageal fistula and insertion of a size 10 Provox prosthesis using the pull-through method. Then perform a posteromedial esophagomyotomy on the left side. Perform a myotomy on the sternocleidomastoid muscle to flatten the tracheostoma. Performing the pharyngeal suture with single button sutures. Perform another pharyngeal suture over the first pharyngeal suture, also with single button sutures. The constrictor pharyngeal muscle is then adapted as well as possible. This cannot be done in all places so that the pharynx does not narrow, but so that the largest part of the 3rd pharyngeal suture is still covered. Insertion of 2 Redon drainage tubes. Cut out the skin on the tracheostoma, as it is massively macerated by the previously placed tracheostoma. Then suture the skin to the trachea. Fold back the apron flap and complete the mucocutaneous anastomosis in the tracheal area and close the wound in two layers. Please do not feed orally postoperatively and carry out an X-ray gruel swallow after 10 days, then build up the diet when the pharyngeal suture is tight. \ No newline at end of file diff --git a/103/InvasionFront_CD3_block7_x1_y1_patient103_0.json b/103/InvasionFront_CD3_block7_x1_y1_patient103_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5acc530bbec68ed255d79fb225bea3bac6f56b1d --- /dev/null +++ b/103/InvasionFront_CD3_block7_x1_y1_patient103_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4422.7, + "Centroid Y µm": 2173.8, + "Num Detections": 22038, + "Num Negative": 21471, + "Num Positive": 567, + "Positive %": 2.573, + "Num Positive per mm^2": 238.79 + } +} \ No newline at end of file diff --git a/103/InvasionFront_CD3_block7_x2_y1_patient103_1.json b/103/InvasionFront_CD3_block7_x2_y1_patient103_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0d175981ccb0e302d50a1897899cfdb825fbe956 --- /dev/null +++ b/103/InvasionFront_CD3_block7_x2_y1_patient103_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7071.3, + "Centroid Y µm": 2223.8, + "Num Detections": 25016, + "Num Negative": 24892, + "Num Positive": 124, + "Positive %": 0.4957, + "Num Positive per mm^2": 51.24 + } +} \ No newline at end of file diff --git a/103/InvasionFront_CD8_block7_x1_y1_patient103_0.json b/103/InvasionFront_CD8_block7_x1_y1_patient103_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6fbf14ea0ca113bd406e4a2c663627bc9c169170 --- /dev/null +++ b/103/InvasionFront_CD8_block7_x1_y1_patient103_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6996.3, + "Centroid Y µm": 2448.7, + "Num Detections": 17081, + "Num Negative": 16763, + "Num Positive": 318, + "Positive %": 1.862, + "Num Positive per mm^2": 166.42 + } +} \ No newline at end of file diff --git a/103/InvasionFront_CD8_block7_x2_y1_patient103_1.json b/103/InvasionFront_CD8_block7_x2_y1_patient103_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b36382093bc9f36d96986df92f79904e865c735 --- /dev/null +++ b/103/InvasionFront_CD8_block7_x2_y1_patient103_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9594.9, + "Centroid Y µm": 2573.6, + "Num Detections": 20705, + "Num Negative": 20685, + "Num Positive": 20, + "Positive %": 0.0966, + "Num Positive per mm^2": 8.872 + } +} \ No newline at end of file diff --git a/103/TumorCenter_CD3_block7_x1_y1_patient103_0.json b/103/TumorCenter_CD3_block7_x1_y1_patient103_0.json new file mode 100644 index 0000000000000000000000000000000000000000..95243571b18872458764685c23808c91e652eef6 --- /dev/null +++ b/103/TumorCenter_CD3_block7_x1_y1_patient103_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4230.0, + "Centroid Y µm": 2576.7, + "Num Detections": 17664, + "Num Negative": 17607, + "Num Positive": 57, + "Positive %": 0.3227, + "Num Positive per mm^2": 26.23 + } +} \ No newline at end of file diff --git a/103/TumorCenter_CD3_block7_x2_y1_patient103_1.json b/103/TumorCenter_CD3_block7_x2_y1_patient103_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3ba83ac22bdf9d4c07b2cccc3f5543a906eaa9c5 --- /dev/null +++ b/103/TumorCenter_CD3_block7_x2_y1_patient103_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6796.4, + "Centroid Y µm": 2673.6, + "Num Detections": 18941, + "Num Negative": 18879, + "Num Positive": 62, + "Positive %": 0.3273, + "Num Positive per mm^2": 27.24 + } +} \ No newline at end of file diff --git a/103/TumorCenter_CD8_block7_x1_y1_patient103_0.json b/103/TumorCenter_CD8_block7_x1_y1_patient103_0.json new file mode 100644 index 0000000000000000000000000000000000000000..511283d2559d32ce7e89c0446d0716d5a6fe50e5 --- /dev/null +++ b/103/TumorCenter_CD8_block7_x1_y1_patient103_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4022.9, + "Centroid Y µm": 2773.5, + "Num Detections": 22818, + "Num Negative": 22795, + "Num Positive": 23, + "Positive %": 0.1008, + "Num Positive per mm^2": 10.19 + } +} \ No newline at end of file diff --git a/103/TumorCenter_CD8_block7_x2_y1_patient103_1.json b/103/TumorCenter_CD8_block7_x2_y1_patient103_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4ca362fd1381c36e04a562cf6960f898503f3797 --- /dev/null +++ b/103/TumorCenter_CD8_block7_x2_y1_patient103_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 2923.5, + "Num Detections": 25057, + "Num Negative": 25037, + "Num Positive": 20, + "Positive %": 0.0798, + "Num Positive per mm^2": 8.611 + } +} \ No newline at end of file diff --git a/103/history_text.txt b/103/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7a10ea34abfecd09de68eda6889cae3576a69812 --- /dev/null +++ b/103/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 cN0 oropharyngeal carcinoma on the left was histologically confirmed during a panendoscopy. The CT scan showed the tumor in direct contact with the internal carotid artery without any definite signs of infiltration. In addition, a subtotal thrombosis of the left internal jugular vein was found. Sonographic and computed tomographic findings of cN0 neck status without evidence of distant metastases. \ No newline at end of file diff --git a/103/icd_codes.txt b/103/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/103/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/103/ops_codes.txt b/103/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2f77eb5b4beccb982f4b75e4dbe8ca36707aba35 --- /dev/null +++ b/103/ops_codes.txt @@ -0,0 +1 @@ +Weichgaumenteilresektion[5-272.1 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Deckung mit freiem Radialis-Lappen Unterarm[5-858.73 L] Entnahme myokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.23 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhautdeckung großflächig Empfängerstelle Unterarm[5-902.68 L] Permanente Tracheotomie[5-312.0 ] Wechsel vaskuläres Implantat[5-394.3 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] \ No newline at end of file diff --git a/103/patient_clinical_data.json b/103/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a7d47007191865aa02574f367056b519945c11c8 --- /dev/null +++ b/103/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/103/patient_pathological_data.json b/103/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..371be72f34dab33d56c9f10d3b1a64d2e8d03aa2 --- /dev/null +++ b/103/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "103", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 51, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/103/surgery_description.txt b/103/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..64b1943c54fbb87620335a8c4ff84df908eeb36a --- /dev/null +++ b/103/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Defect coverage, Free flap (Radial), Neck dissection diff --git a/103/surgery_report.txt b/103/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d90c62d69f78af95c916d37f26078a041e53d902 --- /dev/null +++ b/103/surgery_report.txt @@ -0,0 +1 @@ +First, a pharyngoscopy is performed to determine the exact extent of the tumor: An exophytic mass is found on the left oropharyngeal side wall. Tumor growth begins at the posterior palatal arch with transition to the lateral pharyngeal wall and to approximately one third of the posterior pharyngeal wall. The tonsil and the anterior palatal arch are not infiltrated macroscopically and palpatorily. Growth over the posterior palatal arch up to the vicinity of the parauvular mucosal triangle. Overall moderate palpatory displacement. After positioning the patient, first transoral tumor resection: To obtain an overview and safe resection, enter the anterior palatal arch, taking the tonsil with you. Entering the anterior palatal arch. Release of the tonsil using the dissection technique. Behind the tonsil without direct contact, but according to ....................... the tumorous mass is now encountered. First cut around the mass on all sides with an electric knife. Resection up to the middle of the posterior pharyngeal wall. Problem-free loosening and resection of the tumor to the caudal and medial border. Complete removal of the posterior palatal arch. After loosening the edges in depth, careful dissection. However, a good displacement layer is now visible here, so that the tumor can be completely resected transorally macroscopically in sano. Circumscribed exposed fatty tissue from the neck, but no direct contact with the carotid artery as described in the CT scan. The tumor is now sent macroscopically in toto for frozen section diagnostics. If the resection in the area of the parauvular triangle on the posterior palatal arch is macroscopically scarce, a complete resection is performed here as well as a covering final margin sample, which is also sent for frozen section diagnostics. The tumor is now diagnosed in sano on all sides; only in the area of the caudal pharyngeal margin is there a clear alteration with questionable CIS. A new resection is therefore performed here, which is diagnosed as completely tumor-free in the frozen section diagnostics. Also basal free conditions. The deep wound bed is also resected later via pharyngotomy and placement of the vascular pedicle. After careful hemostasis, the neck is dissected on the left side: after injection of xylocaine with added adrenaline, the skin incision on the anterior edge of the sternocleidomastoid muscle is modified in a curved fashion. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Creation of a platysma flap. Exposure and careful preservation of the external jugular vein, which is very pronounced. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the superior thyroid artery and vein, the hypoglossal nerve and the cervical vein. Free preparation of the internal jugular vein. The vein shows clear wall changes, palpation with residual flow, no evidence of inflammatory changes, therefore the vein is left intact. Clear collateral formation with strong external jugular vein and anterior jugular vein. Exposure of the accessorius nerve. Clearing of the accessorius triangle and level V with careful protection of the cervical plexus branches. Overall macroscopically no suspicious nodes. Irrigation of the wound. Now turn to pharyngotomy. Resection of the digastric muscle, exposure of the stylohyoid. Exposure of the cervical vascular sheath and the external carotid artery. Preservation of the superior thyroid artery, the lingual artery, the facial artery and the occipital artery. Blunt perforation of the pharynx in the direction of the resection area. Widen the pharyngotomy until an approximately 3 ˝ finger-wide shaft is created. Basal co-resection of the wound bed. Neck dissection of the right side and radialis graft harvesting from the lower left side are now performed in parallel. Neck dissection on the right: In principle the same procedure as on the opposite side. Skin incision on the front edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Creation of a platysma flap. Exposure and preservation of the external jugular vein. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Clearing out the anterior neck preparation while carefully protecting the superior thyroid artery and the hypoglossal nerve. Exposure and protection of the accessorius nerve. Clearing out the accessorius triangle while carefully protecting the nerve. Completion of level V with careful protection of the cervical plexus branches. Final wound inspection. Wound irrigation. In dry wound conditions, without macroscopically suspicious nodes, insertion of a 10 Redon drain and careful, two-layer wound closure. Removal of the radialis graft from the left forearm: After marking a graft measuring 13 x 6 cm in total, using a skin monitor, the graft is cut into a bloodless area. Initially radial exposure and removal of the cephalic vein. Exposure and preservation of the superficial radial nerve ramus, which can remain completely intact. Expose the distal vascular pedicle. Dissection of the vascular pedicle. Strictly subfascial release of the graft. The ulnar artery lies deep and is not exposed. Strictly subfascial dissection of the graft with careful clipping of the outgoing muscle branches. Removal of the monitor bed. In the antecubital fossa it can now be seen that the cephalic vein remains relatively slender and does not form a visible bridge to the radial vein area. However, the radial veins unite to form a strong, common vessel, hence clipping of the cephalic vein, isolation also artery and vein. After reopening of the tourniquet, regular hand perfusion and excellent graft perfusion. Minutious hemostasis. Removal of the graft after regular blood flow. Subsequently, after wound inspection, careful, two-layered wound closure and insertion of the full-thickness skin graft lifted from the right groin. A vacuum sealing pump is then applied, the Kramer splint is placed in the functional position and the arm is repositioned. Full-thickness skin harvesting from the groin: For this purpose, cutting around an oval piece of skin measuring 15 x just under 6 cm, strictly cutaneous elevation, subcutaneous mobilization. Hemostasis and wound inspection. Placement of a 10 Redon drain and strong, two-layer wound closure under moderate tension. Now insertion of the graft combined transorally and transcervically. This is now considerably more difficult due to significant swelling in the throat and tongue area. Good fit, but extremely laborious insertion due to the local conditions and tight spaces. Finally, adequate suture intact on all sides. Positioning of the vascular pedicle and the cervical skin monitor. In the meantime, the tracheotomy was also performed due to the swelling conditions described: For this, with very deep lying cricoid cartilage, skin incision at the level of the cricoid cartilage. Cut through. Cut through the skin and subcutaneous tissue. Exposure and transection of the very strong anterior jugular vein. Ligation of the infrahyoid muscles that represent the veins. Dissection of the musculature. Exposure of the cricoid cartilage and the thyroid isthmus, which is coagulated if very thin. Very deep trachea, therefore insertion between the 1st and 2nd tracheal ring. Creation of a broad-based pedunculated Björk flap. Difficult incision with a low-lying trachea, but finally a wide tracheotomy and problem-free intubation onto an 8-gauge low-cuff cannula, which is suture-fixed. This is followed by cervical vascular preparation. This involves conditioning the flap vessels and the strong facial artery, which corresponds most closely to the strong radial artery. Carefully adapt the vascular suture with 8.0 Ethilon. Subsequently, regular flow conditions with immediate venous return and excellent graft perfusion, therefore now conditioning of the external jugular vein. If the flow is good, measure a size 3.5 coupler and perform the venous anastomosis with the coupler without any problems. Subsequently, regular blood flow with renewed excellent vitality of the graft and the skin monitor. Positioning of the skin monitor and insertion and careful, two-layer wound closure after insertion of a 10 Redon drain. Vital graft conditions at the end of the operation. Transfer of the patient intubated to the intensive care unit. Conclusion: Intraoperative R0-resected cT2 cN0 oropharyngeal carcinoma on the left. Laborious but sufficient reconstruction using a radialis graft. Due to the laborious intake conditions, the evaluation of the dietary reconstruction .............. Swallowing function should only be evaluated from the 9th to 10th postoperative day. Cannula supply, depending on swallowing function. Please strictly avoid cervical pressure dressings and exercise extreme caution when manipulating a venous anastomosis that is directly subcutaneous. \ No newline at end of file diff --git a/104/InvasionFront_CD3_block1_x1_y7_patient104_0.json b/104/InvasionFront_CD3_block1_x1_y7_patient104_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac9d7ff98a1c8b371ff1ae1098ab6df68348b8e5 --- /dev/null +++ b/104/InvasionFront_CD3_block1_x1_y7_patient104_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3947.9, + "Centroid Y µm": 18965.0, + "Num Detections": 18275, + "Num Negative": 17213, + "Num Positive": 1062, + "Positive %": 5.811, + "Num Positive per mm^2": 479.26 + } +} \ No newline at end of file diff --git a/104/InvasionFront_CD3_block1_x2_y7_patient104_1.json b/104/InvasionFront_CD3_block1_x2_y7_patient104_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4e3ea397ef61be117bcdd44ec31bc8febbe34023 --- /dev/null +++ b/104/InvasionFront_CD3_block1_x2_y7_patient104_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 19164.9, + "Num Detections": 22688, + "Num Negative": 20005, + "Num Positive": 2683, + "Positive %": 11.83, + "Num Positive per mm^2": 1075.3 + } +} \ No newline at end of file diff --git a/104/InvasionFront_CD8_block1_x1_y7_patient104_0.json b/104/InvasionFront_CD8_block1_x1_y7_patient104_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f1417d833d9e4a2fb40acb3efc876b43dce4dcc3 --- /dev/null +++ b/104/InvasionFront_CD8_block1_x1_y7_patient104_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 17515.7, + "Num Detections": 18396, + "Num Negative": 15806, + "Num Positive": 2590, + "Positive %": 14.08, + "Num Positive per mm^2": 1121.9 + } +} \ No newline at end of file diff --git a/104/InvasionFront_CD8_block1_x2_y7_patient104_1.json b/104/InvasionFront_CD8_block1_x2_y7_patient104_1.json new file mode 100644 index 0000000000000000000000000000000000000000..430322e67020d25f8d00c0afc7f366920d2fa264 --- /dev/null +++ b/104/InvasionFront_CD8_block1_x2_y7_patient104_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6621.5, + "Centroid Y µm": 17640.7, + "Num Detections": 21589, + "Num Negative": 17068, + "Num Positive": 4521, + "Positive %": 20.94, + "Num Positive per mm^2": 1834.7 + } +} \ No newline at end of file diff --git a/104/TumorCenter_CD3_block1_x1_y9_patient104_0.json b/104/TumorCenter_CD3_block1_x1_y9_patient104_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14001878720679375bbd48aa518f5b9f7463cbb5 --- /dev/null +++ b/104/TumorCenter_CD3_block1_x1_y9_patient104_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3848.0, + "Centroid Y µm": 22713.0, + "Num Detections": 23780, + "Num Negative": 14205, + "Num Positive": 9575, + "Positive %": 40.26, + "Num Positive per mm^2": 3786.8 + } +} \ No newline at end of file diff --git a/104/TumorCenter_CD3_block1_x2_y9_patient104_1.json b/104/TumorCenter_CD3_block1_x2_y9_patient104_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9aefbec3252750d36472c8ce43b15f88ed4ae12a --- /dev/null +++ b/104/TumorCenter_CD3_block1_x2_y9_patient104_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 22588.0, + "Num Detections": 22376, + "Num Negative": 15447, + "Num Positive": 6929, + "Positive %": 30.97, + "Num Positive per mm^2": 2830.1 + } +} \ No newline at end of file diff --git a/104/TumorCenter_CD8_block1_x1_y7_patient104_0.json b/104/TumorCenter_CD8_block1_x1_y7_patient104_0.json new file mode 100644 index 0000000000000000000000000000000000000000..325f44584ee86eff561ff1140b33f9655aa3817c --- /dev/null +++ b/104/TumorCenter_CD8_block1_x1_y7_patient104_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 26236.1, + "Num Detections": 21642, + "Num Negative": 18685, + "Num Positive": 2957, + "Positive %": 13.66, + "Num Positive per mm^2": 1213.8 + } +} \ No newline at end of file diff --git a/104/TumorCenter_CD8_block1_x2_y7_patient104_1.json b/104/TumorCenter_CD8_block1_x2_y7_patient104_1.json new file mode 100644 index 0000000000000000000000000000000000000000..de9a420e8f5067fcdbf9aceabc4809e74618b383 --- /dev/null +++ b/104/TumorCenter_CD8_block1_x2_y7_patient104_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8970.3, + "Centroid Y µm": 26286.1, + "Num Detections": 21717, + "Num Negative": 18499, + "Num Positive": 3218, + "Positive %": 14.82, + "Num Positive per mm^2": 1349.8 + } +} \ No newline at end of file diff --git a/104/history_text.txt b/104/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/104/icd_codes.txt b/104/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b966eaa1e0747159c12be413738a63bc20181214 --- /dev/null +++ b/104/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] Neubildung bösartig sekundär und onA Lymphknoten Kopf Gesicht Hals[C77.0 R] \ No newline at end of file diff --git a/104/ops_codes.txt b/104/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..537c2776b836a0b176e95bb985cb798cd27bd237 --- /dev/null +++ b/104/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Lokale Exzision Wange[5-273.4 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Freier Lappen mit mikrovaskuläre Anastomose Haut und Unterhaut Empfängerstelle Hals[5-905.05 ] Gestielte regionale Lappenplastik mit Fernlappen am Hals[5-906.25 ] Spalthaut Entnahmestelle sonstige[5-901.0x R] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Temporäre Tracheotomie[5-311.0 ] Transfusion Erythrozytenkonzentrat 1 TE (Transfusionseinheit) bis unter 6 TE (Transfusionseinheiten)[8-800.c0 ] \ No newline at end of file diff --git a/104/patient_clinical_data.json b/104/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3ca96e520480a8d929bb3e9ba824e15b4ca387eb --- /dev/null +++ b/104/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 59, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/104/patient_pathological_data.json b/104/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e21ef71fd3958eb4b2e95ecac46dd34ceb7095a8 --- /dev/null +++ b/104/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "104", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN3", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/104/surgery_description.txt b/104/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..603f21899bfbf238f736fdd4380f2415ce3be5f9 --- /dev/null +++ b/104/surgery_description.txt @@ -0,0 +1 @@ +Resection, Bilateral neck dissection, Tracheotomy, Defect coverage, Free flap (Radial), Pectoralis Major flap diff --git a/104/surgery_report.txt b/104/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b943cba7796867271e81398fa5e9eaf4d72b3eb --- /dev/null +++ b/104/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues. Entry with the Kleinsasser tube and inspection of the pharynx and larynx area. In the pharynx, an extensive exophytic mass can be seen in the area of the oropharynx, in the area of the tonsil lobe, infiltrating the anterior and posterior palatal arch and parts of the soft palate. The other pharyngeal areas and the larynx are unremarkable. Sterile washing and draping. Start with neck dissection on the right and left side in parallel. Right side, start with . Skin incision so that the large cystic metastasis is cut around. A large area of skin must also be resected. Exposure of the sternocleidomastoid muscle in the caudal region. Exposure of the omohyoid muscle and exposure of the capsule of the mass. Dissection of the lower part of the internal jugular vein. Then take over by and further release of the mass. The mass must be pushed away from the carotid artery. This is achieved without any problems in the area of the common carotid artery. In the bulb area, it can be seen that the external carotid artery is infiltrated by the tumor. The internal jugular vein is then ligated and the mass removed, taking with it the sternocleidomastoid muscle with which the mass has grown together. The hypoglossal nerve is also infiltrated and must be severed as well as the accessorius nerve. The plexus branches of the cervical plexus can be preserved. The vagus nerve can also be preserved. Ultimately, the entire neck preparation with the metastasis is removed en bloc. Only the common carotid artery and internal carotid artery as well as the vagus nerve and the border cord remain. At the same time, perform the neck dissection on the left side through and . Neck dissection on the left: Skin incision, transection of the cutaneous and subcutaneous tissue and the platysma. Subplatysmal dissection and elevation of the apron flap. Suturing of the apron flap. Exposure of the anterior border of the sternocleidomastoid muscle and dissection along the muscle in depth until the cervical plexus is exposed. Identification of the omohyoid muscle and dissection along the muscle to the hyoid bone. Identification of the accessorius nerve and the digastric muscle. Dissection medially to the hyoid bone. Release of the submandibular gland, which is left in place during dissection. Identification of the hypoglossal nerve. This can be safely spared. Dissection along the vein from caudal to cranial and detachment of the neck preparation. Sending in levels II, III, IV and V in individual preparations. Irrigation with hydrogen and Ringer and completion of the neck dissection on the left side without complications. Insertion of the tonsil plug and inspection of the tumor region. Incision of the tumor region with a safety margin of at least 1 cm in the oropharynx using the electric needle. Dissection with the needle as well as with scissors and bipolar forceps. The preparation is obtained en bloc and is placed on cork for frozen section. In the frozen section, all margins and also basal R0. The tumor resection creates a defect towards the neck. The tumor itself had no contact with the large metastasis and was still separated from it by a thin layer of tissue. Now measurement of the defect and lifting of the radialis graft from the left forearm by . Lifting the radialis graft: Marking the graft on the distal forearm on the left side. S-shaped skin incision and proximal forearm. Exposure of the confluence and dissection of a superficial vein (cephalic vein) up to the radial flap edge. Incision along the marked skin incision down to the forearm fascia. Incision of the forearm fascia and subfascial preparation of the radialis graft. Care is taken to protect the external ramus of the radial nerve, particularly at the radial end. The ulnar artery can also be safely spared. Dissection of the distal section of the radial artery and ligation of the radial artery after prior control by clamping with a vascular clip. A good perfusion signal can be measured on the index finger during clamping. Then preparation of the radial artery graft from the depth under constant bipolar coagulation and placement of vessel clips on the perforator vessels. Dissection up to the crook of the elbow, reliable identification of the brachial artery, the ulnar artery and the interosseous artery. Separation of the radial artery after the exit of the interosseous artery. Separation of the veins and irrigation of the graft with heparin. Lift the split skin from the right thigh using and . Insertion of the graft from transcervical and transoral through . Creation of the arterial and venous anastomosis. Arterial to the superior thyroid artery, venous to the facial vein and a second vein. The anastomosis is located on the left side. The stalk was guided over the larynx to the left. Then skin suture in the area of the left side of the neck and a second graft must be lifted to close the right side of the neck. A pectoralis major graft was harvested from the right side for this purpose. To do this, cut around a skin island 8 x 4 cm medial to the nipple. Then dissect down to the thoracic wall. Lifting of the petoral muscle from the thoracic wall. Detachment of the attachment of the pecotralis muscle from the sternum and humerus. The pedicle is clearly identified. The graft is pulled through a tunnel representing the theoretical deltopectoral flap. The deltopectoral flap was not lifted off, but only tunneled under medially. Dissection of a skin flap in the neck area, which is folded back. Fitting of the pectoralis major graft. Adjustment of the folded back neck skin in the sense of a plastic reconstruction. Beforehand, insertion of a Redon drain and completion of the procedure without complications. After the tumor resection, a tracheotomy was performed between the second and third tracheal cartilage in the usual manner. Insertion of a tracheal cannula. Suturing of the tracheostomy tube. Continue antibiotics for at least 24 hours. Flap checks in the usual manner. Presentation at the tumor conference after receipt of the histology. X-ray pelvic swallow after 14 days. \ No newline at end of file diff --git a/105/InvasionFront_CD3_block15_x1_y10_patient105_0.json b/105/InvasionFront_CD3_block15_x1_y10_patient105_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6b505921dafa6080951707d90083e57f336e56d3 --- /dev/null +++ b/105/InvasionFront_CD3_block15_x1_y10_patient105_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 35556.2, + "Num Detections": 15209, + "Num Negative": 13700, + "Num Positive": 1509, + "Positive %": 9.922, + "Num Positive per mm^2": 849.5 + } +} \ No newline at end of file diff --git a/105/InvasionFront_CD3_block15_x2_y10_patient105_1.json b/105/InvasionFront_CD3_block15_x2_y10_patient105_1.json new file mode 100644 index 0000000000000000000000000000000000000000..411cf5c32a8dc7fb0b84b3a2b1649d8be3ee4ddf --- /dev/null +++ b/105/InvasionFront_CD3_block15_x2_y10_patient105_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9220.1, + "Centroid Y µm": 35481.2, + "Num Detections": 5221, + "Num Negative": 4974, + "Num Positive": 247, + "Positive %": 4.731, + "Num Positive per mm^2": 401.44 + } +} \ No newline at end of file diff --git a/105/InvasionFront_CD8_block15_x1_y10_patient105_0.json b/105/InvasionFront_CD8_block15_x1_y10_patient105_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d6768c4bb372ca24eed3e66a39059602348275f2 --- /dev/null +++ b/105/InvasionFront_CD8_block15_x1_y10_patient105_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4291.9, + "Centroid Y µm": 24799.2, + "Num Detections": 10879, + "Num Negative": 10277, + "Num Positive": 602, + "Positive %": 5.534, + "Num Positive per mm^2": 285.14 + } +} \ No newline at end of file diff --git a/105/InvasionFront_CD8_block15_x2_y10_patient105_1.json b/105/InvasionFront_CD8_block15_x2_y10_patient105_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f28389e7775e5aecee925bf8e8001710ceaf055 --- /dev/null +++ b/105/InvasionFront_CD8_block15_x2_y10_patient105_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6808.1, + "Centroid Y µm": 24701.9, + "Num Detections": 6289, + "Num Negative": 6212, + "Num Positive": 77, + "Positive %": 1.224, + "Num Positive per mm^2": 65.08 + } +} \ No newline at end of file diff --git a/105/TumorCenter_CD3_block15_x1_y10_patient105_0.json b/105/TumorCenter_CD3_block15_x1_y10_patient105_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a8b1ff0cb07b9e4e4c8cf3df08be3fb18a6b8630 --- /dev/null +++ b/105/TumorCenter_CD3_block15_x1_y10_patient105_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3823.0, + "Centroid Y µm": 28210.1, + "Num Detections": 19667, + "Num Negative": 18490, + "Num Positive": 1177, + "Positive %": 5.985, + "Num Positive per mm^2": 490.58 + } +} \ No newline at end of file diff --git a/105/TumorCenter_CD3_block15_x2_y10_patient105_1.json b/105/TumorCenter_CD3_block15_x2_y10_patient105_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4f684b345fc0624b49b26c3e06c29c4a8dcdb89e --- /dev/null +++ b/105/TumorCenter_CD3_block15_x2_y10_patient105_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 28260.0, + "Num Detections": 20753, + "Num Negative": 19664, + "Num Positive": 1089, + "Positive %": 5.247, + "Num Positive per mm^2": 456.51 + } +} \ No newline at end of file diff --git a/105/TumorCenter_CD8_block15_x1_y10_patient105_0.json b/105/TumorCenter_CD8_block15_x1_y10_patient105_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7b0d40ba8552294feadf86898431ab224c888808 --- /dev/null +++ b/105/TumorCenter_CD8_block15_x1_y10_patient105_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 24786.9, + "Num Detections": 19143, + "Num Negative": 18598, + "Num Positive": 545, + "Positive %": 2.847, + "Num Positive per mm^2": 229.7 + } +} \ No newline at end of file diff --git a/105/TumorCenter_CD8_block15_x2_y10_patient105_1.json b/105/TumorCenter_CD8_block15_x2_y10_patient105_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9f89b6f3ffb0aa6902c31ad606c2de7c479c1321 --- /dev/null +++ b/105/TumorCenter_CD8_block15_x2_y10_patient105_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8895.3, + "Centroid Y µm": 24836.8, + "Num Detections": 18901, + "Num Negative": 18430, + "Num Positive": 471, + "Positive %": 2.492, + "Num Positive per mm^2": 194.49 + } +} \ No newline at end of file diff --git a/105/history_text.txt b/105/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d1086a1d76ee4b20b61fec0c313120798bb57075 --- /dev/null +++ b/105/history_text.txt @@ -0,0 +1 @@ +On <2014>, a sample was taken externally from an unclear lesion on the right edge of the patient's tongue. This resulted in the diagnosis of squamous cell carcinoma. Hence the indication for the above procedure. \ No newline at end of file diff --git a/105/icd_codes.txt b/105/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/105/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/105/ops_codes.txt b/105/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bc4eedbc4d4c8b7f317a08889563fee064048121 --- /dev/null +++ b/105/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Elektrokoagulation Zungengewebe[5-250.30 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/105/patient_clinical_data.json b/105/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c2ffa8a0cc53de7df7f6be0a7ab1eb943ca1de88 --- /dev/null +++ b/105/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 40, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/105/patient_pathological_data.json b/105/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3b109deb2df0d6652b38f41ab912b627c7a689ed --- /dev/null +++ b/105/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "105", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/105/surgery_description.txt b/105/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ad4850b811f9c06baf5fc9c3d4a3c50ae5aace1 --- /dev/null +++ b/105/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy and Panendoscopy diff --git a/105/surgery_report.txt b/105/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6ef6453a9876d4c8c4544ec5fbb96e74ce702944 --- /dev/null +++ b/105/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, tracheoscopy by the surgeon. Trachea freely visible up to the bifurcation. Subsequent problem-free intubation by the anesthesia colleagues. Entry with the esophagoscope. Pre-viewing under constant air insufflation into the stomach. Inversion. Inspection of the gastric mucosa. Inconspicuous conditions here. Inspection of the esophageal mucosa during retraction. Here also inconspicuous conditions. Now enter with the Kleinsasser tube. Inspection of the piriform sinuses on both sides, the postcricoid region, the endolarynx, the vallecula and the epiglottis. Inconspicuous conditions here. Inspection of the base of the tongue. Also unremarkable here. Now insertion of a reinforced mouth guard. Tonguing of the tongue. The previously described lesion in the area of the right edge of the tongue measuring approx. 1 cm can now be seen. This tumor is now incised macroscopically far into the healthy tissue with the electric needle, paying particular attention to being far into the healthy tissue, especially in the area of the tumor depth. The specimen is thread-marked for final histology. In addition, marginal samples are taken superiorly, inferiorly and posteriorly. Careful bipolar hemostasis. Ultimately, no more evidence of bleeding. The procedure was therefore completed without complications. Conclusion: Overall resection of a T1 tongue margin carcinoma on the left. Further procedure after receipt of the final histology and in accordance with our interdisciplinary tumor conference. \ No newline at end of file diff --git a/106/InvasionFront_CD3_block8_x3_y6_patient106_0.json b/106/InvasionFront_CD3_block8_x3_y6_patient106_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4ab94786131d867e30fcbdd690d5e677375cfadd --- /dev/null +++ b/106/InvasionFront_CD3_block8_x3_y6_patient106_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 25236.6, + "Num Detections": 14209, + "Num Negative": 13545, + "Num Positive": 664, + "Positive %": 4.673, + "Num Positive per mm^2": 384.01 + } +} \ No newline at end of file diff --git a/106/InvasionFront_CD3_block8_x4_y6_patient106_1.json b/106/InvasionFront_CD3_block8_x4_y6_patient106_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e024c77abd538ec69e5081d3fd74354d673aa9d --- /dev/null +++ b/106/InvasionFront_CD3_block8_x4_y6_patient106_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 25211.7, + "Num Detections": 12393, + "Num Negative": 11611, + "Num Positive": 782, + "Positive %": 6.31, + "Num Positive per mm^2": 537.01 + } +} \ No newline at end of file diff --git a/106/InvasionFront_CD8_block8_x3_y6_patient106_0.json b/106/InvasionFront_CD8_block8_x3_y6_patient106_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0328f4c1c488a4988d8056f67ad66d15a6d14484 --- /dev/null +++ b/106/InvasionFront_CD8_block8_x3_y6_patient106_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11618.8, + "Centroid Y µm": 15216.9, + "Num Detections": 17740, + "Num Negative": 17087, + "Num Positive": 653, + "Positive %": 3.681, + "Num Positive per mm^2": 295.14 + } +} \ No newline at end of file diff --git a/106/InvasionFront_CD8_block8_x4_y6_patient106_1.json b/106/InvasionFront_CD8_block8_x4_y6_patient106_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fdde944cba1897427b0aaafef8b80b7da54f2371 --- /dev/null +++ b/106/InvasionFront_CD8_block8_x4_y6_patient106_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14192.5, + "Centroid Y µm": 15391.9, + "Num Detections": 13192, + "Num Negative": 12402, + "Num Positive": 790, + "Positive %": 5.988, + "Num Positive per mm^2": 495.82 + } +} \ No newline at end of file diff --git a/106/TumorCenter_CD3_block8_x3_y6_patient106_0.json b/106/TumorCenter_CD3_block8_x3_y6_patient106_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9ac1f7d2babd89678a9592954d573230b4ae3af1 --- /dev/null +++ b/106/TumorCenter_CD3_block8_x3_y6_patient106_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11918.7, + "Centroid Y µm": 15916.6, + "Num Detections": 15568, + "Num Negative": 14974, + "Num Positive": 594, + "Positive %": 3.816, + "Num Positive per mm^2": 287.73 + } +} \ No newline at end of file diff --git a/106/TumorCenter_CD3_block8_x4_y6_patient106_1.json b/106/TumorCenter_CD3_block8_x4_y6_patient106_1.json new file mode 100644 index 0000000000000000000000000000000000000000..54bcdfedf25357d8625af5c5a9d4abdf7fbb74fe --- /dev/null +++ b/106/TumorCenter_CD3_block8_x4_y6_patient106_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14417.4, + "Centroid Y µm": 15616.7, + "Num Detections": 16626, + "Num Negative": 15259, + "Num Positive": 1367, + "Positive %": 8.222, + "Num Positive per mm^2": 619.49 + } +} \ No newline at end of file diff --git a/106/TumorCenter_CD8_block8_x3_y6_patient106_0.json b/106/TumorCenter_CD8_block8_x3_y6_patient106_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9075e54fd0bd4a191b808c2a6b20f34f2a9ca73f --- /dev/null +++ b/106/TumorCenter_CD8_block8_x3_y6_patient106_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11693.8, + "Centroid Y µm": 15566.8, + "Num Detections": 18122, + "Num Negative": 17672, + "Num Positive": 450, + "Positive %": 2.483, + "Num Positive per mm^2": 211.57 + } +} \ No newline at end of file diff --git a/106/TumorCenter_CD8_block8_x4_y6_patient106_1.json b/106/TumorCenter_CD8_block8_x4_y6_patient106_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b1e1a78a6bab1a726cb7b05884c064c0b4072e7a --- /dev/null +++ b/106/TumorCenter_CD8_block8_x4_y6_patient106_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14392.4, + "Centroid Y µm": 15391.9, + "Num Detections": 20215, + "Num Negative": 19572, + "Num Positive": 643, + "Positive %": 3.181, + "Num Positive per mm^2": 280.8 + } +} \ No newline at end of file diff --git a/106/history_text.txt b/106/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/106/icd_codes.txt b/106/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/106/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/106/ops_codes.txt b/106/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4cfc41572be00d3ec9bf909849b940a8e4d82bca --- /dev/null +++ b/106/ops_codes.txt @@ -0,0 +1 @@ +Transplantation fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.53 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Resektion Tracheagewebe mit Anlegen eines Tracheostoma[5-314.12 ] Entnahme Vollhaut zur Transplantation Leisten- und Genitalregion[5-901.1c ] Lokale Exzision Pharynxgewebe[5-292.0 ] Anlage oder Wechsel System zur Vakuumversiegelung Sonstige[5-916.ax ] Kontinuierliche Sogbehandlung bei Vakuumversiegelung Bis 7 Tage[8-190.10 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] \ No newline at end of file diff --git a/106/patient_clinical_data.json b/106/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a40e837d40ef80e7605c725910c7c77dca966719 --- /dev/null +++ b/106/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 50, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/106/patient_pathological_data.json b/106/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..35722d8f5d10bb8ecabcaa9709f5107785c8e910 --- /dev/null +++ b/106/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "106", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/106/surgery_description.txt b/106/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..caac77ae90d0527360b17b2bf22a75d76493bea4 --- /dev/null +++ b/106/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Right neck dissection, Defect coverage, Free flap (Radial), Tracheostomy, MLE (Microlaryngoscopy and Endoscopy), Pharyngoscopy diff --git a/106/surgery_report.txt b/106/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..666d44dd1d78ef9fe91ce6d7509cbd3bb068d88a --- /dev/null +++ b/106/surgery_report.txt @@ -0,0 +1 @@ +After insertion of a mouth guard, endoscopy of the pharynx and larynx to re-evaluate the current findings. Extensive tumor growth is seen, covering the entire soft palate and extending to the alveolar ridge on the right. However, the bone is not infiltrated here. Furthermore, the tumor extends caudally to the lower tonsil pole on the lateral pharyngeal wall on the right and ventrally into the dorsal floor of the mouth. The tumor also extends straight into the base of the tongue. In the following, the tumor is gradually bypassed and resected with the monopolar and bipolar scissors with a safety margin of 1 1/2 cm. The entire soft palate, 1/3 of the right base of the tongue, the posterior and lateral pharyngeal wall on the right and the dorsal floor of the mouth on the right must be removed. The resection ends in the right cheek in depth down to the alveolar ridge, from which the tumor can be easily detached. There is no infiltration here. There is pronounced scar tissue in the depth after surgery and radiation. Maximum resection is performed here except for the internal carotid artery on the right side. The lingual artery is ligated. The findings are sent for histological assessment. This is followed by vascularization on the right: skin incision in the area of the old scar and visualization of the sternocleidomastoid anterior edge. Dissection is also considerably more difficult here due to the previous treatment. The tissue is heavily scarred. Nevertheless, the internal jugular vein and the carotid artery with the exit of the superior thyroid artery can be visualized. This is further dissected and identified as a suitable connecting vessel. The outlet of the lingual and facial arteries is then identified and ligated. Dorsal to this, the pharyngotomy is performed in the tonsil lumen. This creates a 3-finger wide access into the oral cavity. After exposing the vessels to be anastomized (a deep branch of the internal jugular vein is prepared for the vein), the radial artery flap is lifted from the left forearm. The previously measured defect measures 10 x 6 cm, so that the graft is marked accordingly from the left forearm and lifted in a typical manner with a skin monitor. A tourniquet (300 mm/Hg) is created and skin flaps are prepared. Cut subfascially to the brachioradialis muscle and dissect the lateral cephalic vein distally. Dissection of the distal section of the cephalic vein and now medial to this to locate the radial superficial ramus nerve. This can be exposed and spared. Further subfascial dissection, leaving the peritendineum on the tendon sheaths and exposing the vascular pedicle. Clamping and ligation of the vascular pedicle. Further dissection from ulna to radial and then from distal to proximal with clipping of the feeding and draining vessels. The stalk is always spared. Dissection from distal to proximal and exposure of the transition of the radial artery into the ulnar artery. Also exposing the transition from the deep to the superficial venous system up to the cubital vein. In each case, the venous arterial supply is stopped after opening the tourniquet and careful hemostasis. Both flap perfusion and perfusion of the distal hand are very good. Deposition of the graft and subsequent insertion of the graft from external to enoral via the pharyngotomy. The graft is carefully and completely sutured in place using single button sutures (SA plus 3/0). Cervically, the radial artery is anastomosed with the superior thyroid artery using single button sutures and the vein of the graft with the venous outlet from the internal jugular vein. A 3.0 mm coupler is used for the latter end-to-end anastomosis. The final check of the blood flow reveals an undisturbed flow, so that the skin monitor is now incorporated into the cervical skin with subsequent subcutaneous and skin sutures in a tension-free position of the anostomosis. The final Doppler signals are also very good. Parallel to the incorporation of the graft, removes a full-thickness skin graft from the right groin. The wound there is primarily closed with subcutaneous sutures and skin sutures. A drain is inserted. Sterile wound dressing. Now incorporation of the free skin graft into the lifting defect on the left forearm. Primary closure of the proximal part of the forearm and incorporation of the free skin into the distal lifting defect. This is performed by . Finally, incision of the full-thickness skin and application of a vacuum dressing. This should be left in place for 7 days. Vacuum sealing was performed under sterile conditions. Application of a Cramer splint and opening of the vacuum dressing. \ No newline at end of file diff --git a/107/InvasionFront_CD3_block2_x1_y5_patient107_0.json b/107/InvasionFront_CD3_block2_x1_y5_patient107_0.json new file mode 100644 index 0000000000000000000000000000000000000000..72718c18fdcc2f3868387c5e469956c5346e8482 --- /dev/null +++ b/107/InvasionFront_CD3_block2_x1_y5_patient107_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6446.6, + "Centroid Y µm": 25736.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/107/InvasionFront_CD3_block2_x2_y5_patient107_1.json b/107/InvasionFront_CD3_block2_x2_y5_patient107_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7eae639d8ac86886b859fd8dd47fcf5041af9e3a --- /dev/null +++ b/107/InvasionFront_CD3_block2_x2_y5_patient107_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9020.2, + "Centroid Y µm": 25811.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/107/InvasionFront_CD8_block2_x1_y5_patient107_0.json b/107/InvasionFront_CD8_block2_x1_y5_patient107_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e1d023c92faee9ddc195ccb297e0ad2fedd8edec --- /dev/null +++ b/107/InvasionFront_CD8_block2_x1_y5_patient107_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5247.2, + "Centroid Y µm": 13293.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/107/InvasionFront_CD8_block2_x2_y5_patient107_1.json b/107/InvasionFront_CD8_block2_x2_y5_patient107_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f394cec33588341d20c60c7d34808abed0bc9605 --- /dev/null +++ b/107/InvasionFront_CD8_block2_x2_y5_patient107_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7795.9, + "Centroid Y µm": 13367.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/107/TumorCenter_CD3_block2_x1_y5_patient107_0.json b/107/TumorCenter_CD3_block2_x1_y5_patient107_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0d65b2b951326a5388aec11ebbb85c8c24a79c97 --- /dev/null +++ b/107/TumorCenter_CD3_block2_x1_y5_patient107_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4272.7, + "Centroid Y µm": 11743.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/107/TumorCenter_CD3_block2_x2_y5_patient107_1.json b/107/TumorCenter_CD3_block2_x2_y5_patient107_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6b792ebf82df73bafb48b1fe27ebd2017e6b98ef --- /dev/null +++ b/107/TumorCenter_CD3_block2_x2_y5_patient107_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6796.4, + "Centroid Y µm": 11868.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/107/TumorCenter_CD8_block2_x1_y5_patient107_0.json b/107/TumorCenter_CD8_block2_x1_y5_patient107_0.json new file mode 100644 index 0000000000000000000000000000000000000000..521c254b03cdfdef597185eaa18bb430468c5a84 --- /dev/null +++ b/107/TumorCenter_CD8_block2_x1_y5_patient107_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5722.0, + "Centroid Y µm": 12368.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/107/TumorCenter_CD8_block2_x2_y5_patient107_1.json b/107/TumorCenter_CD8_block2_x2_y5_patient107_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5ae0a79bf36d86bcb3d1881b1a1d37c6202a533c --- /dev/null +++ b/107/TumorCenter_CD8_block2_x2_y5_patient107_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8420.5, + "Centroid Y µm": 12318.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/107/history_text.txt b/107/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/107/icd_codes.txt b/107/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..04526ac505c39ecdb23c6b53660daad44edf23ee --- /dev/null +++ b/107/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Sonstige näher bezeichnete Lokalisationen[D48.7 ] Rachenmandelkarzinom[C11.1 R] Leukoplakie Stimmlippe[J38.3 L] \ No newline at end of file diff --git a/107/ops_codes.txt b/107/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c3c22d344f30ea8bd6ac5975609d4b5cf9b8a6f6 --- /dev/null +++ b/107/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Transorale Tumortonsillektomie[5-281.2 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 R] Rekonstruktionen Pharynx durch Naht [nach Verletzung][5-294.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Stripping Stimmlippe mikrolaryngoskopisch[5-300.7 ] \ No newline at end of file diff --git a/107/patient_clinical_data.json b/107/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5ca14c2a93b1f85b880641df9f268ed343d975ab --- /dev/null +++ b/107/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/107/patient_pathological_data.json b/107/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..68037ba7ff3e38ddb1b6a7bc9fdb84603dfb67de --- /dev/null +++ b/107/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "107", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2a", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/107/surgery_description.txt b/107/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1d3abf18fe82774a9b2ffdc5d2432f7ba255d2d6 --- /dev/null +++ b/107/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, and PEG placement diff --git a/107/surgery_report.txt b/107/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3ec059614edd6ec222e6195918476c39c74b454e --- /dev/null +++ b/107/surgery_report.txt @@ -0,0 +1 @@ +Start with PEG insertion. Entering with the esophagogastroscope. Pre-viewing into the stomach. Inconspicuous conditions on all sides. Perform the PEG insertion with good diaphanoscopy using the thread pull-through method. This is successful without any problems. Entry with the small bore tube and inspection of the hypopharynx and larynx. In the laryngeal region, a whitish deposit can be seen on the anterior third of the left vocal fold, which extends to the anterior commissure. Advance the microscope and remove this deposit while protecting the vocal folds. Microlaryngoscopically, the deposit looks like a leukoplakia. There is no indication of a polyp. Then insertion of the retractor and inspection of the tonsil region. On the right side, a crater-shaped change can be seen at the lower pole of the tonsil. The tonsil itself is also rough. Start of tumor tonsillectomy with incision of the mucosa and exposure of the upper pole. Removal of the tonsil, taking some of the musculature from the tonsil bed and taking part of the base of the tongue with it. This guarantees a sufficient safety margin. The lateral border to the neck is still intact. The tonsil is suture-marked to the frozen section. Unfortunately, the previously biopsied squamous cell carcinoma can no longer be found in the frozen section, but the margins are definitely clear, i.e. definitely an R0 situation. After consultation with the pathology department, the squamous cell carcinoma is to be looked for more precisely in the final histology. Neck dissection performed in the meantime. Transverse skin incision for this. Separation of the platysma. Formation of a platysma flap. Then expose the sternocleidomastoid muscle, the omohyoid muscle and the submandibular gland. Then free preparation of the vein. Level II shows a very large metastasis, Level II b shows several smaller ones and Level III and IV also show enlarged, coarse lymph nodes. Removal of the neck specimen en bloc while sparing the plexus branches. The large metastasis in level II can be easily detached from the internal jugular vein, but its tip extends very far towards the border of the oropharynx, creating a very small, 0.5 x 0.5 cm fistula to the oropharynx. This fistula is sutured over several times and the stylohyoid muscle and the posterior belly of the digaster are sutured over it for safety. A tracheotomy is then performed. For this, a skin incision is made below the cricoid cartilage. Exposure of the musculature. Entering the linea alba. Pushing the muscles aside. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus. Exposure of the anterior wall of the trachea. Insertion between the 2nd and 3rd tracheal cartilage. Creation of a visor tracheotomy. Insertion of an 8-bore tracheal cannula. Suturing of the 8 mm tracheostomy tube. Then re-inspection of the oropharynx. The wound area is very large, so that the tracheostomy is definitely justified. Stitching over tissue in the potential fistula area. The operation was completed without complications. No oral food for 5 days please. If there are signs of fistula, open the neck. Insertion of a flap and irrigation so that the saliva can drain and then wait, as the fistula is really very small. \ No newline at end of file diff --git a/108/InvasionFront_CD3_block19_x3_y3_patient108_0.json b/108/InvasionFront_CD3_block19_x3_y3_patient108_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d14559f6533fc16ef1ebf611b74cb21f51bf315a --- /dev/null +++ b/108/InvasionFront_CD3_block19_x3_y3_patient108_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12562.3, + "Centroid Y µm": 9929.8, + "Num Detections": 10692, + "Num Negative": 10477, + "Num Positive": 215, + "Positive %": 2.011, + "Num Positive per mm^2": 190.32 + } +} \ No newline at end of file diff --git a/108/InvasionFront_CD3_block19_x4_y3_patient108_1.json b/108/InvasionFront_CD3_block19_x4_y3_patient108_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1d889214ecbeb6bcb98701d9c5c478909454594e --- /dev/null +++ b/108/InvasionFront_CD3_block19_x4_y3_patient108_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15142.0, + "Centroid Y µm": 10144.6, + "Num Detections": 17003, + "Num Negative": 16455, + "Num Positive": 548, + "Positive %": 3.223, + "Num Positive per mm^2": 266.54 + } +} \ No newline at end of file diff --git a/108/InvasionFront_CD8_block19_x3_y3_patient108_0.json b/108/InvasionFront_CD8_block19_x3_y3_patient108_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14eac3064d35c4763a6fffbc5d760161448c48c3 --- /dev/null +++ b/108/InvasionFront_CD8_block19_x3_y3_patient108_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11868.7, + "Centroid Y µm": 17540.7, + "Num Detections": 28364, + "Num Negative": 28070, + "Num Positive": 294, + "Positive %": 1.037, + "Num Positive per mm^2": 106.4 + } +} \ No newline at end of file diff --git a/108/InvasionFront_CD8_block19_x4_y3_patient108_1.json b/108/InvasionFront_CD8_block19_x4_y3_patient108_1.json new file mode 100644 index 0000000000000000000000000000000000000000..68864fda4a309f7f1c2bc67d5b2703c7db7c5950 --- /dev/null +++ b/108/InvasionFront_CD8_block19_x4_y3_patient108_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14517.3, + "Centroid Y µm": 17540.7, + "Num Detections": 26120, + "Num Negative": 25196, + "Num Positive": 924, + "Positive %": 3.538, + "Num Positive per mm^2": 342.8 + } +} \ No newline at end of file diff --git a/108/TumorCenter_CD3_block19_x3_y3_patient108_0.json b/108/TumorCenter_CD3_block19_x3_y3_patient108_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9b954713599d76b583531b56c71391743a4f1ada --- /dev/null +++ b/108/TumorCenter_CD3_block19_x3_y3_patient108_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10769.3, + "Centroid Y µm": 8770.4, + "Num Detections": 31991, + "Num Negative": 31238, + "Num Positive": 753, + "Positive %": 2.354, + "Num Positive per mm^2": 252.74 + } +} \ No newline at end of file diff --git a/108/TumorCenter_CD3_block19_x4_y3_patient108_1.json b/108/TumorCenter_CD3_block19_x4_y3_patient108_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f1774f237ff2ea24b5c4e680385c839ea5dae648 --- /dev/null +++ b/108/TumorCenter_CD3_block19_x4_y3_patient108_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 8270.6, + "Num Detections": 29868, + "Num Negative": 29094, + "Num Positive": 774, + "Positive %": 2.591, + "Num Positive per mm^2": 275.01 + } +} \ No newline at end of file diff --git a/108/TumorCenter_CD8_block19_x3_y3_patient108_0.json b/108/TumorCenter_CD8_block19_x3_y3_patient108_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3348a5105ce68cee5456cbbfea9530947f779027 --- /dev/null +++ b/108/TumorCenter_CD8_block19_x3_y3_patient108_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 18565.2, + "Num Detections": 32035, + "Num Negative": 31587, + "Num Positive": 448, + "Positive %": 1.398, + "Num Positive per mm^2": 149.15 + } +} \ No newline at end of file diff --git a/108/TumorCenter_CD8_block19_x4_y3_patient108_1.json b/108/TumorCenter_CD8_block19_x4_y3_patient108_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c7db69633de6775cab980fbe3225dcf7accfe13 --- /dev/null +++ b/108/TumorCenter_CD8_block19_x4_y3_patient108_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 18365.3, + "Num Detections": 30708, + "Num Negative": 30179, + "Num Positive": 529, + "Positive %": 1.723, + "Num Positive per mm^2": 185.4 + } +} \ No newline at end of file diff --git a/108/history_text.txt b/108/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/108/icd_codes.txt b/108/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4a9370e80708c773464060031b94c478294fde5a --- /dev/null +++ b/108/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Supraglottis[C32.1 R] \ No newline at end of file diff --git a/108/ops_codes.txt b/108/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cfd084c2234ce2213f976bb327ab3d1951412ce1 --- /dev/null +++ b/108/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/108/patient_clinical_data.json b/108/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..242f382a4f0dbbdbe0d94a47e871f9da63ddc68a --- /dev/null +++ b/108/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 76, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/108/patient_pathological_data.json b/108/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..15be4559b0503839f6f1a998e345413a241ae0e1 --- /dev/null +++ b/108/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "108", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/108/surgery_description.txt b/108/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..976b57c76edc7782a59ba8e3acdd5573bcbfd6c7 --- /dev/null +++ b/108/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, PEG placement diff --git a/108/surgery_report.txt b/108/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a18409955d72f31f55789e437077bd8619caf170 --- /dev/null +++ b/108/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Positioning of the patient. Laryngoscopic insertion of the flexible esophagoscope into the esophagus. Mirroring under visualization into the stomach, where a regular folded relief can be seen. If the diaphanoscopy is positive, the PEG tube is placed in the typical position using the thread pull-through method. This was successful without any problems. The patient was given an antibiotic cover intraoperatively. When withdrawing the esophagoscope, careful inspection of the esophageal mucosa, which is normal and inconspicuous. Dressing is applied. Reposition the patient for transoral laser resection. To do this, adjust the supraglottic plane with the spreading laryngoscope. The tumor extends laterally over the entire right arytenoid cusp up to the pharyngoepiglottic fold and the medial piriform sinus wall. The tumor is cut around with the CO2 laser and carefully dissected in a circular fashion with a sufficient safety margin. Vascular inflows are repeatedly monopolar coagulated during the dissection. Part of the pharyngoepiglottic fold is successfully preserved. It is also possible to preserve most of the cartilaginous arytenoid and only partially resect it. The tumor certainly does not reach the tip of the piriform sinus and can also be removed here with a sufficient safety margin far above the esophageal entrance level. In the area of the Arys, take a representative sample of the edge, which is described intraoperatively as tumor-free. In the area of the other resection margins, the tumor appears to be resected far in sano, so that only marginal samples are sent for final histology. These completely depict the tumor resection. Subsequent subtle hemostasis using monopolar coagulation. Dry wound conditions and very good aspect. If the wound conditions are dry and the arytenoid is standing, the tracheostomy can be omitted here. The patient should be fed via the PEG tube for the first few postoperative days. Then slowly build up the diet with porridge. Transfer the patient for neck dissection on both sides. Start with the neck dissection on the right side. Make an incision along the sternocleidomastoid muscle. Dissect in depth in layers and expose the cervical vascular sheath. Separate the neck preparation over the cervical vascular sheath. A conglomerate of enlarged lymph nodes can be seen in the area of the vein angle. Exposure of the resection borders with the omohyoid muscle, the submandibular gland and the digaster. Exposure and protection of the accessorius nerve. Long-distance dissection of the cervical vascular sheath with long-distance dissection of the vagus nerve. Displacement and, at the end of the operation, re-embedding of the accessory nerve, hypoglossal nerve and vagus nerve in the sense of a neurolysis. Subsequent resection of the lateral neck preparation together with the accessorius triangle. Removal of the hypoglossal triangle and then the ventral neck preparation. The final result is a resection of levels Ib to V. All outlets of the internal jugular vein and external carotid artery can be preserved during dissection. Careful irrigation of the wound. Dry wound conditions. Insertion of a size 10 Redon drain. Two-layer wound closure. Application of a pressure dressing. Neck dissection of the left side. Almost identical procedure here. This also results in the dissection of levels Ib to V. All vessels in the sense of the branches of the internal jugular vein and the external carotid artery can also be preserved here. Displacement and, at the end of the operation, re-embedding of the vagus nerve, accessorius nerve and hypoglossal nerve in the sense of a neurolysis. No conspicuous nodes were found in the area of the left neck during dissection. Dry wound conditions. Irrigation of the neck and insertion of a size 10 Redon drain. Two-layer wound closure. Application of a pressure dressing. Final consultation with the anesthetist. Completion of the procedure. \ No newline at end of file diff --git a/109/InvasionFront_CD3_block11_x3_y10_patient109_0.json b/109/InvasionFront_CD3_block11_x3_y10_patient109_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f4bc3843223d4ccd5b9581ae53cb8e9812308b53 --- /dev/null +++ b/109/InvasionFront_CD3_block11_x3_y10_patient109_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 24062.3, + "Num Detections": 18467, + "Num Negative": 15515, + "Num Positive": 2952, + "Positive %": 15.99, + "Num Positive per mm^2": 1381.6 + } +} \ No newline at end of file diff --git a/109/InvasionFront_CD3_block11_x4_y10_patient109_1.json b/109/InvasionFront_CD3_block11_x4_y10_patient109_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6fa4c48627d828e58624a2b52417017891cb2bee --- /dev/null +++ b/109/InvasionFront_CD3_block11_x4_y10_patient109_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 23987.3, + "Num Detections": 22151, + "Num Negative": 20920, + "Num Positive": 1231, + "Positive %": 5.557, + "Num Positive per mm^2": 551.02 + } +} \ No newline at end of file diff --git a/109/InvasionFront_CD8_block11_x3_y10_patient109_0.json b/109/InvasionFront_CD8_block11_x3_y10_patient109_0.json new file mode 100644 index 0000000000000000000000000000000000000000..12346f851015316f964178a34071fb0edab50b8c --- /dev/null +++ b/109/InvasionFront_CD8_block11_x3_y10_patient109_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13631.3, + "Centroid Y µm": 35351.1, + "Num Detections": 18823, + "Num Negative": 17133, + "Num Positive": 1690, + "Positive %": 8.978, + "Num Positive per mm^2": 812.36 + } +} \ No newline at end of file diff --git a/109/InvasionFront_CD8_block11_x4_y10_patient109_1.json b/109/InvasionFront_CD8_block11_x4_y10_patient109_1.json new file mode 100644 index 0000000000000000000000000000000000000000..42fbce6279f13f7c26a3da6dc9c544933cfb8751 --- /dev/null +++ b/109/InvasionFront_CD8_block11_x4_y10_patient109_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16195.9, + "Centroid Y µm": 35322.4, + "Num Detections": 21994, + "Num Negative": 21227, + "Num Positive": 767, + "Positive %": 3.487, + "Num Positive per mm^2": 355.46 + } +} \ No newline at end of file diff --git a/109/TumorCenter_CD3_block11_x3_y10_patient109_0.json b/109/TumorCenter_CD3_block11_x3_y10_patient109_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1bd1d9849f812bd6c6f2da0297a9802ca0ce160c --- /dev/null +++ b/109/TumorCenter_CD3_block11_x3_y10_patient109_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 24761.9, + "Num Detections": 22003, + "Num Negative": 20469, + "Num Positive": 1534, + "Positive %": 6.972, + "Num Positive per mm^2": 661.25 + } +} \ No newline at end of file diff --git a/109/TumorCenter_CD3_block11_x4_y10_patient109_1.json b/109/TumorCenter_CD3_block11_x4_y10_patient109_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9a36b4e01d67fceae30be748b7fd7f68f05df140 --- /dev/null +++ b/109/TumorCenter_CD3_block11_x4_y10_patient109_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 25061.7, + "Num Detections": 8263, + "Num Negative": 7841, + "Num Positive": 422, + "Positive %": 5.107, + "Num Positive per mm^2": 441.39 + } +} \ No newline at end of file diff --git a/109/TumorCenter_CD8_block11_x3_y10_patient109_0.json b/109/TumorCenter_CD8_block11_x3_y10_patient109_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3b78786f6e5e40f167fca808f8ab178cbda31d34 --- /dev/null +++ b/109/TumorCenter_CD8_block11_x3_y10_patient109_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 24612.0, + "Num Detections": 24284, + "Num Negative": 22614, + "Num Positive": 1670, + "Positive %": 6.877, + "Num Positive per mm^2": 680.1 + } +} \ No newline at end of file diff --git a/109/TumorCenter_CD8_block11_x4_y10_patient109_1.json b/109/TumorCenter_CD8_block11_x4_y10_patient109_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c6a1b19fc987b3ca7d935c97667e051d2aed893b --- /dev/null +++ b/109/TumorCenter_CD8_block11_x4_y10_patient109_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 25036.7, + "Num Detections": 18094, + "Num Negative": 16995, + "Num Positive": 1099, + "Positive %": 6.074, + "Num Positive per mm^2": 583.64 + } +} \ No newline at end of file diff --git a/109/history_text.txt b/109/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2018d7e477bff25c5b8a45b3c777bf8cd936aa9e --- /dev/null +++ b/109/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tonsillar carcinoma of the right tonsil. p16 status positive. Therefore above mentioned surgery indicated. \ No newline at end of file diff --git a/109/icd_codes.txt b/109/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/109/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/109/ops_codes.txt b/109/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..468d48a619d2a8d8a6357c588469ea5da4c5cf99 --- /dev/null +++ b/109/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie (ohne Adenotomie): Radikal, transoral[5-281.2 ] Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 R] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 3 Regionen[5-403.02 L] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] \ No newline at end of file diff --git a/109/patient_clinical_data.json b/109/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..41635c8550fd457bd6b3cc302b5ed3d964ca3419 --- /dev/null +++ b/109/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/109/patient_pathological_data.json b/109/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..db0b4a59426a09cc7d68409642ac43321a04db47 --- /dev/null +++ b/109/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "109", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 54, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/109/surgery_description.txt b/109/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c2329a872c6184ea9c75c44c7d712974ad44c27b --- /dev/null +++ b/109/surgery_description.txt @@ -0,0 +1 @@ +Expanded tonsillectomy, Bilateral neck dissection diff --git a/109/surgery_report.txt b/109/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6d5f9d1c49718981ad5a7663c2c45aa379b880c8 --- /dev/null +++ b/109/surgery_report.txt @@ -0,0 +1 @@ +Initially extended tonsillectomy: Tumor is located at the upper pole of the tonsil, slightly exceeding it cranially. Tumor is incised on all sides with a safety margin of more than 1 cm and removed. Goes to pathology marked with a suture. In addition, a marginal sample from the soft tissues is also sent to the frozen section as a craniobasal marginal sample. Here in the frozen section all specimens are healthy. Thus R0 resection. Repositioning for neck dissection on both sides: skin disinfection, draping. Start with the right side: skin incision in typical manner. Exposure of sternocleidomastoid muscle, exposure of omohyoid muscle and digastric muscle. Large cranial metastasis. Exposure of the cervical vascular sheath, internal and external carotid artery, internal jugular vein and vagus nerve as well as the accessorius and hypoglossal nerves. Subsequent development of the dorsal neck preparation. Knots can be detached from all structures, sometimes with some difficulty. Development of the dorsal neck preparation ........................., clearing also level V a and b. Subsequent development of the anterior neck preparation with visualization and preservation of the superior thyroid artery and hypoglossal nerve. Here now also revision level I b. Here, some lymph nodes in front of and behind the submandibular gland, including its capsule, are also removed. This ultimately results in partial level I and II to V removal. Neck dissection on the left: This is performed in the same way as on the right side, exposing the structures described. Levels II to IV are removed here in a typical manner. Significantly enlarged cranial lymph nodes are also seen here. Then hemostasis and irrigation with H2O2 and Ringer's solution and layered wound closure and insertion of a Redon drain. Subsequent PEG insertion: This is performed with . Advance the flexible esophagoscope into the stomach. No abnormalities on rough examination. A 9 mm abdominal wall probe is inserted in the typical manner. Then fixation to the abdominal wall. Now an enoral check: the site is unremarkable after an extended tonsillectomy without bleeding. This ends the procedure. Patient receives Sobelin 600 mg i.v. as a single shot. \ No newline at end of file diff --git a/110/InvasionFront_CD3_block8_x5_y2_patient110_0.json b/110/InvasionFront_CD3_block8_x5_y2_patient110_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5ff7b07e48e34ecba95bc4166e92d0a01bfedb60 --- /dev/null +++ b/110/InvasionFront_CD3_block8_x5_y2_patient110_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 15067.0, + "Num Detections": 24417, + "Num Negative": 23219, + "Num Positive": 1198, + "Positive %": 4.906, + "Num Positive per mm^2": 441.61 + } +} \ No newline at end of file diff --git a/110/InvasionFront_CD3_block8_x6_y2_patient110_1.json b/110/InvasionFront_CD3_block8_x6_y2_patient110_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0a6a4d91adf3841d488f21f5bedcc5c39ad582da --- /dev/null +++ b/110/InvasionFront_CD3_block8_x6_y2_patient110_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 15092.0, + "Num Detections": 21703, + "Num Negative": 20643, + "Num Positive": 1060, + "Positive %": 4.884, + "Num Positive per mm^2": 402.16 + } +} \ No newline at end of file diff --git a/110/InvasionFront_CD8_block8_x5_y2_patient110_0.json b/110/InvasionFront_CD8_block8_x5_y2_patient110_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6f72441be1b6a38984fd901f480bcbc73c6f9b9c --- /dev/null +++ b/110/InvasionFront_CD8_block8_x5_y2_patient110_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17515.7, + "Centroid Y µm": 5272.2, + "Num Detections": 23837, + "Num Negative": 23618, + "Num Positive": 219, + "Positive %": 0.9187, + "Num Positive per mm^2": 80.76 + } +} \ No newline at end of file diff --git a/110/InvasionFront_CD8_block8_x6_y2_patient110_1.json b/110/InvasionFront_CD8_block8_x6_y2_patient110_1.json new file mode 100644 index 0000000000000000000000000000000000000000..785a948c6747a6e86030077c08fe200735798e9d --- /dev/null +++ b/110/InvasionFront_CD8_block8_x6_y2_patient110_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20064.4, + "Centroid Y µm": 5372.2, + "Num Detections": 23140, + "Num Negative": 22764, + "Num Positive": 376, + "Positive %": 1.625, + "Num Positive per mm^2": 139.32 + } +} \ No newline at end of file diff --git a/110/TumorCenter_CD3_block8_x5_y2_patient110_0.json b/110/TumorCenter_CD3_block8_x5_y2_patient110_0.json new file mode 100644 index 0000000000000000000000000000000000000000..43e6b83bd8af752a4fa3c7922f8883087f1bd488 --- /dev/null +++ b/110/TumorCenter_CD3_block8_x5_y2_patient110_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15541.8, + "Centroid Y µm": 5372.2, + "Num Detections": 21518, + "Num Negative": 18372, + "Num Positive": 3146, + "Positive %": 14.62, + "Num Positive per mm^2": 1158.2 + } +} \ No newline at end of file diff --git a/110/TumorCenter_CD3_block8_x6_y2_patient110_1.json b/110/TumorCenter_CD3_block8_x6_y2_patient110_1.json new file mode 100644 index 0000000000000000000000000000000000000000..435b6b807baf402b4fc4f38aa203a1dc6d225ca0 --- /dev/null +++ b/110/TumorCenter_CD3_block8_x6_y2_patient110_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17965.5, + "Centroid Y µm": 5097.3, + "Num Detections": 22447, + "Num Negative": 20213, + "Num Positive": 2234, + "Positive %": 9.952, + "Num Positive per mm^2": 815.07 + } +} \ No newline at end of file diff --git a/110/TumorCenter_CD8_block8_x5_y2_patient110_0.json b/110/TumorCenter_CD8_block8_x5_y2_patient110_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8b0cf6e5780e20e62589f564d6a5a0507064ebf4 --- /dev/null +++ b/110/TumorCenter_CD8_block8_x5_y2_patient110_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 5197.2, + "Num Detections": 24837, + "Num Negative": 24323, + "Num Positive": 514, + "Positive %": 2.069, + "Num Positive per mm^2": 183.7 + } +} \ No newline at end of file diff --git a/110/TumorCenter_CD8_block8_x6_y2_patient110_1.json b/110/TumorCenter_CD8_block8_x6_y2_patient110_1.json new file mode 100644 index 0000000000000000000000000000000000000000..40e75366dfa3567cc835ad41652db514b15ddaa1 --- /dev/null +++ b/110/TumorCenter_CD8_block8_x6_y2_patient110_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 4997.4, + "Num Detections": 23988, + "Num Negative": 23548, + "Num Positive": 440, + "Positive %": 1.834, + "Num Positive per mm^2": 158.04 + } +} \ No newline at end of file diff --git a/110/history_text.txt b/110/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..515378389a63dcae36f98f199740bd0224f3cba6 --- /dev/null +++ b/110/history_text.txt @@ -0,0 +1 @@ +Mr. has an externally histologically confirmed squamous cell carcinoma of the left uvula. Sonographically cN0 neck status. Therefore, overall indication for the above-mentioned procedure. \ No newline at end of file diff --git a/110/icd_codes.txt b/110/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d1dcbef33712e70bb537f5f0d27e46c0f20ebcd --- /dev/null +++ b/110/icd_codes.txt @@ -0,0 +1 @@ +Uvulakarzinom[C05.2 ] \ No newline at end of file diff --git a/110/ops_codes.txt b/110/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b25e6d843fafb1bb066d5ddf0edc49767991a07 --- /dev/null +++ b/110/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische ÖGD[1-632 ] Weichgaumenteilresektion[5-272.1 ] Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] \ No newline at end of file diff --git a/110/patient_clinical_data.json b/110/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..069a119e0c8c4c1312f97e36e2f7503814594c63 --- /dev/null +++ b/110/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/110/patient_pathological_data.json b/110/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f4bb3b45fbcf8103eb5edb3ecfae7fca7464cb29 --- /dev/null +++ b/110/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "110", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/110/surgery_description.txt b/110/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a4ce050c09ebbc0a3728a054e128a96177b7ceb7 --- /dev/null +++ b/110/surgery_description.txt @@ -0,0 +1 @@ +Partial soft palate resection, Panendoscopy diff --git a/110/surgery_report.txt b/110/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ccc267cd96e1e084231fc2083b45f837a0e0d4f2 --- /dev/null +++ b/110/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, direct tracheoscopy is performed by the surgeon. The endolarynx and the trachea down to the carina are found to be normal. The patient is now intubated by the anesthesia colleagues. The surgeon then positioned the patient's head. A team time-out was carried out before the start of the procedure. Now insertion of the mouthguard. Enter with the Kleinsasser C-tube for pharyngoscopy. First, advance the Kleinsasser tube into the hypopharynx and inspect both piriform sinuses down to the esophageal entrance. Here as well as in the postcricoid area inconspicuous mucosal conditions. Now inspection of the larynx. However, there are no abnormalities here, nor in the interaryngeal region. The epiglottis and vallecula as well as the base of the tongue are also unremarkable. Now insertion of the Mc Ivor mouth spatula and initially careful inspection of the oral cavity and palpation, which revealed no further abnormalities. The overall dental status is incomplete. An approximately 1.5 x 1.5 cm large, partly exophytic, partly crater-shaped tumor is now visible in the area of the left-sided uvula base, which macroscopically reaches at least the midline and extends to the left tonsil lobe on the left side. The tonsils themselves are unremarkable on both sides. A right-sided velotracture was performed and the posterior surface of the soft palate was inspected. This is not penetrated by the tumor. Now demonstration of the findings to , who advises transoral resection in the sense of an excisional biopsy. The tumor is now incised on all sides with the electric needle with a sufficient safety distance of about 1 cm and the tumor is successively released alternately with bipolar coagulation. The uvula falls away completely. The posterior palatal arch can be partially preserved. In the area of the transition to the left tonsil lobe, the resectate is ultimately only very barely in sano macroscopically. Therefore, a generous resection is performed here again. The tumor specimen and the resected specimen are thread-marked and sent for frozen section examination. The frozen section shows the area in question on the main specimen to be only 1 mm in sano, but the resected specimen shows no evidence of carcinoma extension. The resectate is therefore assessed as R0 in the frozen section. Careful hemostasis using bipolar coagulation. After sufficient waiting time, check again for blood dryness, which is present. In the meantime, perform the OED. Under good visualization, pre-mirroring into the stomach. Here the gastric mucosa is unremarkable on all sides. On endoscopy, at most a slight change, consistent with mild reflux esophagitis. After consultation with , a PEG is currently not being used due to the primarily not expected functional problems. The procedure was therefore completed without complications. Repositioning of the patient by the surgeon. Conclusion: R0 resection of a left-sided cT1 uvula carcinoma in a frozen section. An elective neck dissection on both sides is nevertheless indicated and should be planned on the second side. Furthermore, chest X-ray to complete the staging. Presentation of the patient after neck dissection in the tumor conference. \ No newline at end of file diff --git a/111/InvasionFront_CD3_block14_x1_y11_patient111_0.json b/111/InvasionFront_CD3_block14_x1_y11_patient111_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a37a3200e95510b7b1d571a22a747c14ad7c66ff --- /dev/null +++ b/111/InvasionFront_CD3_block14_x1_y11_patient111_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4047.9, + "Centroid Y µm": 31133.5, + "Num Detections": 17738, + "Num Negative": 17705, + "Num Positive": 33, + "Positive %": 0.186, + "Num Positive per mm^2": 16.26 + } +} \ No newline at end of file diff --git a/111/InvasionFront_CD3_block14_x2_y11_patient111_1.json b/111/InvasionFront_CD3_block14_x2_y11_patient111_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ddb9e0c17f7473b4fe93fd1c838a0455c20c3f9 --- /dev/null +++ b/111/InvasionFront_CD3_block14_x2_y11_patient111_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 31183.5, + "Num Detections": 14763, + "Num Negative": 14518, + "Num Positive": 245, + "Positive %": 1.66, + "Num Positive per mm^2": 144.85 + } +} \ No newline at end of file diff --git a/111/InvasionFront_CD8_block14_x1_y11_patient111_0.json b/111/InvasionFront_CD8_block14_x1_y11_patient111_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fe910f983168b7db40291126247ba59d32d1e0c3 --- /dev/null +++ b/111/InvasionFront_CD8_block14_x1_y11_patient111_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4572.6, + "Centroid Y µm": 26835.8, + "Num Detections": 14823, + "Num Negative": 14797, + "Num Positive": 26, + "Positive %": 0.1754, + "Num Positive per mm^2": 14.06 + } +} \ No newline at end of file diff --git a/111/InvasionFront_CD8_block14_x2_y11_patient111_1.json b/111/InvasionFront_CD8_block14_x2_y11_patient111_1.json new file mode 100644 index 0000000000000000000000000000000000000000..82799251b4f8f7ed50d6b30ff6cdc67fde328b3c --- /dev/null +++ b/111/InvasionFront_CD8_block14_x2_y11_patient111_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6921.3, + "Centroid Y µm": 26735.8, + "Num Detections": 19907, + "Num Negative": 19711, + "Num Positive": 196, + "Positive %": 0.9846, + "Num Positive per mm^2": 85.96 + } +} \ No newline at end of file diff --git a/111/TumorCenter_CD3_block14_x1_y11_patient111_0.json b/111/TumorCenter_CD3_block14_x1_y11_patient111_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3d7f5cf57e2a12151f8d548aa89e0e412060db49 --- /dev/null +++ b/111/TumorCenter_CD3_block14_x1_y11_patient111_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3573.1, + "Centroid Y µm": 27360.5, + "Num Detections": 20195, + "Num Negative": 18421, + "Num Positive": 1774, + "Positive %": 8.784, + "Num Positive per mm^2": 751.22 + } +} \ No newline at end of file diff --git a/111/TumorCenter_CD3_block14_x2_y11_patient111_1.json b/111/TumorCenter_CD3_block14_x2_y11_patient111_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a4adea2bdebe34880dabdd02f6edfc27a6eb2594 --- /dev/null +++ b/111/TumorCenter_CD3_block14_x2_y11_patient111_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6021.8, + "Centroid Y µm": 27535.4, + "Num Detections": 15871, + "Num Negative": 15437, + "Num Positive": 434, + "Positive %": 2.735, + "Num Positive per mm^2": 223.53 + } +} \ No newline at end of file diff --git a/111/TumorCenter_CD8_block14_x1_y11_patient111_0.json b/111/TumorCenter_CD8_block14_x1_y11_patient111_0.json new file mode 100644 index 0000000000000000000000000000000000000000..94a764306b1f660cc9a4dae9aacece365e111781 --- /dev/null +++ b/111/TumorCenter_CD8_block14_x1_y11_patient111_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3348.2, + "Centroid Y µm": 27835.3, + "Num Detections": 21594, + "Num Negative": 20407, + "Num Positive": 1187, + "Positive %": 5.497, + "Num Positive per mm^2": 488.58 + } +} \ No newline at end of file diff --git a/111/TumorCenter_CD8_block14_x2_y11_patient111_1.json b/111/TumorCenter_CD8_block14_x2_y11_patient111_1.json new file mode 100644 index 0000000000000000000000000000000000000000..72ee236330b30a1ac2d6436c7ffc2db43168fa8b --- /dev/null +++ b/111/TumorCenter_CD8_block14_x2_y11_patient111_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5771.9, + "Centroid Y µm": 27835.3, + "Num Detections": 16073, + "Num Negative": 15849, + "Num Positive": 224, + "Positive %": 1.394, + "Num Positive per mm^2": 109.67 + } +} \ No newline at end of file diff --git a/111/history_text.txt b/111/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/111/icd_codes.txt b/111/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d2cf60dd1609b908c6ae08df3dc6a951fea4c088 --- /dev/null +++ b/111/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zunge, mehrere Teilbereiche überlappend[C02.8 ] Bösartige Neubildung im Bereich der Zungengruben[C10.0 ] \ No newline at end of file diff --git a/111/ops_codes.txt b/111/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..11827b9adedfcfdd95131324399a247f32264d13 --- /dev/null +++ b/111/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral Rekonstruktion mit nicht vaskularisiertem Transplantat[5-251.01 ] \ No newline at end of file diff --git a/111/patient_clinical_data.json b/111/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3861c667ff326035e8c0296f0a149b6f026ef77a --- /dev/null +++ b/111/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 81, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 40, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/111/patient_pathological_data.json b/111/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4391a83540e9c0820e2b5c8507e5e2546760e0d4 --- /dev/null +++ b/111/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "111", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/111/surgery_description.txt b/111/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..75c9bf7f758ab6a630ef73c278517ca376c365a3 --- /dev/null +++ b/111/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy diff --git a/111/surgery_report.txt b/111/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..300bc81db1097b1c9b24a7925ce41a3c3d7487c5 --- /dev/null +++ b/111/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Then inspection of the oral cavity. A large ulcer-like tumor is found on the edge of the tongue on the left. The tumor extends into the deep muscles of the tongue, reaching at least to the midline. The base of the tongue and the tip of the tongue itself are free. Now cut around the tumor, initially with the monopolar needle. The tumour passes into the mucosa of the floor of the mouth in the floor of the mouth area, here again exposing the Wharton's duct, which is probed and marsupialized with the mucosa. Excision of the tumor in the usual manner using scissors and bipolar forceps in a dissection technique. Removal of marginal samples from the removed tumor specimen, all marginal samples are diagnosed as R0 in the frozen section. Decision to cover the defect with fascia lata. A free graft is out of the question, as there is still sufficient residual tongue tissue and the patient is adequately supplied with the residual tongue findings, taking into account her age and previous illness. The fascia lata is trimmed and successively stitched open. In the case of cN0 neck, neck dissection is not performed. Close monitoring should be carried out here. Presentation of the patient in the tumor conference. Intraoperative demonstration of the findings to . \ No newline at end of file diff --git a/112/InvasionFront_CD8_block6_x5_y12_patient112_0.json b/112/InvasionFront_CD8_block6_x5_y12_patient112_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f24258ba0e2ccc7e68c83cdf131d815699c05759 --- /dev/null +++ b/112/InvasionFront_CD8_block6_x5_y12_patient112_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 30683.8, + "Num Detections": 9508, + "Num Negative": 9310, + "Num Positive": 198, + "Positive %": 2.082, + "Num Positive per mm^2": 128.57 + } +} \ No newline at end of file diff --git a/112/InvasionFront_CD8_block6_x6_y12_patient112_1.json b/112/InvasionFront_CD8_block6_x6_y12_patient112_1.json new file mode 100644 index 0000000000000000000000000000000000000000..50805d743178d63cbc4eb40a3515dd777b368612 --- /dev/null +++ b/112/InvasionFront_CD8_block6_x6_y12_patient112_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 31008.6, + "Num Detections": 13422, + "Num Negative": 12813, + "Num Positive": 609, + "Positive %": 4.537, + "Num Positive per mm^2": 297.36 + } +} \ No newline at end of file diff --git a/112/TumorCenter_CD3_block6_x5_y12_patient112_0.json b/112/TumorCenter_CD3_block6_x5_y12_patient112_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7c03ce5e9f3b94093c8077aff33f07fa13ba3c5f --- /dev/null +++ b/112/TumorCenter_CD3_block6_x5_y12_patient112_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 30333.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/112/TumorCenter_CD3_block6_x6_y12_patient112_1.json b/112/TumorCenter_CD3_block6_x6_y12_patient112_1.json new file mode 100644 index 0000000000000000000000000000000000000000..74f4fcaa052fc50be78b3801ab9a25fa02c61e61 --- /dev/null +++ b/112/TumorCenter_CD3_block6_x6_y12_patient112_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 29859.2, + "Num Detections": 153, + "Num Negative": 142, + "Num Positive": 11, + "Positive %": 7.19, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/112/TumorCenter_CD8_block6_x5_y12_patient112_0.json b/112/TumorCenter_CD8_block6_x5_y12_patient112_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a68c8629ff2cee607fd1689c6956d38c332504b5 --- /dev/null +++ b/112/TumorCenter_CD8_block6_x5_y12_patient112_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 30758.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/112/TumorCenter_CD8_block6_x6_y12_patient112_1.json b/112/TumorCenter_CD8_block6_x6_y12_patient112_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0cdd621335bd0a5f0af1a07fe7aeb827bde5af21 --- /dev/null +++ b/112/TumorCenter_CD8_block6_x6_y12_patient112_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 30758.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/112/history_text.txt b/112/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/112/icd_codes.txt b/112/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/112/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/112/ops_codes.txt b/112/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f14114e10d4f4d5790fc3dee4aed3e3065c246c --- /dev/null +++ b/112/ops_codes.txt @@ -0,0 +1 @@ +Transmandibuläre partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.34 ] Sagittale Spaltung Unterkiefer frontal[5-776.2 ] Glossektomie durch temporäre Mandibulotomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-252.12 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.48 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/112/patient_clinical_data.json b/112/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cf747f0d6882937b2d9e51c9911166ce8f22665c --- /dev/null +++ b/112/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/112/patient_pathological_data.json b/112/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d1263415148c41cf322df65378d8bab96c733776 --- /dev/null +++ b/112/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "112", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 44, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/112/surgery_description.txt b/112/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..041309d121bfcb0ec1a98c31a14549d72570d713 --- /dev/null +++ b/112/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Free flap coverage (ALT) diff --git a/112/surgery_report.txt b/112/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1daf2374b56b85de34323ce4dc82c1b7fab4cc80 --- /dev/null +++ b/112/surgery_report.txt @@ -0,0 +1 @@ +After intubation, a microlaryngoscopy and oropharyngoscopy were performed again. The exphytically growing tumor in the area of the right tonsil region can be seen, passing over to the base of the tongue towards the valecula. The piriform sinus on both sides, the visible larynx and the base of the tongue on the left are unremarkable. Oedematous mucosa was probably noticed on CT. Now detailed consultation with the anesthesiologist regarding the intraoperative procedure. Due to the small mouth opening, the tumor can only be extirpated by splitting the lower jaw. Therefore, senior physician from the maxillofacial surgery department will be informed later about the mandibular division. First of all, start again with the PEG placement. Very difficult insertion of the flexible esophagoscope into the upper esophageal opening. Due to the very narrow conditions, it is finally possible to enter the oesophagus. Advance into the stomach. Inconspicuous conditions there. Good diaphanoscopy. Puncture of the stomach and insertion of the PEG tube. This cannot be pulled through, so check again with the MLE tube. There is a snag in the area of the tube. The tube is therefore removed again from the cranial side. Careful insertion of the flexible endoscope again. The esophagus is unremarkable. No evidence of perforation, advancement into the stomach. No bleeding there either, unremarkable conditions. Another puncture of the stomach and now problem-free insertion of the PEG tube. Perioperative administration of Unacid i.v.. Continue this postoperatively. Now start of neck dissection on the right side with preparation for splitting the lower jaw. To do this, make a skin incision in the area of the lower lip, moving onto the chin, onto the submandibular region and finally into the scar for neck dissection from the earlobe to the supraclavicular region. Dissection of the subcutaneous tissue and exposure of the sternocleidomastoid muscle. Exposure of the internal jugular vein, the facial vein and individual smaller veins. Exposure of the vagus nerve, accessorius nerve, digastric muscle, posterior vena cava. Very difficult dissection of metastatically altered lymph nodes from the jugular vein in the cranial part. Further dissection of the posterior neck preparation up to the supraclavicular region. There, the preparation was removed and repositioned to prevent a fistula. Now dissection of the hypoglossal nerve and the submandibular gland. Dissection of the anterior neck preparation with exposure of the external and internal carotid artery as well as the superior thyroid artery and the facial artery. The submandibular gland is also removed. To do this, dissect from the facial vein towards the mylohyoid muscle and cut and ligate the excretory duct. Removal of the submandibular gland. Neck dissection is also carried out in regions I and II a and b. All lymph nodes in the area of the facial vein medial to the mandible are removed and also included in the preparation. Now call in from the maxillofacial surgery department. He first fits a plate in the area of the lower jaw with eight screws. The lower jaw is then split in a staircase between the canine and the first molar. After opening the lower jaw, the muscles of the floor of the mouth are cut through and dissected in the direction of the tumor. Now very difficult resection of the tumor, initially in the area of the laternal tongue and the base of the tongue. Then further laterally into the upper retromolar region towards the hard and soft palate. Here, a large part of the hard and soft palate falls down to the uvula. Dissection of the tumor then in the depth of the pterygoid muscle. The tumor can be further detached here. It is now possible to remove the tumor in toto in the block with great effort. Circular marginal samples are taken and sent for frozen section. Result: All marginal samples are considered to be tumor-free, and the biopsy from the left valecula, which was also performed, shows no evidence of tumor. An A0 situation can be assumed. Now reposition the patient. Removal of the ALT. Then perform the neck dissection on the left side. Also make a skin incision on the front edge of the sternocleidomastoid muscle, from the earlobe to the jugulum. Dissection of the muscle, exposure of the internal jugular vein, the vagus nerve and the accessorius nerve. Dissection of the accessorius triangle after exposure of the digastric muscle, posterior vena cava. Dissection of the neck preparation caudally. Deposition supraclavicularly after repositioning. Finally, dissection of the facial vein, the external and internal carotid arteries and the hypoglossal nerve. Complete the anterior neck preparation, including the submandibular gland. Complete hemostasis with H2O2 swabs and bipolar coagulation. No more bleeding. Insertion of a Redon drainage, subcutaneous suture, skin suture and wound dressing. In this area. Now perform the tracheotomy. Y-shaped skin incision in the longitudinal direction. Dissection of the subcutaneous tissue, exposure of the infrahyoid musculature. Opening of the same in the area of the linea alba, exposure of the thyroid isthmus and the cricoid cartilage. Separation and transection of the thyroid isthmus. The trachea is now exposed and opened. Creation of a Björ flap. Opening of the trachea so that an 8 mm tube can be inserted without difficulty. Re-intubation of the patient and epithelization of the tracheostoma with non-absorbable sutures and simultaneous application of skin sutures in this area. Now the ALT taken from the thigh, which is sized accordingly, is fitted into the tumor resection area. Incision with several Vicryl sutures, initially in the area of the naso- and oropharynx. Very difficult conditions here. However, the flap now fits very well. Suturing in the area of the posterior pharyngeal wall, extending to the base of the tongue and the mandibular region as well as in the retromolar region. Very good fit of the flap. Now primary suture in the area of the floor of the mouth, both the musculature and the mucosa. Call in from the MKG. He closes and sutures the lower jaw and reattaches the perforated plate with eight screws for fixation. Very good fit. Occlusion fits. Now suction of wound secretions in the neck area and exposure of the superior thyroid artery and a large neck vein, which are well suited for anastomosis. First anastomosis of the artery. The artery is first anastomosed at the end. There are several leaks, so that the anastomosis is first cut once again and in the second attempt an anastomosis is achieved under microscopic control. Very good flow in the area of the artery. No leakage of blood. Repeated flushing with heparin. Finding the venous limb of the flap and dissection of a jugular vein. Using the coupler, the two venous ends can be approximated and anastomosed end-to-end. Very difficult dissection. Repeated irrigation with heparin. The venous return flow increases significantly over time, so that the arterial limb functions very well. After performing the coupler anastomosis, venous return is also very good. Flap well perfused. Adaptation of the anastomosis in the neck area. Now again thorough hemostasis with H2O2 irrigation and bipolar coagulation. No more bleeding. Insertion of Redon drains, subcutaneous and skin sutures. Closure also in the area of the lower lip and chin. No bleeding at the end of the operation. Detailed consultation with the anesthesiologist. Repeated administration of Unacid. Please pass this on postoperatively, paying particular attention to abdominal problems due to the two PEG insertions. Detailed consultation with the anesthesia department. The patient is intubated and ventilated and transferred to the intensive care unit for monitoring. This is followed by the surgical report for lifting the ALT flap of . After identification of the landmarks, doppler sonographic identification of the main perforator and three small secondary perforators. After measuring the graft configuration for soft palate and tongue base. Initial medial incision and separation of skin and subcutaneous tissue, visualization of the rectus femoris muscle, strictly subpartial preparation. Reliable identification of the muscle, visualization of the very strong main perforator, therefore limitation to the main perforator. Identification of the strong vascular pedicle. Complete cutting of the graft. This shows a purely fasciocutaneous graft. A relatively thin graft can therefore be lifted here. Completely recut, taking the fascia lata in the graft area with it. Careful protection of the main perforator, leaving a small muscle cuff in the area of the perforator outlet. Isolation on the vascular pedicle, exposure of the confluence of the veins, exposure of the strong artery. Protection of the ramus obliquus and, if the vitality of the graft is excellent, removal of the graft. Careful wound inspection, insertion of a 10-gauge redon drain and careful multi-layer wound closure. The graft is then implanted transmandibularly. \ No newline at end of file diff --git a/113/InvasionFront_CD3_block6_x3_y9_patient113_0.json b/113/InvasionFront_CD3_block6_x3_y9_patient113_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba4d00f54768f71c3262fd492b0d2af4491735f9 --- /dev/null +++ b/113/InvasionFront_CD3_block6_x3_y9_patient113_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11543.9, + "Centroid Y µm": 23387.6, + "Num Detections": 18121, + "Num Negative": 16820, + "Num Positive": 1301, + "Positive %": 7.18, + "Num Positive per mm^2": 666.74 + } +} \ No newline at end of file diff --git a/113/InvasionFront_CD3_block6_x4_y9_patient113_1.json b/113/InvasionFront_CD3_block6_x4_y9_patient113_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd898691e38d859445f96d2fa65bce57f4e53950 --- /dev/null +++ b/113/InvasionFront_CD3_block6_x4_y9_patient113_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14117.5, + "Centroid Y µm": 23637.5, + "Num Detections": 17924, + "Num Negative": 15861, + "Num Positive": 2063, + "Positive %": 11.51, + "Num Positive per mm^2": 1039.1 + } +} \ No newline at end of file diff --git a/113/InvasionFront_CD8_block6_x3_y7_patient113_0.json b/113/InvasionFront_CD8_block6_x3_y7_patient113_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3a85824a154de01d0ee563a7cbe9ff4291350582 --- /dev/null +++ b/113/InvasionFront_CD8_block6_x3_y7_patient113_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12118.6, + "Centroid Y µm": 17590.7, + "Num Detections": 21534, + "Num Negative": 21507, + "Num Positive": 27, + "Positive %": 0.1254, + "Num Positive per mm^2": 10.51 + } +} \ No newline at end of file diff --git a/113/InvasionFront_CD8_block6_x4_y7_patient113_1.json b/113/InvasionFront_CD8_block6_x4_y7_patient113_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a0fcf58f1f8fb610cb022c5f4b15b6b0645445c8 --- /dev/null +++ b/113/InvasionFront_CD8_block6_x4_y7_patient113_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14817.2, + "Centroid Y µm": 17740.6, + "Num Detections": 21298, + "Num Negative": 21292, + "Num Positive": 6, + "Positive %": 0.0282, + "Num Positive per mm^2": 2.341 + } +} \ No newline at end of file diff --git a/113/TumorCenter_CD3_block6_x3_y7_patient113_0.json b/113/TumorCenter_CD3_block6_x3_y7_patient113_0.json new file mode 100644 index 0000000000000000000000000000000000000000..abdbe83da8415f6ec5ee71b605e2739d9cac0c1f --- /dev/null +++ b/113/TumorCenter_CD3_block6_x3_y7_patient113_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 17890.5, + "Num Detections": 19247, + "Num Negative": 16842, + "Num Positive": 2405, + "Positive %": 12.5, + "Num Positive per mm^2": 1071.6 + } +} \ No newline at end of file diff --git a/113/TumorCenter_CD3_block6_x4_y7_patient113_1.json b/113/TumorCenter_CD3_block6_x4_y7_patient113_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ba6bf85f08223c1bbcb31fc8052fbbbd3f905808 --- /dev/null +++ b/113/TumorCenter_CD3_block6_x4_y7_patient113_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 17915.5, + "Num Detections": 13938, + "Num Negative": 12311, + "Num Positive": 1627, + "Positive %": 11.67, + "Num Positive per mm^2": 1016.2 + } +} \ No newline at end of file diff --git a/113/TumorCenter_CD8_block6_x3_y7_patient113_0.json b/113/TumorCenter_CD8_block6_x3_y7_patient113_0.json new file mode 100644 index 0000000000000000000000000000000000000000..47a5d28a93cc6589f281c15c5bf96e965492611c --- /dev/null +++ b/113/TumorCenter_CD8_block6_x3_y7_patient113_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 18240.3, + "Num Detections": 23053, + "Num Negative": 23051, + "Num Positive": 2, + "Positive %": 0.0087, + "Num Positive per mm^2": 0.7971 + } +} \ No newline at end of file diff --git a/113/TumorCenter_CD8_block6_x4_y7_patient113_1.json b/113/TumorCenter_CD8_block6_x4_y7_patient113_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9226719d315cdca4e03fb8e250a4eb958bfdad93 --- /dev/null +++ b/113/TumorCenter_CD8_block6_x4_y7_patient113_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 18290.3, + "Num Detections": 23907, + "Num Negative": 23825, + "Num Positive": 82, + "Positive %": 0.343, + "Num Positive per mm^2": 32.02 + } +} \ No newline at end of file diff --git a/113/history_text.txt b/113/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/113/icd_codes.txt b/113/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b5c889c54dbac0ddfb2f4ded4d7ee921c479f54c --- /dev/null +++ b/113/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Gaumen, mehrere Teilbereiche überlappend[C05.8 ] Karzinom des weichen Gaumens[C05.1 ] \ No newline at end of file diff --git a/113/ops_codes.txt b/113/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..94e619bec6534f8e64fd762bcd2a105c49b74418 --- /dev/null +++ b/113/ops_codes.txt @@ -0,0 +1 @@ +mikrovaskulär-anastomosierten Transplantat[5-295.24 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Temporäre Tracheotomie[5-311.0 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Entnahme freier Radialis-Lappen[5-858.23 L] \ No newline at end of file diff --git a/113/patient_clinical_data.json b/113/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f3c477c60e9de4ffcbfae0e01880b8d981c3da5 --- /dev/null +++ b/113/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/113/patient_pathological_data.json b/113/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..60e9813ae552a7bde15cebfe54825c1968b16ffa --- /dev/null +++ b/113/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "113", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/113/surgery_description.txt b/113/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6b3d566dfc12c525b1e37fbf6dc4e19050023422 --- /dev/null +++ b/113/surgery_description.txt @@ -0,0 +1 @@ +TU resection, Bilateral neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/113/surgery_report.txt b/113/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6326674ef35ba312bb147b5a8adb671df08683bf --- /dev/null +++ b/113/surgery_report.txt @@ -0,0 +1 @@ +The tumor can be seen consuming the entire uvula and extending along the anterior soft palate on the left side to the left posterior palatal arch on the left side. For G3 differentiation, a distance of 1 cm is measured and the resection margin is marked. Successive removal of the tumor from and alternately. The left tonsil is also removed here. After successive removal, the specimen is marked under inspection and palpation. Successive hemostasis. A resection is taken on the right parauvular side. Everything goes to the frozen section. The frozen section shows an R0 resection. Tracheotomy: skin incision, dissection through the subcutaneous fatty tissue. Dissection along the linea alba through the prelaryngeal musculature. Finding the cricoid cartilage. Careful coagulation of the thyroid gland and dissection of the thyroid gland. Free preparation of the trachea. Visor tracheotomy between the 2nd and 3rd tracheal clasp. Suturing in the usual manner. Neck dissection on the right side: skin incision and dissection through the subcutaneous fatty tissue. Exposure of the anterior border of the sternocleidomastoid muscle. Dissection in depth. Exposure and protection of the accessorius nerve. Exposure of the omohyoid muscle and cranial dissection. Exposure of the submandibular gland and finding the posterior venter of the digastric muscle. Exposure of the digastric muscle and successive dissection of this up to region II b. Multiple suspicious metastases are found in region II b, also in the jugulofacial angle. Dissection of the internal jugular vein and visualization of the same. It can be seen that the large metastasis in the jugulofacial angle is connected to the facial vein. For this reason, ligation of the facial vein and removal of the metastasis. The hypoglossal nerve can be identified and spared. Successive dissection of the other suspicious masses, sparing the internal jugular vein. Successive dissection of the lateral neck preparation while sparing the brachial plexus. Identification and protection of the vagus nerve. The cervical nerve can also be spared. Removal of the lateral neck preparation. Successive removal of the medial neck preparation. Irrigation and successive hemostasis. If there is no evidence of increased bleeding, insertion of a Redon drain. Two-layer wound closure. Lifting of the radial artery flap by and : marking of the radial artery. Palpatory identification of the distal radial artery. Marking of the flap borders 4 x 6 cm on the distal forearm proximal to the flexor retinaculum, with an S-shaped course. Cut proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue from proximal. Identification. Exposure of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the graft margin. It can be seen that the cephalic vein is pulling towards the skin, away from the planned skin island. The vein is therefore severed here. Identification of the external ramus of the radial nerve. Elevation of the radial part while leaving the fascia of the tendon of the brachioradialis muscle intact. Subsequent dissection down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the forearm graft edge up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendinous tissue on the flexor tendon and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes under good oxygen saturation measured by pulse oximetry, measured on the thumb, approx. 99%, the vessels are removed with subsequent ligation with silk thread. Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and sparing of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery and the mediana cubita, the ulnar artery. First of all, expose the radial artery. Then of two veins of the superficial venous system, vascular ligation using silk thread and vascular clips. Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Application of a wound dressing and forearm splint. Completion of graft elevation without complications. ND left skin incision and dissection through the subcutaneous fatty tissue. Exposure of the anterior border of the sternocleidomastoid muscle. Dissection in depth. Exposure and protection of the accessorius nerve. Exposure of the omohyoid muscle and cranial dissection. Exposure of the submandibular gland and finding the posterior venter of the digastric muscle. Exposure of the digastric muscle and successive dissection of this up to region II b. Dissection of the internal jugular vein and exposure of the same. Ligation of the facial vein and removal of the metastasis. The hypoglossal nerve can be identified and spared. Successive dissection of the lateral neck preparation while sparing the brachial plexus. Identification and protection of the vagus nerve. The cervical nerve can also be spared. Removal of the lateral neck preparation. Successive removal of the medial neck preparation. Dissection of the superior thyroid artery as a connecting vessel. After removal of the submandibular gland on the left side while protecting the lingual nerve, an orotracheal fistula is created to pull the flap through. This is pulled through and attached to the defect. The posterior part of the flap is sutured to the posterior palatal arch, the anterior part of the flap to the anterior palatal arch and the lateral part within the tonsillar ligament. This is done with 4-0 single button Vicryl sutures. Performing the anastomosis in the sense of an arterial anastomosis between the radial artery and the superior thyroid artery on the left side as well as two end-to-side anastomoses to the internal jugular vein. Insertion of a flap and a Redon drainage. Fixation of the pedicle with Vicryl sutures to prevent twisting of the pedicle. Two-layer wound closure. \ No newline at end of file diff --git a/114/InvasionFront_CD3_block2_x3_y4_patient114_0.json b/114/InvasionFront_CD3_block2_x3_y4_patient114_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0f0124fb9b9af631bad1d2293dac31c0c14c3c3e --- /dev/null +++ b/114/InvasionFront_CD3_block2_x3_y4_patient114_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 23537.5, + "Num Detections": 26102, + "Num Negative": 24214, + "Num Positive": 1888, + "Positive %": 7.233, + "Num Positive per mm^2": 701.05 + } +} \ No newline at end of file diff --git a/114/InvasionFront_CD3_block2_x4_y4_patient114_1.json b/114/InvasionFront_CD3_block2_x4_y4_patient114_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d042c56c2c0979730a9e1a0eabb57d986046144 --- /dev/null +++ b/114/InvasionFront_CD3_block2_x4_y4_patient114_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 23662.5, + "Num Detections": 25069, + "Num Negative": 22124, + "Num Positive": 2945, + "Positive %": 11.75, + "Num Positive per mm^2": 1177.2 + } +} \ No newline at end of file diff --git a/114/InvasionFront_CD8_block2_x3_y4_patient114_0.json b/114/InvasionFront_CD8_block2_x3_y4_patient114_0.json new file mode 100644 index 0000000000000000000000000000000000000000..048ec8258daa84ed6849a0cd67a601baed259f8c --- /dev/null +++ b/114/InvasionFront_CD8_block2_x3_y4_patient114_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12643.3, + "Centroid Y µm": 11194.1, + "Num Detections": 24882, + "Num Negative": 18124, + "Num Positive": 6758, + "Positive %": 27.16, + "Num Positive per mm^2": 2511.1 + } +} \ No newline at end of file diff --git a/114/InvasionFront_CD8_block2_x4_y4_patient114_1.json b/114/InvasionFront_CD8_block2_x4_y4_patient114_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f037690522bcef23e1dbaf93bf95307847bdaf62 --- /dev/null +++ b/114/InvasionFront_CD8_block2_x4_y4_patient114_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15092.0, + "Centroid Y µm": 11394.0, + "Num Detections": 12632, + "Num Negative": 9049, + "Num Positive": 3583, + "Positive %": 28.36, + "Num Positive per mm^2": 2611.0 + } +} \ No newline at end of file diff --git a/114/TumorCenter_CD3_block2_x3_y4_patient114_0.json b/114/TumorCenter_CD3_block2_x3_y4_patient114_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba9ad961be9dd7fef541488020888f9eb55d22c2 --- /dev/null +++ b/114/TumorCenter_CD3_block2_x3_y4_patient114_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11618.8, + "Centroid Y µm": 9794.8, + "Num Detections": 26055, + "Num Negative": 24014, + "Num Positive": 2041, + "Positive %": 7.833, + "Num Positive per mm^2": 807.68 + } +} \ No newline at end of file diff --git a/114/TumorCenter_CD3_block2_x4_y4_patient114_1.json b/114/TumorCenter_CD3_block2_x4_y4_patient114_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d21996d0162a0bd470c15fcd45ecafdb3fe8812 --- /dev/null +++ b/114/TumorCenter_CD3_block2_x4_y4_patient114_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14092.5, + "Centroid Y µm": 9869.8, + "Num Detections": 21870, + "Num Negative": 19031, + "Num Positive": 2839, + "Positive %": 12.98, + "Num Positive per mm^2": 1189.0 + } +} \ No newline at end of file diff --git a/114/TumorCenter_CD8_block2_x3_y4_patient114_0.json b/114/TumorCenter_CD8_block2_x3_y4_patient114_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7c2aed5bc3b4ecaf35048f230f18fb0afea8f625 --- /dev/null +++ b/114/TumorCenter_CD8_block2_x3_y4_patient114_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13018.1, + "Centroid Y µm": 9719.9, + "Num Detections": 26106, + "Num Negative": 23614, + "Num Positive": 2492, + "Positive %": 9.546, + "Num Positive per mm^2": 985.36 + } +} \ No newline at end of file diff --git a/114/TumorCenter_CD8_block2_x4_y4_patient114_1.json b/114/TumorCenter_CD8_block2_x4_y4_patient114_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f5760c06aac246b471ee3572f7ffc427ca9ae8d8 --- /dev/null +++ b/114/TumorCenter_CD8_block2_x4_y4_patient114_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15516.8, + "Centroid Y µm": 9544.9, + "Num Detections": 15577, + "Num Negative": 13950, + "Num Positive": 1627, + "Positive %": 10.44, + "Num Positive per mm^2": 967.88 + } +} \ No newline at end of file diff --git a/114/history_text.txt b/114/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/114/icd_codes.txt b/114/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..814d532cb5ac0519eb88dd4b513acc4022cc6bfc --- /dev/null +++ b/114/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hinterwand des Oropharynx[C10.3 ] Lymphknotenmetastasen onA[C77.9 ] \ No newline at end of file diff --git a/114/ops_codes.txt b/114/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e76bd81328b7706c8e835a74e78e092df5e95e44 --- /dev/null +++ b/114/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] Transorale Tumortonsillektomie[5-281.2 ] Selektive Neck dissection in 5 Regionen[5-403.04 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Pharyngoplastik mit mikrovaskulär anastomosiertem Transplantat[5-293.2 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/114/patient_clinical_data.json b/114/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6c9552cf77c48b3a922593479d41db83ad9860e9 --- /dev/null +++ b/114/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 88, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 41, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/114/patient_pathological_data.json b/114/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..72b490a89ecc7ab5dcdc0fb0b9725c66bf765d23 --- /dev/null +++ b/114/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "114", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 20.0 +} \ No newline at end of file diff --git a/114/surgery_description.txt b/114/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a9be8a3e04eeabe0939d3cf2722c78ca1af858e7 --- /dev/null +++ b/114/surgery_description.txt @@ -0,0 +1 @@ +Pharyngeal partial resection, Neck dissection, PEG placement, Free flap (Radial) diff --git a/114/surgery_report.txt b/114/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b524bf4d6c242508d0a8191e833cc9e57d03b7bc --- /dev/null +++ b/114/surgery_report.txt @@ -0,0 +1 @@ +: Initial inspection of the primary tumor region. A partially exulcerated, largely submucosal tumor of the left tonsil is seen. The tumor extends over the entire tonsillar lobe and just behind the lower jaw, but can just be moved here. Infiltration of the posterior palatal arch. Overall extensive mass. A good 5 x 4 cm in total. T3 stage due to its size. The tumor is now resected with an electric needle. Resection up to the parauvular level. Complete removal of the anterior palatal arch and towards the ascending mandibular branch. Successive lateral detachment using the dissection technique. Infiltration of the pharyngeal musculature. Resection of almost the entire parapharyngeal musculature. Here, broadly exposed neck fat tissue with vessels underneath. Exposure of the pterygoid musculature. No infiltration here. Complete involvement of the posterior palatal arch. Exclusion of infiltration towards the nasopharynx. Caudal resection beyond the tonsil lobe and removal of the tumor macroscopically in toto on the specimen. Now removal of marginal samples completely on the specimen. These are completely free of carcinoma, only in the area of the posterior pharyngeal wall is there still circumscribed CIS. A resection is performed here. Overall R0 situation. Now turn to the neck dissection of the left side. Here cN2b neck status. Skin incision at the anterior edge of the sternocleidomastoid muscle. Cut through skin and subcutaneous tissue. Exposure of the sternocleidomastoid muscle. Exposure and later ligation of the external jugular vein. Preservation of the auricular nerve. Exposure of the omohyoid muscle. Release of the submandibular gland and exposure of the digastric muscle. Spinal mass in level II in particular. Release of the anterior neck preparation with careful protection of the superior thyroid artery. Supply and occlusion of the facial vein. Exposure and preservation of the facial and lingual arteries. Exposure of the accessorius nerve, which can be preserved. Free dissection of the internal jugular vein, later completion of the accessorius triangle and level V while carefully preserving the cervical plexus branches, the vagus nerve and the common carotid artery. Finally, the digastric muscle is resected and broken through enorally. Creation of a tunnel measuring 3 transverse fingers. Insertion of moist drapes and turning to the opposite side. The procedure is basically the same here. Incision at the anterior edge of the sternocleidomastoid. Exposure and preservation of the sternocleidomastoid muscle, external jugular vein and auricular nerve. Exposure of the omohyoid muscle, the submandibular gland and the digastric muscle and exposure and preservation of the facial vein, superior thyroid artery, cervical artery and hypoglossal nerve. Clearing out the anterior neck preparation. Exposure of the accessorius nerve. Free preparation of the internal jugular vein. Circumscribed clearing of the accessorius triangle and completion in the direction of level V with careful protection and .............................. of the extent in the direction of the cervical plexus. Exposure and preservation of the common carotid artery and vagus nerve. Subsequent careful wound inspection. Insertion of a 10-gauge Redon drain and careful, two-layer wound closure. Plastic tracheotomy: Horizontal incision at the level of the cricoid cartilage. Cut through the skin and subcutaneous tissue. Exposure of the infrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the thyroid isthmus. Supply of the thyroid isthmus and transection. Insertion between the 2nd and 3rd tracheal ring while performing a visual tracheotomy. Subsequent insertion of the tracheostoma in the usual manner while performing the mucocutaneous anastomosis. Finally, problem-free transfer to a size 8 low-cuff cannula. : First, preparation of the arm. Marking of the radialis graft, which is 12 x 8 cm in size with a bulge for the soft palate duplication. First mark the graft. Marking of the full-thickness skin donor site on the proximal forearm for primary defect coverage at the graft site. Trimming of the full-thickness skin. Lifting the full-thickness skin. Asservation of the full-thickness skin. Incision of the graft and exposure of the brachioradialis muscle. Exposure of the cephalic vein. Exposure of the superficial radial ramus nerve, which splits into two branches. Both branches can be visualized and preserved. Exposure of the radial artery, which is extremely lateral in this patient. Ligation and separation of the radial artery in the distal area. Exposure of the tendon level. Integration of the cephalic vein into the graft. Lifting the graft from the tendons. This reveals the ulnar artery, which can remain completely intact. Lifting of the radialis pedicle in the usual manner. Dissection of the venous star in the crook of the elbow. There is good venous confluence between the superficial and deep venous system. Both a superficial and a deep vein are prepared as a venous connection vessel. Deposition of the graft. Attempt at primary wound closure on the proximal part of the forearm. This is not completely successful. Incision of the full-thickness skin into the graft donor site and residual full-thickness skin coverage in the proximal area of the forearm. Application of Mepilex and sterile wound dressing. Application of a dorsal forearm splint. Insertion of the graft into the defect with doubling of the soft palate through . The stem is diverted to the left. Creation of the vascular anastomosis by , initially on the left side via the stump of the superior thyroid artery. Suturing the anastomosis is very difficult as the flap vessel is covered with cholesterol-containing material and the individual wall layers no longer adhere well to each other. The patency of the flap stalk is difficult. Initially there is an acceptable flow via the superior thyroid artery, which then stops abruptly so that this vascular anastomosis has to be removed again. Unfortunately, there is no longer a corresponding vessel on the left side, as the vessels in question are all calcified or interspersed with whitish material containing cholesterol. A tunnel was therefore created to the right side of the neck. The superior thyroid is shown here. Dissection of this and anastomosis with the flap vessel. Good blood flow can be established. Connection of the venous vessels, once to the facial vein and once to a vein accompanying the facial vein. Control of flap blood flow. Good flap perfusion. If there are signs of compartment syndrome on the left forearm, please consult the surgeon and open the wound. No oral food for 10 days. Then X-ray pre-swallow and oral food build-up. \ No newline at end of file diff --git a/115/InvasionFront_CD3_block2_x3_y7_patient115_0.json b/115/InvasionFront_CD3_block2_x3_y7_patient115_0.json new file mode 100644 index 0000000000000000000000000000000000000000..80a1a030d5a1813408b23d08b1d710f6ff226f31 --- /dev/null +++ b/115/InvasionFront_CD3_block2_x3_y7_patient115_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 30883.6, + "Num Detections": 19081, + "Num Negative": 18706, + "Num Positive": 375, + "Positive %": 1.965, + "Num Positive per mm^2": 178.2 + } +} \ No newline at end of file diff --git a/115/InvasionFront_CD3_block2_x4_y7_patient115_1.json b/115/InvasionFront_CD3_block2_x4_y7_patient115_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e22b4391796b692925515d1665fb2b455b890b2e --- /dev/null +++ b/115/InvasionFront_CD3_block2_x4_y7_patient115_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 30958.6, + "Num Detections": 19019, + "Num Negative": 18678, + "Num Positive": 341, + "Positive %": 1.793, + "Num Positive per mm^2": 164.95 + } +} \ No newline at end of file diff --git a/115/InvasionFront_CD8_block2_x3_y7_patient115_0.json b/115/InvasionFront_CD8_block2_x3_y7_patient115_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c915962fc7cd9a26557fdfcbc5820ce33b866131 --- /dev/null +++ b/115/InvasionFront_CD8_block2_x3_y7_patient115_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12518.4, + "Centroid Y µm": 18615.1, + "Num Detections": 18028, + "Num Negative": 17115, + "Num Positive": 913, + "Positive %": 5.064, + "Num Positive per mm^2": 460.09 + } +} \ No newline at end of file diff --git a/115/InvasionFront_CD8_block2_x4_y7_patient115_1.json b/115/InvasionFront_CD8_block2_x4_y7_patient115_1.json new file mode 100644 index 0000000000000000000000000000000000000000..badb8fe2b38bdfcb6f62db8b6063b16f41b6b194 --- /dev/null +++ b/115/InvasionFront_CD8_block2_x4_y7_patient115_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15167.0, + "Centroid Y µm": 18815.0, + "Num Detections": 17444, + "Num Negative": 16520, + "Num Positive": 924, + "Positive %": 5.297, + "Num Positive per mm^2": 488.14 + } +} \ No newline at end of file diff --git a/115/TumorCenter_CD3_block2_x3_y7_patient115_0.json b/115/TumorCenter_CD3_block2_x3_y7_patient115_0.json new file mode 100644 index 0000000000000000000000000000000000000000..76a1685a353909e19425143b7addc233ea738e79 --- /dev/null +++ b/115/TumorCenter_CD3_block2_x3_y7_patient115_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11294.0, + "Centroid Y µm": 17066.0, + "Num Detections": 15453, + "Num Negative": 14903, + "Num Positive": 550, + "Positive %": 3.559, + "Num Positive per mm^2": 284.98 + } +} \ No newline at end of file diff --git a/115/TumorCenter_CD3_block2_x4_y7_patient115_1.json b/115/TumorCenter_CD3_block2_x4_y7_patient115_1.json new file mode 100644 index 0000000000000000000000000000000000000000..09900dde07c3a2028ec37bb7fcf5ee452fbd01d0 --- /dev/null +++ b/115/TumorCenter_CD3_block2_x4_y7_patient115_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 17240.9, + "Num Detections": 19883, + "Num Negative": 19014, + "Num Positive": 869, + "Positive %": 4.371, + "Num Positive per mm^2": 426.81 + } +} \ No newline at end of file diff --git a/115/TumorCenter_CD8_block2_x3_y7_patient115_0.json b/115/TumorCenter_CD8_block2_x3_y7_patient115_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ef46412fd1e3a2a9a2efae6eecee1709f3c3b447 --- /dev/null +++ b/115/TumorCenter_CD8_block2_x3_y7_patient115_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13043.1, + "Centroid Y µm": 17140.9, + "Num Detections": 15535, + "Num Negative": 15149, + "Num Positive": 386, + "Positive %": 2.485, + "Num Positive per mm^2": 191.07 + } +} \ No newline at end of file diff --git a/115/TumorCenter_CD8_block2_x4_y7_patient115_1.json b/115/TumorCenter_CD8_block2_x4_y7_patient115_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a79ece8f9b3772b7bdc9e6cbfca464b9ad838e7f --- /dev/null +++ b/115/TumorCenter_CD8_block2_x4_y7_patient115_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15641.7, + "Centroid Y µm": 17115.9, + "Num Detections": 19499, + "Num Negative": 16872, + "Num Positive": 2627, + "Positive %": 13.47, + "Num Positive per mm^2": 1299.0 + } +} \ No newline at end of file diff --git a/115/history_text.txt b/115/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..847dd5fd169c8e817e41e4da0d528546ce7f6585 --- /dev/null +++ b/115/history_text.txt @@ -0,0 +1 @@ +An extensive hypopharyngeal carcinoma was histologically confirmed in the patient <2015> as part of a panendoscopy, total cT2 cN2b G3 hypopharyngeal carcinoma on the left. In our interdisciplinary tumor conference, the primary surgical procedure with laryngectomy was recommended. \ No newline at end of file diff --git a/115/icd_codes.txt b/115/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6c803b384690c5bc768ff124953acda1043a466b --- /dev/null +++ b/115/icd_codes.txt @@ -0,0 +1 @@ +Neubildung bösartig Hypopharynx sonstige[C13.8 L] \ No newline at end of file diff --git a/115/ops_codes.txt b/115/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..675c02412267896a851e41d3bd8463bbc11fa245 --- /dev/null +++ b/115/ops_codes.txt @@ -0,0 +1 @@ +Selektive Neck dissection in 4 Regionen[5-403.03 B] Sonstige Laryngektomie mit Pharyngektomie[5-303.1x ] Einfache Laryngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.04 ] Entnahme eines freien Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-904.0e R] Permanente Tracheotomie[5-312.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] \ No newline at end of file diff --git a/115/patient_clinical_data.json b/115/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..201ad3fbea8c665bdb99e895d33a8e15781f841c --- /dev/null +++ b/115/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 39, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/115/patient_pathological_data.json b/115/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..916610c744118598d091df5ccdfe0176823ff4a9 --- /dev/null +++ b/115/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "115", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/115/surgery_description.txt b/115/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6aeaa042f3d6c9483c24392a6beca249bf4c20f8 --- /dev/null +++ b/115/surgery_description.txt @@ -0,0 +1 @@ +Transcervical TU resection with partial pharyngectomy + LE (Laryngectomy), Defect coverage, Free flap (ALT), Functional bilateral neck dissection diff --git a/115/surgery_report.txt b/115/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1426242130fb46071e688de706bdef4bfd99feb7 --- /dev/null +++ b/115/surgery_report.txt @@ -0,0 +1 @@ +Dictation : After induction of anesthesia and intubation by the anesthesia colleagues, the primary tumor region is first inspected. After entering with the Kleinsasser tube, the exophytic and ulcerated tumor is already visible in the area caudal to the left tonsil, spreading caudally over the lateral pharyngeal wall and extending into the piriform sinus, filling it completely and extending over the anterior wall and into the medial wall, infiltrating the larynx. Therefore confirmation of the indication for laryngectomy. Free postcricoid and esophageal entrance. The entire right side is also tumor-free, but due to the elongated, broad tumor course in the area of the pharyngeal side wall, reconstruction is probably required. A nasogastric feeding tube is now inserted under visualization. Repositioning of the patient. Lifting of an apron flap by cutting through the skin and subcutaneous tissue. Dissection and cranial preparation of the platysma. Start with neck dissection of the right side. Dissection of the sternocleidomastoid muscle and preservation of the external jugular vein. Exposure of the omohyoid muscle. Release of the submandibular gland and exposure of the digastric muscle. Clearing of the anterior neck preparation with careful protection of the hypoglossal nerve and superior thyroid artery. A true facial vein does not exist. Free preparation of the internal jugular vein. Cranial exposure of the accessorius nerve. Clearing of the posterior neck area with careful protection and exposure of the cervical plexus roots. Macroscopically no conspicuous nodules here. Careful hemostasis. Turning to the opposite side. Now the same primary procedure on the left side. Exposure of the sternocleidomastoid muscle while preserving the external jugular vein. Free preparation of the sternocleidomastoid muscle, omohyoid muscle. Release of the submandibular gland and exposure of the digastric muscle. Clearing out the anterior neck preparation while carefully protecting the superior thyroid artery, hypoglossal nerve and the slender facial vein. Complete the neck dissection after exposing the accessory nerve in the case of conspicuous nodes in the jugular-facial angle, exposing the cervical plexus roots, the common carotid artery and the vagus nerve corresponding to the opposite side on the left. Resection up to level V b. Careful check for lymphatic leakage. Dry conditions here. Careful hemostasis. Turn to tumor resection. Detachment of the infrahyoid musculature. Skeletonization of the larynx on the right side. Careful and complete release of the piriform sinus. On the left side, the attempt to detach the thyroid cartilage horn already reveals an adhesion or direct adherence to the tumor; if partially opened here, the suture is marked in the sense of a suture closure for later marking and covering of the margins. Skeletonize the cricoid cartilage and trachea while exposing and detaching the thyroid gland. Now enter enorally in the area of the vallecula on the right side, widen along the aryepiglottic fold and proceed in a mucosa-sparing manner. After widening the pharyngotomy, a good overview is now obtained. As described above, the tumor infiltrates caudal to the tonsil. Incision with a safety margin. Somewhat vulnerable conditions in the area of the glossotonsillar groove, otherwise macroscopically all around in sano incision of the tumor. Good control of the deep infiltration. Supply and removal of the lingual artery on the left side. Largely sparing of the postcricoid mucosa and removal of the tumor macroscopically in sano. The marginal specimen is now largely removed from the specimen. The site already described in the area of the thyroid cartilage horn on the left or the pharyngeal side wall here is additionally covered in the area of the soft tissue. In addition, in situ marginal sampling of the described vulnerable area completely in the base of the tongue up to the tonsil lobe. In the frozen section diagnostics, all tumor samples are now diagnosed as dysplasia and carcinoma-free, therefore an R0 situation can be assumed here. Careful hemostasis. Dictation : Defect reconstruction. Inspection of the defect. There is a hypopharyngeal defect starting at the soft palate up to the esophageal entrance. More than half of the pharyngeal mucosa is missing on the soft palate and in the upper part of the hypopharynx. Primary suturing is not possible in this area. A quarter to a third is missing in the distal area at the entrance to the esophagus. Primary suturing is still acceptable here. Decision to reconstruct the defect with an anterolateral transfemoral graft from the right. Intraoperative demo again to . Then turn to the thigh. First Doppler the perforating vessels. Five good perforator vessels can be identified, three of which can be claimed as main perforators. Mark the graft 12 x 7 cm so that the doubled perforator vessels are centrally located in the area of the graft. Incise the upper edge. Expose the fascia and the rectus femoris muscle. Exposure of the intermedius muscle and the sulcus. Exposing the descending ramus, the circumflex femoral artery and locating the outlets of the perforating vessels. This was successful without any problems. The perforating vessels are dissected from the pedicle to the periphery in the direction of the muscle and skin. Cut around the entire graft and remove the distal end of the stalk. Then develop the graft while protecting the perforator vessels. Some muscle is left around the perforator vessels on the posterior surface. Deposit the pedicle relatively far proximally. A good artery and two veins can be elevated. The nerve is severed. Bipolar coagulation. Insertion of a Redon drain and direct wound closure in the area of the thigh. Now turn to the pharyngeal defect. First conditioning of blood vessels. The vascular situation is very poor. There is only a stump of the superior thyroid on both sides. There is virtually nothing left of the venous connecting vessels except for an external jugular vein and the internal jugular vein. The stump of the superior thyroid on the left side is conditioned as well as the external and internal jugular veins. First fitting of the transplant. Sutures are placed in the area of the oropharynx and hypopharynx on the left side. Suturing in the graft. This is very difficult as the patient cannot recline the head and the graft has to be inserted very far cranially on the soft palate and at the base of the tongue. Finally, complete pharyngeal closure by the graft and primary pharyngeal suture in the distal area. Then conditioning of the flap vessels and start with the anastomosis of the artery. This is successful without any problems. Then anastomosis of the external jugular vein with a graft vein. This is very difficult due to a large difference in caliber. This difference in caliber can only be partially compensated for by cutting the graft vein at an angle. Another vein must be placed end-to-side on the left internal jugular vein. This is also not easy. In the end, very good pedicle pulsation and extremely good reflux in the veins. At the end, the tracheostoma is sutured. The apron flap is folded back. Redon drains inserted beforehand. Graft control from transorally. Good graft perfusion here. The patient goes to the intensive care unit ventilated. Please continue 3 x 3 g Unacid for 24 hours postoperatively as well as daily flap checks according to the usual schedule. \ No newline at end of file diff --git a/116/InvasionFront_CD3_block1_x5_y4_patient116_0.json b/116/InvasionFront_CD3_block1_x5_y4_patient116_0.json new file mode 100644 index 0000000000000000000000000000000000000000..de4addf5c5c00ff74d2d983cf91716cb4519f044 --- /dev/null +++ b/116/InvasionFront_CD3_block1_x5_y4_patient116_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16816.1, + "Centroid Y µm": 11918.7, + "Num Detections": 20251, + "Num Negative": 19631, + "Num Positive": 620, + "Positive %": 3.062, + "Num Positive per mm^2": 258.57 + } +} \ No newline at end of file diff --git a/116/InvasionFront_CD3_block1_x6_y4_patient116_1.json b/116/InvasionFront_CD3_block1_x6_y4_patient116_1.json new file mode 100644 index 0000000000000000000000000000000000000000..86a44aec0ff5961c457a0cf320174612f92f76d5 --- /dev/null +++ b/116/InvasionFront_CD3_block1_x6_y4_patient116_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19414.7, + "Centroid Y µm": 11993.6, + "Num Detections": 20006, + "Num Negative": 19593, + "Num Positive": 413, + "Positive %": 2.064, + "Num Positive per mm^2": 174.06 + } +} \ No newline at end of file diff --git a/116/InvasionFront_CD8_block1_x5_y4_patient116_0.json b/116/InvasionFront_CD8_block1_x5_y4_patient116_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e6c264e9d93140add4e146622c0176a2f0cdc659 --- /dev/null +++ b/116/InvasionFront_CD8_block1_x5_y4_patient116_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16916.0, + "Centroid Y µm": 10694.3, + "Num Detections": 17431, + "Num Negative": 17087, + "Num Positive": 344, + "Positive %": 1.973, + "Num Positive per mm^2": 154.74 + } +} \ No newline at end of file diff --git a/116/InvasionFront_CD8_block1_x6_y4_patient116_1.json b/116/InvasionFront_CD8_block1_x6_y4_patient116_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c51b40630e6db9ce1465014c0e88e6bec57a3088 --- /dev/null +++ b/116/InvasionFront_CD8_block1_x6_y4_patient116_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19439.7, + "Centroid Y µm": 10819.3, + "Num Detections": 19757, + "Num Negative": 19334, + "Num Positive": 423, + "Positive %": 2.141, + "Num Positive per mm^2": 181.81 + } +} \ No newline at end of file diff --git a/116/TumorCenter_CD3_block1_x5_y6_patient116_0.json b/116/TumorCenter_CD3_block1_x5_y6_patient116_0.json new file mode 100644 index 0000000000000000000000000000000000000000..66964af9578bcc199c9ff68fc0920fb93f81a15f --- /dev/null +++ b/116/TumorCenter_CD3_block1_x5_y6_patient116_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15791.6, + "Centroid Y µm": 14942.1, + "Num Detections": 15799, + "Num Negative": 15241, + "Num Positive": 558, + "Positive %": 3.532, + "Num Positive per mm^2": 261.36 + } +} \ No newline at end of file diff --git a/116/TumorCenter_CD3_block1_x6_y6_patient116_1.json b/116/TumorCenter_CD3_block1_x6_y6_patient116_1.json new file mode 100644 index 0000000000000000000000000000000000000000..097865a02929bcb74401a1c3c6233d7c39255d30 --- /dev/null +++ b/116/TumorCenter_CD3_block1_x6_y6_patient116_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18365.3, + "Centroid Y µm": 14767.2, + "Num Detections": 14518, + "Num Negative": 14165, + "Num Positive": 353, + "Positive %": 2.431, + "Num Positive per mm^2": 177.9 + } +} \ No newline at end of file diff --git a/116/TumorCenter_CD8_block1_x5_y4_patient116_0.json b/116/TumorCenter_CD8_block1_x5_y4_patient116_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e33a9ef3c6c3d8efa268288fc6d77d7e0df39513 --- /dev/null +++ b/116/TumorCenter_CD8_block1_x5_y4_patient116_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 18790.1, + "Num Detections": 19956, + "Num Negative": 19832, + "Num Positive": 124, + "Positive %": 0.6214, + "Num Positive per mm^2": 52.09 + } +} \ No newline at end of file diff --git a/116/TumorCenter_CD8_block1_x6_y4_patient116_1.json b/116/TumorCenter_CD8_block1_x6_y4_patient116_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fc03c5347e9427135e2c14a92dba1256509cd0b7 --- /dev/null +++ b/116/TumorCenter_CD8_block1_x6_y4_patient116_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21313.7, + "Centroid Y µm": 18690.1, + "Num Detections": 17477, + "Num Negative": 17264, + "Num Positive": 213, + "Positive %": 1.219, + "Num Positive per mm^2": 90.57 + } +} \ No newline at end of file diff --git a/116/history_text.txt b/116/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/116/icd_codes.txt b/116/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..da55c7511d068fc0b0dfe7e6a45d4d38eecf0a89 --- /dev/null +++ b/116/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/116/ops_codes.txt b/116/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..942bc46fab6bc4fd05befc27858b5e3e250eff45 --- /dev/null +++ b/116/ops_codes.txt @@ -0,0 +1 @@ +Permanente Tracheostomaanlage[5-312.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/116/patient_clinical_data.json b/116/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..82b4189058b2e91e13ddb80aa7961ab17a1153b4 --- /dev/null +++ b/116/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/116/patient_pathological_data.json b/116/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4e4aa4d0c545e218392d6e38251f77c691663ab6 --- /dev/null +++ b/116/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "116", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 11, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/116/surgery_description.txt b/116/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..13cd59a5e9f96b7cd7c6a409a58c4f230555a8c8 --- /dev/null +++ b/116/surgery_description.txt @@ -0,0 +1 @@ +Uvula partial resection, Panendoscopy diff --git a/116/surgery_report.txt b/116/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..829e1c7ed3d026d02e0c53e0aaba7c8da88b162c --- /dev/null +++ b/116/surgery_report.txt @@ -0,0 +1 @@ +At the beginning of the procedure, laryngoscopic adjustment of the glottic plane after induction of intubation anesthesia. This is extremely difficult with poor mouth opening and poor hyperextensibility of the neck. With Cormack III, an inspection of the upper parts of the trachea with 0° optics is possible. The glottis is non-irritating and unremarkable. The patient is then intubated by the surgeon with great effort. Overall difficult airway. The esophagus is then inspected as part of flexible esophagogastroscopy. It is extremely difficult to enter the upper esophageal sphincter in the case of esophageal cancer and radiation. Finally, the flexible instrument can be advanced with difficulty up to 20 cm from the tooth row. This reveals a web-like stenosis of the esophagus that cannot be overcome by the flexible endoscope. In this case, if the patient has undergone pre-treatment and has a malignant tumor, no forced attempt is made, so that esophagoscopy is only performed up to 20 cm from the tooth row and the distal parts of the esophagus can then no longer be inspected. Removal of the esophagoscope. Now reposition the patient and inspect the oral cavity and oropharynx as well as the hypopharyngeal and laryngeal skeleton. In the hypopharyngeal and laryngeal region, the mucosal conditions are unremarkable. In the area of the oropharynx, an exophytic mass can be seen in the area of the glossotonsillar groove. The tongue is clearly fixed and the posterior part is clearly scarred and hardened. The tongue is then sutured and an oral retractor inserted. If the findings are histologically confirmed externally, resection begins from the anterior margin with a safety margin of around 5 mm. The resection extends into the body of the tongue. It can be seen here that the tumor has clearly grown submucosally into the body of the tongue and into the base of the tongue. Two large tumor necrosis cavities can be seen here. The external CT is superimposed by massive artifacts, so that this area could not be evaluated. The overall extent of the tumor thus proved to be much larger than estimated preoperatively. The tumor is then incised with an electric needle. Care is taken to maintain a safety margin of around 5 mm. After the body of the tongue can be mobilized better with increasing resection, it becomes apparent that the tumour is spreading to the tonsil lobe. Therefore, resection up to the alveolar ridge at the back of the posterior molars up to the tonsillar lobe. The resection extends from here to the anterior and posterior palatal arch. The preparation is then sent for histological examination. Subsequently, marginal samples are taken from all representative areas of deposition. Subsequent subtle hemostasis. The tumor is macroscopically and palpatorily distant from the healthy tissue. If the wound is dry, infiltrate bupivacaine into the body of the tongue. As the wound area is now clearly extensive and the patient has a restricted airway and therefore a significantly impaired airway, is consulted and an intraoperative discussion regarding tracheostomy is held. A consensus was reached to perform a small tracheostomy in the sense of a protective tracheostomy. Wound check again. Removal of the mouth block and loosening of the tongue retaining suture. Then injection of local anesthetic with adrenaline in front of the trachea. Transverse skin incision and layered preparation in depth. Separation of the platysma. Separation of the prelaryngeal muscles. Layered dissection in depth. Exposure of the thyroid isthmus. This is undermined and stitched around on both sides after it has been severed. Exposure of the anterior surface of the trachea. Now incise the trachea between the second and third cartilage clasp. Preparation of a Björk flap. Circular suturing of the tracheostoma. Then reintubation to an 8 mm tracheal cannula with a large tracheal lumen. This was successful without any problems. Then dressing and fixation of the cannula. Final enoral check. Dry wound conditions. The patient is transferred to the in-house intensive care unit for safety and monitoring. This concludes the procedure. Postoperatively, the patient's swallowing function must now be monitored. The patient is not yet neck-dissected on the left side, so that depending on the functional result, treatment and defect coverage using a radial flap is still possible here. \ No newline at end of file diff --git a/117/InvasionFront_CD3_block18_x1_y1_patient117_0.json b/117/InvasionFront_CD3_block18_x1_y1_patient117_0.json new file mode 100644 index 0000000000000000000000000000000000000000..325d287a15230ca8ba646290cf493586f1cae37d --- /dev/null +++ b/117/InvasionFront_CD3_block18_x1_y1_patient117_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4822.4, + "Centroid Y µm": 6371.6, + "Num Detections": 22543, + "Num Negative": 20461, + "Num Positive": 2082, + "Positive %": 9.236, + "Num Positive per mm^2": 857.17 + } +} \ No newline at end of file diff --git a/117/InvasionFront_CD3_block18_x2_y1_patient117_1.json b/117/InvasionFront_CD3_block18_x2_y1_patient117_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4dc4dfa76277e70d6a89dce4e935c9ac6468dd72 --- /dev/null +++ b/117/InvasionFront_CD3_block18_x2_y1_patient117_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7296.1, + "Centroid Y µm": 6696.5, + "Num Detections": 12979, + "Num Negative": 12386, + "Num Positive": 593, + "Positive %": 4.569, + "Num Positive per mm^2": 404.91 + } +} \ No newline at end of file diff --git a/117/InvasionFront_CD8_block18_x1_y1_patient117_0.json b/117/InvasionFront_CD8_block18_x1_y1_patient117_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3a12a424131f50524e38dddf4e3a349cdea2fa3d --- /dev/null +++ b/117/InvasionFront_CD8_block18_x1_y1_patient117_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4472.6, + "Centroid Y µm": 10544.4, + "Num Detections": 23184, + "Num Negative": 21221, + "Num Positive": 1963, + "Positive %": 8.467, + "Num Positive per mm^2": 747.46 + } +} \ No newline at end of file diff --git a/117/InvasionFront_CD8_block18_x2_y1_patient117_1.json b/117/InvasionFront_CD8_block18_x2_y1_patient117_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ec241cbdd8db4530e1324a05bc7dcfc7df4227dc --- /dev/null +++ b/117/InvasionFront_CD8_block18_x2_y1_patient117_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6896.3, + "Centroid Y µm": 10569.4, + "Num Detections": 19450, + "Num Negative": 18938, + "Num Positive": 512, + "Positive %": 2.632, + "Num Positive per mm^2": 230.18 + } +} \ No newline at end of file diff --git a/117/TumorCenter_CD3_block18_x1_y1_patient117_0.json b/117/TumorCenter_CD3_block18_x1_y1_patient117_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e4e8f6e23007d0e521f984555064aa63d371bb0f --- /dev/null +++ b/117/TumorCenter_CD3_block18_x1_y1_patient117_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4017.7, + "Centroid Y µm": 2360.0, + "Num Detections": 15121, + "Num Negative": 14628, + "Num Positive": 493, + "Positive %": 3.26, + "Num Positive per mm^2": 225.69 + } +} \ No newline at end of file diff --git a/117/TumorCenter_CD3_block18_x2_y1_patient117_1.json b/117/TumorCenter_CD3_block18_x2_y1_patient117_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7ff9bad0cca48f04254da7db2da421e37bcef195 --- /dev/null +++ b/117/TumorCenter_CD3_block18_x2_y1_patient117_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 2373.6, + "Num Detections": 12559, + "Num Negative": 12455, + "Num Positive": 104, + "Positive %": 0.8281, + "Num Positive per mm^2": 69.84 + } +} \ No newline at end of file diff --git a/117/TumorCenter_CD8_block18_x1_y1_patient117_0.json b/117/TumorCenter_CD8_block18_x1_y1_patient117_0.json new file mode 100644 index 0000000000000000000000000000000000000000..665600b0d9bc251a9afe564cb9dfa4fe93b19931 --- /dev/null +++ b/117/TumorCenter_CD8_block18_x1_y1_patient117_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 2623.6, + "Num Detections": 17603, + "Num Negative": 16291, + "Num Positive": 1312, + "Positive %": 7.453, + "Num Positive per mm^2": 565.89 + } +} \ No newline at end of file diff --git a/117/TumorCenter_CD8_block18_x2_y1_patient117_1.json b/117/TumorCenter_CD8_block18_x2_y1_patient117_1.json new file mode 100644 index 0000000000000000000000000000000000000000..abbb9e2f1b821cd43ead97fed42e3e0c8bb5aa49 --- /dev/null +++ b/117/TumorCenter_CD8_block18_x2_y1_patient117_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 2773.5, + "Num Detections": 18161, + "Num Negative": 16814, + "Num Positive": 1347, + "Positive %": 7.417, + "Num Positive per mm^2": 617.2 + } +} \ No newline at end of file diff --git a/117/history_text.txt b/117/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1a73c940379199783d958f7235a49074b4add1bb --- /dev/null +++ b/117/history_text.txt @@ -0,0 +1 @@ +A cT1a glottic carcinoma of the left side was histologically confirmed in the patient, hence the indication for the above-mentioned procedure. \ No newline at end of file diff --git a/117/icd_codes.txt b/117/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/117/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/117/ops_codes.txt b/117/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3815c9ad86b1d0b850c5271aa4ef7fc96f387653 --- /dev/null +++ b/117/ops_codes.txt @@ -0,0 +1 @@ +Endolaryngeale Chordektomie[5-302.1 ] \ No newline at end of file diff --git a/117/patient_clinical_data.json b/117/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2607a76fdb3dd7071454e62c50ad8db592b96e3d --- /dev/null +++ b/117/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/117/patient_pathological_data.json b/117/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b914f8e764bea79129fffa7b6da5166c28f9d8a1 --- /dev/null +++ b/117/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "117", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 0.5 +} \ No newline at end of file diff --git a/117/surgery_description.txt b/117/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc04890838f57139baab64a44769ec5870b37170 --- /dev/null +++ b/117/surgery_description.txt @@ -0,0 +1 @@ +Microscopic laser resection diff --git a/117/surgery_report.txt b/117/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1bb0de8db5d0649c2f68f8e1de42fb8e1aa3694d --- /dev/null +++ b/117/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is taken to the operating theater. Induction of anesthesia and intubation (laser tube) by the anesthesia colleagues. Positioning of the patient by the surgeon. Setting up the C02 laser. Adjustment of the endolarynx with the size B small bore tube. A cT1a glottic carcinoma is seen on the left, which completely occupies the middle and anterior third of the vocal fold and extends to just behind the anterior commissure on the left side, but does not extend into it. In terms of width and height, it extends approx. 3 mm down the subglottic slope. It does not extend into the sinus morgagni. Now mark the resectate borders with the CO2 laser superpulsed to 4 watts continuous wave. Then resection of the tumor from posterior to anterior with a safety margin of approx. 2 mm to the depth and edges. Minor bleeding in the area of the anterior commissure, which is coagulated with the D-focused CO2 laser and the bipolar forceps. Subsequent margin samples anterior commissure, free vocal fold margin and caudal wound margin including the posterior resectate margin. R0 situation in the frozen section. Therefore, light smoothing of the wound edges with tongues and scissors in the area of the free vocal fold margin. With dry conditions, the operation was then completed without complications. Conclusion: R0 resection of a cT1a glottic carcinoma on the left side with the CO2 laser in a frozen section. Further procedure after receipt of the histology. \ No newline at end of file diff --git a/118/InvasionFront_CD8_block6_x3_y12_patient118_0.json b/118/InvasionFront_CD8_block6_x3_y12_patient118_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fdffdd06882bdbcef2342fc3cfc3ead134027aa7 --- /dev/null +++ b/118/InvasionFront_CD8_block6_x3_y12_patient118_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11269.0, + "Centroid Y µm": 30358.9, + "Num Detections": 18768, + "Num Negative": 13811, + "Num Positive": 4957, + "Positive %": 26.41, + "Num Positive per mm^2": 2053.8 + } +} \ No newline at end of file diff --git a/118/InvasionFront_CD8_block6_x4_y12_patient118_1.json b/118/InvasionFront_CD8_block6_x4_y12_patient118_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ecae4cda3e6836e37539e962678ba8931eebc619 --- /dev/null +++ b/118/InvasionFront_CD8_block6_x4_y12_patient118_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 30458.9, + "Num Detections": 16905, + "Num Negative": 13199, + "Num Positive": 3706, + "Positive %": 21.92, + "Num Positive per mm^2": 1495.4 + } +} \ No newline at end of file diff --git a/118/TumorCenter_CD3_block6_x3_y12_patient118_0.json b/118/TumorCenter_CD3_block6_x3_y12_patient118_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2a5c5cdb80a40a83b7d5cbefa12a3cdcd8282cea --- /dev/null +++ b/118/TumorCenter_CD3_block6_x3_y12_patient118_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 30408.9, + "Num Detections": 21800, + "Num Negative": 13271, + "Num Positive": 8529, + "Positive %": 39.12, + "Num Positive per mm^2": 3497.6 + } +} \ No newline at end of file diff --git a/118/TumorCenter_CD3_block6_x4_y12_patient118_1.json b/118/TumorCenter_CD3_block6_x4_y12_patient118_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fad64b278d77eb2216f41b95ee54906f9d1d59a4 --- /dev/null +++ b/118/TumorCenter_CD3_block6_x4_y12_patient118_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 30383.9, + "Num Detections": 19196, + "Num Negative": 12850, + "Num Positive": 6346, + "Positive %": 33.06, + "Num Positive per mm^2": 2686.7 + } +} \ No newline at end of file diff --git a/118/TumorCenter_CD8_block6_x3_y12_patient118_0.json b/118/TumorCenter_CD8_block6_x3_y12_patient118_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5359a22f8cae6f377e4255d4d01af42439e67013 --- /dev/null +++ b/118/TumorCenter_CD8_block6_x3_y12_patient118_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 30833.7, + "Num Detections": 21472, + "Num Negative": 13958, + "Num Positive": 7514, + "Positive %": 34.99, + "Num Positive per mm^2": 3054.8 + } +} \ No newline at end of file diff --git a/118/TumorCenter_CD8_block6_x4_y12_patient118_1.json b/118/TumorCenter_CD8_block6_x4_y12_patient118_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f693578bd02b305960a9b44194b3ad7c7c072e7 --- /dev/null +++ b/118/TumorCenter_CD8_block6_x4_y12_patient118_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 30883.6, + "Num Detections": 20838, + "Num Negative": 15138, + "Num Positive": 5700, + "Positive %": 27.35, + "Num Positive per mm^2": 2364.6 + } +} \ No newline at end of file diff --git a/118/history_text.txt b/118/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a59cdbdddacfaa1f59d6257a2510458783722749 --- /dev/null +++ b/118/history_text.txt @@ -0,0 +1 @@ +The patient's right oropharyngeal carcinoma cT3 cN2c was histologically confirmed during a panendoscopy. The primary surgical procedure was decided in our interdisciplinary tumor conference. \ No newline at end of file diff --git a/118/icd_codes.txt b/118/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/118/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/118/ops_codes.txt b/118/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4a8ed9d18b1dc6c416228eae8f80482241e9d479 --- /dev/null +++ b/118/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-296.14 ] Partielle Glossektomie durch Pharyngotomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.22 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/118/patient_clinical_data.json b/118/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1e03bcf07ecffe8aeeeb5023fd34eab568a7c972 --- /dev/null +++ b/118/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/118/patient_pathological_data.json b/118/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f2fe85f7efc194e71a81a1c45874d0993ab6aa1b --- /dev/null +++ b/118/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "118", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 27.0 +} \ No newline at end of file diff --git a/118/surgery_description.txt b/118/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..92d0e7f93922372f34aa52a916462abc8ada8be4 --- /dev/null +++ b/118/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Free flap coverage (Radial), Bilateral neck dissection diff --git a/118/surgery_report.txt b/118/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a17fd16dfdb88b1829b56d4e8b7d04912fd9dc43 --- /dev/null +++ b/118/surgery_report.txt @@ -0,0 +1 @@ +First, after transnasal intubation and preparation by the anesthesia colleagues, positioning of the patient. First perform a pharyngoscopy. Enter with the small bore tube. Inspection of the inconspicuous oral cavity. A tumorous, exophytic area can now be seen, starting in the area of the tonsil lobe, which passes over the glossotonsillar groove into the base of the tongue, infiltrates the posterior floor of the mouth submucosally and extends caudally towards the pharyngoepiglottic fold. Overall, a well-defined tumor process. On palpation, however, the extensive submucosal growth from the posterior floor of the mouth and pharyngeal side wall towards the cervical region is conspicuous. Extensive tumor masses here. Transoral resection of the tumor is therefore performed first. Release of the paratonsillar tonsil ligament, initially leaving the posterior palatal arch intact. However, this is later resected transcervically. Widening of the safety margin. Resection up to the buccal. Release of the glossotonsillar groove and the posterior edge of the tongue. Resection towards the base of the tongue. Here, however, significant deep growth and submucosal growth. Therefore, the soft palate, the cheek, the posterior floor of the mouth and the edge of the tongue are now covered. These are assessed as completely free of carcinoma. Therefore, if there is extensive submucosal growth in the area of the floor of the mouth and the side wall of the pharynx, reposition for further transcervical resection. First make the skin incision, curved at the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Exposure and preservation of the external jugular vein. Dissection of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digastric muscle. Release of the anterior neck preparation with careful protection of the superior thyroid artery, which is relatively strong here, the hypoglossal nerve and the cervical vein. Free preparation of the internal jugular vein. Here a few lymph nodes that are not necessarily suspicious macroscopically. Exposure of the accessor nerve. A round, rough and highly suspicious mass measuring approx. 3 x 3 cm can be seen below the accessorius nerve. Resection of the mass with careful protection of the nerve and preservation of the cervical plexus branches. Complete the accessorius triangle and level V while carefully preserving the nerve branches. Subsequent release of the submandibular gland. Exposure of the facial artery and vein first, later both are ligated and removed during the extension of the tumor resection. Complete exposure of the hypoglossal nerve. Resection of the digastric muscle. At the posterior margin of the submandibular gland, the submucosal part of the tumor is already visible. Clear tumor cone towards the cervical region. Widen the safety margin. Involvement of the posterior floor of mouth muscles. Entering enorally via the posterior floor of the mouth. Palpation now reveals a massive tumor block extending caudally over the lateral pharyngeal wall. Hence skeletonization of the hypoglossal nerve. Visualization of the cervical vascular sheath. Exposure of the prevertebral fascia from the cervical vascular sheath. This allows good mobilization of the tumour. Incision of the tumor with a safety margin and resection of the tumor including the posterior floor of mouth muscles and the pharyngeal side wall with a safety margin of a good 1 cm. Macroscopically clearly complete resection. Macroscopically slightly scarce conditions in the area of the posterior floor of the mouth with submucosal growth, but free marginal samples. Completely imaged margin samples are then taken. These are classified as completely tumor-free in the frozen section diagnostics. Finally, an extensive defect of the pharyngeal side wall with approx. 1/3 resection of the right-sided tongue base and resection of the posterior soft palate to parauvular, additional resection of the right tongue edge and the posterior floor of the mouth was found. Therefore, a graft of up to 13 x 10 cm in total is measured. First, however, the neck is dissected on the left side. Curved skin incision on the front edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Here in the cranial area after a previous operation with scarring. Exposure of the auricular nerve. An external jugular vein is not visible here. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the superior thyroid artery, the hypoglossal nerve and the facial vein. Free preparation of the internal jugular vein. Here a few macroscopically not necessarily suspicious masses. Exposure and preservation of the accessorius nerve. Release of the accessorius triangle with careful protection of the nerve and removal of level V with protection of the cervical plexus branches. Final wound inspection. If the wound is dry, wound irrigation, insertion of a 10 Redon drain and two-layer wound closure. The radialis graft is now removed from the left forearm and the plastic tracheotomy is performed in parallel. Firstly, the tracheotomy: After making a skin incision at the lower edge of the cricoid cartilage, cut through the skin and subcutaneous tissue. Exposure and transection of the infrahyoid muscles. Exposure of the cricoid cartilage. This is relatively deep. Exposure of the anterior surface of the trachea. Exposure of the thyroid isthmus. Dissection after ligation and coagulation. Exposure of the anterior surface of the trachea with a low trachea. Insertion between the 1st and 2nd tracheal ring. Creation of a broad-based pedicled Björk flap and insertion of the tracheostoma. Subsequent intubation with an 8-gauge Rüsch cannula, which is suture-fixed. Now to lift the radialis graft from the left: After marking the graft with a special configuration for the soft palate and base of the tongue, start with a tourniquet. Incision of the graft. Due to the size of the graft, a monitor is not lifted. First expose and remove the cephalic vein. Performing the...... ........ Maneuver to identify the ramus superficialis nervi radialis. Identification and visualization of the distal vascular pedicle. Cut after ligation. Ulnar release strictly subfascial with careful protection of the superficial ulnar artery, which is completely spared including the perivascular tissue. Strictly subfascial release of the specimen with release of the vascular pedicle. A small, medially pulling branch of the superficial radial nerve ramus must be resected, but the main trunk must be preserved. Proximal dissection with clipping of the descending pedicle vessels. Expose the brachial artery in the crook of the elbow with the exit of the powerful ulnar artery. The common interosseous artery arises here from the ulnar artery, therefore the radial artery can be dissected up to the brachial artery. There is a strong confluence of the accompanying radial veins here, but no bridge to the cephalic vein, so this is removed later. During the dissection, the massive truncal adiposity leads to insufficiency of the tourniquet. The tourniquet is therefore released again after approx. 20 minutes of preparation time. Elevation of the graft without blood lock without any problems. All-round vitality of the graft and regular blood supply to the hand until the graft is removed. Subsequent careful wound inspection. Hemostasis. Careful, two-layer wound closure and insertion of the full-thickness skin graft lifted from the right thigh. Subsequent application of the vacuum pump and application of the Kramer splint in the functional position and repositioning of the arm. Removal of the full-thickness skin graft: This is done in the case of pronounced fatty degeneration of the trunk. Removal of a full-thickness skin graft measuring approx. 16 x 8 cm. Resection of protruding, extremely large ......... fatty tissue. Resection of subcutaneous fatty tissue until multi-layer wound closure is possible without problems under moderate tension conditions. Prior to this, insertion of a 10 Redon drain. The graft is then inserted transorally and transcervically: this is laborious due to the size of the defect, but is ultimately successful with good reconstruction of the soft palate and extensive pharyngectomy. Reconstruction of the base and edge of the tongue. Regular check of fit and integrity. Subsequent conditioning of the flap vessels. Conditioning of the superior thyroid artery and the facial vein, which has excellent flow close to the outlet. Perform the arterial anastomosis with 8-0 Ethilon. This succeeds adequately. Immediate regular venous return flow with regular graft perfusion. Measurement of a size 3.5 coupler and insertion of the venous anastomosis with the coupler system. Subsequently, regular flow and excellent flap vitality. Subsequently, to protect against kinking, circumscribed suture fixation of the stalk course. Subsequent insertion of a guided 10 Redon drain and two-layer wound closure. Repositioning of the patient and completion of the procedure at this point without any indication of complications. The patient received intraoperative intravenous antibiotics with Unacid 3 g, which should be continued for at least 2 to 3 days postoperatively. Conclusion: Intraoperative R0-resected at least cT3 cN2b oropharyngeal carcinoma on the right with locally aggressive and extensive submucosal growth. Transcervical, complete removal of the basal tumor area. Postoperatively, please perform an X-ray gruel swallow on the 8th to 9th postoperative day with regular flap vitality. Due to the muscular deficit, prolonged swallowing rehabilitation is to be expected. \ No newline at end of file diff --git a/119/InvasionFront_CD3_block10_x3_y11_patient119_0.json b/119/InvasionFront_CD3_block10_x3_y11_patient119_0.json new file mode 100644 index 0000000000000000000000000000000000000000..033c3aa419668f05585ad3ba86085aa51d68d545 --- /dev/null +++ b/119/InvasionFront_CD3_block10_x3_y11_patient119_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11774.1, + "Centroid Y µm": 33406.0, + "Num Detections": 10187, + "Num Negative": 10018, + "Num Positive": 169, + "Positive %": 1.659, + "Num Positive per mm^2": 110.54 + } +} \ No newline at end of file diff --git a/119/InvasionFront_CD3_block10_x4_y11_patient119_1.json b/119/InvasionFront_CD3_block10_x4_y11_patient119_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4ddf2332899a797815739db86324aa6d239cf897 --- /dev/null +++ b/119/InvasionFront_CD3_block10_x4_y11_patient119_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14022.0, + "Centroid Y µm": 33655.9, + "Num Detections": 17293, + "Num Negative": 17251, + "Num Positive": 42, + "Positive %": 0.2429, + "Num Positive per mm^2": 18.94 + } +} \ No newline at end of file diff --git a/119/InvasionFront_CD8_block10_x3_y11_patient119_0.json b/119/InvasionFront_CD8_block10_x3_y11_patient119_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee29fb4316a9a3e8f83499286ae892ba69190a8d --- /dev/null +++ b/119/InvasionFront_CD8_block10_x3_y11_patient119_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12393.4, + "Centroid Y µm": 33857.1, + "Num Detections": 12628, + "Num Negative": 12432, + "Num Positive": 196, + "Positive %": 1.552, + "Num Positive per mm^2": 122.23 + } +} \ No newline at end of file diff --git a/119/InvasionFront_CD8_block10_x4_y11_patient119_1.json b/119/InvasionFront_CD8_block10_x4_y11_patient119_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e65f6fe7b67ada4a4b0279e48e65c19a7295e19e --- /dev/null +++ b/119/InvasionFront_CD8_block10_x4_y11_patient119_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14892.1, + "Centroid Y µm": 34032.0, + "Num Detections": 19809, + "Num Negative": 19771, + "Num Positive": 38, + "Positive %": 0.1918, + "Num Positive per mm^2": 15.88 + } +} \ No newline at end of file diff --git a/119/TumorCenter_CD3_block10_x3_y11_patient119_0.json b/119/TumorCenter_CD3_block10_x3_y11_patient119_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bd37711689dfeae681ea402ebea54e52fc37b0a7 --- /dev/null +++ b/119/TumorCenter_CD3_block10_x3_y11_patient119_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 26885.8, + "Num Detections": 5077, + "Num Negative": 5015, + "Num Positive": 62, + "Positive %": 1.221, + "Num Positive per mm^2": 93.74 + } +} \ No newline at end of file diff --git a/119/TumorCenter_CD3_block10_x4_y11_patient119_1.json b/119/TumorCenter_CD3_block10_x4_y11_patient119_1.json new file mode 100644 index 0000000000000000000000000000000000000000..baf1f37925bd8383614dd2e40dea76fd6eaa9aa1 --- /dev/null +++ b/119/TumorCenter_CD3_block10_x4_y11_patient119_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16741.1, + "Centroid Y µm": 26810.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/119/TumorCenter_CD8_block10_x3_y11_patient119_0.json b/119/TumorCenter_CD8_block10_x3_y11_patient119_0.json new file mode 100644 index 0000000000000000000000000000000000000000..21fcd7cf7f5c02ec7e59e103b52dc01bb33fefd0 --- /dev/null +++ b/119/TumorCenter_CD8_block10_x3_y11_patient119_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11743.8, + "Centroid Y µm": 27985.2, + "Num Detections": 15547, + "Num Negative": 15346, + "Num Positive": 201, + "Positive %": 1.293, + "Num Positive per mm^2": 110.37 + } +} \ No newline at end of file diff --git a/119/TumorCenter_CD8_block10_x4_y11_patient119_1.json b/119/TumorCenter_CD8_block10_x4_y11_patient119_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a4a145180527a0a6a9c9c4d1d75def50e23fd074 --- /dev/null +++ b/119/TumorCenter_CD8_block10_x4_y11_patient119_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14292.4, + "Centroid Y µm": 27860.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/119/history_text.txt b/119/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..86b8448820f18d23f24ce50053692b2a269807bb --- /dev/null +++ b/119/history_text.txt @@ -0,0 +1 @@ +The patient had been experiencing pain on tongue movement in the area of the right tonsil for months, no dysphagia, no dyspnea, no weight loss. The preoperative sonography revealed a cT2 cN0 oropharyngeal tumor on the right. \ No newline at end of file diff --git a/119/icd_codes.txt b/119/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa5d6640b9c3cf48003ba5bae8cfcb9c089a438f --- /dev/null +++ b/119/icd_codes.txt @@ -0,0 +1 @@ +Unsichere Neubildung der Übergangsregion des Oropharynx[D37.0 ] \ No newline at end of file diff --git a/119/ops_codes.txt b/119/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..38c9367327e0ab371e28bdad0b3025d8e2b7a85c --- /dev/null +++ b/119/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Transorale partielle Tonsillektomie[5-281.5 ] Sonstige Tonsillektomie [ohne Adenotomie][5-281.x ] \ No newline at end of file diff --git a/119/patient_clinical_data.json b/119/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7cfa76efe9e6b2a376960976445d212a5ddbb608 --- /dev/null +++ b/119/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 57, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/119/patient_pathological_data.json b/119/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7f7858d0efbaef41a6a6d274c8f0acc8237e561f --- /dev/null +++ b/119/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "119", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/119/surgery_description.txt b/119/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6fb33d9fdfb40310cee8673f2057337bf2740d12 --- /dev/null +++ b/119/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Excisional biopsy in the context of tonsillectomy diff --git a/119/surgery_report.txt b/119/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..99257bc22d4fd06456b4a680d851120afe6ad382 --- /dev/null +++ b/119/surgery_report.txt @@ -0,0 +1 @@ +First deepening of the anesthesia. Insertion of the laryngoscope blade. Inspection of the trachea with the O° scope and the endolarynx. No abnormal findings here, the trachea appears clear up to the bifurcation. Problem-free orotracheal intubation by the surgeon. Inspection of the endolarynx with the Kleinsasser tube. Here, the pocket folds on both sides are unremarkable, as are the arytenoids on both sides. Postcricoid region without irritation, inconspicuous mucosa. The piriform sinus can be freely unfolded on both sides, no evidence of tumor growth, smooth mucosa. The vocal folds show smooth, inconspicuous mucosa on both sides. Now inspection of the epiglottis and the vallecula, here also unremarkable findings. The base of the tongue is unremarkable on inspection and palpation. Inspection of the oral cavity. Inconspicuous vestibulum oris, tongue also inconspicuous on inspection and palpation. Left glossotonsillar groove unremarkable. Soft palpation of the floor of the mouth. Now inspection of the oropharynx. Left tonsil region unremarkable, posterior pharyngeal wall smooth. Inspection of the right anterior palatal arch reveals an approx. 1.5 cm large, whitish deposit, coarse, palpable. The glossotonsillar groove does not appear to be involved in the process on palpation. Tonsil slightly coarse on the right, but not primarily tumor-suspect. Inspection of the nasopharynx using 70° optics, showing inconspicuous mucosal conditions. All findings are reproduced and confirmed by . Performing the esophagogastroscopy: Easy insertion of the flexible endoscope into the esophagus and visualization of the esophagus into the stomach, where a regular folded relief can be seen. After distension of the stomach, more detailed inspection of the mucosa. This appears atrophic overall. No evidence of ulcer or tumor growth. After aspiration of the insufflated air, careful reflection and examination of the esophageal mucosa. A slightly hypertrophic mucosa was found in the area of the esophagogastric junction, otherwise the mucosal conditions in the rest of the esophagus were unremarkable. Decision by to perform an excisional biopsy of the suspected tumor lesion as a right-sided tonsillectomy. Tumor resection through . Insertion of the oral spatula. The tumor in the area of the anterior palatal arch on the right is carefully excised with a safety margin of 0.5 cm. The anterior palatal arch falls, resection up to the alveolar ridge, the periosteum remains covered by soft tissue. In addition, a small part of the base of the tongue is removed. The posterior palatal arch remains completely intact. The excision also includes careful removal of the tonsil. Bipolar coagulation of the lower tonsil pole and finally separation of the complete preparation. This is sent to histology marked with a thread. Macroscopically, the tumor appears to be removed from the healthy tissue. An additional lateral margin sample is taken in the area of the alveolar ridge. Hemostasis with H202 swab and bipolar coagulation. Recheck of the surgical site, no source of bleeding visible. Conclusion: cT1 cN0 oropharyngeal carcinoma on the right. The specimen was thread-marked and sent for histologic processing. Macroscopically, the tumor appeared to be removed in healthy tissue; if the histological situation is also R0, neck dissection can be omitted according to . Wait for the histolog. Findings and presentation at our interdisciplinary tumor conference. \ No newline at end of file diff --git a/120/InvasionFront_CD3_block1_x1_y2_patient120_0.json b/120/InvasionFront_CD3_block1_x1_y2_patient120_0.json new file mode 100644 index 0000000000000000000000000000000000000000..caea6bf9b342a60b7e897e6283c18d6b6f27cbc0 --- /dev/null +++ b/120/InvasionFront_CD3_block1_x1_y2_patient120_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4497.6, + "Centroid Y µm": 6746.4, + "Num Detections": 19383, + "Num Negative": 17443, + "Num Positive": 1940, + "Positive %": 10.01, + "Num Positive per mm^2": 828.74 + } +} \ No newline at end of file diff --git a/120/InvasionFront_CD3_block1_x2_y2_patient120_1.json b/120/InvasionFront_CD3_block1_x2_y2_patient120_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9624e414f2f2439a7c72d745a72aca78b592bd41 --- /dev/null +++ b/120/InvasionFront_CD3_block1_x2_y2_patient120_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 6721.4, + "Num Detections": 18397, + "Num Negative": 15923, + "Num Positive": 2474, + "Positive %": 13.45, + "Num Positive per mm^2": 1052.1 + } +} \ No newline at end of file diff --git a/120/InvasionFront_CD8_block1_x1_y2_patient120_0.json b/120/InvasionFront_CD8_block1_x1_y2_patient120_0.json new file mode 100644 index 0000000000000000000000000000000000000000..360db7db5ef5de18c243cabc16bae31dc3d5fd36 --- /dev/null +++ b/120/InvasionFront_CD8_block1_x1_y2_patient120_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4672.5, + "Centroid Y µm": 4972.4, + "Num Detections": 19420, + "Num Negative": 14467, + "Num Positive": 4953, + "Positive %": 25.5, + "Num Positive per mm^2": 2109.2 + } +} \ No newline at end of file diff --git a/120/InvasionFront_CD8_block1_x2_y2_patient120_1.json b/120/InvasionFront_CD8_block1_x2_y2_patient120_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6130d4f15b2a55ed2ac2a38e38fd12307c129451 --- /dev/null +++ b/120/InvasionFront_CD8_block1_x2_y2_patient120_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7221.2, + "Centroid Y µm": 5122.3, + "Num Detections": 18670, + "Num Negative": 14223, + "Num Positive": 4447, + "Positive %": 23.82, + "Num Positive per mm^2": 1888.8 + } +} \ No newline at end of file diff --git a/120/TumorCenter_CD3_block1_x1_y4_patient120_0.json b/120/TumorCenter_CD3_block1_x1_y4_patient120_0.json new file mode 100644 index 0000000000000000000000000000000000000000..86f02b8b65b96fb2b70cb382e2f040d39b45885b --- /dev/null +++ b/120/TumorCenter_CD3_block1_x1_y4_patient120_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3417.2, + "Centroid Y µm": 10615.0, + "Num Detections": 14007, + "Num Negative": 12734, + "Num Positive": 1273, + "Positive %": 9.088, + "Num Positive per mm^2": 700.78 + } +} \ No newline at end of file diff --git a/120/TumorCenter_CD3_block1_x2_y4_patient120_1.json b/120/TumorCenter_CD3_block1_x2_y4_patient120_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e6cafecea289a5138590c43ddae329a1ef3b0dde --- /dev/null +++ b/120/TumorCenter_CD3_block1_x2_y4_patient120_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 10494.4, + "Num Detections": 10830, + "Num Negative": 9097, + "Num Positive": 1733, + "Positive %": 16.0, + "Num Positive per mm^2": 1147.4 + } +} \ No newline at end of file diff --git a/120/TumorCenter_CD8_block1_x1_y2_patient120_0.json b/120/TumorCenter_CD8_block1_x1_y2_patient120_0.json new file mode 100644 index 0000000000000000000000000000000000000000..003bdd8c6db809d3bf572fee3dcb0baaec51b19d --- /dev/null +++ b/120/TumorCenter_CD8_block1_x1_y2_patient120_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 14092.5, + "Num Detections": 16672, + "Num Negative": 15493, + "Num Positive": 1179, + "Positive %": 7.072, + "Num Positive per mm^2": 546.13 + } +} \ No newline at end of file diff --git a/120/TumorCenter_CD8_block1_x2_y2_patient120_1.json b/120/TumorCenter_CD8_block1_x2_y2_patient120_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b31d10cbc19d23eba2642629e0bc7ed8e6dc7920 --- /dev/null +++ b/120/TumorCenter_CD8_block1_x2_y2_patient120_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8845.3, + "Centroid Y µm": 13967.6, + "Num Detections": 18167, + "Num Negative": 16862, + "Num Positive": 1305, + "Positive %": 7.183, + "Num Positive per mm^2": 586.4 + } +} \ No newline at end of file diff --git a/120/history_text.txt b/120/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/120/icd_codes.txt b/120/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adab28f0b88ba31c5bb4895a3d4f3034f2967b3e --- /dev/null +++ b/120/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] \ No newline at end of file diff --git a/120/ops_codes.txt b/120/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d807b146f106cb41b09560fccb06c33e8b3903c1 --- /dev/null +++ b/120/ops_codes.txt @@ -0,0 +1 @@ +Exzision Tonsillentumor[5-289.x ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie mit Rekonstruktion Sonstige[5-295.1x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Hemiglossektomie durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Spalthaut auf granulierendes Hautareal großflächig Empfängerstelle Oberschenkel und Knie[5-902.5e R] \ No newline at end of file diff --git a/120/patient_clinical_data.json b/120/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..357ba768d057578abbf136a24eca0d6ec37a854f --- /dev/null +++ b/120/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 76, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/120/patient_pathological_data.json b/120/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6d5bf1176e0a2c752f470d37de553cc214f493e4 --- /dev/null +++ b/120/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "120", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/120/surgery_description.txt b/120/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6f8e437f6632b4d83ecf3a681a5f99bdffeb959f --- /dev/null +++ b/120/surgery_description.txt @@ -0,0 +1 @@ +Transcervical resection, Selective bilateral neck dissection, Free flap (Radial), Tracheotomy, PEG, Radiotherapy planned in the ER (Emergency Room) diff --git a/120/surgery_report.txt b/120/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..03635d692866e87cc0ca73209f53189de9659bb7 --- /dev/null +++ b/120/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesiologist. After appropriate preparation, oropharyngoscopy is performed once again: the ulcerated tumor can be seen here, which appears to be limited to the tonsil but extends laterally on palpation. Insertion of the PEG tube After entering the stomach and postoperative diaphanoscopy, the tube is inserted under visualization. This is done without any problems. Application of a wound dressing. Infiltration with local anesthetic in the neck area. Performing the tracheostomy: To do this, sharply cut through the skin and subcutaneous fatty tissue. Push apart the prelaryngeal muscles, undermine the isthmus of the thyroid gland and expose the pretracheal lamina. Then opening of the trachea between the 2nd and 3rd tracheal clasp and easy reintubation of the patient. Placement of the lower stoma sutures for mucocutaneous anastomosis. Then sterile washing and draping of the neck, arm and right thigh. Start with the neck dissection on the right side. Here, while protecting all non-lymphatic structures, regions I to V are evacuated after exposure and skeletonization of the sternocleidomastoid muscle. Neurolysis of the accessorius and hypoglossal nerves and re-embedding of the nerves. The superior thyroid, lingual and facial arteries are then exposed at their exit from the external carotid artery, thus shifting the external carotid artery laterally until the tumor can be safely bypassed. The lingual artery on the right side cannot be preserved as it runs through the middle of the tumor, so it is removed. The hypoglossal nerve is completely skeletonized and can be preserved until the end. On palpation, the tumor extends to just above the hyoid bone. The pharynx is then opened caudal to the tumor and cranial to the hyoid bone in the area of the lateral hypopharyngeal wall. The tumor is then successively developed completely from the transcervical side under visual control and resected with an appropriate safety margin. Histology is then taken from the mucosal margins. These are all found to be tumor-free on frozen section histology. Subsequent measurement of the defect with a 7 x 5.5 cm defect. Transition to neck dissection of the left side. This is performed in the same way as on the right side after visualization and skeletonization of the sternocleidomastoid muscle, including displacement, neurolysis and re-embedding of the accessory nerve and hypoglossus. Here too, all non-lymphatic structures are spared and regions II to V are removed. Closure of the left side of the neck using multi-layered sutures after insertion of a Redon suction drain. Application of a pressure dressing. Elevation of the radial forearm flap on the left Palpatory identification of the distal radial artery. Marking of the flap boundaries (7 x 5.5 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the pronator quadratus and flexor pollicis longus muscles with ligation of the outgoing perforators using a vascular clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Covering of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. After appropriate development of the radial lobe graft, it is inserted transcervically into the defect. The radialis flap is then sutured transorally into the right oropharynx. The last caudal sutures in the area of the base of the tongue and the lateral hypopharyngeal wall are performed transcervically, resulting in complete tension-free closure of the defect. Check again transorally. The two anastomoses are then performed. First, the arterial anastomosis is performed after appropriate preliminary preparation of the superior thyroid artery. The large caliber vein, which accommodates the superficial as well as the deep drainage area of the flap, is attached to the internal jugular vein in an end-to-side anastomosis. No bleeding visible on final check with vital graft. Insertion of a Redon suction drain as well as an Easy-Flow drain. Multi-layer wound closure on the right cervical side. Application of a pressure dressing. Control of the flap transorally, whereby the graft is absolutely vital. Re-intubation of the patient onto an 8-gauge Rügheimer cannula, which is fixed to the skin. Application of a neck bandage. Final consultation with the anesthetist. Conclusion: Transcervical resection of a tonsillar carcinoma on the right side with selective neck dissection on both sides. Defect coverage via a microvascularly anastomosed radial artery flap graft from the left forearm. The arterial anastomosis is made via the superior thyroid artery. The venous anastomosis forms an end-to-side anastomosis to the internal jugular vein. Defect coverage on the left forearm via a split-thickness skin graft from the right thigh. Additional tracheotomy and PEG placement. \ No newline at end of file diff --git a/121/InvasionFront_CD3_block1_x1_y8_patient121_0.json b/121/InvasionFront_CD3_block1_x1_y8_patient121_0.json new file mode 100644 index 0000000000000000000000000000000000000000..183ffc99b8321539d60fef122d82aa6b4062cd36 --- /dev/null +++ b/121/InvasionFront_CD3_block1_x1_y8_patient121_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3687.5, + "Centroid Y µm": 21468.2, + "Num Detections": 18140, + "Num Negative": 17763, + "Num Positive": 377, + "Positive %": 2.078, + "Num Positive per mm^2": 165.15 + } +} \ No newline at end of file diff --git a/121/InvasionFront_CD3_block1_x2_y8_patient121_1.json b/121/InvasionFront_CD3_block1_x2_y8_patient121_1.json new file mode 100644 index 0000000000000000000000000000000000000000..732f867ed915cd2b97fc4f384053348af5aa9c21 --- /dev/null +++ b/121/InvasionFront_CD3_block1_x2_y8_patient121_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6358.2, + "Centroid Y µm": 21651.4, + "Num Detections": 10565, + "Num Negative": 9927, + "Num Positive": 638, + "Positive %": 6.039, + "Num Positive per mm^2": 459.17 + } +} \ No newline at end of file diff --git a/121/InvasionFront_CD8_block1_x1_y8_patient121_0.json b/121/InvasionFront_CD8_block1_x1_y8_patient121_0.json new file mode 100644 index 0000000000000000000000000000000000000000..797a2322f8d3e29f35543fda352e10fe57afd0f7 --- /dev/null +++ b/121/InvasionFront_CD8_block1_x1_y8_patient121_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3806.2, + "Centroid Y µm": 20079.0, + "Num Detections": 18446, + "Num Negative": 18401, + "Num Positive": 45, + "Positive %": 0.244, + "Num Positive per mm^2": 19.35 + } +} \ No newline at end of file diff --git a/121/InvasionFront_CD8_block1_x2_y8_patient121_1.json b/121/InvasionFront_CD8_block1_x2_y8_patient121_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7b687a52e34db04d2bc89c9d490ffc2de6d1b31d --- /dev/null +++ b/121/InvasionFront_CD8_block1_x2_y8_patient121_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6509.1, + "Centroid Y µm": 20126.8, + "Num Detections": 16105, + "Num Negative": 15847, + "Num Positive": 258, + "Positive %": 1.602, + "Num Positive per mm^2": 132.27 + } +} \ No newline at end of file diff --git a/121/TumorCenter_CD3_block1_x1_y10_patient121_0.json b/121/TumorCenter_CD3_block1_x1_y10_patient121_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c53eb53326af855b42907bc2ff286845cb4e99c2 --- /dev/null +++ b/121/TumorCenter_CD3_block1_x1_y10_patient121_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 25261.6, + "Num Detections": 26959, + "Num Negative": 25355, + "Num Positive": 1604, + "Positive %": 5.95, + "Num Positive per mm^2": 642.26 + } +} \ No newline at end of file diff --git a/121/TumorCenter_CD3_block1_x2_y10_patient121_1.json b/121/TumorCenter_CD3_block1_x2_y10_patient121_1.json new file mode 100644 index 0000000000000000000000000000000000000000..79d85c3459639d95a2a590df45ffdb7cbbcf6c6a --- /dev/null +++ b/121/TumorCenter_CD3_block1_x2_y10_patient121_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 25061.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/121/TumorCenter_CD8_block1_x1_y8_patient121_0.json b/121/TumorCenter_CD8_block1_x1_y8_patient121_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c97487264b9265cb60207e6f6174c02881453091 --- /dev/null +++ b/121/TumorCenter_CD8_block1_x1_y8_patient121_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 28784.8, + "Num Detections": 16180, + "Num Negative": 16145, + "Num Positive": 35, + "Positive %": 0.2163, + "Num Positive per mm^2": 16.25 + } +} \ No newline at end of file diff --git a/121/TumorCenter_CD8_block1_x2_y8_patient121_1.json b/121/TumorCenter_CD8_block1_x2_y8_patient121_1.json new file mode 100644 index 0000000000000000000000000000000000000000..745594f8b2cfeea3ab737ac57c8025e97c738198 --- /dev/null +++ b/121/TumorCenter_CD8_block1_x2_y8_patient121_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8970.3, + "Centroid Y µm": 28759.8, + "Num Detections": 20372, + "Num Negative": 19391, + "Num Positive": 981, + "Positive %": 4.815, + "Num Positive per mm^2": 421.26 + } +} \ No newline at end of file diff --git a/121/history_text.txt b/121/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b13cd952f5b4f0fccf1760d54ae15878487e4b0 --- /dev/null +++ b/121/history_text.txt @@ -0,0 +1 @@ +In the patient, a moderately differentiated squamous cell carcinoma in the right oropharynx was histologically confirmed during a panendoscopy <2012>. Intraoperative cT2 cN2b oropharyngeal carcinoma on the right. The immediate preoperative ultrasound showed a cN1 neck status. \ No newline at end of file diff --git a/121/icd_codes.txt b/121/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/121/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/121/ops_codes.txt b/121/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bcdd6bb22672c7a37eb5aae2083c70ddb67c9e4e --- /dev/null +++ b/121/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Temporäre Tracheotomie[5-311.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Ausräumung und Drainage postoperatives Hämatom subkutan Hals[5-892.15 ] Operative Blutstillung nach Gefäß-OP[5-394.0 ] \ No newline at end of file diff --git a/121/patient_clinical_data.json b/121/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3ed47701c9f173edc28476001de454e12228c34f --- /dev/null +++ b/121/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/121/patient_pathological_data.json b/121/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ae080e56168d9fdfec2c128130343a357b980f38 --- /dev/null +++ b/121/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "121", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/121/surgery_description.txt b/121/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1cc0e6339936ad560b0e1195d0de8a2eaf35b722 --- /dev/null +++ b/121/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Neck dissection, PEG placement, Free flap coverage (Radial), Tracheotomy diff --git a/121/surgery_report.txt b/121/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..65d2aff5aa1205a39e0775c4d3347068a36822e5 --- /dev/null +++ b/121/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesia colleagues, the patient is positioned. First, the tumor is inspected enorally. An exophytic tumor is seen in the area of the right tonsil with macroscopically clearly carcinomatous extensions towards the soft palate to the right parauvular region. Partly island-like tumor growth. The tumor extends towards the buccal and alveolar ridge, does not reach the maxilla. No deep infiltration of the soft tissues of the cheek, superficial growth also in the area of the alveolar ridge. The dorsal floor of the mouth is infiltrated via the glossotonsillar groove and the posterior floor of the mouth, also submucosal tumor growth towards the edge of the tongue. The right edge of the tongue is infiltrated over approximately half the length, approximately Ľ deep infiltration. Tumor growth to just before the posterior palatal arch. The posterior pharyngeal wall is free, as is the caudal pharyngeal side wall towards the entrance to the piriform sinus. Overall, the extent is clearly cT3. PEG insertion is performed first. This is done with the gastroscope. Careful endoscopy into the stomach. With excellent diaphanoscopy, problem-free puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. The patient is then prepared for definitive tumor resection. Injection of xylocaine with added adrenaline. First start with transoral resection. The tumor is completely marked and cut around with a safety margin of approx. 1 cm in the area of the oral cavity and 1.5 cm in the area of the tongue. All suspicious mucosal changes localized in the marginal area are removed. This results in a subtotal resection of the soft palate. Removal towards the upper jaw and soft cheek parts. Exposure of the pterygoid muscles. Clearly safe and free tissue conditions in depth. Incision of the alveolar mucosa. This is done sharply down to the bone. Detachment of the mucosa with removal of the periosteum. Resection of the posterior floor of the mouth. Resection of the right edge of the tongue. Resection up to the base of the tongue. Total approx. Ľ resection of the tongue. Part of the submandibular gland is removed transorally in the area of the posterior floor of the mouth to maintain a safety margin. The lingual nerve must also be resected during tumor resection. With macroscopic in sano resection of the tumor, marginal specimens are taken from the specimen that completely depict the primary tumor. These are completely resected as tumor-free in the frozen section diagnosis, therefore an overall R0 situation can be assumed here. The graft is now measured. The neck dissections are then carried out. The neck dissection of the right side and the tracheotomy were performed in parallel with the graft elevation from the left forearm. The neck dissection of the left side is performed first. To do this, make a curved skin incision on the front edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Creation of a platysma flap. Exposure and preservation of the external jugular vein. Exposure of the sternocleidomastoid, omohyoid and digastric muscles. Exposure of the submandibular gland. Free dissection of the internal jugular vein with exposure and preservation of the facial vein. Dissection of the anterior neck preparation with careful preservation of the superior thyroid artery, the cervical artery and the hypoglossal nerve. Exposure of the accessorius nerve. Clearing of the accessorius triangle with careful protection of the nerves. Subsequent release of level V with careful protection of the cervical plexus branches. No caudal evidence of lymphatic leakage. Clinically no highly suspicious masses on the left side. After careful wound inspection, after wound irrigation, with dry wound conditions and insertion of a 10 Redon drainage, careful, two-layer wound closure. Subsequent repositioning for neck dissection on the opposite side. The procedure is basically the same here. Skin incision on the front edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Creation of a platysma flap. Exposure of the sternocleidomastoid, omohyoid and digastric muscles. Clearing out the anterior neck preparation while carefully protecting the superior thyroid artery and the hypoglossal nerve. A facial vein is not developed here. Exposure and preservation of the external jugular vein. Complete dissection of the internal jugular vein. Clearing of the accessorius triangle with careful protection of the nerve. Evacuation of level V while protecting the cervical plexus branches. Level II revealed a lymph node measuring approx. 2 x 2 cm, round and therefore suspicious, otherwise subcapsular release of the submandibular gland. Resection of the remaining gland after, as described above, resection already by transoral resection. Careful release of level I b, here several lymph nodes measuring up to 1 ˝ cm. Now resection of the digastric muscle. Overall, a relatively wide shaft is now created enorally, approx. 3 transverse fingers wide. Careful wound irrigation and wound inspection. First turn to the plastic tracheotomy. To do this, make a skin incision at the level of the cricoid cartilage. Cut through the skin and subcutaneous tissue. Cut through the infrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Dissection of the thyroid isthmus. Insertion between the 1st and 2nd tracheal ring. First creation of a broad-based pedicled Björk flap, this is relatively vulnerable, therefore a tracheal window is created. The trachea is then sutured in the usual manner using the back-stitch technique. Subsequently, intubation is first changed to a Woodbridge tube and later to a size 8 low cuff cannula. The radialis graft is then lifted from the left forearm. After the graft has already been measured enorally with a special soft palate and tongue edge configuration, a graft measuring up to 10 x 10 cm is marked. Positioning over the radial artery while protecting the retinaculum. Application of the tourniquet. Radial incision of the graft, taking the cephalic vein with it. Exposure of the brachioradialis muscle. Exposure of the superficial radial nerve ramus and preservation of the complete nerve in its course. Ulnar visualization of the flexor carpi ulnaris muscle. Identification of the distal vascular pedicle. Removal of the vascular pedicle after ligation. Strictly subfascial release with clipping of distal pedicle branches. Proximal dissection. Exposure of the ulnar artery. Exposure of the radial vein and artery. Exposure of the common interosseous artery. It is now apparent that the cephalic vein does not have a pronounced connection to the deep venous system, therefore several strong accompanying veins are elevated in relation to the graft. A total of 4 graft veins were elevated. After reopening the tourniquet, regular hand perfusion and excellent graft perfusion. Careful hemostasis of the graft and forearm. Subsequent removal of the vital graft after ligation of the feeding and draining vessels. The graft is then carefully implanted transorally. Overall good fit and intact conditions on all sides. Overall, somewhat laborious insertion conditions due to the size of the defect. In conclusion, however, a good result. Transcervical pedicle positioning. Conditioning of the superior thyroid artery. There is also a superior thyroid vein and the strong external jugular vein. After conditioning the flap vessels, perform the arterial anastomosis with Ethilon 8-0. Subsequently, create tight relationships. Select 2 strong, returning venous vessels. Anastomosis of a vein to the stump of the superior thyroid vein. Also anastomosis to the external jugular vein. Subsequent regular graft perfusion. Regular flow from the vessels with a positive smear test, so that a 10 Redon drain is inserted on the right cervical side if the graft perfusion is regular. Subsequent careful, two-layer wound closure. Now to the treatment of the left forearm. First, careful, two-layer wound closure after final wound inspection. Then insertion of the full-thickness skin graft harvested from the right groin. Careful trimming of the full-thickness skin. Final good fit. Subsequent application of a hydrogel and Mepilex dressing and application of the stretcher splint functional position. Now for full-thickness skin harvesting from the right groin. Trimming of a piece of full-thickness skin measuring approx. 14 x 10 cm. Strict cutaneous lifting. Final thinning of the graft. Subsequent extensive subcutaneous mobilization down to the abdominal fascia and the fascia lata. Careful hemostasis. Insertion of a 10-gauge Redon drain and careful, two-layer wound closure under very low tension conditions. Final inspection and completion of the procedure with a vital graft, without any indication of complications. The patient received intraoperative intravenous antibiotics with Unacid 3 g. Conclusion: Intraoperative R0-resected cT3 cN1 G2 oropharyngeal carcinoma on the right. Defect reconstruction using a microvascular anastomosed radialis graft. Postoperatively, please carry out an X-ray gruel swallow on the 8th to 9th postoperative day, after which a diet can be set up depending on swallowing function. \ No newline at end of file diff --git a/122/InvasionFront_CD3_block21_x1_y8_patient122_0.json b/122/InvasionFront_CD3_block21_x1_y8_patient122_0.json new file mode 100644 index 0000000000000000000000000000000000000000..90c21dd4763b89a39a2cb0d794282d16a3b10806 --- /dev/null +++ b/122/InvasionFront_CD3_block21_x1_y8_patient122_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5697.0, + "Centroid Y µm": 30059.1, + "Num Detections": 19303, + "Num Negative": 17274, + "Num Positive": 2029, + "Positive %": 10.51, + "Num Positive per mm^2": 864.16 + } +} \ No newline at end of file diff --git a/122/InvasionFront_CD3_block21_x2_y8_patient122_1.json b/122/InvasionFront_CD3_block21_x2_y8_patient122_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1bd878e82c66b5868bf02eee28665fa06c7ef5c5 --- /dev/null +++ b/122/InvasionFront_CD3_block21_x2_y8_patient122_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8270.6, + "Centroid Y µm": 30309.0, + "Num Detections": 13852, + "Num Negative": 12840, + "Num Positive": 1012, + "Positive %": 7.306, + "Num Positive per mm^2": 557.53 + } +} \ No newline at end of file diff --git a/122/InvasionFront_CD8_block21_x1_y8_patient122_0.json b/122/InvasionFront_CD8_block21_x1_y8_patient122_0.json new file mode 100644 index 0000000000000000000000000000000000000000..20673883051c2cd642e41ee417747c3fda2a3d6c --- /dev/null +++ b/122/InvasionFront_CD8_block21_x1_y8_patient122_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3373.2, + "Centroid Y µm": 19664.6, + "Num Detections": 19600, + "Num Negative": 18750, + "Num Positive": 850, + "Positive %": 4.337, + "Num Positive per mm^2": 348.19 + } +} \ No newline at end of file diff --git a/122/InvasionFront_CD8_block21_x2_y8_patient122_1.json b/122/InvasionFront_CD8_block21_x2_y8_patient122_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b01f4e326e4e405262876b8a7de78ffcae4f32fe --- /dev/null +++ b/122/InvasionFront_CD8_block21_x2_y8_patient122_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 19689.6, + "Num Detections": 16300, + "Num Negative": 15897, + "Num Positive": 403, + "Positive %": 2.472, + "Num Positive per mm^2": 184.37 + } +} \ No newline at end of file diff --git a/122/TumorCenter_CD3_block21_x1_y8_patient122_0.json b/122/TumorCenter_CD3_block21_x1_y8_patient122_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e25d250598fd9dc1b4371711e036a613eddcfcda --- /dev/null +++ b/122/TumorCenter_CD3_block21_x1_y8_patient122_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3697.2, + "Centroid Y µm": 22854.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/122/TumorCenter_CD3_block21_x2_y8_patient122_1.json b/122/TumorCenter_CD3_block21_x2_y8_patient122_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e5a9ecb08c4335f864131c5386199bf961f15929 --- /dev/null +++ b/122/TumorCenter_CD3_block21_x2_y8_patient122_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6308.4, + "Centroid Y µm": 22658.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/122/TumorCenter_CD8_block21_x1_y8_patient122_0.json b/122/TumorCenter_CD8_block21_x1_y8_patient122_0.json new file mode 100644 index 0000000000000000000000000000000000000000..28dc3ea8f1e282afaa910e9c7c058e8984f2dbb0 --- /dev/null +++ b/122/TumorCenter_CD8_block21_x1_y8_patient122_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5747.0, + "Centroid Y µm": 34606.7, + "Num Detections": 3104, + "Num Negative": 2714, + "Num Positive": 390, + "Positive %": 12.56, + "Num Positive per mm^2": 861.57 + } +} \ No newline at end of file diff --git a/122/TumorCenter_CD8_block21_x2_y8_patient122_1.json b/122/TumorCenter_CD8_block21_x2_y8_patient122_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c1af8bbdb287e63894365a18546feff9e18d4548 --- /dev/null +++ b/122/TumorCenter_CD8_block21_x2_y8_patient122_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8395.6, + "Centroid Y µm": 34706.6, + "Num Detections": 8592, + "Num Negative": 8266, + "Num Positive": 326, + "Positive %": 3.794, + "Num Positive per mm^2": 353.27 + } +} \ No newline at end of file diff --git a/122/history_text.txt b/122/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..766b972169a33a17490f5b157523b9d3c33dc0d8 --- /dev/null +++ b/122/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma. Extension transglottic on the right. In the area of the anterior commissure, extending to the left side up to at least 1/3 of the left vocal fold macroscopically. No evidence of thyroid cartilage infiltration on CT. Therefore indication for the above mentioned operation. \ No newline at end of file diff --git a/122/icd_codes.txt b/122/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/122/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/122/ops_codes.txt b/122/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0cd9918f2faa974b768ad24f4b58406a9de9a0a5 --- /dev/null +++ b/122/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Diagnostische ÖGD[1-632 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/122/patient_clinical_data.json b/122/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b513d234b0b2401e8455e67bf2c2af2d3abc0cd9 --- /dev/null +++ b/122/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/122/patient_pathological_data.json b/122/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e36e416a92206a02812d51902adb6671e79b88a3 --- /dev/null +++ b/122/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "122", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/122/surgery_description.txt b/122/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c5004c5a25fd658e964e64b6ec3df515d37624aa --- /dev/null +++ b/122/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection (Leroux-Robert), Neck dissection diff --git a/122/surgery_report.txt b/122/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cb4d2e008b340b9b08c321be20d0eae390ce8be6 --- /dev/null +++ b/122/surgery_report.txt @@ -0,0 +1 @@ +First of all, MLE again: The tumor described appears, which extends slightly from supraglottic to nasoglottic, over the anterior commissure to the left and down to just under half of the left vocal fold. Therefore indication for the above mentioned surgery. First attempt at PEG insertion: Pre-mirroring of the esophagoscope into the stomach. Even after several attempts, diaphanoscopy could not be achieved, so that the PEG placement seemed too risky. A feeding tube is therefore inserted. Tracheostoma placement: The thyroid isthmus is exposed via the caudal end of the zigzag incision. This is clamped off and supplied using puncture ligatures. Enter the inter-cartilaginous space between the 2nd and 3rd tracheal cartilage. Creation of a wide-stemmed Björk flap. Now repositioning for tracheostomy and fronto-lateral partial laryngeal resection: injection of a total of 20 ml xylocaine 1% with adrenaline into both sides of the neck and prelaryngeally. Prelaryngeal zigzag incision leading into the tracheostomy. Expose the infrahyoid muscles. Push off the soft tissue. Splitting of the infrahyoid musculature. Section paramedian left through the perichondrium to the thyroid cartilage. Dissection of the soft tissue from the laryngeal skeleton on both sides down to the cricoid cartilage. Thyrofissure with the wheel saw, sawing out a triangle that begins just below the incision. This is followed by dissection of the perichondrium from the remaining thyroid cartilage on both sides. No tumor infiltrates as already described in the CT are visible here either. Entering the larynx cranially. Overview of the tumor. Overview also relatively difficult via direct view, so that the tumor is finally transected medially. The tumor can now also be seen with a good overview of its subglottic extension. The tumor is initially removed on the left with a safety margin of several mm on all sides, whereby the resection is also carried out slightly subglottically. Resection also includes 2/3 of the left vocal fold including the ventriculus laryngeus and parts of the pocket fold. On the right, the tumor was also macroscopically resected with a safety margin of several mm on all sides. Here, a clear part of the subglottic area was resected. The resection extends to the arytenoid cartilage, which is partially resected. The cranial pocket fold is also resected. Caudally, the upper edge of the cricoid cartilage is exposed. Both specimens are marked with sutures and sent for frozen section. Margin samples from the arytenoid region, from the interary region to the left and from the lateral and cranial sides are also sent in. Preparation on the left completely healthy. On the right, subglottic to cranial and in the arytenoid region not in healthy tissue. Also marginal specimen in the interary region with CIS and marginal specimen cranial with CIS, also marginal specimen in the arytenoid region with CIS. Therefore, a 5-6 mm wide strip is resected again subglottically, covering the entire mucosa from the left paramedian to the posterior wall. This is thread-marked to the frozen section. No more infiltrates in the frozen section. A resection is also taken from the cranial area with a subsequent marginal sample. No more infiltrates in the frozen section. A resection is taken from the interary area as well as a further marginal sample, which extends to the left arytenoid cartilage. Here, mild to moderate dysplasia, but no CIS. Another extensive marginal sample is sent in from the ary area, which again includes parts of the arytenoid cartilage and surrounding soft tissue. Still carcinoma in situ infiltrates here. Another marginal sample is therefore sent in. This includes all cartilage and soft tissue parts up to the upper edge of the cricoid cartilage up to the mucosa of the postcricoid region, which, however, remains intact. The remaining marginal sample is sent for final diagnosis. If this marginal sample is positive, a laryngectomy is probably unavoidable for oncological reasons. Mucosa from the postcricoid region is sutured to the cricoid cartilage with two 3.0 Vicryl sutures to improve epithelialization. Subsequently, remnants of the pocket ligament are fixed to the left side of the thyroid cartilage via a drill hole. The thyroid cartilage is readapted cranially via drill holes. Perichondrium with attached soft tissue is successively adapted with Vicryl 4.0 single button sutures until complete soft tissue closure over the cartilage is achieved. The infrahyoid musculature is then sutured over the perichondrium. The wound is closed in layers with epithelialization of the previously inserted tracheostoma. A 9 mm tracheostomy tube is then inserted. Neck dissection on both sides: Beginning with the right side: Curved incision in front of the sternocleidomastoid muscle. Exposure of the anterior border of the sternocleidomastoid muscle and dissection of the fat lymph node package. Exposure of V. jugularis interna, exposure of A. carotis communis, A. carotis interna, A. carotis externa and A. thyroidea superior. Visualization of vagus nerve, accessorius nerve, hypoglossal nerve. Successive development of the anterior neck preparation with visualization and preservation of the hypoglossal nerve and superior thyroid artery. Subsequent development of the dorsal neck preparation with preservation of the branches of the cervical plexus. In level 2, cranial lymph nodes clearly suspected of malignancy. Neck dissection is then performed on the left side: in principle, this is performed in the same way as on the right side. The structures mentioned are also visualized. Levels 2-4 are evacuated. Irrigation of the entire wound area on both sides and careful hemostasis. Wound closure in layers with insertion of a Redon drain in each case. Completion of the procedure without complications. Patient goes to intensive care unit for postoperative monitoring. Intraoperatively started antibiotic treatment with clindamycin should be continued for at least 1 week with 4 x 300 mg/die. Wait for final histology. If residual histology from the right arytenoid region is tumor-free, radiation therapy should be discussed postoperatively in the residual laryngeal region. In the case of extensive resection in the arytenoid region, dysfunction of the swallowing function and protracted swallowing rehabilitation are to be expected, so this should be initiated as early as possible. In addition, control MLE should be performed in approx. 3 months. If histology in the arytenoid region continues to show carcinoma, a residual laryngectomy cannot be avoided for oncological reasons. The patient should then undergo speech rehabilitation. \ No newline at end of file diff --git a/123/InvasionFront_CD3_block12_x3_y11_patient123_0.json b/123/InvasionFront_CD3_block12_x3_y11_patient123_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cae5607423248bc550edf08097754cc2a48d77ee --- /dev/null +++ b/123/InvasionFront_CD3_block12_x3_y11_patient123_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10444.5, + "Centroid Y µm": 32008.1, + "Num Detections": 18756, + "Num Negative": 16875, + "Num Positive": 1881, + "Positive %": 10.03, + "Num Positive per mm^2": 819.85 + } +} \ No newline at end of file diff --git a/123/InvasionFront_CD3_block12_x4_y11_patient123_1.json b/123/InvasionFront_CD3_block12_x4_y11_patient123_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f5dca4dfc36a041eaadad794e45af5ec770bc65c --- /dev/null +++ b/123/InvasionFront_CD3_block12_x4_y11_patient123_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13068.1, + "Centroid Y µm": 32307.9, + "Num Detections": 16381, + "Num Negative": 15041, + "Num Positive": 1340, + "Positive %": 8.18, + "Num Positive per mm^2": 624.66 + } +} \ No newline at end of file diff --git a/123/InvasionFront_CD8_block12_x3_y11_patient123_0.json b/123/InvasionFront_CD8_block12_x3_y11_patient123_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6affcde902a8ee573bf5948b68739f96fc4ff330 --- /dev/null +++ b/123/InvasionFront_CD8_block12_x3_y11_patient123_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12743.3, + "Centroid Y µm": 31308.4, + "Num Detections": 19044, + "Num Negative": 17558, + "Num Positive": 1486, + "Positive %": 7.803, + "Num Positive per mm^2": 623.33 + } +} \ No newline at end of file diff --git a/123/InvasionFront_CD8_block12_x4_y11_patient123_1.json b/123/InvasionFront_CD8_block12_x4_y11_patient123_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1bbbea46a77fae3631634ac3567ad7c0e5502740 --- /dev/null +++ b/123/InvasionFront_CD8_block12_x4_y11_patient123_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15441.8, + "Centroid Y µm": 31308.4, + "Num Detections": 17770, + "Num Negative": 16805, + "Num Positive": 965, + "Positive %": 5.431, + "Num Positive per mm^2": 443.97 + } +} \ No newline at end of file diff --git a/123/TumorCenter_CD3_block12_x3_y11_patient123_0.json b/123/TumorCenter_CD3_block12_x3_y11_patient123_0.json new file mode 100644 index 0000000000000000000000000000000000000000..127d84ed684a91ae1e1c05e0f9618e7f41656553 --- /dev/null +++ b/123/TumorCenter_CD3_block12_x3_y11_patient123_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10369.5, + "Centroid Y µm": 27260.6, + "Num Detections": 22856, + "Num Negative": 22002, + "Num Positive": 854, + "Positive %": 3.736, + "Num Positive per mm^2": 334.21 + } +} \ No newline at end of file diff --git a/123/TumorCenter_CD3_block12_x4_y11_patient123_1.json b/123/TumorCenter_CD3_block12_x4_y11_patient123_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a98c5983153b900a677a6fca5b56d600a2f965c2 --- /dev/null +++ b/123/TumorCenter_CD3_block12_x4_y11_patient123_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12868.2, + "Centroid Y µm": 27435.5, + "Num Detections": 21214, + "Num Negative": 17815, + "Num Positive": 3399, + "Positive %": 16.02, + "Num Positive per mm^2": 1393.8 + } +} \ No newline at end of file diff --git a/123/TumorCenter_CD8_block12_x3_y11_patient123_0.json b/123/TumorCenter_CD8_block12_x3_y11_patient123_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5709a0a24e612c5dbd0854fa0543b9d29bdd4c77 --- /dev/null +++ b/123/TumorCenter_CD8_block12_x3_y11_patient123_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13218.0, + "Centroid Y µm": 36505.7, + "Num Detections": 21326, + "Num Negative": 21064, + "Num Positive": 262, + "Positive %": 1.229, + "Num Positive per mm^2": 104.72 + } +} \ No newline at end of file diff --git a/123/TumorCenter_CD8_block12_x4_y11_patient123_1.json b/123/TumorCenter_CD8_block12_x4_y11_patient123_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ad8b6c19d2b9433b76dc0ce77c8ea9cf35a294db --- /dev/null +++ b/123/TumorCenter_CD8_block12_x4_y11_patient123_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15716.7, + "Centroid Y µm": 36805.5, + "Num Detections": 22088, + "Num Negative": 20840, + "Num Positive": 1248, + "Positive %": 5.65, + "Num Positive per mm^2": 510.93 + } +} \ No newline at end of file diff --git a/123/history_text.txt b/123/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/123/icd_codes.txt b/123/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/123/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/123/ops_codes.txt b/123/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8a2503a8f3ed3cded0180e9f04ad0db6833289c5 --- /dev/null +++ b/123/ops_codes.txt @@ -0,0 +1 @@ +Permanente Tracheotomie[5-312.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] Transplantat[5-295.14 ] Entnahme myokutaner Lappen mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.28 R] Transplantation myokutaner Lappen mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.78 R] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/123/patient_clinical_data.json b/123/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3b59ed2abf826cfb47d28536ea357823682a5061 --- /dev/null +++ b/123/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 40, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": null, + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/123/patient_pathological_data.json b/123/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1d102e048f842c0783282d7738e863fab324836f --- /dev/null +++ b/123/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "123", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/123/surgery_description.txt b/123/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..de187abf71dbacafdc7196f41c13718b30b7b1b4 --- /dev/null +++ b/123/surgery_description.txt @@ -0,0 +1 @@ +Total laryngectomy, Tracheotomy, Provox Prosthesis diff --git a/123/surgery_report.txt b/123/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9f824b7aee2c5f3108d711e9b5930ca7d5f23401 --- /dev/null +++ b/123/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first mark the apron flap. Incise it and lift it above the hyoid bone. Then expose the front edge of the sternocleidomastoid muscle. A metastasis can be seen in region IV, which is partially attached to the muscle and also appears to be firmly connected to the vein. Opening of the vascular nerve sheath and protection of the artery and vagus nerve. Dissection of the internal jugular vein. This shows that the metastasis cannot be dissected from the vein wall in a healthy layer. Therefore, expose the vein caudally and cranially under the digaster muscle. Deposition of the vein there. Subsequent partial resection of the sternocleidomastoid muscle together with the metastasis left on the vein. The following neck dissection is completed by . Neck dissection on the left (/PJ): Showing the borders of the neck dissection planned from level II to V. The submandibular gland is shown here, the posterior venter of the digaster, the hypoglossal nerve, the accessorius nerve, the anterior border of the sternocleidomastoid muscle, cervical plexus, cervical vascular sheath with the internal jugular vein, the external and internal carotid arteries, the omohyoid muscle was dissected to the detachment of the larynx. The neck preparation is now dissected and removed, preserving the non-lymphatic structures from level II to V. Punctual hemostasis. Placement of a 10 Redon drain. Exposure and protection of the nervus accessorius and nervus hypoglossus until the end. Then dissection and removal of the superior thyroid artery and dissection of the carotid artery medially and detachment from the laryngeal skeleton. Cranial exposure of the lateral horn of the hyoid bone and removal of the suprahyoid musculature up to the middle. Then cut through the straight neck muscles on the thyroid gland. Then pass under the isthmus and ligate on both sides so that the anterior trachea is clearly exposed. Opening of the trachea between the 3rd and 4th tracheal clasp with insertion of an LE tube. Then dissection of the right thyroid lobe laterally. Now transition to the opposite side. In principle, the procedure is similar here. The only difference is that all non-lymphatic structures are preserved here. Dissection of the large caliber lingual artery and facial artery for subsequent anastomosis. After appropriate detachment of the laryngeal skeleton, the epiglottis is completely freed of mucosa ventrally up to the upper edge of the glottis. There the mucosa is incised and the entrance into the pharynx is made. The tumor on the right side of the hypopharynx is directly visible. First, release the larynx on the left side along the epiglottis, leaving out the previously released piriform sinus. The hypopharynx is then successively removed at a distance of about 1.5 cm from the tumor. After uniting the incisions from both sides postcricoidally and detaching the larynx caudally under the cricoid while preparing a caudally pedicled mucosal flap for the subsequent Herrmann chimney, the larynx together with the right hypopharynx is removed in toto. Subsequently, marginal sections are taken from the resulting mucosal margins, all of which are found to be free of tumor and dysplasia in the frozen section histological examination. Then completion of the Herrmann chimney by suturing the mucosal flap to the upper tracheal clasp. Subsequent myotomy of the constrictor pharyngis muscle. Insertion of a Provox-Vega voice prosthesis. Again, completion of the neck dissection on the left side by . Neck dissection on the right (/PJ): Showing the borders of the nervus accessorius, cervical vascular sheath, omohyoid muscle, which was cut to detach the larynx, glandula submandibularis, venter posterior of the digaster. The anterior border of the sternocleidomastoid muscle is exposed after creation of the apron flap. There is a metastasis in level IV, which cannot be dissected from the internal jugular vein. After demonstrating the findings to , the decision is made to remove the internal jugular vein. The jugular vein is thus integrated into the preparation. Exposure of the vagus nerve, exposure of the common carotid artery, internal carotid artery, external carotid artery. All of the above structures can be spared. Release of the neck preparation of level II a, II b, III, IV and V. Punctual hemostasis and placement of a 10 Redon drainage. The ALT flap is then applied on the right side with a size of 4 x 9 cm. After Doppler sonographic visualization of the perforators, the flap is outlined and incised caudally medially down to the muscle fascia. Expose the muscle septum with medialization of the vastus medialis muscle. Then widen the incision cranially so that the vascular pedicle is clearly visible. Then cut around the flap medially cranially and caudally laterally. Finally, the stalk is also exposed distally at the end of the flap and removed. The flap is thus successively developed cranially with a muscle cuff. Finally, fine dissection of the pedicle is performed, whereby the vein and artery are exposed as far as their exit from the circumflex femoral artery. Once the neck dissection is complete, the flap is removed, rinsed with heparin solution and transferred to the neck. There the reconstruction of the hypopharynx is performed using single-button sutures. The flap is then anastomosed to the lingual artery on the left side and to the internal jugular vein. Conclusion: Hypopharyngeal/laryngeal carcinoma on the right with total laryngectomy with hemipharyngectomy, primary voice rehabilitation by implantation of a Provox voice prosthesis, pharyngeal reconstruction with a microvascularly anastomosed ALT flap from the right thigh, radical neck dissection on the right and selective neck dissection on the left, PEG placement. \ No newline at end of file diff --git a/124/InvasionFront_CD3_block4_x3_y4_patient124_0.json b/124/InvasionFront_CD3_block4_x3_y4_patient124_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3d4d13e7b5c2c769a9cc98b7492d15a03fe270d6 --- /dev/null +++ b/124/InvasionFront_CD3_block4_x3_y4_patient124_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 16166.4, + "Num Detections": 15908, + "Num Negative": 14377, + "Num Positive": 1531, + "Positive %": 9.624, + "Num Positive per mm^2": 667.16 + } +} \ No newline at end of file diff --git a/124/InvasionFront_CD3_block4_x4_y4_patient124_1.json b/124/InvasionFront_CD3_block4_x4_y4_patient124_1.json new file mode 100644 index 0000000000000000000000000000000000000000..01870853a72e10ac16d5a04961002eecf57eed96 --- /dev/null +++ b/124/InvasionFront_CD3_block4_x4_y4_patient124_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 16166.4, + "Num Detections": 16491, + "Num Negative": 15647, + "Num Positive": 844, + "Positive %": 5.118, + "Num Positive per mm^2": 391.32 + } +} \ No newline at end of file diff --git a/124/InvasionFront_CD8_block4_x3_y4_patient124_0.json b/124/InvasionFront_CD8_block4_x3_y4_patient124_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ba4035e4bc7cab0ac586fd57f0b07c614ab5762 --- /dev/null +++ b/124/InvasionFront_CD8_block4_x3_y4_patient124_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11452.9, + "Centroid Y µm": 14856.9, + "Num Detections": 15739, + "Num Negative": 14288, + "Num Positive": 1451, + "Positive %": 9.219, + "Num Positive per mm^2": 616.09 + } +} \ No newline at end of file diff --git a/124/InvasionFront_CD8_block4_x4_y4_patient124_1.json b/124/InvasionFront_CD8_block4_x4_y4_patient124_1.json new file mode 100644 index 0000000000000000000000000000000000000000..19a314566e958ce1c6e0b3dc95aa0888b85866f8 --- /dev/null +++ b/124/InvasionFront_CD8_block4_x4_y4_patient124_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13874.0, + "Centroid Y µm": 14918.0, + "Num Detections": 16549, + "Num Negative": 15672, + "Num Positive": 877, + "Positive %": 5.299, + "Num Positive per mm^2": 402.43 + } +} \ No newline at end of file diff --git a/124/TumorCenter_CD3_block4_x3_y4_patient124_0.json b/124/TumorCenter_CD3_block4_x3_y4_patient124_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5244020166cedc7442ab33690ff5e53ed1e450e6 --- /dev/null +++ b/124/TumorCenter_CD3_block4_x3_y4_patient124_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 10294.5, + "Num Detections": 14718, + "Num Negative": 13676, + "Num Positive": 1042, + "Positive %": 7.08, + "Num Positive per mm^2": 496.06 + } +} \ No newline at end of file diff --git a/124/TumorCenter_CD3_block4_x4_y4_patient124_1.json b/124/TumorCenter_CD3_block4_x4_y4_patient124_1.json new file mode 100644 index 0000000000000000000000000000000000000000..68224baf724489ecec39b864c13effd691a56950 --- /dev/null +++ b/124/TumorCenter_CD3_block4_x4_y4_patient124_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 10169.6, + "Num Detections": 15230, + "Num Negative": 14200, + "Num Positive": 1030, + "Positive %": 6.763, + "Num Positive per mm^2": 509.78 + } +} \ No newline at end of file diff --git a/124/TumorCenter_CD8_block4_x3_y4_patient124_0.json b/124/TumorCenter_CD8_block4_x3_y4_patient124_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d768caf2301c01279dcfeaa39fb1e5d54d27e341 --- /dev/null +++ b/124/TumorCenter_CD8_block4_x3_y4_patient124_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11843.7, + "Centroid Y µm": 10069.7, + "Num Detections": 15473, + "Num Negative": 14359, + "Num Positive": 1114, + "Positive %": 7.2, + "Num Positive per mm^2": 552.59 + } +} \ No newline at end of file diff --git a/124/TumorCenter_CD8_block4_x4_y4_patient124_1.json b/124/TumorCenter_CD8_block4_x4_y4_patient124_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a9c4b1d2c09fbca917a657715185ebe96403ace4 --- /dev/null +++ b/124/TumorCenter_CD8_block4_x4_y4_patient124_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14667.2, + "Centroid Y µm": 10269.6, + "Num Detections": 15943, + "Num Negative": 15233, + "Num Positive": 710, + "Positive %": 4.453, + "Num Positive per mm^2": 357.26 + } +} \ No newline at end of file diff --git a/124/history_text.txt b/124/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8e882cb17b5230222f10edeb1df1572bf34d53ae --- /dev/null +++ b/124/history_text.txt @@ -0,0 +1 @@ +The patient has a mass in the glossotonsillar fold with transition to the above-mentioned regions. Histological confirmation of a papillary carcinoma in situ as part of a panendoscopy and sampling on <2016> in domo. There is now an indication for resection. In addition, at the beginning of the operation, an approx. 1 cm large, flat, whitish thickened mass was noticed on the underside of the tongue on the front left, which was also removed. The indication for the above-mentioned procedure is therefore given. \ No newline at end of file diff --git a/124/icd_codes.txt b/124/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4c703dabc73ba2637d12288ffb4371f0744dcace --- /dev/null +++ b/124/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 R] Verhornungsstörung der Zunge[K13.2 L] \ No newline at end of file diff --git a/124/ops_codes.txt b/124/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f62361f8054fdb7e25489577a3c69adbb183b6d --- /dev/null +++ b/124/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Exzision und Destruktion erkranktes Gewebe Pharynx[5-292.x ] Exzision an der Zunge[5-250.2 ] Reoperation[5-983 ] \ No newline at end of file diff --git a/124/patient_clinical_data.json b/124/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5e5ff17114964bae361eb656516f3c0faa40fba5 --- /dev/null +++ b/124/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 85, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/124/patient_pathological_data.json b/124/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..286d24007a131fa1a984bc914f64a9b0ab0097b7 --- /dev/null +++ b/124/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "124", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/124/surgery_description.txt b/124/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..689e5211d4c6d8f4ad13e06e9c1034b1f3df0757 --- /dev/null +++ b/124/surgery_description.txt @@ -0,0 +1 @@ +Tumor excision diff --git a/124/surgery_report.txt b/124/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..35d9a4975a190536319b3107d638388249ebfaa8 --- /dev/null +++ b/124/surgery_report.txt @@ -0,0 +1 @@ +First bring the patient into the operating room and actively identify the patient. Then carry out the team time-out. Induction of anesthesia and intubation by the anesthesia colleagues. The surgeon now positions the patient. Inspection and palpation of the oral cavity and tongue. As described above, there is a 1 cm large mass on the underside of the tongue on the left anterior side. Furthermore, the papillomatous mass on the glossotonsillar fold on the right side measuring approx. 2 x 1 cm. Directly anterior to this, clearly hyperkeratotic, leukoplakically altered underside of the tongue and tongue surface in the posterior third of the tongue reaching up to the gingiva, which appears suspicious and is directly related to the papillomatous mass. Therefore, excision of the papillomatous mass with the leukoplakic mucosal change in toto. Marking using bipolar. Subsequent excision in toto using a monopolar needle. Several marginal samples are taken (surface of the tongue, undersurface of the tongue, posteriorly and at the base of the wound). Excision of the mass on the anterior underside of the tongue and, after bipolar hemostasis, suturing in this area. After one hour, the frozen section is made: Here, high-grade dysplasia is seen focally in the posterior margin. Therefore, a large incision (2 x 1 cm) is made here and then a marginal sample is sent for final histology. The result is an approx. 5 x 3 cm wound area on the right posterior third of the tongue, soft palate, tonsil lobe and gingiva. Only anterior adaptation of the wound edges using individual Vicryl 3.0 SH sutures. Subsequent bipolar hemostasis and, under dry conditions, completion of the operation without complications. Conclusion: Excision of papillary carcinoma in situ upper and lower posterior tongue, glossotonsillar fold, posterior gingiva and tonsillar lobe on the right with rapid incision in ITN. Excision of a hyperkeratosis on the left anterior side of the underside of the tongue with primary wound closure. Please wait for the final histology, the post-resection and the final margin sample and then present again at our tumor conference. \ No newline at end of file diff --git a/125/InvasionFront_CD3_block12_x5_y8_patient125_0.json b/125/InvasionFront_CD3_block12_x5_y8_patient125_0.json new file mode 100644 index 0000000000000000000000000000000000000000..99b1ccd39c19c9361db2a3c8f153767b989104e1 --- /dev/null +++ b/125/InvasionFront_CD3_block12_x5_y8_patient125_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 25036.7, + "Num Detections": 19017, + "Num Negative": 18167, + "Num Positive": 850, + "Positive %": 4.47, + "Num Positive per mm^2": 393.99 + } +} \ No newline at end of file diff --git a/125/InvasionFront_CD3_block12_x6_y8_patient125_1.json b/125/InvasionFront_CD3_block12_x6_y8_patient125_1.json new file mode 100644 index 0000000000000000000000000000000000000000..edd45488fd995bc000caea7b2d57d6551752c435 --- /dev/null +++ b/125/InvasionFront_CD3_block12_x6_y8_patient125_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 25286.6, + "Num Detections": 19155, + "Num Negative": 17965, + "Num Positive": 1190, + "Positive %": 6.212, + "Num Positive per mm^2": 546.9 + } +} \ No newline at end of file diff --git a/125/InvasionFront_CD8_block12_x5_y8_patient125_0.json b/125/InvasionFront_CD8_block12_x5_y8_patient125_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4066e538634fe7846fc442e315c97ecbb1930f0e --- /dev/null +++ b/125/InvasionFront_CD8_block12_x5_y8_patient125_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17465.8, + "Centroid Y µm": 23637.5, + "Num Detections": 19520, + "Num Negative": 18827, + "Num Positive": 693, + "Positive %": 3.55, + "Num Positive per mm^2": 315.28 + } +} \ No newline at end of file diff --git a/125/InvasionFront_CD8_block12_x6_y8_patient125_1.json b/125/InvasionFront_CD8_block12_x6_y8_patient125_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3cf144906d5d23fac35d4d410cfad686b3905bdc --- /dev/null +++ b/125/InvasionFront_CD8_block12_x6_y8_patient125_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20089.4, + "Centroid Y µm": 23587.5, + "Num Detections": 18597, + "Num Negative": 17926, + "Num Positive": 671, + "Positive %": 3.608, + "Num Positive per mm^2": 307.06 + } +} \ No newline at end of file diff --git a/125/TumorCenter_CD3_block12_x5_y8_patient125_0.json b/125/TumorCenter_CD3_block12_x5_y8_patient125_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad6e3f90774fef1ce1e9ff3a57eb44591a6f9204 --- /dev/null +++ b/125/TumorCenter_CD3_block12_x5_y8_patient125_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15666.7, + "Centroid Y µm": 20114.3, + "Num Detections": 18732, + "Num Negative": 16577, + "Num Positive": 2155, + "Positive %": 11.5, + "Num Positive per mm^2": 988.37 + } +} \ No newline at end of file diff --git a/125/TumorCenter_CD3_block12_x6_y8_patient125_1.json b/125/TumorCenter_CD3_block12_x6_y8_patient125_1.json new file mode 100644 index 0000000000000000000000000000000000000000..929457e619c7c515924f6334d0fc6bf523f56d5b --- /dev/null +++ b/125/TumorCenter_CD3_block12_x6_y8_patient125_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18090.4, + "Centroid Y µm": 20139.3, + "Num Detections": 17894, + "Num Negative": 16967, + "Num Positive": 927, + "Positive %": 5.181, + "Num Positive per mm^2": 440.94 + } +} \ No newline at end of file diff --git a/125/TumorCenter_CD8_block12_x5_y8_patient125_0.json b/125/TumorCenter_CD8_block12_x5_y8_patient125_0.json new file mode 100644 index 0000000000000000000000000000000000000000..047ea71176d715ac8d68960f61c9e1a3aac9b977 --- /dev/null +++ b/125/TumorCenter_CD8_block12_x5_y8_patient125_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 29634.3, + "Num Detections": 18257, + "Num Negative": 17014, + "Num Positive": 1243, + "Positive %": 6.808, + "Num Positive per mm^2": 586.72 + } +} \ No newline at end of file diff --git a/125/TumorCenter_CD8_block12_x6_y8_patient125_1.json b/125/TumorCenter_CD8_block12_x6_y8_patient125_1.json new file mode 100644 index 0000000000000000000000000000000000000000..38a977751474e943b9e2a79978468986848d2463 --- /dev/null +++ b/125/TumorCenter_CD8_block12_x6_y8_patient125_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21213.8, + "Centroid Y µm": 29784.2, + "Num Detections": 16870, + "Num Negative": 16668, + "Num Positive": 202, + "Positive %": 1.197, + "Num Positive per mm^2": 105.18 + } +} \ No newline at end of file diff --git a/125/history_text.txt b/125/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b2aad6584452f640eedcf5466c248a4cb110ffde --- /dev/null +++ b/125/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma cT2 to 3. Thyroid cartilage infiltration recognizable. \ No newline at end of file diff --git a/125/icd_codes.txt b/125/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/125/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/125/ops_codes.txt b/125/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..19c8500b31ea4735ce2598641e28f12d489abcc2 --- /dev/null +++ b/125/ops_codes.txt @@ -0,0 +1 @@ +Andere partielle Laryngektomie: Partielle Larynx-Pharynx-Resektion[5-302.4 ] Pharyngoplastik: Mit gestieltem myokutanen Lappen[5-293.1 ] Plastische Rekonstruktion mit lokalen Lappen an Muskeln und Faszien: Myokutaner Lappen, gefäßgestielt: Kopf und Hals[5-857.70 L] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 B] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Resektion, partiell: Durch Pharyngotomie[5-292.11 ] \ No newline at end of file diff --git a/125/patient_clinical_data.json b/125/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..24b0c0f6abb6246613012f6f7c1c5eeb06fb3878 --- /dev/null +++ b/125/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 44, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/125/patient_pathological_data.json b/125/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..59f37884ba2649f9686d90a1c5f56a30d6f86301 --- /dev/null +++ b/125/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "125", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/125/surgery_description.txt b/125/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d89dec1f65fa13a80e16bd04521a36452ccd9688 --- /dev/null +++ b/125/surgery_description.txt @@ -0,0 +1 @@ +Resection, Bilateral neck dissection, PEG placement, Tracheostomy creation, Defect coverage, Free flap (Radial) diff --git a/125/surgery_report.txt b/125/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d2ef52cd41f0a9859d78af8a36ffcd69db743419 --- /dev/null +++ b/125/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and larygoscopy again: The exophytic tumor is visible, which has not affected the hypopharyngeal side wall up to the midline, the anterior piriform sinus wall and parts of the arytenoid fold on the left. However, the arytenoid cartilage area and postcricoid area are free, as is the tip of the piriform sinus. Right piriform sinus also free, findings are demonstrated again . Attempt to cover the defect using a platysmal flap or lateral thigh flap. Now first PEG insertion: advancement of the esophagoscope into the stomach, good diaphanoscopy after pre-operation and insertion of a 9-gauge abdominal wall tube without complications. Subsequent repositioning for neck dissection and tumor resection: injection of a total of 8 ml xylocaine 1% with adrenaline. Skin disinfection. Now first radical neck dissection with elevation of the platysmal flap. First mark the supraclavicular platysmal flap with a size of 9 x 5 cm. Then .............. the skin island and dissection of the flap pedicle with adjacent subcutaneous tissue, leading veins are preserved. The large infiltrating nodus can be easily dissected from a separating layer. Now dissect the sternocleidomastoid muscle, which is infiltrated by the nodule. Dissect the omohyoid muscle, the digastric muscle and the submandibular gland. The capsule of the gland is removed. The anterior neck area is now cleared out in the block. The carotid artery and vagus nerve, which are not infiltrated, are also exposed. Exposure of the internal jugular vein. This is infiltrated by the tumor node below the outlet of the facial vein, which is also dissected. It is therefore placed near the outlet to the facial vein and ligated twice. It is also removed caudally and ligated twice. The sternocleidomastoid muscle is removed anteriorly. First expose the accessorius nerve which is not infiltrated. Below the entry of the accessorius nerve into the sternocleidomastoid muscle, the muscle is removed cranially. This is followed by tumor resection via lateral pharyngotomy and partial pharyngeal-laryngeal resection: exposure of the pharyngeal tube, dissection of the constrictor pharyngis muscle. Exposure of the hypoglossal nerve, superior thyroid artery which is preserved and the superior laryngeal nerve which is also preserved. Thyroid gland is dissected away slightly caudo-laterally. Entering the larynx at the level of the hyoid bone, after exposing the tumor it is incised on all sides with a safety margin of approx. 1 cm. The piriform sinus is triggered by the thyroid cartilage. This is partially resected. Resection extends cranially to the level of the base of the tongue, medially to the epiglottis, the aryepiglottic fold is resected medially, the arytenoid cartilage remains in situ. The postcricoid area is not touched, the piriform sinus is resected anteriorly and laterally. Marginal samples are taken from the lateral pharyngeal wall, the medial pharyngeal wall, the arytenoid area and caudally from the piriform sinus. These are thread-marked and sent to the frozen section. In the frozen section, no reliable assessment or exclusion is possible medially in the pharyngeal region. All other marginal samples are tumor-free (). Another marginal sample is therefore taken medially from the pharynx or epiglottis margin down to the arytenoid region. This is again thread-marked for frozen section. Now no more tumor tissue detectable (). R0 resection can therefore not be assumed. The platysmal flap is now sutured into the defect. The flap has a good vital aspect before suturing. Suturing is performed using 3.0 Vicryl single button sutures without tension. The flap is then irrigated again with H202 and Ringer's solution and the bleeding is carefully stopped. The tracheotomy is performed: the incision is extended medially over the trachea. Then dissection up to the in..................... muscles, splitting of these, exposure of the trachea, isthmus barely present. Entry into the 2nd/3rd intercartilaginous space with creation of a visor flap and epithelization of this. Then skin displacement and wound closure on the left with insertion of a Redon drainage. Neck dissection on the right: skin incision in front of the sternocleidomastoid muscle. Dissection of the lymph node fat preparation from the muscle. Exposure of the omohyoid muscle, digastric muscle, internal jugular vein, carotid artery, vagus nerve and accessorius nerve. Development of the dorsal neck preparation and preservation of the branches of the cervical plexus. Then separate the anterior neck preparation, exposing and preserving the superior thyroid artery, the hypoglossal nerve and the cervical nerve. Irrigation with H202 and Ringer's solution and careful hemostasis. Wound closure with insertion of a Redon drain. Further reintubation, a tracheal cannula was inserted. Patient goes to the intensive care unit for postoperative monitoring. Patient received 3 g Unacid i.v. intraoperatively. Please continue this antibiotic treatment for one week. Please feed for 10 days via PEG or via the inserted gastric tube. After 10 days, please take an X-ray and, if necessary, rebuild the diet. \ No newline at end of file diff --git a/126/InvasionFront_CD3_block13_x1_y11_patient126_0.json b/126/InvasionFront_CD3_block13_x1_y11_patient126_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5eb0044bb93d72e89390c1ff6a42206c47a04f3d --- /dev/null +++ b/126/InvasionFront_CD3_block13_x1_y11_patient126_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 26436.0, + "Num Detections": 23952, + "Num Negative": 22281, + "Num Positive": 1671, + "Positive %": 6.976, + "Num Positive per mm^2": 652.82 + } +} \ No newline at end of file diff --git a/126/InvasionFront_CD3_block13_x2_y11_patient126_1.json b/126/InvasionFront_CD3_block13_x2_y11_patient126_1.json new file mode 100644 index 0000000000000000000000000000000000000000..50b7b86935bbb2d27eeaed8bc8b2abd4905935a8 --- /dev/null +++ b/126/InvasionFront_CD3_block13_x2_y11_patient126_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 26511.0, + "Num Detections": 17792, + "Num Negative": 17488, + "Num Positive": 304, + "Positive %": 1.709, + "Num Positive per mm^2": 170.5 + } +} \ No newline at end of file diff --git a/126/InvasionFront_CD8_block13_x1_y11_patient126_0.json b/126/InvasionFront_CD8_block13_x1_y11_patient126_0.json new file mode 100644 index 0000000000000000000000000000000000000000..18ad3731158e21afc1ed3d53d9c64ff1cf4a943f --- /dev/null +++ b/126/InvasionFront_CD8_block13_x1_y11_patient126_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 28135.1, + "Num Detections": 25097, + "Num Negative": 20951, + "Num Positive": 4146, + "Positive %": 16.52, + "Num Positive per mm^2": 1571.9 + } +} \ No newline at end of file diff --git a/126/InvasionFront_CD8_block13_x2_y11_patient126_1.json b/126/InvasionFront_CD8_block13_x2_y11_patient126_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3fa63af910005c89437be0cfb1c4c1254e246c37 --- /dev/null +++ b/126/InvasionFront_CD8_block13_x2_y11_patient126_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6771.4, + "Centroid Y µm": 28260.0, + "Num Detections": 19197, + "Num Negative": 18720, + "Num Positive": 477, + "Positive %": 2.485, + "Num Positive per mm^2": 256.94 + } +} \ No newline at end of file diff --git a/126/TumorCenter_CD3_block13_x1_y11_patient126_0.json b/126/TumorCenter_CD3_block13_x1_y11_patient126_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1fe87095831ea0dde49dc56f46ce932e091599ca --- /dev/null +++ b/126/TumorCenter_CD3_block13_x1_y11_patient126_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3498.1, + "Centroid Y µm": 33357.3, + "Num Detections": 21795, + "Num Negative": 18547, + "Num Positive": 3248, + "Positive %": 14.9, + "Num Positive per mm^2": 1376.1 + } +} \ No newline at end of file diff --git a/126/TumorCenter_CD3_block13_x2_y11_patient126_1.json b/126/TumorCenter_CD3_block13_x2_y11_patient126_1.json new file mode 100644 index 0000000000000000000000000000000000000000..99451e538ad6679f0fbc202fc5f241b2c5e89613 --- /dev/null +++ b/126/TumorCenter_CD3_block13_x2_y11_patient126_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 33632.2, + "Num Detections": 24566, + "Num Negative": 20176, + "Num Positive": 4390, + "Positive %": 17.87, + "Num Positive per mm^2": 1642.6 + } +} \ No newline at end of file diff --git a/126/TumorCenter_CD8_block13_x1_y11_patient126_0.json b/126/TumorCenter_CD8_block13_x1_y11_patient126_0.json new file mode 100644 index 0000000000000000000000000000000000000000..76399d32bcca7200de826979300be57a643bc0b0 --- /dev/null +++ b/126/TumorCenter_CD8_block13_x1_y11_patient126_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 28160.1, + "Num Detections": 21985, + "Num Negative": 19531, + "Num Positive": 2454, + "Positive %": 11.16, + "Num Positive per mm^2": 1076.3 + } +} \ No newline at end of file diff --git a/126/TumorCenter_CD8_block13_x2_y11_patient126_1.json b/126/TumorCenter_CD8_block13_x2_y11_patient126_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4587dd657bed699150ba43534ab85c9c3fb9151e --- /dev/null +++ b/126/TumorCenter_CD8_block13_x2_y11_patient126_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8695.4, + "Centroid Y µm": 27810.3, + "Num Detections": 24999, + "Num Negative": 20513, + "Num Positive": 4486, + "Positive %": 17.94, + "Num Positive per mm^2": 1704.0 + } +} \ No newline at end of file diff --git a/126/history_text.txt b/126/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/126/icd_codes.txt b/126/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c935d7eae58466b4e7ef3d21ca06a99151e82d83 --- /dev/null +++ b/126/icd_codes.txt @@ -0,0 +1 @@ +Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/126/ops_codes.txt b/126/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c78ffb3545c8e029ccdb222da714f47204f2fbbd --- /dev/null +++ b/126/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] Partielle Resektion des Pharynx [Pharynxteilresektion] onA[5-295.y ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 R] Selektive Neck dissection in 4 Regionen[5-403.03 L] Permanente Tracheotomie[5-312.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] \ No newline at end of file diff --git a/126/patient_clinical_data.json b/126/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..24c1c8eeadf896d3b44aaec9c6860017ff2b408c --- /dev/null +++ b/126/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 40, + "adjuvant_treatment_intent": "palliative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/126/patient_pathological_data.json b/126/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5ce7af167ff93d9a704dc13712a5ef90e2864293 --- /dev/null +++ b/126/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "126", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN2a", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/126/surgery_description.txt b/126/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..53d9b5b5c48c0d71483ee81c7025de15460e3daa --- /dev/null +++ b/126/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, Tracheotomy, Nasogastric tube diff --git a/126/surgery_report.txt b/126/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7f38b31d0956209832fd39d407058569407b5594 --- /dev/null +++ b/126/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation using a laser tube transorally by the anesthesia colleagues. First inspection of the tumor. The tumor infiltrates the entire right side of the vallecula, moves over to the opposite side, infiltrates deep into the base of the tongue on the left side as well, moves over to the side wall of the pharynx, thus progressing in size to the previous findings. Positioning of the tumor and demonstration on and . Joint consultation and decision on the planned laser resection. Preparation of the laser and start with 5 watts on the right side wall of the pharynx, then transition to cutting in the base of the tongue. The tumor is completely cut around the base of the tongue and also completely cut around the base of the tongue on the left side. Then removal of the epiglottis. The tumor can be resected en bloc and is suture-marked for a frozen section: carcinoma in situ in the lateral set-off area and at the base of the tongue. A generous resection is performed and marginal samples are taken from the middle of the tongue base, laterally and also from the lateral pharyngeal wall. Finally R0. Neck dissection on the left: Skin incision at the anterior margin of the sternocleidomastoid. Exposure of the sternocleidomastoid, the omohyoid, the cervical vascular sheath and the digaster as well as the submandibular gland, the accessorius and the hypoglossus. Unfortunately, the facial vein must be severed. Removal of the neck block II a to V a, sparing the plexus branches. Turning to the opposite side: Here also skin incision at the anterior edge of the sternocleidomastoid. Exposure of the sternocleidomastoid. It quickly becomes clear that a thick metastasis in the level II transition level III area is infiltrating the sternocleidomastoid. Therefore exposure of the cervical vascular sheath in the caudal region and removal of approx. ľ of the sternocleidomastoid muscle and dissection from caudal to cranial along the cervical vascular sheath. In the area of the tumor, it can be clearly seen that the tumor also infiltrates the jugular vein. This must therefore be removed here. On the opposite side, the jugular vein could be kept completely intact. The tumor is pushed away from the internal carotid artery. The superior thyroid vein infiltrates completely into the metastasis and is deposited at the exit from the external carotid artery. The hypoglossus, which can be pushed away by the tumor, and the digaster of the submandibular gland are then shown. Finally, the entire metastasis can be removed, taking the internal jugular vein with it. The internal jugular vein is thrombosed and closed so that it no longer bleeds in the cranial area even when it is removed. Nevertheless, the cranial area is ligated. Then removal of the remaining neck preparation level II b, III, IV and V, sparing the remaining plexus branches, although a large part of the plexus branches including the accessorius nerve were also removed. The facial vein and external jugular vein were also ligated. Insertion of Redon drains. Two-layer wound closure on both sides. Tracheotomy: The tracheotomy, as well as the neck dissection on both sides, is difficult with a short, very fatty neck. Ligation of the anterior jugular vein on both sides. Exposure of the musculature. Dissection of the musculature. Exposure of the thyroid isthmus and undermining of the thyroid isthmus. Coagulation of the thyroid isthmus and visualization of the trachea. Insertion between the 2nd and 3rd tracheal cartilage. Creation of a visor tracheotomy and reintubation. The patient goes to the intensive care unit tracheotomized. Please feed via nasogastric tube for 1 week, then attempt to swallow and build up diet. \ No newline at end of file diff --git a/127/InvasionFront_CD3_block20_x1_y7_patient127_0.json b/127/InvasionFront_CD3_block20_x1_y7_patient127_0.json new file mode 100644 index 0000000000000000000000000000000000000000..56dcc6e06147a8d686776713b3973aa3809c5dd1 --- /dev/null +++ b/127/InvasionFront_CD3_block20_x1_y7_patient127_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4597.6, + "Centroid Y µm": 16941.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/127/InvasionFront_CD3_block20_x2_y7_patient127_1.json b/127/InvasionFront_CD3_block20_x2_y7_patient127_1.json new file mode 100644 index 0000000000000000000000000000000000000000..908d6ff87635f2d24e43aed9bea22e4adc5b6f02 --- /dev/null +++ b/127/InvasionFront_CD3_block20_x2_y7_patient127_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7296.1, + "Centroid Y µm": 17066.0, + "Num Detections": 15140, + "Num Negative": 14848, + "Num Positive": 292, + "Positive %": 1.929, + "Num Positive per mm^2": 174.69 + } +} \ No newline at end of file diff --git a/127/InvasionFront_CD8_block20_x1_y7_patient127_0.json b/127/InvasionFront_CD8_block20_x1_y7_patient127_0.json new file mode 100644 index 0000000000000000000000000000000000000000..57a66bfc67b7959c855770ac48713a6e9086302f --- /dev/null +++ b/127/InvasionFront_CD8_block20_x1_y7_patient127_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4597.6, + "Centroid Y µm": 17965.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/127/InvasionFront_CD8_block20_x2_y7_patient127_1.json b/127/InvasionFront_CD8_block20_x2_y7_patient127_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d4f60172e147bc1cdbf1baa755eb1d8d86b10996 --- /dev/null +++ b/127/InvasionFront_CD8_block20_x2_y7_patient127_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7021.3, + "Centroid Y µm": 17865.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/127/TumorCenter_CD3_block20_x1_y7_patient127_0.json b/127/TumorCenter_CD3_block20_x1_y7_patient127_0.json new file mode 100644 index 0000000000000000000000000000000000000000..55ec6e9041e5e385c818834da3d351141bd24776 --- /dev/null +++ b/127/TumorCenter_CD3_block20_x1_y7_patient127_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3662.3, + "Centroid Y µm": 16808.0, + "Num Detections": 16340, + "Num Negative": 16311, + "Num Positive": 29, + "Positive %": 0.1775, + "Num Positive per mm^2": 14.16 + } +} \ No newline at end of file diff --git a/127/TumorCenter_CD3_block20_x2_y7_patient127_1.json b/127/TumorCenter_CD3_block20_x2_y7_patient127_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ca121033d38670010bf80c2a8e73d6fad05c99df --- /dev/null +++ b/127/TumorCenter_CD3_block20_x2_y7_patient127_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6245.0, + "Centroid Y µm": 16848.4, + "Num Detections": 13922, + "Num Negative": 13726, + "Num Positive": 196, + "Positive %": 1.408, + "Num Positive per mm^2": 89.9 + } +} \ No newline at end of file diff --git a/127/TumorCenter_CD8_block20_x1_y7_patient127_0.json b/127/TumorCenter_CD8_block20_x1_y7_patient127_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8742fa3d52cb5df6316077b34a14c0ffcc45f60c --- /dev/null +++ b/127/TumorCenter_CD8_block20_x1_y7_patient127_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 17990.5, + "Num Detections": 22728, + "Num Negative": 22498, + "Num Positive": 230, + "Positive %": 1.012, + "Num Positive per mm^2": 106.94 + } +} \ No newline at end of file diff --git a/127/TumorCenter_CD8_block20_x2_y7_patient127_1.json b/127/TumorCenter_CD8_block20_x2_y7_patient127_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d90a7e7518cd571d989a458a024264d423e689c2 --- /dev/null +++ b/127/TumorCenter_CD8_block20_x2_y7_patient127_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 17815.6, + "Num Detections": 11772, + "Num Negative": 11077, + "Num Positive": 695, + "Positive %": 5.904, + "Num Positive per mm^2": 547.54 + } +} \ No newline at end of file diff --git a/127/history_text.txt b/127/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..62e13e62dbb8af29d7565830ee38aa28987cc5ea --- /dev/null +++ b/127/history_text.txt @@ -0,0 +1 @@ + has a histologically confirmed squamous cell carcinoma of both vocal folds and anterior commissure. Preoperative panendoscopy revealed a squamous cell carcinoma of the anterior and middle vocal fold on the left and anterior commissure and anterior 1/3 vocal fold on the right. Intraoperative CT imaging showed no evidence of infiltration of the thyroid cartilage. Although a frontolateral laryngeal resection from the outside was planned, an endoscopic laser resection was preferred due to the incipient tumor stage and good visualization (indication ). \ No newline at end of file diff --git a/127/icd_codes.txt b/127/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4a465a3825558d37a19ac2e37267c159075ccc15 --- /dev/null +++ b/127/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Bösartige Neubildung der Glottis[C32.0 B] \ No newline at end of file diff --git a/127/ops_codes.txt b/127/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..12d96da5b9b201833c3ef1663500d7ed5862831d --- /dev/null +++ b/127/ops_codes.txt @@ -0,0 +1 @@ +CO2-Lasertechnik[5-985.1 ] Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/127/patient_clinical_data.json b/127/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9aa18809794461e938334a27efb85f7fcc07088b --- /dev/null +++ b/127/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/127/patient_pathological_data.json b/127/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4e40060337f12c174cb7547ff9cc2700fa1d37ff --- /dev/null +++ b/127/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "127", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1b", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.8 +} \ No newline at end of file diff --git a/127/surgery_description.txt b/127/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0cbdc6a64cad57d9388aa287968718539b7ebbc --- /dev/null +++ b/127/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection, Tracheotomy diff --git a/127/surgery_report.txt b/127/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a5bce6d3ad01388683e05d8c421c09dcc4f3add3 --- /dev/null +++ b/127/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleague, the patient is repositioned by . Insertion of several moist compresses to protect the oral structures in edentulous status. Insertion of the size B small ear canal into the larynx and visualization of the glottic plane. Acquisition of . This showed a clinically glottic carcinoma (cT1b), predominantly on the left, comprising the middle and anterior third of the vocal fold on the left, anterior commissure and up to 2 mm anterior 1/3 of the vocal fold on the right. Questionable infiltration of the sinus morgagni on the left side. Then reintubation by the anesthesia colleague in preparation for laser resection. Repositioning with the size B Kleinsasser tube. Now marking of the laser resection from the inside using a CO2 laser. Marking is performed approx. 0.5 cm from the tumor margins. This is followed by laser resection using a CO2 laser in superpulse mode with 6.0 watts. Start of the resection from the back. The resection is performed from the adenoid on the left and the aryepiglottic fold to the front and caudally. Resection through all layers up to the thyroid lamina and inner perichondrium. The posterior resection is extended approx. 6 to 7 mm subglottically. After identification of the inner perichondrium, the complete pocket fold and vocal fold on the left are lasered off. Further preparation until identification of the ligamentum broyle to the front. Then transition via anterior commissure superglottic right. Approx. 0.5 cm of the anterior commissure is removed here. The laser resection is extended anteriorly approx. 3-4 mm subglottically. The entire preparation is removed in toto. Then 2 marginal samples are taken: 1) caudal sample, 2) anterior commissure. All 3 specimens are marked and sent for histologic frozen section examination. During the waiting period, hemostasis is performed using suprarenin-soaked swabs. Removal of the Kleinsasser tube and preparation for tracheostomy. Then positioning of the patient in a slightly hyperextended head position by . Skin disinfection. Local infiltration anesthesia with approx. 4.5 ml mixed solution of Suprarenin and Ultracaine. Sterile rinsing and covering. Make a skin incision measuring up to 3 cm horizontally between the cricoid cartilage and the jugulum. Sharp cutting of the skin, the subcutaneous fatty tissue and the platysma. Identification of the midline and linea alba. Separation of the infrahyoid muscles. Visualization of the thyroid isthmus. Undermining and mobilization of the thyroid isthmus cranially. Exposure of the middle cervical fascia. An opening of the trachea between the 3rd and 4th tracheal cartilage in the sense of a visor tracheotomy is performed. The tracheal edges are fixed with several sutures to the lower and upper skin. Insertion of a size 8 tracheal cannula. In the meantime, the results are communicated by the pathology colleague. Anterior commissure and caudal margin to the subglottis are described as tumor-free. Questionable infiltration towards the back. Acceptance of . A resection is performed in the area of the arytaenoid. Two strips of tissue are removed here. The first is removed from the arytenoid caudally and anteriorly practically up to the anterior commissure. The second is taken from the area of the middle arythenoid on the left. Both samples are sent for final histology. Hemostasis using monopolar coagulation and suprarenin-soaked swabs. End of the surgical procedure without complications. The patient is handed over to the anesthesia colleagues. Conclusion: Endoscopic transoral laser resection for a cT1b (predominantly left) glottic carcinoma. Additional temporary tracheostomy. Intraoperative frozen section diagnosis is described as tumor-free in the anterior commissure and subglottic area. In case of questionable infiltrations in the area of the arytaenoid, 2 marginal samples are taken. Please leave the blockable cannula in place for 5 days. Decannulation should be considered depending on the course of the procedure. Diet build-up from the 1st postoperative day. If there is significant clinical swallowing, a nasogastric tube should be inserted. Cannula change possible from the 2nd postoperative day. Further procedure after receipt of the histology. \ No newline at end of file diff --git a/128/InvasionFront_CD3_block16_x1_y4_patient128_0.json b/128/InvasionFront_CD3_block16_x1_y4_patient128_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0f3e255995b14f8aacbc7a5afc467cbb2db5b911 --- /dev/null +++ b/128/InvasionFront_CD3_block16_x1_y4_patient128_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4478.2, + "Centroid Y µm": 14378.1, + "Num Detections": 18412, + "Num Negative": 18103, + "Num Positive": 309, + "Positive %": 1.678, + "Num Positive per mm^2": 150.87 + } +} \ No newline at end of file diff --git a/128/InvasionFront_CD3_block16_x2_y4_patient128_1.json b/128/InvasionFront_CD3_block16_x2_y4_patient128_1.json new file mode 100644 index 0000000000000000000000000000000000000000..24fcf7c3d59cbd7f35ec25e07c563fd7c6f5aae3 --- /dev/null +++ b/128/InvasionFront_CD3_block16_x2_y4_patient128_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7086.6, + "Centroid Y µm": 14465.2, + "Num Detections": 22909, + "Num Negative": 22718, + "Num Positive": 191, + "Positive %": 0.8337, + "Num Positive per mm^2": 76.67 + } +} \ No newline at end of file diff --git a/128/InvasionFront_CD8_block16_x1_y4_patient128_0.json b/128/InvasionFront_CD8_block16_x1_y4_patient128_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8ad9377d615b53a5a1f2bd7993f6b424807d448c --- /dev/null +++ b/128/InvasionFront_CD8_block16_x1_y4_patient128_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3645.1, + "Centroid Y µm": 9582.1, + "Num Detections": 22287, + "Num Negative": 20201, + "Num Positive": 2086, + "Positive %": 9.36, + "Num Positive per mm^2": 851.21 + } +} \ No newline at end of file diff --git a/128/InvasionFront_CD8_block16_x2_y4_patient128_1.json b/128/InvasionFront_CD8_block16_x2_y4_patient128_1.json new file mode 100644 index 0000000000000000000000000000000000000000..13806b1220ef48c22d5755b9d31a62c8986fb533 --- /dev/null +++ b/128/InvasionFront_CD8_block16_x2_y4_patient128_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6240.3, + "Centroid Y µm": 9683.1, + "Num Detections": 23725, + "Num Negative": 23126, + "Num Positive": 599, + "Positive %": 2.525, + "Num Positive per mm^2": 233.89 + } +} \ No newline at end of file diff --git a/128/TumorCenter_CD3_block16_x1_y4_patient128_0.json b/128/TumorCenter_CD3_block16_x1_y4_patient128_0.json new file mode 100644 index 0000000000000000000000000000000000000000..764e64d3dd4e7cadadac67b10af6cee075b11067 --- /dev/null +++ b/128/TumorCenter_CD3_block16_x1_y4_patient128_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4672.5, + "Centroid Y µm": 9894.8, + "Num Detections": 22397, + "Num Negative": 20912, + "Num Positive": 1485, + "Positive %": 6.63, + "Num Positive per mm^2": 560.78 + } +} \ No newline at end of file diff --git a/128/TumorCenter_CD3_block16_x2_y4_patient128_1.json b/128/TumorCenter_CD3_block16_x2_y4_patient128_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6074d67a639b7f5a9c0212b842336cc89a9f6013 --- /dev/null +++ b/128/TumorCenter_CD3_block16_x2_y4_patient128_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7221.2, + "Centroid Y µm": 9969.7, + "Num Detections": 19910, + "Num Negative": 18518, + "Num Positive": 1392, + "Positive %": 6.991, + "Num Positive per mm^2": 579.77 + } +} \ No newline at end of file diff --git a/128/TumorCenter_CD8_block16_x1_y4_patient128_0.json b/128/TumorCenter_CD8_block16_x1_y4_patient128_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eacebcded2faea2e9f111b4f33d41c186261790d --- /dev/null +++ b/128/TumorCenter_CD8_block16_x1_y4_patient128_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3473.2, + "Centroid Y µm": 10319.5, + "Num Detections": 22646, + "Num Negative": 18887, + "Num Positive": 3759, + "Positive %": 16.6, + "Num Positive per mm^2": 1444.3 + } +} \ No newline at end of file diff --git a/128/TumorCenter_CD8_block16_x2_y4_patient128_1.json b/128/TumorCenter_CD8_block16_x2_y4_patient128_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d44e82ce296c3a7243979d82b601d049e2a037d6 --- /dev/null +++ b/128/TumorCenter_CD8_block16_x2_y4_patient128_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 10269.6, + "Num Detections": 20534, + "Num Negative": 18482, + "Num Positive": 2052, + "Positive %": 9.993, + "Num Positive per mm^2": 867.5 + } +} \ No newline at end of file diff --git a/128/history_text.txt b/128/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fec9a2c18035562d19f30b2ad9ba72fdf01080c4 --- /dev/null +++ b/128/history_text.txt @@ -0,0 +1 @@ +The patient has a post-excisional biopsy of a mass on the edge of the tongue which is non in sano in 2 places. Therefore indication for the above procedure. \ No newline at end of file diff --git a/128/icd_codes.txt b/128/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9e6a32e4d7ed758389d3525f593a2fd787a8ea14 --- /dev/null +++ b/128/icd_codes.txt @@ -0,0 +1 @@ +Karzinom des Zungenrandes und der Zungenspitze[C02.1 ] \ No newline at end of file diff --git a/128/ops_codes.txt b/128/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0d429bbdaa076a182091bd56a2fd04dc6ff79177 --- /dev/null +++ b/128/ops_codes.txt @@ -0,0 +1 @@ +Inzision erkranktes Gewebe Zungenrand[5-250.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] \ No newline at end of file diff --git a/128/patient_clinical_data.json b/128/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..46460e847c3de35d06452d475b331401161e542d --- /dev/null +++ b/128/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/128/patient_pathological_data.json b/128/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0e7b70ac76664bdfa581f9805149ff8822e8a165 --- /dev/null +++ b/128/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "128", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 17, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/128/surgery_description.txt b/128/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9326dc42b43fbaf5fe96d8b1ed97d0f7bdb04771 --- /dev/null +++ b/128/surgery_description.txt @@ -0,0 +1 @@ +Resection of tongue margin, Neck dissection diff --git a/128/surgery_report.txt b/128/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..be191242262371e8ebf410c8c7892eef354bb5ae --- /dev/null +++ b/128/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthetist. Insertion of a covered retractor. Snaring of the tongue and inspection of the edge of the tongue. This reveals a bulging scarred change with 2 suture marks. In consultation with , the R1 resection is in the posterior and lateral part, where a large area is resected. The resected area is thread-marked for the frozen section. The pathologist finds the margins to be free. Then the neck is dissected. Head positioning and sterile washing and draping. Curved skin incision on the anterior edge of the sternocleidomastoid muscle. Release of the sternocleidomastoid muscle in the anterior margin area. Exposure of the external jugular vein and preservation of this vein. Exposure of the omohyoid muscle, then the digaster muscle and the submandibular gland. Insertion of a retractor for below. Locate the accessorius nerve and expose the entire length of the internal jugular vein. Exposure of the cervical sinus. Exposure of the hypoglossal nerve. Clearing of levels IIa and b, then transition to levels III and IV and clearing of level V while sparing all plexus branches. Then visualization of the vagus nerve and the common and external and internal carotid arteries. Clearing of the anterior neck block while sparing the ansa as well as the V. facialis and the A. thyroidea superior. Now removal of level I. There were several enlarged lymph nodes in levels I, IIa and b, III and IV. Macroscopically no enlarged lymph nodes in level V, but to be on the safe side this level was also evacuated. Insertion of a Redon drain. Two-layer wound closure. \ No newline at end of file diff --git a/129/InvasionFront_CD3_block11_x1_y8_patient129_0.json b/129/InvasionFront_CD3_block11_x1_y8_patient129_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba69efa167628e3656f5ac6b3a76c8fc40912c17 --- /dev/null +++ b/129/InvasionFront_CD3_block11_x1_y8_patient129_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 19489.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/129/InvasionFront_CD3_block11_x2_y8_patient129_1.json b/129/InvasionFront_CD3_block11_x2_y8_patient129_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a56631d472821146677996068846b31b6657611d --- /dev/null +++ b/129/InvasionFront_CD3_block11_x2_y8_patient129_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 19414.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/129/InvasionFront_CD8_block11_x1_y8_patient129_0.json b/129/InvasionFront_CD8_block11_x1_y8_patient129_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b1d71b251b65818744d86b08ca98c63023914dc --- /dev/null +++ b/129/InvasionFront_CD8_block11_x1_y8_patient129_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6392.9, + "Centroid Y µm": 30677.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/129/InvasionFront_CD8_block11_x2_y8_patient129_1.json b/129/InvasionFront_CD8_block11_x2_y8_patient129_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2731f85e2b9002048dd129a694de564538d67436 --- /dev/null +++ b/129/InvasionFront_CD8_block11_x2_y8_patient129_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8923.3, + "Centroid Y µm": 30643.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/129/TumorCenter_CD3_block11_x1_y8_patient129_0.json b/129/TumorCenter_CD3_block11_x1_y8_patient129_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d7bc7a0596b0657ed686479080a5a0b5d1dd25bb --- /dev/null +++ b/129/TumorCenter_CD3_block11_x1_y8_patient129_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6802.2, + "Centroid Y µm": 19083.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/129/TumorCenter_CD3_block11_x2_y8_patient129_1.json b/129/TumorCenter_CD3_block11_x2_y8_patient129_1.json new file mode 100644 index 0000000000000000000000000000000000000000..debfa60dfe15e395d3bc388c9d23f841e71cf894 --- /dev/null +++ b/129/TumorCenter_CD3_block11_x2_y8_patient129_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9340.3, + "Centroid Y µm": 19410.1, + "Num Detections": 37, + "Num Negative": 37, + "Num Positive": 0, + "Positive %": 0.0, + "Num Positive per mm^2": 0.0 + } +} \ No newline at end of file diff --git a/129/TumorCenter_CD8_block11_x1_y8_patient129_0.json b/129/TumorCenter_CD8_block11_x1_y8_patient129_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f479951baa50626696b75cda33a71d60112464c --- /dev/null +++ b/129/TumorCenter_CD8_block11_x1_y8_patient129_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3885.7, + "Centroid Y µm": 19933.9, + "Num Detections": 4, + "Num Negative": 4, + "Num Positive": 0, + "Positive %": 0.0, + "Num Positive per mm^2": 0.0 + } +} \ No newline at end of file diff --git a/129/TumorCenter_CD8_block11_x2_y8_patient129_1.json b/129/TumorCenter_CD8_block11_x2_y8_patient129_1.json new file mode 100644 index 0000000000000000000000000000000000000000..852db2b0fe5785815c29ebfdd8eb948fb29aa351 --- /dev/null +++ b/129/TumorCenter_CD8_block11_x2_y8_patient129_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6969.4, + "Centroid Y µm": 19790.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/129/history_text.txt b/129/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/129/icd_codes.txt b/129/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bfd7fe5217f5dd63c29b891964b130c83f60b10a --- /dev/null +++ b/129/icd_codes.txt @@ -0,0 +1 @@ +CUP [Cancer of Unknown Primary][C80.0 ] Halsmetastasen[C77.0 ] \ No newline at end of file diff --git a/129/ops_codes.txt b/129/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3e4d87de2afd97edc1ea76e2e358e5ac351ad856 --- /dev/null +++ b/129/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] Tonsillektomie mit Dissektionstechnik[5-281.0 ] Biopsie an der Zunge ohne Inzision[1-420.1 ] Biopsie am Nasopharynx ohne Inzision[1-422.2 ] \ No newline at end of file diff --git a/129/patient_clinical_data.json b/129/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8597daac81acd605f36cb6d221a554611fcc2173 --- /dev/null +++ b/129/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/129/patient_pathological_data.json b/129/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..013aea3aa80c20c2d1845aa822ca7d04a872d409 --- /dev/null +++ b/129/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "129", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 11.0, + "number_of_resected_lymph_nodes": 12, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/129/surgery_description.txt b/129/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e3dbb453fec6b08a0f6e1f81296d1a0dedf10a99 --- /dev/null +++ b/129/surgery_description.txt @@ -0,0 +1 @@ +CUP panendoscopy with bilateral tonsillectomy, Biopsy of zygomatic groove, Nasopharyngeal curettage, Right neck dissection diff --git a/129/surgery_report.txt b/129/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..054dfd91fe1bd195e26868711e52a0a279f29ba1 --- /dev/null +++ b/129/surgery_report.txt @@ -0,0 +1 @@ +Initially, the operation begins with tracheoscopy: here, the glottic plane can be adjusted by laryngoscopy without any problems. Then inspection of the subglottis and the trachea up to the bifurcation with the O° optics. The mucosal conditions here are normal and inconspicuous. The patient is then intubated by the surgeon. Then oesophagoscopy: problem-free entry into the oesophagus with the flexible instrument. Then visual endoscopy into the stomach. A regular folded relief can be seen here. No evidence of a tumor or other mass. When reflecting back, careful inspection of the esophageal mucosa again, where irritation-free mucosal conditions can also be seen here, without any evidence of tumor growth. The patient is then repositioned and the hypopharynx and larynx are inspected again. Here too, the mucosal conditions were normal and completely unremarkable. The laryngeal skeleton is inconspicuous with non-irritated mucous membranes. The glottic plane is clear. The interary region and postcricoid region also appear completely normal. Then inspection of the oropharynx. Here, too, the mucosal conditions are largely normal and unremarkable. However, the left tonsil is slightly larger than the right and indurated. Other mucosal conditions in the area of the base of the tongue, the vallecula and the oral cavity are unremarkable. Due to the suspicious accumulation in the PET in the area of the tonsil and base of the tongue on the left side, the decision was made to perform a tonsillectomy, which was carried out without any problems. The specimen is then sent for frozen section evaluation. However, this is assessed as tumor-free in the frozen section. The decision was therefore made to perform a tonsillectomy on the right side. This was also carried out without any problems, sparing the anterior and posterior palatal arch, as on the left side. Subsequently, deep biopsies are taken from the area at the base of the tongue in the middle and on both sides. These are also sent separately for histological examination. Careful hemostasis is then performed. After re-inspection of the tonsilloliths with dry wounds, insertion of the velotractio and inspection of the nasopharynx. Here too, the mucosal conditions are normal and inconspicuous. Nevertheless, the nasopharyngeal curettage is performed here while sparing the tubal bulges. The removed tissue is also sent for histological examination. After careful hemostasis, the patient is repositioned for neck dissection on the right side. Injection of local anesthetic with adrenaline in the area of the old scar and along the front edge of the sternocleidomastoid muscle. After disinfection of the surgical field, skin incision along the anterior edge of the sternocleidomastoid muscle, including the old scar. Subsequent layer-by-layer dissection in depth. Exposure of the cervical vascular sheath. In the caudal area this appears completely inconspicuous. Exposure of the omohyoid muscle with exposure of the cervical vascular sheath. Then begin dissection of the caudal neck preparation where several hardened and enlarged lymph nodes can be palpated. These are all removed. Then dissection of the lateral neck preparation in a cranial direction. Several metastases can now be seen in the area of the vein angle, which appear to infiltrate the vein cranial to the vein angle. Now follow the exit of the facial vein proximally and visualize the capsule of the submandibular gland and the digaster muscle. This is then followed further dorsally. Find the hypoglossal nerve here. It can now be seen that there is a pronounced metastatic conglomerate in the area of the accessorius triangle at the transition to the hypoglossal triangle. The sternocleidomastoid muscle and accessorius nerve are deeply infiltrated by the conglomerate in this area. Now consult , who recommends aiming for a radical approach here. Therefore, removal of the sternocleidomastoid muscle and the accessorius nerve. Dissection of the internal jugular vein. Subsequent dissection along the cervical vascular sheath in a cranial direction. In doing so, protect larger branches of the external carotid artery. The hypoglossal nerve as well as the vagus nerve and the border cord can also be spared. Then further dissection on the deep cervical fascia in a cranial direction. Here, several cervical plexus branches are also infiltrated by the conglomerate and must therefore also be resected. ............ Improvement of the overview. Then widen the skin incision retroauricularly. Expose the caudal pole of the parotid gland. Then remove the insertion of the sternocleidomastoid muscle at the tip of the mastoid. Also expose the posterior venter of the digaster muscle. The entire conglomerate can then be dissected cranially along the deep cervical fascia. In the vicinity of the skull base, the conglomerate must then be sharply dissected away from the vagus nerve and hypoglossus. Separate the proximal part of the internal jugular vein directly below the base of the skull. Then remove the entire conglomerate. Macroscopically, the resection appears healthy. Consult again, who recommends that tissue samples be taken from the area of the sharp edges of the hypoglossus and the internal carotid artery before entering the base of the skull and that these be sent for final histological assessment. Then carefully stop the bleeding and complete the neck preparation around the anterior neck preparation, which is passed without any problems while sparing the outlets of the facial vein and superior thyroid. The wound is then carefully rinsed again and the bleeding is stopped once more. After insertion of a Redon drainage, two-layer wound closure. Further procedure depends on the histological results. If a marginal sample in the area of the vagus nerve, hypoglossal nerve or internal carotid artery proves positive, a further revision of the neck dissection should be discussed with the patient. However, this would mean a further radical procedure with removal of the hypoglossal and vagus nerve and, if necessary, closure of the internal carotid artery. If the primary is not found during the CUP panendo, the patient should then undergo radiochemotherapy as soon as possible. \ No newline at end of file diff --git a/130/InvasionFront_CD3_block15_x1_y5_patient130_0.json b/130/InvasionFront_CD3_block15_x1_y5_patient130_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ca849026c4d2eb5545a8cfd38c068c5c71c7326 --- /dev/null +++ b/130/InvasionFront_CD3_block15_x1_y5_patient130_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5722.0, + "Centroid Y µm": 23062.8, + "Num Detections": 16363, + "Num Negative": 16282, + "Num Positive": 81, + "Positive %": 0.495, + "Num Positive per mm^2": 36.03 + } +} \ No newline at end of file diff --git a/130/InvasionFront_CD3_block15_x2_y5_patient130_1.json b/130/InvasionFront_CD3_block15_x2_y5_patient130_1.json new file mode 100644 index 0000000000000000000000000000000000000000..348f717d58098fdc44da292c05eb3e042a5698a9 --- /dev/null +++ b/130/InvasionFront_CD3_block15_x2_y5_patient130_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8370.6, + "Centroid Y µm": 22862.9, + "Num Detections": 17467, + "Num Negative": 17307, + "Num Positive": 160, + "Positive %": 0.916, + "Num Positive per mm^2": 74.16 + } +} \ No newline at end of file diff --git a/130/InvasionFront_CD8_block15_x1_y5_patient130_0.json b/130/InvasionFront_CD8_block15_x1_y5_patient130_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fab09775b197c147b60d3c6f730560bee454e930 --- /dev/null +++ b/130/InvasionFront_CD8_block15_x1_y5_patient130_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.6, + "Centroid Y µm": 12459.6, + "Num Detections": 11143, + "Num Negative": 11033, + "Num Positive": 110, + "Positive %": 0.9872, + "Num Positive per mm^2": 67.64 + } +} \ No newline at end of file diff --git a/130/InvasionFront_CD8_block15_x2_y5_patient130_1.json b/130/InvasionFront_CD8_block15_x2_y5_patient130_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d7eef3053cf06e25d60bafe7c157dbdac254951 --- /dev/null +++ b/130/InvasionFront_CD8_block15_x2_y5_patient130_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6414.4, + "Centroid Y µm": 12350.7, + "Num Detections": 10367, + "Num Negative": 10222, + "Num Positive": 145, + "Positive %": 1.399, + "Num Positive per mm^2": 102.94 + } +} \ No newline at end of file diff --git a/130/TumorCenter_CD3_block15_x1_y5_patient130_0.json b/130/TumorCenter_CD3_block15_x1_y5_patient130_0.json new file mode 100644 index 0000000000000000000000000000000000000000..19a49762ef6b49a4baa9dd03824c36b2adbfc2f8 --- /dev/null +++ b/130/TumorCenter_CD3_block15_x1_y5_patient130_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4072.8, + "Centroid Y µm": 15941.6, + "Num Detections": 13800, + "Num Negative": 12415, + "Num Positive": 1385, + "Positive %": 10.04, + "Num Positive per mm^2": 609.71 + } +} \ No newline at end of file diff --git a/130/TumorCenter_CD3_block15_x2_y5_patient130_1.json b/130/TumorCenter_CD3_block15_x2_y5_patient130_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6ad968ed9764273dbed602c01612222319f2cd36 --- /dev/null +++ b/130/TumorCenter_CD3_block15_x2_y5_patient130_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 15866.6, + "Num Detections": 15830, + "Num Negative": 15788, + "Num Positive": 42, + "Positive %": 0.2653, + "Num Positive per mm^2": 20.13 + } +} \ No newline at end of file diff --git a/130/TumorCenter_CD8_block15_x1_y5_patient130_0.json b/130/TumorCenter_CD8_block15_x1_y5_patient130_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8fa85eb8e3d503a2c18624509943df262f481708 --- /dev/null +++ b/130/TumorCenter_CD8_block15_x1_y5_patient130_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 12593.3, + "Num Detections": 15122, + "Num Negative": 14961, + "Num Positive": 161, + "Positive %": 1.065, + "Num Positive per mm^2": 72.23 + } +} \ No newline at end of file diff --git a/130/TumorCenter_CD8_block15_x2_y5_patient130_1.json b/130/TumorCenter_CD8_block15_x2_y5_patient130_1.json new file mode 100644 index 0000000000000000000000000000000000000000..db2afdf606b23d8f13c448cd57292cbbd4b4bbd7 --- /dev/null +++ b/130/TumorCenter_CD8_block15_x2_y5_patient130_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8920.3, + "Centroid Y µm": 12543.4, + "Num Detections": 15481, + "Num Negative": 15396, + "Num Positive": 85, + "Positive %": 0.5491, + "Num Positive per mm^2": 39.65 + } +} \ No newline at end of file diff --git a/130/history_text.txt b/130/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d76eb5ffa267900891c0dfe087a88245b39e1118 --- /dev/null +++ b/130/history_text.txt @@ -0,0 +1 @@ +Patient with left tongue margin carcinoma, sonographic evidence of lymph node involvement on the left. Therefore indication for the above-mentioned operation. \ No newline at end of file diff --git a/130/icd_codes.txt b/130/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b471b784d2b9d9c09a5a3b27210fcf133740a8a5 --- /dev/null +++ b/130/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 ] \ No newline at end of file diff --git a/130/ops_codes.txt b/130/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ee276da5473fbe731533e8065b46483cb3cc68f3 --- /dev/null +++ b/130/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngotracheobronchoskopie mit starrem Endoskop[1-620.1 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Direkte Hypopharyngoskopie[1-611.0 ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] PEG-Sonde Anlage[5-431.2 ] Zungentumorexzision[5-250.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] \ No newline at end of file diff --git a/130/patient_clinical_data.json b/130/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..24dd18e3a0dcbe1b3a43ae70b0479842b49c3651 --- /dev/null +++ b/130/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2008, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/130/patient_pathological_data.json b/130/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c32f6926eff3630063a675264db0e425005019d1 --- /dev/null +++ b/130/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "130", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/130/surgery_description.txt b/130/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..38417f7f56bef65a370983ea1378dcd089977f0d --- /dev/null +++ b/130/surgery_description.txt @@ -0,0 +1 @@ +Resection of tongue margin carcinoma, Modified radical left neck dissection, PEG placement, Panendoscopy diff --git a/130/surgery_report.txt b/130/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..083ac849d66fd680ff77e25f7b8fb5bd278b9ba8 --- /dev/null +++ b/130/surgery_report.txt @@ -0,0 +1 @@ +Initial tracheoscopy: normal conditions on all sides from the carina to the glottis. Orotracheal intubation by the surgeon. MLE: Endolarynx, epiglottis, arytenoid region and postcricoid region clear. Orohypopharyngoscopy: Unobtrusive mucosal conditions in the entire orohypopharynx up to the esophageal entrance. Tonsil lobe and base of tongue free on palpation. Esophagoscopy and PEG placement (): Advancement of the esophagoscope into the stomach, no abnormalities on gross examination. A 9-gauge stomach wall probe is inserted in the typical manner without complications. The endoscope was then withdrawn, and no tumor was detected in the esophagus. Subsequent inspection of the oral cavity. The approx. 3 x 2 cm large exophytic mass on the left edge of the tongue is seen. This is followed by enoral tumor resection: insertion of the oral retractor. Tonguing of the tongue. Incision of the tumor with a safety margin of 1.5 to 2 cm on all sides. The lingual artery must also be cut off, which is treated with a stitch and ligature. Tongue preparation is thread-marked for frozen section. The preparation is resected in all directions R0. The defect is then completely sutured using 2.0 Vicryl sutures. Subsequent repositioning for modified radical neck dissection on the right: skin incision in front of the sternocleidomastoid muscle. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle and digastric muscle. Exposure of the cervical vascular sheath, internal jugular vein, internal and external carotid artery and vagus nerve. Exposure of the accessorius nerve. Unlocking of the dorsal neck preparation and preservation of the branches of the cervical plexus. Subsequent development of the anterior neck preparation with exposure and preservation of the superior thyroid artery, hypoglossal nerve and facial vein. Subsequent ligation of the lingual artery to prevent bleeding. Then also careful hemostasis. Finally, wound closure in layers and insertion of a Redon drainage. Patient should be fed via PEG for a few days postoperatively. Single shot antibiotics with Unacid were administered intraoperatively. Discuss neck dissection on the other side depending on the histology of the neck preparation. \ No newline at end of file diff --git a/131/InvasionFront_CD3_block7_x5_y10_patient131_0.json b/131/InvasionFront_CD3_block7_x5_y10_patient131_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d2632f56f9514648d73330c78c74433a1a0eabc0 --- /dev/null +++ b/131/InvasionFront_CD3_block7_x5_y10_patient131_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 24212.2, + "Num Detections": 16466, + "Num Negative": 15675, + "Num Positive": 791, + "Positive %": 4.804, + "Num Positive per mm^2": 398.98 + } +} \ No newline at end of file diff --git a/131/InvasionFront_CD3_block7_x6_y10_patient131_1.json b/131/InvasionFront_CD3_block7_x6_y10_patient131_1.json new file mode 100644 index 0000000000000000000000000000000000000000..84f58613d5c916fdac87850e57d98d4cf589ca7a --- /dev/null +++ b/131/InvasionFront_CD3_block7_x6_y10_patient131_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 24187.2, + "Num Detections": 15467, + "Num Negative": 15392, + "Num Positive": 75, + "Positive %": 0.4849, + "Num Positive per mm^2": 42.94 + } +} \ No newline at end of file diff --git a/131/InvasionFront_CD8_block7_x5_y10_patient131_0.json b/131/InvasionFront_CD8_block7_x5_y10_patient131_0.json new file mode 100644 index 0000000000000000000000000000000000000000..84dc5a6da7aa62998eb34fdf1bb37f99548a8b15 --- /dev/null +++ b/131/InvasionFront_CD8_block7_x5_y10_patient131_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 25786.3, + "Num Detections": 18066, + "Num Negative": 16951, + "Num Positive": 1115, + "Positive %": 6.172, + "Num Positive per mm^2": 550.98 + } +} \ No newline at end of file diff --git a/131/InvasionFront_CD8_block7_x6_y10_patient131_1.json b/131/InvasionFront_CD8_block7_x6_y10_patient131_1.json new file mode 100644 index 0000000000000000000000000000000000000000..00b81d1bdcfe8bb43d7abebe06d2fb18d45dfb65 --- /dev/null +++ b/131/InvasionFront_CD8_block7_x6_y10_patient131_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18703.0, + "Centroid Y µm": 26143.4, + "Num Detections": 13175, + "Num Negative": 13038, + "Num Positive": 137, + "Positive %": 1.04, + "Num Positive per mm^2": 84.84 + } +} \ No newline at end of file diff --git a/131/TumorCenter_CD3_block7_x5_y10_patient131_0.json b/131/TumorCenter_CD3_block7_x5_y10_patient131_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0179dd61e3d66ccf27d045c76d350edc990c8505 --- /dev/null +++ b/131/TumorCenter_CD3_block7_x5_y10_patient131_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15816.6, + "Centroid Y µm": 25311.6, + "Num Detections": 26786, + "Num Negative": 19571, + "Num Positive": 7215, + "Positive %": 26.94, + "Num Positive per mm^2": 2766.2 + } +} \ No newline at end of file diff --git a/131/TumorCenter_CD3_block7_x6_y10_patient131_1.json b/131/TumorCenter_CD3_block7_x6_y10_patient131_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6eddf873b79721207a8c0a395e23847839d8c2af --- /dev/null +++ b/131/TumorCenter_CD3_block7_x6_y10_patient131_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 25236.6, + "Num Detections": 21373, + "Num Negative": 16860, + "Num Positive": 4513, + "Positive %": 21.12, + "Num Positive per mm^2": 1950.3 + } +} \ No newline at end of file diff --git a/131/TumorCenter_CD8_block7_x5_y10_patient131_0.json b/131/TumorCenter_CD8_block7_x5_y10_patient131_0.json new file mode 100644 index 0000000000000000000000000000000000000000..59c6b683bf283dc42c3a89a69ee9a03b28640551 --- /dev/null +++ b/131/TumorCenter_CD8_block7_x5_y10_patient131_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15566.8, + "Centroid Y µm": 25011.8, + "Num Detections": 28797, + "Num Negative": 23149, + "Num Positive": 5648, + "Positive %": 19.61, + "Num Positive per mm^2": 2172.3 + } +} \ No newline at end of file diff --git a/131/TumorCenter_CD8_block7_x6_y10_patient131_1.json b/131/TumorCenter_CD8_block7_x6_y10_patient131_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5817ee9640ed43468666f601e7ae6f9ba2406b6a --- /dev/null +++ b/131/TumorCenter_CD8_block7_x6_y10_patient131_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 24936.8, + "Num Detections": 23053, + "Num Negative": 19704, + "Num Positive": 3349, + "Positive %": 14.53, + "Num Positive per mm^2": 1416.5 + } +} \ No newline at end of file diff --git a/131/history_text.txt b/131/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..89f3606fefc3b1ae52c3882d2843991ba349b7d8 --- /dev/null +++ b/131/history_text.txt @@ -0,0 +1 @@ +An extensive cervical metastasis on the right side of the patient's neck was histologically confirmed as squamous cell carcinoma. A panendoscopy performed <2014> showed no evidence of primarius. CT also showed no reliable evidence of primarius with extensive, growing metastasis. Sonographically also conspicuous left cervical lymph nodes. \ No newline at end of file diff --git a/131/icd_codes.txt b/131/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/131/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/131/ops_codes.txt b/131/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5d658048f05b27886e3a7afbf8c4d880a72498ca --- /dev/null +++ b/131/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx durch Pharyngotomie mit Rekonstruktion mit lokaler Schleimhaut[5-295.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 R] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 L] Permanente Tracheotomie[5-312.0 ] Entnahme eines gestielten Fernlappens an der Brustwand[5-904.2a ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Probeexzision am Hypopharynx[1-547 ] \ No newline at end of file diff --git a/131/patient_clinical_data.json b/131/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9dcf755a75ffd5bafb26d80e04b412ab87d2c6ad --- /dev/null +++ b/131/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/131/patient_pathological_data.json b/131/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b555d13b85f882cacc606febbf61e8a418ff7327 --- /dev/null +++ b/131/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "131", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/131/surgery_description.txt b/131/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..72869f9f93d524dfa5fff49ef49b98a8a94c3f4b --- /dev/null +++ b/131/surgery_description.txt @@ -0,0 +1 @@ +Pharyngeal partial resection, Neck dissection, Pedicled flap (Pectoralis major), Tracheotomy diff --git a/131/surgery_report.txt b/131/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..603e759064dcdc88b9b31ee4728d97313ab49107 --- /dev/null +++ b/131/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesia colleagues, another pharyngoscopy/laryngoscopy is performed to search for the primary ear. After inspection of the inconspicuous oral vestibule, the small bore tube is inserted under dental protection. Inspection and palpation of the oral cavity, which is also unremarkable. Now inspection of the oropharynx. This is inconspicuous, especially in the area of the tonsil regions and the base of the tongue. Adjustment of the endolarynx and the subglottic region. No evidence of primarius here either. With an inconspicuous esophageal entrance and left piriform sinus, a circumscribed, centrally ulcerated lesion measuring approx. 1 to 1.5 cm with a raised marginal wall is found in the area of the medial wall of the right piriform sinus. A representative sample is taken and a frozen section is made. This shows a basaloid, poorly differentiated squamous cell carcinoma, thus confirming the primary. Due to the extensive metastasis extending close to the pharyngeal wall, primary transcervical resection is indicated. The PEG tube is then inserted. This is done with the gastroscope under laryngoscopic control. Easy to see through to the stomach. Here, with excellent diaphanoscopy, problem-free puncture of the stomach. The PEG tube is then inserted using the usual thread pull-through method. The patient is then positioned. First turn to the neck dissection on the right side. Here the lymph node metastasis has grown extensively into the skin and is partially open. Incision around the skin area with a safety margin. Separation of the skin and extension of the skin incision cranially and caudally. Separation of the sternocleidomastoid muscle in the case of extensive infiltration. Exposure of the internal jugular vein and removal. In the case of clear cranial infiltration, expose and secure the common carotid artery and vagus nerve. Later resection of the omohyoid muscle. Cranial dissection of the metastasis with subtotal involvement of the cervical plexus roots. Inclusion of paravertebral musculature. Resection on all sides in .............. Infiltration of the submandibular gland, which is also resected. Here also clear infiltration and subsequent resection of the ramus marginalis mandibulae. Detachment of the metastasis on the mandible, taking the periosteum with it, no infiltration here. The accessor nerve is no longer visible in the case of extensive infiltration. Infiltration of the soft tissue up to the paralaryngeal area. Clear infiltration of the hypoglossal nerve, cranial also infiltration of the lingual nerve, but here no enoral growth. Careful dissection in the area of the carotid bulb, here the external carotid artery can be seen walled in by tumor tissue shortly after the exit. Skeletonization of the external carotid artery. Tumor tissue is clearly visible on the vessel, so here it is removed as far as possible at the bulb, here taking a marginal sample, but without the possibility of further resection. Careful free dissection and protection of the internal carotid artery, which is in contact with the tumor over a long distance, here also no further possibility for resection, but also no reliable indication of tumor invasion, therefore RX situation at this point. Cranial dissection, separation of the internal jugular vein cranially. Separation of the digastric muscle during infiltration and resection of the metastasis macroscopically in toto. If there is close contact with the cranial part of the skin, a resection is performed here, otherwise in sano conditions on all sides in the area of the skin. The resectate is sent for definitive histology. Later clearing of the transition from level I b to level I a, here further macroscopically clearly conspicuous nodules. The focus is now turned to the primary tumor region. Circumscribed skeletonization of the laryngeal skeleton. Entering the lateral pharyngeal wall, widening, exposing the piriform sinus. Release of the piriform sinus. Now a good overview of the tumor tissue. Cut around with a safety margin. Defect of the medial piriform sinus wall measuring approx. 2 x 2 cm in total. Resection defect up to the anterior piriform sinus wall, otherwise intact mucosa on all sides. The resectate is sent in thread-marked for frozen section diagnostics and appears R0-resected on the specimen. If the mucosa is sufficient and healthy, the primary closure of the pharyngotomy is performed, followed by relining with muscle tissue. Now neck dissection on the left. To do this, make a skin incision on the anterior edge of the sternocleidomastoid muscle. Cut through skin and subcutaneous tissue. Dissection of the platysma. Exposure of the sternocleidomastoid muscle, omohyoid muscle. Release of the submandibular gland with removal of the caudal capsule. Exposure of the digastric muscle. Removal of the anterior neck preparation with careful protection of the facial vein, the cervical vein, the superior thyroid artery and the hypoglossal nerve. Free preparation of the internal jugular vein. Overall, macroscopically conspicuous nodules on the vein. Exposure of the accessor nerve. Protection of the nerve and clearing of the accessorius triangle. Clearing of level V up to the transition to V b with careful protection of the cervical plexus branches, here some enlarged nodes, but not necessarily suspicious macroscopically. Finally, careful wound inspection and, in dry wound conditions, after wound irrigation with Ringer's solution, insertion of a 10-gauge Redon drain and careful, two-layer wound closure. Subsequently turn to tracheotomy, due to the extended radical neck dissection of the right side and potentially considerable risk of swelling due to the extent of the lymph node dissection. Horizontal skin incision below the cricoid cartilage. Exposure and transection of the infrahyoid muscles and exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Insertion between the 2nd and 3rd tracheal ring and subsequent insertion of the tracheostoma in the usual manner. Subsequent easy transfer to a size 8 low-cuff cannula, which is suture-fixed. At the same time, a pectoralis major flap was elevated from the right. After measuring the cutaneous defect in the area of the right neck skin, a 9 x 5 cm area of skin was lifted. Paramammary, broad-based lifting with subtotal lifting of the pectoralis major muscle. Careful subfascial release of the muscle. Exposure of the pectoralis minor muscle. Identification of the pedicle vessel and, while protecting the pedicle vessel, elevation of the flap, cranial tunneling and tension-free insertion into the neck defect, relining of the pharynx, the pharyngeal suture and adequate coverage of the neck skin afterwards. Insertion of 10 Redon drains and careful, strong, multi-layered wound closure. Subsequent completion of the procedure without any indication of complications. Conclusion: Intraoperatively confirmed and R0-resected cT1 hypopharyngeal carcinoma in the area of the medial piriform sinus wall on the right as primary in cN3 neck status right, here extended radical neck dissection with resection of the external carotid artery, the hypoglossal nerve, the ramus marginalis mandibulae, the lingual nerve and the border cord. Due to the long-distance contact with no possibility of resection in the area of the internal carotid artery, an RX situation can be assumed in the cervical area, which is why adjuvant therapy should be escalated here. Postoperatively, please perform an X-ray gruel swallow on the 10th day, followed by decannulation depending on the current prognostically unclear swallowing function. \ No newline at end of file diff --git a/132/InvasionFront_CD3_block20_x3_y2_patient132_0.json b/132/InvasionFront_CD3_block20_x3_y2_patient132_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be63692af4e50f77945a387446b7859eae5cb675 --- /dev/null +++ b/132/InvasionFront_CD3_block20_x3_y2_patient132_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13193.0, + "Centroid Y µm": 5047.3, + "Num Detections": 19080, + "Num Negative": 18740, + "Num Positive": 340, + "Positive %": 1.782, + "Num Positive per mm^2": 145.36 + } +} \ No newline at end of file diff --git a/132/InvasionFront_CD3_block20_x4_y2_patient132_1.json b/132/InvasionFront_CD3_block20_x4_y2_patient132_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c71c995b97d06d53e78e64a613182b05c19ac489 --- /dev/null +++ b/132/InvasionFront_CD3_block20_x4_y2_patient132_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15566.8, + "Centroid Y µm": 5122.3, + "Num Detections": 20033, + "Num Negative": 19613, + "Num Positive": 420, + "Positive %": 2.097, + "Num Positive per mm^2": 188.55 + } +} \ No newline at end of file diff --git a/132/InvasionFront_CD8_block20_x3_y2_patient132_0.json b/132/InvasionFront_CD8_block20_x3_y2_patient132_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b3c982dc85c377ec1d3e1770df99bb4e7bcc7e6f --- /dev/null +++ b/132/InvasionFront_CD8_block20_x3_y2_patient132_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11404.4, + "Centroid Y µm": 5157.8, + "Num Detections": 18271, + "Num Negative": 17849, + "Num Positive": 422, + "Positive %": 2.31, + "Num Positive per mm^2": 184.62 + } +} \ No newline at end of file diff --git a/132/InvasionFront_CD8_block20_x4_y2_patient132_1.json b/132/InvasionFront_CD8_block20_x4_y2_patient132_1.json new file mode 100644 index 0000000000000000000000000000000000000000..52abcf12644d385f62597d0e5e7bd73be1564201 --- /dev/null +++ b/132/InvasionFront_CD8_block20_x4_y2_patient132_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13703.1, + "Centroid Y µm": 4986.0, + "Num Detections": 19911, + "Num Negative": 19417, + "Num Positive": 494, + "Positive %": 2.481, + "Num Positive per mm^2": 220.15 + } +} \ No newline at end of file diff --git a/132/TumorCenter_CD3_block20_x3_y2_patient132_0.json b/132/TumorCenter_CD3_block20_x3_y2_patient132_0.json new file mode 100644 index 0000000000000000000000000000000000000000..54a23c45c5f6f89a9329d4101d1152b532b2ed64 --- /dev/null +++ b/132/TumorCenter_CD3_block20_x3_y2_patient132_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11495.0, + "Centroid Y µm": 4749.5, + "Num Detections": 14932, + "Num Negative": 14339, + "Num Positive": 593, + "Positive %": 3.971, + "Num Positive per mm^2": 304.99 + } +} \ No newline at end of file diff --git a/132/TumorCenter_CD3_block20_x4_y2_patient132_1.json b/132/TumorCenter_CD3_block20_x4_y2_patient132_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b9385d152ed0fcef3d4db337b0dfd14a9c3b6a51 --- /dev/null +++ b/132/TumorCenter_CD3_block20_x4_y2_patient132_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14005.8, + "Centroid Y µm": 4596.1, + "Num Detections": 15225, + "Num Negative": 14749, + "Num Positive": 476, + "Positive %": 3.126, + "Num Positive per mm^2": 244.6 + } +} \ No newline at end of file diff --git a/132/TumorCenter_CD8_block20_x3_y2_patient132_0.json b/132/TumorCenter_CD8_block20_x3_y2_patient132_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1057cf5ccf443bbf7750b70e7e87ac51f2edcf95 --- /dev/null +++ b/132/TumorCenter_CD8_block20_x3_y2_patient132_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10419.5, + "Centroid Y µm": 5122.3, + "Num Detections": 19495, + "Num Negative": 17736, + "Num Positive": 1759, + "Positive %": 9.023, + "Num Positive per mm^2": 776.59 + } +} \ No newline at end of file diff --git a/132/TumorCenter_CD8_block20_x4_y2_patient132_1.json b/132/TumorCenter_CD8_block20_x4_y2_patient132_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ddf9b2cad9271f25a80cf8b24a5e7457c7ffa7d5 --- /dev/null +++ b/132/TumorCenter_CD8_block20_x4_y2_patient132_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12918.2, + "Centroid Y µm": 4972.4, + "Num Detections": 17591, + "Num Negative": 15941, + "Num Positive": 1650, + "Positive %": 9.38, + "Num Positive per mm^2": 753.96 + } +} \ No newline at end of file diff --git a/132/history_text.txt b/132/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/132/icd_codes.txt b/132/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..807c5d4aceb36940cfb7343befc0ba5eade4361c --- /dev/null +++ b/132/icd_codes.txt @@ -0,0 +1 @@ +Larynxkarzinom[C32.9 ] Lymphknotenmetastasen onA[C77.9 B] \ No newline at end of file diff --git a/132/ops_codes.txt b/132/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a336d34197a1952a1e90a979c3a2c7addaf0ebcd --- /dev/null +++ b/132/ops_codes.txt @@ -0,0 +1 @@ +Sonstige einfache Laryngektomie[5-303.0x ] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] Selektive Neck dissection in 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/132/patient_clinical_data.json b/132/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ad193223e98d96d645c807da5e35e1f803bbe257 --- /dev/null +++ b/132/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/132/patient_pathological_data.json b/132/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..34b8f78312bda7a7d86478a34c2d40473f305efb --- /dev/null +++ b/132/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "132", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 28, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/132/surgery_description.txt b/132/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ba01ac190c0e834f0aad42f556a2ec18d181afa9 --- /dev/null +++ b/132/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, PEG placement diff --git a/132/surgery_report.txt b/132/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..88447de4d2a4ec3ebc76bccac814f80dac7aafac --- /dev/null +++ b/132/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Entry with the flexible esophagoscope and inspection of the esophagus and stomach. No abnormalities here. With good diaphanoscopy, insertion of a PEG tube using the thread pull-through method. This is successful without any problems. Enter with the Kleinsasser tube and inspect the hypopharynx and larynx. The epiglottis on the right side shows an exophytic mass that affects both the lingual and laryngeal epiglottis and also crosses the midline. The exophytic mass extends over the aryepiglottic fold onto the arytenoid cartilage on the right side and upwards onto the vallecula. The sinus morgagni, the right pocket fold and the right vocal fold are also affected. Inspection of the hypopharynx. There are no abnormalities here. The hypopharyngeal side walls as well as the piriform sinus and the esophageal opening are clear. CT morphology revealed a thyroid cartilage destruction. Placement of a nasogastric tube and sterile washing and draping. Application of an apron flap in the usual manner. Start of swept head isulation on the right side and start of neck dissection on the right. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland. Exposure of the nervus accessorius, the internal jugular vein, the vagus nerve and the external and internal carotid arteries. Detachment of the cervical vascular sheath from the larynx. Ligation of the laryngeal artery and laryngeal vein. Transection of the superior laryngeal nerve. Isolation of the hyoid bone. Detachment of the hyoid bone from the muscles at the base of the tongue. Detachment of the infrahyoid musculature. A lot of tissue is left on the larynx due to the infiltration of the thyroid cartilage. Turning to the opposite side. Similar procedure. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland, accessorius nerve, cervical vascular sheath. Free preparation of the internal jugular vein. Detachment of the cervical vascular sheath from the larynx. Dissection of the laryngeal bundle. Detachment of the thyroid gland on both sides. Positioning for performing the tracheotomy. Insertion between the second and third tracheal cartilages. Creation of a mucocutaneous anastomosis in the anterior region. Re-intubation. Detachment of the hyoid bone from the base of the tongue on the left side and detachment of the infrahyoid muscles. Then detachment of the piriform sinus on the left side from the thyroid cartilage. This is successful without any problems. Turn to the right side. Here too, release the piriform sinus from the thyroid cartilage. Proceed very carefully here so that you do not get into the tumor. Perform the pharyngotomy from the left side. Disluxation of the epiglottis and incision of the mucosa along the edge of the epiglottis, initially on the left side up to the aryepiglottic fold and the arytenoid cartilage. Detachment of the larynx from the piriform sinus. Turning to the other side. Here, too, first proceed along the edge of the epiglottis to save mucosa. Then some of the pharynx must also be resected as it is permeated with tumor. Safety distance 1.5 cm to 2 cm. Detachment of the larynx below the cricoid cartilage. In the area of the base of the tongue on the left side, the resection appears to be relatively close, so a piece is resected here again and a final margin sample is taken. Marginal sample taken from the right pharyngeal mucosa and at the esophageal entrance. Pathology found no carcinoma cells or carcinoma in situ in any of the marginal samples. Therefore intraoperative R0 situation. Neck dissection is now completed on both sides with removal of the neck specimen from level II a to V a while sparing the plexus branches. Insertion of a voice valve prosthesis in the usual manner. This is successful without any problems. The pharyngeal suture is performed in two layers using single button sutures. A T-shaped suture is created at the base of the tongue and the infrahyoid muscles and some of the pharyngeal muscles are sutured over at the end. However, this is done very carefully so as not to constrict the pharynx. Before the pharyngeal suture, an esophagotomy was performed in the area of the upper esophageal sphincter. Incision of the base of the sternocleidomastoid muscle to achieve a flat tracheostoma. Placement of two Redon drains. Folding back the apron flap. Incision of the apron flap into the tracheostoma. Two-layer wound closure and insertion of a tracheostomy tube. The patient goes to the intensive care unit. Please no oral food for 10 days, then X-ray broad swallow and, if there is no fistula, food build-up in the usual way. After receiving the histology, the patient is presented to the tumor conference to plan adjuvant therapy. \ No newline at end of file diff --git a/133/InvasionFront_CD3_block14_x5_y12_patient133_0.json b/133/InvasionFront_CD3_block14_x5_y12_patient133_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d0addb3f4a7a9a1882dbc888ec820ace66c8abd0 --- /dev/null +++ b/133/InvasionFront_CD3_block14_x5_y12_patient133_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 34181.9, + "Num Detections": 9851, + "Num Negative": 9814, + "Num Positive": 37, + "Positive %": 0.3756, + "Num Positive per mm^2": 32.0 + } +} \ No newline at end of file diff --git a/133/InvasionFront_CD3_block14_x6_y12_patient133_1.json b/133/InvasionFront_CD3_block14_x6_y12_patient133_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0c0a53665b24fb8ace7cd00775a15a514480fd21 --- /dev/null +++ b/133/InvasionFront_CD3_block14_x6_y12_patient133_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 34356.8, + "Num Detections": 18883, + "Num Negative": 18752, + "Num Positive": 131, + "Positive %": 0.6937, + "Num Positive per mm^2": 61.33 + } +} \ No newline at end of file diff --git a/133/InvasionFront_CD8_block14_x5_y12_patient133_0.json b/133/InvasionFront_CD8_block14_x5_y12_patient133_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ef440a9f55da65964afbaed4bc0518c5ded0120f --- /dev/null +++ b/133/InvasionFront_CD8_block14_x5_y12_patient133_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 29459.4, + "Num Detections": 22226, + "Num Negative": 22081, + "Num Positive": 145, + "Positive %": 0.6524, + "Num Positive per mm^2": 57.1 + } +} \ No newline at end of file diff --git a/133/InvasionFront_CD8_block14_x6_y12_patient133_1.json b/133/InvasionFront_CD8_block14_x6_y12_patient133_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5bd8b5f0fc1ec335d33f2f391cf99487952708e7 --- /dev/null +++ b/133/InvasionFront_CD8_block14_x6_y12_patient133_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 29534.4, + "Num Detections": 21953, + "Num Negative": 21816, + "Num Positive": 137, + "Positive %": 0.6241, + "Num Positive per mm^2": 56.53 + } +} \ No newline at end of file diff --git a/133/TumorCenter_CD8_block14_x5_y12_patient133_0.json b/133/TumorCenter_CD8_block14_x5_y12_patient133_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a74522c4c55612293a5f69d29ee7bbed470d4646 --- /dev/null +++ b/133/TumorCenter_CD8_block14_x5_y12_patient133_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15416.8, + "Centroid Y µm": 30583.8, + "Num Detections": 25315, + "Num Negative": 24745, + "Num Positive": 570, + "Positive %": 2.252, + "Num Positive per mm^2": 205.86 + } +} \ No newline at end of file diff --git a/133/TumorCenter_CD8_block14_x6_y12_patient133_1.json b/133/TumorCenter_CD8_block14_x6_y12_patient133_1.json new file mode 100644 index 0000000000000000000000000000000000000000..67401bda8032c884fffb277d600867ce55884329 --- /dev/null +++ b/133/TumorCenter_CD8_block14_x6_y12_patient133_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17940.5, + "Centroid Y µm": 30583.8, + "Num Detections": 22958, + "Num Negative": 21730, + "Num Positive": 1228, + "Positive %": 5.349, + "Num Positive per mm^2": 460.43 + } +} \ No newline at end of file diff --git a/133/history_text.txt b/133/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..210b3af4a0928a832dbfccd4a6a3916dda0e7d73 --- /dev/null +++ b/133/history_text.txt @@ -0,0 +1 @@ +The patient's anterior right floor of mouth carcinoma <2015>, which had already been confirmed externally, was confirmed during a panendoscopy. Overall, after completion of the diagnostics, cT2 cN2b cM tongue margin carcinoma on the right in the area of the underside of the tongue or the anterior floor of the mouth on the right. In our interdisciplinary tumor conference, the primary surgical procedure was recommended. \ No newline at end of file diff --git a/133/icd_codes.txt b/133/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a8561749661f6fa1d157ae742c87985409c000a --- /dev/null +++ b/133/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] Neubildung bösartig Mundboden sonstige[C04.8 R] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/133/ops_codes.txt b/133/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2b3f4c18538d032648055d2d483d25b0a58ccbdd --- /dev/null +++ b/133/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Glossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.02 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.48 R] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 B] Permanente Tracheotomie[5-312.0 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Primärnaht an der Haut des Oberschenkels[5-900.0e R] Entnahme eines freien Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-904.0e R] \ No newline at end of file diff --git a/133/patient_clinical_data.json b/133/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4fecec5bb30733a8469287cfa5e44679cb063c9f --- /dev/null +++ b/133/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 63, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/133/patient_pathological_data.json b/133/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f08b7b56bdde0197c1bb59f1add436f8f7328440 --- /dev/null +++ b/133/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "133", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 32, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/133/surgery_description.txt b/133/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4fc8a305b6cb908a6d7661ad250c647dfb0d0617 --- /dev/null +++ b/133/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Partial glossectomy, Neck dissection, Tracheotomy, Defect coverage diff --git a/133/surgery_report.txt b/133/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0804fa5615082bce916ef27f69119816fb8e717d --- /dev/null +++ b/133/surgery_report.txt @@ -0,0 +1 @@ +First inspection of the primary tumor region after transnasal intubation and preparation by the anesthesia colleagues. Positioning of the patient. The ulcerated tumor described above is seen in the area of the underside of the tongue and the anterior floor of the mouth on the right side with a largely endophytic tumor component and complete fixation of the underside of the tongue on the right side corresponding to the preoperative clinic. No infiltration of the alveolar ridge. No infiltration of the left-sided floor of the mouth. The tumor is now cut around with a safety margin of a good 1 cm in the area of the anterior alveolar ridge. Here, the mucosa is pushed away from the bone, otherwise wide in sano resection in the area of the tongue, growth towards the outer muscles of the floor of the mouth, but these are not infiltrated. Exposure of the muscles of the floor of the mouth, no direct contact with the metastasis in level I on the right side. Macroscopic and palpatory in sano resection of the tumor, which is thread-marked for frozen section diagnostics and is resected in sano on the specimen. Scarce area basally towards the tip of the tongue with otherwise clearly in sano resection. For this reason, a resection is performed here to extend the safety margin, which is then used for definitive histology so that a safe in sano resection is finally available. Measurement of the defect. Turn first to the neck dissection and tracheotomy. Start with the right side. Submandibular incision. Cut through the skin and subcutaneous tissue. Separation and dissection of the platysma. Exposure of the sternocleidomastoid muscle and the omohyoid muscle. Release of the submandibular gland and exposure of the digastric muscle. This reveals a moderately displaceable, high-suspecting mass located in front of the submandibular gland, which lies against the mandible but still shows some displacement here. Exposure and dissection of the facial vein, which drains into the anterior jugular vein and the internal jugular vein. Excision of the submandibular gland, including level Ib, here some small but coarse and therefore conspicuous nodules. For resection of the metastasis, incision on the mandible on the periosteum. Push off the periosteum. However, the metastasis can be detached here. Deposition of the anterior venter of the digastric muscle if there is clear infiltration. Also circumscribed infiltration of the anterior floor of the mouth. Therefore clear perinodal spread here. En bloc entrainment, here from level Ia. Hypoglossal nerve, lingual nerve, lingual artery and facial artery can be preserved. Now free preparation of the internal jugular vein after exposure of the accessorius nerve. Dissection of the accessorius triangle and dissection of level V while carefully preserving the cervical plexus branches and exposing the common carotid artery and vagus nerve. Dissection of the internal jugular vein reveals a highly visible mass on the common carotid artery extending anteriorly into the jugulofacial angle. Careful dissection of the vein. There is a circumscribed infiltration of the mouth of the facial vein. This is therefore removed. The vessel to the anterior jugular vein is also removed. Complete and expose the internal jugular vein while maintaining cranial continuity and completing the neck dissection. The tunnel is created enorally. Create a tunnel measuring approx. 3 QF for stem positioning. Approach the neck dissection on the left side. Here also submandibular incision, cutting through skin and subcutaneous tissue, exposing and cutting through the platysma. Dissection of the platysma. Exposure of the sternocleidomastoid muscle and preservation of the external jugular vein and on the opposite side. Exposure of the omohyoid muscle. Release of the submandibular gland, taking the capsule with it. Exposure of the digastric muscle. Free preparation and preservation of the facial vein. Exposure of the accessorius nerve. Dissection of the internal jugular vein. Removal of the anterior neck preparation with careful exposure and protection of the cervical artery of the superior thyroid and the hypoglossal nerve and preservation of the facial nerve draining into the internal jugular vein. Exposure of the accessorius nerve. Complete according to level V, exploration of the sonographically described mass in level Vb. An oval, but rough and therefore suspicious mass measuring approx. 1 cm is actually found here. This is extirpated and level Vb is completed. Careful treatment of some leaking lymphatic fluid. Finally, absolutely dry conditions. Even after multiple inspections, the wound is finally irrigated, followed by insertion of a 10-gauge Redon drain and careful two-layer wound closure. The tracheotomy is then performed in the case of post-thyroidectomy. Horizontal incision below the cricoid cartilage. Cut through skin and subcutaneous tissue. Exposure and transection of the infrahyoid musculature. Exposure of the cricoid cartilage and the anterior surface of the trachea. Insertion between the 2nd and 3rd tracheal ring, forming a horizontal visor tracheotomy. Subsequent suturing of the mucocutaneous anastomosis, later problem-free reintubation on a low cuff cannula, which is suture-fixed. The defect is then measured. After tumor resection, this resulted in resection of the anterior third or anterior half of the right-sided tongue and resection of the anterior floor of the mouth. Due to the slender proportions, the decision was made to elevate and cover the defect with an anterolateral transfemoral graft. After doppler sonographic identification of the main perforator and marking of the anatomical landmarks, doppler sonographic identification of 2 secondary perforators, marking of the graft measuring a total of 6 x 8 cm with a special mouth floor configuration. Subsequent medial incision, cutting of skin and subcutaneous tissue. Exposure and securing of the rectus femoris muscle. Subcutaneous release while protecting the vascularized intermuscular septum. Performing a release incision after identifying the pedicle vessels. An oblique branch running steeply caudally and a further upper oblique branch can be seen. Identification of the main perforator with musculocutaneous course. Dissection of the main perforator. Initially, it can be seen that one of the secondary perforators extends from the main perforator; later, during dissection, the second secondary perforator can also be seen extending from the main perforator. After tracing the perforator, it can be seen to extend from the oblique upper vessel, leaving a small muscle cuff at the outlet of the perforator. Complete cutting of the graft after preparation of the vascular pedicle. Conditioning of the pedicle vessels and removal of the vital graft. Careful hemostasis in the area of the leg. Subsequent insertion of a 10-gauge Redon drain and careful two-layer wound closure with resection of excess skin. The graft is then incorporated transorally. This succeeds well and with sufficient volume filling in the area of the tip of the tongue and the missing lateral tongue. Positioning of the pedicle vessels, conditioning of the superior thyroid artery. Performing the arterial anastomosis with 8.0 Ethilon. Subsequent conditioning of the graft vein. Performing a venous anastomosis with the Coupler system on the superior thyroid vein in the correct pedicle position and graft perfusion. Subsequently, regular graft perfusion and positive spreading phenomenon and regular pedicle pulsation, so that subsequent careful wound closure on the right cervical side, subsequent termination of the procedure without any indication of complications. Note: Due to the patient's documented refusal of a PEG tube, a nasogastric feeding tube was inserted. The patient received intraoperative intravenous antibiotics with clindamycin, which should be continued for 24 hours postoperatively. Conclusion: Intraoperative R0 resected cT2 oral floor carcinoma on the right side with a strikingly aggressive and discontinuous metastatic pattern. Intraoperative cN2c neck status possible, therefore prompt adjuvant therapy should be initiated here. If the graft heals properly, swallowing diagnostics can be started from the 7th to 8th postoperative day. The insertion of a PEG tube during the interval appears to be necessary. \ No newline at end of file diff --git a/134/InvasionFront_CD3_block7_x3_y1_patient134_0.json b/134/InvasionFront_CD3_block7_x3_y1_patient134_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d4df5d6417a7c0f8104e0eca7a8c1264040d3427 --- /dev/null +++ b/134/InvasionFront_CD3_block7_x3_y1_patient134_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11757.9, + "Centroid Y µm": 2232.4, + "Num Detections": 15402, + "Num Negative": 13213, + "Num Positive": 2189, + "Positive %": 14.21, + "Num Positive per mm^2": 1289.1 + } +} \ No newline at end of file diff --git a/134/InvasionFront_CD3_block7_x4_y1_patient134_1.json b/134/InvasionFront_CD3_block7_x4_y1_patient134_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d8a04ffdc4542aeae25a9c100bd89e4b0091a15 --- /dev/null +++ b/134/InvasionFront_CD3_block7_x4_y1_patient134_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14367.4, + "Centroid Y µm": 2223.8, + "Num Detections": 24407, + "Num Negative": 20640, + "Num Positive": 3767, + "Positive %": 15.43, + "Num Positive per mm^2": 1513.7 + } +} \ No newline at end of file diff --git a/134/InvasionFront_CD8_block7_x3_y1_patient134_0.json b/134/InvasionFront_CD8_block7_x3_y1_patient134_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0aa075f110e7de758b7155caa5a29ba36371f98 --- /dev/null +++ b/134/InvasionFront_CD8_block7_x3_y1_patient134_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 3048.4, + "Num Detections": 14420, + "Num Negative": 13914, + "Num Positive": 506, + "Positive %": 3.509, + "Num Positive per mm^2": 335.67 + } +} \ No newline at end of file diff --git a/134/InvasionFront_CD8_block7_x4_y1_patient134_1.json b/134/InvasionFront_CD8_block7_x4_y1_patient134_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e73627018346797d168cfd6a4b60da98d08ee71 --- /dev/null +++ b/134/InvasionFront_CD8_block7_x4_y1_patient134_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16566.2, + "Centroid Y µm": 3298.3, + "Num Detections": 25223, + "Num Negative": 23257, + "Num Positive": 1966, + "Positive %": 7.794, + "Num Positive per mm^2": 834.16 + } +} \ No newline at end of file diff --git a/134/TumorCenter_CD3_block7_x3_y1_patient134_0.json b/134/TumorCenter_CD3_block7_x3_y1_patient134_0.json new file mode 100644 index 0000000000000000000000000000000000000000..56274dee86b10e97d30a661e77eb2f20e9dff243 --- /dev/null +++ b/134/TumorCenter_CD3_block7_x3_y1_patient134_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 2823.5, + "Num Detections": 22725, + "Num Negative": 17386, + "Num Positive": 5339, + "Positive %": 23.49, + "Num Positive per mm^2": 2271.7 + } +} \ No newline at end of file diff --git a/134/TumorCenter_CD3_block7_x4_y1_patient134_1.json b/134/TumorCenter_CD3_block7_x4_y1_patient134_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9198a540767b190628288517d978e83b4e325ae6 --- /dev/null +++ b/134/TumorCenter_CD3_block7_x4_y1_patient134_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 2898.5, + "Num Detections": 22419, + "Num Negative": 15030, + "Num Positive": 7389, + "Positive %": 32.96, + "Num Positive per mm^2": 3055.6 + } +} \ No newline at end of file diff --git a/134/TumorCenter_CD8_block7_x3_y1_patient134_0.json b/134/TumorCenter_CD8_block7_x3_y1_patient134_0.json new file mode 100644 index 0000000000000000000000000000000000000000..017069b26869c7390de0618e8fc054cd1e0141ea --- /dev/null +++ b/134/TumorCenter_CD8_block7_x3_y1_patient134_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 3123.3, + "Num Detections": 23005, + "Num Negative": 21233, + "Num Positive": 1772, + "Positive %": 7.703, + "Num Positive per mm^2": 849.31 + } +} \ No newline at end of file diff --git a/134/TumorCenter_CD8_block7_x4_y1_patient134_1.json b/134/TumorCenter_CD8_block7_x4_y1_patient134_1.json new file mode 100644 index 0000000000000000000000000000000000000000..551f7faad61f2faf1236eb198caa92a77c349af2 --- /dev/null +++ b/134/TumorCenter_CD8_block7_x4_y1_patient134_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 3123.3, + "Num Detections": 27604, + "Num Negative": 25939, + "Num Positive": 1665, + "Positive %": 6.032, + "Num Positive per mm^2": 704.77 + } +} \ No newline at end of file diff --git a/134/history_text.txt b/134/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d7291c9846b171b618b24c5863f6ee4ab641b29d --- /dev/null +++ b/134/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Histological confirmation of a squamous cell carcinoma with enlarged cervical lymph node on the left. As part of the diagnostic imaging, urgent suspicion of oropharyngeal carcinoma in the area of the left tonsil with neck metastasis. \ No newline at end of file diff --git a/134/icd_codes.txt b/134/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bd161309d1fd5fb62acf66ffdeebb47fddc29964 --- /dev/null +++ b/134/icd_codes.txt @@ -0,0 +1 @@ +Tonsillenkarzinom[C09.9 ] Halslymphknotenmetastasen[C77.0 ] \ No newline at end of file diff --git a/134/ops_codes.txt b/134/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0c4b134942f89cdd0dd5857a1c2da6a2353736f --- /dev/null +++ b/134/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Transorale Tumortonsillektomie[5-281.2 ] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] \ No newline at end of file diff --git a/134/patient_clinical_data.json b/134/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b8750ef1d5ce0797b8b4e7ea5a3f4b27e3f14c55 --- /dev/null +++ b/134/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/134/patient_pathological_data.json b/134/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c0253415cbb826f92793ccc884d62af4de8e91af --- /dev/null +++ b/134/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "134", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 23, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/134/surgery_description.txt b/134/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7503c8f33b3a7d1f0876e6a6238d2d82e1fc64e7 --- /dev/null +++ b/134/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Radical left neck dissection, Panendoscopy diff --git a/134/surgery_report.txt b/134/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0f8ffbd1f3989f05fce9b89038dda86052ada98 --- /dev/null +++ b/134/surgery_report.txt @@ -0,0 +1 @@ +First consultation with the anesthetist. Then advance the 0° telescope through the glottic plane into the trachea. Inconspicuous mucosal conditions in the area of the trachea. Further advancement of the endoscope into the bronchial system on both sides. Inconspicuous mucosal conditions here. The bronchi are inspected up to the exit of the segmental bronchi. Now infiltrate the patient. There are no abnormalities in the glottis, subglottis and supraglottis. There are also no special features in the hypopharyngeal region on both sides or in the postcricoid region. Raising of the soft palate. Inspection of the nasopharynx: No special features here either. Now advance the flexible telescope into the stomach. Careful mirroring back. No special features in the area of the esophagus. Inspection of the oropharynx: Normal findings in the area of the oropharynx on the right side. No changes to the mucosa in the area of the tonsil or in the area of the right base of the tongue. Now inspection of the oropharynx on the left side. There is a clear induration of the tonsil in the area of the lower half, which corresponds to the CT findings. The tumor borders on the base of the tongue, but does not merge into the base of the tongue. Final inspection of the oral cavity. Inconspicuous mucosal conditions. All inspections with the aid of the endoscope or microscope. Now adjust with the tonsil retractor and expose the tumor. Now wide incision of the tonsil in the sense of a tumor tonsillectomy. Dissection towards the base of the tongue. In the area of the base of the tongue, remove the tissue adjacent to the tonsil. The tumor, which can be clearly defined by palpation, is incised in the healthy area, whereby the mucosa is also resected up to the middle of the pharynx. The tumor is removed in the area of the base of the tongue with careful hemostasis. The specimen is marked and sent as a whole for frozen section histology. diagnoses the tonsil as the primary tumor on the one hand and a clear resection of the tumor in healthy tissue on the other. Careful hemostasis in the oropharynx area again. Insertion of a gastric tube. Repositioning of the patient. Abjode and cover the left neck. Then application of local anesthesia. Now skin incision from the mastoid to the clavicle. The scar made during the previous operation is included in the incision. Now cut through the subcutaneous tissue and cut through the platysma. In view of the previous operation, which took place 12 days ago, extremely difficult dissection conditions, particularly in the area of levels I, II and III. The tissue here is clearly caked. Exposure of the internal jugular vein. Exposure of the common carotid artery, exposure of the internal and external carotid artery, exposure of the branches of the external carotid artery. Visualization of the hypoglossal nerve. Visualization of the vagus nerve. Exposure of the accessorius nerve. Due to the previous operation, there is a pronounced conglomerate in the area of the upper venous angle. This conglomerate cannot be safely separated from the internal jugular vein under oncological aspects, so that a radical neck dissection, in the sense of a resection of the internal jugular vein, is performed. Separation of the internal jugular vein cranial to the inflow of the thyroid vein and dissection cranially. Exposure of the hypoglossal nerve. Separation of the internal jugular vein below the base of the skull. Dissection of the facial vein and removal of the tumor conglomerate in the area of levels I, II and III. Now dissection in the area of levels IV and V after exposing the accessorius nerve and exposing the deep neck muscles and the phrenic nerve. The resection extends below the omohyoid muscle. This results in a radical neck dissection, whereby levels Ia, II, III, IV and V are included in the resection. Repositioning of the above-mentioned structures, which were removed from their beds during neurolysis and are repositioned in their beds at the end of the operation (vagus nerve, hypoglossal nerve, accessory nerve, common carotid artery, internal carotid artery, external carotid artery). Rinse the neck with water and hydrogen. Careful hemostasis. Insertion of a Redon drain. Wound closure in layers. Now re-inspect the oral cavity. The resection bed is dry and free of irritation. Final discussion with the anesthetist, in the sense of a consultation. The patient is transferred to the recovery ward. \ No newline at end of file diff --git a/135/InvasionFront_CD3_block14_x5_y3_patient135_0.json b/135/InvasionFront_CD3_block14_x5_y3_patient135_0.json new file mode 100644 index 0000000000000000000000000000000000000000..755031f027f8374c5fa0197c433c25cefb5025ce --- /dev/null +++ b/135/InvasionFront_CD3_block14_x5_y3_patient135_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17390.8, + "Centroid Y µm": 11419.0, + "Num Detections": 19067, + "Num Negative": 16899, + "Num Positive": 2168, + "Positive %": 11.37, + "Num Positive per mm^2": 961.36 + } +} \ No newline at end of file diff --git a/135/InvasionFront_CD3_block14_x6_y3_patient135_1.json b/135/InvasionFront_CD3_block14_x6_y3_patient135_1.json new file mode 100644 index 0000000000000000000000000000000000000000..519b3e9ffdcdedea7c0b08c9f295f958d8da7051 --- /dev/null +++ b/135/InvasionFront_CD3_block14_x6_y3_patient135_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19789.5, + "Centroid Y µm": 11493.9, + "Num Detections": 17216, + "Num Negative": 15211, + "Num Positive": 2005, + "Positive %": 11.65, + "Num Positive per mm^2": 894.34 + } +} \ No newline at end of file diff --git a/135/InvasionFront_CD8_block14_x5_y3_patient135_0.json b/135/InvasionFront_CD8_block14_x5_y3_patient135_0.json new file mode 100644 index 0000000000000000000000000000000000000000..13ea917c18df615c21ae62846de34136b1b2de2c --- /dev/null +++ b/135/InvasionFront_CD8_block14_x5_y3_patient135_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17041.0, + "Centroid Y µm": 7321.1, + "Num Detections": 15301, + "Num Negative": 12730, + "Num Positive": 2571, + "Positive %": 16.8, + "Num Positive per mm^2": 1311.1 + } +} \ No newline at end of file diff --git a/135/InvasionFront_CD8_block14_x6_y3_patient135_1.json b/135/InvasionFront_CD8_block14_x6_y3_patient135_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c716dadb94dff82ef4f039f53d6ee7708c7136c0 --- /dev/null +++ b/135/InvasionFront_CD8_block14_x6_y3_patient135_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19439.7, + "Centroid Y µm": 7321.1, + "Num Detections": 16461, + "Num Negative": 14317, + "Num Positive": 2144, + "Positive %": 13.02, + "Num Positive per mm^2": 1045.9 + } +} \ No newline at end of file diff --git a/135/TumorCenter_CD3_block14_x5_y3_patient135_0.json b/135/TumorCenter_CD3_block14_x5_y3_patient135_0.json new file mode 100644 index 0000000000000000000000000000000000000000..459e16877894537c1c253567a181644176eb7671 --- /dev/null +++ b/135/TumorCenter_CD3_block14_x5_y3_patient135_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17165.9, + "Centroid Y µm": 8245.6, + "Num Detections": 15706, + "Num Negative": 12950, + "Num Positive": 2756, + "Positive %": 17.55, + "Num Positive per mm^2": 1289.2 + } +} \ No newline at end of file diff --git a/135/TumorCenter_CD3_block14_x6_y3_patient135_1.json b/135/TumorCenter_CD3_block14_x6_y3_patient135_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a0765ba8264fad463b6c56eb2bbe3c40a874ab4 --- /dev/null +++ b/135/TumorCenter_CD3_block14_x6_y3_patient135_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19589.6, + "Centroid Y µm": 8420.5, + "Num Detections": 10728, + "Num Negative": 8939, + "Num Positive": 1789, + "Positive %": 16.68, + "Num Positive per mm^2": 1162.1 + } +} \ No newline at end of file diff --git a/135/TumorCenter_CD8_block14_x5_y3_patient135_0.json b/135/TumorCenter_CD8_block14_x5_y3_patient135_0.json new file mode 100644 index 0000000000000000000000000000000000000000..adbcc772e8a067244695063e960b50f7ec4be6ec --- /dev/null +++ b/135/TumorCenter_CD8_block14_x5_y3_patient135_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 8320.6, + "Num Detections": 15200, + "Num Negative": 13323, + "Num Positive": 1877, + "Positive %": 12.35, + "Num Positive per mm^2": 909.19 + } +} \ No newline at end of file diff --git a/135/TumorCenter_CD8_block14_x6_y3_patient135_1.json b/135/TumorCenter_CD8_block14_x6_y3_patient135_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a555b77f6de6929199cb773f18c52330958c819a --- /dev/null +++ b/135/TumorCenter_CD8_block14_x6_y3_patient135_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 8320.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/135/history_text.txt b/135/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..535f2664732bcab0854e4c0ebc9567a66796b776 --- /dev/null +++ b/135/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma left tongue margin cT2-3. Therefore, the above-mentioned surgery is now indicated. \ No newline at end of file diff --git a/135/icd_codes.txt b/135/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/135/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/135/ops_codes.txt b/135/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e333012556ef58848171b0972a3fd0e0d40aaec2 --- /dev/null +++ b/135/ops_codes.txt @@ -0,0 +1 @@ +Inzision Zungenrand[5-250.0 ] Transorale Hemiglossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Temporäre Tracheotomie[5-311.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Entnahme freier Radialis-Lappen[5-858.23 L] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] \ No newline at end of file diff --git a/135/patient_clinical_data.json b/135/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5a66daf196b20df516fcb61a8737b2b3bfc873ff --- /dev/null +++ b/135/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/135/patient_pathological_data.json b/135/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b76e11b9eacb6dc088d41d5028ed71b8e1712a17 --- /dev/null +++ b/135/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "135", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/135/surgery_description.txt b/135/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4a32a0c0316385fb92beff57f7101788c94e9eb4 --- /dev/null +++ b/135/surgery_description.txt @@ -0,0 +1 @@ +Left tumor resection, Neck dissection including tracheotomy diff --git a/135/surgery_report.txt b/135/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..80273813d8f384a344e35b19e6de407a38176680 --- /dev/null +++ b/135/surgery_report.txt @@ -0,0 +1 @@ +First tracheotomy and PEG insertion by : Head positioning in a slightly reclined position. Entry with the laryngoscope and charging of the piriform sinus. Entering with the flexible gastroesophagoscope and advancing into the stomach. Air insufflation into the stomach and elevation of the upper body by approx. 30 %. Perform positive diaphanoscopy. PEG placement in the usual manner using the suture pull-through method without complications. Now repositioning of the patient. Injection of Suprarenin. Sterile wiping and draping. Horizontal skin incision over 2 cm just below the cricoid cartilage. Dissection of the infralaryngeal muscles. Split the infralaryngeal muscles in the midline and dissect down to the cricoid cartilage. Undermining of the thyroid isthmus and sharp transection of the isthmus after bipolar coagulation. Identification of the anterior tracheal wall. Creation of a visor tracheotomy in the 2nd to 3rd intratracheal fissure. Insertion of an 8-gauge cannula after epithelialization of the tracheostoma in the usual manner. Then tumor resection transorally by : insertion of mouth retractor. Exposure of the tumor. The tumor is incised on all sides at a distance of at least 1.5 cm. This results in an almost complete hemiglossectomy. The sublingual gland is resected, as are larger parts of the floor of the mouth and larger parts of the base of the tongue. The preparation is sent in toto and thread-marked for a frozen section. Here all margins are healthy. Thus R0 resection. Subsequent neck dissection. The undersigned first performs the neck dissection on the left side after sterile washing and infiltration with local anesthetic containing adrenaline. This is followed by a skin incision along the front edge of the sternocleidomastoid muscle. Dissection of the platysma flap and fixation in the usual manner. Subsequent skeletonization of the vascular nerve sheath. Identification and protection of the hypoglossal nerve and accessorius nerve. Evacuation of regions II to IV. There is no caliber or other type of facial vein. Subsequent evacuation of region I after submandibulectomy. This already creates a defect in the enoral direction, where the flap will be inserted later. Dissection of the digastric muscle at its tendon. Subsequent skeletonization of the superior thyroid artery, which will later be used for anastomosis. Then transition to the operation on the right side. In principle, the same procedure is used here. There are no clinically manifest lymph node metastases on either side. Elevation of the radial forearm flap on the left by : Palpatory identification of the distal radial artery. Marking of the flap borders (8 x 6 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. After appropriate removal of the radial lobe graft, it is sutured in place enorally with a single button suture and the stem is passed through the defect outwards into the neck. The arterial anastomosis is then made at the superior thyroid artery. The venous anastomosis is made through a large cubital vein as an end-to-side anastomosis to the internal jugular vein. Insertion of a Redon suction drainage and an Easy-flow drainage. Wound dressing on the left after multi-layer wound closure. Completion of the mucocutaneous anastomosis in the area of the tracheostoma. Re-intubation of the patient. On subsequent inspection of the flap, the flap is vital. Arterial blood is present at the distal puncture. End of the operation. Transfer of the patient to anesthesia. Patient goes to the intensive care unit for postoperative monitoring. Please monitor the flap for approx. 5 days clinically or by means of Doppler monitoring. Feeding via the inserted PEG tube for 7 to 10 days, then diet build-up or swallowing training. Please continue antibiotics that were started intraoperatively or preoperatively for 1 week. Postoperative presentation at the interdisciplinary tumor conference after receipt of the final histology. \ No newline at end of file diff --git a/136/InvasionFront_CD3_block21_x3_y1_patient136_0.json b/136/InvasionFront_CD3_block21_x3_y1_patient136_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7ebd795afa023001b4ab5093cd7966f13832a104 --- /dev/null +++ b/136/InvasionFront_CD3_block21_x3_y1_patient136_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14192.5, + "Centroid Y µm": 12843.2, + "Num Detections": 25424, + "Num Negative": 24552, + "Num Positive": 872, + "Positive %": 3.43, + "Num Positive per mm^2": 320.17 + } +} \ No newline at end of file diff --git a/136/InvasionFront_CD3_block21_x4_y1_patient136_1.json b/136/InvasionFront_CD3_block21_x4_y1_patient136_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a11c0959e1eeb625d18fea39d21dcf068e739593 --- /dev/null +++ b/136/InvasionFront_CD3_block21_x4_y1_patient136_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 12918.2, + "Num Detections": 20340, + "Num Negative": 20059, + "Num Positive": 281, + "Positive %": 1.382, + "Num Positive per mm^2": 126.21 + } +} \ No newline at end of file diff --git a/136/InvasionFront_CD8_block21_x3_y1_patient136_0.json b/136/InvasionFront_CD8_block21_x3_y1_patient136_0.json new file mode 100644 index 0000000000000000000000000000000000000000..857e197b21fd3634ba37736d7ebd6fe557a5a282 --- /dev/null +++ b/136/InvasionFront_CD8_block21_x3_y1_patient136_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 2473.7, + "Num Detections": 25432, + "Num Negative": 25252, + "Num Positive": 180, + "Positive %": 0.7078, + "Num Positive per mm^2": 65.08 + } +} \ No newline at end of file diff --git a/136/InvasionFront_CD8_block21_x4_y1_patient136_1.json b/136/InvasionFront_CD8_block21_x4_y1_patient136_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a81c949a98516b83f71f3cc1e8e64adba09fa669 --- /dev/null +++ b/136/InvasionFront_CD8_block21_x4_y1_patient136_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 2448.7, + "Num Detections": 24986, + "Num Negative": 24940, + "Num Positive": 46, + "Positive %": 0.1841, + "Num Positive per mm^2": 17.26 + } +} \ No newline at end of file diff --git a/136/TumorCenter_CD3_block21_x3_y1_patient136_0.json b/136/TumorCenter_CD3_block21_x3_y1_patient136_0.json new file mode 100644 index 0000000000000000000000000000000000000000..22bec887534b6c7e0ebf524a6453ed73c8154e8c --- /dev/null +++ b/136/TumorCenter_CD3_block21_x3_y1_patient136_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10694.3, + "Centroid Y µm": 4172.8, + "Num Detections": 22954, + "Num Negative": 21855, + "Num Positive": 1099, + "Positive %": 4.788, + "Num Positive per mm^2": 432.18 + } +} \ No newline at end of file diff --git a/136/TumorCenter_CD3_block21_x4_y1_patient136_1.json b/136/TumorCenter_CD3_block21_x4_y1_patient136_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b47e5bc36835190736c3fd2ddb40ccbe51eea732 --- /dev/null +++ b/136/TumorCenter_CD3_block21_x4_y1_patient136_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 3947.9, + "Num Detections": 26515, + "Num Negative": 25709, + "Num Positive": 806, + "Positive %": 3.04, + "Num Positive per mm^2": 292.6 + } +} \ No newline at end of file diff --git a/136/TumorCenter_CD8_block21_x3_y1_patient136_0.json b/136/TumorCenter_CD8_block21_x3_y1_patient136_0.json new file mode 100644 index 0000000000000000000000000000000000000000..543c296455e046cfcfd68cb09d7e59eec2e99e23 --- /dev/null +++ b/136/TumorCenter_CD8_block21_x3_y1_patient136_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 17315.8, + "Num Detections": 23436, + "Num Negative": 23038, + "Num Positive": 398, + "Positive %": 1.698, + "Num Positive per mm^2": 153.59 + } +} \ No newline at end of file diff --git a/136/TumorCenter_CD8_block21_x4_y1_patient136_1.json b/136/TumorCenter_CD8_block21_x4_y1_patient136_1.json new file mode 100644 index 0000000000000000000000000000000000000000..445535a199f210a34c9d60a1ff65c730a979b4b7 --- /dev/null +++ b/136/TumorCenter_CD8_block21_x4_y1_patient136_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16941.0, + "Centroid Y µm": 17041.0, + "Num Detections": 27209, + "Num Negative": 26889, + "Num Positive": 320, + "Positive %": 1.176, + "Num Positive per mm^2": 113.19 + } +} \ No newline at end of file diff --git a/136/history_text.txt b/136/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c720a411cea57418f11482a1aab0497c1156ee44 --- /dev/null +++ b/136/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed squamous cell carcinoma of the larynx, which extends subglottically on computed tomography and clearly infiltrates the thyroid gland on the left side. Therefore, the above-mentioned operation is indicated. \ No newline at end of file diff --git a/136/icd_codes.txt b/136/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/136/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/136/ops_codes.txt b/136/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c92f63fb9a853cce678c7214fc6f7e13152c50ed --- /dev/null +++ b/136/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie: Mit Pharyngektomie und Schilddrüsenresektion: Rekonstruktion mit lokaler Schleimhaut[5-303.21 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 B] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Hemithyreoidektomie: Ohne Parathyreoidektomie[5-061.0 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/136/patient_clinical_data.json b/136/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7580f4fe90b3a2e5c87d21cc6f637dbc29f1d396 --- /dev/null +++ b/136/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/136/patient_pathological_data.json b/136/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..95531da6d000c9831ed0410a1250eaa82890eecc --- /dev/null +++ b/136/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "136", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 56, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/136/surgery_description.txt b/136/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7049f0a45573efdc4f3e42e79abadc550617e6f8 --- /dev/null +++ b/136/surgery_description.txt @@ -0,0 +1 @@ +Complete laryngectomy with hemithyroidectomy, Neck dissection, PEG placement diff --git a/136/surgery_report.txt b/136/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2a5b3b0b1d826950c461687b319365b7257d4a4b --- /dev/null +++ b/136/surgery_report.txt @@ -0,0 +1 @@ +After induction of anaesthesia, a tracheoscopy is first attempted, which is not possible due to the complete alteration of the glottis by the tumor. The patient is then anesthetized via the existing tracheostomy. The surgeon then intubates the patient naso-tracheally to facilitate the first steps of the operation. The esophagogastroscopy is then performed and the PEG tube is inserted in the typical manner. After a positive diaphanoscopy, 4 ml of xylocaine with adrenaline is injected, the Troikart is inserted and the tube is placed using the fall-through method. Now inject 10 ml xylocaine with adrenaline on both cervical sides and then abjode the neck. An apron flap is then passed through the upper edge of the existing tracheostoma. The subplatysmal formation of the apron flap is then performed up to the level of the hyoid bone. The neck is then dissected on the right side. Dissection along the anterior edge of the sternocleidomastoid. Expose the omohyoid muscle and the digastric muscle. Identification of the accessorius nerve. Then dissect the internal jugular vein from caudal to cranial. At the same time, the facial nerve is also exposed, dissected and protected. Then identify the hypoglossal nerve and form the complete middle preparation. After completion of the neck, the lateral preparation is then also dissected far caudally, starting from level IIb and sparing the accessory nerve and the plexus branches. Now proceed identically on the left side. The sternocleidomastoid muscle is also exposed here. The omohyoid muscle and the digastricus venter posterior muscle are then exposed and the accessorius nerve is identified and spared. Finally, the internal jugular vein is dissected from caudal to cranial and a very deep facial vein is also dissected and spared, as on the opposite side. After identifying the hypoglossal nerve and skeletonizing the submandibular gland, the medial neck preparation is also performed on the left side. After completion of the LE, the lateral preparation is also made here, sparing the plexus branches and the accessorius nerve, whereby it should be noted here that clearly enlarged lymph nodes were palpated far caudally on both sides. Now prepare for the laryngectomy: For this purpose, the cervical vascular sheath is first dissected medially on the right side up to the scalene muscles. Cranially, the bundle of the superior laryngeal nerve can be identified and ligated. The superior thyroid artery is then followed caudally, as removal of the thyroid gland is unavoidable on the left side, the thyroid gland is very carefully spared on the right side, but the paratracheal area and along the cricoid cartilage are now dissected in depth and the vessels and nerves are successively severed. This ensures that the thyroid gland is separated from the trachea without further injury. The constrictor muscle of the pharynx is then separated from the thyroid cartilage on the right side using the electric needle and the upper thyroid horn is exposed. The piriform sinus is then freed from the inner side of the thyroid cartilage using the Freer. A similar procedure is now performed on the left side. Here, the cervical vascular sheath is also dissected medially until the scalene muscles are reached. The bundle of the superior laryngeal nerve is then ligated and severed; as the thyroid gland is also to be removed here, the thyroid gland is dissected caudally laterally. Prior to this, the superior thyroid artery is ligated and transected. The omohyoid muscle is then also cut and dissected lateral to the thyroid gland. Caudal to the thyroid gland, the resection is now completed up to the tracheal side wall. Now use the electric needle to cut through the pharyngeal constrictor muscle and the upper thyroid horn on the left side as well. Then free the piriform sinus from the inner side of the thyroid cartilage with the Freer. The hyoid bone is now exposed and completely freed laterally. Then dissect into the depth of the pre-epiglottic space until the petiolus of the epiglottis is reached, from there dissect subperichondrally on the lingual side of the epiglottis until the free edge is reached. The pharynx is now opened here. As the tumor mainly extends subglottically, the preparation is made very close along the pharyngo-epiglottic fold and along the arytenoid region and the arytenoid cusps, sparing as much mucosa as possible. This works very well. The tumor, which has infiltrated the thyroid gland and also extends into the postcricoid region, can now be easily palpated. For this reason, the dissection is now carried out very carefully, not directly along the cricoid cartilage, but along the hypopharyngeal mucosa, so that the upper esophageal sphincter is also removed in the dissection. Overall, the esophagus must be dissected very far caudally so that it is no longer in direct contact with the trachea, which was also separated caudally of the cricoid cartilage with approx. 3 tracheal clamps. First cut on the right side and then completely resected at a distance of approx. 1 cm from the tumor, which not only infiltrated the subglottic space but also the trachea on the left side. The complete preparation of the laryngectomy and thyroid cartilage removal is then sent for frozen section diagnostics. A site in the postcricoid region that was clinically suspicious for tumor infiltration is clarified again with an additional frozen section diagnosis; this was also tumor-free. All frozen sections were found to be tumor-free by the pathology department. In between, the lateral neck preparations were carried out. Finally, the pharynx was reconstructed. For this, the pharyngeal tube is first readapted using inverted 3-0 Vicryl sutures. The 2nd suture is then placed submucosally approximately 5 mm lateral to the primary suture, followed by a 3rd layer as far as possible, which includes the preserved M. constrictor pharyngis. After careful hemostasis with hydrogen and Ringer's irrigation, 2 redon drainage tubes are placed on the right and left and the wound is closed in two layers using subcutaneous 3-0 and 4-0 Vicryl sutures. The tracheostoma is naturally formed around the stump of the trachea with 2-0 Mercelene sutures. Re-intubation to a 10 mm cannula. The patient was given 2 x Unacid 3 g intraoperatively, which is to be continued for 3 days, and 1 x 250 SDH additionally due to his lung problems. \ No newline at end of file diff --git a/137/InvasionFront_CD3_block19_x5_y3_patient137_0.json b/137/InvasionFront_CD3_block19_x5_y3_patient137_0.json new file mode 100644 index 0000000000000000000000000000000000000000..936187c297053022c360cb85b5c9c4c9ea3453f8 --- /dev/null +++ b/137/InvasionFront_CD3_block19_x5_y3_patient137_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17590.7, + "Centroid Y µm": 10244.6, + "Num Detections": 20985, + "Num Negative": 20399, + "Num Positive": 586, + "Positive %": 2.792, + "Num Positive per mm^2": 264.93 + } +} \ No newline at end of file diff --git a/137/InvasionFront_CD3_block19_x6_y3_patient137_1.json b/137/InvasionFront_CD3_block19_x6_y3_patient137_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7491f10398091fadc34365cbf7d660a70b77e263 --- /dev/null +++ b/137/InvasionFront_CD3_block19_x6_y3_patient137_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20139.3, + "Centroid Y µm": 10344.5, + "Num Detections": 24336, + "Num Negative": 23482, + "Num Positive": 854, + "Positive %": 3.509, + "Num Positive per mm^2": 361.84 + } +} \ No newline at end of file diff --git a/137/InvasionFront_CD8_block19_x5_y3_patient137_0.json b/137/InvasionFront_CD8_block19_x5_y3_patient137_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f83d6787c3f80229941e2f4ef8cc11f27bb0d55 --- /dev/null +++ b/137/InvasionFront_CD8_block19_x5_y3_patient137_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16991.0, + "Centroid Y µm": 17615.7, + "Num Detections": 18555, + "Num Negative": 18417, + "Num Positive": 138, + "Positive %": 0.7437, + "Num Positive per mm^2": 57.58 + } +} \ No newline at end of file diff --git a/137/InvasionFront_CD8_block19_x6_y3_patient137_1.json b/137/InvasionFront_CD8_block19_x6_y3_patient137_1.json new file mode 100644 index 0000000000000000000000000000000000000000..268c5d3d45c25d3c694afc73d2da9258f26f1df2 --- /dev/null +++ b/137/InvasionFront_CD8_block19_x6_y3_patient137_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19589.6, + "Centroid Y µm": 17665.6, + "Num Detections": 21142, + "Num Negative": 20447, + "Num Positive": 695, + "Positive %": 3.287, + "Num Positive per mm^2": 289.46 + } +} \ No newline at end of file diff --git a/137/TumorCenter_CD3_block19_x5_y3_patient137_0.json b/137/TumorCenter_CD3_block19_x5_y3_patient137_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5702bd8b1e7542ada763dcab68d8c98983c4d466 --- /dev/null +++ b/137/TumorCenter_CD3_block19_x5_y3_patient137_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 7895.8, + "Num Detections": 21446, + "Num Negative": 21112, + "Num Positive": 334, + "Positive %": 1.557, + "Num Positive per mm^2": 140.09 + } +} \ No newline at end of file diff --git a/137/TumorCenter_CD3_block19_x6_y3_patient137_1.json b/137/TumorCenter_CD3_block19_x6_y3_patient137_1.json new file mode 100644 index 0000000000000000000000000000000000000000..84b91e1a2b94a0fbeb0085a2f7757adb533f1711 --- /dev/null +++ b/137/TumorCenter_CD3_block19_x6_y3_patient137_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 7496.0, + "Num Detections": 21766, + "Num Negative": 21653, + "Num Positive": 113, + "Positive %": 0.5192, + "Num Positive per mm^2": 45.98 + } +} \ No newline at end of file diff --git a/137/TumorCenter_CD8_block19_x5_y3_patient137_0.json b/137/TumorCenter_CD8_block19_x5_y3_patient137_0.json new file mode 100644 index 0000000000000000000000000000000000000000..137b17b4f58294df43adadcb7baf1c0b97859948 --- /dev/null +++ b/137/TumorCenter_CD8_block19_x5_y3_patient137_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 18340.3, + "Num Detections": 22067, + "Num Negative": 21196, + "Num Positive": 871, + "Positive %": 3.947, + "Num Positive per mm^2": 359.74 + } +} \ No newline at end of file diff --git a/137/TumorCenter_CD8_block19_x6_y3_patient137_1.json b/137/TumorCenter_CD8_block19_x6_y3_patient137_1.json new file mode 100644 index 0000000000000000000000000000000000000000..559a63c3f0f3d431e13edf84649a6ae8bb628452 --- /dev/null +++ b/137/TumorCenter_CD8_block19_x6_y3_patient137_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21219.5, + "Centroid Y µm": 18145.1, + "Num Detections": 23928, + "Num Negative": 23787, + "Num Positive": 141, + "Positive %": 0.5893, + "Num Positive per mm^2": 56.96 + } +} \ No newline at end of file diff --git a/137/history_text.txt b/137/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/137/icd_codes.txt b/137/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15cdf3cedbb267117d620058bfef3b6f5d6fd43f --- /dev/null +++ b/137/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/137/ops_codes.txt b/137/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b92b24bcaa496c9a2e211d4e030c16df55d4aff4 --- /dev/null +++ b/137/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Permanente Tracheotomie[5-312.0 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] \ No newline at end of file diff --git a/137/patient_clinical_data.json b/137/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2f354a59a4427d038dc7cf1b3cc11c4cb3651b9a --- /dev/null +++ b/137/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 67, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/137/patient_pathological_data.json b/137/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4d6e44f13c48fcc0f6f6aa2839ef0ec744bba696 --- /dev/null +++ b/137/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "137", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 32, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/137/surgery_description.txt b/137/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d2e72262ad0781d5bfa7f5116b74607ba541eb8 --- /dev/null +++ b/137/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Tracheotomy, Defect coverage, PEG placement, Provox Prosthesis diff --git a/137/surgery_report.txt b/137/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6ddbbccc98d61ed76c1b17e56ef6348e3e8d0d21 --- /dev/null +++ b/137/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesiology colleagues, followed by an examination of the glottis region and the trachea using a rigid 0° scope. An exophytic tumor was found, starting at the morgue sinus on the left side with transition to the vocal fold and subtle subglottic extension. Then intubation by the surgeon. Further inspection with the Kleinsasser tube and confirmation of the findings. The right arytenoid cartilage as well as 3/4 of the right vocal fold and also the pocket fold are not affected on the right side, therefore an attempt is first made to remove the larynx subtotally and preserve the rest. At the beginning, the flexible esophagoscope is used to enter the larynx and the stomach is viewed, which is normal on all sides. Then attempt to perform a diaphanoscopy; this is not possible, even after repositioning the patient, so a PEG is not inserted. Now insertion of a nasogastric tube and fixation of this to the septum. Then sterile washing and draping. First start with the tracheostomy. To do this, make a skin incision below the cricoid cartilage and dissect the thyroid gland. This reveals a large thyroid nodule on the left side. Dissection of the thyroid isthmus and exposure of the anterior wall of the trachea. Insertion between the 3rd and 4th tracheal cartilage and creation of a tracheotomy. Re-intubation, then sterile washing and draping again. Then creation of an apron flap in the usual manner. This is complicated as the patient has undergone 3 ventral operations on the cervical spine and there is scarring here. Exposure of the larynx, release of the larynx, release of the piriform sinus on both sides. Cut the sternohyoid muscle on both sides and then enter the supraglottic larynx from the right and inspect the tumor region. The tumor is now carefully cut around from the posterior side while preserving the epiglottis. Further incision is made caudally. The right arytenoid cartilage as well as 3/4 of the right vocal fold and 3/4 of the pocket fold can be preserved on the right side. Not on the left side. Then further dissection caudally. Exposure of the cricoid cartilage. It is now clear that the cricoid cartilage is macroscopically infiltrated on the left side; the arytenoid on the left side must also be resected down to the interary region. Therefore, the concept of partial laryngectomy is abandoned and a laryngectomy is performed. The larynx is now removed below the cricoid cartilage. Removal of marginal samples, these are sent for histology, all marginal samples are tumor-free. In the pharyngeal side wall on both sides, there is still evidence of carcinoma in situ, therefore another resection and another final marginal sample is taken and sent for final histology. Macroscopically no evidence of tumor, especially on the right side there had never been a tumor. Then completion of the neck dissection. Instead, visualization of the anterior border of the sternocleidomastoid muscle on both sides. Exposure of the accessory muscle, exposure of the cervical vascular sheath. Free preparation of the internal jugular vein and removal of the neck preparation while protecting the plexus branches on both sides. Then placement of a Provox prosthesis size 8.0 Provox Vega in the usual manner. Then perform a lateral esophageal myotomy on the left side in the usual manner. Resection of the insertions of the sternocleidomastoid muscle. Insertion of 2 Redondra rings. Then pharyngeal suture in 3 layers in the usual manner. The base of the tongue was partially released beforehand. At the end, two-layer wound closure and suturing of the tracheotoma. Insertion of a 10 mm tracheostomy tube and completion of the procedure without complications. Collar dressing at the end. Antibiotics for 24 hours and neck bandage for one week. X-ray pre-swallow from the 10th postoperative day. \ No newline at end of file diff --git a/138/InvasionFront_CD3_block9_x5_y5_patient138_0.json b/138/InvasionFront_CD3_block9_x5_y5_patient138_0.json new file mode 100644 index 0000000000000000000000000000000000000000..69ff2a5328a30ae29474af1cd644d8ab3cde442b --- /dev/null +++ b/138/InvasionFront_CD3_block9_x5_y5_patient138_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18015.5, + "Centroid Y µm": 13567.8, + "Num Detections": 7029, + "Num Negative": 6486, + "Num Positive": 543, + "Positive %": 7.725, + "Num Positive per mm^2": 659.46 + } +} \ No newline at end of file diff --git a/138/InvasionFront_CD3_block9_x6_y5_patient138_1.json b/138/InvasionFront_CD3_block9_x6_y5_patient138_1.json new file mode 100644 index 0000000000000000000000000000000000000000..014692989e8f40b0cafcd9237c892f14887f30b1 --- /dev/null +++ b/138/InvasionFront_CD3_block9_x6_y5_patient138_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20789.0, + "Centroid Y µm": 13842.7, + "Num Detections": 23750, + "Num Negative": 18121, + "Num Positive": 5629, + "Positive %": 23.7, + "Num Positive per mm^2": 2255.3 + } +} \ No newline at end of file diff --git a/138/InvasionFront_CD8_block9_x5_y5_patient138_0.json b/138/InvasionFront_CD8_block9_x5_y5_patient138_0.json new file mode 100644 index 0000000000000000000000000000000000000000..abcea79365308b5a2f29224454cd5eb7b2d414be --- /dev/null +++ b/138/InvasionFront_CD8_block9_x5_y5_patient138_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17790.6, + "Centroid Y µm": 17340.8, + "Num Detections": 6638, + "Num Negative": 5870, + "Num Positive": 768, + "Positive %": 11.57, + "Num Positive per mm^2": 1020.5 + } +} \ No newline at end of file diff --git a/138/InvasionFront_CD8_block9_x6_y5_patient138_1.json b/138/InvasionFront_CD8_block9_x6_y5_patient138_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7fcbb28881f1316c490391b1c14e23a3c7dfa995 --- /dev/null +++ b/138/InvasionFront_CD8_block9_x6_y5_patient138_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20489.2, + "Centroid Y µm": 17465.8, + "Num Detections": 26406, + "Num Negative": 24306, + "Num Positive": 2100, + "Positive %": 7.953, + "Num Positive per mm^2": 868.07 + } +} \ No newline at end of file diff --git a/138/TumorCenter_CD3_block9_x5_y5_patient138_0.json b/138/TumorCenter_CD3_block9_x5_y5_patient138_0.json new file mode 100644 index 0000000000000000000000000000000000000000..089583da345894e37e2311160c81a8bf733fb9b3 --- /dev/null +++ b/138/TumorCenter_CD3_block9_x5_y5_patient138_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16566.2, + "Centroid Y µm": 18365.3, + "Num Detections": 21772, + "Num Negative": 13714, + "Num Positive": 8058, + "Positive %": 37.01, + "Num Positive per mm^2": 3125.0 + } +} \ No newline at end of file diff --git a/138/TumorCenter_CD3_block9_x6_y5_patient138_1.json b/138/TumorCenter_CD3_block9_x6_y5_patient138_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a55e067a1c46b9e3b8634d9607502416832eab6 --- /dev/null +++ b/138/TumorCenter_CD3_block9_x6_y5_patient138_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19164.9, + "Centroid Y µm": 18565.2, + "Num Detections": 24747, + "Num Negative": 14497, + "Num Positive": 10250, + "Positive %": 41.42, + "Num Positive per mm^2": 3879.6 + } +} \ No newline at end of file diff --git a/138/TumorCenter_CD8_block9_x5_y5_patient138_0.json b/138/TumorCenter_CD8_block9_x5_y5_patient138_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e8a1aa16f64d549543011a120f292ced52730f13 --- /dev/null +++ b/138/TumorCenter_CD8_block9_x5_y5_patient138_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 13168.0, + "Num Detections": 24635, + "Num Negative": 20221, + "Num Positive": 4414, + "Positive %": 17.92, + "Num Positive per mm^2": 1733.1 + } +} \ No newline at end of file diff --git a/138/TumorCenter_CD8_block9_x6_y5_patient138_1.json b/138/TumorCenter_CD8_block9_x6_y5_patient138_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bfde875019176b1fa9eb49f9b00860face820fda --- /dev/null +++ b/138/TumorCenter_CD8_block9_x6_y5_patient138_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 13143.0, + "Num Detections": 29173, + "Num Negative": 24862, + "Num Positive": 4311, + "Positive %": 14.78, + "Num Positive per mm^2": 1630.5 + } +} \ No newline at end of file diff --git a/138/history_text.txt b/138/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..05d414e1d37a5508640bbdd0126faf2aad5ab796 --- /dev/null +++ b/138/history_text.txt @@ -0,0 +1 @@ +Mr. had previously been diagnosed with a G3-differentiated basaloid HPV-16-positive squamous cell carcinoma on the left cervical side. During the initial operation, a suspicious finding was found in the area of the left upper tonsil pole. Pathohistologically, however, there was no evidence of a primary tumor. Therefore, initially suspected CUP syndrome and therefore further appropriate CUP diagnostics. The subsequent PET-CT showed no evidence of further metastases in addition to the metastatic conglomerate on the left side. Only a slight increase in the area of the left tonsil. There is now an indication for a left tonsillectomy and frozen section diagnostics. In addition, a modified radical neck dissection on the left side is indicated. Due to the sonomorphologic cN2b neck status and the unremarkable cervical PET findings on the right, a neck dissection on the right side does not appear to be indicated. The patient consented to the planned procedure. \ No newline at end of file diff --git a/138/icd_codes.txt b/138/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa6097eacf18ae8aea8260bca82cce6b0a31ad0c --- /dev/null +++ b/138/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 L] \ No newline at end of file diff --git a/138/ops_codes.txt b/138/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ea454548911e732c72bb5ce1dd44d604af622822 --- /dev/null +++ b/138/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] \ No newline at end of file diff --git a/138/patient_clinical_data.json b/138/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2722e28d1beef43efb5e21f41b7ac952823e542c --- /dev/null +++ b/138/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/138/patient_pathological_data.json b/138/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..aef399cda30256aaf2c1a2bcd28ecc5909b6d235 --- /dev/null +++ b/138/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "138", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN3", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/138/surgery_description.txt b/138/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..50312bf02ac9be42bdb574ea1e368d8a571c1efe --- /dev/null +++ b/138/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Neck dissection diff --git a/138/surgery_report.txt b/138/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..87273ad98f996ee6f74ebd250832cdafb4eff9f8 --- /dev/null +++ b/138/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesia department. Induction of anesthesia and intubation of the patient. Start of tonsillectomy. Insertion of the McIvor oral spatula while protecting the teeth, lips and tongue. Grasping the tonsil and medializing it. Mucosal incision in the area of the fold at the anterior palatal arch. Exposure of the tonsil capsule. Successive dissection along the muscles of the anterior and posterior palatal arch. Exposure of the lower tonsil pole. Bipolar coagulation of the pole vessels. Separation of the tonsil at the lower left pole. This is sent in for frozen section diagnostics. Perform a mucosoplasty. In the meantime, reposition the patient for neck dissection on the left side. Superficial skin disinfection. Infiltration anesthesia. Ablation of the surgical site and sterile draping. Marking of the planned incision from the mastoid over the front edge of the sternocleidomastoid muscle, curving caudally. Cut sharply through the cutis and subcutis as well as the platysma. Exposure of the anterior edge of the sternocleidomastoid muscle. Exposure of the omohyoid muscle as the caudal border. Exposure, displacement, neurolysis and re-embedding of the accessorius nerve and the posterior digastric nerve as the cranial border. Turning to the cervical vascular sheath and exposure of the internal jugular vein and the common carotid artery. Successive detachment of the pronounced metastatic conglomerate from the sternocleidomastoid muscle. A clear displacement layer is visible here, so that intraoperatively no infiltration of the muscle must be assumed. In region II, the jugular vein is adjacent to the metastatic conglomerate. After laborious blunt dissection, however, it can be seen that a displacement layer is also present here. The vein therefore does not appear to be infiltrated by tumor even in the cranial sections. Therefore, successive sharp and blunt dissection and detachment of the metastatic conglomerate from the internal jugular vein. Subsequent successive development of the neck preparation from level IIb via level IIa, III and IV. Palpation reveals further metastases in the deep level IV as well as in level V. Level IV and V are therefore also cleared. A prominent thoracic duct can also be seen in deep level IV. This is grasped and ligated several times. Subsequent hemostasis using bipolar coagulation. There is no chyle flow here. Then develop the medial neck preparation. The superior thyroid artery must be ligated in advance, as there is a strong outflow in the direction of the tumor conglomerate. Finally, palpatory exploration of the wound cavity. There is no evidence of further metastatic nodes. Hemostasis using bipolar coagulation. Wound irrigation with H2O2 and Ringer's solution. Insertion of a 10-gauge Redon drain. Two-layer wound closure with Vicryl 4.0 and Ethilon 5.0. Application of a pressure bandage. In the meantime, a rapid incision was made by telephone, stating that a tonsil carcinoma R0 was resected on the left side as part of the tumor tonsillectomy. A resection is therefore necessary. Final inspection of the tonsil lobe. If the wound bed is dry, the operation is completed without complications. Final consultation with the anesthetist. \ No newline at end of file diff --git a/139/InvasionFront_CD3_block3_x3_y3_patient139_0.json b/139/InvasionFront_CD3_block3_x3_y3_patient139_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bfd957d0030a3c4c4593730bb53372312e7602fa --- /dev/null +++ b/139/InvasionFront_CD3_block3_x3_y3_patient139_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 12368.5, + "Num Detections": 11832, + "Num Negative": 11381, + "Num Positive": 451, + "Positive %": 3.812, + "Num Positive per mm^2": 292.62 + } +} \ No newline at end of file diff --git a/139/InvasionFront_CD3_block3_x4_y3_patient139_1.json b/139/InvasionFront_CD3_block3_x4_y3_patient139_1.json new file mode 100644 index 0000000000000000000000000000000000000000..199f3f8b0940d181367495740ad3d9114815f7b0 --- /dev/null +++ b/139/InvasionFront_CD3_block3_x4_y3_patient139_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 12493.4, + "Num Detections": 19480, + "Num Negative": 18314, + "Num Positive": 1166, + "Positive %": 5.986, + "Num Positive per mm^2": 508.59 + } +} \ No newline at end of file diff --git a/139/InvasionFront_CD8_block3_x3_y3_patient139_0.json b/139/InvasionFront_CD8_block3_x3_y3_patient139_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c22b8afaa4d689680d020de20265337c3bf62a61 --- /dev/null +++ b/139/InvasionFront_CD8_block3_x3_y3_patient139_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12407.5, + "Centroid Y µm": 7407.1, + "Num Detections": 15276, + "Num Negative": 14856, + "Num Positive": 420, + "Positive %": 2.749, + "Num Positive per mm^2": 197.29 + } +} \ No newline at end of file diff --git a/139/InvasionFront_CD8_block3_x4_y3_patient139_1.json b/139/InvasionFront_CD8_block3_x4_y3_patient139_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2c1222aee7d7f664525f3432f7bfe85063760cd --- /dev/null +++ b/139/InvasionFront_CD8_block3_x4_y3_patient139_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15004.6, + "Centroid Y µm": 7238.4, + "Num Detections": 16911, + "Num Negative": 15750, + "Num Positive": 1161, + "Positive %": 6.865, + "Num Positive per mm^2": 510.34 + } +} \ No newline at end of file diff --git a/139/TumorCenter_CD3_block3_x3_y3_patient139_0.json b/139/TumorCenter_CD3_block3_x3_y3_patient139_0.json new file mode 100644 index 0000000000000000000000000000000000000000..20a9fbda8afc421163321372c0236df81254488f --- /dev/null +++ b/139/TumorCenter_CD3_block3_x3_y3_patient139_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11063.8, + "Centroid Y µm": 13721.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/139/TumorCenter_CD3_block3_x4_y3_patient139_1.json b/139/TumorCenter_CD3_block3_x4_y3_patient139_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8532b3aab1a58462b6560e6a31f682b1d940e303 --- /dev/null +++ b/139/TumorCenter_CD3_block3_x4_y3_patient139_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 13748.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/139/TumorCenter_CD8_block3_x3_y3_patient139_0.json b/139/TumorCenter_CD8_block3_x3_y3_patient139_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3596c49e79dcae5aed3475ec781ae1d88f0b4f76 --- /dev/null +++ b/139/TumorCenter_CD8_block3_x3_y3_patient139_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12193.5, + "Centroid Y µm": 9020.2, + "Num Detections": 16515, + "Num Negative": 16024, + "Num Positive": 491, + "Positive %": 2.973, + "Num Positive per mm^2": 234.24 + } +} \ No newline at end of file diff --git a/139/TumorCenter_CD8_block3_x4_y3_patient139_1.json b/139/TumorCenter_CD8_block3_x4_y3_patient139_1.json new file mode 100644 index 0000000000000000000000000000000000000000..194048f649905d92055b62c5c24a48d704ec2848 --- /dev/null +++ b/139/TumorCenter_CD8_block3_x4_y3_patient139_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14717.2, + "Centroid Y µm": 9220.1, + "Num Detections": 19333, + "Num Negative": 18155, + "Num Positive": 1178, + "Positive %": 6.093, + "Num Positive per mm^2": 530.34 + } +} \ No newline at end of file diff --git a/139/history_text.txt b/139/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/139/icd_codes.txt b/139/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/139/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/139/ops_codes.txt b/139/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2cca6bbb11383dba914e411a62ac01f38396e9ec --- /dev/null +++ b/139/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Deckung mit freiem Radialis-Lappen Unterarm[5-858.73 R] Entnahme freier Radialis-Lappen[5-858.23 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/139/patient_clinical_data.json b/139/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0d07aeca7db728b029fc24232def5e33d6422500 --- /dev/null +++ b/139/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/139/patient_pathological_data.json b/139/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..66ea1b3ddf82188c82fad4154142731b9f4da9d4 --- /dev/null +++ b/139/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "139", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2c", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 54, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/139/surgery_description.txt b/139/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2b85a79fe25a0fb232a2266329654a1c57877861 --- /dev/null +++ b/139/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy with bilateral soft palate resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheotomy diff --git a/139/surgery_report.txt b/139/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..495d9a3f36cd819237cb4b04ed0f2450bf9d6d44 --- /dev/null +++ b/139/surgery_report.txt @@ -0,0 +1 @@ +Start of the operation with positioning of the patient and inspection of the oral cavity after insertion of the mouth retractor. This reveals an exophytic process of the right tonsil lobe, which completely infiltrates the soft palate, extends beyond the midline and also infiltrates the tonsil on the left side. The resection margins are then marked with the monopolar coagulation needle. Subsequently, sharp dissection starting at the soft palate, first to the right tonsil lobe. With careful hemostasis, the right tonsil is then removed in the sense of a tumor tonsillectomy with a sufficient safety margin. Here, with recurrent bleeding, difficult surgical conditions. Then dissection from the midline to the left side. Here too, tumor tonsillectomy with sufficient safety margin. The specimen is then removed in toto and sent in for pathological examination with a suture marker. This is followed by several marginal samples in the area of the anterior and posterior palatal arch and at the transition from the soft palate to the hard palate, which are then sent for frozen section diagnostics. This is followed by careful hemostasis. Inspection of the resulting defect. Virtually the entire anterior palatal arch of both tonsillar arches is missing, including the uvula and the subtotal soft palate. After the quick incisions were made, all of which were tumor-free, the decision was made to plan the defect coverage using a radial flap from the right forearm. Preoperatively, the vascular status was determined using an elliptical test and radialis Doppler. As the patient is left-handed, the decision was made to use the radial artery flap on the right side if the vascular status of the right forearm was good enough. The patient was then repositioned for tracheotomy. Transverse incision about 1 cm below the cricoid cartilage. Then dissect in layers in depth and expose the prelaryngeal neck veins and muscles. After ligating the neck veins, dissect the prevertebral musculature in the midline. After layer-by-layer dissection in depth, expose the thyroid isthmus. This is first clamped off with 2 Pean clamps and then, after severing, interrupted. Now dissect the anterior wall of the trachea. Then enter the trachea between the 2nd and 3rd cricoid cartilage. After creation of the Björk flap, epithelialization of the tracheostoma. After careful hemostasis, reintubation of the patient onto the tracheostoma. The patient is then repositioned for neck dissection, initially on the right side. To do this, make a skin incision along the sternocleidomastoid muscle. Then dissection of the front edge of the muscle and layer-by-layer dissection in depth. Expose the cervical vascular sheath. Then expose the omohyoid muscle caudally and the digaster venter posterior muscle cranially. Then locate the accessorius nerve. While preserving all outlets of the cervical vascular sheath, dissect the lateral neck preparation. Then clearing of the lateral neck triangle and the anterior neck preparation. Here too, all branches of the external carotid artery and the jugular vein can be preserved. The vagus nerve can also be visualized in its entire course in the cervical vascular sheath. After careful hemostasis and irrigation of the wound, proceed to neck dissection on the left side. The procedure is identical here. Here too, a skin incision is made along the sternocleidomastoid muscle. After exposing the anterior margin, dissection in layers in depth, where the cervical vascular sheath is then located. Then dissect caudally to the omohyoid muscle and cranially to the digaster venter posterior muscle. Here too, the lateral neck preparation is then developed while sparing the cervical vascular sheath and the vagus and accessorius nerves. Also in the lateral neck triangle, develop the neck preparation while protecting the branches of the external carotid artery and jugular vein. Exposure of the hypoglossal nerve in depth, as on the opposite side. This is also intact in its course after dissection. The anterior neck preparation is then also developed without any problems. After careful hemostasis and irrigation of the wound, insertion of a Redon drain and multi-layer skin closure. Now reposition the patient again to elevate the radial flap. First mark the flap after feeling for a good radial pulse. Then cut around the skin flap and make an S-shaped incision on the forearm. First locate the proximal part of the radial artery, just behind the exit of the interosseous artery. Then successive dissection of the artery and the accompanying veins distally. Then develop the myofascial skin flap from ulna to radial. All tendons of the fingers and wrist flexors are preserved here. The distal radial artery is then removed under pulse oximetric control. There is no drop in oxygen saturation, which is measured pulsoxymetrically on the index finger of the right hand. Then carefully and completely lift the radial artery flap while carefully stopping the bleeding. Then remove the vascular pedicle caudal to the interosseous artery. Now perforate the floor of the mouth caudal to the digaster venter posterior muscle at the posterior edge of the submandibular gland. A sufficient muscle gap is created here so that the flap pedicle can pass through easily and without crushing. At the same time, split skin is lifted from the groin on the right side to cover the defect in the forearm. Careful skin closure of the s-shaped skin incision on the forearm. Primary skin closure is made possible in the groin after skin mobilization. After insertion of a Redon drainage, this is done here with single button sutures. The split skin is then sutured to the forearm. The dressing is then applied to both the groin and the forearm. Now suture the flap pedicle. To do this, dissect the superior thyroid artery. After clamping the artery, the artery is removed. An end-to-end anastomosis is then made between the radial artery and the thyroid artery. These correspond very well to each other in terms of caliber. A regional vein is then selected in the area of the upper pole of the thyroid gland, which is placed in the area where it opens into the internal jugular vein, also after clamping. An end-to-side anastomosis is then created between the outflow vein of the flap and the internal jugular vein. The flap pedicle is then well perfused after opening the clamps. Checking the flap enorally also shows good perfusion. A sufficient pulse can be felt in the flap pedicle. Suturing of a wound flap and multi-layer wound closure of the neck dissection wound on the right side. The patient is then repositioned and the mouth retractor is inserted. Circular incision of the radial flap paramedian on the right side. The right tonsil lobe is completely covered by the flap. The remaining remnants of the anterior and posterior palatal arch are sutured together in the area of the left tonsillar lobe. The result is a beautiful reconstruction of the soft palate. Care is also taken in the dorsal part to ensure that the tubal bulges remain free during suturing and that a nasopharyngeal passage is also made possible. Once the procedure is complete, the wound is left dry. The patient is then transferred to the intensive care unit for monitoring by the anesthesia team while breathing spontaneously. \ No newline at end of file diff --git a/140/InvasionFront_CD3_block20_x5_y1_patient140_0.json b/140/InvasionFront_CD3_block20_x5_y1_patient140_0.json new file mode 100644 index 0000000000000000000000000000000000000000..90e63cfc2fa865860cba1a80e16fa0156e14ed25 --- /dev/null +++ b/140/InvasionFront_CD3_block20_x5_y1_patient140_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18312.5, + "Centroid Y µm": 3146.9, + "Num Detections": 16810, + "Num Negative": 16259, + "Num Positive": 551, + "Positive %": 3.278, + "Num Positive per mm^2": 240.82 + } +} \ No newline at end of file diff --git a/140/InvasionFront_CD3_block20_x6_y1_patient140_1.json b/140/InvasionFront_CD3_block20_x6_y1_patient140_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8642c7ce16fecc1ee7a93244fc86986b5d00f2a8 --- /dev/null +++ b/140/InvasionFront_CD3_block20_x6_y1_patient140_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20814.0, + "Centroid Y µm": 3423.2, + "Num Detections": 22818, + "Num Negative": 20447, + "Num Positive": 2371, + "Positive %": 10.39, + "Num Positive per mm^2": 882.45 + } +} \ No newline at end of file diff --git a/140/InvasionFront_CD8_block20_x5_y1_patient140_0.json b/140/InvasionFront_CD8_block20_x5_y1_patient140_0.json new file mode 100644 index 0000000000000000000000000000000000000000..156d516a928c8b40bd9c10789d5f4bf5f5f98687 --- /dev/null +++ b/140/InvasionFront_CD8_block20_x5_y1_patient140_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 2698.6, + "Num Detections": 17415, + "Num Negative": 17281, + "Num Positive": 134, + "Positive %": 0.7695, + "Num Positive per mm^2": 61.6 + } +} \ No newline at end of file diff --git a/140/InvasionFront_CD8_block20_x6_y1_patient140_1.json b/140/InvasionFront_CD8_block20_x6_y1_patient140_1.json new file mode 100644 index 0000000000000000000000000000000000000000..57d27f165825c46cfd86c988562022182eae5f9f --- /dev/null +++ b/140/InvasionFront_CD8_block20_x6_y1_patient140_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18691.9, + "Centroid Y µm": 2598.6, + "Num Detections": 22421, + "Num Negative": 20622, + "Num Positive": 1799, + "Positive %": 8.024, + "Num Positive per mm^2": 697.94 + } +} \ No newline at end of file diff --git a/140/TumorCenter_CD3_block20_x5_y1_patient140_0.json b/140/TumorCenter_CD3_block20_x5_y1_patient140_0.json new file mode 100644 index 0000000000000000000000000000000000000000..49f9c95eae3f7af799d17403952349a747808ba4 --- /dev/null +++ b/140/TumorCenter_CD3_block20_x5_y1_patient140_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16402.9, + "Centroid Y µm": 2395.7, + "Num Detections": 20349, + "Num Negative": 19448, + "Num Positive": 901, + "Positive %": 4.428, + "Num Positive per mm^2": 357.13 + } +} \ No newline at end of file diff --git a/140/TumorCenter_CD3_block20_x6_y1_patient140_1.json b/140/TumorCenter_CD3_block20_x6_y1_patient140_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d68dedd714ffbc7c240812cc8118084c0c8173c0 --- /dev/null +++ b/140/TumorCenter_CD3_block20_x6_y1_patient140_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18849.0, + "Centroid Y µm": 2274.3, + "Num Detections": 21847, + "Num Negative": 20243, + "Num Positive": 1604, + "Positive %": 7.342, + "Num Positive per mm^2": 621.14 + } +} \ No newline at end of file diff --git a/140/TumorCenter_CD8_block20_x5_y1_patient140_0.json b/140/TumorCenter_CD8_block20_x5_y1_patient140_0.json new file mode 100644 index 0000000000000000000000000000000000000000..67f125b4ae08a0b9c20c236c209bd595bc7346fe --- /dev/null +++ b/140/TumorCenter_CD8_block20_x5_y1_patient140_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15241.9, + "Centroid Y µm": 2673.6, + "Num Detections": 21919, + "Num Negative": 20769, + "Num Positive": 1150, + "Positive %": 5.247, + "Num Positive per mm^2": 450.62 + } +} \ No newline at end of file diff --git a/140/TumorCenter_CD8_block20_x6_y1_patient140_1.json b/140/TumorCenter_CD8_block20_x6_y1_patient140_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c4245217461ef867d2f4da139d2e6305b1d8fa37 --- /dev/null +++ b/140/TumorCenter_CD8_block20_x6_y1_patient140_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17690.6, + "Centroid Y µm": 2623.6, + "Num Detections": 19563, + "Num Negative": 18304, + "Num Positive": 1259, + "Positive %": 6.436, + "Num Positive per mm^2": 542.35 + } +} \ No newline at end of file diff --git a/140/history_text.txt b/140/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a423b50402e35f1cd8ffaf107e167efc2f0242fb --- /dev/null +++ b/140/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the left larynx. There is an exophytic tumor which radiates from the glottis towards the supraglottis and subglottis, extends to the anterior commissure and reaches just in front of the arytenoid cartilage. \ No newline at end of file diff --git a/140/icd_codes.txt b/140/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c2c216a48ebc4a90df3d1ecf4572116a5703e0b9 --- /dev/null +++ b/140/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Neubildung bösartig Kehlkopf sonstige[C32.8 L] \ No newline at end of file diff --git a/140/ops_codes.txt b/140/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c6d8e63f9a7dca4369448cdb9bf9863f398af12b --- /dev/null +++ b/140/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie endoskopische Laserresektion[5-302.5 ] CO2-Lasertechnik[5-985.1 ] \ No newline at end of file diff --git a/140/patient_clinical_data.json b/140/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..03b85c4018af244d93b642b167f39e60bf591e18 --- /dev/null +++ b/140/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/140/patient_pathological_data.json b/140/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..13a66fa535fff3bbdd59f30baacc82f66205cf61 --- /dev/null +++ b/140/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "140", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/140/surgery_description.txt b/140/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8c9ef5ba23f3e3056aecf74a9a536a0fec00c9a4 --- /dev/null +++ b/140/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection, CO2 laser diff --git a/140/surgery_report.txt b/140/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..494b615558315152cee268bbe9f83acc463ea7fa --- /dev/null +++ b/140/surgery_report.txt @@ -0,0 +1 @@ +Pharyngoscopy and laryngoscopy: Findings are confirmed. Findings on CT correlated. Now entering with the Kleinsasser tube size B and adjusting the tumor. Tumor is now resected successively with a safety margin of between 0.5 and just under 1 cm. Laterally, the resection extends to the cartilage, anteriorly also dorsally to the arytenoid cartilage, which is resected slightly in the interlaryngeal area. Caudally, the resection extends to the cricoid cartilage. The tumor is removed and resected microscopically with a safety margin. The tumor is suture-marked. Due to the fact that the anterior and posterior margins are somewhat narrower, a glottic, subglottic and supraglottic margin sample is taken from the area of the anterior commissure and the adjacent soft tissue. Also marginal sample dorsally in the area of the arytenoid cartilage and the arytenoid fold transition. In the frozen section, all samples are tumor-free or the edges of the tumor are tumor-free. So R0 situation. Hemostasis follows. In the anterior region, the transverse artery in the area of the conus elasticus had to be bipolized during the resection; this will be repeated. In the dorsal area, the inferior laryngeal artery was treated with clips. No more bleeding here. Most careful hemostasis. No evidence of bleeding on final inspection. Exposure of the cartilage in the area of the anterior commissure and on the left in the entire area. Patient therefore received Sobelin 600 mg i.v. Please continue antibiotics for one week. Patient goes to the recovery ward for monitoring, should remain there for a prolonged period and may be admitted to the intensive care unit for one night. It is essential to plan a follow-up endoscopy in 8-12 weeks. \ No newline at end of file diff --git a/141/InvasionFront_CD3_block11_x1_y5_patient141_0.json b/141/InvasionFront_CD3_block11_x1_y5_patient141_0.json new file mode 100644 index 0000000000000000000000000000000000000000..48c391fb051be3e3d0ee4995e11b614bacfc04fb --- /dev/null +++ b/141/InvasionFront_CD3_block11_x1_y5_patient141_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3173.3, + "Centroid Y µm": 12293.5, + "Num Detections": 20349, + "Num Negative": 17172, + "Num Positive": 3177, + "Positive %": 15.61, + "Num Positive per mm^2": 1371.4 + } +} \ No newline at end of file diff --git a/141/InvasionFront_CD3_block11_x2_y5_patient141_1.json b/141/InvasionFront_CD3_block11_x2_y5_patient141_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8dac240281d2b0b70079a447d7a0a2142fe4d20a --- /dev/null +++ b/141/InvasionFront_CD3_block11_x2_y5_patient141_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 12218.5, + "Num Detections": 20366, + "Num Negative": 18527, + "Num Positive": 1839, + "Positive %": 9.03, + "Num Positive per mm^2": 789.59 + } +} \ No newline at end of file diff --git a/141/InvasionFront_CD8_block11_x1_y5_patient141_0.json b/141/InvasionFront_CD8_block11_x1_y5_patient141_0.json new file mode 100644 index 0000000000000000000000000000000000000000..83bca4d42f5854874410fcd0afb71c76f59f740e --- /dev/null +++ b/141/InvasionFront_CD8_block11_x1_y5_patient141_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 23137.7, + "Num Detections": 20347, + "Num Negative": 19094, + "Num Positive": 1253, + "Positive %": 6.158, + "Num Positive per mm^2": 557.41 + } +} \ No newline at end of file diff --git a/141/InvasionFront_CD8_block11_x2_y5_patient141_1.json b/141/InvasionFront_CD8_block11_x2_y5_patient141_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3ca18e69e570e4b1ea19b774dbfe3eee882ae05 --- /dev/null +++ b/141/InvasionFront_CD8_block11_x2_y5_patient141_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8973.6, + "Centroid Y µm": 22910.5, + "Num Detections": 18835, + "Num Negative": 17870, + "Num Positive": 965, + "Positive %": 5.123, + "Num Positive per mm^2": 436.69 + } +} \ No newline at end of file diff --git a/141/TumorCenter_CD3_block11_x1_y5_patient141_0.json b/141/TumorCenter_CD3_block11_x1_y5_patient141_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d6f3371cabe683116f99ab5dbe2786922be18c0 --- /dev/null +++ b/141/TumorCenter_CD3_block11_x1_y5_patient141_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6996.3, + "Centroid Y µm": 11918.7, + "Num Detections": 18189, + "Num Negative": 15500, + "Num Positive": 2689, + "Positive %": 14.78, + "Num Positive per mm^2": 1235.9 + } +} \ No newline at end of file diff --git a/141/TumorCenter_CD3_block11_x2_y5_patient141_1.json b/141/TumorCenter_CD3_block11_x2_y5_patient141_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7809b1ea0f2661392efdac2ed14e7df6b2152197 --- /dev/null +++ b/141/TumorCenter_CD3_block11_x2_y5_patient141_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9594.9, + "Centroid Y µm": 12043.6, + "Num Detections": 18339, + "Num Negative": 15294, + "Num Positive": 3045, + "Positive %": 16.6, + "Num Positive per mm^2": 1381.4 + } +} \ No newline at end of file diff --git a/141/TumorCenter_CD8_block11_x1_y5_patient141_0.json b/141/TumorCenter_CD8_block11_x1_y5_patient141_0.json new file mode 100644 index 0000000000000000000000000000000000000000..01e352788f391389558a770340710beaabeb8c74 --- /dev/null +++ b/141/TumorCenter_CD8_block11_x1_y5_patient141_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4372.7, + "Centroid Y µm": 11793.8, + "Num Detections": 16738, + "Num Negative": 13853, + "Num Positive": 2885, + "Positive %": 17.24, + "Num Positive per mm^2": 1286.2 + } +} \ No newline at end of file diff --git a/141/TumorCenter_CD8_block11_x2_y5_patient141_1.json b/141/TumorCenter_CD8_block11_x2_y5_patient141_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1de093d2165f659b0d6ce537f8a388358a4cc1ed --- /dev/null +++ b/141/TumorCenter_CD8_block11_x2_y5_patient141_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6996.3, + "Centroid Y µm": 11993.6, + "Num Detections": 18586, + "Num Negative": 15123, + "Num Positive": 3463, + "Positive %": 18.63, + "Num Positive per mm^2": 1542.1 + } +} \ No newline at end of file diff --git a/141/history_text.txt b/141/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/141/icd_codes.txt b/141/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/141/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/141/ops_codes.txt b/141/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0645fbc068886c98def59f2870c6446f222026d9 --- /dev/null +++ b/141/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 L] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal: 5 Regionen[5-403.11 R] Radikale Resektion des Pharynx [Pharyngektomie]: Transoral: Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Reoperation[5-983 ] Mikrochirurgische Technik[5-984 ] Entnahme eines myokutanen Lappens am Unterarm mit mikrovaskulärer Anastomosierung[5-858.23 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] \ No newline at end of file diff --git a/141/patient_clinical_data.json b/141/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..15fe3958f8c90a5506e1275b5e70b1662d122ce2 --- /dev/null +++ b/141/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 8, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/141/patient_pathological_data.json b/141/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..93685a4a99ff7a2d6a7700ddaa36eca7f181beae --- /dev/null +++ b/141/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "141", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 7.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/141/surgery_description.txt b/141/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..dfff9694751473640bda6c72545f42edc8d99abb --- /dev/null +++ b/141/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Partial pharyngectomy, Bilateral neck dissection, Reconstruction, Free flap (Radial), Tracheostomy, Pharyngoscopy diff --git a/141/surgery_report.txt b/141/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7989df89538f1574a360dc903afc4cb7e02fd615 --- /dev/null +++ b/141/surgery_report.txt @@ -0,0 +1 @@ +At the beginning of the operation, after intubation and induction of anesthesia, pharyngoscopy is performed to re-inspect the findings: Tumor growth starting from the tonsil with spread to the left soft palate to parauvular, but not involving the hard palate. The tumor growth also extends to the base of the tongue and covers approx. 1/4 to 1/3 of the base of the tongue on the left. Caudally, the tumor extends into the vallecula and just above the entrance of the piriform recess on the left side. Enorally, the tumor is first dissected in the area of the soft palate up to the transition to the base of the tongue. Due to the further deep extension and the poor visibility, it was decided to approach the further tumor resection via a lateral pharyngotomy, after appropriate left-sided neck dissection. To do this, first make a skin incision along the front edge of the sternocleidomastoid muscle. Cut through the platysma and dissect the vascular nerve sheath. Due to the extensive metastasis (cN2b) with infiltration of the sternocleidomastoid muscle, accessorius nerve and the cranial part, particularly in the area where the facial vein leaves the internal jugular vein, as well as the infiltration of the digastric muscle and individual branches of the external carotid artery, an extended radical neck dissection is performed. This is followed by dissection of the vascular nerve sheath in the caudal part, identification of the vagus nerve and the common carotid artery as well as the internal jugular vein. The internal jugular vein is set off on the left side above this after the vein leaves the thyroid gland. The sternocleidomastoid muscle is also removed caudally and cranially in the area of the mastoid. Bypass the digastric venter muscle posteriorly and remove the muscle. The internal jugular vein is also carefully exposed and ligated and cut at its entry into the jugular foramen. The tumor infiltrates the sympathetic trunk, so to speak, and this must therefore also be severed. The tumor cone can be removed directly at the level of the intervertebral foramen. The extensive metastasis can be resected macroscopically in toto, taking the accessorius nerve and cranial parts of the plexus with it. The branches of the facial artery and lingual artery are ligated and severed at the carotid artery. The entire course of the hypoglossal nerve is dissected and can be preserved. The vagus nerve is also dissected and can be preserved. Level Ib is also completely removed during the operation, taking the submandibular gland with it. The previously resected wound bed is now reached from the cervical side. The base of the tongue can be grasped with the tumor and can now also be bypassed in the middle and caudal part with excellent visibility. The entire specimen is then sent for histopathological examination. As there is carcinoma in situ between the pharyngeal wall and the entrance to the piriform recess, a thorough resection is carried out here again and a final marginal sample is taken. This is followed by the neck dissection on the right side: for this purpose, a skin incision is made along the front edge of the sternocleidomastoid muscle and the vascular nerve sheath is dissected. The external jugular vein and auricular nerve are preserved. Dissection along the omohyoid muscle to the hyoid bone and along the posterior digastric venter muscle to the laterobase. Lifting of neck block II, III and IV while preserving all nerve and vascular structures. Finally, elevation of level V with protection of the accessorius nerve and the cervical plexus. There are no macroscopically conspicuous lymph nodes here. Insertion of a 10 Redon drain, subcutaneous sutures and single button skin suture. Parallel to the right-sided neck dissection, the radialis graft is lifted from the left forearm. For this purpose, an individually shaped radialis skin graft is drawn in according to the defect and after appropriate measurement and lifted accordingly, using a skin monitor. The graft is lifted in a typical manner and the superficial ramus of the radial nerve is preserved. After previous lateral radial and ulnar dissection, the radial artery graft is now lifted subfascially while preserving the peritendineum from distal to proximal up to the ulnar bend. Dissection of the radial artery up to the confluence with the ulnar artery and the venae comitantes up to the confluence with a common vessel. Opening of the previously placed tourniquet and hemostasis. Removal of the radial artery graft and insertion of the radial artery graft from the outside to the inside and subsequent incision and reconstruction of the soft palate as well as the lateral pharyngeal wall and the base of the tongue with the preformed flap. The cranial part is incorporated enorally, the caudal parts via the pharyngotomy. The graft fits in without tension and is the ideal size. At the same time, full-thickness skin is lifted from the right groin. Careful hemostasis. Primary wound closure. An 8-gauge Redon drain is inserted into the right groin. The full-thickness skin is carefully thinned out and the lifting defect on the left forearm is partly covered primarily and partly with full-thickness skin. After appropriate incision of the full-thickness skin, application of a VAC pump, which should be left in place for 7 days. Application of a Cramer splint. Deposition of hand and forearm. Prior to this, a tracheostoma was created through a skin incision in the area of the jugulum. Dissection of the subcutaneous tissue and the infrahyoid musculature. Exposure of the thyroid isthmus, cutting through it. Exposure of the anterior wall of the trachea and creation of a caudally pedicled Björk flap. Careful suturing of the trachea to the skin. Re-intubation. Suturing of the cannula. After successful microvascular anastomization by end-to-end anastomosis of the flap artery with the superior thyroid artery (8/0 nylon) and the flap vein with the previously described thyroid vein outlet from the internal jugular vein (coupler 2,5 mm) and control of excellent arterial and venous flow as well as good coloration of the graft, a Redon drain is now inserted and the Redon drain is fixed in place with loops to prevent aspiration of the flap pedicle. After ensuring that the wound bed is dry, subcutaneous sutures and skin sutures are applied. Monitor the graft in the typical manner and avoid any dressings or bandages in the neck area. Keep the upper body elevated and the head straight. If there are any problems with the transplant, please inform the surgeon at all times. \ No newline at end of file diff --git a/142/InvasionFront_CD3_block8_x1_y11_patient142_0.json b/142/InvasionFront_CD3_block8_x1_y11_patient142_0.json new file mode 100644 index 0000000000000000000000000000000000000000..918bba205a3b9d7749e847553e99719e8163514a --- /dev/null +++ b/142/InvasionFront_CD3_block8_x1_y11_patient142_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4010.4, + "Centroid Y µm": 38104.8, + "Num Detections": 15752, + "Num Negative": 15373, + "Num Positive": 379, + "Positive %": 2.406, + "Num Positive per mm^2": 170.8 + } +} \ No newline at end of file diff --git a/142/InvasionFront_CD3_block8_x2_y11_patient142_1.json b/142/InvasionFront_CD3_block8_x2_y11_patient142_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a48240bc2a800054e24108eb9a3156ee8c58cc04 --- /dev/null +++ b/142/InvasionFront_CD3_block8_x2_y11_patient142_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6534.0, + "Centroid Y µm": 38004.9, + "Num Detections": 17801, + "Num Negative": 16962, + "Num Positive": 839, + "Positive %": 4.713, + "Num Positive per mm^2": 372.12 + } +} \ No newline at end of file diff --git a/142/InvasionFront_CD8_block8_x1_y11_patient142_0.json b/142/InvasionFront_CD8_block8_x1_y11_patient142_0.json new file mode 100644 index 0000000000000000000000000000000000000000..07c94f8a89309a965f9735bf1988d506e16f1f8e --- /dev/null +++ b/142/InvasionFront_CD8_block8_x1_y11_patient142_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3223.3, + "Centroid Y µm": 27635.4, + "Num Detections": 16196, + "Num Negative": 16030, + "Num Positive": 166, + "Positive %": 1.025, + "Num Positive per mm^2": 78.45 + } +} \ No newline at end of file diff --git a/142/InvasionFront_CD8_block8_x2_y11_patient142_1.json b/142/InvasionFront_CD8_block8_x2_y11_patient142_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c1e928f319dd803220824354e518e3d8e6b4c90 --- /dev/null +++ b/142/InvasionFront_CD8_block8_x2_y11_patient142_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5697.0, + "Centroid Y µm": 27835.3, + "Num Detections": 11670, + "Num Negative": 11217, + "Num Positive": 453, + "Positive %": 3.882, + "Num Positive per mm^2": 293.78 + } +} \ No newline at end of file diff --git a/142/TumorCenter_CD3_block8_x1_y11_patient142_0.json b/142/TumorCenter_CD3_block8_x1_y11_patient142_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6793c16343c75bad87535cdc528c1fa3c866cfcb --- /dev/null +++ b/142/TumorCenter_CD3_block8_x1_y11_patient142_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5992.4, + "Centroid Y µm": 29172.1, + "Num Detections": 15794, + "Num Negative": 15204, + "Num Positive": 590, + "Positive %": 3.736, + "Num Positive per mm^2": 278.8 + } +} \ No newline at end of file diff --git a/142/TumorCenter_CD3_block8_x2_y11_patient142_1.json b/142/TumorCenter_CD3_block8_x2_y11_patient142_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9ae5e16e2d45530a3f067409ccef2a13ba19235 --- /dev/null +++ b/142/TumorCenter_CD3_block8_x2_y11_patient142_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8395.6, + "Centroid Y µm": 29109.6, + "Num Detections": 21818, + "Num Negative": 21127, + "Num Positive": 691, + "Positive %": 3.167, + "Num Positive per mm^2": 290.21 + } +} \ No newline at end of file diff --git a/142/TumorCenter_CD8_block8_x1_y11_patient142_0.json b/142/TumorCenter_CD8_block8_x1_y11_patient142_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d8c48af166292df546c415686a78fd343293dfa6 --- /dev/null +++ b/142/TumorCenter_CD8_block8_x1_y11_patient142_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5172.3, + "Centroid Y µm": 28185.1, + "Num Detections": 17528, + "Num Negative": 17471, + "Num Positive": 57, + "Positive %": 0.3252, + "Num Positive per mm^2": 25.68 + } +} \ No newline at end of file diff --git a/142/TumorCenter_CD8_block8_x2_y11_patient142_1.json b/142/TumorCenter_CD8_block8_x2_y11_patient142_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c5ae88ec1fbc653abb2ed45efce40c4df8aff434 --- /dev/null +++ b/142/TumorCenter_CD8_block8_x2_y11_patient142_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7596.0, + "Centroid Y µm": 28060.1, + "Num Detections": 23191, + "Num Negative": 23106, + "Num Positive": 85, + "Positive %": 0.3665, + "Num Positive per mm^2": 35.05 + } +} \ No newline at end of file diff --git a/142/history_text.txt b/142/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..632e1998c0da61a0d26b7e450ed14a884625284a --- /dev/null +++ b/142/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT3 oropharyngeal carcinoma on the left. The above-mentioned surgery was therefore indicated. \ No newline at end of file diff --git a/142/icd_codes.txt b/142/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa6097eacf18ae8aea8260bca82cce6b0a31ad0c --- /dev/null +++ b/142/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 L] \ No newline at end of file diff --git a/142/ops_codes.txt b/142/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0df80d0eb60a028527ff255058891c9c56c7a0b9 --- /dev/null +++ b/142/ops_codes.txt @@ -0,0 +1 @@ +Radikale Resektion des Pharynx durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Temporäre Tracheotomie[5-311.0 ] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Entnahme von Spalthaut am Oberschenkel[5-901.0e R] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Weichgaumenteilresektion[5-272.1 ] \ No newline at end of file diff --git a/142/patient_clinical_data.json b/142/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d5217a9c2472fea9f3fd1117872a1064eabb1508 --- /dev/null +++ b/142/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 60, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/142/patient_pathological_data.json b/142/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..83a4936c576e39aece7f3d88138b2e738527d92e --- /dev/null +++ b/142/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "142", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/142/surgery_description.txt b/142/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fe15d5deb092f82fb52ffc99e7c0cc4a3fa71034 --- /dev/null +++ b/142/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheotomy diff --git a/142/surgery_report.txt b/142/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..72a16e335da36ab73d3513df4b07e36f596beb49 --- /dev/null +++ b/142/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesiologist. After reclination of the head, pharyngoscopy and laryngoscopy again: The described tumor is seen, which starts next to the uvula on the left, extends over the palatal arch and the tonsillar lobe to the base of the tongue. The tumor grows in the area of the cranial oropharyngeal side wall ulcerating in depth. Therefore, flap coverage is also indicated according to the CT findings. PEG placement is performed first: insertion of the flexible esophagoscope. Push through into the stomach. After creating the diaphanoscopy, insertion of a 15 mm abdominal wall tube in a typical manner without complications. Fixation of the abdominal wall in the typical manner. Then repositioning of the patient. Skin disinfection, sterile draping of all relevant surgical areas. Start with the neck dissection on the left: Skin incision curved in a typical manner. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle, digastric muscle. Exposure of the submandibular gland. Exposure and preservation of the common carotid artery, internal/external carotid artery, internal jugular vein, vagus nerve, accessorius nerve, hypoglossal nerve. Displacement, neurolysis and re-embedding of the vagus nerve, accessorius nerve and hypoglossal nerve. Also visualization of the branches of the cervical plexus. Development of the posterior neck preparation and later also the anterior neck preparation. This results in the removal of levels II-V. All branches of the cervical plexus were exposed and preserved. Neck dissection on the right: skin incision as on the opposite side. Exposure of all structures as on the opposite side. Displacement, neurolysis and re-embedding of the vagus nerve, accessorius nerve and hypoglossal nerve. This results in a level II-IV neck dissection and smaller parts of V. All structures are exposed and preserved as on the opposite side. Tracheostoma creation: Small Kocher's cross-section. Dissection through the subcutaneous tissue to the infrahyoid musculature. Spreading of these. Exposure of the thyroid isthmus. Undercutting, clamping, severing and ligation using puncture ligatures. Exposure of the trachea. Preparation of a small wide-pedicled Björk flap. Epithelization of the same in a typical manner. Insertion of a laryngectomy tube. Tumor resection from the transoral and trancervical side, initially from the left side of the neck dissection. Dissection of the external carotid artery, internal carotid artery, vagus nerve, hypoglossal nerve, accessorius nerve and internal jugular vein as well as the superior ganglion from the pharyngeal wall. Nerve vessels are dissected from the pharyngeal tube up to the base of the skull. No tumor infiltrates visible here. The submandibular gland is also extirpated. The lingual nerve is exposed and preserved. Displacement, neurolysis and re-embedding of the same. The digastric muscle is also resected. All important vessels and nerve structures are then looped using Vesselloops and pulled to the side. Transorally, the tumor is incised on all sides with a safety margin of at least 1.5 cm. This results in the removal of the entire pharyngeal wall including the attached soft tissue up to the level of the piriform sinus entrance. Resection extends inwards to the base of the tongue. Approximately 20% of this is resected. The posterior pharyngeal wall is partially resected. The tumor specimen is thread-marked and sent for frozen section diagnostics. Similarly, marginal samples are taken from the palatal arch, from the pharyngeal wall medially, from the transition from the posterior palatal arch to the tonsil, from the lateral in the form of the uvula and a soft tissue marginal sample from the cranial-basal side. In the frozen section preparation, taking into account the marginal samples in healthy tissue. Unclear situation at the transition from palatal arch to medial pharyngeal wall. Therefore, another cranial-medial margin sample was taken from the pharyngeal wall at the junction of the tonsillar lobe and palatal arch. No tumor infiltrates in the frozen section here either. Thus a definitive R0 situation. The result is a defect on the palatal arch extending beyond the uvula, posterior pharyngeal wall, lateral pharyngeal wall up to the entrance of the piriform sinus and the base of the tongue and vallecula up to the epiglottis. A radial lobe is measured in terms of length, width and three-dimensional shape. The radial lobe is then elevated from the left forearm: Mark the radialis flap, which reaches 13 cm in length and 8 cm in maximum width. First lift the flap from the ulnar side. Then extend the incision into the crook of the elbow. Exposure of the vascular pedicle, exposure of the superficial vascular system. Then lift the flap from the radial side. Deposition of the flap distally and ligation of the radial artery cranially and caudally using 4.0 Prolene sutures. The flap is then lifted subfascially along its pedicle, including the superficial venous system. Outgoing vessels are bipolized or treated with clips, larger ones are ligated. Cranial view of the connection between the superficial and deep venous system. There is only a rudimentary venous outflow via the radial vein, which is divided into smaller vessels. These are clipped. The interosseous artery is very small and is clipped. The flap is removed at the brachial artery and two larger branches from the cephalic vein. The veins are ligated. The artery is supplied with a 6.0 Vascufil suture. Saturation during the elevation is always 100%, clinically no abnormalities. The flap is flushed with heparin. Subsequent insertion of the flap: insertion into the defect. Successive incorporation of the flap into the defect using 3.0 Vicryl single-button sutures, which is successful without tension. Flap suturing partially with sutures in place. Subsequent arterial anastomosis. The superior thyroid artery is selected. After conditioning the vessels, suture with 8.0 Ethilon single-button sutures. After opening the clamp, good arterial flow, good venous return. Conditioning of the two outlets of the cephalic vein. One outlet is anastomosed with an outlet from the facial vein. Anastomosis is performed after conditioning the vessels with a 2.5 mm coupler. The other outlet is then anastomosed with an outlet from the V. thyroidea media after conditioning the vessel ends using a 2.5 mm coupler. Again, after opening the vessels, good venous return, positive smear phenomenon. This is followed by extensive irrigation of the neck wounds on both sides and careful hemostasis. Wound closure in layers with insertion of a Redon drain on both sides. Pressure dressing on both sides. Covering the forearm defect on the left: For this purpose, a 0.7-0.8 mm thick split-thickness skin graft is obtained from the thigh according to size. This is successively incorporated into the forearm skin defect. Application of a hydrogel-Mepilex dressing. Application of a loose compress dressing, wrapping with absorbent cotton. The arm is fixed in a Kramer splint in a functional position and wrapped with an elastic bandage. The arm was applied before the anastomosis suture. Arm always well perfused, saturation 100%. Finally, removal of the laryngectomy tube. Insertion of an 8 mm tracheostomy tube, which is fixed with sutures. Completion of the procedure without complications. The patient is intubated and ventilated and transferred to the intensive care unit for monitoring. Final consultation with the anesthesia department. Please continue heparin perfusor 500 I.U./hour as started intraoperatively, also postoperatively for 5 days. Check the blood circulation of the flap clinically and via suture marking on the left side of the neck in a typical manner according to the plan. Please continue antibiotics as started intraoperatively with Unacid 3 g for 2-3 days. Feeding for approx. 10 days via the inserted PEG tube, then gruel and, if necessary, diet build-up. Determine adjuvant therapy according to the final histological findings in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/143/InvasionFront_CD3_block12_x5_y3_patient143_0.json b/143/InvasionFront_CD3_block12_x5_y3_patient143_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7560bebbf25e8f11a2a0502aca2b4a17baee6650 --- /dev/null +++ b/143/InvasionFront_CD3_block12_x5_y3_patient143_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17190.9, + "Centroid Y µm": 12468.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/143/InvasionFront_CD3_block12_x6_y3_patient143_1.json b/143/InvasionFront_CD3_block12_x6_y3_patient143_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0298f722ec61a99313035bac9cacaa7375bdde3a --- /dev/null +++ b/143/InvasionFront_CD3_block12_x6_y3_patient143_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19664.6, + "Centroid Y µm": 12693.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/143/InvasionFront_CD8_block12_x5_y3_patient143_0.json b/143/InvasionFront_CD8_block12_x5_y3_patient143_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7154edb7a148e7a0491be6b45f6d077435a11bb2 --- /dev/null +++ b/143/InvasionFront_CD8_block12_x5_y3_patient143_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17041.0, + "Centroid Y µm": 10794.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/143/InvasionFront_CD8_block12_x6_y3_patient143_1.json b/143/InvasionFront_CD8_block12_x6_y3_patient143_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9058107ea3b622b6b41dff4c1307f5f32b02dfa9 --- /dev/null +++ b/143/InvasionFront_CD8_block12_x6_y3_patient143_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19564.6, + "Centroid Y µm": 10719.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/143/TumorCenter_CD3_block12_x5_y3_patient143_0.json b/143/TumorCenter_CD3_block12_x5_y3_patient143_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b7a4edc791fe5d2044f18f9189e2554b48259514 --- /dev/null +++ b/143/TumorCenter_CD3_block12_x5_y3_patient143_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15841.6, + "Centroid Y µm": 7521.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/143/TumorCenter_CD3_block12_x6_y3_patient143_1.json b/143/TumorCenter_CD3_block12_x6_y3_patient143_1.json new file mode 100644 index 0000000000000000000000000000000000000000..31713b1732149a0fba85fa3165c8553e2c4ffddd --- /dev/null +++ b/143/TumorCenter_CD3_block12_x6_y3_patient143_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 7096.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/143/TumorCenter_CD8_block12_x5_y3_patient143_0.json b/143/TumorCenter_CD8_block12_x5_y3_patient143_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c7986d2d00fc42608343ab1b0909e5b6a1fa412a --- /dev/null +++ b/143/TumorCenter_CD8_block12_x5_y3_patient143_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19473.5, + "Centroid Y µm": 17054.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/143/TumorCenter_CD8_block12_x6_y3_patient143_1.json b/143/TumorCenter_CD8_block12_x6_y3_patient143_1.json new file mode 100644 index 0000000000000000000000000000000000000000..969aab4d750340cc9894da7a8751803c0a6c5799 --- /dev/null +++ b/143/TumorCenter_CD8_block12_x6_y3_patient143_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21869.7, + "Centroid Y µm": 17120.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/143/history_text.txt b/143/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9f18ea0fcb27e54dc27765d0c4f72f1e6dbfb1ec --- /dev/null +++ b/143/history_text.txt @@ -0,0 +1 @@ +The patient was diagnosed with cT4a cN2a G3 hypopharyngeal carcinoma on the left during a panendoscopy on <2011>, and our interdisciplinary tumor conference recommended primary surgical treatment. CT showed clear herniation into the thyroid cartilage on the left side without complete penetration. \ No newline at end of file diff --git a/143/icd_codes.txt b/143/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8942df050249e3880166bd6eaf35efe4c40f2c9 --- /dev/null +++ b/143/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] \ No newline at end of file diff --git a/143/ops_codes.txt b/143/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d662c1043c89c2662760fcd3e93e2c7f6b7fc84b --- /dev/null +++ b/143/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/143/patient_clinical_data.json b/143/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7a1464efb4f369c1fd465117cc97aefe354c5c91 --- /dev/null +++ b/143/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 42, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/143/patient_pathological_data.json b/143/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5e4ca8dc9d7275e9d91645bcc194e93b5bed9905 --- /dev/null +++ b/143/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "143", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 51, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 50.0 +} \ No newline at end of file diff --git a/143/surgery_description.txt b/143/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9b57f1c9b808c9d1cdf777eb0780d37739c97823 --- /dev/null +++ b/143/surgery_description.txt @@ -0,0 +1 @@ +Partial pharyngectomy with laryngectomy, Bilateral neck dissection, Provox Prosthesis, Endoscopy diff --git a/143/surgery_report.txt b/143/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..97b7ea08f01f07ec6f09ce1827eb0c35583fc6ea --- /dev/null +++ b/143/surgery_report.txt @@ -0,0 +1 @@ +After bronchoscopic intubation of the patient, the anesthesiology colleagues first perform a pharyngo-laryngoscopy to determine the extent of the mass again. This revealed the aforementioned mass in the area of the left piriform sinus, the right piriform sinus anterior and lateral wall extending into the tip of the piriform sinus and infiltrating from here towards the arytenoid and the left hemilarynx. Pronounced edema also in the area of the aryepiglottic fold. The left vocal fold is edematous. This confirms the indication for laryngectomy. Due to the circumscribed extension in the area of the hypoharynx and piriform sinus, most likely with primary closure. Now reposition the patient with xylocaine and adrenaline. Skin incision to lift an apron flap. Cut through the skin and subcutaneous tissue. Separation of the platysma. Creation of a platysma flap on both sides and lifting of the apron flap. Suturing of the flap. Exposure of the external jugular veins on both sides, these remain intact on both sides. An anterior branch of the external jugular vein is ligated on the left side. Now first perform the neck dissection. Start with the left side. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland. Resection of the caudal part of the capsule, exposure of the entire length of the digastric muscle. Release of the anterior neck preparation with preservation of the superior thyroid artery and resection of the cervical artery. Exposure and preservation of the hypoglossal nerve. A metastasis measuring approx. 5 x 3 without peronodal or infiltrative growth and adherent to the sternocleidomastoid muscle can now be seen on the cervical vascular sheath in the area of the jugulo-facial angle. Dissection of the internal jugular vein after previous visualization of the accessorius nerve. Operation on the internal jugular vein, which, like the facial vein, is very weakly developed on this side, is coagulated and removed. Complete dissection of the vein. Release of the accessorius triangle, lateral exposure of the internal jugular vein with careful protection of the common carotid artery and vagus nerve. Include the cervical artery here. Now carefully evacuate levels Va and Vb while carefully preserving the plexus branches without evidence of lymphatic leakage. Careful inspection. Removal of the neck resectate en bloc and, if dry and completely evacuated, insertion of a moist abdominal drape and turning to the opposite side. The procedure is basically exactly the same here. Exposure of the sternocleidomastoid muscle, omohyoid muscle, exposure of the submandibular gland with resection of the caudal part of the capsule. Exposure of the digastric muscle. Dissection of the anterior neck preparation with preservation of the superior thyroid artery and the hypoglossal nerve and with removal of the cervical artery. Dissection of the internal jugular vein, here a suspicious lymph node change measuring approx. 2 cm can be seen in the area of the jugulofacial angle, this is coarse on palpation, therefore clinically V.a. cN2c neck status. Visualization of the accessorius nerve. Complete exposure of the internal jugular vein. The facial vein is exposed and remains intact. Now clearing of the accessorius triangle and subsequent removal of level Va and level Vb. Finally, also dry conditions. No evidence of lymph leakage. Now turn to the laryngeal surgery. Exposure of the hyoid, detachment in front of the infrahyoid muscles, skeletonization of the larynx, exposure of the cricoid cartilage and the anterior surface of the trachea. Dissection of the thyroid isthmus and exposure of the anterior surface of the trachea on both sides. On the left side, detachment of the infrahyoid musculature, but here leaving a layer on the laryngeal skeleton in the case of thyroid cartilage infiltration. Now incision of the subperichondrium on the right side, detachment of the perichondrium on the inner surface while carefully preserving the pharyngeal mucosa. Now enter with the Mc Ivor spatula. Expose the vallecula. Performing the pharyngotomy in the area of the right vallecula. Widening of the pharyngotomy. Snaring of the epiglottis. Incision along the aryepiglottic fold towards the postcricoid region. Now complete overview of the tumor. Tumor extension as described above with deep ulcerated tumor in the area of the left piriform sinus well defined. Regular mucosal conditions in the marginal area. Somewhat granular mucosal conditions in the area of the postcricoid region, therefore choose a larger safety distance and demonstration to , who recommends a sparing resection in the area of the postcricoid region, otherwise coordination of the procedure. Further resection of the tumor on all sides with at least a 1.5 cm safety margin on all sides. Lateral to the tumor, removal of a soft tissue mantle, palpatorily no deep growth towards the soft tissues of the neck. In the meantime, tracheotomy has already been performed. Initially a visual tracheotomy. Re-intubation onto an LE tube. Now resection caudal removal of the tumor approx. 2-3 cm above the esophageal inlet. Removal of the trachea after previous snaring and removal of the resectate. The specimen now shows macroscopic removal in toto on all sides. ............. Hypopharyngeal carcinoma but now cover the tumor. Take contiguous mucosal samples over the entire resection area. These are thread-marked and later assessed in rapid diagnostics as completely free of tumor and dysplasia. A caudally tapering strip of mucosa is now visible, but with at least 4-5 cm of residual mucosa caudally to cranially. It was therefore decided to perform a primary reconstruction with the local mucosa. After palpation, perform a myotomy in the area of the upper oesophageal sphincter and insert an 8 mm provost prosthesis using the usual pull-through method with puncture about 1 cm caudal to the future tracheostoma edge and insertion of a nasogastric tube and meticulous mucosal suture with 3.0 Vicryl while inverting the .................... Caudal pharyngeal suture area and base of tongue on both sides, thin pharyngeal mucosa circumscribed on the right side, this is later reinforced with pharyngeal musculature with an overall well-preserved and strong tube. Now in the pharyngeal muscles and inversion of the submucosal pharyngeal suture. Finally, caudal suturing of the pharyngeal tube with the thyroid flap and final suturing of the infrahyoid muscles to the base of the tongue and over the pharyngeal sutures. The tracheostoma was sutured in place beforehand, with a second skin incision and circular suturing of the trachea. Finally, stable tracheostoma. Final wound inspection. Circumscribed meticulous hemostasis with generally dry wound conditions. Irrigation with Ringer's solution and, if the wound is dry, insertion of a 10 mm Redon drain and careful two-layer wound closure. Finally, reintubation to a 10-gauge tracheoflex cannula and completion of the procedure without any indication of complications. The patient received intraoperative intravenous antibiotics and Unacid 1.5 g; please continue this antibiotic treatment for 3 days postoperatively. The X-ray emesis was performed on the 8th postoperative day. Conclusion: Intraoperative R0 resected cT4a cN2c G3 hypopharyngeal carcinoma on the left. After receiving the definitive histology, presentation at our interdisciplinary tumor conference to plan adjuvant therapy. \ No newline at end of file diff --git a/144/InvasionFront_CD3_block21_x1_y12_patient144_0.json b/144/InvasionFront_CD3_block21_x1_y12_patient144_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3da152bf0707309a14751f2cdef5f98e2f77b3a4 --- /dev/null +++ b/144/InvasionFront_CD3_block21_x1_y12_patient144_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5097.3, + "Centroid Y µm": 40028.8, + "Num Detections": 19544, + "Num Negative": 18820, + "Num Positive": 724, + "Positive %": 3.704, + "Num Positive per mm^2": 325.4 + } +} \ No newline at end of file diff --git a/144/InvasionFront_CD3_block21_x2_y12_patient144_1.json b/144/InvasionFront_CD3_block21_x2_y12_patient144_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8fa5a3129637a42f54d5a1a1ea680fb0729e9dc3 --- /dev/null +++ b/144/InvasionFront_CD3_block21_x2_y12_patient144_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7546.0, + "Centroid Y µm": 40278.7, + "Num Detections": 16608, + "Num Negative": 16162, + "Num Positive": 446, + "Positive %": 2.685, + "Num Positive per mm^2": 226.16 + } +} \ No newline at end of file diff --git a/144/InvasionFront_CD8_block21_x1_y12_patient144_0.json b/144/InvasionFront_CD8_block21_x1_y12_patient144_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a066f96d67c6b02e958274b4943953313aa2e047 --- /dev/null +++ b/144/InvasionFront_CD8_block21_x1_y12_patient144_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3498.1, + "Centroid Y µm": 29409.4, + "Num Detections": 18122, + "Num Negative": 17793, + "Num Positive": 329, + "Positive %": 1.815, + "Num Positive per mm^2": 154.53 + } +} \ No newline at end of file diff --git a/144/InvasionFront_CD8_block21_x2_y12_patient144_1.json b/144/InvasionFront_CD8_block21_x2_y12_patient144_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4fc6718b441ecc87f2700d80bda0babb578a5a97 --- /dev/null +++ b/144/InvasionFront_CD8_block21_x2_y12_patient144_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 29459.4, + "Num Detections": 15511, + "Num Negative": 15366, + "Num Positive": 145, + "Positive %": 0.9348, + "Num Positive per mm^2": 75.89 + } +} \ No newline at end of file diff --git a/144/TumorCenter_CD8_block21_x1_y12_patient144_0.json b/144/TumorCenter_CD8_block21_x1_y12_patient144_0.json new file mode 100644 index 0000000000000000000000000000000000000000..554e3ce08651d3bd5f59037d5c105c8fccf8d0e4 --- /dev/null +++ b/144/TumorCenter_CD8_block21_x1_y12_patient144_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5808.4, + "Centroid Y µm": 44094.0, + "Num Detections": 11474, + "Num Negative": 11281, + "Num Positive": 193, + "Positive %": 1.682, + "Num Positive per mm^2": 146.1 + } +} \ No newline at end of file diff --git a/144/TumorCenter_CD8_block21_x2_y12_patient144_1.json b/144/TumorCenter_CD8_block21_x2_y12_patient144_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cca333c3efbdba0fdf456cb9de0cb8ac2191fd35 --- /dev/null +++ b/144/TumorCenter_CD8_block21_x2_y12_patient144_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8201.6, + "Centroid Y µm": 44195.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/144/history_text.txt b/144/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/144/icd_codes.txt b/144/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/144/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/144/ops_codes.txt b/144/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ba59564b597d02f7ec540a4bf3941ca64150d7fc --- /dev/null +++ b/144/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie direkt[1-610.0 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/144/patient_clinical_data.json b/144/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..be062b6415f7a2a54f8586779c00dc2f933f56da --- /dev/null +++ b/144/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/144/patient_pathological_data.json b/144/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..713c9f6aa55c1edc3832b63ce6f1e62fba0becfa --- /dev/null +++ b/144/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "144", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 21.0 +} \ No newline at end of file diff --git a/144/surgery_description.txt b/144/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..794ee1faa89abc40523ba8c805d1cb7c663ab483 --- /dev/null +++ b/144/surgery_description.txt @@ -0,0 +1 @@ +Bilateral neck dissection, Attempted partial laryngectomy / Pharyngectomy according to Lacourreye and completion with laryngectomy diff --git a/144/surgery_report.txt b/144/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c4440fd59595d06e849fd1f30d60a0f120250c9d --- /dev/null +++ b/144/surgery_report.txt @@ -0,0 +1 @@ +First infiltration anesthesia with xylocaine with adrenaline. A modified apron flap is then created. A modified incision is made in the area of the left neck so that a platysmal flap is also dissected. Dissection through the subcutaneous fatty tissue and the platysma on the right side. Dissection of a platysmal flap on the left side. Successive development of the entire apron flap preparation cranially. Fixation with sutures. Now start with the neck dissection on the right side. Exposure of the sternocleidomastoid anterior margin. Expose the digaster muscle and the omohyoid muscle as muscular borders. Dissection along the internal jugular vein and exposure of the cervical vascular sheath with the carotid artery and the vagus nerve. Sparing of these structures. Exposure and sparing of the accessorius nerve. Now preparation and development of the lateral neck preparation while sparing the plexus branches. Deposition after bipolar coagulation caudally. This works well. Now dissect ventrally along the digastric muscle. The capsule of the submandibular gland is included. Expose and protect the hypoglossal nerve in depth. Dissection of the anterior neck preparation without any problems. Now turn to the left side. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and the digaster muscle. Dissection of the internal jugular vein and exposure of the cervical vascular sheath. Sparing of the same. Exposure and sparing of the accessorius nerve. Dissection of the lateral neck preparation while sparing the plexus branches. On the left side there is a lymph node metastasis of approx. 2 cm adherent to the internal jugular vein. However, this metastasis can be bluntly detached from the internal jugular vein. Finally, dissection of the anterior neck preparation, including the capsule of the submandibular gland. Exposure and sparing of the hypgolgossal nerve in depth. Completion of neck dissection on both sides without problems. Attempt partial laryngo/pharyngoectomy according to Lacourreye and laryngectomy as completion. First exposure of the hyoid bone superficially from left to right. Then resection of the hyoid bone and resection of all pre-epiglottic soft tissues, probably on the right side as well as on the left side, leaving the right half of the hyoid bone intact. Dissection up to the pharyngeal tube. Entry into the right paramedian pharyngeal tube. Exposure of the tumor. Cut around the tumor with a safety margin of at least 1 cm in the laryngeal region and up to 1.5 cm in the area of the hypopharyngeal mucosa. Inclusion of the entire epiglottis. Include the thyroid cartilage on the left side up to the level of the cricoid cartilage. Dorsal removal of the largest parts of the aryepiglottic fold, leaving the arytenoid cartilage in the dorsal direction. Parts of the piriform sinus anterior wall must also be resected. The specimen is thread-marked for frozen section. Resection up to this point clearly in healthy tissue and borderline but feasible with regard to meaningful preservation of swallowing function. Very narrow resection margins in the frozen section anteriorly or on the opposite side caudally or posteriorly. A further resection would be associated with a no longer useful functionality of the residual larynx and would increase the risk of aspiration and a permanent tracheostoma. For this reason, further reduction of the residual larynx was avoided and a laryngectomy was now indicated. Extubation of the residual larynx in the typical manner, such as release of the right piriform sinus, detachment of the postcricoid mucosa. Detachment of the piriform constrictor muscle on both sides and the thyroid gland with caudal displacement. The larynx is now removed caudally in the area of the previously placed tracheostomy. The tracheostoma wall remains extended posteriorly in a cranial direction. This is followed by a left myotomy with transection of the fibers of the constrictor pharyngis muscle. This allows much better passage of the finger through the pharyngeal tube. Subsequent insertion of an 8 mm Provox prosthesis in a typical manner without complications. Then closure of the larynx in three layers. First an inverting layer of Vicryl 3.0 single button sutures, followed by a layer of Vicryl 3.0 single button, also inverting. The pharyngeal constrictor muscle is adapted over this to the cranial side. Finally, irrigation of the wound area and layer-by-layer wound closure under a Redon drainage on both sides and epithelialization of the tracheostoma. \ No newline at end of file diff --git a/145/InvasionFront_CD3_block18_x3_y7_patient145_0.json b/145/InvasionFront_CD3_block18_x3_y7_patient145_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9e5e77e283859ffc946e5df126f86ed195de23cb --- /dev/null +++ b/145/InvasionFront_CD3_block18_x3_y7_patient145_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 22213.2, + "Num Detections": 10207, + "Num Negative": 10138, + "Num Positive": 69, + "Positive %": 0.676, + "Num Positive per mm^2": 51.07 + } +} \ No newline at end of file diff --git a/145/InvasionFront_CD3_block18_x4_y7_patient145_1.json b/145/InvasionFront_CD3_block18_x4_y7_patient145_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e5c43b884e2c7c500976a3a074d86539243abd3c --- /dev/null +++ b/145/InvasionFront_CD3_block18_x4_y7_patient145_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 22388.1, + "Num Detections": 17213, + "Num Negative": 16635, + "Num Positive": 578, + "Positive %": 3.358, + "Num Positive per mm^2": 288.3 + } +} \ No newline at end of file diff --git a/145/InvasionFront_CD8_block18_x3_y7_patient145_0.json b/145/InvasionFront_CD8_block18_x3_y7_patient145_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1de21b50b5bd756a55c6ca6753dbe5a32b73c53e --- /dev/null +++ b/145/InvasionFront_CD8_block18_x3_y7_patient145_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11419.0, + "Centroid Y µm": 25036.7, + "Num Detections": 25522, + "Num Negative": 25452, + "Num Positive": 70, + "Positive %": 0.2743, + "Num Positive per mm^2": 25.72 + } +} \ No newline at end of file diff --git a/145/InvasionFront_CD8_block18_x4_y7_patient145_1.json b/145/InvasionFront_CD8_block18_x4_y7_patient145_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0875d98d5104cffeb318d08d52e22f2c81ae9b3 --- /dev/null +++ b/145/InvasionFront_CD8_block18_x4_y7_patient145_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 25186.7, + "Num Detections": 16432, + "Num Negative": 16200, + "Num Positive": 232, + "Positive %": 1.412, + "Num Positive per mm^2": 116.66 + } +} \ No newline at end of file diff --git a/145/TumorCenter_CD3_block18_x3_y7_patient145_0.json b/145/TumorCenter_CD3_block18_x3_y7_patient145_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4cdd2f4d2d85ed2a2bda40ec7e1b0090ac141d6f --- /dev/null +++ b/145/TumorCenter_CD3_block18_x3_y7_patient145_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10690.1, + "Centroid Y µm": 17003.5, + "Num Detections": 21616, + "Num Negative": 21444, + "Num Positive": 172, + "Positive %": 0.7957, + "Num Positive per mm^2": 68.92 + } +} \ No newline at end of file diff --git a/145/TumorCenter_CD3_block18_x4_y7_patient145_1.json b/145/TumorCenter_CD3_block18_x4_y7_patient145_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b479b6a80f58f8bd40f93c08915924fa716b00bc --- /dev/null +++ b/145/TumorCenter_CD3_block18_x4_y7_patient145_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13215.9, + "Centroid Y µm": 17034.7, + "Num Detections": 24083, + "Num Negative": 23926, + "Num Positive": 157, + "Positive %": 0.6519, + "Num Positive per mm^2": 58.58 + } +} \ No newline at end of file diff --git a/145/TumorCenter_CD8_block18_x3_y7_patient145_0.json b/145/TumorCenter_CD8_block18_x3_y7_patient145_0.json new file mode 100644 index 0000000000000000000000000000000000000000..640950a085e3c8f157d4e7c2fb3dc388f3a526f7 --- /dev/null +++ b/145/TumorCenter_CD8_block18_x3_y7_patient145_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10669.4, + "Centroid Y µm": 17790.6, + "Num Detections": 22693, + "Num Negative": 22559, + "Num Positive": 134, + "Positive %": 0.5905, + "Num Positive per mm^2": 52.31 + } +} \ No newline at end of file diff --git a/145/TumorCenter_CD8_block18_x4_y7_patient145_1.json b/145/TumorCenter_CD8_block18_x4_y7_patient145_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5c4b8dea3df673d2e2a46207f716c9c3a4de5b06 --- /dev/null +++ b/145/TumorCenter_CD8_block18_x4_y7_patient145_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13168.0, + "Centroid Y µm": 17815.6, + "Num Detections": 25420, + "Num Negative": 25188, + "Num Positive": 232, + "Positive %": 0.9127, + "Num Positive per mm^2": 85.35 + } +} \ No newline at end of file diff --git a/145/history_text.txt b/145/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..52f3eb44fffb5ba93ecdb9a91123d06c1c087014 --- /dev/null +++ b/145/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed sarcomatoid squamous cell carcinoma G3 on the left. The above-mentioned operation was therefore indicated. \ No newline at end of file diff --git a/145/icd_codes.txt b/145/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ab6661d9e1961b8ac5d8c7aeb2ab2c385bb65f0 --- /dev/null +++ b/145/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des inneren Larynx[C32.0 L] \ No newline at end of file diff --git a/145/ops_codes.txt b/145/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0990a60f6f130d185c49e37a224d0a14ce99800b --- /dev/null +++ b/145/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] CO2-Lasertechnik[5-985.1 ] \ No newline at end of file diff --git a/145/patient_clinical_data.json b/145/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..27c8300bc927a92cca47d8db59bdbff30cd1f42e --- /dev/null +++ b/145/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/145/patient_pathological_data.json b/145/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..51d2ebb3508a3f0bfe4634f5d5b669222da57a37 --- /dev/null +++ b/145/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "145", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": 4.5 +} \ No newline at end of file diff --git a/145/surgery_description.txt b/145/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a777490453c99d3d5c1e0701782ff2ac3fefa7d6 --- /dev/null +++ b/145/surgery_description.txt @@ -0,0 +1 @@ +MLE (Microlaryngoscopy and Endoscopy), Laser resection diff --git a/145/surgery_report.txt b/145/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a621f4e7f3007a6e781a8e22c681a29fa9f220bd --- /dev/null +++ b/145/surgery_report.txt @@ -0,0 +1 @@ +First positioning of the patient after insertion of the laser tube and insertion of the Kleinsasser tube size B. Positioning of the tumor. The tumor can be seen in the area of the anterior half of the vocal fold, extending to the left just before the commissure. Due to the G3 status, resection with a slightly larger safety margin. Resection to the front of the commissure, just above the anterior commissure to the right. Removal of tissue up to the cartilage anteriorly and laterally. Removal of the lower part of the pouch ligament. Resection with a safety margin of approx. 5 mm. Then mark the specimen and send for frozen section. Additional marginal sample from the anterior commissure area. No tumor infiltrates at the margins and in the marginal specimen in the frozen section. Therefore R0 status. Subsequent careful hemostasis. Completion of the procedure without complications. Intraoperative administration of Sobelin 600 mg i.v. Please continue antibiotics for one week. \ No newline at end of file diff --git a/146/InvasionFront_CD3_block4_x3_y12_patient146_0.json b/146/InvasionFront_CD3_block4_x3_y12_patient146_0.json new file mode 100644 index 0000000000000000000000000000000000000000..09975e0c09882229df04192eb5c5f029839e5771 --- /dev/null +++ b/146/InvasionFront_CD3_block4_x3_y12_patient146_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13143.0, + "Centroid Y µm": 35881.0, + "Num Detections": 18130, + "Num Negative": 16053, + "Num Positive": 2077, + "Positive %": 11.46, + "Num Positive per mm^2": 1008.5 + } +} \ No newline at end of file diff --git a/146/InvasionFront_CD3_block4_x4_y12_patient146_1.json b/146/InvasionFront_CD3_block4_x4_y12_patient146_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f164067f32ac80925b90539a98a08970929baa9c --- /dev/null +++ b/146/InvasionFront_CD3_block4_x4_y12_patient146_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 36130.9, + "Num Detections": 16808, + "Num Negative": 14900, + "Num Positive": 1908, + "Positive %": 11.35, + "Num Positive per mm^2": 872.04 + } +} \ No newline at end of file diff --git a/146/InvasionFront_CD8_block4_x3_y12_patient146_0.json b/146/InvasionFront_CD8_block4_x3_y12_patient146_0.json new file mode 100644 index 0000000000000000000000000000000000000000..417f91f24903e077f55823c344034be9aba3b9fb --- /dev/null +++ b/146/InvasionFront_CD8_block4_x3_y12_patient146_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 35081.4, + "Num Detections": 15229, + "Num Negative": 14854, + "Num Positive": 375, + "Positive %": 2.462, + "Num Positive per mm^2": 198.44 + } +} \ No newline at end of file diff --git a/146/InvasionFront_CD8_block4_x4_y12_patient146_1.json b/146/InvasionFront_CD8_block4_x4_y12_patient146_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b3b25f58cc2ddee130b5738ffbefb839940b1d8d --- /dev/null +++ b/146/InvasionFront_CD8_block4_x4_y12_patient146_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 35306.3, + "Num Detections": 16936, + "Num Negative": 16372, + "Num Positive": 564, + "Positive %": 3.33, + "Num Positive per mm^2": 261.49 + } +} \ No newline at end of file diff --git a/146/TumorCenter_CD3_block4_x3_y12_patient146_0.json b/146/TumorCenter_CD3_block4_x3_y12_patient146_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e17b90143bdef856204fb1af9411446c688c7498 --- /dev/null +++ b/146/TumorCenter_CD3_block4_x3_y12_patient146_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11319.0, + "Centroid Y µm": 30783.7, + "Num Detections": 23700, + "Num Negative": 17563, + "Num Positive": 6137, + "Positive %": 25.89, + "Num Positive per mm^2": 2346.1 + } +} \ No newline at end of file diff --git a/146/TumorCenter_CD3_block4_x4_y12_patient146_1.json b/146/TumorCenter_CD3_block4_x4_y12_patient146_1.json new file mode 100644 index 0000000000000000000000000000000000000000..996a9b2a39cf5e455e163b6deb22676b58118b38 --- /dev/null +++ b/146/TumorCenter_CD3_block4_x4_y12_patient146_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 30883.6, + "Num Detections": 20531, + "Num Negative": 19041, + "Num Positive": 1490, + "Positive %": 7.257, + "Num Positive per mm^2": 699.15 + } +} \ No newline at end of file diff --git a/146/TumorCenter_CD8_block4_x3_y12_patient146_0.json b/146/TumorCenter_CD8_block4_x3_y12_patient146_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f2cd3c92618e3acb0c66d2acfa062c2facbb795 --- /dev/null +++ b/146/TumorCenter_CD8_block4_x3_y12_patient146_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 30658.8, + "Num Detections": 24918, + "Num Negative": 21727, + "Num Positive": 3191, + "Positive %": 12.81, + "Num Positive per mm^2": 1213.2 + } +} \ No newline at end of file diff --git a/146/TumorCenter_CD8_block4_x4_y12_patient146_1.json b/146/TumorCenter_CD8_block4_x4_y12_patient146_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f5e967799e7f4622eebfd3b225a8ac96457b2a84 --- /dev/null +++ b/146/TumorCenter_CD8_block4_x4_y12_patient146_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13317.9, + "Centroid Y µm": 30958.6, + "Num Detections": 15413, + "Num Negative": 15317, + "Num Positive": 96, + "Positive %": 0.6229, + "Num Positive per mm^2": 56.31 + } +} \ No newline at end of file diff --git a/146/history_text.txt b/146/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..892fded03ffd7f1ad79f2aae9338be1132c41101 --- /dev/null +++ b/146/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma in the soft palate/hard palate junction. No infiltration of the bone could be identified on CT, albeit with limited assessability. Therefore transoral resection planned and neck dissection. \ No newline at end of file diff --git a/146/icd_codes.txt b/146/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5e81f5a9212b11b948b3b68649c23e15a1cecafb --- /dev/null +++ b/146/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx Seitenwand[C10.2 L] \ No newline at end of file diff --git a/146/ops_codes.txt b/146/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..927a53aec6c1aa213cdf4bb615debc1359a3f03e --- /dev/null +++ b/146/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/146/patient_clinical_data.json b/146/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2e33551a0ccc00c18de4f4c932ace69ff80d349e --- /dev/null +++ b/146/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 47, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/146/patient_pathological_data.json b/146/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bb7b4c3e1ea203ced02b7f957c80314f3a866a21 --- /dev/null +++ b/146/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "146", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/146/surgery_description.txt b/146/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bd7b2a1780b4d015613244410e6b93b627f09df0 --- /dev/null +++ b/146/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor tonsillectomy, PEG placement diff --git a/146/surgery_report.txt b/146/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..84b8c8d94fdcaae36feefdaa6baf05e84b8ee4d3 --- /dev/null +++ b/146/surgery_report.txt @@ -0,0 +1 @@ +Insertion of the oral spatula according to McIvor. Exposure of the tumor. The position of the tumor is shown, which grows from the soft palate in the cranial area and upper tonsil area towards the alveolar ridge and hard palate. First, the tumor is cut around the mucosal area with a safety margin of at least 1 cm in all areas. Resection includes the entire tonsil, anterior palatal arch, mucosa of the alveolar ridge and lower anterior parts of the buccal mucosa. The posterior molar is located at the tumor margins. It is therefore removed. The tumor extends to the alveolar ridge. Push off the bone here. Further removal of the tumor also basally. This is successful in the area of the tonsil or pharyngeal wall. In the area of the pterygoid muscles and the ascending mandibular branch, the tumor grows in depth. This reaches the ascending mandibular branch and clearly erodes it. Further displacement of the tumor from the bone. The inferior alveolar nerve is also infiltrated in the tumor and is removed. Tumor preparation is removed. Suture marking: Suture blue short-short anterior, alveolar ridge lateral short-long, anterior alveolar ridge medial long-long, marginal specimen ( tonsil medial ). Green suture: short-short medial ( hard palate ) short-long cranial at hard palate/cheek junction, long-long soft palate basal retrotonsillar. Suture purple: long-long basal at the level of the soft tissue on the hard palate, short-long soft tissue basal lower tonsil pole. In addition, marginal sample of soft tissue at the lateral alveolar ridge, marginal sample from the buccal fat plug and marginal sample from the buccal mucosa extending from the hard palate to the lateral aleolar ridge. Overall: Bone infiltration with significant bone erosion both in the area of the ascending mandibular branch and in the area of the alveolus in the last molar. Due to the situation, from the maxillofacial surgery department was consulted. Findings confirmed by colleague. Joint decision to transfer patient to maxillofacial surgery, as removal of the mandible and surrounding soft tissue is required for rehabilitation. Primary RCT does not appear to make sense in the case of significant bone infiltration. Subsequent PEG placement. Insertion of the flexible esophagoscope into the stomach. No abnormalities were found on gross examination. After diaphanoscopy, insertion of a 15 mm stomach wall tube without complications. This is fixed to the abdominal wall in the typical manner. Completion of the procedure without complications. The patient should be referred to the maxillofacial surgery department after consultation with colleagues to plan further surgical treatment. \ No newline at end of file diff --git a/147/InvasionFront_CD3_block14_x5_y8_patient147_0.json b/147/InvasionFront_CD3_block14_x5_y8_patient147_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f915fa3d17b4432b8aea74639693c3409604a708 --- /dev/null +++ b/147/InvasionFront_CD3_block14_x5_y8_patient147_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16691.2, + "Centroid Y µm": 24162.2, + "Num Detections": 8302, + "Num Negative": 8147, + "Num Positive": 155, + "Positive %": 1.867, + "Num Positive per mm^2": 121.99 + } +} \ No newline at end of file diff --git a/147/InvasionFront_CD3_block14_x6_y8_patient147_1.json b/147/InvasionFront_CD3_block14_x6_y8_patient147_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dd4a553a06f0c682ba7b306f0370a2296c4c1f73 --- /dev/null +++ b/147/InvasionFront_CD3_block14_x6_y8_patient147_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19364.7, + "Centroid Y µm": 24187.2, + "Num Detections": 20088, + "Num Negative": 19162, + "Num Positive": 926, + "Positive %": 4.61, + "Num Positive per mm^2": 369.25 + } +} \ No newline at end of file diff --git a/147/InvasionFront_CD8_block14_x5_y8_patient147_0.json b/147/InvasionFront_CD8_block14_x5_y8_patient147_0.json new file mode 100644 index 0000000000000000000000000000000000000000..94790f088fe29d569de9e23f7138477c5eaede7c --- /dev/null +++ b/147/InvasionFront_CD8_block14_x5_y8_patient147_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16691.2, + "Centroid Y µm": 19689.6, + "Num Detections": 13104, + "Num Negative": 13002, + "Num Positive": 102, + "Positive %": 0.7784, + "Num Positive per mm^2": 59.3 + } +} \ No newline at end of file diff --git a/147/InvasionFront_CD8_block14_x6_y8_patient147_1.json b/147/InvasionFront_CD8_block14_x6_y8_patient147_1.json new file mode 100644 index 0000000000000000000000000000000000000000..62416afd0fde5a3c7b68d99db8a65300b7b19551 --- /dev/null +++ b/147/InvasionFront_CD8_block14_x6_y8_patient147_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19614.6, + "Centroid Y µm": 19764.5, + "Num Detections": 12703, + "Num Negative": 12591, + "Num Positive": 112, + "Positive %": 0.8817, + "Num Positive per mm^2": 70.57 + } +} \ No newline at end of file diff --git a/147/TumorCenter_CD3_block14_x5_y8_patient147_0.json b/147/TumorCenter_CD3_block14_x5_y8_patient147_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0436f8f76049e603822e0e80c665f6b03c4d8ec9 --- /dev/null +++ b/147/TumorCenter_CD3_block14_x5_y8_patient147_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 20589.1, + "Num Detections": 16476, + "Num Negative": 15896, + "Num Positive": 580, + "Positive %": 3.52, + "Num Positive per mm^2": 258.77 + } +} \ No newline at end of file diff --git a/147/TumorCenter_CD3_block14_x6_y8_patient147_1.json b/147/TumorCenter_CD3_block14_x6_y8_patient147_1.json new file mode 100644 index 0000000000000000000000000000000000000000..789c66452490fcdd596a55125f42be00080fa693 --- /dev/null +++ b/147/TumorCenter_CD3_block14_x6_y8_patient147_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 20764.0, + "Num Detections": 16818, + "Num Negative": 16296, + "Num Positive": 522, + "Positive %": 3.104, + "Num Positive per mm^2": 232.67 + } +} \ No newline at end of file diff --git a/147/TumorCenter_CD8_block14_x5_y8_patient147_0.json b/147/TumorCenter_CD8_block14_x5_y8_patient147_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a68f9d9699b05aedbcecad5296d159e99ee143a6 --- /dev/null +++ b/147/TumorCenter_CD8_block14_x5_y8_patient147_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15716.7, + "Centroid Y µm": 20564.1, + "Num Detections": 15834, + "Num Negative": 15713, + "Num Positive": 121, + "Positive %": 0.7642, + "Num Positive per mm^2": 58.13 + } +} \ No newline at end of file diff --git a/147/TumorCenter_CD8_block14_x6_y8_patient147_1.json b/147/TumorCenter_CD8_block14_x6_y8_patient147_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1647292c4e388e738f7060f4c89a846615fb1472 --- /dev/null +++ b/147/TumorCenter_CD8_block14_x6_y8_patient147_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18215.4, + "Centroid Y µm": 20614.1, + "Num Detections": 16091, + "Num Negative": 16017, + "Num Positive": 74, + "Positive %": 0.4599, + "Num Positive per mm^2": 33.48 + } +} \ No newline at end of file diff --git a/147/history_text.txt b/147/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/147/icd_codes.txt b/147/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d02879c768c1a7734e9cd5ac833bd9035cce98c1 --- /dev/null +++ b/147/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 L] Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] \ No newline at end of file diff --git a/147/ops_codes.txt b/147/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8eab7bc07f9f674da8bbb6770eb56bda601c5f5b --- /dev/null +++ b/147/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.01 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] \ No newline at end of file diff --git a/147/patient_clinical_data.json b/147/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fd612726a6fab455247b316ce919cbc980c0325d --- /dev/null +++ b/147/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 4, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/147/patient_pathological_data.json b/147/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..13ecaaa0721d70a59385e9f12ad05260bcd60bfa --- /dev/null +++ b/147/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "147", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/147/surgery_description.txt b/147/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c1bf2a81cb5ad26f6b15b9e8576e1dd7e774c1a4 --- /dev/null +++ b/147/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Left neck dissection diff --git a/147/surgery_report.txt b/147/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8191bfb7097bf127b1e5e754af2eea8187aa2a8a --- /dev/null +++ b/147/surgery_report.txt @@ -0,0 +1 @@ +First insertion of the mouth guard. This already reveals a massively loose tooth and a bridge on the right lower jaw. Consultation with the anesthetist, who confirms that the prosthesis was already massively loose before the procedure. Suturing of the tongue and now presentation and exposure of the tumor. The tumor is then cut around with the electric nasel with a safety margin of between 0.5 and 0.8 mm. A clear crater appears in the center of the tumor towards the depth. Particularly deep resection in this area. A marginal sample is then taken from this area for a frozen section after the tumor has otherwise been safely removed macroscopically in healthy tissue. The frozen section is found to be tumor-free intraoperatively. Several larger vessels are exposed during dissection and ligated after transection. The resection now extends over the entire edge of the tongue on the left side. The tip of the tongue remains untouched. The base of the tongue also remains untouched. Repeated subtle hemostasis. Then removal of all instruments and repositioning of the patient for hypopharyngeal carcinoma resection. First insertion of the small irrigation tube. The tumor cannot be sufficiently exposed with this. This is followed by laborious insertion of the torso retractor. This allows the tumor to be exposed very well. The tumor extends over the entire lateral wall of the hypopharynx and moves over the lateral wall here into the lateral wall of the piriform sinus. It also slightly touches the anterior wall of the piriform sinus. In the upper part and the plica pharyngoepiglottica. Now cut around the tumor with the CO2 laser with a sufficient safety margin of about 0.5 cm. The tumor is resected down to the pharyngeal musculature and then remains strictly in this plane up to the entrance of the piriform sinus. Partial resection of the plica phayngoepiglottica. The arytenoid cartilage remains completely intact. The tumor is then also incised in the caudal area and then removed. Subtle hemostasis. Representative marginal samples are then taken from the entire area of deposition and the wound bed. One of these marginal samples, called the anterior piriform sinus, is then found to have a carcinoma in situ in the frozen section, so that a further resection and another marginal sample is taken. This marginal sample is then found to be tumor-free intraoperatively, which means that the tumor R0 appears to be resected. Further subtle hemostasis. The resection now reaches into the middle of the piriform sinus. If the wound is dry, remove all instruments. Insertion of a naso-gastric feeding tube. Then reposition for neck dissection on the left side. First injection of local anesthetic with adrenaline at the anterior edge of the sternocleidomastoid muscle. Then skin incision and layer-by-layer dissection in depth. Exposure and transection of the platysma. Exposure of the cervical vascular sheath. From there, long dissection of the cervical vascular sheath from caudal to cranial. Dissection of the landmarks with the omohyoid muscle in the caudal region and the digaster muscle, venter posterior in the cranial region. Also expose the capsule of the submandibular gland. Then expose the accessorius nerve. Clearing of the accessory triangle and preparation of the caudal neck preparation with long-distance preparation of the vagus nerve and the plexus branches of the cervical plexus. Subsequent dissection of the ventral neck preparation, also sparing all branches of the internal jugular vein and external carotid artery, and removal of the hypoglossal triangle, sparing the cervical sinus and hypoglossal nerve. Here, too, all branches of the external carotid artery are spared. Finally, subtle hemostasis. The result is a neck dissection level Ib to V. In the course of the dissection, several enlarged lymph nodes were found, some of which appeared suspicious. If the wound was dry, a Redon drain was inserted followed by two-layer wound closure and dressing. Repeated endaural bleeding control. If the wound is dry, the procedure is ended after a final consultation with the anesthesia colleagues, which was also held at the start of the operation. Further procedure depending on the final histopathological findings as decided by the interdisciplinary tumor conference. \ No newline at end of file diff --git a/148/InvasionFront_CD3_block7_x1_y4_patient148_0.json b/148/InvasionFront_CD3_block7_x1_y4_patient148_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f7a67ee23eb2b439a363b4d41f8cd58f3d1fdd8 --- /dev/null +++ b/148/InvasionFront_CD3_block7_x1_y4_patient148_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4222.8, + "Centroid Y µm": 9619.9, + "Num Detections": 26282, + "Num Negative": 19807, + "Num Positive": 6475, + "Positive %": 24.64, + "Num Positive per mm^2": 2344.3 + } +} \ No newline at end of file diff --git a/148/InvasionFront_CD3_block7_x2_y4_patient148_1.json b/148/InvasionFront_CD3_block7_x2_y4_patient148_1.json new file mode 100644 index 0000000000000000000000000000000000000000..19a634754e41175c7199af4eb7e5ab0c6268895b --- /dev/null +++ b/148/InvasionFront_CD3_block7_x2_y4_patient148_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6721.4, + "Centroid Y µm": 9619.9, + "Num Detections": 24021, + "Num Negative": 22214, + "Num Positive": 1807, + "Positive %": 7.523, + "Num Positive per mm^2": 657.35 + } +} \ No newline at end of file diff --git a/148/InvasionFront_CD8_block7_x1_y4_patient148_0.json b/148/InvasionFront_CD8_block7_x1_y4_patient148_0.json new file mode 100644 index 0000000000000000000000000000000000000000..347046ec35f72aad8d523cfb5bd3ff307fbcb608 --- /dev/null +++ b/148/InvasionFront_CD8_block7_x1_y4_patient148_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 9544.9, + "Num Detections": 27272, + "Num Negative": 25303, + "Num Positive": 1969, + "Positive %": 7.22, + "Num Positive per mm^2": 742.76 + } +} \ No newline at end of file diff --git a/148/InvasionFront_CD8_block7_x2_y4_patient148_1.json b/148/InvasionFront_CD8_block7_x2_y4_patient148_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0bbeabb8f5cca2a53061ec2f8e8a85a7da904a15 --- /dev/null +++ b/148/InvasionFront_CD8_block7_x2_y4_patient148_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8445.5, + "Centroid Y µm": 9844.8, + "Num Detections": 23861, + "Num Negative": 23290, + "Num Positive": 571, + "Positive %": 2.393, + "Num Positive per mm^2": 214.27 + } +} \ No newline at end of file diff --git a/148/TumorCenter_CD3_block7_x1_y4_patient148_0.json b/148/TumorCenter_CD3_block7_x1_y4_patient148_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d3e21dd0369a380dd11686a77a2341660dbfbddf --- /dev/null +++ b/148/TumorCenter_CD3_block7_x1_y4_patient148_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3798.0, + "Centroid Y µm": 9944.7, + "Num Detections": 18374, + "Num Negative": 17350, + "Num Positive": 1024, + "Positive %": 5.573, + "Num Positive per mm^2": 395.68 + } +} \ No newline at end of file diff --git a/148/TumorCenter_CD3_block7_x2_y4_patient148_1.json b/148/TumorCenter_CD3_block7_x2_y4_patient148_1.json new file mode 100644 index 0000000000000000000000000000000000000000..26bdf2b871636e626fdf811b33f9e9d6c52853fc --- /dev/null +++ b/148/TumorCenter_CD3_block7_x2_y4_patient148_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 9994.7, + "Num Detections": 20951, + "Num Negative": 18922, + "Num Positive": 2029, + "Positive %": 9.685, + "Num Positive per mm^2": 769.15 + } +} \ No newline at end of file diff --git a/148/TumorCenter_CD8_block7_x1_y4_patient148_0.json b/148/TumorCenter_CD8_block7_x1_y4_patient148_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2d0de14211c7bb49660cb334c0c69a017cd03744 --- /dev/null +++ b/148/TumorCenter_CD8_block7_x1_y4_patient148_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 10019.7, + "Num Detections": 20904, + "Num Negative": 20707, + "Num Positive": 197, + "Positive %": 0.9424, + "Num Positive per mm^2": 76.89 + } +} \ No newline at end of file diff --git a/148/TumorCenter_CD8_block7_x2_y4_patient148_1.json b/148/TumorCenter_CD8_block7_x2_y4_patient148_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9b9a83396d11c04411bbd32bc8b48ba45c9df562 --- /dev/null +++ b/148/TumorCenter_CD8_block7_x2_y4_patient148_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 10119.6, + "Num Detections": 23202, + "Num Negative": 22976, + "Num Positive": 226, + "Positive %": 0.9741, + "Num Positive per mm^2": 85.9 + } +} \ No newline at end of file diff --git a/148/history_text.txt b/148/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/148/icd_codes.txt b/148/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2d7fc84bff07d6547fc3da21162d2d8a30244a4e --- /dev/null +++ b/148/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, nicht näher bezeichnet[C09.9 ] \ No newline at end of file diff --git a/148/ops_codes.txt b/148/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2b67d5ff66c8db2bbad6b13e04dafed8aae91b79 --- /dev/null +++ b/148/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Anwendung Operation-Roboter - Zusatzcode[5-987 ] Perkutane [endoskopische] Gastrostomie [PEG][5-431.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Selektive Neck dissection in 3 Regionen[5-403.02 R] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 L] \ No newline at end of file diff --git a/148/patient_clinical_data.json b/148/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..71ee5d81e0cb638fc747d89ec42997d50661bc85 --- /dev/null +++ b/148/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/148/patient_pathological_data.json b/148/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2ad49ae797ab534254d3f7661e1ad79b9fcc6864 --- /dev/null +++ b/148/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "148", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/148/surgery_description.txt b/148/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..50312bf02ac9be42bdb574ea1e368d8a571c1efe --- /dev/null +++ b/148/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Neck dissection diff --git a/148/surgery_report.txt b/148/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..611ae3050f9c70fc41d8d6984540e83ddf590247 --- /dev/null +++ b/148/surgery_report.txt @@ -0,0 +1 @@ +PEG insertion: Performing flexible oesophagogastroscopy: Careful endoscopy under visualization into the stomach. The esophageal mucosa is without irritation. The gastric mucosa is also unremarkable, no evidence of ulcer or tumor growth. After a positive diaphanoscopy, a PEG tube is inserted in the typical manner using the thread pull-through method, without complications. Withdrawal of the gastroscope. Dictation : After positioning the patient, inspection of the primary tumor region. A circumscribed exophytic tumor is seen in the area of the left tonsil. This is mainly localized in the caudal part of the tonsil, just exceeds the tonsil border caudally, but otherwise remains limited to the tonsil lobe. After exposure of the tonsillar lobe, insertion of the retractors and positioning of the robotic arms. A robot-assisted tumor resection in the form of a tumor tonsillectomy is now performed. Deep removal of the surrounding musculature. Subtotal removal of the anterior palatal arch. Resection up to the base of the tongue. Macroscopic in sano resection. The specimen is thread-marked for frozen section diagnostics. This shows an R0 situation with a somewhat unclear situation in the area of the caudal margin. Therefore, after discussing the case with the pathologist, a resection is performed, which is sent for definitive histology. Subsequently dry wound conditions and continuation with neck dissection. Dictation : Rearrangement for ND left. , in alternation: landmark marking, infiltration with Ultracaine 2% with added Suprarenin. Signs of the swollen skin incision. Separation of skin and platysma. Exposure of the anterior border of the sternocleidomastoid muscle, then the omohyoid muscle, then the submandibular muscle and digaster muscle. Finding the internal jugular vein. Visualization of the accessorius nerve. An approx. 2 cm large suspicious lymph node is found in level IV above the VJI. Also an approx. 2 cm large suspicious lymph node in level II. Resection of the two presumed metastases for further dissection on the vein. Now the posterior neck preparation is released from cranial to caudal along the cervical vascular sheath from levels II, III and IV. Bleeding from an artery in level IIb, presumably the lingual artery. Ligation of the same. Blustilla. Further ligation of another vessel. Hemostasis. Protection of the accessorius nerve during level IIb evacuation. Exposure and sparing of the hypoglossal nerve and the facial artery/vein, the carotid artery and the vagus nerve. The bifurcation contains enlarged LK, which do not appear clinically suspicious. Protection of the plexus branches. Removal of the anterior neck preparation. Finally, hemostasis with the bipolar. Insertion of a Redon drainage, two-layer wound closure. Dictation : Transfer to ND right: On the right side there is a previous operation in the sense of a carotid operation, therefore the incision is essentially made in the old scar. Only in the very cranial area is the incision moved slightly dorsally, as the scar area extends very far into the parotid gland. Exposure of the sternocleidomastoid muscle. This is somewhat more difficult due to scarring from the previous operation. Exposure of the omohyoid muscle and the submandibular gland. Finding the cervical vascular sheath. This is slightly altered by the previous operation and has moved further medially. Free preparation of the internal jugular vein. Locating the accessorius nerve and clearing Level IIb, aIII and IV while sparing the plexus branches. Insertion of a 10 Redon drain. Two-layer wound closure. \ No newline at end of file diff --git a/149/InvasionFront_CD3_block12_x5_y12_patient149_0.json b/149/InvasionFront_CD3_block12_x5_y12_patient149_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c8601b9cafa5628ae84e57084aa048f771a62df7 --- /dev/null +++ b/149/InvasionFront_CD3_block12_x5_y12_patient149_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15341.9, + "Centroid Y µm": 34731.6, + "Num Detections": 12909, + "Num Negative": 11774, + "Num Positive": 1135, + "Positive %": 8.792, + "Num Positive per mm^2": 766.9 + } +} \ No newline at end of file diff --git a/149/InvasionFront_CD3_block12_x6_y12_patient149_1.json b/149/InvasionFront_CD3_block12_x6_y12_patient149_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b4b21e087f59ef42c90a3c68b662f433741c062a --- /dev/null +++ b/149/InvasionFront_CD3_block12_x6_y12_patient149_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17565.7, + "Centroid Y µm": 34881.5, + "Num Detections": 16912, + "Num Negative": 15710, + "Num Positive": 1202, + "Positive %": 7.107, + "Num Positive per mm^2": 656.3 + } +} \ No newline at end of file diff --git a/149/InvasionFront_CD8_block12_x5_y12_patient149_0.json b/149/InvasionFront_CD8_block12_x5_y12_patient149_0.json new file mode 100644 index 0000000000000000000000000000000000000000..991d0883c8f9897d0e7f885502acc1d79164db98 --- /dev/null +++ b/149/InvasionFront_CD8_block12_x5_y12_patient149_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17765.6, + "Centroid Y µm": 33332.4, + "Num Detections": 12183, + "Num Negative": 11611, + "Num Positive": 572, + "Positive %": 4.695, + "Num Positive per mm^2": 400.8 + } +} \ No newline at end of file diff --git a/149/InvasionFront_CD8_block12_x6_y12_patient149_1.json b/149/InvasionFront_CD8_block12_x6_y12_patient149_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d64638e0239a9d0f060bc63b92875923c1ca595c --- /dev/null +++ b/149/InvasionFront_CD8_block12_x6_y12_patient149_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20164.3, + "Centroid Y µm": 33356.0, + "Num Detections": 16130, + "Num Negative": 15561, + "Num Positive": 569, + "Positive %": 3.528, + "Num Positive per mm^2": 308.92 + } +} \ No newline at end of file diff --git a/149/TumorCenter_CD3_block12_x5_y12_patient149_0.json b/149/TumorCenter_CD3_block12_x5_y12_patient149_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4c6c03a2890f7a3f03c8274d29b15de1104f4ade --- /dev/null +++ b/149/TumorCenter_CD3_block12_x5_y12_patient149_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15216.9, + "Centroid Y µm": 29684.3, + "Num Detections": 15539, + "Num Negative": 14575, + "Num Positive": 964, + "Positive %": 6.204, + "Num Positive per mm^2": 538.88 + } +} \ No newline at end of file diff --git a/149/TumorCenter_CD3_block12_x6_y12_patient149_1.json b/149/TumorCenter_CD3_block12_x6_y12_patient149_1.json new file mode 100644 index 0000000000000000000000000000000000000000..939f02fb84eb7e58aae6b348c7c5f152b885247d --- /dev/null +++ b/149/TumorCenter_CD3_block12_x6_y12_patient149_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17540.7, + "Centroid Y µm": 29734.3, + "Num Detections": 13046, + "Num Negative": 11973, + "Num Positive": 1073, + "Positive %": 8.225, + "Num Positive per mm^2": 693.96 + } +} \ No newline at end of file diff --git a/149/TumorCenter_CD8_block12_x5_y12_patient149_0.json b/149/TumorCenter_CD8_block12_x5_y12_patient149_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c7939d3a9b19b4cc9f12d5adce9cdb8f8fca68bd --- /dev/null +++ b/149/TumorCenter_CD8_block12_x5_y12_patient149_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17965.5, + "Centroid Y µm": 39204.2, + "Num Detections": 13469, + "Num Negative": 13158, + "Num Positive": 311, + "Positive %": 2.309, + "Num Positive per mm^2": 179.41 + } +} \ No newline at end of file diff --git a/149/TumorCenter_CD8_block12_x6_y12_patient149_1.json b/149/TumorCenter_CD8_block12_x6_y12_patient149_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5398d94d945ef956cd811e57c464d17acd2ad14d --- /dev/null +++ b/149/TumorCenter_CD8_block12_x6_y12_patient149_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20514.1, + "Centroid Y µm": 39304.2, + "Num Detections": 10277, + "Num Negative": 10079, + "Num Positive": 198, + "Positive %": 1.927, + "Num Positive per mm^2": 133.05 + } +} \ No newline at end of file diff --git a/149/history_text.txt b/149/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/149/icd_codes.txt b/149/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7a1d9c681a930b46d3826c7f09c84d5d3b102c7f --- /dev/null +++ b/149/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des postkrikoidalen Hypopharynx[C13.0 ] Neubildung bösartig Hypopharynx sonstige[C13.8 ] \ No newline at end of file diff --git a/149/ops_codes.txt b/149/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c69fc32c093f0eb5131dfbb5b6725fe8bec9fe5 --- /dev/null +++ b/149/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit gestieltem regionalen Lappen[5-303.12 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Spalthautdeckung großflächig Empfängerstelle Brustwand und Rücken[5-902.4a ] Entnahme von Spalthaut am Oberschenkel[5-901.0e R] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Diagnostische indirekte Orohypopharyngoskopie[1-611.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische ÖGD[1-632 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] \ No newline at end of file diff --git a/149/patient_clinical_data.json b/149/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..15b7edecdbf3d6d1478b877fece8160a587c0818 --- /dev/null +++ b/149/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 9, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": null, + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/149/patient_pathological_data.json b/149/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..81bba78ca896cf37a42c054052f4e2509af0a715 --- /dev/null +++ b/149/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "149", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 66, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/149/surgery_description.txt b/149/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..360b83c74b008ec2d1459d4c1c966ddd3cb2bb5c --- /dev/null +++ b/149/surgery_description.txt @@ -0,0 +1 @@ +TU resection, Neck dissection diff --git a/149/surgery_report.txt b/149/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..87c329fada61c754c6a27951efa2ecd8d737ea9b --- /dev/null +++ b/149/surgery_report.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the right. This is followed by a repeat panendoscopy preoperatively in domo after an external endoscopy. Tracheoscopy: Inconspicuous mucosal conditions subglottic to carina. Oro-hypopharyngoscopy: Inconspicuous mucosal conditions in the oropharynx, base of tongue and tonsil region. Inspection and palpation unremarkable. Hypopharynx left inconspicuous. From the end of the oropharynx to the beginning of the hypopharyngeal entrance on the left, an exophytic tumor is visible, which fills the entire piriform sinus from the lateral wall over the medial wall and over the postcricoid area to the opposite side. Esophageal entrance free. The above-mentioned operation is therefore confirmed, although the indication for flap plasty can probably only be definitively determined intraoperatively. PEG placement: Advancement of the flexible esophagoscope into the stomach. No evidence of tumor on gross examination, but conspicuous hyperplastic ......stone-like mucosal conditions in the cardia and corpus, antrum flatter. Check-up by an internist recommended. A 15 mm abdominal wall probe is then inserted in the typical manner after diaphanoscopy. Fixation to the abdominal wall. Subsequent repositioning for neck dissection on both sides, laryngectomy. Injection not possible. Sterile draping after skin disinfection. An apron flap is first created subplatysmally in the typical manner up to the level of the hyoid bone and submandibular gland, whereby the capsule should be included in the neck preparation. Subsequent neck dissection, initially on the right side: visualization of the sternocleidomastoid anterior border, visualization of the omohyoid muscle, digastric muscle. Exposure of the cervical vascular sheath. V. jugularis interna, facialis, A. carotis interna and externa as well as A. carotis communis. Exposure and preservation of vagus nerve, hypoglossal nerve, accessorius nerve. Subsequent removal of the medial neck preparation, initially preserving the superior thyroid artery. Then develop the dorsal neck specimen, exposing and preserving the branches of the cervical plexus. Careful hemostasis and irrigation with H202 and Ringer's solution. Overall evacuation level 2-5, whereby suspicious nodes were found in the cranial area level 2. Neck dissection on the left side: This is performed in the same way as on the right side. Level 2-5 clearance is also performed here, followed by laryngectomy and subtotal pharyngectomy. First, exposure and skeletonization of the hyoid bone and removal of the suprahyoid muscles. Removal of the prelaryngeal soft tissue, which is preserved as level 6. Subsequent dissection of the infrahyoid musculature from the hyoid bone and cutting caudally. On the left, problem-free skeletonization of the larynx by ...... of the superior chorda and dissection of the constrictor pharyngis muscle as well as dissection of the thyroid gland caudo-laterally. Dissection of the piriform sinus on this side. The superior thyroid artery is exposed and preserved. Subsequent dissection on the opposite side in the direction of the tumor. It becomes apparent that the tumor has most likely infiltrated the soft tissue next to the pharyngeal wall. Therefore, the upper pole of the thyroid gland is undercut and resected. In the area of the thyroid resection region, a suture is placed under and over the wall. The larynx is resected as a whole up to the thyroid gland, including the pharyngeal wall and upper thyroid pole. All soft tissue in the hyoid bone area is also resected pre-epiglottis. Now enter the left paramedian larynx. A tumor is revealed. This is resected successively with a safety margin of at least 1 to 1 ˝ cm in all directions. The entire pharyngeal wall on the right including the posterior wall is removed. A remnant of the posterior wall and the entire lateral piriform sinus wall remain. The entire postcricoid region must be resected in the direction of the esophageal opening, resulting in unfavorable and very narrow conditions. Before this, the thyroid isthmus, which is very thin, is cut through and the trachea is exposed and the trachea is opened in the 1st/2nd intercartilaginous space and sutured to the skin of the neck. The larynx with the entire pharyngeal wall on the right including the upper pole of the thyroid gland and the entire postcricoid region up to the esophageal entrance is then removed. The specimen is thread-marked and sent for frozen section examination. Carcinoma in situ on the left side in the frozen section. A 2-3 mm thick strip from the left resection margin is therefore cut again. Subsequently, another marginal sample approx. 2 mm wide is taken, which is also marked with a suture. The frozen section still shows mild to moderate dysplasia, no indication for further resection. Thus an overall R0 situation. What remains is a strip that is too narrow, barely 2-3 cm wide, particularly in the direction of the esophageal opening. Primary suturing does not seem sensible in terms of preserving the swallowing function. The decision was therefore made to cover the defect with a flap. Due to the patient's poor vascular situation, his secondary diseases and the favorable soft tissue conditions in the thoracic region, which allow a very thin flap to be elevated, the defect is covered using a pectoralis major flap from the right. First, the entire wound area was irrigated with H202 and Ringer's solution and the bleeding was carefully stopped. Then measure the size of the defect. Flap size is 10 x 8 cm. Corresponding trapezoidal shape in the direction of the esophageal opening. This is followed by elevation of the pectoralis major flap, provox creation and defect coverage in the pharyngeal region: after measuring the length of the pedicle, the defect is marked on the thoracic wall. Subfascial elevation of a bridge of the deltopectoral flap is then performed. Dissection under the pectoralis muscle and exposure of the vascular pedicle. Subsequently, successive incision of the skin island and development of the myocutaneous pectoralis major flap along the flap pedicle, taking into account the course of the vessel. Dissection up to the clavicle. Subsequent careful hemostasis in the thoracic region. Pull the pedicle through under the further deltopectoral skin bridge. Insertion of the skin island into the defect area. First myotomy and placement of the Provox prosthesis. For this purpose, the muscles on the left side in the area of the constrictor pharyngis muscle are successively cut with the scalpel and the scissors up to the mucosa. This allows better passage of the finger into the esophageal opening. Subsequent insertion of an 8.0 Provox prosthesis in a typical manner without complications. Insertion takes place 1-1.5 cm below the upper tracheal border. Then successive suturing of the pectoralis major flap into the defect, taking particular care to ensure that the passage into the upper esophagus is not too narrow. Tension-free suturing of the flap. Left lateral and cranial 2nd muscle suture over the flap. Muscle pedicle comes to lie over the suture on the right side. Careful hemostasis again. Irrigation with Ringer's solution. Skin closure in the neck area by placing the apron flap back with insertion of a Redon drainage in each side of the neck and epithelialization of the tracheostoma. Insertion of a 9 mm tracheal cannula. Now wound closure in the thorax area. It turns out that the skin can no longer be mobilized in such a way that primary closure is possible. Therefore covering in the thigh area. Split skin 0.5 mm thick is removed with the dermatome. Primary closure in the thoracic region as far as possible. A residual defect remains, which is covered with split skin. A total of 2 Redon drains are inserted in the axillary area and next to the flap pedicle. Mepilex with Chitogel is applied to the thoracic wound and thigh wound as a wound dressing. The procedure was completed without complications. Overall cT3-4 hypopharyngeal carcinoma with infiltration of the postcricoid area and larynx. At least cN2b status. Patient goes to intensive care unit for postoperative monitoring. Please continue antibiotics for a total of one week with Unacid 1.5 g 3 x/die. Feeding via inserted PEG for 10 days, then gruel and, if necessary, diet build-up. Inserted feeding tube should remain in place for splinting. \ No newline at end of file diff --git a/150/InvasionFront_CD3_block7_x3_y11_patient150_0.json b/150/InvasionFront_CD3_block7_x3_y11_patient150_0.json new file mode 100644 index 0000000000000000000000000000000000000000..01cde91b0a1f8e92e93e128b4445e9ce0cdd8c41 --- /dev/null +++ b/150/InvasionFront_CD3_block7_x3_y11_patient150_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11375.3, + "Centroid Y µm": 26726.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/150/InvasionFront_CD3_block7_x4_y11_patient150_1.json b/150/InvasionFront_CD3_block7_x4_y11_patient150_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6037df82dbea92a2e7e86f9a0a05db286ca7b432 --- /dev/null +++ b/150/InvasionFront_CD3_block7_x4_y11_patient150_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 26735.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/150/InvasionFront_CD8_block7_x3_y11_patient150_0.json b/150/InvasionFront_CD8_block7_x3_y11_patient150_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d3cf5b7646ca23048adb2b6399f51484995026a --- /dev/null +++ b/150/InvasionFront_CD8_block7_x3_y11_patient150_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 27660.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/150/InvasionFront_CD8_block7_x4_y11_patient150_1.json b/150/InvasionFront_CD8_block7_x4_y11_patient150_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e264eb8368f1cb28c422815da39ae631ffb7c39d --- /dev/null +++ b/150/InvasionFront_CD8_block7_x4_y11_patient150_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 27960.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/150/TumorCenter_CD3_block7_x3_y11_patient150_0.json b/150/TumorCenter_CD3_block7_x3_y11_patient150_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6d6ec5f32be77a13ba4bca0189831af2ce64164 --- /dev/null +++ b/150/TumorCenter_CD3_block7_x3_y11_patient150_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 27785.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/150/TumorCenter_CD3_block7_x4_y11_patient150_1.json b/150/TumorCenter_CD3_block7_x4_y11_patient150_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f0fbdddb9c8a66dce99e2def302fdd19af250bb --- /dev/null +++ b/150/TumorCenter_CD3_block7_x4_y11_patient150_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 27835.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/150/TumorCenter_CD8_block7_x3_y11_patient150_0.json b/150/TumorCenter_CD8_block7_x3_y11_patient150_0.json new file mode 100644 index 0000000000000000000000000000000000000000..075c027b4c079559e33123c1d5e4bc849db6b769 --- /dev/null +++ b/150/TumorCenter_CD8_block7_x3_y11_patient150_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10594.4, + "Centroid Y µm": 27385.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/150/TumorCenter_CD8_block7_x4_y11_patient150_1.json b/150/TumorCenter_CD8_block7_x4_y11_patient150_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e9ba959303ea416f66a200e30b99084ee488780c --- /dev/null +++ b/150/TumorCenter_CD8_block7_x4_y11_patient150_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13268.0, + "Centroid Y µm": 27410.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/150/history_text.txt b/150/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/150/icd_codes.txt b/150/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f2f0150692ff7080fa7fd838e15669ef7c2c600a --- /dev/null +++ b/150/icd_codes.txt @@ -0,0 +1 @@ +Karzinom bei unbekanntem Primärtumor (CUP)[C80.0 ] \ No newline at end of file diff --git a/150/ops_codes.txt b/150/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..96e59df6a79ea844bf5a80b63c59300c31e3e290 --- /dev/null +++ b/150/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Tonsillektomie [ohne Adenotomie] mit Dissektionstechnik[5-281.0 ] Probeexzision am Nasopharynx[1-548 ] Biopsie an der Zunge ohne Inzision[1-420.1 ] Indirekte Epipharyngoskopie[1-611.1 ] \ No newline at end of file diff --git a/150/patient_clinical_data.json b/150/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e41ba2d7de730ad45a2f0465cf97cc3770d5c726 --- /dev/null +++ b/150/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin + cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/150/patient_pathological_data.json b/150/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cf87cd69537b36de60015d489d27555f78b159fc --- /dev/null +++ b/150/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "150", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/150/surgery_description.txt b/150/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2deb19d0e5dd55055c03b999f95e455967767ee3 --- /dev/null +++ b/150/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, CUP panendoscopy, PE (Proximal esophagus) diff --git a/150/surgery_report.txt b/150/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b4b324e74383611eb326c9ccb9926835db29762 --- /dev/null +++ b/150/surgery_report.txt @@ -0,0 +1 @@ +First, an introductory consultation with the anesthesia colleagues. This included laryngoscopic placement of the glottic plane and inspection of the trachea, subglottis and main bronchi, which revealed normal mucosal conditions. The surgeon then intubates the patient without any problems. Flexible esophagogastroscopy. The flexible instrument is inserted into the oesophagus without any problems and the patient is visualized as far as the stomach, where a regular folded relief can be seen. Aspiration of the insufflated air. Then mirror back and carefully inspect the esophageal mucosa, which is also non-irritating and inconspicuous. Now reposition the patient and inspect the oral cavity, oropharynx, pharynx and larynx with the size C Kleinsasser tube. Here, too, the mucous membrane is free of irritation and inconspicuous with no evidence of a tumor. Insertion of the TE blocker. Inspection of the tonsil regions on both sides. Palpation of the left tonsil, which is slightly indurated. Start with tonsillectomy of the left side. Mucosal incision close to the uvula and subsequent sharp dissection of the anterior and posterior palatal arch. Then detachment of the tonsil from the upper pole after exposing and severing and coagulation of the pole vessels. Further dissection of the tonsil with the raspatory. Repeated coagulation of smaller vessel inflows. Finally, dissection up to the lower tonsil pole and removal of the tonsil. Subsequent coagulation of the lower pole vessels with a portion of the tongue base tonsil. Then perform a palatal arch plasty and move to the right side. Identical procedure here. The palatal arch plasty was also performed at the end of the operation. The right side was also removed with a portion of the tongue base tonsil. Careful inspection of the tonsils. These are largely unremarkable and are sent separately for histopathological examination. Then insertion of the velo tractio and indirect inspection of the epipharynx. Adenoid tissue is also seen here, no evidence of a tumor. Then curettage of the nasopharynx and this preparation is also sent separately for histopathological examination. Then careful hemostasis is performed. Adjustment of the base of the tongue with the small water tube. This is also visible and palpable. Take biopsies from both sides and the middle. These are also sent for histopathological examination. Then careful hemostasis here too. All instruments are removed and the patient is repositioned for neck dissection on the left side. Injection of local anesthetic with adrenaline. Now start with an incision along the sternocleidomastoid. Dissection in layers in depth. Cut through the platysma. Ligation of the external jugular vein. Further exposure and dissection in depth. Here, search for the cervical vascular sheath. This is then dissected over a long distance. Exposure of the vagus nerve, which is displaced medially and re-embedded here in the sense of a neurolysis. Severe scarring in the area of the venous angle and a lymph node conglomerate can be seen. Extremely careful dissection here. The conglomerate is also firmly attached to the hypoglossal triangle. Here the hypoglossal nerve is located via the cervical profunda. Long-distance dissection of the nerve of both the cervical profunda and the hypoglossal nerve. The hypoglossal nerve is dissected free from its bed and displaced cranially. Lateral to the cervical vascular sheath, the accessorius nerve is then accessed. Long-distance nerve preparation here too. Perform neurolysis and re-embedding of the nerve. Finally, removal of the entire hypoglossal triangle and the lateral neck preparation. Dissection of the neck preparation ventral to the cervical vascular sheath. All venous and arterial vessels are preserved here. At the end of the dissection, a neck dissection of level Ib, II, III, IV results. At the end, careful hemostasis and irrigation of the wound. Insertion of a Redon drainage and two-layer wound closure. Then application of a pressure bandage and completion of the procedure. Final consultation with anesthesia colleagues. Further procedure depending on the findings of the histological tissue examinations. \ No newline at end of file diff --git a/151/InvasionFront_CD3_block8_x5_y11_patient151_0.json b/151/InvasionFront_CD3_block8_x5_y11_patient151_0.json new file mode 100644 index 0000000000000000000000000000000000000000..51c4409322b58c577749c83df91fc8d5772e753d --- /dev/null +++ b/151/InvasionFront_CD3_block8_x5_y11_patient151_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16593.7, + "Centroid Y µm": 37681.4, + "Num Detections": 23238, + "Num Negative": 21893, + "Num Positive": 1345, + "Positive %": 5.788, + "Num Positive per mm^2": 519.37 + } +} \ No newline at end of file diff --git a/151/InvasionFront_CD3_block8_x6_y11_patient151_1.json b/151/InvasionFront_CD3_block8_x6_y11_patient151_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3ad510011908ec476af5e8ef6c5e55e814c1f970 --- /dev/null +++ b/151/InvasionFront_CD3_block8_x6_y11_patient151_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19141.1, + "Centroid Y µm": 37747.6, + "Num Detections": 24489, + "Num Negative": 21628, + "Num Positive": 2861, + "Positive %": 11.68, + "Num Positive per mm^2": 1087.3 + } +} \ No newline at end of file diff --git a/151/InvasionFront_CD8_block8_x5_y11_patient151_0.json b/151/InvasionFront_CD8_block8_x5_y11_patient151_0.json new file mode 100644 index 0000000000000000000000000000000000000000..32bf5766f15051d59f1cec0e2a7e5bef0b5684f3 --- /dev/null +++ b/151/InvasionFront_CD8_block8_x5_y11_patient151_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 28285.0, + "Num Detections": 21300, + "Num Negative": 12998, + "Num Positive": 8302, + "Positive %": 38.98, + "Num Positive per mm^2": 3165.1 + } +} \ No newline at end of file diff --git a/151/InvasionFront_CD8_block8_x6_y11_patient151_1.json b/151/InvasionFront_CD8_block8_x6_y11_patient151_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e4554c282a91007cdc89aa035c4d27fdefaf5cac --- /dev/null +++ b/151/InvasionFront_CD8_block8_x6_y11_patient151_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 28584.9, + "Num Detections": 23197, + "Num Negative": 12699, + "Num Positive": 10498, + "Positive %": 45.26, + "Num Positive per mm^2": 3874.3 + } +} \ No newline at end of file diff --git a/151/TumorCenter_CD3_block8_x5_y11_patient151_0.json b/151/TumorCenter_CD3_block8_x5_y11_patient151_0.json new file mode 100644 index 0000000000000000000000000000000000000000..91a00accc9d8d167231b818ec44727965f0d9192 --- /dev/null +++ b/151/TumorCenter_CD3_block8_x5_y11_patient151_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 28584.9, + "Num Detections": 25003, + "Num Negative": 19262, + "Num Positive": 5741, + "Positive %": 22.96, + "Num Positive per mm^2": 2027.7 + } +} \ No newline at end of file diff --git a/151/TumorCenter_CD3_block8_x6_y11_patient151_1.json b/151/TumorCenter_CD3_block8_x6_y11_patient151_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d7cf2c68983b4dd2bbba5165d01a60537d467e82 --- /dev/null +++ b/151/TumorCenter_CD3_block8_x6_y11_patient151_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20938.9, + "Centroid Y µm": 28060.1, + "Num Detections": 25459, + "Num Negative": 18397, + "Num Positive": 7062, + "Positive %": 27.74, + "Num Positive per mm^2": 2451.2 + } +} \ No newline at end of file diff --git a/151/TumorCenter_CD8_block8_x5_y11_patient151_0.json b/151/TumorCenter_CD8_block8_x5_y11_patient151_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5a38f1ed3f5c6c8ed3e3d8d98b7998aa01c17d8c --- /dev/null +++ b/151/TumorCenter_CD8_block8_x5_y11_patient151_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17490.7, + "Centroid Y µm": 27610.4, + "Num Detections": 27668, + "Num Negative": 20551, + "Num Positive": 7117, + "Positive %": 25.72, + "Num Positive per mm^2": 2482.9 + } +} \ No newline at end of file diff --git a/151/TumorCenter_CD8_block8_x6_y11_patient151_1.json b/151/TumorCenter_CD8_block8_x6_y11_patient151_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c07d68254e578ed8770c70485308dd85e4f5633e --- /dev/null +++ b/151/TumorCenter_CD8_block8_x6_y11_patient151_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 27435.5, + "Num Detections": 27659, + "Num Negative": 20243, + "Num Positive": 7416, + "Positive %": 26.81, + "Num Positive per mm^2": 2545.7 + } +} \ No newline at end of file diff --git a/151/history_text.txt b/151/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c999a2b2433c8a4c94c93962168e844a3707043 --- /dev/null +++ b/151/history_text.txt @@ -0,0 +1 @@ +The patient had undergone external lymph node extirpation <2013> and a biopsy from the left tonsil area. The histological work-up revealed a diagnosis of G2-3 squamous cell carcinoma in each case. Hence the indication for the above-mentioned procedure. \ No newline at end of file diff --git a/151/icd_codes.txt b/151/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..914febab322d93a8d2df607d8ed5a25e9641dd17 --- /dev/null +++ b/151/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Seitenwand des Oropharynx[C10.2 ] \ No newline at end of file diff --git a/151/ops_codes.txt b/151/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..173f71fa0a4d56545d7d12903d9f4a08797a07bf --- /dev/null +++ b/151/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Transorale Tumortonsillektomie[5-281.2 ] \ No newline at end of file diff --git a/151/patient_clinical_data.json b/151/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5db788afdbab17e239b644f037174884fe110bf7 --- /dev/null +++ b/151/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/151/patient_pathological_data.json b/151/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..df3b1506cf96136f750c9938b27595a33410a9af --- /dev/null +++ b/151/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "151", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 12, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/151/surgery_description.txt b/151/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..419c3a5f916564321e2350c16a9456731b04ba83 --- /dev/null +++ b/151/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy, Panendoscopy diff --git a/151/surgery_report.txt b/151/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a253111dd638d6584ccb0729dbd83ac2b500e51c --- /dev/null +++ b/151/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, the surgeon first performs a tracheoscopy. The trachea is freely visible up to the bifurcation. Subsequent intubation by the surgeon without any problems. Entry with the esophagoscope under constant air insufflation into the stomach. Inversion. Inspection of the gastric mucosa. Inconspicuous conditions here. On retraction of the esophagoscope, inspection of the esophageal mucosa. Here, in the area of the cardioesophageal junction, there are clearly irritated conditions in the sense of a chronic reflux problem. This should be clarified internally in the course of the procedure. Now enter with the Kleinsasser tube and inspect the piriform sinuses on both sides, the vallecula, the base of the tongue, the epiglottis and the endolarynx. Inconspicuous conditions here. Inspection of the postcricoid region. Here also unremarkable conditions. Now adjusting with the Mc Ivor spatula. Inspection of the oral cavity. The rough mass can already be felt in the area of the left tonsil. Now dissect the tumor far into the healthy tissue. Start in the area of the anterior palatal arch. Dissection with the electric needle. Finally, the tumor is developed from cranial to caudal. The glossotonsillar groove falls. The mucosa in the area of the alveolar ridge is removed, the bone is not exposed. Ultimately, the tumor is detached from the pharyngeal musculature. An arterial pharyngeal branch and a presumed outlet of the lingual artery are lanced. Finally, the tumor is removed far into the healthy tissue. The removed tumor is thread-marked with short short caudal, short long medial, long long cranial and green thread short short basal. The specimen is sent for final histology. Bipolar hemostasis. The posterior palatal arch could be preserved as far as possible. Relaxing the Mc Ivor spatula, 5 minutes. Re-inspection. No more evidence of further bleeding. The procedure was completed without complications. Conclusion: Overall left tumor tonsillectomy. No evidence of a second malignancy on panendoscopy. An appointment for the left neck dissection has been arranged for <2014>. \ No newline at end of file diff --git a/152/InvasionFront_CD3_block18_x5_y9_patient152_0.json b/152/InvasionFront_CD3_block18_x5_y9_patient152_0.json new file mode 100644 index 0000000000000000000000000000000000000000..532b28ce06aa6b640a1c96764118d663a581e18e --- /dev/null +++ b/152/InvasionFront_CD3_block18_x5_y9_patient152_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 27485.4, + "Num Detections": 17170, + "Num Negative": 17132, + "Num Positive": 38, + "Positive %": 0.2213, + "Num Positive per mm^2": 20.07 + } +} \ No newline at end of file diff --git a/152/InvasionFront_CD3_block18_x6_y9_patient152_1.json b/152/InvasionFront_CD3_block18_x6_y9_patient152_1.json new file mode 100644 index 0000000000000000000000000000000000000000..25af3b03bb308fe24ef31d09e6d99e249a7d0b3c --- /dev/null +++ b/152/InvasionFront_CD3_block18_x6_y9_patient152_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 27610.4, + "Num Detections": 15765, + "Num Negative": 15709, + "Num Positive": 56, + "Positive %": 0.3552, + "Num Positive per mm^2": 31.91 + } +} \ No newline at end of file diff --git a/152/InvasionFront_CD8_block18_x5_y9_patient152_0.json b/152/InvasionFront_CD8_block18_x5_y9_patient152_0.json new file mode 100644 index 0000000000000000000000000000000000000000..67715ecb1650cbac2441a14593f39a17d74d371d --- /dev/null +++ b/152/InvasionFront_CD8_block18_x5_y9_patient152_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 29984.1, + "Num Detections": 16402, + "Num Negative": 15687, + "Num Positive": 715, + "Positive %": 4.359, + "Num Positive per mm^2": 380.48 + } +} \ No newline at end of file diff --git a/152/InvasionFront_CD8_block18_x6_y9_patient152_1.json b/152/InvasionFront_CD8_block18_x6_y9_patient152_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3bddd354a1c46ba1ff77164098cc0caf81b28fab --- /dev/null +++ b/152/InvasionFront_CD8_block18_x6_y9_patient152_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 29959.1, + "Num Detections": 14841, + "Num Negative": 14778, + "Num Positive": 63, + "Positive %": 0.4245, + "Num Positive per mm^2": 36.51 + } +} \ No newline at end of file diff --git a/152/TumorCenter_CD3_block18_x5_y9_patient152_0.json b/152/TumorCenter_CD3_block18_x5_y9_patient152_0.json new file mode 100644 index 0000000000000000000000000000000000000000..030b98f44bd2392596e17a84bb7d7acca715912e --- /dev/null +++ b/152/TumorCenter_CD3_block18_x5_y9_patient152_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15566.8, + "Centroid Y µm": 21938.4, + "Num Detections": 14204, + "Num Negative": 14175, + "Num Positive": 29, + "Positive %": 0.2042, + "Num Positive per mm^2": 15.8 + } +} \ No newline at end of file diff --git a/152/TumorCenter_CD3_block18_x6_y9_patient152_1.json b/152/TumorCenter_CD3_block18_x6_y9_patient152_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a72f4bf14daa756e72b54aab2a89bef14e6aa294 --- /dev/null +++ b/152/TumorCenter_CD3_block18_x6_y9_patient152_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 21963.4, + "Num Detections": 18295, + "Num Negative": 18213, + "Num Positive": 82, + "Positive %": 0.4482, + "Num Positive per mm^2": 43.31 + } +} \ No newline at end of file diff --git a/152/TumorCenter_CD8_block18_x5_y9_patient152_0.json b/152/TumorCenter_CD8_block18_x5_y9_patient152_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3bc6b708bead5776638749e7b649aba9323516c3 --- /dev/null +++ b/152/TumorCenter_CD8_block18_x5_y9_patient152_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15691.7, + "Centroid Y µm": 22762.9, + "Num Detections": 14292, + "Num Negative": 14031, + "Num Positive": 261, + "Positive %": 1.826, + "Num Positive per mm^2": 141.17 + } +} \ No newline at end of file diff --git a/152/TumorCenter_CD8_block18_x6_y9_patient152_1.json b/152/TumorCenter_CD8_block18_x6_y9_patient152_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf81d4286c622f8ed58913ddc68d000d82fd88bf --- /dev/null +++ b/152/TumorCenter_CD8_block18_x6_y9_patient152_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18115.4, + "Centroid Y µm": 22837.9, + "Num Detections": 15722, + "Num Negative": 15431, + "Num Positive": 291, + "Positive %": 1.851, + "Num Positive per mm^2": 156.32 + } +} \ No newline at end of file diff --git a/152/history_text.txt b/152/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/152/icd_codes.txt b/152/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..32387c1fcf6c54331e14f8f7b72a80346efbb392 --- /dev/null +++ b/152/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] Bösartige Neubildung: Larynx, mehrere Teilbereiche überlappend[C32.8 ] Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] Lymphknotenvergrößerung, umschrieben[R59.0 ] \ No newline at end of file diff --git a/152/ops_codes.txt b/152/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f9f25b68a6c9b63ca7fb9731a02a32190278f9e0 --- /dev/null +++ b/152/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie: Mit Pharyngektomie: Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 6 Regionen[5-403.05 L] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Permanente Tracheostomie: Re-Tracheotomie[5-312.1 ] \ No newline at end of file diff --git a/152/patient_clinical_data.json b/152/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..21ed884354707583b358e1f2c83d84bb7de454b1 --- /dev/null +++ b/152/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2008, + "age_at_initial_diagnosis": 49, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/152/patient_pathological_data.json b/152/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..21e6e7233dac77747030c694c98ae0c3cb22930f --- /dev/null +++ b/152/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "152", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4b", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 25.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/152/surgery_description.txt b/152/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..faa168e7163291ab5bb72bc7b31d389252890660 --- /dev/null +++ b/152/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy with partial pharyngectomy, Bilateral neck dissection, Re-tracheotomy, Endoscopy diff --git a/152/surgery_report.txt b/152/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..506535194e451065998e97eb286d4d3fcbfb3ef2 --- /dev/null +++ b/152/surgery_report.txt @@ -0,0 +1 @@ +At the start of the operation, the surgeon positions the patient. After induction of anesthesia, 3 g of Unacid is administered i.v. The oropharynx, hypopharynx and larynx are then inspected again. The tumor is as described above and in comparison with the CT scan, the tumor is limited to the left hypopharynx. The tip of the piriform sinus, the entrance to the esophagus and the entire piriform sinus on the right are tumor-free. The larynx appears infiltrated like a tumor, the thyroid cartilage is perforated. On the left, the tumor attaches to the hyoid bone. After repositioning and alcohol disinfection with infiltration anesthesia, the skin incision is made on the right side along the anterior edge of the sternocleidomastoid. Clearing out the lateral neck preparation after exposing the cervical vascular sheath and the accessorius nerve as well as the deep cervical plexus branches. From cranial to caudal to below the omohyoid muscle and then dissection medially along the digastric muscle onto the capsule of the submandibular gland. Clear the medial neck preparation, also exposing the hypoglossal nerve and protecting it. Locating the superior laryngeal nerve with its accompanying vessels. Ligation of the same. Now identical procedure on the left side. Here, tumor lymph nodes are seen extending to the mastoid and in the supraclavicular fossa far to the lateral and nuchal side, also skin incision along the anterior edge of the sternocleidomastoid. Exposure of the accessor nerve, which is surrounded by tumor masses but can be bluntly released from them. Dissection of the cervical vascular sheath in its course. Exposure of the vagus nerve and the deep cervical plexus branches. Locate the thoracic duct and dissect it laterally. It becomes apparent that the tumor-infiltrated lymph nodes extend far to the side and infiltrate the accessorius at the posterior edge of the sternocleidomastoid. It was therefore decided to remove the accessorius and sternocleidomastoid cranially and to explore the neck block laterally in one piece. Also remove and cut the cervical plexus branches. Dissect down to the first rib caudally and laterally to near the acromioclavicular joint. Dissect nuchally to below the trapezius muscle, clearing out the complete regions 1, 2, 3, 4, 5 and 6. Dissect cranially to the prelaryngeal muscles and to the capsule of the submandibular gland; the hypoglossal nerve can also be exposed and preserved here. Subsequently raise the apron flap and turn towards the larynx. Dissect the infrahyoid muscles from the hyoid bone and knock them down. This shows that, as already suspected, the left paramedian thyroid cartilage has been perforated and the tumor is infiltrating the prelaryngeal musculature. The detached musculature is readapted using Vicryl sutures. The right prelaryngeal musculature is then separated and knocked down. The right piriform sinus is then detached from the thyroid cartilage skeleton. Subsequent right paramedian approach to the epiglottis and opening of the pharynx. Preservation of the linugal epiglottis mucosa and preparation of the aryepiglottic fold to the ary on the right side. Separation of the piriform sinus from the cricoid cartilage, resection of the tumor now under visual control, including parts of the base of the tongue and the lateral pharyngeal wall on the left up to parts of the piriform sinus. The posterior pharyngeal wall remains completely intact, as does the tip of the left piriform sinus. Now carefully stop the bleeding. Removal of the laryngeal preparation, taking the former tracheostoma with it, previously creating a new tracheostoma with placement of the lower tracheostoma sutures. Now removal of the hyoid bone, which appears to have been attached to the tumor on the left. Therefore, removal of the hyoid bone with part of the surrounding musculature while sparing the hypoglossal nerve for final histology as a resection. Representative marginal samples are then taken, which are found to be tumor-free by pathology, so that a safe R0 resection can be assumed. In the further course, consultation of from the phoniatrics department. Application of a size 8 provox prosthesis in the typical manner. Finally, careful hemostasis. H202 irrigation Insertion of 2 Redon drains. Inverting pharyngeal suture. Subsequent two-layer wound closure in the midline. Finally, renewed irrigation, check for wound dryness and two-layer skin suture and readaptation of the remaining tracheostoma. Intraoperatively, 2 x 3 g of Unacid were administered, antibiotics should be continued for 5 days, the patient was admitted to the intensive care unit awake. \ No newline at end of file diff --git a/153/InvasionFront_CD3_block6_x5_y7_patient153_0.json b/153/InvasionFront_CD3_block6_x5_y7_patient153_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5014f5cfcde49ef0a37f3463f717cdd2af21fc13 --- /dev/null +++ b/153/InvasionFront_CD3_block6_x5_y7_patient153_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17066.0, + "Centroid Y µm": 18540.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/153/InvasionFront_CD3_block6_x6_y7_patient153_1.json b/153/InvasionFront_CD3_block6_x6_y7_patient153_1.json new file mode 100644 index 0000000000000000000000000000000000000000..db73c7a1bb0630dfe4d74ae391300d946d220fa1 --- /dev/null +++ b/153/InvasionFront_CD3_block6_x6_y7_patient153_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19639.6, + "Centroid Y µm": 18715.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/153/InvasionFront_CD8_block6_x5_y5_patient153_0.json b/153/InvasionFront_CD8_block6_x5_y5_patient153_0.json new file mode 100644 index 0000000000000000000000000000000000000000..db70580cd95570f29ae7bb8c554da0d9547f22b5 --- /dev/null +++ b/153/InvasionFront_CD8_block6_x5_y5_patient153_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17590.7, + "Centroid Y µm": 12693.3, + "Num Detections": 14469, + "Num Negative": 14279, + "Num Positive": 190, + "Positive %": 1.313, + "Num Positive per mm^2": 90.1 + } +} \ No newline at end of file diff --git a/153/InvasionFront_CD8_block6_x6_y5_patient153_1.json b/153/InvasionFront_CD8_block6_x6_y5_patient153_1.json new file mode 100644 index 0000000000000000000000000000000000000000..54f8734a2718917935db3139b9d2603cad1a7847 --- /dev/null +++ b/153/InvasionFront_CD8_block6_x6_y5_patient153_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20264.3, + "Centroid Y µm": 12918.2, + "Num Detections": 15428, + "Num Negative": 14399, + "Num Positive": 1029, + "Positive %": 6.67, + "Num Positive per mm^2": 455.46 + } +} \ No newline at end of file diff --git a/153/TumorCenter_CD3_block6_x5_y5_patient153_0.json b/153/TumorCenter_CD3_block6_x5_y5_patient153_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba040e04192904faef62517448af4936540469c3 --- /dev/null +++ b/153/TumorCenter_CD3_block6_x5_y5_patient153_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 12718.3, + "Num Detections": 15886, + "Num Negative": 14618, + "Num Positive": 1268, + "Positive %": 7.982, + "Num Positive per mm^2": 576.62 + } +} \ No newline at end of file diff --git a/153/TumorCenter_CD3_block6_x6_y5_patient153_1.json b/153/TumorCenter_CD3_block6_x6_y5_patient153_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8696f2f9695b4369327d4d7434b9816a9f3dbfc1 --- /dev/null +++ b/153/TumorCenter_CD3_block6_x6_y5_patient153_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 12768.2, + "Num Detections": 16602, + "Num Negative": 13932, + "Num Positive": 2670, + "Positive %": 16.08, + "Num Positive per mm^2": 1353.8 + } +} \ No newline at end of file diff --git a/153/TumorCenter_CD8_block6_x5_y5_patient153_0.json b/153/TumorCenter_CD8_block6_x5_y5_patient153_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5d261ebb535dbc9f05eaaab42ff19a0bef89d657 --- /dev/null +++ b/153/TumorCenter_CD8_block6_x5_y5_patient153_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 13118.1, + "Num Detections": 18272, + "Num Negative": 17513, + "Num Positive": 759, + "Positive %": 4.154, + "Num Positive per mm^2": 331.46 + } +} \ No newline at end of file diff --git a/153/TumorCenter_CD8_block6_x6_y5_patient153_1.json b/153/TumorCenter_CD8_block6_x6_y5_patient153_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0197cc0a722b6431a7eca89aa6f13e14f7eba601 --- /dev/null +++ b/153/TumorCenter_CD8_block6_x6_y5_patient153_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 13068.1, + "Num Detections": 18109, + "Num Negative": 16103, + "Num Positive": 2006, + "Positive %": 11.08, + "Num Positive per mm^2": 936.13 + } +} \ No newline at end of file diff --git a/153/history_text.txt b/153/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/153/icd_codes.txt b/153/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/153/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/153/ops_codes.txt b/153/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..742277f68bb4e46db086a8996dd82ef7168ea543 --- /dev/null +++ b/153/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] Sonstige radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.x4 ] Temporäre Tracheotomie[5-311.0 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] \ No newline at end of file diff --git a/153/patient_clinical_data.json b/153/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..00629310016918d95abbab180ff62b5dcf23843f --- /dev/null +++ b/153/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 53, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/153/patient_pathological_data.json b/153/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d59c3d494a325acdd44fa06c034b858c5c397259 --- /dev/null +++ b/153/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "153", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/153/surgery_description.txt b/153/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..21e149247a29d814c4cbf02d5f8b48249686eb94 --- /dev/null +++ b/153/surgery_description.txt @@ -0,0 +1 @@ +Right tumor tonsillectomy, Bilateral neck dissection, Defect coverage, Pedicled flap (Pectoralis major) diff --git a/153/surgery_report.txt b/153/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..101544d704a5a6dad0f21499a7e58a65cf1643bf --- /dev/null +++ b/153/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, a plastic tracheostoma is first created in the usual way. Sterile wiping and covering of the patient and injection of supra in the area of the U-shaped incision. Start of the operation by tracheotomy. To do this, make an incision below the cricoid. Cut through the cutaneous and subcutaneous tissue. Exposure of the infralaryngeal musculature and division of the musculature in the midline. Identification of the cricoid cartilage and sharp dissection of the cricoid cartilage. Undermining of the thyroid isthmus and coagulation of the same. After transection of the thyroid isthmus, identification of the anterior tracheal wall and sharp entry into the 2nd to 3rd intertracheal annular gap and creation of a tracheostoma in the usual manner using epithelializing single-button sutures. Insertion of an 8-gauge tracheostomy tube. Subsequent transition to transoral tumor resection. Once the tumor has been positioned, the tumor, which occupies the right tonsil lobe, is resected caudally starting parauvularly macroscopically in healthy musculature using the ultrasonic knife. Laterally, the resection margin extends to the soft tissue of the neck. Caudally, the glossotonsillar groove as well as adjacent parts of the base of the tongue must be included in the resected area. The entire resectate is then sent for a frozen section histological examination for orientation. This reveals narrow resection margins in the area of the tumor base as well as in the area of the base of the tongue. Therefore, a transoral resection from the base of the tumor is performed as far as possible, as well as an extensive resection in the area of the medial base of the tongue. These prove to be free of tumor on frozen section histology. Subsequent transition to neck dissection, initially on the right side. After making the apron flap incision, a radical neck dissection is performed here, as the large metastasis has already infiltrated the internal jugular vein together with the sternocleidomastoid muscle and the accessorius nerve. The vascular nerve sheath is therefore located caudally, the jugular vein is exposed and then cut off and severed. The sternocleidomastoid muscle is also cut caudally. The entire preparation is thus successively developed cranially with resection of parts of the cervical plexus. The hypoglossal nerve as well as the common carotid artery and external carotid artery can be dissected from the metastasis in a healthy layer. The cranial resection also includes the caudal part of the parotid gland. Finally, the internal jugular vein is exposed just below the jugular foramen, dissected free and also removed there. Creation of a Redon suction drainage. Transition to neck dissection on the opposite side. There is no evidence of a suspicious lymph node metastasis. Selective neck dissection is performed in regions II to V, sparing all non-lymphatic structures. Then skeletonize the lingual artery, which will later be used for anastomosis. On the right side, create the passage into the hypopharynx from the lateral side. With a good view of the caudal resection margin, tissue from the adjacent tongue base and the vallecula to the lingual epiglottis is resected again and examined using frozen section histology. This was also found to be R0. In addition, the external carotid artery is freed of all remaining fatty and connective tissue in the oropharyngeal direction in the sense of a further resection from the tumor base; this tissue is also ultimately found to be tumor-free on frozen section histology, so that an overall R0 resection can be assumed. Subsequent removal of a radial lobe graft of the appropriate size by . Elevation of the radial forearm flap on the left by : Palpatory identification of the distal radial artery. Marking of the flap borders (6 x 10 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Covering of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Subsequent removal of region I with resection of the submandibular gland on the right side after exposing and sparing the ramus marginalis mandibulae. The radial flap is then inserted into the oropharyngeal defect and sutured into the defect starting transorally. The final sutures are placed transcervically from the caudal side. The vascular pedicle is then guided to the opposite side. Here the lingual artery is anastomosed end-to-end with the radial artery. The venous anastomoses are made through 2 veins of the radial flap in an end-to-side manner to the internal jugular vein. Finally, a Redon suction drain and a flap are placed in the left side of the neck in the usual manner. Folding back of the apron flap, completion of the mucocutaneous anastomosis of the tracheostoma and two-layer wound closure in the usual manner. Suturing of the tracheostomy tube after reintubation of the patient and completion of the procedure and transfer of the patient to anesthesia. Placement of the PEG tube: Flexible pre-scanning with the gastroesophagoscope into the stomach. Identification of the anterior wall of the stomach and performance of a positive diaphanoscopy. Insertion of the PEG tube in the usual manner using the thread pull-through method without complications. Careful reflection and termination of the PEG insertion without complications. Conclusion: Combined transoral-transcervical tumor resection of an oropharyngeal carcinoma with extension into the glossotonsillar groove on the right side. Radical neck dissection on the right and selective neck dissection on the left, reconstruction of the oropharyngeal defect on the right with a microvascularly anastomosed radial flap graft from the left forearm, creation of a plastic tracheostoma and a PEG tube, anastomosis of the microvascular radial flap graft on the opposite side to the lingual artery and in an end-to-side manner to the internal jugular vein. \ No newline at end of file diff --git a/154/InvasionFront_CD3_block20_x3_y7_patient154_0.json b/154/InvasionFront_CD3_block20_x3_y7_patient154_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b99050de0a84434a7c0e80c319cf939456d401a6 --- /dev/null +++ b/154/InvasionFront_CD3_block20_x3_y7_patient154_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12198.3, + "Centroid Y µm": 17308.6, + "Num Detections": 14972, + "Num Negative": 14677, + "Num Positive": 295, + "Positive %": 1.97, + "Num Positive per mm^2": 149.2 + } +} \ No newline at end of file diff --git a/154/InvasionFront_CD3_block20_x4_y7_patient154_1.json b/154/InvasionFront_CD3_block20_x4_y7_patient154_1.json new file mode 100644 index 0000000000000000000000000000000000000000..816757ba3ea18bf2760d4e90e3d4209e21fcf854 --- /dev/null +++ b/154/InvasionFront_CD3_block20_x4_y7_patient154_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14590.0, + "Centroid Y µm": 17486.0, + "Num Detections": 15968, + "Num Negative": 15425, + "Num Positive": 543, + "Positive %": 3.401, + "Num Positive per mm^2": 284.92 + } +} \ No newline at end of file diff --git a/154/InvasionFront_CD8_block20_x3_y7_patient154_0.json b/154/InvasionFront_CD8_block20_x3_y7_patient154_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1ac8b1fae51177a6e4edc047f24183f3df9137b2 --- /dev/null +++ b/154/InvasionFront_CD8_block20_x3_y7_patient154_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12060.3, + "Centroid Y µm": 17642.7, + "Num Detections": 14851, + "Num Negative": 14299, + "Num Positive": 552, + "Positive %": 3.717, + "Num Positive per mm^2": 279.91 + } +} \ No newline at end of file diff --git a/154/InvasionFront_CD8_block20_x4_y7_patient154_1.json b/154/InvasionFront_CD8_block20_x4_y7_patient154_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0183e6310cb4bccc3576578a04e6ca154cbd388c --- /dev/null +++ b/154/InvasionFront_CD8_block20_x4_y7_patient154_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14217.5, + "Centroid Y µm": 17665.6, + "Num Detections": 15301, + "Num Negative": 14515, + "Num Positive": 786, + "Positive %": 5.137, + "Num Positive per mm^2": 407.18 + } +} \ No newline at end of file diff --git a/154/TumorCenter_CD3_block20_x3_y7_patient154_0.json b/154/TumorCenter_CD3_block20_x3_y7_patient154_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5e486d0938cc5c418fe9a67643133161b082ed8e --- /dev/null +++ b/154/TumorCenter_CD3_block20_x3_y7_patient154_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11152.5, + "Centroid Y µm": 16758.2, + "Num Detections": 10509, + "Num Negative": 10489, + "Num Positive": 20, + "Positive %": 0.1903, + "Num Positive per mm^2": 11.35 + } +} \ No newline at end of file diff --git a/154/TumorCenter_CD3_block20_x4_y7_patient154_1.json b/154/TumorCenter_CD3_block20_x4_y7_patient154_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9f9d54dec8234e8aff040fa91bc1687501e5ae1b --- /dev/null +++ b/154/TumorCenter_CD3_block20_x4_y7_patient154_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13779.6, + "Centroid Y µm": 16724.8, + "Num Detections": 10306, + "Num Negative": 10278, + "Num Positive": 28, + "Positive %": 0.2717, + "Num Positive per mm^2": 16.29 + } +} \ No newline at end of file diff --git a/154/TumorCenter_CD8_block20_x3_y7_patient154_0.json b/154/TumorCenter_CD8_block20_x3_y7_patient154_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4145889f4c7b2bac6be23bcaeb942f605488b12e --- /dev/null +++ b/154/TumorCenter_CD8_block20_x3_y7_patient154_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 17565.7, + "Num Detections": 15482, + "Num Negative": 15354, + "Num Positive": 128, + "Positive %": 0.8268, + "Num Positive per mm^2": 66.11 + } +} \ No newline at end of file diff --git a/154/TumorCenter_CD8_block20_x4_y7_patient154_1.json b/154/TumorCenter_CD8_block20_x4_y7_patient154_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd10b3ebdcc5217fad29f3632bcdce6f07f1279d --- /dev/null +++ b/154/TumorCenter_CD8_block20_x4_y7_patient154_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 17415.8, + "Num Detections": 15125, + "Num Negative": 14972, + "Num Positive": 153, + "Positive %": 1.012, + "Num Positive per mm^2": 77.96 + } +} \ No newline at end of file diff --git a/154/history_text.txt b/154/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f0ad1fac39c72e947b8a1d6f9cca8cb602855f3 --- /dev/null +++ b/154/history_text.txt @@ -0,0 +1 @@ +The patient underwent induction chemotherapy for the initial T2 glottic carcinoma on the right, as the patient initially refused a laryngectomy and surgery. However, induction chemotherapy did not lead to tumor reduction but to tumor progression, so that a laryngectomy ultimately had to be performed. \ No newline at end of file diff --git a/154/icd_codes.txt b/154/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0f992959a7915d2f9d2c4717e91053e5aa1670d7 --- /dev/null +++ b/154/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Glottiskarzinom[C32.0 B] \ No newline at end of file diff --git a/154/ops_codes.txt b/154/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d6b8c610b93d1dc0366cb05a5481b7e817965dee --- /dev/null +++ b/154/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] Myotomie sonstige[5-850.xx B] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] PEG-Sonde Anlage[5-431.2 ] \ No newline at end of file diff --git a/154/patient_clinical_data.json b/154/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f7b3e647bddd0a41ee95dd016a86fa47a5300131 --- /dev/null +++ b/154/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 98, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin + docetaxel", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/154/patient_pathological_data.json b/154/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c7453e552d8182074f44693f46c18112a77aeff5 --- /dev/null +++ b/154/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "154", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 18.0 +} \ No newline at end of file diff --git a/154/surgery_description.txt b/154/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fe46b8d204657f7ea44267a33a8c88406bc8eff3 --- /dev/null +++ b/154/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, and PEG placement diff --git a/154/surgery_report.txt b/154/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8fd9e04e9e3c361c24684839de7dde7f2632182d --- /dev/null +++ b/154/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthetist. Then entry with the Kleinsasser tube and inspection of the hypopharynx and larynx. No abnormalities in the hypopharynx including the piriform sinus on both sides. Inspection of the laryngeal plane. Here, an exophytic tumor is seen in the area of the vocal folds with a transition to the pocket folds on both sides. The vocal folds themselves are no longer visible. The arytenoids are glassy swollen on both sides and on the right side the tumor extends to the ary. A definite infiltration on the right side of the arytenoid cartilage cannot be confirmed. A nasogastric tube is then inserted. Insertion with the flexible esophagoscope and pre-scanning into the stomach. If the diaphanoscopy is good, a PEG tube is inserted using the thread pull-through method. The skin incision is then made in the form of an apron flap. As the patient has already undergone a tracheostomy due to shortness of breath, the stoma is also incised so that part of the trachea can also be removed. A subglottic extension of the tumor was described. Then dissection of the apron flap in the usual manner below the platysma. Then fixation and suturing of the wound edges. Then skeletonization of the hyoid bone with detachment of the musculature and the base of the tongue. Then skeletonization of the larynx and detachment of the oblique laryngeal musculature. However, this prelaryngeal musculature is left on the larynx. A CT scan cannot rule out the possibility of a thyroid cartilage rupture 100%. At the very least, the thyroid cartilage is eroded and, for oncological safety reasons, a relatively large amount of tissue must be left on the outside of the larynx. Then skeletonize the thyroid cartilage upper horns on both sides, incise the periosteum and push off the piriform sinus on both sides, then perform the pharyngotomy above the hyoid bone. Pull out the epiglottis and incise the pharyngeal mucosa on both sides along the edges of the epiglottis up to the postcricoid region; a relatively large amount of the pharyngeal mucosa must be removed on the right side as the tumor borders are close to the palpation. A lot of mucosa can be saved on the left side. Dissection of the thyroid gland and visualization of the trachea. Deposition of the larynx in the upper tracheal area so that the former upper edge of the stoma is integrated into the specimen. Then take marginal samples in the pharyngeal mucosa area and send for frozen section. No tumor remnants and no carcinoma in situ in the frozen section. The laryngeal specimen itself is macroscopically far removed from the healthy tissue and is sent for final histology. Neck dissection is then performed by . First on the right side. Exposure of the sternocleidomastoid muscle. Then expose the cervical vascular sheath, dissect the internal jugular vein, locate and expose the accessorius nerve, expose the submandibular gland and the hypopglossus, clear out levels IIa, III, IV and V while sparing the plexus branches. Then neck dissection on the opposite side (left through ): Exposure of the sternocleidomastoid muscle here too. Exposure of the cervical vascular sheath, dissection of the internal jugular vein, exposure of the submandibular gland, hypoglossal nerve and accessorius nerve, then clearing of levels IIa to IV while sparing the plexus branches. Then perform the pharyngeal suture in the usual manner with single button sutures for the 1st and 2nd suture, then partial readaptation of the constrictor pharyngis muscle as far as possible. Perform a myotomy on the sternocleidomastoid muscle to achieve a flat stoma. Incision of the stoma, placement of 2 Redon drains. A provox was of course placed before the pharyngeal suture. This involves palpation of the esophageal entrance, which is very wide, so there is no need for a myotomy in the esophagus; you can almost pass through it with 2 QF. The Provox is performed in the usual way using the pull-through method. A size 8 Provox is inserted. The operation is completed without complications. Please continue antibiotics for 3 days. The patient should be fed via the PEG tube for 10 days and then receive another swallow of gruel. If there is no fistula, gradually build up the diet. After receiving the histology, presentation at the tumor conference. \ No newline at end of file diff --git a/155/InvasionFront_CD3_block14_x5_y4_patient155_0.json b/155/InvasionFront_CD3_block14_x5_y4_patient155_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6f32d51af6bb10019d5c6e0764dd3b2ff9774a89 --- /dev/null +++ b/155/InvasionFront_CD3_block14_x5_y4_patient155_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17240.9, + "Centroid Y µm": 14017.6, + "Num Detections": 16907, + "Num Negative": 15868, + "Num Positive": 1039, + "Positive %": 6.145, + "Num Positive per mm^2": 543.14 + } +} \ No newline at end of file diff --git a/155/InvasionFront_CD3_block14_x6_y4_patient155_1.json b/155/InvasionFront_CD3_block14_x6_y4_patient155_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a2cdf40cea1709be40a1c2a31e227613ca4dd3e --- /dev/null +++ b/155/InvasionFront_CD3_block14_x6_y4_patient155_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19889.5, + "Centroid Y µm": 13967.6, + "Num Detections": 20036, + "Num Negative": 18107, + "Num Positive": 1929, + "Positive %": 9.628, + "Num Positive per mm^2": 878.87 + } +} \ No newline at end of file diff --git a/155/InvasionFront_CD8_block14_x5_y4_patient155_0.json b/155/InvasionFront_CD8_block14_x5_y4_patient155_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1a974a1bf54ba30c05a2506dc43d2190b234cfa2 --- /dev/null +++ b/155/InvasionFront_CD8_block14_x5_y4_patient155_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16991.0, + "Centroid Y µm": 9594.9, + "Num Detections": 18202, + "Num Negative": 17540, + "Num Positive": 662, + "Positive %": 3.637, + "Num Positive per mm^2": 344.04 + } +} \ No newline at end of file diff --git a/155/InvasionFront_CD8_block14_x6_y4_patient155_1.json b/155/InvasionFront_CD8_block14_x6_y4_patient155_1.json new file mode 100644 index 0000000000000000000000000000000000000000..efc2f82b6b37fe917528a9eb17e99cf6b67c2d67 --- /dev/null +++ b/155/InvasionFront_CD8_block14_x6_y4_patient155_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19489.7, + "Centroid Y µm": 9744.8, + "Num Detections": 20949, + "Num Negative": 18832, + "Num Positive": 2117, + "Positive %": 10.11, + "Num Positive per mm^2": 955.47 + } +} \ No newline at end of file diff --git a/155/TumorCenter_CD3_block14_x5_y4_patient155_0.json b/155/TumorCenter_CD3_block14_x5_y4_patient155_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b6ac22ef5390f7e064ebde0befafef09dbf09e2a --- /dev/null +++ b/155/TumorCenter_CD3_block14_x5_y4_patient155_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17041.0, + "Centroid Y µm": 10669.4, + "Num Detections": 17097, + "Num Negative": 13849, + "Num Positive": 3248, + "Positive %": 19.0, + "Num Positive per mm^2": 1489.9 + } +} \ No newline at end of file diff --git a/155/TumorCenter_CD3_block14_x6_y4_patient155_1.json b/155/TumorCenter_CD3_block14_x6_y4_patient155_1.json new file mode 100644 index 0000000000000000000000000000000000000000..22b35b144e338b10a0036b9eeea7cfbb0033da48 --- /dev/null +++ b/155/TumorCenter_CD3_block14_x6_y4_patient155_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19464.7, + "Centroid Y µm": 10844.3, + "Num Detections": 16055, + "Num Negative": 15335, + "Num Positive": 720, + "Positive %": 4.485, + "Num Positive per mm^2": 353.05 + } +} \ No newline at end of file diff --git a/155/TumorCenter_CD8_block14_x5_y4_patient155_0.json b/155/TumorCenter_CD8_block14_x5_y4_patient155_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c4762cca3d1e65939a2ff0483e2054c10fabc9de --- /dev/null +++ b/155/TumorCenter_CD8_block14_x5_y4_patient155_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 10669.4, + "Num Detections": 18588, + "Num Negative": 15829, + "Num Positive": 2759, + "Positive %": 14.84, + "Num Positive per mm^2": 1256.7 + } +} \ No newline at end of file diff --git a/155/TumorCenter_CD8_block14_x6_y4_patient155_1.json b/155/TumorCenter_CD8_block14_x6_y4_patient155_1.json new file mode 100644 index 0000000000000000000000000000000000000000..10eff839c54793066509b7b006883f2ec82d00f8 --- /dev/null +++ b/155/TumorCenter_CD8_block14_x6_y4_patient155_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 10719.3, + "Num Detections": 17641, + "Num Negative": 17131, + "Num Positive": 510, + "Positive %": 2.891, + "Num Positive per mm^2": 249.38 + } +} \ No newline at end of file diff --git a/155/history_text.txt b/155/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..33765ee70b82d736595a9972d6f51a06cb8e32dd --- /dev/null +++ b/155/history_text.txt @@ -0,0 +1 @@ +The patient underwent a tumor resection with neck on both sides and radial flap today. 2 hours postoperatively there is increasing neck swelling with a lump on the right side. The patient's neck is opened and there is continuous bleeding, so the patient is taken to the operating room. \ No newline at end of file diff --git a/155/icd_codes.txt b/155/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a7b8adb568187e40d946b96630ec208a8b840551 --- /dev/null +++ b/155/icd_codes.txt @@ -0,0 +1 @@ +Nachblutung[T81.0 B] \ No newline at end of file diff --git a/155/ops_codes.txt b/155/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5d6a9329e921c614200e14aa3a54b0491b374da6 --- /dev/null +++ b/155/ops_codes.txt @@ -0,0 +1 @@ +Operative Blutstillung nach Gefäß-OP Gefäße Kopf und Hals extrakraniell[5-394.0 ] \ No newline at end of file diff --git a/155/patient_clinical_data.json b/155/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5fd6515e43fdb283099cbf18825a526ba6c9487a --- /dev/null +++ b/155/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 47, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/155/patient_pathological_data.json b/155/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..482a575260d4c1a713735274f96c88658cdadc05 --- /dev/null +++ b/155/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "155", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 74, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/155/surgery_description.txt b/155/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..984ba268150fe34793ffac8d082f40c4091b7889 --- /dev/null +++ b/155/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheotomy, PEG placement, Defect coverage diff --git a/155/surgery_report.txt b/155/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..89a13f7bbe25ced003afb9f4b9f8a8feda622aa2 --- /dev/null +++ b/155/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation through the tracheostoma by the anesthesia colleague. Then opening of the right side of the neck. Irrigation. Diffuse bleeding can be seen in the area of the dissected skin flap under the platysma, then in all muscular areas. Inspection of the anastomosis under the microscope. Dry conditions in both the arterial and venous areas. The blood supply to the flap is good. Careful hemostasis in the area of the musculature and insertion of a new Redon drainage. A breakthrough to the left side was made intraoperatively in the 1st operation, from which blood is also continuously drained, therefore the left side must also be opened again and here too the same picture of diffuse bleeding. Hemostasis using bipolar coagulation and hydrogen. Then insertion of a Redon drainage and two-layer wound closure on both sides. The coagulation diagnostics are unremarkable, but it is striking that the previously over 300,000 thrombocysts have decreased to 17,000,000, possibly due to heparin. The patient received 0.4 m Clexane preoperatively and the graft was flushed with heparin in the usual manner. The patient did not receive systemic intravenous heparin. Tranexamic acid was administered intraoperatively during hemostasis. Please check the platelets, if necessary administer platelets or FFP, Hb controls and blood reserves if necessary. \ No newline at end of file diff --git a/156/InvasionFront_CD3_block13_x5_y6_patient156_0.json b/156/InvasionFront_CD3_block13_x5_y6_patient156_0.json new file mode 100644 index 0000000000000000000000000000000000000000..becc5a576c12a84553da5e5e5f2fb0fc83cae538 --- /dev/null +++ b/156/InvasionFront_CD3_block13_x5_y6_patient156_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 14317.4, + "Num Detections": 9145, + "Num Negative": 8364, + "Num Positive": 781, + "Positive %": 8.54, + "Num Positive per mm^2": 525.24 + } +} \ No newline at end of file diff --git a/156/InvasionFront_CD3_block13_x6_y6_patient156_1.json b/156/InvasionFront_CD3_block13_x6_y6_patient156_1.json new file mode 100644 index 0000000000000000000000000000000000000000..815d4cdcd34aeb3b950b06d900be4726368fdfc2 --- /dev/null +++ b/156/InvasionFront_CD3_block13_x6_y6_patient156_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 14117.5, + "Num Detections": 8940, + "Num Negative": 7463, + "Num Positive": 1477, + "Positive %": 16.52, + "Num Positive per mm^2": 1133.4 + } +} \ No newline at end of file diff --git a/156/InvasionFront_CD8_block13_x5_y6_patient156_0.json b/156/InvasionFront_CD8_block13_x5_y6_patient156_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42063ef0e8b5ec0c25961342b1dc64901112b2eb --- /dev/null +++ b/156/InvasionFront_CD8_block13_x5_y6_patient156_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17190.9, + "Centroid Y µm": 16241.4, + "Num Detections": 10800, + "Num Negative": 10557, + "Num Positive": 243, + "Positive %": 2.25, + "Num Positive per mm^2": 159.84 + } +} \ No newline at end of file diff --git a/156/InvasionFront_CD8_block13_x6_y6_patient156_1.json b/156/InvasionFront_CD8_block13_x6_y6_patient156_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5708b9fff99be00c85abe85e781038fd7298589d --- /dev/null +++ b/156/InvasionFront_CD8_block13_x6_y6_patient156_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19764.5, + "Centroid Y µm": 16216.4, + "Num Detections": 10894, + "Num Negative": 10415, + "Num Positive": 479, + "Positive %": 4.397, + "Num Positive per mm^2": 324.33 + } +} \ No newline at end of file diff --git a/156/TumorCenter_CD3_block13_x5_y6_patient156_0.json b/156/TumorCenter_CD3_block13_x5_y6_patient156_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d88e3c703e9682ec685336d0d106f32f631368c8 --- /dev/null +++ b/156/TumorCenter_CD3_block13_x5_y6_patient156_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16991.0, + "Centroid Y µm": 21688.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/156/TumorCenter_CD3_block13_x6_y6_patient156_1.json b/156/TumorCenter_CD3_block13_x6_y6_patient156_1.json new file mode 100644 index 0000000000000000000000000000000000000000..97f76884a53f30a4adabe36cde67270cc4cc579e --- /dev/null +++ b/156/TumorCenter_CD3_block13_x6_y6_patient156_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19539.7, + "Centroid Y µm": 21863.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/156/TumorCenter_CD8_block13_x5_y6_patient156_0.json b/156/TumorCenter_CD8_block13_x5_y6_patient156_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5f1042fcacc8ea693e683d8c33c3e7262a165e37 --- /dev/null +++ b/156/TumorCenter_CD8_block13_x5_y6_patient156_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16616.2, + "Centroid Y µm": 14467.3, + "Num Detections": 12301, + "Num Negative": 11711, + "Num Positive": 590, + "Positive %": 4.796, + "Num Positive per mm^2": 383.74 + } +} \ No newline at end of file diff --git a/156/TumorCenter_CD8_block13_x6_y6_patient156_1.json b/156/TumorCenter_CD8_block13_x6_y6_patient156_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9aa7bcbc4ed58cbfe2a7309622441cf973cf1ea8 --- /dev/null +++ b/156/TumorCenter_CD8_block13_x6_y6_patient156_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19214.8, + "Centroid Y µm": 14142.5, + "Num Detections": 7192, + "Num Negative": 6703, + "Num Positive": 489, + "Positive %": 6.799, + "Num Positive per mm^2": 567.75 + } +} \ No newline at end of file diff --git a/156/history_text.txt b/156/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..decc8acf1f39d634a0c0bb4c8d167e4f389f0cf6 --- /dev/null +++ b/156/history_text.txt @@ -0,0 +1 @@ +The patient had had a painful mass on the right edge of her tongue for some time, which was pre-biopsyed externally, revealing high-grade dysplasia, thus indicating the above-mentioned measures. \ No newline at end of file diff --git a/156/icd_codes.txt b/156/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dcb58fa629c23edc74b78b5a7dc38f102a8ed54e --- /dev/null +++ b/156/icd_codes.txt @@ -0,0 +1 @@ +Unsichere Neubildung des seitlichen Zungenrandes[D37.0 R] \ No newline at end of file diff --git a/156/ops_codes.txt b/156/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4dd7306cc909db1f710436d52619ee0b5de02610 --- /dev/null +++ b/156/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Epipharyngoskopie[1-611.0 ] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/156/patient_clinical_data.json b/156/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0de95ec04bfb9e0d13fbbcb05b405e474811d79f --- /dev/null +++ b/156/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 57, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 54, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/156/patient_pathological_data.json b/156/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4995708c775226f814622ff19725b31a288aae0f --- /dev/null +++ b/156/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "156", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 14.0 +} \ No newline at end of file diff --git a/156/surgery_description.txt b/156/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8a8b560d5d5f1764a525546e9c72b7c5cf32ae0b --- /dev/null +++ b/156/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy, Wound closure, Panendoscopy diff --git a/156/surgery_report.txt b/156/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..396578b870fb295010e511304211e75af953df9d --- /dev/null +++ b/156/surgery_report.txt @@ -0,0 +1 @@ +First induction of anaesthesia and intubation of the patient by the anaesthesia colleagues, then attention to the esophagogastroscopy with the flexible esophagogastroscope. Entering the stomach. The gastric mucosa up to the pylorus and with inversion including the cardia is non-irritating and inconspicuous. Careful retraction of the flexible esophagogastroscope under constant air insufflation, here too the mucosa is free of irritation on all sides throughout the esophagus. Insertion of a dental guard for the upper teeth and insertion with the Kleinsasser B-tube. The patient's jaw is slightly clamped, making it difficult to adjust overall. Otherwise, the mucosa in the oral cavity and oropharynx is free of irritation, the posterior pharyngeal wall, the base of the tongue, the tonsilloliths, the epiglottis, the vallecula and the lateral walls of the oropharynx with the glossotonsillar grooves are unremarkable on both sides. Even with further advancement of the small siphon tube, the mucosal conditions in the entire hypopharynx are inconspicuous, the piriform sinuses and the esophageal entrance can be freely unfolded and the postcricoid area is also inconspicuous, as are the interary area and the arytenoid cartilage. The glottis itself is difficult to adjust due to the jaw clamp and the teeth. As there are no further symptoms of discomfort or suspicion of a suspicious mass, no further measures are taken to avoid loosening the dentition. Now insertion of a McIvor mouth blocker and insertion of the velotractio on both sides. Inspection of the nasopharynx with a small mirror; the mucosal conditions are inconspicuous, the posterior edge of the vomer and the choanae and tubular bulges are visible. Removal of the mouth guard and velotractio and re-inspection and palpation of the oral cavity. A leukoplakia measuring approximately 1 ˝ cm x 7 mm can be seen in the area of the right posterior border of the tongue, which can be palpated with clear induration. The mass is excised with a scalpel and scissors and sent for histology with a suture marker. Finally, the bleeding is stopped. There is quite a lot of bleeding here, possibly from an arterial vessel. This is punctured several times, the lingual nerve is not visible macroscopically. Final hemostasis with the bipolar and, due to the gaping wound and the fairly heavy bleeding, the decision to suture the defect primarily using several back-stitch sutures. Once the bleeding had stopped completely and the wound edges had adapted, the operation was terminated. Further procedure after receipt of the final histology. \ No newline at end of file diff --git a/157/InvasionFront_CD3_block16_x5_y5_patient157_0.json b/157/InvasionFront_CD3_block16_x5_y5_patient157_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7a52e0c35b28b92206ecb231e82174cf5618625f --- /dev/null +++ b/157/InvasionFront_CD3_block16_x5_y5_patient157_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17086.2, + "Centroid Y µm": 17089.5, + "Num Detections": 17995, + "Num Negative": 15680, + "Num Positive": 2315, + "Positive %": 12.86, + "Num Positive per mm^2": 1089.1 + } +} \ No newline at end of file diff --git a/157/InvasionFront_CD3_block16_x6_y5_patient157_1.json b/157/InvasionFront_CD3_block16_x6_y5_patient157_1.json new file mode 100644 index 0000000000000000000000000000000000000000..80d59622b4fb1febcc5bd963e4ab63ba7b1c3a73 --- /dev/null +++ b/157/InvasionFront_CD3_block16_x6_y5_patient157_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19574.6, + "Centroid Y µm": 17190.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/157/InvasionFront_CD8_block16_x5_y5_patient157_0.json b/157/InvasionFront_CD8_block16_x5_y5_patient157_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0594a5788d1308cc3bc7e29ae8b007e649da79b0 --- /dev/null +++ b/157/InvasionFront_CD8_block16_x5_y5_patient157_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16374.7, + "Centroid Y µm": 12633.1, + "Num Detections": 19865, + "Num Negative": 18313, + "Num Positive": 1552, + "Positive %": 7.813, + "Num Positive per mm^2": 711.28 + } +} \ No newline at end of file diff --git a/157/InvasionFront_CD8_block16_x6_y5_patient157_1.json b/157/InvasionFront_CD8_block16_x6_y5_patient157_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8373e36d19f5b18ebc43dc8af37d79b47992d664 --- /dev/null +++ b/157/InvasionFront_CD8_block16_x6_y5_patient157_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18657.1, + "Centroid Y µm": 12587.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/157/TumorCenter_CD3_block16_x5_y5_patient157_0.json b/157/TumorCenter_CD3_block16_x5_y5_patient157_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aaea5840dbd60e352a4c2853b3c2d715cbd5c9a0 --- /dev/null +++ b/157/TumorCenter_CD3_block16_x5_y5_patient157_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16916.0, + "Centroid Y µm": 12918.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/157/TumorCenter_CD3_block16_x6_y5_patient157_1.json b/157/TumorCenter_CD3_block16_x6_y5_patient157_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0e92cfe45a1067ccdbb6d86c487b284ea4ab6e49 --- /dev/null +++ b/157/TumorCenter_CD3_block16_x6_y5_patient157_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19689.6, + "Centroid Y µm": 13068.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/157/TumorCenter_CD8_block16_x5_y5_patient157_0.json b/157/TumorCenter_CD8_block16_x5_y5_patient157_0.json new file mode 100644 index 0000000000000000000000000000000000000000..136b5f02773536af5b1b04e1fdccbb56b8c3c439 --- /dev/null +++ b/157/TumorCenter_CD8_block16_x5_y5_patient157_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 12993.1, + "Num Detections": 6585, + "Num Negative": 6301, + "Num Positive": 284, + "Positive %": 4.313, + "Num Positive per mm^2": 304.75 + } +} \ No newline at end of file diff --git a/157/TumorCenter_CD8_block16_x6_y5_patient157_1.json b/157/TumorCenter_CD8_block16_x6_y5_patient157_1.json new file mode 100644 index 0000000000000000000000000000000000000000..54ab788331f5292b900c885dd293c3ece7744aa6 --- /dev/null +++ b/157/TumorCenter_CD8_block16_x6_y5_patient157_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 12993.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/157/history_text.txt b/157/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4bd762df1c1f04d0a5453ad650927a714b239175 --- /dev/null +++ b/157/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT3 cN2b oral cavity/oropharyngeal carcinoma on the right was histologically confirmed during a panendoscopy. In a cN0 situation, our interdisciplinary tumor conference decided on primary surgical treatment with defect reconstruction. \ No newline at end of file diff --git a/157/icd_codes.txt b/157/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1889dce01fc125a8f29e77de1f1b85d8f1262bd4 --- /dev/null +++ b/157/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Mundrachenraums[C14.8 ] \ No newline at end of file diff --git a/157/ops_codes.txt b/157/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fafc8dedd18a4cf04d0fc2c0d4bfb479a0f829a3 --- /dev/null +++ b/157/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Entnahme eines freien Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-904.0e R] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Partielle Glossektomie durch Pharyngotomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.22 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/157/patient_clinical_data.json b/157/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0415b5aedaf4a274c5a36e939de45d334efb0a8c --- /dev/null +++ b/157/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/157/patient_pathological_data.json b/157/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b35dcb1f5ee30bbc3fb4a59e272de826f468ccd0 --- /dev/null +++ b/157/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "157", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/157/surgery_description.txt b/157/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..019d9de78bdb4a00ad2efb61639d02469a204484 --- /dev/null +++ b/157/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection diff --git a/157/surgery_report.txt b/157/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..85966eeb97051a123401fbaa34399be0a614fb94 --- /dev/null +++ b/157/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia with intubation and preparation of the patient by the anesthesia colleagues, the patient is first positioned. A pharyngoscopy is performed to determine the current extent of the tumor. An exulcerated tumor with infiltration of the lateral and posterior floor of the mouth with transition via the posterior floor of the mouth to the anterior palatal arch and circumscribed to the tonsillar lobe is found on the right edge of the tongue. The tumor grows submucosally from anterior to posterior in the area of the tongue margin, increasingly infiltrating and reaching approx. 1/3 of the extent in the area of the tongue base, in the area of the tongue base completely submucosal tumor growth. The vallecula, epiglottis and pharyngeal side walls are tumor-free. Therefore, first turn to transoral tumor resection. The tumor is cut around with the monopolar and later with the dissection technique, maintaining a safety margin of just under 1 cm in the mucosal area and 1.5 cm in the tongue area. In the area of the tongue muscles, widening of the safety margin. Resection of the soft palate section with removal of the tonsil lobe in the sense of a radical tonsillectomy. Retention of the posterior palatal arch and the uvula. Resection of the entire posterior floor of the mouth. The alveolar ridge is reached here, but no infiltration, therefore incision of the mucosa and detachment with the freer. After mobilization in the tongue area and removal at the mucosal level, it is now apparent that the tumour is clearly growing submandibularly and towards the base of the tongue. No complete transoral control here. Therefore, after complete release in the mucosal area except for the base of the tongue, turn to the transcervical approach to complete the tumor resection. Now reposition the patient. Skin incision on the anterior border of the sternocleidomastoid muscle on the right. Cut through skin and subcutaneous tissue. Exposure and dissection of the platysma. Dissection of the platysma. Exposure and preservation of the external jugular vein. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Level II shows a coarse, extensive and infiltrative growing metastasis, which was seen with clear infiltration of the muscle when the sternocleidomastoid muscle was dissected. The sternocleidomastoid muscle was therefore removed caudally at the level of the omohyoid muscle. Exposure and free dissection of the internal jugular vein, after cranial dissection removal of level V with careful protection of the cervical plexus branches. Free dissection of the internal jugular vein up to above the exit of the superior thyroid vein. This shows clear infiltration by the metastasis. There is also infiltration of the accessorius nerve. Deposition of the internal jugular vein above the aforementioned thyroid vein. Separation of the accessorius nerve and removal of the accessorius triangle. Exposure and dissection of the common carotid artery with bulb. Here the metastasis pulls hard on it, infiltrates the hypoglossal nerve, which must be removed, as well as direct contact with the ascending pharyngeal artery and occipital artery, both of which are also removed after ligation; later the lingual artery and facial artery are also ligated and removed. Resection of the metastasis as well as in toto, after removal in the case of circumscribed infiltration, of the digastric muscle. Free dissection of the carotid branches. The anterior neck preparation was removed while preserving the superior thyroid artery. Extirpation of the submandibular gland and thus also basal removal of the floor of the mouth. Evacuation of level I b with careful preservation and exposure of the ramus marginalis mandibulae. Several nodules here. Extension of the pharyngotomy dorsally. Completion and visualization of the resection area via both access routes. Checking the entrance in the area of the pharyngotomy. This is at a clear safety distance from the tumor. Good overview now. Resection and removal on the side wall of the pharynx and resection of the tumor with removal of a good 1/3 of the base of the tongue with macroscopic resection as far as in sano. Previously, completely covering marginal samples were taken in the area of the enoral margins. Completion of the transcervical margin samples in the area of the base of the tongue and the pharyngeal side wall. These are completely assessed as tumor- and dysplasia-free in frozen section diagnostics. Therefore, an R0 resection can now be assumed for completely imaged margin samples. This results in a wide pharyngeal defect. Measurement of the pharyngeal defect and design of the flap format. Based on the tongue resection, the decision is now made to remove a transfemoral graft. At the same time, the neck is dissected on the left side. Neck dissection. Skin incision on the front edge of the sternocleidomastoid muscle. Separation of skin and subcutaneous tissue. Exposure and dissection of the platysma. Exposure of the sternocleidomastoid muscle, omohyoid muscle, exposure of the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the cervical artery, the superior thyroid artery, the facial vein and the hypoglossal nerve. Free preparation of the internal jugular vein. Clearing of level V with careful protection of the cervical plexus branches and the cervical artery. Subsequent evacuation of the accessorius triangle with careful protection and exposure of the nerve. Followed by careful wound inspection and, if the wound is dry, wound irrigation. Insertion of a 10 Redon drain and careful, two-layer wound closure. Elevation of the transfemoral graft. After marking the orientation marks and identifying the intermuscular septum, the skin perforators are now identified using Doppler sonography. This is extremely laborious. It is only possible to identify a small perforator in the mid-thigh area using Doppler sonography. Decision for exploration. Marking of the graft. This is specially configured for the base of the tongue and soft palate, with a total length of 15 cm and a width of up to 6 cm. Medial incision. Cutting through skin and subcutaneous tissue. Dissection of the thigh fascia. Expose and secure the rectus femoris muscle. Now inspect the intermuscular septum. It can be seen that there is no perforator in the intermuscular septum between the vastus lateralis and the rectus femoris. However, from the septum, between the intermedius and the lateral vastus, a perforator can be seen entering the graft at an identified point; with very strong vessels of the lateral femoral artery medially, the decision is now made to explore the perforator with the possibility of a perforator flap if necessary. Tracing of the slender perforator after tracing under the intermedius muscle. Rapid increase in perforator thickness with opening into the extremely strong vascular pedicle. Therefore complete dissolution of the intermedius muscle. Identification and dissection of a further, even smaller perforator. Complete release from the muscle and thus preparation of a perforator flap. Isolation of the graft on the vascular pedicle and placement of the vital graft, also isolation on a strong artery and vein. Careful wound inspection and irrigation. Then insertion of a 10 Redon drain and careful, multi-layer wound closure with resection of excess skin. The graft is then inserted. This is done transorally and transcervically. Overall good fit with complete coverage of the defect. Upon insertion, the left canine tooth is loose, with an overall marod tooth status. This was extirpated. However, further inspection reveals a tooth status with several loose teeth that is in great need of restoration. Insertion of the graft. Dense conditions on all sides. Therefore, conditioning of the neck vessels on the right for anastomosis. Conditioning of the superior thyroid artery and the superior thyroid vein, which has excellent flow through the caudally preserved internal jugular vein. Conditioning of the flap vessels. Perform the arterial anastomosis with 8-0 Ethilon. This is successful and immediately sufficient. Tight conditions in the area of the anastomosis and immediate regular venous return. Therefore conditioning of the superior thyroid vein. Measurement of a size 4-0 coupler and easy passage of the venous anastomosis with the coupler system. Subsequently, regular circulation and pulsation with excellent graft perfusion. Therefore, after final wound inspection, insertion of a guided 10 Redon drain and subsequent careful, two-layer wound closure. The tracheotomy was performed at the same time. For this, a skin incision was made approx. 1 cm below the cricoid cartilage. Cut through the skin and subcutaneous tissue. Exposure and splitting of the infrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björk flap and incision of the tracheostoma with mucocutaneous anastomosis. Subsequent problem-free intubation onto a size 8 low-cuff cannula, which is suture-fixed. Final inspection. Vital graft. Repositioning of the patient and completion of the procedure without any indication of complications. Conclusion: Intraoperative R0 resected cT3 cN2c oral cavity/oropharyngeal carcinoma. Complex reconstruction due to the anatomical conditions, flap size and defect location. Extended radical neck dissection and tumor resection on the right with additional resection of the hypoglossal nerve and the lingual nerve. \ No newline at end of file diff --git a/158/InvasionFront_CD3_block6_x1_y12_patient158_0.json b/158/InvasionFront_CD3_block6_x1_y12_patient158_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5f1908bd867ed242d1082eebfa232131c7f4e694 --- /dev/null +++ b/158/InvasionFront_CD3_block6_x1_y12_patient158_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3448.2, + "Centroid Y µm": 30608.8, + "Num Detections": 25448, + "Num Negative": 15804, + "Num Positive": 9644, + "Positive %": 37.9, + "Num Positive per mm^2": 3507.6 + } +} \ No newline at end of file diff --git a/158/InvasionFront_CD3_block6_x2_y12_patient158_1.json b/158/InvasionFront_CD3_block6_x2_y12_patient158_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9b5c9abd729d79a82c4aa85cb405f46aa3b15d05 --- /dev/null +++ b/158/InvasionFront_CD3_block6_x2_y12_patient158_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 30807.1, + "Num Detections": 26454, + "Num Negative": 14176, + "Num Positive": 12278, + "Positive %": 46.41, + "Num Positive per mm^2": 4526.4 + } +} \ No newline at end of file diff --git a/158/InvasionFront_CD8_block6_x1_y10_patient158_0.json b/158/InvasionFront_CD8_block6_x1_y10_patient158_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ef8d0c2043bc22f0666dd860ad8e081e6ab1a601 --- /dev/null +++ b/158/InvasionFront_CD8_block6_x1_y10_patient158_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4047.9, + "Centroid Y µm": 24911.8, + "Num Detections": 22078, + "Num Negative": 20727, + "Num Positive": 1351, + "Positive %": 6.119, + "Num Positive per mm^2": 552.1 + } +} \ No newline at end of file diff --git a/158/InvasionFront_CD8_block6_x2_y10_patient158_1.json b/158/InvasionFront_CD8_block6_x2_y10_patient158_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d6c581c7f12b86bfcf5bab75df70fd6fe8e6d3a --- /dev/null +++ b/158/InvasionFront_CD8_block6_x2_y10_patient158_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6696.5, + "Centroid Y µm": 25036.7, + "Num Detections": 24139, + "Num Negative": 19228, + "Num Positive": 4911, + "Positive %": 20.34, + "Num Positive per mm^2": 1799.8 + } +} \ No newline at end of file diff --git a/158/TumorCenter_CD3_block6_x1_y10_patient158_0.json b/158/TumorCenter_CD3_block6_x1_y10_patient158_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2cbe79cffd881fac488d61b3cabe01842d937aef --- /dev/null +++ b/158/TumorCenter_CD3_block6_x1_y10_patient158_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4072.8, + "Centroid Y µm": 25661.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/158/TumorCenter_CD3_block6_x2_y10_patient158_1.json b/158/TumorCenter_CD3_block6_x2_y10_patient158_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a03b3d941eadc939a0b8e77310da14c9382b1441 --- /dev/null +++ b/158/TumorCenter_CD3_block6_x2_y10_patient158_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 25561.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/158/TumorCenter_CD8_block6_x1_y10_patient158_0.json b/158/TumorCenter_CD8_block6_x1_y10_patient158_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2599508078871feddcab9d6f681206ff8b3c852f --- /dev/null +++ b/158/TumorCenter_CD8_block6_x1_y10_patient158_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3848.0, + "Centroid Y µm": 26011.2, + "Num Detections": 16013, + "Num Negative": 15062, + "Num Positive": 951, + "Positive %": 5.939, + "Num Positive per mm^2": 490.91 + } +} \ No newline at end of file diff --git a/158/TumorCenter_CD8_block6_x2_y10_patient158_1.json b/158/TumorCenter_CD8_block6_x2_y10_patient158_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9f88a85c7faa25817d76e41f72d1aba3c6b8426b --- /dev/null +++ b/158/TumorCenter_CD8_block6_x2_y10_patient158_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 25786.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/158/history_text.txt b/158/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/158/icd_codes.txt b/158/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/158/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/158/ops_codes.txt b/158/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2699621d1f25412cec94000daf54a0332d2dd018 --- /dev/null +++ b/158/ops_codes.txt @@ -0,0 +1 @@ +Temporäre Tracheotomie[5-311.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 6 Regionen[5-403.12 L] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Sonstige radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.x4 ] Entnahme freier Radialis-Lappen[5-858.23 L] Transorale radikale Tonsillektomie [ohne Adenotomie][5-281.2 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] \ No newline at end of file diff --git a/158/patient_clinical_data.json b/158/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..374854edf733af47ad3cafd67cddc4f7b42487df --- /dev/null +++ b/158/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/158/patient_pathological_data.json b/158/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0b1e060de3d432908e7f11804a1ebebfd48d8f6e --- /dev/null +++ b/158/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "158", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 15.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/158/surgery_description.txt b/158/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..99ea4f97d7c834aa7693445a0a32c71188cfc360 --- /dev/null +++ b/158/surgery_description.txt @@ -0,0 +1 @@ +Resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheostomy, PEG placement diff --git a/158/surgery_report.txt b/158/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..80613e410e984f93d0cdaab2e018cf02fc93c001 --- /dev/null +++ b/158/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first insertion of the PEG tube through and in the usual way. Subsequently, transition to transoral tumor resection. After adjusting the oropharynx with the tonsil retractor, a somewhat uneven mucosa can be seen in the area of the left tonsil. An exophytic or easily palpable tumor is not visible. If a caudal view of the lateral pharyngeal wall is possible with the retractor, a caudal tissue sample is taken to determine the extent of the carcinoma, which is not clearly visible. This sample proves positive in the frozen section histological diagnosis. Then start with monopolar tumor resection on the left side. The entire tonsil lobe is resected successively, starting at the parauvular left upper tonsil pole and removing the left anterior palatine arch and the adjacent posterior palatine arch with transition to the medial posterior hypopharyngeal wall. The entire musculature up to the soft tissues of the neck and the adjacent vessels is successively resected caudally. About 3/4 of the tumor is developed transorally downwards as far as possible. Subsequently, marginal sections are removed from the posterior wall of the hypopharynx, from the upper tonsil pole and from the lateral margin. Isolated tumor cell nests can still be found caudally in the area of the lateral margin, the remaining resected sections are tumor-free. Further excision will then be performed transcervically after completion of the neck dissection. Transition to neck dissection on the left side. A large fixed metastasis can already be palpated at the junction of regions II and III. After skin incision, dissection of the skin platysma flap laterally. The platysma is incised over the metastasis so that the skin can finally be moved laterally. Locate the vascular nerve sheath under the omohyoid muscle caudally. Trace the omohyoid muscle ventrally upwards. Then expose the anterior belly of the digastric muscle. Also expose the posterior belly of the digastric muscle. It can now be seen that the entire tumor block has even reached the caudal submandibular gland. Therefore, this is first removed by dissecting the facial vein and the facial artery while identifying and protecting the lingual nerve. In this way, the tumor block can be successively developed laterally starting at the submandibular gland while exposing and sparing the hypoglossal nerve. The external carotid artery, the carotid bifurcation and the common carotid artery are then exposed and released. The internal jugular vein is completely infiltrated, as are the sternocleidomastoid muscle and the accessorius nerve. Therefore, the internal jugular vein is deposited under the posterior belly of the digastric muscle after it has been found at the base of the skull. The internal jugular vein is also removed caudally in the area at the level of the clavicle. Dissection of the large tumor block and removal of the insertion of the sternocleidomastoid muscle at the tip of the mastoid. It is now apparent that the entire neck is full of hard nodular metastases down to the depth of the brachial plexus. The resection is therefore carried out as extensively as necessary and possible. The entire tumor block is successively resected radically, resecting all branches of the cervical plexus. Follow the tumor masses caudally, exposing and skeletonizing the phrenic nerve. The last metastasis is dissected free from the subclavian vein under traction. This leaves only the common carotid artery, the vagus nerve and the hypoglossal nerve on the left neck. Then widening of the opening in the neck and disluxation of the partially resected tumor. Then complete the tumor resection with parts of the base of the tongue and the remaining lateral to ................................. margin. This shows that the tumor has in principle grown through the lateral pharyngeal wall per continuitatem to the external carotid artery and can be detached from this in a healthy layer. After resection of an extensive section of the base of the tongue, as it is also affected by frozen section histology, all marginal sections of the base of the tongue as well as the remaining caudal and lateral hypopharyngeal wall are then tumor-free. Subsequent transition to elevation of the radial lobe graft by and . Palpatory identification of the distal radial artery. Marking of the flap borders (13 cm x 5.5 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Covering of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Now transition to neck dissection on the right side. Here, regions I-V are also selectively removed while preserving all lymphatic structures. Here too, a large lymph node metastasis is found in region II. The facial artery is then dissected beyond the lower jaw so that it can later be used for anastomosis. The V. facialis is also dissected as far beyond the mandible as possible while sparing the ramus marginalis mandibulae and cut caudally. After removal of the radialis graft, it is first sutured transcervically in the area of the base of the tongue and the caudal lateral hypopharyngeal wall at the level of the epiglottis and the vallecula. The remaining sutures are then performed transorally. After creating a transition to the opposite side, the flap pedicle is then transferred to the opposite side at the level of the hyoid. Here the arterial anastomosis of the radial artery to the facial artery is performed. The venous outflow is connected to the facial vein in an end-to-side manner via a vein in the flap. The 2nd humeral vein has a corresponding length so that it can be connected to the internal jugular vein on the right side in an end-to-side manner. A Redon suction drain and a drainage flap are then placed on the right side. Multi-layer wound closure. Completion of the mucocutaneous anastomosis of the tracheostoma. Re-intubation of the patient. End of the operation, transfer of the patient to anesthesia. Conclusion: Resection of a tonsillar carcinoma on the left side cT3 with radical neck dissection on the left and selective neck dissection region I-V on the right side. Reconstruction with a microvascularly anastomosed radial flap from the left forearm, which is inserted into the orohypopharyngeal defect on the left side and whose stalk is anastomosed to the right vascular nerve sheath. Due to the extensive tumor findings, adjuvant radiochemotherapy is strongly recommended. \ No newline at end of file diff --git a/159/InvasionFront_CD3_block4_x5_y5_patient159_0.json b/159/InvasionFront_CD3_block4_x5_y5_patient159_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ae8f6e8bcfb6caaf0f6428eb1d660089d2adf7ab --- /dev/null +++ b/159/InvasionFront_CD3_block4_x5_y5_patient159_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 18815.0, + "Num Detections": 22243, + "Num Negative": 19593, + "Num Positive": 2650, + "Positive %": 11.91, + "Num Positive per mm^2": 1113.0 + } +} \ No newline at end of file diff --git a/159/InvasionFront_CD3_block4_x6_y5_patient159_1.json b/159/InvasionFront_CD3_block4_x6_y5_patient159_1.json new file mode 100644 index 0000000000000000000000000000000000000000..01bd21913b3838f83c815158cf3e87c2ba86bf6b --- /dev/null +++ b/159/InvasionFront_CD3_block4_x6_y5_patient159_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21538.6, + "Centroid Y µm": 18890.0, + "Num Detections": 22266, + "Num Negative": 19362, + "Num Positive": 2904, + "Positive %": 13.04, + "Num Positive per mm^2": 1188.3 + } +} \ No newline at end of file diff --git a/159/InvasionFront_CD8_block4_x5_y5_patient159_0.json b/159/InvasionFront_CD8_block4_x5_y5_patient159_0.json new file mode 100644 index 0000000000000000000000000000000000000000..113c9b7e047672224d17ea44148920713b011c49 --- /dev/null +++ b/159/InvasionFront_CD8_block4_x5_y5_patient159_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 17415.8, + "Num Detections": 21250, + "Num Negative": 18603, + "Num Positive": 2647, + "Positive %": 12.46, + "Num Positive per mm^2": 1098.4 + } +} \ No newline at end of file diff --git a/159/InvasionFront_CD8_block4_x6_y5_patient159_1.json b/159/InvasionFront_CD8_block4_x6_y5_patient159_1.json new file mode 100644 index 0000000000000000000000000000000000000000..23bc035ddeaa99ef3bbe8cccec837136cfbd1eb0 --- /dev/null +++ b/159/InvasionFront_CD8_block4_x6_y5_patient159_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 17540.7, + "Num Detections": 21648, + "Num Negative": 19438, + "Num Positive": 2210, + "Positive %": 10.21, + "Num Positive per mm^2": 897.42 + } +} \ No newline at end of file diff --git a/159/TumorCenter_CD3_block4_x5_y5_patient159_0.json b/159/TumorCenter_CD3_block4_x5_y5_patient159_0.json new file mode 100644 index 0000000000000000000000000000000000000000..885f6f189897ae2c45f6a9cbcda10de013aae67e --- /dev/null +++ b/159/TumorCenter_CD3_block4_x5_y5_patient159_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16166.4, + "Centroid Y µm": 12893.2, + "Num Detections": 26756, + "Num Negative": 24636, + "Num Positive": 2120, + "Positive %": 7.923, + "Num Positive per mm^2": 835.38 + } +} \ No newline at end of file diff --git a/159/TumorCenter_CD3_block4_x6_y5_patient159_1.json b/159/TumorCenter_CD3_block4_x6_y5_patient159_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5d00369c188d02ac66a2f1c166b391b78be9352c --- /dev/null +++ b/159/TumorCenter_CD3_block4_x6_y5_patient159_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 12918.2, + "Num Detections": 21664, + "Num Negative": 19378, + "Num Positive": 2286, + "Positive %": 10.55, + "Num Positive per mm^2": 958.3 + } +} \ No newline at end of file diff --git a/159/TumorCenter_CD8_block4_x5_y5_patient159_0.json b/159/TumorCenter_CD8_block4_x5_y5_patient159_0.json new file mode 100644 index 0000000000000000000000000000000000000000..facb387b1fbe080be085bf5c23949ca677cab839 --- /dev/null +++ b/159/TumorCenter_CD8_block4_x5_y5_patient159_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16866.1, + "Centroid Y µm": 12943.1, + "Num Detections": 27771, + "Num Negative": 26608, + "Num Positive": 1163, + "Positive %": 4.188, + "Num Positive per mm^2": 455.99 + } +} \ No newline at end of file diff --git a/159/TumorCenter_CD8_block4_x6_y5_patient159_1.json b/159/TumorCenter_CD8_block4_x6_y5_patient159_1.json new file mode 100644 index 0000000000000000000000000000000000000000..482c5fe21d29ea349e60ee5116ef64ff087d3f30 --- /dev/null +++ b/159/TumorCenter_CD8_block4_x6_y5_patient159_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19364.7, + "Centroid Y µm": 13093.1, + "Num Detections": 22724, + "Num Negative": 21804, + "Num Positive": 920, + "Positive %": 4.049, + "Num Positive per mm^2": 381.84 + } +} \ No newline at end of file diff --git a/159/history_text.txt b/159/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/159/icd_codes.txt b/159/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..613eb1afc3306e488b6b208c5d5387f6fe5633cb --- /dev/null +++ b/159/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx Seitenwand[C10.2 R] Neubildung bösartig sekundär und onA Lymphknoten Kopf Gesicht Hals[C77.0 R] \ No newline at end of file diff --git a/159/ops_codes.txt b/159/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0a1e2942970dc5a2cf44b338cb95cf285947798f --- /dev/null +++ b/159/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision Wange[5-273.4 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Entnahme eines freien Lappens am Unterarm mit mikrovaskulärer Anastomosierung[5-904.08 L] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Transorale Tumortonsillektomie[5-281.2 ] Zungenteilresektion onA[5-251.y ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/159/patient_clinical_data.json b/159/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8c852f5580095d0dc0a95a5d296f4683bd0d4048 --- /dev/null +++ b/159/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/159/patient_pathological_data.json b/159/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..167f47becd540c59d31b6964a22be8a6155a9996 --- /dev/null +++ b/159/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "159", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 64, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/159/surgery_report.txt b/159/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e5125c5b958b07879ac5a7a7448bf6d1132e2cd0 --- /dev/null +++ b/159/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and transnasal intubation by anesthesia colleagues. PEG insertion: insertion of the esophagoscope into the stomach. No abnormalities found during a thorough examination. After diaphanoscopy, insertion of a 15 mm abdominal wall tube in a typical manner without complications. Fixation to the abdominal wall in the typical manner. Entry with the Kleinsasser tube and inspection of the tumor region. Insertion of the McIVOR oral spatula and inspection of the tumor region. The tumor starts on the soft palate parauvularly on the right and extends over the tonsillar lobe to the base of the tongue, it also grows into the edge of the tongue on the right side. Now sterile washing and draping. Start with transoral tumor resection. Here the operation is performed with an electric needle and partly with scissors and bipolar forceps. In the area of the base of the tongue, the overview is so difficult that it is no longer possible to operate transorally. Now create an apron flap and expose the sternocleidomastoid muscle, omohyoid muscle and submandibular gland. Exposure of the cervical vascular sheath and exposure of the hyoid bone and continuation of the tumor resection from transcervical. To do this, the digastric muscle must be cut and the tumor must be luted through from transoral to cervical. Then successively cut around the tumor in the tongue base area so that the tumor can be completely resected en bloc with a safety margin of 1.5 cm. The tumor preparation is placed on cork and marked as a whole for frozen section. All tumor margins are assessed as free. Now complete the neck dissection on the right side. For this, free preparation of the internal jugular vein, the facial vein and the external jugular vein. There are several large metastases in level II a and b. Part of the cervical plexus must also be removed as the metastases are fused to it and the accessorius cannot be preserved either. The border cord of the vagus nerve and the hypoglossal nerve can be preserved. Then send in the neck dissection level individually as part of the lymph node study. On the opposite side, neck dissection by . The sternocleidomastoid muscle is also visualized for this. Exposure of the omohyoid muscle and the submandibular gland. Dissection of the internal jugular vein. Exposure of the hypoglossal nerve, the accessorius nerve and clearing of the neck levels II a to V a while sparing the plexus branches. The neck levels are also sent in individually as part of the lymph node study. Repositioning for tracheotomy. Perform a visor tracheotomy between the second and third tracheal cartilage through and create a mucocutaneous anastomosis. Lifting of the radialis graft by and . Parallel to this, lift the split skin from the right thigh with the dermatome 7.5 mm. Then dissection of the neck vessels under the microscope on the right side. The external jugular vein, the facial vein with one outlet and the superior thyroid artery are dissected. The lingual artery was resected as part of the tumor resection and is dissected as a stump for the anastomosis. Then transfer of the operation to . Elevation of the radialis graft: Marking of the graft (6 x 11 cm) on the distal forearm. Incision of the graft and transection of the cutaneous and subcutaneous tissue and the forearm fascia. Exposure of the confluence in the crook of the elbow and dissection along the cephalic vein to the radial flap edge. Integration of the cephalic vein into the graft. Raise the cephalic vein and expose the external ramus of the radial nerve. Ulnar preparation subfascially up to the flexor carpi radialis muscle. Locate the distal stump of the radial artery. Undermining with a clamp and clamping of the radial artery. A good perfusion signal can be recorded the entire time. Dissection of the radial artery and ligation of the stumps. Elevation of the radial artery flap from the wound bed, with constant bipolar coagulation of smaller vessels and placement of vascular clips. This is done while protecting the radial nerve. Dissection of the blood vessels in the crook of the elbow and removal of the flap, first of the artery and then of the vein. Lifting of the graft without complications. Wound closure using split skin from the lower leg by . Then insertion of the radial flap: The radial flap is inserted into the defect and successively sutured into the defect both transcervically and transorally, partly with the sutures in place. This is achieved without tension using 3-0 Vicryl single-button sutures followed by dissection of the superior thyroid artery and an outlet from the internal jugular vein as well as dissection of the external jugular vein. All vessels are conditioned for vascular anastomosis. After conditioning the radial artery anastomosis, this is then connected to the superior thyroid artery. After opening the clamps, good arterial flow, good venous return. Then conditioning of the cephalic veins. One is anastomosed with the external jugular vein using a 3.5 mm vessel coupler. After opening the clamps, good venous return, positive smear phenomenon. The second smaller part of the superficial venous outflow is anastomosed with the outlet from the internal jugular vein using a 2-0 coupler. Here too, good venous return after opening the clamps. Positive smear phenomenon. A small outlet, which corresponds to the confluence, is clipped. Subsequent careful hemostasis. Inspection of the flap shows good perfusion. Extensive irrigation and hemostasis. Wound closure in layers and epithelialization of the tracheostoma, insertion of a Redon drain on the left and 2 flaps on the right. The forearm was treated in the typical manner with a Mepilex swab dressing and fixed and attached to a Cramer splint. A hydrogel dressing was applied to the thigh area. The tracheostomy tube was fixed with sutures. The procedure was completed without complications. The patient was admitted to the intensive care unit for postoperative monitoring. Please continue the antibiotic treatment started intraoperatively for approx. 1 week. Nutrition via the inserted PEG tube for 7-10 days. Then gruel and, if necessary, build up the diet. Monitoring of the flap for 5 days by Doppler or clinically. Heparin 500 E/h as a perfusor for 5 days. After receiving the final histology, presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/160/InvasionFront_CD3_block16_x3_y11_patient160_0.json b/160/InvasionFront_CD3_block16_x3_y11_patient160_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d6e881d75f0eeda74453659be3742a6a57215375 --- /dev/null +++ b/160/InvasionFront_CD3_block16_x3_y11_patient160_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11560.5, + "Centroid Y µm": 31888.1, + "Num Detections": 17373, + "Num Negative": 16984, + "Num Positive": 389, + "Positive %": 2.239, + "Num Positive per mm^2": 180.39 + } +} \ No newline at end of file diff --git a/160/TumorCenter_CD3_block16_x3_y12_patient160_0.json b/160/TumorCenter_CD3_block16_x3_y12_patient160_0.json new file mode 100644 index 0000000000000000000000000000000000000000..89aa56520f86ebaa9b5ed96e32b9530f10f8102d --- /dev/null +++ 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