diff --git a/194/InvasionFront_CD8_block9_x4_y6_patient194_1.json b/194/InvasionFront_CD8_block9_x4_y6_patient194_1.json new file mode 100644 index 0000000000000000000000000000000000000000..30573d4f06c4722dad15183aa277b5743b389673 --- /dev/null +++ b/194/InvasionFront_CD8_block9_x4_y6_patient194_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15216.9, + "Centroid Y µm": 19639.6, + "Num Detections": 20921, + "Num Negative": 19376, + "Num Positive": 1545, + "Positive %": 7.385, + "Num Positive per mm^2": 610.18 + } +} \ No newline at end of file diff --git a/194/TumorCenter_CD3_block9_x4_y6_patient194_1.json b/194/TumorCenter_CD3_block9_x4_y6_patient194_1.json new file mode 100644 index 0000000000000000000000000000000000000000..43f7f51c8d7b40faca2458e081b73030a5e5130c --- /dev/null +++ b/194/TumorCenter_CD3_block9_x4_y6_patient194_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 20739.0, + "Num Detections": 18012, + "Num Negative": 16338, + "Num Positive": 1674, + "Positive %": 9.294, + "Num Positive per mm^2": 698.02 + } +} \ No newline at end of file diff --git a/194/TumorCenter_CD8_block9_x3_y6_patient194_0.json b/194/TumorCenter_CD8_block9_x3_y6_patient194_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d0bb6be8bb7a61e8c2b5d3d0c44c8c9c0275a148 --- /dev/null +++ b/194/TumorCenter_CD8_block9_x3_y6_patient194_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 15966.5, + "Num Detections": 18747, + "Num Negative": 17515, + "Num Positive": 1232, + "Positive %": 6.572, + "Num Positive per mm^2": 545.04 + } +} \ No newline at end of file diff --git a/194/TumorCenter_CD8_block9_x4_y6_patient194_1.json b/194/TumorCenter_CD8_block9_x4_y6_patient194_1.json new file mode 100644 index 0000000000000000000000000000000000000000..00230d992a4b84584f8ddbffab045a055668a1a0 --- /dev/null +++ b/194/TumorCenter_CD8_block9_x4_y6_patient194_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 15854.1, + "Num Detections": 17219, + "Num Negative": 16619, + "Num Positive": 600, + "Positive %": 3.485, + "Num Positive per mm^2": 287.46 + } +} \ No newline at end of file diff --git a/194/history_text.txt b/194/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d3939995cfc62b9c557e88f8ddaa2989dac925c6 --- /dev/null +++ b/194/history_text.txt @@ -0,0 +1 @@ +Patient with post-treatment rhabdomyosarcoma in childhood including radiochemotherapy, radiation dose up to 71 Gy. Now tongue base carcinoma, histologically squamous cell carcinoma on the left, extending to the midline. Second tumor after radiotherapy in childhood. Therefore above mentioned surgery indicated. \ No newline at end of file diff --git a/194/icd_codes.txt b/194/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ae555e4e3613cb40832e33820e0beb0d9451a2ca --- /dev/null +++ b/194/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] Bösartige Neubildung Lippe Mundhöhle Pharynx mehrere Teilbereiche überlappend[C14.8 ] Bösartige Neubildung der Übergangsregion des Oropharynx[C10.8 L] \ No newline at end of file diff --git a/194/ops_codes.txt b/194/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d616e0483db0a67bf20a74d4de4456c6f859a98b --- /dev/null +++ b/194/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Sonstige radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.x4 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Pharyngoplastik mit mikrovaskulär anastomosiertem Transplantat[5-293.2 ] Partielle Resektion der Zunge durch Pharyngotomie mit Rekonstruktion mit nicht vaskularisiertem Transplantat[5-251.21 ] Temporäre Tracheotomie[5-311.0 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Sonstige partielle Laryngektomie[5-302.x ] \ No newline at end of file diff --git a/194/patient_clinical_data.json b/194/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4e1da7dcd7f6c452727a3b566be58d28f49074d4 --- /dev/null +++ b/194/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 34, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 53, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/194/patient_pathological_data.json b/194/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..61598a4b55e3118c7bc2eefc316eb2b7d3e1eb4e --- /dev/null +++ b/194/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "194", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/194/surgery_description.txt b/194/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..54129398d648eb6ab323c054f97c9731b994482b --- /dev/null +++ b/194/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, Free flap (Radial), Tracheotomy diff --git a/194/surgery_report.txt b/194/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..097f232de4670f85e033b3af9987382b1ed36106 --- /dev/null +++ b/194/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy/laryngoscopy again and confirmation of the extent. The tumor is located in the base of the tongue on the left, reaching at least to the midline. The tumor extends to the glossotonsillar groove or the tonsil. This confirms the indication for surgery with flap coverage. First PEG placement: insertion of the flexible esophagoscope into the stomach. There, after creating the diaphanoscopy, insertion of a 15 mm stomach wall tube without complications. Sterile dressing. Subsequent repositioning for tumor resection and flap covering: First skin disinfection and injection of a total of 15 ml Ultracaine with adrenaline into the area of the planned apron flap and sterile covering of all surgical areas. Start with dissection of the apron flap: This is performed via the typical skin incision and by elevating the tissue subplatysmal to the level of the hyoid bone or submandibular gland. Subsequent neck dissection on the left: Exposure of the sternocleidomastoid muscle, digastric muscle and omohyoid muscle. Exposure of the infrahyoid muscles. Depiction of the common, internal and external carotid artery, internal jugular vein and facial vein. An external jugular vein is only very thin and is coagulated. The auricular nerve is exposed and preserved. Exposure of the hypoglossal nerve, vagus nerve, cervical nerve and accessorius nerve. Clearing level II to V a, with preservation of the cervical plexus. Subsequent combined tumor resection: start transorally. Tumor is palpated. Cut around the tumor with a distance of at least 1.5 cm on all sides. Resection extends beyond the midline. Resection includes the floor of the mouth, the lingual nerve is initially exposed, but must be resected later due to its proximity to the tumor. Mucosa is resected up to the alveolar ridge along the glossoalveolar groove. Lower parts of the tonsil are resected together with parts of the caudal palatal arch. Counter-operation from the transcervical side to resect the tumor in the base of the tongue while sparing the lingualis on the opposite side. Resection is performed with exposure of the lingual artery on the right side. Resection is performed in the vallecula to the left, taking the mucosa of the lingual epiglottis with it. Resection extends to the piriform sinus entrance. Cranially again up to the lower part of the palatal arch. The specimen is removed and thread-marked. An additional marginal sample is taken from the glossotonsillar groove from the floor of the mouth to the alveolar ridge to the lower edge of the tonsil. This is also thread-marked for the frozen section. In the frozen section, the tumor is basically removed on all sides in healthy tissue, but slightly higher-grade, approximately medium-grade dysplasia caudally in the direction of the vallecula, higher-grade dysplasia cannot be ruled out with certainty. Therefore resection is recommended again. An approx. 1 cm wide strip is resected, including the lateral parts of the epiglottis, the entrance of the piriform sinus up to the posterior pharyngeal wall. This goes to the frozen section marked with a thread remote from the tumor. Confirmation that this marginal sample is tumor-free at the markings remote from the tumor. Thus overall R0 resection with regard to the primary. There is now a defect in the area of the vallecula and pharyngeal side wall up to the tonsil lobe as well as in the floor of the mouth and in particular in the body and base of the tongue. Radial flap is planned after measuring the required three-dimensional dimensions. Neck dissection on the right: This neck dissection is performed in the same way as on the left side. Here too, clearing of levels II to V a. Then tracheotomy: After cutting through the thyroid isthmus and supplying it with puncture ligatures, visualization of the trachea. Entry into the trachea and creation of a broadly pedicled, visor-like, modified Björk flap. This is initially epithelized caudally. Insertion of a laryngectomy tube. Now remove the radial flap from the left forearm: mark the flap in the required three-dimensional size. Maximum length 11 cm, maximum width 7 ˝ cm. First cut around the flap ulnarly and lift subfascially. Then extend the incision into the crook of the elbow. Exposure of the superficial venous system. Only obliterated residual veins are visible here, with an insignificant volume, but still connected to the deep venous system. Visualization of the vascular pedicle. This shows a larger radial vein after confluence. Now first elevation of the superficial venous system from subfascial. Dissection of the radialis flap now from the radial side and elevation from the radial side. Exposure and preservation of the lateral antebrachial cutaneous nerve. Caudal exposure of the radial artery. After clamping and sufficient waiting time, always 100% saturation. Deposition of the radial artery. The artery is treated with 4-0 Prolene stitches. Lift the radial artery flap with the pedicle subfascially along the course of the pedicle. Outgoing, smaller vessels are clipped or treated with bipolar coagulation. In the antecubital fossa, the relatively small radial artery is exposed as far as the entrance to the brachial artery. The confluence can be followed a little further into the antecubital fossa. The flap is then removed. The small, rudimentary cephalic veins are also removed and ligated proximally. The relatively thin radial artery is supplied twice using a clip. The confluent radial vein is ligated after removal. Flush the flap with heparin solution. Subsequent insertion of the flap. This is generally very difficult due to the very narrow mouth opening. The flap is successively worked into the defect with 3-0 Vicryl single button sutures according to the preforming. Difficult suturing due to the limited space available. Finally, the flap is sutured in all dimensions sufficiently. Tension-free, complete closure. The stalk is carried forward into the left side of the neck. The connecting vessels are then shown here. The superior artery and the facial vein are selected first. Conditioning of the superior thyroid artery and the radial artery. Suture with 9-0 Ethilon single-button sutures. After opening the clamp, initially very good blood flow and good venous return. Insufficient pulsation in the course, possible vascular spasm or thrombosis. Therefore opening of the superior thyroid artery. No blood flow recognizable here, even after dilatation. Either spasm or thrombosis near the outlet. Closure of the superior thyroid artery with clips, as was previously done in the distal area of this artery. Additional ligation. Subsequent exploration of the linguofacial trunk. The facial artery, which was previously preserved, is already thrombosed. Overall, the relatively poor vascular status after chemotherapy was confirmed. The lingual artery can be visualized, the ligature is removed and the artery is shortened. Afterwards, there is good blood flow from this artery. Therefore, the radial artery is now reapproximated to the lingual artery. This is done with 9-0 Ethilon single button sutures. Again, good arterial flow and also good venous return. Therefore, the veins are now conditioned. The facial vein is conditioned with confluence of the radial vein. Selection of a coupler size 2.5 and anastomosis of the veins without any problems. Good venous return. Subsequent irrigation of the entire wound area. Careful hemostasis. Successive wound closure with insertion of a flap on the left and a Redon drainage on the right and epithelialization of the tracheostoma. Suture marking in the area of the vascular pedicle for sonographic Doppler control. The flap is then checked again. This shows that there is no blood flow after the puncture. This means that there is again insufficient perfusion via the arterial vessel. The wound must therefore be reopened on the left side. Visualization of the pedicle. Here, too, there is no longer any continuous pulsation, which means that there is another thrombosis. Opening of the artery. No sufficient blood flow recognizable here, similar to the superior thyroid artery previously. Thus, again suspected thrombosis or vasospasm. Even after dilatation, there is no longer sufficient blood flow from this vessel. The flap is flushed with heparin solution until it comes out of the venous vascular system and is recognizable again. Shortening of the vessel in the area of the linguofacial trunk. Very good blood flow here again. The radial artery is dissected like a fish mouth and anastomosed again with the now significantly larger lumen using 9-0 Ethilon single button sutures. Again, after opening the clamp, good blood flow, good venous return. Now follow the perfusion for approx. 1 hour. Here finally permanent arterial pulsation, which also provides signals with the Doppler, in contrast to the previous anastomoses. Puncture of the flap shows good perfusion. This time the anastomosis appears to remain permanently open. Therefore, wound irrigation, careful hemostasis and closure, with insertion of a new flap on the left side. Suturing of the cannula. Flap check again after skin closure. Now good blood circulation. Insertion of a 7 mm tracheostomy tube. The forearm was closed with a split-thickness skin graft taken from the right thigh. A 0.7 mm thick split-thickness skin graft was first removed from the right thigh. Hydrogel or hydrocholoid dressing is then applied here. The arm is then primarily closed in the proximal area and the split skin is successively incorporated into the defect in the area of the forearm. Care is taken to protect the lateral antebrachial cutaneous nerve of the median nerve and also to protect the ulnar artery. Octenidine-Mepilex dressing is then applied. Loose compresses are placed over this and fixed in place with absorbent cotton. Application or adjustment of a Cramer splint and fixation with a bandage. Positioning of the arm. Arm always well perfused with 100% saturation until the end of the procedure. Patient goes to the intensive care unit for postoperative monitoring. Heparin perfusor 500 units/hour must be continued postoperatively. Additionally aspirin 50 mg i.v., please repeat this the next day. Flap check every ˝ hour for the first 1 to 2 days, then according to the schedule for a total of 5 days. Antibiotics given intraoperatively should be continued for 1 week with Unacid. Nutrition via the inserted PEG tube. On the 12th day, approx. gruel swallow and then, depending on the gruel swallow or swallowing function, diet build-up or initiation of swallowing rehabilitation. Overall, in the case of radiochemotherapy for rhabdomyosarcoma, difficult situation with regard to the arterial anastomosis. Overall tongue base tumor cT2 to 3, defect coverage by radial flap. Please present at the interdisciplinary tumor conference after receiving the final histology. \ No newline at end of file diff --git a/195/InvasionFront_CD3_block6_x5_y11_patient195_0.json b/195/InvasionFront_CD3_block6_x5_y11_patient195_0.json new file mode 100644 index 0000000000000000000000000000000000000000..57bc9920f96d74fbf2364075be589e86810dfa29 --- /dev/null +++ b/195/InvasionFront_CD3_block6_x5_y11_patient195_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 29059.6, + "Num Detections": 23342, + "Num Negative": 19474, + "Num Positive": 3868, + "Positive %": 16.57, + "Num Positive per mm^2": 1546.1 + } +} \ No newline at end of file diff --git a/195/InvasionFront_CD3_block6_x6_y11_patient195_1.json b/195/InvasionFront_CD3_block6_x6_y11_patient195_1.json new file mode 100644 index 0000000000000000000000000000000000000000..252fb36aca0f654e85691a480b8d1a75c01d0a7f --- /dev/null +++ b/195/InvasionFront_CD3_block6_x6_y11_patient195_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 29184.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/195/InvasionFront_CD8_block6_x5_y9_patient195_0.json b/195/InvasionFront_CD8_block6_x5_y9_patient195_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4fc2a2f868b9ba65ee1ff5548bd7ab8b84270233 --- /dev/null +++ b/195/InvasionFront_CD8_block6_x5_y9_patient195_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16866.1, + "Centroid Y µm": 23037.8, + "Num Detections": 22597, + "Num Negative": 21634, + "Num Positive": 963, + "Positive %": 4.262, + "Num Positive per mm^2": 372.03 + } +} \ No newline at end of file diff --git a/195/InvasionFront_CD8_block6_x6_y9_patient195_1.json b/195/InvasionFront_CD8_block6_x6_y9_patient195_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f1e0b809066896991ac909662f80de16161e3b67 --- /dev/null +++ b/195/InvasionFront_CD8_block6_x6_y9_patient195_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19464.7, + "Centroid Y µm": 23337.6, + "Num Detections": 19435, + "Num Negative": 19376, + "Num Positive": 59, + "Positive %": 0.3036, + "Num Positive per mm^2": 29.16 + } +} \ No newline at end of file diff --git a/195/TumorCenter_CD3_block6_x5_y9_patient195_0.json b/195/TumorCenter_CD3_block6_x5_y9_patient195_0.json new file mode 100644 index 0000000000000000000000000000000000000000..880a79b86752ed59681cb258e2fe91670353a992 --- /dev/null +++ b/195/TumorCenter_CD3_block6_x5_y9_patient195_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 22912.9, + "Num Detections": 12032, + "Num Negative": 9837, + "Num Positive": 2195, + "Positive %": 18.24, + "Num Positive per mm^2": 1563.7 + } +} \ No newline at end of file diff --git a/195/TumorCenter_CD3_block6_x6_y9_patient195_1.json b/195/TumorCenter_CD3_block6_x6_y9_patient195_1.json new file mode 100644 index 0000000000000000000000000000000000000000..036b970a943c6a27917060853d7835f87ce59546 --- /dev/null +++ b/195/TumorCenter_CD3_block6_x6_y9_patient195_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 22688.0, + "Num Detections": 24449, + "Num Negative": 21516, + "Num Positive": 2933, + "Positive %": 12.0, + "Num Positive per mm^2": 1105.4 + } +} \ No newline at end of file diff --git a/195/TumorCenter_CD8_block6_x5_y9_patient195_0.json b/195/TumorCenter_CD8_block6_x5_y9_patient195_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8c12fb6df1823c71496bf61292f9f34337bd742e --- /dev/null +++ b/195/TumorCenter_CD8_block6_x5_y9_patient195_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 23262.7, + "Num Detections": 14100, + "Num Negative": 12324, + "Num Positive": 1776, + "Positive %": 12.6, + "Num Positive per mm^2": 1134.2 + } +} \ No newline at end of file diff --git a/195/TumorCenter_CD8_block6_x6_y9_patient195_1.json b/195/TumorCenter_CD8_block6_x6_y9_patient195_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9c1674e692bff0daf5e58daca6be025b90e3a883 --- /dev/null +++ b/195/TumorCenter_CD8_block6_x6_y9_patient195_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 23162.7, + "Num Detections": 26751, + "Num Negative": 24630, + "Num Positive": 2121, + "Positive %": 7.929, + "Num Positive per mm^2": 784.08 + } +} \ No newline at end of file diff --git a/195/history_text.txt b/195/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/195/icd_codes.txt b/195/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..48d1e2b7878d6a25e47cb893afa9c7074cda401b --- /dev/null +++ b/195/icd_codes.txt @@ -0,0 +1 @@ +Karzinom der Plica aryepiglottica[C13.1 L] \ No newline at end of file diff --git a/195/ops_codes.txt b/195/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..584bf82323b064f4fa5a3c33bae620eea0fea865 --- /dev/null +++ b/195/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 6 Regionen[5-403.32 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme freier Radialis-Lappen[5-858.23 L] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Transplantat[5-295.14 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] \ No newline at end of file diff --git a/195/patient_clinical_data.json b/195/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..46512e6e8a7bfe0de9a54a3ee1c48cda421fe829 --- /dev/null +++ b/195/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 48, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 63, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/195/patient_pathological_data.json b/195/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cdb6db9efae55b2194bf1fd8fd7ff9b719d97a22 --- /dev/null +++ b/195/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "195", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 6.0, + "number_of_resected_lymph_nodes": 17, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/195/surgery_description.txt b/195/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0beecd3559aed63e091738be914bc37f18f8986f --- /dev/null +++ b/195/surgery_description.txt @@ -0,0 +1 @@ +TU resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheostomy, PEG placement diff --git a/195/surgery_report.txt b/195/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b40d8fb01fcf387145023137955d80962756024b --- /dev/null +++ b/195/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first perform a diagnostic hypopharyngoscopy. There is no macroscopic evidence of a tumor, so several tissue samples are taken. From these, the PE from the piriform sinus is found to be infiltrated by tumor. Start of surgery after appropriate preparation. After sharp transection of the cutis, the subcutaneous cutis and the platysma as well as the subcutaneous fatty tissue and the platysma, the large metastasis is exposed. Exposure of the vascular nerve sheath caudally and ligation of the internal jugular vein. Dissection of the sternocleidomstoideus muscle caudally. Expose the digastric muscle starting at the posterior abdomen. From there, follow ventrally to the omohyodeus muscle. Locate and ligate the internal jugular vein cranially under the digastric muscle. Then dissect the common carotid artery starting from caudal to cranial. Contrary to the radiological report, the carotid artery is not infiltrated. Therefore, the bifurcation together with the internal and external carotid artery can be dissected away from the metastasis in a healthy layer. Exposure and preservation of the hypoglossal nerve on the left side until the end. The sternocleidomastoid muscle is then removed together with the cranial accessorius nerve. The metastasis is then mobilized laterally, including resection of the cervical plexus and parts of the underlying musculature. The phrenic nerve is exposed and spared until the end. However, the vagus nerve runs through the metastasis and is separated from it caudally and cranially. The large metastasis is then resected with the surrounding fatty tissue in the form of a radical neck dissection. Metastases extend caudally to the clavicle. It is assumed that the thoracic duct is also injured here. The surrounding connective tissue is therefore grasped and ligated. In addition, the caudal stump of the sternocleidomastoid muscle is further exposed and sutured onto the suspected defect site. The upper horn of the thyroid cartilage and the lateral part of the hyoid bone are then exposed. Complete mobilization of the hypoglossal nerve, which is turned upwards. Separation of the digastric muscle. Exposing the hypopharyngeal side wall and performing the lateral pharyngotomy. Enter the pharynx at approximately the level of the upper edge of the epiglottis. From there, the tumor is explored in the direction of the piriform sinus. This is about the size of a pea and is hard to the touch. Triggering of the piriform sinus so that the tumor can be successively excised under vision. The resection covers the entire piriform sinus on the left side and extends to the arytenoid cartilage on the left side. The specimen is then mounted on a cork plate with corresponding markings. The frozen section histology shows that there is still some CIS in the area of the medial margin, i.e. towards the posterior wall of the hypopharynx. Therefore, a resection is performed at this site and another frozen section is made at the margin, which then proves to be free of tumor and CIS. The defect measures approximately 5 1/2 x 5 cm, so that the corresponding radial lobe of is elevated. Elevation of the radial forearm flap on the left (/PJ): Palpatory identification of the distal radial artery. Marking of the flap borders (6 x 4 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of graft elevation without complications. PEG placement (/): Entering with the gastroesophagoscope under air insufflation, pre-scanning into the stomach. After spontaneous diaphanoscopy, insertion of a PEG in the typical manner using the thread pull-through method. Neck dissection is then performed on the right side. All non-lymphatic structures in regions II to V are removed while sparing them. The facial artery is then traced up to the lower jaw and deposited there so that it can be used for subsequent anastomosis. A breakthrough is then created via the supralaryngeal muscles to the opposite side for insertion of the flap pedicle. After lifting the radial flap, it is sutured into the hypopharyngeal defect. The pedicle is then passed over the entire transition to the opposite side and arterially connected to the facial artery there. The venous anastomosis is made with 2 veins to the internal jugular vein. The lifting defect is then treated with split skin from the right thigh of . Subsequently reintubation onto an 8 . cannula. Complete wound closure after insertion of Redon drains and 2 drainage flaps in the neck. End of the operation, transfer of the patient to anesthesia. Conclusion: Resection of a small piriform sinus carcinoma on the left side via lateral pharyngectomy with a large metastasis on the left side. Contrary to the radiological findings, the common carotid artery was not infiltrated by the tumor. Radical neck dissection on the left side and selective neck dissection on the right side. Defect coverage with radial lobe graft from the left forearm. Due to the extensive metastasis, adjuvant radiochemotherapy is recommended. \ No newline at end of file diff --git a/196/InvasionFront_CD3_block14_x3_y7_patient196_0.json b/196/InvasionFront_CD3_block14_x3_y7_patient196_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c47a823180f17edd36bd96d852750aee541db362 --- /dev/null +++ b/196/InvasionFront_CD3_block14_x3_y7_patient196_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11768.8, + "Centroid Y µm": 21413.7, + "Num Detections": 15677, + "Num Negative": 15433, + "Num Positive": 244, + "Positive %": 1.556, + "Num Positive per mm^2": 137.69 + } +} \ No newline at end of file diff --git a/196/InvasionFront_CD3_block14_x4_y7_patient196_1.json b/196/InvasionFront_CD3_block14_x4_y7_patient196_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0313465298c3503f9d29b74e2745670c67f16e00 --- /dev/null +++ b/196/InvasionFront_CD3_block14_x4_y7_patient196_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14417.4, + "Centroid Y µm": 21438.6, + "Num Detections": 19692, + "Num Negative": 18792, + "Num Positive": 900, + "Positive %": 4.57, + "Num Positive per mm^2": 399.42 + } +} \ No newline at end of file diff --git a/196/InvasionFront_CD8_block14_x3_y7_patient196_0.json b/196/InvasionFront_CD8_block14_x3_y7_patient196_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba855731e2b107c62a3405f6b5f0ec1fbb5fb5e5 --- /dev/null +++ b/196/InvasionFront_CD8_block14_x3_y7_patient196_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11918.7, + "Centroid Y µm": 17115.9, + "Num Detections": 16978, + "Num Negative": 16824, + "Num Positive": 154, + "Positive %": 0.9071, + "Num Positive per mm^2": 84.48 + } +} \ No newline at end of file diff --git a/196/InvasionFront_CD8_block14_x4_y7_patient196_1.json b/196/InvasionFront_CD8_block14_x4_y7_patient196_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0b9515731e66eafcfbefce6dfd7f9192cf774cbb --- /dev/null +++ b/196/InvasionFront_CD8_block14_x4_y7_patient196_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14417.4, + "Centroid Y µm": 17140.9, + "Num Detections": 20396, + "Num Negative": 19749, + "Num Positive": 647, + "Positive %": 3.172, + "Num Positive per mm^2": 280.35 + } +} \ No newline at end of file diff --git a/196/TumorCenter_CD3_block14_x3_y7_patient196_0.json b/196/TumorCenter_CD3_block14_x3_y7_patient196_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14180b6f3af4830269e18f74aedf6457fcaceede --- /dev/null +++ b/196/TumorCenter_CD3_block14_x3_y7_patient196_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11468.9, + "Centroid Y µm": 17765.6, + "Num Detections": 16693, + "Num Negative": 15581, + "Num Positive": 1112, + "Positive %": 6.661, + "Num Positive per mm^2": 522.03 + } +} \ No newline at end of file diff --git a/196/TumorCenter_CD3_block14_x4_y7_patient196_1.json b/196/TumorCenter_CD3_block14_x4_y7_patient196_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2934af0fb2bf09e7417b20f63c32aede07ab034b --- /dev/null +++ b/196/TumorCenter_CD3_block14_x4_y7_patient196_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 17915.5, + "Num Detections": 15739, + "Num Negative": 15131, + "Num Positive": 608, + "Positive %": 3.863, + "Num Positive per mm^2": 257.71 + } +} \ No newline at end of file diff --git a/196/TumorCenter_CD8_block14_x3_y7_patient196_0.json b/196/TumorCenter_CD8_block14_x3_y7_patient196_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a5ef065c241bcc6914d8b635353411fa2b6d64b2 --- /dev/null +++ b/196/TumorCenter_CD8_block14_x3_y7_patient196_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 17990.5, + "Num Detections": 18275, + "Num Negative": 17007, + "Num Positive": 1268, + "Positive %": 6.938, + "Num Positive per mm^2": 604.27 + } +} \ No newline at end of file diff --git a/196/TumorCenter_CD8_block14_x4_y7_patient196_1.json b/196/TumorCenter_CD8_block14_x4_y7_patient196_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ba3ee78c40c915debc03945018550eb02ac15ae3 --- /dev/null +++ b/196/TumorCenter_CD8_block14_x4_y7_patient196_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 17990.5, + "Num Detections": 17836, + "Num Negative": 17271, + "Num Positive": 565, + "Positive %": 3.168, + "Num Positive per mm^2": 242.74 + } +} \ No newline at end of file diff --git a/196/history_text.txt b/196/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/196/icd_codes.txt b/196/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/196/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/196/ops_codes.txt b/196/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ac3de0c0800edbcce92e7588eb17f0c3eff3a95c --- /dev/null +++ b/196/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Mikrolaryngoskopie[1-610.2 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Endoskopische Laserresektion am Larynx[5-302.5 ] \ No newline at end of file diff --git a/196/patient_clinical_data.json b/196/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..72ad6fdea87a9ff811e3b5622bc45fc3df2373d0 --- /dev/null +++ b/196/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/196/patient_pathological_data.json b/196/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3d84b90ec3f85b75d9660b95a3187c13b33b8878 --- /dev/null +++ b/196/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "196", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/196/surgery_description.txt b/196/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b45ea1174e5848dbc7e53358c76517376cec36f6 --- /dev/null +++ b/196/surgery_description.txt @@ -0,0 +1 @@ +Laser resection diff --git a/196/surgery_report.txt b/196/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..08e1756a2608bec6e4b7b9164bbd80ddb53836a5 --- /dev/null +++ b/196/surgery_report.txt @@ -0,0 +1 @@ +Initially induction of anesthesia and transoral and tracheal intubation using a laser tube by the anesthesia colleagues and positioning of the patient by the surgeon. Adjustment of the endolaryngeal findings. This revealed a pronounced exophytic mass starting from the area of the vocal process of the left arytenoid cartilage, growing anteriorly into the anterior commissure, growing laterally into the pocket fold, thus T2 glottic laryngeal carcinoma. With good adjustability, decision to attempt transoral laser resection. Setting the laser beam to continuous mode 6 watts. The laser moves around the mass. It is then possible to remove the mass macroscopically in toto using the piecemeal technique. Three marginal samples are then taken (supraglottis, anterior commissure, vocal process). All three marginal samples were found to be tumor-free by the pathology colleague . An R0 resection can therefore be assumed. Repeated inspection. Hemostasis using monopolar coagulation and swabs soaked in suprarenin. Dry conditions. Removal of the Kleinsasser tube. Completion of the procedure without complications. Transoral laser resection of an R0 resection of a cT2 glottic laryngeal carcinoma on the left. Please schedule follow-up MLE in 8 weeks. \ No newline at end of file diff --git a/197/InvasionFront_CD3_block12_x1_y2_patient197_0.json b/197/InvasionFront_CD3_block12_x1_y2_patient197_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14630aa63f16fd738a63a63b2477837536c389f9 --- /dev/null +++ b/197/InvasionFront_CD3_block12_x1_y2_patient197_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4772.5, + "Centroid Y µm": 9445.0, + "Num Detections": 19177, + "Num Negative": 18961, + "Num Positive": 216, + "Positive %": 1.126, + "Num Positive per mm^2": 126.55 + } +} \ No newline at end of file diff --git a/197/InvasionFront_CD3_block12_x2_y2_patient197_1.json b/197/InvasionFront_CD3_block12_x2_y2_patient197_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e2fa9692cf545f940f635387c8c4b28b10f60fa4 --- /dev/null +++ b/197/InvasionFront_CD3_block12_x2_y2_patient197_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7272.7, + "Centroid Y µm": 9857.6, + "Num Detections": 14069, + "Num Negative": 13440, + "Num Positive": 629, + "Positive %": 4.471, + "Num Positive per mm^2": 452.57 + } +} \ No newline at end of file diff --git a/197/InvasionFront_CD8_block12_x1_y2_patient197_0.json b/197/InvasionFront_CD8_block12_x1_y2_patient197_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5de41566d0497c1ebda86d260a554cc5a406a205 --- /dev/null +++ b/197/InvasionFront_CD8_block12_x1_y2_patient197_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4047.9, + "Centroid Y µm": 9245.1, + "Num Detections": 17113, + "Num Negative": 16920, + "Num Positive": 193, + "Positive %": 1.128, + "Num Positive per mm^2": 114.65 + } +} \ No newline at end of file diff --git a/197/InvasionFront_CD8_block12_x2_y2_patient197_1.json b/197/InvasionFront_CD8_block12_x2_y2_patient197_1.json new file mode 100644 index 0000000000000000000000000000000000000000..23b259296da673f2f9da647f3002839aff2cc57f --- /dev/null +++ b/197/InvasionFront_CD8_block12_x2_y2_patient197_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6611.4, + "Centroid Y µm": 9255.9, + "Num Detections": 11737, + "Num Negative": 11332, + "Num Positive": 405, + "Positive %": 3.451, + "Num Positive per mm^2": 320.09 + } +} \ No newline at end of file diff --git a/197/TumorCenter_CD3_block12_x1_y2_patient197_0.json b/197/TumorCenter_CD3_block12_x1_y2_patient197_0.json new file mode 100644 index 0000000000000000000000000000000000000000..011cdbd3ee05629af6724d7de1e83096f5adcb0d --- /dev/null +++ b/197/TumorCenter_CD3_block12_x1_y2_patient197_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3848.0, + "Centroid Y µm": 5547.1, + "Num Detections": 14010, + "Num Negative": 13810, + "Num Positive": 200, + "Positive %": 1.428, + "Num Positive per mm^2": 128.15 + } +} \ No newline at end of file diff --git a/197/TumorCenter_CD3_block12_x2_y2_patient197_1.json b/197/TumorCenter_CD3_block12_x2_y2_patient197_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f85cea84d4caffdb5b20f00a79bb6c730832c017 --- /dev/null +++ b/197/TumorCenter_CD3_block12_x2_y2_patient197_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 5272.2, + "Num Detections": 16995, + "Num Negative": 16475, + "Num Positive": 520, + "Positive %": 3.06, + "Num Positive per mm^2": 287.93 + } +} \ No newline at end of file diff --git a/197/TumorCenter_CD8_block12_x1_y2_patient197_0.json b/197/TumorCenter_CD8_block12_x1_y2_patient197_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8d9316aae77b1bb38df7fe362c219001144662b1 --- /dev/null +++ b/197/TumorCenter_CD8_block12_x1_y2_patient197_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7321.1, + "Centroid Y µm": 14292.4, + "Num Detections": 9611, + "Num Negative": 9527, + "Num Positive": 84, + "Positive %": 0.874, + "Num Positive per mm^2": 59.87 + } +} \ No newline at end of file diff --git a/197/TumorCenter_CD8_block12_x2_y2_patient197_1.json b/197/TumorCenter_CD8_block12_x2_y2_patient197_1.json new file mode 100644 index 0000000000000000000000000000000000000000..107b845bd6de9bc5a65bc53c0ff0ab7b696a920d --- /dev/null +++ b/197/TumorCenter_CD8_block12_x2_y2_patient197_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9919.7, + "Centroid Y µm": 14342.4, + "Num Detections": 16140, + "Num Negative": 16044, + "Num Positive": 96, + "Positive %": 0.5948, + "Num Positive per mm^2": 52.04 + } +} \ No newline at end of file diff --git a/197/history_text.txt b/197/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f0763af469b50e2b9efdc1c0897aa59d60136dca --- /dev/null +++ b/197/history_text.txt @@ -0,0 +1 @@ +The patient was diagnosed with an extensive, suspicious mass with cT4a cN2c oropharyngeal carcinoma as part of a panendoscopy. No malignancy could be detected in the sample taken. Due to the clinically and radiologically clearly malignant tumor formation, indication for resection with partial pharyngectomy and laryngectomy. Sonographic cN2c neck status without infiltration of neck structures, \ No newline at end of file diff --git a/197/icd_codes.txt b/197/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/197/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/197/ops_codes.txt b/197/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d326cc865421ac3a1a80d74914647ccfa21d95f8 --- /dev/null +++ b/197/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Biopsie ohne Inzision am Pharynx: Oropharynx: Sonstige[1-422.0x L] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/197/patient_clinical_data.json b/197/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..74eefbf68198acfc6d951020d30859c9e9711058 --- /dev/null +++ b/197/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/197/patient_pathological_data.json b/197/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e10eb94bc70fb7a8cd2f00d1efc5a1661cca71e7 --- /dev/null +++ b/197/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "197", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 50, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "Neuroendocrine_Carcinoma", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/197/surgery_description.txt b/197/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1a1e26edeba2182ebaf140dfe26b553ff829ef62 --- /dev/null +++ b/197/surgery_description.txt @@ -0,0 +1 @@ +Partial pharyngectomy with laryngectomy, Modified radical bilateral neck dissection, Endoscopy, Panendoscopy diff --git a/197/surgery_report.txt b/197/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3e6850420fcda201f2a7f628070e9e2393cca272 --- /dev/null +++ b/197/surgery_report.txt @@ -0,0 +1 @@ +Initially bronchoscopic intubation by the anesthesia colleagues. This is initially much more difficult in the case of massive tumor formation in the epiglottis area. The patient is then positioned by the surgeon. Entry with the small bore tube and inspection of the inconspicuous oral cavity. Inconspicuous tonsils and posterior pharyngeal wall. The base of the tongue itself is also inconspicuous, but there is a submucosal tumor formation directly in the vallecula, and the epiglottis is massively distended and depleted. As described above, the tumor extends on the right side over the aryepiglottic fold up to the arya. The aryepiglottic fold is reached on the left side. The tumor formation breaks through the epiglottis towards the supraglottis. As far as can be assessed, the glottic plane itself is free. Certainly no growth towards the subglottic. Several sufficient samples are now taken in the sense of a circumscribed tumor debulking. These are sent for frozen section diagnostics. This shows a poorly differentiated carcinoma, which, however, most likely corresponds to an adeno- or adenoid cystic carcinoma. After discussing the case with , either a primary adenoid cystic carcinoma or a metastasis can be considered. Therefore, case discussion with and . Another review of the CT/thorax. Here, as described above, no suspicious changes. Due to the extensive, massive clinical findings, confirmation of the indication for tumor resection with laryngectomy in the case of both differential diagnoses. Then repositioning. Injection of xylocaine with added adrenaline. Skin incision in the sense of a modified Gluck Sorensen. Cut through skin and subcutaneous tissue. Separation of the platysma. Creation of a platysma flap on both sides. Antero-completion of the platysmal flap. Creation of the apron flap. Suture of the apron flap upwards. An external jugular vein is only present and preserved on the right side, as is the auricular nerve on both sides. Exposure of the sternocleidomastoid muscle and the omohyoid muscle. Initially starting with the left side: free dissection of the sternocleidomastoid muscle already reveals a clinically clear lymph node metastasis in level III, contact of the muscle, but with clear connective tissue separation, so that the muscle is preserved here. Visualization of the omohyoid muscle, visualization of the submandibular gland. This is somewhat coarsely altered, but without any suspicious changes. Visualization of the digastric muscle. Release of the anterior neck preparation while carefully protecting the superior thyroid artery. Due to the location of the metastasis, the facial vein must be ligated and removed. Now free dissection of the internal jugular vein. Throughout the course of both neck dissections, there are clearly vulnerable vessels. Vessels have to be ligated several times. Dissection of the internal jugular vein. Repeated hemostasis, but overall continuity-preserving exposure, exposure and exposure of the common carotid artery, exposure of the bulb, exposure and preservation of the hypoglossal nerve. Several, not necessarily suspicious lymph nodes in the area of the jugulo-facial angle. Exposure of the accessorius nerve. Release of the accessorius triangle. Finally, release of level V with visualization and preservation of the vagus nerve and caudal phrenic nerve. Exposure and selective coagulation of the thoracic duct. Finally, absolutely dry conditions here. Final wound inspection and with dry and cleared conditions, detachment of the infrahyoid musculature on the left side. Skeletonize the left side of the larynx. Exposure of the hyoid. Exposure of the posterior horn of the thyroid gland and selective ligation of the laryngeal bundle. Now turn to the opposite side. In principle the same procedure here. Exposure of the sternocleidomastoid muscle. Here, too, a metastasis-specific mass in level III, located on the internal jugular vein, can be seen at exactly the same location as on the opposite side. The muscle can be separated from this. Cranially in level II a clinically clear lymph node metastasis measuring approx. 3 cm. The muscle can also be preserved with a clear connective tissue separating layer. Visualization of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Here too, the facial vein must be ligated and ligated after injury and in the presence of metastases. All in all, difficult dissection conditions with extremely vulnerable vessels and multiple vascular injuries. Free dissection of the internal jugular vein and double vascular suture. However, here too, exposure preserving continuity overall. Exposure and preservation of the accessorius nerve. This can also be easily detached from the metastasis. Release of the accessorius triangle and release of level V, also exposing the vagus nerve and the phrenic nerve and preserving the structures, also preserving the cervical plexus. Anteriorly, the superior thyroid artery and the hypoglossal nerve were preserved. Now, after wound inspection and interim demonstration of findings on , detachment of the infrahyoid musculature on the right side and skeletonization of the larynx. Exposure of the cricoid cartilage and the anterior surface of the trachea. Overall relatively high larynx. Exposure of the first 3 to 4 tracheal clasps. Exposure of the thyroid cartilage horn. Selective coagulation of the laryngeal bundle. Exposure of the hyoid. Now detachment of the perichondrium from the thyroid cartilage on the right side. Now, after dislocation of the hyoid, entry laterally on the right above the hyoid. The entrance here is in the area of the pharyngeal side wall, slightly above the vallecula and at a safe distance of approx. 1 cm from the tumor. As described above, the tumor is located submucosally in the vallecula, consuming and breaking through the epiglottis. A strip of the base of the tongue is resected to obtain a safety margin, but there is clearly no macroscopic or palpatory infiltration. Resection of the tumor with a good 1 cm safety margin and soft tissue on all sides in the depth. The hypopharyngeal side wall, especially the piriform sinus, is free on all sides. Resection along the aryepiglottic fold and narrow postcricoidal separation here. This region is far from being reached by the tumor. Now release the laryngeal skeleton while carefully preserving the pharyngeal tube and maintaining a strong muscle mantle. Careful protection of the oesophagus and then tracheotomy. Resection of 2 tracheal clips with relatively high trachea. Angled removal of the trachea and thus the tumor. Snaring and incision of the trachea anteriorly. Now inspection of the tumor and consultation of . It can now be seen that the tumor, as already described above, moves through the epiglottis towards the supraglottis, moves on the right side towards the arya, infiltrates the pocket fold here, the glottic plane itself is free, as is the subglottis. Now confirmation of the macroscopic in sano resection on the specimen. The tumor is also surrounded on all sides by a soft tissue mantle in depth. The specimen is now thread-marked for frozen section diagnostics and is classified as R0. Therefore, if the pharyngeal mucosa is sufficient and the pharyngeal tube is strong, primary wound closure or reconstruction with local mucosa is performed. Careful submucosal pharyngeal suture with 3.0 SH plus. Countersinking of the corners in the area of the base of the tongue and the caudal pharyngeal suture. Then muscle suture and stitching over the thyroid gland and infrahyoid muscles. Finally, stable pharynx sutured in several layers. Strong adaptation also in the area of the base of the tongue. Final wound inspection of all circumscribed wound cavities. Final hemostasis. Irrigation of the wound with Ringer's solution and, in dry conditions, insertion of a 10-piece Redon drain. Completion of the incision of the tracheostoma with mucocutaneous anastomosis and finally careful, two-layer wound closure and reintubation with a 10-gauge tracheoflex cannula and completion of the procedure at this point without any indication of complications. Conclusion: Intraoperative R0 resected cT4a cN2c oropharyngeal carcinoma. Depending on the definitive histology, adjuvant therapy is indicated. If histology indicates a metastasis, extended staging may be necessary. If the wound is normal, please swallow gruel on the 8th to 9th postoperative day. \ No newline at end of file diff --git a/198/InvasionFront_CD3_block21_x5_y7_patient198_0.json b/198/InvasionFront_CD3_block21_x5_y7_patient198_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba6bb438940dab0674c65509f688642a4f41f912 --- /dev/null +++ b/198/InvasionFront_CD3_block21_x5_y7_patient198_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 28385.0, + "Num Detections": 18537, + "Num Negative": 13798, + "Num Positive": 4739, + "Positive %": 25.57, + "Num Positive per mm^2": 2520.9 + } +} \ No newline at end of file diff --git a/198/InvasionFront_CD3_block21_x6_y7_patient198_1.json b/198/InvasionFront_CD3_block21_x6_y7_patient198_1.json new file mode 100644 index 0000000000000000000000000000000000000000..43b20003c29a6975253a7457fde8adb3a0d97293 --- /dev/null +++ b/198/InvasionFront_CD3_block21_x6_y7_patient198_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21338.7, + "Centroid Y µm": 28659.8, + "Num Detections": 15156, + "Num Negative": 12041, + "Num Positive": 3115, + "Positive %": 20.55, + "Num Positive per mm^2": 1976.0 + } +} \ No newline at end of file diff --git a/198/InvasionFront_CD8_block21_x5_y7_patient198_0.json b/198/InvasionFront_CD8_block21_x5_y7_patient198_0.json new file mode 100644 index 0000000000000000000000000000000000000000..657c21ba609c491d2af1ef004692b7e7ce217ec7 --- /dev/null +++ b/198/InvasionFront_CD8_block21_x5_y7_patient198_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 17240.9, + "Num Detections": 23526, + "Num Negative": 21331, + "Num Positive": 2195, + "Positive %": 9.33, + "Num Positive per mm^2": 1009.6 + } +} \ No newline at end of file diff --git a/198/InvasionFront_CD8_block21_x6_y7_patient198_1.json b/198/InvasionFront_CD8_block21_x6_y7_patient198_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4e0498e3ac5dff47c7e47a43c0848b32ec20e026 --- /dev/null +++ b/198/InvasionFront_CD8_block21_x6_y7_patient198_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 17165.9, + "Num Detections": 23648, + "Num Negative": 21613, + "Num Positive": 2035, + "Positive %": 8.605, + "Num Positive per mm^2": 917.54 + } +} \ No newline at end of file diff --git a/198/TumorCenter_CD3_block21_x5_y7_patient198_0.json b/198/TumorCenter_CD3_block21_x5_y7_patient198_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e6a048f6f7e8aca53898a2a2d571716c6a55b985 --- /dev/null +++ b/198/TumorCenter_CD3_block21_x5_y7_patient198_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 20064.4, + "Num Detections": 25422, + "Num Negative": 17615, + "Num Positive": 7807, + "Positive %": 30.71, + "Num Positive per mm^2": 3018.1 + } +} \ No newline at end of file diff --git a/198/TumorCenter_CD3_block21_x6_y7_patient198_1.json b/198/TumorCenter_CD3_block21_x6_y7_patient198_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6997b8c14097b0267f53bfaaa0390376735d6ad4 --- /dev/null +++ b/198/TumorCenter_CD3_block21_x6_y7_patient198_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 20114.3, + "Num Detections": 26602, + "Num Negative": 17368, + "Num Positive": 9234, + "Positive %": 34.71, + "Num Positive per mm^2": 3324.7 + } +} \ No newline at end of file diff --git a/198/TumorCenter_CD8_block21_x5_y7_patient198_0.json b/198/TumorCenter_CD8_block21_x5_y7_patient198_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fb77c6101f1da8cb7ca50b6edd3d4cba7f460eb9 --- /dev/null +++ b/198/TumorCenter_CD8_block21_x5_y7_patient198_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 32507.8, + "Num Detections": 26560, + "Num Negative": 20103, + "Num Positive": 6457, + "Positive %": 24.31, + "Num Positive per mm^2": 2468.2 + } +} \ No newline at end of file diff --git a/198/TumorCenter_CD8_block21_x6_y7_patient198_1.json b/198/TumorCenter_CD8_block21_x6_y7_patient198_1.json new file mode 100644 index 0000000000000000000000000000000000000000..189bf44ccf3bf1023ca10b272ca18656415e3ed2 --- /dev/null +++ b/198/TumorCenter_CD8_block21_x6_y7_patient198_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20888.9, + "Centroid Y µm": 32682.7, + "Num Detections": 29779, + "Num Negative": 24133, + "Num Positive": 5646, + "Positive %": 18.96, + "Num Positive per mm^2": 2029.0 + } +} \ No newline at end of file diff --git a/198/history_text.txt b/198/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1643f7d6b59e33700f2bbffaf516168a7646d471 --- /dev/null +++ b/198/history_text.txt @@ -0,0 +1 @@ +A right cervical lymph node had been removed in the patient's history, which turned out to be a squamous cell carcinoma. PET-CT showed a suspicious FDG accumulation in the area of the right tonsil, which is why a tonsillectomy was indicated before CUP panendoscopy and completion of the neck dissection. \ No newline at end of file diff --git a/198/icd_codes.txt b/198/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/198/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/198/ops_codes.txt b/198/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa34f06e4ecdf48650e1e2dc4dc9333b0cea782a --- /dev/null +++ b/198/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie (ohne Adenotomie): Radikal, transoral[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 R] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] \ No newline at end of file diff --git a/198/patient_clinical_data.json b/198/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6b17e10c9784982f4edd00a3b3e94577503b871c --- /dev/null +++ b/198/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 53, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 7, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/198/patient_pathological_data.json b/198/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ab622769054f35af7b389e4716a4377b4443e9de --- /dev/null +++ b/198/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "198", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/198/surgery_description.txt b/198/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ef54e254000ecda0950cc56323c2ff8de24a67ea --- /dev/null +++ b/198/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy on the right and Neck dissection diff --git a/198/surgery_report.txt b/198/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..54fdc7e7ccba0246e1ed61ced4d40b7083751c36 --- /dev/null +++ b/198/surgery_report.txt @@ -0,0 +1 @@ +After an initial consultation with the anesthesia colleagues, rigid tracheobronchoscopy is performed after laryngoscopic adjustment of the glottic plane. The glottis, subglottis, trachea and main bronchi were found to be normal and inconspicuous, whereupon the patient was intubated by the surgeon without any problems. The patient is then repositioned for flexible esophagoscopy and gastroscopy: here too, the flexible instrument is inserted into the esophagus without any problems and the patient is visualized under vision as far as the stomach, where a regular folded relief can be seen. On retraction, after aspiration of the air, the esophagus is carefully reflected again, where the mucosal conditions are also normal and inconspicuous. After repositioning the patient again, the hypopharynx and larynx are inspected, where the mucous membrane conditions are also normal and unremarkable in all areas. The base of the tongue is also completely free of irritation and unremarkable on palpation. After repositioning the patient, the mouth retractor is inserted and the oral cavity and oropharynx are inspected. This reveals a clearly enlarged tonsil on the right side, which appears completely non-irritant and inconspicuous on the surface. The mucosal incision is then made close to the uvula and the anterior and posterior palatal arches are sharply dissected. Release of the tonsil at the upper tonsil pole, after exposure, coagulation and separation of the upper pole vessels. The tonsil can then be bluntly dissected from the tonsillar lobe without difficulty. The preparation is carried out with careful hemostasis up to the lower tonsil pole. At the transition to the base of the tongue, the lower pole vessels are carefully coagulated again. Once these have been severed and separated, the tonsil is removed together with a small part of the base of the tongue, the tongue base tonsil. After the intraoperative frozen section diagnosis shows that the tonsil is completely infiltrated by the tumor, the advice is given to resect all areas. This is done in the area of the anterior and posterior palatal arch as well as in the entire area of the tonsil lobe, so that there is a safety margin of about 1 cm from the tonsil bed in all areas. All resections and marginal samples are then found to be tumor-free intraoperatively, so that an R0 resection can be assumed in the primary specimen. Careful hemostasis is then performed again and a nasogastric feeding tube is inserted. Since parapharyngeal fat is exposed here, the patient should be fed via this for a few days. The patient was then repositioned to complete the neck dissection on the right side. Injection of local anesthetic with adrenaline and then skin incision along the front edge of the sternocleidomastoid muscle. Then dissection in depth to the cervical vascular sheath. This is clearly scarred in the area of the vein angle from the primary lymph node removal. The most careful and laborious dissection is required here. In the end, the entire lateral neck preparation can be lifted laterally from the jugular vein. In the course of long dissection. Exposure, neurolysis, displacement and re-embedding of the vagus nerve. Dissection, exposure, neurolysis, displacement and re-embedding of the accessorius nerve. After clearing the accessorius triangle, the entire lateral neck preparation is then dissected and removed from cranial to caudal while sparing the branches of the cervical plexus. The anterior neck preparation is then removed while sparing the branches of the internal jugular vein and external carotid artery. Same procedure in the area of the hypoglossal triangle. Here, too, extremely difficult, laborious dissection with severe scarring. Here too, long-distance dissection after exposure, neurolysis and relocation and re-embedding of the hypoglossal nerve. During dissection, the branches and branches of the internal jugular vein and external carotid artery are also protected. The final result is a neck dissection of levels I B, II, III, IV and V. Subsequent careful hemostasis. Then insertion of a Redon drain and two-layer wound closure and application of a pressure dressing. Then check the enoral findings again. If the wound is dry, the procedure is then completed. After a final consultation with the anesthesia colleagues, the patient goes to the recovery room after an unremarkable course of anesthesia and problem-free extubation. \ No newline at end of file diff --git a/199/InvasionFront_CD3_block13_x5_y4_patient199_0.json b/199/InvasionFront_CD3_block13_x5_y4_patient199_0.json new file mode 100644 index 0000000000000000000000000000000000000000..35b521a3432c6579e1f840e0182ac188f0859fb4 --- /dev/null +++ b/199/InvasionFront_CD3_block13_x5_y4_patient199_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 9320.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/199/InvasionFront_CD3_block13_x6_y4_patient199_1.json b/199/InvasionFront_CD3_block13_x6_y4_patient199_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a488cdc6dc8bd9a0eefa6d1c075590524711c608 --- /dev/null +++ b/199/InvasionFront_CD3_block13_x6_y4_patient199_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 9320.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/199/InvasionFront_CD8_block13_x5_y4_patient199_0.json b/199/InvasionFront_CD8_block13_x5_y4_patient199_0.json new file mode 100644 index 0000000000000000000000000000000000000000..661e8c6d66a2c9d6c19e549e5ea4be04e421ac22 --- /dev/null +++ b/199/InvasionFront_CD8_block13_x5_y4_patient199_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17215.9, + "Centroid Y µm": 11219.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/199/InvasionFront_CD8_block13_x6_y4_patient199_1.json b/199/InvasionFront_CD8_block13_x6_y4_patient199_1.json new file mode 100644 index 0000000000000000000000000000000000000000..417eab52fb40e7b5df11f5a3679d7cfdd68bf77e --- /dev/null +++ b/199/InvasionFront_CD8_block13_x6_y4_patient199_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 11344.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/199/TumorCenter_CD3_block13_x5_y4_patient199_0.json b/199/TumorCenter_CD3_block13_x5_y4_patient199_0.json new file mode 100644 index 0000000000000000000000000000000000000000..40c35694c40012b1a298c72956ab10cf3ab9d838 --- /dev/null +++ b/199/TumorCenter_CD3_block13_x5_y4_patient199_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17315.8, + "Centroid Y µm": 16616.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/199/TumorCenter_CD3_block13_x6_y4_patient199_1.json b/199/TumorCenter_CD3_block13_x6_y4_patient199_1.json new file mode 100644 index 0000000000000000000000000000000000000000..333a78c7377913221865102a419f450eb56b1c61 --- /dev/null +++ b/199/TumorCenter_CD3_block13_x6_y4_patient199_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19889.5, + "Centroid Y µm": 16791.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/199/TumorCenter_CD8_block13_x5_y4_patient199_0.json b/199/TumorCenter_CD8_block13_x5_y4_patient199_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cbf889c60f7fde095ed7943c15f5831253e5ac07 --- /dev/null +++ b/199/TumorCenter_CD8_block13_x5_y4_patient199_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 9744.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/199/TumorCenter_CD8_block13_x6_y4_patient199_1.json b/199/TumorCenter_CD8_block13_x6_y4_patient199_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3a804956acd1deb2352d8ef13d138fd3887a4bc9 --- /dev/null +++ b/199/TumorCenter_CD8_block13_x6_y4_patient199_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 9420.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/199/history_text.txt b/199/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..96ee30150f44bdcc42b871e855cc179aee07e262 --- /dev/null +++ b/199/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT4a cN2b hypopharyngeal carcinoma on the right was histologically confirmed during a panendoscopy <2014>. Hypopharyngeal carcinoma in the area of the right piriform sinus with infiltration of the laryngeal skeleton. In our interdisciplinary tumor conference, the primary surgical procedure with laryngectomy and partial pharyngectomy was recommended. In the preoperative course, the right-sided lymph node metastases were significantly enlarged. The CT scan performed immediately before the operation showed a primary tumor that was largely unchanged in size and now had a cN3 neck status with a lymph node metastasis measuring over 10 cm on clinical and computed tomography as a conglomerate on the right. There was still no evidence of distant metastasis, so that the primary surgical procedure could be confirmed. \ No newline at end of file diff --git a/199/icd_codes.txt b/199/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/199/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/199/ops_codes.txt b/199/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9464d8bd49049ef73244b9f8022e0bb807381a10 --- /dev/null +++ b/199/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit gestieltem Fernlappen[5-303.15 ] Gestielte regionale Lappenplastik mit Fernlappen an der Brustwand[5-906.2a ] Radikale erweiterte Neck dissection in 5 Regionen[5-403.31 R] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 L] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/199/patient_clinical_data.json b/199/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..64f6cb32d4b2d22b2ad108b673ce946032ba553c --- /dev/null +++ b/199/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 46, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 39, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/199/patient_pathological_data.json b/199/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..eb897086cf98818494db077a08766b1d06f26048 --- /dev/null +++ b/199/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "199", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 10.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/199/surgery_description.txt b/199/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..67764b163ee13b42c62c53e292f7cb9b2cf18175 --- /dev/null +++ b/199/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Defect coverage, Pedicled flap (Pectoralis major) diff --git a/199/surgery_report.txt b/199/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b7b600e2540ba0b877a9be619294fa23231dadcf --- /dev/null +++ b/199/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and bronchoscopic intubation by the anesthesia colleagues and preparation of the patient, the first step is positioning. A pharyngo/laryngoscopy is performed. The carcinoma can be seen in the area of the right piriform sinus, which is completely filled in, with fixation of the laryngeal skeleton via the medial wall of the piriform sinus. Endolaryngeal free conditions with clear infiltration of the right hemilarynx on computed tomography and palpation. Confirmation of the indication for laryngectomy. Clinically, there is a monstrous mass on the right with an area of non-displaceable skin measuring approx. 4 x 5 cm. In the area of the remaining mucous membranes, the esophageal entrance is free, as is the posterior wall of the hypopharynx and the entire left side. The patient is now repositioned. Injection of xylocaine with the addition of adrenaline. Form an apron flap by cutting around the palpatorily infiltrated skin. Widening of the incision on the right side around the lobule with infiltration of the caudal parotid pole. On the left side, regular elevation of the apron flap with dissection of the platysma. In the area of the metastasis, careful dissection of the otherwise healthy skin in the surrounding area. In some cases, however, significant inflammatory changes to the skin with redness and vulnerability. Skin incision around the lobule. Dissection of the lobule, exposure of the anterior wall of the auditory canal and exposure of the mastoid. After raising the apron flap, start with the left-sided neck dissection to secure the healthy vessels. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle. Exposure of the submandibular gland, including the caudal capsule. Exposure of the digastric muscle, removal of the anterior neck preparation with careful protection of the facial vein, the superior thyroid artery, the cervical artery and the hypoglossal nerve. Free preparation of the internal jugular vein. Exposure of the accessorius nerve. Dissection of the accessorius triangle with careful protection and dissection of level Va with careful protection of the cervical plexus branches. Finally, with dry wound conditions, exposure of the left side of the hyoid and release of the hyoid, exposure and skeletonization of the larynx, release of the left-sided laryngeal horn with release of the left-sided piriform sinus. Dissection of the left lobe of the thyroid gland, exposure of the cricoid cartilage and trachea. Now turn to the opposite side. Successive development of the monstrous mass. Caudal exposure of the internal jugular vein, common carotid artery and vagus nerve. Subsequent resection of the mass, which extensively infiltrates the scalenus and paravertebral musculature. Complete infiltration of the cervical plexus roots. The accessory nerve is not visible, the mass can be lifted off the mastoid with the periosteum. Cranially, the tumor clearly infiltrates the caudal part of the parotid gland. Longitudinal approach to the mandible, the submandibular gland is free, but a further metastatic conglomerate can be seen in level Ib after visualization of the pointer. Identification of the facial nerve trunk, which is otherwise left in the remaining glandular part with its subdivision. Clear infiltration of the oral branch, which is resected. Exposure of the mandible, but no infiltration here. The periosteum is also not infiltrated in the area of the mandible. Resection of the conglomerate of Ib with resection of the submandibular gland. Protection of the lingual nerve, which is not infiltrated. Exposure of the intact carotid bulb. Now clear infiltration of the vagus nerve and the hypoglossal nerve. Resection of both nerves as well. Subtotal resection of the external carotid artery branches, the internal carotid artery can be detached from the tumor. Certainly no infiltration here. Finally, after resection of the metastases, some of which extend far into the paravertebral region with surrounding muscle, removal of the conglomerate in toto. This can be accomplished by leaving a small tissue bridge to the primary. No open tumor here. The tumor is now exposed on the right side of the larynx, the thyroid lobe is detached, the piriform sinus is left completely intact on the larynx, the tumor is inserted enorally at the level of the epiglottis, successive development with sparing expansion on the left side in the area of the aryepiglottic fold. Now a good overview of the tumor, which is confirmed as described above. Removal of the tumor with a safety margin of 1.5 cm in the area of the pharyngeal side wall. Postcricoid no growth, also no extension towards the esophageal entrance as described above. Resection of the tumor macroscopically completely in sano, including the laryngeal skeleton, no infiltration of the cricoid cartilage or trachea. At the mucosal level, covering of the tumor with marginal samples, in addition, after close inspection of the pharyngeal tube, small punctiform lesions can now be seen, remote from the tumor in the area of the posterior pharyngeal wall and on the left side. Slightly indurated on palpation and macroscopically unclear. Excisional biopsy of one of the lesions in case of possible differential diagnosis of satellite metastasis. In the frozen section diagnostics, all tumor-covering edge samples show carcinoma and dysplasia free, so that an R0 situation is present here. The tumor.................... lesions are lymphoepithelial hyperplasia with at most low-grade dysplasia after complete embedding, so that satellite metastasis can be ruled out here. After completion of the tumor resection, the caudal pharyngeal tube area now shows a sufficiently wide and regular esophageal entrance. Cranially in the area of the pharyngeal side wall at the transition to the base of the tongue, the conditions are somewhat narrow. In conjunction with the completely radical resection of the right-sided soft tissues of the neck with the only remaining common carotid artery, the indication for elevation of a myocutaneous pectoralis major flap with a large muscle portion for soft tissue coverage of the pharyngeal tube and the soft tissues of the neck was established. A left lateral myotomy is performed in the area of the upper esophageal sphincter, an 8.0 mm ............. is placed in the cranial tracheal insertion area; this is successful and without any problems, the anterior wall of the trachea is shortened to position the provost prosthesis at a height, and then the left sternal insertion of the sternocleidomastoid muscle is removed. Marking paramillary of the pectoralis major flap, elevation of a 6.5 x 4.5 cm spindle for insertion in the base of the tongue. Extensive dissection of the pectoralis major muscle and subtotal resection of the muscle. Development of a large-area muscle flap, complete isolation on the vascular pedicle after reliable identification of the vascular bundle. After complete release of the flap, cranial tunneling, insertion of the excellent vital skin island into the pharyngeal defect with closure of the defect, this is achieved without tension and sufficiently. Adaptation of the muscle to the left-sided infrahyoid musculature as well as to the right-sided paravertebral muscle stumps, but good soft tissue coverage of the entire pharyngeal tube, which is now completely covered, as well as coverage of the carotid artery and good soft tissue padding. Careful hemostasis in the chest area. Insertion of two 10-gauge Redon drains and careful, strong wound closure. Then fold back the apron flap, successive suturing of the tracheostoma and careful two-layer wound closure with adaptation of the resected right-sided skin with as little tension as possible. Finally, reintubation to a size 10 low cuff cannula, which is suture-fixed, and completion of the procedure without any indication of complications. Conclusion: Intraoperative R0 resected cT4a cN3 right hypopharyngeal carcinoma with multilocular and ..................... deep right cervical metastasis with partial radical parotidectomy and resection of the hypoglossal nerve and vagus nerve. Due to the extent of the tumor, an escalation of adjuvant therapy should be discussed. Please carry out an X-ray pelvis on the 10th postoperative day. \ No newline at end of file diff --git a/200/InvasionFront_CD3_block4_x5_y3_patient200_0.json b/200/InvasionFront_CD3_block4_x5_y3_patient200_0.json new file mode 100644 index 0000000000000000000000000000000000000000..78e914597f010f4f6d552f87153f3f55d309941f --- /dev/null +++ b/200/InvasionFront_CD3_block4_x5_y3_patient200_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19139.9, + "Centroid Y µm": 13942.6, + "Num Detections": 26386, + "Num Negative": 22312, + "Num Positive": 4074, + "Positive %": 15.44, + "Num Positive per mm^2": 1576.3 + } +} \ No newline at end of file diff --git a/200/InvasionFront_CD3_block4_x6_y3_patient200_1.json b/200/InvasionFront_CD3_block4_x6_y3_patient200_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c6d4293c5cc8b0475299f01c466a77842eec3d95 --- /dev/null +++ b/200/InvasionFront_CD3_block4_x6_y3_patient200_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21763.5, + "Centroid Y µm": 14042.6, + "Num Detections": 23483, + "Num Negative": 18984, + "Num Positive": 4499, + "Positive %": 19.16, + "Num Positive per mm^2": 1770.0 + } +} \ No newline at end of file diff --git a/200/InvasionFront_CD8_block4_x5_y3_patient200_0.json b/200/InvasionFront_CD8_block4_x5_y3_patient200_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b48f8d8b6906fd812d7c0d25ee0947451f85c0e8 --- /dev/null +++ b/200/InvasionFront_CD8_block4_x5_y3_patient200_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 12468.4, + "Num Detections": 26416, + "Num Negative": 23235, + "Num Positive": 3181, + "Positive %": 12.04, + "Num Positive per mm^2": 1211.8 + } +} \ No newline at end of file diff --git a/200/InvasionFront_CD8_block4_x6_y3_patient200_1.json b/200/InvasionFront_CD8_block4_x6_y3_patient200_1.json new file mode 100644 index 0000000000000000000000000000000000000000..47db48623f2aeca4ecbdf2dbd668a03c1ddbcd8a --- /dev/null +++ b/200/InvasionFront_CD8_block4_x6_y3_patient200_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 12468.4, + "Num Detections": 24452, + "Num Negative": 22226, + "Num Positive": 2226, + "Positive %": 9.104, + "Num Positive per mm^2": 864.48 + } +} \ No newline at end of file diff --git a/200/TumorCenter_CD3_block4_x5_y3_patient200_0.json b/200/TumorCenter_CD3_block4_x5_y3_patient200_0.json new file mode 100644 index 0000000000000000000000000000000000000000..96c1a5f0fb30f05fef61ed876458ea59bae2f4a9 --- /dev/null +++ b/200/TumorCenter_CD3_block4_x5_y3_patient200_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16166.4, + "Centroid Y µm": 7745.9, + "Num Detections": 30309, + "Num Negative": 28155, + "Num Positive": 2154, + "Positive %": 7.107, + "Num Positive per mm^2": 789.85 + } +} \ No newline at end of file diff --git a/200/TumorCenter_CD3_block4_x6_y3_patient200_1.json b/200/TumorCenter_CD3_block4_x6_y3_patient200_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c131d7db49cabf17ad960bd6c10ceeb97b05e052 --- /dev/null +++ b/200/TumorCenter_CD3_block4_x6_y3_patient200_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 7820.9, + "Num Detections": 28775, + "Num Negative": 24554, + "Num Positive": 4221, + "Positive %": 14.67, + "Num Positive per mm^2": 1506.0 + } +} \ No newline at end of file diff --git a/200/TumorCenter_CD8_block4_x5_y3_patient200_0.json b/200/TumorCenter_CD8_block4_x5_y3_patient200_0.json new file mode 100644 index 0000000000000000000000000000000000000000..41021110a9886413ba17f1db229868cf9fd79358 --- /dev/null +++ b/200/TumorCenter_CD8_block4_x5_y3_patient200_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17140.9, + "Centroid Y µm": 7795.9, + "Num Detections": 32600, + "Num Negative": 31442, + "Num Positive": 1158, + "Positive %": 3.552, + "Num Positive per mm^2": 414.77 + } +} \ No newline at end of file diff --git a/200/TumorCenter_CD8_block4_x6_y3_patient200_1.json b/200/TumorCenter_CD8_block4_x6_y3_patient200_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b2340951330a4f84d93f775b65bc2ee0a555705b --- /dev/null +++ b/200/TumorCenter_CD8_block4_x6_y3_patient200_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19714.6, + "Centroid Y µm": 7995.8, + "Num Detections": 29387, + "Num Negative": 26699, + "Num Positive": 2688, + "Positive %": 9.147, + "Num Positive per mm^2": 959.08 + } +} \ No newline at end of file diff --git a/200/history_text.txt b/200/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d56c00e21b27ae87bc7164b43ac112916910b17a --- /dev/null +++ b/200/history_text.txt @@ -0,0 +1 @@ +A lymph node had been removed externally from the patient, whereupon the metastasis of a squamous cell carcinoma had appeared. The patient now underwent the above-mentioned procedure to search for the tumor. \ No newline at end of file diff --git a/200/icd_codes.txt b/200/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adab28f0b88ba31c5bb4895a3d4f3034f2967b3e --- /dev/null +++ b/200/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] \ No newline at end of file diff --git a/200/ops_codes.txt b/200/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d483d90d39a73e7ac3cb6b7a5fff8c836760e7b7 --- /dev/null +++ b/200/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Rhinoskopie[1-612 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/200/patient_clinical_data.json b/200/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..32aab23eae3744936079abb4409dbe008b43acb3 --- /dev/null +++ b/200/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 72, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/200/patient_pathological_data.json b/200/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..23735536249e95a93a8d4b8f2bad66e408427352 --- /dev/null +++ b/200/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "200", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/200/surgery_description.txt b/200/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..419c3a5f916564321e2350c16a9456731b04ba83 --- /dev/null +++ b/200/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy, Panendoscopy diff --git a/200/surgery_report.txt b/200/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9f53d09c67e9230c4f74ef83a20a8b2be8e10b0c --- /dev/null +++ b/200/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Induction of intubation anesthesia. Including laryngoscopic adjustment of the glottic plane and inspection of the glottis and subglottis up to the trachea and main bronchi, where there is no evidence of tumor growth. The patient is then intubated by the anesthesia colleague without any problems. The patient is repositioned for flexible esophagogastroscopy. The flexible instrument is inserted into the oesophagus without any problems and the stomach is visualized, where numerous polyps can be seen, particularly in the gastric antrum. These should definitely be investigated further by an internist. Mirroring back and inspection of the esophagus, which is unremarkable throughout. Reposition the patient and inspect the oral cavity and oropharynx. This reveals an indurated tonsil on the right side with very slight exophytic areas. The other areas are unremarkable. Insertion of the mouth retractor. The suspected infiltration of the right tonsil by a carcinoma is confirmed. Insertion of the velotraction and inspection of the nasopharynx, which is unremarkable. Removal of the mouthpiece. Further screening of the hypopharynx and re-inspection of the larynx. All areas are inconspicuous here. Re-insertion of the tonsil plug and performance of the tumor tonsillectomy. Resection of the anterior palate with the electric needle. Exposure of the upper pole vessels. These are all coagulated. Exposure of the pharyngeal muscles. Resection of the tonsil caudally strictly along the pharyngeal musculature. This also involves partial resection of the posterior palatal arch. The resection is performed on the pharyngeal musculature up to beyond the lower pole of the tonsil, towards the base of the tongue. There, the tumor preparation is deposited with a portion of the tongue base tonsil. Suture marking of the cranial and caudal deposition area and removal of a marginal sample from the anterior and posterior palatal arch. All specimens are sent for frozen section diagnostics and are found to be tumor-free intraoperatively. The staging reveals massive infiltrates of a tonsillar carcinoma, which is apparently removed in toto here. A mucosoplasty was performed. After subtle hemostasis using bipolar coagulation and ligation of a large artery at the caudal tonsil pole, insertion of hydrogen swabs and rinsing with Ringer's solution, the wound is dry. Completion of the procedure. Final consultation with the anesthesiologist. A T1 tonsillar carcinoma is found on the right. The neck dissection of the right side must then be completed in a two-stage procedure. \ No newline at end of file diff --git a/201/InvasionFront_CD3_block2_x5_y3_patient201_0.json b/201/InvasionFront_CD3_block2_x5_y3_patient201_0.json new file mode 100644 index 0000000000000000000000000000000000000000..07ccc9a19194b69823b3d7464566ca04ea4d63ff --- /dev/null +++ b/201/InvasionFront_CD3_block2_x5_y3_patient201_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 21063.8, + "Num Detections": 17772, + "Num Negative": 15722, + "Num Positive": 2050, + "Positive %": 11.53, + "Num Positive per mm^2": 1046.1 + } +} \ No newline at end of file diff --git a/201/InvasionFront_CD3_block2_x6_y3_patient201_1.json b/201/InvasionFront_CD3_block2_x6_y3_patient201_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4d1b5d14e7d860eee44c2c6d826262f71034e63e --- /dev/null +++ b/201/InvasionFront_CD3_block2_x6_y3_patient201_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21538.6, + "Centroid Y µm": 21113.8, + "Num Detections": 12622, + "Num Negative": 10739, + "Num Positive": 1883, + "Positive %": 14.92, + "Num Positive per mm^2": 1442.4 + } +} \ No newline at end of file diff --git a/201/InvasionFront_CD8_block2_x5_y3_patient201_0.json b/201/InvasionFront_CD8_block2_x5_y3_patient201_0.json new file mode 100644 index 0000000000000000000000000000000000000000..67e30970ff8d5bd746ab68ad3ac69b7805e1e15d --- /dev/null +++ b/201/InvasionFront_CD8_block2_x5_y3_patient201_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17690.6, + "Centroid Y µm": 8795.3, + "Num Detections": 18728, + "Num Negative": 18038, + "Num Positive": 690, + "Positive %": 3.684, + "Num Positive per mm^2": 355.1 + } +} \ No newline at end of file diff --git a/201/InvasionFront_CD8_block2_x6_y3_patient201_1.json b/201/InvasionFront_CD8_block2_x6_y3_patient201_1.json new file mode 100644 index 0000000000000000000000000000000000000000..410f547bd0e55c7735763af5db744714ea3e749c --- /dev/null +++ b/201/InvasionFront_CD8_block2_x6_y3_patient201_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20389.2, + "Centroid Y µm": 8770.4, + "Num Detections": 11794, + "Num Negative": 10505, + "Num Positive": 1289, + "Positive %": 10.93, + "Num Positive per mm^2": 1048.5 + } +} \ No newline at end of file diff --git a/201/TumorCenter_CD3_block2_x5_y3_patient201_0.json b/201/TumorCenter_CD3_block2_x5_y3_patient201_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b6732e82c5241f5de383fdc60152f773d3e65483 --- /dev/null +++ b/201/TumorCenter_CD3_block2_x5_y3_patient201_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16716.1, + "Centroid Y µm": 7471.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/201/TumorCenter_CD3_block2_x6_y3_patient201_1.json b/201/TumorCenter_CD3_block2_x6_y3_patient201_1.json new file mode 100644 index 0000000000000000000000000000000000000000..90b9b5de85a520957bf4855f636156e760f34a05 --- /dev/null +++ b/201/TumorCenter_CD3_block2_x6_y3_patient201_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 7646.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/201/TumorCenter_CD8_block2_x5_y3_patient201_0.json b/201/TumorCenter_CD8_block2_x5_y3_patient201_0.json new file mode 100644 index 0000000000000000000000000000000000000000..64c48dce8a61fe351df045a12cb64a2767ce38d6 --- /dev/null +++ b/201/TumorCenter_CD8_block2_x5_y3_patient201_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17965.5, + "Centroid Y µm": 6971.3, + "Num Detections": 10721, + "Num Negative": 9982, + "Num Positive": 739, + "Positive %": 6.893, + "Num Positive per mm^2": 629.54 + } +} \ No newline at end of file diff --git a/201/TumorCenter_CD8_block2_x6_y3_patient201_1.json b/201/TumorCenter_CD8_block2_x6_y3_patient201_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f5c2156ac8a69913fc090f1bb4e753bd93256fce --- /dev/null +++ b/201/TumorCenter_CD8_block2_x6_y3_patient201_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20489.2, + "Centroid Y µm": 6946.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/201/history_text.txt b/201/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..50346373409631be621e92b7a9fcbf7bd0fefbcd --- /dev/null +++ b/201/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT1-2 cN2b oropharyngeal carcinoma on the right side. There is now an indication for transoral tumor resection and neck dissection. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/201/icd_codes.txt b/201/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2f26c067e0a1de49d00c7658fcf298e477b7b358 --- /dev/null +++ b/201/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 R] Neubildung bösartig sekundär und onA Lymphknoten Kopf Gesicht Hals[C77.0 R] \ No newline at end of file diff --git a/201/ops_codes.txt b/201/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fad113eda9f53d381d78491bba8f1c61052666a3 --- /dev/null +++ b/201/ops_codes.txt @@ -0,0 +1 @@ +Zungentumorexzision[5-250.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 R] \ No newline at end of file diff --git a/201/patient_clinical_data.json b/201/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fd93b2dc03d8dbb788ab54683e1d4fd2b8cdf917 --- /dev/null +++ b/201/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 82, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/201/patient_pathological_data.json b/201/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f1261825d6dbc9733cc7563154d980a1e704ceaf --- /dev/null +++ b/201/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "201", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 9.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/201/surgery_description.txt b/201/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1df11348de6faddc73d52b836019130853debd2a --- /dev/null +++ b/201/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Neck dissection diff --git a/201/surgery_report.txt b/201/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e753e20df1a0f5c98cb991ab8a3ebd78df810f99 --- /dev/null +++ b/201/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesiologist. Induction of anesthesia. Intubation of the patient. First inspection of the tumor area. This is located in the area of the right-sided base of the tongue and does not extend to the midline. Further tumor extensions run over the glossotonsillar groove onto the anterior palatal arch. Insertion of the mouth retractor according to Jennings. Tongue suture. Insertion of the Bruenings hook. Successive resection of the tumor using the electric needle and pointed scissors under palpatory control. Resection of parts of the anterior palatal arch, the glossotonsillar groove and the base of the tongue. Exposure of smaller branches of the lingual artery. These can be easily coagulated bipolarly. The tumor specimen is then thread-marked (lateral, medial, wound base) for frozen section diagnostics. In the meantime, reposition the patient for neck dissection. First, skin spray disinfection and infiltration anesthesia. Abjode the surgical site and cover it sterilely. Marking of the planned incision in the area of the old scar. Sharp cutting of the cutis and subcutis. Exposure of the front edge of the sternocleidomastoid muscle. Overall, clearly scarred changes due to the previous operation. Exposure of the omohyoid muscle as the caudal border. Exposure of the cervical vascular sheath. The scarred changes make dissection conditions considerably more difficult. Numerous cystic metastases can be seen lateral to the cervical vascular sheath. Cranial dissection. Finding the posterior digastric venter above the scar block. Exposure and protection of the accessorius nerve. Displacement and at the end of the operation re-embedding of the accessory nerve in the sense of a neurolysis. Subsequent attempt to develop the lateral neck preparation. However, it became apparent that the metastatic conglomerate in the area of the venous angle was infiltrating the vein. The decision is therefore made to resect the internal jugular vein. Exposure of the cranial part of the internal jugular vein medial to the digastric muscle. Subsequent exposure of the common carotid artery, the external and internal bifurcation. Exposure and protection of the vagus nerve. Exposure of the hypoglossal nerve. Displacement and, at the end of the operation, re-embedding of the vagus nerve and hypoglossal nerve in the sense of neurolysis. Ligation of the internal jugular vein cranially and caudally. Creation of a second ligature. Dissection of the internal jugular vein. Subsequent removal of the lateral neck specimen together with the attached numerous cystically altered lymph node metastases. The accessorius nerve and the plexus branches are spared. Development of the medial neck preparation. At the end of the operation, meticulous hemostasis using bipolar coagulation. Wound irrigation with H2O2 and Ringer's solution. Insertion of a 10 Redon drain. Subcutaneous suture, skin suture and application of a wound dressing. In the meantime, telephone announcement of the frozen section diagnosis. In the area of the lateral margin in the direction of the anterior palatal arch and the glossotonsillar groove, the tumor is edge-forming. For this reason, appropriate resectates are taken here. At the end of the operation, the tumor is clinically R0. Once again meticulous hemostasis using bipolar coagulation. Final consultation with the anesthesiologist. Completion of the operation without complications. \ No newline at end of file diff --git a/202/InvasionFront_CD3_block19_x1_y2_patient202_0.json b/202/InvasionFront_CD3_block19_x1_y2_patient202_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e2eee3f1d20e749802e4c9fb2495beeda99addbe --- /dev/null +++ b/202/InvasionFront_CD3_block19_x1_y2_patient202_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5572.0, + "Centroid Y µm": 7021.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/202/InvasionFront_CD3_block19_x2_y2_patient202_1.json b/202/InvasionFront_CD3_block19_x2_y2_patient202_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0e2b3e600f3002e9428f4b0dd477698a0c01d702 --- /dev/null +++ b/202/InvasionFront_CD3_block19_x2_y2_patient202_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8083.2, + "Centroid Y µm": 7233.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/202/InvasionFront_CD8_block19_x1_y2_patient202_0.json b/202/InvasionFront_CD8_block19_x1_y2_patient202_0.json new file mode 100644 index 0000000000000000000000000000000000000000..986c455558ff315b24821c1710248b297b66f2a8 --- /dev/null +++ b/202/InvasionFront_CD8_block19_x1_y2_patient202_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4797.5, + "Centroid Y µm": 14742.2, + "Num Detections": 18184, + "Num Negative": 16039, + "Num Positive": 2145, + "Positive %": 11.8, + "Num Positive per mm^2": 931.04 + } +} \ No newline at end of file diff --git a/202/InvasionFront_CD8_block19_x2_y2_patient202_1.json b/202/InvasionFront_CD8_block19_x2_y2_patient202_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b7a5e3442e90c66ab377a4889ae480691034863d --- /dev/null +++ b/202/InvasionFront_CD8_block19_x2_y2_patient202_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7346.1, + "Centroid Y µm": 14892.1, + "Num Detections": 20497, + "Num Negative": 19339, + "Num Positive": 1158, + "Positive %": 5.65, + "Num Positive per mm^2": 499.34 + } +} \ No newline at end of file diff --git a/202/TumorCenter_CD3_block19_x1_y2_patient202_0.json b/202/TumorCenter_CD3_block19_x1_y2_patient202_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4dceb5332e10171743b117b3a73bb82165e56ee1 --- /dev/null +++ b/202/TumorCenter_CD3_block19_x1_y2_patient202_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 7496.0, + "Num Detections": 14898, + "Num Negative": 12942, + "Num Positive": 1956, + "Positive %": 13.13, + "Num Positive per mm^2": 954.47 + } +} \ No newline at end of file diff --git a/202/TumorCenter_CD3_block19_x2_y2_patient202_1.json b/202/TumorCenter_CD3_block19_x2_y2_patient202_1.json new file mode 100644 index 0000000000000000000000000000000000000000..291deecf6f8c633c637ff9821b39b6fed74622d2 --- /dev/null +++ b/202/TumorCenter_CD3_block19_x2_y2_patient202_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5647.0, + "Centroid Y µm": 7096.2, + "Num Detections": 17021, + "Num Negative": 14332, + "Num Positive": 2689, + "Positive %": 15.8, + "Num Positive per mm^2": 1228.5 + } +} \ No newline at end of file diff --git a/202/TumorCenter_CD8_block19_x1_y2_patient202_0.json b/202/TumorCenter_CD8_block19_x1_y2_patient202_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d52af43c36004ab33152f6a9142c3dabaf9532a --- /dev/null +++ b/202/TumorCenter_CD8_block19_x1_y2_patient202_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6354.0, + "Centroid Y µm": 16472.6, + "Num Detections": 12367, + "Num Negative": 11352, + "Num Positive": 1015, + "Positive %": 8.207, + "Num Positive per mm^2": 518.76 + } +} \ No newline at end of file diff --git a/202/TumorCenter_CD8_block19_x2_y2_patient202_1.json b/202/TumorCenter_CD8_block19_x2_y2_patient202_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b62fc528d9554ed88632bd926c170da48045562b --- /dev/null +++ b/202/TumorCenter_CD8_block19_x2_y2_patient202_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8715.4, + "Centroid Y µm": 16391.8, + "Num Detections": 16617, + "Num Negative": 14219, + "Num Positive": 2398, + "Positive %": 14.43, + "Num Positive per mm^2": 1095.8 + } +} \ No newline at end of file diff --git a/202/history_text.txt b/202/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4e0bab75c89a7ffcf0c9775b40827b9fbecf986f --- /dev/null +++ b/202/history_text.txt @@ -0,0 +1 @@ +Mirror endoscopic mass of the anterior right glottis. After panendo and sampling with the finding of a CIS at the transition to an exophytic, moderately differentiated squamous cell carcinoma, thus indication for the above-mentioned procedure. \ No newline at end of file diff --git a/202/icd_codes.txt b/202/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2508fd96c85f687daa2a5e3bab2031092ac465a7 --- /dev/null +++ b/202/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/202/ops_codes.txt b/202/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..28ec94a85a60746fe549b44b51303ebac775e9e9 --- /dev/null +++ b/202/ops_codes.txt @@ -0,0 +1 @@ +Endolaryngeale Chordektomie[5-302.1 ] Partielle Laryngektomie endoskopische Laserresektion[5-302.5 ] \ No newline at end of file diff --git a/202/patient_clinical_data.json b/202/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ce7275718ab40830e0df1d904452b2d5eade3f10 --- /dev/null +++ b/202/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 30, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/202/patient_pathological_data.json b/202/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..379da8eadf8d0649a66723f29777cc88ef4295dd --- /dev/null +++ b/202/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "202", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/202/surgery_description.txt b/202/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b45ea1174e5848dbc7e53358c76517376cec36f6 --- /dev/null +++ b/202/surgery_description.txt @@ -0,0 +1 @@ +Laser resection diff --git a/202/surgery_report.txt b/202/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a0425d6eec9e46a9293fa21e256c50d9a2d6d6e --- /dev/null +++ b/202/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues. Subsequent positioning by the surgeon. Entry with the Kleinsasser D-tube and adjustment of the endolarynx. When pressure is applied to the larynx, the exophytic mass can be seen in the anterior third of the right vocal fold. This is now adjusted and carefully cut around using a laser and removed in toto. It is sent for final histology. In addition, samples are taken from the anterior incision area in the lateral and posterior incision area, all of which are found to be tumor-free in the frozen section. A complete resection of the tumor can therefore be assumed. Hemostasis using suprarenin-soaked swabs. Hardly any swelling at the end of the frozen section, so that a tracheotomy can be dispensed with. Completion of the procedure with no indication of complications. Control MLE planned in 8 weeks. \ No newline at end of file diff --git a/203/InvasionFront_CD3_block16_x3_y12_patient203_0.json b/203/InvasionFront_CD3_block16_x3_y12_patient203_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c7764decb060c6d069785d5ebe443edd632c1fea --- /dev/null +++ b/203/InvasionFront_CD3_block16_x3_y12_patient203_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11660.5, + "Centroid Y µm": 34281.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/203/InvasionFront_CD3_block16_x4_y12_patient203_1.json b/203/InvasionFront_CD3_block16_x4_y12_patient203_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f3fb32d7999250c6c0dd9fd5fef563d0e7f0ee49 --- /dev/null +++ b/203/InvasionFront_CD3_block16_x4_y12_patient203_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14125.9, + "Centroid Y µm": 34281.8, + "Num Detections": 9520, + "Num Negative": 9042, + "Num Positive": 478, + "Positive %": 5.021, + "Num Positive per mm^2": 387.79 + } +} \ No newline at end of file diff --git a/203/InvasionFront_CD8_block16_x3_y12_patient203_0.json b/203/InvasionFront_CD8_block16_x3_y12_patient203_0.json new file mode 100644 index 0000000000000000000000000000000000000000..600a1d24e5ea815cd388f32e0fb992199a8e4960 --- /dev/null +++ b/203/InvasionFront_CD8_block16_x3_y12_patient203_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10615.9, + "Centroid Y µm": 29186.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/203/InvasionFront_CD8_block16_x4_y12_patient203_1.json b/203/InvasionFront_CD8_block16_x4_y12_patient203_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a285287cceb1e06fa14ce1247582bd471ed457e6 --- /dev/null +++ b/203/InvasionFront_CD8_block16_x4_y12_patient203_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13125.5, + "Centroid Y µm": 28954.7, + "Num Detections": 9490, + "Num Negative": 9349, + "Num Positive": 141, + "Positive %": 1.486, + "Num Positive per mm^2": 126.03 + } +} \ No newline at end of file diff --git a/203/TumorCenter_CD8_block16_x3_y12_patient203_0.json b/203/TumorCenter_CD8_block16_x3_y12_patient203_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c98c758d6d1aac4c2d692c625003efbe30de0bb1 --- /dev/null +++ b/203/TumorCenter_CD8_block16_x3_y12_patient203_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 30383.9, + "Num Detections": 6976, + "Num Negative": 6436, + "Num Positive": 540, + "Positive %": 7.741, + "Num Positive per mm^2": 721.37 + } +} \ No newline at end of file diff --git a/203/TumorCenter_CD8_block16_x4_y12_patient203_1.json b/203/TumorCenter_CD8_block16_x4_y12_patient203_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a85dc77d2570278dc4d1efdc0b56fd104558f5ba --- /dev/null +++ b/203/TumorCenter_CD8_block16_x4_y12_patient203_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13068.1, + "Centroid Y µm": 30533.8, + "Num Detections": 11550, + "Num Negative": 11347, + "Num Positive": 203, + "Positive %": 1.758, + "Num Positive per mm^2": 151.37 + } +} \ No newline at end of file diff --git a/203/history_text.txt b/203/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1bc92a8ba4c85521197536f01b240d1676429be9 --- /dev/null +++ b/203/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma in the left glottis area. Carcinoma in the area of the middle approx. 60 % of the vocal fold. Therefore, the above-mentioned surgery is now indicated. \ No newline at end of file diff --git a/203/icd_codes.txt b/203/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9a361144c56ac32017ad9d50ab1cac2edbe9be17 --- /dev/null +++ b/203/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] Bösartige Neubildung der Glottis[C32.0 L] \ No newline at end of file diff --git a/203/ops_codes.txt b/203/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f30a355c30d0294f2ee4defe16ee65910d6db94 --- /dev/null +++ b/203/ops_codes.txt @@ -0,0 +1 @@ +Laserresektion Larynxgewebe mit Stützlaryngoskopie[5-302.5 ] Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] Verwendung von CO2-Laser (Zusatzkode)[5-985.1 ] \ No newline at end of file diff --git a/203/patient_clinical_data.json b/203/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bc60289012507380551755f7226628f4e9de56c3 --- /dev/null +++ b/203/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 56, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/203/patient_pathological_data.json b/203/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a9cb56a71d87dcb274441061e53cf18931cce8ae --- /dev/null +++ b/203/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "203", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/203/surgery_description.txt b/203/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c811c2c16e3ac70af7d193d281a817bab8820ebb --- /dev/null +++ b/203/surgery_description.txt @@ -0,0 +1 @@ +Laser resection of glottis carcinoma diff --git a/203/surgery_report.txt b/203/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..26054a2af9238cda702d58192fb0850076a63102 --- /dev/null +++ b/203/surgery_report.txt @@ -0,0 +1 @@ +First of all, after intubation by anesthesia and placement of a laser tube, insert a mouth guard and insert a size C small bore tube. Adjustment of the tumor, which is slightly difficult. In the end, however, the tumor can be adjusted well. The tumor is then cut around on all sides with a safety margin of 3-4 mm. Resection extends to the front of the cartilage, whereby all tissue is also resected. After dorsal resection up to the arytenoid cartilage. Laterally, resection of the entire vocal fold or parts of the paraglottic musculature. After removal of the tumor, which is sent for final diagnosis, removal of marginal samples. Basal, subglottic, supraglottic, anterior from the anterior commissure and posterior from the arytenoid region. Here, all tumor margin samples are free of carcinoma in the frozen section. Subsequent careful hemostasis. End the procedure with an absolutely hemorrhage-free site. Discuss the procedure again after receiving the final histology. In any case with R0 resection, also in the final findings, follow-up endoscopy in 8-12 weeks. \ No newline at end of file diff --git a/204/InvasionFront_CD3_block11_x3_y7_patient204_0.json b/204/InvasionFront_CD3_block11_x3_y7_patient204_0.json new file mode 100644 index 0000000000000000000000000000000000000000..381d3a59aac70d1ea38fcc3f5ef27bd7913217f8 --- /dev/null +++ b/204/InvasionFront_CD3_block11_x3_y7_patient204_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10694.3, + "Centroid Y µm": 17041.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/204/InvasionFront_CD3_block11_x4_y7_patient204_1.json b/204/InvasionFront_CD3_block11_x4_y7_patient204_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0b20ce23351bdf3ca2cb805847787f194bb1f5d2 --- /dev/null +++ b/204/InvasionFront_CD3_block11_x4_y7_patient204_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13193.0, + "Centroid Y µm": 16966.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/204/InvasionFront_CD8_block11_x3_y7_patient204_0.json b/204/InvasionFront_CD8_block11_x3_y7_patient204_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f1157d5e35e51433da03e30b958568c4613bfcfe --- /dev/null +++ b/204/InvasionFront_CD8_block11_x3_y7_patient204_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.3, + "Centroid Y µm": 28017.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/204/InvasionFront_CD8_block11_x4_y7_patient204_1.json b/204/InvasionFront_CD8_block11_x4_y7_patient204_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3425df287a3852b40cde2423b2911e09752d7324 --- /dev/null +++ b/204/InvasionFront_CD8_block11_x4_y7_patient204_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16007.2, + "Centroid Y µm": 28045.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/204/TumorCenter_CD3_block11_x3_y7_patient204_0.json b/204/TumorCenter_CD3_block11_x3_y7_patient204_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7f49439adea8f7765516bec01500dfbd1cc1b3ee --- /dev/null +++ b/204/TumorCenter_CD3_block11_x3_y7_patient204_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14059.7, + "Centroid Y µm": 16884.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/204/TumorCenter_CD3_block11_x4_y7_patient204_1.json b/204/TumorCenter_CD3_block11_x4_y7_patient204_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b2a7813cf7644f126e4e41c9f00516bdd5265bc7 --- /dev/null +++ b/204/TumorCenter_CD3_block11_x4_y7_patient204_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16667.7, + "Centroid Y µm": 16966.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/204/TumorCenter_CD8_block11_x3_y7_patient204_0.json b/204/TumorCenter_CD8_block11_x3_y7_patient204_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bc2c17edcd2c7463a122c030bdc3f004c3a93c99 --- /dev/null +++ b/204/TumorCenter_CD8_block11_x3_y7_patient204_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11518.9, + "Centroid Y µm": 17190.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/204/TumorCenter_CD8_block11_x4_y7_patient204_1.json b/204/TumorCenter_CD8_block11_x4_y7_patient204_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b2645b9f707ba899733a48b0fc872df0b7ad332 --- /dev/null +++ b/204/TumorCenter_CD8_block11_x4_y7_patient204_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 17240.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/204/history_text.txt b/204/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d7775a53829c40c1e1f7059f8b421b16cc7ac438 --- /dev/null +++ b/204/history_text.txt @@ -0,0 +1 @@ +A carcinoma of the base of the tongue on the left side was found in the patient during a CUP panendoscopy. There was now an indication for laser resection. \ No newline at end of file diff --git a/204/icd_codes.txt b/204/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/204/ops_codes.txt b/204/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0109ff32fcf2862bafdec5f7cb7cac3de30212c3 --- /dev/null +++ b/204/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/204/patient_clinical_data.json b/204/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1cb0146db57ab89cb81299b9dcdecd411766a9a9 --- /dev/null +++ b/204/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": null, + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 30, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "+ chemotherapy (Abbruch!)", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/204/patient_pathological_data.json b/204/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7fedf4ed5a234116a3e2e2f3263bb8d3a13b9705 --- /dev/null +++ b/204/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "204", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/204/surgery_description.txt b/204/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ef7b4ee78375399a1060f408d48b9e1ee7574495 --- /dev/null +++ b/204/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy (Laser resection) diff --git a/204/surgery_report.txt b/204/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d49dae0500c5f5ff32dcc9b442289f1da2409f1 --- /dev/null +++ b/204/surgery_report.txt @@ -0,0 +1 @@ +After an introductory consultation with the anesthesia colleagues, the patient is first positioned. The base of the tongue is then positioned on the left side using the size B small bore tube. This shows a small circumscribed ulcer after monopolar coagulation from the previous operation. There are no microscopically suspicious tumor findings. A small induration is also palpable at depth. This area is now generously resected with the laser. The resection is performed up to the base of the vallecula. Then take marginal samples from the lateral, anterior, medial and basal settling areas. These are sent together with the resectate for frozen section diagnostics. The intraoperative diagnosis is as follows: Completely captured squamous cell carcinoma in fraction 1. However, metaplasia can still be seen in the anterior and medial settling area, which is why the pathology department recommends a subsequent resection. Careful resection of the medial and anterior settling area. So that a distance of 3-4 mm is created here again. Subsequently, careful hemostasis using monopolar coagulation. Then, when the wound is dry, after subtle bleeding control, the procedure is ended and all instruments are removed. After a final consultation with the anesthesia colleagues, the patient goes to the recovery room after extubation if the course of the anesthesia is normal. \ No newline at end of file diff --git a/205/InvasionFront_CD3_block15_x1_y6_patient205_0.json b/205/InvasionFront_CD3_block15_x1_y6_patient205_0.json new file mode 100644 index 0000000000000000000000000000000000000000..53183f94f19eec99e5ed4ba8e2ee1dcef07e73d8 --- /dev/null +++ b/205/InvasionFront_CD3_block15_x1_y6_patient205_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5896.9, + "Centroid Y µm": 25636.4, + "Num Detections": 18830, + "Num Negative": 15942, + "Num Positive": 2888, + "Positive %": 15.34, + "Num Positive per mm^2": 1190.6 + } +} \ No newline at end of file diff --git a/205/InvasionFront_CD3_block15_x2_y6_patient205_1.json b/205/InvasionFront_CD3_block15_x2_y6_patient205_1.json new file mode 100644 index 0000000000000000000000000000000000000000..947bcf37036a9c1be60409240348c154fbde33d5 --- /dev/null +++ b/205/InvasionFront_CD3_block15_x2_y6_patient205_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8570.5, + "Centroid Y µm": 25411.5, + "Num Detections": 20061, + "Num Negative": 17011, + "Num Positive": 3050, + "Positive %": 15.2, + "Num Positive per mm^2": 1228.9 + } +} \ No newline at end of file diff --git a/205/InvasionFront_CD8_block15_x1_y6_patient205_0.json b/205/InvasionFront_CD8_block15_x1_y6_patient205_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ebb1426f29647ea70e0a780efcb19e78b3dc9e27 --- /dev/null +++ b/205/InvasionFront_CD8_block15_x1_y6_patient205_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3904.3, + "Centroid Y µm": 15073.1, + "Num Detections": 16834, + "Num Negative": 14997, + "Num Positive": 1837, + "Positive %": 10.91, + "Num Positive per mm^2": 811.71 + } +} \ No newline at end of file diff --git a/205/InvasionFront_CD8_block15_x2_y6_patient205_1.json b/205/InvasionFront_CD8_block15_x2_y6_patient205_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c9ce5b2519a1b359bb10ec45cf514d5ce4c7733b --- /dev/null +++ b/205/InvasionFront_CD8_block15_x2_y6_patient205_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6566.8, + "Centroid Y µm": 14888.0, + "Num Detections": 18539, + "Num Negative": 15987, + "Num Positive": 2552, + "Positive %": 13.77, + "Num Positive per mm^2": 1062.9 + } +} \ No newline at end of file diff --git a/205/TumorCenter_CD3_block15_x1_y6_patient205_0.json b/205/TumorCenter_CD3_block15_x1_y6_patient205_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9ed8b0fb3ece6b3a4f6e5291544fb9699109365a --- /dev/null +++ b/205/TumorCenter_CD3_block15_x1_y6_patient205_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 18415.2, + "Num Detections": 20533, + "Num Negative": 17201, + "Num Positive": 3332, + "Positive %": 16.23, + "Num Positive per mm^2": 1351.7 + } +} \ No newline at end of file diff --git a/205/TumorCenter_CD3_block15_x2_y6_patient205_1.json b/205/TumorCenter_CD3_block15_x2_y6_patient205_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aee18db9215a8b5359e9ec37e273ee22312f47c8 --- /dev/null +++ b/205/TumorCenter_CD3_block15_x2_y6_patient205_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 18390.3, + "Num Detections": 19888, + "Num Negative": 15494, + "Num Positive": 4394, + "Positive %": 22.09, + "Num Positive per mm^2": 1765.6 + } +} \ No newline at end of file diff --git a/205/TumorCenter_CD8_block15_x1_y6_patient205_0.json b/205/TumorCenter_CD8_block15_x1_y6_patient205_0.json new file mode 100644 index 0000000000000000000000000000000000000000..15565f123c81ec4a422ecf13b68f03eb9719267e --- /dev/null +++ b/205/TumorCenter_CD8_block15_x1_y6_patient205_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6446.6, + "Centroid Y µm": 15067.0, + "Num Detections": 18611, + "Num Negative": 15466, + "Num Positive": 3145, + "Positive %": 16.9, + "Num Positive per mm^2": 1294.5 + } +} \ No newline at end of file diff --git a/205/TumorCenter_CD8_block15_x2_y6_patient205_1.json b/205/TumorCenter_CD8_block15_x2_y6_patient205_1.json new file mode 100644 index 0000000000000000000000000000000000000000..30586a3354385526a17fb71db165b523c71eaac1 --- /dev/null +++ b/205/TumorCenter_CD8_block15_x2_y6_patient205_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9020.2, + "Centroid Y µm": 15042.0, + "Num Detections": 19021, + "Num Negative": 14962, + "Num Positive": 4059, + "Positive %": 21.34, + "Num Positive per mm^2": 1650.2 + } +} \ No newline at end of file diff --git a/205/history_text.txt b/205/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..36e9a44dd7547569857d1b01f0ca74b8cd91bd5a --- /dev/null +++ b/205/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed oral cavity carcinoma on the lower surface of the tongue on the right, initial diagnosis <2014>. Clinical N0 neck status, without evidence of suspicious, enlarged lymph nodes. Clinical ulcer of at least 1 to 1.5 cm in diameter on the lower surface of the tongue on the right. A decision to resect the tumor is discussed and determined in our interdisciplinary tumor conference <2014 Now indication for the above-mentioned operation. \ No newline at end of file diff --git a/205/icd_codes.txt b/205/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8235f69822bdef09bcebc898840583a0443e6bb6 --- /dev/null +++ b/205/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Zungenunterfläche[C02.2 R] \ No newline at end of file diff --git a/205/ops_codes.txt b/205/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..04c75817f0a20ca74530a0c8d9da6a42c37ad291 --- /dev/null +++ b/205/ops_codes.txt @@ -0,0 +1 @@ +Exzision erkranktes Gewebe Zunge[5-250.2 ] Plastische Rekonstruktion Zunge[5-253.1 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/205/patient_clinical_data.json b/205/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..07b0fde8ddbae8646deba3ed5268dbb9f254231d --- /dev/null +++ b/205/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 37, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/205/patient_pathological_data.json b/205/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..75c4516534d01a11dab03586ffa72e9dbd0814ac --- /dev/null +++ b/205/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "205", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.6", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/205/surgery_description.txt b/205/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c67ba6f0d23102082084b48f7a1864a4cc274ae --- /dev/null +++ b/205/surgery_description.txt @@ -0,0 +1 @@ +Resection and Panendoscopy diff --git a/205/surgery_report.txt b/205/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..055dd88c4a7c51d4d7fcd99c28a499dc146f347e --- /dev/null +++ b/205/surgery_report.txt @@ -0,0 +1 @@ +First, the anesthesia colleague induces anesthesia and performs a rigid tracheobronchoscopy with 0° optics. The glottis, subglottis and trachea up to the entrance of the main bronchi show normal mucosal conditions, with no evidence of suspicious masses. After removal of the optics, intubation by the 1st surgeon. Flexible gastroesophagoscopy is then performed. The gastroscope is carefully advanced into the stomach under constant air insufflation. The stomach is then inspected and the mucosa is found to be normal in all areas, from the cardia to the pylorus. Then carefully withdraw the flexible gastroscope and inspect the esophagus from caudal to cranial, linea serrata and gastroesophageal junction 43 cm from the upper row of teeth. Caudal and middle part of the esophagus show slightly chronically altered mucosal conditions. Cranial ............................. of the esophagus are completely unremarkable. Then remove the flexible gastroscope and perform a direct pharyngoscopy using a size B small bore tube. After placing the mouth guard, carefully inspect the oral cavity and the oral vestibule. A relatively small, ulcer-shaped mass can be seen on the lower surface of the tongue paramedially on the right. On palpation, this grows endophytically into the body of the tongue. Next, inspection of the oropharynx. The soft and hard palate, palatal arches, posterior pharyngeal wall and base of the tongue are unremarkable. Switch to the size C small bore tube and inspect both piriform sinuses as well as the retrocricoidal area and supraglottis. Regular mucosal conditions here, no evidence of secondary malignancy. Removal of the small drainage tube without damaging the tooth and mouth structures. Placement of an oral retractor. The body and tip of the tongue are fixed with a suture and pulled out. The tumor is then exposed and the incision margins are marked at a distance of at least 1 to 1.2 cm from the tumor. After incision of the mucosa, careful suture marking was performed: 1st margin inferior, 3 o'clock long-long, 2nd margin lateral, short-long, 9 o'clock, 3rd margin medial, 9 o'clock, short-short. Then further dissection into the tongue musculature and maintaining the distance to the tumor of at least 1 cm. Careful dissection of the tongue muscles and careful hemostasis using ligatures and electrocoagulation. After removal of the tumor, a thin layer of muscle is removed caudally as a second sample. Both are sent for final histology. Careful hemostasis and securing of the Wharton's duct, which was not injured during the operation. Demonstration to and discussion of the further procedure. Joint decision on primary wound closure. The wound edges are carefully adapted and the wound is closed primarily. Handover of the patient to the anesthesia colleagues. Completion of the operation without complications. Conclusion: A T1 squamous cell carcinoma of the lower surface of the right tongue is resected and an inconspicuous panendoscopy is performed in the same session without complications. Intraoperatively endophytically growing ulcer, 1 to 1.3 cm in size, which grows at least 3 to 4 mm into the body of the tongue. Resection with a distance of at least 1 cm in all directions. The tissue was sent for final histological analysis. Further procedure after receipt of the final histology. If tumor infiltration is more than 8 mm, a selective right neck dissection should be performed. Please allow soft food from the 2nd postoperative day. Continue antibiotics with clindamycin for the next 3 days. \ No newline at end of file diff --git a/206/InvasionFront_CD3_block9_x5_y4_patient206_0.json b/206/InvasionFront_CD3_block9_x5_y4_patient206_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d337d2e25495554db9ad01e6b7fb652b2a7bbcbb --- /dev/null +++ b/206/InvasionFront_CD3_block9_x5_y4_patient206_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 10944.2, + "Num Detections": 10989, + "Num Negative": 10640, + "Num Positive": 349, + "Positive %": 3.176, + "Num Positive per mm^2": 232.58 + } +} \ No newline at end of file diff --git a/206/InvasionFront_CD3_block9_x6_y4_patient206_1.json b/206/InvasionFront_CD3_block9_x6_y4_patient206_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a52a4f70a1b5ab4eeb773837cb7683629bc8325e --- /dev/null +++ b/206/InvasionFront_CD3_block9_x6_y4_patient206_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21113.8, + "Centroid Y µm": 11319.0, + "Num Detections": 21240, + "Num Negative": 18449, + "Num Positive": 2791, + "Positive %": 13.14, + "Num Positive per mm^2": 1120.2 + } +} \ No newline at end of file diff --git a/206/InvasionFront_CD8_block9_x5_y4_patient206_0.json b/206/InvasionFront_CD8_block9_x5_y4_patient206_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f09ada876c9db343e63b54bad3391d56f6895f8 --- /dev/null +++ b/206/InvasionFront_CD8_block9_x5_y4_patient206_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18165.4, + "Centroid Y µm": 14692.2, + "Num Detections": 12565, + "Num Negative": 12042, + "Num Positive": 523, + "Positive %": 4.162, + "Num Positive per mm^2": 354.49 + } +} \ No newline at end of file diff --git a/206/InvasionFront_CD8_block9_x6_y4_patient206_1.json b/206/InvasionFront_CD8_block9_x6_y4_patient206_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b13c3228824304a1028cd7f9a656376e1652bcb8 --- /dev/null +++ b/206/InvasionFront_CD8_block9_x6_y4_patient206_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20664.1, + "Centroid Y µm": 14942.1, + "Num Detections": 23456, + "Num Negative": 21277, + "Num Positive": 2179, + "Positive %": 9.29, + "Num Positive per mm^2": 880.4 + } +} \ No newline at end of file diff --git a/206/TumorCenter_CD3_block9_x5_y4_patient206_0.json b/206/TumorCenter_CD3_block9_x5_y4_patient206_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7c8ed88eca05dfe7afd87e213c38dec42f19282c --- /dev/null +++ b/206/TumorCenter_CD3_block9_x5_y4_patient206_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16691.2, + "Centroid Y µm": 15891.6, + "Num Detections": 19956, + "Num Negative": 18321, + "Num Positive": 1635, + "Positive %": 8.193, + "Num Positive per mm^2": 697.59 + } +} \ No newline at end of file diff --git a/206/TumorCenter_CD3_block9_x6_y4_patient206_1.json b/206/TumorCenter_CD3_block9_x6_y4_patient206_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0d69741b046bb43dab0b377aca404c60487f429d --- /dev/null +++ b/206/TumorCenter_CD3_block9_x6_y4_patient206_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19239.8, + "Centroid Y µm": 16016.5, + "Num Detections": 22339, + "Num Negative": 19508, + "Num Positive": 2831, + "Positive %": 12.67, + "Num Positive per mm^2": 1081.0 + } +} \ No newline at end of file diff --git a/206/TumorCenter_CD8_block9_x5_y4_patient206_0.json b/206/TumorCenter_CD8_block9_x5_y4_patient206_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a45a2bfb99af7c13a66f609ebff9684193e9ff6 --- /dev/null +++ b/206/TumorCenter_CD8_block9_x5_y4_patient206_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 10644.4, + "Num Detections": 16730, + "Num Negative": 15724, + "Num Positive": 1006, + "Positive %": 6.013, + "Num Positive per mm^2": 496.64 + } +} \ No newline at end of file diff --git a/206/TumorCenter_CD8_block9_x6_y4_patient206_1.json b/206/TumorCenter_CD8_block9_x6_y4_patient206_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9ab9eba2f1f89c4909ca15d6347945225993080d --- /dev/null +++ b/206/TumorCenter_CD8_block9_x6_y4_patient206_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 10494.4, + "Num Detections": 21067, + "Num Negative": 19402, + "Num Positive": 1665, + "Positive %": 7.903, + "Num Positive per mm^2": 667.28 + } +} \ No newline at end of file diff --git a/206/history_text.txt b/206/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/206/icd_codes.txt b/206/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7c4b0e37c6148a83f8c22cde2a96190aa8c85b57 --- /dev/null +++ b/206/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] Neubildung bösartig sekundär und onA Lymphknoten Kopf Gesicht Hals[C77.0 B] \ No newline at end of file diff --git a/206/ops_codes.txt b/206/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85ed1d7d5c76e1d3b18ebbbd1b866f4b3acdca50 --- /dev/null +++ b/206/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale Neck dissection in 4 Regionen[5-403.10 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.x1 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/206/patient_clinical_data.json b/206/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..272d822f03fffec775592431bbaff6b8c58bb6d8 --- /dev/null +++ b/206/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/206/patient_pathological_data.json b/206/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3f0030d57127a7f4b2dd0473e9e4bd65a1c96f45 --- /dev/null +++ b/206/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "206", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/206/surgery_description.txt b/206/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..73fb899fd7d87d69841f101cfcb2eb8612bbbcd0 --- /dev/null +++ b/206/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, PEG placement, Tracheostomy diff --git a/206/surgery_report.txt b/206/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..20e6832c9cab800bdc02680b2230ba06482a9f07 --- /dev/null +++ b/206/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesiologist. Intubation transnasally by the anesthetist. Entry with the flexible gastroesophagoscope and endoscopy into the stomach. Inconspicuous conditions on all sides. If diaphanoscopy is good, perform a PEG insertion using the thread pull-through method. Enter with the Kleinsasser tube and inspect the tumor region. There is an exophytic mass in the area of the left piriform sinus on the lateral and anterior wall. The medial and posterior border of the left piriform sinus is not covered by the tumor. The postcricoid and arytenoid region of the larynx is free on both sides. The vocal fold level and the pocket fold level as well as the epiglottis are also not affected by the tumor. It was therefore decided not to perform a complete laryngectomy. Now injection of xylocaine-adrenaline mixture in the throat area. Sterile washing and draping. Creation of an apron flap in the usual manner. Start with the neck dissection on the left side. Exposure of the sternocleidomastoid muscle, the omohyoid muscle and the submandibular gland. It becomes clear that the sternocleidomastoid muscle and the internal jugular vein cannot be preserved on this side, so switch to the right side. Carry out the neck dissection on the right side to ensure that the internal jugular vein can be preserved here. Expose the sternocleidomastoid muscle, the omohyoid muscle, the digastric muscle and the submandibular gland. Exposure of the cervical vascular sheath. Free preparation of the internal jugular vein. The entire length of the internal jugular vein can be preserved, including the outlet of the facial vein and the facial vein itself. Exposure of the accessorius nerve and the superior thyroid. Release of the medial neck block and then release of the neck block II a to V a while sparing the plexus branches. This is successful without any problems. Then transfer to the opposite side and release of the medial neck block with detachment of a 5 x 3 cm metastasis in level II a. This is very difficult as the mass cannot be detached from the jugular vein. This is detached in the area at the border to level III. If the facial vein is very deep, the facial vein itself may remain intact. The sternocleidomastoid muscle must be partially resected and the accessory nerve must also be resected, as it runs directly into the tumor. The metastasis is now successively detached from the internal and external carotid artery. This can be done bluntly with the stalk to ensure that there is no infiltration of these vessels. Finally, the metastasis must also be bluntly detached from the vagus nerve and also from the hypoglossal nerve. Dissection in this area is generally very difficult. Ultimately, the metastasis is successfully detached from the nerves and vessels mentioned above and from the base of the skull. The remaining neck regions are then cleared out while sparing the remaining plexus branches. Entering the pharynx below the hyoid bone from the right side. Inspection of the tumor. This is localized as described above for pharyngoscopy. It is completely incised with a safety margin of 1.5 cm and is marked with a suture for the frozen section. The frozen section shows a complete R0 situation without carcinoma in situ, invasive carcinoma or dysplasia in the marginal area. As there is ultimately sufficient mucosa in the pharyngeal area, the decision is made to perform primary wound closure. This is usually carried out in two layers. As the mucosa is very thin in places and is somewhat under tension in some areas, the thyroid gland and the infrahyal muscles are stitched over the suture area. Finally, two Redon drains are inserted and a two-layer wound closure is performed. A tracheotomy was performed between the 1st and 2nd tracheal cartilage before the tumor resection. Creation of a visor tracheotomy without Björk flap. Epithelialization of the tracheal margins with the skin. Insertion of an 8 mm tracheal cannula. The patient is admitted to the intensive care unit in an awake state and should receive 3 days of intravenous antibiotics with Unacid and on the 10th postoperative day an X-ray vomit swallow, then if there is no fistula, removal of the nasogastric tube and implementation of the diet. Postoperative presentation of the patient at the tumor conference to plan adjuvant radiochemotherapy. \ No newline at end of file diff --git a/207/InvasionFront_CD3_block8_x3_y3_patient207_0.json b/207/InvasionFront_CD3_block8_x3_y3_patient207_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42d8a835a27bdff124bbead66d31c0170c09dddd --- /dev/null +++ b/207/InvasionFront_CD3_block8_x3_y3_patient207_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11094.1, + "Centroid Y µm": 17890.5, + "Num Detections": 4575, + "Num Negative": 4280, + "Num Positive": 295, + "Positive %": 6.448, + "Num Positive per mm^2": 527.44 + } +} \ No newline at end of file diff --git a/207/InvasionFront_CD3_block8_x4_y3_patient207_1.json b/207/InvasionFront_CD3_block8_x4_y3_patient207_1.json new file mode 100644 index 0000000000000000000000000000000000000000..26046e56750799d9286d19861fa7ec8b76d31e35 --- /dev/null +++ b/207/InvasionFront_CD3_block8_x4_y3_patient207_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 17690.6, + "Num Detections": 18008, + "Num Negative": 17288, + "Num Positive": 720, + "Positive %": 3.998, + "Num Positive per mm^2": 317.72 + } +} \ No newline at end of file diff --git a/207/InvasionFront_CD8_block8_x3_y3_patient207_0.json b/207/InvasionFront_CD8_block8_x3_y3_patient207_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9a84cecab6008287b235da76001df5089747394d --- /dev/null +++ b/207/InvasionFront_CD8_block8_x3_y3_patient207_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12193.5, + "Centroid Y µm": 7670.9, + "Num Detections": 4827, + "Num Negative": 4671, + "Num Positive": 156, + "Positive %": 3.232, + "Num Positive per mm^2": 255.48 + } +} \ No newline at end of file diff --git a/207/InvasionFront_CD8_block8_x4_y3_patient207_1.json b/207/InvasionFront_CD8_block8_x4_y3_patient207_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9de5243161bfec40ae8874fc3d752d5c7ab86c15 --- /dev/null +++ b/207/InvasionFront_CD8_block8_x4_y3_patient207_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14692.2, + "Centroid Y µm": 7770.9, + "Num Detections": 19542, + "Num Negative": 18439, + "Num Positive": 1103, + "Positive %": 5.644, + "Num Positive per mm^2": 469.37 + } +} \ No newline at end of file diff --git a/207/TumorCenter_CD3_block8_x3_y3_patient207_0.json b/207/TumorCenter_CD3_block8_x3_y3_patient207_0.json new file mode 100644 index 0000000000000000000000000000000000000000..94fab6de3bcbe26e9ad062ff626416032338bcd5 --- /dev/null +++ b/207/TumorCenter_CD3_block8_x3_y3_patient207_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10856.8, + "Centroid Y µm": 8657.9, + "Num Detections": 14455, + "Num Negative": 14017, + "Num Positive": 438, + "Positive %": 3.03, + "Num Positive per mm^2": 250.59 + } +} \ No newline at end of file diff --git a/207/TumorCenter_CD3_block8_x4_y3_patient207_1.json b/207/TumorCenter_CD3_block8_x4_y3_patient207_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9383fbb5f64ebfa3689958e0ecd4847b1ee470c1 --- /dev/null +++ b/207/TumorCenter_CD3_block8_x4_y3_patient207_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 8308.1, + "Num Detections": 8731, + "Num Negative": 8408, + "Num Positive": 323, + "Positive %": 3.699, + "Num Positive per mm^2": 335.22 + } +} \ No newline at end of file diff --git a/207/TumorCenter_CD8_block8_x3_y3_patient207_0.json b/207/TumorCenter_CD8_block8_x3_y3_patient207_0.json new file mode 100644 index 0000000000000000000000000000000000000000..15893ebd95ccca8c6ad1c0eea4e7cbf6b2d807ea --- /dev/null +++ b/207/TumorCenter_CD8_block8_x3_y3_patient207_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 8095.7, + "Num Detections": 16128, + "Num Negative": 16029, + "Num Positive": 99, + "Positive %": 0.6138, + "Num Positive per mm^2": 57.64 + } +} \ No newline at end of file diff --git a/207/TumorCenter_CD8_block8_x4_y3_patient207_1.json b/207/TumorCenter_CD8_block8_x4_y3_patient207_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1930f9a893e9028de9a3c848ddee46d73d9c6f68 --- /dev/null +++ b/207/TumorCenter_CD8_block8_x4_y3_patient207_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 7870.8, + "Num Detections": 8991, + "Num Negative": 8845, + "Num Positive": 146, + "Positive %": 1.624, + "Num Positive per mm^2": 164.85 + } +} \ No newline at end of file diff --git a/207/history_text.txt b/207/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc08d30801b495f9a8a04cd9b39e9a33d172f1d0 --- /dev/null +++ b/207/history_text.txt @@ -0,0 +1 @@ +The patient has been suffering from dysphagia and intermittent pain for 6 months. An external histology was performed on the anterior palatal arch, which revealed squamous cell carcinoma. \ No newline at end of file diff --git a/207/icd_codes.txt b/207/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e3dca6ce6d546b02f87f7a4fe8fab89f934a14ea --- /dev/null +++ b/207/icd_codes.txt @@ -0,0 +1 @@ +Rachenmandelkarzinom[C11.1 ] \ No newline at end of file diff --git a/207/ops_codes.txt b/207/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..841793a8aa397bfff8ad16f9f8fe804b8e26e14d --- /dev/null +++ b/207/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Diagnostische Gastroskopie[1-631 ] Direkte Hypopharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Probeexzision Alveolarkamm Kiefer[1-545.1 ] \ No newline at end of file diff --git a/207/patient_clinical_data.json b/207/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..76d9efbd9683096bac4457068f212e2896b5fb0a --- /dev/null +++ b/207/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/207/patient_pathological_data.json b/207/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..34120dedcfaaf7ac81c4ec4a80149640f9a6992c --- /dev/null +++ b/207/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "207", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/207/surgery_description.txt b/207/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8526c25405ac30b4d446306fa371bcfa2b5937f4 --- /dev/null +++ b/207/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Panendoscopy, PE (Proximal esophagus) in the upper and lower jaw diff --git a/207/surgery_report.txt b/207/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..759261016e241c2686cd16d3d186cada9086e0e1 --- /dev/null +++ b/207/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia by anesthesia, then entering with the 0° optics and inspection of the trachea. This can be seen freely up to the carina and is non-irritating. Then intubation by the surgeon with Cormack I. The flexible esophagoscope is then inserted and the esophagus is visualized through to the stomach, where the mucosa is free of irritation on all sides. Retract the esophagoscope and enter with the small bore tube. Inspection of the oropharynx. This shows the previously described mass at the upper left tonsil pole. Mirroring forward to the posterior pharyngeal wall and hypopharynx. Inconspicuous on all sides. Inspection of the piriform sinus and the entrance to the esophagus as well as the postcricoid region and the arytenoid region. No tumorous masses. Adjustment of the glottic plane and inspection of the vocal folds and pocket folds including the anterior commissure. No abnormalities here. Insertion of the tonsil stop and inspection of the left tonsil lobe. A rough mass can be seen at the upper tonsil pole with transition to the anterior palatal arch. The mucosa is incised with a safety margin using the monopolar needle. Then further preparation with scissors and bipolar forceps. Removal of the tonsil including the mass with a safety margin. The tonsil is thread-marked for histology. Then removal of marginal samples, thread-marked. 1st marginal sample anterior palatal arch, suture marking near the uvula, 2nd marginal sample oropharyngeal side wall, suture marking base of tongue, 3rd marginal sample base of tongue, without suture marking, 4th marginal sample posterior palatal arch, also suture marking base of tongue. Then inspection of the alveolar ridges. A suspicious change in the mucosa in region III/VII to VIII can be seen on the alveolar ridge on the lower jaw. This is biopsied. Then inspection of the alveolar ridge on the left side of the maxilla. There is actually no suspicious mass here, but as a contrast agent uptake was described in regions II/IV to II/VI on the CT, this region was also biopsied. Hemostasis by insertion of hydrogen swabs and bipolar coagulation. The operation was completed with dry blood, without complications. Conclusion: cT1 cN0 tonsillar carcinoma on the left. Neck dissection on the left side should be planned, if necessary with resection if the marginal samples are not healthy. If the samples from the alveolar ridges also show carcinoma or carcinoma in situ, the patient should be presented to the maxillofacial clinic. \ No newline at end of file diff --git a/208/InvasionFront_CD3_block6_x1_y11_patient208_0.json b/208/InvasionFront_CD3_block6_x1_y11_patient208_0.json new file mode 100644 index 0000000000000000000000000000000000000000..63ac95427a307da977ffafdfdfd68a373d660854 --- /dev/null +++ b/208/InvasionFront_CD3_block6_x1_y11_patient208_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3698.0, + "Centroid Y µm": 28085.1, + "Num Detections": 16660, + "Num Negative": 15683, + "Num Positive": 977, + "Positive %": 5.864, + "Num Positive per mm^2": 431.6 + } +} \ No newline at end of file diff --git a/208/InvasionFront_CD3_block6_x2_y11_patient208_1.json b/208/InvasionFront_CD3_block6_x2_y11_patient208_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3ee1181037f632aca20606c4638a4a3622187e7e --- /dev/null +++ b/208/InvasionFront_CD3_block6_x2_y11_patient208_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 28235.1, + "Num Detections": 15987, + "Num Negative": 15599, + "Num Positive": 388, + "Positive %": 2.427, + "Num Positive per mm^2": 183.57 + } +} \ No newline at end of file diff --git a/208/InvasionFront_CD8_block6_x1_y9_patient208_0.json b/208/InvasionFront_CD8_block6_x1_y9_patient208_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f44c1a0aac2b191d31b45995ccee9f3fcf16f47 --- /dev/null +++ b/208/InvasionFront_CD8_block6_x1_y9_patient208_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4122.8, + "Centroid Y µm": 22313.2, + "Num Detections": 23763, + "Num Negative": 16012, + "Num Positive": 7751, + "Positive %": 32.62, + "Num Positive per mm^2": 2817.4 + } +} \ No newline at end of file diff --git a/208/InvasionFront_CD8_block6_x2_y9_patient208_1.json b/208/InvasionFront_CD8_block6_x2_y9_patient208_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ad24ab07c37e0d94dfec51f09ff11aaa53bd44b0 --- /dev/null +++ b/208/InvasionFront_CD8_block6_x2_y9_patient208_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6896.3, + "Centroid Y µm": 22413.1, + "Num Detections": 30236, + "Num Negative": 23257, + "Num Positive": 6979, + "Positive %": 23.08, + "Num Positive per mm^2": 2245.6 + } +} \ No newline at end of file diff --git a/208/TumorCenter_CD3_block6_x1_y9_patient208_0.json b/208/TumorCenter_CD3_block6_x1_y9_patient208_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e75c3e11d6da4f1b3640a372ef5d178a5338fdd1 --- /dev/null +++ b/208/TumorCenter_CD3_block6_x1_y9_patient208_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 23212.7, + "Num Detections": 24650, + "Num Negative": 16514, + "Num Positive": 8136, + "Positive %": 33.01, + "Num Positive per mm^2": 2790.8 + } +} \ No newline at end of file diff --git a/208/TumorCenter_CD3_block6_x2_y9_patient208_1.json b/208/TumorCenter_CD3_block6_x2_y9_patient208_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a38c4fd42babb8c8c54a10cd3642702c3b0dcb55 --- /dev/null +++ b/208/TumorCenter_CD3_block6_x2_y9_patient208_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 23137.7, + "Num Detections": 24284, + "Num Negative": 17829, + "Num Positive": 6455, + "Positive %": 26.58, + "Num Positive per mm^2": 2328.6 + } +} \ No newline at end of file diff --git a/208/TumorCenter_CD8_block6_x1_y9_patient208_0.json b/208/TumorCenter_CD8_block6_x1_y9_patient208_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3e771ba88a2cbb7049195dd40dfde88ef7c3032f --- /dev/null +++ b/208/TumorCenter_CD8_block6_x1_y9_patient208_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 23462.6, + "Num Detections": 27331, + "Num Negative": 22228, + "Num Positive": 5103, + "Positive %": 18.67, + "Num Positive per mm^2": 1705.9 + } +} \ No newline at end of file diff --git a/208/TumorCenter_CD8_block6_x2_y9_patient208_1.json b/208/TumorCenter_CD8_block6_x2_y9_patient208_1.json new file mode 100644 index 0000000000000000000000000000000000000000..313ff4e3aa69a7f5f13fcda9ef372592a84d509e --- /dev/null +++ b/208/TumorCenter_CD8_block6_x2_y9_patient208_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 23512.6, + "Num Detections": 23511, + "Num Negative": 20472, + "Num Positive": 3039, + "Positive %": 12.93, + "Num Positive per mm^2": 1207.0 + } +} \ No newline at end of file diff --git a/208/history_text.txt b/208/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/208/icd_codes.txt b/208/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f101f4a17d935e9a8a122007a293961ee773536b --- /dev/null +++ b/208/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/208/ops_codes.txt b/208/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..809920bb2bba32c31d27657995cf268f536f3af3 --- /dev/null +++ b/208/ops_codes.txt @@ -0,0 +1 @@ +Direkte Hypopharyngoskopie[1-611.0 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Direkte diagnostische Pharyngoskopie[1-611.0 ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/208/patient_clinical_data.json b/208/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d4b2bbacb520a8cec2b2e96e6839c49b8ba0d60a --- /dev/null +++ b/208/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/208/patient_pathological_data.json b/208/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d4075472488a0c39ee11976343731adf0dd640e5 --- /dev/null +++ b/208/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "208", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 38, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/208/surgery_description.txt b/208/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a82a1d8dd7b27d3accda095758052c92775f045 --- /dev/null +++ b/208/surgery_description.txt @@ -0,0 +1 @@ +Resection, Bilateral neck dissection, Tracheotomy diff --git a/208/surgery_report.txt b/208/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..27807915c1ada62b328adbdfd55c6578bcd5a74d --- /dev/null +++ b/208/surgery_report.txt @@ -0,0 +1 @@ +Transferring the patient to the operating theater and positioning the patient. Introductory consultation with the anesthesia department and team time-out. Problem-free intubation. First attempt at PEG placement. There is no clear diaphanoscopy here, so the PEG is not inserted. Marking of the landmarks and skin incision, dissection through the subcutaneous fatty tissue. Exposure of the prelaryngeal musculature, strict dissection along the alba line into the deep and lateral spread of the prelaryngeal musculature. Exposure of the thyroid gland. Coagulation below the cricoid cartilage and transection of the thyroid gland using 2 Pean clamps and a bypass as well as bipolar coagulation. Exposure of the anterior wall of the trachea and exposing it. Insertion between the 2nd and 3rd tracheal cartilage in the sense of a visor tracheotomy. The brachiocephalic trunk can be seen pulsating in depth. However, a layer of tissue and fat can still be identified over the brachiocephalic trunk. Incision of the tracheostoma in the usual manner. Now sterile abjoration and covering. Exposure of the tumor in the hypopharyngeal region with the spreading laryngoscope. The tumor is stalked on the medial pharyngeal wall and on the anterior piriform sinus wall and extends laterally to the arytenoid cartilage. The posterior pharyngeal wall and also the lateral pharyngeal walls are free. The tumor is now successively removed using a CO2 laser with a safety margin of at least 1 cm in all directions. The arytenoid cartilage remains and is covered with a layer of mucous membrane. No pharyngeal fatty tissue is visible. After removal of the tumor and hemostasis using bipolar coagulation, suture marking of the specimen and submission for frozen section, this shows an R0 resection, for this reason repositioning for neck dissection on both sides, starting on the right side. Marking of the landmarks. Skin incision and dissection through the subcutaneous fatty tissue. Exposure of the anterior border of the sternocleidomastoid muscle and exposure of the accessorius nerve. Dissection along the omohyoid muscle in a cranial direction and exposure of the submandibular gland. Exposure of the posterior venter of the digasatric muscle and preparation in the direction of level IIb. Successive free dissection of the venter posterior digastric muscle and caudal exposure of the neck preparation. Free dissection of the internal jugular vein and successive dissection of the lateral neck preparation. N. accessorius and the plexus ........................................ can be spared. Identification of the vagus nerve, which can also be spared. Dissection of the jugulofacial angle and visualization of the hypoglossal nerve, which can also be spared. Now successive removal of the medial neck preparation. All in all, inconspicuous neck side with removal of the lymph nodes from level II to V. No indication of increased bleeding. Bleeding. Application of a redon drainage and two-layer wound closure. Transfer to the left side. Here too, skin incision and dissection through the subcutaneous fatty tissue. Exposure of the anterior border of the sternocleidomastoid muscle. This shows a large metastasis of 6.5 cm in level IIb which extends under the posterior digastric muscle and up to the mastoid. For this reason, first dissect the omohyoid muscle and expose the submandibular gland. Pull up the submandibular gland and expose the posterior venter of the digastric muscle. Dissection posteriorly in the direction of level IIb. Exposure of the internal jugular vein in the caudal area and free dissection of this. Likewise exposure of the facial vein and free dissection of this. Now successive detachment of the metastasis from level IIb and the internal jugular vein. This is achieved successively using bipolar coagulation and scissors. The metastasis can be sharply detached from the posterior digastric vein. The vein, the accessorius nerve and the sternocleidomastoid muscle can be preserved and are not infiltrated. After removal of the large metastasis, successive evacuation of the lateral neck preparation while sparing the brachial plexus. Identification of the hypoglossal nerve in the jugulo-facial angle and protection of the vagus nerve, successive dissection of the medial neck preparation. Hemostasis. There is no evidence of increased bleeding. Irrigation of the situs. Neck dissection from level II to level V was also performed here. If conditions were normal, insertion of a Redon drain and two-layer wound closure. Re-intubation blocked on an 8-gauge Rüsch cannula. There is no evidence of increased bleeding on all sides. Final consultation with the anesthesia department. The PEG insertion should be planned with the colleagues at . \ No newline at end of file diff --git a/209/InvasionFront_CD3_block8_x1_y9_patient209_0.json b/209/InvasionFront_CD3_block8_x1_y9_patient209_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2aa70823961d95a5e3d48c6b4d9bbb29e3fec746 --- /dev/null +++ b/209/InvasionFront_CD3_block8_x1_y9_patient209_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 33157.4, + "Num Detections": 20017, + "Num Negative": 19255, + "Num Positive": 762, + "Positive %": 3.807, + "Num Positive per mm^2": 293.5 + } +} \ No newline at end of file diff --git a/209/InvasionFront_CD3_block8_x2_y9_patient209_1.json b/209/InvasionFront_CD3_block8_x2_y9_patient209_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4e25f2ee5313fab9cdbafa046a1a852c2589195d --- /dev/null +++ b/209/InvasionFront_CD3_block8_x2_y9_patient209_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 33082.5, + "Num Detections": 28282, + "Num Negative": 26419, + "Num Positive": 1863, + "Positive %": 6.587, + "Num Positive per mm^2": 701.49 + } +} \ No newline at end of file diff --git a/209/InvasionFront_CD8_block8_x1_y9_patient209_0.json b/209/InvasionFront_CD8_block8_x1_y9_patient209_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f61b1ee5201d73d4f24a71a3723138176075e80b --- /dev/null +++ b/209/InvasionFront_CD8_block8_x1_y9_patient209_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3498.1, + "Centroid Y µm": 22513.1, + "Num Detections": 22558, + "Num Negative": 19950, + "Num Positive": 2608, + "Positive %": 11.56, + "Num Positive per mm^2": 1008.2 + } +} \ No newline at end of file diff --git a/209/InvasionFront_CD8_block8_x2_y9_patient209_1.json b/209/InvasionFront_CD8_block8_x2_y9_patient209_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7242244434114841e66ca1094b8a279dcaaec4d9 --- /dev/null +++ b/209/InvasionFront_CD8_block8_x2_y9_patient209_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 22762.9, + "Num Detections": 26666, + "Num Negative": 24045, + "Num Positive": 2621, + "Positive %": 9.829, + "Num Positive per mm^2": 983.95 + } +} \ No newline at end of file diff --git a/209/TumorCenter_CD3_block8_x1_y9_patient209_0.json b/209/TumorCenter_CD3_block8_x1_y9_patient209_0.json new file mode 100644 index 0000000000000000000000000000000000000000..96a7fbef8ca1fce3524bb3cd3b2777dbcdf11795 --- /dev/null +++ b/209/TumorCenter_CD3_block8_x1_y9_patient209_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5472.1, + "Centroid Y µm": 24237.2, + "Num Detections": 22620, + "Num Negative": 19384, + "Num Positive": 3236, + "Positive %": 14.31, + "Num Positive per mm^2": 1292.5 + } +} \ No newline at end of file diff --git a/209/TumorCenter_CD3_block8_x2_y9_patient209_1.json b/209/TumorCenter_CD3_block8_x2_y9_patient209_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5df7b162cb0fd35f8f7cd98ebdb672a85b01a621 --- /dev/null +++ b/209/TumorCenter_CD3_block8_x2_y9_patient209_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8045.7, + "Centroid Y µm": 24012.3, + "Num Detections": 27739, + "Num Negative": 26373, + "Num Positive": 1366, + "Positive %": 4.924, + "Num Positive per mm^2": 507.37 + } +} \ No newline at end of file diff --git a/209/TumorCenter_CD8_block8_x1_y9_patient209_0.json b/209/TumorCenter_CD8_block8_x1_y9_patient209_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9cdb3a8d21b611c65b6db3e5c002364c366f8f2f --- /dev/null +++ b/209/TumorCenter_CD8_block8_x1_y9_patient209_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4747.5, + "Centroid Y µm": 23437.6, + "Num Detections": 22727, + "Num Negative": 19969, + "Num Positive": 2758, + "Positive %": 12.14, + "Num Positive per mm^2": 1112.7 + } +} \ No newline at end of file diff --git a/209/TumorCenter_CD8_block8_x2_y9_patient209_1.json b/209/TumorCenter_CD8_block8_x2_y9_patient209_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c05438ba2150216d94d9eec7230ae11fe4fbf1e --- /dev/null +++ b/209/TumorCenter_CD8_block8_x2_y9_patient209_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7446.1, + "Centroid Y µm": 23262.7, + "Num Detections": 29027, + "Num Negative": 27380, + "Num Positive": 1647, + "Positive %": 5.674, + "Num Positive per mm^2": 617.85 + } +} \ No newline at end of file diff --git a/209/history_text.txt b/209/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1da753a39ad6cf3852cb3ee5d19a4e4b07462fb4 --- /dev/null +++ b/209/history_text.txt @@ -0,0 +1 @@ +The patient has had an indolent swelling of the right cervical lymph node for several weeks. Sonographically suspicious change with possible cN2a neck status, DD lymphoma. Inspection revealed a clear asymmetry of the tonsils, so that there is now an indication to confirm the diagnosis. \ No newline at end of file diff --git a/209/icd_codes.txt b/209/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/209/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/209/ops_codes.txt b/209/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc6e8b8cd448d1efd37d94462926642d90fe910f --- /dev/null +++ b/209/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Tonsillektomie radikal transoral[5-281.2 ] \ No newline at end of file diff --git a/209/patient_clinical_data.json b/209/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6bf2b322376e441fbc95084752438331453d88b3 --- /dev/null +++ b/209/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/209/patient_pathological_data.json b/209/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4e9a27b882deadf22b7710cabfe88107d9ecb76d --- /dev/null +++ b/209/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "209", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/209/surgery_description.txt b/209/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e98cc65c022ec00868f70bedf68bbc13e6f7a373 --- /dev/null +++ b/209/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Panendoscopy diff --git a/209/surgery_report.txt b/209/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..418efd78d9b753fb617f3768532018bc597c4e2c --- /dev/null +++ b/209/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, a rigid tracheoscopy is performed under laryngoscopic control, revealing the endolarynx, the subglottic region and the trachea up to the carina, intubation by the surgeon without any problems. Subsequent positioning. First perform flexible esophagogastroscopy. For this, enter with the gastroscope under laryngoscopic control. Easy visualization of the stomach. The stomach is inconspicuous and clear, as is the oesophagus on reflection. Now enter with the Kleinsasser tube under dental protection after inspection of the inconspicuous oral vestibule. Inspection of the oral cavity, including the floor of the mouth, tongue and soft palate. First inspection of the endolarynx. As described above, this is completely normal and clear, as is the hypopharynx, which can be easily adjusted up to the esophageal inlet and the tips of the piriform sinus. Inspection of the oropharynx. A clear tonsillar hyperplasia on the left with intratonsillar thickening and coarse changes is clearly suspicious, but based on the palpation findings it is more likely to be an intratonsillar tumor than a lymphoma. The rest of the oropharynx is unremarkable and free except for a left-sided circumscribed vallecula cyst. Demonstration of findings also on . Subsequently, in case of cT2 tonsillar carcinoma, perform a right tumor tonsillectomy. For this purpose, incision at the anterior palatal arch with subtotal removal of the anterior palatal arch. Resection of the tonsil, leaving a muscle cuff on the tonsil. Mucosal resection distance of a good 1 cm on all sides. Removal at the transition to the tongue base tonsil, also including a muscle cuff in the area of the posterior palatal arch. Extubation of the tumor which is macroscopically resected in sano with a sufficient safety margin on all sides in the mucosal area and also in the soft tissue area. The specimen is thread-marked and sent for urgent histology. Careful hemostasis. Multiple checks and completion of the procedure without any indication of complications. Conclusion: Intraoperative high-grade suspicion of cT2 cN2a tonsillar carcinoma on the right. If this is confirmed histologically, neck dissection of the right side should be planned for a second time, as well as a CT thorax to complete the staging. If an R-1 situation persists despite further macroscopic in sano resection, a subsequent resection in the basal area with delayed neck dissection must be planned. Alternatively, neck dissection with the option of flap coverage. \ No newline at end of file diff --git a/210/InvasionFront_CD3_block20_x1_y11_patient210_0.json b/210/InvasionFront_CD3_block20_x1_y11_patient210_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a2ed5ea98b57be1df63bc1079e37f4175d8c5438 --- /dev/null +++ b/210/InvasionFront_CD3_block20_x1_y11_patient210_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 26261.1, + "Num Detections": 18507, + "Num Negative": 18042, + "Num Positive": 465, + "Positive %": 2.513, + "Num Positive per mm^2": 234.74 + } +} \ No newline at end of file diff --git a/210/InvasionFront_CD3_block20_x2_y11_patient210_1.json b/210/InvasionFront_CD3_block20_x2_y11_patient210_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ff75a8c28d23aff0f6691ca77996bce9602a548c --- /dev/null +++ b/210/InvasionFront_CD3_block20_x2_y11_patient210_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 26560.9, + "Num Detections": 25630, + "Num Negative": 23225, + "Num Positive": 2405, + "Positive %": 9.384, + "Num Positive per mm^2": 924.31 + } +} \ No newline at end of file diff --git a/210/InvasionFront_CD8_block20_x1_y10_patient210_0.json b/210/InvasionFront_CD8_block20_x1_y10_patient210_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5380692456a0a60dcef4e15d8312b01c9ba7f1f4 --- /dev/null +++ b/210/InvasionFront_CD8_block20_x1_y10_patient210_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5010.4, + "Centroid Y µm": 25253.1, + "Num Detections": 3297, + "Num Negative": 3154, + "Num Positive": 143, + "Positive %": 4.337, + "Num Positive per mm^2": 355.45 + } +} \ No newline at end of file diff --git a/210/InvasionFront_CD8_block20_x2_y10_patient210_1.json b/210/InvasionFront_CD8_block20_x2_y10_patient210_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dabe4e0f2ed94d8f31296ffee9d3db713a7ed512 --- /dev/null +++ b/210/InvasionFront_CD8_block20_x2_y10_patient210_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7300.9, + "Centroid Y µm": 25194.5, + "Num Detections": 11314, + "Num Negative": 10848, + "Num Positive": 466, + "Positive %": 4.119, + "Num Positive per mm^2": 340.13 + } +} \ No newline at end of file diff --git a/210/TumorCenter_CD3_block20_x1_y10_patient210_0.json b/210/TumorCenter_CD3_block20_x1_y10_patient210_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3f76555c49dd9a64d128a95ccda124df8c25cb9f --- /dev/null +++ b/210/TumorCenter_CD3_block20_x1_y10_patient210_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3722.4, + "Centroid Y µm": 24173.1, + "Num Detections": 6273, + "Num Negative": 4992, + "Num Positive": 1281, + "Positive %": 20.42, + "Num Positive per mm^2": 533.23 + } +} \ No newline at end of file diff --git a/210/TumorCenter_CD3_block20_x2_y10_patient210_1.json b/210/TumorCenter_CD3_block20_x2_y10_patient210_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b8151a83931e5cbc7bf50f3262055fcb1391282 --- /dev/null +++ b/210/TumorCenter_CD3_block20_x2_y10_patient210_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6245.0, + "Centroid Y µm": 24078.2, + "Num Detections": 3843, + "Num Negative": 3100, + "Num Positive": 743, + "Positive %": 19.33, + "Num Positive per mm^2": 585.23 + } +} \ No newline at end of file diff --git a/210/TumorCenter_CD8_block20_x1_y10_patient210_0.json b/210/TumorCenter_CD8_block20_x1_y10_patient210_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a96620973bea917efacc92acdb5cb7a2c78052c0 --- /dev/null +++ b/210/TumorCenter_CD8_block20_x1_y10_patient210_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 25536.5, + "Num Detections": 20485, + "Num Negative": 18736, + "Num Positive": 1749, + "Positive %": 8.538, + "Num Positive per mm^2": 684.07 + } +} \ No newline at end of file diff --git a/210/TumorCenter_CD8_block20_x2_y10_patient210_1.json b/210/TumorCenter_CD8_block20_x2_y10_patient210_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d4795605c0d49f5985024404edcd38ebf0196467 --- /dev/null +++ b/210/TumorCenter_CD8_block20_x2_y10_patient210_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 25386.6, + "Num Detections": 20207, + "Num Negative": 18617, + "Num Positive": 1590, + "Positive %": 7.869, + "Num Positive per mm^2": 793.03 + } +} \ No newline at end of file diff --git a/210/history_text.txt b/210/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..65c1af5f8612657f27d616e6b0600c882ab6f616 --- /dev/null +++ b/210/history_text.txt @@ -0,0 +1 @@ +Histol. confirmed cT2 sonographically cN1 supraglottic. LarynxCa on the right. \ No newline at end of file diff --git a/210/icd_codes.txt b/210/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/210/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/210/ops_codes.txt b/210/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c8fc85993d828a0948fb23ab7c4788f7cdd85820 --- /dev/null +++ b/210/ops_codes.txt @@ -0,0 +1 @@ +Exzision erkranktes Gewebe Larynx endolaryngeal[5-300.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/210/patient_clinical_data.json b/210/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..915a55716b99544de8d9b19b667bc93b8d4f3ce8 --- /dev/null +++ b/210/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/210/patient_pathological_data.json b/210/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ec8b54ba9de4d5aae7f1ad2f628b3af99c5af94a --- /dev/null +++ b/210/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "210", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/210/surgery_description.txt b/210/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1f455b262d186fdd54730bbc070bdb5d19b1d046 --- /dev/null +++ b/210/surgery_description.txt @@ -0,0 +1 @@ +TORS (Transoral Robotic Surgery) procedure diff --git a/210/surgery_report.txt b/210/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c79e5c5c3592f8db9633661a0b2cb7754215fe5f --- /dev/null +++ b/210/surgery_report.txt @@ -0,0 +1 @@ +Pharyngo/laryngoscopy: Hypopharynx/supraglottis: The exophytic tumor is contact vulnerable. The main finding emanates from the posterior portion of the aryepiglottic fold on the left, with the tumor being mobile on the ary. The pocket fold is free. Cranially, the tumor extends to the level of the epiglottis attachment, but the epiglottis and vallecula are free. With a broad base, extension to the left hypopharyngeal side wall and in the medial entrance to the piriform sinus itself is very easy to unfold and free, as is the esophageal entrance. The posterior pharyngeal wall is free. No further RF in the oropharynx/hypopharynx/larynx. Setting with the mouth retractor: very good exposure, good view of the surroundings. Mark the resection margins at a safe distance with the monopolar spatula. Resection with inconspicuous tissue in the wound bed along the expansion described above. Send for def. histology. Representative marginal sampling and wound bed (above the ary). No exposed arya. Final hemostasis. All swabs complete, no more evidence of bleeding. No edema development to be expected. 250mg SDH i.v. received. Extubation without problems. post-op surgery. Recovery room, then to ENT intensive care unit. \ No newline at end of file diff --git a/211/InvasionFront_CD3_block4_x3_y5_patient211_0.json b/211/InvasionFront_CD3_block4_x3_y5_patient211_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6e3b83416d4165077e94c5751809fbae43e94e7b --- /dev/null +++ b/211/InvasionFront_CD3_block4_x3_y5_patient211_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 18590.2, + "Num Detections": 20161, + "Num Negative": 19855, + "Num Positive": 306, + "Positive %": 1.518, + "Num Positive per mm^2": 159.19 + } +} \ No newline at end of file diff --git a/211/InvasionFront_CD3_block4_x4_y5_patient211_1.json b/211/InvasionFront_CD3_block4_x4_y5_patient211_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b32f7ceaa0cd8e31c8a87e14f77628b6e0f07c05 --- /dev/null +++ b/211/InvasionFront_CD3_block4_x4_y5_patient211_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16566.2, + "Centroid Y µm": 18665.1, + "Num Detections": 18500, + "Num Negative": 18107, + "Num Positive": 393, + "Positive %": 2.124, + "Num Positive per mm^2": 202.44 + } +} \ No newline at end of file diff --git a/211/InvasionFront_CD8_block4_x3_y5_patient211_0.json b/211/InvasionFront_CD8_block4_x3_y5_patient211_0.json new file mode 100644 index 0000000000000000000000000000000000000000..11d6443a787b4457368c58618caa1e1acee670d0 --- /dev/null +++ b/211/InvasionFront_CD8_block4_x3_y5_patient211_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11269.0, + "Centroid Y µm": 17390.8, + "Num Detections": 16876, + "Num Negative": 16489, + "Num Positive": 387, + "Positive %": 2.293, + "Num Positive per mm^2": 211.9 + } +} \ No newline at end of file diff --git a/211/InvasionFront_CD8_block4_x4_y5_patient211_1.json b/211/InvasionFront_CD8_block4_x4_y5_patient211_1.json new file mode 100644 index 0000000000000000000000000000000000000000..577cebfb42af3472473e2ad2354da5bcb683fda3 --- /dev/null +++ b/211/InvasionFront_CD8_block4_x4_y5_patient211_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13967.6, + "Centroid Y µm": 17340.8, + "Num Detections": 17970, + "Num Negative": 16926, + "Num Positive": 1044, + "Positive %": 5.81, + "Num Positive per mm^2": 533.45 + } +} \ No newline at end of file diff --git a/211/TumorCenter_CD3_block4_x3_y5_patient211_0.json b/211/TumorCenter_CD3_block4_x3_y5_patient211_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fa6aaa19a621a669f38714efa324af6fb2514fa9 --- /dev/null +++ b/211/TumorCenter_CD3_block4_x3_y5_patient211_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 12743.3, + "Num Detections": 18981, + "Num Negative": 18379, + "Num Positive": 602, + "Positive %": 3.172, + "Num Positive per mm^2": 302.57 + } +} \ No newline at end of file diff --git a/211/TumorCenter_CD3_block4_x4_y5_patient211_1.json b/211/TumorCenter_CD3_block4_x4_y5_patient211_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6152aac6074c16f20fe6ec8a4226426c1f0e4142 --- /dev/null +++ b/211/TumorCenter_CD3_block4_x4_y5_patient211_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 12793.2, + "Num Detections": 20458, + "Num Negative": 19549, + "Num Positive": 909, + "Positive %": 4.443, + "Num Positive per mm^2": 454.37 + } +} \ No newline at end of file diff --git a/211/TumorCenter_CD8_block4_x3_y5_patient211_0.json b/211/TumorCenter_CD8_block4_x3_y5_patient211_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3c6bc399070f178a1abb9ef938bf5cbbf9b5658d --- /dev/null +++ b/211/TumorCenter_CD8_block4_x3_y5_patient211_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11893.7, + "Centroid Y µm": 12568.3, + "Num Detections": 19899, + "Num Negative": 19185, + "Num Positive": 714, + "Positive %": 3.588, + "Num Positive per mm^2": 360.97 + } +} \ No newline at end of file diff --git a/211/TumorCenter_CD8_block4_x4_y5_patient211_1.json b/211/TumorCenter_CD8_block4_x4_y5_patient211_1.json new file mode 100644 index 0000000000000000000000000000000000000000..57c5bd0456ca61c8560faa86ec38efc1264e860f --- /dev/null +++ b/211/TumorCenter_CD8_block4_x4_y5_patient211_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14392.4, + "Centroid Y µm": 12718.3, + "Num Detections": 21096, + "Num Negative": 20516, + "Num Positive": 580, + "Positive %": 2.749, + "Num Positive per mm^2": 291.99 + } +} \ No newline at end of file diff --git a/211/history_text.txt b/211/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4107044b52455a93c21b38d3192bcc937d29baa6 --- /dev/null +++ b/211/history_text.txt @@ -0,0 +1 @@ +The patient has had a globus sensation and hoarseness since <2015>. The panendoscopy performed in <2016> revealed a mass extending from the hypopharyngeal side wall on the left via the postcricoid region to the esophageal inlet. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/211/icd_codes.txt b/211/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..739d9698e26651477346fcfa3195fb70564f6265 --- /dev/null +++ b/211/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] \ No newline at end of file diff --git a/211/ops_codes.txt b/211/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9ddda9c1dfb79a5dea5a539a564935f8a9f99c2b --- /dev/null +++ b/211/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Permanente Tracheotomie[5-312.0 ] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] \ No newline at end of file diff --git a/211/patient_clinical_data.json b/211/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..59811e1749540b19e731c2ce43d4e9a8c35b1703 --- /dev/null +++ b/211/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/211/patient_pathological_data.json b/211/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fc30e9fe9d7e3b3847736dac495b7fd65fdd652c --- /dev/null +++ b/211/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "211", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/211/surgery_description.txt b/211/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf085921446279f802d08a1413a24436a24eaebc --- /dev/null +++ b/211/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Free flap (Radial) diff --git a/211/surgery_report.txt b/211/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b86a1d835ccbc50ad362aac335501b73720d7f2d --- /dev/null +++ b/211/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Entry with the Kleinsasser tube and inspection of the hypopharynx and larynx. The tumor begins just below the tonsil lobe on the left side, extends caudally along the hypopharyngeal side wall, infiltrates the piriform sinus completely on the left side, infiltrates the postcricoid region on both sides and continues to grow into the esophageal entrance, infiltrating it caudally for approx. 2 cm. In addition, there is a demarcated oropharyngeal carcinoma on the left side, which exists on the side wall of the oropharynx independently of the hypopharyngeal carcinoma. Positioning of the patient. Sterile washing and draping, after injection and application of an apron flap in the usual manner. Start by releasing the larynx. To do this, the hyoid bone is released, then the infrahyal muscles are detached and the oblique laryngeal muscles are detached. Perform a tracheotomy below the cricoid cartilage and transfer to a laryngectomy tube. Detachment of the thyroid gland from the thyroid cartilage skeleton on both sides. This shows that the thyroid gland on the left side is also infiltrated. It is therefore first partially resected and later completely. The piriform sinus is then released on the right side; this is not possible on the left side. On the left side, it is already clear when the larynx is released that the tumor breaks outwards almost into the soft tissues of the neck. For this reason, a suture marker is placed at a questionable location and a representative sample is taken from the soft tissue, including a marginal sample. The marginal sample was tumor-free in the frozen section. Entering the pharynx from the right side. Disluxation of the epiglottis and resection of the mucosa and tumor with integration of the oropharyngeal carcinoma and resection of the esophageal inlet and removal of the larynx below the cricoid cartilage. The tumor is thread-marked in its entirety in the frozen section. All margins are free of tumor in the frozen section. In the area of the thyroid gland, the safety margin is less than 0.5 cm. Therefore, the tumor is resected again and the remaining thyroid gland is also removed and sent to the frozen section again, also thread-marked. Now everything is tumor-free. Measurement of the defect. The result was an 18 x 8 cm defect. A left lateral esophagomyotomy was performed very carefully and then the esophagus was incised in the middle to create a V-shaped entrance. The radialis flap will later be fitted into this V-shaped entrance. For this purpose, the radialis flap is also configured in a V-shape at the tip. Then lift the radialis graft. Lifting of the radialis flap by : Drawing the flap boundaries in the presence of . An 8 x 16 cm graft is drawn in. S-shaped incision along the skin incision in the area of the proximal forearm. Incision of the distal flap borders with separation of the skin and subcutaneous tissue. Dissection in the area of the venous confluence in the crook of the elbow and identification of the superficial and deep venous system. A pronounced cephalic vein can be seen, which is integrated into the radial flap margin, extending radially. After identification of the external radial nerve ramus, it can be safely spared. Ulnar skin incision down to the deep forearm fascia. Incision of the fascia and subfascial dissection of the flap from ulnar to radial. Care is taken to leave the peritendineum intact. Dissection up to the edge of the flexor carpi radialis muscle. Identification of the vascular pedicle and application of a vascular clamp for approx. 10 minutes: during this time a good perfusion signal is continuously measured. Decision to place the flap on the distal radial stump. Clamping and cutting of the radial artery and the vena comitans. Ligation of the stent. Dissection of the vascular pedicle, also from the depths, with constant blood supply using bipolar coagulation and vascular clips. The radial nerve can be safely identified and protected on the inside of the brachioradialis muscle. Insertion of a retractor between the extensor carpi radialis muscle and the brachioradialis muscle. Dissection in the area of the bifurcation of the brachioradial artery. Now pull in and remove first the artery and then the veins. The flap can be lifted without complications. The radial artery as well as a deep and a superficial vein are available for anastomosis. This is followed by elevation of an equivalent area of split skin from the right thigh through and . Two-layer wound closure in the area of the s-shaped, proximal skin incision on the forearm. Incision of the split-thickness skin graft in the usual manner. Application of a wound dressing and a dorsal forearm splint. Application of a wrap bandage. Neck dissection is performed on both sides at the same time as flap lifting. To do this, expose the sternocleidomastoid muscle on the right side, the omohyoid muscle of the submandibular gland and the digastric muscle. Then free preparation of the cervical vascular sheath while preserving the facial vein and the superior thyroid artery and the hypoglossal nerve as well as the accessorius nerve and then release of the neck preparation II a to V a while preserving the plexus branches. Then switch to the opposite side. Here too, expose the sternocleidomastoid muscle, the omohyoid of the submandibular gland and the digastric muscle. Here too, free preparation of the internal jugular vein and the cervical vascular sheath. Then release the neck preparations II a to V a while protecting the plexus branches and the hypoglossal and accessory nerves. Deposition of the radialis graft by and closure of the wound on the forearm with split skin from the right thigh by and . Reposition the patient and perform the arterial and venous anastomosis. The superior thyroid artery, the facial vein and an outlet from the facial vein are used for this. The cephalic vein and a vein of the deep venous system of the arm are anastomosed. The radialis graft is then inserted and reconstruction of the esophageal inlet begins. For this purpose, the V-shaped defect is reconstructed through the tip of the radialis flap, which is also V-shaped. To do this, sutures are placed and then the remaining graft is sutured in place. At the end, repositioning of the apron flap and suturing of the tracheostoma. A Provox prosthesis is not possible as the esophageal entrance was too deeply infiltrated and the anterior wall had to be reconstructed with the radial flap and this will also not be possible secondarily. At the end, insertion of two Redon drains and two-layer wound closure. The flap pedicle can be doubled in the middle of the neck. A skin monitor was not possible due to the short length of the stalk, but the flap can be checked via the Doppler and also at the base of the tongue via direct inspection. At the very end, the upper edge of the flap is punctured using a cannula. A good arterial blood return is seen immediately. The patient is ventilated and admitted to the intensive care unit. After consultation with the surgeon, please continue with the X-ray paps and antibiotics for at least 24 hours. \ No newline at end of file diff --git a/212/InvasionFront_CD3_block3_x1_y1_patient212_0.json b/212/InvasionFront_CD3_block3_x1_y1_patient212_0.json new file mode 100644 index 0000000000000000000000000000000000000000..220ccf86de15b7b6bcdcfe5b2b2908b2c06aa2ca --- /dev/null +++ b/212/InvasionFront_CD3_block3_x1_y1_patient212_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7357.9, + "Centroid Y µm": 5854.7, + "Num Detections": 17064, + "Num Negative": 16815, + "Num Positive": 249, + "Positive %": 1.459, + "Num Positive per mm^2": 128.05 + } +} \ No newline at end of file diff --git a/212/InvasionFront_CD3_block3_x2_y1_patient212_1.json b/212/InvasionFront_CD3_block3_x2_y1_patient212_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d3814f64bcaccda72a85060955fe15b13bc81ff3 --- /dev/null +++ b/212/InvasionFront_CD3_block3_x2_y1_patient212_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9538.7, + "Centroid Y µm": 6451.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/212/InvasionFront_CD8_block3_x1_y1_patient212_0.json b/212/InvasionFront_CD8_block3_x1_y1_patient212_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7b72d43821fa1e8f95d6dfb1e540568fd97f393b --- /dev/null +++ b/212/InvasionFront_CD8_block3_x1_y1_patient212_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5161.2, + "Centroid Y µm": 2660.1, + "Num Detections": 14055, + "Num Negative": 13950, + "Num Positive": 105, + "Positive %": 0.7471, + "Num Positive per mm^2": 57.43 + } +} \ No newline at end of file diff --git a/212/InvasionFront_CD8_block3_x2_y1_patient212_1.json b/212/InvasionFront_CD8_block3_x2_y1_patient212_1.json new file mode 100644 index 0000000000000000000000000000000000000000..07aa59a12921160ad6cee5b04b94e37564c3cf0d --- /dev/null +++ b/212/InvasionFront_CD8_block3_x2_y1_patient212_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7715.0, + "Centroid Y µm": 2584.9, + "Num Detections": 15434, + "Num Negative": 15284, + "Num Positive": 150, + "Positive %": 0.9719, + "Num Positive per mm^2": 73.1 + } +} \ No newline at end of file diff --git a/212/TumorCenter_CD3_block3_x1_y1_patient212_0.json b/212/TumorCenter_CD3_block3_x1_y1_patient212_0.json new file mode 100644 index 0000000000000000000000000000000000000000..acd9d5d3b0b02a5e5bcc24ed3f2fa8befd4c13c3 --- /dev/null +++ b/212/TumorCenter_CD3_block3_x1_y1_patient212_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3742.4, + "Centroid Y µm": 7882.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/212/TumorCenter_CD3_block3_x2_y1_patient212_1.json b/212/TumorCenter_CD3_block3_x2_y1_patient212_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8451a187153ccf35816750decdc6c22974f58279 --- /dev/null +++ b/212/TumorCenter_CD3_block3_x2_y1_patient212_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6208.2, + "Centroid Y µm": 8307.2, + "Num Detections": 11130, + "Num Negative": 10170, + "Num Positive": 960, + "Positive %": 8.625, + "Num Positive per mm^2": 629.41 + } +} \ No newline at end of file diff --git a/212/TumorCenter_CD8_block3_x1_y1_patient212_0.json b/212/TumorCenter_CD8_block3_x1_y1_patient212_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3b28ee603805d2b2636a9fe50be929a1c0a1b2dd --- /dev/null +++ b/212/TumorCenter_CD8_block3_x1_y1_patient212_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5022.3, + "Centroid Y µm": 4197.8, + "Num Detections": 24177, + "Num Negative": 22258, + "Num Positive": 1919, + "Positive %": 7.937, + "Num Positive per mm^2": 784.61 + } +} \ No newline at end of file diff --git a/212/TumorCenter_CD8_block3_x2_y1_patient212_1.json b/212/TumorCenter_CD8_block3_x2_y1_patient212_1.json new file mode 100644 index 0000000000000000000000000000000000000000..11df8bf6c04506ae6d70b38dd6a0727760a0769a --- /dev/null +++ b/212/TumorCenter_CD8_block3_x2_y1_patient212_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7646.0, + "Centroid Y µm": 4247.8, + "Num Detections": 20211, + "Num Negative": 20037, + "Num Positive": 174, + "Positive %": 0.8609, + "Num Positive per mm^2": 68.72 + } +} \ No newline at end of file diff --git a/212/history_text.txt b/212/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6bfb6d4b0c75419d88a7e846cb9d914df08b5a08 --- /dev/null +++ b/212/history_text.txt @@ -0,0 +1 @@ +The patient was informed in detail about the planned procedure for the above-mentioned indication. \ No newline at end of file diff --git a/212/icd_codes.txt b/212/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/212/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/212/ops_codes.txt b/212/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7a934a5af51e57d6a2002cec83315ca932576bda --- /dev/null +++ b/212/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx mit Rekonstruktion mit lokaler Schleimhaut[5-296.01 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Epiglottektomie endolaryngeal[5-302.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/212/patient_clinical_data.json b/212/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6922d3987ac056cc55e3d727696511bbcbf8e2bc --- /dev/null +++ b/212/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 70, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/212/patient_pathological_data.json b/212/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2a02e1f5af3dd1b481fb178f6346bc94d66a7e12 --- /dev/null +++ b/212/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "212", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Sarcomatoid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/212/surgery_description.txt b/212/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8e734db6711fec8f6d4a58282790ca5f7fe88ce --- /dev/null +++ b/212/surgery_description.txt @@ -0,0 +1 @@ +TORS resection, Tracheotomy, Neck dissection, PEG placement diff --git a/212/surgery_report.txt b/212/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e390b2c0e47ea55aff5d739fa411eb0d51a15f15 --- /dev/null +++ b/212/surgery_report.txt @@ -0,0 +1 @@ +After induction of intubation anesthesia, repeated endoscopy and inspection of the tumor. An extensive exophytic mass was found, which covered the entire vallecula, infiltrated the base of the tongue on the left side and also infiltrated the lingual epiglottis up to the base. The tumor extends laterally to the pharyngo-epiglottic fold, but does not pass through it, so that the piriform sinus itself is free. Now add the flexible esophagoscope and endoscopy of the esophagus. Advance the instrument into the stomach. If the diaphanoscopy is positive, PEG insertion using the thread pull-through method and if the tent phenomenon is positive. The insertion is successful without any problems. Then suction out the insufflated air after fixing the PEG and withdrawing the esophagoscope. The patient is then repositioned. Now extremely laborious insertion of the TORS blocker. The tumor is only partially exposed. A complete overview is initially not possible due to the bulging base of the tongue. After insertion and docking of the DaVinci robot. Then first retraction of the base of the tongue. The full extent of the tumor can now be seen. Therefore, first traverse the tumor borders with the monopolar spatula. The tumor infiltrates the base of the tongue on the left side. Therefore, start resection at the base of the tongue. Extremely careful dissection here after the resection extends into the depths. However, the lingual artery is not exposed and remains intact. Then resection laterally and medially. Capture the tumor border in the vallecula. This crosses the midline here. Then further resection of the epiglottis. It can be seen that the tumor has almost completely infiltrated the lingual surface of the epiglottis, so that a complete epiglottectomy must be performed. The pocket folds and the endolaryngeal supraglottis are completely tumor-free. The two arytenoid cartilages are also spared from the resection and remain intact. The resection is then performed laterally via the pharyngo-epiglottic fold. Finally, the tumor can be incised in depth and resected in several parts using a piecemeal technique. Representative marginal samples are then taken from the medial as well as lateral, ventral, dorsal and deep settling areas. Some vascular stumps, particularly on the lateral pharyngeal wall, are first exposed and then clipped. A dry wound surface is then revealed underneath. All frozen sections are diagnosed intraoperatively by the pathology colleagues as tumor-free. If the wound is dry, the DaVinci robot is undocked. The patient was then repositioned for ipsilateral neck dissection on the left side. Injection of local anesthetic with adrenaline. Then incision on the anterior edge of the sternocleidomastoid muscle. Dissection in depth in layers. Exposure of the omohyoid muscle and the posterior digaster venter muscle. Exposure of the accessorius nerve and subsequent insertion of the retractors. Then dissection of the glandular capsule. Clearing of the hypoglossal triangle with exposure of the hypoglossus while sparing all branches of the external carotid artery and internal jugular artery. Followed by a long dissection of the cervical vascular sheath with exposure and protection of the vagus nerve. Subsequent removal of the lateral neck preparation. Then clearing of the ventral neck preparation up to the upper edge of the thyroid gland. Here too, all vessels and nerves are protected. This results in a neck dissection level Ib, II, III, IV and V. A Redon drain is then inserted and the wound is closed in several layers. The patient is then repositioned, initially for tracheotomy. Here too, injection of local anesthetic with adrenaline. Then skin incision in the sense of a modified Kocher incision. Layer-by-layer preparation in depth. Dissection and ligation of several larger pretracheal veins. Then locate the midline and separate the muscles. Further layered dissection in depth. Exposure of the thyroid isthmus. Once this has been undermined, clamp off the thyroid isthmus on both sides and cut through it. The thyroid gland is then repositioned on both sides and the front of the trachea is exposed. Exposure of the cricoid cartilage. Then incision of the trachea between the 2nd and 3rd cartilage clasp. Opening of the trachea. Preparation of a Björk flap. Then suturing of the tracheostoma in the sense of a circular mucocutaneous anastomosis. The patient is then repositioned for neck dissection on the right side. The procedure here is identical to that on the left side. Here too, a skin incision is made along the anterior border of the sternocleidomastoid muscle. Expose the omohyoid muscle and digaster venter posterior muscle. Exposure of the accessorius nerve and insertion of the retractors. Clearing of the hypoglossal triangle while sparing all branches of the external carotid artery, the internal jugular artery and the hypoglossal nerve. Long dissection of the cervical vascular sheath while sparing the vagus nerve. Dissection of the lateral neck preparation and the anterior neck preparation, again sparing all vascular and nerve structures. This also results in a level Ib to V neck dissection. Subtle hemostasis is also performed here. Then insertion of a Redon drain and two-layer wound closure. The patient is then intubated from the transnasal tube to the tracheostomy tube. This is done without difficulty. After applying a cervical pressure bandage on both sides, the procedure is completed. On the ipsilateral tumor side, several enlarged lymph nodes in the sense of an N2b neck status were found. The right side was clinically unremarkable. Therefore, this is at least a T3 hypopharyngeal carcinoma with a clinical N2b neck status. The final further procedure must then be decided at the interdisciplinary tumor conference after receipt of the final histology. \ No newline at end of file diff --git a/213/InvasionFront_CD3_block15_x3_y9_patient213_0.json b/213/InvasionFront_CD3_block15_x3_y9_patient213_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7df078b46f9f30f84e996cf1670b7fe18d06d815 --- /dev/null +++ b/213/InvasionFront_CD3_block15_x3_y9_patient213_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 32657.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/213/InvasionFront_CD3_block15_x4_y9_patient213_1.json b/213/InvasionFront_CD3_block15_x4_y9_patient213_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf94b49a24a65906b70ea0204b5d447167614869 --- /dev/null +++ b/213/InvasionFront_CD3_block15_x4_y9_patient213_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 32482.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/213/InvasionFront_CD8_block15_x3_y9_patient213_0.json b/213/InvasionFront_CD8_block15_x3_y9_patient213_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e680dd87a87c5f187b953c95bb43c87f119b6fb9 --- /dev/null +++ b/213/InvasionFront_CD8_block15_x3_y9_patient213_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11471.1, + "Centroid Y µm": 22154.7, + "Num Detections": 16525, + "Num Negative": 15614, + "Num Positive": 911, + "Positive %": 5.513, + "Num Positive per mm^2": 472.37 + } +} \ No newline at end of file diff --git a/213/InvasionFront_CD8_block15_x4_y9_patient213_1.json b/213/InvasionFront_CD8_block15_x4_y9_patient213_1.json new file mode 100644 index 0000000000000000000000000000000000000000..571ed17eb962af5d57560abe374a46ae25b6062b --- /dev/null +++ b/213/InvasionFront_CD8_block15_x4_y9_patient213_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14025.8, + "Centroid Y µm": 22023.2, + "Num Detections": 16139, + "Num Negative": 13517, + "Num Positive": 2622, + "Positive %": 16.25, + "Num Positive per mm^2": 1319.5 + } +} \ No newline at end of file diff --git a/213/TumorCenter_CD3_block15_x3_y9_patient213_0.json b/213/TumorCenter_CD3_block15_x3_y9_patient213_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ae4e983392b5ced472f37fdd785170d6b05fd069 --- /dev/null +++ b/213/TumorCenter_CD3_block15_x3_y9_patient213_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11244.0, + "Centroid Y µm": 25911.3, + "Num Detections": 11815, + "Num Negative": 8633, + "Num Positive": 3182, + "Positive %": 26.93, + "Num Positive per mm^2": 1930.6 + } +} \ No newline at end of file diff --git a/213/TumorCenter_CD3_block15_x4_y9_patient213_1.json b/213/TumorCenter_CD3_block15_x4_y9_patient213_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9b24fd5ba86caa4d7b849a024357267f7a7fc0c1 --- /dev/null +++ b/213/TumorCenter_CD3_block15_x4_y9_patient213_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 25886.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/213/TumorCenter_CD8_block15_x3_y9_patient213_0.json b/213/TumorCenter_CD8_block15_x3_y9_patient213_0.json new file mode 100644 index 0000000000000000000000000000000000000000..354b8a4ceb20dd50cc8251016382008b652b0c3e --- /dev/null +++ b/213/TumorCenter_CD8_block15_x3_y9_patient213_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 22488.1, + "Num Detections": 17317, + "Num Negative": 16071, + "Num Positive": 1246, + "Positive %": 7.195, + "Num Positive per mm^2": 560.43 + } +} \ No newline at end of file diff --git a/213/TumorCenter_CD8_block15_x4_y9_patient213_1.json b/213/TumorCenter_CD8_block15_x4_y9_patient213_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c8632fbfd7833a2549847f78de105e9f7ea7a583 --- /dev/null +++ b/213/TumorCenter_CD8_block15_x4_y9_patient213_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 22438.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/213/history_text.txt b/213/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb4a07746e23193d7278c083fcf12ea7305e05a0 --- /dev/null +++ b/213/history_text.txt @@ -0,0 +1 @@ +Mr. has a histologically confirmed right tongue margin carcinoma cT2 cN0 cM0. In our tumor conference <2014> a tumor resection with neck dissection and functional cyst in the left lobe of the thyroid gland was determined. \ No newline at end of file diff --git a/213/icd_codes.txt b/213/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7dc878bf2f7941b63992696787daf08badd13d5e --- /dev/null +++ b/213/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 R] gestern ausgefallen! Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/213/ops_codes.txt b/213/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..89e7522a8a1dd55cf6d5049d334f3d54c9915681 --- /dev/null +++ b/213/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral Rekonstruktion mit nicht vaskularisiertem Transplantat[5-251.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] \ No newline at end of file diff --git a/213/patient_clinical_data.json b/213/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e143e668ebfe1cc91ef4399af57bfc86f8a34f65 --- /dev/null +++ b/213/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/213/patient_pathological_data.json b/213/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a14710c5c2b6afa6d01a57ffab9da671fcdb9945 --- /dev/null +++ b/213/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "213", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/213/surgery_description.txt b/213/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f0815e8af6780f5b4c5b15529fb738ace1c4db84 --- /dev/null +++ b/213/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Selective right neck dissection diff --git a/213/surgery_report.txt b/213/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d3da021c6b73300db812ecbfaeeb9a19b725e575 --- /dev/null +++ b/213/surgery_report.txt @@ -0,0 +1 @@ +After transnasal intubation of the patient by the anesthesia colleague, the patient is positioned. Insertion of the Jennings mouth retractor and inspection of the oral cavity. An exophytic mass with a diameter of 2.4 x 1.4 cm is found at the edge of the tongue/under the tongue in the middle of the posterior 1/3 of the free tongue. The palpatory mass partially grows into the tongue musculature. Next, the tongue is pulled out. An incision is now made in the mucosa 1-1.2 cm from the macroscopic edge of the tumor. Dissection in depth and simultaneous targeted bipolar coagulation. Approx. 1.5 cm of the tongue musculature was removed in depth together with the main preparation. Careful resection down to the tongue musculature. After dissection, the resection margin was sharply separated. Nerve fibers of the lingual nerve are identified here, resected and sent separately for histological analysis. Targeted bipolar hemostasis from bleeding vessels. Exposure of the whartonian duct at the posterior lower resection margin. After removal of the specimen, the specimen is marked and sent for frozen section analysis. Tamponade of the oral cavity and sterile washing and covering of the right side of the neck. As the patient has several secondary diseases, the administration of infiltration was not authorized. Creation of an 8 cm skin incision on the anterior border of the sternocleidomastoid. Sharp transection of the platysma and identification of the superficial cervical fascia. Resection of the connecting vein between the anterior jugular artery and the external jugular artery. Identification of the auricularis magnus nerve and preservation of the same. Then cranial dissection and identification of the marginal ramus and facial nerve. Next, dissection in depth until identification of the anterior sternocleidomastoid. Level III revealed a very interestingly split sternocleidomastoid muscle. Even in this area, 2 different heads (attachment to the sternum and attachment to the clavicle) are identified. Further dissection cranially until identification of the accessorius nerve. Level IIb is completely dissected above the accessorius nerve and the internal jugular vein is exposed. Level IIb is then pulled out under the accessorius nerve. Further dissection along the sternocleidomastoid muscle in depth. After identification of the cervical plexus posteriorly and the omohyoid muscle caudally, the lateral preparations are detached from lateral to medial. The cervical vascular sheath is then identified and dissected above the jugular vein and the carotid artery anteriorly. Then identification of the infrahyoid musculature and slow dissection from bottom to top. Preservation of the neurovascular structures, in particular the hypoglossal nerve and lingual artery. The preparation is then removed practically in one piece. Next, dissection in level Ia. A relatively large lymph node is removed separately above the submandibular gland and medially from the submandibular gland in the area of the facial artery and sent separately for histological analysis. Here, demonstration of the findings to . Decision to remove level Ia. After identification of the anterior venter, digastric muscle and corpus ossis hyoidei, level Ia is systematically dissected from caudal to cranial. Upward identification of the mylohyoid muscle and sharp separation of the specimen from the muscle. The specimen is sent separately in one piece for histological analysis. Targeted bipolar hemostasis in all regions. In the event of absolute hemostasis, a size C Redon drain is placed. Wound closure in layers. Then transition to the oral cavity. After removing the compresses, targeted bipolar hemostasis is performed from the small bleeding vessels in the tongue musculature. Layered primary closure of the edge of the tongue on the right. If the postoperative aspect is relatively dry, the patient is handed over to the anesthesia colleague. Completion of the surgical procedure without complications. Conclusion: Resection of tongue margin carcinoma cT2 cN0 cM0 on the right and selective neck dissection level Ia to level IV on the right is performed without complications. For technical reasons, puncture from the left lobe of the thyroid gland was postponed. Intraoperative frozen section examination showed a distance of more than 0.5 cm from the lateral edges and at least 0.5 cm in the basal area. Therefore, primary wound closure at the right tongue margin. In case of unfavorable histological criteria and depth of infiltration and infiltration of the lingual nerve, adjuvant radiochemotherapy should be performed. If an intraoperative injury to tooth 23 is suspected, the patient should be seen by a dentist postoperatively. Postoperatively, antibiotics with Unacid 3 x 3 g and Clont 3 x 500 mg should be administered for the next 3 days under gastric protection. Redon drainage depending on progress. Early mobilization. Soft food build-up possible from the 2nd postoperative day. \ No newline at end of file diff --git a/214/InvasionFront_CD3_block5_x1_y8_patient214_0.json b/214/InvasionFront_CD3_block5_x1_y8_patient214_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0832184a1c22776f5afa5c412d842f7d916209de --- /dev/null +++ b/214/InvasionFront_CD3_block5_x1_y8_patient214_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3947.9, + "Centroid Y µm": 20414.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/214/InvasionFront_CD3_block5_x2_y8_patient214_1.json b/214/InvasionFront_CD3_block5_x2_y8_patient214_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a7da438751fe43b76f7af8a9da95fd0909babe98 --- /dev/null +++ b/214/InvasionFront_CD3_block5_x2_y8_patient214_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 20314.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/214/InvasionFront_CD8_block5_x1_y6_patient214_0.json b/214/InvasionFront_CD8_block5_x1_y6_patient214_0.json new file mode 100644 index 0000000000000000000000000000000000000000..847d19b372f4555a474151ff98b5ce1ff179cc37 --- /dev/null +++ b/214/InvasionFront_CD8_block5_x1_y6_patient214_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 15192.0, + "Num Detections": 24972, + "Num Negative": 17652, + "Num Positive": 7320, + "Positive %": 29.31, + "Num Positive per mm^2": 2891.1 + } +} \ No newline at end of file diff --git a/214/InvasionFront_CD8_block5_x2_y6_patient214_1.json b/214/InvasionFront_CD8_block5_x2_y6_patient214_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4d2f1b72cb618860655557c85d273145ec15f1e0 --- /dev/null +++ b/214/InvasionFront_CD8_block5_x2_y6_patient214_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 15142.0, + "Num Detections": 24748, + "Num Negative": 16032, + "Num Positive": 8716, + "Positive %": 35.22, + "Num Positive per mm^2": 3429.6 + } +} \ No newline at end of file diff --git a/214/TumorCenter_CD3_block5_x1_y6_patient214_0.json b/214/TumorCenter_CD3_block5_x1_y6_patient214_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e65b4367f7bec845ca0255ce424b8829a4bc97e2 --- /dev/null +++ b/214/TumorCenter_CD3_block5_x1_y6_patient214_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4547.6, + "Centroid Y µm": 14217.5, + "Num Detections": 19330, + "Num Negative": 13779, + "Num Positive": 5551, + "Positive %": 28.72, + "Num Positive per mm^2": 2356.2 + } +} \ No newline at end of file diff --git a/214/TumorCenter_CD3_block5_x2_y6_patient214_1.json b/214/TumorCenter_CD3_block5_x2_y6_patient214_1.json new file mode 100644 index 0000000000000000000000000000000000000000..90d54018e7f4e85183541bed7d8281b721fd8420 --- /dev/null +++ b/214/TumorCenter_CD3_block5_x2_y6_patient214_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7096.2, + "Centroid Y µm": 14392.4, + "Num Detections": 21732, + "Num Negative": 9935, + "Num Positive": 11797, + "Positive %": 54.28, + "Num Positive per mm^2": 4932.2 + } +} \ No newline at end of file diff --git a/214/TumorCenter_CD8_block5_x1_y6_patient214_0.json b/214/TumorCenter_CD8_block5_x1_y6_patient214_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e6e06af65cc15c58715a494a1e2b90b54ba066c0 --- /dev/null +++ b/214/TumorCenter_CD8_block5_x1_y6_patient214_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 14917.1, + "Num Detections": 20706, + "Num Negative": 15087, + "Num Positive": 5619, + "Positive %": 27.14, + "Num Positive per mm^2": 2354.7 + } +} \ No newline at end of file diff --git a/214/TumorCenter_CD8_block5_x2_y6_patient214_1.json b/214/TumorCenter_CD8_block5_x2_y6_patient214_1.json new file mode 100644 index 0000000000000000000000000000000000000000..94e59bd570b7cb746d6b37d025de9c12dcafeb05 --- /dev/null +++ b/214/TumorCenter_CD8_block5_x2_y6_patient214_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 14942.1, + "Num Detections": 22048, + "Num Negative": 10341, + "Num Positive": 11707, + "Positive %": 53.1, + "Num Positive per mm^2": 4881.9 + } +} \ No newline at end of file diff --git a/214/history_text.txt b/214/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f5c29eac82a07d83b1052bd1dd63fdd2004101c0 --- /dev/null +++ b/214/history_text.txt @@ -0,0 +1 @@ +The patient showed extensive cervical lymph node metastasis, more on the left than on the right, cervically on both sides. A gross needle biopsy of the cervical lymph node metastasis on the left side revealed infiltration by a squamous cell carcinoma. After an unremarkable panendoscopy, a PET-CT was performed, which showed bilateral enhancement in the tonsil region on both sides, which is why a tumor tonsillectomy was indicated. \ No newline at end of file diff --git a/214/icd_codes.txt b/214/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4425b26a2da20858ce10ab1e429b7462c88b35fd --- /dev/null +++ b/214/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Tonsille mehrere Teilbereiche überlappend[C09.8 B] Neubildung bösartig Halslymphknoten[C77.0 B] \ No newline at end of file diff --git a/214/ops_codes.txt b/214/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..83dd89ed2d629e02c9bdebb0aae2efeea5f442a4 --- /dev/null +++ b/214/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/214/patient_clinical_data.json b/214/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d2c2b5db7fc8b11487b636fff43301f2681ddd21 --- /dev/null +++ b/214/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 66, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/214/patient_pathological_data.json b/214/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8f29ccfe6962ae58271dca29a54ad140ebaa740b --- /dev/null +++ b/214/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "214", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN3", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 12.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/214/surgery_description.txt b/214/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f75c9e62515314d86f48337a4e367d756dffcd2b --- /dev/null +++ b/214/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Bilateral neck dissection; Inspection of oral cavity and oropharynx diff --git a/214/surgery_report.txt b/214/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e50649a8511d6e7c7c0627481731ffa25254b79c --- /dev/null +++ b/214/surgery_report.txt @@ -0,0 +1 @@ +Preliminary consultation with the anesthetist. Insertion of the mouth guard. Inspection of the oral cavity and oropharynx, where a suspicious formation is seen in the area of the tonsils on both sides. On the left side, this is now relatively clear compared to the panendoscopy a few weeks ago, which is why a tumor tonsillectomy is performed on the left side. On the right side, a biopsy is taken from the tonsil. The tumor tonsillectomy and the biopsy of the tonsil on the right side both go to frozen section diagnostics. Surprisingly, both findings were found to be infiltration by a tonsillar carcinoma in the frozen section. Subsequently, resection in the area of the left tonsil, in the area of the anterior and posterior palatal arch and dissection down to the muscles of the pharynx. Significant resection in the area of the posterior palatal arch, where the frozen section also showed infiltrates of the tonsillar carcinoma. Here, new specimens are taken from the margins, representing the entire margins of the deposit including the deep deposit towards the pharyngeal muscle area. All findings are diagnosed as tumor-free in the frozen section. Creation of a palatal arch plasty. Perform a subtle hemostasis. Since no fatty tissue is exposed here, neck dissection of the left side should be possible without any problems. Then perform the tumor tonsillectomy after obtaining the frozen section on the right side. The tumor appears to be limited exclusively to the tonsil. Here too, resection is performed down to the area of the pharyngeal muscles. Representative marginal samples are then taken and also sent for frozen section examination. These marginal samples are also diagnosed as tumor-free in the frozen section. Creation of a palatal arch plasty. Subtle hemostasis is then also performed here. Repositioning of the patient to attempt PEG placement. This was performed without any problems up to the stomach. A hiatal hernia is suspected here. If the diaphanoscopy is not positive, the PEG tube is not inserted. In this case, the gastroenterology or surgical colleagues should insert the PEG. Decision to insert a nasogastric feeding tube for the postoperative phase. This works without any problems. The patient is repositioned for neck dissection on both sides: Start on the left side. The metastasis has broken through at the posterior edge of the sternocleidomastoid muscle with infiltration of the skin. Therefore, the incision was moved slightly dorsally and a skin spindle was cut around. At the dorsal edge of the resection, a sample was taken from the edge of the skin, which was still diagnosed as tumor infiltrated in the frozen section. Therefore, resection in this area and resubmission of frozen sections after renewed removal of marginal samples. Subsequently, further dissection and visualization of the cervical vascular sheath. It became apparent that the metastasis had completely infiltrated both the branches of the auricularis magnus nerve and the accessorius nerve from the deep cervical fascia, so that a modified radical neck dissection with partial resection of the sternocleidomastoid muscle and the accessorius nerve had to be performed. Displacement and, at the end of the operation, re-embedding of the auricularis magnus nerve in the sense of a neurolysis. Only the anterior edge of the sternocleidomastoid muscle remains to cover the cervical vascular sheath. Exposure, long-distance dissection and displacement as well as re-embedding of the vagus nerve at the end of the operation in the sense of a neurolysis. Subsequent further dissection of the entire lateral neck in terms of levels II, III, IV and V. Dissection of the cervical vascular sheath and here dissection of the anterior neck preparation. There are conspicuously enlarged lymph nodes everywhere. Exposure of the hypoglossal nerve and clearing of the hypoglossal triangle. All branches of the external carotid artery and internal jugular vein are spared. Displacement and, at the end of the operation, re-embedding of the hypoglossal nerve in the sense of a neurolysis. This results in a neck dissection of level I b up to and including V. The specimen is sent for histopathological evaluation. With a free marginal specimen in the area of the skin's edge, two-layer wound closure. Insertion of a Redon drainage. Transition to neck dissection of the right side. Here too, skin incision along the anterior edge of the sternocleidomastoid muscle. Dissection in depth in layers and exposure of the cervical vascular sheath. A larger metastasis can be seen in the area of the venous angle, which lies on the hypoglossal nerve and must be dissected away from it. Clearing of the hypoglossal triangle. Displacement and, at the end of the operation, re-embedding of the hypoglossal nerve in the sense of a neurolysis. Exposure of the cervical vascular sheath and long-distance dissection of the contents of the cervical vascular sheath with the vessels and the vagus nerve. Long-distance dissection of the accessorius nerve. Displacement and, at the end of the operation, re-embedding of the vagus nerve and accessorius nerve in the sense of a neurolysis. Clearing of the entire lateral neck preparation in the sense of levels II to V. Numerous suspiciously enlarged lymph nodes are also found here. After careful hemostasis, there is no further resistance on palpation. Again, evacuation of the anterior neck preparation and further subtle hemostasis. Irrigation of the wound. Two-layer wound closure. Insertion of a Redon drain. Application of a pressure dressing on both sides. Final consultation with the anesthetist. Completion of the procedure. \ No newline at end of file diff --git a/215/InvasionFront_CD3_block11_x1_y2_patient215_0.json b/215/InvasionFront_CD3_block11_x1_y2_patient215_0.json new file mode 100644 index 0000000000000000000000000000000000000000..76ad8c74a4fee55382d3c181cabd747bdf2d4395 --- /dev/null +++ b/215/InvasionFront_CD3_block11_x1_y2_patient215_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3073.4, + "Centroid Y µm": 5072.3, + "Num Detections": 18980, + "Num Negative": 17235, + "Num Positive": 1745, + "Positive %": 9.194, + "Num Positive per mm^2": 776.74 + } +} \ No newline at end of file diff --git a/215/InvasionFront_CD3_block11_x2_y2_patient215_1.json b/215/InvasionFront_CD3_block11_x2_y2_patient215_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fab758146faa5185e3830b1bbcd8fcc6a40da7f4 --- /dev/null +++ b/215/InvasionFront_CD3_block11_x2_y2_patient215_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5722.0, + "Centroid Y µm": 5047.3, + "Num Detections": 24250, + "Num Negative": 20501, + "Num Positive": 3749, + "Positive %": 15.46, + "Num Positive per mm^2": 1464.1 + } +} \ No newline at end of file diff --git a/215/InvasionFront_CD8_block11_x1_y2_patient215_0.json b/215/InvasionFront_CD8_block11_x1_y2_patient215_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dc4ff49d0dffbed23ea1f6b6881b036f7e90a859 --- /dev/null +++ b/215/InvasionFront_CD8_block11_x1_y2_patient215_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6145.2, + "Centroid Y µm": 15653.8, + "Num Detections": 19075, + "Num Negative": 18348, + "Num Positive": 727, + "Positive %": 3.811, + "Num Positive per mm^2": 326.04 + } +} \ No newline at end of file diff --git a/215/InvasionFront_CD8_block11_x2_y2_patient215_1.json b/215/InvasionFront_CD8_block11_x2_y2_patient215_1.json new file mode 100644 index 0000000000000000000000000000000000000000..05555c15bab6fca116ad9571eb8b47866b707834 --- /dev/null +++ b/215/InvasionFront_CD8_block11_x2_y2_patient215_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8893.2, + "Centroid Y µm": 15530.7, + "Num Detections": 22883, + "Num Negative": 21907, + "Num Positive": 976, + "Positive %": 4.265, + "Num Positive per mm^2": 390.3 + } +} \ No newline at end of file diff --git a/215/TumorCenter_CD3_block11_x1_y2_patient215_0.json b/215/TumorCenter_CD3_block11_x1_y2_patient215_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ef4b886516f06f6ed16b60b6151832d1f323dcb3 --- /dev/null +++ b/215/TumorCenter_CD3_block11_x1_y2_patient215_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7421.1, + "Centroid Y µm": 4972.4, + "Num Detections": 25033, + "Num Negative": 24565, + "Num Positive": 468, + "Positive %": 1.87, + "Num Positive per mm^2": 206.94 + } +} \ No newline at end of file diff --git a/215/TumorCenter_CD3_block11_x2_y2_patient215_1.json b/215/TumorCenter_CD3_block11_x2_y2_patient215_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3ee10c13c0ac9ce24f157f5403db88757281ae84 --- /dev/null +++ b/215/TumorCenter_CD3_block11_x2_y2_patient215_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10144.6, + "Centroid Y µm": 4747.5, + "Num Detections": 23683, + "Num Negative": 22360, + "Num Positive": 1323, + "Positive %": 5.586, + "Num Positive per mm^2": 586.26 + } +} \ No newline at end of file diff --git a/215/TumorCenter_CD8_block11_x1_y2_patient215_0.json b/215/TumorCenter_CD8_block11_x1_y2_patient215_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6b3d0949f7831f485d2d998d25888c93673dc25c --- /dev/null +++ b/215/TumorCenter_CD8_block11_x1_y2_patient215_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4772.5, + "Centroid Y µm": 4697.5, + "Num Detections": 11102, + "Num Negative": 10848, + "Num Positive": 254, + "Positive %": 2.288, + "Num Positive per mm^2": 232.59 + } +} \ No newline at end of file diff --git a/215/TumorCenter_CD8_block11_x2_y2_patient215_1.json b/215/TumorCenter_CD8_block11_x2_y2_patient215_1.json new file mode 100644 index 0000000000000000000000000000000000000000..49dbda37079f4b7122df667d537a5262c0389d04 --- /dev/null +++ b/215/TumorCenter_CD8_block11_x2_y2_patient215_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7596.0, + "Centroid Y µm": 4747.5, + "Num Detections": 22044, + "Num Negative": 21541, + "Num Positive": 503, + "Positive %": 2.282, + "Num Positive per mm^2": 228.1 + } +} \ No newline at end of file diff --git a/215/history_text.txt b/215/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..97845576a311e946e45bface21c7185410c0d24a --- /dev/null +++ b/215/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma in the area of the base of the tongue, vallecula and pharyngeal wall on the left. Laser resection not possible due to extremely poor adjustability. Surgery primarily planned with tumor removal from the outside. \ No newline at end of file diff --git a/215/icd_codes.txt b/215/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed4aa87497852c75f601688357848e31931e81a2 --- /dev/null +++ b/215/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/215/ops_codes.txt b/215/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b9386100a83163e792e56857db88a3d274b3e8b6 --- /dev/null +++ b/215/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Temporäre Tracheotomie[5-311.0 ] Transplantation fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.53 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhautdeckung großflächig Empfängerstelle Unterarm[5-902.68 L] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/215/patient_clinical_data.json b/215/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c759858959e1fb824d66787003868523b992238c --- /dev/null +++ b/215/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 51, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/215/patient_pathological_data.json b/215/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b1e617b89455d4d4e1640c5044500d7acf9aa956 --- /dev/null +++ b/215/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "215", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/215/surgery_description.txt b/215/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8fdbf276b03ba852c500dd47a3c891c575cee32 --- /dev/null +++ b/215/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheostomy diff --git a/215/surgery_report.txt b/215/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..49add35aaa2b54f44323868c06de28ee6e77f413 --- /dev/null +++ b/215/surgery_report.txt @@ -0,0 +1 @@ +This is followed by bronchoscopic intubation by the anesthesia colleagues. Followed by pharyngoscopy again: once again, the small bore tube size C and D is used. Although the tumor can be visualized, its extent is barely detectable with the small bore tube. This once again confirms the indication for an external approach. This is followed by repositioning, injection of a total of 20 ml xylocaine 1% with adrenaline in the area of both sides of the neck and sterile draping. Start with modified apron flaps: The right apron flap is lifted in a typical manner, slightly widened caudally on the left, in order to also develop a platysmal flap from this to cover the defect in the tongue base area if necessary. The flap is elevated to the level of the hyoid bone or the submandibular gland. Neck dissection on the left side: exposure of the sternocleidomastoid muscle anterior border. Dissection of lymph node fat packet. Exposure of the cervical vascular sheath, internal jugular vein, internal/external carotid artery. Exposure of vagus nerve, accessorius nerve. Development of the dorsal neck preparation with exposure and preservation of the branches of the cervical plexus. Then develop the anterior neck preparation, exposing and preserving the superior thyroid artery and the hypoglossal nerve. Exposure and preservation of the cervical artery. This results in an evacuation of levels II to V on the left. Neck dissection on the right side: This is performed in the same way as on the left side, exposing the structures mentioned, which are also preserved. Level II to IV removal is performed here, followed by transcervical tumor resection: exposure and skeletonization of the hyoid bone. The pre-epiglottic fatty tissue is completely removed behind the hyoid bone. This is also removed from the right to the left of the epiglottis and integrated into the tumor preparation. Right paramedian entry into the larynx at the level of the epiglottis. The tumor can now be visualized, viewed with relative difficulty and successively removed by means of inspection and palpation. Tumor is incised on all sides with a safety margin of 1 to 1.5 cm and removed in toto. Two thirds of the epiglottis is freed from the lingual mucosa. The left pharyngeal wall is removed, the base of the tongue is removed by about two thirds, whereby the resection to the right is not too deep, so that the lingualis can be spared here. Resection extends in the area of the pharyngeal wall to just before the tonsil lobe. Tumor is removed and marked with a suture. Due to the relative proximity caudally in the area of the epiglottis, a strip of mucosa is removed from the epiglottis area, which corresponds to the rest of the epiglottis mucosa lingually. The tumor is removed in the frozen section towards all edges in the healthy area, but small focal in-situ infiltrations are still visible in the area of the mucosa sample of the remainder of the lingual epiglottis. Therefore, the tip of the epiglottis is removed, the left third and a thick strip of mucosa in the direction of the arytenoid fold and pharyngeal wall. This preparation is thread-marked and sent for frozen section examination, whereby the side remote from the tumor is marked. There are no more infiltrates here, so that an R0 resection can now be assumed. This results in a defect of two thirds of the tongue base mucosa area, the pharyngeal wall on the left, from the tonsil lobe to the hypopharyngeal entrance and supraglottic on the left including the aryepiglottic fold. The three-dimensional shape of the defect is measured. The radial flap is now elevated: Flap size is drawn in according to the three-dimensional requirements. The skin monitor is also drawn in. Then angle the arm and apply a tourniquet. Gradually develop the radial artery flap from subfascial, taking subcutaneous tissue with it, if necessary for the skin monitor. The radial artery is placed caudally and supplied proximally and distally using 4.0 Prolene puncture ligatures. Outgoing smaller vessels to the muscles are supplied with clips. Confluence of the radial vein, radial artery and cephalic artery can be exposed in the elbow area. A running cutaneous nerve can also be dissected and lifted along with the flap. After opening the tourniquet, good perfusion of the flap and the skin monitor. Deposition of the flap, whereby the outlet of the radial artery is treated with a 4.0 Prolene stitch. Veins are ligated. Flap vessels are flushed with heparin and placed in saline compresses. The flap is then sutured into the defect: Once the flap has been placed in the correct position, it is sutured successively using 3.0 Vicryl single-button sutures. Tension-free suturing with complete closure. Flap handle is passed through from left to right. The flap is connected in an end-to-end anastomosis between the radial artery and the superior thyroid artery using 9.0 Ethilon single-button sutures. After releasing the clamp, good perfusion and good venous return. The flap vein and facial vein are then conditioned. After measuring the vascular lumen, the anastomosis is performed without complications using a 3 mm vascular coupler. After opening the clamps, good reflux, positive smear phenomenon. Overall good perfusion of the flap. Co-prepared cutaneous nerve is now adapted on the left side to the stump of the superior laryngeal nerve, which had to be sacrificed during tumor resection, using several Ethilon 9.0 sutures to sensitize the radial lobe. Subsequent tracheostoma creation: splitting of the thyroid isthmus and coagulation. This is very thin and rudimentary. Visualization of the anterior tracheal wall. Entering the 2nd/3rd intercartilaginous space and creation of a broadly pedicled Björk flap. Epithelialization of this. Re-intubation and insertion of a 9 mm tracheal cannula. This is followed by irrigation of the wound area with H2O2 and Ringer's solution, as directly after the tumor resection, as well as at the end of the entire operation, and careful hemostasis. Insertion of a Redon drain into each side. Repositioning of the apron flap. Skin incision at the level of the skin monitor and insertion of the skin monitor. This is fixed in the skin without tension using subcutaneous sutures and skin sutures. The wound is then closed in layers in the area of the apron flap and the epithelialization of the tracheostoma. Full-thickness skin removal from the groin: Depending on the size of the defect, a piece of skin, approx. 8 x 6 cm, is harvested from the groin as a full-thickness skin graft. This is thinned out. In the groin area, after mobilization of the skin, the wound is closed in layers and a Redon drain is inserted with minimal tension. After thinning, the removed full-thickness skin is sutured into the area of the forearm defect without tension. The forearm is closed in layers. A sterile Vacuseal dressing is then applied, which works with a suction of 75 mmHg. The arm is then wrapped in a Kramer splint using an elastic bandage. Then mark the localization for vascular control with the Doppler. The cannula is fixed with tape. Completion of the procedure without complications. Patient received Unacid intraoperatively as an antibiotic. Please continue postoperatively for 1 week. Heparin at 500 units per hour, as started intraoperatively, continue for 5 days postoperatively. Feeding via the previously inserted PEG tube for approx. 10 days, then gruel swallow and swallowing attempt, if necessary diet build-up, but intensive swallowing training is certainly necessary here. Please contact the voice and speech department or speech therapist at an early stage. Overall cT2-3 cN2b oropharyngeal carcinoma on the left, postoperative RT or RCT to be discussed after histological findings. \ No newline at end of file diff --git a/216/InvasionFront_CD3_block19_x5_y6_patient216_0.json b/216/InvasionFront_CD3_block19_x5_y6_patient216_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4554548a7dc8840fde480214b4e494476b15e82d --- /dev/null +++ b/216/InvasionFront_CD3_block19_x5_y6_patient216_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16941.0, + "Centroid Y µm": 17665.6, + "Num Detections": 19992, + "Num Negative": 19429, + "Num Positive": 563, + "Positive %": 2.816, + "Num Positive per mm^2": 283.22 + } +} \ No newline at end of file diff --git a/216/InvasionFront_CD3_block19_x6_y6_patient216_1.json b/216/InvasionFront_CD3_block19_x6_y6_patient216_1.json new file mode 100644 index 0000000000000000000000000000000000000000..269ecbc5dc54b9971e0145602aa48fd94b8ac196 --- /dev/null +++ b/216/InvasionFront_CD3_block19_x6_y6_patient216_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19464.7, + "Centroid Y µm": 17890.5, + "Num Detections": 20424, + "Num Negative": 19765, + "Num Positive": 659, + "Positive %": 3.227, + "Num Positive per mm^2": 300.69 + } +} \ No newline at end of file diff --git a/216/InvasionFront_CD8_block19_x5_y6_patient216_0.json b/216/InvasionFront_CD8_block19_x5_y6_patient216_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee8274ab203c6f4750517ead8f916a3ae32f4708 --- /dev/null +++ b/216/InvasionFront_CD8_block19_x5_y6_patient216_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16741.1, + "Centroid Y µm": 25111.7, + "Num Detections": 14823, + "Num Negative": 14416, + "Num Positive": 407, + "Positive %": 2.746, + "Num Positive per mm^2": 225.5 + } +} \ No newline at end of file diff --git a/216/InvasionFront_CD8_block19_x6_y6_patient216_1.json b/216/InvasionFront_CD8_block19_x6_y6_patient216_1.json new file mode 100644 index 0000000000000000000000000000000000000000..49a2203b6c4ee01c02b88770349614f5fafd9be0 --- /dev/null +++ b/216/InvasionFront_CD8_block19_x6_y6_patient216_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19289.8, + "Centroid Y µm": 25236.6, + "Num Detections": 14453, + "Num Negative": 14045, + "Num Positive": 408, + "Positive %": 2.823, + "Num Positive per mm^2": 225.2 + } +} \ No newline at end of file diff --git a/216/TumorCenter_CD3_block19_x5_y6_patient216_0.json b/216/TumorCenter_CD3_block19_x5_y6_patient216_0.json new file mode 100644 index 0000000000000000000000000000000000000000..51a942ff3eb53ef6c669a9886b02b17949bce43d --- /dev/null +++ b/216/TumorCenter_CD3_block19_x5_y6_patient216_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17115.9, + "Centroid Y µm": 15441.8, + "Num Detections": 16409, + "Num Negative": 15122, + "Num Positive": 1287, + "Positive %": 7.843, + "Num Positive per mm^2": 556.61 + } +} \ No newline at end of file diff --git a/216/TumorCenter_CD3_block19_x6_y6_patient216_1.json b/216/TumorCenter_CD3_block19_x6_y6_patient216_1.json new file mode 100644 index 0000000000000000000000000000000000000000..50e30181fa92a051ba0ae2095f04511afc24a5c0 --- /dev/null +++ b/216/TumorCenter_CD3_block19_x6_y6_patient216_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19564.6, + "Centroid Y µm": 15167.0, + "Num Detections": 14013, + "Num Negative": 13098, + "Num Positive": 915, + "Positive %": 6.53, + "Num Positive per mm^2": 434.19 + } +} \ No newline at end of file diff --git a/216/TumorCenter_CD8_block19_x5_y6_patient216_0.json b/216/TumorCenter_CD8_block19_x5_y6_patient216_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6ab8b2bb944a995dc03f414da2d292adc4c558cf --- /dev/null +++ b/216/TumorCenter_CD8_block19_x5_y6_patient216_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 26036.2, + "Num Detections": 17191, + "Num Negative": 16777, + "Num Positive": 414, + "Positive %": 2.408, + "Num Positive per mm^2": 180.31 + } +} \ No newline at end of file diff --git a/216/TumorCenter_CD8_block19_x6_y6_patient216_1.json b/216/TumorCenter_CD8_block19_x6_y6_patient216_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fdedb8761b1fba29e9d602c5e9d87ab06d97ec25 --- /dev/null +++ b/216/TumorCenter_CD8_block19_x6_y6_patient216_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21438.6, + "Centroid Y µm": 26061.2, + "Num Detections": 14265, + "Num Negative": 13857, + "Num Positive": 408, + "Positive %": 2.86, + "Num Positive per mm^2": 197.5 + } +} \ No newline at end of file diff --git a/216/history_text.txt b/216/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/216/icd_codes.txt b/216/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8a5eff5f6f171b923e92fe5d964fb80737503ff8 --- /dev/null +++ b/216/icd_codes.txt @@ -0,0 +1 @@ +Carcinoma in situ der Epiglottis[D02.0 ] \ No newline at end of file diff --git a/216/ops_codes.txt b/216/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ed27ffddcceafdcde9401679927f47b724d6dbe --- /dev/null +++ b/216/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/216/patient_clinical_data.json b/216/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e3b100288c44270dd35fa9953184629b7213b1f9 --- /dev/null +++ b/216/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 41, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/216/patient_pathological_data.json b/216/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e8444e702a88ed1706b0aa17c99e35a8f259226b --- /dev/null +++ b/216/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "216", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": null, + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/216/surgery_description.txt b/216/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d93522d27e80d22d25be6537078f54cfd9a09538 --- /dev/null +++ b/216/surgery_description.txt @@ -0,0 +1 @@ +Laser resection of laryngeal epiglottic surface, Placement of nasogastric feeding tube diff --git a/216/surgery_report.txt b/216/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e4d69b7d262beca7b086999a43f026e5d497dbe5 --- /dev/null +++ b/216/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia and transoral endotracheal intubation using a laser tube by the anesthesia colleagues and positioning of the patient by the surgeon. Perform a laryngoscopy using a Kleinsasser C-tube. Inspection of the findings. This shows the exophytic mass on the left side of the laryngeal epiglottis area, reaching the midline. Setting the CO2 laser beam to a power of 6 watts in continuous mode. Cutting through the epiglottis in the midline. Successive traversing of the findings on the laryngeal epiglottis area on the left side. Repeatedly readjust the findings using the Kleinsasser C-tube. The findings can then be completely removed. Removal of 3 representative marginal samples (lateral, medial, caudal). All are found to be tumor-free by the pathology colleagues in the frozen section. Hemostasis using monopolar coagulation. Dry conditions. Good aspect. Placement of a nasogastric feeding tube. Completion of the procedure without complications. Please feed via the nasogastric feeding tube for the next 7 days and carefully build up the diet from the 8th postoperative day. \ No newline at end of file diff --git a/217/InvasionFront_CD3_block2_x5_y6_patient217_0.json b/217/InvasionFront_CD3_block2_x5_y6_patient217_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e7b908e7f55d0e659a0863d464a87d22b8dcdcb --- /dev/null +++ b/217/InvasionFront_CD3_block2_x5_y6_patient217_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 28584.9, + "Num Detections": 27379, + "Num Negative": 18691, + "Num Positive": 8688, + "Positive %": 31.73, + "Num Positive per mm^2": 3147.1 + } +} \ No newline at end of file diff --git a/217/InvasionFront_CD3_block2_x6_y6_patient217_1.json b/217/InvasionFront_CD3_block2_x6_y6_patient217_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1697d69696d2a7585052eab027e4220da65ee1ef --- /dev/null +++ b/217/InvasionFront_CD3_block2_x6_y6_patient217_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21413.7, + "Centroid Y µm": 28709.8, + "Num Detections": 22535, + "Num Negative": 16073, + "Num Positive": 6462, + "Positive %": 28.68, + "Num Positive per mm^2": 2712.8 + } +} \ No newline at end of file diff --git a/217/InvasionFront_CD8_block2_x5_y6_patient217_0.json b/217/InvasionFront_CD8_block2_x5_y6_patient217_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3ee944c755a359f97c06c4e2ad5470ecc44d803f --- /dev/null +++ b/217/InvasionFront_CD8_block2_x5_y6_patient217_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17540.7, + "Centroid Y µm": 16291.4, + "Num Detections": 27912, + "Num Negative": 20531, + "Num Positive": 7381, + "Positive %": 26.44, + "Num Positive per mm^2": 2693.6 + } +} \ No newline at end of file diff --git a/217/InvasionFront_CD8_block2_x6_y6_patient217_1.json b/217/InvasionFront_CD8_block2_x6_y6_patient217_1.json new file mode 100644 index 0000000000000000000000000000000000000000..50277e75ee4d63021c828cb2854b98b2b482be63 --- /dev/null +++ b/217/InvasionFront_CD8_block2_x6_y6_patient217_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20239.3, + "Centroid Y µm": 16416.3, + "Num Detections": 23841, + "Num Negative": 17011, + "Num Positive": 6830, + "Positive %": 28.65, + "Num Positive per mm^2": 2834.4 + } +} \ No newline at end of file diff --git a/217/TumorCenter_CD3_block2_x5_y6_patient217_0.json b/217/TumorCenter_CD3_block2_x5_y6_patient217_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be0631af66d0d51a10a392c92e8f7ea23e66eda0 --- /dev/null +++ b/217/TumorCenter_CD3_block2_x5_y6_patient217_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 14992.1, + "Num Detections": 20278, + "Num Negative": 13328, + "Num Positive": 6950, + "Positive %": 34.27, + "Num Positive per mm^2": 3246.0 + } +} \ No newline at end of file diff --git a/217/TumorCenter_CD3_block2_x6_y6_patient217_1.json b/217/TumorCenter_CD3_block2_x6_y6_patient217_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d21d44859efd858da6fe05286ea69a6705ca4ba5 --- /dev/null +++ b/217/TumorCenter_CD3_block2_x6_y6_patient217_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 15067.0, + "Num Detections": 17041, + "Num Negative": 9531, + "Num Positive": 7510, + "Positive %": 44.07, + "Num Positive per mm^2": 4034.4 + } +} \ No newline at end of file diff --git a/217/TumorCenter_CD8_block2_x5_y6_patient217_0.json b/217/TumorCenter_CD8_block2_x5_y6_patient217_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a2f4b365338ac2fa0f3a9f9544186c2e9c69924 --- /dev/null +++ b/217/TumorCenter_CD8_block2_x5_y6_patient217_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 14692.2, + "Num Detections": 25229, + "Num Negative": 19867, + "Num Positive": 5362, + "Positive %": 21.25, + "Num Positive per mm^2": 2132.2 + } +} \ No newline at end of file diff --git a/217/TumorCenter_CD8_block2_x6_y6_patient217_1.json b/217/TumorCenter_CD8_block2_x6_y6_patient217_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c00834d1e833d6fcab834490cd81d8af0d3b330f --- /dev/null +++ b/217/TumorCenter_CD8_block2_x6_y6_patient217_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20714.0, + "Centroid Y µm": 14592.3, + "Num Detections": 19873, + "Num Negative": 14269, + "Num Positive": 5604, + "Positive %": 28.2, + "Num Positive per mm^2": 2665.1 + } +} \ No newline at end of file diff --git a/217/history_text.txt b/217/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..277ea3c4c5a95c36ed7cff6a205e9843ca4d640e --- /dev/null +++ b/217/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Clinically and by imaging confirmed urgent suspicion of tonsillar carcinoma on the right with corresponding metastasis in the area of the right side of the neck. \ No newline at end of file diff --git a/217/icd_codes.txt b/217/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e6aed487201f57db651d4c3d5370d1e8411f4a75 --- /dev/null +++ b/217/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Gaumenbogentonsillen[C09.1 R] \ No newline at end of file diff --git a/217/ops_codes.txt b/217/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aefa544419d82abd45c0fe6dd1746684058872c6 --- /dev/null +++ b/217/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Transorale Tumortonsillektomie[5-281.2 ] \ No newline at end of file diff --git a/217/patient_clinical_data.json b/217/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..108f83c9b81d627951a247dbb793cee91359ed55 --- /dev/null +++ b/217/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/217/patient_pathological_data.json b/217/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f856677ad1810fa721783fea086cccaa16a8c34c --- /dev/null +++ b/217/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "217", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/217/surgery_description.txt b/217/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7751c7d394c35fb81d906da1e27ae4a3ef4f0dac --- /dev/null +++ b/217/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy and Panendoscopy diff --git a/217/surgery_report.txt b/217/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2362c1b05d5e12c7f3a93c9de64cc0826f3943db --- /dev/null +++ b/217/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Then advance the 0° optic through the glottic plane into the trachea. Inconspicuous mucosal conditions in the area of the trachea up to the exit of the segmental bronchi. Intubation of the patient. Then inspection of the hypopharynx on both sides, the postcricoid region and the oropharynx. In the area of the base of the tongue, the mucosal conditions are unremarkable, also in the area of the hypopharynx and the postcricoid region. In the area of the left tonsil, the mucosal conditions are unremarkable. The floor of the mouth is also completely normal on inspection and palpation. Inspection of the right tonsil. A tumorous mass is seen here, which completely covers the tonsil and also extends somewhat laterally. Then elevation of the soft palate. Inspection of the nasopharynx. Inconspicuous mucosal conditions here. Advance the flexible endoscope into the stomach. Careful mirroring back. Inconspicuous mucosal conditions in the area of the stomach and oesophagus. Adjustment with the tonsil retractor. Then incision of the right-sided tonsil, including the areas suspected of being tumorous. Dissection laterally into the pharyngeal musculature. Careful dissection of the tumor. As far as can be assessed intraoperatively, the tumor can be completely removed. Removal of the tumor in the area of the posterior palatal arch and in the area of the base of the tongue. Careful hemostasis. Removal of several marginal samples. Clinically, the resection is performed safely in healthy tissue. If conditions are dry overall, the procedure is now completed. Final consultation with the anesthetist. Transfer of the patient to the recovery ward. \ No newline at end of file diff --git a/218/InvasionFront_CD3_block13_x1_y1_patient218_0.json b/218/InvasionFront_CD3_block13_x1_y1_patient218_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c89941041e778733c9f9ceb2ac90eed5b4582f7a --- /dev/null +++ b/218/InvasionFront_CD3_block13_x1_y1_patient218_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3748.0, + "Centroid Y µm": 2323.8, + "Num Detections": 17765, + "Num Negative": 17123, + "Num Positive": 642, + "Positive %": 3.614, + "Num Positive per mm^2": 290.52 + } +} \ No newline at end of file diff --git a/218/InvasionFront_CD3_block13_x2_y1_patient218_1.json b/218/InvasionFront_CD3_block13_x2_y1_patient218_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f79bb3092f028c26ca30f669db7c4370f60713fd --- /dev/null +++ b/218/InvasionFront_CD3_block13_x2_y1_patient218_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 2173.8, + "Num Detections": 17798, + "Num Negative": 17440, + "Num Positive": 358, + "Positive %": 2.011, + "Num Positive per mm^2": 162.68 + } +} \ No newline at end of file diff --git a/218/InvasionFront_CD8_block13_x1_y1_patient218_0.json b/218/InvasionFront_CD8_block13_x1_y1_patient218_0.json new file mode 100644 index 0000000000000000000000000000000000000000..112dd46105541dc8a70d2ce7366a1989d25c0bc0 --- /dev/null +++ b/218/InvasionFront_CD8_block13_x1_y1_patient218_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5497.1, + "Centroid Y µm": 3198.3, + "Num Detections": 22024, + "Num Negative": 21754, + "Num Positive": 270, + "Positive %": 1.226, + "Num Positive per mm^2": 114.34 + } +} \ No newline at end of file diff --git a/218/InvasionFront_CD8_block13_x2_y1_patient218_1.json b/218/InvasionFront_CD8_block13_x2_y1_patient218_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2717c0818ada847303116da292b3d816905d250b --- /dev/null +++ b/218/InvasionFront_CD8_block13_x2_y1_patient218_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8095.7, + "Centroid Y µm": 3348.2, + "Num Detections": 20532, + "Num Negative": 20270, + "Num Positive": 262, + "Positive %": 1.276, + "Num Positive per mm^2": 109.33 + } +} \ No newline at end of file diff --git a/218/TumorCenter_CD3_block13_x1_y1_patient218_0.json b/218/TumorCenter_CD3_block13_x1_y1_patient218_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7b51ae9c1cdcae57e67824bab157526acf7709ff --- /dev/null +++ b/218/TumorCenter_CD3_block13_x1_y1_patient218_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5747.0, + "Centroid Y µm": 8395.6, + "Num Detections": 14028, + "Num Negative": 13269, + "Num Positive": 759, + "Positive %": 5.411, + "Num Positive per mm^2": 497.07 + } +} \ No newline at end of file diff --git a/218/TumorCenter_CD3_block13_x2_y1_patient218_1.json b/218/TumorCenter_CD3_block13_x2_y1_patient218_1.json new file mode 100644 index 0000000000000000000000000000000000000000..76fb79e93db12e2357af295b2f2c5fd8eb5cb5b4 --- /dev/null +++ b/218/TumorCenter_CD3_block13_x2_y1_patient218_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8420.5, + "Centroid Y µm": 8645.4, + "Num Detections": 21510, + "Num Negative": 20241, + "Num Positive": 1269, + "Positive %": 5.9, + "Num Positive per mm^2": 526.39 + } +} \ No newline at end of file diff --git a/218/TumorCenter_CD8_block13_x1_y1_patient218_0.json b/218/TumorCenter_CD8_block13_x1_y1_patient218_0.json new file mode 100644 index 0000000000000000000000000000000000000000..064d24c0f455d71cd782bb94827390f3faaddd7a --- /dev/null +++ b/218/TumorCenter_CD8_block13_x1_y1_patient218_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 2973.4, + "Centroid Y µm": 3897.9, + "Num Detections": 16788, + "Num Negative": 16716, + "Num Positive": 72, + "Positive %": 0.4289, + "Num Positive per mm^2": 38.74 + } +} \ No newline at end of file diff --git a/218/TumorCenter_CD8_block13_x2_y1_patient218_1.json b/218/TumorCenter_CD8_block13_x2_y1_patient218_1.json new file mode 100644 index 0000000000000000000000000000000000000000..775c189baec2123cdc8c88438cbc5675b4db2a60 --- /dev/null +++ b/218/TumorCenter_CD8_block13_x2_y1_patient218_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5597.0, + "Centroid Y µm": 3623.1, + "Num Detections": 22641, + "Num Negative": 22577, + "Num Positive": 64, + "Positive %": 0.2827, + "Num Positive per mm^2": 25.89 + } +} \ No newline at end of file diff --git a/218/history_text.txt b/218/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..50d802111fccacdfba709dddecb1de2ade4e7811 --- /dev/null +++ b/218/history_text.txt @@ -0,0 +1 @@ +The patient has an extensive right hypopharyngeal/laryngeal carcinoma with a lymph node metastasis infiltrating the jugular vein and the sternocleidomastoid muscle on the right side. Due to the patient's poor general condition, primary radiochemotherapy is not an option, therefore the above-mentioned operation is indicated. \ No newline at end of file diff --git a/218/icd_codes.txt b/218/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f552feb24f34da0f2b9980df2a057f4ee2121da --- /dev/null +++ b/218/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/218/ops_codes.txt b/218/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..51debd71fb406b19101f33f541643aaac637db10 --- /dev/null +++ b/218/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Entnahme von Spalthaut am Oberschenkel[5-901.0e R] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] Wechsel vaskuläres Implantat[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] \ No newline at end of file diff --git a/218/patient_clinical_data.json b/218/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e3ac8bb67263af45dcada724acf954bc1d208ed1 --- /dev/null +++ b/218/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 55, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/218/patient_pathological_data.json b/218/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b9fa9f9e0440292f82a5336ef3a2c250a7ab64d3 --- /dev/null +++ b/218/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "218", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/218/surgery_description.txt b/218/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..203c0b787a3599edb267db59feb4f0eadbb5b1d3 --- /dev/null +++ b/218/surgery_description.txt @@ -0,0 +1 @@ +Complete pharyngectomy and laryngectomy diff --git a/218/surgery_report.txt b/218/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f90741b409d97a8ff8ab4c8919b4b9b1b47ebab --- /dev/null +++ b/218/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation via the patient's existing tracheostoma, the operation is first planned during pharyngoscopy. This reveals a right-sided, exophytic tumor, which extends in the area of the oropharyngeal side wall to the tonsil and then affects the pharyngoepiglottic fold, involves the entire right piriform sinus and also clearly affects the postcricoid region in the area of the right side, almost completely encloses the lateral piriform sinus laterally, but only slightly affects the posterior pharyngeal wall posteriorly. In the larynx, the epiglottis is partially affected, the right aryepiglottic fold, the right arytenoid cartilage and the pocket folds are completely affected. The tumor grows over the interarytenoid region into the postcricoid region. The left arytenoid cartilage and the left aryepiglottic fold are tumor-free, as are the vallecula and more than half of the epiglottis. Deep down, the left piriform sinus is completely free, but the entrance to the esophagus is stenosed and it is not possible to determine exactly to what extent the entrance to the esophagus is affected, but this can be assumed based on the fixation. Discussion of findings with and procedure for surgery. First, formation of an apron flap, which extends from the tracheostoma to the far lateral side. Then create the apron flap, partly with the help of the BiClamp system. Expose the sternocleidomastoid muscle on both sides and form the apron flap up to above the hyoid bone. Now turn to the neck dissection of the right side. The very prominent, partially fixed lump can be easily palpated here. An attempt is first made to dissect the sternocleidomastoid muscle and the internal jugular vein, but it quickly becomes apparent that they are completely infiltrated by the tumor. The decision is now made to perform a radical neck dissection. The posterior digastric venter muscle and the submandibular gland are exposed and isolated. The sternocleidomastoid muscle is then imaged in the cranial region. The accessorius nerve can also be identified here and initially spared. The sternocleidomastoid muscle is then resected in its caudal area and the same is done in its cranial area, taking care to spare the part of the accessorius nerve that goes towards the trapezius muscle. Now continue to form the lateral border of the neck. Deep exposure of the plexus branches and the scalene muscles in their lateral area. Then complete visualization of the internal jugular vein in its caudal and cranial course. Identify the hypoglossal nerve and spare the last one. The internal jugular vein is now ligated twice and separated cranially and caudally. Prior to this, the common carotid artery and the vagus nerve were identified and spared. In addition to the large tumor, which appears to be fixed towards the thyroid cartilage, there are also additional tumor conglomerates in level IIa. Now turn to the medial neck preparation. To do this, follow the omohyoid muscle anteriorly and the digastric muscle anteriorly. Then form the medial neck preparation along the thyroid cartilage muscles. This reveals a site between the thyroid cartilage and the hyoid bone where the tumor conglomerate is connected to the actual tumor per continuitatem. This site is cut and marked on both the thyroid cartilage and the tumor. The medial neck preparation is then followed up, sparing the hypoglossal nerve. Exposure of the superior thyroid artery, which is clamped. Then expose the carotid artery from caudal to cranial and also the vagus nerve from caudal to cranial. Now turn again to level II b and here further development of the lateral neck preparation from cranial to caudal while sparing the plexus branches. At the end, the entire neck preparation is formed in a large block. Now turn to the neck dissection of the left side. No large lymph node metastases are visible here, therefore expose the sternocleidomastoid muscle. Formation of the anterior border and visualization of the posterior digastric venter muscle and the omohyoid muscle. Identify the accessorius nerve and then form the internal jugular vein from caudal to cranial. Here, after identifying and sparing the vagus nerve, the lateral neck preparation is formed while sparing the accessorius nerve and plexus branches. Then turn to the medial neck preparation. Trace the omohyoid muscle, trace the digastric muscle anteriorly and expose and skeletonize the submandibular gland and spare the facial vein. After identifying the hypoglossal nerve, the medial neck preparation is also formed, whereby the superior thyroid artery is also spared. Preparation for laryngectomy/partial pharyngectomy. Preparation of the tracheostoma. Exposure of the right thyroid gland from the trachea while protecting the blood supply. Then expose the cervical vascular sheath on the left side from the laryngeal preparation down to the vertebral body. Further cranial ligation of the bundle of the superior laryngeal nerve and skeletonization in the upper area with monopolar coagulation of the hyoid bone. Now the constrictor pharyngeal muscle on the left side of the thyroid cartilage is also cut with the monopolar and the upper thyroid cartilage horn is exposed. Then, with the help of the Freer raspatory, expose the piriform sinus from the inner side of the thyroid cartilage. Now turn to the right side. As described above, this shows a tumor breakthrough between the thyroid cartilage and hyoid bone, which is why the constrictor pharyngis muscle is not exposed here. Only the carotid artery is exposed from the laryngeal preparation. It can also be seen that the right lobe of the thyroid gland is severely regressively altered with cystic areas and a fixation to the tumor. For this reason, the right thyroid lobe is also isolated from the surrounding tissue, with the inferior thyroid artery and the middle thyroid vein ligated and ligated. The right thyroid lobe thus remains on the subsequent tumor specimen. Now, after previously skeletonizing the hyoid bone, the transoral localization of the epiglottis and the submucosal dissection along the left lingual epiglottis cartilage is performed through the neck. The pharynx is then opened on the left side and initially dissected along the left aryepiglottic fold. It can be seen that the tumor clearly involves the oropharynx on the right side, as already described above. The entire right hypopharynx is full of exophytic tumor. The resection is now extended to the right via the right base of the tongue, then to the right tonsil. Previously, the internal carotid artery was traced far to the cranial side in order to isolate it from the pharynx and the lingual artery was ligated and cut. The resection is now extended to the left via the aryepiglottic fold to the left arytenoid cartilage. However, the postcricoid region is affected up to the midline and cannot be preserved. An attempt is made to preserve the left piriform sinus, but it is suspected that the tumor is also growing submucosally through the thyroid cartilage to the left piriform sinus. A frozen section sample is therefore taken here, which is later found to contain tumor. The resection now continues caudally. On the right side, a good part of the posterior pharyngeal wall is resected, on the left side a little of the postcricoid region can be spared. The esophageal entrance is now reached. It can be seen here that the tumor infiltrates the esophageal entrance on its anterior and right side. The specimen is removed here and a marginal sample is also taken, which is later found to be tumor-infested. Another problem area is the base of the tongue, which is also infiltrated at certain points and, after consultation with , it is suspected that infiltrated regions repeatedly appear between the base of the tongue and the esophageal opening on the right side. Therefore, after careful assessment of the situation, decided to perform a complete pharyngectomy and also a resection in the area of the esophageal inlet. Prior to this, part of the base of the tongue is resected and a frozen section is performed again, which is later found to be tumor-free. This is followed by pharyngectomy and a myotomy of the upper esophageal sphincter in the caudal region and a resection in the anterior and right-accentuated region. All frozen sections are later found to be tumor-free. Radial flap elevation and the formation of a complete pharyngeal replacement are now performed, which is dictated separately by . The resulting defect in the area of the left forearm is approximately 10 x 15 cm long and is removed with 2 strips of split skin, 0.7 mm thick, from the area of the right thigh and then painstakingly sutured in place. Finally, the Mepilex insert is applied to both regions, the thigh and the forearm, and the forearm is bandaged with a splint. Dictation Patient with histologically confirmed incontinuitous growing cT4a laryngeal carcinoma on the right. Therefore above mentioned surgical indication. Flap coverage included in the surgical planning preoperatively. After completion of the pharyngectomy, the marginal specimens in the tongue base area and the circular marginal specimen in the esophageal entrance area were finally free of carcinoma. The circular pharynx must now be replaced. Now remove the radial lobe: mark a flap 9 or 10.5 cm wide and 15 cm long on the left forearm. Also mark a skin monitor island. Successive cutting around the flap at the marked borders subfascially, the flap is finally lifted from all sides. Lifting is performed with the skin monitor including the superficial venous system. Exposure of the vascular pedicle after dissection of the brachioradialis muscle. Finally, distal placement of the flap on the radial artery and vein. Here, 4-0 prolene puncture ligation is performed on both sides. Successive lifting of the flap along its pedicle, taking the superficial venous system and the skin monitor with it. Outgoing vessels are successively clipped or bipolized. Exposure of the deep and superficial vascular pedicle in the crook of the elbow. The radial artery is placed in front of the interosseous artery and sutured over. Finally, the cephalic vein and a further medially larger outgoing vein are removed in the direction of the basilar vein. The superficial and deep venous systems are connected and have an outflow via these two veins. The most careful hemostasis was performed in the area of the flap before the vessels were removed. Subsequently, careful hemostasis was also performed in the area of the forearm. Successive closure of the forearm, primarily in the cranial area. Depending on the skin defect, 0.7 mm thick split skin is now removed using the dermatome. This is successively sutured into the forearm skin defect. Complete tension-free coverage of the skin defect on the forearm. A hydrocolloid lavanide-Mepilex dressing is then applied. Loosely placed swabs are placed over this. Wrap the forearm in absorbent cotton. Wrap an elastic bandage around the splint. The arm is then inserted. This is followed by the total pharyngeal set using the radial flap: successive suturing of the flap, initially caudally with 4-0 Vicryl single button sutures, paying strict attention to sufficient residual lumen thickness at the neopharyngo-oesophagial junction. Passage is finally easy to pass with the finger. The esophageal entrance is plastically widened in the sense of a continuous myotomy with mucosal transection. The appropriately shaped radial flap is now sutured into the incision. Successive suturing of the flap also from the cranial side with Vicryl 3-0 single button sutures, whereby a tension-free closure is achieved at the junction of the base of the tongue or tonsil lobe and radialis flap. Laterally, the radial lobe is sutured to itself. Over-sewing in the lateral area and also caudally and cranially at the transition to the base of the tongue in a second layer. The vessels on the sides of the neck are then conditioned. The left side of the neck is selected. The superior thyroid artery is selected. After conditioning the arteries, the radial artery is sutured end-to-end with the superior thyroid artery using 8-0 Ethilon single-button sutures. After opening the clamp, good arterial flow and good venous return. This is followed by 2 venous anastomoses between the main outlets and the facial vein. After conditioning the vein, the smaller vein is first anastomosed using a 2/5 coupler and finally the larger vein is anastomosed using a 3/0 coupler. In each case, after opening the clamps, good venous return, positive smear phenomenon. At the end, good venous return, positive smear phenomenon. The pedicle is now placed in such a way that kinking of the vessels is largely prevented. For this purpose, the skin monitor is placed in the middle over the flap. This is followed by extensive hemostasis of the entire wound area on both sides. Redon drainage on both sides. Repositioning of the apron flap. This is opened medially and the skin monitor is sutured in place without tension. Subsequent successive closure of the neck wounds in layers with epithelialization of the tracheostoma. Finally, insertion of a 10 mm tracheostomy tube which is fixed with sutures. Postoperatively, the patient is ventilated and admitted to the intensive care unit. Please continue intraoperative antibiotic treatment with Unacid for 1 week. Please continue heparin perfusor with 500 E/hour for 5 days. Feeding via PEG tube for 10-12 days, then gruel and, if necessary, diet build-up. Check the flap clinically on the skin monitor and by Doppler according to the scheme for 5 days. Overall, cT4a cN2c hypopharyngeal carcinoma with invasion into the larynx and continuous growth into the soft tissues of the neck. Postoperative RCT is certainly indicated, but this should be discussed again in the interdisciplinary tumor conference in view of the concomitant diseases. \ No newline at end of file diff --git a/219/InvasionFront_CD3_block6_x5_y10_patient219_0.json b/219/InvasionFront_CD3_block6_x5_y10_patient219_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f450f6577d9e3988bf73ce17875ba0601e6e15e2 --- /dev/null +++ b/219/InvasionFront_CD3_block6_x5_y10_patient219_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 26286.1, + "Num Detections": 15110, + "Num Negative": 14539, + "Num Positive": 571, + "Positive %": 3.779, + "Num Positive per mm^2": 314.8 + } +} \ No newline at end of file diff --git a/219/InvasionFront_CD3_block6_x6_y10_patient219_1.json b/219/InvasionFront_CD3_block6_x6_y10_patient219_1.json new file mode 100644 index 0000000000000000000000000000000000000000..85dd1c944dbd56bee0628f0136578315ee814d31 --- /dev/null +++ b/219/InvasionFront_CD3_block6_x6_y10_patient219_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19289.8, + "Centroid Y µm": 26461.0, + "Num Detections": 15544, + "Num Negative": 15186, + "Num Positive": 358, + "Positive %": 2.303, + "Num Positive per mm^2": 169.75 + } +} \ No newline at end of file diff --git a/219/InvasionFront_CD8_block6_x5_y8_patient219_0.json b/219/InvasionFront_CD8_block6_x5_y8_patient219_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f195d8e6c96575a04f15c46b8dea1a4f1cc52d87 --- /dev/null +++ b/219/InvasionFront_CD8_block6_x5_y8_patient219_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17041.0, + "Centroid Y µm": 20464.2, + "Num Detections": 27942, + "Num Negative": 27480, + "Num Positive": 462, + "Positive %": 1.653, + "Num Positive per mm^2": 174.48 + } +} \ No newline at end of file diff --git a/219/InvasionFront_CD8_block6_x6_y8_patient219_1.json b/219/InvasionFront_CD8_block6_x6_y8_patient219_1.json new file mode 100644 index 0000000000000000000000000000000000000000..efe697a173943bd05dc050b2272cfb7501b1c70a --- /dev/null +++ b/219/InvasionFront_CD8_block6_x6_y8_patient219_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19614.6, + "Centroid Y µm": 20589.1, + "Num Detections": 20613, + "Num Negative": 19973, + "Num Positive": 640, + "Positive %": 3.105, + "Num Positive per mm^2": 294.95 + } +} \ No newline at end of file diff --git a/219/TumorCenter_CD3_block6_x5_y8_patient219_0.json b/219/TumorCenter_CD3_block6_x5_y8_patient219_0.json new file mode 100644 index 0000000000000000000000000000000000000000..091718bdb7a51897412d010b6be8d7fcf3498cab --- /dev/null +++ b/219/TumorCenter_CD3_block6_x5_y8_patient219_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 20289.3, + "Num Detections": 15478, + "Num Negative": 7437, + "Num Positive": 8041, + "Positive %": 51.95, + "Num Positive per mm^2": 4271.1 + } +} \ No newline at end of file diff --git a/219/TumorCenter_CD3_block6_x6_y8_patient219_1.json b/219/TumorCenter_CD3_block6_x6_y8_patient219_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a1069630cd1051767785898d16548ad429082d8f --- /dev/null +++ b/219/TumorCenter_CD3_block6_x6_y8_patient219_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 20189.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/219/TumorCenter_CD8_block6_x5_y8_patient219_0.json b/219/TumorCenter_CD8_block6_x5_y8_patient219_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08cb4f543a1c8a39af6be801026594f5bebef62a --- /dev/null +++ b/219/TumorCenter_CD8_block6_x5_y8_patient219_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 20639.1, + "Num Detections": 30510, + "Num Negative": 26850, + "Num Positive": 3660, + "Positive %": 12.0, + "Num Positive per mm^2": 1441.4 + } +} \ No newline at end of file diff --git a/219/TumorCenter_CD8_block6_x6_y8_patient219_1.json b/219/TumorCenter_CD8_block6_x6_y8_patient219_1.json new file mode 100644 index 0000000000000000000000000000000000000000..039b1d9f5c865d818a0faf0c87d081b5ee272c52 --- /dev/null +++ b/219/TumorCenter_CD8_block6_x6_y8_patient219_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 20464.2, + "Num Detections": 24712, + "Num Negative": 20825, + "Num Positive": 3887, + "Positive %": 15.73, + "Num Positive per mm^2": 1738.3 + } +} \ No newline at end of file diff --git a/219/history_text.txt b/219/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/219/icd_codes.txt b/219/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/219/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/219/ops_codes.txt b/219/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..860cfaedbd2f3e8070231f41d4432d58ac22f39b --- /dev/null +++ b/219/ops_codes.txt @@ -0,0 +1 @@ +mikrovaskulär-anastomosierten Transplantat[5-296.24 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheostomaanlage[5-312.0 ] Entnahme von Spalthaut des Unterarmes[5-901.08 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] \ No newline at end of file diff --git a/219/patient_clinical_data.json b/219/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5ece29c7cb8baed8abfd158f97e69a9ccfae7b10 --- /dev/null +++ b/219/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/219/patient_pathological_data.json b/219/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..36258a39d8522f17c45420fb20849cc62c5de16e --- /dev/null +++ b/219/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "219", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/219/surgery_description.txt b/219/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e4edc77ca1f21bfa3416fecd07c944affb8fe24a --- /dev/null +++ b/219/surgery_description.txt @@ -0,0 +1 @@ +Resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheotomy, PEG placement diff --git a/219/surgery_report.txt b/219/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..55f5bec39a375bfd25910cca01c990a7d8237db5 --- /dev/null +++ b/219/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, the tracheostoma is first created after opening the trachea between the 2nd and 3rd tracheal body. Creation of the mucocutaneous anastomosis and reintubation of the patient. PEG placement by /: Advancement of the gastroesophagoscope under constant air insufflation, spontaneous diaphanoscopy. Insertion of a PEG using the thread pull-through method in the typical manner, no complications. Then simultaneous start of elevation of the radial artery graft by and . Marking of the radial artery, palpatory identification of the distal radial artery and the ulnar artery. Marking of the flap borders (9 x 5.5 cm) on the distal forearm proximal to the flexor retinaculum with an S-shaped incision extending proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue from the proximal side. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the graft margin. Identification of the external ramus, the superficial ramus, the radial nerve, protection of these. Exposure of the vascular pedicle between the flexor carpi radialis muscle and brachioradialis muscle, here dissection of the pedicle without damaging the vessel to be anastomosed. The incision is now made along the flap borders on the distal forearm. Elevation of the radial portion while leaving the fascia of the brachioradialis tendon intact. Subsequent dissection down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the forearm fascia of the graft edge up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendinous tissue on the flexor tendon and to protect the ulnar artery. Identification of the artery. Clamp the radial artery with a vascular clamp. After 5 minutes under good pulsoxymetric oxygen saturation measured on the thumb (approx. 98%), the vessels are removed with subsequent ligation with silk thread after the flap umbrella has already been completely detached from the support. Perforators were treated with a vessel clip. Bipolar coagulation. The radial nerve in the median side of the brachioradialis muscle remains intact. The brachial artery was exposed as well as the recurrent radial artery, ulnar artery, radial artery and interosseous artery; the radial artery was removed while preserving all of the above vessels and ligated using a silk thread. Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm and defect coverage of the graft with split skin from the right thigh in a typical manner with stitching of the split skin. Application of a wound dressing, forearm splint, completion of graft elevation without complications. This is followed by transoral tumor resection. The resection includes the anterior palatal arch and the lower 2/3 of the tonsil bed. It extends laterally up to the mandible and passes ventrally into the lateral base of the tongue and the base of the tongue to then extend over the adjacent hypopharynx and then also over the posterior wall of the hypopharynx. The submandibular gland is reached and visualized in depth. The specimen is marked and oriented accordingly on a cork plate before being sent in. In the frozen section histological examination, parts of CIS can still be found in the area of the posterior hypopharyngeal wall as well as in the area of the lateral resection margin in the area of the mandible/ transition to the palatal arch. Corresponding resections are performed here, which are then found to be tumor-free by frozen section histology. Overall, a defect of about 10 x 5 cm is created. The radial artery flap to be removed from the left forearm is the same size. Transition first to neck dissection on the left side. Here, regions I to V are removed while preserving all non-lymphatic structures. The tendon of the digastric muscle is then severed. Dissection of the superior thyroid artery first, which, however, proves to be of small caliber. The lingual and facial arteries are then dissected. Finally, the facial artery is removed from the mandible and beaten downwards and later used for anastomosis. Then create a passage into the oral cavity above the digastric muscle. Perform selective neck dissection of regions II to IV on the right side while preserving all lymphatic structures. There is no clinical evidence of lymph node metastasis on either side. After lifting the radial lobe graft, it is swung into the defect and sutured into the defect both transorally and transcervically. The facial artery is then anastomosed to the radial artery. Venous drainage is achieved through 2 veins at the end of the lateral anastomosis to the internal jugular vein. After completion of Redon wound drainage on both sides, the wound is closed in several layers. Finally, the patient is intubated with an 8-gauge tracheostomy tube. End of the operation, transfer of the patient to anesthesia. Conclusion: Transoral tumor resection of a tumor in the area of the glossotonsillar groove with defect coverage using a free radial flap graft from the left forearm, neck dissection on both sides, tracheostoma placement. \ No newline at end of file diff --git a/220/InvasionFront_CD3_block15_x1_y1_patient220_0.json b/220/InvasionFront_CD3_block15_x1_y1_patient220_0.json new file mode 100644 index 0000000000000000000000000000000000000000..587b0e497c9d5384e3f9d81db0901320b6dae492 --- /dev/null +++ b/220/InvasionFront_CD3_block15_x1_y1_patient220_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5147.3, + "Centroid Y µm": 13168.0, + "Num Detections": 18137, + "Num Negative": 16790, + "Num Positive": 1347, + "Positive %": 7.427, + "Num Positive per mm^2": 562.2 + } +} \ No newline at end of file diff --git a/220/InvasionFront_CD3_block15_x2_y1_patient220_1.json b/220/InvasionFront_CD3_block15_x2_y1_patient220_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3a4d30b0ae9cca7caf101630aee8174738a990c6 --- /dev/null +++ b/220/InvasionFront_CD3_block15_x2_y1_patient220_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7745.9, + "Centroid Y µm": 13018.1, + "Num Detections": 19019, + "Num Negative": 17889, + "Num Positive": 1130, + "Positive %": 5.941, + "Num Positive per mm^2": 478.4 + } +} \ No newline at end of file diff --git a/220/InvasionFront_CD8_block15_x1_y1_patient220_0.json b/220/InvasionFront_CD8_block15_x1_y1_patient220_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0fcb5e7d6548c5fc812196d57b4724a8b6027aa2 --- /dev/null +++ b/220/InvasionFront_CD8_block15_x1_y1_patient220_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3708.3, + "Centroid Y µm": 2645.6, + "Num Detections": 13630, + "Num Negative": 12477, + "Num Positive": 1153, + "Positive %": 8.459, + "Num Positive per mm^2": 586.56 + } +} \ No newline at end of file diff --git a/220/InvasionFront_CD8_block15_x2_y1_patient220_1.json b/220/InvasionFront_CD8_block15_x2_y1_patient220_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8b1e2aec8ef6b692e27c7d095c6cc7b180964160 --- /dev/null +++ b/220/InvasionFront_CD8_block15_x2_y1_patient220_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6272.8, + "Centroid Y µm": 2602.0, + "Num Detections": 16787, + "Num Negative": 14535, + "Num Positive": 2252, + "Positive %": 13.42, + "Num Positive per mm^2": 1002.3 + } +} \ No newline at end of file diff --git a/220/TumorCenter_CD3_block15_x1_y1_patient220_0.json b/220/TumorCenter_CD3_block15_x1_y1_patient220_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3e6f9cc830ef5f9ee47d587881f30f61ac3e39fb --- /dev/null +++ b/220/TumorCenter_CD3_block15_x1_y1_patient220_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 5996.8, + "Num Detections": 14739, + "Num Negative": 14259, + "Num Positive": 480, + "Positive %": 3.257, + "Num Positive per mm^2": 226.65 + } +} \ No newline at end of file diff --git a/220/TumorCenter_CD3_block15_x2_y1_patient220_1.json b/220/TumorCenter_CD3_block15_x2_y1_patient220_1.json new file mode 100644 index 0000000000000000000000000000000000000000..56d50df1a4a0f4a6d60ebe33913de8e72f0fc6fc --- /dev/null +++ b/220/TumorCenter_CD3_block15_x2_y1_patient220_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 6021.8, + "Num Detections": 16822, + "Num Negative": 16244, + "Num Positive": 578, + "Positive %": 3.436, + "Num Positive per mm^2": 238.68 + } +} \ No newline at end of file diff --git a/220/TumorCenter_CD8_block15_x1_y1_patient220_0.json b/220/TumorCenter_CD8_block15_x1_y1_patient220_0.json new file mode 100644 index 0000000000000000000000000000000000000000..98688ee92f9a9633f444a57115a6daf508a1f552 --- /dev/null +++ b/220/TumorCenter_CD8_block15_x1_y1_patient220_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6483.5, + "Centroid Y µm": 2772.1, + "Num Detections": 15313, + "Num Negative": 14548, + "Num Positive": 765, + "Positive %": 4.996, + "Num Positive per mm^2": 318.39 + } +} \ No newline at end of file diff --git a/220/TumorCenter_CD8_block15_x2_y1_patient220_1.json b/220/TumorCenter_CD8_block15_x2_y1_patient220_1.json new file mode 100644 index 0000000000000000000000000000000000000000..165521892e847cffde18499f7591b8f0cfdaa0c4 --- /dev/null +++ b/220/TumorCenter_CD8_block15_x2_y1_patient220_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8945.3, + "Centroid Y µm": 2679.8, + "Num Detections": 18287, + "Num Negative": 17171, + "Num Positive": 1116, + "Positive %": 6.103, + "Num Positive per mm^2": 464.77 + } +} \ No newline at end of file diff --git a/220/history_text.txt b/220/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa620e6f7076163db8dfa959f26cd38ccb08fe17 --- /dev/null +++ b/220/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed squamous cell carcinoma G2 on the right edge of the tongue with a palpatory extension of approx. 2 x 1 cm. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/220/icd_codes.txt b/220/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ff2082a0115c5d5aa669e34936cf7d1a67d017e9 --- /dev/null +++ b/220/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 R] \ No newline at end of file diff --git a/220/ops_codes.txt b/220/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1d2d8c666641a58a397f0acf488f326d2b82acf0 --- /dev/null +++ b/220/ops_codes.txt @@ -0,0 +1 @@ +Zungentumorexzision[5-250.2 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagogastroskopie: Bei normalem Situs[1-631.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/220/patient_clinical_data.json b/220/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7976ce07479cbd6469237dbcb58835a5d90b2a25 --- /dev/null +++ b/220/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 84, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 6, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/220/patient_pathological_data.json b/220/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..847dd848fcbe022728211cf807d16fb28d123b8d --- /dev/null +++ b/220/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "220", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/220/surgery_description.txt b/220/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b12697a9fbf2d5d63d8365ff994142b56ee1bfb --- /dev/null +++ b/220/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection diff --git a/220/surgery_report.txt b/220/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..54f27861107691dceaab5cbae5be048b829f585e --- /dev/null +++ b/220/surgery_report.txt @@ -0,0 +1 @@ +Anesthesia is first induced by the anesthesia colleagues. Problem-free tracheoscopy by the surgeon. Inconspicuous conditions up to the caudal carina. Intubation by the anesthesia colleagues. Positioning of the patient for tumor resection. Suturing of the tongue after insertion of the Jennings mouth retractor. Repeated palpation of the tumor on the right edge of the tongue at mid-height. The tumor is centrally ulcerated and has leukoplakic changes around the crater. Palpatory size approx. 2 x 1 cm extending into the tongue musculature. Now mark the resectate borders around the tumor using monopolar coagulation. Tumor excision with the electric needle. Multiple hemostasis. A branch of the lingual artery is cut off. The lingual nerve is visible anteriorly, but can be spared. The Wharton's duct is not opened. Subsequent suture marking of the tumor, anterior short-short, tongue surface long-long and underside of tongue/bottom of mouth short-long. Removal of marginal samples. Starting with the mucosal circumference. Superficial marginal sample starting anteriorly with a width of approx. 3 mm and extending posteriorly to the floor of the mouth. Suture mark anteriorly. Border sample oral floor mucosa again from anterior to posterior, suture marking also anterior. Subsequently, take another marginal sample from the wound bed, once anteriorly and once posteriorly. All edge samples are tumor-free in the frozen section. In the meantime, perform panendoscopy. First perform esophagogastroscopy. Here the gastric mucosa is completely unremarkable. In the proximal third of the esophagus, the mucosa is slightly uneven and bumpy, but not suspicious. MLE is then performed. Inconspicuous conditions in the hypopharynx and larynx area. Easy insertion of a nasogastric tube via the right nostril. After receiving the frozen section, the wound edges are adapted using 3.0 Vicryl SH after consultation with . Subtle hemostasis is performed beforehand. Carbostesin is injected into the wound edge for postoperative analgesia. For swelling prophylaxis, administration of 250 mg cortisone, administration of antibiotic prophylaxis 3 g Unacid. \ No newline at end of file diff --git a/221/InvasionFront_CD3_block7_x5_y7_patient221_0.json b/221/InvasionFront_CD3_block7_x5_y7_patient221_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5800dd95cc012503d4bc2c247530abc31a26804c --- /dev/null +++ b/221/InvasionFront_CD3_block7_x5_y7_patient221_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16510.1, + "Centroid Y µm": 17084.6, + "Num Detections": 26889, + "Num Negative": 24082, + "Num Positive": 2807, + "Positive %": 10.44, + "Num Positive per mm^2": 1052.8 + } +} \ No newline at end of file diff --git a/221/InvasionFront_CD3_block7_x6_y7_patient221_1.json b/221/InvasionFront_CD3_block7_x6_y7_patient221_1.json new file mode 100644 index 0000000000000000000000000000000000000000..78be0cd7eab400af5bfdf85d69a1703882f740c2 --- /dev/null +++ b/221/InvasionFront_CD3_block7_x6_y7_patient221_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 17041.0, + "Num Detections": 22011, + "Num Negative": 20247, + "Num Positive": 1764, + "Positive %": 8.014, + "Num Positive per mm^2": 789.87 + } +} \ No newline at end of file diff --git a/221/InvasionFront_CD8_block7_x5_y7_patient221_0.json b/221/InvasionFront_CD8_block7_x5_y7_patient221_0.json new file mode 100644 index 0000000000000000000000000000000000000000..79b8bf018071c2d9850967cbd1153118335c5fa3 --- /dev/null +++ b/221/InvasionFront_CD8_block7_x5_y7_patient221_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17165.9, + "Centroid Y µm": 18590.2, + "Num Detections": 27656, + "Num Negative": 25674, + "Num Positive": 1982, + "Positive %": 7.167, + "Num Positive per mm^2": 748.73 + } +} \ No newline at end of file diff --git a/221/InvasionFront_CD8_block7_x6_y7_patient221_1.json b/221/InvasionFront_CD8_block7_x6_y7_patient221_1.json new file mode 100644 index 0000000000000000000000000000000000000000..49e9270824630167cb12df939aae6fb1b0a51b7e --- /dev/null +++ b/221/InvasionFront_CD8_block7_x6_y7_patient221_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19614.6, + "Centroid Y µm": 18865.0, + "Num Detections": 13147, + "Num Negative": 12728, + "Num Positive": 419, + "Positive %": 3.187, + "Num Positive per mm^2": 336.3 + } +} \ No newline at end of file diff --git a/221/TumorCenter_CD3_block7_x5_y7_patient221_0.json b/221/TumorCenter_CD3_block7_x5_y7_patient221_0.json new file mode 100644 index 0000000000000000000000000000000000000000..95524229ad5e51d589216c3fe212d23ea7fa1bdc --- /dev/null +++ b/221/TumorCenter_CD3_block7_x5_y7_patient221_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 17690.6, + "Num Detections": 26204, + "Num Negative": 23345, + "Num Positive": 2859, + "Positive %": 10.91, + "Num Positive per mm^2": 1028.3 + } +} \ No newline at end of file diff --git a/221/TumorCenter_CD3_block7_x6_y7_patient221_1.json b/221/TumorCenter_CD3_block7_x6_y7_patient221_1.json new file mode 100644 index 0000000000000000000000000000000000000000..16d42a5501bdd062797f2d34dbe73de8bd237fd5 --- /dev/null +++ b/221/TumorCenter_CD3_block7_x6_y7_patient221_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 17815.6, + "Num Detections": 22764, + "Num Negative": 21085, + "Num Positive": 1679, + "Positive %": 7.376, + "Num Positive per mm^2": 684.46 + } +} \ No newline at end of file diff --git a/221/TumorCenter_CD8_block7_x5_y7_patient221_0.json b/221/TumorCenter_CD8_block7_x5_y7_patient221_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3c53cc5d17611366b89f7c388b6276995160cebe --- /dev/null +++ b/221/TumorCenter_CD8_block7_x5_y7_patient221_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15791.6, + "Centroid Y µm": 17715.6, + "Num Detections": 25429, + "Num Negative": 24115, + "Num Positive": 1314, + "Positive %": 5.167, + "Num Positive per mm^2": 533.6 + } +} \ No newline at end of file diff --git a/221/TumorCenter_CD8_block7_x6_y7_patient221_1.json b/221/TumorCenter_CD8_block7_x6_y7_patient221_1.json new file mode 100644 index 0000000000000000000000000000000000000000..50637527ca7d2b55793cc1855f201446f9227f87 --- /dev/null +++ b/221/TumorCenter_CD8_block7_x6_y7_patient221_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 17715.6, + "Num Detections": 24274, + "Num Negative": 23736, + "Num Positive": 538, + "Positive %": 2.216, + "Num Positive per mm^2": 222.6 + } +} \ No newline at end of file diff --git a/221/history_text.txt b/221/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/221/icd_codes.txt b/221/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d1dcbef33712e70bb537f5f0d27e46c0f20ebcd --- /dev/null +++ b/221/icd_codes.txt @@ -0,0 +1 @@ +Uvulakarzinom[C05.2 ] \ No newline at end of file diff --git a/221/ops_codes.txt b/221/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..db9b86c16c258bbbd76367aa86f78012755e98c9 --- /dev/null +++ b/221/ops_codes.txt @@ -0,0 +1 @@ +Exstirpation total transoral (erkrankter) harter und weicher Gaumen[5-272.2 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] PEG-Sonde Anlage[5-431.2 ] \ No newline at end of file diff --git a/221/patient_clinical_data.json b/221/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e48db09025c4f92fe41781434db86af7a920c6e7 --- /dev/null +++ b/221/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/221/patient_pathological_data.json b/221/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7ea4290360bd71188139a3c5046347e11abbd287 --- /dev/null +++ b/221/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "221", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/221/surgery_description.txt b/221/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..38de8b300b9d9329650ae23733270af33c599c55 --- /dev/null +++ b/221/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Free flap (Radial), PEG placement, Panendoscopy diff --git a/221/surgery_report.txt b/221/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b5fa2142fa338b8d7ac1c687a683904691b30b1 --- /dev/null +++ b/221/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthetist. Entry with the 0-degree scope and inspection of the vocal folds and trachea. No abnormalities here. Intubation and insertion with the Kleinsasser tube. Inspection of the oral cavity and oropharynx. The previously described mass on the uvula can be seen here. Mirroring forward to the hypopharynx and larynx area. There are no abnormalities here. Insertion of the tonsil mouth retractor and inspection of the tumorous mass. The tumorous mass infiltrates the entire uvula on the anterior surface and also on the posterior surface. The tumor has extensions on the anterior palatal arch on both sides as well as on the posterior palatal arch on the left side and also infiltrates the posterior surface of the soft palate. First, the mucosa is carefully circumscribed with the monopolar needle. Further dissection with the scissors, initially on the left side. Resection of the uvula and resection of the carcinoma on the right side, including parts of the anterior palatal arch. The posterior palatal arch does not have to be resected on the right side. On the left side, the upper part of the posterior palatal arch is also resected, as it is infiltrated by the tumor. Inspection of the resected tissue. It can be seen that it has been completely removed, but in the area of the posterior soft palate and the posterior palatal arch it is very scarce, so a resection is taken there and also in the area of the anterior palatal arch. The specimens are all thread-marked and sent for frozen section. Pathology cannot detect any tumor cells or carcinoma in situ in the marginal area and confirms that the carcinoma was resected in sano. Hemostasis using bipolar coagulation and completion of the procedure. During the rapid incision break, a PEG was placed using the suture pull-through method with good diaphanoscopy. Please check the swallowing function postoperatively. In case of regurgitation, plan a radial flap as part of the neck dissection. A neck dissection must be performed on both sides for this carcinoma, only then can the patient be presented at the tumor conference. \ No newline at end of file diff --git a/222/InvasionFront_CD3_block10_x1_y2_patient222_0.json b/222/InvasionFront_CD3_block10_x1_y2_patient222_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3c8e4a3cb188d8ebc50c8c3b3e18d3a5670ba4b9 --- /dev/null +++ b/222/InvasionFront_CD3_block10_x1_y2_patient222_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 10144.6, + "Num Detections": 22983, + "Num Negative": 20814, + "Num Positive": 2169, + "Positive %": 9.437, + "Num Positive per mm^2": 913.86 + } +} \ No newline at end of file diff --git a/222/InvasionFront_CD3_block10_x2_y2_patient222_1.json b/222/InvasionFront_CD3_block10_x2_y2_patient222_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7c7b660c62a6ce067f1d0b41333d684653f691e1 --- /dev/null +++ b/222/InvasionFront_CD3_block10_x2_y2_patient222_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9270.1, + "Centroid Y µm": 10444.5, + "Num Detections": 22327, + "Num Negative": 20511, + "Num Positive": 1816, + "Positive %": 8.134, + "Num Positive per mm^2": 854.61 + } +} \ No newline at end of file diff --git a/222/InvasionFront_CD8_block10_x1_y2_patient222_0.json b/222/InvasionFront_CD8_block10_x1_y2_patient222_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5d054918089a3dce051687726eedb1e3683778f1 --- /dev/null +++ b/222/InvasionFront_CD8_block10_x1_y2_patient222_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5672.0, + "Centroid Y µm": 10369.5, + "Num Detections": 23004, + "Num Negative": 16145, + "Num Positive": 6859, + "Positive %": 29.82, + "Num Positive per mm^2": 2910.9 + } +} \ No newline at end of file diff --git a/222/InvasionFront_CD8_block10_x2_y2_patient222_1.json b/222/InvasionFront_CD8_block10_x2_y2_patient222_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d058ca3b69ddae582bdc7376ad9325fbef60e42c --- /dev/null +++ b/222/InvasionFront_CD8_block10_x2_y2_patient222_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7970.8, + "Centroid Y µm": 10344.5, + "Num Detections": 24568, + "Num Negative": 22447, + "Num Positive": 2121, + "Positive %": 8.633, + "Num Positive per mm^2": 941.32 + } +} \ No newline at end of file diff --git a/222/TumorCenter_CD3_block10_x1_y2_patient222_0.json b/222/TumorCenter_CD3_block10_x1_y2_patient222_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f6d7f185156e9a32b96e1395c4d154638ca09cff --- /dev/null +++ b/222/TumorCenter_CD3_block10_x1_y2_patient222_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 5397.1, + "Num Detections": 23197, + "Num Negative": 20041, + "Num Positive": 3156, + "Positive %": 13.61, + "Num Positive per mm^2": 1275.3 + } +} \ No newline at end of file diff --git a/222/TumorCenter_CD3_block10_x2_y2_patient222_1.json b/222/TumorCenter_CD3_block10_x2_y2_patient222_1.json new file mode 100644 index 0000000000000000000000000000000000000000..28acb9f7552012ffd03eb37fcf98f121c2138d1d --- /dev/null +++ b/222/TumorCenter_CD3_block10_x2_y2_patient222_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8845.3, + "Centroid Y µm": 5297.2, + "Num Detections": 23669, + "Num Negative": 20484, + "Num Positive": 3185, + "Positive %": 13.46, + "Num Positive per mm^2": 1403.5 + } +} \ No newline at end of file diff --git a/222/TumorCenter_CD8_block10_x1_y2_patient222_0.json b/222/TumorCenter_CD8_block10_x1_y2_patient222_0.json new file mode 100644 index 0000000000000000000000000000000000000000..75bf493474828403aa66ab00b6ebd5652def42c1 --- /dev/null +++ b/222/TumorCenter_CD8_block10_x1_y2_patient222_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3373.2, + "Centroid Y µm": 6271.7, + "Num Detections": 19796, + "Num Negative": 8790, + "Num Positive": 11006, + "Positive %": 55.6, + "Num Positive per mm^2": 4607.7 + } +} \ No newline at end of file diff --git a/222/TumorCenter_CD8_block10_x2_y2_patient222_1.json b/222/TumorCenter_CD8_block10_x2_y2_patient222_1.json new file mode 100644 index 0000000000000000000000000000000000000000..152aac15069a9343a19e4b2804ca29ee14089c46 --- /dev/null +++ b/222/TumorCenter_CD8_block10_x2_y2_patient222_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5771.9, + "Centroid Y µm": 5971.8, + "Num Detections": 20545, + "Num Negative": 8457, + "Num Positive": 12088, + "Positive %": 58.84, + "Num Positive per mm^2": 5012.0 + } +} \ No newline at end of file diff --git a/222/history_text.txt b/222/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..274964c6bfaf6654ff9d618ea91242b9c35c0a50 --- /dev/null +++ b/222/history_text.txt @@ -0,0 +1 @@ +A poorly differentiated squamous cell carcinoma was confirmed in the patient by cervical lymph node extirpation. Although there was initially no evidence of primary carcinoma, the follow-up ENT examination revealed tonsillar carcinoma. Sonographic evidence of cN2b neck status. \ No newline at end of file diff --git a/222/icd_codes.txt b/222/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/222/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/222/ops_codes.txt b/222/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f74e814c22ddc3d0be4bc30a60aea4f762a9d11f --- /dev/null +++ b/222/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] Tonsillektomie radikal transoral[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/222/patient_clinical_data.json b/222/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6000c40de36278784324747b11c08b3eb002e6c4 --- /dev/null +++ b/222/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/222/patient_pathological_data.json b/222/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6a4a254841590b33d4ed39e5e769e9f191669ff8 --- /dev/null +++ b/222/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "222", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/222/surgery_description.txt b/222/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..50312bf02ac9be42bdb574ea1e368d8a571c1efe --- /dev/null +++ b/222/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Neck dissection diff --git a/222/surgery_report.txt b/222/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b528220876d11e99b4a8339f640d3cc78c79a9bf --- /dev/null +++ b/222/surgery_report.txt @@ -0,0 +1 @@ +Firstly, inspection of the oral cavity: insertion of the tonsil plug and inspection of the tonsil region. On the left side, the tonsil is fissured with a small fibroma-like appendage. On the right side, the tonsil shows exophytic changes. A clear induration can be palpated, which extends to the lower tonsil pole. Macroscopically, a T2 tonsillar carcinoma is highly suspected. Then perform an enoral tumor resection: Resection of the tumor including the anterior palatal arch. Successive dissection of the tumorous mass with removal of the pharyngeal muscles; however, the posterior palatal arch can remain intact and is not infiltrated macroscopically or by palpation. Inclusion of the lower tonsil pole and a circumscribed area of the base of the tongue. The preparation is thread-marked for frozen section diagnostics. The fibroma-like appendage of the left tonsil is now removed. Enter with the small bore tube and re-inspect and re-inspect the hypopharynx and larynx. Here, inconspicuous conditions are seen in the region of the base of the tongue, the vallecula and the epiglottis, as well as inconspicuous conditions in the region of the hypopharynx with well-developed piriform sinuses, and the postcricoid region up to the esophageal opening is also clear. Adjustment of the endolarynx. Inconspicuous conditions here as well. The flexible esophagogastroscopy is then performed: easy to see through to the stomach. Inconspicuous conditions in the stomach area. Now, with excellent diaphanoscopy, insertion of a PEG tube. After a problem-free puncture of the stomach using the usual thread pull-through method. Inspection of the esophagus on reflection. Mucosal conditions are visible on all sides, but without any suspicious changes. The frozen section diagnosis now confirms the diagnosis of squamous cell carcinoma. In the area of the medio-caudal marking, higher grade dysplasia is visible, otherwise the frozen section shows an R0 resection. A resection is now performed medio-caudally towards the base of the tongue and the posterior pharyngeal wall, extending to the vallecula. A final marginal sample covering the entire area is sent for frozen section diagnostics and later assessed as tumor-free. After resection, a barely covered, pulsating structure is found at the transition from the oropharynx to the hypopharynx, which could correspond to the internal carotid artery on Doppler sonography, but is otherwise located at the level of the exit of the lingual artery. Decision to explore as part of the neck dissection. In the case of dry enoral conditions, repositioning for neck dissection on both sides: injection with xylocaine and adrenaline. Start with the right side: To do this, make a skin incision by cutting around the previous scar submandibularly. Subcutaneous scarring in the area of the skin incision. Exposure of the sternocleidomastoid after cutting through platysma remnants. A scar block extends into the depths in the area of the previous operation. Dissection of the sternocleidomastoid muscle. Exposure of the accessorius nerve. Then exposure of the omohyoid muscle. Dissection of the omohyoid muscle and exposure up to the hyoid. Exposure of the submandibular gland. Pronounced scarring here too. Exposure of the digastric muscle. Exposure of the facial vein. Exposure of the superior thyroid artery and the hypoglossal nerve and successive removal of the anterior neck preparation. Pronounced scarring in the area of the anterior jugular vein. A clear tumorous mass is palpable caudal to the vein, which is located directly on the internal jugular vein and appears to infiltrate it palpatorily. A tumor cone also grows parallel to the vein cranially below the accessorius level. Further dissection of the vein. Pronounced scarring, but also clear evidence of tumor infiltration, so that the decision is made to resect the vein. Caudal exposure of the vein. Exposure of the common carotid artery and the vagus nerve. Removal of the vein after ligation and repositioning and cranial dissection. The mass infiltrates a few plexus branches. These are also resected. Now continue to expose the common carotid artery. Identification of the exit of the superior thyroid artery. Identification of the external and internal carotid artery. Cranial to the exit of the superior thyroid artery, a very strong vessel branches off and runs directly towards the resection area. Trace and visualize this vessel. In terms of caliber and localization, this vessel corresponds to the one seen enorally and is then removed after ligation and repositioning. Now successive dissection of the lymph node metastasis cranially. Cranial removal of the vein, also after ligation and repositioning. The accessor nerve can be spared. If there is significant scarring, there is infiltration of the tumor. Circumscribed with the sternocleidomastoid muscle, this is partially resected. The accessorius triangle has already been resected. Level Vb is now removed while carefully preserving the supraclavicular vessels. Final inspection and, if the wound is dry, insertion of a 10 Redon drain and careful two-layer wound closure and turning to the opposite side: skin incision. Cut through subcutaneous tissue. Exposure of the platysma. Dissection of the platysma and creation of a platysmal flap. Exposure of the external jugular vein and the auricular nerve. These are spared (as on the opposite side). Exposure of the sternocleidomastoid muscle. Dissection and exposure of the accessorius nerve. Exposure and free preparation of the omohyoid muscle up to the hyoid. Exposure of the submandibular gland. Completing the dissection towards the hyoid. Exposure of the facial vein and preservation of the vein. Expose the digastric muscle posteriorly. Now successively expose the anterior neck preparation. Expose the superior thyroid artery and the hypoglossal nerve as well as the cervical artery. Preservation of the structures. Further exposure of the facial vein and free preparation of the internal jugular vein. Cranial preparation. It can now be seen that the nervus accessorius runs behind the vein on this side. Careful protection. Clearing of the accessorius triangle and completion of level Va. If the wound is dry, irrigation of the wound and two-layer wound closure after insertion of a 10-gauge Redon drain. Now re-inspect enorally. Finally, meticulous hemostasis. The previously identified vessel can no longer be visualized by inspection and Doppler sonography. Now mucosal adaptation in the area of the vallecula and hypopharynx and, after final inspection, completion of the procedure. On the way to the recovery room, the patient can now be aspirated with fresh blood. In addition, saturation is only 90% with oxygen supply, so the patient is taken back to the operating room and reintubated. Re-inspection. A discrete, diffuse, venous hemorrhage is found, which is treated by meticulous hemostasis. Finally, absolutely dry wound conditions. Due to urgent indication by and anesthesia, the patient is now tracheostomized. Repositioning of the patient. After infiltration anesthesia with xylocaine and the addition of adrenaline, a sparing, horizontal skin incision is made below the cricoid cartilage. Cut through the subcutaneous tissue. Exposure of the prelaryngeal musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. An extremely thin thyroid isthmus is visible. This is bipolarly coagulated and severed. Further exposure of the anterior surface of the trachea and insertion between the 2nd and 3rd tracheal ring. Performing a mucocutaneous anastomosis and subsequent problem-free reintubation to an 8-gauge tracheoflex cannula. Conclusion: At least cT2 cN2b oropharyngeal carcinoma on the right. Performance of a modified radical neck dissection on the right with resection of the internal jugular vein and partial resection of the sternocleidomastoid muscle. The patient should remain fasting for at least 3 to 5 days. After this, a diet should be started, initially with liquid food. Rapid decannulation should be aimed for. If possible, the first cannula should not be changed before the 4th postoperative day. Staging should also be supplemented during the further inpatient course. Due to the extent of the tumor, adjuvant therapy is certainly indicated. \ No newline at end of file diff --git a/223/InvasionFront_CD3_block17_x1_y7_patient223_0.json b/223/InvasionFront_CD3_block17_x1_y7_patient223_0.json new file mode 100644 index 0000000000000000000000000000000000000000..882b56ead0e70d4e82a0feba4c367ba1032be4b2 --- /dev/null +++ b/223/InvasionFront_CD3_block17_x1_y7_patient223_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3573.1, + "Centroid Y µm": 22563.1, + "Num Detections": 25227, + "Num Negative": 24033, + "Num Positive": 1194, + "Positive %": 4.733, + "Num Positive per mm^2": 452.01 + } +} \ No newline at end of file diff --git a/223/InvasionFront_CD3_block17_x2_y7_patient223_1.json b/223/InvasionFront_CD3_block17_x2_y7_patient223_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b2b6eadeaf75f4e2c4ad400897cefad0b12c39ae --- /dev/null +++ b/223/InvasionFront_CD3_block17_x2_y7_patient223_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5946.9, + "Centroid Y µm": 22613.0, + "Num Detections": 10568, + "Num Negative": 10389, + "Num Positive": 179, + "Positive %": 1.694, + "Num Positive per mm^2": 158.01 + } +} \ No newline at end of file diff --git a/223/InvasionFront_CD8_block17_x1_y7_patient223_0.json b/223/InvasionFront_CD8_block17_x1_y7_patient223_0.json new file mode 100644 index 0000000000000000000000000000000000000000..39e181654a643d3ba85050c941470a5284862060 --- /dev/null +++ b/223/InvasionFront_CD8_block17_x1_y7_patient223_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4022.9, + "Centroid Y µm": 17765.6, + "Num Detections": 24881, + "Num Negative": 24135, + "Num Positive": 746, + "Positive %": 2.998, + "Num Positive per mm^2": 290.32 + } +} \ No newline at end of file diff --git a/223/InvasionFront_CD8_block17_x2_y7_patient223_1.json b/223/InvasionFront_CD8_block17_x2_y7_patient223_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6df7bbc36179e919f6b5c2912b0e894ebb832d3e --- /dev/null +++ b/223/InvasionFront_CD8_block17_x2_y7_patient223_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 17665.6, + "Num Detections": 16593, + "Num Negative": 16240, + "Num Positive": 353, + "Positive %": 2.127, + "Num Positive per mm^2": 176.32 + } +} \ No newline at end of file diff --git a/223/TumorCenter_CD3_block17_x1_y7_patient223_0.json b/223/TumorCenter_CD3_block17_x1_y7_patient223_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bf6f7927597d35eb4477a3d18a2a8c34cff81104 --- /dev/null +++ b/223/TumorCenter_CD3_block17_x1_y7_patient223_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3848.0, + "Centroid Y µm": 17290.8, + "Num Detections": 14951, + "Num Negative": 14627, + "Num Positive": 324, + "Positive %": 2.167, + "Num Positive per mm^2": 180.68 + } +} \ No newline at end of file diff --git a/223/TumorCenter_CD3_block17_x2_y7_patient223_1.json b/223/TumorCenter_CD3_block17_x2_y7_patient223_1.json new file mode 100644 index 0000000000000000000000000000000000000000..62014c12aac6d41f3c6fd1c6f0fd598c2b27d8fe --- /dev/null +++ b/223/TumorCenter_CD3_block17_x2_y7_patient223_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 17390.8, + "Num Detections": 23324, + "Num Negative": 22521, + "Num Positive": 803, + "Positive %": 3.443, + "Num Positive per mm^2": 303.77 + } +} \ No newline at end of file diff --git a/223/TumorCenter_CD8_block17_x1_y7_patient223_0.json b/223/TumorCenter_CD8_block17_x1_y7_patient223_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2a9e6d5eed6c7272818e14fcd95a302ff9d3dec3 --- /dev/null +++ b/223/TumorCenter_CD8_block17_x1_y7_patient223_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6577.2, + "Centroid Y µm": 31287.1, + "Num Detections": 16573, + "Num Negative": 16385, + "Num Positive": 188, + "Positive %": 1.134, + "Num Positive per mm^2": 110.32 + } +} \ No newline at end of file diff --git a/223/TumorCenter_CD8_block17_x2_y7_patient223_1.json b/223/TumorCenter_CD8_block17_x2_y7_patient223_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3dc4e1aa3b9f34b03efae1378ce69115cb2b6347 --- /dev/null +++ b/223/TumorCenter_CD8_block17_x2_y7_patient223_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8970.3, + "Centroid Y µm": 31333.4, + "Num Detections": 25540, + "Num Negative": 24286, + "Num Positive": 1254, + "Positive %": 4.91, + "Num Positive per mm^2": 474.53 + } +} \ No newline at end of file diff --git a/223/history_text.txt b/223/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ca7de8424eed622c2cc1846594ff135dc60c948a --- /dev/null +++ b/223/history_text.txt @@ -0,0 +1 @@ +In the patient, a G2 squamous cell carcinoma of the left vocal fold was histologically confirmed during a panendoscopy. According to the surgical report, it extended anteriorly to the anterior commissure, posteriorly it was clearly distinguishable from the vocal process and there was no infiltration in the morgue or subglottic sinus. In the interdisciplinary tumor conference, a partial laryngeal resection from the outside was indicated when the carcinoma made contact with the thyroid cartilage on computed tomography. \ No newline at end of file diff --git a/223/icd_codes.txt b/223/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/223/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/223/ops_codes.txt b/223/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d765748f64498ed03871aeb3688933631bb3390 --- /dev/null +++ b/223/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Chordektomie durch Thyreotomie[5-302.2 ] \ No newline at end of file diff --git a/223/patient_clinical_data.json b/223/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e1126d194024add71e97f23173a495107126b7f0 --- /dev/null +++ b/223/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 16, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/223/patient_pathological_data.json b/223/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8406a3943391cadeec95b8c07621d3f414a15c35 --- /dev/null +++ b/223/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "223", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/223/surgery_description.txt b/223/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6fad1ea9d182ede95a9d60bc90da668fdc767797 --- /dev/null +++ b/223/surgery_description.txt @@ -0,0 +1 @@ +Frontolateral partial laryngeal resection from the outside diff --git a/223/surgery_report.txt b/223/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..75d06c5f5c2554ee0258fa3fb24fe9c6f26e6272 --- /dev/null +++ b/223/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues and intubation, entry with the Kleinsasser C-tube and inspection of the endolarynx. This reveals an extensive mass in the area of the left vocal fold, which macroscopically does not infiltrate the vocal process. The mass extends anteriorly to the anterior commissure and there is no infiltration into the subglottic region or into the depth of the morgue sinus. Now inject 10 ml of Ultracaine solution into a horizontal skin fold and cover sterilely. First make a skin incision approx. 5 cm long. Split the prelaryngeal muscles in the middle. Expose the thyroid cartilage plate and the ligamentum conicum. The ligamentum conicum is incised centrally with the monopolar. The perichondrium, the thyroid cartilage paramedian on the right, is then incised. Now mobilize the perichondrium on the thyroid cartilage plates laterally and perform a median chondrotomy and open up the larynx. The anterior commissure is now split paramedian on the right side in order to safely remove the tumor in a healthy state. Then incision parallel to the vocal fold in the area of the subglottic slope approx. 4 mm caudal to the glottic plane. Mobilization of the vocal fold, including the vocalis muscle in the anterior region. There is no palpable infiltration of the musculature here, so that the muscle is now largely left in place during posterior dissection. Now make another incision cranial to the morgue sinus with the scalpel parallel to the vocal fold plane so that the vocal fold is now completely mobilized from anterior to posterior up to the vocal process. Push off the mucosa medially from the vocal process and then remove the histological specimen, which is sent for final histology. Hemostasis in the area of the vocalis muscle with bipolar coagulation. A branch of the superior thyroid artery is also coagulated with bipolar coagulation. Now take marginal samples. Samples are taken from the right anterior commissure. A strip of mucosa from anterior to posterior is sent in for a frozen section both subglottically and supraglottically. Now take a marginal sample in the area of the medial arytenoid cartilage towards the posterior commissure. Mobilization of the pocket fold, which is now inserted caudally into the former anterior commissure and sutured to the subglottic mucosa. Initially, the entire surgical area is closed, but the intraoperative frozen section reveals an invasive carcinoma in the marginal sample of the arytenoid cartilage. Therefore, reopening of the larynx and case discussion with . Decision to perform another mucosal resection in the area of the medial ary and posterior commissure and in the area of the cranial ary, which are sent for urgent histology. Resection of the arytenoid cartilage should initially be avoided due to the age of the patient and the resulting right prognosis with regard to aspiration. Now check for bloodlessness, which is present. Insertion of 2 drill holes each in the area of the thyroid cartilage plate. Adaptation of the thyroid cartilage plates using Vicryl 3-0. The ligamentum conicum is also closed and fixed to the thyroid cartilage plates through the drill hole. The mobilized perichondrium is also adapted as far as possible. Suturing of the prelaryngeal musculature after insertion of a flap. Subcutaneous and skin suturing and completion of the procedure. Conclusion: Intraoperative findings show a much more pronounced tumor extension towards the arytenoid cartilage than previously described in the panendoscopy. After removal of the tumor from the vocal process, the marginal specimen unfortunately still shows tumor growth. In a case discussion with , a resection is performed in the area of the medial arytenoid and a second resection in the area of the cranial arytenoid cartilage. These are sent for urgent histology. Resection of the arytenoid cartilage is not initially performed due to the patient's age and the associated increased risk of aspiration. If further tumor is detected in the post-resectate, laser resection of the arytenoid cartilage with the risk of a functionally necessary laryngectomy in the event of aspiration and radiotherapy as an alternative must be discussed with the patient. \ No newline at end of file diff --git a/224/InvasionFront_CD3_block21_x5_y6_patient224_0.json b/224/InvasionFront_CD3_block21_x5_y6_patient224_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a3e0fcc12eb8d7b2d3a466c2f71be5aa348af334 --- /dev/null +++ b/224/InvasionFront_CD3_block21_x5_y6_patient224_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 25861.3, + "Num Detections": 20463, + "Num Negative": 19596, + "Num Positive": 867, + "Positive %": 4.237, + "Num Positive per mm^2": 360.58 + } +} \ No newline at end of file diff --git a/224/InvasionFront_CD3_block21_x6_y6_patient224_1.json b/224/InvasionFront_CD3_block21_x6_y6_patient224_1.json new file mode 100644 index 0000000000000000000000000000000000000000..04cc1a0090b0313a3ca382deb5825d519b7a5ed5 --- /dev/null +++ b/224/InvasionFront_CD3_block21_x6_y6_patient224_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21413.7, + "Centroid Y µm": 25936.3, + "Num Detections": 22858, + "Num Negative": 22207, + "Num Positive": 651, + "Positive %": 2.848, + "Num Positive per mm^2": 275.38 + } +} \ No newline at end of file diff --git a/224/InvasionFront_CD8_block21_x5_y6_patient224_0.json b/224/InvasionFront_CD8_block21_x5_y6_patient224_0.json new file mode 100644 index 0000000000000000000000000000000000000000..478de99e6eec98b3b04bc37b17c9ab73da1874e9 --- /dev/null +++ b/224/InvasionFront_CD8_block21_x5_y6_patient224_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 14767.2, + "Num Detections": 21939, + "Num Negative": 21616, + "Num Positive": 323, + "Positive %": 1.472, + "Num Positive per mm^2": 121.8 + } +} \ No newline at end of file diff --git a/224/InvasionFront_CD8_block21_x6_y6_patient224_1.json b/224/InvasionFront_CD8_block21_x6_y6_patient224_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1e88b88f459e160c306847224184f310f0a654d8 --- /dev/null +++ b/224/InvasionFront_CD8_block21_x6_y6_patient224_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18640.1, + "Centroid Y µm": 14742.2, + "Num Detections": 18810, + "Num Negative": 18641, + "Num Positive": 169, + "Positive %": 0.8985, + "Num Positive per mm^2": 81.97 + } +} \ No newline at end of file diff --git a/224/TumorCenter_CD3_block21_x5_y6_patient224_0.json b/224/TumorCenter_CD3_block21_x5_y6_patient224_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6f1dbe5070e64dcc412a3814dca0d6880607cd04 --- /dev/null +++ b/224/TumorCenter_CD3_block21_x5_y6_patient224_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16116.5, + "Centroid Y µm": 17590.7, + "Num Detections": 19586, + "Num Negative": 19142, + "Num Positive": 444, + "Positive %": 2.267, + "Num Positive per mm^2": 194.93 + } +} \ No newline at end of file diff --git a/224/TumorCenter_CD3_block21_x6_y6_patient224_1.json b/224/TumorCenter_CD3_block21_x6_y6_patient224_1.json new file mode 100644 index 0000000000000000000000000000000000000000..39f61aa4fed805db9064f1b79a99e14e5889916b --- /dev/null +++ b/224/TumorCenter_CD3_block21_x6_y6_patient224_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 17515.7, + "Num Detections": 23167, + "Num Negative": 21957, + "Num Positive": 1210, + "Positive %": 5.223, + "Num Positive per mm^2": 479.63 + } +} \ No newline at end of file diff --git a/224/TumorCenter_CD8_block21_x5_y6_patient224_0.json b/224/TumorCenter_CD8_block21_x5_y6_patient224_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d0c7c9d95b6f867cb8c761cad01d591e96512a7 --- /dev/null +++ b/224/TumorCenter_CD8_block21_x5_y6_patient224_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 29959.1, + "Num Detections": 22748, + "Num Negative": 22467, + "Num Positive": 281, + "Positive %": 1.235, + "Num Positive per mm^2": 120.38 + } +} \ No newline at end of file diff --git a/224/TumorCenter_CD8_block21_x6_y6_patient224_1.json b/224/TumorCenter_CD8_block21_x6_y6_patient224_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4ae76c6fe75e12b4be6a52bb949e789dcfd38c13 --- /dev/null +++ b/224/TumorCenter_CD8_block21_x6_y6_patient224_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21013.9, + "Centroid Y µm": 30109.1, + "Num Detections": 24197, + "Num Negative": 23809, + "Num Positive": 388, + "Positive %": 1.604, + "Num Positive per mm^2": 153.57 + } +} \ No newline at end of file diff --git a/224/history_text.txt b/224/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7157fb42a0e96c0e4cf4ae66f8b8d3dba2c837ca --- /dev/null +++ b/224/history_text.txt @@ -0,0 +1 @@ +Mr. has a histologically confirmed vocal fold carcinoma of the entire left thyroid gland, which also extends to the right. Therefore, there is now an indication for transoral laser resection. \ No newline at end of file diff --git a/224/icd_codes.txt b/224/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d220406bb9f820a9488c92a1fdebe2fb59920ef7 --- /dev/null +++ b/224/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 ] \ No newline at end of file diff --git a/224/ops_codes.txt b/224/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b04c7e3d4191f830c73f92dfb234cee2f34b3ff2 --- /dev/null +++ b/224/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Exzision, mikrolaryngoskopisch[5-300.2 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Destruktion: Laserkoagulation[5-300.31 ] Andere partielle Laryngektomie: Chordektomie, endolaryngeal[5-302.1 ] \ No newline at end of file diff --git a/224/patient_clinical_data.json b/224/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..50c307b3081c851f2fa83ced6be80611bca805a7 --- /dev/null +++ b/224/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/224/patient_pathological_data.json b/224/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1813ab6f781a0ca499d5bfb48d9b5242f23fe3b0 --- /dev/null +++ b/224/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "224", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/224/surgery_description.txt b/224/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b105d2736b2945d7d53421a4b00db8b71e963437 --- /dev/null +++ b/224/surgery_description.txt @@ -0,0 +1 @@ +Laser chordectomy left, Partial chordectomy right diff --git a/224/surgery_report.txt b/224/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fd47088fe33ca4e479bedc86056b579a3aabc0e5 --- /dev/null +++ b/224/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthetist, a microlaryngoscopy is performed first. Here the verrucous carcinoma of the entire left vocal fold can be confirmed. On the right, the findings are limited to the anterior third of the left vocal fold. Now setting with the Kleinsasser C-tube. Start resection with the CO2 laser at 3 watts in the posterior region, directly at the border with the vocal process of the arytenoid cartilage. Then also partial resection of the pocket fold on the left side. The resection extends well into the subglottic area. Approximately 5 mm in front of the anterior commissure, the first part of the tumor preparation is resected. This is followed by repositioning with the Kleinsasser D-tube and removal of the remaining tumor up to the anterior commissure. The thyroid cartilage is resected from its inner side together with the perichondrium in this area. Hemostasis by means of monopolar coagulation, using the forceps and the suction cup. Now turn to the right side. Here there is a much less exophytic aspect, but more a restless mucosa, which is why a partial chordectomy is performed here, leaving parts of the ligament and the vocalis muscle intact. This extends approximately 8 mm posteriorly. After complete resection with the laser, the frozen section diagnosis is performed. Two strips are taken from the right side, one cranial and one caudal, and from the left side one anterior, one caudal and one posterior. A frozen section in the cranial region is not performed due to the resection of the pocket fold and the resulting large distance to the tumor. The frozen section diagnosis resulted in an R0 resection. After renewed careful hemostasis, the procedure is completed without bleeding and without complications. The patient should be presented at the tumor conference and undergo a follow-up microlaryngoscopy in 8 weeks. In addition, care should be taken to also perform a Dacron foil or Keel system in the event of synechiae of the anterior commissure. \ No newline at end of file diff --git a/225/InvasionFront_CD3_block1_x3_y4_patient225_0.json b/225/InvasionFront_CD3_block1_x3_y4_patient225_0.json new file mode 100644 index 0000000000000000000000000000000000000000..66e076c6e4ca5ed8ccb96bebb9ed935f4b5f9685 --- /dev/null +++ b/225/InvasionFront_CD3_block1_x3_y4_patient225_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11693.8, + "Centroid Y µm": 11768.8, + "Num Detections": 23645, + "Num Negative": 22080, + "Num Positive": 1565, + "Positive %": 6.619, + "Num Positive per mm^2": 579.71 + } +} \ No newline at end of file diff --git a/225/InvasionFront_CD3_block1_x4_y4_patient225_1.json b/225/InvasionFront_CD3_block1_x4_y4_patient225_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a46615815296b74e9a45ad97d604617e8f54ca6 --- /dev/null +++ b/225/InvasionFront_CD3_block1_x4_y4_patient225_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14292.4, + "Centroid Y µm": 11893.7, + "Num Detections": 23983, + "Num Negative": 22020, + "Num Positive": 1963, + "Positive %": 8.185, + "Num Positive per mm^2": 723.41 + } +} \ No newline at end of file diff --git a/225/InvasionFront_CD8_block1_x3_y4_patient225_0.json b/225/InvasionFront_CD8_block1_x3_y4_patient225_0.json new file mode 100644 index 0000000000000000000000000000000000000000..27bfcefbc4a31efc6440ecc4d5be6f29ebffbb0f --- /dev/null +++ b/225/InvasionFront_CD8_block1_x3_y4_patient225_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11718.8, + "Centroid Y µm": 10344.5, + "Num Detections": 23644, + "Num Negative": 21720, + "Num Positive": 1924, + "Positive %": 8.137, + "Num Positive per mm^2": 705.49 + } +} \ No newline at end of file diff --git a/225/InvasionFront_CD8_block1_x4_y4_patient225_1.json b/225/InvasionFront_CD8_block1_x4_y4_patient225_1.json new file mode 100644 index 0000000000000000000000000000000000000000..98ab231efb9310e5cf313bcd4509027e4d5efa4e --- /dev/null +++ b/225/InvasionFront_CD8_block1_x4_y4_patient225_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 10544.4, + "Num Detections": 23203, + "Num Negative": 21305, + "Num Positive": 1898, + "Positive %": 8.18, + "Num Positive per mm^2": 700.29 + } +} \ No newline at end of file diff --git a/225/TumorCenter_CD3_block1_x3_y6_patient225_0.json b/225/TumorCenter_CD3_block1_x3_y6_patient225_0.json new file mode 100644 index 0000000000000000000000000000000000000000..acabd506ae9afc5cb09878755acf0a124d17b804 --- /dev/null +++ b/225/TumorCenter_CD3_block1_x3_y6_patient225_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10744.3, + "Centroid Y µm": 15266.9, + "Num Detections": 21433, + "Num Negative": 14279, + "Num Positive": 7154, + "Positive %": 33.38, + "Num Positive per mm^2": 3063.0 + } +} \ No newline at end of file diff --git a/225/TumorCenter_CD3_block1_x4_y6_patient225_1.json b/225/TumorCenter_CD3_block1_x4_y6_patient225_1.json new file mode 100644 index 0000000000000000000000000000000000000000..db8e233628028b35317b9ad494b1caa4f90bad61 --- /dev/null +++ b/225/TumorCenter_CD3_block1_x4_y6_patient225_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13168.0, + "Centroid Y µm": 15117.0, + "Num Detections": 17632, + "Num Negative": 15945, + "Num Positive": 1687, + "Positive %": 9.568, + "Num Positive per mm^2": 853.41 + } +} \ No newline at end of file diff --git a/225/TumorCenter_CD8_block1_x3_y4_patient225_0.json b/225/TumorCenter_CD8_block1_x3_y4_patient225_0.json new file mode 100644 index 0000000000000000000000000000000000000000..92f3ffce6e554a560873c4ced1b1394940ec7fef --- /dev/null +++ b/225/TumorCenter_CD8_block1_x3_y4_patient225_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 18740.1, + "Num Detections": 25316, + "Num Negative": 23163, + "Num Positive": 2153, + "Positive %": 8.505, + "Num Positive per mm^2": 766.58 + } +} \ No newline at end of file diff --git a/225/TumorCenter_CD8_block1_x4_y4_patient225_1.json b/225/TumorCenter_CD8_block1_x4_y4_patient225_1.json new file mode 100644 index 0000000000000000000000000000000000000000..969d052463129a24a590bbcf0e83a68d3b26e171 --- /dev/null +++ b/225/TumorCenter_CD8_block1_x4_y4_patient225_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 18740.1, + "Num Detections": 23277, + "Num Negative": 21717, + "Num Positive": 1560, + "Positive %": 6.702, + "Num Positive per mm^2": 582.65 + } +} \ No newline at end of file diff --git a/225/history_text.txt b/225/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..55346f2554c6141a4ce37d2082092278b4fba678 --- /dev/null +++ b/225/history_text.txt @@ -0,0 +1 @@ +The patient is scheduled for radiochemotherapy of a mediastinal metastasized esophageal carcinoma. A second carcinoma has been detected in the base of the tongue, which needs to be removed before RCT can begin. Therefore indication for the above mentioned procedure. \ No newline at end of file diff --git a/225/icd_codes.txt b/225/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/225/ops_codes.txt b/225/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ef1365efef6c32e3330053bfef9f008a0f900674 --- /dev/null +++ b/225/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.01 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/225/patient_clinical_data.json b/225/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ce62477955d90c39f69ef2784125ba3ac53aca03 --- /dev/null +++ b/225/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/225/patient_pathological_data.json b/225/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9ec5638426feb3660d149bd506022aa04fe47cbe --- /dev/null +++ b/225/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "225", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/225/surgery_description.txt b/225/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ccc88f3f872d0b1b5ec79ac46c9e2f1672089ab8 --- /dev/null +++ b/225/surgery_description.txt @@ -0,0 +1 @@ +Pharyngeal partial resection and Tracheotomy diff --git a/225/surgery_report.txt b/225/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..52c1e2045fb32cc3a0dc83b02d8c6c477412d058 --- /dev/null +++ b/225/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia and intubation of the patient by the anesthesia colleagues. Then insertion of the mouth blocker and exposure of the tumor region. A coarse, spherical tumor is found at the base of the tongue on the right side. Then insertion of the robotic arms and optics and start of tumor resection. Grasping the tumor and successive resection of the tumor tissue in the macroscopically healthy area. Sending the entire specimen for frozen section. In the area of the wound bed, the wound edges are macroscopically healthy, but microscopically very closely resected. Therefore, another resection was performed here for final histology. Decision to perform a tracheotomy due to the wound area. Incision in the area of the cricoid cartilage. The neck can hardly be overstretched and is very short. Dissection down to the muscles and the thyroid gland. Cut through the thyroid isthmus. Exposure of the anterior wall of the trachea. Insertion between the 1st and 2nd tracheal cartilage. Creation of a visor tracheotomy. Creation of a mucocutaneous anastomosis and insertion of an 8 mm tracheal cannula. The patient is admitted to the intensive care unit for postoperative monitoring. Please present the patient at the tumor conference after receiving the histology. \ No newline at end of file diff --git a/226/InvasionFront_CD3_block17_x5_y6_patient226_0.json b/226/InvasionFront_CD3_block17_x5_y6_patient226_0.json new file mode 100644 index 0000000000000000000000000000000000000000..23d96d091500f55b6b17459777f9dd1e5af72297 --- /dev/null +++ b/226/InvasionFront_CD3_block17_x5_y6_patient226_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 20339.2, + "Num Detections": 16681, + "Num Negative": 16300, + "Num Positive": 381, + "Positive %": 2.284, + "Num Positive per mm^2": 160.95 + } +} \ No newline at end of file diff --git a/226/InvasionFront_CD3_block17_x6_y6_patient226_1.json b/226/InvasionFront_CD3_block17_x6_y6_patient226_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd2f268eaba33c19346525780e5d17544cb02e4b --- /dev/null +++ b/226/InvasionFront_CD3_block17_x6_y6_patient226_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 20489.2, + "Num Detections": 17831, + "Num Negative": 15317, + "Num Positive": 2514, + "Positive %": 14.1, + "Num Positive per mm^2": 1061.4 + } +} \ No newline at end of file diff --git a/226/InvasionFront_CD8_block17_x5_y6_patient226_0.json b/226/InvasionFront_CD8_block17_x5_y6_patient226_0.json new file mode 100644 index 0000000000000000000000000000000000000000..efe389c134cb4b915c23458e98a6a64a5f299e82 --- /dev/null +++ b/226/InvasionFront_CD8_block17_x5_y6_patient226_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 15416.8, + "Num Detections": 17359, + "Num Negative": 17286, + "Num Positive": 73, + "Positive %": 0.4205, + "Num Positive per mm^2": 31.64 + } +} \ No newline at end of file diff --git a/226/InvasionFront_CD8_block17_x6_y6_patient226_1.json b/226/InvasionFront_CD8_block17_x6_y6_patient226_1.json new file mode 100644 index 0000000000000000000000000000000000000000..863876159f790a8da521fb12b11523fcbf39d211 --- /dev/null +++ b/226/InvasionFront_CD8_block17_x6_y6_patient226_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 15591.7, + "Num Detections": 17407, + "Num Negative": 16563, + "Num Positive": 844, + "Positive %": 4.849, + "Num Positive per mm^2": 366.66 + } +} \ No newline at end of file diff --git a/226/TumorCenter_CD3_block17_x5_y6_patient226_0.json b/226/TumorCenter_CD3_block17_x5_y6_patient226_0.json new file mode 100644 index 0000000000000000000000000000000000000000..53772aa2f8355813969352859a43188c99f4f856 --- /dev/null +++ b/226/TumorCenter_CD3_block17_x5_y6_patient226_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 14942.1, + "Num Detections": 18880, + "Num Negative": 16446, + "Num Positive": 2434, + "Positive %": 12.89, + "Num Positive per mm^2": 1018.1 + } +} \ No newline at end of file diff --git a/226/TumorCenter_CD3_block17_x6_y6_patient226_1.json b/226/TumorCenter_CD3_block17_x6_y6_patient226_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2ae6907c69f2734aa61bdd9c0e187ede1cf361d1 --- /dev/null +++ b/226/TumorCenter_CD3_block17_x6_y6_patient226_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 15067.0, + "Num Detections": 13569, + "Num Negative": 12620, + "Num Positive": 949, + "Positive %": 6.994, + "Num Positive per mm^2": 476.57 + } +} \ No newline at end of file diff --git a/226/TumorCenter_CD8_block17_x5_y6_patient226_0.json b/226/TumorCenter_CD8_block17_x5_y6_patient226_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1d6db9bbe19a8b50e106153388231fe44f457554 --- /dev/null +++ b/226/TumorCenter_CD8_block17_x5_y6_patient226_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 28584.9, + "Num Detections": 19530, + "Num Negative": 19186, + "Num Positive": 344, + "Positive %": 1.761, + "Num Positive per mm^2": 148.37 + } +} \ No newline at end of file diff --git a/226/TumorCenter_CD8_block17_x6_y6_patient226_1.json b/226/TumorCenter_CD8_block17_x6_y6_patient226_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d552f8a131dfa82621a81830b0585f6affeb5985 --- /dev/null +++ b/226/TumorCenter_CD8_block17_x6_y6_patient226_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21563.6, + "Centroid Y µm": 28534.9, + "Num Detections": 16478, + "Num Negative": 16302, + "Num Positive": 176, + "Positive %": 1.068, + "Num Positive per mm^2": 79.07 + } +} \ No newline at end of file diff --git a/226/history_text.txt b/226/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6f6c5ed9d0157ea98db2aaf53d8d2c9907e920a7 --- /dev/null +++ b/226/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Histologically confirmed vocal fold carcinoma on the left side. \ No newline at end of file diff --git a/226/icd_codes.txt b/226/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..32e8a5f99cd47402d3bdc97fc9d33576205172b9 --- /dev/null +++ b/226/icd_codes.txt @@ -0,0 +1 @@ +Stimmbandkarzinom[C32.0 L] \ No newline at end of file diff --git a/226/ops_codes.txt b/226/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5b508f4d896241bc9f7875f26c433bfac8e53f15 --- /dev/null +++ b/226/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] \ No newline at end of file diff --git a/226/patient_clinical_data.json b/226/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..671f36f687f6c6742b1b5a60ae9d27a992b8a001 --- /dev/null +++ b/226/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/226/patient_pathological_data.json b/226/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e8e8f8eac6f77ddf44e3d1bed09191df3584b082 --- /dev/null +++ b/226/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "226", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/226/surgery_description.txt b/226/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..dea20c1fddc4582d98cc4130a5197aa42cca446a --- /dev/null +++ b/226/surgery_description.txt @@ -0,0 +1 @@ +Frontolateral partial laryngeal resection diff --git a/226/surgery_report.txt b/226/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..666a4302b204999184cb818a37bb10aae86feb0a --- /dev/null +++ b/226/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia colleagues. First of all, the larynx was again positioned and the tumor inspected. Although the tumor extends to the left arytenoid cartilage, it appears to be resectable in principle via a frontolateral partial laryngectomy, despite the fact that hyposclerosis of the left arytenoid cartilage is detectable on CT. Preoperative detailed discussion with the patient. Then repositioning of the patient. Application of local anesthesia above the laryngeal framework. Abjode and cover the surgical area. Now zigzag skin incision in the median line. Cut through the subcutaneous tissue. Cut through the muscles. Exposure of the linea alba and the infrahyoid musculature. Exposure of thyroid cartilage and ligamentum conicum. The patient has a large thyroid gland which extends to the cricoid cartilage. Based on this, expose the thyroid isthmus. Dissection of the thyroid isthmus and ligation of both halves of the thyroid gland. Exposure of the anterior wall of the trachea. Now cut through the conic ligament. Opening of the larynx with the wheel The tumor can be seen in the area of the left vocal fold, which extends to the anterior commissure, but obviously does not spread to the right side. The patient is now intubated and a tube is inserted into the trachea. The tumor is then cut around with a clear safety margin at the level of the vocal folds into the morgue sinus. The subglottic slope is also resected. Now dissect in the direction of the arytenoid cartilage. The vocal process of the arytenoid cartilage is included in the resection and the tumor is removed in the area of the posterior commissure. Several marginal samples are then taken, particularly in the posterior part, all of which are found to be histologically free of tumor. Tissue is removed from the area of the anterior third of the vocal fold on the right, which is also found to be tumor-free in the frozen section. Now careful hemostasis. Closure of the larynx and suturing of a Keel to prevent synechiae. Insertion of a flap. Wound closure in layers and application of a pressure bandage. Completion of the procedure. Final consultation with anesthesia colleagues. \ No newline at end of file diff --git a/227/InvasionFront_CD3_block12_x1_y11_patient227_0.json b/227/InvasionFront_CD3_block12_x1_y11_patient227_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bed211ae0192d1eb726875ed4b061ef1b4a2d952 --- /dev/null +++ b/227/InvasionFront_CD3_block12_x1_y11_patient227_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3198.3, + "Centroid Y µm": 31458.3, + "Num Detections": 17281, + "Num Negative": 16541, + "Num Positive": 740, + "Positive %": 4.282, + "Num Positive per mm^2": 354.08 + } +} \ No newline at end of file diff --git a/227/InvasionFront_CD3_block12_x2_y11_patient227_1.json b/227/InvasionFront_CD3_block12_x2_y11_patient227_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e4150396c6b5e5892404e43ffe034b2504667ce8 --- /dev/null +++ b/227/InvasionFront_CD3_block12_x2_y11_patient227_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 31658.2, + "Num Detections": 16708, + "Num Negative": 14876, + "Num Positive": 1832, + "Positive %": 10.96, + "Num Positive per mm^2": 820.79 + } +} \ No newline at end of file diff --git a/227/InvasionFront_CD8_block12_x1_y11_patient227_0.json b/227/InvasionFront_CD8_block12_x1_y11_patient227_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f585739740425708163f3a08654ab71bf3779896 --- /dev/null +++ b/227/InvasionFront_CD8_block12_x1_y11_patient227_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5463.3, + "Centroid Y µm": 31675.8, + "Num Detections": 18461, + "Num Negative": 18326, + "Num Positive": 135, + "Positive %": 0.7313, + "Num Positive per mm^2": 63.55 + } +} \ No newline at end of file diff --git a/227/InvasionFront_CD8_block12_x2_y11_patient227_1.json b/227/InvasionFront_CD8_block12_x2_y11_patient227_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e24481ac77e03cd894d0ee02aa8a305ce5b3b6cf --- /dev/null +++ b/227/InvasionFront_CD8_block12_x2_y11_patient227_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8045.7, + "Centroid Y µm": 31533.3, + "Num Detections": 17301, + "Num Negative": 16667, + "Num Positive": 634, + "Positive %": 3.665, + "Num Positive per mm^2": 286.56 + } +} \ No newline at end of file diff --git a/227/TumorCenter_CD3_block12_x1_y11_patient227_0.json b/227/TumorCenter_CD3_block12_x1_y11_patient227_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8b51c213e51c354e23ddfdc643b94d304e2724a9 --- /dev/null +++ b/227/TumorCenter_CD3_block12_x1_y11_patient227_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3298.3, + "Centroid Y µm": 26960.7, + "Num Detections": 17764, + "Num Negative": 16992, + "Num Positive": 772, + "Positive %": 4.346, + "Num Positive per mm^2": 348.58 + } +} \ No newline at end of file diff --git a/227/TumorCenter_CD3_block12_x2_y11_patient227_1.json b/227/TumorCenter_CD3_block12_x2_y11_patient227_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9bd63a2013c931d84502504e4078a494303d98be --- /dev/null +++ b/227/TumorCenter_CD3_block12_x2_y11_patient227_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5821.9, + "Centroid Y µm": 27010.7, + "Num Detections": 20387, + "Num Negative": 17965, + "Num Positive": 2422, + "Positive %": 11.88, + "Num Positive per mm^2": 1070.2 + } +} \ No newline at end of file diff --git a/227/TumorCenter_CD8_block12_x1_y11_patient227_0.json b/227/TumorCenter_CD8_block12_x1_y11_patient227_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5cbfd9d44e3f5cfa4d4873a45e68a5a0082e85b4 --- /dev/null +++ b/227/TumorCenter_CD8_block12_x1_y11_patient227_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 35906.0, + "Num Detections": 13345, + "Num Negative": 13138, + "Num Positive": 207, + "Positive %": 1.551, + "Num Positive per mm^2": 98.38 + } +} \ No newline at end of file diff --git a/227/TumorCenter_CD8_block12_x2_y11_patient227_1.json b/227/TumorCenter_CD8_block12_x2_y11_patient227_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8dfef73efd73b3fd243821ac6b1b86a5998a2814 --- /dev/null +++ b/227/TumorCenter_CD8_block12_x2_y11_patient227_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8620.4, + "Centroid Y µm": 36155.9, + "Num Detections": 15378, + "Num Negative": 14290, + "Num Positive": 1088, + "Positive %": 7.075, + "Num Positive per mm^2": 508.76 + } +} \ No newline at end of file diff --git a/227/history_text.txt b/227/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/227/icd_codes.txt b/227/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/227/ops_codes.txt b/227/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/227/patient_clinical_data.json b/227/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b096e9dcf67b417cbb7142b52f03cf8fe887baed --- /dev/null +++ b/227/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/227/patient_pathological_data.json b/227/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0dffdc43e6df5e4110aff84a89758264f8ab69e2 --- /dev/null +++ b/227/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "227", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/227/surgery_description.txt b/227/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2375c9467344efecc0f05d6a01bf246c5a7c636e --- /dev/null +++ b/227/surgery_description.txt @@ -0,0 +1 @@ +Partial tongue resection, Bilateral neck dissection, PEG placement diff --git a/227/surgery_report.txt b/227/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/228/InvasionFront_CD3_block4_x3_y9_patient228_0.json b/228/InvasionFront_CD3_block4_x3_y9_patient228_0.json new file mode 100644 index 0000000000000000000000000000000000000000..925f7274c8f99baca6f8100cb4124c7648b35a75 --- /dev/null +++ b/228/InvasionFront_CD3_block4_x3_y9_patient228_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 28534.9, + "Num Detections": 19049, + "Num Negative": 17412, + "Num Positive": 1637, + "Positive %": 8.594, + "Num Positive per mm^2": 767.49 + } +} \ No newline at end of file diff --git a/228/InvasionFront_CD3_block4_x4_y9_patient228_1.json b/228/InvasionFront_CD3_block4_x4_y9_patient228_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d621ae38791346f6484b5cd1e8e6225e55ac55e5 --- /dev/null +++ b/228/InvasionFront_CD3_block4_x4_y9_patient228_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 28709.8, + "Num Detections": 24458, + "Num Negative": 19311, + "Num Positive": 5147, + "Positive %": 21.04, + "Num Positive per mm^2": 2047.6 + } +} \ No newline at end of file diff --git a/228/InvasionFront_CD8_block4_x3_y9_patient228_0.json b/228/InvasionFront_CD8_block4_x3_y9_patient228_0.json new file mode 100644 index 0000000000000000000000000000000000000000..41cbec41db28728e0f8b04655152f199a8a9ed75 --- /dev/null +++ b/228/InvasionFront_CD8_block4_x3_y9_patient228_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 27335.5, + "Num Detections": 18170, + "Num Negative": 17034, + "Num Positive": 1136, + "Positive %": 6.252, + "Num Positive per mm^2": 532.62 + } +} \ No newline at end of file diff --git a/228/InvasionFront_CD8_block4_x4_y9_patient228_1.json b/228/InvasionFront_CD8_block4_x4_y9_patient228_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a21cf430931a243206baf951da31db6ddde03e6a --- /dev/null +++ b/228/InvasionFront_CD8_block4_x4_y9_patient228_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 27510.4, + "Num Detections": 18289, + "Num Negative": 13993, + "Num Positive": 4296, + "Positive %": 23.49, + "Num Positive per mm^2": 2125.3 + } +} \ No newline at end of file diff --git a/228/TumorCenter_CD3_block4_x3_y9_patient228_0.json b/228/TumorCenter_CD3_block4_x3_y9_patient228_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c9a3f5526ed632bf42eb0a9357248187785895b8 --- /dev/null +++ b/228/TumorCenter_CD3_block4_x3_y9_patient228_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 23087.8, + "Num Detections": 24495, + "Num Negative": 19393, + "Num Positive": 5102, + "Positive %": 20.83, + "Num Positive per mm^2": 1975.0 + } +} \ No newline at end of file diff --git a/228/TumorCenter_CD3_block4_x4_y9_patient228_1.json b/228/TumorCenter_CD3_block4_x4_y9_patient228_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2c9843d1820da6c99cc878675073e32bb1f0d763 --- /dev/null +++ b/228/TumorCenter_CD3_block4_x4_y9_patient228_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 23087.8, + "Num Detections": 15290, + "Num Negative": 14002, + "Num Positive": 1288, + "Positive %": 8.424, + "Num Positive per mm^2": 847.84 + } +} \ No newline at end of file diff --git a/228/TumorCenter_CD8_block4_x3_y9_patient228_0.json b/228/TumorCenter_CD8_block4_x3_y9_patient228_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f141061cf48af8d910b226bae38e05be1a433b61 --- /dev/null +++ b/228/TumorCenter_CD8_block4_x3_y9_patient228_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 22987.8, + "Num Detections": 23798, + "Num Negative": 18591, + "Num Positive": 5207, + "Positive %": 21.88, + "Num Positive per mm^2": 2010.9 + } +} \ No newline at end of file diff --git a/228/TumorCenter_CD8_block4_x4_y9_patient228_1.json b/228/TumorCenter_CD8_block4_x4_y9_patient228_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fc6aef99b121b9320cd768ddb2d98b794229f508 --- /dev/null +++ b/228/TumorCenter_CD8_block4_x4_y9_patient228_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 23112.8, + "Num Detections": 15773, + "Num Negative": 14268, + "Num Positive": 1505, + "Positive %": 9.542, + "Num Positive per mm^2": 964.07 + } +} \ No newline at end of file diff --git a/228/history_text.txt b/228/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/228/icd_codes.txt b/228/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/228/ops_codes.txt b/228/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..74af843baae29b22ef6c13845a695c3c580ba732 --- /dev/null +++ b/228/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Transplantat[5-296.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 B] Hemilaryngektomie horizontal supraglottisch mit Zungengrundresektion[5-301.1 ] Sonstige Temporäre Tracheostomie[5-311.x ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Entfernung vaskuläres Implantat Gefäße onA[5-394.4 ] Entfernung vaskuläres Implantat Gefäße onA[5-394.4 ] Revision Gefäßanastomose[5-394.1 ] \ No newline at end of file diff --git a/228/patient_clinical_data.json b/228/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f068cf36edeb25dad3946c36430c4e703dbebbec --- /dev/null +++ b/228/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/228/patient_pathological_data.json b/228/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f2c1683939ae0c1ee15d9aca9b59778981c86c32 --- /dev/null +++ b/228/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "228", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 10, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/228/surgery_description.txt b/228/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..aa5626ee65e7225492a83eaf423b56e277bb9f19 --- /dev/null +++ b/228/surgery_description.txt @@ -0,0 +1 @@ +Transcervical tumor resection, Neck dissection, Tracheotomy, Defect coverage, Free flap (Radial), Excision of part of the carotid artery by surgery diff --git a/228/surgery_report.txt b/228/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7e944028222f0636d2a75ced21e49071643baa7 --- /dev/null +++ b/228/surgery_report.txt @@ -0,0 +1 @@ +A PEG tube is inserted at the start of the operation. For this, insertion with the flexible gastroesophagoscope. Pre-viewing into the stomach. Then good diaphanoscopy. Insertion of the gastric tube using the thread pull-through method. This is successful without any problems. Induction of anesthesia and intubation by the anesthesia colleagues, then the tumor was inspected again with the Kleinsasser tube. The tumour is located in the hypopharynx on the lateral and anterior wall. It has a centrally deep ulcer, which is not accessible to the originally planned laser resection in any way, as the extension into the soft tissues of the neck cannot be determined and laser resection is therefore out of the question. Tracheotomy by . Palpation of the thyroid incisura, cricoid and jugulum as well as the anterior edge of the sternocleidomastoid and marking with a pen. Now mark the skin incision 3 transverse fingers above the jugulum, just below the cricoid cartilage. Make a horizontal incision along a skin fold, 7 cm long in total. Now enter with the 15 mm scalpel and sharply cut through the skin, the subcutaneous tissue and the platysma. The anterior jugular vein is now exposed. This vein is dissected, clamped, ligated and cut. Further dissection in depth with exposure of the infrahyoid musculature. The linea alba is dissected and the musculature is displaced to the side. The thyroid capsule is now exposed and the Overholt clamp is used to enter between the isthmus and the cricoid cartilage. The isthmus is undercut and bipolarized, coagulated and severed. There is no relevant bleeding. Now both thyroid lobes are pushed to the side and incision is made with the pointed scissors between the 2nd and 3rd tracheal cartilage ring. Creation of a Björk flap. Tracheostomy suture with Ethibond. Re-intubation of the patient to a 9 mm cannula. No complications. Then sterile washing and draping. Now start with the apron flap and neck dissection on the left side. A 20 x 15 cm metastasis is seen here, which completely infiltrates the cervical vascular sheath and the sternocleidomastoid muscle. Start with the dissection in the caudal area, here the sternocleidomastoid muscle is removed and the internal jugular vein is exposed, which is almost completely obliterated. Exposure of the common carotid artery from which the mass can still be pushed off in the deep part. This is very difficult as there is only a thin layer between the metastasis and the artery, which can, however, be dissected relatively well up to the bulb. The wall of the carotid artery is infiltrated in the area where the external carotid artery leaves, and the mass cannot be pushed off here. Further dissection in the cranial area. Separate the sternocleidomastoid muscle in the cranial region, then expose the obliterated internal jugular vein. This can also be removed. It is clear that the tumor is growing cranially to the base of the skull, then extremely laborious dissection of the metastasis from the base of the skull. This is finally successful. Now removal of the external carotid artery in the bulb area. However, the tumor must be left on the carotid artery, as it cannot be dissected off here. Removal of the entire metastasis. Now consult with , who recommends consulting a vascular surgeon with the question of a replacement graft. Now consult from the vascular surgery department. He sees no problem with an end-to-end anastomosis. As the carotid artery is elongated due to the tumor displacement, the bulb area can be resected with a safety margin. Plaque removal is now performed by and an end-to-end anastomosis is performed. Then transition to tumor resection. Entry into the pharynx from the lateral cranial side. Exposure of the tumor and resection of the tumor. The tumor grows clearly into the thyroid cartilage, so part of the thyroid cartilage is also removed. The superior laryngeal nerve must also be removed and the arytenoid on the left side can just be left standing. Now measure the defect and lift the radialis graft by . Neck dissection on the right by : elevation of a platysma flap together with . Successive dissection of the platysma and flaps of the platysma flap cranially. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the cervical vascular sheath and dissection of the internal jugular vein, the common carotid artery, the bifurcation as well as the external and internal carotid artery. Exposure and sparing of the vagus nerve and accessorius nerve. Displacement at the end of the operation. Re-embedding of the vagus and accessor nerve in the sense of a neurolysis. Exposure of the digaster venter posterior muscle. Exposure of the hypoglossal nerve and protection of the same. Displacement at the end of the operation. Re-embedding of the nerve in the sense of a neurolysis. Exposure of the right submandibular gland while protecting it. First develop the lateral neck preparation while sparing all the structures mentioned. The same applies to the median neck preparation. Postoperative careful hemostasis. During the operation, care was taken to preserve the venous and arterial connecting vessels. Elevation of the radialis graft by : Drawing of the radialis graft on the distal forearm (6 x 10 cm) with additional monitor in the area of the flap pedicle. Demonstration on . Skin incision on the proximal forearm with incision around the skin monitor and the entire radialis graft. Subcutaneous preparation between radialis graft and skin monitor. Incision of the forearm fascia and exposure of the flexor tendons. Subfascial preparation of the radialis graft, initially from the ulnar side, with safe protection of the ulnar artery. Particular care is taken to leave the peritendineum attached to the tendon. Identification of the distal section of the radial artery with the comitant veins. Radial incision of the deep forearm fascia lateral to the cephalic vein. Reliable identification of the external ramus of the radial nerve. Separation of the radial artery on the distal forearm. Elevation of the graft with constant vascular ligation using vascular clips of the perforator vessels. Exposure of the confluence in the area of the proximal forearm/elbow. A good venous vascular network can be seen. Visualization of the exit of the radial artery from the brachial artery. Safe removal first of the radial artery and then of the venous vessels. Completion of graft elevation without complications. Suturing of the graft and anastomosis of the vessels, for this the superior thyroid artery is used on the right side, on the left side there are no vessels except for the bare carotid artery. Unfortunately, in the case of a previous operation, only the external jugular vein is available as a connecting vessel, which is also used. The defect is closed with split skin from the right thigh through and . Inspection of the tendons for this. Some of these are very exposed and must be sutured over with muscle. Application of retaining sutures to reduce the defect. Adjustment of the split skin and suturing. Swabs are sutured onto areas where the split skin has no contact with the surface. At the end of the procedure, the skin is covered with a stretched compress and a dorsal forearm splint is applied. At the end, suture the skin monitor and insert a Redon drain on the left side and a flap on the right side. Insertion of the tracheostoma, two-layer wound closure and completion of the procedure without complications and good graft perfusion. In the meantime, the operation had to be interrupted several times as the patient developed a critical ventilation situation. This also necessitated an intraoperative bronchoscopy by the anesthesia colleagues. However, this did not reveal any pathological findings. Continue antibiotics for at least 24 hours, regular graft and wound checks according to the usual schedule. The patient is ventilated and admitted to the intensive care unit. The patient's circulation is unstable and he is in a critical pulmonary situation that requires close monitoring. \ No newline at end of file diff --git a/229/InvasionFront_CD3_block15_x5_y2_patient229_0.json b/229/InvasionFront_CD3_block15_x5_y2_patient229_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d89cdd172f72bff8d60c75554bf7c96a0bb9b9f6 --- /dev/null +++ b/229/InvasionFront_CD3_block15_x5_y2_patient229_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17765.6, + "Centroid Y µm": 14592.3, + "Num Detections": 17738, + "Num Negative": 17372, + "Num Positive": 366, + "Positive %": 2.063, + "Num Positive per mm^2": 162.59 + } +} \ No newline at end of file diff --git a/229/InvasionFront_CD3_block15_x6_y2_patient229_1.json b/229/InvasionFront_CD3_block15_x6_y2_patient229_1.json new file mode 100644 index 0000000000000000000000000000000000000000..293c4f70db4c4feb8f1693cb2a840000d2b06443 --- /dev/null +++ b/229/InvasionFront_CD3_block15_x6_y2_patient229_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20096.9, + "Centroid Y µm": 14429.0, + "Num Detections": 11059, + "Num Negative": 10718, + "Num Positive": 341, + "Positive %": 3.083, + "Num Positive per mm^2": 226.44 + } +} \ No newline at end of file diff --git a/229/InvasionFront_CD8_block15_x5_y2_patient229_0.json b/229/InvasionFront_CD8_block15_x5_y2_patient229_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a678fee9a1e97698d46295e56323b3f3f868645b --- /dev/null +++ b/229/InvasionFront_CD8_block15_x5_y2_patient229_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16081.3, + "Centroid Y µm": 4750.6, + "Num Detections": 15548, + "Num Negative": 15378, + "Num Positive": 170, + "Positive %": 1.093, + "Num Positive per mm^2": 81.6 + } +} \ No newline at end of file diff --git a/229/InvasionFront_CD8_block15_x6_y2_patient229_1.json b/229/InvasionFront_CD8_block15_x6_y2_patient229_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2ee07a23fb50e4bf9800825158fdf575fece384 --- /dev/null +++ b/229/InvasionFront_CD8_block15_x6_y2_patient229_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18707.7, + "Centroid Y µm": 4723.5, + "Num Detections": 11869, + "Num Negative": 11726, + "Num Positive": 143, + "Positive %": 1.205, + "Num Positive per mm^2": 77.45 + } +} \ No newline at end of file diff --git a/229/TumorCenter_CD3_block15_x5_y2_patient229_0.json b/229/TumorCenter_CD3_block15_x5_y2_patient229_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0d74c6bd0085b26e1a68c125238836534fe314fc --- /dev/null +++ b/229/TumorCenter_CD3_block15_x5_y2_patient229_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 8220.6, + "Num Detections": 17231, + "Num Negative": 16939, + "Num Positive": 292, + "Positive %": 1.695, + "Num Positive per mm^2": 136.3 + } +} \ No newline at end of file diff --git a/229/TumorCenter_CD3_block15_x6_y2_patient229_1.json b/229/TumorCenter_CD3_block15_x6_y2_patient229_1.json new file mode 100644 index 0000000000000000000000000000000000000000..374a5252728142ba2611adb20a85ccf1e9aedccb --- /dev/null +++ b/229/TumorCenter_CD3_block15_x6_y2_patient229_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 8220.6, + "Num Detections": 18527, + "Num Negative": 18236, + "Num Positive": 291, + "Positive %": 1.571, + "Num Positive per mm^2": 131.74 + } +} \ No newline at end of file diff --git a/229/TumorCenter_CD8_block15_x5_y2_patient229_0.json b/229/TumorCenter_CD8_block15_x5_y2_patient229_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d14ccc820a075b631b6e0cc43b1e8bf90a77ebbb --- /dev/null +++ b/229/TumorCenter_CD8_block15_x5_y2_patient229_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 5072.3, + "Num Detections": 16927, + "Num Negative": 16707, + "Num Positive": 220, + "Positive %": 1.3, + "Num Positive per mm^2": 107.52 + } +} \ No newline at end of file diff --git a/229/TumorCenter_CD8_block15_x6_y2_patient229_1.json b/229/TumorCenter_CD8_block15_x6_y2_patient229_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f49143c8b3334e7d9516d68bcdaf84698cba9311 --- /dev/null +++ b/229/TumorCenter_CD8_block15_x6_y2_patient229_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21388.7, + "Centroid Y µm": 4847.4, + "Num Detections": 19553, + "Num Negative": 19352, + "Num Positive": 201, + "Positive %": 1.028, + "Num Positive per mm^2": 93.27 + } +} \ No newline at end of file diff --git a/229/history_text.txt b/229/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/229/icd_codes.txt b/229/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b471b784d2b9d9c09a5a3b27210fcf133740a8a5 --- /dev/null +++ b/229/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 ] \ No newline at end of file diff --git a/229/ops_codes.txt b/229/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..daeeccbb500336815aebba6f8babfc38797a58c1 --- /dev/null +++ b/229/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument[1-620.1 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] Diagnostische Laryngoskopie direkt[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Sonstige permanente Tracheostomie[5-312.x ] Partielle Glossektomie transoral Rekonstruktion mit gestieltem regionalen Lappen[5-251.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 6 Regionen[5-403.22 L] \ No newline at end of file diff --git a/229/patient_clinical_data.json b/229/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fe30929ee0a45c861a92f7d7e9dbd8e573b7bf5d --- /dev/null +++ b/229/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/229/patient_pathological_data.json b/229/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bcb26a1acefdd59361ceb29d58397526da69b1f2 --- /dev/null +++ b/229/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "229", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/229/surgery_description.txt b/229/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..cb3d09cbafa4ea1f33d75b788f6eea049813bae7 --- /dev/null +++ b/229/surgery_description.txt @@ -0,0 +1 @@ +Partial resection of tongue and floor of mouth on the left, Neck dissection, Tracheostomy, PEG, Panendoscopy diff --git a/229/surgery_report.txt b/229/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..053d75b1a89f7515e6b4ae67ce7eca184d5e0689 --- /dev/null +++ b/229/surgery_report.txt @@ -0,0 +1 @@ +Start of surgery with tracheoscopy with unremarkable findings. Subsequently intubation and pharyngoscopy as well as laryngoscopy with the Kleinsasser tube (C-tube). An exulcerated tumor measuring approx. 4 x 2 cm was found in the area of the edge of the tongue and floor of the mouth on the left, from which a biopsy was taken for frozen section diagnosis. In addition, there is a leukoplakia behind the last molar on the left alveolar ridge of the mandible. The left tonsil also shows a discrete lesion, which is also biopsied. The previously described leukoplakia is removed by excisional biopsy. This is followed by esophagogastroscopy with a flexible instrument and placement of a PEG. After PEG placement without complications, enoral tumor resection is performed. Now the tumor is gradually bypassed with the monopolar needle at a macroscopic safety distance of 1 cm. As soon as the deep soft tissue gives way, a corresponding safety distance is maintained. The tumor extends from the anterior third of the tongue on the left over the entire dorsal edge of the tongue to approx. 1-2 cm into the base of the tongue. The tumor also reaches the glossotonsillar groove. After carefully moving around the tumor with the monopolar and removing the resected specimen, it is marked and sent for frozen section diagnostics. Neck dissection follows on the left side with a submandibular skin incision approx. 2 QF below the mandible and, after appropriate skin incision, preparation of the cranial and caudal platysmal flaps. Sparing of the external jugular vein and the auricularis magnus nerve. Dissection of the anterior edge of the sternocleidomastoid muscle up to the vascular nerve sheath. Dissection along the omohyoid muscle to the hyoid bone and along the diagstricus muscle to the laterobasis. Dissection along the internal jugular vein after previous exposure and securing of the accessorius nerve. Lifting of the level II, III and IV neck block while sparing all nerves and vascular structures. This is followed by the removal of level V with protection of the accessorius nerve, the cervical accessorius plexus and the cervical plexus. Enlarged lymph nodes are particularly evident in the area of level II. Level Va also shows enlarged lymph nodes in the cranial area. After careful removal of the corresponding regions, the submandibular gland is dissected and removed. The surrounding lymph nodes of region Ib are also carefully removed. Care is taken to protect the marginal ramus and facial nerve. Finally, the ligation of the lingual artery is performed due to the extensive partial resection of the enoral tongue. Irrigation of the wound, careful hemostasis and insertion of a 10-gauge Redon drain. Suturing of the platysma, subcutaneous sutures and skin sutures. After the frozen section has revealed submucosal carcinoma infiltrates, the corresponding areas are resected again and final margin samples are taken. These final margin samples now reveal a carcinoma-free finding in the frozen section diagnosis. Once again, careful hemostasis is carried out before a tracheostomy is performed due to the extensive resection area, the associated risk of swelling and bleeding and the predicted difficulty in swallowing. This involves a jugular skin incision and dissection of the subcutaneous tissue and prelaryngeal muscles. Dissection of the thyroid isthmus at the level of the cricoid cartilage. Undercutting of the isthmus and careful coagulation of the isthmus. Exposure of the anterior surface of the trachea, creation of a caudally pedicled suture in the sense of a Björk flap. Suturing of the Björk flap with 2 fixation sutures and a cranial suture of the stoma. Lateral skin sutures. Transfer to an 8-gauge Rüsch cannula with blocking. Sterile wound dressing. \ No newline at end of file diff --git a/230/InvasionFront_CD3_block2_x1_y10_patient230_0.json b/230/InvasionFront_CD3_block2_x1_y10_patient230_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac74b5df84024b2dddd0a24fcddca887a0a6a1be --- /dev/null +++ b/230/InvasionFront_CD3_block2_x1_y10_patient230_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6246.7, + "Centroid Y µm": 38554.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/230/InvasionFront_CD3_block2_x2_y10_patient230_1.json b/230/InvasionFront_CD3_block2_x2_y10_patient230_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4c936b0c6ceccea197e766b87da51b66204920a1 --- /dev/null +++ b/230/InvasionFront_CD3_block2_x2_y10_patient230_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8745.4, + "Centroid Y µm": 38429.7, + "Num Detections": 12190, + "Num Negative": 11991, + "Num Positive": 199, + "Positive %": 1.632, + "Num Positive per mm^2": 137.53 + } +} \ No newline at end of file diff --git a/230/InvasionFront_CD8_block2_x1_y10_patient230_0.json b/230/InvasionFront_CD8_block2_x1_y10_patient230_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d224c2334015704c3f2021d213a56d849e0f38bc --- /dev/null +++ b/230/InvasionFront_CD8_block2_x1_y10_patient230_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4847.4, + "Centroid Y µm": 25811.3, + "Num Detections": 18416, + "Num Negative": 18085, + "Num Positive": 331, + "Positive %": 1.797, + "Num Positive per mm^2": 147.73 + } +} \ No newline at end of file diff --git a/230/InvasionFront_CD8_block2_x2_y10_patient230_1.json b/230/InvasionFront_CD8_block2_x2_y10_patient230_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d293b006f4dda98905e39a501226b7b59e418fb6 --- /dev/null +++ b/230/InvasionFront_CD8_block2_x2_y10_patient230_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7571.0, + "Centroid Y µm": 25911.3, + "Num Detections": 18469, + "Num Negative": 18373, + "Num Positive": 96, + "Positive %": 0.5198, + "Num Positive per mm^2": 40.93 + } +} \ No newline at end of file diff --git a/230/TumorCenter_CD3_block2_x1_y10_patient230_0.json b/230/TumorCenter_CD3_block2_x1_y10_patient230_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a4755b1b6b343f1bb649828f91ae4fcc68b3fed0 --- /dev/null +++ b/230/TumorCenter_CD3_block2_x1_y10_patient230_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3573.1, + "Centroid Y µm": 24262.2, + "Num Detections": 14302, + "Num Negative": 14059, + "Num Positive": 243, + "Positive %": 1.699, + "Num Positive per mm^2": 130.99 + } +} \ No newline at end of file diff --git a/230/TumorCenter_CD3_block2_x2_y10_patient230_1.json b/230/TumorCenter_CD3_block2_x2_y10_patient230_1.json new file mode 100644 index 0000000000000000000000000000000000000000..27cc158bcf713841675ee56a451bf5c301085f68 --- /dev/null +++ b/230/TumorCenter_CD3_block2_x2_y10_patient230_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 24312.1, + "Num Detections": 14202, + "Num Negative": 13154, + "Num Positive": 1048, + "Positive %": 7.379, + "Num Positive per mm^2": 665.37 + } +} \ No newline at end of file diff --git a/230/TumorCenter_CD8_block2_x1_y10_patient230_0.json b/230/TumorCenter_CD8_block2_x1_y10_patient230_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b323846d1f363e8141901b63f243ae1533f178e1 --- /dev/null +++ b/230/TumorCenter_CD8_block2_x1_y10_patient230_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 24961.8, + "Num Detections": 8317, + "Num Negative": 8255, + "Num Positive": 62, + "Positive %": 0.7455, + "Num Positive per mm^2": 63.81 + } +} \ No newline at end of file diff --git a/230/TumorCenter_CD8_block2_x2_y10_patient230_1.json b/230/TumorCenter_CD8_block2_x2_y10_patient230_1.json new file mode 100644 index 0000000000000000000000000000000000000000..195e6b62ee89aebd5c2b0d85b49e16394581518b --- /dev/null +++ b/230/TumorCenter_CD8_block2_x2_y10_patient230_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8645.4, + "Centroid Y µm": 24736.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/230/history_text.txt b/230/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/230/icd_codes.txt b/230/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/230/ops_codes.txt b/230/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..72b597d02dd331e595d092b91e1dabe4218bf1aa --- /dev/null +++ b/230/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Permanente Tracheotomie[5-312.0 ] Extraktion mehrwurzeliger Zahn[5-230.1 ] \ No newline at end of file diff --git a/230/patient_clinical_data.json b/230/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..584729872dfc22d661000358f04a8633e6625158 --- /dev/null +++ b/230/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/230/patient_pathological_data.json b/230/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..11f2ca5f3009bf5a4341346b3a96095b532dc87c --- /dev/null +++ b/230/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "230", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/230/surgery_description.txt b/230/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..740a78ca42b86f3ca1358a6634911d951162be53 --- /dev/null +++ b/230/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Neck dissection, and Tracheotomy diff --git a/230/surgery_report.txt b/230/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a1b570a02359168fd9b08c337d1a1a6cbb2e5ec0 --- /dev/null +++ b/230/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Positioning of the patient. Repeated panendoscopy: The previously described tumor of the right tongue base is seen, which appears to extend to the oropharyngeal side wall as well as the glossotonsillar groove and the mandible. The mandible is certainly not infiltrated in the CT scan. However, the tumor extends somewhat laterally behind the mandible. Insertion of the oral retractor and removal of the arm, as flap reconstruction is to be expected here. The tumor is then removed from the anterior palatal arch paramedian to the uvula and dissected laterally and caudally. Dissection is carried out in the base of the tongue up to the midline. Dissection is carried out with an electric needle and scissors. It can be seen that the tumor extends to the lateral oropharyngeal wall as suspected and reaches the posterior mandible. Here the dissection extends into the fatty tissue. In the end, however, the vessels can no longer be controlled here, so that it is now necessary to switch to further dissection of the transcervical area. The patient is therefore draped and repositioned. Incision along the anterior edge of the sternocleidomastoid muscle. Dissection of the omohyoid muscle and the digaster muscle. Exposure of the cervical vascular sheath. This is then opened in an elongated manner. Long dissection of the vagus nerve. Exposure of the accessorius nerve. This is also dissected over a long distance, lifted out of its bed and dissected free in the sense of a neurolysis. Re-embedding of the nerves. Then insertion of retractors and preparation of the lateral neck preparation of levels II, III, IV and V. Here preparation of level I b with long-distance preparation as well as neurolysis and re-embedding of the hypoglossal nerve. Complete the anterior neck preparation so that the neck dissection of levels II to V is finally completed here. The posterior digaster venter muscle and the stylohyoid muscle are then dissected to allow wide access to the pharynx. It can be seen that the tumor can be palpated far ventrally in the tongue. Therefore, a submandibulectomy with ligation of the excretory duct was performed. Here, the hypoglossal nerve and the lingual nerve are dissected again over a long distance. The latter is also removed from its bed by neurolysis and re-embedded. Then open the pharynx and expose the tumor caudally. Subsequently, further dissection of the tumor combined transcervically and transorally. The tumor has a cone that extends deep into the base of the tongue and into the posterior floor of the mouth. Finally, under extremely difficult preparation conditions, with limited mouth opening, the tumor can be fully developed. Subsequently, marginal samples are taken from the palatal arch and the medial margin of the base of the tongue, the lateral margin and the anterior margin. It can be seen that tumor is still present in the lateral deposition area in the frozen section. The tumor extends here over the glossotonsillar groove to the alveolar ridge. The mucosa is pushed away from the horizontal part of the alveolar ridge and the ascending mandible. The entire flank medial to the ascending mandible is exposed. Grinding of the bone. Removal of marginal samples again. These also show renewed infiltrate of invasive carcinoma. Therefore decision to remove the last molar, to which the tumor now seems to reach. This represents a bridge reconstruction of the posterior molars, so that the bridge must be removed first. Then extraction of the last molar. Careful grinding of the lower jaw and the alveolus. Removal of a new marginal sample in front of the last molar, which is also assessed as tumor-free in the frozen section. This results in a current R0 resection of the tumor. In the meantime, lifting of the radial lobe in a typical manner. To do this, first assess the tumor resection defect. Modeling of an individual flap, which is then transferred to the distal forearm. Vascular check again. Start dissection on the ulnar side while protecting the long-distance dissection and displacing the ulnar nerve. Dissection of the distal end and another careful vascular check with pulse oximetry. A good ulnar peripheral supply can be seen here, so that after exposing the radial artery, this can be removed distally. Further development of the flap on the radial side. Dissection of the flap proximally with dissection of the proximal flap pedicle. Dissection is performed up to the elbow at the confluence of the deep and superficial venous system. The entire vein star is removed here. Separation of the artery. Subsequent modeling of the flap, which is painstakingly sutured in place transorally using sutures. Passing the vascular pedicle through the pharyngeal defect. After complete circular suturing, dissection of the neck vessels and exposure of the lingual artery. This is ligated to reduce bleeding. Exposure of the thyroid as well as the V. facialis and V. thyroidea media. The flap is anastomosed to these vessels with two veins and an artery. The venous anastomosis is performed with couplers, the arterial anastomosis with single button sutures. There is very good flow in all vessels. The flap appears pink. Therefore, insertion of wound flaps and subsequent two-layer wound closure. On the thigh, removal of split skin with a thickness of 0.8 mm with the dermatome with a width of 8 cm. The split skin graft is about 9 cm long. Then wound care using a non-adherent wound dressing. Treatment of the lifting defect of the radialis flap on the distal forearm and closure of the incision for vascular pedicle harvesting. Circular suturing of the split-thickness skin graft. Making several relief incisions in the skin graft. Then adjustment and application of a VAC dressing, which should be changed between the 5th and 7th postoperative day. Performing a permanent tracheostomy. Also extremely difficult preparation conditions with a short neck and high sternum. The incision is made as for the Kocher collar incision. Dissection in layers in depth after cutting through the platysma. Separate the infralaryngeal musculature and pretracheal musculature in the median line. Exposure of the thyroid isthmus. This is undermined and then severed after careful coagulation. Exposure of the anterior wall of the trachea. Exposure of the 2nd and 3rd cartilage clasp. Opening of the trachea between these two cartilage clasps and subsequent preparation of a Björ flap. Then circular suturing of the tracheostoma with mucocutaneous anastomosis. Insertion of a size 7 tracheostomy tube, which is fixed in place with sutures. Due to the difficult tracheostoma, the cannula should not be changed until the 5th postoperative day, but only suctioned out. Final consultation with the anesthetist. Transfer of the patient to the in-house intensive care unit. \ No newline at end of file diff --git a/231/InvasionFront_CD3_block3_x3_y5_patient231_0.json b/231/InvasionFront_CD3_block3_x3_y5_patient231_0.json new file mode 100644 index 0000000000000000000000000000000000000000..483fab1418e9453b6b3f84576ff83529c1c82021 --- /dev/null +++ b/231/InvasionFront_CD3_block3_x3_y5_patient231_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13158.4, + "Centroid Y µm": 17784.8, + "Num Detections": 18553, + "Num Negative": 16728, + "Num Positive": 1825, + "Positive %": 9.837, + "Num Positive per mm^2": 784.59 + } +} \ No newline at end of file diff --git a/231/InvasionFront_CD3_block3_x4_y5_patient231_1.json b/231/InvasionFront_CD3_block3_x4_y5_patient231_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a9eb5e953b40e3251893a076a76a4bb3ea891de0 --- /dev/null +++ b/231/InvasionFront_CD3_block3_x4_y5_patient231_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15666.7, + "Centroid Y µm": 17865.5, + "Num Detections": 19426, + "Num Negative": 18147, + "Num Positive": 1279, + "Positive %": 6.584, + "Num Positive per mm^2": 548.42 + } +} \ No newline at end of file diff --git a/231/InvasionFront_CD8_block3_x3_y5_patient231_0.json b/231/InvasionFront_CD8_block3_x3_y5_patient231_0.json new file mode 100644 index 0000000000000000000000000000000000000000..16f0e2a74d5c2b5da90b37486aba67ab169a3506 --- /dev/null +++ b/231/InvasionFront_CD8_block3_x3_y5_patient231_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12489.4, + "Centroid Y µm": 12335.8, + "Num Detections": 14007, + "Num Negative": 12206, + "Num Positive": 1801, + "Positive %": 12.86, + "Num Positive per mm^2": 933.49 + } +} \ No newline at end of file diff --git a/231/InvasionFront_CD8_block3_x4_y5_patient231_1.json b/231/InvasionFront_CD8_block3_x4_y5_patient231_1.json new file mode 100644 index 0000000000000000000000000000000000000000..86d5cb055724dbb98d602e95a1c2e1012b97fdc0 --- /dev/null +++ b/231/InvasionFront_CD8_block3_x4_y5_patient231_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15026.6, + "Centroid Y µm": 12297.6, + "Num Detections": 15960, + "Num Negative": 15084, + "Num Positive": 876, + "Positive %": 5.489, + "Num Positive per mm^2": 396.94 + } +} \ No newline at end of file diff --git a/231/TumorCenter_CD3_block3_x3_y5_patient231_0.json b/231/TumorCenter_CD3_block3_x3_y5_patient231_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b37b40cbbf935dc6adcd5dc03d36d81616e94246 --- /dev/null +++ b/231/TumorCenter_CD3_block3_x3_y5_patient231_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10956.6, + "Centroid Y µm": 18773.6, + "Num Detections": 17227, + "Num Negative": 13406, + "Num Positive": 3821, + "Positive %": 22.18, + "Num Positive per mm^2": 1725.3 + } +} \ No newline at end of file diff --git a/231/TumorCenter_CD3_block3_x4_y5_patient231_1.json b/231/TumorCenter_CD3_block3_x4_y5_patient231_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ea67e77152450b7b35158bd990bfa293dd0babd6 --- /dev/null +++ b/231/TumorCenter_CD3_block3_x4_y5_patient231_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13577.0, + "Centroid Y µm": 18699.6, + "Num Detections": 17716, + "Num Negative": 15275, + "Num Positive": 2441, + "Positive %": 13.78, + "Num Positive per mm^2": 1094.8 + } +} \ No newline at end of file diff --git a/231/TumorCenter_CD8_block3_x3_y5_patient231_0.json b/231/TumorCenter_CD8_block3_x3_y5_patient231_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c5085f898a9dea6ce965d6521aa74d46f2f90ca6 --- /dev/null +++ b/231/TumorCenter_CD8_block3_x3_y5_patient231_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11993.6, + "Centroid Y µm": 13917.6, + "Num Detections": 18156, + "Num Negative": 16838, + "Num Positive": 1318, + "Positive %": 7.259, + "Num Positive per mm^2": 592.94 + } +} \ No newline at end of file diff --git a/231/TumorCenter_CD8_block3_x4_y5_patient231_1.json b/231/TumorCenter_CD8_block3_x4_y5_patient231_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e50384e15cb052d3ee01907775afbea08aad224 --- /dev/null +++ b/231/TumorCenter_CD8_block3_x4_y5_patient231_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14567.3, + "Centroid Y µm": 14042.6, + "Num Detections": 19026, + "Num Negative": 17663, + "Num Positive": 1363, + "Positive %": 7.164, + "Num Positive per mm^2": 629.06 + } +} \ No newline at end of file diff --git a/231/history_text.txt b/231/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..bc4e2b5a228a6d8d85949897a327772e6b1c4a00 --- /dev/null +++ b/231/history_text.txt @@ -0,0 +1 @@ +The patient has had difficulty swallowing for many weeks. <2016> an extensive tumor debulking was performed as part of a panendo. After a decision in the tumor conference and consultation with the patient and her caregiver, recommendation for surgical therapy. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/231/icd_codes.txt b/231/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..475c751f4718dbb598608efc3a9c5bbc032d54d4 --- /dev/null +++ b/231/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/231/ops_codes.txt b/231/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..714fbe7ac469a9f1b5c937337e6770b9abc11511 --- /dev/null +++ b/231/ops_codes.txt @@ -0,0 +1 @@ +mikrovaskulär-anastomosierten Transplantat[5-295.24 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Partielle Exzision [erkrankter] harter und weicher Gaumen[5-272.1 ] Partielle Glossektomie durch Pharyngotomie sonstige[5-251.2x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 R] Permanente Tracheotomie[5-312.0 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 R] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/231/patient_clinical_data.json b/231/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6205d21e5b11c4f3de6e97b33000e5c54f2f1f4f --- /dev/null +++ b/231/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 72, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 48, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/231/patient_pathological_data.json b/231/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2f463958e87677484a57f5810f755785437b2973 --- /dev/null +++ b/231/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "231", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 62, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/231/surgery_description.txt b/231/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..40aba54435b91820d5460eeca3d6f7f8f3add976 --- /dev/null +++ b/231/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Panendoscopy, Free flap coverage (Radial) diff --git a/231/surgery_report.txt b/231/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..91a1bfb7c4ef3afd275434a9a453ffe56308b1c4 --- /dev/null +++ b/231/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues transnasally. Then start of the tumor resection from the transoral side. Insertion of a tonsil plug and inspection of the oropharynx and oral cavity. A relatively fresh lesion with irregular mucosal changes is found in the area of the uvula. As it cannot be guaranteed whether this lesion existed previously or was caused by the intubation, a biopsy is taken and sent for a frozen section. No evidence of dysplasia or invasive carcinoma in the frozen section. Therefore, start with tumor resection. The tumor extends onto the soft palate and moves along the alveolar ridge of the mandible into the tonsil region, infiltrates and completely consumes the tonsil, continues down the lateral wall of the oropharynx on the left and spreads to the base of the tongue here, infiltrates the base of the tongue on the right side, merges into the vallecula. The epiglottis is free. Now start with the tumor resection in the area of the soft palate, here macroscopic safety distance approx. 1 cm. The tumor is cut around with the monopolar needle. The tumor resection is now extended to the alveolar ridge. The tumor also infiltrates the posterior palatal arch. This is removed as well as part of the pharynx. The area of the cervical fat is reached relatively quickly and since the overview in the caudal area is no longer given, the tumor is now washed and covered sterilely in order to continue the tumor resection later from the transcervical area. Now make a skin incision at the anterior margin of the sternocleidomastoid muscle. Exposure of the anterior margin of the sternocleidomastoid muscle. Here you can already see large metastases in level II. Visualization of the omohyoid muscle, visualization of the cervical vascular sheath. It is clear that the internal jugular vein is infiltrated by a large metastasis at level III, so the internal jugular vein is removed below this metastasis. The neck levels IIa to Va are then cleared out, sparing the plexus branches. The neck levels are sent separately for histology as part of the lymph node study. Level Ia and b are then evacuated with removal of the submandibular gland and transection of the digastric and stylohyoid muscles. Level I also contains conspicuous nodes, which are all removed. A breakthrough is now created enorally and the tumor is removed via this breakthrough using the pull-through technique. Marginal samples are taken from the tumor specimen itself and sent for frozen section; all marginal samples are tumor-free. This means that the tumor itself is removed from the R0 specimen. Now measure the defect and move on to the radialis graft. Start by elevating the radialis graft with , then continue with , at the same time carry out the neck dissection on the right side with , here also making a skin incision on the anterior edge of the sternocleidomastoid muscle. Exposure of the platysma, exposure of the omohyoid and the sternocleidomastoid muscle. Exposure of the cervical vascular sheath and clearing of the neck levels IIa to Va while sparing the plexus branches. Here too, the neck levels are sent in individually as part of the lymph node study. The vascular situation here is also relatively poor. There is only a tiny superior thyroid artery, which is not suitable for subsequent connection to the radial artery. The lingual artery cannot be removed as it had to be resected on the left side as part of the tumor resection. The ascending pharyngeal artery is so small that it is also not available as a flap vessel. Only a very small facial artery would be possible. There is also only one vein available as a venous connecting vessel, namely the facial vein, which is also very thin. Dictation of the radial artery flap. Marking of the graft 14 x 6 x 6 cm is configured so that both the pharyngeal and soft palate defect can be covered, as well as the tongue base defect. Incision of the graft. Incision in the proximal area of the forearm. Then exposure of the brachioradialis muscle. Exposure of the superficial fascia of the radial nerve, which can be completely spared with its branches. Exposure of the radial artery. Clamping, ligation and ligation of the radial artery, then lifting of the radialis graft from the tendon bed. The ulnar artery is palpable in depth. Pulse oximetry on the index finger shows a continuous good blood supply to the hand, even after the radial artery has been removed. Then dissection of the pedicle up to the elbow. This shows an anatomical variation, so that the radial artery is dissected further up into the upper arm area and can only be removed at its high exit. Two venous vessels are also elevated, both of which belong to the superficial system, but a very good confluence between the superficial and deep venous system can also be elevated. The radialis graft is then removed. It can now be seen that one superficial vein has no venous return flow and the second vein only has a weak return flow. Overall, it can be seen that the entire radial artery is also in a very poor condition in terms of the endothelium. Nevertheless, there is no further possibility of lifting another graft. This graft must be used. This is also due to the fact that the left side is not available as a graft in the absence of sufficient perfusion in the radial artery area and the AED is also not suitable for use in the case of severe obesity. Suturing the graft first from the transoral side and then later from the transoral side is again difficult due to swelling. Sutures must therefore be placed in the caudal area and the graft retracted. Now create an opening from the cervical left to the cervical right. The stalk is then transferred to the right side. Dissect the facial artery as the connecting vessel and the facial vein. Then first suture the arterial anastomosis. Good flap perfusion at the beginning. However, the venous return flow is then interrupted so that the entire arterial anastomosis has to be sutured again. This condition then occurs again, so that up to a third anastomosis must be made in the arterial limb. For this, large sections of the radial artery have to be cut back and also the facial artery due to the very poor vascular condition in the vessel itself, there are endothelial-like deposits both in the neck and in the radial artery, some of which are calcareous, which makes suturing the anastomosis considerably more difficult. Ultimately, good flap perfusion can be maintained over a longer period of time with an albeit limited, moderate venous return flow. The facial vein is now connected to the one remaining flap vein using a coupler. Due to an unfavorable flap situation, this has to be repeated so that ultimately extremely difficult conditions exist in the anastomosis area, but a stable anastomosis could be created at the end of the operation. Due to the special situation, the patient was given 500 E/h heparin intraoperatively, which was to continue for 5 days. At the end, a flap was inserted on the right side and a Redon drainage on the left side. Prior to this, a tracheotomy was performed in the usual manner and the neck was closed in two layers. The patient was admitted to the intensive care unit on mechanical ventilation. Continue antibiotics for at least 24 hours, preferably for 3 days. Then 5 days heparin 500 E/h, for 2 days please 2-hourly flap controls, then continue according to the usual scheme and present the patient to the tumor conference after receiving the histology. \ No newline at end of file diff --git a/232/InvasionFront_CD3_block16_x3_y1_patient232_0.json b/232/InvasionFront_CD3_block16_x3_y1_patient232_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8b518df33388a3379befafcc745553e07ed35bfe --- /dev/null +++ b/232/InvasionFront_CD3_block16_x3_y1_patient232_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11820.4, + "Centroid Y µm": 7018.9, + "Num Detections": 17919, + "Num Negative": 17498, + "Num Positive": 421, + "Positive %": 2.349, + "Num Positive per mm^2": 176.61 + } +} \ No newline at end of file diff --git a/232/InvasionFront_CD3_block16_x4_y1_patient232_1.json b/232/InvasionFront_CD3_block16_x4_y1_patient232_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ad8dd1d201c5bbed13dafa052ca642121b73d1b3 --- /dev/null +++ b/232/InvasionFront_CD3_block16_x4_y1_patient232_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14481.4, + "Centroid Y µm": 6982.4, + "Num Detections": 16265, + "Num Negative": 15987, + "Num Positive": 278, + "Positive %": 1.709, + "Num Positive per mm^2": 116.99 + } +} \ No newline at end of file diff --git a/232/InvasionFront_CD8_block16_x3_y1_patient232_0.json b/232/InvasionFront_CD8_block16_x3_y1_patient232_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7ffbe27b87f84d20591abb590f8f2b6a5c75e713 --- /dev/null +++ b/232/InvasionFront_CD8_block16_x3_y1_patient232_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11285.9, + "Centroid Y µm": 2617.0, + "Num Detections": 19954, + "Num Negative": 19805, + "Num Positive": 149, + "Positive %": 0.7467, + "Num Positive per mm^2": 61.58 + } +} \ No newline at end of file diff --git a/232/InvasionFront_CD8_block16_x4_y1_patient232_1.json b/232/InvasionFront_CD8_block16_x4_y1_patient232_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9adfcac0f0f323b545cc78a4be16df3416e11a0 --- /dev/null +++ b/232/InvasionFront_CD8_block16_x4_y1_patient232_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13983.2, + "Centroid Y µm": 2739.5, + "Num Detections": 20264, + "Num Negative": 20171, + "Num Positive": 93, + "Positive %": 0.4589, + "Num Positive per mm^2": 36.98 + } +} \ No newline at end of file diff --git a/232/TumorCenter_CD3_block16_x3_y1_patient232_0.json b/232/TumorCenter_CD3_block16_x3_y1_patient232_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c0e35e206c01feb9d56d1033326277a19570befc --- /dev/null +++ b/232/TumorCenter_CD3_block16_x3_y1_patient232_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12593.3, + "Centroid Y µm": 2673.6, + "Num Detections": 8024, + "Num Negative": 7794, + "Num Positive": 230, + "Positive %": 2.866, + "Num Positive per mm^2": 206.81 + } +} \ No newline at end of file diff --git a/232/TumorCenter_CD3_block16_x4_y1_patient232_1.json b/232/TumorCenter_CD3_block16_x4_y1_patient232_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f02a6f0ca52400798830d67c6447ec152506b9b3 --- /dev/null +++ b/232/TumorCenter_CD3_block16_x4_y1_patient232_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14967.1, + "Centroid Y µm": 2773.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/232/TumorCenter_CD8_block16_x3_y1_patient232_0.json b/232/TumorCenter_CD8_block16_x3_y1_patient232_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d64ae2e731300d541204a0cedb64ea21619d77c --- /dev/null +++ b/232/TumorCenter_CD8_block16_x3_y1_patient232_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11094.1, + "Centroid Y µm": 2648.6, + "Num Detections": 12240, + "Num Negative": 12208, + "Num Positive": 32, + "Positive %": 0.2614, + "Num Positive per mm^2": 20.88 + } +} \ No newline at end of file diff --git a/232/TumorCenter_CD8_block16_x4_y1_patient232_1.json b/232/TumorCenter_CD8_block16_x4_y1_patient232_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e51db5254e34e92cc813501bb77b83461f28e58c --- /dev/null +++ b/232/TumorCenter_CD8_block16_x4_y1_patient232_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 2673.6, + "Num Detections": 4640, + "Num Negative": 4628, + "Num Positive": 12, + "Positive %": 0.2586, + "Num Positive per mm^2": 22.24 + } +} \ No newline at end of file diff --git a/232/history_text.txt b/232/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6f74e323ee6568ede42158a0fc25a1c2e9edcc9c --- /dev/null +++ b/232/history_text.txt @@ -0,0 +1 @@ +Mr. has an exophytic mass on the left edge of the tongue with infiltration of the base of the tongue and simultaneous N2a neck status on the left side. Therefore indication for the above mentioned operation. \ No newline at end of file diff --git a/232/icd_codes.txt b/232/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b70d39d40182f6b0659154167eba911cfdd8091f --- /dev/null +++ b/232/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/232/ops_codes.txt b/232/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..04eadcf7fe83d4112a9bcf6ca1d9e25b7969fadb --- /dev/null +++ b/232/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 B] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Destruktion: Elektrokoagulation[5-250.30 ] Partielle Glossektomie: Transoral: Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.02 ] Patchplastik Arterien Kopf und Hals extrakraniell A. carotis externa[5-395.03 L] Entnahme freier Radialis-Lappen[5-858.23 L] \ No newline at end of file diff --git a/232/patient_clinical_data.json b/232/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..52065efcba5d9ac128d5fc1046ac2e95de4413fa --- /dev/null +++ b/232/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 53, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/232/patient_pathological_data.json b/232/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7f9c25aa306fa5a6eea5d76d0275d4bda23d50d3 --- /dev/null +++ b/232/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "232", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/232/surgery_description.txt b/232/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..77f5a8346bd75f79902955d5854ffcc316020557 --- /dev/null +++ b/232/surgery_description.txt @@ -0,0 +1 @@ +Intraoral tumor resection, Neck dissection, Radial forearm flap, Tracheotomy, PEG placement diff --git a/232/surgery_report.txt b/232/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a72574545e8e909ced32eb2acac909d4fd24a7cd --- /dev/null +++ b/232/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and nasotracheal intubation from anesthesia, pharyngoscopy and inspection of the oral cavity are performed. Apart from the 4.5 cm exophytic tumor described above, which stops just before the midline of the tongue, there are no other abnormalities. Now flexible esophagogastroscopy and placement of the PEG tube in the typical manner using the thread pull-through method after positive diaphanoscopy. Now proceed to enoral tumor resection. The tongue is retracted and the retractor inserted. Then, using the electric needle, the tongue is cut approx. 2 cm from the tip from anterior to posterior. A safety distance of 1 cm to 1.5 cm is maintained. The muscle tissue is carefully removed from the tumor in depth. However, a cone can be seen medially, which is cut very closely. Further dissection posteriorly. Here the transition at the base of the tongue just past the midline and then resection of the glossotonsillar groove up to the lower pole of the tonsil. Laterally, the resection extends to the floor of the mouth, but does not reach the alveolar ridge. Now the entire preparation is sent for frozen section diagnostics and a small resection is also made at the lateral margin at a point that is questionable. The frozen section examination then shows that the medial situation is R1, otherwise there are no further abnormalities at the other margins. Therefore, a 5 mm thick strip is resected from the medial side with the help of scissors. This is divided into two parts, one anterior medial and one posterior medial. Both are found to be tumor-free. At the end, the defect is measured. This measures approximately 10 cm x 6 cm in size. Now proceed to neck dissection of both sides and tracheotomy. The left side is shown here first. The sternocleidomastoid muscle, digastric muscle, omohyoid muscle, internal jugular vein from caudal to cranial and also the facial vein and sparing of the latter. Also sparing of the external jugular vein. Form the lateral neck preparation from cranial to caudal, sparing the plexus branches and the accessorius nerve. Then form the medial neck preparation while protecting the hypoglossal nerve. Then resect the digastric muscle so that the perforation to the oral cavity is formed. Now proceed to the neck dissection on the right side. Identical procedure here. Identify the sternocleidomastoid muscle, digastric muscle, omohyoid muscle, free the internal jugular vein, form the lateral neck preparation while protecting the accessorius nerve and plexus branches, then also the medial neck preparation while protecting the hypoglossal nerve and submandibular gland. Now repositioning for tracheotomy. Horizontal incision here. Dissection of the subcutaneous tissue and platysma. Exposure of the pretracheal musculature and spreading of the latter. Identification of the cricoid cartilage, undermining of the thyroid gland, opening of a small window on the trachea between the 2nd and 3rd tracheal ring and reintubation on a Woodbridge tube into the trachea. Now proceed to elevate the free radialis graft on the left side: First mark the 10 cm x 6 cm graft in the caudal forearm area so that the cephalic veins are included and the flap as a whole has a radial tendency. Then draw the incision up to the elbow. Now first cut around the flap and extend the incision to the elbow. Then carefully dissect the subcutaneous area superficial to the cephalic vein using Stevens scissors. This, together with its fat pad, is now placed laterally to the brachioradialis muscle at the border of this fat pad. Now first dissect the ulnar side of the graft to secure the ulnar artery. Dissect deep down to the musculature. In particular, dissection along the tendons of the palmaris longus and flexor carpi radialis. Both are left with a minimal layer of fat on top. Now change sides and dissect the radial side again. First follow the brachioradialis muscle. In the caudal area, identify and protect the radial ramus superficialis nerve. In addition, the cephalic vein is dissected caudally and included in the graft. Now form the peripheral side of the graft. Identify the radial artery here. First clamp the last one with the bulldog for 10 minutes. A drop in saturation cannot be identified in the area of the index finger, so the radial artery is then ligated with veins. Now the deep side of the tendon of the brachioradialis muscle is removed from the graft, then dissected along the vessels of the graft (radial artery with two accompanying veins). The perforators of the vascular bundle in the direction of the deep musculature and pronator teres muscle are then successively partially bipolized and partially removed with clamps. Further cranially, the radial artery is now followed very carefully. The confluence of both accompanying veins in the deep venous system is identified and the anostomosis of the deep venous system to the cephalic vein is dissected and protected. The antebrachial cephalic vein is seen to branch into a very beautiful cephalic vein in the upper arm region and a basilic vein. Both are further dissected to a length of approx. 3 cm and then separated. At the same time, the radial artery is followed up to the bifurcation with the ulnar artery. The ulnar artery is then digitally pressed, causing the pulse on the pulse oximeter to disappear. This provides a second confirmation of the ulnar vein. The radial artery is now also removed 1 cm before this outlet. Now flush the radial artery with heparin until it comes out of the veins. Then place the radial artery graft in warm water. A large graft of split skin is then removed from the right thigh. The thigh is then covered with Opsite sheets. The split-thickness skin graft is then used to cover the defect on the left forearm. A VAC dressing is not used, but a forearm splint is sutured again with Mepilex under considerable pressure. The radialis graft is now sutured very carefully to the edge of the tongue, from anterior to posterior. Suturing the base of the tongue is quite difficult here. The vessels are then freed of fibrin again on the left neck and the superior thyroid artery is further dissected to a length of approx. 5 cm and then removed. The latter shows a lumen that is smaller than the radial artery, which is why it is incised obliquely and then sutured microscopically using 8-0 ethilon sutures. After opening the micro-staples, the suture is found to be insufficient. This is then repaired with additional sutures. It is now apparent that sufficient blood is coming out of the venous end of the radialis graft. For this reason, the cephalic vein is then anastomosed with the facial vein using the coupler system. At the end of the operation, placement of a flap on the left side and a Redon drainage on the right side and transfer of the patient tracheotomized and ventilated to the intensive care unit. The patient should continue to receive antibiotics for at least 3 days and should only be fed via the PEG. The flap should be checked every two hours and the first cannula change should take place on day 5. The patient has a heparin perfusor running at 500 units per hour after the anastomosis; this should be continued for 3 days. \ No newline at end of file diff --git a/233/InvasionFront_CD3_block13_x5_y9_patient233_0.json b/233/InvasionFront_CD3_block13_x5_y9_patient233_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b032a9f1ac1db9482a38d7c33cff628e5651e26 --- /dev/null +++ b/233/InvasionFront_CD3_block13_x5_y9_patient233_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 21588.6, + "Num Detections": 17196, + "Num Negative": 16061, + "Num Positive": 1135, + "Positive %": 6.6, + "Num Positive per mm^2": 557.11 + } +} \ No newline at end of file diff --git a/233/InvasionFront_CD3_block13_x6_y9_patient233_1.json b/233/InvasionFront_CD3_block13_x6_y9_patient233_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c5429e162e42d81de3d068b523bebd81b4cfd4b --- /dev/null +++ b/233/InvasionFront_CD3_block13_x6_y9_patient233_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 21538.6, + "Num Detections": 18116, + "Num Negative": 17744, + "Num Positive": 372, + "Positive %": 2.053, + "Num Positive per mm^2": 167.63 + } +} \ No newline at end of file diff --git a/233/InvasionFront_CD8_block13_x5_y9_patient233_0.json b/233/InvasionFront_CD8_block13_x5_y9_patient233_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0b841ac9ac77cda5d3c0e1179ce7452507c4fa86 --- /dev/null +++ b/233/InvasionFront_CD8_block13_x5_y9_patient233_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 23612.5, + "Num Detections": 17484, + "Num Negative": 16783, + "Num Positive": 701, + "Positive %": 4.009, + "Num Positive per mm^2": 341.73 + } +} \ No newline at end of file diff --git a/233/InvasionFront_CD8_block13_x6_y9_patient233_1.json b/233/InvasionFront_CD8_block13_x6_y9_patient233_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2c765777e69250e5f3a4400aef7853f02e9fe918 --- /dev/null +++ b/233/InvasionFront_CD8_block13_x6_y9_patient233_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19414.7, + "Centroid Y µm": 23762.4, + "Num Detections": 18862, + "Num Negative": 18484, + "Num Positive": 378, + "Positive %": 2.004, + "Num Positive per mm^2": 157.69 + } +} \ No newline at end of file diff --git a/233/TumorCenter_CD3_block13_x5_y9_patient233_0.json b/233/TumorCenter_CD3_block13_x5_y9_patient233_0.json new file mode 100644 index 0000000000000000000000000000000000000000..541a67bba7cf034ff068e4d0416ff3d28394cef4 --- /dev/null +++ b/233/TumorCenter_CD3_block13_x5_y9_patient233_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 29184.5, + "Num Detections": 22515, + "Num Negative": 12000, + "Num Positive": 10515, + "Positive %": 46.7, + "Num Positive per mm^2": 3926.1 + } +} \ No newline at end of file diff --git a/233/TumorCenter_CD3_block13_x6_y9_patient233_1.json b/233/TumorCenter_CD3_block13_x6_y9_patient233_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7d114e3b7e86e2c4df83e35dff7d5d210b9539f0 --- /dev/null +++ b/233/TumorCenter_CD3_block13_x6_y9_patient233_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 29384.4, + "Num Detections": 19977, + "Num Negative": 11639, + "Num Positive": 8338, + "Positive %": 41.74, + "Num Positive per mm^2": 3354.2 + } +} \ No newline at end of file diff --git a/233/TumorCenter_CD8_block13_x5_y9_patient233_0.json b/233/TumorCenter_CD8_block13_x5_y9_patient233_0.json new file mode 100644 index 0000000000000000000000000000000000000000..36c468f8bcf9c1277b689255060c3d740956ca25 --- /dev/null +++ b/233/TumorCenter_CD8_block13_x5_y9_patient233_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17690.6, + "Centroid Y µm": 21663.5, + "Num Detections": 21410, + "Num Negative": 13342, + "Num Positive": 8068, + "Positive %": 37.68, + "Num Positive per mm^2": 3104.6 + } +} \ No newline at end of file diff --git a/233/TumorCenter_CD8_block13_x6_y9_patient233_1.json b/233/TumorCenter_CD8_block13_x6_y9_patient233_1.json new file mode 100644 index 0000000000000000000000000000000000000000..38eca7ed341715b9ce8f5483c22e0c44df854754 --- /dev/null +++ b/233/TumorCenter_CD8_block13_x6_y9_patient233_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20289.3, + "Centroid Y µm": 21288.7, + "Num Detections": 18236, + "Num Negative": 11695, + "Num Positive": 6541, + "Positive %": 35.87, + "Num Positive per mm^2": 2762.5 + } +} \ No newline at end of file diff --git a/233/history_text.txt b/233/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d6e8a1a8392cb63ecda626d61a7da7f2505822c --- /dev/null +++ b/233/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: mass in the area of the posterior third of the tongue. \ No newline at end of file diff --git a/233/icd_codes.txt b/233/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2405a3a2a1f520660c5cade89c8e5753d0d51ba7 --- /dev/null +++ b/233/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] \ No newline at end of file diff --git a/233/ops_codes.txt b/233/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b4e689edc4b51bb0b2ff4e734ded953dbf7aeb60 --- /dev/null +++ b/233/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Bronchoskopie und Tracheoskopie durch Inzision und intraoperativ: Tracheoskopie[1-690.1 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Inzision am Zungenrand[5-250.0 ] \ No newline at end of file diff --git a/233/patient_clinical_data.json b/233/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..69d599de1948055ce89a762821e8100f4f9887c5 --- /dev/null +++ b/233/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/233/patient_pathological_data.json b/233/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3412c93287ae8917a1a1f39c507a82ba2f9c8026 --- /dev/null +++ b/233/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "233", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/233/surgery_description.txt b/233/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..25a0d609b562b6f8a4c338a8f4986a5c5003b1fa --- /dev/null +++ b/233/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy of the tongue margin, Panendoscopy diff --git a/233/surgery_report.txt b/233/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d6484ab4efaa1f51223fc2b38b37f128f2e2f4d --- /dev/null +++ b/233/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. First advance the 0° optic through the glottic plane into the trachea. Advance to the exit of the segmental bronchi. Inconspicuous mucosal conditions on both sides up to the exit of the segmental bronchi. No abnormalities in the area of the cervical trachea either. Now intubation of the patient. Inspection of the subglottis, glottis and supraglottis. Unobtrusive mucosal conditions. Inspection of the hypopharynx on both sides and the postcricoid region. No special features here either. Inspection of the oropharynx and after pulling up the soft palate of the nasopharynx. Inconspicuous mucosal conditions on all sides. Advancement of the flexible esophagoscope into the stomach. Inconspicuous mucosal conditions in the area of the stomach and the esophagus. Adjustment of the mouth with the ratchet. Pulling out the tongue. A mass of approx. 0.5 - 0.7 cm, which appears papillomatous, can be seen in the area of the right edge of the tongue, on the posterior third of the tongue. Cut around this mass with the electric needle at a sufficient safety distance. Careful dissection of this tumor. Mark the specimen. Careful hemostasis. Inverting sutures to close the wound. Inspection of the rest of the oral cavity. Inconspicuous mucosal conditions here. Completion of the procedure. Final consultation with the anesthetist. \ No newline at end of file diff --git a/234/InvasionFront_CD3_block6_x3_y6_patient234_0.json b/234/InvasionFront_CD3_block6_x3_y6_patient234_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d86ec10aee13cd88e7a6f091ef63d0366c8fb425 --- /dev/null +++ b/234/InvasionFront_CD3_block6_x3_y6_patient234_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12068.6, + "Centroid Y µm": 15641.7, + "Num Detections": 23449, + "Num Negative": 22892, + "Num Positive": 557, + "Positive %": 2.375, + "Num Positive per mm^2": 223.48 + } +} \ No newline at end of file diff --git a/234/InvasionFront_CD3_block6_x4_y6_patient234_1.json b/234/InvasionFront_CD3_block6_x4_y6_patient234_1.json new file mode 100644 index 0000000000000000000000000000000000000000..58990131943bed789eace24abda2386c59d11149 --- /dev/null +++ b/234/InvasionFront_CD3_block6_x4_y6_patient234_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14792.2, + "Centroid Y µm": 15841.6, + "Num Detections": 25718, + "Num Negative": 22954, + "Num Positive": 2764, + "Positive %": 10.75, + "Num Positive per mm^2": 1043.2 + } +} \ No newline at end of file diff --git a/234/InvasionFront_CD8_block6_x3_y4_patient234_0.json b/234/InvasionFront_CD8_block6_x3_y4_patient234_0.json new file mode 100644 index 0000000000000000000000000000000000000000..38b78670b761dead416eb6d2ac4a88af978b779f --- /dev/null +++ b/234/InvasionFront_CD8_block6_x3_y4_patient234_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12693.3, + "Centroid Y µm": 9769.8, + "Num Detections": 18222, + "Num Negative": 17268, + "Num Positive": 954, + "Positive %": 5.235, + "Num Positive per mm^2": 488.02 + } +} \ No newline at end of file diff --git a/234/InvasionFront_CD8_block6_x4_y4_patient234_1.json b/234/InvasionFront_CD8_block6_x4_y4_patient234_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3903b92ef6dedcb895b1137687e7f48f3b5a0848 --- /dev/null +++ b/234/InvasionFront_CD8_block6_x4_y4_patient234_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15092.0, + "Centroid Y µm": 9994.7, + "Num Detections": 18824, + "Num Negative": 18386, + "Num Positive": 438, + "Positive %": 2.327, + "Num Positive per mm^2": 220.4 + } +} \ No newline at end of file diff --git a/234/TumorCenter_CD3_block6_x3_y4_patient234_0.json b/234/TumorCenter_CD3_block6_x3_y4_patient234_0.json new file mode 100644 index 0000000000000000000000000000000000000000..30d5de3d5b7e23d6b669d0b31c9ad079212e3707 --- /dev/null +++ b/234/TumorCenter_CD3_block6_x3_y4_patient234_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11244.0, + "Centroid Y µm": 10119.6, + "Num Detections": 17914, + "Num Negative": 15782, + "Num Positive": 2132, + "Positive %": 11.9, + "Num Positive per mm^2": 1079.0 + } +} \ No newline at end of file diff --git a/234/TumorCenter_CD3_block6_x4_y4_patient234_1.json b/234/TumorCenter_CD3_block6_x4_y4_patient234_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b31a6e8fa7f728f0a9660b0e023d66b79ab3e0c6 --- /dev/null +++ b/234/TumorCenter_CD3_block6_x4_y4_patient234_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 10119.6, + "Num Detections": 19435, + "Num Negative": 17322, + "Num Positive": 2113, + "Positive %": 10.87, + "Num Positive per mm^2": 1054.7 + } +} \ No newline at end of file diff --git a/234/TumorCenter_CD8_block6_x3_y4_patient234_0.json b/234/TumorCenter_CD8_block6_x3_y4_patient234_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e648ab86a713cf65bb43de100674da5177fb1c95 --- /dev/null +++ b/234/TumorCenter_CD8_block6_x3_y4_patient234_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11294.0, + "Centroid Y µm": 10569.4, + "Num Detections": 19792, + "Num Negative": 17759, + "Num Positive": 2033, + "Positive %": 10.27, + "Num Positive per mm^2": 1027.0 + } +} \ No newline at end of file diff --git a/234/TumorCenter_CD8_block6_x4_y4_patient234_1.json b/234/TumorCenter_CD8_block6_x4_y4_patient234_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1163ad798299efd9d9227957238fb0dad82d819a --- /dev/null +++ b/234/TumorCenter_CD8_block6_x4_y4_patient234_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 10569.4, + "Num Detections": 20706, + "Num Negative": 19112, + "Num Positive": 1594, + "Positive %": 7.698, + "Num Positive per mm^2": 795.5 + } +} \ No newline at end of file diff --git a/234/history_text.txt b/234/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..af94ad61c65acb13db8ebf5fca67df517d4b6c76 --- /dev/null +++ b/234/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the left. This is located at the arytenoid fold medially, reaching the arytenoid cartilage and in the piriform sinus anteriorly and at the lateral border. The above-mentioned surgery is therefore indicated and flap coverage is also planned if necessary. \ No newline at end of file diff --git a/234/icd_codes.txt b/234/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..739d9698e26651477346fcfa3195fb70564f6265 --- /dev/null +++ b/234/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] \ No newline at end of file diff --git a/234/ops_codes.txt b/234/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ed9efff92bcb4ff165b3703a3d142ad8f93f9f8 --- /dev/null +++ b/234/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/234/patient_clinical_data.json b/234/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8070caf0b36d8a0e4b81646a63f8b64a8a4e46cd --- /dev/null +++ b/234/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 74, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/234/patient_pathological_data.json b/234/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9f64e8984731d1f12af2acf018afa378e80cac0f --- /dev/null +++ b/234/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "234", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/234/surgery_description.txt b/234/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5d146b5a9b4d38f2cc2aa011903ca87794bfe242 --- /dev/null +++ b/234/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Partial pharyngectomy, Radical left neck dissection, PEG placement, Provox Prosthesis, Endoscopy diff --git a/234/surgery_report.txt b/234/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e7ac0c870ea5674dcd609b3f2f51fc97c3a5b395 --- /dev/null +++ b/234/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again, tumour localization and extent confirmed. PEG insertion: Careful insertion of the flexible instrument into the stomach. Identification of the anterior wall of the stomach and observation of a positive diaphanoscopy. Abdominal wall puncture and PEG insertion in the usual manner using the suture pull-through method without complications. Subsequent repositioning for neck dissection on both sides and laryngectomy with partial pharyngectomy on the left. Apposition of the apron flap in the typical manner. Neck dissection on the right side and release of the larynx, tracheotomy and performance of the myotomy: repositioning of the patient for laryngectomy in the head reclination position. Injection of Suprarenin in the area of the skin incision (apron flap). Sterile wiping and draping of the patient. Start the operation by making a skin incision on both sides of the anterior edge of the sternocleidomastoid muscle to below the cricoid (apron flap). Separation of the cutaneous and subcutaneous tissue and subplatysmal flap elevation. After exposing the hyoid bone and the submandibular glandulae on both sides, the apron flap is sutured cranially. Transition to neck dissection on the right side by exposing the anterior border of the sternocleidomastoid muscle and sharp dissection down to the depths until the deep plexus branches become visible. Identification of the accessorius nerve and removal of the nerve from the neck preparation. Exposure of the posterior venter of the digastric muscle at the cranial end of the neck and dissection along the muscle to the hyoid bone. Now identification of the omohyoid muscle and dissection along the muscle also up to the hyoid bone. Insertion of the caudal retractor and exposure of the cervical vascular nerve sheath. The neck preparation is dissected free to the cervical vascular nerve sheath and removed from cranial to caudal in the usual manner while protecting the vascular and nerve structures. No suspicious nodules are detected during dissection. Identification of the carotid bifurcation and visualization of the superior thyroid artery. Separation of the superior thyroid artery close to the larynx. Separation of the infrahyoid muscles at the hyoid bone and dissection of the muscles caudally. Skeletonize the larynx in the usual manner. At the caudal end, remove and free the thyroid gland from the cricoid cartilage and the trachea. Now expose the thyroid isthmus, undermine the isthmus and cut the isthmus after bipolar coagulation. Entry into the trachea after saturation of the patient in the 2nd to 3rd intratracheal space. Re-intubation and suturing of the tracheostoma in the caudal region. Radical neck dissection on the left: A large lymph node or lymph node conglomerate is visible cranially, which extends to the large vessels. Successive dissection of the node away from the adjacent, neighboring structures. This is initially carried out cranially, taking the digastric muscle and the hypoglossal nerve with it, which run directly into the lymph node conglomerate. The accessor nerve and the cranial insertion of the sternocleidomastoid muscle are also resected cranially. Exposure of the vessels from the medial side. The facial vein is ligated. The internal jugular vein is also removed caudally and ligated twice caudally. Further dissection of the conglomerate cranially along the common carotid artery, later internally and externally. The bifurcation is dissected, here the tumor reaches directly, but it is possible to dissect a layer of adventitia and thus completely dissect the tumor from the internal carotid artery and out of the bifurcation. Further cranial infiltration of the externa. This is therefore removed shortly after the bifurcation and treated here using 4-0 prolene sutures. The external carotid artery is also removed cranially. The internal jugular vein is also removed, which is ligated twice cranially. The vagus nerve can also be dissected straight from the tumor, there is no direct tumor infiltration here, it can be dissected bluntly. Several branches of the cervical plexus must also be resected. The sternocleidomastoid muscle must also be removed caudally. The accessorius nerve is also removed. After removal of the main lymph node conglomerate, further neck dissection, ultimately level II to V. This involves partial preservation of the branches of the cervical plexus. Phrenic nerve preserved. Also border cord. Subsequent irrigation of the wound area and hemostasis. Laryngectomy follows: dissection of the suprahyoid muscles from the hyoid bone. Also dissection of the infrahyoid muscles from the hyoid bone, which is cut caudally. Skeletonization of the larynx on the right side, exposing the superior cornu. Detachment of the constrictor pharyngis muscle. Dissection of the thyroid glands latero-caudally on both sides. Separation of the isthmus here. Subsequent creation of a tracheotomy and insertion of a laryngectomy tube after reintubation. Then cranial exposure of the epiglottis from the outside. The epiglottis is isolated with maximum preservation of the mucosa. You now have a good view of the tumor. The tumor is resected with a safety margin of at least 1.5 cm on all sides on the left side of the pharynx. Maximum preservation of the mucosa on the right side. Subsequent release of the larynx in the area of the pharyngoesophageal junction. Then separation of the larynx from the trachea in a typical manner. Marking of the tumor specimen using sutures. To be on the safe side, a marginal sample is taken from the hypopharynx on the left from the area of the transition to the postcricoid up to the transition to the base of the tongue and is also marked with sutures for the frozen section. Overall, all specimens together indicate an R0 situation. The left myotomy now follows. The constrictor pharyngis muscle on the left side is successively severed up to the mucosa to facilitate passage through the pharyngoesophageal junction. Provox prosthesis insertion is then carried out by inserting an 8 mm prosthesis, which is inserted without complications and in a typical manner. Subsequent closure of the pharynx, which is easily possible in the first instance, by means of an inverting layer using 4-0 Vicryl single button sutures. A further layer of inverting sutures, also with 4-0 Vicryl single button sutures, is placed on top. A third layer can be applied cranially, but this must be omitted in the area of the pharyngeal tube due to the hypopharyngeal resection, which also involved the muscular wall. Caudally, the musculature of the omohyoid muscle is still sutured via the pharyngoesophageal junction, as is the thyroid gland. The wound area is then irrigated again and the bleeding stopped. Wound closure in layers with insertion of a Redon drain on both sides and epithelialization of the tracheostoma. Insertion of a 9 mm tracheostomy tube at the end. Completion of the procedure without complications. Patient transferred to the intensive care unit for monitoring. Overall cT2-3 hypopharyngeal carcinoma on the left. No larynx-preserving therapy indicated due to the overall situation and the expected dysphagia in the patient's condition, in particular the presence of COPD. Postoperative nutrition via the inserted gastric tube or PEG tube. This for 7 to 10 days, then gruel and, if necessary, dietary support. Due to the large mass on the left, postoperative RCT is certainly indicated adjuvantly. Tumor could be easily removed from the common carotid artery or bifurcation and interna after pushing off with the adventitia. Nonetheless, the lymph node conglomerate was also present on the internal carotid artery for a long time. Presentation at the interdisciplinary tumor conference after receipt of the final histology. \ No newline at end of file diff --git a/235/InvasionFront_CD8_block5_x3_y11_patient235_0.json b/235/InvasionFront_CD8_block5_x3_y11_patient235_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f6d9dc5209bb43e56f196d87f267b77b4b830050 --- /dev/null +++ b/235/InvasionFront_CD8_block5_x3_y11_patient235_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 27385.5, + "Num Detections": 10753, + "Num Negative": 5381, + "Num Positive": 5372, + "Positive %": 49.96, + "Num Positive per mm^2": 3511.3 + } +} \ No newline at end of file diff --git a/235/InvasionFront_CD8_block5_x4_y11_patient235_1.json b/235/InvasionFront_CD8_block5_x4_y11_patient235_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bbf8459fbff1d79d223f7d7626139a2339b00e92 --- /dev/null +++ b/235/InvasionFront_CD8_block5_x4_y11_patient235_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 27535.4, + "Num Detections": 8479, + "Num Negative": 4453, + "Num Positive": 4026, + "Positive %": 47.48, + "Num Positive per mm^2": 3106.3 + } +} \ No newline at end of file diff --git a/235/TumorCenter_CD3_block5_x3_y11_patient235_0.json b/235/TumorCenter_CD3_block5_x3_y11_patient235_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eaae119354833879dfc1431fc2cba7b653d44eb0 --- /dev/null +++ b/235/TumorCenter_CD3_block5_x3_y11_patient235_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 27260.6, + "Num Detections": 18716, + "Num Negative": 13638, + "Num Positive": 5078, + "Positive %": 27.13, + "Num Positive per mm^2": 2279.7 + } +} \ No newline at end of file diff --git a/235/TumorCenter_CD3_block5_x4_y11_patient235_1.json b/235/TumorCenter_CD3_block5_x4_y11_patient235_1.json new file mode 100644 index 0000000000000000000000000000000000000000..694e25ccd8a02274cd6f2f54f4b8fe5172589351 --- /dev/null +++ b/235/TumorCenter_CD3_block5_x4_y11_patient235_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13193.0, + "Centroid Y µm": 27485.4, + "Num Detections": 16654, + "Num Negative": 14041, + "Num Positive": 2613, + "Positive %": 15.69, + "Num Positive per mm^2": 1215.0 + } +} \ No newline at end of file diff --git a/235/TumorCenter_CD8_block5_x3_y11_patient235_0.json b/235/TumorCenter_CD8_block5_x3_y11_patient235_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f365906f340d2185e3d91fabb8a614388696602a --- /dev/null +++ b/235/TumorCenter_CD8_block5_x3_y11_patient235_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 27610.4, + "Num Detections": 18235, + "Num Negative": 13136, + "Num Positive": 5099, + "Positive %": 27.96, + "Num Positive per mm^2": 2258.9 + } +} \ No newline at end of file diff --git a/235/TumorCenter_CD8_block5_x4_y11_patient235_1.json b/235/TumorCenter_CD8_block5_x4_y11_patient235_1.json new file mode 100644 index 0000000000000000000000000000000000000000..61bc362d1e16dd06faef7dd5090aad9afb471626 --- /dev/null +++ b/235/TumorCenter_CD8_block5_x4_y11_patient235_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 27635.4, + "Num Detections": 16463, + "Num Negative": 13896, + "Num Positive": 2567, + "Positive %": 15.59, + "Num Positive per mm^2": 1174.2 + } +} \ No newline at end of file diff --git a/235/history_text.txt b/235/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/235/icd_codes.txt b/235/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adab28f0b88ba31c5bb4895a3d4f3034f2967b3e --- /dev/null +++ b/235/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] \ No newline at end of file diff --git a/235/ops_codes.txt b/235/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..882de96cf95b3d496f04f31873b7b580158f4024 --- /dev/null +++ b/235/ops_codes.txt @@ -0,0 +1 @@ +mikrovaskulär-anastomosierten Transplantat[5-296.24 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Sonstige diagnostische Ösophagoskopie[1-630.x ] Temporäre Tracheotomie[5-311.0 ] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] Spalthaut bei Verbrennungen und Verätzungen Empfängerstelle Unterarm[5-925.08 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] \ No newline at end of file diff --git a/235/patient_clinical_data.json b/235/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..00bd3ae8311f168e21e29d71409c9680ee965613 --- /dev/null +++ b/235/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/235/patient_pathological_data.json b/235/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1c707e9943ef41154f49101d3d291fc5254b2513 --- /dev/null +++ b/235/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "235", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 50, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/235/surgery_description.txt b/235/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..27e0f5301df81ddeecf60a8e8e2807b375485b7e --- /dev/null +++ b/235/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Selective bilateral neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/235/surgery_report.txt b/235/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..dbcdf8ba2c2b76e9914df30fdfb2632df5c703aa --- /dev/null +++ b/235/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first attempt to insert a PEG. This is not successful in the absence of diaphanoscopy, so a nasogastric feeding tube is inserted via the left nostril. Then insertion of the T-barrier and start of transoral tumor resection with the ultrasonic knife. The soft palate is resected almost completely on the right side. The resection then extends caudally on the posterior wall of the hypopharynx approximately in the median line. Laterally, pterygoid muscles and the fatty tissue of the soft tissues of the neck are reached. The tumor can thus be dissected out successively with an appropriate safety margin up to the glossotonsillar groove and at the base of the tongue and finally removed. Inspection of the specimen after removal. A muscular cuff is still present at the base of the tumor, but slightly less than at the edges. Therefore, a resection is performed from the muscles at the corresponding site. Samples are then taken from the margins around the defect. All histologies are examined using frozen section histology and are found to be tumor-free, including the main specimen. Subsequently, transition to neck dissection on the right side. The anterior edge of the sternocleidomastoid muscle is skeletonized after a skin incision. Then skeletonize the digastric muscle and successively remove regions II to V while preserving all non-lymphatic structures. There is no indication of a suspicious lymph node. Subsequent evacuation of regions Ia and Ib including submandibulectomy. The defect is completed in the pharyngeal direction. The lingual nerve and the hypoglossal nerve are exposed and can be spared. Dissection of the superior thyroid vein for the subsequent anastomosis. Subsequent transition to the opposite side. Here, regions II to V are dissected in the usual way, preserving all non-lymphatic structures. Here too, there is no clinical evidence of a suspicious lymph node. Insertion of a Redon suction drain on the left side and two-layer wound closure in the usual manner. In the meantime, start lifting the radial lobe graft from the left forearm. The defect measures approximately 11 x 7.5 cm. After an S-shaped skin incision, the superficial vein is dissected distally. The two muscle bellies are then pushed apart with identification of the underlying vascular pedicle. This is dissected circularly. The flap is then first incised ulnarly down to the fascia and dissected radially down to the tendon of the flexor carpi muscle. Similarly, the flap is dissected radially while sparing the sensitive nerve. The pedicle and the entire flap are then detached from its base. The confluence is then dissected cranially, exposing the exit of the radial artery and dissecting two superficial veins beyond the antecubital fossa. The radial artery flap graft was then removed. In the meantime, the split-thickness skin was removed from the right thigh. This is then used to cover the defect on the left forearm. Now insertion of the radialis graft into the oropharyngeal defect. The graft is sutured into the defect transorally, whereby the cranial part is doubled in the area of the soft palate. The graft is then sutured caudally close to the base of the tongue. However, the last 5 sutures are performed transcervically from the right. The arterial anastomosis of the radial artery to the superior thyroid artery is then performed. The two veins of the left arm are then connected to the internal jugular vein using an end-to-side technique. Then carefully stop some bleeding from the flap until the blood is dry. Previously a Redon suction drainage into the right side of the neck. Insertion of an Easy flow drainage. Checking the patency of the venous anastomoses. Two-layer wound closure. In addition, the tracheostomy was performed between the 2nd and 3rd tracheal clasp by and completion of the mucocutaneous anastomosis. Finally, after completion of the operation, sterile neck dressing and reintubation of the patient on a 9-gauge tracheostomy tube. Conclusion: Transoral resection of a tonsillar carcinoma on the right side and selective neck dissection on both sides with preservation of all non-lymphatic structures. Right oropharyngeal defect coverage with a radial flap graft from the left forearm. Defect coverage on the left forearm with split skin from the right thigh. Additional tracheotomy performed. Unsuccessful attempt to insert a PEG in the absence of a diaphanoscopy. \ No newline at end of file diff --git a/236/InvasionFront_CD8_block5_x3_y12_patient236_0.json b/236/InvasionFront_CD8_block5_x3_y12_patient236_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1da8bea6c89fbc0df6289ec371418ee26c0271e2 --- /dev/null +++ b/236/InvasionFront_CD8_block5_x3_y12_patient236_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11269.0, + "Centroid Y µm": 29909.2, + "Num Detections": 20188, + "Num Negative": 19178, + "Num Positive": 1010, + "Positive %": 5.003, + "Num Positive per mm^2": 441.58 + } +} \ No newline at end of file diff --git a/236/InvasionFront_CD8_block5_x4_y12_patient236_1.json b/236/InvasionFront_CD8_block5_x4_y12_patient236_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1bd3cbb87e3adb4404a9b1823e384aa45172acc1 --- /dev/null +++ b/236/InvasionFront_CD8_block5_x4_y12_patient236_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 29934.2, + "Num Detections": 18408, + "Num Negative": 17639, + "Num Positive": 769, + "Positive %": 4.178, + "Num Positive per mm^2": 341.51 + } +} \ No newline at end of file diff --git a/236/TumorCenter_CD3_block5_x3_y12_patient236_0.json b/236/TumorCenter_CD3_block5_x3_y12_patient236_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eabc0f9f03815b6df91180707fea624934ec9012 --- /dev/null +++ b/236/TumorCenter_CD3_block5_x3_y12_patient236_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10719.3, + "Centroid Y µm": 29834.2, + "Num Detections": 11199, + "Num Negative": 8455, + "Num Positive": 2744, + "Positive %": 24.5, + "Num Positive per mm^2": 1990.7 + } +} \ No newline at end of file diff --git a/236/TumorCenter_CD3_block5_x4_y12_patient236_1.json b/236/TumorCenter_CD3_block5_x4_y12_patient236_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d02cf49a9486ccd8408579a0fbaaf5ff0d90323 --- /dev/null +++ b/236/TumorCenter_CD3_block5_x4_y12_patient236_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12993.1, + "Centroid Y µm": 29884.2, + "Num Detections": 15235, + "Num Negative": 11735, + "Num Positive": 3500, + "Positive %": 22.97, + "Num Positive per mm^2": 1775.2 + } +} \ No newline at end of file diff --git a/236/TumorCenter_CD8_block5_x3_y12_patient236_0.json b/236/TumorCenter_CD8_block5_x3_y12_patient236_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1a172d53e43d605559df4130155d290c46763e21 --- /dev/null +++ b/236/TumorCenter_CD8_block5_x3_y12_patient236_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10969.2, + "Centroid Y µm": 30209.0, + "Num Detections": 10269, + "Num Negative": 9236, + "Num Positive": 1033, + "Positive %": 10.06, + "Num Positive per mm^2": 910.98 + } +} \ No newline at end of file diff --git a/236/TumorCenter_CD8_block5_x4_y12_patient236_1.json b/236/TumorCenter_CD8_block5_x4_y12_patient236_1.json new file mode 100644 index 0000000000000000000000000000000000000000..10f00525a7c16cc36cbcba67e820c5f25ae477e1 --- /dev/null +++ b/236/TumorCenter_CD8_block5_x4_y12_patient236_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 30159.0, + "Num Detections": 13206, + "Num Negative": 11927, + "Num Positive": 1279, + "Positive %": 9.685, + "Num Positive per mm^2": 707.44 + } +} \ No newline at end of file diff --git a/236/history_text.txt b/236/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/236/icd_codes.txt b/236/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e16ef091ee500716c4e1e1b9bd1c8bb2ae2d348d --- /dev/null +++ b/236/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/236/ops_codes.txt b/236/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c10277a30ff1525d081fd4eddddb24547c2aace5 --- /dev/null +++ b/236/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Transplantat[5-295.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Temporäre Tracheotomie[5-311.0 ] Sonstige perkutan-endoskopisch Gastrostomie (PEG)[5-431.2x ] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Großflächige freie Spalthauttransplantation auf granulierendes Hautareal am Unterarm[5-902.58 L] Spalthaut bei Verbrennungen und Verätzungen Entnahmestelle Oberschenkel und Knie[5-924.0e R] \ No newline at end of file diff --git a/236/patient_clinical_data.json b/236/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..08b2e21c1f62322e5eab8b1f2a0d153c3b345800 --- /dev/null +++ b/236/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/236/patient_pathological_data.json b/236/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bb0256e7dd93c1d02cdc3fa8bbeee04fe2e79237 --- /dev/null +++ b/236/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "236", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 56, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/236/surgery_description.txt b/236/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b779a3a5dcaf6d10491a3474eba3a3bd1825487 --- /dev/null +++ b/236/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Modified radical bilateral neck dissection, Tracheotomy, Defect coverage, Free flap (Radial), PEG placement diff --git a/236/surgery_report.txt b/236/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ae1b4e00109b2deed591238e22f325597456f64 --- /dev/null +++ b/236/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation transnasally by the anesthesia colleagues. Insertion of the McIvor oral spatula and inspection of the tumor. The tumor is in the area of the glossotonsillar groove, extends to the anterior palatal arch and to the alveolar ridge of the mandible on the right. Start with tumor resection in the area of the anterior palatal arch parauvularly. Continue in the area of the alveolar ridge, then in the area of the tonsillar loge and in the base of the tongue. The tumor is removed en bloc with a safety margin of 1 cm on all sides. The tumor is then thread-marked and needle-marked and placed on cork for a frozen section. All margins free of tumor and carcinoma in situ. Measurement of the defect, 6 x 8 cm. Radialis flap left, elevation of the graft () Sterile ablation and covering of the left arm. Marking of the flap and landmarks. Checking the pulse oximeter. Skin incision and dissection through the subcutaneous fatty tissue. Exposure of the cephalic vein and dissection on the cephalic vein and laterally from this onto the muscle. Exposure of the venous confluence in depth. Dissection of the flexor carpi radialis muscle and the muscle belly. Dissect the cephalic vein and enter between the two muscle bellies. Now closely dissect the muscle bellies in depth and locate the vascular pedicle. This pulsates well. Careful dissection of both the brachioradialis muscle and the flexor carpi radialis muscle. Now cut around the ulnar side of the flap, dissect through the fascia and lift the musculofascial flap up to the tendon of the flexor carpi radialis muscle. Suture the fascia to the graft to avoid shearing. Now further dissection of the lateral cephalic vein caudally and inclusion of the cephalic vein in the graft. Here 2 lateral branches are cut off. Dissection of the musculocircular flap also from the radial side while sparing the sensory branch of the radial nerve. Identification of the radial artery caudally. Further preparation of the vascular pedicle and dissection of the vascular pedicle from the surrounding tissue with bipolar coagulation and multiple clips for the perforator vessels. Now lift off the complete flap graft in the case of vessels left in situ in the sense of the radial artery and the cephalic vein. Dissection of the superficial and deep veins as well as the branch of the radial artery from the brachial artery. Separation of the radial flap and ligation of the venous vessels with zero ligatures and the arterial vessels with silk. Careful hemostasis is performed. The split skin is then lifted from the right thigh and the split skin is sutured in the usual manner and the arm is closed in two layers. The pie crust was applied and a pressure bandage and plaster cast were applied to immobilize the arm. Saturation was stable at over 93% throughout the operation and remained stable even after removal of the radial artery, Allen test negative. Neck dissection performed by : Neck dissection first performed on the left side, region Ib to V. S-shaped skin incision on the anterior border of the sternocleidomastoid muscle approx. 2 QF below the mandible. Separation of the cutaneous/subcutaneous tissue. Separation of the platysma. Subplatysmal dissection of the skin flap ventrally and dorsally. Identification of the anterior border of the sternocleidomastoid muscle and dissection in depth to expose the plexus branches of the cervical plexus. Now identification of the omohyoid muscle. Dissection of the omohyoid muscle from lateral inferior to medial superior up to the hyoid bone. Insertion of the inferior round ratchet. Identification of the submandibular gland and elevation of the gland to locate the digastric muscle. After free preparation of the venter posterior digastric muscle and insertion of the wide retractor under the muscle (Langenbeck). Now identify the accessorius nerve and free dissection from the neck tissue. Now sharp dissection along the internal jugular vein from caudal to cranial and lateral displacement of the neck dissection. Sharp dissection along the vein and freeing of the neck preparation from the cervical vascular nerve sheath. Separation of the neck dissection from the deep cervical fascia from cranial to caudal while preserving all nerve and vascular structures. Now elevation of the entire submandibular gland and removal of the lymphatic tissue in the area of region Ib. Two-layer wound closure after insertion of a Redon drainage and completion of the neck dissection on the left side without complications. Now turn to the right side. First perform the neck dissection on the right side region Ib to V. S-shaped skin incision on the anterior border of the sternocleidomastoid muscle approx. 2 QF below the mandible. Separation of the cutaneous/subcutaneous tissue. Separation of the platysma. Subplatysmal dissection of the skin flap ventrally and dorsally. Identification of the anterior border of the sternocleidomastoid muscle and dissection in depth to expose the plexus branches of the cervical plexus. Now identification of the omohyoid muscle. Dissection of the omohyoid muscle from lateral inferior to medial superior up to the hyoid bone. Insertion of the inferior round ratchet. Identification of the submandibular gland and elevation of the gland to locate the digastric muscle. After free preparation of the venter posterior digastric muscle and insertion of the wide retractor under the muscle (Langenbeck). Now identify the accessorius nerve and free dissection from the neck tissue. Now sharp dissection along the internal jugular vein from caudal to cranial and lateral displacement of the neck dissection. Sharp dissection along the vein and freeing of the neck preparation from the cervical vascular nerve sheath. Separation of the neck dissection now also from the deep cervical fascia from cranial to caudal while preserving all nerve and vascular structures. Dissection close to the gland and release of the submandibular gland from its glandular bed. Ligation of the Wharton's duct. Separation of the submandibular gland. Now also sharply cut through the digastricus venter posterior muscle and the stylohyoid muscle. This creates an opening in the oropharynx that is over 3 fingers wide. The connecting vessels are then exposed. The lingual artery and the superior thyroid artery are freed from the surrounding tissue. For the vascular anastomosis, the superior thyroid artery is selected and exposed. The flap graft is inserted pharyngeally. First adaptation of the cranial flap edge with the pharyngeal mucosa from the enoral side. Finally, several sutures are placed and the graft is sutured from the cervical side in the area of the caudal edge of the graft. Perform the vascular anastomosis using the superior thyroid artery and end-to-end anastomosis using single button sutures to the flap artery. Perform venous anastomosis using two end-to-side anastomoses to the internal jugular vein using a single-button technique. With good diaphanoscopy, problem-free PEG insertion using the thread pull-through method. At the end, insertion of an easy-flow drainage and two-layer wound closure after subtle hemostasis using bipolar coagulation forceps and multiple wound irrigation. \ No newline at end of file diff --git a/237/InvasionFront_CD3_block7_x5_y9_patient237_0.json b/237/InvasionFront_CD3_block7_x5_y9_patient237_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d601ae0016e1e92e91ef541d5876bff8512c0b51 --- /dev/null +++ b/237/InvasionFront_CD3_block7_x5_y9_patient237_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16491.3, + "Centroid Y µm": 21888.4, + "Num Detections": 18967, + "Num Negative": 18737, + "Num Positive": 230, + "Positive %": 1.213, + "Num Positive per mm^2": 104.57 + } +} \ No newline at end of file diff --git a/237/InvasionFront_CD3_block7_x6_y9_patient237_1.json b/237/InvasionFront_CD3_block7_x6_y9_patient237_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2e816b3381e53143771c0254538a6694cf2ae47 --- /dev/null +++ b/237/InvasionFront_CD3_block7_x6_y9_patient237_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 21888.4, + "Num Detections": 22324, + "Num Negative": 21959, + "Num Positive": 365, + "Positive %": 1.635, + "Num Positive per mm^2": 164.29 + } +} \ No newline at end of file diff --git a/237/InvasionFront_CD8_block7_x5_y9_patient237_0.json b/237/InvasionFront_CD8_block7_x5_y9_patient237_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a366a9dfe26ad3fed7d6a541e0609fa88dade65c --- /dev/null +++ b/237/InvasionFront_CD8_block7_x5_y9_patient237_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 23412.6, + "Num Detections": 17251, + "Num Negative": 16903, + "Num Positive": 348, + "Positive %": 2.017, + "Num Positive per mm^2": 159.59 + } +} \ No newline at end of file diff --git a/237/InvasionFront_CD8_block7_x6_y9_patient237_1.json b/237/InvasionFront_CD8_block7_x6_y9_patient237_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ae1b375c779652ca66bc4fbde9040d35014ef614 --- /dev/null +++ b/237/InvasionFront_CD8_block7_x6_y9_patient237_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 23787.4, + "Num Detections": 18114, + "Num Negative": 17816, + "Num Positive": 298, + "Positive %": 1.645, + "Num Positive per mm^2": 130.0 + } +} \ No newline at end of file diff --git a/237/TumorCenter_CD3_block7_x5_y9_patient237_0.json b/237/TumorCenter_CD3_block7_x5_y9_patient237_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e5a8a517aa54c90ff9e88b8a6e2a34cc4beab30c --- /dev/null +++ b/237/TumorCenter_CD3_block7_x5_y9_patient237_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 22787.9, + "Num Detections": 22139, + "Num Negative": 21763, + "Num Positive": 376, + "Positive %": 1.698, + "Num Positive per mm^2": 155.78 + } +} \ No newline at end of file diff --git a/237/TumorCenter_CD3_block7_x6_y9_patient237_1.json b/237/TumorCenter_CD3_block7_x6_y9_patient237_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4457ddf7af47c983400aea62008664c25bb01f63 --- /dev/null +++ b/237/TumorCenter_CD3_block7_x6_y9_patient237_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 22812.9, + "Num Detections": 20060, + "Num Negative": 19648, + "Num Positive": 412, + "Positive %": 2.054, + "Num Positive per mm^2": 179.56 + } +} \ No newline at end of file diff --git a/237/TumorCenter_CD8_block7_x5_y9_patient237_0.json b/237/TumorCenter_CD8_block7_x5_y9_patient237_0.json new file mode 100644 index 0000000000000000000000000000000000000000..50b6b5587858d9bc72882d954fba40a3c2fa4f16 --- /dev/null +++ b/237/TumorCenter_CD8_block7_x5_y9_patient237_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15666.7, + "Centroid Y µm": 22538.1, + "Num Detections": 23386, + "Num Negative": 23203, + "Num Positive": 183, + "Positive %": 0.7825, + "Num Positive per mm^2": 75.09 + } +} \ No newline at end of file diff --git a/237/TumorCenter_CD8_block7_x6_y9_patient237_1.json b/237/TumorCenter_CD8_block7_x6_y9_patient237_1.json new file mode 100644 index 0000000000000000000000000000000000000000..781e997319446962d52a5a78f681379fca6c742f --- /dev/null +++ b/237/TumorCenter_CD8_block7_x6_y9_patient237_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 22538.1, + "Num Detections": 22372, + "Num Negative": 22239, + "Num Positive": 133, + "Positive %": 0.5945, + "Num Positive per mm^2": 57.46 + } +} \ No newline at end of file diff --git a/237/history_text.txt b/237/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/237/icd_codes.txt b/237/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/237/ops_codes.txt b/237/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/237/patient_clinical_data.json b/237/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0baf8d9dde5e17393d2ca22d20527b5469f8f7ec --- /dev/null +++ b/237/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "cisplatin + Docetaxel", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/237/patient_pathological_data.json b/237/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c7c2cd7cdee587abd8a3faf2abc34585875d721f --- /dev/null +++ b/237/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "237", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 18.0 +} \ No newline at end of file diff --git a/237/surgery_description.txt b/237/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4c41d8253ac8be42414aab77217dc702fa08c8f9 --- /dev/null +++ b/237/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection with hemipharyngectomy and hemiglossectomy, Neck dissection, Pedicled flap (Supraclavicular Island flap), Tracheotomy diff --git a/237/surgery_report.txt b/237/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/238/InvasionFront_CD3_block8_x3_y9_patient238_0.json b/238/InvasionFront_CD3_block8_x3_y9_patient238_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dc873d6188a8a7e71d7062ba88a6ba2330d6ed65 --- /dev/null +++ b/238/InvasionFront_CD3_block8_x3_y9_patient238_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 32857.6, + "Num Detections": 23260, + "Num Negative": 22557, + "Num Positive": 703, + "Positive %": 3.022, + "Num Positive per mm^2": 295.52 + } +} \ No newline at end of file diff --git a/238/InvasionFront_CD3_block8_x4_y9_patient238_1.json b/238/InvasionFront_CD3_block8_x4_y9_patient238_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c8c5798f7d468420d9848a12c8801413ce4a9e9d --- /dev/null +++ b/238/InvasionFront_CD3_block8_x4_y9_patient238_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 32932.6, + "Num Detections": 26114, + "Num Negative": 24856, + "Num Positive": 1258, + "Positive %": 4.817, + "Num Positive per mm^2": 528.33 + } +} \ No newline at end of file diff --git a/238/InvasionFront_CD8_block8_x3_y9_patient238_0.json b/238/InvasionFront_CD8_block8_x3_y9_patient238_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3dc6a53910eb0ec02449d442cd38885adcf8d091 --- /dev/null +++ b/238/InvasionFront_CD8_block8_x3_y9_patient238_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 22937.9, + "Num Detections": 21151, + "Num Negative": 18633, + "Num Positive": 2518, + "Positive %": 11.9, + "Num Positive per mm^2": 1097.0 + } +} \ No newline at end of file diff --git a/238/InvasionFront_CD8_block8_x4_y9_patient238_1.json b/238/InvasionFront_CD8_block8_x4_y9_patient238_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cf594c679e6524c27f953225fe63ab0ad62a5ce0 --- /dev/null +++ b/238/InvasionFront_CD8_block8_x4_y9_patient238_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 23137.7, + "Num Detections": 23399, + "Num Negative": 21910, + "Num Positive": 1489, + "Positive %": 6.364, + "Num Positive per mm^2": 674.19 + } +} \ No newline at end of file diff --git a/238/TumorCenter_CD3_block8_x3_y9_patient238_0.json b/238/TumorCenter_CD3_block8_x3_y9_patient238_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d75eb2702e3e5a086dfa8f8d297f69181dd745fc --- /dev/null +++ b/238/TumorCenter_CD3_block8_x3_y9_patient238_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12618.3, + "Centroid Y µm": 23487.6, + "Num Detections": 25074, + "Num Negative": 24227, + "Num Positive": 847, + "Positive %": 3.378, + "Num Positive per mm^2": 367.29 + } +} \ No newline at end of file diff --git a/238/TumorCenter_CD3_block8_x4_y9_patient238_1.json b/238/TumorCenter_CD3_block8_x4_y9_patient238_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6f63205c33bc886169a498b7a8dc258c6b0ef64b --- /dev/null +++ b/238/TumorCenter_CD3_block8_x4_y9_patient238_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15117.0, + "Centroid Y µm": 23037.8, + "Num Detections": 17522, + "Num Negative": 15812, + "Num Positive": 1710, + "Positive %": 9.759, + "Num Positive per mm^2": 949.32 + } +} \ No newline at end of file diff --git a/238/TumorCenter_CD8_block8_x3_y9_patient238_0.json b/238/TumorCenter_CD8_block8_x3_y9_patient238_0.json new file mode 100644 index 0000000000000000000000000000000000000000..763bd86e9006734199ac0a46767cd2a8d3513207 --- /dev/null +++ b/238/TumorCenter_CD8_block8_x3_y9_patient238_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12218.5, + "Centroid Y µm": 23012.8, + "Num Detections": 25952, + "Num Negative": 24694, + "Num Positive": 1258, + "Positive %": 4.847, + "Num Positive per mm^2": 529.77 + } +} \ No newline at end of file diff --git a/238/TumorCenter_CD8_block8_x4_y9_patient238_1.json b/238/TumorCenter_CD8_block8_x4_y9_patient238_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e88061f0d24b02fafed55eff17d15127d65fb963 --- /dev/null +++ b/238/TumorCenter_CD8_block8_x4_y9_patient238_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14767.2, + "Centroid Y µm": 22887.9, + "Num Detections": 22735, + "Num Negative": 21229, + "Num Positive": 1506, + "Positive %": 6.624, + "Num Positive per mm^2": 699.19 + } +} \ No newline at end of file diff --git a/238/history_text.txt b/238/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7c6486bccad305aaab5b995d630185cdc9dbeef --- /dev/null +++ b/238/history_text.txt @@ -0,0 +1 @@ +During a biopsy, a p16-positive squamous cell carcinoma was histologically confirmed externally in the area of the soft palate on the left. Preoperative CT showed a cT1 cN0 cM0 uvula/oropharyngeal carcinoma on the left side. Sonography also showed a cN0 neck status. There is now an indication for panendoscopy and tumor resection. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/238/icd_codes.txt b/238/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed7f209dbd0540e68399df37e33c3572032cab10 --- /dev/null +++ b/238/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des weichen Gaumens[C05.1 L] \ No newline at end of file diff --git a/238/ops_codes.txt b/238/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..eb836ea760e07d2f6705b4a6a3c2328f2a948fae --- /dev/null +++ b/238/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Epipharyngoskopie[1-611.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] \ No newline at end of file diff --git a/238/patient_clinical_data.json b/238/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5db1fe74707bf37d4fc9eb05763cda2b64b162a9 --- /dev/null +++ b/238/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 16, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/238/patient_pathological_data.json b/238/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9565f56072e3524c087426029116ab14631bf83c --- /dev/null +++ b/238/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "238", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/238/surgery_description.txt b/238/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..20a46b21899a6e8d327798255ab9fd0e3c7fd003 --- /dev/null +++ b/238/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Panendoscopy diff --git a/238/surgery_report.txt b/238/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5914400f6f67cf24f21f7a4791ed6c3b4a0c20e0 --- /dev/null +++ b/238/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesiologist. Induction of anesthesia. Transition to tracheoscopy: problem-free passage of the non-irritated glottis and endotracheal entry. Mucosal conditions are normal on all sides up to the tracheal bifurcation. Intubation of the patient. Transition to esophagogastroscopy: insertion of the endoscope under visualization and constant air insufflation into the stomach. Insufflation of the same. This reveals a typical gastric mucosal relief without irritation on all sides. Occasionally, small, broad-based polyps can be seen in the area of the large curvature. Inversion and inspection of the gastroesophageal junction. This appears to be altered in a reflux-like manner. After desufflation, slow withdrawal of the endoscope with circular inspection of all sections of the esophagus. This reveals leukoplakic-like changes to the mucosa, particularly in the distal and cervical sections, which cannot be flushed away. Both the gastric polyps and the esophageal findings should be checked gastroenterologically at intervals. Then insert the mouth guard and enter with the size C small bore tube. Adjustment of the endolarynx. Mucosal conditions are normal on all sides. Enter the piriform sinus on both sides. This is lined with smooth mucosa on all sides and can be seen freely up to the tip of the piriform sinus. There is also no evidence of a tumor postcricoidally or in the area of the esophageal opening. Adjustment of the findings described above using the McIvor oral spatula. This shows the exophytically growing mass in the area of the left soft palate. The main tumor mass appears to be localized on the posterior surface of the velum. Medially, the tumor growth extends over the posterior surface across the base of the uvula to the opposite right side, where it only reaches the anterior palatal arch. Laterally to the left, the tumor extends macroscopically to the upper tonsil pole. Velotractio is applied in the typical manner and the posterior surface of the velum is inspected. The tubes appear free on both sides. The tumor does not extend very far cranially on the posterior surface of the velum. Hence the decision to resect the tumor. As the tumor grows macroscopically on the posterior surface of the uvula to the opposite right side, the decision is made to resect the uvula completely. Starting parauvularly on the right and resection of the tumor with an electric needle and pointed scissors. The tumor can thus be exposed well and resected macroscopically in sano. In the area of the anterior palatal arch on the left side, a resection specimen is taken with macroscopically close in sano resection. The main specimen is thread-marked at the corresponding site. A biopsy is also taken in the area of the left caudal tonsil lobe. The mucosa here also appears to be leukoplakically altered. Hemostasis by means of bipolar coagulation and insertion of H2O2-soaked ball swabs. If the wound bed is dry, the operation is completed without complications. Final consultation with the anesthesiologist. Due to the growth crossing the midline, a neck dissection should be planned on both sides during the inpatient stay. The placement of a PEG feeding tube was deliberately avoided for the time being. \ No newline at end of file diff --git a/239/InvasionFront_CD3_block7_x3_y5_patient239_0.json b/239/InvasionFront_CD3_block7_x3_y5_patient239_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dc3bd1e2746e6714c9a055f592ab29e66ad7ae03 --- /dev/null +++ b/239/InvasionFront_CD3_block7_x3_y5_patient239_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11419.0, + "Centroid Y µm": 12168.6, + "Num Detections": 18772, + "Num Negative": 18450, + "Num Positive": 322, + "Positive %": 1.715, + "Num Positive per mm^2": 129.74 + } +} \ No newline at end of file diff --git a/239/InvasionFront_CD3_block7_x4_y5_patient239_1.json b/239/InvasionFront_CD3_block7_x4_y5_patient239_1.json new file mode 100644 index 0000000000000000000000000000000000000000..81bd47e55e8fd8244db3f3f39a18710cf00ce1cc --- /dev/null +++ b/239/InvasionFront_CD3_block7_x4_y5_patient239_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 12168.6, + "Num Detections": 19528, + "Num Negative": 19395, + "Num Positive": 133, + "Positive %": 0.6811, + "Num Positive per mm^2": 55.72 + } +} \ No newline at end of file diff --git a/239/InvasionFront_CD3_block7_x5_y5_patient239_2.json b/239/InvasionFront_CD3_block7_x5_y5_patient239_2.json new file mode 100644 index 0000000000000000000000000000000000000000..748921a95beb515a4449d88949d3d938b1b22d7e --- /dev/null +++ b/239/InvasionFront_CD3_block7_x5_y5_patient239_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 12118.6, + "Num Detections": 26934, + "Num Negative": 23580, + "Num Positive": 3354, + "Positive %": 12.45, + "Num Positive per mm^2": 1360.4 + } +} \ No newline at end of file diff --git a/239/InvasionFront_CD3_block7_x6_y5_patient239_3.json b/239/InvasionFront_CD3_block7_x6_y5_patient239_3.json new file mode 100644 index 0000000000000000000000000000000000000000..bbfa5ee7b9043d3376d1249d27314600419862ea --- /dev/null +++ b/239/InvasionFront_CD3_block7_x6_y5_patient239_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 12118.6, + "Num Detections": 26111, + "Num Negative": 23114, + "Num Positive": 2997, + "Positive %": 11.48, + "Num Positive per mm^2": 1209.9 + } +} \ No newline at end of file diff --git a/239/InvasionFront_CD8_block7_x3_y5_patient239_0.json b/239/InvasionFront_CD8_block7_x3_y5_patient239_0.json new file mode 100644 index 0000000000000000000000000000000000000000..069220521b0fd0eb6e4fb9e976b1923a6ecb486f --- /dev/null +++ b/239/InvasionFront_CD8_block7_x3_y5_patient239_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12781.1, + "Centroid Y µm": 12865.6, + "Num Detections": 17719, + "Num Negative": 17710, + "Num Positive": 9, + "Positive %": 0.0508, + "Num Positive per mm^2": 3.868 + } +} \ No newline at end of file diff --git a/239/InvasionFront_CD8_block7_x4_y5_patient239_1.json b/239/InvasionFront_CD8_block7_x4_y5_patient239_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0351e1ee0dbf181baf083b4f438be10b0cf5615c --- /dev/null +++ b/239/InvasionFront_CD8_block7_x4_y5_patient239_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15316.9, + "Centroid Y µm": 13193.0, + "Num Detections": 19435, + "Num Negative": 19300, + "Num Positive": 135, + "Positive %": 0.6946, + "Num Positive per mm^2": 58.13 + } +} \ No newline at end of file diff --git a/239/InvasionFront_CD8_block7_x5_y5_patient239_2.json b/239/InvasionFront_CD8_block7_x5_y5_patient239_2.json new file mode 100644 index 0000000000000000000000000000000000000000..5af034238b607249a3fce3531c7b3a207be885af --- /dev/null +++ b/239/InvasionFront_CD8_block7_x5_y5_patient239_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17815.6, + "Centroid Y µm": 13467.9, + "Num Detections": 29290, + "Num Negative": 27170, + "Num Positive": 2120, + "Positive %": 7.238, + "Num Positive per mm^2": 872.16 + } +} \ No newline at end of file diff --git a/239/InvasionFront_CD8_block7_x6_y5_patient239_3.json b/239/InvasionFront_CD8_block7_x6_y5_patient239_3.json new file mode 100644 index 0000000000000000000000000000000000000000..e2cdb935bd1c2a246d542103768b4d3bb1c519e8 --- /dev/null +++ b/239/InvasionFront_CD8_block7_x6_y5_patient239_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20464.2, + "Centroid Y µm": 13642.8, + "Num Detections": 25752, + "Num Negative": 23093, + "Num Positive": 2659, + "Positive %": 10.33, + "Num Positive per mm^2": 1096.3 + } +} \ No newline at end of file diff --git a/239/TumorCenter_CD3_block7_x3_y5_patient239_0.json b/239/TumorCenter_CD3_block7_x3_y5_patient239_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b42bf42f8495a33b13d7b2511158dcc779861ce8 --- /dev/null +++ b/239/TumorCenter_CD3_block7_x3_y5_patient239_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 12593.3, + "Num Detections": 19414, + "Num Negative": 19076, + "Num Positive": 338, + "Positive %": 1.741, + "Num Positive per mm^2": 134.21 + } +} \ No newline at end of file diff --git a/239/TumorCenter_CD3_block7_x4_y5_patient239_1.json b/239/TumorCenter_CD3_block7_x4_y5_patient239_1.json new file mode 100644 index 0000000000000000000000000000000000000000..89c4c8ca723e72e8c903067f3a76a0a7948f00ca --- /dev/null +++ b/239/TumorCenter_CD3_block7_x4_y5_patient239_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 12568.3, + "Num Detections": 15923, + "Num Negative": 15621, + "Num Positive": 302, + "Positive %": 1.897, + "Num Positive per mm^2": 145.79 + } +} \ No newline at end of file diff --git a/239/TumorCenter_CD3_block7_x5_y5_patient239_2.json b/239/TumorCenter_CD3_block7_x5_y5_patient239_2.json new file mode 100644 index 0000000000000000000000000000000000000000..dac71daaa6383b44d92dede2d427f0fc5706da23 --- /dev/null +++ b/239/TumorCenter_CD3_block7_x5_y5_patient239_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 12643.3, + "Num Detections": 9071, + "Num Negative": 7154, + "Num Positive": 1917, + "Positive %": 21.13, + "Num Positive per mm^2": 1736.2 + } +} \ No newline at end of file diff --git a/239/TumorCenter_CD3_block7_x6_y5_patient239_3.json b/239/TumorCenter_CD3_block7_x6_y5_patient239_3.json new file mode 100644 index 0000000000000000000000000000000000000000..204b3a1c7c63594a7780e4220840eaed03682126 --- /dev/null +++ b/239/TumorCenter_CD3_block7_x6_y5_patient239_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 12668.3, + "Num Detections": 21144, + "Num Negative": 20260, + "Num Positive": 884, + "Positive %": 4.181, + "Num Positive per mm^2": 394.97 + } +} \ No newline at end of file diff --git a/239/TumorCenter_CD8_block7_x3_y5_patient239_0.json b/239/TumorCenter_CD8_block7_x3_y5_patient239_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6ac41e1fb5e664913ffe74bf2f74bcac1ff18376 --- /dev/null +++ b/239/TumorCenter_CD8_block7_x3_y5_patient239_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 12643.3, + "Num Detections": 22230, + "Num Negative": 22204, + "Num Positive": 26, + "Positive %": 0.117, + "Num Positive per mm^2": 10.25 + } +} \ No newline at end of file diff --git a/239/TumorCenter_CD8_block7_x4_y5_patient239_1.json b/239/TumorCenter_CD8_block7_x4_y5_patient239_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b347b67a08fcf70a2ec94be7b5fcdde789205928 --- /dev/null +++ b/239/TumorCenter_CD8_block7_x4_y5_patient239_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 12618.3, + "Num Detections": 20884, + "Num Negative": 20854, + "Num Positive": 30, + "Positive %": 0.1437, + "Num Positive per mm^2": 12.38 + } +} \ No newline at end of file diff --git a/239/TumorCenter_CD8_block7_x5_y5_patient239_2.json b/239/TumorCenter_CD8_block7_x5_y5_patient239_2.json new file mode 100644 index 0000000000000000000000000000000000000000..80c590fda060169244f3096d533e743cd4bba5da --- /dev/null +++ b/239/TumorCenter_CD8_block7_x5_y5_patient239_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 12718.3, + "Num Detections": 25137, + "Num Negative": 23987, + "Num Positive": 1150, + "Positive %": 4.575, + "Num Positive per mm^2": 478.49 + } +} \ No newline at end of file diff --git a/239/TumorCenter_CD8_block7_x6_y5_patient239_3.json b/239/TumorCenter_CD8_block7_x6_y5_patient239_3.json new file mode 100644 index 0000000000000000000000000000000000000000..e79e237f6e873e08e342f119f75efa7fe2efe1de --- /dev/null +++ b/239/TumorCenter_CD8_block7_x6_y5_patient239_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 12718.3, + "Num Detections": 24549, + "Num Negative": 24126, + "Num Positive": 423, + "Positive %": 1.723, + "Num Positive per mm^2": 170.73 + } +} \ No newline at end of file diff --git a/239/history_text.txt b/239/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3686a31a220be6b6a063958ceaa49ae4705064b5 --- /dev/null +++ b/239/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT3 cN1 G3 oropharyngeal carcinoma on the left was evaluated as part of a panendoscopy on <2013>, which had already been histologically confirmed externally. The patient was also found to have CLL with manifestations in the vallecula area. However, no further measures were required here. In our interdisciplinary tumor conference, primary surgical treatment was indicated. Preoperative sonography revealed a neck status of at least cN2b on the left side with conspicuous nodules in level Ia. After radial artery harvesting in the area of the left forearm, there were limited possibilities for graft harvesting. \ No newline at end of file diff --git a/239/icd_codes.txt b/239/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..22ac9d327390ac336b814fa425ce8729386048ab --- /dev/null +++ b/239/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/239/ops_codes.txt b/239/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9b3e04f36a4978e43b1102cfe64979cd1a683ac6 --- /dev/null +++ b/239/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.14 ] Transplantat[5-295.14 ] Transorale Tumortonsillektomie[5-281.2 ] Transorale Tumortonsillektomie[5-281.2 ] Partielle Glossektomie durch Pharyngotomie sonstige[5-251.2x ] Partielle Glossektomie durch Pharyngotomie sonstige[5-251.2x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Entnahme eines fasziokutanen Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-858.08 R] Entnahme eines fasziokutanen Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-858.08 R] Freier Lappen mit mikrovaskuläre Anastomose Haut und Unterhaut Empfängerstelle Hals[5-905.05 ] Freier Lappen mit mikrovaskuläre Anastomose Haut und Unterhaut Empfängerstelle Hals[5-905.05 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Permanente Tracheostomaanlage[5-312.0 ] Permanente Tracheostomaanlage[5-312.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Sonstige diagnostische Pharyngoskopie[1-611.x ] \ No newline at end of file diff --git a/239/patient_clinical_data.json b/239/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c83f51fd465282e824955d0a2af926b6bdca6c73 --- /dev/null +++ b/239/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/239/patient_pathological_data.json b/239/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6fe4dc1a13d39451fc584399090c0d68fa74d388 --- /dev/null +++ b/239/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "239", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/239/surgery_description.txt b/239/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bdf42ac892f5634b112ce0961e4392e42e387db9 --- /dev/null +++ b/239/surgery_description.txt @@ -0,0 +1 @@ +Pharyngeal partial resection, Neck dissection, Free flap coverage (ALT) diff --git a/239/surgery_report.txt b/239/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cdc44bf492658faee8ff68672c912884c42667ae --- /dev/null +++ b/239/surgery_report.txt @@ -0,0 +1 @@ +After intubation by the anesthesia colleagues and preparation for the procedure, pharyngoscopy is performed to determine the extent of the mass. An exophytic mass was found in the area of the left tonsillar lobe. Infiltration of the anterior and posterior palatal arch. Growth over the glossotonsillar groove into the edge and base of the tongue with palpatory submucosal growth towards the posterior floor of the mouth, overall cT3, therefore primarily transoral resection. Incision of the tumor with a safety margin of a good 1 cm, including the anterior and posterior palatal arch. Resection in a parauvular direction. In the case of deep infiltration, expose the pterygoid muscles. Inclusion of the posterior palatal arch and here also the muscles basally here in sano. Resection up to the alveolar ridge, here small tumor extension, therefore circumscribed bone exposure in the area of the posterior mandible. Detachment of the periosteum here. Now resection towards the posterior floor of the mouth, here the tongue shows submucosal infiltration at the edge and base of the tongue. Resect the base of the tongue generously while maintaining a safety distance of at least 1.5 cm. Release of the tongue section. It is now apparent that the tumor has grown submucosally over the posterior floor of the mouth towards the cervical region, with insufficient control, so that the combined procedure via a transcervical approach is now decided upon. Imaging of the entire enoral tumor in the area of the mucosal margins as well as basally with margin samples, these are diagnosed as completely tumor-free. Then turn to the transcervical approach. Skin incision at the anterior edge of the sternocleidomastoid muscle. A rough, hard mass can be palpated in depth at the cranial edge of the sternocleidomastoid muscle. The same applies to levels II and Ia. Cut through skin and subcutaneous tissue. Expose and dissect the platysma. Dissection of the platysma. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle, exposure of the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the superior thyroid artery and the superior thyroid vein, which is very strong here. Cranial dissection of the sternocleidomastoid muscle shows clear infiltration. Therefore, the muscle is removed at the level of the omohyoid muscle, cranial dissection with the neck preparation up to level Vb with numerous nodes, targeted ligation of the thoracic duct. After visualization, no evidence of lymphatic leakage. Cranial dissection, caudal preservation of the cervical plexus. Cranially, the metastasis is markedly coarse and hard to palpate, firmly infiltrating the surrounding tissue. Involvement of the sternocleidomastoid muscle up to its cranial origin. Involvement of paravertebral musculature. Resection of the accessorius nerve with parts of the cervical plexus. Dissection of the internal jugular vein, which is clearly infiltrated cranially. Retention of the outlet of the superior thyroid vein. In the case of extensive perinodally growing metastasis or soft tissue metastasis, the .............. The internal jugular vein as well as the vagus nerve, the carotid bulb and the branches of the external and internal carotid arteries are also surrounded by tumors. Clear infiltration of the hypoglossal nerve. Careful dissection of the common carotid artery and the carotid bulb with dissection of the perivascular tissue allows the tumor to be removed in toto from the carotid bulb and the internal carotid artery. No wall infiltration, but long-lasting involvement of the internal carotid artery. With removal of the entire perivascular tissue and resection of the structures already described as well as resection of the caudal parotid pole, a mass can now be resected in toto. Resection, the mass moves under the digastric muscle in the direction of the tonsillar lobe. Now there is no complete tumor growth, so that a direct metastatic pathway is present. Tumor infiltration towards the muscles of the floor of the mouth is now also evident. Palpation from the outside through the primary tumor initially leads to resection of the digastric muscle, triggering of the submandibular gland, here in level Ib multiple and macroscopically highly visible masses, which are excised in toto. Exposure of the long marginal mandibular ramus, which is not infiltrated and can be preserved. Resection of the submandibular gland. Here, creation of the connection inwards to the enoral transresection margin. Final resection of the primary tumor, including the floor of the mouth, muscles and lateral pharyngeal muscles. Here in toto on all sides. A complete image of the tumor and the basal musculature is now made at the caudal site of the base of the tongue and the caudal pharyngeal wall; these are also diagnosed as completely tumor-free in the frozen section diagnosis. Overall, an R0 situation can be assumed here as far as it can be imaged using marginal samples. The anterior excision of level Ib and the excision of level Ia are now performed. Level Ia shows a highly suspicious lymph node and a further soft tissue metastasis. Release under resection of the anterior venter of the digastric muscle, resection of the metastasis with surrounding and floor muscles but without infiltration. After enoral complete evacuation of level Ia. Careful inspection of the wound area. Overall dry conditions. The lingual artery was removed. Likewise, outlets of the facial artery, otherwise existing arterial supply and existing caudal internal jugular vein with ultimately remaining tributaries of the superior thyroid and middle thyroid vein. Subsequently, parallel neck dissection of the right side and elevation of the antero-lateral thigh graft from the right after measurement of the defect and confirmation of the R0 situation. First to the neck dissection on the right. This also involves a curved incision at the anterior edge of the sternocleidomatoid muscle, cutting through the skin and subcutaneous tissue. Exposure and dissection of the platysma. Exposure of the sternocleidomastoid and omohyoid muscles. Exposure of the submandibular gland and digastric muscle. Removal of the anterior neck preparation with careful protection of the cervical vein, the facial vein, the superior thyroid artery and the hypoglossal nerve. Free preparation of the internal jugular vein. Exposure of the accessorius nerve, clearing of the accessorius triangle and clearing of level V with careful protection of the cervical plexus branches. In level II, conspicuous nodes also paraglandular in the area of the submandibular gland, several nodes clearly suspicious in number and size. Release of the submandibular gland. Clearing of level Ib, exposure of the marginal mandibular ridge and careful protection of the nerve. Complete evacuation of level Ib, macroscopically highly conspicuous nodes in number and size. Complete the dissection to level Ia. Finally, extensive wound irrigation and, if the wound is dry, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Then turn to the plastic tracheotomy: To do this, make a horizontal skin incision approx. 1 cm below the cricoid cartilage. Cut through skin and subcutaneous tissue. Ligation of the left-sided anterior jugular vein. Entering the linea alba, exposing the cricoid cartilage, exposing the anterior wall of the trachea. Dissection of the slender thyroid isthmus. Further exposure of the anterior wall of the trachea. Insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björk flap. Subsequent successive insertion of the tracheostoma. Subsequent problem-free intubation onto a size 9 low cuff cannula, which is suture-fixed. Now to lift the anterolateral thigh graft. After marking the landmarks, double sonographic identification of the main perforator and 2 secondary perforators. Marking of the graft configured for the tonsil lobe, pharyngeal side wall and tongue, measuring approx. 11 x 9 cm in total. Medial incision. Separation of skin and subcutaneous tissue, exposure of the facia lata, reliable identification of the rectus femoris muscle, strictly subfascial preparation. Visualization of the pedicle vessel. Inspection reveals the sonographically visualized perforators which, however, are extremely slender. Execution of the relief incision and further exposure of the pedicle vessel. Complete resection of the graft, including the fascia lata. In the case of a circumscribed myocutaneous course of the perforators, a narrow muscle strip is removed after identification of the distal vascular pedicle. After identification of the perforator level, elevation of the graft, isolation on the vascular pedicle. Dissection of the vascular pedicle, visualization of a venous confluence. Exposure of the transverse ramus. Subsequently, if the graft is in proper vitality, the graft is removed after ligation of the feeding and draining vessels. Careful wound inspection and, if the wound is dry, insertion of a 10-gauge Redon drainage and then careful multi-layer wound closure with smoothing of excess skin. The combined transoral and transcervical insertion of the graft is now performed. Overall extremely good fit and intact conditions on all sides. Reconstruction of the soft palate, the tonsil lobe, the pharyngeal side wall and the base and edge of the tongue, as well as the posterior floor of the mouth. Conditioning of the superior thyroid artery and the superior thyroid vein. Perform the arterial anastomosis using the single suture technique with 8-0 Ethilon. This succeeds immediately without any problems. Regular venous return and vital graft. Performing the venous anastomosis with the coupler system using a size 3.5 coupler. Finally, regular circulation, good pedicle pulsation as well as a positive smear test and a regularly vital graft enorally, so that after a final wound inspection a 10 redon drain is inserted and the wound is carefully closed in two layers. During the recovery phase, a moderate degree of ballooning of the neck becomes apparent if the right Redon drainage is not pumped, so re-exploration is performed at the end. Removal of the hematoma, hemostasis in the area of smaller muscle vessels, careful wound irrigation with H202 and Ringer's solution and, if the wound was absolutely dry, re-insertion of a 10-gauge Redon drain and careful two-layer wound closure and completion of the procedure with a vital graft. The patient received intraoperative intravenous antibiotics with clindamycin 600 mg, which should be continued for 24 hours postoperatively. If possible, leave the suture-fixed cannula in place for 5 days postoperatively. Carry out an X-ray pre-swallow on the 10th postoperative day, then evaluate the swallowing function. Due to the radical tumor resection and the extended radical neck dissection on the left with resection of the vagus nerve and hypoglossal nerve, a protracted recovery of swallowing function can be expected here. Overall intraoperative R0 resected, at least cT3 cN2c oropharyngeal carcinoma on the left with clear soft tissue metastasis and multiple conspicuous nodes, especially level Ia and level Ib on both sides. Rapid initiation of adjuvant RCT appears to be urgently required here. \ No newline at end of file diff --git a/240/InvasionFront_CD8_block6_x3_y11_patient240_0.json b/240/InvasionFront_CD8_block6_x3_y11_patient240_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f405c291250d037bc4d4095cd223f098edb94ff --- /dev/null +++ b/240/InvasionFront_CD8_block6_x3_y11_patient240_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 27785.3, + "Num Detections": 16805, + "Num Negative": 16594, + "Num Positive": 211, + "Positive %": 1.256, + "Num Positive per mm^2": 102.66 + } +} \ No newline at end of file diff --git a/240/InvasionFront_CD8_block6_x4_y11_patient240_1.json b/240/InvasionFront_CD8_block6_x4_y11_patient240_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd1a0c437c4b93d19157deabacec57c34e26a99d --- /dev/null +++ b/240/InvasionFront_CD8_block6_x4_y11_patient240_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13992.6, + "Centroid Y µm": 27960.2, + "Num Detections": 23274, + "Num Negative": 23238, + "Num Positive": 36, + "Positive %": 0.1547, + "Num Positive per mm^2": 15.03 + } +} \ No newline at end of file diff --git a/240/TumorCenter_CD3_block6_x3_y11_patient240_0.json b/240/TumorCenter_CD3_block6_x3_y11_patient240_0.json new file mode 100644 index 0000000000000000000000000000000000000000..21f2ed3a4293571e6a60fa0a618581b41ff291bf --- /dev/null +++ b/240/TumorCenter_CD3_block6_x3_y11_patient240_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11369.0, + "Centroid Y µm": 28010.2, + "Num Detections": 20451, + "Num Negative": 18179, + "Num Positive": 2272, + "Positive %": 11.11, + "Num Positive per mm^2": 1076.4 + } +} \ No newline at end of file diff --git a/240/TumorCenter_CD3_block6_x4_y11_patient240_1.json b/240/TumorCenter_CD3_block6_x4_y11_patient240_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2d161b48004856ea380eb20e6537814c0a6c0973 --- /dev/null +++ b/240/TumorCenter_CD3_block6_x4_y11_patient240_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 27960.2, + "Num Detections": 17828, + "Num Negative": 14601, + "Num Positive": 3227, + "Positive %": 18.1, + "Num Positive per mm^2": 1665.2 + } +} \ No newline at end of file diff --git a/240/TumorCenter_CD8_block6_x3_y11_patient240_0.json b/240/TumorCenter_CD8_block6_x3_y11_patient240_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a75adb4024578905de772eccb7ac7a4f21339fb0 --- /dev/null +++ b/240/TumorCenter_CD8_block6_x3_y11_patient240_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 28385.0, + "Num Detections": 21257, + "Num Negative": 20213, + "Num Positive": 1044, + "Positive %": 4.911, + "Num Positive per mm^2": 491.16 + } +} \ No newline at end of file diff --git a/240/TumorCenter_CD8_block6_x4_y11_patient240_1.json b/240/TumorCenter_CD8_block6_x4_y11_patient240_1.json new file mode 100644 index 0000000000000000000000000000000000000000..81b27b51567a2334d21bedcf7a9a3c3b6c3e64cd --- /dev/null +++ b/240/TumorCenter_CD8_block6_x4_y11_patient240_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 28459.9, + "Num Detections": 19303, + "Num Negative": 17351, + "Num Positive": 1952, + "Positive %": 10.11, + "Num Positive per mm^2": 950.13 + } +} \ No newline at end of file diff --git a/240/history_text.txt b/240/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa280d77b71ede7a164720b888c4f3d82742e729 --- /dev/null +++ b/240/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the right. Therefore, the above-mentioned surgery is now indicated. Another endoscopic examination was indicated to clarify the question of whether laser resection is possible or an external approach. Patient was also informed about defect coverage by means of flap plasty. \ No newline at end of file diff --git a/240/icd_codes.txt b/240/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1a0603b1779785fcd6e13a9976159c37231ecdc2 --- /dev/null +++ b/240/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] \ No newline at end of file diff --git a/240/ops_codes.txt b/240/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9cc7c7ae7013afa01f984f267a7e2b7170a161b6 --- /dev/null +++ b/240/ops_codes.txt @@ -0,0 +1 @@ +Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Temporäre Tracheotomie[5-311.0 ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie ohne Rekonstruktion[5-295.10 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Partielle Larynx-Pharynx-Resektion[5-302.4 ] \ No newline at end of file diff --git a/240/patient_clinical_data.json b/240/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..52cd8dd02adea85574428201766064810119734a --- /dev/null +++ b/240/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/240/patient_pathological_data.json b/240/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8bcb2a3d043ab10540f0706aeb1c23284bdb219f --- /dev/null +++ b/240/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "240", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 34, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris1", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.6", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/240/surgery_description.txt b/240/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc893559adf8fa6cda10f2efe6eb3d61fc962cd2 --- /dev/null +++ b/240/surgery_description.txt @@ -0,0 +1 @@ +Resection transversely through the neck, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/240/surgery_report.txt b/240/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cee8890699db48c4e95d5cb02c7b210b46a2a64e --- /dev/null +++ b/240/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Induction of anesthesia by the anesthesia colleagues. Pharyngoscopy and laryngoscopy again: insertion of the size B small bore tube. A small exulcerated tumor can be seen in the area of the anterior piriform sinus wall up to the border of the lateral wall. However, this shows a deep ulcer, so that a risk-free laser resection ultimately does not appear to be possible with pulsations on the lateral wall. The decision was therefore made to proceed transcervically. Initial PEG insertion: insertion with the flexible esophagoscope. Advance into the stomach. After creating the diaphanoscopy and sterile covering of the abdomen, insertion of an abdominal wall probe using a typical technique in a typical manner. Sterile fixation to the abdominal wall. Repositioning for neck dissection and tumor resection. The patient is also prepared for radial lobectomy. Therefore, all relevant surgical areas are covered. Injection of Ultracaine 1% with adrenaline 10 ml into both sides of the neck. Start with neck dissection level II to V on the right: skin incision in typical manner. Exposure of the sternocleidomastoid muscle. Exposure of the digastric and omohyoid muscles and the infrahyoid muscles. Dissection of the fat-lymph node package. Exposure of the cervical vascular sheath. Exposure of the internal jugular vein, facial vein. Exposure of the internal/external carotid artery, superior thyroid artery and facial artery. Exposure, displacement and at the end of the operation re-embedding of the hypoglossal nerve, vagus nerve, accessorius nerve, branches of the cervical plexus and the border cord in the sense of a neurolysis. Lymph nodes are firmly attached to the vessels in the upper area, but can be dissected, even in depth, and dissected from the border cord. Level II to V dissection is performed while preserving all structures. Neck dissection on the left: This is performed in the same way as on the opposite side. Here too, all structures are preserved as on the opposite side. Then tumor resection: Exposure of the hyoid bone, which is also resected laterally. Exposure and resection of the upper horn of the larynx. Mobilization of the pharyngeal tube. Entering the pharynx just below the hyoid bone at the level of the epiglottis. The tumor can be visualized. This is resected with a safety margin of at least 1 cm on all sides, macroscopically in healthy tissue. Resection includes the anterior piriform sinus and parts of the lateral wall. As the tumor has its deepest ulcer basally in the direction of the thyroid cartilage, the lateral thyroid cartilage is also resected and is attached basally to the specimen. The superior laryngeal nerve can also not be preserved in direct contact with the tumor. The specimen is then marked with sutures and sent in. In addition, a marginal sample is taken from the medial area. A strip is taken from the area of the arytenoid fold down to the piriform sinus. The frozen section shows that the tumor has been removed from the healthy area. However, carcinoma in situ can still be seen in some places in the medially removed marginal sample. A further resection is recommended here. Therefore, another resection of an almost 1 cm wide mucosal strip from the area of the arytenoid fold is performed, whereby the border to the postcricoid area is already reached. The frozen section still shows very clear carcinoma in situ infiltrates in most areas with a transition to microinvasive carcinoma in some places. Based on the overall situation, field carcinomatization can now be assumed in the entire hypopharyngeal region. At the very least, this cannot be ruled out. A further resection in the direction of the postcricoid area would in any case be accompanied by significant dysphagia and possibly necessitate a laryngectomy. However, this was not discussed in detail with the patient in advance. Therefore, the decision was made not to perform a further resection. The pharynx is closed using 3-0 Vicryl single button sutures, whereby the mucosa is closed directly in the lower area to the piriform sinus, and in the upper area the mucosa is sutured to the inside of the residual thyroid cartilage. In the upper area, the mucosa is sutured again. Pharyngeal muscles are stitched over this and sutured around the thyroid cartilage to the infrahyoid muscles, suprahyoid muscles or hyoid bone. This results in a stable closure. Extensive irrigation of the entire surgical area. Careful hemostasis. Layered closure of the wound on the left with insertion of a Redon drain, on the right with insertion of two Redon drains. Application of a wound and pressure dressing on both sides. Creation of a tracheotomy: Subcutaneous tissue is prepared via a Kocher collar incision in the typical manner, veins are ligated. The thyroid isthmus is then severed. Exposure of the trachea. Thyroid isthmus is cut off. The trachea is opened like a visor flap at the typical location and an epithelialized tracheostoma is created. Finally, an 8 mm tracheal cannula is inserted after removal of the laryngectomy tube. Application of a wound dressing. Subsequent completion of the procedure without complications. Final consultation with the anesthesia department. The patient is transferred to the intensive care unit for monitoring. Here, please continue the antibiotic treatment that was started preoperatively with Unacid for a further week. Nutrition via the inserted PEG tube. Wait for the final histology. According to the current state of knowledge, field carcinomatization is present, particularly in the direction of the postcricoid area, which would ultimately necessitate a laryngectomy in the event of surgical treatment. However, due to the still microinvasive carcinoma parts, postoperative radiochemotherapy should also be discussed. \ No newline at end of file diff --git a/241/InvasionFront_CD3_block22_x5_y9_patient241_0.json b/241/InvasionFront_CD3_block22_x5_y9_patient241_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fcc8b72bb0193db4d682aaeaa29b78d2b4bebbdb --- /dev/null +++ b/241/InvasionFront_CD3_block22_x5_y9_patient241_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17091.0, + "Centroid Y µm": 34356.8, + "Num Detections": 18305, + "Num Negative": 17386, + "Num Positive": 919, + "Positive %": 5.02, + "Num Positive per mm^2": 419.67 + } +} \ No newline at end of file diff --git a/241/InvasionFront_CD3_block22_x6_y9_patient241_1.json b/241/InvasionFront_CD3_block22_x6_y9_patient241_1.json new file mode 100644 index 0000000000000000000000000000000000000000..30cd0ab31551cf47ce1b0305f5f35c5867cba5a4 --- /dev/null +++ b/241/InvasionFront_CD3_block22_x6_y9_patient241_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19814.5, + "Centroid Y µm": 34106.9, + "Num Detections": 18105, + "Num Negative": 17433, + "Num Positive": 672, + "Positive %": 3.712, + "Num Positive per mm^2": 314.4 + } +} \ No newline at end of file diff --git a/241/InvasionFront_CD8_block22_x5_y9_patient241_0.json b/241/InvasionFront_CD8_block22_x5_y9_patient241_0.json new file mode 100644 index 0000000000000000000000000000000000000000..819aa9c539c95116ebb5d557a071236f3f21c27f --- /dev/null +++ b/241/InvasionFront_CD8_block22_x5_y9_patient241_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19721.4, + "Centroid Y µm": 22329.4, + "Num Detections": 18485, + "Num Negative": 17736, + "Num Positive": 749, + "Positive %": 4.052, + "Num Positive per mm^2": 355.27 + } +} \ No newline at end of file diff --git a/241/InvasionFront_CD8_block22_x6_y9_patient241_1.json b/241/InvasionFront_CD8_block22_x6_y9_patient241_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6bdb8a54989ca749f827160b3a34a5cbe7e98c97 --- /dev/null +++ b/241/InvasionFront_CD8_block22_x6_y9_patient241_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 22258.9, + "Centroid Y µm": 22055.5, + "Num Detections": 17308, + "Num Negative": 16915, + "Num Positive": 393, + "Positive %": 2.271, + "Num Positive per mm^2": 192.39 + } +} \ No newline at end of file diff --git a/241/TumorCenter_CD3_block22_x5_y9_patient241_0.json b/241/TumorCenter_CD3_block22_x5_y9_patient241_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3ed9f9fca57bbcae4c0dd2b6008ae4727b59deb4 --- /dev/null +++ b/241/TumorCenter_CD3_block22_x5_y9_patient241_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16666.2, + "Centroid Y µm": 22887.9, + "Num Detections": 16822, + "Num Negative": 16688, + "Num Positive": 134, + "Positive %": 0.7966, + "Num Positive per mm^2": 64.12 + } +} \ No newline at end of file diff --git a/241/TumorCenter_CD3_block22_x6_y9_patient241_1.json b/241/TumorCenter_CD3_block22_x6_y9_patient241_1.json new file mode 100644 index 0000000000000000000000000000000000000000..99d79409925ea5a5a6ebd4135696905f1144c4fe --- /dev/null +++ b/241/TumorCenter_CD3_block22_x6_y9_patient241_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 22937.9, + "Num Detections": 13406, + "Num Negative": 13247, + "Num Positive": 159, + "Positive %": 1.186, + "Num Positive per mm^2": 90.7 + } +} \ No newline at end of file diff --git a/241/TumorCenter_CD8_block22_x5_y9_patient241_0.json b/241/TumorCenter_CD8_block22_x5_y9_patient241_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ff4ff8f4802cb0b86252ed4e80684271a7667128 --- /dev/null +++ b/241/TumorCenter_CD8_block22_x5_y9_patient241_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18963.2, + "Centroid Y µm": 32467.4, + "Num Detections": 17522, + "Num Negative": 17326, + "Num Positive": 196, + "Positive %": 1.119, + "Num Positive per mm^2": 92.57 + } +} \ No newline at end of file diff --git a/241/TumorCenter_CD8_block22_x6_y9_patient241_1.json b/241/TumorCenter_CD8_block22_x6_y9_patient241_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1e40f7f26b45f8597b6096e7b4d349277bcf41fd --- /dev/null +++ b/241/TumorCenter_CD8_block22_x6_y9_patient241_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21204.8, + "Centroid Y µm": 32493.6, + "Num Detections": 14377, + "Num Negative": 14319, + "Num Positive": 58, + "Positive %": 0.4034, + "Num Positive per mm^2": 31.68 + } +} \ No newline at end of file diff --git a/241/history_text.txt b/241/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fbe1973b420cd1b3f43ff6d295afd1b745dbd149 --- /dev/null +++ b/241/history_text.txt @@ -0,0 +1 @@ +The patient has hoarseness and vocal fold fixation on the left side. The panendoscopy from <2014> describes an exophytic mass on the left side of the glottis with transition to the right side. \ No newline at end of file diff --git a/241/icd_codes.txt b/241/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/241/ops_codes.txt b/241/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/241/patient_clinical_data.json b/241/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..334e3398029a702476e6341c901cad804f6aab63 --- /dev/null +++ b/241/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 56, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/241/patient_pathological_data.json b/241/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6dabcbe09e664aff6be908473a6c34c13ec30cc9 --- /dev/null +++ b/241/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "241", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.8", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/241/surgery_description.txt b/241/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3be436ffc30edcb5ffd6cb6bb5fc69dcaf177343 --- /dev/null +++ b/241/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection diff --git a/241/surgery_report.txt b/241/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fcd98613beec851b6fd4f5fb00a6b0f620628d7e --- /dev/null +++ b/241/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia and intubation by the anesthetist. Entry with the Kleinsasser tube and inspection of the glottis. Advance the microscope. An exophytic mass is seen in the area of the left vocal fold with transition to the pocket fold and extension into the subglottic slope by approx. 0.5 to 1 cm. The mass passes over the anterior commissure to the opposite side and also extends on the left side into the postcricoid region. Due to the extent of the tumor, the age of the patient and the structure of the patient, decision to perform a laryngectomy. Repositioning of the patient. Sterile washing and draping. Creation of an apron flap. Start with neck dissection on the left side. Exposure of the sternocleidomastoid muscle, the submandibular gland, the omohyoid muscle, the posterior belly of the digaster muscle. Exposure of the cervical vascular sheath. Dissection of the internal jugular vein. Release of the medial neck block. Striking the medial neck block dorsally. Release the neck levels II a to V a while sparing the plexus branches. Now expose and detach the thyroid gland from the laryngeal skeleton. Detachment of the cervical vascular sheath from the laryngeal skeleton. Exposure of the upper laryngeal bundle. Ligation of this. Exposure of the left part of the hyoid bone. Change to the opposite side. Now first expose the sternocleidomastoid muscle and the omohyoid muscle. Then exposure of the posterior belly of the digaster and exposure of the cervical vascular sheath. Exposure of the internal jugular vein. Release of the neck block in the medial area and then release of neck levels II a to V a while sparing the plexus branches and the accessorius nerve. Exposure of the thyroid gland. Detachment of the thyroid gland from the laryngeal skeleton. Exposure of the upper laryngeal bundle. Ligation of the laryngeal bundle. Exposure of the hyoid bone. Release of the hyoid bone. Detachment of the infrahyal musculature. Skeletonization of the larynx. Transition to the tracheotomy. This is placed relatively far down, between the 3rd and 4th tracheal cartilage, due to the subglottic expansion. Exposure of the anterior wall of the trachea. Insertion between the 3rd and 4th tracheal cartilage. Fixation of the skin in the caudal area to the trachea and reintubation onto a laryngectomy tube. Release of the piriform sinus first on the right side, then on the left side. Enter the pharynx just above the hyoid bone. Disluxation of the epiglottis. Incision of the pharynx along the epiglottis up to the postcricoid region on both sides. Detachment of the entire laryngeal preparation up to the trachea. Separation of the larynx below the cricoid cartilage so that the tumor is also safely removed in the subglottic region. Inspection of the specimen. The specimen is sent for final histology. Insertion of a size 8 voice valve prosthesis using the pull-through method. An esophagomyotomy is not performed as the esophagus can be passed without any problems. Then myotomy of the attachment area of the sternocleidomastoid muscle on both sides and transition to the pharyngeal suture. The pharynx is sutured over in two layers using the usual technique and then a third layer is formed by the remaining prelaryngeal muscles and soft tissue. Wait for the histology. Feeding of the patient for 10 days via the nasogastric tube and X-ray pre-swallow on the 10th postoperative day. Then, depending on the result, diet build-up. Presentation of the patient at the tumor conference. \ No newline at end of file diff --git a/242/InvasionFront_CD3_block18_x3_y5_patient242_0.json b/242/InvasionFront_CD3_block18_x3_y5_patient242_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6d5296d899709546208577143e44165b3fb12894 --- /dev/null +++ b/242/InvasionFront_CD3_block18_x3_y5_patient242_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11493.9, + "Centroid Y µm": 17165.9, + "Num Detections": 20498, + "Num Negative": 19930, + "Num Positive": 568, + "Positive %": 2.771, + "Num Positive per mm^2": 228.58 + } +} \ No newline at end of file diff --git a/242/InvasionFront_CD3_block18_x4_y5_patient242_1.json b/242/InvasionFront_CD3_block18_x4_y5_patient242_1.json new file mode 100644 index 0000000000000000000000000000000000000000..008b691184f4ed46da66420726a4096cc1e9c106 --- /dev/null +++ b/242/InvasionFront_CD3_block18_x4_y5_patient242_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13992.6, + "Centroid Y µm": 17340.8, + "Num Detections": 23603, + "Num Negative": 22766, + "Num Positive": 837, + "Positive %": 3.546, + "Num Positive per mm^2": 319.96 + } +} \ No newline at end of file diff --git a/242/InvasionFront_CD8_block18_x3_y5_patient242_0.json b/242/InvasionFront_CD8_block18_x3_y5_patient242_0.json new file mode 100644 index 0000000000000000000000000000000000000000..047b3349476ae2b37c964bb670017a2868d3eb55 --- /dev/null +++ b/242/InvasionFront_CD8_block18_x3_y5_patient242_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11568.9, + "Centroid Y µm": 20239.3, + "Num Detections": 19394, + "Num Negative": 18856, + "Num Positive": 538, + "Positive %": 2.774, + "Num Positive per mm^2": 218.73 + } +} \ No newline at end of file diff --git a/242/InvasionFront_CD8_block18_x4_y5_patient242_1.json b/242/InvasionFront_CD8_block18_x4_y5_patient242_1.json new file mode 100644 index 0000000000000000000000000000000000000000..897f4afd7aebbefa838f1ab377d0200370353a13 --- /dev/null +++ b/242/InvasionFront_CD8_block18_x4_y5_patient242_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 20264.3, + "Num Detections": 22511, + "Num Negative": 21790, + "Num Positive": 721, + "Positive %": 3.203, + "Num Positive per mm^2": 279.97 + } +} \ No newline at end of file diff --git a/242/TumorCenter_CD3_block18_x3_y5_patient242_0.json b/242/TumorCenter_CD3_block18_x3_y5_patient242_0.json new file mode 100644 index 0000000000000000000000000000000000000000..acfc540bdcf7236a08bf93d05092e0da30a70793 --- /dev/null +++ b/242/TumorCenter_CD3_block18_x3_y5_patient242_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.7, + "Centroid Y µm": 12161.3, + "Num Detections": 19708, + "Num Negative": 19410, + "Num Positive": 298, + "Positive %": 1.512, + "Num Positive per mm^2": 127.34 + } +} \ No newline at end of file diff --git a/242/TumorCenter_CD3_block18_x4_y5_patient242_1.json b/242/TumorCenter_CD3_block18_x4_y5_patient242_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1bf4c26bd159188c105963c57323c3d4aed0eebf --- /dev/null +++ b/242/TumorCenter_CD3_block18_x4_y5_patient242_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13340.8, + "Centroid Y µm": 12149.8, + "Num Detections": 20150, + "Num Negative": 19806, + "Num Positive": 344, + "Positive %": 1.707, + "Num Positive per mm^2": 140.71 + } +} \ No newline at end of file diff --git a/242/TumorCenter_CD8_block18_x3_y5_patient242_0.json b/242/TumorCenter_CD8_block18_x3_y5_patient242_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4c1c79892ba8beac84b47c2dfa6d3b07644c3c95 --- /dev/null +++ b/242/TumorCenter_CD8_block18_x3_y5_patient242_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 12843.2, + "Num Detections": 21217, + "Num Negative": 20635, + "Num Positive": 582, + "Positive %": 2.743, + "Num Positive per mm^2": 232.17 + } +} \ No newline at end of file diff --git a/242/TumorCenter_CD8_block18_x4_y5_patient242_1.json b/242/TumorCenter_CD8_block18_x4_y5_patient242_1.json new file mode 100644 index 0000000000000000000000000000000000000000..51d7296acd5e8a5cdd7fd0474bc1a8b115635bbc --- /dev/null +++ b/242/TumorCenter_CD8_block18_x4_y5_patient242_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13268.0, + "Centroid Y µm": 12893.2, + "Num Detections": 20759, + "Num Negative": 20058, + "Num Positive": 701, + "Positive %": 3.377, + "Num Positive per mm^2": 280.04 + } +} \ No newline at end of file diff --git a/242/history_text.txt b/242/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..581e2d8dc6e80db8dea30314205755f133afb8b3 --- /dev/null +++ b/242/history_text.txt @@ -0,0 +1 @@ +Patient with histologically proven CIS in the area of the anterior commissure with an extension cT1b localized exactly in the area of the anterior and middle third of the right vocal fold and in the anterior third of the left vocal fold. Therefore, indication for laryngoscopy for the purpose of planning further measures. \ No newline at end of file diff --git a/242/icd_codes.txt b/242/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/242/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/242/ops_codes.txt b/242/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..97a125c987f69a1cc00ae09549563f93e8c81856 --- /dev/null +++ b/242/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Enterale Ernährung über eine Sonde als medizinische Hauptbehandlung[8-015.0 ] \ No newline at end of file diff --git a/242/patient_clinical_data.json b/242/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..04501da8764603e47a502205f1525a572f949981 --- /dev/null +++ b/242/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/242/patient_pathological_data.json b/242/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..337b2a4a4eb31ea8342f98fe4d15aa6c4472bfa3 --- /dev/null +++ b/242/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "242", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/242/surgery_description.txt b/242/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5cfe057590252f9cf09a2d6dfdf3a6c53f17bbe6 --- /dev/null +++ b/242/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection according to Leroux Robert diff --git a/242/surgery_report.txt b/242/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..93fe9592034a9e4f3c323fb4533f65cb8253b01f --- /dev/null +++ b/242/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia and transoral endotracheal intubation by the anesthesia colleagues and positioning of the patient by the surgeon. Laryngoscopy is performed using the Kleinsasser C-tube. Adjustment of the endolaryngeal findings. This reveals an exophytic mass affecting the anterior and middle third of the right vocal fold, the entire anterior commissure and the anterior third of the left vocal fold, without narrowing of the glottis lumen. The supraglottis and the subglottis are not affected by the tumor. Therefore, due to the massive involvement of the anterior commissure, the decision was made to proceed transcervically. Skin spray disinfection. Application of local anesthesia in a skin fold directly at the level of the thyroid cartilage. Skin ablation and sterile draping. Horizontal skin incision. Separation of the subcutaneous tissue and the platysma. Formation of a subplatysmal flap up to the thyroid incisura and caudally to the cricoid cartilage. Exposure of the anterior jugular vein with its branches. Ligation of the same. Exposure of the surface of the thyroid cartilage. Exposure of the ligamentum cornicum and the bovine cartilage. First transverse incision of the corniculate ligament. Followed by a paramedian scalpel incision on the left side along the surface of the thyroid cartilage. Dissection of a perichondrium flap on both sides. Subsequent paramedian thyrotomy using a wheel and entering the endolaryngeal lumen from cranial to caudal. Dissection of the endolaryngeal soft tissue and visualization of the tumorous findings. First enter the correct subperichondrial layer. Inclusion of the endochondrium in the tumor preparation on the right side. It is then possible to remove the tumor on the right in toto. Hemostasis there using bipolar coagulation and removal of the following marginal samples on the right: subglottis on the right, anterior commissure on the right, supraglottis on the right, posteriorly towards the arytenoid cartilage on the right. Identical procedure on the left side. Inclusion of the anterior endochondrium in the tumor specimen. Resection of the specimen in toto. Removal of the following marginal samples: left subglottis, left anterior commissure, left supraglottis, posteriorly towards the left arytenoid cartilage. All eight marginal samples were found to be tumor-free by the pathology colleagues. Endolaryngeal hemostasis using bipolar coagulation and suprarenin-impregnated pointed swabs. Subsequent suture adaptation of the cornic ligament. Adaptation of a size 16 Keel placeholder after drilling holes in the thyroid cartilage. Subsequent suture adaptation of the prelaryngeal musculature in the midline. Creation of a flap. Platysma suture. Single button skin suture. Application of a steristrip dressing and a pressure bandage. Subsequent placement of a nasogastric feeding tube without any problems and completion of the procedure without complications. The patient received intraoperative Clindamycin 600 mg intravenously, which should be continued for the next 5 days. Nutrition via the nasogastric feeding tube should also be continued for a further 5 days. Please plan a control MLE and, if necessary, Keel removal in 6 weeks. \ No newline at end of file diff --git a/243/InvasionFront_CD3_block13_x5_y8_patient243_0.json b/243/InvasionFront_CD3_block13_x5_y8_patient243_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3b6cf4305231059c06cefdd07b7c4d41fc28533d --- /dev/null +++ b/243/InvasionFront_CD3_block13_x5_y8_patient243_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 19014.9, + "Num Detections": 5688, + "Num Negative": 4900, + "Num Positive": 788, + "Positive %": 13.85, + "Num Positive per mm^2": 932.78 + } +} \ No newline at end of file diff --git a/243/InvasionFront_CD3_block13_x6_y8_patient243_1.json b/243/InvasionFront_CD3_block13_x6_y8_patient243_1.json new file mode 100644 index 0000000000000000000000000000000000000000..286c05873e6585c00cd5c8545d960bb0dace3167 --- /dev/null +++ b/243/InvasionFront_CD3_block13_x6_y8_patient243_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 19114.9, + "Num Detections": 16137, + "Num Negative": 15215, + "Num Positive": 922, + "Positive %": 5.714, + "Num Positive per mm^2": 437.77 + } +} \ No newline at end of file diff --git a/243/InvasionFront_CD8_block13_x5_y8_patient243_0.json b/243/InvasionFront_CD8_block13_x5_y8_patient243_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9c0aa9e8ece53d50e684ec71f39b007684284069 --- /dev/null +++ b/243/InvasionFront_CD8_block13_x5_y8_patient243_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16866.1, + "Centroid Y µm": 20988.9, + "Num Detections": 9387, + "Num Negative": 8196, + "Num Positive": 1191, + "Positive %": 12.69, + "Num Positive per mm^2": 864.44 + } +} \ No newline at end of file diff --git a/243/InvasionFront_CD8_block13_x6_y8_patient243_1.json b/243/InvasionFront_CD8_block13_x6_y8_patient243_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e91c216b36e0c776eb81b5a6f7c27217f155eef3 --- /dev/null +++ b/243/InvasionFront_CD8_block13_x6_y8_patient243_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19539.7, + "Centroid Y µm": 21263.7, + "Num Detections": 14882, + "Num Negative": 14339, + "Num Positive": 543, + "Positive %": 3.649, + "Num Positive per mm^2": 269.1 + } +} \ No newline at end of file diff --git a/243/TumorCenter_CD3_block13_x5_y8_patient243_0.json b/243/TumorCenter_CD3_block13_x5_y8_patient243_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fe0be313b6844c270488e8588560327ee8ab3056 --- /dev/null +++ b/243/TumorCenter_CD3_block13_x5_y8_patient243_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16566.2, + "Centroid Y µm": 26685.9, + "Num Detections": 13668, + "Num Negative": 12337, + "Num Positive": 1331, + "Positive %": 9.738, + "Num Positive per mm^2": 642.65 + } +} \ No newline at end of file diff --git a/243/TumorCenter_CD3_block13_x6_y8_patient243_1.json b/243/TumorCenter_CD3_block13_x6_y8_patient243_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d7f9a6e54e186462fcbdb7a52cd3e8e4a698113d --- /dev/null +++ b/243/TumorCenter_CD3_block13_x6_y8_patient243_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 26960.7, + "Num Detections": 13840, + "Num Negative": 12495, + "Num Positive": 1345, + "Positive %": 9.718, + "Num Positive per mm^2": 707.78 + } +} \ No newline at end of file diff --git a/243/TumorCenter_CD8_block13_x5_y8_patient243_0.json b/243/TumorCenter_CD8_block13_x5_y8_patient243_0.json new file mode 100644 index 0000000000000000000000000000000000000000..81d80c632cead501309b2ec740740ccbb6704b15 --- /dev/null +++ b/243/TumorCenter_CD8_block13_x5_y8_patient243_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17215.9, + "Centroid Y µm": 19239.8, + "Num Detections": 12672, + "Num Negative": 12209, + "Num Positive": 463, + "Positive %": 3.654, + "Num Positive per mm^2": 233.85 + } +} \ No newline at end of file diff --git a/243/TumorCenter_CD8_block13_x6_y8_patient243_1.json b/243/TumorCenter_CD8_block13_x6_y8_patient243_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e2773222b73d008c4605f14918ae795913118176 --- /dev/null +++ b/243/TumorCenter_CD8_block13_x6_y8_patient243_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19789.5, + "Centroid Y µm": 18989.9, + "Num Detections": 10377, + "Num Negative": 9672, + "Num Positive": 705, + "Positive %": 6.794, + "Num Positive per mm^2": 351.7 + } +} \ No newline at end of file diff --git a/243/history_text.txt b/243/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..176b95fa8d307cca8dc1c2a4633a550d2d01198a --- /dev/null +++ b/243/history_text.txt @@ -0,0 +1 @@ +The patient has an externally histologically confirmed squamous cell carcinoma of the left edge of the tongue. On palpation, this extends up to the midline. The floor of the mouth and the base of the tongue are not infiltrated. Due to the large extension in the area of the tongue body, there is an indication for resection with possible defect reconstruction. The surgical procedure was discussed in detail with the patient and her family. A panendoscopy performed in domo showed no other suspicious lesions in the area of the upper aerodigestive tract. \ No newline at end of file diff --git a/243/icd_codes.txt b/243/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3c240b330d89440dd5d87dcce35ef5abf9bec189 --- /dev/null +++ b/243/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Zunge mehrere Teilbereiche überlappend[C02.8 L] \ No newline at end of file diff --git a/243/ops_codes.txt b/243/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f51655f6965bed0506c8ae411b35b7829df7e205 --- /dev/null +++ b/243/ops_codes.txt @@ -0,0 +1 @@ +Temporäre Tracheotomie[5-311.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Transorale Hemiglossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Entnahme myokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.23 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 R] \ No newline at end of file diff --git a/243/patient_clinical_data.json b/243/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f5004fdaa62a15a0153da15378be53d24fd7d549 --- /dev/null +++ b/243/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 71, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/243/patient_pathological_data.json b/243/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..32795d19780c8ce1719ff995d82f512741f6f134 --- /dev/null +++ b/243/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "243", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 21, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.6", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/243/surgery_description.txt b/243/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d6bfd4964ea7a0ca3017fe670d0013fe029d491 --- /dev/null +++ b/243/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheotomy, Defect coverage diff --git a/243/surgery_report.txt b/243/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c6396410b42d7460be512cfd17793b2e9561cfb4 --- /dev/null +++ b/243/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater. Introductory consultation with the anesthesia colleagues and induction of intubation anesthesia by the colleagues. After anesthesia has been administered, the surgeon positions the patient's head. First, the flexible gastroesophagoscopy is performed in the usual manner. This reveals the presence of an axial hiatal hernia. Despite a positive diaphanoscopy, a PEG tube is not inserted in consultation with . The nasogastric tube is inserted. The right arm is then repositioned, the surgical field is wiped sterile after injection of Suprarenin cervically on both sides in the area of the skin incision. Sterile wiping and draping of the patient. Start of the operation by performing a protective tracheostomy. To do this, make an incision just below the cricoid cartilage over 1.5 cm. Cut through the cutaneous-subcutaneous tissue. Identification of the infrahyoid musculature. Identification of the thyroid isthmus. Sharp incision of the cricoid cartilage. Undermining the thyroid isthmus with the clamp. Performing isthmus splitting after extensive bipolar coagulation. Exposure of the anterior tracheal wall and incision in the 2nd to 3rd intertracheal space. A visor tracheotomy is inserted and epithelialized in the usual manner using sutures. The patient is then reintubated and enoral tumor resection begins after insertion of the mouth retractor. Snare the tongue and begin tumor resection with the harmonic knife from anterior to posterior. A palpatory distance of approx. 1 cm from the tumor is maintained. During dissection, a branch of the lingual artery is exposed in depth. This can be safely exposed and ligated. After removal of the tumor specimen, it is placed on a cork plate and the anterior, posterior, lateral and medial resectate margins are marked. Basally, the specimen is marked short long anterior basally and long long posterior basally. The specimen is sent for frozen section diagnostics. After receiving the histology, a narrow resection margin of 0.4 cm is seen basally anteriorly. A new piece is then removed from the anterior basal wound bed and also sent for final histopathological assessment, this time marked with a suture. After subtle hemostasis using bipolar coagulation forceps, the radialis graft is lifted from the right arm by and . Palpatory identification of the distal radial artery. Marking of the flap borders (4.5 x 7.5 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to protect the ulnar artery. Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vascular clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Identification of the distal radial artery and trial clamping with a vascular clip. After 5 minutes under good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation. Visualization of the brachial artery, V. mediana cubiti, A. ulnaris. First the radial artery is removed, then two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Neck dissection is first performed on the left side. Here, regions I - IV are removed while sparing all non-lyphatic structures, including the gl. submandibularis. The superior thyroid artery and the facial artery are then dissected for subsequent anastomosis. Now also similar neck dissection on the right. Here, region Ia and Ib are also completely removed, but the submandibular artery is only mobilized as far as necessary and then refixed in its old position. After removal of the radialis graft, the graft is pulled through the defect tunnel. Insertion of the graft in the specified location and suturing using several single button sutures in the usual manner. Anastomosis of the radial artery to the superior thyroid artery and of 2 veins in an end-to-side manner to the internal jugular vein. At the end, subtle hemostasis using bipolar coagulation forceps. The neck is now dry. Wound closure using cutaneous and subcutaneous sutures in the usual manner after insertion of a flap. \ No newline at end of file diff --git a/244/InvasionFront_CD3_block4_x1_y11_patient244_0.json b/244/InvasionFront_CD3_block4_x1_y11_patient244_0.json new file mode 100644 index 0000000000000000000000000000000000000000..816ef9bb81e6788a2354cc4c24a128a5639c7878 --- /dev/null +++ b/244/InvasionFront_CD3_block4_x1_y11_patient244_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 33132.5, + "Num Detections": 25621, + "Num Negative": 25439, + "Num Positive": 182, + "Positive %": 0.7104, + "Num Positive per mm^2": 71.63 + } +} \ No newline at end of file diff --git a/244/InvasionFront_CD3_block4_x2_y11_patient244_1.json b/244/InvasionFront_CD3_block4_x2_y11_patient244_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7368e9ff34e3d3e7f9360b4ee1ed10043f78230c --- /dev/null +++ b/244/InvasionFront_CD3_block4_x2_y11_patient244_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8720.4, + "Centroid Y µm": 33232.4, + "Num Detections": 22276, + "Num Negative": 21860, + "Num Positive": 416, + "Positive %": 1.867, + "Num Positive per mm^2": 196.41 + } +} \ No newline at end of file diff --git a/244/InvasionFront_CD8_block4_x1_y11_patient244_0.json b/244/InvasionFront_CD8_block4_x1_y11_patient244_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a1659ad555139569dd7c894c9a4a7af6614df420 --- /dev/null +++ b/244/InvasionFront_CD8_block4_x1_y11_patient244_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 32457.8, + "Num Detections": 25984, + "Num Negative": 25829, + "Num Positive": 155, + "Positive %": 0.5965, + "Num Positive per mm^2": 59.12 + } +} \ No newline at end of file diff --git a/244/InvasionFront_CD8_block4_x2_y11_patient244_1.json b/244/InvasionFront_CD8_block4_x2_y11_patient244_1.json new file mode 100644 index 0000000000000000000000000000000000000000..010c7cf0fea18b040e8757eb38fae32db940e38e --- /dev/null +++ b/244/InvasionFront_CD8_block4_x2_y11_patient244_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 32532.8, + "Num Detections": 20865, + "Num Negative": 20696, + "Num Positive": 169, + "Positive %": 0.81, + "Num Positive per mm^2": 77.43 + } +} \ No newline at end of file diff --git a/244/TumorCenter_CD3_block4_x1_y11_patient244_0.json b/244/TumorCenter_CD3_block4_x1_y11_patient244_0.json new file mode 100644 index 0000000000000000000000000000000000000000..26055ed7831016501fb53036ecaa21db0de493cf --- /dev/null +++ b/244/TumorCenter_CD3_block4_x1_y11_patient244_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 28434.9, + "Num Detections": 24113, + "Num Negative": 21666, + "Num Positive": 2447, + "Positive %": 10.15, + "Num Positive per mm^2": 984.24 + } +} \ No newline at end of file diff --git a/244/TumorCenter_CD3_block4_x2_y11_patient244_1.json b/244/TumorCenter_CD3_block4_x2_y11_patient244_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9cf50a97d17f5ef70288465091cc15d22c5fb12d --- /dev/null +++ b/244/TumorCenter_CD3_block4_x2_y11_patient244_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 28335.0, + "Num Detections": 26088, + "Num Negative": 25429, + "Num Positive": 659, + "Positive %": 2.526, + "Num Positive per mm^2": 267.72 + } +} \ No newline at end of file diff --git a/244/TumorCenter_CD8_block4_x1_y11_patient244_0.json b/244/TumorCenter_CD8_block4_x1_y11_patient244_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3c7f8e95b4bda32654655b51b7547602b6c997e1 --- /dev/null +++ b/244/TumorCenter_CD8_block4_x1_y11_patient244_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3498.1, + "Centroid Y µm": 27985.2, + "Num Detections": 25057, + "Num Negative": 23362, + "Num Positive": 1695, + "Positive %": 6.765, + "Num Positive per mm^2": 672.17 + } +} \ No newline at end of file diff --git a/244/TumorCenter_CD8_block4_x2_y11_patient244_1.json b/244/TumorCenter_CD8_block4_x2_y11_patient244_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d66af1983706241811c32b82a4a75ffb1d064778 --- /dev/null +++ b/244/TumorCenter_CD8_block4_x2_y11_patient244_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 27985.2, + "Num Detections": 27439, + "Num Negative": 27110, + "Num Positive": 329, + "Positive %": 1.199, + "Num Positive per mm^2": 130.71 + } +} \ No newline at end of file diff --git a/244/history_text.txt b/244/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/244/icd_codes.txt b/244/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/244/ops_codes.txt b/244/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/244/patient_clinical_data.json b/244/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..efc062f1b971f6ff93f9fd33f559c8e54333b439 --- /dev/null +++ b/244/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 46, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 37, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/244/patient_pathological_data.json b/244/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b88f671f1dd5a936dc579c37dad4d56862f85d10 --- /dev/null +++ b/244/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "244", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/244/surgery_description.txt b/244/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7ee4d8e6ec19df737d6cefcca8626b5a060b463f --- /dev/null +++ b/244/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngectomy, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/244/surgery_report.txt b/244/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/245/InvasionFront_CD3_block14_x3_y6_patient245_0.json b/245/InvasionFront_CD3_block14_x3_y6_patient245_0.json new file mode 100644 index 0000000000000000000000000000000000000000..256d2c4c63229ae74927680cc93629ea078f6388 --- /dev/null +++ b/245/InvasionFront_CD3_block14_x3_y6_patient245_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11793.8, + "Centroid Y µm": 18790.1, + "Num Detections": 17983, + "Num Negative": 17742, + "Num Positive": 241, + "Positive %": 1.34, + "Num Positive per mm^2": 97.03 + } +} \ No newline at end of file diff --git a/245/InvasionFront_CD3_block14_x4_y6_patient245_1.json b/245/InvasionFront_CD3_block14_x4_y6_patient245_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c52344708d966353cc3604783d5834d9534a6afc --- /dev/null +++ b/245/InvasionFront_CD3_block14_x4_y6_patient245_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14567.3, + "Centroid Y µm": 18915.0, + "Num Detections": 16246, + "Num Negative": 15944, + "Num Positive": 302, + "Positive %": 1.859, + "Num Positive per mm^2": 127.24 + } +} \ No newline at end of file diff --git a/245/InvasionFront_CD8_block14_x3_y6_patient245_0.json b/245/InvasionFront_CD8_block14_x3_y6_patient245_0.json new file mode 100644 index 0000000000000000000000000000000000000000..211b74d4c906d73910f9b33a72f37abbfa06d28b --- /dev/null +++ b/245/InvasionFront_CD8_block14_x3_y6_patient245_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11893.7, + "Centroid Y µm": 14667.2, + "Num Detections": 20873, + "Num Negative": 20733, + "Num Positive": 140, + "Positive %": 0.6707, + "Num Positive per mm^2": 57.93 + } +} \ No newline at end of file diff --git a/245/InvasionFront_CD8_block14_x4_y6_patient245_1.json b/245/InvasionFront_CD8_block14_x4_y6_patient245_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1bca8561e1d60046febb3bdb41376f9cf9fd8854 --- /dev/null +++ b/245/InvasionFront_CD8_block14_x4_y6_patient245_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14492.3, + "Centroid Y µm": 14667.2, + "Num Detections": 18656, + "Num Negative": 18240, + "Num Positive": 416, + "Positive %": 2.23, + "Num Positive per mm^2": 171.3 + } +} \ No newline at end of file diff --git a/245/TumorCenter_CD3_block14_x3_y6_patient245_0.json b/245/TumorCenter_CD3_block14_x3_y6_patient245_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6ca58886fb01b866f283d7e0c12606ca41de5d14 --- /dev/null +++ b/245/TumorCenter_CD3_block14_x3_y6_patient245_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11618.8, + "Centroid Y µm": 15416.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/245/TumorCenter_CD3_block14_x4_y6_patient245_1.json b/245/TumorCenter_CD3_block14_x4_y6_patient245_1.json new file mode 100644 index 0000000000000000000000000000000000000000..53d141dc1a0f8d1a8bdced9f6563b9a49bbdc42a --- /dev/null +++ b/245/TumorCenter_CD3_block14_x4_y6_patient245_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14192.5, + "Centroid Y µm": 15591.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/245/TumorCenter_CD8_block14_x3_y6_patient245_0.json b/245/TumorCenter_CD8_block14_x3_y6_patient245_0.json new file mode 100644 index 0000000000000000000000000000000000000000..223df3d481ed837e6224883ce80b693a1b2e8ec7 --- /dev/null +++ b/245/TumorCenter_CD8_block14_x3_y6_patient245_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10719.3, + "Centroid Y µm": 15566.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/245/TumorCenter_CD8_block14_x4_y6_patient245_1.json b/245/TumorCenter_CD8_block14_x4_y6_patient245_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cc5e7d5db612162e8031f0292acdec4ae942965a --- /dev/null +++ b/245/TumorCenter_CD8_block14_x4_y6_patient245_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13218.0, + "Centroid Y µm": 15591.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/245/history_text.txt b/245/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..70ac194877b8e3b7a0d9c87b7120da6af1bf6ed9 --- /dev/null +++ b/245/history_text.txt @@ -0,0 +1 @@ +The patient has had a whitish, partly dolent change on the left edge of her tongue for several months. A sample was taken alio loco, which revealed a G2 squamous cell carcinoma. CT imaging of the primary was not conclusive due to dental artifacts. Sonography showed a cN0 neck status. The patient was informed in detail about the procedure and had sufficient time to ask questions. \ No newline at end of file diff --git a/245/icd_codes.txt b/245/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4a2f7556ec2c83f0f91a482f743fe830c025e195 --- /dev/null +++ b/245/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrücken[C02.0 ] Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/245/ops_codes.txt b/245/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..37dce7a1459226ef934c8d021c4cf39bc76f8c86 --- /dev/null +++ b/245/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/245/patient_clinical_data.json b/245/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..be3dc71c9ca5249c18cf113511b6e0c03b96fc07 --- /dev/null +++ b/245/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 45, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/245/patient_pathological_data.json b/245/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..85046c1a049d347fedfd1ee68c1acc6e7544f1e3 --- /dev/null +++ b/245/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "245", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.5 +} \ No newline at end of file diff --git a/245/surgery_description.txt b/245/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c67ba6f0d23102082084b48f7a1864a4cc274ae --- /dev/null +++ b/245/surgery_description.txt @@ -0,0 +1 @@ +Resection and Panendoscopy diff --git a/245/surgery_report.txt b/245/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..30141b1f76e9582b3a3203c5cd2792fb40897f8d --- /dev/null +++ b/245/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesiology colleagues, first rigid tracheoscopy. The trachea is free of irritation up to the tracheal bifurcation. Subsequently intubation by the anesthesia colleagues and transition to flexible esophagoscopy. Under constant air insufgflation, pre-scopy up to the stomach, the mucosa is free of irritation even with inversion, no ulcer, no bleeding. Then aspirate the air from the stomach and carefully mirror back. No abnormalities in the esophagus. Subsequent low head position and mircolaryngoscopy. The vocal folds and anterior commissure are smooth and without irritation, as are the arytenoid cartilage and postcricoid region. The piriform sinus and vallecula are freely unfoldable, no mass. Tonsils and base of trachea also without irritation and free to palpate. Subsequent addition of . Snaring of the tongue and insertion of a covered mouth guard. A whitish mucosa with extensions and palpatory hardening, approx. 2x0.5 cm in size, is visible on the left edge of the tongue in the posterior third. The mucosa appears to be easily displaceable against the muscle. The area was then resected with an electric needle, suture marking at ant/post and superior. The mass was completely removed by palpation and inspection. The specimen is thread-marked and sent for frozen section examination. This revealed higher grade dysplastic cells in the superior margin up to 0.1 cm from the resection margin, which is why a further resection was performed here, which was then sent for final histology. Subsequent meticulous hemostasis using bipolar coagulation and adaptive sutures with Vicryl 4-0. Removal of the mouth retractor, removal of the tongue loop, dental status as preoperative. Conclusion: the patient underwent an excision biopsy for cT1 cN0 tongue margin carcinoma with alio loco confirmed squamous cell carcinoma at the left tongue margin. The frozen section resulted in a complete resection; in the case of higher grade dysplasia in the superior margin, a further resection was performed. Please note final histology and presentation TuKo. \ No newline at end of file diff --git a/246/InvasionFront_CD3_block10_x1_y1_patient246_0.json b/246/InvasionFront_CD3_block10_x1_y1_patient246_0.json new file mode 100644 index 0000000000000000000000000000000000000000..addcb39a5e8582753723991e8e968cf0bbc82ba0 --- /dev/null +++ b/246/InvasionFront_CD3_block10_x1_y1_patient246_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7071.3, + "Centroid Y µm": 7670.9, + "Num Detections": 26275, + "Num Negative": 25964, + "Num Positive": 311, + "Positive %": 1.184, + "Num Positive per mm^2": 117.65 + } +} \ No newline at end of file diff --git a/246/InvasionFront_CD3_block10_x2_y1_patient246_1.json b/246/InvasionFront_CD3_block10_x2_y1_patient246_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c09226078b1213ada826388160e4f602a3d344e --- /dev/null +++ b/246/InvasionFront_CD3_block10_x2_y1_patient246_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9495.0, + "Centroid Y µm": 7845.8, + "Num Detections": 22396, + "Num Negative": 21446, + "Num Positive": 950, + "Positive %": 4.242, + "Num Positive per mm^2": 377.31 + } +} \ No newline at end of file diff --git a/246/InvasionFront_CD8_block10_x1_y1_patient246_0.json b/246/InvasionFront_CD8_block10_x1_y1_patient246_0.json new file mode 100644 index 0000000000000000000000000000000000000000..20fe04d19b0bbcde2c9427d01a746a96e4e17808 --- /dev/null +++ b/246/InvasionFront_CD8_block10_x1_y1_patient246_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5722.0, + "Centroid Y µm": 7546.0, + "Num Detections": 26164, + "Num Negative": 25816, + "Num Positive": 348, + "Positive %": 1.33, + "Num Positive per mm^2": 134.83 + } +} \ No newline at end of file diff --git a/246/InvasionFront_CD8_block10_x2_y1_patient246_1.json b/246/InvasionFront_CD8_block10_x2_y1_patient246_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f5bd102f77f7f3baecd97e2570af07ac73b6316 --- /dev/null +++ b/246/InvasionFront_CD8_block10_x2_y1_patient246_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8270.6, + "Centroid Y µm": 7845.8, + "Num Detections": 23271, + "Num Negative": 22639, + "Num Positive": 632, + "Positive %": 2.716, + "Num Positive per mm^2": 255.46 + } +} \ No newline at end of file diff --git a/246/TumorCenter_CD3_block10_x1_y1_patient246_0.json b/246/TumorCenter_CD3_block10_x1_y1_patient246_0.json new file mode 100644 index 0000000000000000000000000000000000000000..69878bdbebf948d0f797195a228737b3ffa37993 --- /dev/null +++ b/246/TumorCenter_CD3_block10_x1_y1_patient246_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 2898.5, + "Num Detections": 23673, + "Num Negative": 20901, + "Num Positive": 2772, + "Positive %": 11.71, + "Num Positive per mm^2": 1118.2 + } +} \ No newline at end of file diff --git a/246/TumorCenter_CD3_block10_x2_y1_patient246_1.json b/246/TumorCenter_CD3_block10_x2_y1_patient246_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fba2300e5b4f77520ee4d2308f11c86d27bbb0e1 --- /dev/null +++ b/246/TumorCenter_CD3_block10_x2_y1_patient246_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8745.4, + "Centroid Y µm": 2798.5, + "Num Detections": 24071, + "Num Negative": 22063, + "Num Positive": 2008, + "Positive %": 8.342, + "Num Positive per mm^2": 770.94 + } +} \ No newline at end of file diff --git a/246/TumorCenter_CD8_block10_x1_y1_patient246_0.json b/246/TumorCenter_CD8_block10_x1_y1_patient246_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ab0ed42334a0eed1aca0676e2449d8033bc136b --- /dev/null +++ b/246/TumorCenter_CD8_block10_x1_y1_patient246_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 2998.4, + "Centroid Y µm": 3997.9, + "Num Detections": 22922, + "Num Negative": 18254, + "Num Positive": 4668, + "Positive %": 20.36, + "Num Positive per mm^2": 1863.9 + } +} \ No newline at end of file diff --git a/246/TumorCenter_CD8_block10_x2_y1_patient246_1.json b/246/TumorCenter_CD8_block10_x2_y1_patient246_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f76c7d580a42b0cee14b67336af7ff0019f56982 --- /dev/null +++ b/246/TumorCenter_CD8_block10_x2_y1_patient246_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5322.2, + "Centroid Y µm": 3498.1, + "Num Detections": 23305, + "Num Negative": 20247, + "Num Positive": 3058, + "Positive %": 13.12, + "Num Positive per mm^2": 1196.1 + } +} \ No newline at end of file diff --git a/246/history_text.txt b/246/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..eaea58c216beb274fe6098f2e911298853c8c996 --- /dev/null +++ b/246/history_text.txt @@ -0,0 +1 @@ +The patient had a T2 tonsillar carcinoma of the left tonsil region, which left the tonsil in the upper part of the tonsil and spread to the anterior palatal arch. Due to the number and shape of conspicuous lymph nodes on both sides of the neck, which were described on CT, the indication for tumor removal and neck dissection on both sides was given in advance. \ No newline at end of file diff --git a/246/icd_codes.txt b/246/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/246/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/246/ops_codes.txt b/246/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6ae330e77dc03f43f06fa25eb87deb7c5e6ead1d --- /dev/null +++ b/246/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Pharyngoplastik mit lokaler Schleimhaut[5-293.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] \ No newline at end of file diff --git a/246/patient_clinical_data.json b/246/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c536d5b495bc1abf19dd27411b5f2caeb21c52b1 --- /dev/null +++ b/246/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 40, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/246/patient_pathological_data.json b/246/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0365a2778d3d829fe6c53c01c7aff328d144eea8 --- /dev/null +++ b/246/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "246", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/246/surgery_description.txt b/246/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..76cfdacc34357af123c1655bfb6ffc4d132a38fd --- /dev/null +++ b/246/surgery_description.txt @@ -0,0 +1 @@ +Transoral robot-assisted tumor removal, Neck dissection diff --git a/246/surgery_report.txt b/246/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7c28ddf3c99a892d9e6e7529452ec7389fd38a54 --- /dev/null +++ b/246/surgery_report.txt @@ -0,0 +1 @@ +First, the patient is positioned and another panendoscopy is performed to confirm the findings. The findings are essentially unchanged compared to the previous examination, with the tumor extending as described above. Otherwise no indication of a secondary tumor. Then insertion of the Olympus oral retractor and adjustment of the tonsil lodge. Then insertion and positioning of the robotic arms. Use a monopolar spatula and Maryland forceps. Then expose the tumor. With a sufficient safety margin, start the resection on the anterior soft palate parauvularly. The resection is then performed along the posterior molar to the base of the tongue via the glossotonsillar groove. As the tumor cannot be reliably separated from the base of the tongue here, a small part of the base of the tongue is resected. The tumor is then developed and a partial resection of the posterior palatal arch is performed. The dissection is performed in such a way that a soft tissue margin remains on the tonsil capsule. There is no evidence of tumor infiltration in the area of the lateral tonsil capsule. After complete removal, the specimen is then thread-marked and sent for histopathological assessment. In the area of the scarce resections at the glossotonsillar groove and at the base of the tongue, additional marginal samples are taken, which are assessed as tumor-free in the frozen section. After tumor removal, the most subtle hemostasis is performed. Then absolutely dry wound conditions. Then removal of the oral retractor and removal of the surgical instruments. The patient is then repositioned for neck dissection on both sides. Injection of local anesthetic with adrenaline on both sides of the neck. Then start the neck dissection on the left side via a skin incision along the front edge of the sternocleidomastoid muscle. Then layer-by-layer dissection in depth after cutting through the platysma, exposing the anterior edge of the muscle. Then expose the cervical vascular sheath. Now dissect along and expose the cervical vascular sheath. A large conglomerate of lymph nodes can be seen in the area of the venous angle. The lymph nodes also appear clinically conspicuous here. Then dissection of level Ib while preserving the branches of the external carotid artery and the internal jugular artery. The capsule of the submandibular gland is not removed during dissection. Subsequently, further dissection of levels II, III, IV and V. Numerous lymph nodes already extend caudally along the cervical vascular sheath, so that the dissection is also carried out far caudally. When the specimen is placed in the caudal section, an opening of the thoracic duct can be seen, with fluid leaking out here. This area is then sutured over with a small amount of sternocleidomastoid muscle and the entire region carefully stitched over. Even when the intrathoracic pressure was raised via a peep by the colleagues in the anesthesia department, there was no further leakage of chyle. Subsequent subtle hemostasis and insertion of a Redon drain. Then two-layer wound closure. Now move to the right side. Here too, skin incision along the sternocleidomastoid muscle. Then layer-by-layer dissection in depth. Cut through the platysma, then expose the anterior edge of the sternocleidomastoid muscle and the cervical vascular sheath. Subsequently, a clearly smaller conglomerate can be seen at the lymph node in the venous angle. Then evacuation of level Ib, sparing the branches of the external carotid artery and internal jugular artery. Level II and III were also removed. After no further suspicious nodes are found in the caudal region, which are also not described on CT, and the tumor is nowhere near the midline, no further clearing of levels IV and V is performed. Subtle hemostasis is then performed and a Redon drain is then inserted. Here too, subsequent two-layer wound closure. After bandaging, the procedure is completed and the patient is transferred to the recovery room after extubation. \ No newline at end of file diff --git a/247/InvasionFront_CD3_block14_x1_y2_patient247_0.json b/247/InvasionFront_CD3_block14_x1_y2_patient247_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9a1cc9bcbf23145e3822bc6cb983df53a5168c2d --- /dev/null +++ b/247/InvasionFront_CD3_block14_x1_y2_patient247_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5097.3, + "Centroid Y µm": 8595.4, + "Num Detections": 19137, + "Num Negative": 17737, + "Num Positive": 1400, + "Positive %": 7.316, + "Num Positive per mm^2": 558.61 + } +} \ No newline at end of file diff --git a/247/InvasionFront_CD3_block14_x2_y2_patient247_1.json b/247/InvasionFront_CD3_block14_x2_y2_patient247_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1645df03ed8e5018741163f06036e7bc0f0ca2bf --- /dev/null +++ b/247/InvasionFront_CD3_block14_x2_y2_patient247_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7720.9, + "Centroid Y µm": 8695.4, + "Num Detections": 17462, + "Num Negative": 15647, + "Num Positive": 1815, + "Positive %": 10.39, + "Num Positive per mm^2": 744.66 + } +} \ No newline at end of file diff --git a/247/InvasionFront_CD8_block14_x1_y2_patient247_0.json b/247/InvasionFront_CD8_block14_x1_y2_patient247_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a6be72c2723434194902037ac3a046266457386 --- /dev/null +++ b/247/InvasionFront_CD8_block14_x1_y2_patient247_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5147.3, + "Centroid Y µm": 5022.3, + "Num Detections": 16746, + "Num Negative": 14721, + "Num Positive": 2025, + "Positive %": 12.09, + "Num Positive per mm^2": 851.33 + } +} \ No newline at end of file diff --git a/247/InvasionFront_CD8_block14_x2_y2_patient247_1.json b/247/InvasionFront_CD8_block14_x2_y2_patient247_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2d18c05633c23765bdb8c449502b6fceca96f296 --- /dev/null +++ b/247/InvasionFront_CD8_block14_x2_y2_patient247_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7670.9, + "Centroid Y µm": 5072.3, + "Num Detections": 16862, + "Num Negative": 11394, + "Num Positive": 5468, + "Positive %": 32.43, + "Num Positive per mm^2": 2333.1 + } +} \ No newline at end of file diff --git a/247/TumorCenter_CD3_block14_x1_y2_patient247_0.json b/247/TumorCenter_CD3_block14_x1_y2_patient247_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a0fcd4f36f9aac6b6f1347ce65fa90f4c5c837bb --- /dev/null +++ b/247/TumorCenter_CD3_block14_x1_y2_patient247_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5047.3, + "Centroid Y µm": 4972.4, + "Num Detections": 16723, + "Num Negative": 14836, + "Num Positive": 1887, + "Positive %": 11.28, + "Num Positive per mm^2": 777.83 + } +} \ No newline at end of file diff --git a/247/TumorCenter_CD3_block14_x2_y2_patient247_1.json b/247/TumorCenter_CD3_block14_x2_y2_patient247_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bfb3e0a8abe6b1cdd328a6ea1b0fc9084aa8af31 --- /dev/null +++ b/247/TumorCenter_CD3_block14_x2_y2_patient247_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7596.0, + "Centroid Y µm": 5172.3, + "Num Detections": 12438, + "Num Negative": 11483, + "Num Positive": 955, + "Positive %": 7.678, + "Num Positive per mm^2": 393.83 + } +} \ No newline at end of file diff --git a/247/TumorCenter_CD8_block14_x1_y2_patient247_0.json b/247/TumorCenter_CD8_block14_x1_y2_patient247_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1a609cb242b036bb68b63738cabfb6ff198815ae --- /dev/null +++ b/247/TumorCenter_CD8_block14_x1_y2_patient247_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.1, + "Centroid Y µm": 5747.0, + "Num Detections": 17454, + "Num Negative": 14563, + "Num Positive": 2891, + "Positive %": 16.56, + "Num Positive per mm^2": 1179.0 + } +} \ No newline at end of file diff --git a/247/TumorCenter_CD8_block14_x2_y2_patient247_1.json b/247/TumorCenter_CD8_block14_x2_y2_patient247_1.json new file mode 100644 index 0000000000000000000000000000000000000000..390d1c47e93135f42bdc0523d1e39375433a948f --- /dev/null +++ b/247/TumorCenter_CD8_block14_x2_y2_patient247_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 5771.9, + "Num Detections": 18143, + "Num Negative": 16510, + "Num Positive": 1633, + "Positive %": 9.001, + "Num Positive per mm^2": 668.07 + } +} \ No newline at end of file diff --git a/247/history_text.txt b/247/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e166f6b9b4aa391fb02d1309379caa26198a0714 --- /dev/null +++ b/247/history_text.txt @@ -0,0 +1 @@ +Unclear new lingual mass on the right side. As part of an external biopsy, at least carcinoma in situ. There is now an indication for panendoscopy and excision of the mass in toto. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/247/icd_codes.txt b/247/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ff2082a0115c5d5aa669e34936cf7d1a67d017e9 --- /dev/null +++ b/247/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 R] \ No newline at end of file diff --git a/247/ops_codes.txt b/247/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..19544cc7e15e66e570bb4cd63ea2bac45f4d818f --- /dev/null +++ b/247/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/247/patient_clinical_data.json b/247/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f2921b6c3ff489c473c461038c370306500fffaa --- /dev/null +++ b/247/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/247/patient_pathological_data.json b/247/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..86a4287df53b03cadafc18dbd58f06bef87e8a84 --- /dev/null +++ b/247/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "247", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": null, + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/247/surgery_description.txt b/247/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c67ba6f0d23102082084b48f7a1864a4cc274ae --- /dev/null +++ b/247/surgery_description.txt @@ -0,0 +1 @@ +Resection and Panendoscopy diff --git a/247/surgery_report.txt b/247/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c2a936cc6bbfa0a471b996e2fbaa746cd78c4f6 --- /dev/null +++ b/247/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesiologist. Induction of anesthesia and transition to rigid tracheoscopy. Problem-free passage of the non-irritated glottis and entry after endotracheal. Mucosal conditions are unremarkable on all sides up to the exit of the segmental bronchi. Withdrawal of the endoscope and intubation of the patient by the surgeon. Fixation of the tube. Transition to esophagogastroscopy. Insertion of the flexible endoscope under visualization and constant air insufflation into the stomach. With the exception of isolated polyps, the gastric mucosa is otherwise free of irritation. Inversion and inspection of the gastroesophageal junction. This also appears unremarkable. After desufflation, slow withdrawal of the endoscope with circular inspection of all sections of the esophagus. Inconspicuous conditions on all sides. Remove the endoscope. Proceed to hypopharyngoscopy and laryngoscopy. First insert the mouth guard. Position the patient in head reclination. Enter with the size C small bore tube and initially adjust the endolarynx. This appears unremarkable. Then inspect the piriform sinus on both sides. This is lined on both sides with smooth, non-irritant mucosa and can be freely unfolded up to the tip. The same applies to the postcricoid region and the esophageal entrance. Inspection of the vallecula and the base of the tongue. Inconspicuous conditions here too. Subsequently, removal of the small drainage tube and insertion of the reinforced retractor. Inspection of the oral cavity and the oral vestibule. An exophytic, highly visible mass can be seen in the area of the dorsum of the tongue at the transition to the right edge of the tongue. Mark the planned resection margins. The tumor is then cut around using the electric needle and scissors. Hemostasis using bipolar coagulation. The definitive lateral and medial margin samples are then taken and sent for definitive histological processing. Hemostasis using bipolar coagulation. Injection of ropivacaine for postoperative analgesia. Repeated hemostasis using bipolar coagulation. Adaptation of the wound edges using inverting sutures with PDS 4-0. The mucosa in the area of the remaining oral cavity and the oral vestibule is free of irritation on all sides. Final consultation with the anesthetist. Removal of the mouth blocker and completion of the operation without complications. Note: The gastric polyps should also be assessed gastroenterologically at intervals. \ No newline at end of file diff --git a/248/InvasionFront_CD3_block19_x3_y11_patient248_0.json b/248/InvasionFront_CD3_block19_x3_y11_patient248_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8e058c6532c4cf6e95a3037fc3aa9280237db49b --- /dev/null +++ b/248/InvasionFront_CD3_block19_x3_y11_patient248_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 29509.4, + "Num Detections": 19379, + "Num Negative": 18637, + "Num Positive": 742, + "Positive %": 3.829, + "Num Positive per mm^2": 306.51 + } +} \ No newline at end of file diff --git a/248/InvasionFront_CD3_block19_x4_y11_patient248_1.json b/248/InvasionFront_CD3_block19_x4_y11_patient248_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f0e2a73078d1a2893d533fc8bd54dcbb4af632a0 --- /dev/null +++ b/248/InvasionFront_CD3_block19_x4_y11_patient248_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 29659.3, + "Num Detections": 16083, + "Num Negative": 15794, + "Num Positive": 289, + "Positive %": 1.797, + "Num Positive per mm^2": 126.24 + } +} \ No newline at end of file diff --git a/248/InvasionFront_CD8_block19_x3_y11_patient248_0.json b/248/InvasionFront_CD8_block19_x3_y11_patient248_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad356141ec310f103c67c08857c8cb1f672ca0d3 --- /dev/null +++ b/248/InvasionFront_CD8_block19_x3_y11_patient248_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 37205.3, + "Num Detections": 29038, + "Num Negative": 28604, + "Num Positive": 434, + "Positive %": 1.495, + "Num Positive per mm^2": 158.25 + } +} \ No newline at end of file diff --git a/248/InvasionFront_CD8_block19_x4_y11_patient248_1.json b/248/InvasionFront_CD8_block19_x4_y11_patient248_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc95a02951cd8c9a151d87e2e0ebe9e1130f78b5 --- /dev/null +++ b/248/InvasionFront_CD8_block19_x4_y11_patient248_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 37355.2, + "Num Detections": 26453, + "Num Negative": 26199, + "Num Positive": 254, + "Positive %": 0.9602, + "Num Positive per mm^2": 96.38 + } +} \ No newline at end of file diff --git a/248/TumorCenter_CD3_block19_x3_y11_patient248_0.json b/248/TumorCenter_CD3_block19_x3_y11_patient248_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cf043b98fbcee6dd68dbeeac6aa8daf37e5f6f04 --- /dev/null +++ b/248/TumorCenter_CD3_block19_x3_y11_patient248_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13564.0, + "Centroid Y µm": 28420.1, + "Num Detections": 16249, + "Num Negative": 13125, + "Num Positive": 3124, + "Positive %": 19.23, + "Num Positive per mm^2": 1156.7 + } +} \ No newline at end of file diff --git a/248/TumorCenter_CD3_block19_x4_y11_patient248_1.json b/248/TumorCenter_CD3_block19_x4_y11_patient248_1.json new file mode 100644 index 0000000000000000000000000000000000000000..205bdb6bfac1b19deb1778a46dd23ffb94bb9526 --- /dev/null +++ b/248/TumorCenter_CD3_block19_x4_y11_patient248_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16088.5, + "Centroid Y µm": 28133.7, + "Num Detections": 17317, + "Num Negative": 16471, + "Num Positive": 846, + "Positive %": 4.885, + "Num Positive per mm^2": 311.22 + } +} \ No newline at end of file diff --git a/248/TumorCenter_CD8_block19_x3_y11_patient248_0.json b/248/TumorCenter_CD8_block19_x3_y11_patient248_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c0f462c40dd413a32064a99a19a1fbad11bb5481 --- /dev/null +++ b/248/TumorCenter_CD8_block19_x3_y11_patient248_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 38704.5, + "Num Detections": 30647, + "Num Negative": 27530, + "Num Positive": 3117, + "Positive %": 10.17, + "Num Positive per mm^2": 1073.0 + } +} \ No newline at end of file diff --git a/248/TumorCenter_CD8_block19_x4_y11_patient248_1.json b/248/TumorCenter_CD8_block19_x4_y11_patient248_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6613cbcd29cc30bd7cdcfa80cb034ba65967e688 --- /dev/null +++ b/248/TumorCenter_CD8_block19_x4_y11_patient248_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 38754.5, + "Num Detections": 29919, + "Num Negative": 29678, + "Num Positive": 241, + "Positive %": 0.8055, + "Num Positive per mm^2": 83.96 + } +} \ No newline at end of file diff --git a/248/history_text.txt b/248/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..dc97dd63140d0285cc03f705db7fa46a650af226 --- /dev/null +++ b/248/history_text.txt @@ -0,0 +1 @@ +The patient had an incidental finding of a mass in the aryepiglottic fold on the right side. After sampling, a G3, non-keratinizing squamous cell carcinoma was found, hence the indication for the above-mentioned procedure. \ No newline at end of file diff --git a/248/icd_codes.txt b/248/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7af9d48e72358f0d6d1087f5348fc77085d2054 --- /dev/null +++ b/248/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 R] \ No newline at end of file diff --git a/248/ops_codes.txt b/248/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..80d5351da90a6e6375c40d5340782b249a2061a2 --- /dev/null +++ b/248/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Endoskopische Laserresektion am Larynx[5-302.5 ] Selektive Neck dissection in 4 Regionen[5-403.03 R] \ No newline at end of file diff --git a/248/patient_clinical_data.json b/248/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..defec3f3cf33b5b74f1128ab5694f11374b67479 --- /dev/null +++ b/248/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/248/patient_pathological_data.json b/248/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..19e4abcad22f83b998d7553437396609d23d0598 --- /dev/null +++ b/248/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "248", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/248/surgery_description.txt b/248/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..671c1c12d3747daeb0f1d9452a5724f874f2fa7d --- /dev/null +++ b/248/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection, Neck dissection, and Tracheotomy diff --git a/248/surgery_report.txt b/248/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f28cb3507310015fc37318f2c588f384caae00ee --- /dev/null +++ b/248/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia by the anesthesiologist, intubation using a laser tube, followed by entry with a small bore tube and inspection of the hypopharynx and larynx. An exophytic mass is seen in the area of the aryepiglottic fold on the right and at the piriform sinus entrance on the right. The mass is filmed. Then attempt to insert a spreading laryngoscope. This is particularly difficult. Call in , who is able to adjust the tumor with difficulty. Perform laser resection, starting on the medial side. Successive resection of the tumor with a safety margin so that the tumor is safely removed from the healthy tissue. Removal of several marginal samples. All R0 in the frozen section. At the end, insertion of supratupers and hemostasis using monopolar coagulation. No bleeding. Glottis not affected and free, therefore no tracheostomy performed and no PEG inserted. Sterile washing and draping for neck dissection on the right side. After consultation with , in the case of cN0 and small tumor extension, only neck dissection on the right side. Incision of a skin fold for this. Dissection of the platysma. Dissection of the platysma cranially. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland. Exposure of the cervical vascular sheath. Dissection of the internal jugular vein. Dissection of the facial vein. Exposure of the hypoglossal nerve. Exposure of the accessorius nerve. Dissection of the plexus branches II a to IV and dissection of the neck levels II a to IV, while sparing the plexus branches. The neck levels are sent in individually. The patient is a study patient in the study. Please present urgently at the tumor conference. If adjuvant therapy is necessary, this must be carried out in . \ No newline at end of file diff --git a/249/InvasionFront_CD3_block12_x3_y7_patient249_0.json b/249/InvasionFront_CD3_block12_x3_y7_patient249_0.json new file mode 100644 index 0000000000000000000000000000000000000000..644e6855ad2370cc0a14f0f206b0ec18f2ed337e --- /dev/null +++ b/249/InvasionFront_CD3_block12_x3_y7_patient249_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11294.0, + "Centroid Y µm": 22263.2, + "Num Detections": 17521, + "Num Negative": 17495, + "Num Positive": 26, + "Positive %": 0.1484, + "Num Positive per mm^2": 11.83 + } +} \ No newline at end of file diff --git a/249/InvasionFront_CD3_block12_x4_y7_patient249_1.json b/249/InvasionFront_CD3_block12_x4_y7_patient249_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69cff02aea2a38069b6790dfdbceb2e2fed2f13d --- /dev/null +++ b/249/InvasionFront_CD3_block12_x4_y7_patient249_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 22488.1, + "Num Detections": 15476, + "Num Negative": 15272, + "Num Positive": 204, + "Positive %": 1.318, + "Num Positive per mm^2": 105.02 + } +} \ No newline at end of file diff --git a/249/InvasionFront_CD8_block12_x3_y7_patient249_0.json b/249/InvasionFront_CD8_block12_x3_y7_patient249_0.json new file mode 100644 index 0000000000000000000000000000000000000000..31f46200c3c4c349737a46b97900fa4e9984b498 --- /dev/null +++ b/249/InvasionFront_CD8_block12_x3_y7_patient249_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12343.5, + "Centroid Y µm": 21388.7, + "Num Detections": 19048, + "Num Negative": 18915, + "Num Positive": 133, + "Positive %": 0.6982, + "Num Positive per mm^2": 58.66 + } +} \ No newline at end of file diff --git a/249/InvasionFront_CD8_block12_x4_y7_patient249_1.json b/249/InvasionFront_CD8_block12_x4_y7_patient249_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f88528b4e3767da1a12ab18ccf7d91e150dabdb0 --- /dev/null +++ b/249/InvasionFront_CD8_block12_x4_y7_patient249_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14892.1, + "Centroid Y µm": 21338.7, + "Num Detections": 15825, + "Num Negative": 15689, + "Num Positive": 136, + "Positive %": 0.8594, + "Num Positive per mm^2": 69.76 + } +} \ No newline at end of file diff --git a/249/TumorCenter_CD3_block12_x3_y7_patient249_0.json b/249/TumorCenter_CD3_block12_x3_y7_patient249_0.json new file mode 100644 index 0000000000000000000000000000000000000000..847d8e042855fa7dc9255d327b8c07ceb7b6bb74 --- /dev/null +++ b/249/TumorCenter_CD3_block12_x3_y7_patient249_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10694.3, + "Centroid Y µm": 17440.8, + "Num Detections": 20506, + "Num Negative": 19907, + "Num Positive": 599, + "Positive %": 2.921, + "Num Positive per mm^2": 254.65 + } +} \ No newline at end of file diff --git a/249/TumorCenter_CD3_block12_x4_y7_patient249_1.json b/249/TumorCenter_CD3_block12_x4_y7_patient249_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5ea208b65742472dc230d6a58e5f6b9fad41828b --- /dev/null +++ b/249/TumorCenter_CD3_block12_x4_y7_patient249_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 17515.7, + "Num Detections": 18522, + "Num Negative": 18211, + "Num Positive": 311, + "Positive %": 1.679, + "Num Positive per mm^2": 142.44 + } +} \ No newline at end of file diff --git a/249/TumorCenter_CD8_block12_x3_y7_patient249_0.json b/249/TumorCenter_CD8_block12_x3_y7_patient249_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ffdda250cb0dee4d8d3cab0dfead273eca831be --- /dev/null +++ b/249/TumorCenter_CD8_block12_x3_y7_patient249_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 26735.8, + "Num Detections": 18252, + "Num Negative": 18052, + "Num Positive": 200, + "Positive %": 1.096, + "Num Positive per mm^2": 87.43 + } +} \ No newline at end of file diff --git a/249/TumorCenter_CD8_block12_x4_y7_patient249_1.json b/249/TumorCenter_CD8_block12_x4_y7_patient249_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ea61593a596e6aba539561b8f81c7804ac6d6a57 --- /dev/null +++ b/249/TumorCenter_CD8_block12_x4_y7_patient249_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 26860.8, + "Num Detections": 17213, + "Num Negative": 17078, + "Num Positive": 135, + "Positive %": 0.7843, + "Num Positive per mm^2": 67.6 + } +} \ No newline at end of file diff --git a/249/history_text.txt b/249/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..33a4866221287da79dd4675916ef8e8425652e0c --- /dev/null +++ b/249/history_text.txt @@ -0,0 +1 @@ +cT3 cNx oropharyngeal carcinoma right; cT1a vocal fold carcinoma right; atheroma of the nasal root median. \ No newline at end of file diff --git a/249/icd_codes.txt b/249/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2222e08fdb48bcc9eb62a1fcf9dc41ea94d226c6 --- /dev/null +++ b/249/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/249/ops_codes.txt b/249/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9e1e81e94cfad30f00cf0970442192c59bef5b23 --- /dev/null +++ b/249/ops_codes.txt @@ -0,0 +1 @@ +Pharyngoplastik mit mikrovaskulär anastomosiertem Transplantat[5-293.2 ] Selektive Neck dissection in fünf Regionen[5-403.04 B] Exzision und Destruktion von erkranktem Gewebe des Larynx: Dekortikation einer Stimmlippe, mikrolaryngoskopisch[5-300.5 ] Andere Exzision von (erkrankten) Blutgefäßen und Transplantatentnahme: Arterien Unterarm und Hand: A. radialis[5-386.24 L] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Genitalregion[5-895.4c ] Permanente Tracheotomie[5-312.0 ] Sonstige Exzision und Destruktion erkranktes Gewebe Nase[5-212.x ] Klinische Untersuchung in Allgemeinanästhesie[1-100 ] \ No newline at end of file diff --git a/249/patient_clinical_data.json b/249/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..209ba3ad49316ca5a0a2e39e34eff949910fefd5 --- /dev/null +++ b/249/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 47, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/249/patient_pathological_data.json b/249/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c7449d0d2e2ffe63cce40ca2f9e5530eb9cc900c --- /dev/null +++ b/249/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "249", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/249/surgery_description.txt b/249/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..abf0103dd5932f4f7bebd947526a7334c125eb08 --- /dev/null +++ b/249/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Modified radical bilateral neck dissection, Defect coverage, Free flap (Radial), Laser resection of StiLi (Supraglottic and Infraglottic) carcinoma, Tracheostomy, PEG placement, Panendoscopy diff --git a/249/surgery_report.txt b/249/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..514c7d4193ad142c5ef81347e40b663eb7b86a8b --- /dev/null +++ b/249/surgery_report.txt @@ -0,0 +1 @@ +First, after induction of anesthesia, renewed panendoscopy: The tonsillar carcinoma on the right, as described above, was found to be over 4 cm in size, extending to the hard palate and the mandible. Decision to perform transoral tumor resection. Recheck of the vocal fold findings: Here the findings are rather inconspicuous. Based on the histology, decision to perform laser resection. Initial PEG placement 9 Charričre: insertion of the flexible esophagogastroscope. Inspection of the gastric mucosa and oesophagus and then placement of the gastric tube under strict diaphanoscopic control. Fixation of the holding plates and repositioning for laser resection: Here, the tumor is excised relatively superficially from dorsal to anterior after power with 5 watts and continuous mode of . 2 anterior and dorsal margin samples are sent for frozen section histology. Here, dysplasia is still found in the dorsal part, and a new microlaryngoscopic ablation is performed in the dorsal part, well within the normal healthy area, for final histological assessment. Hemostasis with a supratip. If the wound is inconspicuous, repositioning for modified radical neck dissection on the right side: curved skin incision. Exposure of the anterior edge of the sternocleidomastoid after cutting through the platysma. No ligation of the external jugular vein, but lateral displacement to reduce lymphoedema. Exposure of the internal jugular vein. Now from caudal to cranial mobilization of the sternocleidomastoid. Locate the accessor nerve, which is found, dissected further cranially and spared in the further course of the operation. Establish the upper resection margin at the belly of the digaster muscle, which is followed ventrally. Now lateral to the internal jugular vein, place the caudal neck preparation in the area of region IV. No conspicuous lymph nodes here and from caudal to cranial, after exposing the vagus nerve and phrenic nerve on the scalenus muscles, consecutive development of the lateral neck preparation up to the accessorius triangle. Detachment of the same along the digastric muscle. Dissection of the submandibular gland, which is then deposited at the whartonian duct. The facial artery and facial vein are selectively dissected and spared. In the depth of the submandibular region (region Ib), removal of a conspicuous lymph node without capsular perforation. Careful hemostasis and dissection of the carotid bifurcation, especially the thyroid artery for subsequent vascularization. Now complete the ventral neck preparation and repeat hemostasis. Irrigation with H2O and repositioning for neck dissection on the left side: also here skin incision and dissection of the sternocleidomastoid muscle and, while preserving the accessorius nerve, the jugular vein, exposure of the hypoglossal nerve and here a modified radical neck dissection of levels II, III, IV and V is performed. Here too, meticulous hemostasis and completion of the procedure on the left side of the neck. Now horizontal skin incision for tracheotomy. Cut through the subcutaneous tissue to the infralaryngeal musculature, blunt, partly sharp cutting of the same and mobilization of the thyroid isthmus. This is undermined, grasped with 2 clamps and treated with a tobacco pouch suture after transection. The tracheal lumen is now opened between the 2nd and 3rd tracheal clasp. Formation of a Björk flap and transfer to a Rügheim cannula. Further ventilation is problem-free. Fixation of the cannula to the skin of the neck with 2 retaining threads. Now repositioning for tumor resection: After setting the tonsil stop, the tumor is now resected far into the healthy tissue with the electric knife, in some cases also sharply with the .................................... coagulation, initially from the anterior and posterior palatal arch, the cheek region is partly included and thus the tumor is resected far into the macroscopically healthy tissue. The tumor is detached from the hard palate with the freer, also from the mandible and traced further caudally into the depth of the lateral pharyngeal wall. Resection of the inner mandibular corticalis, which is sent with the tumor specimen. Now develop the entire tumor specimen transcervically and carefully stop the bleeding. Now take representative marginal samples from all 4 quadrants, which are found to be tumor-free in the frozen section assessment. Now reposition for radial artery flap harvesting: After abjuring and sterile draping, make an S-shaped incision from the antecubital region to the distal. Preparation of a skin graft corresponding to the defect and preservation of the same after preparation of a broad-lumen arterial connection and a venous drainage route. Inguinal skin harvesting: Spindle-shaped, adapted detachment of a full-thickness skin graft in the right inguinal region. Meticulous hemostasis and under slight tension, the primary wound closure is quite successful. A Redon drain is inserted beforehand. After irrigation with ............ solution of the graft, the forearm graft is subtly sutured into the defect. The superior thyroid artery is now dissected caudally transcervically and anastomosed to the arterial segment of the forearm flap. The venous segment is now connected with continuous suturing after selective ligation of several branches. There is very good perfusion without leakage. Intraoral control of the connected flap shows stable perfusion after pressure. In the meantime, long-term medication with the heparin perfusor is also started. Defect coverage of the forearm defect with the inguinal skin graft. Wound closure on both cervical sides after insertion of an 8-gauge Redon drain. After checking again that there is no bleeding in the flap area and perfusion, repositioning to remove a nasal atheroma: spindle-shaped skin incision with a skin spindle. Dissection of the subcutaneous tissue and removal of the atheroma in toto. Meticulous hemostasis using the above-mentioned skin spindle. In the absence of bleeding in the surgical area, wound closure with 5/0 Ethilon suture. Completion of the procedure after fixation of the tracheostoma on the cannula ligament. Check all drains. Patient is intubated and ventilated until morden in the intensive care unit. The patient received 250 mg SDH intraoperatively and intravenous antibiotics with Unacid 3 g were started. \ No newline at end of file diff --git a/250/InvasionFront_CD3_block1_x3_y9_patient250_0.json b/250/InvasionFront_CD3_block1_x3_y9_patient250_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0c1dba68b9484555942be70def469748d52ee14a --- /dev/null +++ b/250/InvasionFront_CD3_block1_x3_y9_patient250_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11062.5, + "Centroid Y µm": 24232.3, + "Num Detections": 14665, + "Num Negative": 14623, + "Num Positive": 42, + "Positive %": 0.2864, + "Num Positive per mm^2": 23.24 + } +} \ No newline at end of file diff --git a/250/InvasionFront_CD3_block1_x4_y9_patient250_1.json b/250/InvasionFront_CD3_block1_x4_y9_patient250_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6661e745911754628d77ecf74d380384b875ad4f --- /dev/null +++ b/250/InvasionFront_CD3_block1_x4_y9_patient250_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 24287.1, + "Num Detections": 14680, + "Num Negative": 14601, + "Num Positive": 79, + "Positive %": 0.5381, + "Num Positive per mm^2": 43.92 + } +} \ No newline at end of file diff --git a/250/InvasionFront_CD8_block1_x3_y9_patient250_0.json b/250/InvasionFront_CD8_block1_x3_y9_patient250_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b569dac98fa250d4e13864eda105e3e319f0cbd9 --- /dev/null +++ b/250/InvasionFront_CD8_block1_x3_y9_patient250_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11161.1, + "Centroid Y µm": 22723.8, + "Num Detections": 13210, + "Num Negative": 13200, + "Num Positive": 10, + "Positive %": 0.0757, + "Num Positive per mm^2": 6.031 + } +} \ No newline at end of file diff --git a/250/InvasionFront_CD8_block1_x4_y9_patient250_1.json b/250/InvasionFront_CD8_block1_x4_y9_patient250_1.json new file mode 100644 index 0000000000000000000000000000000000000000..533d8260cd131e55e99f1847d5312346c174ed97 --- /dev/null +++ b/250/InvasionFront_CD8_block1_x4_y9_patient250_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13693.0, + "Centroid Y µm": 22815.9, + "Num Detections": 11664, + "Num Negative": 11642, + "Num Positive": 22, + "Positive %": 0.1886, + "Num Positive per mm^2": 13.31 + } +} \ No newline at end of file diff --git a/250/TumorCenter_CD3_block1_x3_y11_patient250_0.json b/250/TumorCenter_CD3_block1_x3_y11_patient250_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f431286d9701f694a02dad0441b9c3bb6b6be505 --- /dev/null +++ b/250/TumorCenter_CD3_block1_x3_y11_patient250_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 27410.5, + "Num Detections": 20487, + "Num Negative": 8404, + "Num Positive": 12083, + "Positive %": 58.98, + "Num Positive per mm^2": 5186.5 + } +} \ No newline at end of file diff --git a/250/TumorCenter_CD3_block1_x4_y11_patient250_1.json b/250/TumorCenter_CD3_block1_x4_y11_patient250_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c75f0e4b3bfb8803d5802a7e84ac57b873592868 --- /dev/null +++ b/250/TumorCenter_CD3_block1_x4_y11_patient250_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 27260.6, + "Num Detections": 21739, + "Num Negative": 10928, + "Num Positive": 10811, + "Positive %": 49.73, + "Num Positive per mm^2": 4467.6 + } +} \ No newline at end of file diff --git a/250/TumorCenter_CD8_block1_x3_y9_patient250_0.json b/250/TumorCenter_CD8_block1_x3_y9_patient250_0.json new file mode 100644 index 0000000000000000000000000000000000000000..76ee4ceae270340865e97539485eea85a46cdc53 --- /dev/null +++ b/250/TumorCenter_CD8_block1_x3_y9_patient250_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 31283.4, + "Num Detections": 18533, + "Num Negative": 18532, + "Num Positive": 1, + "Positive %": 0.0054, + "Num Positive per mm^2": 0.5159 + } +} \ No newline at end of file diff --git a/250/TumorCenter_CD8_block1_x4_y9_patient250_1.json b/250/TumorCenter_CD8_block1_x4_y9_patient250_1.json new file mode 100644 index 0000000000000000000000000000000000000000..316cc98732bc42602196c3fc1bec6d4aee15e71b --- /dev/null +++ b/250/TumorCenter_CD8_block1_x4_y9_patient250_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 31258.4, + "Num Detections": 17660, + "Num Negative": 17639, + "Num Positive": 21, + "Positive %": 0.1189, + "Num Positive per mm^2": 10.48 + } +} \ No newline at end of file diff --git a/250/history_text.txt b/250/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/250/icd_codes.txt b/250/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a9fbea0fb97b412fa2bb67eab7eb9a2e3e3cc2ae --- /dev/null +++ b/250/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des weichen Gaumens[C05.1 ] Wangenschleimhautkarzinom[C06.0 ] Neubildung bösartig Gaumenbogen (vorderer) (hinterer)[C09.1 ] \ No newline at end of file diff --git a/250/ops_codes.txt b/250/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9022521aa918b6b9b374e813d72af34c2f3f69c4 --- /dev/null +++ b/250/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Destruktion: Elektrokoagulation[5-292.30 ] Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Entnahme freier Radialis-Lappen[5-858.23 R] Deckung mit freiem Radialis-Lappen Unterarm[5-858.73 R] Vollhaut großflächig Empfängerstelle Leisten- und Genitalregion[5-902.6c ] Anlage anderer Shunt und Bypass sonstige Blutgefäße[5-393.x R] Wechsel vaskuläres Implantat[5-394.3 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 B] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/250/patient_clinical_data.json b/250/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7d085811fb529c0dad1e249224960d5c3fcba909 --- /dev/null +++ b/250/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/250/patient_pathological_data.json b/250/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9427cd530295661ee5122e2aec5e046e844eaa97 --- /dev/null +++ b/250/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "250", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/250/surgery_description.txt b/250/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ff585e3e6cc868bc3913e51e5d7f66fac5a81ab4 --- /dev/null +++ b/250/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Bilateral neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/250/surgery_report.txt b/250/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa7b7882ba5e10c1a2d5b12fc4a0a699d65fead7 --- /dev/null +++ b/250/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and nasotracheal intubation by the anesthesiologist, a new pharyngoscopy is performed: a 4 cm large, exophytic mass is seen, which starts paramedian on the right side of the soft palate, completely affects the anterior palatal arch, extends over the retromolar region towards the cheek, is cranially approx. 5 mm from the alveolar ridge of the maxilla and infiltrates caudally via the glossotonsillar groove approx. 5 mm into the base of the tongue. Now insert the tonsil retractor and resect the mass with the electric needle. With a safety distance of approximately 1 cm. Deep dissection up to the medial pterygoid muscle and leaving a minimal layer of the posterior palatal arch. After cranial resection directly at the posterior edge of the alveolar ridge of the maxilla and also resection in the area of the cheek with a clear distance from the stenon's duct. As the mass is firmly attached to the posterior alveolar ridge of the mandible and also appears to infiltrate into the depths, it is dissected there with a safe distance to the periosteum of the mandible and from there the periosteum is pushed away from the bone with the Raspa. At one point, the tumor appears to have attacked the cortical bone. The resection extends along the posterior floor of the mouth in the base of the tongue, here with an increased safety margin. The submandibular gland of the right side is exposed in depth and separated from the tumor preparation. After complete removal, the specimen is now marked with a thread (short/short = towards the uvula; short/long = towards the upper jaw; long/long = towards the base of the tongue and green thread along the lower jaw). On closer inspection, a small region between the lower jaw and the base of the tongue appears to be infiltrated right into the resection margin. Therefore, a resection is performed starting from the lower jaw along the floor of the mouth to the base of the tongue. Both preparations are sent for frozen section examination. The subsequent result shows that one site of the main preparation was indeed not healthy, but the corresponding resection no longer shows a tumor, so that a local R0 resection is present. An additional frozen section examination of the wound bed was performed, which was also tumor-free. Now insertion of a hydrogen swab and turning to neck dissection. First modified radical neck dissection type III left, level Ib to V: Curved skin incision along the anterior edge of the sternocleidomastoid. Dissection through subcutaneous tissue and platysma. Exposure and sparing of the external jugular vein. Identification of the vagus nerve, the omohyoid muscle and the posterior digaster venter muscle. An approx. 4 cm large metastasis is seen in the area of the venous angle, which makes the entire dissection difficult. Dissection of the internal jugular vein, which can be easily separated from the tumor mass. A facial vein is not found in the typical location, but much further caudally. This is now dissected from caudal to cranial, can be dissected for about 5 cm, but must then be separated due to very close contact with the tumor conglomerate. After identification of the hypoglossal nerve and skeletonization of the submandibular gland from the caudal side, the tumour conglomerate is separated from the carotid artery and sent for final histology. At the same time, the superior thyroid artery can be visualized well. Now turn to the lateral neck preparation. Expose the vagus nerve and the scalene muscles and dissect around level IIb caudally while sparing the plexus branches. Now turn to selective neck dissection of the left side, levels II to IV: Similarly curved skin incision along the sternocleidomastoid anterior edge. Dissection through the subcutaneous tissue and platysma. Long dissection and sparing of the external jugular vein and the auricular nerve. Identification of the accessorius nerve, the omohyoid muscle and the posterior digaster venter muscle. Dissection along the internal jugular vein while sparing the cervical vein. First form and remove the medial neck preparation after identifying the hypoglossal nerve and the superior thyroid artery and then form the lateral neck preparation from cranial to caudal while protecting the plexus branches. Now turn to the tracheotomy: Approx. 2 1/2 cm long, horizontal incision over the cricoid cartilage. Dissection through subcutaneous tissue, identification and spreading of the prelaryngeal musculature. Exposure of the cricoid cartilage. Directly caudal to it, the first tracheal ring on the right side appears fractured and scarred. Exposure of a very small thyroid isthmus and bipolation of the same. Now expose the anterior tracheal wall, which shows normal anatomy again caudal to the first tracheal ring. Horizontal incision into the trachea between the 2nd and 3rd tracheal ring and formation of a small Björk flap. Epithelialization of the flap using tracheostomy sutures. Re-intubation on a .................. tube. Further surgery is now dictated by . Continuation . Transoral resection of a right oral cavity oropharyngeal carcinoma cT2 to 3, modified radical neck dissection on both sides, tracheostoma placement, defect coverage in the oral cavity, oropharynx and tongue base area using a microvascular pedicled radial flap from the right, defect coverage on the right forearm using full-thickness skin from the left groin (, i. Alternation, assistance: ) Lifting of the radialis flap initially from the subfascial radial side. In doing so, protection of the nerve.......................... The radial artery is exposed and clamped. Continue the operation under pulse oximeter observation. Elevation of the radialis flap now also subfascially from the ulna, incision is continued along the forearm along the brachioradialis muscle up to the crook of the elbow in a curved shape. Inclusion of the cephalic vein in the flap as a superficial drainage system. Subcutaneous tissue is still included cranial to the skin island. Flap pedicle is exposed up to the crook of the elbow. No changes in saturation on the finger after approx. 45 min. This always remained at 100%, even after clamping the radial artery. The radial artery is therefore now disconnected and supplied caudally and cranially by means of a puncture ligature. Successive elevation of the flap along the course of the pedicle and treatment of smaller vascular branches with clips. The flap pedicle contains the superficial and deep venous system as well as the radial artery. The radial artery is dissected up to the olecranon and removed before the outlet of the interosseous artery and treated with a puncture ligature. The venous outflow is removed after the confluence of the superficial and deep venous system in the area of the cephalic vein. The vein is ligated. Flap is removed and flushed with heparin. The vascular pedicle was already freed from adventitia during dissection. Subsequent insertion of the flap into the oral cavity oropharyngeal defect: First cut through the digastric muscle from the neck side. A tunnel, 2 transverse fingers wide submandibularly, is then created as a passage for the pedicle. The flap is then inserted into the defect and the pedicle is passed through the tunnel. Successive suturing of the flap into the enoral defect using single button Vicryl 3/0 sutures. Complete defect coverage without tension. The superior thyroid artery is then exposed, dissected, freed from the adventitia, cut and ligated distally. The proximal part is prepared with the arterial anastomosis and sutured with 8/0 Ethilon single-button sutures. After opening the clamp, strong pulse and strong venous return. The access of the facial vein to the internal jugular vein is chosen for the venous anastomosis. The flap pedicle is first sutured with infrahyoid muscles to prevent kinking. The vein size is measured. A coupler size 3/0 is selected. The veins are trimmed while they are anastomized with the coupler without tension. Gelitta is inserted to prevent kinking of the vascular pedicle. The wound is then carefully rinsed again and the blood is stopped. The wound is closed in layers with the insertion of a Redon drain. A tracheal cannula with a core is inserted and fixed with sutures. The vessels of the vascular pedicle were fixed to the neck skin area using markers and checked using Doppler sonography. The procedure was completed without complications. The patient is admitted to the intensive care unit for postoperative monitoring. Please continue the antibiotic treatment started with Unacid i.v. 3 x 1.5 g. Heparin perfusor with 500 E/h for 3 days in total. Please keep patient ventilated for one night. Regular checks of the vascular pedicle by ultrasound and clinically according to the scheme. Please feed patient via inserted PEG for 10 days, then gruel and, if necessary, build up diet. \ No newline at end of file diff --git a/251/InvasionFront_CD3_block8_x1_y5_patient251_2.json b/251/InvasionFront_CD3_block8_x1_y5_patient251_2.json new file mode 100644 index 0000000000000000000000000000000000000000..5c3b173c9361d82622ab45c7e44d86508e7f6416 --- /dev/null +++ b/251/InvasionFront_CD3_block8_x1_y5_patient251_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 22713.0, + "Num Detections": 23543, + "Num Negative": 21325, + "Num Positive": 2218, + "Positive %": 9.421, + "Num Positive per mm^2": 842.45 + } +} \ No newline at end of file diff --git a/251/InvasionFront_CD3_block8_x2_y5_patient251_3.json b/251/InvasionFront_CD3_block8_x2_y5_patient251_3.json new file mode 100644 index 0000000000000000000000000000000000000000..92f02b2865e3a743867f37318131707af4abe156 --- /dev/null +++ b/251/InvasionFront_CD3_block8_x2_y5_patient251_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6171.7, + "Centroid Y µm": 22663.0, + "Num Detections": 20214, + "Num Negative": 19799, + "Num Positive": 415, + "Positive %": 2.053, + "Num Positive per mm^2": 197.28 + } +} \ No newline at end of file diff --git a/251/InvasionFront_CD3_block8_x5_y4_patient251_0.json b/251/InvasionFront_CD3_block8_x5_y4_patient251_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5941d8131a672530d6728c6047f7e1a4f24de3e1 --- /dev/null +++ b/251/InvasionFront_CD3_block8_x5_y4_patient251_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 20264.3, + "Num Detections": 22798, + "Num Negative": 20616, + "Num Positive": 2182, + "Positive %": 9.571, + "Num Positive per mm^2": 921.92 + } +} \ No newline at end of file diff --git a/251/InvasionFront_CD3_block8_x6_y4_patient251_1.json b/251/InvasionFront_CD3_block8_x6_y4_patient251_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8caa6d98e128c94142880c9436b72919f638afd5 --- /dev/null +++ b/251/InvasionFront_CD3_block8_x6_y4_patient251_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 20189.3, + "Num Detections": 21006, + "Num Negative": 18514, + "Num Positive": 2492, + "Positive %": 11.86, + "Num Positive per mm^2": 1086.4 + } +} \ No newline at end of file diff --git a/251/InvasionFront_CD8_block8_x1_y5_patient251_2.json b/251/InvasionFront_CD8_block8_x1_y5_patient251_2.json new file mode 100644 index 0000000000000000000000000000000000000000..e70962dbdfbc8f931cf9ad1104a1badcf5314980 --- /dev/null +++ b/251/InvasionFront_CD8_block8_x1_y5_patient251_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4447.6, + "Centroid Y µm": 12143.6, + "Num Detections": 23827, + "Num Negative": 22341, + "Num Positive": 1486, + "Positive %": 6.237, + "Num Positive per mm^2": 567.42 + } +} \ No newline at end of file diff --git a/251/InvasionFront_CD8_block8_x2_y5_patient251_3.json b/251/InvasionFront_CD8_block8_x2_y5_patient251_3.json new file mode 100644 index 0000000000000000000000000000000000000000..f1649391ec0a75a9d8c4a9f51985397bf56554d9 --- /dev/null +++ b/251/InvasionFront_CD8_block8_x2_y5_patient251_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6896.3, + "Centroid Y µm": 12368.5, + "Num Detections": 21967, + "Num Negative": 21677, + "Num Positive": 290, + "Positive %": 1.32, + "Num Positive per mm^2": 128.18 + } +} \ No newline at end of file diff --git a/251/InvasionFront_CD8_block8_x5_y4_patient251_0.json b/251/InvasionFront_CD8_block8_x5_y4_patient251_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0557b49d1283f19517d6b56f28b3c954dad2523f --- /dev/null +++ b/251/InvasionFront_CD8_block8_x5_y4_patient251_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17091.0, + "Centroid Y µm": 10569.4, + "Num Detections": 23423, + "Num Negative": 20224, + "Num Positive": 3199, + "Positive %": 13.66, + "Num Positive per mm^2": 1355.1 + } +} \ No newline at end of file diff --git a/251/InvasionFront_CD8_block8_x6_y4_patient251_1.json b/251/InvasionFront_CD8_block8_x6_y4_patient251_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a612e3ef094667f59b892651a36921251b784875 --- /dev/null +++ b/251/InvasionFront_CD8_block8_x6_y4_patient251_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19639.6, + "Centroid Y µm": 10719.3, + "Num Detections": 21993, + "Num Negative": 19103, + "Num Positive": 2890, + "Positive %": 13.14, + "Num Positive per mm^2": 1248.8 + } +} \ No newline at end of file diff --git a/251/TumorCenter_CD3_block8_x1_y5_patient251_2.json b/251/TumorCenter_CD3_block8_x1_y5_patient251_2.json new file mode 100644 index 0000000000000000000000000000000000000000..8e77050ecf01cdc3385d0b431f2189675beac07f --- /dev/null +++ b/251/TumorCenter_CD3_block8_x1_y5_patient251_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4522.6, + "Centroid Y µm": 14242.5, + "Num Detections": 18205, + "Num Negative": 16606, + "Num Positive": 1599, + "Positive %": 8.783, + "Num Positive per mm^2": 707.62 + } +} \ No newline at end of file diff --git a/251/TumorCenter_CD3_block8_x2_y5_patient251_3.json b/251/TumorCenter_CD3_block8_x2_y5_patient251_3.json new file mode 100644 index 0000000000000000000000000000000000000000..272bee007bfa49f92e8a3892047b5404efa6787d --- /dev/null +++ b/251/TumorCenter_CD3_block8_x2_y5_patient251_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6871.4, + "Centroid Y µm": 13942.6, + "Num Detections": 22553, + "Num Negative": 19207, + "Num Positive": 3346, + "Positive %": 14.84, + "Num Positive per mm^2": 1363.6 + } +} \ No newline at end of file diff --git a/251/TumorCenter_CD3_block8_x5_y4_patient251_0.json b/251/TumorCenter_CD3_block8_x5_y4_patient251_0.json new file mode 100644 index 0000000000000000000000000000000000000000..de7b47109d70bf3c7ae55a7dd5b8052545f1d29e --- /dev/null +++ b/251/TumorCenter_CD3_block8_x5_y4_patient251_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 10469.5, + "Num Detections": 23682, + "Num Negative": 22205, + "Num Positive": 1477, + "Positive %": 6.237, + "Num Positive per mm^2": 620.56 + } +} \ No newline at end of file diff --git a/251/TumorCenter_CD3_block8_x6_y4_patient251_1.json b/251/TumorCenter_CD3_block8_x6_y4_patient251_1.json new file mode 100644 index 0000000000000000000000000000000000000000..38a7a212256278b572d6fb107ba481507a345b52 --- /dev/null +++ b/251/TumorCenter_CD3_block8_x6_y4_patient251_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 10169.6, + "Num Detections": 21898, + "Num Negative": 20271, + "Num Positive": 1627, + "Positive %": 7.43, + "Num Positive per mm^2": 694.97 + } +} \ No newline at end of file diff --git a/251/TumorCenter_CD8_block8_x1_y5_patient251_2.json b/251/TumorCenter_CD8_block8_x1_y5_patient251_2.json new file mode 100644 index 0000000000000000000000000000000000000000..d62b2d3f7bfe2fa1b0d898252a0b4c49cff966a7 --- /dev/null +++ b/251/TumorCenter_CD8_block8_x1_y5_patient251_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4147.8, + "Centroid Y µm": 13592.8, + "Num Detections": 21428, + "Num Negative": 20997, + "Num Positive": 431, + "Positive %": 2.011, + "Num Positive per mm^2": 192.0 + } +} \ No newline at end of file diff --git a/251/TumorCenter_CD8_block8_x2_y5_patient251_3.json b/251/TumorCenter_CD8_block8_x2_y5_patient251_3.json new file mode 100644 index 0000000000000000000000000000000000000000..037ac1f3c256f9a3257cea355c8c90689450f888 --- /dev/null +++ b/251/TumorCenter_CD8_block8_x2_y5_patient251_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6646.5, + "Centroid Y µm": 13392.9, + "Num Detections": 24404, + "Num Negative": 23955, + "Num Positive": 449, + "Positive %": 1.84, + "Num Positive per mm^2": 178.95 + } +} \ No newline at end of file diff --git a/251/TumorCenter_CD8_block8_x5_y4_patient251_0.json b/251/TumorCenter_CD8_block8_x5_y4_patient251_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2bfe197c236d8664120aa15620c163c9a1e49add --- /dev/null +++ b/251/TumorCenter_CD8_block8_x5_y4_patient251_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 10344.5, + "Num Detections": 22080, + "Num Negative": 20962, + "Num Positive": 1118, + "Positive %": 5.063, + "Num Positive per mm^2": 527.98 + } +} \ No newline at end of file diff --git a/251/TumorCenter_CD8_block8_x6_y4_patient251_1.json b/251/TumorCenter_CD8_block8_x6_y4_patient251_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0920172d2c1c45a9c3d64aa85155a33fba60ffcf --- /dev/null +++ b/251/TumorCenter_CD8_block8_x6_y4_patient251_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 10144.6, + "Num Detections": 22969, + "Num Negative": 21999, + "Num Positive": 970, + "Positive %": 4.223, + "Num Positive per mm^2": 413.83 + } +} \ No newline at end of file diff --git a/251/history_text.txt b/251/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/251/icd_codes.txt b/251/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc41ddf34d983856bdace53ad2c6977a41460b49 --- /dev/null +++ b/251/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/251/ops_codes.txt b/251/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..305c2e44125ed85cecd71aabea420d914c4588f3 --- /dev/null +++ b/251/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument[1-620.1 ] Diagnostische Tracheobronchoskopie mit starrem Instrument[1-620.1 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Temporäre Tracheotomie[5-311.0 ] Temporäre Tracheotomie[5-311.0 ] PEG-Sonde Anlage[5-431.2 ] PEG-Sonde Anlage[5-431.2 ] \ No newline at end of file diff --git a/251/patient_clinical_data.json b/251/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..55275ee42bb8efbf6f8eae06f530ddfecca2e98c --- /dev/null +++ b/251/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/251/patient_pathological_data.json b/251/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f52624b73ca606e094e2f6e35db8eff8a4d0e9a2 --- /dev/null +++ b/251/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "251", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/251/surgery_description.txt b/251/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b16db3ba749a21d77610d37968477d459ada957b --- /dev/null +++ b/251/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, PEG placement, Tracheostomy, Panendoscopy diff --git a/251/surgery_report.txt b/251/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d96506557b1ec245c5e54aca6cf308a6a17c9aa2 --- /dev/null +++ b/251/surgery_report.txt @@ -0,0 +1 @@ +After tracheoscopy during intubation, panendoscopy of the oropharynx and finally esophagoscopy were performed: Apart from the hypopharyngeal carcinoma on the left side described above, no other lesion was found. The tumor originates from the medial hypopharyngeal wall, just extending laterally onto the arytenoid hump, but neither affecting the interary region nor the postcricoid. Laterally, the tumor extends in the entrance of the piriform recess along the anterior wall and just reaches the lateral side wall. The tumor is quite easy to move with the suction cup, in particular there is mobility towards the arytenoid cusp on the left. A deep infiltration of the cusp does not appear to be present here. The vocal cords are also clinically mobile on both sides. A PEG tube is inserted as part of the final esophagoscopy. The left-sided hypopharyngeal tumor is then adjusted with the Steiner tube. Adjustability is good. The tumor is then completely ablated with the CO2 laser under microscopic vision. The safety margin is at least 0.5 cm. The tumor can be easily removed from the deep layers, especially from the arytenoid cusp, in healthy tissue. Nevertheless, a final resection is taken from the left arytenoid hump and sent for final histology. Careful hemostasis. This is followed by repositioning for neck dissection, first on the left: For this, skin incision in a skin fold, 2 to 3 transverse fingers submandibularly. After skin incision, dissection of the subcutaneous tissue and exposure of the platysmal flap. Creation of platysmal flaps caudally and cranially. Dissection of the anterior edge of the sternocleidomastoid to the vascular nerve sheath. Expose the posterior venter of the digastric muscle cranially. Dissection now along the omohyoid muscle from distal to proximal to the hyoid bone. Dissection of the lower edge of the submandibular gland and completion of the neck resectate to the hyoid bone. Dissection along the posterior digastric venter muscle to the base of the skull and subsequent dissection of the internal jugular vein. The dissection reveals numerous conspicuous lymph nodes. Level IIb and Va in particular show pronounced lymph node involvement. All vascular nerve structures were spared during the dissection. After elevation of regions II, III and IV, level 5 is completely elevated while sparing the plexus and the accessorius nerve. Subsequent neck dissection on the right side: The same procedure is used here with a corresponding skin incision 2 to 3 transverse fingers submandibularly. Creation of cranial and caudal platysmal flaps and dissection of the vascular nerve sheath by exposing the anterior edge of the sternocleidomastoid. Dissection along the omohyoid muscle up to the hyoid bone and along the posterior digastric venter muscle in the cranial region. Dissection along the internal jugular vein and also here elevation of the neck block in regions II, III and IV. Conspicuous nodes are found particularly in level IIb. Finally, also sparing the accessorius nerve and the cervical plexus, elevation of level V. Careful hemostasis on both sides. Insertion of 10 Redon drains on both sides, subcutaneous sutures and skin sutures on both sides. Sterile wound dressing. \ No newline at end of file diff --git a/252/InvasionFront_CD3_block5_x3_y1_patient252_0.json b/252/InvasionFront_CD3_block5_x3_y1_patient252_0.json new file mode 100644 index 0000000000000000000000000000000000000000..af1617a56007e597ad3591ba18073e23815d8805 --- /dev/null +++ b/252/InvasionFront_CD3_block5_x3_y1_patient252_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 2573.6, + "Num Detections": 21126, + "Num Negative": 19623, + "Num Positive": 1503, + "Positive %": 7.114, + "Num Positive per mm^2": 634.62 + } +} \ No newline at end of file diff --git a/252/InvasionFront_CD3_block5_x4_y1_patient252_1.json b/252/InvasionFront_CD3_block5_x4_y1_patient252_1.json new file mode 100644 index 0000000000000000000000000000000000000000..991d5ed04048a5b000cd27e542c08394042e5622 --- /dev/null +++ b/252/InvasionFront_CD3_block5_x4_y1_patient252_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 2398.7, + "Num Detections": 24244, + "Num Negative": 21708, + "Num Positive": 2536, + "Positive %": 10.46, + "Num Positive per mm^2": 1008.6 + } +} \ No newline at end of file diff --git a/252/InvasionFront_CD8_block5_x3_y1_patient252_0.json b/252/InvasionFront_CD8_block5_x3_y1_patient252_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e14379368d958f70cdb2438f494eb450270d0efa --- /dev/null +++ b/252/InvasionFront_CD8_block5_x3_y1_patient252_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 2923.5, + "Num Detections": 18549, + "Num Negative": 17103, + "Num Positive": 1446, + "Positive %": 7.796, + "Num Positive per mm^2": 663.83 + } +} \ No newline at end of file diff --git a/252/InvasionFront_CD8_block5_x4_y1_patient252_1.json b/252/InvasionFront_CD8_block5_x4_y1_patient252_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b3251e1a07a255570fcee3bef5441e2fb09e1383 --- /dev/null +++ b/252/InvasionFront_CD8_block5_x4_y1_patient252_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 2623.6, + "Num Detections": 22881, + "Num Negative": 20998, + "Num Positive": 1883, + "Positive %": 8.23, + "Num Positive per mm^2": 786.85 + } +} \ No newline at end of file diff --git a/252/TumorCenter_CD3_block5_x3_y1_patient252_0.json b/252/TumorCenter_CD3_block5_x3_y1_patient252_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2651ad6c11cf08025547427b673311263920aea1 --- /dev/null +++ b/252/TumorCenter_CD3_block5_x3_y1_patient252_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13317.9, + "Centroid Y µm": 2623.6, + "Num Detections": 19863, + "Num Negative": 17545, + "Num Positive": 2318, + "Positive %": 11.67, + "Num Positive per mm^2": 978.81 + } +} \ No newline at end of file diff --git a/252/TumorCenter_CD3_block5_x4_y1_patient252_1.json b/252/TumorCenter_CD3_block5_x4_y1_patient252_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65c681abf7d90cd13fa7118f8a5789005790d948 --- /dev/null +++ b/252/TumorCenter_CD3_block5_x4_y1_patient252_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15841.6, + "Centroid Y µm": 2823.5, + "Num Detections": 22458, + "Num Negative": 18614, + "Num Positive": 3844, + "Positive %": 17.12, + "Num Positive per mm^2": 1657.4 + } +} \ No newline at end of file diff --git a/252/TumorCenter_CD8_block5_x3_y1_patient252_0.json b/252/TumorCenter_CD8_block5_x3_y1_patient252_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9adff023b4ae82dd7ad02ae8798fb21b6f943e24 --- /dev/null +++ b/252/TumorCenter_CD8_block5_x3_y1_patient252_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11568.9, + "Centroid Y µm": 2548.7, + "Num Detections": 19932, + "Num Negative": 17490, + "Num Positive": 2442, + "Positive %": 12.25, + "Num Positive per mm^2": 986.82 + } +} \ No newline at end of file diff --git a/252/TumorCenter_CD8_block5_x4_y1_patient252_1.json b/252/TumorCenter_CD8_block5_x4_y1_patient252_1.json new file mode 100644 index 0000000000000000000000000000000000000000..60734b61df2aa2ac262a0628c12f7b8e2eadfbaf --- /dev/null +++ b/252/TumorCenter_CD8_block5_x4_y1_patient252_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14117.5, + "Centroid Y µm": 2573.6, + "Num Detections": 24383, + "Num Negative": 21133, + "Num Positive": 3250, + "Positive %": 13.33, + "Num Positive per mm^2": 1342.5 + } +} \ No newline at end of file diff --git a/252/history_text.txt b/252/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/252/icd_codes.txt b/252/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/252/ops_codes.txt b/252/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/252/patient_clinical_data.json b/252/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ddd546e1b0c01957c1d1164ee30ce224593a97ba --- /dev/null +++ b/252/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 60, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/252/patient_pathological_data.json b/252/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..70e422b0b45078bf0efd7e3376e683d35f90cc3f --- /dev/null +++ b/252/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "252", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/252/surgery_description.txt b/252/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4960e0fa7246bbf3339ec473ab174074484ec1e7 --- /dev/null +++ b/252/surgery_description.txt @@ -0,0 +1 @@ +Extended tonsillectomy diff --git a/252/surgery_report.txt b/252/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/253/InvasionFront_CD3_block18_x1_y5_patient253_0.json b/253/InvasionFront_CD3_block18_x1_y5_patient253_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dbef140332225f294f0ae5640a5f8e271f0b3a9c --- /dev/null +++ b/253/InvasionFront_CD3_block18_x1_y5_patient253_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 16891.1, + "Num Detections": 17780, + "Num Negative": 17568, + "Num Positive": 212, + "Positive %": 1.192, + "Num Positive per mm^2": 89.85 + } +} \ No newline at end of file diff --git a/253/InvasionFront_CD3_block18_x2_y5_patient253_1.json b/253/InvasionFront_CD3_block18_x2_y5_patient253_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0ddc9003d1c10c41b002ba9a032ebf03f903da9 --- /dev/null +++ b/253/InvasionFront_CD3_block18_x2_y5_patient253_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 16966.0, + "Num Detections": 19538, + "Num Negative": 18054, + "Num Positive": 1484, + "Positive %": 7.595, + "Num Positive per mm^2": 708.86 + } +} \ No newline at end of file diff --git a/253/InvasionFront_CD8_block18_x1_y5_patient253_0.json b/253/InvasionFront_CD8_block18_x1_y5_patient253_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ec5d400cededf009805a7384f9977efae8bc173f --- /dev/null +++ b/253/InvasionFront_CD8_block18_x1_y5_patient253_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4297.7, + "Centroid Y µm": 20189.3, + "Num Detections": 16371, + "Num Negative": 16277, + "Num Positive": 94, + "Positive %": 0.5742, + "Num Positive per mm^2": 39.42 + } +} \ No newline at end of file diff --git a/253/InvasionFront_CD8_block18_x2_y5_patient253_1.json b/253/InvasionFront_CD8_block18_x2_y5_patient253_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc85216ef6819bef55800b206ae5093a0e72285d --- /dev/null +++ b/253/InvasionFront_CD8_block18_x2_y5_patient253_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 20214.3, + "Num Detections": 23214, + "Num Negative": 22913, + "Num Positive": 301, + "Positive %": 1.297, + "Num Positive per mm^2": 118.14 + } +} \ No newline at end of file diff --git a/253/TumorCenter_CD3_block18_x1_y5_patient253_0.json b/253/TumorCenter_CD3_block18_x1_y5_patient253_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b67d22b643c25975326729e392cb68057f1533ad --- /dev/null +++ b/253/TumorCenter_CD3_block18_x1_y5_patient253_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3748.1, + "Centroid Y µm": 12044.1, + "Num Detections": 15579, + "Num Negative": 15549, + "Num Positive": 30, + "Positive %": 0.1926, + "Num Positive per mm^2": 12.66 + } +} \ No newline at end of file diff --git a/253/TumorCenter_CD3_block18_x2_y5_patient253_1.json b/253/TumorCenter_CD3_block18_x2_y5_patient253_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ce1cc4b2480af2f20df1b5281b2b24d3dda40c0 --- /dev/null +++ b/253/TumorCenter_CD3_block18_x2_y5_patient253_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 12068.6, + "Num Detections": 17368, + "Num Negative": 17092, + "Num Positive": 276, + "Positive %": 1.589, + "Num Positive per mm^2": 118.21 + } +} \ No newline at end of file diff --git a/253/TumorCenter_CD8_block18_x1_y5_patient253_0.json b/253/TumorCenter_CD8_block18_x1_y5_patient253_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1114d1247d7a3ff924c342e58e2e4838b974abc4 --- /dev/null +++ b/253/TumorCenter_CD8_block18_x1_y5_patient253_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 12868.2, + "Num Detections": 18573, + "Num Negative": 18503, + "Num Positive": 70, + "Positive %": 0.3769, + "Num Positive per mm^2": 30.3 + } +} \ No newline at end of file diff --git a/253/TumorCenter_CD8_block18_x2_y5_patient253_1.json b/253/TumorCenter_CD8_block18_x2_y5_patient253_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3aa2f2f4431cc3a5a8b5eb7b47c872e4c7d2d5ed --- /dev/null +++ b/253/TumorCenter_CD8_block18_x2_y5_patient253_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 12843.2, + "Num Detections": 19452, + "Num Negative": 19109, + "Num Positive": 343, + "Positive %": 1.763, + "Num Positive per mm^2": 143.75 + } +} \ No newline at end of file diff --git a/253/history_text.txt b/253/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..47f8541709259841024dde3130bbdce959a7d523 --- /dev/null +++ b/253/history_text.txt @@ -0,0 +1 @@ +Patient with a cT3 cN1 G3 confirmed squamous cell carcinoma in the interary region, thus indication for the above-mentioned measures. \ No newline at end of file diff --git a/253/icd_codes.txt b/253/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10623317f12e2cf8eb61e998e27f4b464b164dc5 --- /dev/null +++ b/253/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] \ No newline at end of file diff --git a/253/ops_codes.txt b/253/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d438272ca45ac84b99625e9187fa434418d81c0 --- /dev/null +++ b/253/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/253/patient_clinical_data.json b/253/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1438606e5b15b9bf4fab2d33a576386236a4812b --- /dev/null +++ b/253/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 71, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/253/patient_pathological_data.json b/253/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..348a42600d9d5ba1d7585269976981deb84c14ea --- /dev/null +++ b/253/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "253", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/253/surgery_description.txt b/253/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9a05c5d12bd5a57e586c48fa45d5fdf075e0c35d --- /dev/null +++ b/253/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Modified radical bilateral neck dissection stages I-V diff --git a/253/surgery_report.txt b/253/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d148edb07b2a6cdca79bcc7db1d080f6b817ba6 --- /dev/null +++ b/253/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia and ventilation of the patient via the existing tracheostoma. Laryngoscopy was then performed using a Kleinsasser C-tube. Inspection of the endolarynx, revealing an exophytic mass originating from the right interaryngeal region and affecting the posterior 2/3 of both vocal folds without significant subglottic spread. Thus verification of the indication. Skin spray disinfection. No local anesthesia after consultation with anesthesia colleagues. Cervical skin ablation and sterile draping. Creation of a skin incision, lifting of a subplatysmal apron flap. Placement of bridle sutures. Exposure and ligation of the anterior jugular vein with its branches. Exposure of the anterior border of the sternocleidomastoid muscle on the right side. Exposure and sparing of the right external jugular vein. Exposure and sparing of the right auricularis magnus nerve. Exposure of the right accessorius nerve, the posterior venter of the digaster muscle. Exposure of the submandibular gland. Exposure of the omohyoid muscle. Exposure of the cervical vascular sheath. Successive evacuation of the posterior and anterior neck preparation while sparing the above-mentioned structures and the plexus branches. This results in a modified radical neck dissection of regions Ib to V on the right side. Identical procedure on the left side. Dissection along the anterior border of the sternocleidomastoid muscle. Exposure and sparing of the accessorius nerve of the posterior venter of the digaster muscle and the omohyoid muscle. Exposure of the cervical vascular sheath. In region III on the left side there is a highly visible mass which can be easily detached from the cervical vascular sheath. Successive removal of the posterior and anterior neck specimen while sparing the above-mentioned structures of the plexus branches. The specimen is removed caudally and the removal frame is repositioned. Hemostasis on both sides using bipolar coagulation and subsequent skeletonization of the hyoid bone, skeletonization of the thyroid cartilage at its posterior ..................................... on both sides. Strict care is taken to ensure that the dissection is performed subperichondrally on the inner surface of the thyroid cartilage, thus sparing the piriform sinus as much as possible on both sides. Dissection of the prelaryngeal muscles at the level of the hyoid bone. Subsequent exposure of the free epiglottis margin and median pharyngotomy. Dissection along the lateral edge of the epiglottis on both sides and the aryepiglottic folds on both sides. Maximum protection of the pharyngeal mucosa in the area of the piriform sinus on both sides, transverse mucosal incision postcricoidally. Joining the lateral incision with this transverse incision and entering the region between the posterior wall of the trachea and the anterior wall of the oesophagus. Dissection caudally in this layer. Repeated hemostasis using bipolar coagulation. Dissection of the thyroid gland from the side wall of the trachea on both sides, inspection of the specimen from the caudal side and easy removal of the specimen at the level of the already inserted tracheostoma. A tracheal cartilage clip is then resected and sent with the specimen for final histology. The anterior border samples are then taken: posterior edge of the tracheal sedimentation, postcricoid mucosa, medial wall of the right piriform sinus, medial wall of the left piriform sinus, base of the tongue. All marginal samples were found to be tumor-free by the pathology colleagues. Subsequently, cricopharyngeal myotomy in the typical manner. Subsequently, three-layer pharyngeal suture (thin submucosal connective tissue layer, transversely striated pharyngeal wall muscles, prelingual residual muscles). The pharyngeal suture is then reinforced using several cut pieces of Tachosil. Dry conditions. Placement of 2 Redon drains on both sides. Completion of the epithelialization of the tracheostoma at its cranial and lateral edges. Two-layer wound closure. Application of a pressure dressing. Completion of the procedure without complications. Conclusion: Complete laryngectomy, modified radical neck dissection on both sides in regions Ib to V, control of the pharyngeal suture by means of an X-ray and suture removal on the 10th postoperative day. Prompt presentation of the patient to our tumor board after receipt of the final histology for the purpose of planning further therapy. \ No newline at end of file diff --git a/254/InvasionFront_CD3_block8_x5_y3_patient254_0.json b/254/InvasionFront_CD3_block8_x5_y3_patient254_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f6ae25b1be2f53750f2f9dedec59c53d953ee485 --- /dev/null +++ b/254/InvasionFront_CD3_block8_x5_y3_patient254_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 17765.6, + "Num Detections": 24549, + "Num Negative": 22731, + "Num Positive": 1818, + "Positive %": 7.406, + "Num Positive per mm^2": 689.24 + } +} \ No newline at end of file diff --git a/254/InvasionFront_CD3_block8_x6_y3_patient254_1.json b/254/InvasionFront_CD3_block8_x6_y3_patient254_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1c3a84c562112c7dcc4082b82f8674d36363cc75 --- /dev/null +++ b/254/InvasionFront_CD3_block8_x6_y3_patient254_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 17665.6, + "Num Detections": 19173, + "Num Negative": 18560, + "Num Positive": 613, + "Positive %": 3.197, + "Num Positive per mm^2": 254.34 + } +} \ No newline at end of file diff --git a/254/InvasionFront_CD8_block8_x5_y3_patient254_0.json b/254/InvasionFront_CD8_block8_x5_y3_patient254_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f73608ca0add2764104d7781074d95b034fc92e0 --- /dev/null +++ b/254/InvasionFront_CD8_block8_x5_y3_patient254_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17240.9, + "Centroid Y µm": 8020.8, + "Num Detections": 24756, + "Num Negative": 23991, + "Num Positive": 765, + "Positive %": 3.09, + "Num Positive per mm^2": 290.31 + } +} \ No newline at end of file diff --git a/254/InvasionFront_CD8_block8_x6_y3_patient254_1.json b/254/InvasionFront_CD8_block8_x6_y3_patient254_1.json new file mode 100644 index 0000000000000000000000000000000000000000..34b68a239aa71c6ca5201b19cc74cdcf5b3b5120 --- /dev/null +++ b/254/InvasionFront_CD8_block8_x6_y3_patient254_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19789.5, + "Centroid Y µm": 8395.6, + "Num Detections": 13124, + "Num Negative": 12723, + "Num Positive": 401, + "Positive %": 3.055, + "Num Positive per mm^2": 248.4 + } +} \ No newline at end of file diff --git a/254/TumorCenter_CD3_block8_x5_y3_patient254_0.json b/254/TumorCenter_CD3_block8_x5_y3_patient254_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a40782f6a6a8509baa9ffdc6b383a3896d508041 --- /dev/null +++ b/254/TumorCenter_CD3_block8_x5_y3_patient254_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15879.1, + "Centroid Y µm": 7920.8, + "Num Detections": 17970, + "Num Negative": 17150, + "Num Positive": 820, + "Positive %": 4.563, + "Num Positive per mm^2": 338.85 + } +} \ No newline at end of file diff --git a/254/TumorCenter_CD3_block8_x6_y3_patient254_1.json b/254/TumorCenter_CD3_block8_x6_y3_patient254_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5b0eef271e1329b9b2883df21c3df5f73db215ae --- /dev/null +++ b/254/TumorCenter_CD3_block8_x6_y3_patient254_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18315.3, + "Centroid Y µm": 7633.5, + "Num Detections": 15116, + "Num Negative": 14295, + "Num Positive": 821, + "Positive %": 5.431, + "Num Positive per mm^2": 374.13 + } +} \ No newline at end of file diff --git a/254/TumorCenter_CD8_block8_x5_y3_patient254_0.json b/254/TumorCenter_CD8_block8_x5_y3_patient254_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d83726c48cabc72e4340d11b15869c98461979f0 --- /dev/null +++ b/254/TumorCenter_CD8_block8_x5_y3_patient254_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 7770.9, + "Num Detections": 20074, + "Num Negative": 19933, + "Num Positive": 141, + "Positive %": 0.7024, + "Num Positive per mm^2": 56.67 + } +} \ No newline at end of file diff --git a/254/TumorCenter_CD8_block8_x6_y3_patient254_1.json b/254/TumorCenter_CD8_block8_x6_y3_patient254_1.json new file mode 100644 index 0000000000000000000000000000000000000000..796aac9d35ae12e81cb0699cef04abe4a0fcde7a --- /dev/null +++ b/254/TumorCenter_CD8_block8_x6_y3_patient254_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 7596.0, + "Num Detections": 22416, + "Num Negative": 22171, + "Num Positive": 245, + "Positive %": 1.093, + "Num Positive per mm^2": 100.15 + } +} \ No newline at end of file diff --git a/254/history_text.txt b/254/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c14029a772c9bfc5d3f2c0b519db6a95b87e64a9 --- /dev/null +++ b/254/history_text.txt @@ -0,0 +1 @@ +During a panendoscopy <2013>, an externally confirmed, poorly differentiated and HPV-negative squamous cell carcinoma in the area of the right oropharynx and oral cavity was histologically confirmed. In our interdisciplinary tumor conference, primary surgical treatment was indicated. Sonographically, a cN1 neck status on the right was suspected. \ No newline at end of file diff --git a/254/icd_codes.txt b/254/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/254/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/254/ops_codes.txt b/254/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a926e91afddf413ef39e077b642d08fba9d225bd --- /dev/null +++ b/254/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Entnahme freier Radialis-Lappen[5-858.23 L] Vollhaut Entnahmestelle Leisten- und Genitalregion[5-901.1c ] Permanente Tracheostomaanlage[5-312.0 ] Perkutane [endoskopische] Gastrostomie [PEG][5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Endovaskuläre Implantation Stent-Prothese sonstige Blutgefäße[5-38a.x ] Kontinuierliche Sogbehandlung mit Pumpensystem bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.20 ] Exzision Hautnävus ohne Wundverschluss sonstige Teile Kopf[5-894.04 ] \ No newline at end of file diff --git a/254/patient_clinical_data.json b/254/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e067a286e8b6fa9b04ef7aac0e839fed3f5a1838 --- /dev/null +++ b/254/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 56, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 70, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/254/patient_pathological_data.json b/254/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1d76b6426c348a333350d7bfe826fbf3c38bfc32 --- /dev/null +++ b/254/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "254", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/254/surgery_description.txt b/254/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bdf42ac892f5634b112ce0961e4392e42e387db9 --- /dev/null +++ b/254/surgery_description.txt @@ -0,0 +1 @@ +Pharyngeal partial resection, Neck dissection, Free flap coverage (ALT) diff --git a/254/surgery_report.txt b/254/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..394549adfa11398ea73f952bcd60946cfe495d72 --- /dev/null +++ b/254/surgery_report.txt @@ -0,0 +1 @@ +First confirmation of the extent. There is an exophytic tumor of the right tonsillar lobe, completely consuming the tonsillar lobe with transition to the soft palate up to the right-sided uvula base. In addition, the tumor extends slightly over the caudal tonsillar lobe, growth over the glossotonsillar groove to the free edge of the tongue on the right and here infiltration of an area of the tongue measuring approx. 3 cm with a penetration depth of approx. 1 cm. Infiltration also of the circumscribed posterior floor of the mouth. The PEG tube is inserted first. For this, insertion with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach. With good diaphanoscopy, problem-free puncture of the stomach. The PEG tube is then inserted using the usual suture pull-through method. Transoral tumor resection is now performed. The tumor is cut around with a safety margin of 1 cm. Removal of the uvula and subtotal removal of the soft palate. Resection up to the buccal. Release of the tooth pocket of the posterior mandibular tooth; if close to the tumour, push off the periosteum here and thus achieve good mobilization in the area of the posterior floor of the mouth. The floor of the mouth is also resected with a safety margin of 1 cm. Resection of the tongue section with a safety margin of approx. 1.5 cm. Also safe in sano resection in depth. Basal resection up to the submandibular gland. The tumor area is now completely covered with marginal samples. These are all assessed as free of dysplasia and tumor. Only in the area of the base of the tongue is there an unclear change that cannot be further differentiated histologically. For this reason, a resection is performed later, which is again assessed as completely tumor-free and dysplasia-free. This results in a defect of the posterior floor of the mouth, the edge and base of the tongue, the lateral wall of the pharynx, the posterior wall of the pharynx and subtotally the soft palate. Therefore a clear indication for defect reconstruction. Neck dissection of the left side is performed first. To do this, make a skin incision on the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Dissection of the platysma. Exposure of the sternocleidomastoid, digastric and omohyoid muscles. Exposure and release of the capsule of the submandibular gland. Subsequent evacuation of levels II a to V a with careful preservation of the facial vein, superior thyroid artery, hypoglossal nerve and accessorius nerve as well as the cervical plexus branches. Final wound inspection. If the wound is dry, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Macroscopically, there are no suspicious nodules. Neck dissection is now performed on the opposite side. The procedure is basically the same here. However, in the area of the jugular facial angle, a coarse and therefore highly visible mass measuring approx. 2 cm can be seen. This can ultimately be extirpated while preserving the facial vein, without definite evidence of perinodal growth. Otherwise, after release of the submandibular gland, in addition to levels II a and V a, while sparing the structures already mentioned on the opposite side. Release of level I b. Here several macroscopic but not suspicious nodules. Subsequent extirpation of the gland. Partial resection of the digastric muscle and thus creation of a wide access to the enoral side, good overview. Protection of the hypoglossal nerve is possible. The radialis graft is now removed. After marking the graft specially configured for the tongue edge and soft palate, cut around the graft. Expose the cephalic vein. Exposure of the superficial ramus, radial nerve, which can be preserved. Exposure of the distal vascular pedicle. Release of the radial artery. Strictly subfascial dissection. The cephalic vein shows no confluence with the deep venous system in the antecubital region, so it is clipped later and not used further. Exposure of a venous confluence and a further venous outflow. Exposure and preservation of the ulnar artery and common interosseous artery. Later, with a normal vital graft and normal blood supply to the hand, removal of the graft after ligation of the feeding and draining vessels. Careful hemostasis. Subsequent careful two-layer wound closure and insertion of the full-thickness skin graft harvested from the right groin. Application of the vacuum pump and application of the Cramer splint in the functional position for full-thickness skin harvesting from the right groin. For this purpose, cutting around an area of skin measuring a good 12 x 7 cm. Strict cutaneous elevation, subcutaneous mobilization. Insertion of a 10 Redon drain. Multi-layered subcutaneous wound closure and skin suture. The graft is now inserted. This is considerably more difficult due to the swelling that has now occurred. Overall, however, sufficient reconstruction of the defect is achieved, combined transorally and transcervically. Positioning of the stem. Preparation of the facial artery in the case of a very slender superior thyroid artery. Passage of the artery in anastomosis with 8-0 Ethilon. Finally, regular venous return via the draining veins. First condition the superior thyroid vein. Perform a venous anastomosis with the coupler system using a coupler size 3.0. There is now largely strong venous return via the second vein. The facial vein is therefore also conditioned and a further venous anastomosis is performed with the size 3.5 coupler. Regular circulation is then achieved. Positive smear tests and excellent graft perfusion, so that a size 10 Redon drain is subsequently inserted and the wound is closed in two layers. Due to the advanced swelling, a final protective tracheostomy is performed. This involves a skin incision at the level of the cricoid cartilage. Cut through the skin and sucutaneous tissue. Entering the infrahyoid musculature. Exposure of the cricoid cartilage and the anterior wall of the trachea. Dissection of the thin thyroid isthmus. Subsequent insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björk flap. Subsequent problem-free transfer to a size 8 low-cuff cannula, which is suture-fixed. Conclusion: Intraoperative R0 resected cT3 cN1 oropharyngeal/oral cavity carcinoma on the right. If the graft heals properly and the graft is intact, a gradual diet can be started from the 8th postoperative day after inspection. Decannulation should be possible in a timely manner. \ No newline at end of file diff --git a/255/InvasionFront_CD3_block18_x5_y12_patient255_0.json b/255/InvasionFront_CD3_block18_x5_y12_patient255_0.json new file mode 100644 index 0000000000000000000000000000000000000000..302d1d896b5f4e57e2fece006f2280f746cdff2a --- /dev/null +++ b/255/InvasionFront_CD3_block18_x5_y12_patient255_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15466.8, + "Centroid Y µm": 34806.6, + "Num Detections": 17281, + "Num Negative": 16725, + "Num Positive": 556, + "Positive %": 3.217, + "Num Positive per mm^2": 286.94 + } +} \ No newline at end of file diff --git a/255/InvasionFront_CD3_block18_x6_y12_patient255_1.json b/255/InvasionFront_CD3_block18_x6_y12_patient255_1.json new file mode 100644 index 0000000000000000000000000000000000000000..93451b83790df794f94e48f0c98bf8c7979fd262 --- /dev/null +++ b/255/InvasionFront_CD3_block18_x6_y12_patient255_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17790.6, + "Centroid Y µm": 35006.5, + "Num Detections": 15221, + "Num Negative": 14146, + "Num Positive": 1075, + "Positive %": 7.063, + "Num Positive per mm^2": 573.55 + } +} \ No newline at end of file diff --git a/255/InvasionFront_CD8_block18_x5_y12_patient255_0.json b/255/InvasionFront_CD8_block18_x5_y12_patient255_0.json new file mode 100644 index 0000000000000000000000000000000000000000..12c0bcab6f729ca9c69af2b0f8e5e38543d54c82 --- /dev/null +++ b/255/InvasionFront_CD8_block18_x5_y12_patient255_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 36905.5, + "Num Detections": 17262, + "Num Negative": 16998, + "Num Positive": 264, + "Positive %": 1.529, + "Num Positive per mm^2": 141.33 + } +} \ No newline at end of file diff --git a/255/InvasionFront_CD8_block18_x6_y12_patient255_1.json b/255/InvasionFront_CD8_block18_x6_y12_patient255_1.json new file mode 100644 index 0000000000000000000000000000000000000000..62424e3cac232f83b5db24264ddb0e7f45f3304e --- /dev/null +++ b/255/InvasionFront_CD8_block18_x6_y12_patient255_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 36855.5, + "Num Detections": 16232, + "Num Negative": 15568, + "Num Positive": 664, + "Positive %": 4.091, + "Num Positive per mm^2": 383.83 + } +} \ No newline at end of file diff --git a/255/TumorCenter_CD3_block18_x5_y12_patient255_0.json b/255/TumorCenter_CD3_block18_x5_y12_patient255_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4fd8128445bb321a20cec44a911289fc5341ea6f --- /dev/null +++ b/255/TumorCenter_CD3_block18_x5_y12_patient255_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15522.1, + "Centroid Y µm": 28992.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/255/TumorCenter_CD3_block18_x6_y12_patient255_1.json b/255/TumorCenter_CD3_block18_x6_y12_patient255_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c30c7dd0b2752a14071506fc9d07c29bae9f88a9 --- /dev/null +++ b/255/TumorCenter_CD3_block18_x6_y12_patient255_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17810.3, + "Centroid Y µm": 29067.7, + "Num Detections": 10266, + "Num Negative": 10088, + "Num Positive": 178, + "Positive %": 1.734, + "Num Positive per mm^2": 99.68 + } +} \ No newline at end of file diff --git a/255/TumorCenter_CD8_block18_x5_y12_patient255_0.json b/255/TumorCenter_CD8_block18_x5_y12_patient255_0.json new file mode 100644 index 0000000000000000000000000000000000000000..46d6c898ea5186ade910f58b1e7be20fec88a2fb --- /dev/null +++ b/255/TumorCenter_CD8_block18_x5_y12_patient255_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15491.8, + "Centroid Y µm": 29959.1, + "Num Detections": 15382, + "Num Negative": 15300, + "Num Positive": 82, + "Positive %": 0.5331, + "Num Positive per mm^2": 43.69 + } +} \ No newline at end of file diff --git a/255/TumorCenter_CD8_block18_x6_y12_patient255_1.json b/255/TumorCenter_CD8_block18_x6_y12_patient255_1.json new file mode 100644 index 0000000000000000000000000000000000000000..373483173bd9fc9895b3a750526de32a75f8ed52 --- /dev/null +++ b/255/TumorCenter_CD8_block18_x6_y12_patient255_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17865.5, + "Centroid Y µm": 29984.1, + "Num Detections": 15957, + "Num Negative": 15837, + "Num Positive": 120, + "Positive %": 0.752, + "Num Positive per mm^2": 64.69 + } +} \ No newline at end of file diff --git a/255/history_text.txt b/255/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/255/icd_codes.txt b/255/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/255/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/255/ops_codes.txt b/255/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..75a88c8c7f12660485192c0ba3ef502d45696424 --- /dev/null +++ b/255/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Resektion [erkranktes Gewebe] Trachea mit Anlegen eines Tracheostoma[5-314.12 ] Hemithyroidektomie ohne Parathyreoidektomie[5-061.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/255/patient_clinical_data.json b/255/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..47a82c74da5f6a7805aceda93e0ac350ad198dd2 --- /dev/null +++ b/255/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 62, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 6, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/255/patient_pathological_data.json b/255/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..af48d6f801fca1ef8e37a6ddbd2efdd82cd31f60 --- /dev/null +++ b/255/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "255", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 8, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/255/surgery_description.txt b/255/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..78e230c3a5ee93a24257397c8e406693df93e79b --- /dev/null +++ b/255/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Partial tracheal resection, Tracheal high pull-up, PEG placement diff --git a/255/surgery_report.txt b/255/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3976dc7d40b81c8d399c0eed0cffc28296c802df --- /dev/null +++ b/255/surgery_report.txt @@ -0,0 +1 @@ +At the beginning of the procedure, the trachea, the larynx transorally and via the tracheostoma are inspected again. A fixed arytenoid of the left side with a tumor extending into the vocal fold is seen, which then encircles the endolarynx and extends dorsally into the trachea. Here the tumor extends to the level of the tracheostoma. Due to the infiltration of the left arytenoid and the fixed vocal fold on both sides, a partial laryngectomy is not possible here, so that the indication for LE is established and confirmed. The patient is then repositioned for PEG insertion and a nasogastric feeding tube is inserted. Both are successful without any problems. During PEG insertion, the flexible instrument is inserted into the esophagus without any problems and the tube is advanced into the stomach under visualization. The patient has a history of abdominal surgery. Ceftriaxone was administered in advance as a prophylactic antibiotic. Diaphanoscopy shows positive paramedian on the left side below the costal arch. Then PEG placement with positive tenting phenomenon using the thread pull-through method. This is successful without any problems. Fixation of the PEG tube and bandaging. The patient is then repositioned and local anesthetic with adrenaline is injected preauricularly. Then separation of the prelaryngeal muscles via the larynx. Dissection onto the laryngeal skeleton. Dissection caudally after detachment of the infrahyoid musculature. Exposure of the anterior surface of the trachea. Exposure of the thyroid glands on both sides. When the muscles are opened precricoidally, a pronounced infiltration by the tumor can be seen, which is clearly growing into the thyroid gland in a paramedian direction. Therefore, the thyroid glands are released on the left side and a left hemithyroidectomy is performed. There is also an infiltration just in the area of the right thyroid gland and postcricoid. Representative marginal samples are taken. A positive marginal sample is seen on the right side, so that a partial resection must also be performed in the area of the thyroid gland. The removal of the marginal sample and its findings in the area of the anterior esophageal wall as well as in the remaining postcricoid region and the pharynx are unremarkable, so that an R0 resection can now be assumed. The radiology colleagues are now consulted again to assess the external CT images with regard to the final status. This revealed a cN0 status, which was also confirmed preoperatively in the ultrasound sonography. Due to the extent of the tumor growth locally on the larynx and in the area of the trachea, adjuvant therapy is certainly advisable for the patient. Accordingly, the patient does not appear to benefit from a lymph node resection as in a neck dissection on both sides, so that after a detailed intraoperative discussion of the findings, a neck dissection on both sides is not performed. The further procedure must then be decided at the interdisciplinary tumor conference depending on the final histopathological findings. Now mobilize the trachea by removing all tissue and cutting the pulmonary ligament. This allows the trachea to be mobilized sufficiently cranially. Insertion of 2 retaining sutures. Then closure of the pharyngostoma with single button sutures. A total of three-layer closure here. Then resection of the anterior edge of the sternocleidomastoid muscle. Before closing the pharyngostoma, perform the lateral myotomy on the left side. Now circular suturing of the trachea in the sense of a mucocutaneous anastomosis. This succeeds effortlessly so that the retaining sutures, which had been fixed to the hyoid bone in the meantime, can now be removed. A Redon drain is then inserted, followed by two-layer skin closure and application of a pressure bandage. Insertion of the size 9 tracheostomy tube, which should not be changed until the 5th or 6th postoperative day if possible. The patient is then transferred to the in-house intensive care unit. Due to the hemithyroidectomy on the left side and an epithelial body in the area of the postcricoid margin and thyroid gland on the right, regular calcium monitoring should be carried out here. The nasogastric tube was removed during the recovery phase. An X-ray pre-swallow examination should be performed on the 10th postoperative day. \ No newline at end of file diff --git a/256/InvasionFront_CD3_block4_x5_y12_patient256_0.json b/256/InvasionFront_CD3_block4_x5_y12_patient256_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8a81dc39032a148be65e65d89b877fa11b2ce5fa --- /dev/null +++ b/256/InvasionFront_CD3_block4_x5_y12_patient256_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 36355.8, + "Num Detections": 20480, + "Num Negative": 20401, + "Num Positive": 79, + "Positive %": 0.3857, + "Num Positive per mm^2": 38.11 + } +} \ No newline at end of file diff --git a/256/InvasionFront_CD3_block4_x6_y12_patient256_1.json b/256/InvasionFront_CD3_block4_x6_y12_patient256_1.json new file mode 100644 index 0000000000000000000000000000000000000000..06fc69923fce8b2c880f04cd327dd992e4fc3b89 --- /dev/null +++ b/256/InvasionFront_CD3_block4_x6_y12_patient256_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20963.9, + "Centroid Y µm": 36380.7, + "Num Detections": 20949, + "Num Negative": 19230, + "Num Positive": 1719, + "Positive %": 8.206, + "Num Positive per mm^2": 805.97 + } +} \ No newline at end of file diff --git a/256/InvasionFront_CD8_block4_x5_y12_patient256_0.json b/256/InvasionFront_CD8_block4_x5_y12_patient256_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fc2e9f6805bd227a134bd38fa2f7c64321554a53 --- /dev/null +++ b/256/InvasionFront_CD8_block4_x5_y12_patient256_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 35356.3, + "Num Detections": 21893, + "Num Negative": 21860, + "Num Positive": 33, + "Positive %": 0.1507, + "Num Positive per mm^2": 14.14 + } +} \ No newline at end of file diff --git a/256/InvasionFront_CD8_block4_x6_y12_patient256_1.json b/256/InvasionFront_CD8_block4_x6_y12_patient256_1.json new file mode 100644 index 0000000000000000000000000000000000000000..60faf736679435e480fd2c9ac130b519863d3cee --- /dev/null +++ b/256/InvasionFront_CD8_block4_x6_y12_patient256_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 35456.2, + "Num Detections": 22099, + "Num Negative": 21939, + "Num Positive": 160, + "Positive %": 0.724, + "Num Positive per mm^2": 71.0 + } +} \ No newline at end of file diff --git a/256/TumorCenter_CD3_block4_x5_y12_patient256_0.json b/256/TumorCenter_CD3_block4_x5_y12_patient256_0.json new file mode 100644 index 0000000000000000000000000000000000000000..496a1531d6ad18abae7fb79fd20ce1480865a7fd --- /dev/null +++ b/256/TumorCenter_CD3_block4_x5_y12_patient256_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 30758.7, + "Num Detections": 22634, + "Num Negative": 19169, + "Num Positive": 3465, + "Positive %": 15.31, + "Num Positive per mm^2": 1457.5 + } +} \ No newline at end of file diff --git a/256/TumorCenter_CD3_block4_x6_y12_patient256_1.json b/256/TumorCenter_CD3_block4_x6_y12_patient256_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dd28716997d0c43246f8f47efc2ebf0af07e020d --- /dev/null +++ b/256/TumorCenter_CD3_block4_x6_y12_patient256_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 30633.8, + "Num Detections": 18605, + "Num Negative": 18302, + "Num Positive": 303, + "Positive %": 1.629, + "Num Positive per mm^2": 128.64 + } +} \ No newline at end of file diff --git a/256/TumorCenter_CD8_block4_x5_y12_patient256_0.json b/256/TumorCenter_CD8_block4_x5_y12_patient256_0.json new file mode 100644 index 0000000000000000000000000000000000000000..188ab2e84f705aea1cdddd54049f9e6fde988071 --- /dev/null +++ b/256/TumorCenter_CD8_block4_x5_y12_patient256_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15791.6, + "Centroid Y µm": 30983.6, + "Num Detections": 23981, + "Num Negative": 23437, + "Num Positive": 544, + "Positive %": 2.268, + "Num Positive per mm^2": 234.1 + } +} \ No newline at end of file diff --git a/256/TumorCenter_CD8_block4_x6_y12_patient256_1.json b/256/TumorCenter_CD8_block4_x6_y12_patient256_1.json new file mode 100644 index 0000000000000000000000000000000000000000..95cf810d20ac91e23ab9ae729c7a2ca4c8d8abcc --- /dev/null +++ b/256/TumorCenter_CD8_block4_x6_y12_patient256_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18315.3, + "Centroid Y µm": 31058.6, + "Num Detections": 21654, + "Num Negative": 21527, + "Num Positive": 127, + "Positive %": 0.5865, + "Num Positive per mm^2": 52.68 + } +} \ No newline at end of file diff --git a/256/history_text.txt b/256/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/256/icd_codes.txt b/256/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8f922ec295b373fb00f93994edcbe6ec8f289730 --- /dev/null +++ b/256/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 L] \ No newline at end of file diff --git a/256/ops_codes.txt b/256/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..988f8e81f0cb0163803318451ade07e920032cf9 --- /dev/null +++ b/256/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Temporäre Tracheotomie[5-311.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Spalthaut Entnahmestelle sonstige[5-901.0x R] Spalthaut kleinflächig Empfängerstelle sonstige[5-902.0x R] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/256/patient_clinical_data.json b/256/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..249e4a63d459e4ef94e9332720c456a1295ff55b --- /dev/null +++ b/256/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 39, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 36, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/256/patient_pathological_data.json b/256/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e50972942720c9060a251e45ff2d33e0c1ec9d89 --- /dev/null +++ b/256/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "256", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/256/surgery_description.txt b/256/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..34faed1cd3f18c05ecb485548f6cef36f9f9a6dd --- /dev/null +++ b/256/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy, Bilateral neck dissection, Tracheotomy, PEG placement, Defect coverage, Free flap (Radial) diff --git a/256/surgery_report.txt b/256/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a697a368162e09d39958992e70d63aaf366855ef --- /dev/null +++ b/256/surgery_report.txt @@ -0,0 +1 @@ +Tracheotomy: After demonstration of the findings on , a tracheotomy is performed with a longitudinal incision to avoid an apron flap if bilateral neck dissection is necessary. Injection of 5 ml Ultracaine with Suprarenin added. Cauterization and sterile draping. Incision between the cricoid cartilage and a point three transverse fingers above the jugulum measuring approx. 5 cm. Now cut through the skin, subcutaneous tissue and platysma with a 15 mm scalpel. Enter with the pointed scissors and expose the infrahyoid musculature, linea alba and finally the thyroid gland. Incision with the Overholt clamp below the isthmus, the thyroid gland, between the thyroid gland and the trachea. Bipolar coagulation of the isthmus and transection of the isthmus. No injury to the surrounding structures. Truncus is checked or palpated and not injured. Now insertion between the second and retrotracheal ring and creation of a visor tracheotomy in the typical manner. The mucocutaneous anastomosis is performed without difficulty using Ethibond sutures. PEG insertion: Insertion with the flexible gastroesophagoscope and, under air insufflation, pre-scanning into the stomach. Gastric mucosa unremarkable, without irritation. Inversion shows no tumor in the cardia. A spontaneous diaphanoscopy is performed in loco typico, paramedian left, three transverse fingers below the ribs. A PEG is then inserted at this site using the thread pull-through method without any problems. Traction loosening should take place in 24 hours. The patient received Unacid 3 g i.v. perioperatively. Tumor resection and neck dissection on the left. After positioning and sterile washing and draping of the patient, insertion of the McIvor mouth blocker and inspection of the tumor region. The tumor extends from the left tonsil onto the anterior palatal arch up to the uvula and caudally to the glossotonsillar groove and the base of the tongue. The resection is first started with the monopolar needle in the area of the soft palate. Safety distance 1 to 1.5 cm. The entire anterior palatal arch must be removed. Then move on to the tonsil region. Further dissection with scissors and bipolar forceps so that the tonsil is removed together with the tumor tissue. The musculature must also be removed in depth and the soft tissues of the neck are accessed. The neck fat becomes visible. Then further dissection in the area of the glossotonsillar groove and the base of the tongue, part of the base of the tongue is also removed. Medially, the largest parts of the posterior palatal arch are also removed due to tumor infiltration. The specimen is placed on cork for frozen section. The frozen section still shows moderate dysplasia in the area of the soft palate. A superficial resection is performed and a marginal sample is sent to the frozen section. This is then tumor-free. Then transition to neck dissection on the left side. Skin incision in a transverse skin fold. Exposure of the sternocleidomastoid muscle. Exposure of the submandibular gland. Exposure of the omohyoid muscle and exposure of the cervical vascular sheath. Removal of the neck preparation II a to V a, sparing the plexus branches. The accessorius nerve and hypoglossal nerve are exposed and spared. Now widen the opening enorally so that 3 transverse fingers can be comfortably inserted into the mouth area. The flap pedicle is to be pulled through here later. Now dissect the connecting vessels. Dissection of the superior thyroid and facial vein as well as the external jugular vein. The patient has a good vascular situation and several options for connection. Radialis flap: Palpatory identification of the distal radial artery. Marking of the flap boundaries (size) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Covering of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Neck dissection on the right: injection of 10 ml Suprarenin along the skin incision on the front edge of the right sternocleidomastoid muscle. Use the 15 mm scalpel to sharply cut through the skin, subcutaneous tissue and platysma. The external jugular vein is now ligated. The ramus auricularis magnus is severed. Dissection of the platysma flap and dissection along the anterior edge of the sternocleidomastoid muscle. Exposure of the cervical vascular sheath. The accessorius nerve is explored cranially. The nerve can be visualized without difficulty. The nerve is traced cranially to the posterior belly of the digastric muscle. The posterior belly of the GSM is also visualized. The omohyoid muscle is dissected and traced cranially. The jugular vein is now dissected from caudal to cranial. Level II b is detached, followed by II a, III, IV and V in depth. The ACC and the vagus nerve are exposed and spared. The anterior neck preparation is detached from the internal jugular vein and facial vein without any problems. The hypoglossal nerve is exposed and spared. Hemostasis using bipolar forceps. At the end of the procedure, there is no bleeding. Placement of a 10 Redon drain. Platysma suture using 4.0 Vicryl and skin suture using 4.0 Ethilon. The nervus accessorius showed an anatomical variant and ran above the jugular vein. The nerve was also spared. After removal of the graft, it is rinsed with heparin, then the flap is sutured into the defect: first sutures are placed, the graft is inserted and the pedicle is passed through the large tunnel. The flap is successively sutured into the defect with 3-0 Vicryl single-button sutures, folded in the palatal arch area. This results in tension-free, complete defect coverage. The superior thyroid artery and radial artery are then conditioned for vascular anastomosis. This is performed with 8-0 Ethilon single-button sutures. After opening the clamps, good arterial flow, good venous return. Subsequent conditioning of the veins, here conditioning of the two outflows from the superficial venous system. The deep venous system is clipped in the course of the operation. Two outlets of the facial vein are selected, the larger outlet is anastomosed with the larger outlet of the cephalic vein after conditioning the veins using a 3-0 vascular coupler. Here, after opening the clamp, good venous return, positive smear phenomenon. The smaller vein with a smaller outlet from the facial vein is then anastomosed using a 2-0 coupler. Here too, after opening the clamp, good venous return, positive smear phenomenon. Subsequent irrigation of the wound area. Wound closure in layers with insertion of a Redon drain on the right and 2 flaps on the left. Subsequently, after epithelialization of the tracheostoma, fixation of the cannula using sutures. Close inspection of the flap. This is vital. The procedure is then completed without complications. The patient is ventilated postoperatively for monitoring in the intensive care unit. Please continue antibiotics, which were started intraoperatively with Unacid, for 1 week. Continue heparin perfusor 500 units per hour for a total of 5 days. Flap control according to the scheme for 5 days, both clinically and by Doppler sonography. A suture marker was placed on the left side of the neck for this purpose. Feeding via the PEG tube for approx. 10 days, then gruel swallowing and, if necessary, diet build-up. After receiving the final histology, presentation at the interdisciplinary tumor conference to plan further treatment. \ No newline at end of file diff --git a/257/InvasionFront_CD3_block9_x3_y4_patient257_0.json b/257/InvasionFront_CD3_block9_x3_y4_patient257_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d09cb4b33e00d44436e0b460492b6be4db5c1893 --- /dev/null +++ b/257/InvasionFront_CD3_block9_x3_y4_patient257_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13218.0, + "Centroid Y µm": 10694.3, + "Num Detections": 18598, + "Num Negative": 18300, + "Num Positive": 298, + "Positive %": 1.602, + "Num Positive per mm^2": 117.75 + } +} \ No newline at end of file diff --git a/257/InvasionFront_CD3_block9_x4_y4_patient257_1.json b/257/InvasionFront_CD3_block9_x4_y4_patient257_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b20120ae60b77cb8418d79f3552c351fd9530c02 --- /dev/null +++ b/257/InvasionFront_CD3_block9_x4_y4_patient257_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15866.6, + "Centroid Y µm": 10894.2, + "Num Detections": 19554, + "Num Negative": 19140, + "Num Positive": 414, + "Positive %": 2.117, + "Num Positive per mm^2": 177.12 + } +} \ No newline at end of file diff --git a/257/InvasionFront_CD8_block9_x3_y4_patient257_0.json b/257/InvasionFront_CD8_block9_x3_y4_patient257_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c5e15d4f9c53cfca54b4f2d5f17f7a2af5973d1c --- /dev/null +++ b/257/InvasionFront_CD8_block9_x3_y4_patient257_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12843.2, + "Centroid Y µm": 14742.2, + "Num Detections": 18829, + "Num Negative": 18741, + "Num Positive": 88, + "Positive %": 0.4674, + "Num Positive per mm^2": 35.3 + } +} \ No newline at end of file diff --git a/257/InvasionFront_CD8_block9_x4_y4_patient257_1.json b/257/InvasionFront_CD8_block9_x4_y4_patient257_1.json new file mode 100644 index 0000000000000000000000000000000000000000..75cd7069a729efe6909121761c5093f12502c8f5 --- /dev/null +++ b/257/InvasionFront_CD8_block9_x4_y4_patient257_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15441.8, + "Centroid Y µm": 14767.2, + "Num Detections": 20956, + "Num Negative": 20775, + "Num Positive": 181, + "Positive %": 0.8637, + "Num Positive per mm^2": 76.05 + } +} \ No newline at end of file diff --git a/257/TumorCenter_CD3_block9_x3_y4_patient257_0.json b/257/TumorCenter_CD3_block9_x3_y4_patient257_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1c230d9cf606fa372f033336b34385b46c9f4a59 --- /dev/null +++ b/257/TumorCenter_CD3_block9_x3_y4_patient257_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11568.9, + "Centroid Y µm": 15716.7, + "Num Detections": 13582, + "Num Negative": 13092, + "Num Positive": 490, + "Positive %": 3.608, + "Num Positive per mm^2": 205.46 + } +} \ No newline at end of file diff --git a/257/TumorCenter_CD3_block9_x4_y4_patient257_1.json b/257/TumorCenter_CD3_block9_x4_y4_patient257_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf840c8ce5a3f6e0e50d4436f372ae8fe8008e51 --- /dev/null +++ b/257/TumorCenter_CD3_block9_x4_y4_patient257_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14167.5, + "Centroid Y µm": 15816.6, + "Num Detections": 16168, + "Num Negative": 14788, + "Num Positive": 1380, + "Positive %": 8.535, + "Num Positive per mm^2": 577.94 + } +} \ No newline at end of file diff --git a/257/TumorCenter_CD8_block9_x3_y4_patient257_0.json b/257/TumorCenter_CD8_block9_x3_y4_patient257_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d86fb1f58dfb975028eaf652da55d0c9bf80f49c --- /dev/null +++ b/257/TumorCenter_CD8_block9_x3_y4_patient257_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 10819.3, + "Num Detections": 14839, + "Num Negative": 14706, + "Num Positive": 133, + "Positive %": 0.8963, + "Num Positive per mm^2": 63.69 + } +} \ No newline at end of file diff --git a/257/TumorCenter_CD8_block9_x4_y4_patient257_1.json b/257/TumorCenter_CD8_block9_x4_y4_patient257_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ea385f7274ef7f75224f01a212fe0bd06cb6a2dc --- /dev/null +++ b/257/TumorCenter_CD8_block9_x4_y4_patient257_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 10869.2, + "Num Detections": 11514, + "Num Negative": 10943, + "Num Positive": 571, + "Positive %": 4.959, + "Num Positive per mm^2": 369.79 + } +} \ No newline at end of file diff --git a/257/history_text.txt b/257/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/257/icd_codes.txt b/257/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..80aa6bc6a661911edb96f432dd45e064c7a9912b --- /dev/null +++ b/257/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Aryepiglottische Falte, hypopharyngeale Seite[C13.1 ] Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/257/ops_codes.txt b/257/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7926f23c5249b0735330ca5441bea355df2ec068 --- /dev/null +++ b/257/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 R] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Entnahme Spalthaut zur Transplantation Unterarm[5-901.08 L] Permanente Tracheotomie[5-312.0 ] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/257/patient_clinical_data.json b/257/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6fc853a162dab009cdfcfa5cb52afb5833749f6e --- /dev/null +++ b/257/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/257/patient_pathological_data.json b/257/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2a40a314b5aa0c6e8697156d84924d2d8b98d2eb --- /dev/null +++ b/257/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "257", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/257/surgery_description.txt b/257/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0d8e223131c695c837392fa47c8794fe7b601c0 --- /dev/null +++ b/257/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Free flap (Radial), Tracheotomy diff --git a/257/surgery_report.txt b/257/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..de6b96f42a4e0820b57f29b00179ace6d4a2ec99 --- /dev/null +++ b/257/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia and intubation transnasally by the anesthesia colleagues. Then, entry with the Kleinsasser tube and inspection of the tumor. The tumor starts at the lower edge of the left tonsil and extends over the entire oropharyngeal side wall on the left side to the left vallecula and epiglottis edge, then sterile washing and draping and insertion of a Mc Ivor mouth block and start with a transoral tumor resection with a safety margin of 1 cm to 1.5 cm. Then repositioning for neck dissection on the left side. Skin incision at the anterior margin of the sternocleidomastoid muscle, exposure of the sternocleidomastoid muscle, the omohyoid of the submandibular gland, the digaster and the accessorius nerve, exposure of the cervical vascular sheath and exposure of the internal jugular vein. It becomes clear that there is a metastasis in level II that cannot be separated from the internal jugular vein, so the neck dissection is temporarily stopped on the left side and the procedure is switched to the opposite side so that the internal jugular vein can be safely preserved there. Here also skin incision in the usual manner. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the digastric muscle, the accessorius nerve, release of the medial neck block while sparing the facial vein. Then release of the neck block in levels IIb, III and IV while sparing the plexus branches. The internal jugular vein can be completely preserved. Now switch back to the left side and complete the neck dissection on this side while ligating and repositioning the internal jugular vein so that the metastasis in level II can be safely removed. Release the neck blocks IIb, III, IV and Va while sparing the plexus branches. The facial vein, which in this patient originates very far caudally from the internal jugular vein, can be preserved. The superior thyroid artery can also be preserved. Then remove the submandibular gland while sparing the lingual nerve and the lingual artery. Dissection of the omohyoid muscle and creation of an enoral access. Further tumor resection from the transoral side. The tumor can be retrieved en bloc and is suture-marked for frozen section. There is still carcinoma in situ on the posterior pharyngeal wall towards the medial side. Here, another large resection is performed and a final margin sample is taken. The final marginal sample R0, finally all R0. Lifting of the radialis graft by . The radialis graft is lifted 9 x 7 cm, from the left side. To do this, first mark the graft and the skin incision on the forearm up to the elbow. Then make a skin incision in the marked area, expose the venous plexus in the elbow area, then expose the brachioradialis muscle. Visualization of the medial antebrachial cutaneous nerve, then visualization of the superficial ramus, the radial nerve with its branches. Locate the radial artery, clamp the radial artery using a vascular clip for 10 minutes. The connected pulse oximeter shows a continuous 100 % oxygen saturation, so that the radial artery can finally be severed and stitched with an overlocking suture. The radialis graft is then lifted off the tendons while sparing the ulnar artery and the superficial ramus of the radial nerve. Dissect the pedicle cranially while clipping off the branches. A superficial and a deep vein are taken from the venous system with good confluence. Deposition of the radialis graft first in the venous limb, here it becomes apparent that only the deep vein conveys blood to the outside, the superficially prepared vessel does not convey blood and probably cannot be used for anastomosis. Now the arterial limb is removed and the radialis graft is fitted into the defect. This is very difficult as the defect is three-dimensional and sutures must be placed transcervically and the graft sutured in place. The rest is sutured in from the transoral side. This is again very difficult on the posterior pharyngeal wall in the cranial region, as the defect also extends very far towards the border of the nasopharynx due to the resection. Then preparation of the blood vessels. The superior thyroid artery is prepared as the artery and the facial vein as the vein. Now perform the arterial anastomosis in the usual manner with Ethilon 8-0 and then the venous anastomosis with a size 3.5 coupler. Insertion of a Redon drainage very far dorsally and two-layer wound closure on both sides. A Redon drain was also inserted on the right side. A tracheotomy was performed at the same time as the flap was lifted. Skin incision below the cricoid cartilage, separation of the fatty tissue, then exposure of the musculature and the linea alba, splitting of the musculature in the linea alba. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus, visualization of the anterior wall of the trachea. Entering the trachea between the 2nd and 3rd tracheal cartilage. No Björk flap is created and later reintubation to a tracheal cannula 9.0 without any problems. The split skin is also removed from the right thigh at the same time as the graft is lifted; this is then sutured to the forearm in the usual way and a dorsal forearm splint is fitted. The patient is ventilated in the intensive care unit, given antibiotics for at least 24 hours and the flap is checked according to the usual schedule. \ No newline at end of file diff --git a/258/InvasionFront_CD3_block16_x3_y5_patient258_0.json b/258/InvasionFront_CD3_block16_x3_y5_patient258_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eeeff273d0846d1b4f27146865f5359f368ef9a8 --- /dev/null +++ b/258/InvasionFront_CD3_block16_x3_y5_patient258_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11838.3, + "Centroid Y µm": 16860.5, + "Num Detections": 14496, + "Num Negative": 13596, + "Num Positive": 900, + "Positive %": 6.209, + "Num Positive per mm^2": 454.29 + } +} \ No newline at end of file diff --git a/258/InvasionFront_CD3_block16_x4_y5_patient258_1.json b/258/InvasionFront_CD3_block16_x4_y5_patient258_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6309390d62f3c7e7daad9b950ace5b94f14a79b0 --- /dev/null +++ b/258/InvasionFront_CD3_block16_x4_y5_patient258_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14973.2, + "Centroid Y µm": 17001.4, + "Num Detections": 16383, + "Num Negative": 13850, + "Num Positive": 2533, + "Positive %": 15.46, + "Num Positive per mm^2": 1116.9 + } +} \ No newline at end of file diff --git a/258/InvasionFront_CD8_block16_x3_y5_patient258_0.json b/258/InvasionFront_CD8_block16_x3_y5_patient258_0.json new file mode 100644 index 0000000000000000000000000000000000000000..93079992ca3da915aa8327abc3bebd6265ad74db --- /dev/null +++ b/258/InvasionFront_CD8_block16_x3_y5_patient258_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10903.5, + "Centroid Y µm": 12382.1, + "Num Detections": 11097, + "Num Negative": 10820, + "Num Positive": 277, + "Positive %": 2.496, + "Num Positive per mm^2": 191.22 + } +} \ No newline at end of file diff --git a/258/InvasionFront_CD8_block16_x4_y5_patient258_1.json b/258/InvasionFront_CD8_block16_x4_y5_patient258_1.json new file mode 100644 index 0000000000000000000000000000000000000000..17768379a914908e65ad850ee8a582d2f735d607 --- /dev/null +++ b/258/InvasionFront_CD8_block16_x4_y5_patient258_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14181.3, + "Centroid Y µm": 12563.9, + "Num Detections": 19057, + "Num Negative": 16982, + "Num Positive": 2075, + "Positive %": 10.89, + "Num Positive per mm^2": 890.54 + } +} \ No newline at end of file diff --git a/258/TumorCenter_CD3_block16_x4_y5_patient258_1.json b/258/TumorCenter_CD3_block16_x4_y5_patient258_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b488db2d9fbbbc7952580711e974c15945c3a0b --- /dev/null +++ b/258/TumorCenter_CD3_block16_x4_y5_patient258_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14217.5, + "Centroid Y µm": 13667.8, + "Num Detections": 81, + "Num Negative": 60, + "Num Positive": 21, + "Positive %": 25.93, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/258/TumorCenter_CD8_block16_x3_y5_patient258_0.json b/258/TumorCenter_CD8_block16_x3_y5_patient258_0.json new file mode 100644 index 0000000000000000000000000000000000000000..709cec589a7bb7c1c42f4e29747ee0e6d114ce58 --- /dev/null +++ b/258/TumorCenter_CD8_block16_x3_y5_patient258_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11094.1, + "Centroid Y µm": 13143.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/258/TumorCenter_CD8_block16_x4_y5_patient258_1.json b/258/TumorCenter_CD8_block16_x4_y5_patient258_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5112416d69fbfb4fb383e04f179b92c4a9e8f993 --- /dev/null +++ b/258/TumorCenter_CD8_block16_x4_y5_patient258_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 12968.1, + "Num Detections": 7986, + "Num Negative": 7141, + "Num Positive": 845, + "Positive %": 10.58, + "Num Positive per mm^2": 799.69 + } +} \ No newline at end of file diff --git a/258/history_text.txt b/258/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3ac1013f73c5f758994cea773249179e05653db7 --- /dev/null +++ b/258/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT2 tongue carcinoma on the right. The carcinoma at the base of the tongue showed deep ulceration, so that defect coverage using a radial flap was indicated. \ No newline at end of file diff --git a/258/icd_codes.txt b/258/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8ba22e0d242cd0b47cbb5e68e89bd0f11b79f6e4 --- /dev/null +++ b/258/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Zunge[C02.9 ] Neubildung bösartig Zunge sonstige[C02.8 ] \ No newline at end of file diff --git a/258/patient_clinical_data.json b/258/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..387bd1229380ce2fd428f1e78b3c7be52cdc252a --- /dev/null +++ b/258/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 40, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/258/patient_pathological_data.json b/258/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4c34236fa408058fe6da912a65dabeffca239fa8 --- /dev/null +++ b/258/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "258", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/258/surgery_description.txt b/258/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..745a95ffdaaeec4ec58caa9e8b5646b5cfe6c3cc --- /dev/null +++ b/258/surgery_description.txt @@ -0,0 +1 @@ +Hemi-glossectomy, Neck dissection, Radial flap coverage diff --git a/258/surgery_report.txt b/258/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f242460c352a27f43d7ab73d6b18705d94a861bd --- /dev/null +++ b/258/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Transoral tumor resection: insertion of rubber-reinforced wound blockers. Attachment of the tongue with a reining suture. Now a good overview of the tongue. The tumor is now resected far into the healthy tissue, at least 2 cm to all sides. This results in an almost complete hemi-glossectomy on the right, parts of the floor of the mouth as well as the sublingual gland and the sublingual/submandibular gland at the back are also removed. The lingual nerve is included in the resection. The tumor is thread-marked and sent for a frozen section. In the frozen section to all sides in healthy tissue, thus R0 resection. PEG insertion: Advancement of the flexible esophagoscope into the stomach. After creating a diaphanoscopy, placement of a 15 mm abdominal wall tube in a typical manner without complications. Fixation to the abdominal wall. After patho-histological confirmation of the R0 resection, transfer to neck dissection on both sides: skin disinfection both in the head/neck area on both sides as well as the left forearm and right groin. Injection of a total of 20 ml Ultracaine 1% with adrenaline in the area of both sides of the neck. Start of neck dissection on the left: Curved skin incision in a neck fold or along the sternocleidomastoid muscle. Subsequent exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, exposure of the digastric muscle and submandibular gland. The capsule is also removed in the caudal region. Subsequent exposure of the internal and external carotid artery, internal jugular vein and facial vein. Dissection and exposure, neurolysis and re-embedding of the hypoglossal nerve, accessorius nerve, vagus nerve, cervical artery and superficial branches of the cervical plexus. Successive clearing of levels II-IV. In the anterior neck area, the facial artery, the superior thyroid artery and the superior thyroid vein are exposed and preserved. Neck dissection on the right side: This is performed in the same way as on the left side. Level II-IV evacuation in the same way. In addition, level Ib excision including the submandibular gland and the sublingual gland. Both structures were resected as part of the tumor resection, here also with resection of the lingual nerve. Dissection and exposure, neurolysis and re-embedding of the hypoglossal nerve, accessorius nerve, vagus nerve and cervical nerve. The hypoglossal nerve is preserved here, as on the opposite side. Slightly enlarged lymph nodes on the right more than on the left, no significant signs of metastasis macroscopically. Removal of the forearm flap: marking of the skin island of approx. 5x8 cm. Apply a tourniquet. Cut around the skin island subfascially, incision up to the crook of the elbow in a curved manner. Exposure of the superficial venous system. Successive development of the radialis flap subfascially also from the radial side. Preservation of the antebrachial nerve if it does not run into the flap. Caudal clipping of veins. Exposure of the radial artery. This is clamped and supplied using 4.0 Prolene puncture ligatures, whereby a .................... suture to the skin area is also made in the flap area. The flap is then lifted subfascially under the vascular pedicle Outgoing vessels are clipped. Dissection up to the crook of the elbow. Exposure of the connection between the deep and superficial system. Outgoing veins are clipped. The artery is very thin. Therefore, dissection up to the division of the radial and ulnar arteries. Exposure of the confluence of the radial artery. Exposure of the cephalic vein. Now open the tourniquet. Good perfusion of the flap. Hemostasis again. Deposition of the flap on the cephalic vein, which is ligated cranially at the confluence of the radial vein, which is ligated cranially and shortly after the exit from the brachial artery, which is supplied by means of a clip and puncture ligatures. Subsequently good further perusion of the ulnar artery. Irrigation of the flap with heparin solution. Flap is voluminous overall due to the very thick subcutaneous layer. Subsequent insertion of the flap into the defect. Enlarge the tunnel again until it is three transverse fingers wide and one transverse finger high. The pedicle can be inserted through the tunnel into the soft tissues of the neck. Suture the flap, creating a slight tension through the thick subcutaneous layer. The flap is trimmed anteriorly in the area of the tip of the tongue. Complete defect coverage. The flap was partially sutured in place with sutures. Subsequent vascular anastomosis. Trimming of the superior thyroid artery and the radial artery. Suturing of these with 9.0 Ethilon. After opening the clamps, good arterial flow and good venous return. Then suture the cephalic vein at an outlet from the relatively thick facial vein. Select a 3 mm outlet for this purpose. The confluence of the radial vein is treated with clips. In the area of the facial vein, the cranial parts were ligated or supplied with clips. The distal superior thyroid artery was also supplied with clips. With good arterial flow, the alignment test shows good venous return. Subsequent careful hemostasis. Irrigation of the wound area on both sides. Wound closure in layers with insertion of a Redon drain on both sides. The wound in the forearm area was closed with full-thickness skin. A piece of full-thickness skin of the appropriate size was removed from the groin for this purpose. After mobilization of the skin edges and subcutaneous tissue, the groin is now closed in layers with minimal tension. The skin is closed using back-stitch sutures and a Redon drain is inserted. The forearm is closed in layers in the proximal area. The full-thickness skin from the groin is sutured into the defect. Complete closure of the defect. A Mepilex hydrogel dressing is then applied. Wölckchen compresses are then applied. The arm is then wrapped with absorbent cotton and a splint is fitted. Fixation of the arm to the Cramer splint with a loose bandage. Forearm always well supplied with blood after flap removal. Due to the situation of significant swelling in the tongue/oral cavity area, decision to perform a temporary tracheotomy: Kocher's collar incision. Dissection of the subcutaneous tissue up to the infrahyoid musculature. Division of these. Splitting of the very small thyroid isthmus after bipolar coagulation. Mobilization of the caudal skin. Subsequent creation of a small broad pedunculated Björk flap. Epithelialization of this in the typical manner with thibond sutures. Insertion of a 7 mm tracheal cannula. This is fixed with sutures. Slit compresses are applied to the inserted Redon drains, otherwise no further dressing. The site suitable for Doppler control was marked with a thread, right cervical. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue intraoperative antibiotics for approx. 1 week. Also continue heparin therapy, which was started intraoperatively at 500 I.U./hour. Flap control according to the scheme for 5 days. Nutrition via the inserted PEG tube for approx. 7-10 days. Final consultation with the anesthesiologist. \ No newline at end of file diff --git a/259/InvasionFront_CD3_block6_x1_y8_patient259_0.json b/259/InvasionFront_CD3_block6_x1_y8_patient259_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9a3436433a363e99248703852e9319aef9186238 --- /dev/null +++ b/259/InvasionFront_CD3_block6_x1_y8_patient259_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4197.8, + "Centroid Y µm": 20314.2, + "Num Detections": 24304, + "Num Negative": 23177, + "Num Positive": 1127, + "Positive %": 4.637, + "Num Positive per mm^2": 432.99 + } +} \ No newline at end of file diff --git a/259/InvasionFront_CD3_block6_x2_y8_patient259_1.json b/259/InvasionFront_CD3_block6_x2_y8_patient259_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f04497f5fbbfd38b0893ef3a7e570db66698d55 --- /dev/null +++ b/259/InvasionFront_CD3_block6_x2_y8_patient259_1.json @@ -0,0 +1,11 @@ +{ + 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