diff --git a/258/TumorCenter_CD3_block16_x3_y5_patient258_0.json b/258/TumorCenter_CD3_block16_x3_y5_patient258_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f6ceb6d4f26c4f49c01cbd88836605ce1cecb97 --- /dev/null +++ b/258/TumorCenter_CD3_block16_x3_y5_patient258_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11943.7, + "Centroid Y µm": 12693.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/258/ops_codes.txt b/258/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b95e1e255432ec52c49e42ddb8e68767010d57bf --- /dev/null +++ b/258/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion der Zunge durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] Transorale Resektion des Mundbodens mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-277.02 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Temporäre Tracheotomie[5-311.0 ] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Vollhaut Entnahmestelle Leisten- und Genitalregion[5-901.1c ] Vollhautdeckung großflächig Empfängerstelle Unterarm[5-902.68 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/259/InvasionFront_CD8_block6_x1_y6_patient259_0.json b/259/InvasionFront_CD8_block6_x1_y6_patient259_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d46a88b5cfbf3e2161fef526b1bae0de0163caba --- /dev/null +++ b/259/InvasionFront_CD8_block6_x1_y6_patient259_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4647.5, + "Centroid Y µm": 14542.3, + "Num Detections": 29200, + "Num Negative": 23679, + "Num Positive": 5521, + "Positive %": 18.91, + "Num Positive per mm^2": 1992.0 + } +} \ No newline at end of file diff --git a/259/InvasionFront_CD8_block6_x2_y6_patient259_1.json b/259/InvasionFront_CD8_block6_x2_y6_patient259_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f39d3c545ba1d18baee9e30421841fce9323b723 --- /dev/null +++ b/259/InvasionFront_CD8_block6_x2_y6_patient259_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7371.1, + "Centroid Y µm": 14617.3, + "Num Detections": 27658, + "Num Negative": 24135, + "Num Positive": 3523, + "Positive %": 12.74, + "Num Positive per mm^2": 1276.6 + } +} \ No newline at end of file diff --git a/259/TumorCenter_CD3_block6_x1_y6_patient259_0.json b/259/TumorCenter_CD3_block6_x1_y6_patient259_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5f69367253438bfa5319bdb26c6b85de1ac8b170 --- /dev/null +++ b/259/TumorCenter_CD3_block6_x1_y6_patient259_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 15416.8, + "Num Detections": 25672, + "Num Negative": 16067, + "Num Positive": 9605, + "Positive %": 37.41, + "Num Positive per mm^2": 3434.3 + } +} \ No newline at end of file diff --git a/259/TumorCenter_CD3_block6_x2_y6_patient259_1.json b/259/TumorCenter_CD3_block6_x2_y6_patient259_1.json new file mode 100644 index 0000000000000000000000000000000000000000..046ee0f4436a3d1104415d65fe3ee7f32a726eef --- /dev/null +++ b/259/TumorCenter_CD3_block6_x2_y6_patient259_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 15341.9, + "Num Detections": 23778, + "Num Negative": 19108, + "Num Positive": 4670, + "Positive %": 19.64, + "Num Positive per mm^2": 1725.8 + } +} \ No newline at end of file diff --git a/259/TumorCenter_CD8_block6_x1_y6_patient259_0.json b/259/TumorCenter_CD8_block6_x1_y6_patient259_0.json new file mode 100644 index 0000000000000000000000000000000000000000..90b8ce7295248d0a1cc94561a400d07d3cb35e2e --- /dev/null +++ b/259/TumorCenter_CD8_block6_x1_y6_patient259_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3698.0, + "Centroid Y µm": 15666.7, + "Num Detections": 30206, + "Num Negative": 26419, + "Num Positive": 3787, + "Positive %": 12.54, + "Num Positive per mm^2": 1318.6 + } +} \ No newline at end of file diff --git a/259/TumorCenter_CD8_block6_x2_y6_patient259_1.json b/259/TumorCenter_CD8_block6_x2_y6_patient259_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d74a30bd3caa2359145b59c11f3916907e8db7d6 --- /dev/null +++ b/259/TumorCenter_CD8_block6_x2_y6_patient259_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 15666.7, + "Num Detections": 24434, + "Num Negative": 21770, + "Num Positive": 2664, + "Positive %": 10.9, + "Num Positive per mm^2": 968.68 + } +} \ No newline at end of file diff --git a/259/history_text.txt b/259/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad7812dd796b30c1efd7a6ad292aaa47ee98f3c5 --- /dev/null +++ b/259/history_text.txt @@ -0,0 +1 @@ +Condition after panendoscopy and confirmed level II squamous cell carcinoma on the right. After performing a PET-CT, the right tonsil lobe is more luminous and on presentation at the tumor conference a tonsillectomy on the right side with frozen section and neck completion is recommended. In case of negative histology, completion of the CUP panendoscopy. Mirror findings revealed a hard palpable mass in the right tonsil lobe, mucosa otherwise without irritation. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/259/icd_codes.txt b/259/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..db2d5a86a2f56199b8dc155060586ba21f58dec9 --- /dev/null +++ b/259/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] Halslymphknotenmetastasen[C77.0 R] \ No newline at end of file diff --git a/259/ops_codes.txt b/259/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e29e2041cfb630419a67100ee727a17e3638dbf1 --- /dev/null +++ b/259/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] \ No newline at end of file diff --git a/259/patient_clinical_data.json b/259/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cec71c9541dedc3617b6196253818a2cb5b8044d --- /dev/null +++ b/259/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/259/patient_pathological_data.json b/259/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..648d4790200803a6a77bb7a08a154ffaa36a6493 --- /dev/null +++ b/259/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "259", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/259/surgery_description.txt b/259/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..771fe885af77fae980c671c59e73712a348fb60c --- /dev/null +++ b/259/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy, Completion of right neck dissection diff --git a/259/surgery_report.txt b/259/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..369bbb2524d1cb7a632b1c5c6c51d571a2bbd1e2 --- /dev/null +++ b/259/surgery_report.txt @@ -0,0 +1 @@ +After the team time-out, intubation by the anesthesia colleagues. Head positioning by the surgeon. Entering with the tonsil retractor. On palpation, the tonsil on the right is very hard. Therefore indication for tumor tonsillectomy on the right side. After medialization with forceps, resection of the right tonsil with sufficient safety distance and removal of a mucosal portion of the anterior and posterior palatal arch. Perform using the dissection technique, deep to the base of the tongue. Here, set down after focal bipolar coagulation. Taking marginal samples from the anterior palatal arch and the posterior palatal arch, as well as from the base of the wound and the base of the tongue, which are sent for histological assessment and frozen section. From the frozen section diagnosis, the tumor specimen is R0-resected and the marginal specimens are also clear on all sides. Transition to neck dissection on the right side. After injection of 10 ml Ultracaine with Suprarenin, sterile draping. Additional application of a skin film and marking of the landmarks and the incision in extension of the old scar. Incision and dissection up to the platysma. Exposure of the anterior margin of the sternocleidomastoid. The tissue is heavily scarred, especially cranially, so start on the caudal side in level IV. First, expose the omohyoid muscle as the border of the neck dissection. Dissection of the anterior part of the sternocleidomastoid and dissection of the internal jugular vein into the caudal scarred tissue. Detachment of the vein and removal of the neck preparation from caudal to cranial, by detaching the scarred cords and identification of the already exposed accessorius nerve. The hypoglossal nerve can also be seen on the lower edge of the digaster venter anterior muscle. Exposure of the capsule of the submandibular glans and the plexus branches. Now resection of scar tissue and the neck preparation with evacuation of regions Ib, IIa, IIb, III, IV and Va and removal of the same while protecting the exposed nerves. Re-inspection of the wound. Irrigation with H2O2 and Ringer. Insertion of a miniredon. There is no evidence of further bleeding. Two-layer wound closure in the usual manner. Re-inspection of the tonsillar lobe on the right. There is no evidence of further bleeding and the procedure is completed without complications. \ No newline at end of file diff --git a/260/InvasionFront_CD3_block14_x1_y6_patient260_0.json b/260/InvasionFront_CD3_block14_x1_y6_patient260_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0670b2b9426f258d5df9147087f4c74f65141217 --- /dev/null +++ b/260/InvasionFront_CD3_block14_x1_y6_patient260_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4572.6, + "Centroid Y µm": 18540.2, + "Num Detections": 17823, + "Num Negative": 15296, + "Num Positive": 2527, + "Positive %": 14.18, + "Num Positive per mm^2": 1246.3 + } +} \ No newline at end of file diff --git a/260/InvasionFront_CD3_block14_x2_y6_patient260_1.json b/260/InvasionFront_CD3_block14_x2_y6_patient260_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ee43e45d05c9ebd838506bdc173799458776d866 --- /dev/null +++ b/260/InvasionFront_CD3_block14_x2_y6_patient260_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7146.2, + "Centroid Y µm": 18690.1, + "Num Detections": 16907, + "Num Negative": 15573, + "Num Positive": 1334, + "Positive %": 7.89, + "Num Positive per mm^2": 669.17 + } +} \ No newline at end of file diff --git a/260/InvasionFront_CD8_block14_x1_y6_patient260_0.json b/260/InvasionFront_CD8_block14_x1_y6_patient260_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6aecdab55db5b1bf09297bdc8987e2278721ae7f --- /dev/null +++ b/260/InvasionFront_CD8_block14_x1_y6_patient260_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4772.5, + "Centroid Y µm": 14492.3, + "Num Detections": 17158, + "Num Negative": 14081, + "Num Positive": 3077, + "Positive %": 17.93, + "Num Positive per mm^2": 1556.9 + } +} \ No newline at end of file diff --git a/260/InvasionFront_CD8_block14_x2_y6_patient260_1.json b/260/InvasionFront_CD8_block14_x2_y6_patient260_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f4edfef0ec0da1f05701f8ad90ed5a1edd16c5f2 --- /dev/null +++ b/260/InvasionFront_CD8_block14_x2_y6_patient260_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7221.2, + "Centroid Y µm": 14617.3, + "Num Detections": 16501, + "Num Negative": 14910, + "Num Positive": 1591, + "Positive %": 9.642, + "Num Positive per mm^2": 808.76 + } +} \ No newline at end of file diff --git a/260/TumorCenter_CD3_block14_x1_y6_patient260_0.json b/260/TumorCenter_CD3_block14_x1_y6_patient260_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9098e288af3b799982bd12c069ab791237dac79f --- /dev/null +++ b/260/TumorCenter_CD3_block14_x1_y6_patient260_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4297.7, + "Centroid Y µm": 14867.1, + "Num Detections": 15619, + "Num Negative": 14044, + "Num Positive": 1575, + "Positive %": 10.08, + "Num Positive per mm^2": 785.75 + } +} \ No newline at end of file diff --git a/260/TumorCenter_CD3_block14_x2_y6_patient260_1.json b/260/TumorCenter_CD3_block14_x2_y6_patient260_1.json new file mode 100644 index 0000000000000000000000000000000000000000..84bfea01bd83c87446287ac884d06baf2ce34bcf --- /dev/null +++ b/260/TumorCenter_CD3_block14_x2_y6_patient260_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6846.4, + "Centroid Y µm": 15067.0, + "Num Detections": 16353, + "Num Negative": 14772, + "Num Positive": 1581, + "Positive %": 9.668, + "Num Positive per mm^2": 760.53 + } +} \ No newline at end of file diff --git a/260/TumorCenter_CD8_block14_x1_y6_patient260_0.json b/260/TumorCenter_CD8_block14_x1_y6_patient260_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7bc50c321c86cc334a652dc70360824e0061067a --- /dev/null +++ b/260/TumorCenter_CD8_block14_x1_y6_patient260_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 15516.8, + "Num Detections": 17604, + "Num Negative": 16390, + "Num Positive": 1214, + "Positive %": 6.896, + "Num Positive per mm^2": 605.76 + } +} \ No newline at end of file diff --git a/260/TumorCenter_CD8_block14_x2_y6_patient260_1.json b/260/TumorCenter_CD8_block14_x2_y6_patient260_1.json new file mode 100644 index 0000000000000000000000000000000000000000..11cea877f0ce6d9976e9c7d9290203c27d9feb0d --- /dev/null +++ b/260/TumorCenter_CD8_block14_x2_y6_patient260_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 15541.8, + "Num Detections": 18687, + "Num Negative": 17480, + "Num Positive": 1207, + "Positive %": 6.459, + "Num Positive per mm^2": 571.65 + } +} \ No newline at end of file diff --git a/260/history_text.txt b/260/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a5e122ecc0fd20f23521b694ef80ea4ddfbbb524 --- /dev/null +++ b/260/history_text.txt @@ -0,0 +1 @@ +Patient with histologically proven cT4a cN1 G3 supraglottic laryngeal carcinoma with infiltration of the thyroid cartilage and the arytenoid cartilage on the right side. Now indication for the above-mentioned measures. \ No newline at end of file diff --git a/260/icd_codes.txt b/260/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7af9d48e72358f0d6d1087f5348fc77085d2054 --- /dev/null +++ b/260/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 R] \ No newline at end of file diff --git a/260/ops_codes.txt b/260/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..64d2bb42dd125bc151d561a98f61095108c55621 --- /dev/null +++ b/260/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Krikopharyngeale Myotomie[5-290.x ] \ No newline at end of file diff --git a/260/patient_clinical_data.json b/260/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ac527d2cd0949e95e29c6727199f0620558921fa --- /dev/null +++ b/260/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/260/patient_pathological_data.json b/260/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..460428e3d413389072598bebe8f07fec56e86f28 --- /dev/null +++ b/260/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "260", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/260/surgery_description.txt b/260/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f298835c826831eb3434b6541b2a551e91378669 --- /dev/null +++ b/260/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Placement of nasogastric tube, Placement of voice prosthesis diff --git a/260/surgery_report.txt b/260/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..057d445471704cb898e5dddcceb07d43fd6d0aa2 --- /dev/null +++ b/260/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia and ventilation of the patient via the existing tracheostoma. Re-intubation of the patient onto a laryngectomy tube and subsequent performance of a laryngoscopy using a Kleinsasser C-tube. This revealed an exophytic, contact-vulnerable mass covering the entire supraglottis on the right side with clear infiltration of the interaryngeal region and the arytenoid region on the right side and infiltration of the vocal fold on the right side. The rest of the endolarynx and the hypopharynx were unremarkable. Subsequently, a nasogastric feeding tube was inserted under visualization in a typical manner. A PEG insertion was deliberately avoided in this session due to the condition after the previous operation and the expected scarred conditions in the abdomen. This should then be inserted by the surgical colleagues. Local anesthesia is then applied cervically ........... submedially. Skin ablation and sterile draping. Skin incision. Dissection of the subcutaneous tissue and the platysma and formation of a subplatysmal apron flap in the typical manner. Exposure and transection of the prelaryngeal muscles in the midline. Exposure of the thyroidithm, which is still present. Dissecting it in the midline. Exposure of the anterior wall of the trachea. Subsequent exposure of the external jugular vein on both sides. Dissection along the anterior border of the sternocleidomastoid muscle on the right side. Exposure and sparing of the auricular nerve. Exposure of the digaster muscle (venter posterior). Exposure of the accessorius nerve and the omohyoid muscle. Exposure of the internal jugular vein, the accessorius nerve and the common carotid artery. Dissection along the cervical vascular sheath from caudal to cranial up to the digaster muscle. Successive removal of the posterior and anterior neck preparation while sparing the above-mentioned structures and the plexus branches. Several suspicious lymph nodes in regions III and IV, which were also removed in the neck preparation. Repositioning of the patient on the left side to perform the neck dissection. Dissection along the anterior edge of the sternocleidomastoid muscle. Exposure and protection of the auricularis magnus nerve. Exposure and ligation of the external jugular vein. Exposure of the accessorius nerve, the posterior venter of the digaster muscle and the omohyoid muscle. Exposure of the internal jugular vein. Exposure of the vagus nerve and the common carotid artery. Dissection along the cervical vascular sheath from caudal to cranial. Successive removal of the posterior and anterior neck preparation while protecting the above-mentioned structures and the plexus branches. Dry conditions on both sides. Subsequent skeletonization of the hyoid bone. Dissection of the infrahyoid musculature. A large part of the sternohyoid muscle and the sternothyroid muscle at the level of the thyroid cartilage is removed with the tumor preparation. Subsequent exposure of the thyroid cartilage. Skeletonization of the same. Scalpel incision along the posterior edge of the thyroid cartilage on both sides and removal of the muscle fibers of the constrictor pharyngis medius muscle on both sides. Sparing of the wall of the piriform sinus on both sides. Subsequent dissection of the hyoid bone from the suprahyoid soft tissue. Dissection in this region and exposure of the free edge of the epiglottis and pharyngotomy. Opening of the pharyngeal lumen. Incision along the lateral edges of the epiglottis and along the aryepiglottic folds on both sides. Strict care is taken to preserve the mucosa of the piriform sinus on both sides as much as possible. Joining of both vertical incisions in the postcricoid area. Separation of the mucosa of the hypopharynx from the laryngeal skeleton and further dissection between the hypopharynx as well as the esophagus and the posterior wall of the trachea. Repeated hemostasis using bipolar coagulation. Deposition of the preparation at the level of the third tracheal cartilage clasp. Hemostasis using bipolar coagulation. Three marginal samples were taken (right piriform sinus, anterior and posterior tracheal margin). All three samples were found to be tumor-free by the pathology colleagues. Subsequently insertion of a size 8 Provox prosthesis in the typical manner. Perform a careful cricopharyngeal myotomy over a distance of 3 cm laterally on the left. Resection of the caudal end of the sternocleidomastoid muscle on both sides. Three-layer pharyngeal suture. Reinforcement of the pharyngeal suture using Tachosil. Suture adaptation of the prelaryngeal musculature. Knockback of the subplatysmal apron flap. Tracheostomy sutures. Two-layer wound closure. Application of a pressure dressing. Re-intubation of the patient to a size 8 tracheostomy tube. Completion of the procedure without complications. Conclusion: Laryngectomy, modified radical neck dissection on both sides, insertion of a size 8 Provox prosthesis, insertion of a nasogastric feeding tube. Please present the patient to our interdisciplinary tumor conference as soon as possible. If adjuvant radiochemotherapy is indicated, a PEG should be inserted by our surgical colleagues due to the patient's condition following previous surgery. \ No newline at end of file diff --git a/261/InvasionFront_CD3_block16_x3_y9_patient261_0.json b/261/InvasionFront_CD3_block16_x3_y9_patient261_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d6bc24d58ee42adf59a98d98c7f4b1f78ce2466b --- /dev/null +++ b/261/InvasionFront_CD3_block16_x3_y9_patient261_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11679.7, + "Centroid Y µm": 26833.7, + "Num Detections": 12866, + "Num Negative": 11742, + "Num Positive": 1124, + "Positive %": 8.736, + "Num Positive per mm^2": 525.83 + } +} \ No newline at end of file diff --git a/261/InvasionFront_CD3_block16_x4_y9_patient261_1.json b/261/InvasionFront_CD3_block16_x4_y9_patient261_1.json new file mode 100644 index 0000000000000000000000000000000000000000..868ff9f5d8713ac348c9b207ed15ededf797333a --- /dev/null +++ b/261/InvasionFront_CD3_block16_x4_y9_patient261_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14303.6, + "Centroid Y µm": 26957.0, + "Num Detections": 16612, + "Num Negative": 14886, + "Num Positive": 1726, + "Positive %": 10.39, + "Num Positive per mm^2": 773.9 + } +} \ No newline at end of file diff --git a/261/InvasionFront_CD8_block16_x3_y9_patient261_0.json b/261/InvasionFront_CD8_block16_x3_y9_patient261_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dc3ffaa523887d3256285804729d2ee7b8a0eadb --- /dev/null +++ b/261/InvasionFront_CD8_block16_x3_y9_patient261_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10671.8, + "Centroid Y µm": 22064.7, + "Num Detections": 14156, + "Num Negative": 13436, + "Num Positive": 720, + "Positive %": 5.086, + "Num Positive per mm^2": 367.42 + } +} \ No newline at end of file diff --git a/261/InvasionFront_CD8_block16_x4_y9_patient261_1.json b/261/InvasionFront_CD8_block16_x4_y9_patient261_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bbac624067a44b5025f86bc31124158efa95fbfb --- /dev/null +++ b/261/InvasionFront_CD8_block16_x4_y9_patient261_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13337.3, + "Centroid Y µm": 22154.9, + "Num Detections": 17895, + "Num Negative": 16671, + "Num Positive": 1224, + "Positive %": 6.84, + "Num Positive per mm^2": 553.36 + } +} \ No newline at end of file diff --git a/261/TumorCenter_CD3_block16_x3_y9_patient261_0.json b/261/TumorCenter_CD3_block16_x3_y9_patient261_0.json new file mode 100644 index 0000000000000000000000000000000000000000..30c2bb7afab2c2e309c421e35aa71d11993811df --- /dev/null +++ b/261/TumorCenter_CD3_block16_x3_y9_patient261_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 23037.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/261/TumorCenter_CD3_block16_x4_y9_patient261_1.json b/261/TumorCenter_CD3_block16_x4_y9_patient261_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f2351704f5eff150bf992f11b53c4d052b38fb2a --- /dev/null +++ b/261/TumorCenter_CD3_block16_x4_y9_patient261_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13967.6, + "Centroid Y µm": 23112.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/261/TumorCenter_CD8_block16_x3_y9_patient261_0.json b/261/TumorCenter_CD8_block16_x3_y9_patient261_0.json new file mode 100644 index 0000000000000000000000000000000000000000..82b0fd35885b62436eb708edcc5ba5b154b532e0 --- /dev/null +++ b/261/TumorCenter_CD8_block16_x3_y9_patient261_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 22962.8, + "Num Detections": 12260, + "Num Negative": 11612, + "Num Positive": 648, + "Positive %": 5.285, + "Num Positive per mm^2": 404.92 + } +} \ No newline at end of file diff --git a/261/TumorCenter_CD8_block16_x4_y9_patient261_1.json b/261/TumorCenter_CD8_block16_x4_y9_patient261_1.json new file mode 100644 index 0000000000000000000000000000000000000000..43b643d89826e5a06e7ef117dd228ff6a0f726a6 --- /dev/null +++ b/261/TumorCenter_CD8_block16_x4_y9_patient261_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 22987.8, + "Num Detections": 5887, + "Num Negative": 5689, + "Num Positive": 198, + "Positive %": 3.363, + "Num Positive per mm^2": 256.5 + } +} \ No newline at end of file diff --git a/261/history_text.txt b/261/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c7073aadd09106f6bae3e70b10890e72d26fd47e --- /dev/null +++ b/261/history_text.txt @@ -0,0 +1 @@ +In the patient, a progressive mass on the right edge of the tongue was confirmed externally as a G1 differentiated squamous cell carcinoma. Now indication for exclusion of a second malignancy and for enoral tumor resection. Sonography revealed a cN0 neck status. \ No newline at end of file diff --git a/261/icd_codes.txt b/261/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b726963807f048843213f2656edbce103649d7e --- /dev/null +++ b/261/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zunge, nicht näher bezeichnet[C02.9 ] \ No newline at end of file diff --git a/261/ops_codes.txt b/261/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..92b39251cc282f95e6e3536c3845b4bcf1c173ef --- /dev/null +++ b/261/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit flexiblem Instrument ohne weitere Maßnahmen[1-620.00 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Lokale Exzision am Pharynx[5-292.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/261/patient_clinical_data.json b/261/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b956b6f0ec1729e2a40270ae4488056f2eb93d64 --- /dev/null +++ b/261/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 75, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 47, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/261/patient_pathological_data.json b/261/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1458c84f0d075413bc02ec63d02b696adbe33b26 --- /dev/null +++ b/261/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "261", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 6.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "1.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/261/surgery_description.txt b/261/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..75c9bf7f758ab6a630ef73c278517ca376c365a3 --- /dev/null +++ b/261/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy diff --git a/261/surgery_report.txt b/261/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f3e8c4422617d22a737424e497a7d038173036b6 --- /dev/null +++ b/261/surgery_report.txt @@ -0,0 +1 @@ +After induction and deepening of the anesthesia by the anesthesia colleagues, perform a rigid tracheoscopy under laryngoscopic control. Easy screening. The trachea is clear and inconspicuous up to the carina, as is the endolarynx including the subglottic region. Problem-free intubation by the surgeon and positioning of the patient. First, flexible esophagogastroscopy was carried out: the gastroscope was inserted under laryngoscopic control. Easy visualization of the stomach. This is inconspicuous and clear. Inspection of the oesophagus on reflection. Here there are ubiquitous small roundish, slightly papillomatous raised changes without suspicious conditions. No further measures required. Otherwise, the esophageal mucosa is free of irritation. Now enter with the small bore tube after inspection of the inconspicuous oral vestibule under dental protection. Inspection of the oral cavity. On the right side, in the area of the middle and transition to the posterior third of the right edge of the tongue, there is an exophytic, slightly exulcerated mass, easily delimited by palpation, approx. 2.5 cm in diameter with an estimated palpatory penetration depth of approx. ˝ cm. On the surface, there are whitish mucosal changes in the area surrounding the tumor, which are not primarily suspicious. The lateral floor of the mouth and the glossotonsillar groove are clear. On further examination, however, there is a circumscribed tear in the right glossotonsillar groove. In dry conditions, no further action is required here. The rest of the tongue is palpatorily and macroscopically free, as are the soft palate, the tonsil region and the base of the tongue. Inspection of the vallecula. A cystic change measuring approx. 1 cm on the median right side is seen here, macroscopically corresponding to a vallecula cyst. This is removed in toto with a double spoon and scissors in the sense of an excisional biopsy. Careful hemostasis using a suprarenal swab and no further measures in dry conditions. The epiglottis is clear. Inspection of the hypopharynx, which can be easily inserted into the tips of the piriform sinus and the esophageal opening and is clear. Adjustment of the endolarynx. Confirmation of inconspicuous findings with a normal glottic plane and inconspicuous supraglottic region. Transoral resection is now performed if the carcinoma is externally confirmed. The open mouth retractor is inserted for this purpose. Snare the free edge of the tongue. Cut around the lesion with a safety margin of approx. 1.5 cm. Also select a macroscopic safety margin of 1.5 cm in depth. Careful preparation with bipolar coagulation and monopolar dissection. The resectate is thread-marked for urgent definitive histology. Due to the whitish, leaking mucosal changes, a covering final margin sample is taken in the area of the free edge of the tongue and the floor of the mouth, which is also thread-marked for urgent histology. Macroscopically wide in sano resection. Meticulous hemostasis. Then adaptation of the wound edges with 3.0 Vicryl if there is a clear defect. Finally, intact conditions and with dry enoral conditions and slender tongue, completion of the procedure without any indication of complications. Conclusion: Macroscopic in sano resection of a cT2 tongue margin carcinoma on the right. If the R0 situation is confirmed histologically, a neck dissection should be performed depending on the histology; in the case of G1 differentiation, a neck dissection may not be necessary, depending on ............, otherwise a selective neck dissection on the right should be performed from an infiltration depth of 4 mm. \ No newline at end of file diff --git a/262/InvasionFront_CD3_block21_x1_y7_patient262_0.json b/262/InvasionFront_CD3_block21_x1_y7_patient262_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08fd80f2a60d98434433afef692ac5a7a181b18a --- /dev/null +++ b/262/InvasionFront_CD3_block21_x1_y7_patient262_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5921.9, + "Centroid Y µm": 27535.4, + "Num Detections": 19814, + "Num Negative": 18371, + "Num Positive": 1443, + "Positive %": 7.283, + "Num Positive per mm^2": 701.84 + } +} \ No newline at end of file diff --git a/262/InvasionFront_CD3_block21_x2_y7_patient262_1.json b/262/InvasionFront_CD3_block21_x2_y7_patient262_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4dc34e91d468ac7635392a2759ccd8cbb05e2084 --- /dev/null +++ b/262/InvasionFront_CD3_block21_x2_y7_patient262_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8570.5, + "Centroid Y µm": 27810.3, + "Num Detections": 19411, + "Num Negative": 17174, + "Num Positive": 2237, + "Positive %": 11.52, + "Num Positive per mm^2": 1067.0 + } +} \ No newline at end of file diff --git a/262/InvasionFront_CD8_block21_x1_y7_patient262_0.json b/262/InvasionFront_CD8_block21_x1_y7_patient262_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c5d4ecc564afb57e9c3ac30e01a61562498b3ce3 --- /dev/null +++ b/262/InvasionFront_CD8_block21_x1_y7_patient262_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3423.2, + "Centroid Y µm": 17215.9, + "Num Detections": 17166, + "Num Negative": 15889, + "Num Positive": 1277, + "Positive %": 7.439, + "Num Positive per mm^2": 652.74 + } +} \ No newline at end of file diff --git a/262/InvasionFront_CD8_block21_x2_y7_patient262_1.json b/262/InvasionFront_CD8_block21_x2_y7_patient262_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d48dee8fb29b1325d62e7000baa5d1aab23383ab --- /dev/null +++ b/262/InvasionFront_CD8_block21_x2_y7_patient262_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6021.8, + "Centroid Y µm": 17290.8, + "Num Detections": 18695, + "Num Negative": 15803, + "Num Positive": 2892, + "Positive %": 15.47, + "Num Positive per mm^2": 1400.2 + } +} \ No newline at end of file diff --git a/262/TumorCenter_CD3_block21_x1_y7_patient262_0.json b/262/TumorCenter_CD3_block21_x1_y7_patient262_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9b9498347b7b63d4eb357ac8f93562ea999daac6 --- /dev/null +++ b/262/TumorCenter_CD3_block21_x1_y7_patient262_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.1, + "Centroid Y µm": 20364.2, + "Num Detections": 14241, + "Num Negative": 12781, + "Num Positive": 1460, + "Positive %": 10.25, + "Num Positive per mm^2": 796.27 + } +} \ No newline at end of file diff --git a/262/TumorCenter_CD3_block21_x2_y7_patient262_1.json b/262/TumorCenter_CD3_block21_x2_y7_patient262_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7cd0b4f81dcffe4817c52c2724b76a620dfef892 --- /dev/null +++ b/262/TumorCenter_CD3_block21_x2_y7_patient262_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 20214.3, + "Num Detections": 18304, + "Num Negative": 17421, + "Num Positive": 883, + "Positive %": 4.824, + "Num Positive per mm^2": 435.74 + } +} \ No newline at end of file diff --git a/262/TumorCenter_CD8_block21_x1_y7_patient262_0.json b/262/TumorCenter_CD8_block21_x1_y7_patient262_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac74e0accb0232b167689300bcaf80643b6e9a84 --- /dev/null +++ b/262/TumorCenter_CD8_block21_x1_y7_patient262_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5946.9, + "Centroid Y µm": 32133.0, + "Num Detections": 14401, + "Num Negative": 12666, + "Num Positive": 1735, + "Positive %": 12.05, + "Num Positive per mm^2": 890.89 + } +} \ No newline at end of file diff --git a/262/TumorCenter_CD8_block21_x2_y7_patient262_1.json b/262/TumorCenter_CD8_block21_x2_y7_patient262_1.json new file mode 100644 index 0000000000000000000000000000000000000000..45647c8a77cc1accd3f7c9ddfc2ae168f6f87234 --- /dev/null +++ b/262/TumorCenter_CD8_block21_x2_y7_patient262_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8520.5, + "Centroid Y µm": 32133.0, + "Num Detections": 16895, + "Num Negative": 16148, + "Num Positive": 747, + "Positive %": 4.421, + "Num Positive per mm^2": 378.06 + } +} \ No newline at end of file diff --git a/262/history_text.txt b/262/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..de70d05475885b9e272ceadf53fb740fe3fd5e74 --- /dev/null +++ b/262/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed laryngeal carcinoma with a breakthrough through the cranial cartilage. The above-mentioned procedure should therefore be performed. \ No newline at end of file diff --git a/262/icd_codes.txt b/262/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc6fd121dc40d22b6fb46d31a947332bc01b0c9d --- /dev/null +++ b/262/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/262/ops_codes.txt b/262/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d2583b03539a0c60138b279ac7d67f82dd63eda --- /dev/null +++ b/262/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie: Einfache Laryngektomie: Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal: 6 Regionen[5-403.12 R] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 6 Regionen[5-403.22 L] \ No newline at end of file diff --git a/262/patient_clinical_data.json b/262/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c689ebaa14c521608b8e41ee93313304cdb7d133 --- /dev/null +++ b/262/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 49, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/262/patient_pathological_data.json b/262/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3e6a336b0cb09e7833eb9e8ea404dab65ca1924b --- /dev/null +++ b/262/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "262", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN2a", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/262/surgery_description.txt b/262/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..84c980c0664994aed4e4799c90a0e5e3b5e95340 --- /dev/null +++ b/262/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Radical bilateral neck dissection diff --git a/262/surgery_report.txt b/262/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f609084d048a94c14b54beab6af7c11be59775ce --- /dev/null +++ b/262/surgery_report.txt @@ -0,0 +1 @@ +First alcohol disinfection. Application of local anesthesia. Apron-like skin incision. Subcutaneous preparation. Neck dissection is then performed on the left side. To do this, first expose the internal jugular vein, the accessorius nerve, the digastric muscle, the vagus nerve, the external and internal carotid artery. Then successive development of the lateral neck preparation while sparing the above-mentioned structures. Development of the medial neck preparation, also sparing the above-mentioned structures. Now repositioning for neck dissection on the right side. Infiltration, at least of the internal jugular vein. For this reason, the cranial and caudal ends of the internal jugular vein are exposed first. This is ligated. Then visualization of the accessorius nerve and the digastric muscle. Here it is already suspected that the accessor nerve is infiltrated by a large lymph node metastasis. This also infiltrates the sternocleidomastoid muscle. The tumor block is now dissected laterally from the medial side along the external and internal carotid artery. During further dissection and visualization of the vagus nerve, this is also infiltrated at approximately the level of the carotid bifurcation and is therefore included. The tumor or neck preparation is then developed and removed, taking parts of the sternocleidomastoid muscle with it and partially taking the omohyoid muscle with it. Careful hemostasis, left and right. Now development of the larynx preparation. To do this, first expose the hyoid bone and the thyroid cartilage. Separation of the pharyngeal muscles from the thyroid cartilage on both sides. A tracheotomy is then performed beforehand. This involves cutting through the thyroid isthmus. This is stitched and then a tracheotomy is performed between the 2nd and 3rd tracheal clasp. First incision of the caudal skin flap. Further development of the LE preparation. For this purpose, release of the piriform sinus on both sides. Then release the epiglottis at the free edge of the epiglottis. Then entering the pharyngeal tube and successive excision of the laryngeal preparation along the aryepiglottic fold. Incision united posteriorly postcricoidally. Detachment of the postcricoid mucosa, which is not affected by the cricoid cartilage plate. Further detachment of the laryngeal preparation. Separation in the area of the trachea and removal of the entire preparation for frozen section diagnostics. The edges of the incision are found to be tumor-free. Now rinse thoroughly. Cut through the pharyngeal muscles or the esophageal sphincter. Insertion of a Provox prosthesis 4 to 5 mm above the edge of the tracheal incision. This is successful without any problems. Then multi-layered, inverting pharyngeal suture. Readaptation of the infrahyoid muscles at the hyoid bone after subtle hemostasis has been performed. Now suturing of the tracheostoma and skin after insertion of 2 Redon drains, one on the left and one on the right. Multi-layer wound closure. Completion of the procedure. \ No newline at end of file diff --git a/263/InvasionFront_CD3_block18_x3_y12_patient263_0.json b/263/InvasionFront_CD3_block18_x3_y12_patient263_0.json new file mode 100644 index 0000000000000000000000000000000000000000..85e3797960f8476d6447cbf29ed3dd1528773b87 --- /dev/null +++ b/263/InvasionFront_CD3_block18_x3_y12_patient263_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10444.5, + "Centroid Y µm": 34656.6, + "Num Detections": 19452, + "Num Negative": 18915, + "Num Positive": 537, + "Positive %": 2.761, + "Num Positive per mm^2": 236.83 + } +} \ No newline at end of file diff --git a/263/InvasionFront_CD3_block18_x4_y12_patient263_1.json b/263/InvasionFront_CD3_block18_x4_y12_patient263_1.json new file mode 100644 index 0000000000000000000000000000000000000000..40dae50c2f6045f86cac97eb15dca72032f60fa3 --- /dev/null +++ b/263/InvasionFront_CD3_block18_x4_y12_patient263_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13043.1, + "Centroid Y µm": 34856.5, + "Num Detections": 20895, + "Num Negative": 20317, + "Num Positive": 578, + "Positive %": 2.766, + "Num Positive per mm^2": 242.32 + } +} \ No newline at end of file diff --git a/263/InvasionFront_CD8_block18_x3_y12_patient263_0.json b/263/InvasionFront_CD8_block18_x3_y12_patient263_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a7227039b6d78768898f30556a315ecaeec7d91 --- /dev/null +++ b/263/InvasionFront_CD8_block18_x3_y12_patient263_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11319.0, + "Centroid Y µm": 37055.4, + "Num Detections": 18310, + "Num Negative": 18290, + "Num Positive": 20, + "Positive %": 0.1092, + "Num Positive per mm^2": 8.822 + } +} \ No newline at end of file diff --git a/263/InvasionFront_CD8_block18_x4_y12_patient263_1.json b/263/InvasionFront_CD8_block18_x4_y12_patient263_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1e05d5682e4d4dffbd4912db1071e86cfc865109 --- /dev/null +++ b/263/InvasionFront_CD8_block18_x4_y12_patient263_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 37130.3, + "Num Detections": 24301, + "Num Negative": 24257, + "Num Positive": 44, + "Positive %": 0.1811, + "Num Positive per mm^2": 17.21 + } +} \ No newline at end of file diff --git a/263/TumorCenter_CD3_block18_x3_y12_patient263_0.json b/263/TumorCenter_CD3_block18_x3_y12_patient263_0.json new file mode 100644 index 0000000000000000000000000000000000000000..86dddc1f22ed034f528035b05bae0cb1514fb06d --- /dev/null +++ b/263/TumorCenter_CD3_block18_x3_y12_patient263_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10416.3, + "Centroid Y µm": 29102.8, + "Num Detections": 10656, + "Num Negative": 10556, + "Num Positive": 100, + "Positive %": 0.9384, + "Num Positive per mm^2": 43.51 + } +} \ No newline at end of file diff --git a/263/TumorCenter_CD3_block18_x4_y12_patient263_1.json b/263/TumorCenter_CD3_block18_x4_y12_patient263_1.json new file mode 100644 index 0000000000000000000000000000000000000000..28aca15ef32693178198ad53ad4940531418b7fb --- /dev/null +++ b/263/TumorCenter_CD3_block18_x4_y12_patient263_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12991.7, + "Centroid Y µm": 29160.2, + "Num Detections": 8269, + "Num Negative": 8023, + "Num Positive": 246, + "Positive %": 2.975, + "Num Positive per mm^2": 99.85 + } +} \ No newline at end of file diff --git a/263/TumorCenter_CD8_block18_x3_y12_patient263_0.json b/263/TumorCenter_CD8_block18_x3_y12_patient263_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0695c77d028c9f2c9702fb4a82396e9d4b8d8ee6 --- /dev/null +++ b/263/TumorCenter_CD8_block18_x3_y12_patient263_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10544.4, + "Centroid Y µm": 30009.1, + "Num Detections": 19863, + "Num Negative": 19841, + "Num Positive": 22, + "Positive %": 0.1108, + "Num Positive per mm^2": 9.001 + } +} \ No newline at end of file diff --git a/263/TumorCenter_CD8_block18_x4_y12_patient263_1.json b/263/TumorCenter_CD8_block18_x4_y12_patient263_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ef45656d596265c2fd07742b9aa11157e52c9b7d --- /dev/null +++ b/263/TumorCenter_CD8_block18_x4_y12_patient263_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13043.1, + "Centroid Y µm": 29959.1, + "Num Detections": 23149, + "Num Negative": 23134, + "Num Positive": 15, + "Positive %": 0.0648, + "Num Positive per mm^2": 5.807 + } +} \ No newline at end of file diff --git a/263/history_text.txt b/263/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2fcbb663d8a17041760e4787fe492862f1eff74d --- /dev/null +++ b/263/history_text.txt @@ -0,0 +1 @@ +After panendoscopy with test biopsy, the patient had a histologically confirmed glottic carcinoma of at least cT2 cN0 on the right side with extension to the subglottic, anterior commissure and morgue sinus. This was confirmed histologically. In addition, there is a simultaneous histologically confirmed hilar bronchial carcinoma. B-scan ultrasonography revealed a cN0 neck status. A CT scan was performed and a cT2-3 glottic carcinoma on the right was suspected, with no definite evidence of cartilage infiltration. The patient was informed in detail about the treatment options, surgery and radiotherapy. It was discussed in detail that a complete removal of the larynx may be necessary. The patient wishes to avoid this as far as possible. There is a history of occlusion of the right carotid artery in 1997 with apoplexy and hemiparesis on the left. This is also shown on CT. Based on the medical history and clinical findings, indication for the above-mentioned procedure. \ No newline at end of file diff --git a/263/icd_codes.txt b/263/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..707954ccd1050ed792a684920cfe8391d3611978 --- /dev/null +++ b/263/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 R] \ No newline at end of file diff --git a/263/ops_codes.txt b/263/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..03a9d208e0a7f84867181d479de5d1105f70b3cc --- /dev/null +++ b/263/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 R] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/263/patient_clinical_data.json b/263/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b7c6af6071a9c8d116a5562b1f8802c666c2e916 --- /dev/null +++ b/263/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 45, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/263/patient_pathological_data.json b/263/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b4fbc29c77b3cfd7002346a520c27df93f82240b --- /dev/null +++ b/263/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "263", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 10, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/263/surgery_description.txt b/263/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..455f56467cae3a482e79a5df0881171afcea47bc --- /dev/null +++ b/263/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection, Visor tracheotomy, Selective neck dissection diff --git a/263/surgery_report.txt b/263/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..de4eb0d05d37e28ec22f30493ff3a2eeb2d804b1 --- /dev/null +++ b/263/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater. Followed by active patient identification. Consultation with anesthesia colleagues. Carrying out the team time-out. Two ECs in the blood bank. Induction of anesthesia and tracheo-bronchoscopy with 0° optics by and . This revealed the previously described finding of an exophytic mass of the entire vocal fold on the right side that extends subglottically and the anterior commissure could not be seen completely. Due to the extension, especially to the subglottic side, a partial laryngectomy, if necessary, was decided in the tumor conference. This is confirmed here. Now intubation by the anesthetist. Head positioning by the surgeon. Discussion of the skin incision with . Skin disinfection and infiltration anesthesia in the area of the planned skin incision and 10 ml Ultracaine. Skin disinfection and sterile draping of the surgical site. Marking of the landmarks of the jugulum, incisura thyroidea, cricoid cartilage and the central chin. Draw the skin incision from the hyoid bone in a zigzag shape running caudally in a skin fold, just below the cricoid cartilage. Now make the skin incision using a scalpel and cut through the subcutaneous and cutaneous tissue. Expose the platysma. Dissection of the platysma and subplatysmal preparation. Exposure of the infrahyoid musculature. Enter the median plane and expose and dissect the thyroid cartilage as well as the ligamentum conicum, cricothyroid muscle and the ring button. Subsequent dissection of the perichondrium. An incision is made in the right paramedian using a scalpel. Then form a posteriorly pedicled periosteal flap to the right and left. Then open the thyroid cartilage paramedian on the left using a wheel. Prior to this, horizontal entry into the conic ligament with the scissors. Ensure that a sufficient piece of ligamentum conicum remains caudal to the thyroid cartilage for subsequent suturing. Now dissect alternately with . Endolaryngeal lumen is exposed. This shows the exophytic tumor, which occupies the entire right vocal fold and extends into the anterior commissure as well as subglottically and into the morgue sinus. First, the tumor is dissected subperiosteally on the left side using a Freer and the tumor is placed at a safe distance in the anterior third of the left vocal fold. Subperichondrial dissection is then performed on the right side using Freer until just before the vocal process of the arytenoid cartilage. Ventrally, there is a questionable erosion of the thyroid cartilage, so saw it out as a triangular wedge on the right side. After further caudal dissection, the tumor can be completely resected down to the cricoid cartilage using a Freer and then using scissors down to the subglottic level. This is then thread-marked (vocal fold on the left, cranial sinus morgagni, caudal subglottic, dorsal posterior arytenoid and wound bed) for frozen section. The frozen section shows that the wound bed is just R0 and just reaches the resection margins in the area of the ary. For this reason, a resection is performed in the area of the wound bed between the cricoid cartilage and thyroid cartilage, which also goes to the frozen section. This is ultimately free. In addition, a resection and then a further marginal sample, dorsal ary, is again sent to the frozen section. This again shows CIS. Therefore, after demonstrating the findings to and as the patient wanted to avoid a laryngectomy if possible and had no previous history of swallowing problems, another resection was performed. The vocal process of the arytenoid is also resected. This is repeated as a resection for the frozen section. Finally, a third marginal sample is taken by skeletonizing the arytenoid up to the interary area. This ultimately reveals an R0 situation in the frozen section. Targeted and intensive hemostasis is then performed. Between the frozen section breaks and due to the tumor extension to the subglottic area, a tracheotomy is performed. This involves exposing the bovine cartilage. Undermining of the isthmus of the thyroid gland. This is narrow and thin. Therefore, successive coagulation of the same and transection of the same and exposure of the anterior surface of the trachea. The skin was mobilized up to the jugulum and the incision widened again. Then, entry and identification between the second and third cricoid cartilage. Creation of tracheostomy sutures in the sense of caudal back-stitch sutures, as there are two in total, and two sutures cranially and reintubation. Now recommends a selective neck dissection level II to IV due to the extent of the tumor in the sense of a transglottic carcinoma from supraglottic to subglottic. This is also performed during the frozen section break. To do this, mark the landmarks of the mastoid and sternocleidomastoid anterior margin on the right side and mark the skin incision. Then cut through the cutaneous and subcutaneous tissue and the platysma using a scalpel. Exposure of the sternocleidomastoid anterior margin. Exposure of the omohyoid muscle, which crosses over the jugular vein. Dissection on the sterno caudally and exposure and sparing of the accissor nerve. The neck is short overall and contains a lot of fatty tissue. Therefore difficult dissection conditions. Exposure of the course of the omohyoid muscle from caudal to cranial. Meticulous care is taken not to make any connection to the other surgical site. Exposure of the caudal belly of the submandibular salivary gland. Exposure of the digaster venter anterior muscle up to the omo. Exposure of the digaster venter posterior muscle up to the jugular vein. This is also visualized from caudal to cranial up to the junction with the digaster venter posterior muscle. Here the medial neck preparation is very voluminous. During careful dissection in this area, between the jugular vein and the digaster venter posterior muscle, i.e. medial/cranial to the internal jugular vein, there is an injury to an arterial vessel despite digital palpation. This was found not to be pulsating on palpation. Further dissection of this vessel revealed that it was a completely sclerosed internal carotid artery. Due to its kinking, in the sense of a vascular anomaly, it lies medially cranial to the internal jugular vein. There is no bleeding here as it is completely sclerosed. The vascular surgeon is called in immediately. The pupils are equal at all times. The colleague confirms on CT that the internal carotid artery is completely occluded just above the bifurcation. She then completely transected the internal carotid artery. This shows that there is no reflux or flow. She ligated the cranial end and made several stitches around the caudal end using a prolene. This concludes the procedure. Now expose the hypoglossal nerve and the vagus nerve. Both are spared. Expose the facial vein and the cervical vein from caudal to cranial. The medial neck preparation is now removed. The superior thyroid artery is also exposed and spared. The vagus nerve and the accessorius nerve are exposed. The lateral neck preparation level V is left in place. Then, after insertion of a Redon and suturing of the same, two-layer wound closure. This was preceded by irrigation with H2O2 and Ringer's. Another meticulous inspection of the surgical site. This is completely dry, after still occasional targeted bipolar coagulation. Then two-layer wound closure using subcutaneous suture and cutaneous suture. Finally, after re-inspection of the laryngeal site and bipolar coagulation, supra-tip swabs are inserted. For closure, the edges of the larynx are very well adapted using 4.0 Vicryl with three sutures. The perichondrium suture is then applied. This is placed completely over the larynx and closes it completely and very well. The coniotomy is also closed. This results in a very good aspect. Insertion of a narrow flap between the thyroid cartilage and the infrahyoid muscles. This is now also sutured successively from cranial to caudal over the thyroid cartilage using single button sutures, so that this is very well covered and there is no indication of a fistula. Subcutaneous suture, including the platysma, and cutaneous suture. Intraoperative administration of clindamycin and reintubation with a seven-gauge Rüsch cannula. Application of a pressure bandage. Intraoperative until the end of the operation, pupils equal and narrow on both sides. Now end of the procedure. The patient goes to the intensive care unit for monitoring. Conclusion: Postoperative administration of Clindamycin 4 x 600 mg over 24 hours. Continue with pressure bandage. A nasogastric tube was placed. Ligation of the ACI on the right in a complete stenosis that had been present for 20 years in post-apoplexy on the right with hemiparesis on the left. Check of the neurological status. Please note the final histology. Presentation at the tumor conference and clarification of the procedure regarding the bronchial carcinoma. \ No newline at end of file diff --git a/264/InvasionFront_CD3_block13_x3_y1_patient264_0.json b/264/InvasionFront_CD3_block13_x3_y1_patient264_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d41c7b22344fb8efbbe3b03bbb15e1abe6444972 --- /dev/null +++ b/264/InvasionFront_CD3_block13_x3_y1_patient264_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 2148.9, + "Num Detections": 15151, + "Num Negative": 15089, + "Num Positive": 62, + "Positive %": 0.4092, + "Num Positive per mm^2": 36.28 + } +} \ No newline at end of file diff --git a/264/InvasionFront_CD3_block13_x4_y1_patient264_1.json b/264/InvasionFront_CD3_block13_x4_y1_patient264_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ecf6683447b9a3725e3afa04fb58f9d61f6c8ab0 --- /dev/null +++ b/264/InvasionFront_CD3_block13_x4_y1_patient264_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 2098.9, + "Num Detections": 15463, + "Num Negative": 15440, + "Num Positive": 23, + "Positive %": 0.1487, + "Num Positive per mm^2": 12.63 + } +} \ No newline at end of file diff --git a/264/InvasionFront_CD8_block13_x3_y1_patient264_0.json b/264/InvasionFront_CD8_block13_x3_y1_patient264_0.json new file mode 100644 index 0000000000000000000000000000000000000000..051def61277755036a75a99e47a29bef8723da43 --- /dev/null +++ b/264/InvasionFront_CD8_block13_x3_y1_patient264_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12768.2, + "Centroid Y µm": 3573.1, + "Num Detections": 16036, + "Num Negative": 15872, + "Num Positive": 164, + "Positive %": 1.023, + "Num Positive per mm^2": 92.34 + } +} \ No newline at end of file diff --git a/264/InvasionFront_CD8_block13_x4_y1_patient264_1.json b/264/InvasionFront_CD8_block13_x4_y1_patient264_1.json new file mode 100644 index 0000000000000000000000000000000000000000..20225298404ffaa6a3bfb49a7c96d08a96170c66 --- /dev/null +++ b/264/InvasionFront_CD8_block13_x4_y1_patient264_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15341.9, + "Centroid Y µm": 3673.1, + "Num Detections": 17715, + "Num Negative": 17380, + "Num Positive": 335, + "Positive %": 1.891, + "Num Positive per mm^2": 173.22 + } +} \ No newline at end of file diff --git a/264/TumorCenter_CD3_block13_x3_y1_patient264_0.json b/264/TumorCenter_CD3_block13_x3_y1_patient264_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b1a0fa8a7bf2d471daaaeda9dd92492f07080be9 --- /dev/null +++ b/264/TumorCenter_CD3_block13_x3_y1_patient264_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12993.1, + "Centroid Y µm": 9120.2, + "Num Detections": 16843, + "Num Negative": 16757, + "Num Positive": 86, + "Positive %": 0.5106, + "Num Positive per mm^2": 43.72 + } +} \ No newline at end of file diff --git a/264/TumorCenter_CD3_block13_x4_y1_patient264_1.json b/264/TumorCenter_CD3_block13_x4_y1_patient264_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e5a0ec8b1a3941cbb041cf452152ebc35ba3c781 --- /dev/null +++ b/264/TumorCenter_CD3_block13_x4_y1_patient264_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15416.8, + "Centroid Y µm": 9270.1, + "Num Detections": 15745, + "Num Negative": 15679, + "Num Positive": 66, + "Positive %": 0.4192, + "Num Positive per mm^2": 35.15 + } +} \ No newline at end of file diff --git a/264/TumorCenter_CD8_block13_x3_y1_patient264_0.json b/264/TumorCenter_CD8_block13_x3_y1_patient264_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4ecbe07922700e534fe6ba89e2ec2cc874e6951b --- /dev/null +++ b/264/TumorCenter_CD8_block13_x3_y1_patient264_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10244.6, + "Centroid Y µm": 3323.2, + "Num Detections": 15978, + "Num Negative": 15785, + "Num Positive": 193, + "Positive %": 1.208, + "Num Positive per mm^2": 101.1 + } +} \ No newline at end of file diff --git a/264/TumorCenter_CD8_block13_x4_y1_patient264_1.json b/264/TumorCenter_CD8_block13_x4_y1_patient264_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b2c01820daf1d3e77ffe928934456f1ee7d2b485 --- /dev/null +++ b/264/TumorCenter_CD8_block13_x4_y1_patient264_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12668.3, + "Centroid Y µm": 3048.4, + "Num Detections": 15948, + "Num Negative": 15856, + "Num Positive": 92, + "Positive %": 0.5769, + "Num Positive per mm^2": 50.05 + } +} \ No newline at end of file diff --git a/264/history_text.txt b/264/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a777bba8350d550168467bf6d6bad9e2a940464b --- /dev/null +++ b/264/history_text.txt @@ -0,0 +1 @@ +A cT4a cN0 hypopharyngeal carcinoma was confirmed in the patient during an emergency panendoscopy with tracheotomy. Emergency intervention already <2012>. <2012> the panendoscopy was performed to plan the surgical procedure and the PEG was placed. CT scan and clinically extensive laryngeal destruction with extensive growth per continuitatem in the soft tissues of the neck on the left. The multimorbid patient has a pronounced peripheral arterial occlusive disease with a history of leg amputation on both sides. \ No newline at end of file diff --git a/264/icd_codes.txt b/264/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8942df050249e3880166bd6eaf35efe4c40f2c9 --- /dev/null +++ b/264/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] \ No newline at end of file diff --git a/264/ops_codes.txt b/264/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e3c63518bf977cc4615104599fb3c72a6ddb2e79 --- /dev/null +++ b/264/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie und Schilddrüsenresektion mit Rekonstruktion mit gestieltem Fernlappen[5-303.25 ] Gestielter regionaler Lappen mit Fernlappen Haut und Unterhaut Brustwand und Rücken[5-906.2a ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/264/patient_clinical_data.json b/264/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f162b46b68aa4d09cc4d4397ad575310f8bd7f32 --- /dev/null +++ b/264/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 76, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/264/patient_pathological_data.json b/264/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..abf2bf2c7f4861584e6a176e434a9b9d86d3d69e --- /dev/null +++ b/264/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "264", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/264/surgery_description.txt b/264/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a02a39088d7ac6d2e902ceb6d44ef7d7321d2ebd --- /dev/null +++ b/264/surgery_description.txt @@ -0,0 +1 @@ +Pharyngolaryngotomy diff --git a/264/surgery_report.txt b/264/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..efc4b6fe33bf94c2c0da87728a3120e6f9061cd1 --- /dev/null +++ b/264/surgery_report.txt @@ -0,0 +1 @@ +After intubation via the supine tracheostoma and preparation by the anesthesia colleagues, a pharyngo/laryngoscopy was first performed. As described above, the tumor was found in the area of the left hypopharynx with extensive laryngeal destruction, extensive postcricoid growth towards the esophageal opening and extending directly in front of it. Growth towards the crania, also into the pre-epiglottic fatty tissue. Fixation of the hyoid on the right side, free conditions, with the tumor clearly reaching the midline, especially in the caudal transition. Inspection of the tracheostoma: the tracheostoma is reddened peristomally. Close inspection reveals a suspicious lesion in the area of the mucocutaneous anastomosis on the left side. This is a growth in the area of the tracheostoma. Therefore, skin incision to the apron flap with complete circumcision of the tracheostoma. Elevation of the apron flap with elevation of the platysma. Elevation of the platysma. First expose the sternocleidomastoid muscle on the right side, expose the omohyoid muscle of the submandibular gland and the digastric muscle. Dissection of the omohyoid muscle and initial attempt to visualize the laryngeal skeleton. This shows that the laryngeal skeleton on the right side has also been penetrated by tumor. Therefore, a muscular cuff was then left in place. Exposure and release of the hyoid on the right side. Ligation of the upper laryngeal bundle. Exposure and separation of the entire cervical vascular sheath. Dissection down to the prevertebral fascia. Mobilization of the larynx from the prevertebral fascia. This shows no infiltration by the tumor. Then, after complete loosening of the soft tissue on the right side, entry on the left side. This reveals infiltration of the sternocleidomastoid muscle and tumor infiltration of the right-sided cervical vascular sheath. Exposure of the submandibular gland and the digastric muscle. Exposure and later ligation of the facial vein. Release of the sternocleidomastoid muscle cranially and caudally in the area of origin. Exposure and later removal of the accessorius nerve. Removal of the neck preparation. Here complete. First expose the internal jugular vein cranially and caudally. Release of the cervical part of the tumor, including level V and partial revision of the cervical plexus. Despite the previous mobilization of the surrounding tissue, there is now evidence of widespread infiltration of the cervical vascular sheath. Therefore now careful opening. Exposure of the common carotid artery and cranial dissection. Exposure of the vagus nerve. Tumor growth is now clearly visible in the internal jugular vein. This is therefore removed cranially and caudally. In addition, there is a small growth on the vagus nerve and a circumscribed macroscopic change in the nerve. In addition, direct infiltration of the perivascular tissue of the common carotid artery with detachment of the perivascular tissue. The tumor can now be separated by initially bluntly detaching the vagus nerve. A marginal sample was taken in the area of the common carotid artery on the detached perivascular tissue, also in the marginal area of the vagus nerve. Clear cranial infiltration of the superior thyroid artery, which is separated. The further course of the external carotid artery is now free, so that after visualization and preservation of the hypoglossal nerve, no extension of the radicality is required here. In the frozen section diagnostics, the marginal samples in the area of the vagus nerve as well as in the area of the common carotid artery are now tumor positive. Therefore, after discussing the case and demonstrating the findings to , long-distance resection of the vagus nerve and resection of the remaining perivascular connective tissue, but with preservation of the actual vessel wall. The vagus nerve is resected in an elongated fashion and sent for definitive histology. The post-resectate in the area of the common carotid artery is assessed as tumor-free. Exposure of the prevertebral fascia and complete detachment of the pharyngeal tube. Left-sided partial thyroidectomy also on the right side with adherence to the tumor DD scarred by the tracheotomy. Complete incision of the tracheostoma. Exposure of the trachea caudally, which is macroscopically and palpatorily free. Now turn to definitive tumor resection. To do this, enter above the hyoid on the right side, enter the right-sided vallecula, snare the epiglottis, widen the pharyngotomy. Resection along the right aryepiglottic fold. Due to the extensive laryngeal infiltration, the right-sided piriform sinus can only be partially released. Significant extensive postcricoid growth, here growing submucosally. Therefore, the entire postcricoid region must also be resected. As described above, the tumor can be seen in the area of the left piriform sinus as well as the left pharyngeal wall, in some cases extending to the midline. Excision of the tumor with a safety margin of approx. 1 cm, macroscopically in sano, macroscopically altered parts of the pharynx were removed. After removal, a caudal complete pharyngotomy with circular pharyngeal resection is performed; cranially, an approx. 2-5 cm wide pharyngeal strip can be preserved. Completely imaged marginal samples are now taken from the entire area of the detached mucosa as well as in the area of the base of the tongue and towards the esophagus. A marginal sample is also taken in the area of the separated trachea and in the area of the peristomally separated skin. These are diagnosed as completely tumor-free in the frozen section diagnostics, so that a local R0 situation can be assumed overall. Now complete the neck dissection of the right side. Due to the tumor resection, an extended radical neck dissection of the left side was performed en bloc on the specimen. Complete exposure of the digastric muscle on the right side. Exposure of the accessory nerve, exposure of the internal jugular vein, exposure and preservation of the facial vein, exposure and preservation of the hypoglossal nerve. Dissection of the internal jugular vein. Dissection of the accessorius triangle with careful protection of the nerve. Dissection of level V with careful protection of the cervical plexus branches. Finally, the defect is measured when the wound is dry. Due to the highly critical vascular supply and the radical resection, microvascular reconstruction is not performed. Elevation of a pedicled pectoralis major graft measuring up to 14 x 9 cm in total from the left. For this purpose, marking of the flap for complete pharyngeal reconstruction and marking of a temporary deltopectoral flap. This is lifted up to the 2nd angiosome, strictly subfascial preparation. Incision of the pectoralis major flap. Broad-based caudal dissection up to the rectus aponeurosis. Release of the pectoralis major muscle. Suture fixation of the muscle to the skin island. Cranial dissection strictly subfascial including the pectoralis major muscle. Exposure of the pectoralis minor muscle and the pedicle vessels. Subsequent resection of the muscle, leaving a cuff around the vascular pedicle. Cranial complete release of the pedicle vessel to allow maximum rotation and maximum freedom from tension. Creation of a wide cervical skin tunnel. Complete tension-free placement and insertion into the pharyngeal defect. A nasogastric tube was previously inserted into the separated esophagus. The surrounding skin is then carefully and extensively mobilized pectorally. Careful hemostasis. Subsequent strong and multi-layered wound closure after insertion of two 10-gauge Redon drains. Resection of protruding skin and subsequent repositioning of the temporarily elevated deltopectoral flap. Cervically, the graft is successively sutured to the separated esophagus under visualization. Strictly inverting suture at the mucosal level. Reanastomosis of the caudal part of the pharynx into the esophageal reconstruction to avoid subsequent stenosis, successive incorporation of the graft. Final good fit. Creation of a wide pharyngeal tube as well as intact and tight conditions on all sides with the flap in proper vitality. After final wound inspection, the tracheostoma is sutured and a 10-gauge Redon drainage tube is inserted and the wound is carefully closed in two layers. Re-intubation onto a 12 Rüsch cannula, which is suture-fixed, and completion of the procedure at this point. The patient received intraoperative intravenous antibiotics with Unacid 3 g, which should be continued for 24 hours postoperatively. Careful postoperative wound control in case of high risk of fistula due to complete pharyngectomy. Overall intraoperatively, a narrow R0 situation can be assumed in the area of the left common carotid artery, with overall extensive findings of a cT4a cN0 hypopharyngeal carcinoma on the left. In the case of regular wound conditions, an X-ray pre-swallow was performed on the 10th postoperative day. \ No newline at end of file diff --git a/265/InvasionFront_CD3_block22_x1_y10_patient265_0.json b/265/InvasionFront_CD3_block22_x1_y10_patient265_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a261f08d1b9140de18f504e2e7294fa27139fe91 --- /dev/null +++ b/265/InvasionFront_CD3_block22_x1_y10_patient265_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4122.8, + "Centroid Y µm": 36230.8, + "Num Detections": 14704, + "Num Negative": 13944, + "Num Positive": 760, + "Positive %": 5.169, + "Num Positive per mm^2": 465.51 + } +} \ No newline at end of file diff --git a/265/InvasionFront_CD3_block22_x2_y10_patient265_1.json b/265/InvasionFront_CD3_block22_x2_y10_patient265_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a1bd57805b1b1b63edeb63d15d31bc568991af26 --- /dev/null +++ b/265/InvasionFront_CD3_block22_x2_y10_patient265_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 36755.5, + "Num Detections": 18381, + "Num Negative": 16879, + "Num Positive": 1502, + "Positive %": 8.171, + "Num Positive per mm^2": 700.65 + } +} \ No newline at end of file diff --git a/265/InvasionFront_CD8_block22_x1_y10_patient265_0.json b/265/InvasionFront_CD8_block22_x1_y10_patient265_0.json new file mode 100644 index 0000000000000000000000000000000000000000..299658ce4df69423b1edd6a57eeb35734333f7ae --- /dev/null +++ b/265/InvasionFront_CD8_block22_x1_y10_patient265_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7087.8, + "Centroid Y µm": 24895.1, + "Num Detections": 13896, + "Num Negative": 13718, + "Num Positive": 178, + "Positive %": 1.281, + "Num Positive per mm^2": 114.28 + } +} \ No newline at end of file diff --git a/265/InvasionFront_CD8_block22_x2_y10_patient265_1.json b/265/InvasionFront_CD8_block22_x2_y10_patient265_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e5d75d9d8e4116c8e59d52a052551aac2ec5250 --- /dev/null +++ b/265/InvasionFront_CD8_block22_x2_y10_patient265_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9274.0, + "Centroid Y µm": 25068.0, + "Num Detections": 18520, + "Num Negative": 17769, + "Num Positive": 751, + "Positive %": 4.055, + "Num Positive per mm^2": 362.62 + } +} \ No newline at end of file diff --git a/265/TumorCenter_CD3_block22_x1_y10_patient265_0.json b/265/TumorCenter_CD3_block22_x1_y10_patient265_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d5567eaddcbfb395d56ba71b748aca97ef59702d --- /dev/null +++ b/265/TumorCenter_CD3_block22_x1_y10_patient265_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3596.4, + "Centroid Y µm": 24880.2, + "Num Detections": 13978, + "Num Negative": 13862, + "Num Positive": 116, + "Positive %": 0.8299, + "Num Positive per mm^2": 59.81 + } +} \ No newline at end of file diff --git a/265/TumorCenter_CD3_block22_x2_y10_patient265_1.json b/265/TumorCenter_CD3_block22_x2_y10_patient265_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dfcda72fb8c783a97ca04f7acf1e7faded763edf --- /dev/null +++ b/265/TumorCenter_CD3_block22_x2_y10_patient265_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5792.0, + "Centroid Y µm": 25203.4, + "Num Detections": 11144, + "Num Negative": 10856, + "Num Positive": 288, + "Positive %": 2.584, + "Num Positive per mm^2": 148.15 + } +} \ No newline at end of file diff --git a/265/TumorCenter_CD8_block22_x1_y10_patient265_0.json b/265/TumorCenter_CD8_block22_x1_y10_patient265_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a1be51e3639fbba3248790d1f4d604595243731f --- /dev/null +++ b/265/TumorCenter_CD8_block22_x1_y10_patient265_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5645.2, + "Centroid Y µm": 34502.6, + "Num Detections": 19600, + "Num Negative": 19573, + "Num Positive": 27, + "Positive %": 0.1378, + "Num Positive per mm^2": 12.64 + } +} \ No newline at end of file diff --git a/265/TumorCenter_CD8_block22_x2_y10_patient265_1.json b/265/TumorCenter_CD8_block22_x2_y10_patient265_1.json new file mode 100644 index 0000000000000000000000000000000000000000..701149ce3e5c67470f294e496ad64d50866ee536 --- /dev/null +++ b/265/TumorCenter_CD8_block22_x2_y10_patient265_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7853.6, + "Centroid Y µm": 34856.7, + "Num Detections": 18968, + "Num Negative": 18743, + "Num Positive": 225, + "Positive %": 1.186, + "Num Positive per mm^2": 102.58 + } +} \ No newline at end of file diff --git a/265/history_text.txt b/265/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c97648d1521117988364b847d9485c9dab5deba9 --- /dev/null +++ b/265/history_text.txt @@ -0,0 +1 @@ +A cT4a cN0 G3 glottic carcinoma was confirmed in the patient in conjunction with panendoscopy and CT diagnostics. Right-sided process with clear laryngeal penetration on CT and subglottic extension on panendoscopy. \ No newline at end of file diff --git a/265/icd_codes.txt b/265/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/265/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/265/ops_codes.txt b/265/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b3ad7ca11cf846d4eb7de6dccb2f3f869164ad1e --- /dev/null +++ b/265/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 B] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/265/patient_clinical_data.json b/265/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..378e14b277a2335e02260abf90e8dd4be8700bec --- /dev/null +++ b/265/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/265/patient_pathological_data.json b/265/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cde3bc4c53ec284063890463cccf0480dd36966b --- /dev/null +++ b/265/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "265", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 32, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 14.0 +} \ No newline at end of file diff --git a/265/surgery_description.txt b/265/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f1b3646d8f9e116a66e0ae42fe9ea76ca8bc8fe --- /dev/null +++ b/265/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy diff --git a/265/surgery_report.txt b/265/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..84334769c49c0c31be960ffc4d2e2ded68ca6234 --- /dev/null +++ b/265/surgery_report.txt @@ -0,0 +1 @@ +After bronchoscopic intubation and preparation by the anesthesia colleagues, the patient is positioned. Initially, the Kleinsasser tube is inserted under dental protection. The oral cavity and oropharynx are unremarkable, and the hypopharynx up to the tips of the piriform sinus and the entrance to the oesophagus is also unremarkable and clear. Subsequent endoscopically controlled insertion of a nasogastric feeding tube. Adjustment of the endolarynx. The exophytic tumor process can be seen on the right side, but in the area of the anterior commissure there is also a transition to the opposite side and palpation reveals a clear fixation on the laryngeal skeleton. Posteriorly, the mass extends to the arytenoid, so that a laryngectomy is indicated for oncological and functional reasons. The patient was then repositioned. Injection of xylocaine with added adrenaline. Skin incision and lifting of an apron flap. Palpation of the laryngeal skeleton reveals the tumor section that has broken through, but this does not go into the skin. To ensure that a soft tissue mantle is preserved, the platysma is left on the specimen in the relevant area, otherwise the platysma is dissected cranially. High suture of the apron flap on both sides Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digastric muscle. Carry out the neck dissection starting with the left side. First dissect the anterior part of the neck, preserving the cervical anterior aspect of the facial vein, the superior thyroid artery and the hypoglossal nerve. Expose the accessory nerve and complete level V while carefully preserving the cervical plexus roots. Macroscopically no suspicious nodes on the left side. Careful hemostasis and turning to the opposite side. Same procedure in principle here, also not resected separately. Left-sided release of the thyroid cartilage horn, release of the piriform sinus. Subsequent right-sided release of the piriform sinus. Caudal free dissection of the trachea and the cricoid cartilage. Dissection of the thyroid isthmus and exposure of the anterior surface of the trachea. Release of the hyoid and preservation of the surrounding musculature. Entering the vallecula. Extension of the pharyngotomy. Resection of the specimen along the aryepiglottic folds. Now a good overview of the tumor, which adheres to the right or anteriorly to the thyroid cartilage and infiltrates it. The laryngeal musculature on the right side is not perforated, but all soft tissue is left on the specimen as described above, so that a safe in sano resection is achieved in the anterior region. Postcricoid resection sparing the mucosa. Release of the piriform sinus. In the case of inital subglottic expansion, resection of the first tracheal clasp and removal of the preparation. As suspected, this shows a clear subglottic expansion with growth approx. 1.5 cm below the glottic level, but here too a safe in sano resection. Also on the specimen in sano resection with here also supraglottic expansion in the area of the petiolus and the beginning laryngeal epiglottis area. To confirm the R0 situation in the area of the mucosa covering the margins as well as in the area of the tracheal margin. No higher-grade dysplasia or tumor is found here, meaning that a safe R0 resection has been achieved. The anterior wall of the trachea is then resected. A Provox prosthesis of size 8 mm is placed at the cranial tracheal margin. The two-layer inverted closure of the pharyngeal defect is then performed under wide and strong mucosal conditions. Overall intact conditions. This is followed by transection of the sternocleidomastoid muscle insertions close to the stone on both sides. Subsequent wound inspection and wound irrigation and, if the wound was completely dry, insertion of two size 10 Redon drains and subsequent insertion of the tracheostoma as well as careful two-layer wound closure and finally reintubation with a size 10 low cuff cannula and completion of the procedure without any indication of complications. Note: The patient received 3 g Unacid intraoperatively; please continue this for 24 hours postoperatively. Conclusion: Intraoperative R0 resected cT4a cN0 G3 glottic laryngeal carcinoma with thyroid cartilage perforation and both supra- and subglottic extension. In the absence of clinical signs of a pharyngeal fistula, please perform a postoperative X-ray pre-swallow on the 8th to 9th postoperative day. \ No newline at end of file diff --git a/266/InvasionFront_CD3_block20_x3_y5_patient266_0.json b/266/InvasionFront_CD3_block20_x3_y5_patient266_0.json new file mode 100644 index 0000000000000000000000000000000000000000..261656184740297ac342a2e0ea4f5a27923556f4 --- /dev/null +++ b/266/InvasionFront_CD3_block20_x3_y5_patient266_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12418.4, + "Centroid Y µm": 12418.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/266/InvasionFront_CD3_block20_x4_y5_patient266_1.json b/266/InvasionFront_CD3_block20_x4_y5_patient266_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b7811d2b399a1f2456bee1cb4d400b13bb2ea174 --- /dev/null +++ b/266/InvasionFront_CD3_block20_x4_y5_patient266_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15117.0, + "Centroid Y µm": 12643.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/266/InvasionFront_CD8_block20_x3_y5_patient266_0.json b/266/InvasionFront_CD8_block20_x3_y5_patient266_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d620d9aff4460f74c60992c48fbcb70a61071e68 --- /dev/null +++ b/266/InvasionFront_CD8_block20_x3_y5_patient266_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11743.8, + "Centroid Y µm": 12893.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/266/InvasionFront_CD8_block20_x4_y5_patient266_1.json b/266/InvasionFront_CD8_block20_x4_y5_patient266_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b7581d188da1344afe008e23521acc76fdb29f9e --- /dev/null +++ b/266/InvasionFront_CD8_block20_x4_y5_patient266_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 12818.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/266/TumorCenter_CD3_block20_x3_y5_patient266_0.json b/266/TumorCenter_CD3_block20_x3_y5_patient266_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7fac4049d093664cecda3c4d668fca8eb4414c88 --- /dev/null +++ b/266/TumorCenter_CD3_block20_x3_y5_patient266_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11152.5, + "Centroid Y µm": 11770.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/266/TumorCenter_CD3_block20_x4_y5_patient266_1.json b/266/TumorCenter_CD3_block20_x4_y5_patient266_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9713a5767184889eca77ca83579d5c66218414f6 --- /dev/null +++ b/266/TumorCenter_CD3_block20_x4_y5_patient266_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13779.6, + "Centroid Y µm": 11737.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/266/TumorCenter_CD8_block20_x3_y5_patient266_0.json b/266/TumorCenter_CD8_block20_x3_y5_patient266_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9abdccdf786ddd82e786b47220eaa0e5bc1f2725 --- /dev/null +++ b/266/TumorCenter_CD8_block20_x3_y5_patient266_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 12518.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/266/TumorCenter_CD8_block20_x4_y5_patient266_1.json b/266/TumorCenter_CD8_block20_x4_y5_patient266_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f3e48077c74694767303cabfa3fd2bef5e4fcfe7 --- /dev/null +++ b/266/TumorCenter_CD8_block20_x4_y5_patient266_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13293.0, + "Centroid Y µm": 12418.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/266/history_text.txt b/266/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/266/icd_codes.txt b/266/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ab9abdd5d2316936b8a63a0a5cb34a33143abb6 --- /dev/null +++ b/266/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 L] Zervikale Lymphknotenmetastase[C77.0 L] \ No newline at end of file diff --git a/266/ops_codes.txt b/266/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dc613f74c3628ee256d8f86854e7c9f04224f6d9 --- /dev/null +++ b/266/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie ohne Rekonstruktion[5-303.00 ] Radikale Neck dissection in 4 Regionen[5-403.10 L] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 R] Diagnostische Ösophagogastroskopie[1-631 ] PEG-Sonde Anlage[5-431.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/266/patient_clinical_data.json b/266/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dc7d65ae0f0e97c5b3e9ccb7c2956acd9d26ddbb --- /dev/null +++ b/266/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 55, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/266/patient_pathological_data.json b/266/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6db9db00eac6db301e751769b5f34a6616209aad --- /dev/null +++ b/266/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "266", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN3", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 21.0 +} \ No newline at end of file diff --git a/266/surgery_description.txt b/266/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d172e06bea884778383a4bd04efd65d3e5acfbe7 --- /dev/null +++ b/266/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, PEG placement diff --git a/266/surgery_report.txt b/266/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fcaf6062c04871177f06c0ca780267eae779559d --- /dev/null +++ b/266/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by anesthesia colleagues. Intubation transnasally by the anesthesia colleagues. Entry with the Kleinsasser tube and inspection of the hypopharynx, piriform sinus and postcricoid region. No abnormalities here. Attempt to adjust the tumor, which can be seen on the left side in the area of the glottis and supraglottis. Adjustment of the tumor is extremely difficult as the adjustability is very low. CT morphologically, the tumor breaks through the thyroid cartilage. Placement of a nasogastric tube. Repositioning for PEG insertion. Entering with the flexible esophagoscope and advancing into the stomach. Insertion of a PEG using the thread pull-through method. With good diaphanoscopy, this can be done without any problems. Sterile washing and draping. Creation of an apron flap. Preparation of the platysma. Raising and fixation of the apron flap. Start with the neck dissection on the left side. Here you can see a large rough metastasis which macroscopically infiltrates far into the sternocleidomastoid. Therefore, expose the sternocleidomastoid and the submandibular gland, the omohyoid muscle and remove the sternocleidomastoid muscle in the caudal region. Raise the muscle and dissect along the cervical vascular sheath in a cranial direction. It can be clearly seen that the internal jugular vein has a very small caliber, so that it can be assumed that the tumor has also penetrated the vein. This also becomes clear on further dissection. The vein is therefore clamped and cut in the caudal area and the ends are ligated. Further dissection cranially along the external and internal carotid artery. The metastasis can be easily pushed away from these vessels. The metastasis also infiltrates the posterior digastric venter muscle. This is also partially removed. The hypoglossal nerve can be spared and the facial vein must unfortunately also be removed. Removal of the metastasis and removal of the legal neck block II a to V a, sparing the plexus branches, whereby it must be said that the accessorius nerve and the cranial plexus branches were also partially resected, as these have penetrated directly into the metastasis. Turning to the opposite side. Exposure of the sternocleidomastoid, omohyoid, digastric and submandibular gland and exposure of the cervical vascular sheath. Free preparation of the internal jugular vein, the facial vein and removal of the neck levels II a to V a, while sparing the plexus branches. Detachment of the neck vessels from the pharynx and larynx area. Exposure of the hyoid bone. Detachment of the base of the tongue from the hyoid bone. Skeletonization of the larynx with detachment of the oblique laryngeal musculature. Entering the pharynx, just above the hyoid bone. Pulling out the epiglottis and cutting along the epiglottis to the postcricoid region, initially on the right side. Inspection of the tumor region. This breaks through the thyroid cartilage ventrally and also laterally on the left. A great deal of tissue is left in the ventral and lateral region of the laryngeal preparation. The thyroid gland is difficult to dissect and is therefore sharply dissected to avoid getting into the tumor. Further dissection of the laryngeal preparation and removal of the larynx below the cricoid cartilage. Before this, a tracheostoma was created and the ventilation tube was intubated. Removal of a resected specimen with a marginal sample from the thyroid gland area, as the tumor is at least very close here macroscopically. The marginal sample from the thyroid gland is tumor-free. The laryngeal specimen is sent for final histology. Insertion of a Provox prosthesis in the usual manner with the auxiliary trocar, approx. 1 cm below the upper edge of the tracheostoma. A myotomy of the esophageal sphincter is omitted, as this could be passed loosely with a transverse finger. Perform a myotomy in the sternocleidomastoid muscle to achieve a flat stoma. Performing the pharyngeal suture in a three-layered manner with single button sutures, without creating a T. Placement of two Redon drains and two-layer wound closure with epithelialization of the tracheostoma. \ No newline at end of file diff --git a/267/InvasionFront_CD3_block20_x5_y6_patient267_0.json b/267/InvasionFront_CD3_block20_x5_y6_patient267_0.json new file mode 100644 index 0000000000000000000000000000000000000000..33b6853afe9af7abeb682b7c42e5eb8245994311 --- /dev/null +++ b/267/InvasionFront_CD3_block20_x5_y6_patient267_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17315.8, + "Centroid Y µm": 15366.9, + "Num Detections": 21029, + "Num Negative": 20331, + "Num Positive": 698, + "Positive %": 3.319, + "Num Positive per mm^2": 301.29 + } +} \ No newline at end of file diff --git a/267/InvasionFront_CD3_block20_x6_y6_patient267_1.json b/267/InvasionFront_CD3_block20_x6_y6_patient267_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7a2a6e028b14e576f6f62e22fef11de47d68bb7d --- /dev/null +++ b/267/InvasionFront_CD3_block20_x6_y6_patient267_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19964.4, + "Centroid Y µm": 15616.7, + "Num Detections": 23840, + "Num Negative": 23472, + "Num Positive": 368, + "Positive %": 1.544, + "Num Positive per mm^2": 146.68 + } +} \ No newline at end of file diff --git a/267/InvasionFront_CD8_block20_x5_y6_patient267_0.json b/267/InvasionFront_CD8_block20_x5_y6_patient267_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c7310d461f717a4584762d96237ac86e4c439660 --- /dev/null +++ b/267/InvasionFront_CD8_block20_x5_y6_patient267_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16866.1, + "Centroid Y µm": 15017.0, + "Num Detections": 19654, + "Num Negative": 19022, + "Num Positive": 632, + "Positive %": 3.216, + "Num Positive per mm^2": 293.04 + } +} \ No newline at end of file diff --git a/267/InvasionFront_CD8_block20_x6_y6_patient267_1.json b/267/InvasionFront_CD8_block20_x6_y6_patient267_1.json new file mode 100644 index 0000000000000000000000000000000000000000..74c2292e42297d99fc1aa1eec8b832031eb2df14 --- /dev/null +++ b/267/InvasionFront_CD8_block20_x6_y6_patient267_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19539.7, + "Centroid Y µm": 14942.1, + "Num Detections": 20177, + "Num Negative": 19869, + "Num Positive": 308, + "Positive %": 1.526, + "Num Positive per mm^2": 144.72 + } +} \ No newline at end of file diff --git a/267/TumorCenter_CD3_block20_x5_y6_patient267_0.json b/267/TumorCenter_CD3_block20_x5_y6_patient267_0.json new file mode 100644 index 0000000000000000000000000000000000000000..211f3af1ae397acc74d8f191838218bdafc6ffa2 --- /dev/null +++ b/267/TumorCenter_CD3_block20_x5_y6_patient267_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16226.2, + "Centroid Y µm": 14231.1, + "Num Detections": 14410, + "Num Negative": 14336, + "Num Positive": 74, + "Positive %": 0.5135, + "Num Positive per mm^2": 35.84 + } +} \ No newline at end of file diff --git a/267/TumorCenter_CD3_block20_x6_y6_patient267_1.json b/267/TumorCenter_CD3_block20_x6_y6_patient267_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e748c05492f122ab62d90c27bf05a18169f16766 --- /dev/null +++ b/267/TumorCenter_CD3_block20_x6_y6_patient267_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18838.3, + "Centroid Y µm": 14351.4, + "Num Detections": 20650, + "Num Negative": 20133, + "Num Positive": 517, + "Positive %": 2.504, + "Num Positive per mm^2": 226.91 + } +} \ No newline at end of file diff --git a/267/TumorCenter_CD8_block20_x5_y6_patient267_0.json b/267/TumorCenter_CD8_block20_x5_y6_patient267_0.json new file mode 100644 index 0000000000000000000000000000000000000000..70f0f84f94eb9aac847cda1e7a0362ae66529a60 --- /dev/null +++ b/267/TumorCenter_CD8_block20_x5_y6_patient267_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15866.6, + "Centroid Y µm": 14667.2, + "Num Detections": 12868, + "Num Negative": 12656, + "Num Positive": 212, + "Positive %": 1.647, + "Num Positive per mm^2": 146.01 + } +} \ No newline at end of file diff --git a/267/TumorCenter_CD8_block20_x6_y6_patient267_1.json b/267/TumorCenter_CD8_block20_x6_y6_patient267_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a8659a1b0fed2f3f66276c828c726adf713ed4e1 --- /dev/null +++ b/267/TumorCenter_CD8_block20_x6_y6_patient267_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18515.2, + "Centroid Y µm": 14542.3, + "Num Detections": 23830, + "Num Negative": 23003, + "Num Positive": 827, + "Positive %": 3.47, + "Num Positive per mm^2": 329.6 + } +} \ No newline at end of file diff --git a/267/history_text.txt b/267/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/267/icd_codes.txt b/267/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce1602050d47d2df39c878f258f13fc1bb6f114c --- /dev/null +++ b/267/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 B] \ No newline at end of file diff --git a/267/ops_codes.txt b/267/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1c13552fc1f9b4cce04bd1adf98c3b07aa222441 --- /dev/null +++ b/267/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] Sonstige Laryngektomie[5-303.xx ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 4 Regionen[5-403.10 B] Permanente Tracheotomie[5-312.0 ] Ösophagomyotomie pharyngozervikal sonstige[5-420.1x ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/267/patient_clinical_data.json b/267/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1aad502eb1e0519056538ff4695eb4982d4e563a --- /dev/null +++ b/267/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 47, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/267/patient_pathological_data.json b/267/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9495db61d191866252247efbadc992554cdce5ee --- /dev/null +++ b/267/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "267", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 38, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/267/surgery_description.txt b/267/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ee7628f73234e99cfee1c28da02b1bbfe0addb30 --- /dev/null +++ b/267/surgery_description.txt @@ -0,0 +1 @@ +Frontolateral laryngeal partial resection, Neck dissection, Plastic tracheotomy diff --git a/267/surgery_report.txt b/267/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..49edc867da7fb26524aecb94c2a017583c29e137 --- /dev/null +++ b/267/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and bronchoscopic intubation by the anesthesia colleagues. Positioning of the patient by the surgeon. Entry with the Kleinsasser tube and inspection of the hypopharynx. No abnormalities here. Adjustment of the larynx. The previously described mass is visible on the left side. The pocket fold is coarsely thickened with transition of the thickening to the vocal fold. This mass extends into the anterior commissure and endoscopically only extends to the anterior third on the right side. No further tumor infiltration can be seen endoscopically, everything is also clear subglottically. Then sterile washing and draping. Repositioning for plastic tracheostomy. Curved skin incision. Dissection down to the infrahyal musculature. Separate the infrahyal musculature at the midline and push aside. Then cut through the thyroid isthmus and expose the trachea. Enter the trachea between the 2nd and 3rd tracheal cartilage. Creation of a Björk flap and reintubation. Zigzag incision in connection with the tracheostoma in the midline of the neck. Dissection down to the prelaryngeal musculature. Splitting of the fascia of the prelaryngeal musculature. Exposure of the larynx. Incision of the perichondrium on the right side. Formation of a perichondrium flap that extends over to the left side. Cutting through the thyroid cartilage with the oscillating saw, initially in the midline in the upper part of the thyroid cartilage below the incisura. Form a triangle with displacement to the left side. Then incise the supraglottic tissue with the scissors through the sawed incision. Open up the thyroid cartilage and insert a small retractor. Inspection of the situs. Call in , who notes that the tumor is very unclear and begins with the tumor resection. Start on the right side, then move to the left side. The incision is made in such a way that the posterior third of the vocal fold, including the arytenoid cartilage, remains on the right side. On the left side, the ary must be divided and the entire vocal cord and pocket fold removed. Part of the pharyngoepiglottic fold and the lower part of the base of the epiglottis are also removed. A marginal sample is then taken from the pharyngoepiglottic fold up to the arytenoid. The main specimen was removed from the inside of the larynx so that the inner perichondrium remained on the tumor specimen. The specimen is thread-marked for histology. The margin specimen is also sent to histology with a thread marker. The pathologist finds invasive squamous cell carcinoma in the specimen, which is border-forming towards the thyroid cartilage on the left and on the anterior commissure on the right. The patient is referred for resection. A better overview reveals that there is also tumorous tissue subraglottically on the right side. A sample is taken and sent for frozen section and invasive carcinoma with perineural sheath carcinomatosis can be detected in this sample. The findings are therefore discussed with , who also advises a laryngectomy. To do this, widen the incision in the sense of an apron flap. Complete release of the larynx laterally from the thyroid gland on both sides as well as in the area of the cricoid cartilage. Then release the hyoid bone and perform a pharyngotomy, pull out the epiglottis and detach the laryngeal mucosa of the epiglottis and separate the larynx from the pharyngeal mucosa along the epiglottis, then posteriorly below the arytenoid cartilage and behind the postcricoid region, then place the larynx below the cricoid cartilage. The entire laryngeal preparation is thread-marked for final histology. Neck dissection on both sides. On the right, the entire neck is heavily scarred due to previous parotid surgery. The sternocleidomastoid muscle, the submandibular gland and the digastric muscle are visualized. Exposure of the nervus accessorius, the cervical vascular sheath and free preparation of the internal jugular vein and the facial vein. This is relatively difficult due to a strong scar block. On the right side, the thyroid lobe is massively enlarged and a very hard, irregularly shaped but encapsulated mass can be found at the upper pole. This is carefully incised and sent separately for histological examination. Release of the neck preparation level II a to IV, sparing the plexus branches. Identical procedure on the left side. Exposure of the sternocleidomastoid muscle, the submandibular gland and the digastric muscle. Exposure of the cervical vascular sheath. Dissection of the internal jugular vein. Locating and exposing the accessorius nerve. Release of the neck preparation II a to IV, sparing the plexus branches. Then placement of a Provox prosthesis. To do this, enter the esophagus with the protective tube and create a tracheoesophageal fistula. Then, with the help of the trocar, the Provox prosthesis is pulled through using the thread pull-through method. This is successful without any problems. The edges of the Provox prosthesis are rolled out and the Provox is positioned. It is positioned well, very high up and centered on the posterior wall. A subtle myotomy of the esophagus was performed beforehand so that the esophagus is easily passable. A myotomy was then performed at the base of the sternocleidomastoid muscle on both sides to create a flat stoma. Perform the pharyngeal suture. Initially single button sutures with two layers, then careful adaptation of the constrictor pharyngis muscle in this area where it is still completely intact. Care is taken to ensure that the pharynx is not constricted. Now turn to the tachea. The Björk flap is resected and the trachea is pulled upwards. Form a mucocutaneous anastomosis, initially in the lower area. Then suture the zigzag-shaped median skin incision and insert two 10-gauge Redon drainage tubes on both sides and suture the apron flap into the tracheostoma. Two-layer wound closure and reintubation to a 10-gauge tracheostomy tube. The patient is ventilated due to a cardiac problem and can wake up the same evening. Please present the patient to the tumor conference to plan adjuvant radiochemotherapy. PEG placement was initially dispensed with as the tumor was not as extensive at the start of the operation. The PEG must be inserted secondarily after the pharyngeal suture has healed. Until then, nutrition via the inserted nasogastric tube. As usual, on the 10th postoperative day, please carry out a Rötgen pap smear and build up the diet if there is no fistula. Antibiotics can be discontinued after 24 hours. \ No newline at end of file diff --git a/268/InvasionFront_CD3_block13_x1_y4_patient268_0.json b/268/InvasionFront_CD3_block13_x1_y4_patient268_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad285910e704c7261b1e6431065d787dd8257adb --- /dev/null +++ b/268/InvasionFront_CD3_block13_x1_y4_patient268_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3735.5, + "Centroid Y µm": 9407.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/268/InvasionFront_CD3_block13_x2_y4_patient268_1.json b/268/InvasionFront_CD3_block13_x2_y4_patient268_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9c1a6239f3f6a2c87e1510bad77b277f8d4443c --- /dev/null +++ b/268/InvasionFront_CD3_block13_x2_y4_patient268_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6134.3, + "Centroid Y µm": 9382.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/268/InvasionFront_CD8_block13_x1_y4_patient268_0.json b/268/InvasionFront_CD8_block13_x1_y4_patient268_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cca05fae7e8ef918fe40669d358ed7f7120e30e5 --- /dev/null +++ b/268/InvasionFront_CD8_block13_x1_y4_patient268_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4897.4, + "Centroid Y µm": 10619.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/268/InvasionFront_CD8_block13_x2_y4_patient268_1.json b/268/InvasionFront_CD8_block13_x2_y4_patient268_1.json new file mode 100644 index 0000000000000000000000000000000000000000..93703cd05e8bca769a488589f05280261bca486a --- /dev/null +++ b/268/InvasionFront_CD8_block13_x2_y4_patient268_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7371.1, + "Centroid Y µm": 10719.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/268/TumorCenter_CD3_block13_x1_y4_patient268_0.json b/268/TumorCenter_CD3_block13_x1_y4_patient268_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9fd4ad8ea0960b8ce13cf486ed2992b0a64d501f --- /dev/null +++ b/268/TumorCenter_CD3_block13_x1_y4_patient268_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4947.4, + "Centroid Y µm": 15766.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/268/TumorCenter_CD3_block13_x2_y4_patient268_1.json b/268/TumorCenter_CD3_block13_x2_y4_patient268_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d5cb94f0e9e27bebed67416cc455a9e3a89f622 --- /dev/null +++ b/268/TumorCenter_CD3_block13_x2_y4_patient268_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7571.0, + "Centroid Y µm": 15941.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/268/TumorCenter_CD8_block13_x1_y4_patient268_0.json b/268/TumorCenter_CD8_block13_x1_y4_patient268_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be49cc81f18a917687e5fa21ed9bd2ceca5915c6 --- /dev/null +++ b/268/TumorCenter_CD8_block13_x1_y4_patient268_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 11269.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/268/TumorCenter_CD8_block13_x2_y4_patient268_1.json b/268/TumorCenter_CD8_block13_x2_y4_patient268_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f6e25b4dfa9334f6243ebdc9e1350e3fd7d2258f --- /dev/null +++ b/268/TumorCenter_CD8_block13_x2_y4_patient268_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 10944.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/268/history_text.txt b/268/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/268/icd_codes.txt b/268/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..622644b35931717c96ba26ff3b122113f06cc84b --- /dev/null +++ b/268/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/268/ops_codes.txt b/268/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c6feac3e58408025345415108364f7462ce392c2 --- /dev/null +++ b/268/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie mit Rekonstruktion mit lokaler Schleimhaut[5-295.11 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Einlegen einer Stimmprothese[5-319.9 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/268/patient_clinical_data.json b/268/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b19da48492a7f36cce0b8146d18ffb64bbf8267a --- /dev/null +++ b/268/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/268/patient_pathological_data.json b/268/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e47d7f158aff0a1a3bf68d0f3a400d0bf72b8f16 --- /dev/null +++ b/268/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "268", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 44, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 21.0 +} \ No newline at end of file diff --git a/268/surgery_description.txt b/268/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b331e00da1e76a8d2ef57e47e75d0357e43ee8ab --- /dev/null +++ b/268/surgery_description.txt @@ -0,0 +1 @@ +Partial pharyngectomy with laryngectomy, Bilateral neck dissection, Tracheotomy, Provox diff --git a/268/surgery_report.txt b/268/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..056955982f4d28c12b50b2a66109437489021d72 --- /dev/null +++ b/268/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthetist. An attempt is first made to intubate bronchoscopically. This is not possible due to the large tumor masses. The bronchoscope cannot pass through the tumor masses and the glottis. Therefore withdrawal and decision for tracheotomy in LA. Ultracaine is injected in the tracheotomy area. Then a skin incision is made slightly below the cricoid cartilage, dissected in depth down to the prelaryngeal muscles. This is pushed to the side. Then dissection down to the thyroid gland. Exposure of the thyroid gland. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus. Exposure of the anterior wall of the trachea and entry into the trachea between the 2nd and 3rd tracheal cartilage. Insertion of a laryngectomy tube and repositioning in preparation for surgery. Then sterile washing and draping. Creation of an apron flap in the usual manner, while protecting the platysma. Start with neck dissection/tumor resection on the left side. This reveals a very large metastasis that initially appears to be attached to the larynx and merges into the tumor per continuitatem. This metastasis is first detached from the cervical vascular sheath. It can be seen that the internal jugular vein runs directly into the metastasis. This must be cut off. The common carotid artery, the external carotid artery and the internal carotid artery can be detached from the metastasis, as can the vagus nerve. Most of the sternocleidomastoid muscle must also be removed, but the outer layers of the muscle can be preserved and the accessorius nerve also preserved, as there is clearly no tumor infiltration here. Exposure of the hyoid bone. Then release of the larynx and detachment of the cervical vascular sheath, also on the right side. Detachment of the suprahyoid muscles from the hyoid bone and opening of the pharynx at the exact point of the epiglottis. Pull out the epiglottis and incise the pharynx downwards along the free edge of the epiglottis. The tumor can be easily palpated macroscopically and the tumor is resected up to the posterior side of the pharynx, leaving a sufficient safety margin in the pharynx. Then release the piriform sinus on the right side and complete the tumor resection and laryngectomy by cutting around the pharynx and piriform sinus from the opposite side. Then the laryngeal preparation is also removed posteriorly below the cricoid cartilage so that a good tongue-shaped flap can remain on the posterior wall of the trachea. Now demonstrate the entire preparation on and also on . It is recommended not to perform a flapplasty as sufficient mucosal tissue is present. Due to the good safety distance, it is possible to take margin samples directly from the specimen without any problems. The specimen is completely covered by margin samples and cut around. The pathologist classifies everything in the frozen section as R0. Then insertion of a voice valve prosthesis in the usual manner by creating a tracheoesophageal fistula using the trocar provided for this purpose. The voice valve prosthesis is then inserted using the pull-through method and the edges are carefully rolled out. The Provox prosthesis is positioned approx. 1 cm below the tracheostoma. Now perform the pharyngeal suture in the usual way, starting at the top at the base of the tongue. Then switch to the distal area and place the 1st suture, then place the 2nd suture. Then complete the neck dissection in level V on the left side. Then perform the modified radical neck dissection on the right side levels II to IV using . For this, the sternocleidomastoid muscle is further released, the accessorius is exposed, the hypoglossus is exposed, the neck preparation is released from the neck vessel sheath and removed. Now perform the 3rd safety suture, fixation of the constrictor pharyngeal muscle. Finally, incision and completion of the tracheostoma with formation of a mucocutaneous anastomosis. Two Redon drains were inserted and a two-layer wound closure was made. Please X-ray pap smear examination after 10 days, then, if there is no fistula, problem-free, step-by-step diet reconstruction and presentation of the patient to the tumor conference to plan adjuvant therapy. \ No newline at end of file diff --git a/269/InvasionFront_CD3_block8_x5_y10_patient269_0.json b/269/InvasionFront_CD3_block8_x5_y10_patient269_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7c4812b5d0c9cc8e1e31c7156c75f1fc874f3938 --- /dev/null +++ b/269/InvasionFront_CD3_block8_x5_y10_patient269_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 35356.3, + "Num Detections": 16177, + "Num Negative": 16145, + "Num Positive": 32, + "Positive %": 0.1978, + "Num Positive per mm^2": 18.45 + } +} \ No newline at end of file diff --git a/269/InvasionFront_CD3_block8_x6_y10_patient269_1.json b/269/InvasionFront_CD3_block8_x6_y10_patient269_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3aeff00ad66cfc2afd079a74aa96d84013a87c9f --- /dev/null +++ b/269/InvasionFront_CD3_block8_x6_y10_patient269_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19114.9, + "Centroid Y µm": 35306.3, + "Num Detections": 20539, + "Num Negative": 20480, + "Num Positive": 59, + "Positive %": 0.2873, + "Num Positive per mm^2": 25.96 + } +} \ No newline at end of file diff --git a/269/InvasionFront_CD8_block8_x5_y10_patient269_0.json b/269/InvasionFront_CD8_block8_x5_y10_patient269_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ab4c6f19182ee95aca82430b85f2be0c337e3a0f --- /dev/null +++ b/269/InvasionFront_CD8_block8_x5_y10_patient269_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 25961.3, + "Num Detections": 17516, + "Num Negative": 17190, + "Num Positive": 326, + "Positive %": 1.861, + "Num Positive per mm^2": 168.42 + } +} \ No newline at end of file diff --git a/269/InvasionFront_CD8_block8_x6_y10_patient269_1.json b/269/InvasionFront_CD8_block8_x6_y10_patient269_1.json new file mode 100644 index 0000000000000000000000000000000000000000..075d7deed71673b613a51e6282d8c81680e0ead3 --- /dev/null +++ b/269/InvasionFront_CD8_block8_x6_y10_patient269_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 26111.2, + "Num Detections": 20453, + "Num Negative": 19986, + "Num Positive": 467, + "Positive %": 2.283, + "Num Positive per mm^2": 210.26 + } +} \ No newline at end of file diff --git a/269/TumorCenter_CD3_block8_x5_y10_patient269_0.json b/269/TumorCenter_CD3_block8_x5_y10_patient269_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0f357afce6f044ba41b873b6e92fd1ba4d630b24 --- /dev/null +++ b/269/TumorCenter_CD3_block8_x5_y10_patient269_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18165.4, + "Centroid Y µm": 25686.4, + "Num Detections": 16632, + "Num Negative": 16589, + "Num Positive": 43, + "Positive %": 0.2585, + "Num Positive per mm^2": 22.82 + } +} \ No newline at end of file diff --git a/269/TumorCenter_CD3_block8_x6_y10_patient269_1.json b/269/TumorCenter_CD3_block8_x6_y10_patient269_1.json new file mode 100644 index 0000000000000000000000000000000000000000..336c72aa5c98f9f951919c1e43a69ef2a1817128 --- /dev/null +++ b/269/TumorCenter_CD3_block8_x6_y10_patient269_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20614.1, + "Centroid Y µm": 25386.6, + "Num Detections": 15192, + "Num Negative": 15063, + "Num Positive": 129, + "Positive %": 0.8491, + "Num Positive per mm^2": 71.79 + } +} \ No newline at end of file diff --git a/269/TumorCenter_CD8_block8_x5_y10_patient269_0.json b/269/TumorCenter_CD8_block8_x5_y10_patient269_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42d5f412aada2f22c225410c6bad1e6239204b87 --- /dev/null +++ b/269/TumorCenter_CD8_block8_x5_y10_patient269_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17465.8, + "Centroid Y µm": 25136.7, + "Num Detections": 20655, + "Num Negative": 20296, + "Num Positive": 359, + "Positive %": 1.738, + "Num Positive per mm^2": 169.03 + } +} \ No newline at end of file diff --git a/269/TumorCenter_CD8_block8_x6_y10_patient269_1.json b/269/TumorCenter_CD8_block8_x6_y10_patient269_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eea47da49d012333d58422dfb651bc35c4bc00c4 --- /dev/null +++ b/269/TumorCenter_CD8_block8_x6_y10_patient269_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19914.5, + "Centroid Y µm": 24986.8, + "Num Detections": 20778, + "Num Negative": 20353, + "Num Positive": 425, + "Positive %": 2.045, + "Num Positive per mm^2": 188.7 + } +} \ No newline at end of file diff --git a/269/history_text.txt b/269/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/269/icd_codes.txt b/269/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/269/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/269/ops_codes.txt b/269/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cfb1b669852f3313b320eb8967a8bcb0cfda77c5 --- /dev/null +++ b/269/ops_codes.txt @@ -0,0 +1 @@ +Pharyngotomie: Lateral[5-290.3 ] Pharyngoplastik: Mit gestieltem myokutanen Lappen[5-293.1 ] Partielle Resektion des Pharynx [Pharynxteilresektion]: Durch Pharyngotomie: Rekonstruktion mit gestieltem regionalen Lappen[5-295.12 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 B] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Permanente Tracheostomie: Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/269/patient_clinical_data.json b/269/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c00dc07847776503c77b4aa7ced3e6643ae71f83 --- /dev/null +++ b/269/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/269/patient_pathological_data.json b/269/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..75e6855998912ec64845cee4a316f8b57c43c9c1 --- /dev/null +++ b/269/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "269", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/269/surgery_description.txt b/269/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ddd598eaf134fb61341096f63cbdb296f78c5642 --- /dev/null +++ b/269/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Partial pharyngeal resection, Bilateral neck dissection, Reconstruction, Pedicled flap (Platysma), PEG placement, Tracheotomy diff --git a/269/surgery_report.txt b/269/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed842cf77293bb8d649f4a37f74c1423a66c8d64 --- /dev/null +++ b/269/surgery_report.txt @@ -0,0 +1 @@ +Pharyngoscopy performed again before the start of the operation: insertion of the small bore tube. As described above, an approx. 3 x 2 cm large mass can be seen in the right hypopharynx, which was positively biopsied as a squamous cell carcinoma. The tumor appears to be resectable by lateral pharyngotomy. The PEG is now initially inserted: the esophagoscope is inserted into the stomach. Due to the thickness of the subcutaneous layer, conditions are much more difficult. Nevertheless, a clear diaphanoscopy can now be seen when pressure is applied with the finger. Clear conditions under sonographic control. No liver or intestinal loops in the abdominal wall. Placement of the PEG with the thread pull-through method in the usual way. No bleeding. Primary wound dressing on the abdomen. Intraoperative administration of 250 mg SDH. Now infiltration anesthesia in the area of the right neck. First incision of a platysmal flap and careful dissection of the platysma further cranially. The sternocleidomastoid muscle is also exposed in depth. Further dissection of the platysmal flap over the submandibular gland in a cranial direction. Now dissection of the internal jugular vein and facial vein in depth. Very difficult dissection conditions. A large metastasis infiltrates the sternocleidomastoid muscle. For this reason, part of the muscle must be sharply separated from the metastasis. Finally, the internal jugular vein can be freed from the metastasis. Deep dissection of the vagus nerve and the external and internal carotid arteries as well as the accessorius nerve. Expose the posterior digastric venter muscle. Now complete the posterior neck by clearing out the accessorius triangle and dissecting the mass caudally to supraclavicular. Separate the soft tissue there and cut around it. Finally, dissection of the venous angle. Exposure of the hypoglossal nerve. Removal of the capsule of the submandibular gland. The previously described metastasis is now also completely separated from the facial vein. The vein remains intact. Dissection of the superior thyroid artery and completion of the neck preparation on the right with removal of all soft tissue and lymph nodes. Now proceed to the left. Here too, skin incision at the anterior edge of the sternocleidomastoid muscle. Dissection of the muscle in depth after cutting through the subcutaneous tissue and platysma. Exposure of the internal jugular vein and the external and internal carotid arteries as well as the vagus nerve. Exposure of the accessorius nerve and the posterior digastric venter muscle. Now dissect the posterior neck preparation from cranial to caudal. Protect the cervical plexus. Set down caudally after repositioning. Now dissect the submandibular gland. Remove the capsule. Dissection of the hypoglossal nerve and completion of the neck preparation anteriorly, including the capsule of the submandibular gland and the soft tissue in front of and above the common carotid artery. Perform the tracheotomy. Median skin incision for this. Dissection of the subcutaneous tissue and the infrahyoid musculature. Difficult dissection conditions due to the very deep larynx. Exposure of the thyroid isthmus. Undermining, cutting through and perforating it. Exposure of the cricoid cartilage. Insertion between the 1st and 2nd tracheal cartilage. Creation of a Björk flap and epithelialization of the tracheostoma. Relatively high tension due to the deep trachea. Re-intubation of the patient. Now turn back to the tumor side on the right and skeletonize the larynx on the right side or the thyroid cartilage. Enter the pharynx. The tumor becomes visible. This is also clinically incised in healthy tissue. It reaches up to the arytenoid cusp. Extremely difficult dissection conditions here. It is finally possible to resect the entire tumor from cranial to caudal, including part of the larynx and half of the thyroid cartilage on the right. Removal of marginal samples. These are found to be tumor-free. Extensive hemostasis with H2O2 and bipolar coagulation. Now perform the pharyngeal suture. The previously prepared platysmal flap is not required. Primary wound closure can be performed. Invert the sutures from caudal to cranial. Multi-layer wound closure. Mobilize the right thyroid gland and suture the thyroid gland over the pharyngeal suture again. Extensive hemostasis in the area of the right neck. Irrigation with H2O2. Irrigation with H2O2 and NaCl on the left side as well. No more bleeding. Insertion of a Redon drain on the left and right side. Subcutaneous sutures, skin sutures and wound dressing. The platysmal flap is resected and primary skin closure can be achieved on the right side by adapting the wound edges. Finally, an 8-gauge Rügheimer cannula is inserted again. The patient goes to the intensive care unit extubated or awake for monitoring. Further administration of Unacid over the next few days. No bleeding at the end of the operation, no other special features. The tumor and the neck specimen on both sides are sent for definitive histology. \ No newline at end of file diff --git a/270/InvasionFront_CD3_block18_x5_y7_patient270_0.json b/270/InvasionFront_CD3_block18_x5_y7_patient270_0.json new file mode 100644 index 0000000000000000000000000000000000000000..efdf3f3b8b10250472a25569b88adb1b164b5540 --- /dev/null +++ b/270/InvasionFront_CD3_block18_x5_y7_patient270_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 22563.1, + "Num Detections": 16454, + "Num Negative": 15314, + "Num Positive": 1140, + "Positive %": 6.928, + "Num Positive per mm^2": 592.52 + } +} \ No newline at end of file diff --git a/270/InvasionFront_CD3_block18_x6_y7_patient270_1.json b/270/InvasionFront_CD3_block18_x6_y7_patient270_1.json new file mode 100644 index 0000000000000000000000000000000000000000..221c3b48a4ba4fc275f46e45ec265bb365bb2123 --- /dev/null +++ b/270/InvasionFront_CD3_block18_x6_y7_patient270_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 22787.9, + "Num Detections": 16211, + "Num Negative": 15336, + "Num Positive": 875, + "Positive %": 5.398, + "Num Positive per mm^2": 452.67 + } +} \ No newline at end of file diff --git a/270/InvasionFront_CD8_block18_x5_y7_patient270_0.json b/270/InvasionFront_CD8_block18_x5_y7_patient270_0.json new file mode 100644 index 0000000000000000000000000000000000000000..04a8dc81052c3de37c3c7e67fee05712de83b2e0 --- /dev/null +++ b/270/InvasionFront_CD8_block18_x5_y7_patient270_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 25236.6, + "Num Detections": 16393, + "Num Negative": 15510, + "Num Positive": 883, + "Positive %": 5.386, + "Num Positive per mm^2": 480.44 + } +} \ No newline at end of file diff --git a/270/InvasionFront_CD8_block18_x6_y7_patient270_1.json b/270/InvasionFront_CD8_block18_x6_y7_patient270_1.json new file mode 100644 index 0000000000000000000000000000000000000000..62e14052942ae3826d560cf789ed4794c29757c1 --- /dev/null +++ b/270/InvasionFront_CD8_block18_x6_y7_patient270_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 25061.7, + "Num Detections": 13704, + "Num Negative": 13063, + "Num Positive": 641, + "Positive %": 4.677, + "Num Positive per mm^2": 353.75 + } +} \ No newline at end of file diff --git a/270/TumorCenter_CD3_block18_x5_y7_patient270_0.json b/270/TumorCenter_CD3_block18_x5_y7_patient270_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3b7f669857311fd5fa2ed317a71b9a82dbadbf4e --- /dev/null +++ b/270/TumorCenter_CD3_block18_x5_y7_patient270_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 17066.0, + "Num Detections": 16153, + "Num Negative": 15615, + "Num Positive": 538, + "Positive %": 3.331, + "Num Positive per mm^2": 295.06 + } +} \ No newline at end of file diff --git a/270/TumorCenter_CD3_block18_x6_y7_patient270_1.json b/270/TumorCenter_CD3_block18_x6_y7_patient270_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eb8e1d7b3c5edd6855e85aa18e9623cee1494a3d --- /dev/null +++ b/270/TumorCenter_CD3_block18_x6_y7_patient270_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 17140.9, + "Num Detections": 17604, + "Num Negative": 17078, + "Num Positive": 526, + "Positive %": 2.988, + "Num Positive per mm^2": 283.38 + } +} \ No newline at end of file diff --git a/270/TumorCenter_CD8_block18_x5_y7_patient270_0.json b/270/TumorCenter_CD8_block18_x5_y7_patient270_0.json new file mode 100644 index 0000000000000000000000000000000000000000..038345f91ccc4505de36ffcefba5fe98dcce6415 --- /dev/null +++ b/270/TumorCenter_CD8_block18_x5_y7_patient270_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15666.7, + "Centroid Y µm": 17890.5, + "Num Detections": 16328, + "Num Negative": 15709, + "Num Positive": 619, + "Positive %": 3.791, + "Num Positive per mm^2": 335.09 + } +} \ No newline at end of file diff --git a/270/TumorCenter_CD8_block18_x6_y7_patient270_1.json b/270/TumorCenter_CD8_block18_x6_y7_patient270_1.json new file mode 100644 index 0000000000000000000000000000000000000000..33757cb55c835236a1d85cf71d43b290b5f22a04 --- /dev/null +++ b/270/TumorCenter_CD8_block18_x6_y7_patient270_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18115.4, + "Centroid Y µm": 18015.5, + "Num Detections": 15975, + "Num Negative": 15342, + "Num Positive": 633, + "Positive %": 3.962, + "Num Positive per mm^2": 343.24 + } +} \ No newline at end of file diff --git a/270/history_text.txt b/270/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6e7fb2938ca1c0e5ad671db6a027eb7eba520928 --- /dev/null +++ b/270/history_text.txt @@ -0,0 +1 @@ +Patient with post induction chemotherapy for hypopharyngeal carcinoma with infiltration of the left larynx. No significant reduction of the tumor during the course, therefore pharyngoscopy and laryngoscopy again before surgery. \ No newline at end of file diff --git a/270/icd_codes.txt b/270/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..739d9698e26651477346fcfa3195fb70564f6265 --- /dev/null +++ b/270/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] \ No newline at end of file diff --git a/270/ops_codes.txt b/270/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5d5ca58074f6a2058a61305ad269853a2b29ad9c --- /dev/null +++ b/270/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/270/patient_clinical_data.json b/270/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..901a26d0087ac98c94f8f7c45de87b55bc6447e0 --- /dev/null +++ b/270/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 62, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 49, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/270/patient_pathological_data.json b/270/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..55ed258680d80d11406b68a80d576f1da7b6c083 --- /dev/null +++ b/270/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "270", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.5 +} \ No newline at end of file diff --git a/270/surgery_description.txt b/270/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b53c05f8f1014a874efbd77c6fa62fb2d0aa550 --- /dev/null +++ b/270/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, Tracheostomy creation diff --git a/270/surgery_report.txt b/270/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2027c88ab55258024c69bf3cf0ca41a4e641ffb5 --- /dev/null +++ b/270/surgery_report.txt @@ -0,0 +1 @@ +Start of the operation by tracheotomy. For this purpose, approx. 3 cm horizontal skin incision below the cricoid cartilage. Cut through the skin of the subcutis. Identification of the infralaryngeal muscles and separation in the midline. Separation of the muscle bellies and identification of the thyroid isthmus. Undermining of the thyroid isthmus with the clamp and bipolar coagulation of the isthmus as well as isthmus splitting. Now identification of the anterior tracheal wall and entry into the 3rd intertracheal ring space by means of a visor tracheotomy. Insertion of an 8 mm tube. Now draw in the apron flap. This runs on both sides along the anterior edge of the sternocleidomastoid muscle to the mastoid (2 QF) below the mandible. Now cut the cutaneous and subcutaneous tissue on both sides. Separation of the platysma. Subplatysmal dissection of the apron flap in the usual manner and slinging using 3 sutures. Now pharyngoscopy and laryngoscopy again: positioning of the patient. Insertion of the Kleinsasser tube. The tumor can be seen on the left, which passes from the arytenoid cartilage via the aryepiglottic fold to the piriform sinus and onto the hypopharyngeal side wall up to the cranial vallecula. Base of tongue not infiltrated macroscopically. Overall indication for laryngectomy with partial pharyngectomy, if necessary with flap coverage. Sterile draping and injection of a total of 10 ml Ultracaine 1% with adrenaline into both sides of the neck follows. Then lift an apron flap in the typical manner up to the submandibular gland on both sides and subplatysmal at the level of the hyoid bone. Then neck dissection on the left: Exposure of the sternocleidomastoid muscle, omohyoid muscle and digastric muscle. Exposure of the internal jugular vein, facial vein and external and internal carotid arteries. Exposure of the accessory nerve, glossopharyngeal nerve and vagus nerve. Clearing level II to V. Here also visualization and preservation of the branches of the cervical plexus. Macroscopically no clear evidence of lymph node involvement. Subsequent right neck dissection Level II to V: Identification and visualization of the anterior border of the sternocleidomastoid muscle and dissection down to depth. Identification of the omohyoid muscle. Dissection along the omohyoid muscle up to the hyoid bone. Now cranial identification of the digastric muscle and detachment of the submandibular gland from the glandular capsule. Now identify the accessorius nerve. The nerve is safely spared and dissected free from the neck preparation. Also identification of the hypoglossal nerve. Sharp dissection along the V. jugularis interna and lateral tapping of the neck preparation. Now free the cervical vascular nerve sheath from the neck preparation. The carotid artery, vagus nerve and jugular vein must be safely identified and protected. Now remove the neck preparation in the usual manner from cranial to caudal while sparing the deep plexus branches. Completion of the neck dissection on the right side without complications. Subsequent laryngectomy with partial pharyngectomy: first exposing the hyoid bone and separating it from the suprahyoid musculature. Pre-epiglottic fatty tissue is included in the resection. Exposure of the left superior cornu and exposure of the laryngeal skeleton. Hypopharynx remains on the laryngeal skeleton. Caudal dissection of the thyroid gland. Subsequent isolation of the right superior cornu, dissection of the hypopharynx from the laryngeal skeleton. Caudal dissection of the thyroid gland. Subsequent entry into the larynx, initially from the right paramedian side. Exposure of the tumor. Cut around the tumor macroscopically with a safety margin of at least 1 to 1.5 cm. The larynx is integrated into the resection. Caudal dissection of the larynx from the distal hypopharynx or esophageal entrance. Deposition of the larynx above the tracheostoma. Prior to this, preparation of a mucosal flap from the cricoid cartilage, which is dissected off here and sutured to the tracheal cartilage remaining cranial to the tracheostoma. This creates a Hermann ridge. Sutures with 3 or 4-0 Vicryl. The larynx is marked with sutures. In the area from the middle of the base of the tongue to the left pharyngeal wall, a further marginal sample is obtained and also marked with sutures; this is sent to the frozen section. The frozen section still shows carcinoma in situ infiltrates in the area of the middle of the tongue base and moderate dysplasia in the area of the left pharyngeal wall. Therefore, another 1 cm resection was taken from the base of the tongue, which extended to the left pharyngeal wall. No more infiltrates in the tumor-free part in the frozen section. However, there is still moderate dysplasia at several edges, no further surgical measures in the case of suspected field carcinomatization. Myotomy on the left in the typical manner and insertion of a size 8 provox prosthesis in the typical manner. Subsequent suturing of the hypopharynx, partly continuous, partly inverting single button sutures. Subsequently 2nd suture inverted over the 1st suture. Further inverting sutures are made, particularly in the area of the base of the tongue. Then 3rd suture of the musculature over the 2nd suture, also with Vicryl 4-0 single button sutures. A gastric tube was inserted as a splint before pharyngeal closure. Subsequently, careful irrigation of the wound area with hemostasis and layered wound closure with insertion of a Redon drainage in both sides of the neck. The tracheostoma was also epithelialized. Subsequent completion of the procedure without complications. Patient received preoperative antibiotics with Unacid. Please continue this antibiotic treatment for one week. Feeding via PEG tube for approx. 12 days, then carefully build up diet after swallowing porridge. Presentation at the interdisciplinary tumor conference after receipt of the final histology. Due to the moderate dysplasia and suspected field carcinomatization, discuss radiotherapy postoperatively. \ No newline at end of file diff --git a/271/InvasionFront_CD8_block3_x1_y11_patient271_0.json b/271/InvasionFront_CD8_block3_x1_y11_patient271_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9141935a4bdcb47e130cce9bfb5fa8445baa5103 --- /dev/null +++ b/271/InvasionFront_CD8_block3_x1_y11_patient271_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5000.0, + "Centroid Y µm": 27070.2, + "Num Detections": 16140, + "Num Negative": 15538, + "Num Positive": 602, + "Positive %": 3.73, + "Num Positive per mm^2": 293.37 + } +} \ No newline at end of file diff --git a/271/InvasionFront_CD8_block3_x2_y11_patient271_1.json b/271/InvasionFront_CD8_block3_x2_y11_patient271_1.json new file mode 100644 index 0000000000000000000000000000000000000000..91fd93c80768f5f617178049fd328f58cac2ee5f --- /dev/null +++ b/271/InvasionFront_CD8_block3_x2_y11_patient271_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7587.4, + "Centroid Y µm": 27178.7, + "Num Detections": 12423, + "Num Negative": 12230, + "Num Positive": 193, + "Positive %": 1.554, + "Num Positive per mm^2": 92.84 + } +} \ No newline at end of file diff --git a/271/TumorCenter_CD3_block3_x1_y11_patient271_0.json b/271/TumorCenter_CD3_block3_x1_y11_patient271_0.json new file mode 100644 index 0000000000000000000000000000000000000000..62a12a4ca4ee272fd429b42f2fe0a7e63b148610 --- /dev/null +++ b/271/TumorCenter_CD3_block3_x1_y11_patient271_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3173.3, + "Centroid Y µm": 33532.2, + "Num Detections": 9091, + "Num Negative": 8077, + "Num Positive": 1014, + "Positive %": 11.15, + "Num Positive per mm^2": 840.18 + } +} \ No newline at end of file diff --git a/271/TumorCenter_CD3_block3_x2_y11_patient271_1.json b/271/TumorCenter_CD3_block3_x2_y11_patient271_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1563490f3fa9135e6a445de19f7c295e877f676b --- /dev/null +++ b/271/TumorCenter_CD3_block3_x2_y11_patient271_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5972.6, + "Centroid Y µm": 33634.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/271/TumorCenter_CD8_block3_x1_y11_patient271_0.json b/271/TumorCenter_CD8_block3_x1_y11_patient271_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1c33b14482b7b5cc0d4e54389d3393189e933e6b --- /dev/null +++ b/271/TumorCenter_CD8_block3_x1_y11_patient271_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3473.2, + "Centroid Y µm": 27610.4, + "Num Detections": 15496, + "Num Negative": 15349, + "Num Positive": 147, + "Positive %": 0.9486, + "Num Positive per mm^2": 69.08 + } +} \ No newline at end of file diff --git a/271/TumorCenter_CD8_block3_x2_y11_patient271_1.json b/271/TumorCenter_CD8_block3_x2_y11_patient271_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d72d1cc68ea880bdb314819b808effe41fd88865 --- /dev/null +++ b/271/TumorCenter_CD8_block3_x2_y11_patient271_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 27960.2, + "Num Detections": 16605, + "Num Negative": 16568, + "Num Positive": 37, + "Positive %": 0.2228, + "Num Positive per mm^2": 17.13 + } +} \ No newline at end of file diff --git a/271/history_text.txt b/271/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..90433584514903f999b5ee78b7b80fd8104f9f0e --- /dev/null +++ b/271/history_text.txt @@ -0,0 +1 @@ +The patient has been suffering from pain in the left tongue area for several months. There is a history of alcohol and nicotine abuse. A sample was taken in the panendoscopy <2016>. This revealed a P16 negative G3 squamous cell carcinoma. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/271/icd_codes.txt b/271/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/271/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/271/ops_codes.txt b/271/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fac7362f59c6bd84a4313ef644ed2e2a204ed468 --- /dev/null +++ b/271/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Exstirpation total transoral (erkrankter) harter und weicher Gaumen[5-272.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Inzision Zungengrund[5-250.x ] Sonstige Glossektomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-252.x2 ] Spalthaut auf granulierendes Hautareal großflächig Empfängerstelle sonstige[5-902.5x L] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/271/patient_clinical_data.json b/271/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5a56f6fd5fefb5fb162b5750f2f1510a3ad40653 --- /dev/null +++ b/271/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 42, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/271/patient_pathological_data.json b/271/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7254c0300f257a04ff2522cc371670fc3dbbab12 --- /dev/null +++ b/271/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "271", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 18.0 +} \ No newline at end of file diff --git a/271/surgery_description.txt b/271/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2b5f76b5e679d2bba7294c357bab450b835835dc --- /dev/null +++ b/271/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Reconstruction, Free flap (Radial) diff --git a/271/surgery_report.txt b/271/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..74aff8d62d1bd40ea1074000110fa6f2f1efabf1 --- /dev/null +++ b/271/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesiology colleagues, then the PEG is inserted first. For this purpose, the flexible oesophagogastroscope is used to enter the stomach. The mucosa is unremarkable. If the diaphanoscopy is good, the PEG is inserted using the thread pull-through method without complications. Repositioning and insertion of the spandex and a covered wound blocker. Inspection of the tumor region. The tumor is located in the area of the glossotonsillar groove on the left, merges into the base of the tongue, merges onto the alveolar ridge of the lower jaw and merges into the lateral floor of the mouth. Now snare the tongue and start resecting the tumor in the tongue area with the monopolar needle. The tumor is cut around the edge of the tongue up to the base of the tongue. The tumor is then cut around in the area of the floor of the mouth and the side wall of the pharynx. Then push the tumor away from the lower jaw in the area of the alveolar ridge. This was successful without any problems. Extension of the resection in the area of the glossotonsillar groove. Although the mouth opening is very small, it is possible to resect the tumor completely transorally with maximum relaxation and opening of the mouth. The tumor is retrieved en bloc. Subsequent resections are performed in the area where the tumor is macroscopically close to the resection margins. At the end, marginal samples are taken and the tumor specimen is sent in thread-marked. All marginal samples are free of tumor, carcinoma and dysplasia in the frozen section. Now measure the defect and proceed to neck dissection. At the same time, the radialis graft is lifted by and . Lifting of the radialis flap using and : Marking of the graft in the presence of . Skin incision along the previously defined flap boundaries and S-shaped skin incision into the antecubital fossa. Dissection through the subcutaneous tissue, initially in the area of the flap pedicle down to the forearm fascia. Identification of the superficial cutaneous veins. Identification of the cephalic vein and dissection of the vein. It can be seen that the vein can be included in the skin graft on the radial side. After inspecting the superficial venous situation, the forearm fascia is incised along the flexor carpi radialis muscle and the brachioradialis muscle in a distal direction. The forearm fascia is then incised in the area of the flap edges. In this case, the ulnar fascia is first dissected subfascially, leaving the peritendineum and perimysium of the adjacent muscles and tendons of the forearm intact. Identification of the ulnar artery. This can be left uninjured without any problems. Distal skin incision through the forearm fascia and subfascial dissection up to the anterior edge of the flexor carpi radialis muscle. Radial incision with inclusion of the cephalic vein in the graft. Here too, subfascial dissection is performed up to the anterior edge of the brachioradialis muscle. Particular care is taken here to preserve the superficial ramus of the radial nerve. Identification of the distal radial artery. Undermining of the radial artery with the clamp and clamping of the artery. After clamping the radial artery, there is no decrease in oxygen saturation (measured on the index finger). After approx. 5 minutes, the distal radial artery is severed and the stumps are supplied with a bypass ligature. The radial artery flap is now lifted from the depth alternately from the radial and ulnar side along the septum under constant bleeding control using the bipolar coagulation forceps and clip supply. After insertion of a proximal retractor between the muscle bellies of the .............................. carpi radialis and brachioradialis muscles, the flap pedicle is also dissected. The radial nerve can be spared here. The radial nerve can be spared. Dissection is carried out up to the confluence of the veins and up to the exit of the interosseous artery. The artery is also clamped with a clip for a few minutes. Here, too, there is no decrease in oxygen saturation (measured on the index finger). Once the interosseous artery has been ligated and ligated, the flap can be lifted without any problems. The wound is closed in two layers in the area of the S-shaped skin incision on the flap pedicle and split skin is sutured in the area of the former skin flap. The split skin is sutured in place with Ethilon 5.0 in single button sutures. Exposed tendons are covered with muscle tissue beforehand. Preparation swabs are attached to the split skin with deep skin sutures to fix the split skin graft to the substrate. This is followed by the application of a wound dressing with absorbent cotton and the application of a dorsal splint in a slightly extended position of the wrist as well as the application of a flexible bandage. Completion of flap elevation without complications. Start with neck dissection on the left side. Skin incision in a transverse skin fold. Exposure of the platysma. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the digastric muscle and the submandibular gland. Overall difficult preparation conditions as the neck is very voluminous and short. Exposure of the nervus accessorius and the cervical vascular sheath. The hypoglossal nerve and the lingual artery were already removed during the tumor resection. Now remove the neck specimen II a to V a while sparing the plexus branches. This causes the internal jugular vein to tear due to traction. This is carefully sutured over so that further flow is possible. As an anatomical variation, the facial vein emerges directly from the external jugular vein and the internal jugular vein has no further outlets in the area of the aforementioned level. Now remove the submandibular gland and clear level I b. Cut through the digastric muscle and create an enoral tunnel so that 3 transverse fingers can fit through. Now turn to the neck dissection on the opposite side. Here also skin incision in a transverse skin fold. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the digastric muscle and the submandibular gland. Then evacuation of neck levels II a to V a, sparing the plexus branches and hypoglossal nerve and the accessorius and cervical nerves. Here, too, the internal jugular vein is torn by hook traction. The entire venous tissue is extremely fragile. Unfortunately, it is not possible to close the tear of the internal jugular vein on the right side by suturing it over. Recall from . Ultimately, the internal jugular vein must be completely closed above an outlet and ligated. Then insertion of Tabotamp and completion of the neck dissection. Dissection of the superior thyroid artery and the facial vein and external jugular vein for flap connection. Removal of the radialis graft. It can be seen that although there is a good radial artery on the radialis graft itself, the venous situation is extremely critical. There are 2 tiny concomitant veins and a slender venous confluence between the superficial and deep system. In the end, the decision is made to use the radialis graft anyway. It is now sutured in place by placing sutures in the deep area of the oropharynx in the area of the base of the tongue and the side wall of the pharynx. The graft is then successively retracted and finally sutured in the area of the soft palate, the cheek and the anterior part of the edge of the tongue. The stalk is transferred to the right side and anastomosed with the superior thyroid artery and the facial vein and a further outlet from the facial vein. In the meantime, the tracheotomy was performed using the visor technique. At the end, a Redon drain was inserted on the left side and a flap on the right side. The patient went to the intensive care unit on a ventilator and was to continue antibiotics for at least 24 hours. The patient's diet should be resumed from the 14th postoperative day at the earliest. \ No newline at end of file diff --git a/272/InvasionFront_CD3_block22_x5_y10_patient272_0.json b/272/InvasionFront_CD3_block22_x5_y10_patient272_0.json new file mode 100644 index 0000000000000000000000000000000000000000..63c77139e8b475895ec803862d25521823471bc3 --- /dev/null +++ b/272/InvasionFront_CD3_block22_x5_y10_patient272_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 36855.5, + "Num Detections": 16452, + "Num Negative": 15914, + "Num Positive": 538, + "Positive %": 3.27, + "Num Positive per mm^2": 276.48 + } +} \ No newline at end of file diff --git a/272/InvasionFront_CD3_block22_x6_y10_patient272_1.json b/272/InvasionFront_CD3_block22_x6_y10_patient272_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dcf219c288073e1d7d824b6559b9b33e8d812068 --- /dev/null +++ b/272/InvasionFront_CD3_block22_x6_y10_patient272_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19564.6, + "Centroid Y µm": 36730.6, + "Num Detections": 19124, + "Num Negative": 18673, + "Num Positive": 451, + "Positive %": 2.358, + "Num Positive per mm^2": 212.54 + } +} \ No newline at end of file diff --git a/272/InvasionFront_CD8_block22_x5_y10_patient272_0.json b/272/InvasionFront_CD8_block22_x5_y10_patient272_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be0884369bca138fbdb23b910d5e072f9f98a75e --- /dev/null +++ b/272/InvasionFront_CD8_block22_x5_y10_patient272_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19514.7, + "Centroid Y µm": 24786.9, + "Num Detections": 13875, + "Num Negative": 13420, + "Num Positive": 455, + "Positive %": 3.279, + "Num Positive per mm^2": 264.34 + } +} \ No newline at end of file diff --git a/272/InvasionFront_CD8_block22_x6_y10_patient272_1.json b/272/InvasionFront_CD8_block22_x6_y10_patient272_1.json new file mode 100644 index 0000000000000000000000000000000000000000..67745e7e8aa1dcdbc5a3ca2539fb54f24c6c5d06 --- /dev/null +++ b/272/InvasionFront_CD8_block22_x6_y10_patient272_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 22338.2, + "Centroid Y µm": 24537.0, + "Num Detections": 19004, + "Num Negative": 18677, + "Num Positive": 327, + "Positive %": 1.721, + "Num Positive per mm^2": 155.55 + } +} \ No newline at end of file diff --git a/272/TumorCenter_CD3_block22_x5_y10_patient272_0.json b/272/TumorCenter_CD3_block22_x5_y10_patient272_0.json new file mode 100644 index 0000000000000000000000000000000000000000..226ea09ac8d6d19d701d83f7c3558bc7ecc11ffa --- /dev/null +++ b/272/TumorCenter_CD3_block22_x5_y10_patient272_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15816.6, + "Centroid Y µm": 25361.6, + "Num Detections": 16746, + "Num Negative": 16620, + "Num Positive": 126, + "Positive %": 0.7524, + "Num Positive per mm^2": 66.59 + } +} \ No newline at end of file diff --git a/272/TumorCenter_CD3_block22_x6_y10_patient272_1.json b/272/TumorCenter_CD3_block22_x6_y10_patient272_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd88b7c7670c14b006ef1db0281e54e46adb7021 --- /dev/null +++ b/272/TumorCenter_CD3_block22_x6_y10_patient272_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18365.3, + "Centroid Y µm": 25411.5, + "Num Detections": 16920, + "Num Negative": 16749, + "Num Positive": 171, + "Positive %": 1.011, + "Num Positive per mm^2": 89.0 + } +} \ No newline at end of file diff --git a/272/TumorCenter_CD8_block22_x5_y10_patient272_0.json b/272/TumorCenter_CD8_block22_x5_y10_patient272_0.json new file mode 100644 index 0000000000000000000000000000000000000000..90b23dab92e5833b3390a1bd5d461fc0698779c1 --- /dev/null +++ b/272/TumorCenter_CD8_block22_x5_y10_patient272_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18132.9, + "Centroid Y µm": 35185.5, + "Num Detections": 16106, + "Num Negative": 15770, + "Num Positive": 336, + "Positive %": 2.086, + "Num Positive per mm^2": 176.66 + } +} \ No newline at end of file diff --git a/272/TumorCenter_CD8_block22_x6_y10_patient272_1.json b/272/TumorCenter_CD8_block22_x6_y10_patient272_1.json new file mode 100644 index 0000000000000000000000000000000000000000..99019c83ea2ffd2ad465c746d3f907b484239d71 --- /dev/null +++ b/272/TumorCenter_CD8_block22_x6_y10_patient272_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20647.0, + "Centroid Y µm": 35133.6, + "Num Detections": 16572, + "Num Negative": 16243, + "Num Positive": 329, + "Positive %": 1.985, + "Num Positive per mm^2": 168.22 + } +} \ No newline at end of file diff --git a/272/history_text.txt b/272/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/272/icd_codes.txt b/272/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/272/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/272/ops_codes.txt b/272/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc397926da8578b4c3a09eb47fc1993c98594fb7 --- /dev/null +++ b/272/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Permanente Tracheotomie[5-312.0 ] PEG-Sonde Anlage[5-431.2 ] Anlage ösophagotracheale Fistel[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/272/patient_clinical_data.json b/272/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..88bd2d30d00efb44b150a64d59ad663afbdd4a51 --- /dev/null +++ b/272/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 75, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/272/patient_pathological_data.json b/272/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..732909463d1dbb0aa2580b6597dc2d171e32dd9e --- /dev/null +++ b/272/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "272", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/272/surgery_description.txt b/272/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d829b80a0044d100946db505c9bb993249cbaa89 --- /dev/null +++ b/272/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, Tracheotomy, PEG placement diff --git a/272/surgery_report.txt b/272/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..46f18e3d836a890e5934d598c785ee5c36e33115 --- /dev/null +++ b/272/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, attempt at intubation. This is not possible due to the tumor masses. Therefore quick decision to perform an emergency tracheotomy. Brief washing and injection of ultracaine mixture. Skin incision in the usual manner just below the inguinal cartilage. Rapid dissection in depth. Hemostasis by means of bipolar coagulation. Exposure of the thyroid gland. Undermining of the thyroid gland. Bipolar coagulation of the thyroid gland and transection of the isthmus. Exposure of the anterior wall of the trachea. Entering the trachea below the cricoid cartilage and intubation with a laryngectomy tube. Transfer for PEG insertion: insertion with the flexible oesophagoscope and pre-scanning into the stomach. If diaphanoscopy is good, perform the PEG insertion using the thread pull-through method. Enter with the small water tube and inspect the hypopharynx and larynx: The hypopharynx itself is unremarkable. Adjustment of the larynx. Here, an exophytic growing tumor can be seen on the right side with an inconspicuous epiglottis, which completely fills the endolarynx and extends to the other side. The vocal fold plane and pocket folds are no longer visible. The piriform sinus is free on both sides. Sterile washing and draping. Marking of the skin incision. Creation of an apron flap. The platysma is extremely thin and so is the skin. Exposure of the sternocleidomastoid muscle on the right side, the omohyoid muscle, the submandibular gland, the accessorius nerve, the hypoglossal nerve, exposure of the cervical vascular sheath. Free preparation of the internal jugular vein and excavation of neck levels II to V while sparing the plexus branches. Turning to the opposite side. Identical procedure. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland, accessorius nerve, lingual nerve. Exposure of the cervical vascular sheath. Dissection of the internal jugular vein and removal of the neck block II to V while sparing the plexus branches. Very little fatty tissue and no conspicuous lymph nodes are visible on either side. Level VI is integrated into the respective sides. Detachment of the cervical vascular sheath from the larynx. Skeletonization of the larynx with exposure of the hyoid bone and detachment of the infrahyal musculature. On the left side and in the middle, the musculature is left on the larynx preparation, as a thyroid cartilage perforation is described in the CT. Exposure of the upper horn of the thyroid cartilage on both sides and release of the piriform sinus. Enter the pharynx at the level of the hyoid bone and pull out the epiglottis. Cut along the edges of the epiglottis in a postcricoid direction while protecting the piriform sinus on both sides. Release of the postcricoid region and removal of the larynx below the cricoid cartilage. It can be clearly seen that the tumor does not extend far into the subglottic region and that the mucosa of the cricoid cartilage is inconspicuous at this point. To be on the safe side, a marginal sample was taken from the pharyngeal area at the pharyngo-epiglottic fold and sent in for a frozen section, as the resection margins were very narrow here. Pathology revealed no invasive carcinoma, no carcinoma in situ and no dysplasia. The esophageal myotomy was performed posteromedially on the left side so that a QF could be passed without any problems. Perform a myotomy on the sternocleidomastoid muscle on both sides to create a wide tracheostoma. Insertion of a Provox prosthesis 1 cm below the tracheostoma posterior edge in the usual manner. Incision of the tracheostoma initially at the front. Perform the pharyngeal suture in the usual manner. Fold back the apron flap and integrate it into the tracheostoma. Insertion of two Redon drains. Two-layer wound closure. The patient goes to the intensive care unit ventilated. Please carry out an X-ray pre-swallow 10 days postoperatively. Until then, the nasogastric tube remains in place as a splint. Unacid 1.5 g for 24 hours. \ No newline at end of file diff --git a/273/InvasionFront_CD3_block13_x1_y7_patient273_0.json b/273/InvasionFront_CD3_block13_x1_y7_patient273_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b249f1ea5dcbbdfe782f587d50b1edcd210492e --- /dev/null +++ b/273/InvasionFront_CD3_block13_x1_y7_patient273_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 16566.2, + "Num Detections": 15870, + "Num Negative": 14466, + "Num Positive": 1404, + "Positive %": 8.847, + "Num Positive per mm^2": 655.89 + } +} \ No newline at end of file diff --git a/273/InvasionFront_CD3_block13_x2_y7_patient273_1.json b/273/InvasionFront_CD3_block13_x2_y7_patient273_1.json new file mode 100644 index 0000000000000000000000000000000000000000..06e0b405986162f18f5f2922bfe77e299081f76a --- /dev/null +++ b/273/InvasionFront_CD3_block13_x2_y7_patient273_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 16566.2, + "Num Detections": 13457, + "Num Negative": 12167, + "Num Positive": 1290, + "Positive %": 9.586, + "Num Positive per mm^2": 623.78 + } +} \ No newline at end of file diff --git a/273/InvasionFront_CD8_block13_x1_y7_patient273_0.json b/273/InvasionFront_CD8_block13_x1_y7_patient273_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fabca1f19c6f7cfcfca1aa0c0f2da111145cb4d9 --- /dev/null +++ b/273/InvasionFront_CD8_block13_x1_y7_patient273_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4497.6, + "Centroid Y µm": 17865.5, + "Num Detections": 15810, + "Num Negative": 14261, + "Num Positive": 1549, + "Positive %": 9.798, + "Num Positive per mm^2": 691.12 + } +} \ No newline at end of file diff --git a/273/InvasionFront_CD8_block13_x2_y7_patient273_1.json b/273/InvasionFront_CD8_block13_x2_y7_patient273_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d467bcb91a25a885563f75ee3ceaa4fd40100a27 --- /dev/null +++ b/273/InvasionFront_CD8_block13_x2_y7_patient273_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7171.2, + "Centroid Y µm": 18015.5, + "Num Detections": 17397, + "Num Negative": 15426, + "Num Positive": 1971, + "Positive %": 11.33, + "Num Positive per mm^2": 898.59 + } +} \ No newline at end of file diff --git a/273/TumorCenter_CD3_block13_x1_y7_patient273_0.json b/273/TumorCenter_CD3_block13_x1_y7_patient273_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cf8fcba91dda62c28863c5af66313e824ffa9b5c --- /dev/null +++ b/273/TumorCenter_CD3_block13_x1_y7_patient273_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4497.6, + "Centroid Y µm": 23237.7, + "Num Detections": 15978, + "Num Negative": 14411, + "Num Positive": 1567, + "Positive %": 9.807, + "Num Positive per mm^2": 702.53 + } +} \ No newline at end of file diff --git a/273/TumorCenter_CD3_block13_x2_y7_patient273_1.json b/273/TumorCenter_CD3_block13_x2_y7_patient273_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5727ea91cd265712acc2fc4c5c92fd4550a16f41 --- /dev/null +++ b/273/TumorCenter_CD3_block13_x2_y7_patient273_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6921.3, + "Centroid Y µm": 23362.6, + "Num Detections": 10436, + "Num Negative": 8988, + "Num Positive": 1448, + "Positive %": 13.88, + "Num Positive per mm^2": 1010.4 + } +} \ No newline at end of file diff --git a/273/TumorCenter_CD8_block13_x1_y7_patient273_0.json b/273/TumorCenter_CD8_block13_x1_y7_patient273_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a49a61462390640e3f133360a9edb5139dda4898 --- /dev/null +++ b/273/TumorCenter_CD8_block13_x1_y7_patient273_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5047.3, + "Centroid Y µm": 18315.3, + "Num Detections": 15869, + "Num Negative": 14663, + "Num Positive": 1206, + "Positive %": 7.6, + "Num Positive per mm^2": 570.43 + } +} \ No newline at end of file diff --git a/273/TumorCenter_CD8_block13_x2_y7_patient273_1.json b/273/TumorCenter_CD8_block13_x2_y7_patient273_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8de3571b02e5adf119124b4c6e5761776e177bc9 --- /dev/null +++ b/273/TumorCenter_CD8_block13_x2_y7_patient273_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7421.1, + "Centroid Y µm": 18015.5, + "Num Detections": 9330, + "Num Negative": 8328, + "Num Positive": 1002, + "Positive %": 10.74, + "Num Positive per mm^2": 828.63 + } +} \ No newline at end of file diff --git a/273/history_text.txt b/273/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d8c29466b5efd430dfa92c368c8bc66f64579d4a --- /dev/null +++ b/273/history_text.txt @@ -0,0 +1 @@ +The patient is clinically suspected of having a tongue margin carcinoma on the left side. Condition after panendoscopy and PE <2019>. Sampling revealed a verrucous leukoplakia of the left tongue margin. The clinical diagnosis of carcinoma could not be confirmed during sampling. If the clinical suspicion remains high, there is now an indication for a generous biopsy. This procedure was discussed in detail with the patient. After being informed accordingly, the patient had ample opportunity to ask questions about the explained procedure. \ No newline at end of file diff --git a/273/icd_codes.txt b/273/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/273/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/273/ops_codes.txt b/273/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5d41b87681c1721c3ad6d0c4258888ac1abe0ac9 --- /dev/null +++ b/273/ops_codes.txt @@ -0,0 +1 @@ +Exzision erkranktes Gewebe Zunge[5-250.2 ] \ No newline at end of file diff --git a/273/patient_clinical_data.json b/273/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..73a030c4fa1ef2a3d7b239559c8629a424c6ebda --- /dev/null +++ b/273/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 66, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/273/patient_pathological_data.json b/273/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1dfbba7ca4e2561ddff50e6971641af5410a3884 --- /dev/null +++ b/273/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "273", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 11, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/273/surgery_description.txt b/273/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3259db6904743cab298859b273ebb71a542e625e --- /dev/null +++ b/273/surgery_description.txt @@ -0,0 +1 @@ +Wedge excision of tongue margin, Excisional biopsy diff --git a/273/surgery_report.txt b/273/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ffe1c1e0deae75612aabe19f23f07defcac01a2 --- /dev/null +++ b/273/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification and team time-out, anesthesia is induced by the anesthesia colleagues. Entry with the mouth guard while protecting the teeth. The tongue is then looped and the left edge of the tongue inspected. This reveals a large exulcerating, rather flat mass in the middle to posterior third of the tongue. First cut around a wedge with the scalpel. Then free dissection with scissors. Then hemostasis with bipolar forceps. The specimen is sent for intraoperative frozen section. The intraoperative frozen section revealed no evidence of malignancy. The decision was therefore made to perform an excisional biopsy. Incision of the findings with the electric needle. Subsequent hemostasis with bipolar forceps. Sending the specimen for final histology. Please wait for the final histology and, if necessary, present the case at our interdisciplinary tumor conference. \ No newline at end of file diff --git a/274/InvasionFront_CD3_block14_x1_y9_patient274_0.json b/274/InvasionFront_CD3_block14_x1_y9_patient274_0.json new file mode 100644 index 0000000000000000000000000000000000000000..04a1dfd99062e005ef58d8d396d1bbb5b605281f --- /dev/null +++ b/274/InvasionFront_CD3_block14_x1_y9_patient274_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 26111.2, + "Num Detections": 19167, + "Num Negative": 17887, + "Num Positive": 1280, + "Positive %": 6.678, + "Num Positive per mm^2": 559.71 + } +} \ No newline at end of file diff --git a/274/InvasionFront_CD3_block14_x2_y9_patient274_1.json b/274/InvasionFront_CD3_block14_x2_y9_patient274_1.json new file mode 100644 index 0000000000000000000000000000000000000000..51f25a9819d5feb0cdd077ca17978c849c240155 --- /dev/null +++ b/274/InvasionFront_CD3_block14_x2_y9_patient274_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 26211.1, + "Num Detections": 21901, + "Num Negative": 20239, + "Num Positive": 1662, + "Positive %": 7.589, + "Num Positive per mm^2": 711.84 + } +} \ No newline at end of file diff --git a/274/InvasionFront_CD8_block14_x1_y9_patient274_0.json b/274/InvasionFront_CD8_block14_x1_y9_patient274_0.json new file mode 100644 index 0000000000000000000000000000000000000000..05d1eeae8193df2291adbc83506060dff365b593 --- /dev/null +++ b/274/InvasionFront_CD8_block14_x1_y9_patient274_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4547.6, + "Centroid Y µm": 21838.4, + "Num Detections": 18394, + "Num Negative": 16895, + "Num Positive": 1499, + "Positive %": 8.149, + "Num Positive per mm^2": 702.72 + } +} \ No newline at end of file diff --git a/274/InvasionFront_CD8_block14_x2_y9_patient274_1.json b/274/InvasionFront_CD8_block14_x2_y9_patient274_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c39bf891a22ce471bc9ec7d48d9094f04c8f4aa7 --- /dev/null +++ b/274/InvasionFront_CD8_block14_x2_y9_patient274_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7096.2, + "Centroid Y µm": 21913.4, + "Num Detections": 22287, + "Num Negative": 20721, + "Num Positive": 1566, + "Positive %": 7.027, + "Num Positive per mm^2": 668.13 + } +} \ No newline at end of file diff --git a/274/TumorCenter_CD3_block14_x1_y9_patient274_0.json b/274/TumorCenter_CD3_block14_x1_y9_patient274_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2fc70455c728450c3c9de15ffddcb60d9925c56e --- /dev/null +++ b/274/TumorCenter_CD3_block14_x1_y9_patient274_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3748.0, + "Centroid Y µm": 22363.2, + "Num Detections": 18339, + "Num Negative": 16221, + "Num Positive": 2118, + "Positive %": 11.55, + "Num Positive per mm^2": 856.68 + } +} \ No newline at end of file diff --git a/274/TumorCenter_CD3_block14_x2_y9_patient274_1.json b/274/TumorCenter_CD3_block14_x2_y9_patient274_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f1f858d82eca2513e5724dd6b169acfdb35b4ccc --- /dev/null +++ b/274/TumorCenter_CD3_block14_x2_y9_patient274_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 22538.1, + "Num Detections": 19809, + "Num Negative": 18094, + "Num Positive": 1715, + "Positive %": 8.658, + "Num Positive per mm^2": 699.38 + } +} \ No newline at end of file diff --git a/274/TumorCenter_CD8_block14_x1_y9_patient274_0.json b/274/TumorCenter_CD8_block14_x1_y9_patient274_0.json new file mode 100644 index 0000000000000000000000000000000000000000..009e4c4dfc53e6c55865cab32a7c219b5a7b1987 --- /dev/null +++ b/274/TumorCenter_CD8_block14_x1_y9_patient274_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 22837.9, + "Num Detections": 19916, + "Num Negative": 17310, + "Num Positive": 2606, + "Positive %": 13.08, + "Num Positive per mm^2": 1058.7 + } +} \ No newline at end of file diff --git a/274/TumorCenter_CD8_block14_x2_y9_patient274_1.json b/274/TumorCenter_CD8_block14_x2_y9_patient274_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d89630bf38c151ed6f6400e9cbc1d46631476b70 --- /dev/null +++ b/274/TumorCenter_CD8_block14_x2_y9_patient274_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5946.9, + "Centroid Y µm": 22912.9, + "Num Detections": 21299, + "Num Negative": 19615, + "Num Positive": 1684, + "Positive %": 7.906, + "Num Positive per mm^2": 684.55 + } +} \ No newline at end of file diff --git a/274/history_text.txt b/274/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5f975981a6052d14b73f8e76857ce42852c0f788 --- /dev/null +++ b/274/history_text.txt @@ -0,0 +1 @@ +The patient has an outpatient histologically confirmed G2 squamous cell carcinoma of the underside of the tongue on the right, therefore indication for exclusion of another carcinoma in the head and neck region and excision of the histologically confirmed tumor. \ No newline at end of file diff --git a/274/icd_codes.txt b/274/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e12a190f84edfed8aa5de179304854081134b586 --- /dev/null +++ b/274/icd_codes.txt @@ -0,0 +1 @@ +Dorsales Zungenkarzinom[C02.0 R] \ No newline at end of file diff --git a/274/ops_codes.txt b/274/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7f01afdc662e901f9fd8bb0f44e8b31ca3c65378 --- /dev/null +++ b/274/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroduodenoskopie bei normalem Situs[1-632.0 ] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/274/patient_clinical_data.json b/274/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dad9a647f8052e52c750ccb7e4f2a2b560834993 --- /dev/null +++ b/274/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/274/patient_pathological_data.json b/274/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b2e77cbc752d1d3b502426d3d5189099fcac9306 --- /dev/null +++ b/274/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "274", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.5 +} \ No newline at end of file diff --git a/274/surgery_description.txt b/274/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2aad0773c602c7f43b274ee4662f7d8dc60dc1d5 --- /dev/null +++ b/274/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Tumor excision diff --git a/274/surgery_report.txt b/274/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ca6e1e1c62f8af34f8f5c2938e0a205a184db72 --- /dev/null +++ b/274/surgery_report.txt @@ -0,0 +1 @@ +First, the patient is brought into the operating room, identified and the team time-out is carried out in the usual manner. Then induction of anesthesia by the anesthesia colleagues. Then tracheoscopy by the surgeon. In the area of the endolarynx, vocal fold level, subglottic to the trachea and carina, mucosal conditions are unremarkable on all sides. Subsequent intubation of the patient by the anesthesia colleagues. Head reclination by the surgeon and insertion of the flexible esophagogastroscope. Careful endoscopy into the stomach. Mucosal conditions in the stomach and esophagus are normal on all sides. Then insertion with the size C small bore tube. Careful endoscopy into the oropharynx. In the area of the soft and hard palate as well as the tonsil region, the mucosa is normal on all sides. The mucosa is also normal at the base of the tongue, epiglottis and vallecula. The piriform sinus is freely unfoldable and inconspicuous on both sides, as are the postcricoid region and the endolarynx. Subsequent insertion of a Jennings blocker. Tongue suture and disluxation of the tongue for closer inspection of the tongue edge and the underside of the tongue. A large, histologically confirmed carcinoma measuring approx. 1 x 1 cm was found in the area of the underside of the tongue on the right. Demonstration of the findings on and successive excision with half a centimeter safety distance to the macroscopically visible tumor border using a monopolar needle. In the area of the epithelium in depth, carefully dissect further with plastic forceps and scissors and cut out the tumor while maintaining the safety distance. The tumor is thread-marked for frozen section examination. Careful hemostasis using bipolar forceps in the area of the tongue muscles; no macroscopic evidence of further tumor invasion in the wound area. Following notification of an R0 situation by the pathology colleagues and after consultation with , the decision was made to perform a further resection in the area of the cranial wound base towards the tip of the tongue, as there is a close R0 situation here at 12 o'clock. An arcuate, final margin trial is also performed in the area from 9 to 3 o'clock. The post-resection and marginal sample are both thread-marked for final histology; please note this. Conclusion: Overall unremarkable panendoscopy and resection of the histologically confirmed carcinoma on the underside of the tongue without complications. According to the frozen section, there is an R0 resection on all sides; however, please note the resection and the final margin sample and present the patient to the tumor conference, if necessary, order an ultrasound for regional neck status documentation. \ No newline at end of file diff --git a/275/InvasionFront_CD3_block14_x3_y12_patient275_0.json b/275/InvasionFront_CD3_block14_x3_y12_patient275_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5d500b805b7cf89518c6c905b72b997d61ff720f --- /dev/null +++ b/275/InvasionFront_CD3_block14_x3_y12_patient275_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 33832.1, + "Num Detections": 18678, + "Num Negative": 17815, + "Num Positive": 863, + "Positive %": 4.62, + "Num Positive per mm^2": 402.39 + } +} \ No newline at end of file diff --git a/275/InvasionFront_CD3_block14_x4_y12_patient275_1.json b/275/InvasionFront_CD3_block14_x4_y12_patient275_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f03ce04faa5eb95186a2d3b32f7597855d723b21 --- /dev/null +++ b/275/InvasionFront_CD3_block14_x4_y12_patient275_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 34131.9, + "Num Detections": 3669, + "Num Negative": 3664, + "Num Positive": 5, + "Positive %": 0.1363, + "Num Positive per mm^2": 9.293 + } +} \ No newline at end of file diff --git a/275/InvasionFront_CD8_block14_x3_y12_patient275_0.json b/275/InvasionFront_CD8_block14_x3_y12_patient275_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ce1521ac31aeaa22ae0532d379bc1f04a32d7593 --- /dev/null +++ b/275/InvasionFront_CD8_block14_x3_y12_patient275_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11718.8, + "Centroid Y µm": 29209.5, + "Num Detections": 19995, + "Num Negative": 19610, + "Num Positive": 385, + "Positive %": 1.925, + "Num Positive per mm^2": 182.41 + } +} \ No newline at end of file diff --git a/275/InvasionFront_CD8_block14_x4_y12_patient275_1.json b/275/InvasionFront_CD8_block14_x4_y12_patient275_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cc1e20873522ecf49346259697e70a4ca3e6a45e --- /dev/null +++ b/275/InvasionFront_CD8_block14_x4_y12_patient275_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14214.2, + "Centroid Y µm": 29384.4, + "Num Detections": 5348, + "Num Negative": 5307, + "Num Positive": 41, + "Positive %": 0.7666, + "Num Positive per mm^2": 58.89 + } +} \ No newline at end of file diff --git a/275/TumorCenter_CD8_block14_x3_y12_patient275_0.json b/275/TumorCenter_CD8_block14_x3_y12_patient275_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f7a0b4d700eac199c932efbdd3f1ef8224f45166 --- /dev/null +++ b/275/TumorCenter_CD8_block14_x3_y12_patient275_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10519.4, + "Centroid Y µm": 30358.9, + "Num Detections": 9119, + "Num Negative": 8949, + "Num Positive": 170, + "Positive %": 1.864, + "Num Positive per mm^2": 110.69 + } +} \ No newline at end of file diff --git a/275/TumorCenter_CD8_block14_x4_y12_patient275_1.json b/275/TumorCenter_CD8_block14_x4_y12_patient275_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f320af7f3b927348ab111216bb8d42f5c5ff2142 --- /dev/null +++ b/275/TumorCenter_CD8_block14_x4_y12_patient275_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12993.1, + "Centroid Y µm": 30383.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/275/history_text.txt b/275/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c875d52ec252d247a8fa5f1fd941c54d6d730ce8 --- /dev/null +++ b/275/history_text.txt @@ -0,0 +1 @@ +For 5 weeks she has noticed a mass on the right edge of her tongue, weight loss of 6-7 kg within 6 weeks. The tumor on the right side of the tongue cannot be visualized on computed tomography, but there is a suspicious CT scan of the posterior left edge of the tongue. Additional unclear change in the head of the pancreas, clarification recommended. \ No newline at end of file diff --git a/275/icd_codes.txt b/275/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cf422e8d9567fdb2464b75d4b6093c8a641ac4db --- /dev/null +++ b/275/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 R] \ No newline at end of file diff --git a/275/ops_codes.txt b/275/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8594e64ec605a613fc092bed45c7945613df52b1 --- /dev/null +++ b/275/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Tracheobronchoskopie[1-620.x ] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/275/patient_clinical_data.json b/275/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..65026a428f7262d200e9ad19adc60f69cba21775 --- /dev/null +++ b/275/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/275/patient_pathological_data.json b/275/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f79b6eb299e9116a545193aba33db26c9de18760 --- /dev/null +++ b/275/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "275", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.5 +} \ No newline at end of file diff --git a/275/surgery_description.txt b/275/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..676707dd6db7653e4cbb53f6f786a5dfc1fa0969 --- /dev/null +++ b/275/surgery_description.txt @@ -0,0 +1 @@ +Tumor excision and Panendoscopy diff --git a/275/surgery_report.txt b/275/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5041fa53258adc618f544dd92ff9bc8fdfd3968a --- /dev/null +++ b/275/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues, intubation without any problems by the surgeon after an unremarkable tracheoscopy. Start of esophagogastroscopy. Inconspicuous findings on all sides. Positioning of the patient. Insertion of Kleinsasser tube. Endoscopy of the hypopharynx, oropharynx and larynx, inconspicuous findings on all sides. Palpation of the tongue: here induration on both sides of the posterior edge of the tongue with transition to the base of the tongue. Adjustment after tonguing the tongue and insertion of a Jennings lock. An exophytic tumor measuring approx. 1.5 cm is visible. Marking of the excision borders with the monopolar needle. Then complete removal of the tumor with a safety margin of approx. 0.5 - 1 cm on all sides. Frozen section: tumor-free (specimen is inserted in toto). Subsequent inspection of the left side of the tongue. A small exophytic part of approx. 0.5 cm in size is visible here, but the main part of the tumor is submucosal, correlating with the CT. RS with : due to the large wound area on the right, only sampling on the left, no excision. After wedge-shaped, deep PE, a small mucosal suture is made here. Subsequent primary suture of the right posterior border of the tongue through and completion of the operation. Conclusion: Two simultaneous tongue margin carcinomas on the left and right sides, right-sided excision in a frozen section in sano. Further procedure after receipt of the histology of the left tongue margin in our tumor conference. Please CT abdomen for pancreatic CA. \ No newline at end of file diff --git a/276/InvasionFront_CD3_block2_x1_y11_patient276_0.json b/276/InvasionFront_CD3_block2_x1_y11_patient276_0.json new file mode 100644 index 0000000000000000000000000000000000000000..105154e8e18172e3f7a1966bcea95e495b84cad0 --- /dev/null +++ b/276/InvasionFront_CD3_block2_x1_y11_patient276_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 40778.4, + "Num Detections": 19473, + "Num Negative": 18684, + "Num Positive": 789, + "Positive %": 4.052, + "Num Positive per mm^2": 307.69 + } +} \ No newline at end of file diff --git a/276/InvasionFront_CD3_block2_x2_y11_patient276_1.json b/276/InvasionFront_CD3_block2_x2_y11_patient276_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2cf5d316e698205c216d6f26790e2b4d25dd34a2 --- /dev/null +++ b/276/InvasionFront_CD3_block2_x2_y11_patient276_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8545.5, + "Centroid Y µm": 40828.4, + "Num Detections": 21012, + "Num Negative": 20036, + "Num Positive": 976, + "Positive %": 4.645, + "Num Positive per mm^2": 368.26 + } +} \ No newline at end of file diff --git a/276/InvasionFront_CD8_block2_x1_y11_patient276_0.json b/276/InvasionFront_CD8_block2_x1_y11_patient276_0.json new file mode 100644 index 0000000000000000000000000000000000000000..608a9baa6e708fe5ccb284e46a280bf3d1fcdb70 --- /dev/null +++ b/276/InvasionFront_CD8_block2_x1_y11_patient276_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5011.1, + "Centroid Y µm": 28219.1, + "Num Detections": 11712, + "Num Negative": 11522, + "Num Positive": 190, + "Positive %": 1.622, + "Num Positive per mm^2": 105.28 + } +} \ No newline at end of file diff --git a/276/InvasionFront_CD8_block2_x2_y11_patient276_1.json b/276/InvasionFront_CD8_block2_x2_y11_patient276_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9641a8b9a02d5c49a0f7da8f2b10769c97f9c62 --- /dev/null +++ b/276/InvasionFront_CD8_block2_x2_y11_patient276_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7343.8, + "Centroid Y µm": 28328.1, + "Num Detections": 14062, + "Num Negative": 13818, + "Num Positive": 244, + "Positive %": 1.735, + "Num Positive per mm^2": 116.23 + } +} \ No newline at end of file diff --git a/276/TumorCenter_CD3_block2_x1_y11_patient276_0.json b/276/TumorCenter_CD3_block2_x1_y11_patient276_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4bae3c52ac6dda9c4e6296fda3b20b351b6144b8 --- /dev/null +++ b/276/TumorCenter_CD3_block2_x1_y11_patient276_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3448.2, + "Centroid Y µm": 26710.9, + "Num Detections": 16094, + "Num Negative": 14749, + "Num Positive": 1345, + "Positive %": 8.357, + "Num Positive per mm^2": 614.22 + } +} \ No newline at end of file diff --git a/276/TumorCenter_CD3_block2_x2_y11_patient276_1.json b/276/TumorCenter_CD3_block2_x2_y11_patient276_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2ed801d02bfd3f670c426eb07d6b6b23f67da400 --- /dev/null +++ b/276/TumorCenter_CD3_block2_x2_y11_patient276_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 26885.8, + "Num Detections": 15940, + "Num Negative": 14914, + "Num Positive": 1026, + "Positive %": 6.437, + "Num Positive per mm^2": 487.51 + } +} \ No newline at end of file diff --git a/276/TumorCenter_CD8_block2_x1_y11_patient276_0.json b/276/TumorCenter_CD8_block2_x1_y11_patient276_0.json new file mode 100644 index 0000000000000000000000000000000000000000..587659a78043e5f0df85c084c48e6a8f28152f35 --- /dev/null +++ b/276/TumorCenter_CD8_block2_x1_y11_patient276_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 27235.6, + "Num Detections": 10748, + "Num Negative": 10581, + "Num Positive": 167, + "Positive %": 1.554, + "Num Positive per mm^2": 109.01 + } +} \ No newline at end of file diff --git a/276/TumorCenter_CD8_block2_x2_y11_patient276_1.json b/276/TumorCenter_CD8_block2_x2_y11_patient276_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c8cd2f1366cbbf4c87db946e4142c2f44be9c79f --- /dev/null +++ b/276/TumorCenter_CD8_block2_x2_y11_patient276_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8695.4, + "Centroid Y µm": 27185.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/276/history_text.txt b/276/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/276/icd_codes.txt b/276/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/276/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/276/ops_codes.txt b/276/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2e1a61e1bbd87e348105573884b479f49da42626 --- /dev/null +++ b/276/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Spaltung des weichen und/oder harten Gaumens sonstige[5-295.2x ] Partielle Glossektomie durch Pharyngotomie sonstige[5-251.2x ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Entnahme Spalthaut zur Transplantation Unterarm[5-901.08 R] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/276/patient_clinical_data.json b/276/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..62d6ea368d9aea2250d7d867cb509d64bbd2a76a --- /dev/null +++ b/276/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/276/patient_pathological_data.json b/276/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..333dfba904eeeaac57d04a5f9417ba4ace7ab86a --- /dev/null +++ b/276/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "276", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/276/surgery_description.txt b/276/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0100e2969a8ab2e5535966314dbcf2e8dd6a6858 --- /dev/null +++ b/276/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Left neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/276/surgery_report.txt b/276/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2b56da14b2a15e8060c9bbfa0f04478d1335dd97 --- /dev/null +++ b/276/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by anesthesia colleagues, intubation by anesthesia colleagues. Sterile washing and draping. Insertion of a McIvor oral spatula and inspection of the tumor region. The tumor moves from the tonsil lobe to the soft palate, from there to the base of the uvula, to the anterior and posterior palatal arch, then to the posterior pharyngeal wall caudally to the right-sided vallecula and the lateral pharyngeal wall. Start with transoral tumor resection in the area of the soft palate. Successive resection of the tumor with a safety margin of 1 cm. Dissection down to the base of the tongue. The tumor also infiltrates the base of the tongue. Then change to the transcervical region. Skin incision in the area of the anterior border of the sternocleidomastoid. Exposure of the lower part of the sternocleidomastoid muscle. Exposure of the internal jugular vein in the lower part. Exposure of the omohyoid muscle. Then transection of the sternocleidomastoid muscle, because the N3 neck metastasis infiltrates the upper part of the muscle and also the vein. Then removal of the internal jugular vein. Dissection of the tumor from the internal carotid artery. The external carotid artery must also be removed due to tumor infiltration. In addition, superficial plexus branches and the accessorius nerve must also be removed, as well as the hypoglossal nerve and the submandibular gland. Level I also contains large, conspicuous nodes. Level I is therefore also removed. The tendon of the omohyoid muscle, which is also infiltrated, is severed. The caudal part of the parotid gland is also infiltrated and the oral branch must also be resected. The tumor is in direct contact with the N3 neck metastasis, but is not completely connected to it, so it is possible to remove the metastasis separately from the tumor and also the remaining neck tissue. The tumor is then pulled outwards from the transcervical area and resected. The result is a fairly large, three-dimensional defect from the vallecula up to the soft palate. The defect is then measured and the graft designed. The graft is designed so that it is 17 cm long and has an angled section for tongue reconstruction, which is also approx. 8 to 9 cm in size. This graft is then lifted by on the arm. Mark the graft for this purpose. Skin incision. Visualization of the vascular situation in the crook of the elbow and the vascular pedicle. Exposure of the superficial ramus of the radial nerve, which is divided into 2 branches. One branch is severed by due to the size of the graft. However, the main branch remains intact. Now change the operators from to and complete the graft elevation. To do this, lift the graft from the tendon bed. Exposure of the brachioradialis muscle and preparation of the pedicle in the usual manner. Then further dissection of the vascular situation in the crook of the elbow and removal of the graft while preserving 3 venous vessels. Marking of the radial artery. Now conditioning of the vessels in the neck area. The stump of the internal jugular vein is already thrombosed, as is the stump of the external jugular vein. This is no longer an option for the transplant. An accompanying vein in the area of the omohyoid is prepared. The stump of the external artery is also already occluded and is no longer suitable as a connecting vessel. The superior thyroid artery is therefore prepared and conditioned. Now fitting the graft into the defect and suturing the graft, mostly transcervically. This is extremely difficult because the graft is very large and very bulky and also because of the considerable swelling in the palate, uvula and tongue. In the end, the graft was able to fit completely. Now the vessels are anastomosed, first the arterial and then the venous vessels. Only one venous vessel can be connected, as the other two do not show any blood return; they are clipped. A flap is then inserted and the wound is closed in two layers. Parallel to the graft elevation, the neck is dissected on the left side, initially through and . Exposure of the sternocleidomastoid muscle. Representation of the omohyoid muscle. Exposure of the cervical vascular sheath. Free preparation of the internal jugular vein. Exposure of the submandibular gland. Exposure of the omohyoid muscle. Clearing of the medial neck block with preservation of the facial vein and artery. Exposure of level IIa with preservation of the accessorius nerve. Then transfer of and removal of neck levels II b to V a while preserving the plexus branches. Insertion of a Redon drainage, two-layer wound closure. Then perform the tracheotomy through and . Make a skin incision below the cricoid cartilage. Dissection down to the musculature. Splitting of the musculature in the linea alba. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus. Exposure of the anterior wall of the trachea. Entering the trachea between the 2nd and 3rd tracheal cartilage. Creation of a visor tracheotomy. Creation of a mucocutaneous anastomosis and reintubation on an 8 mm tube. A flap is inserted in the area of the right side of the neck and a two-layer wound closure is performed. The patient goes to IOI intubated and ventilated due to heart and lung problems. Please perform an X-ray gruel swallow on the 10th postoperative day. Continue antibiotics for at least 24 hours. \ No newline at end of file diff --git a/277/InvasionFront_CD3_block19_x3_y8_patient277_0.json b/277/InvasionFront_CD3_block19_x3_y8_patient277_0.json new file mode 100644 index 0000000000000000000000000000000000000000..82eb76bfd06a6a90669348ae96e850bd1ccae493 --- /dev/null +++ b/277/InvasionFront_CD3_block19_x3_y8_patient277_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11593.9, + "Centroid Y µm": 22088.3, + "Num Detections": 21704, + "Num Negative": 20690, + "Num Positive": 1014, + "Positive %": 4.672, + "Num Positive per mm^2": 406.69 + } +} \ No newline at end of file diff --git a/277/InvasionFront_CD3_block19_x4_y8_patient277_1.json b/277/InvasionFront_CD3_block19_x4_y8_patient277_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2281181079e439f2d1af55dd3d56b282d38ee30 --- /dev/null +++ b/277/InvasionFront_CD3_block19_x4_y8_patient277_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 22488.1, + "Num Detections": 15115, + "Num Negative": 14450, + "Num Positive": 665, + "Positive %": 4.4, + "Num Positive per mm^2": 364.69 + } +} \ No newline at end of file diff --git a/277/InvasionFront_CD8_block19_x3_y8_patient277_0.json b/277/InvasionFront_CD8_block19_x3_y8_patient277_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e846767fb0b64c7422b637aab8fc78745ea48d1 --- /dev/null +++ b/277/InvasionFront_CD8_block19_x3_y8_patient277_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11443.9, + "Centroid Y µm": 29834.2, + "Num Detections": 13946, + "Num Negative": 13558, + "Num Positive": 388, + "Positive %": 2.782, + "Num Positive per mm^2": 240.94 + } +} \ No newline at end of file diff --git a/277/InvasionFront_CD8_block19_x4_y8_patient277_1.json b/277/InvasionFront_CD8_block19_x4_y8_patient277_1.json new file mode 100644 index 0000000000000000000000000000000000000000..27cb201d313e39619d2205c9478c05a3229c6212 --- /dev/null +++ b/277/InvasionFront_CD8_block19_x4_y8_patient277_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14092.5, + "Centroid Y µm": 29934.2, + "Num Detections": 15097, + "Num Negative": 14429, + "Num Positive": 668, + "Positive %": 4.425, + "Num Positive per mm^2": 401.22 + } +} \ No newline at end of file diff --git a/277/TumorCenter_CD3_block19_x3_y8_patient277_0.json b/277/TumorCenter_CD3_block19_x3_y8_patient277_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1dca28ac927538361acade6cc2dfc7b7c889beeb --- /dev/null +++ b/277/TumorCenter_CD3_block19_x3_y8_patient277_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12793.2, + "Centroid Y µm": 21188.8, + "Num Detections": 16199, + "Num Negative": 15302, + "Num Positive": 897, + "Positive %": 5.537, + "Num Positive per mm^2": 488.35 + } +} \ No newline at end of file diff --git a/277/TumorCenter_CD3_block19_x4_y8_patient277_1.json b/277/TumorCenter_CD3_block19_x4_y8_patient277_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b4fb1686db83b9fc15c723294cf675ab9947c355 --- /dev/null +++ b/277/TumorCenter_CD3_block19_x4_y8_patient277_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15216.9, + "Centroid Y µm": 20764.0, + "Num Detections": 16343, + "Num Negative": 15590, + "Num Positive": 753, + "Positive %": 4.607, + "Num Positive per mm^2": 391.54 + } +} \ No newline at end of file diff --git a/277/TumorCenter_CD8_block19_x3_y8_patient277_0.json b/277/TumorCenter_CD8_block19_x3_y8_patient277_0.json new file mode 100644 index 0000000000000000000000000000000000000000..15493f3e6b1675c4e9693e7a0d350aba672ee7d0 --- /dev/null +++ b/277/TumorCenter_CD8_block19_x3_y8_patient277_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 31158.5, + "Num Detections": 15690, + "Num Negative": 14259, + "Num Positive": 1431, + "Positive %": 9.12, + "Num Positive per mm^2": 732.21 + } +} \ No newline at end of file diff --git a/277/TumorCenter_CD8_block19_x4_y8_patient277_1.json b/277/TumorCenter_CD8_block19_x4_y8_patient277_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a6c5d324306c1c89bc605981d21f0ed51d50bd23 --- /dev/null +++ b/277/TumorCenter_CD8_block19_x4_y8_patient277_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 31133.5, + "Num Detections": 18051, + "Num Negative": 16445, + "Num Positive": 1606, + "Positive %": 8.897, + "Num Positive per mm^2": 808.66 + } +} \ No newline at end of file diff --git a/277/history_text.txt b/277/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/277/icd_codes.txt b/277/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8eb6cd7fac5c3b99c69823658dd38a1c2ee7589f --- /dev/null +++ b/277/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 L] \ No newline at end of file diff --git a/277/ops_codes.txt b/277/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d78d0b88347cc974b060923a760970c9fa975e1 --- /dev/null +++ b/277/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Permanente Tracheotomie[5-312.0 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion][5-295.xx ] Inzision Zungengrund[5-250.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Ösophagomyotomie sonstige[5-420.0x ] \ No newline at end of file diff --git a/277/patient_clinical_data.json b/277/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b6a0efba51c55cf8f9d578cdf7e3639771a1bf9a --- /dev/null +++ b/277/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/277/patient_pathological_data.json b/277/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5dd0867b1cac15e840a626e30bc27f82df15679f --- /dev/null +++ b/277/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "277", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 24.0 +} \ No newline at end of file diff --git a/277/surgery_description.txt b/277/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e9a295fa09d8b12313c5b7cf17d5f8780c87b290 --- /dev/null +++ b/277/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection diff --git a/277/surgery_report.txt b/277/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a378c6bdc363816d6c09f205fccd4f4e555bfa04 --- /dev/null +++ b/277/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by anesthesia colleagues. Intubation via the existing tracheostoma by the anesthesia colleagues. Entry with the Kleinsasser tube and inspection of the hypopharynx and larynx. There is an exophytic mass in the supraglottis area, starting at the petiolus of the epiglottis, passing to the aryepiglottic fold, occupying the entire arytenoid cartilage on the left side, pocket fold and vocal fold. The mass extends to the medial and anterior wall of the piriform sinus, partially also to the lateral wall. Enter with the 0° view and inspect the subglottis. No tumor infiltration here. Sterile washing and draping. Creation of an apron flap in the usual manner. Neck dissection on the right (): Skin incision in the sense of an apron flap. From right to left, cutting through the cutaneous subcutaneous tissue and the platysma. Identification of the external jugular vein on the right side. Subplatysmal dissection and creation of the apron flap. Identification of the sternocleidomastoid muscle and dissection of the anterior edge of the muscle in depth. The branches of the cervical plexus are revealed at the lower edge of the muscle. Dissection along the muscle cranially and exposure of the accessorius nerve. Expose the submandibular gland and open the glandular capsule. Raise the upper end of the capsule to securely protect the marginal ramus. Identification of the venter posterior digastric muscle and dissection on the digastric muscle ventrally towards the hyoid bone. Identification of the auricularis magnus nerve on the sternocleidomastoid muscle. Identification of the omohyoid muscle and dissection on the muscle up to the hyoid bone. Dissection on the internal jugular vein. Division of the neck preparation on the internal jugular vein into a lateral and a medial resection. Identification of the hypoglossal nerve. This can be preserved during dissection. First detach the lateral neck preparation from cranial to caudal on the deep cervical fascia. Particular care is taken not to injure the accessorius nerve or the branches of the cervical plexus. Release the medial neck preparation. Care is taken to preserve the arterial and venous vessels. Completion of the neck dissection on the right side without complications. Bipolar coagulation to stop bleeding. Wound irrigation. At the end, the wound is dry. Neck dissection on the left side: A large metastatic conglomerate can be seen on the left side, which partially grows into the sternocleidomastoid muscle. The sternocleidomastoid muscle is visualized and partially resected in the area of level II to IV. Exposure of the submandibular gland. Exposure of the omohyoid and digastric muscles and the accessorius and hypoglossal nerves. A thick tumor conglomerate can be seen, ranging from level II b to level IV. This conglomerate infiltrates the hypoglossal nerve, parts of the cervical plexus, parts of the sternocleidomastoid muscle, the internal jugular vein, the external jugular vein, the external carotid artery with all its branches and also the wall of the piriform sinus and parts of the thyroid cartilage. The internal jugular vein must be separated above and below. The external carotid artery is removed. The metastasis had to be laboriously dissected from the common and internal carotid artery for this purpose. Man sees clear tumor infiltration of the pharyngeal musculature. Demonstration on and . It is decided to resect this part of the pharyngeal wall. Release the larynx by removing the hyoid bone. Detachment of the thyroid gland and release of the piriform sinus on the right side; this is not possible on the left side due to the tumor. Entering the pharynx via the right side. Pull out the epiglottis and cut around the tumor in the pharyngeal region and at the postcricoid region down to the esophageal entrance. Here, the tumor can be removed. Separate the larynx below the cricoid cartilage and take marginal samples. All marginal samples are tumor-free in the frozen section. Consultation with . He recommends avoiding a flapplasty. He recommends releasing the base of the tongue to reduce the tension on the pharyngeal suture. Now release the base of the tongue using . Then insertion of a Provox-Vega prosthesis. Perform a myotomy at the insertions of the sternocleidomastoid muscle and an esophageal myotomy and now perform a three-layer pharyngeal suture with a "T" at the base of the tongue. Insertion of Redon drains and two-layer wound closure. Application of a pressure bandage and completion of the procedure without complications. Post-operative X-ray swallowing on the 14th postoperative day, followed by diet reconstruction. \ No newline at end of file diff --git a/278/InvasionFront_CD3_block8_x1_y6_patient278_0.json b/278/InvasionFront_CD3_block8_x1_y6_patient278_0.json new file mode 100644 index 0000000000000000000000000000000000000000..088cf7c161ee0a08b32201c3ac5fd4b4aaec32b0 --- /dev/null +++ b/278/InvasionFront_CD3_block8_x1_y6_patient278_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 25386.6, + "Num Detections": 20715, + "Num Negative": 19305, + "Num Positive": 1410, + "Positive %": 6.807, + "Num Positive per mm^2": 569.16 + } +} \ No newline at end of file diff --git a/278/InvasionFront_CD3_block8_x2_y6_patient278_1.json b/278/InvasionFront_CD3_block8_x2_y6_patient278_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5bc498b7ec4adf0c2c09d29e003188e5846337d9 --- /dev/null +++ b/278/InvasionFront_CD3_block8_x2_y6_patient278_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 25286.6, + "Num Detections": 24365, + "Num Negative": 24025, + "Num Positive": 340, + "Positive %": 1.395, + "Num Positive per mm^2": 131.21 + } +} \ No newline at end of file diff --git a/278/InvasionFront_CD8_block8_x1_y6_patient278_0.json b/278/InvasionFront_CD8_block8_x1_y6_patient278_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c69ec89c3aaad558e1bfd2f1c1797c857afe58f7 --- /dev/null +++ b/278/InvasionFront_CD8_block8_x1_y6_patient278_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4047.9, + "Centroid Y µm": 14717.2, + "Num Detections": 11864, + "Num Negative": 10548, + "Num Positive": 1316, + "Positive %": 11.09, + "Num Positive per mm^2": 1010.9 + } +} \ No newline at end of file diff --git a/278/InvasionFront_CD8_block8_x2_y6_patient278_1.json b/278/InvasionFront_CD8_block8_x2_y6_patient278_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f27a299641a7914a102f314caadb34710fc6c7c --- /dev/null +++ b/278/InvasionFront_CD8_block8_x2_y6_patient278_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6871.4, + "Centroid Y µm": 14942.1, + "Num Detections": 23690, + "Num Negative": 23400, + "Num Positive": 290, + "Positive %": 1.224, + "Num Positive per mm^2": 112.48 + } +} \ No newline at end of file diff --git a/278/TumorCenter_CD3_block8_x1_y6_patient278_0.json b/278/TumorCenter_CD3_block8_x1_y6_patient278_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f6d18577aad2d6745438f3561fa091ec1fcb135 --- /dev/null +++ b/278/TumorCenter_CD3_block8_x1_y6_patient278_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4612.0, + "Centroid Y µm": 16751.6, + "Num Detections": 14518, + "Num Negative": 13598, + "Num Positive": 920, + "Positive %": 6.337, + "Num Positive per mm^2": 583.82 + } +} \ No newline at end of file diff --git a/278/TumorCenter_CD3_block8_x2_y6_patient278_1.json b/278/TumorCenter_CD3_block8_x2_y6_patient278_1.json new file mode 100644 index 0000000000000000000000000000000000000000..167bfc3d23b522f4a67fce4fc0941e5e2ce66c98 --- /dev/null +++ b/278/TumorCenter_CD3_block8_x2_y6_patient278_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7121.2, + "Centroid Y µm": 16491.3, + "Num Detections": 15846, + "Num Negative": 13666, + "Num Positive": 2180, + "Positive %": 13.76, + "Num Positive per mm^2": 1174.7 + } +} \ No newline at end of file diff --git a/278/TumorCenter_CD8_block8_x1_y6_patient278_0.json b/278/TumorCenter_CD8_block8_x1_y6_patient278_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f667decb5812ed0644777648435540b8bd14c564 --- /dev/null +++ b/278/TumorCenter_CD8_block8_x1_y6_patient278_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 16091.5, + "Num Detections": 20377, + "Num Negative": 20261, + "Num Positive": 116, + "Positive %": 0.5693, + "Num Positive per mm^2": 50.22 + } +} \ No newline at end of file diff --git a/278/TumorCenter_CD8_block8_x2_y6_patient278_1.json b/278/TumorCenter_CD8_block8_x2_y6_patient278_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bfa69f5896569a817de67c4190c2d460fa1383d6 --- /dev/null +++ b/278/TumorCenter_CD8_block8_x2_y6_patient278_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6646.5, + "Centroid Y µm": 15941.6, + "Num Detections": 16307, + "Num Negative": 15894, + "Num Positive": 413, + "Positive %": 2.533, + "Num Positive per mm^2": 227.94 + } +} \ No newline at end of file diff --git a/278/history_text.txt b/278/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0de1dfbd8897c3af3845973bb0f1d2119c08c833 --- /dev/null +++ b/278/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed oropharyngeal carcinoma on the left. The above-mentioned intervention is therefore indicated for treatment. \ No newline at end of file diff --git a/278/icd_codes.txt b/278/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..09e400318cc43a2b83726cbbb062a7b905c661db --- /dev/null +++ b/278/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] Halslymphknotenmetastasen[C77.0 ] \ No newline at end of file diff --git a/278/ops_codes.txt b/278/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..be700202a62111f4bd92a152f6b2b10d17a606ab --- /dev/null +++ b/278/ops_codes.txt @@ -0,0 +1 @@ +Radikale Resektion des Pharynx durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Vollhaut Entnahmestelle Leisten- und Genitalregion[5-901.1c R] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] \ No newline at end of file diff --git a/278/patient_clinical_data.json b/278/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d523bc79ba4fd254d8368a45aaf91c0ccb51b360 --- /dev/null +++ b/278/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/278/patient_pathological_data.json b/278/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..184f1983e06f9f8850c0891b4ceab6831e06f265 --- /dev/null +++ b/278/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "278", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 6.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/278/surgery_description.txt b/278/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..45174b43dd0f8f015e9590faf39d77392ddce481 --- /dev/null +++ b/278/surgery_description.txt @@ -0,0 +1 @@ +Transcervical resection, Pharyngoscopy, MLE (Microlaryngoscopy and Endoscopy), Neck dissection, Free flap (Radial) diff --git a/278/surgery_report.txt b/278/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5cef7f898e602337175975978dd433c256af5968 --- /dev/null +++ b/278/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and MLE again: The exophytic tumor is visible, which starts at the palatal arch next to the uvula on the left, extends over the tonsillar lobe to the base of the tongue. In the area of the pharyngeal side wall up to the edge of the posterior wall. The tumor shows exulcerative character and deep growth. Therefore primary indication for combined resection. Sterile draping and injection of a total of 20 ml Ultracaine 1% with adrenaline in the area of both sides of the neck. Start with transoral resection: Cut around the tumor with a safety margin of 1 ˝ to 2 cm on all sides, initially from the enoral side. Smaller parts of the palatal arch on the right, the uvula, the entire palatal arch on the left, mucosa along the alveolar ridge up to the glossoalveolar groove and the beginning of the tongue base, pharyngeal posterior wall falls to the middle, caudally the resection extends from the transoral side to the entrance of the piriform sinus. Then repositioning for neck dissection on the right with subsequent completion of the resection from transcervical: submandibular incision. Cut along the sternocleidomastoid muscle caudally. Exposure of the sternocleidomastoid muscle. Showing digastric muscle, submandibular gland. Showing the omohyoid muscle. Exposure of the cervical vascular sheath, internal jugular vein, external and internal carotid artery. Exposure of the hypoglossal nerve, vagus nerve and accessorius nerve. Successive evacuation level I b to V. Co-resection of the submandibular gland. Exposure and preservation of the superior thyroid artery. The facial artery is ligated cranially in preparation for tumor resection. The transoral resection is then completed by transcervical resection: the entire pharyngeal wall is included up to the cervical vascular sheath. A portion of the base of the tongue is resected caudally as well as the mucosa up to the piriform sinus entrance and all soft tissue up to the cornu superius or hyoid bone. In total, marginal samples are taken from the palatal arch, laterally to the alveolar ridge, from the area of the posterior pharyngeal wall. In addition, a cranial basal margin sample and a caudal basal margin sample are taken. All marginal samples are sent to frozen section diagnostics with the tumor specimen, which is marked with a thread. In the frozen section, all margin samples are tumor-free, as is the specimen. Thus R0 situation intraoperatively. Subsequent left neck dissection and tracheotomy (). Neck dissection left: Skin incision. Then exposure of the anterior edge of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and digastric muscle. Visualization of the cervical vascular sheath. Level II shows several lymph node metastases, which are removed while sparing the vessels of the jugular vein, the external and internal carotid arteries and while sparing and exposing the hypoglossal nerve, vagus nerve and accessorius nerve. Then further successive evacuation of levels I, III and V. Exposure and preservation of the superior thyroid artery and facial artery. Then repositioning for tracheotomy. Skin incision in the usual manner. Dissection of the musculature. Push the muscles to the side and expose the thyroid gland. Undermining of the thyroid gland and clamping on both sides. Then transection of the isthmus and ligation on both sides. Exposure of the trachea. Opening of the trachea between the 2nd and 3rd tracheal cartilage gap. Omission of a Björk flap and epithelialization of the skin. Insertion of a laryngectomy tube, which was later intubated with a tracheal cannula. The radial flap is then removed: first the size and dimensions of the flap are measured at the situs. Maximum length 14 cm, maximum width 9 cm. The size and dimensions of the flap are marked on the forearm. Flap elevation is performed without tourniquet. Saturation at the beginning 100%. Cut around the flap first from the ulnar, then from the radial side. Extension of the incision curved in the direction of the crook of the elbow. Subfascial elevation of the flap successively. Exposure of the flap pedicle below the brachioradialis. Previously, the superficial venous outflow was also exposed above it. The radial artery was visualized and clamped for 20 minutes. There was no deterioration in saturation, which was always 100%. Subsequently, the radial artery was removed and treated with 4-0 Prolene stitches caudally and cranially. Flap is successively lifted subfascially, smaller vessels are coagulated bipolarly or supplied with clips. Lifting of the flap pedicle up to the elbow. Exposure of the radial artery, brachial artery, ulnar artery and interosseous artery. Also show the radial vein and the superficial venous outflow, which ends in 2 branches in the area of the cephalic vein. There is a stable connection to the deep venous system. Subsequent removal of the flap, ligation of the veins, removal of the radial artery before the interosseous outlet. Here clip and stitch sutures with 4-0 Prolene. Flap is irrigated with heparin. Subsequent insertion of the flap into the defect: The flap is inserted into the defect according to the size and shape lifted. The flap pedicle is inserted caudally below the preserved hypoglossal nerve on the left and passed through a previously created tunnel to the right side. Successive suturing of the flap, partly with sutures in the defect. Tension-free, anatomically correct suturing is achieved. Subsequent anastomosis of the vessels on the right side: conditioning of the radial artery and the superior thyroid artery. These are sutured using 8-0 Ethilon single-button sutures. After opening the clamps, good arterial flow and very good venous return. Subsequent conditioning of the radial vein and cephalic vein. Also conditioning of a small outlet from the facial vein and the external jugular vein. The smaller radial vein is anastomosed to the outlet from the facial vein using a 1.5 mm coupler. The cephalic vein is also anastomosed with the external jugular vein using a second coupler size 3.5 mm. Good venous return in each case. Positive smear phenomenon. Flap very well perfused intraoperatively. Subsequent irrigation of the wound area, careful hemostasis. Layered wound closure with insertion of a Redon drain in each case. The position of the anastomosis in the area of the external jugular vein is marked. Then insertion of an 8 mm tracheal cannula, which is fixed with sutures. Defect coverage of the forearm using inguinal skin from the right: An appropriately sized piece of full-thickness skin is removed from the groin area in the typical manner. The inguinal skin is mobilized accordingly and then closed in several layers with the insertion of a Redon drain. Skin sutures using the Donati technique. Full-thickness skin is then thinned out and successively sutured into the defect on the caudal forearm. This is done without tension. The upper sections of the wound on the forearm are closed in layers in the typical manner. A hydrogel-Mepilex dressing is then applied, followed by a loose compress dressing and wrapping in absorbent cotton. Fitting of a Kramer splint and wrapping in an elastic bandage. The procedure is completed without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue antibiotics, which were started preoperatively, for a total of 1 week. Heparin perfusor 500 units per hour for 5 days. Flap control in typical clinical manner and by means of Doppler control for 5 days. Total cT3 cN2c oropharyngeal carcinoma on the left. R0 resection intraoperatively. Postoperatively, due to the overall situation, RCT to be discussed. Feeding via a PEG tube for 10 days, then control of swallowing of gruel and diet build-up. \ No newline at end of file diff --git a/279/InvasionFront_CD3_block2_x1_y6_patient279_0.json b/279/InvasionFront_CD3_block2_x1_y6_patient279_0.json new file mode 100644 index 0000000000000000000000000000000000000000..10c885ecf9179870c356835dd6f15c808e96ad10 --- /dev/null +++ b/279/InvasionFront_CD3_block2_x1_y6_patient279_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 28235.1, + "Num Detections": 21751, + "Num Negative": 21129, + "Num Positive": 622, + "Positive %": 2.86, + "Num Positive per mm^2": 247.57 + } +} \ No newline at end of file diff --git a/279/InvasionFront_CD3_block2_x2_y6_patient279_1.json b/279/InvasionFront_CD3_block2_x2_y6_patient279_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a9f1e2595dc2df9f98ca87b1182e68641591ec5 --- /dev/null +++ b/279/InvasionFront_CD3_block2_x2_y6_patient279_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8995.2, + "Centroid Y µm": 28310.0, + "Num Detections": 20786, + "Num Negative": 18939, + "Num Positive": 1847, + "Positive %": 8.886, + "Num Positive per mm^2": 758.78 + } +} \ No newline at end of file diff --git a/279/InvasionFront_CD8_block2_x1_y6_patient279_0.json b/279/InvasionFront_CD8_block2_x1_y6_patient279_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eed200e9c70e329e28f0ec5d34f5816e0e318b40 --- /dev/null +++ b/279/InvasionFront_CD8_block2_x1_y6_patient279_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5147.3, + "Centroid Y µm": 15866.6, + "Num Detections": 19743, + "Num Negative": 19260, + "Num Positive": 483, + "Positive %": 2.446, + "Num Positive per mm^2": 202.21 + } +} \ No newline at end of file diff --git a/279/InvasionFront_CD8_block2_x2_y6_patient279_1.json b/279/InvasionFront_CD8_block2_x2_y6_patient279_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f04366d508f79e7978f221bc3a9cdba722ee0ff8 --- /dev/null +++ b/279/InvasionFront_CD8_block2_x2_y6_patient279_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7845.8, + "Centroid Y µm": 16016.5, + "Num Detections": 20354, + "Num Negative": 19734, + "Num Positive": 620, + "Positive %": 3.046, + "Num Positive per mm^2": 267.67 + } +} \ No newline at end of file diff --git a/279/TumorCenter_CD3_block2_x1_y6_patient279_0.json b/279/TumorCenter_CD3_block2_x1_y6_patient279_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b4d160260f6cb1fd4caddd5b22833f269dee7b57 --- /dev/null +++ b/279/TumorCenter_CD3_block2_x1_y6_patient279_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 14267.4, + "Num Detections": 23409, + "Num Negative": 21474, + "Num Positive": 1935, + "Positive %": 8.266, + "Num Positive per mm^2": 806.6 + } +} \ No newline at end of file diff --git a/279/TumorCenter_CD3_block2_x2_y6_patient279_1.json b/279/TumorCenter_CD3_block2_x2_y6_patient279_1.json new file mode 100644 index 0000000000000000000000000000000000000000..43608ccb1b9736643a6c8e1fffb37c3012d347c6 --- /dev/null +++ b/279/TumorCenter_CD3_block2_x2_y6_patient279_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6696.5, + "Centroid Y µm": 14367.4, + "Num Detections": 21108, + "Num Negative": 18870, + "Num Positive": 2238, + "Positive %": 10.6, + "Num Positive per mm^2": 951.41 + } +} \ No newline at end of file diff --git a/279/TumorCenter_CD8_block2_x1_y6_patient279_0.json b/279/TumorCenter_CD8_block2_x1_y6_patient279_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0d123e46749bfd92f617e658df60198ab74857e1 --- /dev/null +++ b/279/TumorCenter_CD8_block2_x1_y6_patient279_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5747.0, + "Centroid Y µm": 14792.2, + "Num Detections": 24899, + "Num Negative": 24404, + "Num Positive": 495, + "Positive %": 1.988, + "Num Positive per mm^2": 203.69 + } +} \ No newline at end of file diff --git a/279/TumorCenter_CD8_block2_x2_y6_patient279_1.json b/279/TumorCenter_CD8_block2_x2_y6_patient279_1.json new file mode 100644 index 0000000000000000000000000000000000000000..db404cab40d6b71f2d6930aa568d3ebdddc53345 --- /dev/null +++ b/279/TumorCenter_CD8_block2_x2_y6_patient279_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8370.6, + "Centroid Y µm": 14717.2, + "Num Detections": 24356, + "Num Negative": 23723, + "Num Positive": 633, + "Positive %": 2.599, + "Num Positive per mm^2": 263.33 + } +} \ No newline at end of file diff --git a/279/history_text.txt b/279/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9767e801f97e7bdaf22072ca297301396286d80e --- /dev/null +++ b/279/history_text.txt @@ -0,0 +1 @@ +In the patient, a squamous cell carcinoma in the area of the left soft palate on the anterior surface was confirmed externally by histology. Sonography shows a roundish nodus on the left in level II, but only 5 mm, therefore cN1 neck status is possible in principle. The primary tumor cannot be delineated on computed tomography; there are unspecific, most likely reactive, enlarged lymph nodes on both sides, no evidence of lung metastases. There is therefore now an indication for the above-mentioned operation. \ No newline at end of file diff --git a/279/icd_codes.txt b/279/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7fd9523b2a03083926554fc9ea5c85857ef0160a --- /dev/null +++ b/279/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Weicher Gaumen[C05.1 ] \ No newline at end of file diff --git a/279/ops_codes.txt b/279/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..53ea513d8057001576c9f04865ec3023131abaef --- /dev/null +++ b/279/ops_codes.txt @@ -0,0 +1 @@ +Selektive Neck dissection in 4 Regionen[5-403.03 L] Gaumentumorexzision[5-272.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] \ No newline at end of file diff --git a/279/patient_clinical_data.json b/279/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1beaf2a34ebd078c8ba95cedaef2ecc8a99c6f20 --- /dev/null +++ b/279/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 49, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 8, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/279/patient_pathological_data.json b/279/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0e642f0f4f4bea4ace4ec0ba8ec27bd935778282 --- /dev/null +++ b/279/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "279", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/279/surgery_description.txt b/279/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f1b3646d8f9e116a66e0ae42fe9ea76ca8bc8fe --- /dev/null +++ b/279/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy diff --git a/279/surgery_report.txt b/279/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4544a831351b87d942ee5f93032dd9066377b73c --- /dev/null +++ b/279/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia by the anesthesia colleagues. Then tracheoscopy and intubation by . This reveals an inconspicuous mucosa up to the caudal carina. Subsequent inspection and palpation of the tongue, base of tongue, tonsil lobe and soft palate. A slight induration is palpated on the front of the soft palate on the left side, just above the upper alveolar ridge, measuring just under 1 cm2 on inspection. The tongue, base of the tongue and floor of the mouth are inconspicuous on palpation. Now insert the size C Kleinsasser tube. Mirror forward into the piriform sinus, which can be freely unfolded on both sides. The postcricoid region, interaryngeal region and endolarynx are inconspicuous. The esophagogastroscopy was then performed. This is completely unremarkable. Now proceed to tumor excision. Insert the Mc Ivor oral spatula for this. Marking of the subsequent resectate borders using a monopolar and subsequent monopolar incision around the tumor. Subsequent cold dissection in depth and removal of the tumor, which appears to be growing on the surface. Marking at 12 o'clock short short and at 9 o'clock median short long and sending for frozen section. Subtle hemostasis and positioning of the patient for neck dissection. Injection of 10 ml xylocaine with adrenaline in the area of the subsequent skin incision. Then abjode and sterile draping of the surgical field. Now start with the skin incision on the mastoid, curving forward to caudal to supraclavicular. Dissection of the subcutaneous tissue and the platysma. Exposure of the auricularis magnus nerve and the external jugular vein. Ligation of the external jugular vein and protection of the auricular nerve. Subsequent exposure of the platysma and separate dissection. Exposure of the anterior margin of the sternocleidomastoid muscle from caudal to cranial. Subsequently, cranial preparation on the capsule of the submandibular gland and removal or tapping caudally of the capsule in the anterior neck preparation. Dissection on the digaster venter posteriorly and dissection anteriorly. Then caudal dissection of the omohyoid muscle with dissection anteriorly and union with the anterior neck preparation cranially. Subsequent dissection of the lateral neck preparation. Free preparation of the vein with removal of the outer leaf and tapping into the neck preparation. Develop the neck preparation from caudal to cranial. In doing so, protect the cervical plexus. The common carotid artery is dissected in depth and the vagus nerve is exposed. Further dissection in a cranial direction. Exposure and protection of the accessorius nerve. Dissection of level IIb. Detachment of the lateral neck preparation in toto. Subsequent detachment of the previously dissected anterior neck preparation. Subtle hemostasis, followed by insertion of a Redon drain, subcutaneous and platysma suture with 5-0 Ethilon. Subsequent transition to enoral resection after the frozen section revealed that the squamous cell carcinoma was resected at 9 o'clock with less than 1 mm in sano, but the carcinoma in situ was margin-forming at the same site. Therefore, resection from 12 o'clock median to after 6 o'clock on a width of approx. 0.5 cm and removal of a margin sample. Both are sent for final histology. Subtle hemostasis and termination of the operation at this point without complications. Conclusion: Squamous cell carcinoma cT1 oral cavity soft palate anterior left side removed in sano in a frozen section. However, here carcinoma in situ forming a margin, a resection and a margin sample were removed, these were sent for final histology. Neck dissection level II-V left side performed without complications. \ No newline at end of file diff --git a/280/InvasionFront_CD3_block18_x3_y11_patient280_0.json b/280/InvasionFront_CD3_block18_x3_y11_patient280_0.json new file mode 100644 index 0000000000000000000000000000000000000000..97ade035dec6f0e8f60efb4beaa3616b2e280e8d --- /dev/null +++ b/280/InvasionFront_CD3_block18_x3_y11_patient280_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10694.3, + "Centroid Y µm": 32407.8, + "Num Detections": 12236, + "Num Negative": 8905, + "Num Positive": 3331, + "Positive %": 27.22, + "Num Positive per mm^2": 2621.2 + } +} \ No newline at end of file diff --git a/280/InvasionFront_CD3_block18_x4_y11_patient280_1.json b/280/InvasionFront_CD3_block18_x4_y11_patient280_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d8d3f6dbc95f9565db156cf401b9f462c7b3b768 --- /dev/null +++ b/280/InvasionFront_CD3_block18_x4_y11_patient280_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13043.1, + "Centroid Y µm": 32307.9, + "Num Detections": 12148, + "Num Negative": 11359, + "Num Positive": 789, + "Positive %": 6.495, + "Num Positive per mm^2": 518.07 + } +} \ No newline at end of file diff --git a/280/InvasionFront_CD8_block18_x3_y11_patient280_0.json b/280/InvasionFront_CD8_block18_x3_y11_patient280_0.json new file mode 100644 index 0000000000000000000000000000000000000000..87ee207544c60a7ce1c6651a1b8d866243a088ae --- /dev/null +++ b/280/InvasionFront_CD8_block18_x3_y11_patient280_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11493.9, + "Centroid Y µm": 34806.6, + "Num Detections": 20904, + "Num Negative": 19851, + "Num Positive": 1053, + "Positive %": 5.037, + "Num Positive per mm^2": 469.1 + } +} \ No newline at end of file diff --git a/280/InvasionFront_CD8_block18_x4_y11_patient280_1.json b/280/InvasionFront_CD8_block18_x4_y11_patient280_1.json new file mode 100644 index 0000000000000000000000000000000000000000..37f25cdf7338607063e39f6e0304f79eb12d133c --- /dev/null +++ b/280/InvasionFront_CD8_block18_x4_y11_patient280_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 34756.6, + "Num Detections": 13866, + "Num Negative": 13675, + "Num Positive": 191, + "Positive %": 1.377, + "Num Positive per mm^2": 113.56 + } +} \ No newline at end of file diff --git a/280/TumorCenter_CD3_block18_x3_y11_patient280_0.json b/280/TumorCenter_CD3_block18_x3_y11_patient280_0.json new file mode 100644 index 0000000000000000000000000000000000000000..204651d226ed7c8acbc12cf221650559a6b2ae92 --- /dev/null +++ b/280/TumorCenter_CD3_block18_x3_y11_patient280_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10656.9, + "Centroid Y µm": 26710.9, + "Num Detections": 5679, + "Num Negative": 4198, + "Num Positive": 1481, + "Positive %": 26.08, + "Num Positive per mm^2": 1054.9 + } +} \ No newline at end of file diff --git a/280/TumorCenter_CD3_block18_x4_y11_patient280_1.json b/280/TumorCenter_CD3_block18_x4_y11_patient280_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ebc2a42891f7020b055bbf07d93c360fc2fddd14 --- /dev/null +++ b/280/TumorCenter_CD3_block18_x4_y11_patient280_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13036.8, + "Centroid Y µm": 26798.3, + "Num Detections": 8216, + "Num Negative": 6732, + "Num Positive": 1484, + "Positive %": 18.06, + "Num Positive per mm^2": 927.79 + } +} \ No newline at end of file diff --git a/280/TumorCenter_CD8_block18_x3_y11_patient280_0.json b/280/TumorCenter_CD8_block18_x3_y11_patient280_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c4f54fb38f4c9149b3e6ff57c69777b1657da5e4 --- /dev/null +++ b/280/TumorCenter_CD8_block18_x3_y11_patient280_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10544.4, + "Centroid Y µm": 27585.4, + "Num Detections": 17479, + "Num Negative": 16971, + "Num Positive": 508, + "Positive %": 2.906, + "Num Positive per mm^2": 247.05 + } +} \ No newline at end of file diff --git a/280/TumorCenter_CD8_block18_x4_y11_patient280_1.json b/280/TumorCenter_CD8_block18_x4_y11_patient280_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4ceabfbf4f25284ddeba25ae95a774fca8dcae8e --- /dev/null +++ b/280/TumorCenter_CD8_block18_x4_y11_patient280_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12968.1, + "Centroid Y µm": 27610.4, + "Num Detections": 15979, + "Num Negative": 15495, + "Num Positive": 484, + "Positive %": 3.029, + "Num Positive per mm^2": 272.27 + } +} \ No newline at end of file diff --git a/280/history_text.txt b/280/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e24a07fcadb34302e517fd025033324aa56ca097 --- /dev/null +++ b/280/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma of the vocal fold on the right. According to the pre-pancreas endoscopy, the tumor extends to the anterior commissure. Overview and adjustability not optimal, therefore external surgery indicated. \ No newline at end of file diff --git a/280/icd_codes.txt b/280/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5f0150298b1fa5b9a6154ccc8772dfcd5a39c9ea --- /dev/null +++ b/280/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Neubildung bösartig Plica aryepiglottica laryngis[C32.1 R] \ No newline at end of file diff --git a/280/ops_codes.txt b/280/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dff177eb8da18afbce99e9f2df4b59384f52331d --- /dev/null +++ b/280/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] \ No newline at end of file diff --git a/280/patient_clinical_data.json b/280/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..da8de32df487838a545c562a6e7ba9909ff2be40 --- /dev/null +++ b/280/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 49, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/280/patient_pathological_data.json b/280/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..206f1175ac8a825865049fa787c454a3ddbaf5a7 --- /dev/null +++ b/280/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "280", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/280/surgery_description.txt b/280/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..663a4e8a053e1f866acd5f237259023b0f95c88d --- /dev/null +++ b/280/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection according to Leroux-Robert diff --git a/280/surgery_report.txt b/280/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5336416ee28629f8f181eeac0c1de5e7e6351d3a --- /dev/null +++ b/280/surgery_report.txt @@ -0,0 +1 @@ +Once again, the size C and D small bore tube is used. The tumor is visible from the middle third to just before the commissure. Overall setting suboptimal. Therefore, resection from the outside. Repositioning for laryngeal resection: injection of a total of 8 ml Ultracaine 1% with adrenaline in the prelaryngeal area. Sterile draping after skin disinfection. Z-shaped skin incision. Subsequent exposure of the infrahyoid musculature. This is split medially or dissected to the side. Exposure of the laryngeal skeleton. Formation of a soft tissue perichondrium flap, which is started parapharyngeally on the left and dissected over the front edge of the larynx. Subsequent thyrotomy. Opening of the larynx. The tumor can be seen from the front and reaches just in front of the commissure. Due to the proximity, a small, triangular piece of cartilage is removed from the right side. The perichondrium is then pushed away from the cartilage on the right over the entire length of the vocal fold. This is due to the deep infiltration of the tumor. No breakthrough through the perichondrium. Resection of the vocal fold up to the processus vocalis of the arytenoid cartilage, also including parts of the pocket fold, as the tumor grows somewhat into the ventriculus laryngeus. The tumor is then removed in a specimen. Suture marking. A marginal sample is taken from the left front at the transition to the left vocal fold, another marginal sample from the arytenoid region. Subsequent careful hemostasis. In the frozen section, both tumor and marginal samples in healthy tissue, thus R0 resection. The left vocal fold is now refixed to the cartilage using a 4-0 Vicryl suture. Subsequently, the most careful hemostasis again, no bleeding for a long time after hemostasis and Suprarenin swab insertion. Then suturing of the thyroid cartilage using Vicryl 3-0 sutures. Repositioning of the perichondrium soft tissue flap and suturing to the opposite side with 4-0 Vicryl single-button sutures. Complete closure. Subsequent suturing of the infrahyoid musculature using 3-0 Vicryl single button sutures. This with insertion of a flap. Subsequent layered wound closure. Followed by a light pressure bandage. The procedure was completed without complications. Overall cT1 laryngeal carcinoma, more cT1a than b, but with some proximity to the anterior commissure. Due to the less than optimal overview, resection from the outside. Please arrange another check-up or follow-up MLE in 8 to 12 months. \ No newline at end of file diff --git a/281/InvasionFront_CD3_block21_x3_y4_patient281_0.json b/281/InvasionFront_CD3_block21_x3_y4_patient281_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3f575922dfcc4d9234a8bd5b01e409041080aa8e --- /dev/null +++ b/281/InvasionFront_CD3_block21_x3_y4_patient281_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13992.6, + "Centroid Y µm": 20564.1, + "Num Detections": 13757, + "Num Negative": 13369, + "Num Positive": 388, + "Positive %": 2.82, + "Num Positive per mm^2": 212.49 + } +} \ No newline at end of file diff --git a/281/InvasionFront_CD3_block21_x4_y4_patient281_1.json b/281/InvasionFront_CD3_block21_x4_y4_patient281_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3675b233cc53976edfddeec3119d151f7290265 --- /dev/null +++ b/281/InvasionFront_CD3_block21_x4_y4_patient281_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16566.2, + "Centroid Y µm": 20714.0, + "Num Detections": 9639, + "Num Negative": 9185, + "Num Positive": 454, + "Positive %": 4.71, + "Num Positive per mm^2": 343.58 + } +} \ No newline at end of file diff --git a/281/InvasionFront_CD8_block21_x3_y4_patient281_0.json b/281/InvasionFront_CD8_block21_x3_y4_patient281_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c811cebe46762e874ab5e6cc23342b0b3db10f75 --- /dev/null +++ b/281/InvasionFront_CD8_block21_x3_y4_patient281_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 9944.7, + "Num Detections": 13944, + "Num Negative": 13755, + "Num Positive": 189, + "Positive %": 1.355, + "Num Positive per mm^2": 101.08 + } +} \ No newline at end of file diff --git a/281/InvasionFront_CD8_block21_x4_y4_patient281_1.json b/281/InvasionFront_CD8_block21_x4_y4_patient281_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a6c9e89385d0e7c8fe621815c5d53579e6ffe4ac --- /dev/null +++ b/281/InvasionFront_CD8_block21_x4_y4_patient281_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 9919.7, + "Num Detections": 9293, + "Num Negative": 9042, + "Num Positive": 251, + "Positive %": 2.701, + "Num Positive per mm^2": 211.92 + } +} \ No newline at end of file diff --git a/281/TumorCenter_CD3_block21_x3_y4_patient281_0.json b/281/TumorCenter_CD3_block21_x3_y4_patient281_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dd3a2d5294b3dc673292081a66496748f7be51cd --- /dev/null +++ b/281/TumorCenter_CD3_block21_x3_y4_patient281_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 12718.3, + "Num Detections": 11660, + "Num Negative": 11587, + "Num Positive": 73, + "Positive %": 0.6261, + "Num Positive per mm^2": 34.88 + } +} \ No newline at end of file diff --git a/281/TumorCenter_CD3_block21_x4_y4_patient281_1.json b/281/TumorCenter_CD3_block21_x4_y4_patient281_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c1b2ed722c46ab202ac132dcde75fd4fba37e0c8 --- /dev/null +++ b/281/TumorCenter_CD3_block21_x4_y4_patient281_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 12643.3, + "Num Detections": 8769, + "Num Negative": 8673, + "Num Positive": 96, + "Positive %": 1.095, + "Num Positive per mm^2": 49.75 + } +} \ No newline at end of file diff --git a/281/TumorCenter_CD8_block21_x3_y4_patient281_0.json b/281/TumorCenter_CD8_block21_x3_y4_patient281_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a079d7c65c928c7d348cf8a0666b2dfdab839d2a --- /dev/null +++ b/281/TumorCenter_CD8_block21_x3_y4_patient281_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 25011.8, + "Num Detections": 14831, + "Num Negative": 14807, + "Num Positive": 24, + "Positive %": 0.1618, + "Num Positive per mm^2": 11.77 + } +} \ No newline at end of file diff --git a/281/TumorCenter_CD8_block21_x4_y4_patient281_1.json b/281/TumorCenter_CD8_block21_x4_y4_patient281_1.json new file mode 100644 index 0000000000000000000000000000000000000000..21ff852a778145940743c7c65f9807d61f373936 --- /dev/null +++ b/281/TumorCenter_CD8_block21_x4_y4_patient281_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 24986.8, + "Num Detections": 14357, + "Num Negative": 14328, + "Num Positive": 29, + "Positive %": 0.202, + "Num Positive per mm^2": 14.26 + } +} \ No newline at end of file diff --git a/281/history_text.txt b/281/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..66464d907bd59f611c9b7f288f381f01e4a87c15 --- /dev/null +++ b/281/history_text.txt @@ -0,0 +1 @@ +The patient has had hoarseness for approx. 5 weeks. For this reason, a panendo and sampling of the left vocal fold had already been performed externally in . A moderately differentiated partially keratinizing squamous cell carcinoma of the left vocal fold was diagnosed. The patient had 40 pack years and consumed 3 beers per week. There is an indication for the above-mentioned operation. \ No newline at end of file diff --git a/281/icd_codes.txt b/281/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/281/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/281/ops_codes.txt b/281/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4ed49ece0530585af8069d6ccfa4e835859c9acf --- /dev/null +++ b/281/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Mikrolaryngoskopie[1-610.2 ] Mikrolaryngoskopie mit Resektion eines Larynxtumors[5-300.2 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] \ No newline at end of file diff --git a/281/patient_clinical_data.json b/281/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..42ed34d07c4ca78c67f3851eef814c85d92bcdf8 --- /dev/null +++ b/281/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/281/patient_pathological_data.json b/281/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..80726e071fd4dc14903447d97426ca3cfc1ddda7 --- /dev/null +++ b/281/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "281", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/281/surgery_description.txt b/281/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..206eec9008536a4217c4ad4ad2a560e59632672d --- /dev/null +++ b/281/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Panendoscopy diff --git a/281/surgery_report.txt b/281/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e572cb3193f6f0ccb7328b54d090ef8a0d919b60 --- /dev/null +++ b/281/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater and positioning of the patient. Consultation with the anesthesiologist. Start with inspection of the oral mucosa. This is non-irritating and inconspicuous. The tonsils and base of the tongue are also palpable and clinically unremarkable. The lateral and posterior walls of the pharynx are also unremarkable, as are the cricoid region and both piriform sinuses. The left vocal fold shows a whitish, exophytic mass over the entire length of the vocal fold. Reinke's edema can also be seen. The mass is carefully cut around with the CO2 laser. A swab on the tube protects the cuff, which remains intact. A sufficient safety margin was left anteriorly at the anterior commissure. If the patient is difficult to adjust, it is necessary to switch between the small bore tube C and D and to readjust the tumor several times. However, complete resection of the tumor is possible without any problems. Dorsally, the resection margin extends to the vocalis process, basally to the vocalis muscle. The vocalis muscle can be identified as tumor-free muscle tissue. There is no increased bleeding after resection. Now take 3 marginal samples. These are taken dorsally at the vocal process, basally at the vocalis muscle and caudally at the sedimentation margin or subglottic slope. Insertion of a suprarenal swab. All these marginal samples are tumor-free. Removal of the swab. If there is no bleeding, the operation is ended. Final consultation with the anesthesiologist. Conclusion: The patient has a cT1a glottic carcinoma of the left vocal fold. The final histology should be awaited, the marginal samples were clear today. A follow-up MLE is recommended in 8 weeks. \ No newline at end of file diff --git a/282/InvasionFront_CD3_block20_x3_y3_patient282_0.json b/282/InvasionFront_CD3_block20_x3_y3_patient282_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0a7b28ab5c70e8e5ac97e1bc1e8986cc64b4b6e3 --- /dev/null +++ b/282/InvasionFront_CD3_block20_x3_y3_patient282_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12843.2, + "Centroid Y µm": 7521.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/282/InvasionFront_CD3_block20_x4_y3_patient282_1.json b/282/InvasionFront_CD3_block20_x4_y3_patient282_1.json new file mode 100644 index 0000000000000000000000000000000000000000..46d4680d06f4d8b1586f73cb0a92bbad97e1cf6a --- /dev/null +++ b/282/InvasionFront_CD3_block20_x4_y3_patient282_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15516.8, + "Centroid Y µm": 7745.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/282/InvasionFront_CD8_block20_x3_y3_patient282_0.json b/282/InvasionFront_CD8_block20_x3_y3_patient282_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14751688b4c47cb5a4f0dcad65e1e826aa0df7de --- /dev/null +++ b/282/InvasionFront_CD8_block20_x3_y3_patient282_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11377.3, + "Centroid Y µm": 7704.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/282/InvasionFront_CD8_block20_x4_y3_patient282_1.json b/282/InvasionFront_CD8_block20_x4_y3_patient282_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8fa1e442cd2546e7a2fbc6769759bcc23ff517d5 --- /dev/null +++ b/282/InvasionFront_CD8_block20_x4_y3_patient282_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13951.0, + "Centroid Y µm": 7785.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/282/TumorCenter_CD3_block20_x3_y3_patient282_0.json b/282/TumorCenter_CD3_block20_x3_y3_patient282_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7bf9d1b2b5f21674b14c325e887ccdd8cc42d7b6 --- /dev/null +++ b/282/TumorCenter_CD3_block20_x3_y3_patient282_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11374.7, + "Centroid Y µm": 7054.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/282/TumorCenter_CD3_block20_x4_y3_patient282_1.json b/282/TumorCenter_CD3_block20_x4_y3_patient282_1.json new file mode 100644 index 0000000000000000000000000000000000000000..75bdbbcb50964b6911b7e751adc90af0f9bcbb22 --- /dev/null +++ b/282/TumorCenter_CD3_block20_x4_y3_patient282_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13870.5, + "Centroid Y µm": 7051.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/282/TumorCenter_CD8_block20_x3_y3_patient282_0.json b/282/TumorCenter_CD8_block20_x3_y3_patient282_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7c24f6379009a277109b6a1da87c0e76f4f05363 --- /dev/null +++ b/282/TumorCenter_CD8_block20_x3_y3_patient282_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10569.4, + "Centroid Y µm": 7271.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/282/TumorCenter_CD8_block20_x4_y3_patient282_1.json b/282/TumorCenter_CD8_block20_x4_y3_patient282_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bdb4b23ccd4e783f035bc3004dca89cc07834b3b --- /dev/null +++ b/282/TumorCenter_CD8_block20_x4_y3_patient282_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13068.1, + "Centroid Y µm": 7171.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/282/history_text.txt b/282/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f574bcaff6330b689e57224cf81e34adfab46c52 --- /dev/null +++ b/282/history_text.txt @@ -0,0 +1 @@ +The patient had a pedunculated mass removed from the right supraglottis <2015>. Histology revealed a diagnosis of T1 G3 squamous cell carcinoma. Therefore, the indication for the above-mentioned procedure was given. \ No newline at end of file diff --git a/282/icd_codes.txt b/282/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/282/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/282/ops_codes.txt b/282/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0baa9d08939aff4c803eec56f498fa871a79f058 --- /dev/null +++ b/282/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Mikrolaryngoskopie[1-610.2 ] Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] \ No newline at end of file diff --git a/282/patient_clinical_data.json b/282/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4de58801fffa13a61522fd019f8f369213c2bb34 --- /dev/null +++ b/282/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/282/patient_pathological_data.json b/282/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ce6521f1894dbf383df6882b74e870e312b220cb --- /dev/null +++ b/282/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "282", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/282/surgery_description.txt b/282/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3831ce1f1079bde6ab9dc1093c3c08b47ade1901 --- /dev/null +++ b/282/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection, Neck dissection, and Microlaryngoscopy diff --git a/282/surgery_report.txt b/282/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2296460e9e86659c4001a302bd8a484753ae6e8c --- /dev/null +++ b/282/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, the patient is first positioned by the surgeon. Entry with the Kleinsasser tube. Inspection of the right supraglottis. This reveals a whitish scar in the area of the right aryepiglottic fold where the pedunculated mass was previously located. This scar is resected at a safe distance using the CO2 laser with 5 watts and supra-pulse mode and is marked with sutures for frozen section diagnostics. Lateral, anterior, medial and posterior margin samples are also taken. These are also sent for frozen section diagnostics. Overall, the margin samples are found to be tumor-free, as is the wound bed of the post-resection. Therefore, an R0 resection can now be assumed here. Repositioning for neck dissection on the right. Infiltration anesthesia. Sterile wiping, draping. Skin incision at the level of the sternocleidomastoid muscle. Dissection through the subcutaneous tissue and through the platysma. Creation of a small platysma flap. Dissection of the sternocleidomastoid muscle and exposure of the accessorius nerve. Exposure of the digastric muscle and the omohyoid muscle. Sparing of these structures. Exposure of the cervical vascular sheath with internal jugular vein, carotid artery and vagus nerve. The structures mentioned are spared. Now carefully mobilize the lateral neck preparation. Protect the plexus branches. Now continue dissecting and preparing the anterior neck preparation. Dissect the superior thyroid artery and the facial vein. Exposure of the hypoglossal nerve. All structures are spared. Finally, development of the anterior neck preparation. Irrigation with H2O2 and Ringer's solution. Insertion of a Redon drainage. Two-layer skin closure. Application of a pressure bandage. Repeated inspection of the endolarynx. Bleeding from the area of the wound bed. Therefore, hemostasis with the monopolar. Bleeding stopped. Completion of the procedure without complications. Conclusion: Overall resection in the area of the right supraglottis following removal of a G3 squamous cell carcinoma. Problem-free neck dissection level I b to V. Further procedure after receipt of the final histology and in accordance with our interdisciplinary tumor conference. \ No newline at end of file diff --git a/283/InvasionFront_CD3_block11_x5_y4_patient283_0.json b/283/InvasionFront_CD3_block11_x5_y4_patient283_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b482311b1f74074220d06ba759dd57c0d5c24cb --- /dev/null +++ b/283/InvasionFront_CD3_block11_x5_y4_patient283_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15466.8, + "Centroid Y µm": 9744.8, + "Num Detections": 24583, + "Num Negative": 23305, + "Num Positive": 1278, + "Positive %": 5.199, + "Num Positive per mm^2": 522.54 + } +} \ No newline at end of file diff --git a/283/InvasionFront_CD3_block11_x6_y4_patient283_1.json b/283/InvasionFront_CD3_block11_x6_y4_patient283_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d7892d4cd098e4b05541f3a8bc435fb92316305 --- /dev/null +++ b/283/InvasionFront_CD3_block11_x6_y4_patient283_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17965.5, + "Centroid Y µm": 9694.9, + "Num Detections": 21230, + "Num Negative": 20509, + "Num Positive": 721, + "Positive %": 3.396, + "Num Positive per mm^2": 325.92 + } +} \ No newline at end of file diff --git a/283/InvasionFront_CD8_block11_x5_y4_patient283_0.json b/283/InvasionFront_CD8_block11_x5_y4_patient283_0.json new file mode 100644 index 0000000000000000000000000000000000000000..248de5ea243f944a0661d3b7e92a897a7e13eeb4 --- /dev/null +++ b/283/InvasionFront_CD8_block11_x5_y4_patient283_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18643.5, + "Centroid Y µm": 20573.5, + "Num Detections": 26580, + "Num Negative": 25752, + "Num Positive": 828, + "Positive %": 3.115, + "Num Positive per mm^2": 339.56 + } +} \ No newline at end of file diff --git a/283/InvasionFront_CD8_block11_x6_y4_patient283_1.json b/283/InvasionFront_CD8_block11_x6_y4_patient283_1.json new file mode 100644 index 0000000000000000000000000000000000000000..de83d5b06137f598dda5d2334fbecc69c4e87a50 --- /dev/null +++ b/283/InvasionFront_CD8_block11_x6_y4_patient283_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21185.0, + "Centroid Y µm": 20630.9, + "Num Detections": 11044, + "Num Negative": 11009, + "Num Positive": 35, + "Positive %": 0.3169, + "Num Positive per mm^2": 28.85 + } +} \ No newline at end of file diff --git a/283/TumorCenter_CD3_block11_x5_y4_patient283_0.json b/283/TumorCenter_CD3_block11_x5_y4_patient283_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a12fac4059eb58d6d78c3abad7bf2f580092d952 --- /dev/null +++ b/283/TumorCenter_CD3_block11_x5_y4_patient283_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19439.7, + "Centroid Y µm": 10144.6, + "Num Detections": 23396, + "Num Negative": 22510, + "Num Positive": 886, + "Positive %": 3.787, + "Num Positive per mm^2": 370.32 + } +} \ No newline at end of file diff --git a/283/TumorCenter_CD3_block11_x6_y4_patient283_1.json b/283/TumorCenter_CD3_block11_x6_y4_patient283_1.json new file mode 100644 index 0000000000000000000000000000000000000000..febb80b481120e1a5061af38811418f033a54471 --- /dev/null +++ b/283/TumorCenter_CD3_block11_x6_y4_patient283_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21863.4, + "Centroid Y µm": 10294.5, + "Num Detections": 18127, + "Num Negative": 17770, + "Num Positive": 357, + "Positive %": 1.969, + "Num Positive per mm^2": 161.81 + } +} \ No newline at end of file diff --git a/283/TumorCenter_CD8_block11_x5_y4_patient283_0.json b/283/TumorCenter_CD8_block11_x5_y4_patient283_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d0fafd207bf29158afd0f08f249347a7e33fe24 --- /dev/null +++ b/283/TumorCenter_CD8_block11_x5_y4_patient283_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16891.1, + "Centroid Y µm": 10044.7, + "Num Detections": 23196, + "Num Negative": 22052, + "Num Positive": 1144, + "Positive %": 4.932, + "Num Positive per mm^2": 480.99 + } +} \ No newline at end of file diff --git a/283/TumorCenter_CD8_block11_x6_y4_patient283_1.json b/283/TumorCenter_CD8_block11_x6_y4_patient283_1.json new file mode 100644 index 0000000000000000000000000000000000000000..81e21c27ca682be6f41eb622d9ffbbe49eeec034 --- /dev/null +++ b/283/TumorCenter_CD8_block11_x6_y4_patient283_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19314.8, + "Centroid Y µm": 10119.6, + "Num Detections": 20044, + "Num Negative": 19705, + "Num Positive": 339, + "Positive %": 1.691, + "Num Positive per mm^2": 152.89 + } +} \ No newline at end of file diff --git a/283/history_text.txt b/283/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/283/icd_codes.txt b/283/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0276399877313052c30eeac0b06329304e77b70 --- /dev/null +++ b/283/icd_codes.txt @@ -0,0 +1 @@ +Mischtumor Tonsille[D37.0 ] \ No newline at end of file diff --git a/283/ops_codes.txt b/283/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ddb53266d01fa0409477d75d8e4a2c3c8657ec19 --- /dev/null +++ b/283/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie: Mit starrem Instrument[1-620.1 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Tonsillektomie (ohne Adenotomie): Mit Dissektionstechnik[5-281.0 ] \ No newline at end of file diff --git a/283/patient_clinical_data.json b/283/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ce0dfd7400f10d6532ac8915cd4628db9a80f6c3 --- /dev/null +++ b/283/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/283/patient_pathological_data.json b/283/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..da11634725c8e1517fea5c90157efc21a78ad1b6 --- /dev/null +++ b/283/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "283", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/283/surgery_description.txt b/283/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..222f77582e8bf48dbbae527bde35aa65c9788ce0 --- /dev/null +++ b/283/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy and Tonsillectomy diff --git a/283/surgery_report.txt b/283/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1001ff27e7f195c0155ae40d45decdd9593bd13 --- /dev/null +++ b/283/surgery_report.txt @@ -0,0 +1 @@ +Positioning of the patient by the surgeon at the start of the operation. Tracheoscopy: Inconspicuous mucosal conditions from the glottic level to the carina. No evidence of exophytic tumor growth. Subsequent intubation of the patient by the surgeon without any problems. Esophagoscopy: Under laryngoscopic control, the esophagoscope enters the stomach without any problems. Inconspicuous mucosal conditions can be seen here. Inversion without any problems. On retraction in the area of the lower esophageal sphincter, tongue-like change in the mucosa. An internal examination is certainly advisable here. Further retraction reveals normal mucosal conditions. No evidence of exophytic tumor growth. Laryngoscopy: In the area of the vocal folds on both sides as well as the anterior and posterior commissure and the entire endolarynx, the mucosal conditions are unremarkable. No evidence of exophytic tumor growth. Pharyngoscopy: Both piriform sinuses on both sides as well as the esophageal entrance and the postcricoid region, the posterior pharyngeal wall, the base of the tongue, the uvula as well as the palatal arches and the tonsil on the right side inconspicuous mucosal conditions. No evidence of exophytic tumor growth. The base of the tongue is also free on palpation. In the area of the tonsil on the left side there is a massive enlargement and induration. Tonsillectomy on the left: The tonsil on the left side is massively enlarged and hardened. Mucosal incision in the area of the upper pole and successive release of the tonsil from cranial to caudal. The posterior palatal arch can be spared. A tonsil capsule in the usual sense can hardly be visualized. The borders of the tonsil are heavily scarred. The entire tonsil is now released with careful hemostasis. Careful bipolar coagulation in the area of the lower pole. Separation of the tonsil. Then first hemostasis with the bipolar. The remaining hemostasis is then performed using ................pur. After waiting approx. 2 minutes, the excess powder is rinsed off and suctioned off. After relaxing, check the wound again. No evidence of further bleeding. The operation was completed without bleeding or complications. Conclusion: Internal clarification of a possible mucosal change in the area of the caudal esophageal sphincter recommended. Otherwise unremarkable panendoscopy. Difficult left tonsillectomy for an unclear mass in the tonsil. Resection in healthy tissue cannot be guaranteed beyond doubt. After demonstrating all findings to , a radical resection in the presence of lymphoma was dispensed with. Further procedure depending on the histology. \ No newline at end of file diff --git a/284/InvasionFront_CD3_block10_x3_y2_patient284_0.json b/284/InvasionFront_CD3_block10_x3_y2_patient284_0.json new file mode 100644 index 0000000000000000000000000000000000000000..597e957eba7e397fcc8466005db5d86929239fc4 --- /dev/null +++ b/284/InvasionFront_CD3_block10_x3_y2_patient284_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14299.2, + "Centroid Y µm": 10252.6, + "Num Detections": 16797, + "Num Negative": 16233, + "Num Positive": 564, + "Positive %": 3.358, + "Num Positive per mm^2": 275.87 + } +} \ No newline at end of file diff --git a/284/InvasionFront_CD3_block10_x4_y2_patient284_1.json b/284/InvasionFront_CD3_block10_x4_y2_patient284_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b323d9abcc668ee0c45f2b235f513373a175911 --- /dev/null +++ b/284/InvasionFront_CD3_block10_x4_y2_patient284_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16691.2, + "Centroid Y µm": 10419.5, + "Num Detections": 16023, + "Num Negative": 15844, + "Num Positive": 179, + "Positive %": 1.117, + "Num Positive per mm^2": 90.96 + } +} \ No newline at end of file diff --git a/284/InvasionFront_CD8_block10_x3_y2_patient284_0.json b/284/InvasionFront_CD8_block10_x3_y2_patient284_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee3c0ea06cb6b92c34e21df569503dda0cb0cc00 --- /dev/null +++ b/284/InvasionFront_CD8_block10_x3_y2_patient284_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13168.0, + "Centroid Y µm": 10344.5, + "Num Detections": 18372, + "Num Negative": 17370, + "Num Positive": 1002, + "Positive %": 5.454, + "Num Positive per mm^2": 483.53 + } +} \ No newline at end of file diff --git a/284/InvasionFront_CD8_block10_x4_y2_patient284_1.json b/284/InvasionFront_CD8_block10_x4_y2_patient284_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bbdbe486fa4f2d71b6a3f2d41c2b3c52a6038970 --- /dev/null +++ b/284/InvasionFront_CD8_block10_x4_y2_patient284_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15591.7, + "Centroid Y µm": 10394.5, + "Num Detections": 16910, + "Num Negative": 16706, + "Num Positive": 204, + "Positive %": 1.206, + "Num Positive per mm^2": 103.75 + } +} \ No newline at end of file diff --git a/284/TumorCenter_CD3_block10_x3_y2_patient284_0.json b/284/TumorCenter_CD3_block10_x3_y2_patient284_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b360bc67a3f26efc1e8d35b49d22c2fb00b3f862 --- /dev/null +++ b/284/TumorCenter_CD3_block10_x3_y2_patient284_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 5122.3, + "Num Detections": 14021, + "Num Negative": 13803, + "Num Positive": 218, + "Positive %": 1.555, + "Num Positive per mm^2": 116.26 + } +} \ No newline at end of file diff --git a/284/TumorCenter_CD3_block10_x4_y2_patient284_1.json b/284/TumorCenter_CD3_block10_x4_y2_patient284_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eaab643210c18c478578de324484ca6cfd3ea402 --- /dev/null +++ b/284/TumorCenter_CD3_block10_x4_y2_patient284_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 4972.4, + "Num Detections": 13806, + "Num Negative": 13771, + "Num Positive": 35, + "Positive %": 0.2535, + "Num Positive per mm^2": 18.39 + } +} \ No newline at end of file diff --git a/284/TumorCenter_CD8_block10_x3_y2_patient284_0.json b/284/TumorCenter_CD8_block10_x3_y2_patient284_0.json new file mode 100644 index 0000000000000000000000000000000000000000..843bb7810a345e4dc1990e0378c0c9efef06873f --- /dev/null +++ b/284/TumorCenter_CD8_block10_x3_y2_patient284_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10594.4, + "Centroid Y µm": 5647.0, + "Num Detections": 15720, + "Num Negative": 15478, + "Num Positive": 242, + "Positive %": 1.539, + "Num Positive per mm^2": 129.94 + } +} \ No newline at end of file diff --git a/284/TumorCenter_CD8_block10_x4_y2_patient284_1.json b/284/TumorCenter_CD8_block10_x4_y2_patient284_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8572b2504e8248f841c83ec816151d6f473934f7 --- /dev/null +++ b/284/TumorCenter_CD8_block10_x4_y2_patient284_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13018.1, + "Centroid Y µm": 5472.1, + "Num Detections": 15976, + "Num Negative": 15934, + "Num Positive": 42, + "Positive %": 0.2629, + "Num Positive per mm^2": 22.14 + } +} \ No newline at end of file diff --git a/284/history_text.txt b/284/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8cf9263b6a36cd7847b805b319782cd835b21078 --- /dev/null +++ b/284/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed large hypopharyngeal carcinoma on the right with invasion into the larynx. Laryngectomy, partial pharyngectomy, possibly with flap coverage, therefore indicated. \ No newline at end of file diff --git a/284/icd_codes.txt b/284/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ced9ea13e026fcf7321427cdf107ec08354a474e --- /dev/null +++ b/284/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] Fibrose durch Gefäßprothese[T82.8 ] \ No newline at end of file diff --git a/284/ops_codes.txt b/284/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e11b12a089d6d2e51c3456b64566de05c8419d36 --- /dev/null +++ b/284/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, erweitert: 5 Regionen[5-403.31 R] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 4 Regionen[5-403.03 L] Laryngektomie: Mit Pharyngektomie und Schilddrüsenresektion: Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.24 ] Oberschenkel und Knie[5-858.78 R] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/284/patient_clinical_data.json b/284/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..529fcccf374ce6986bd06afe5306eb6ab03d3e4e --- /dev/null +++ b/284/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 47, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/284/patient_pathological_data.json b/284/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6809b9c1419124751bad5c77af56fafc143e89ff --- /dev/null +++ b/284/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "284", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 51, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 45.0 +} \ No newline at end of file diff --git a/284/surgery_description.txt b/284/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c4b1294a02d12c1408bc5b0460ba40f67c5f957f --- /dev/null +++ b/284/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy with total pharyngectomy, Right thyroid resection, Bilateral neck dissection, Defect coverage for esophagus replacement, Free flap (ALT) diff --git a/284/surgery_report.txt b/284/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..075ec2f676766f7593c87947708de61ce7977750 --- /dev/null +++ b/284/surgery_report.txt @@ -0,0 +1 @@ +First laryngoscopy and pharyngoscopy: The large, exophytic tumor is visible, which extends to the midline of the posterior wall of the hypopharynx on the right and breaks into the larynx via the lateral wall/anterior wall. The tumor cannot be reliably demarcated caudally from the esophageal entrance. Due to the extent of the tumor, flap coverage is indicated in any case. Due to the uncertain vascular situation in the area of the forearms, bilateral coverage of the thigh area on the right. Start with neck dissection on both sides: creation of an apron flap in the typical manner up to the level of the submandibular gland and hyoid bone. Followed by neck dissection on the left. Detachment of the fat lymph node package from the sternocleidomastoid muscle. Exposure of the omohyoid muscle, digastric muscle. Exposure of the cervical vascular sheath, internal jugular vein, internal and external carotid artery. Exposure of the hypoglossal nerve, vagus nerve and accessorius nerve. Development of the dorsal neck preparation and preservation of the branches of the cervical plexus. Subsequent development of the anterior neck preparation and preservation of the hypoglossal nerve, facial vein and superior thyroid artery. Overall evacuation level II to V. Now radical neck dissection on the right: tumor conglomerate in the upper neck area infiltrates the sternocleidomastoid muscle and internal jugular vein. Therefore removal of the sternocleidomastoid muscle cranially and caudally. Separation of the accessorius nerve. Separation of the internal jugular vein and double ligation cranially and caudally by means of puncture and single ligation. Tumor conglomerate can be dissected from the common carotid artery and external carotid artery as well as the branches and the hypoglossal nerve. Detachment of the tumor from the external carotid artery branches and the subglottis is sometimes difficult. It can be seen that the tumor is connected to the thyroid gland. There is a risk of infiltration here. Therefore, the tumor conglomerate on the right lobe of the thyroid gland is left as a per continuitatem resection. The remaining level II to V areas are typically removed here. Subsequent tumor resection: First detachment of suprahyoid muscles from the hyoid bone including the pre-epiglottic fatty tissue. Detachment of the constrictor pharyngis muscle from the left superior cornu. Separating piriform sinus. Entering the pharynx cranially. Incision of the tumor with a safety margin of at least 1.5 m to 2 cm on all sides. Resection includes hypopharynx, a residual pharyngeal strip of 2 cm remains in the middle area. The tumor extends caudally to the esophageal entrance and is removed here with a safety margin of approx. 1 cm. The tumor is then removed caudally. Marginal samples are taken from the hypopharyngeal margin on the right and left and from the caudal margin in the area of the esophageal entrance. All marginal samples and the tumor are sent to the frozen section for assessment. Frozen section in the area of the esophageal inlet free. Infiltrates still in the area of the posterior wall of the hypopharynx. Here again resection and submission of a mucosal strip, which is thread-marked for frozen section examination. Here again in situ infiltrates buccally. Due to the small width of the remaining strip, which is less than 1 cm in some cases, the remaining pharynx is now resected from the transition to the oropharynx to the esophageal entrance. The resectate is suture-marked for final assessment. Total pharyngectomy and indication for flap coverage using a thigh flap. The thigh flap is now elevated: first mark the flap size, which is 11.5 cm in length and 10 or 8 cm in width. Also Doppler mark the perforators. The flap is drawn around the perforators. Then first cut around medially. Exposure of the rectus femoris muscle and vastus lateralis muscle. Subfascial dissection up to the intermuscular septum. Subsequent cranial exposure of the vascular pedicle. The ramus descendens and 2 accompanying veins can be visualized as well as 2 accompanying nerves that run into the vastus lateralis. No special features cranially in the vascular pedicle area. Then cut around the flap to the fascia from the medial side. The vascular pedicle is deposited caudally. Then successive elevation of the flap together with parts of the vastus lateralis muscle and preservation of the level of the septo-musculocutaneous perforators. Finally, perforation of the cross-section up to the exit from the profunda brachii artery. Here, the artery and a total of one larger and one smaller accompanying vein are removed. Proximal vascular stumps are ligated using puncture ligatures 400 Prolene. Finally, after careful hemostasis, wound closure in layers with mobilization of the skin and insertion of Redon drains. Primary skin closure is possible. The flap is then sutured into the defect. Flap is sutured into the defect using 3/0 Vicryl single-button sutures, in some cases after the sutures have been placed, initially caudally and then also cranially. Esophageal access plasty is performed caudally. A myotomy was also performed here beforehand. Passage is easily possible with a transverse finger. Anastomosis and pharyngoplasty are performed with little tension. Muscle parts of the vastus lateralis are placed over the suture of the flap. A larger outlet from the right external carotid artery and the right external jugular vein are then trimmed and conditioned. The vessels of the flap pedicle are also conditioned. The descending ramus is then sutured to the exit from the external carotid artery using 8/0 single-button ethilon sutures. Here, after opening the clamp, good venous return. The vein size is then measured. A 3/0 coupler is selected. This is used to create the anastomosis between the external jugular vein and the larger of the two veins of the flap pedicle. After opening the clamp, good reflux, alignment test positive. The remaining vein is clipped. The outflows from the external crus, which occurred after removal of the anastomotic vessel, are ligated. Overall good flap perfusion, good arterial flow and venous return. Careful hemostasis of the entire wound area is now performed. Irrigation. Then wound closure in layers with epithelialization of the tracheostoma and insertion of a Redon drain on each side. Subsequent marking of the vessels for Doppler control. Insertion of a tracheostomy tube, which is sutured in place. No dressing is applied. Patient goes to the intensive care unit for postoperative monitoring. The antibiotic treatment with Unacid 3 g started intraoperatively should be continued postoperatively for 1 week with 3 x 1.5 g i.v. nutrition via the PEG for at least 10 days, followed by gruel and, if necessary, a diet. The inserted gastric tube can then also be removed. Please continue heparin perfusor with 500 units per hour for 3 days. Overall, extensive hypopharyngeal tumor with invasion into the larynx and extensive lymph node metastasis, especially on the right side. Postoperative radio-chemotherapy is certainly indicated if the patient can tolerate it due to the concomitant disease. \ No newline at end of file diff --git a/285/InvasionFront_CD3_block2_x5_y12_patient285_0.json b/285/InvasionFront_CD3_block2_x5_y12_patient285_0.json new file mode 100644 index 0000000000000000000000000000000000000000..764c17f581c252e35383a1fa4dc4c9a9e35ca0f2 --- /dev/null +++ b/285/InvasionFront_CD3_block2_x5_y12_patient285_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18290.3, + "Centroid Y µm": 43701.9, + "Num Detections": 18170, + "Num Negative": 16524, + "Num Positive": 1646, + "Positive %": 9.059, + "Num Positive per mm^2": 747.05 + } +} \ No newline at end of file diff --git a/285/InvasionFront_CD3_block2_x6_y12_patient285_1.json b/285/InvasionFront_CD3_block2_x6_y12_patient285_1.json new file mode 100644 index 0000000000000000000000000000000000000000..72b74a6753723058600ddbd715ecfa070d79fe87 --- /dev/null +++ b/285/InvasionFront_CD3_block2_x6_y12_patient285_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20864.0, + "Centroid Y µm": 43701.9, + "Num Detections": 22062, + "Num Negative": 18785, + "Num Positive": 3277, + "Positive %": 14.85, + "Num Positive per mm^2": 1342.3 + } +} \ No newline at end of file diff --git a/285/InvasionFront_CD8_block2_x5_y12_patient285_0.json b/285/InvasionFront_CD8_block2_x5_y12_patient285_0.json new file mode 100644 index 0000000000000000000000000000000000000000..654c186dcfcc5001d7a7845db0ad491810aafa49 --- /dev/null +++ b/285/InvasionFront_CD8_block2_x5_y12_patient285_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 31258.4, + "Num Detections": 22986, + "Num Negative": 21361, + "Num Positive": 1625, + "Positive %": 7.07, + "Num Positive per mm^2": 633.01 + } +} \ No newline at end of file diff --git a/285/InvasionFront_CD8_block2_x6_y12_patient285_1.json b/285/InvasionFront_CD8_block2_x6_y12_patient285_1.json new file mode 100644 index 0000000000000000000000000000000000000000..010d91bc54e1e320cf567346bf5cc636af8fa948 --- /dev/null +++ b/285/InvasionFront_CD8_block2_x6_y12_patient285_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19564.6, + "Centroid Y µm": 31308.4, + "Num Detections": 21109, + "Num Negative": 18207, + "Num Positive": 2902, + "Positive %": 13.75, + "Num Positive per mm^2": 1219.3 + } +} \ No newline at end of file diff --git a/285/TumorCenter_CD3_block2_x5_y12_patient285_0.json b/285/TumorCenter_CD3_block2_x5_y12_patient285_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8e71fb5ce5b36598c09019d1660f14b8dd1bb77e --- /dev/null +++ b/285/TumorCenter_CD3_block2_x5_y12_patient285_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15491.8, + "Centroid Y µm": 29759.2, + "Num Detections": 19665, + "Num Negative": 15626, + "Num Positive": 4039, + "Positive %": 20.54, + "Num Positive per mm^2": 1715.9 + } +} \ No newline at end of file diff --git a/285/TumorCenter_CD3_block2_x6_y12_patient285_1.json b/285/TumorCenter_CD3_block2_x6_y12_patient285_1.json new file mode 100644 index 0000000000000000000000000000000000000000..68b0e58d962c5f9635dd2f5f5ca1abe72a9fec06 --- /dev/null +++ b/285/TumorCenter_CD3_block2_x6_y12_patient285_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17990.5, + "Centroid Y µm": 29909.2, + "Num Detections": 21983, + "Num Negative": 20831, + "Num Positive": 1152, + "Positive %": 5.24, + "Num Positive per mm^2": 461.41 + } +} \ No newline at end of file diff --git a/285/TumorCenter_CD8_block2_x5_y12_patient285_0.json b/285/TumorCenter_CD8_block2_x5_y12_patient285_0.json new file mode 100644 index 0000000000000000000000000000000000000000..88b3da88db696d4e11243dcf13536ecec3e54017 --- /dev/null +++ b/285/TumorCenter_CD8_block2_x5_y12_patient285_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18315.3, + "Centroid Y µm": 29609.3, + "Num Detections": 15967, + "Num Negative": 13058, + "Num Positive": 2909, + "Positive %": 18.22, + "Num Positive per mm^2": 1325.6 + } +} \ No newline at end of file diff --git a/285/TumorCenter_CD8_block2_x6_y12_patient285_1.json b/285/TumorCenter_CD8_block2_x6_y12_patient285_1.json new file mode 100644 index 0000000000000000000000000000000000000000..da84cccdfd96409992c75e5e585c21ffbb8ff1dc --- /dev/null +++ b/285/TumorCenter_CD8_block2_x6_y12_patient285_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20789.0, + "Centroid Y µm": 29509.4, + "Num Detections": 18104, + "Num Negative": 17775, + "Num Positive": 329, + "Positive %": 1.817, + "Num Positive per mm^2": 137.6 + } +} \ No newline at end of file diff --git a/285/history_text.txt b/285/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a05c6e4ead80d87b1a13b97ec634443f3e3ce45 --- /dev/null +++ b/285/history_text.txt @@ -0,0 +1 @@ +The patient's panendoscopy <2015> confirmed a cT2 cN0 cM0 uvular carcinoma that had already been confirmed externally. In our interdisciplinary tumor conference, the primary surgical procedure was recommended. The patient had clear pre-existing conditions with liver cirrhosis, diabetes mellitus, COPD and ethyltoxic polyneuropathy. \ No newline at end of file diff --git a/285/icd_codes.txt b/285/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc812a96bf6c5b11e6e0b30f5050412ad9dba306 --- /dev/null +++ b/285/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Gaumen, mehrere Teilbereiche überlappend[C05.8 ] \ No newline at end of file diff --git a/285/ops_codes.txt b/285/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..389f9fd512b6b574bda9f6660263d348ccab2fff --- /dev/null +++ b/285/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Vollhaut Entnahmestelle Leisten- und Genitalregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Kontinuierliche Sogbehandlung mit sonstigen Systemen bei einer Vakuumtherapie an bis zu 7 Tagen[8-190.30 ] \ No newline at end of file diff --git a/285/patient_clinical_data.json b/285/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2ea8c01c9b07b4459c8d80de80f044b3bfa7d00f --- /dev/null +++ b/285/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 43, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/285/patient_pathological_data.json b/285/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ef2151d532e1cc01989cf6fa838188830dafaf66 --- /dev/null +++ b/285/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "285", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 32, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/285/surgery_description.txt b/285/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..32747a3dfa56f0be3d3c42c2c70834da6d747337 --- /dev/null +++ b/285/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Defect reconstruction, Free flap (Radial), Neck dissection diff --git a/285/surgery_report.txt b/285/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e814d1cd790e9a036466c9e549e21e8e30d1aa18 --- /dev/null +++ b/285/surgery_report.txt @@ -0,0 +1 @@ +After transnasal intubation and preparation by the anesthesia colleagues, the patient is positioned. First inspection of the primary tumor region. As described above, the exophytic mass can be seen here, which completely occupies and consumes the uvula, clearly infiltrates the base of the uvula submucosally and extends over the soft palate in the direction of both upper tonsil poles, slightly shifted to the right with extensions to the anterior and posterior palatal arch on the left side. The tumor is now cut around with a good one cm safety margin. All sides of the left cranial tonsil pole are removed. Subtotal resection of the soft palate and for later graft positioning, performing a right tonsillectomy during tumor resection with partial resection of the posterior palatal arch on the right. The tumor is thread-marked for frozen section diagnostics and is shown here completely resected on the specimen in sano. Hemostasis and measurement of the defect. Neck dissection is performed first. A nasogastric feeding tube was inserted beforehand. Due to good short-term and long-term swallowing prognosis and cirrhosis of the liver, no PEG was inserted. Start with neck dissection on the left side. Submandibular incision. Cutting through skin and subcutaneous tissue. Exposure, transection and dissection of the platysma. Exposure of the sternocleidomastoid muscle and preservation of the external jugular vein and auricular nerve. Exposure of the omohyoid muscle. Release of the submandibular gland, taking the caudal capsule with it. Exposure of the digastric muscle and preservation of the facial vein. Removal of the anterior neck preparation with exposure and preservation of the superior thyroid artery, the cervical artery and the hypoglossal nerve. Free preparation of the internal jugular vein. Exposure of the accessorius nerve. Clearance of the posterior neck preparation, limiting the neck extension towards level V. Exposure and preservation of the cervical plexus roots. Exposure of the common carotid artery and the vagus nerve. Macroscopically no evidence of metastasis on this side. Wound irrigation with Ringer's solution, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Turn to the opposite side. Same procedure here in principle. Extension of the expansion in the direction of the accessorius triangle and, after level V, complete exposure and removal of the structures already described on the opposite side. No evidence of lymphogenic metastasis. Strong vascular condition. Dissection and conditioning of the superior thyroid artery and the clearly branched facial vein. Resection of the digastric muscle. Formation of a pharyngocutaneous connection approx. 3 transverse fingers wide for graft positioning. Careful hemostasis. Then lift the radialis graft from the left. Perform the elevation in bloodlessness. Marking of a graft measuring 12 x 5.5 cm in total, confluent for the tonsil region and soft tissue. Radial incision. Incision of the graft. Exposure of the brachioradialis muscle. Exposing and securing the ramus superficialis nervi radialis. Distal exposure and transection of the vascular pedicle. Strictly subfascial release. Exposure of the flexor carpi ulnaris muscle. Elevation of the graft. Conditioning on the vascular pedicle. Exposure of the radial artery and securing of the ulnar artery. Dissection of the venous confluence and conditioning on a strong vein of the deep venous system with connection to the superficial. Reopening of the tourniquet. Regular blood flow to the hand and regular blood flow to the graft. Careful hemostasis in the area of the graft and in the area of the forearm. Subsequently, after removal of the preparation, careful two-layer wound closure and incorporation of the full-thickness skin graft harvested from the right groin. Subsequent positioning of the graft enorally. Successive transoral insertion. Overall good fit and sufficient soft palate reconstruction. Pedicle positioning. Performing the arterial anastomosis with 8.0 Ethilon, after conditioning the pedicle vessels. Performing the venous anastomosis with the coupler system using a size 4.0 coupler. Subsequent correct pedicle position. Positive spreading phenomenon and regular enoral graft perfusion, so that after careful wound inspection, a 10 Redon drain is inserted and the wound is carefully closed in two layers. A tracheotomy was not performed due to the completely narrow enoral conditions. The patient is transferred to the intensive care unit for one night on mechanical ventilation. Conclusion: Intraoperatively in sano resected cT2 cN0 uvular carcinoma. Postoperative careful graft monitoring. If the graft heals properly, a gradual diet can be started on the 7th postoperative day. Please continue antibiotics for 24 hours. Presentation at our interdisciplinary tumor conference to discuss adjuvant therapy. \ No newline at end of file diff --git a/286/InvasionFront_CD3_block6_x5_y12_patient286_0.json b/286/InvasionFront_CD3_block6_x5_y12_patient286_0.json new file mode 100644 index 0000000000000000000000000000000000000000..23d5b7d962b41c03edd3dfe4e9fa88c50e8b3431 --- /dev/null +++ b/286/InvasionFront_CD3_block6_x5_y12_patient286_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 31583.3, + "Num Detections": 17137, + "Num Negative": 16395, + "Num Positive": 742, + "Positive %": 4.33, + "Num Positive per mm^2": 333.43 + } +} \ No newline at end of file diff --git a/286/InvasionFront_CD3_block6_x6_y12_patient286_1.json b/286/InvasionFront_CD3_block6_x6_y12_patient286_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f9aa646a1652115011828a9a1daa7120f8db5da --- /dev/null +++ b/286/InvasionFront_CD3_block6_x6_y12_patient286_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 31683.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/286/InvasionFront_CD8_block6_x5_y10_patient286_0.json b/286/InvasionFront_CD8_block6_x5_y10_patient286_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3ba4205eb284b9b8ed6a4e344c68bd7ee1c8a576 --- /dev/null +++ b/286/InvasionFront_CD8_block6_x5_y10_patient286_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 25536.5, + "Num Detections": 8356, + "Num Negative": 8311, + "Num Positive": 45, + "Positive %": 0.5385, + "Num Positive per mm^2": 27.34 + } +} \ No newline at end of file diff --git a/286/InvasionFront_CD8_block6_x6_y10_patient286_1.json b/286/InvasionFront_CD8_block6_x6_y10_patient286_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f829a7e18be967065bd7c2b026b1ebbcbbb3b8a1 --- /dev/null +++ b/286/InvasionFront_CD8_block6_x6_y10_patient286_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19514.7, + "Centroid Y µm": 25736.4, + "Num Detections": 5949, + "Num Negative": 5935, + "Num Positive": 14, + "Positive %": 0.2353, + "Num Positive per mm^2": 7.653 + } +} \ No newline at end of file diff --git a/286/TumorCenter_CD3_block6_x5_y10_patient286_0.json b/286/TumorCenter_CD3_block6_x5_y10_patient286_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08bd3b787617dd74c98774e36b759d056cabccbc --- /dev/null +++ b/286/TumorCenter_CD3_block6_x5_y10_patient286_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 25386.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/286/TumorCenter_CD3_block6_x6_y10_patient286_1.json b/286/TumorCenter_CD3_block6_x6_y10_patient286_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bad5d408bd55aca39710debebb3ea76ee033ee6d --- /dev/null +++ b/286/TumorCenter_CD3_block6_x6_y10_patient286_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 25436.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/286/TumorCenter_CD8_block6_x5_y10_patient286_0.json b/286/TumorCenter_CD8_block6_x5_y10_patient286_0.json new file mode 100644 index 0000000000000000000000000000000000000000..198405b8ad66a9af68a380bcd156f5a783085b0a --- /dev/null +++ b/286/TumorCenter_CD8_block6_x5_y10_patient286_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 25736.4, + "Num Detections": 13048, + "Num Negative": 12915, + "Num Positive": 133, + "Positive %": 1.019, + "Num Positive per mm^2": 85.75 + } +} \ No newline at end of file diff --git a/286/TumorCenter_CD8_block6_x6_y10_patient286_1.json b/286/TumorCenter_CD8_block6_x6_y10_patient286_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e233d8a58323a85064a9804ebb71674010410845 --- /dev/null +++ b/286/TumorCenter_CD8_block6_x6_y10_patient286_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 26011.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/286/history_text.txt b/286/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c1d6f5f10007aa5c9108e9890de46793caef2a8e --- /dev/null +++ b/286/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed right tonsil squamous cell carcinoma. Preoperative extent determined. Tumor extends from the anterior palatal arch over the pharyngeal wall into the base of the tongue on the right. Therefore indication for the above-mentioned operation. \ No newline at end of file diff --git a/286/icd_codes.txt b/286/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/286/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/286/ops_codes.txt b/286/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8150bc564b8e6fb4a35b948e09fa33c61bc7e6b --- /dev/null +++ b/286/ops_codes.txt @@ -0,0 +1 @@ +Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument[1-620.1 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Tonsillektomie (ohne Adenotomie): Radikal, transoral[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 L] \ No newline at end of file diff --git a/286/patient_clinical_data.json b/286/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0bddc7354db5c238ee55d50d3329a45d2f367b27 --- /dev/null +++ b/286/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 42, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/286/patient_pathological_data.json b/286/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..74662af1c4031a78e227137f032777f5e17ac34b --- /dev/null +++ b/286/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "286", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/286/surgery_description.txt b/286/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7295f614adee4e24e7c26807b821b015679ca5c0 --- /dev/null +++ b/286/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection on the right, Modified radical left neck dissection, PEG, Tracheotomy diff --git a/286/surgery_report.txt b/286/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c353236165cf7ebdc1b56035a9a9b5f17eb08223 --- /dev/null +++ b/286/surgery_report.txt @@ -0,0 +1 @@ +First transoral tumor resection: Firstly, bridle suture of the tongue. Followed by Mc Ivor spatula or retractor insertion. Tumor is resected on all sides with a safety margin of 1 to 1.5 cm. Later, the anterior palatal arch, the tonsil and parts of the pharyngeal wall and the base of the tongue up to the middle of the tongue are also resected. During resection, the deep external tongue muscles are also resected; the lingual nerve cannot be preserved and must be resected as well. The resection extends deep down to the submandibular gland. The entire preparation is marked with sutures. In addition, frozen sections are taken basally. Parts of the pharyngeal wall and the submandibular gland as well as external tongue muscles are sent in as basal margin samples for the frozen section. In the frozen section, basal margin samples are tumor-free, but the tumor extends at least as far as the cranial edge of the specimen. Therefore, the cranial mucosa including soft tissue is resected again. In addition, a cranial margin sample is taken from the soft tissue area. Now tumor-free in the frozen section. Thus R0 situation. Subsequent careful hemostasis in the entire wound area. Fatty tissue is already partially exposed next to the pharyngeal muscles. The submandibular gland and the facial artery are exposed caudally. The facial artery is ligated once. Muscle tissue is then sutured over the gland and the facial artery using Vicryl 3/0 sutures. Finally, irrigation and further careful hemostasis. No more bleeding on final inspection. No neck dissection on the right due to the extent of the resection on the right. The decision is made to perform the left neck dissection first. PEG placement and tracheostomy are also indicated. First modified radical neck dissection on the left (, in alternation) Skin incision in a typical manner in front of the sternocleidomastoid muscle. Then dissection of the lymph node fat packet from the sternocleidomastoid muscle. Exposure of the digastric and omohyoid muscles. Exposure of the accessor nerve, internal jugular vein, internal and external carotid artery, vagus nerve and hypoglossal nerve. Development of the dorsal neck preparation and preservation of the branches of the cervical plexus. Some conspicuous lymph nodes. Then develop the anterior neck preparation, exposing and preserving the hypoglossal nerve and superior thyroid artery. Then irrigation of the wound area with H2O2 and Ringer's solution and careful hemostasis. Wound closure in layers and insertion of a Redon drain. Subsequent PEG insertion: advancement of the esophagoscope into the stomach. Insertion of a 9-bore abdominal wall tube in a typical manner without complications. Fixation to the abdominal wall in a typical manner. Then tracheostoma creation: Small Kocher collar incision. Dissection through subcutaneous tissue to the infrahyoid musculature. This is split medially. Subsequently expose the thyroid isthmus, pass under it, clamp it, cut it open and treat it with stitches. Now expose the trachea. Entering the 2nd intercartilaginous space. Creation of a small Björk flap. Epithelialization of the same. Re-intubation and insertion of an 8 mm tracheal cannula. Finally, enoral inspection again. No bleeding. Completion of the procedure without complications. Patient admitted to the intensive care unit for postoperative monitoring. Overall extensive resection transorally for cT2 to cT3 oropharyngeal carcinoma on the right. Due to the depth, neck dissection is certainly not indicated for another 2 to 3 weeks. If there is an R1 situation somewhere towards the basal area, a resection with flap coverage would be indicated. If neck dissection remains the case, removal of the submandibular gland should not be performed in any case, as otherwise there is a risk of a continuous defect. \ No newline at end of file diff --git a/287/InvasionFront_CD3_block4_x3_y2_patient287_0.json b/287/InvasionFront_CD3_block4_x3_y2_patient287_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c32f7be3cf290261350cce16d029beada11deae2 --- /dev/null +++ b/287/InvasionFront_CD3_block4_x3_y2_patient287_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14149.0, + "Centroid Y µm": 11550.2, + "Num Detections": 6300, + "Num Negative": 5910, + "Num Positive": 390, + "Positive %": 6.19, + "Num Positive per mm^2": 465.57 + } +} \ No newline at end of file diff --git a/287/InvasionFront_CD3_block4_x4_y2_patient287_1.json b/287/InvasionFront_CD3_block4_x4_y2_patient287_1.json new file mode 100644 index 0000000000000000000000000000000000000000..20948db40d8be9ce45a51a68b2f2336f9f97fb5e --- /dev/null +++ b/287/InvasionFront_CD3_block4_x4_y2_patient287_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16691.2, + "Centroid Y µm": 11505.4, + "Num Detections": 18857, + "Num Negative": 18222, + "Num Positive": 635, + "Positive %": 3.367, + "Num Positive per mm^2": 296.14 + } +} \ No newline at end of file diff --git a/287/InvasionFront_CD8_block4_x3_y2_patient287_0.json b/287/InvasionFront_CD8_block4_x3_y2_patient287_0.json new file mode 100644 index 0000000000000000000000000000000000000000..26a4507cb6aeabc697b67f7c0a61d2efb63f7248 --- /dev/null +++ b/287/InvasionFront_CD8_block4_x3_y2_patient287_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11456.4, + "Centroid Y µm": 9844.8, + "Num Detections": 6279, + "Num Negative": 6024, + "Num Positive": 255, + "Positive %": 4.061, + "Num Positive per mm^2": 296.51 + } +} \ No newline at end of file diff --git a/287/InvasionFront_CD8_block4_x4_y2_patient287_1.json b/287/InvasionFront_CD8_block4_x4_y2_patient287_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b959054b9197ef9ad017809b04708e110122024 --- /dev/null +++ b/287/InvasionFront_CD8_block4_x4_y2_patient287_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13994.7, + "Centroid Y µm": 9949.4, + "Num Detections": 17751, + "Num Negative": 17357, + "Num Positive": 394, + "Positive %": 2.22, + "Num Positive per mm^2": 179.66 + } +} \ No newline at end of file diff --git a/287/TumorCenter_CD3_block4_x3_y2_patient287_0.json b/287/TumorCenter_CD3_block4_x3_y2_patient287_0.json new file mode 100644 index 0000000000000000000000000000000000000000..36d6b107bfd3d7cb63bff9d7d78452eae36fbaae --- /dev/null +++ b/287/TumorCenter_CD3_block4_x3_y2_patient287_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 5222.2, + "Num Detections": 21068, + "Num Negative": 18734, + "Num Positive": 2334, + "Positive %": 11.08, + "Num Positive per mm^2": 1038.7 + } +} \ No newline at end of file diff --git a/287/TumorCenter_CD3_block4_x4_y2_patient287_1.json b/287/TumorCenter_CD3_block4_x4_y2_patient287_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d63e2e433f3afc26df1ef11852a981e2503b8f95 --- /dev/null +++ b/287/TumorCenter_CD3_block4_x4_y2_patient287_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 5222.2, + "Num Detections": 19302, + "Num Negative": 18475, + "Num Positive": 827, + "Positive %": 4.285, + "Num Positive per mm^2": 363.44 + } +} \ No newline at end of file diff --git a/287/TumorCenter_CD8_block4_x3_y2_patient287_0.json b/287/TumorCenter_CD8_block4_x3_y2_patient287_0.json new file mode 100644 index 0000000000000000000000000000000000000000..304fddddb1d68e255082507189e20ccc8cae43b8 --- /dev/null +++ b/287/TumorCenter_CD8_block4_x3_y2_patient287_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12318.5, + "Centroid Y µm": 5097.3, + "Num Detections": 23709, + "Num Negative": 22158, + "Num Positive": 1551, + "Positive %": 6.542, + "Num Positive per mm^2": 700.32 + } +} \ No newline at end of file diff --git a/287/TumorCenter_CD8_block4_x4_y2_patient287_1.json b/287/TumorCenter_CD8_block4_x4_y2_patient287_1.json new file mode 100644 index 0000000000000000000000000000000000000000..19df3efda21f002cace0d2210a5d0d3c518bc82c --- /dev/null +++ b/287/TumorCenter_CD8_block4_x4_y2_patient287_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14817.2, + "Centroid Y µm": 5197.2, + "Num Detections": 18858, + "Num Negative": 18289, + "Num Positive": 569, + "Positive %": 3.017, + "Num Positive per mm^2": 255.28 + } +} \ No newline at end of file diff --git a/287/history_text.txt b/287/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..62c17c9f7941ae939c991aca9a1b405ddfd4cfad --- /dev/null +++ b/287/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma G2 in the vallecula and lingual epiglottis area and transition to the arytenoid fold on the left. Extensive lymph node metastasis, mainly on the left, but also on the right. Therefore, the above-mentioned surgery is now indicated. \ No newline at end of file diff --git a/287/icd_codes.txt b/287/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..900ec0e6fa7c0b9bb5f7abc5c4e454ed80ea053f --- /dev/null +++ b/287/icd_codes.txt @@ -0,0 +1 @@ +Karzinom der Vallecula epiglottica[C10.0 ] \ No newline at end of file diff --git a/287/ops_codes.txt b/287/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cf64f37c8c0bec64de6cdf770a14b38a4772172a --- /dev/null +++ b/287/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/287/patient_clinical_data.json b/287/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e7f62f50c439f2ee6798d3c0f2044fbbca036b56 --- /dev/null +++ b/287/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 41, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/287/patient_pathological_data.json b/287/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..30e0e22b23030f5ffdec54aa98223085d99067f4 --- /dev/null +++ b/287/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "287", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 9.0, + "number_of_resected_lymph_nodes": 53, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/287/surgery_description.txt b/287/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ea2e0d68fbd6e3f42c39693d28ae2a69dc997659 --- /dev/null +++ b/287/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Neck dissection, PEG placement, Tracheostomy diff --git a/287/surgery_report.txt b/287/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..62af6bf28a0436bdd478fadc261aad7946f89a6a --- /dev/null +++ b/287/surgery_report.txt @@ -0,0 +1 @@ +First PEG insertion: Insertion of a PEG tube using the thread pull-through method in the typical manner by and . Subsequent laser resection: First insert the small bore tube again and assess the findings. The carcinomulcus can be seen in the area of the left vallecula with transition to the lingual epiglottis up to the cartilage and slightly towards the arytenoid fold. Subsequent insertion of the spreading laryngoscope. Tumor is successively resected. Due to the involvement of the epiglottis up to the cartilage, an approx. 2/3 resection of the epiglottis on the left is performed, the subsequent vallecula is removed with hanging pre-epiglottic fatty tissue. Resection towards the base of the tongue far into the healthy tissue, resection at the transition from the pharyngeal wall to the base of the tongue far into the healthy tissue as well as resection of the upper parts of the aryepiglottic fold. The specimen is then thread-marked. Another marginal sample is taken at the border to the vallecula on the right side of the epiglottis extending to the base of the tongue. Both specimens are sent for frozen section. In the frozen section, the edges of the specimen and the marginal specimen are tumor-free. Thus R0 resection here. Thorough hemostasis is performed. Subsequent repositioning for neck dissection and tracheotomy: start with the tracheotomy. Creation of an epithelialized tracheostoma by and and reintubation of the patient by the anaesthesia colleagues. Now proceed to radical neck dissection on the left side. First, a skin incision is made along the anterior border of the sternocleidomastoid muscle on the left side. Dissection from the cranial to the caudal side, directly encountering multiple large, coarse metastases in region II b to region V on the left side. Cranial exposure of the posterior venter of the digaster muscle. Exposure of the accessorius nerve, which can be preserved. Cranial exposure of the internal jugular vein. Exposure of the hypoglossal nerve, which could also be spared. Exposure of the internal and external carotid artery. Showing the caudal part of the omohyoid muscle, which unfortunately has to be removed. Showing the caudal aspect of the internal jugular vein. The entire lymph node package is dissected out in toto from cranial to caudal, taking the sternocleidomastoid muscle and the internal jugular vein with it, and removed without difficulty. Removal of the internal jugular vein caudally in region V. Creation of a bypass ligature there. Creation of several bypass ligatures to avoid a postoperative chyle fistula on the left side. During the dissection, it was found that the external carotid artery was also affected by the tumor and also had to be treated by means of a bypass and removed. Dry conditions there. Multiple wound irrigation with hydrogen peroxide and Ringer's solution. Dry conditions. No evidence of a chyle fistula on the left. Placement of a 10 Redon drain. Subcutaneous suture. Skin suture. Application of a pressure bandage. Now repositioning of the patient to perform a neck dissection on the right side. Skin incision along the anterior border of the sternocleidomastoid muscle. Expose the digastric muscle cranially, the accessorius nerve and the omohyoid muscle caudally. Exposure of the cervical vascular sheath. Dissection along the cervical vascular sheath from caudal to cranial. Successive removal of the posterior neck preparation while sparing the accessorius nerve, the cervical plexus and the cervical accessorius ramus. Successive removal of the anterior neck preparation. Dry conditions. Wound irrigation using hydrogen peroxide and Ringer's solution. Two-layer wound closure. Application of a pressure dressing and completion of the procedure without complications. Finally, re-insertion of the small irrigation tube and assessment of the resection area. No more bleeding here. During resection, several vessels were treated with clips; these areas are also inconspicuous, with no evidence of bleeding. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Please provide nutrition via the inserted PEG tube for approx. 1 week, then if necessary, dietary support. Dysphagia is to be expected, therefore swallowing rehabilitation should most likely also be necessary. Presentation in the interdisciplinary tumor conference for radiochemotherapy after receiving the histology. \ No newline at end of file diff --git a/288/InvasionFront_CD3_block6_x3_y8_patient288_0.json b/288/InvasionFront_CD3_block6_x3_y8_patient288_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8d1ba21d0b2d97a3ed4963a6d21312254a54fc52 --- /dev/null +++ b/288/InvasionFront_CD3_block6_x3_y8_patient288_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11793.8, + "Centroid Y µm": 20888.9, + "Num Detections": 14351, + "Num Negative": 12769, + "Num Positive": 1582, + "Positive %": 11.02, + "Num Positive per mm^2": 941.84 + } +} \ No newline at end of file diff --git a/288/InvasionFront_CD3_block6_x4_y8_patient288_1.json b/288/InvasionFront_CD3_block6_x4_y8_patient288_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0a6d2ccbdc1f541f29a91564d67c5dca0eb37636 --- /dev/null +++ b/288/InvasionFront_CD3_block6_x4_y8_patient288_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14367.4, + "Centroid Y µm": 21013.9, + "Num Detections": 17534, + "Num Negative": 17359, + "Num Positive": 175, + "Positive %": 0.9981, + "Num Positive per mm^2": 83.03 + } +} \ No newline at end of file diff --git a/288/InvasionFront_CD8_block6_x3_y6_patient288_0.json b/288/InvasionFront_CD8_block6_x3_y6_patient288_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3c593cdb67e0b46bf39d806559b938488ac554e7 --- /dev/null +++ b/288/InvasionFront_CD8_block6_x3_y6_patient288_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12268.5, + "Centroid Y µm": 14917.1, + "Num Detections": 22877, + "Num Negative": 22710, + "Num Positive": 167, + "Positive %": 0.73, + "Num Positive per mm^2": 69.04 + } +} \ No newline at end of file diff --git a/288/InvasionFront_CD8_block6_x4_y6_patient288_1.json b/288/InvasionFront_CD8_block6_x4_y6_patient288_1.json new file mode 100644 index 0000000000000000000000000000000000000000..931d3dcda4cbfecc088fe4f3c59a0983ad19e85a --- /dev/null +++ b/288/InvasionFront_CD8_block6_x4_y6_patient288_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14967.1, + "Centroid Y µm": 15117.0, + "Num Detections": 20980, + "Num Negative": 19924, + "Num Positive": 1056, + "Positive %": 5.033, + "Num Positive per mm^2": 426.07 + } +} \ No newline at end of file diff --git a/288/TumorCenter_CD3_block6_x3_y6_patient288_0.json b/288/TumorCenter_CD3_block6_x3_y6_patient288_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d0bb168bcd3782473ff102cbe29e62fda3b401ce --- /dev/null +++ b/288/TumorCenter_CD3_block6_x3_y6_patient288_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 15216.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/288/TumorCenter_CD3_block6_x4_y6_patient288_1.json b/288/TumorCenter_CD3_block6_x4_y6_patient288_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d91df665142ebb46629ed5d9ba9839dc6a0b6ea4 --- /dev/null +++ b/288/TumorCenter_CD3_block6_x4_y6_patient288_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 15291.9, + "Num Detections": 16833, + "Num Negative": 14716, + "Num Positive": 2117, + "Positive %": 12.58, + "Num Positive per mm^2": 856.95 + } +} \ No newline at end of file diff --git a/288/TumorCenter_CD8_block6_x3_y6_patient288_0.json b/288/TumorCenter_CD8_block6_x3_y6_patient288_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8d68ade0bffecb5b75d6ede1f23f2a176f7a8754 --- /dev/null +++ b/288/TumorCenter_CD8_block6_x3_y6_patient288_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 15691.7, + "Num Detections": 25781, + "Num Negative": 24979, + "Num Positive": 802, + "Positive %": 3.111, + "Num Positive per mm^2": 317.57 + } +} \ No newline at end of file diff --git a/288/TumorCenter_CD8_block6_x4_y6_patient288_1.json b/288/TumorCenter_CD8_block6_x4_y6_patient288_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ce157cf48101d57ab11e71480312ba36886eeb45 --- /dev/null +++ b/288/TumorCenter_CD8_block6_x4_y6_patient288_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 15666.7, + "Num Detections": 27273, + "Num Negative": 26205, + "Num Positive": 1068, + "Positive %": 3.916, + "Num Positive per mm^2": 394.12 + } +} \ No newline at end of file diff --git a/288/history_text.txt b/288/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ec24a817dcf21773672af2a9f51890043f98fadf --- /dev/null +++ b/288/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Persistent swallowing difficulties in the patient. Lupenlaryngoscopic mass in the area of the left hypopharynx. \ No newline at end of file diff --git a/288/icd_codes.txt b/288/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2405a3a2a1f520660c5cade89c8e5753d0d51ba7 --- /dev/null +++ b/288/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] \ No newline at end of file diff --git a/288/ops_codes.txt b/288/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..54603c556a4d200adbe738159a9029cd060461b9 --- /dev/null +++ b/288/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Bronchoskopie und Tracheoskopie durch Inzision und intraoperativ: Tracheoskopie[1-690.1 ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Exzision, lokal[5-292.0 ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Destruktion: Laserkoagulation[5-292.31 ] \ No newline at end of file diff --git a/288/patient_clinical_data.json b/288/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dd245d66260bf6b276b70e67b492f1d025ebe775 --- /dev/null +++ b/288/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 72, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/288/patient_pathological_data.json b/288/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dc9ba9e257f9d9373f928155379b4513989c253d --- /dev/null +++ b/288/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "288", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/288/surgery_description.txt b/288/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..01680623e1b418d81442b518bd90abc45859b695 --- /dev/null +++ b/288/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Laser resection diff --git a/288/surgery_report.txt b/288/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..bb73469ac2e7e6f5757e53e27816d881ccad0f46 --- /dev/null +++ b/288/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Advancement of the 0° optic through the glottic plane into the trachea. Inconspicuous mucosal conditions in the area of the trachea up to the exit of the segmental bronchi. On reflection, inconspicuous mucosal conditions also in the area of the cervical trachea. Intubation of the patient. Inspection of the subglottis, glottis and supraglottis. Inconspicuous mucosal conditions on all sides. Inspection of the hypopharynx and the postcricoid region. The right hypopharynx and the postcricoid region show unremarkable mucosal conditions. In the region of the left hypopharynx, at the level of the entrance to the piriform sinus, there is a coarse mass which is centrally exulcerated and which is easily displaceable against the base. Beyond this, the mucosa is unremarkable. Inspection of the oropharynx and after pulling up the soft palate of the nasopharynx. Inconspicuous mucosal conditions here. No abnormalities in the oral cavity either. Advance the flexible endoscope into the stomach. Careful reflection back. Inconspicuous mucosal conditions in the area of the oesophagus. Adjustment of the findings described above with the small bore tube. From the aspect, the change appears to be benign. Now use the laser to cut around this process and remove it just inside the healthy area, as far as this can be clinically assessed. Careful hemostasis. Insertion of a gastric tube. Completion of the procedure. Final consultation with the anesthetist. Further procedure depending on the histology. The laser resection was performed using a microscope and an intensity of 1.5 - 3 watts. \ No newline at end of file diff --git a/289/InvasionFront_CD3_block13_x5_y10_patient289_0.json b/289/InvasionFront_CD3_block13_x5_y10_patient289_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c7b1eccf8d9d843146a1f7795c94563c44f4e98d --- /dev/null +++ b/289/InvasionFront_CD3_block13_x5_y10_patient289_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 24062.3, + "Num Detections": 21974, + "Num Negative": 20422, + "Num Positive": 1552, + "Positive %": 7.063, + "Num Positive per mm^2": 643.26 + } +} \ No newline at end of file diff --git a/289/InvasionFront_CD3_block13_x6_y10_patient289_1.json b/289/InvasionFront_CD3_block13_x6_y10_patient289_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7598531a87b7b79ac195796f5ea374750c4ae916 --- /dev/null +++ b/289/InvasionFront_CD3_block13_x6_y10_patient289_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 24012.3, + "Num Detections": 23442, + "Num Negative": 22304, + "Num Positive": 1138, + "Positive %": 4.855, + "Num Positive per mm^2": 471.4 + } +} \ No newline at end of file diff --git a/289/InvasionFront_CD8_block13_x5_y10_patient289_0.json b/289/InvasionFront_CD8_block13_x5_y10_patient289_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5d36a14f5ce2c19cab04a39065019d7667193323 --- /dev/null +++ b/289/InvasionFront_CD8_block13_x5_y10_patient289_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16766.1, + "Centroid Y µm": 26186.1, + "Num Detections": 20917, + "Num Negative": 19967, + "Num Positive": 950, + "Positive %": 4.542, + "Num Positive per mm^2": 390.29 + } +} \ No newline at end of file diff --git a/289/InvasionFront_CD8_block13_x6_y10_patient289_1.json b/289/InvasionFront_CD8_block13_x6_y10_patient289_1.json new file mode 100644 index 0000000000000000000000000000000000000000..082ddcce8181ccdd97bb1e2b9eb62afeccea5406 --- /dev/null +++ b/289/InvasionFront_CD8_block13_x6_y10_patient289_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19264.8, + "Centroid Y µm": 26336.1, + "Num Detections": 16416, + "Num Negative": 15496, + "Num Positive": 920, + "Positive %": 5.604, + "Num Positive per mm^2": 416.1 + } +} \ No newline at end of file diff --git a/289/TumorCenter_CD3_block13_x5_y10_patient289_0.json b/289/TumorCenter_CD3_block13_x5_y10_patient289_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fc3be3de7e6685df2b29198fd499effc98b21fbb --- /dev/null +++ b/289/TumorCenter_CD3_block13_x5_y10_patient289_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16166.4, + "Centroid Y µm": 31733.2, + "Num Detections": 19290, + "Num Negative": 18138, + "Num Positive": 1152, + "Positive %": 5.972, + "Num Positive per mm^2": 502.51 + } +} \ No newline at end of file diff --git a/289/TumorCenter_CD3_block13_x6_y10_patient289_1.json b/289/TumorCenter_CD3_block13_x6_y10_patient289_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3f676f993bc5eb4b07286621311f8a62823fdd9 --- /dev/null +++ b/289/TumorCenter_CD3_block13_x6_y10_patient289_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 31908.1, + "Num Detections": 20697, + "Num Negative": 18597, + "Num Positive": 2100, + "Positive %": 10.15, + "Num Positive per mm^2": 858.7 + } +} \ No newline at end of file diff --git a/289/TumorCenter_CD8_block13_x5_y10_patient289_0.json b/289/TumorCenter_CD8_block13_x5_y10_patient289_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cbc646d146035ffcc875b40eb403b1eacaf7478e --- /dev/null +++ b/289/TumorCenter_CD8_block13_x5_y10_patient289_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 24137.2, + "Num Detections": 18961, + "Num Negative": 18209, + "Num Positive": 752, + "Positive %": 3.966, + "Num Positive per mm^2": 339.95 + } +} \ No newline at end of file diff --git a/289/TumorCenter_CD8_block13_x6_y10_patient289_1.json b/289/TumorCenter_CD8_block13_x6_y10_patient289_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bdca113c098d2274b0c55e1020e794cd2aa05a4c --- /dev/null +++ b/289/TumorCenter_CD8_block13_x6_y10_patient289_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20489.2, + "Centroid Y µm": 23737.4, + "Num Detections": 23273, + "Num Negative": 22459, + "Num Positive": 814, + "Positive %": 3.498, + "Num Positive per mm^2": 334.9 + } +} \ No newline at end of file diff --git a/289/history_text.txt b/289/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/289/icd_codes.txt b/289/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/289/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/289/ops_codes.txt b/289/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6eb5b50c9d63b128f4ae2061a8975ec3c2b6925f --- /dev/null +++ b/289/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 6 Regionen[5-403.05 B] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 B] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme freier Radialis-Lappen[5-858.23 L] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] Großflächige Spalthautdeckung am Unterarm[5-902.48 L] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/289/patient_clinical_data.json b/289/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dbe5e713184d9cee3ed421575c5106b67edf3421 --- /dev/null +++ b/289/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/289/patient_pathological_data.json b/289/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8f2c336bbdb91ca0e34bbe760df4e36c581c5185 --- /dev/null +++ b/289/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "289", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 44, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/289/surgery_description.txt b/289/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..984ba268150fe34793ffac8d082f40c4091b7889 --- /dev/null +++ b/289/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheotomy, PEG placement, Defect coverage diff --git a/289/surgery_report.txt b/289/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e27074178d2934d7b6878c63b08faac5957ebbcf --- /dev/null +++ b/289/surgery_report.txt @@ -0,0 +1 @@ +Transferring the patient to the operating theater and positioning the patient. Introductory consultation with anesthesia and team time-out. Start tracheotomy after transoral intubation. Sterile abjoration and draping after injection of suprarenin with lidocaine, horizontal incision, dissection through the subcutaneous fatty tissue and dissection through the prelaryngeal muscles. Identification of the thyroid gland and transection of the thyroid gland in the middle with careful and successive coagulation. Exposure of the trachea and blunt dissection using a pedicle. Now enter between the 2nd and 3rd tracheal cartilage, create a visor tracheotomy. Suturing in the usual manner. Now place the PEG system, this is easily achieved with good diaphanoscopy using the thread pull-through method. Now sterile abjodation and covering and start with the transoral tumor resection. The tumor is resected at a distance of 1 cm, the extent of the tumor affects the floor of the mouth on the right side, the alveolar ridge on the right side (however, the tumor can be easily pushed away from this using Freer), there is no evidence of bone erosion. The glossotonsillar groove on the right side extends almost into the left glossotonsillar groove. The tumor extends caudally into the vallecula. The right lingual artery is ligated. On the left side, a pulsating vessel is still palpable in the depth, even after resection, 'so that the left side of the tongue should still be supplied. Due to the size of the tumor and a palpable cone extending both laterally and caudally, now combined transoral, transcervical resection. Skin incision and dissection through the fatty tissue, dissection through the platysma. Now subplatysmal dissection and finding the anterior margin of the sternocleidomastoid muscle. Expose the anterior border of the sternocleidomastoid muscle and find the omohyoid muscle. Cranial dissection. Exposure of the accessorius nerve and the posterior vein of the digastric muscle. It can be seen that the tumor extends into the submandibular lobe and has a medial extension to the pharyngeal tube. Pull through technique of the tumor. Submandibulectomy on the right. Further successive dissection of the tumor at a distance of approx. 1 cm from the surrounding tissue. The tumor can be completely removed. After suture marking, the tumor is sent for frozen section. The tumor is resected R0 on the specimen. The pharyngeal flap is opened and sutured using single button sutures. Now complete the neck dissection on the right side. Exposure of the neck-vascular sheath and identification and protection of the vagus nerve. Successive removal of the lateral and medial neck preparation. Exposure of the hypoglossal nerve and protection of this. Dissection of the facial artery and removal of this for anastomosis. Neck dissection on the left side. Skin incision and dissection through the subcutaneous fatty tissue, dissection through the platysma. Now subplatysmal dissection and discovery of the anterior border of the sternocleidomastoid muscle. Expose the anterior border of the sternocleidomastoid muscle and find the omohyoid muscle. Cranial dissection. Now expose the submandibular gland and pull the submandibular gland cranially with the Langenbeck to protect the marginal ramus. Locate the posterior venter of the digastric muscle. Blunt dissection using a finger and clamp posteriorly in level IIb and finding the digastric muscle here too. Finding and preserving the accessorius nerve. Free preparation of the digastric muscle and knocking down the neck preparation. Now dissect along the cervical vascular sheath in a cranial direction. Here both the facial and external jugular veins are ligated and the common and external carotid arteries are exposed. Identification of the hypoglossal nerve and preservation of this. Successive removal of the lateral and medial neck preparation with preservation of the ansa and brachial plexus. The vagus nerve can also be identified and spared. There is no evidence of a chyle fistula. Now expose the ramus marginalis, the facial nerve and dissect anteriorly. Expose the submandibular gland and remove it. Ligation of the facial artery and the duct. Protection of the lingual nerve on the left side after submandibulectomy. Now successive removal of Level Ia and b so that Level Ia and b, Level IIa and b, III, IV and V have been removed in total. If there is no indication of increased bleeding, irrigation of the neck and insertion of a Redondra ring. Two-layer wound closure. Elevation of the radialis graft by and : Palpatory identification of the distal radial artery. Marking of the flap borders (14 x 6 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Covering of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Now pulling the flap through enorally and suturing the flap to the defect in the usual way with Vicryl 4-0 single-button sutures. Now inspect the vessels. It can be seen that the facial artery on the right side is thrombosed even after cutting it back. Ligation of this and free preparation of the superior thyroid artery. Connection of the radial artery to the right superior thyroid artery in the usual manner. Suturing of 2 veins end-to-side to the internal jugular vein. Positioning of the pedicle and suturing using Vicryl sutures. Good aspect. Insertion of a Redon drainage and a flap as well as two-layer wound closure. Final consultation with the anesthesiologist, reintubation and completion of the operation. \ No newline at end of file diff --git a/290/InvasionFront_CD3_block16_x1_y6_patient290_0.json b/290/InvasionFront_CD3_block16_x1_y6_patient290_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2f75be5f3a36128a1ca2c6dc64b1e2fe0dacff91 --- /dev/null +++ b/290/InvasionFront_CD3_block16_x1_y6_patient290_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4454.5, + "Centroid Y µm": 19438.3, + "Num Detections": 18873, + "Num Negative": 16892, + "Num Positive": 1981, + "Positive %": 10.5, + "Num Positive per mm^2": 808.58 + } +} \ No newline at end of file diff --git a/290/InvasionFront_CD3_block16_x2_y6_patient290_1.json b/290/InvasionFront_CD3_block16_x2_y6_patient290_1.json new file mode 100644 index 0000000000000000000000000000000000000000..08b45139b41e53afda164fb690f8d9a0dd09a748 --- /dev/null +++ b/290/InvasionFront_CD3_block16_x2_y6_patient290_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6885.4, + "Centroid Y µm": 19501.7, + "Num Detections": 21561, + "Num Negative": 19646, + "Num Positive": 1915, + "Positive %": 8.882, + "Num Positive per mm^2": 749.58 + } +} \ No newline at end of file diff --git a/290/InvasionFront_CD8_block16_x1_y6_patient290_0.json b/290/InvasionFront_CD8_block16_x1_y6_patient290_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4bf6a3f4fd2238abd43b8d16eb3408dfed0af9cb --- /dev/null +++ b/290/InvasionFront_CD8_block16_x1_y6_patient290_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3483.5, + "Centroid Y µm": 14523.8, + "Num Detections": 20236, + "Num Negative": 15057, + "Num Positive": 5179, + "Positive %": 25.59, + "Num Positive per mm^2": 2075.9 + } +} \ No newline at end of file diff --git a/290/InvasionFront_CD8_block16_x2_y6_patient290_1.json b/290/InvasionFront_CD8_block16_x2_y6_patient290_1.json new file mode 100644 index 0000000000000000000000000000000000000000..de3a826de0dec71115e915ab4477f3c2ff5ab3b6 --- /dev/null +++ b/290/InvasionFront_CD8_block16_x2_y6_patient290_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5997.9, + "Centroid Y µm": 14655.1, + "Num Detections": 21541, + "Num Negative": 19348, + "Num Positive": 2193, + "Positive %": 10.18, + "Num Positive per mm^2": 854.89 + } +} \ No newline at end of file diff --git a/290/TumorCenter_CD3_block16_x1_y6_patient290_0.json b/290/TumorCenter_CD3_block16_x1_y6_patient290_0.json new file mode 100644 index 0000000000000000000000000000000000000000..db3f633d892b29ef287cf08184c3d74d631bcd88 --- /dev/null +++ b/290/TumorCenter_CD3_block16_x1_y6_patient290_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4322.7, + "Centroid Y µm": 15042.0, + "Num Detections": 19936, + "Num Negative": 15558, + "Num Positive": 4378, + "Positive %": 21.96, + "Num Positive per mm^2": 1726.7 + } +} \ No newline at end of file diff --git a/290/TumorCenter_CD3_block16_x2_y6_patient290_1.json b/290/TumorCenter_CD3_block16_x2_y6_patient290_1.json new file mode 100644 index 0000000000000000000000000000000000000000..12900480d34e33f6cf64fa1329ce661cdfeebd8d --- /dev/null +++ b/290/TumorCenter_CD3_block16_x2_y6_patient290_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 15167.0, + "Num Detections": 21206, + "Num Negative": 18100, + "Num Positive": 3106, + "Positive %": 14.65, + "Num Positive per mm^2": 1199.0 + } +} \ No newline at end of file diff --git a/290/TumorCenter_CD8_block16_x1_y6_patient290_0.json b/290/TumorCenter_CD8_block16_x1_y6_patient290_0.json new file mode 100644 index 0000000000000000000000000000000000000000..39dcab46265245b9d060fed796a842e8d2006cdb --- /dev/null +++ b/290/TumorCenter_CD8_block16_x1_y6_patient290_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 15491.8, + "Num Detections": 20184, + "Num Negative": 16637, + "Num Positive": 3547, + "Positive %": 17.57, + "Num Positive per mm^2": 1439.2 + } +} \ No newline at end of file diff --git a/290/TumorCenter_CD8_block16_x2_y6_patient290_1.json b/290/TumorCenter_CD8_block16_x2_y6_patient290_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e08811f3193b58ae7233e6f84c92090c8c3a3674 --- /dev/null +++ b/290/TumorCenter_CD8_block16_x2_y6_patient290_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5971.8, + "Centroid Y µm": 15566.8, + "Num Detections": 20913, + "Num Negative": 18415, + "Num Positive": 2498, + "Positive %": 11.94, + "Num Positive per mm^2": 982.81 + } +} \ No newline at end of file diff --git a/290/history_text.txt b/290/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/290/icd_codes.txt b/290/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/290/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/290/ops_codes.txt b/290/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cf84c786f4fc96e63db25428ada7b015a03762ac --- /dev/null +++ b/290/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] PEG[5-431.2 ] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 L] \ No newline at end of file diff --git a/290/patient_clinical_data.json b/290/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2e892f911f35b0114c8398d1237aa15767aa4df2 --- /dev/null +++ b/290/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 58, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy + brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/290/patient_pathological_data.json b/290/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1b78b02d7a281c27cc05d6a9aca3087a1d7be333 --- /dev/null +++ b/290/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "290", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 58, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/290/surgery_description.txt b/290/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d260b0f47d448d0805c3cf67ec38bf8795edd0d1 --- /dev/null +++ b/290/surgery_description.txt @@ -0,0 +1 @@ +Tumor excision, Bilateral neck dissection, PEG placement diff --git a/290/surgery_report.txt b/290/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..719861996315860d1f018ac566335886454b6838 --- /dev/null +++ b/290/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia, head positioning and entering with the small water tube. Re-inspection of the tumor region. The tumor extends in the posterior third of the edge of the tongue, extends to the base of the tongue, the glossotonsillar groove and the alveolar ridge, but is displaceable in relation to these. Now insertion of the retractors. Place a retaining thread and pull out the tongue. Establish the resection margins with a sufficient safety margin around the tumor. Now successive dissection of the tumor, taking the right palatine tonsil with it. Careful protection of the right posterior palatal arch, the lingual nerve, the lingual fibers of the hypoglossal nerve and the Wharton's duct. Excision of the tumor with sufficient safety margin in toto. The specimen is thread-marked for frozen section diagnostics. Careful hemostasis using bipolar coagulation. In the frozen section, the tumor is found to be R0 resected, but the specimen shows a carcinoma in situ that is probably not connected to the tumor and reaches the edge of the palatal arch. Before resecting the tumor, the patient was first examined with an esophagogastroscope. Pre-viewing to the stomach and placement of the PEG tube using the thread pull-through method in the typical manner, after positive diaphanoscopy. Now turn first to neck dissection on the right. After skin disinfection, infiltration anesthesia with Ultracaine with added adrenaline. Skin incision on the anterior border of the sternocleidomastoid muscle. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the digastric muscle. Exposure of the cervical vascular sheath with jugular vein, carotid artery and vagus nerve. Sparing of the structures. Exposure of the accessorius nerve and protection of the same. Now successive dissection of the lateral neck preparation while carefully protecting the plexus branches. Subsequent dissection of the remaining soft tissue below the plexus from level V. Careful hemostasis with bipolar coagulation. Several large nodes are seen in level II, these are excised in toto, the accessorius nerve can be spared here. Resection of the medial neck preparation while sparing the hypoglossal nerve. Now turn to the left neck dissection. Here too, infiltration anesthesia with Ultracaine with the addition of adrenaline after skin disinfection. Skin incision on the anterior border of the sternocleidomastoid muscle. Exposure and dissection of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and the digastric muscle. Exposure of the accessorius nerve and protection of the same. Dissection of the cervical vascular sheath with jugular vein, carotid artery and vagus nerve. Now successive dissection of the lateral neck preparation while sparing the plexus branches. Careful hemostasis using bipolar coagulation. Now, post-dissection in the area of the medial neck preparation and removal of the remaining soft tissue while carefully protecting the structures mentioned. Now irrigation on both sides using hydrogen and Ringer's solution. Insertion of a Redon drain. Subcutaneous suture, skin suture. Now insert the mouth retractor again and turn to the primary tumor region. Post-resection in the area of the right uvular margin and the palatal arch. The specimen is sent for final histology. Removal of a marginal sample, which is again sent for frozen section diagnostics. Once again careful hemostasis using bipolar coagulation. In the frozen section, moderate dysplasia is still seen in the marginal sample, no evidence of carcinoma or carcinoma in situ. The operation was therefore terminated after further careful hemostasis. Conclusion: Enormal resection and neck dissection on both sides of a cT2 tongue margin carcinoma on the right. In the frozen section, in addition to the carcinoma, a carcinoma in situ in the area of the palatal arch, therefore, due to the clinical suspicion of field cancerization, adjuvant radiotherapy is indicated. Please present postoperatively at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/291/InvasionFront_CD3_block18_x3_y4_patient291_0.json b/291/InvasionFront_CD3_block18_x3_y4_patient291_0.json new file mode 100644 index 0000000000000000000000000000000000000000..98e7ba612c771228b760216d1b5bfc739524153a --- /dev/null +++ b/291/InvasionFront_CD3_block18_x3_y4_patient291_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11518.9, + "Centroid Y µm": 14642.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/291/InvasionFront_CD3_block18_x4_y4_patient291_1.json b/291/InvasionFront_CD3_block18_x4_y4_patient291_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c699efe8987c6d7c5c7333c640c47ffe33efaffb --- /dev/null +++ b/291/InvasionFront_CD3_block18_x4_y4_patient291_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14292.4, + "Centroid Y µm": 14842.1, + "Num Detections": 10366, + "Num Negative": 9098, + "Num Positive": 1268, + "Positive %": 12.23, + "Num Positive per mm^2": 985.95 + } +} \ No newline at end of file diff --git a/291/InvasionFront_CD8_block18_x3_y4_patient291_0.json b/291/InvasionFront_CD8_block18_x3_y4_patient291_0.json new file mode 100644 index 0000000000000000000000000000000000000000..70a5e38ace0803bbb1f440de18226f9285949e81 --- /dev/null +++ b/291/InvasionFront_CD8_block18_x3_y4_patient291_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11419.0, + "Centroid Y µm": 17815.6, + "Num Detections": 16903, + "Num Negative": 15237, + "Num Positive": 1666, + "Positive %": 9.856, + "Num Positive per mm^2": 837.47 + } +} \ No newline at end of file diff --git a/291/InvasionFront_CD8_block18_x4_y4_patient291_1.json b/291/InvasionFront_CD8_block18_x4_y4_patient291_1.json new file mode 100644 index 0000000000000000000000000000000000000000..359ff491b64884c148e2d2d2c448a85dd222d27f --- /dev/null +++ b/291/InvasionFront_CD8_block18_x4_y4_patient291_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13970.2, + "Centroid Y µm": 17915.5, + "Num Detections": 17242, + "Num Negative": 16280, + "Num Positive": 962, + "Positive %": 5.579, + "Num Positive per mm^2": 488.53 + } +} \ No newline at end of file diff --git a/291/TumorCenter_CD3_block18_x3_y4_patient291_0.json b/291/TumorCenter_CD3_block18_x3_y4_patient291_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a283869f9ffaa2cb5ac04eddf75e05e868a55cd2 --- /dev/null +++ b/291/TumorCenter_CD3_block18_x3_y4_patient291_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10774.4, + "Centroid Y µm": 9759.8, + "Num Detections": 10598, + "Num Negative": 10061, + "Num Positive": 537, + "Positive %": 5.067, + "Num Positive per mm^2": 384.94 + } +} \ No newline at end of file diff --git a/291/TumorCenter_CD3_block18_x4_y4_patient291_1.json b/291/TumorCenter_CD3_block18_x4_y4_patient291_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5d79c3e722b804546f2e4ea5e48b0a337413d907 --- /dev/null +++ b/291/TumorCenter_CD3_block18_x4_y4_patient291_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13287.9, + "Centroid Y µm": 9731.3, + "Num Detections": 14153, + "Num Negative": 13567, + "Num Positive": 586, + "Positive %": 4.14, + "Num Positive per mm^2": 298.1 + } +} \ No newline at end of file diff --git a/291/TumorCenter_CD8_block18_x3_y4_patient291_0.json b/291/TumorCenter_CD8_block18_x3_y4_patient291_0.json new file mode 100644 index 0000000000000000000000000000000000000000..310fddc7c20940b05be61d8d4fd1fe1cf5bf7160 --- /dev/null +++ b/291/TumorCenter_CD8_block18_x3_y4_patient291_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 10419.5, + "Num Detections": 10565, + "Num Negative": 9721, + "Num Positive": 844, + "Positive %": 7.989, + "Num Positive per mm^2": 597.88 + } +} \ No newline at end of file diff --git a/291/TumorCenter_CD8_block18_x4_y4_patient291_1.json b/291/TumorCenter_CD8_block18_x4_y4_patient291_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1fcae0f3671abb4eb2584bb49fd2092fdace280c --- /dev/null +++ b/291/TumorCenter_CD8_block18_x4_y4_patient291_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13317.9, + "Centroid Y µm": 10469.5, + "Num Detections": 13955, + "Num Negative": 13168, + "Num Positive": 787, + "Positive %": 5.64, + "Num Positive per mm^2": 397.06 + } +} \ No newline at end of file diff --git a/291/history_text.txt b/291/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/291/icd_codes.txt b/291/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..052a14170998e2e80dca93c824b7e71944b0428c --- /dev/null +++ b/291/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 R] \ No newline at end of file diff --git a/291/ops_codes.txt b/291/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7147126b6d18e6dc655b3d36ff4203c6b544aff3 --- /dev/null +++ b/291/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie ohne Rekonstruktion[5-303.00 ] Permanente Tracheotomie[5-312.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] \ No newline at end of file diff --git a/291/patient_clinical_data.json b/291/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7af70c4abce7b5e9f55dc6d6ead47646d0bfec85 --- /dev/null +++ b/291/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 310, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/291/patient_pathological_data.json b/291/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..309f7a06d7cf786eafcec8071bdf6577367489af --- /dev/null +++ b/291/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "291", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 44, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.7", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/291/surgery_description.txt b/291/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f971d993e4c7dfe2670aa543472d28069fae2035 --- /dev/null +++ b/291/surgery_description.txt @@ -0,0 +1 @@ +Total laryngectomy with primary voice rehabilitation diff --git a/291/surgery_report.txt b/291/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..dc92cfd1f8c97722cc7b547723f38a36943077e1 --- /dev/null +++ b/291/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. After appropriate preparation, the gastric tube is first inserted through the left nasal cavity, the correct position of which is then checked by auscultation. Skin disinfection. Infiltration with local anesthetic containing adrenaline in the area of the subsequent skin incision. Sterile washing and draping. Marking of the apron flap incision with the tracheostoma in place. Dissection of the apron flap and cranial fixation in the usual manner. Then perform the neck dissection, initially on the left side. After skeletonization of the sternocleidomastoid muscle, the auricularis magnus nerve is exposed and spared until the end. Displacement and, at the end of the operation, re-embedding of the auricularis magnus nerve in the sense of neurolysis. The same is done with the accessorius nerve. Displacement and re-embedding of the accessorius nerve at the end of the operation in the sense of a neurolysis. Skeletonization of the digastric muscle with exposure and protection of the hypoglossal nerve on the left side. Displacement and re-embedding of the hypoglossal nerve at the end of the operation. Opening of the cervical vascular nerve sheath and skeletonization of the internal jugular vein after identification of the vagus nerve. Regions II to V are then successively resected while preserving all non-lymphatic structures. Exposure of the lateral horn of the hyoid bone. Removal of the supralaryngeal vascular nerve bundle. Separation of the left larynx caudal to the hyoid bone. Exposure of the left lobe of the thyroid gland and lateral dissection. Separation of the straight neck muscles just above the clavicle. Undercutting of the isthmus, clamping, and removal and ligation on both sides. Separation of the constrictor pharyngis muscle from the thyroid cartilage and release of the piriform sinus on the left side. Transition to the opposite side. Similar procedure here. Here, too, there is no clinical evidence of a cervical lymph node metastasis. After complete mobilization of the larynx, the tracheostoma is first created. The 2nd tracheal clasp is incised in an H-shape and the caudal mucocutaneous anastomosis is created first. The lingual side of the epiglottis is then exposed through the pre-epiglottic fat body. Then open the pharynx and develop the larynx caudally along the epiglottis and the aryepiglottic folds. The tumor appears to be purely endolaryngeal. Both incisions are then connected caudally on the posterior surface of the cricoid cartilage. Dissection caudally up to the 1st tracheal clasp. The entire laryngeal preparation is then removed together with the 1st tracheal clasp. Circular marginal incisions are taken from the pharyngeal defect as well as from the specimen itself at the right sublaryngeal margin. All marginal incisions proved to be free of tumor and dysplasia. Myotomy of the constrictor pharyngis muscle. Insertion of a Provox voice prosthesis at the upper edge of the tracheostoma in the usual manner. Then suture of the pharyngeal defect with a continuous inverting Conley suture. The second suture layer is performed using single button sutures. Insertion of a Redon suction drain on both sides. Completion of the mucocutaneous anastomosis of the tracheostoma. Two-layer wound closure on both sides. Sterile wound dressing. Application of a pressure dressing. Final consultation with the anesthetist. Conclusion: Total laryngectomy with primary voice rehabilitation by insertion of a Provox voice prosthesis and myotomy of the constrictor pharyngis muscle, selective neck dissection of regions II to V on both sides and insertion of a nasogastric tube. \ No newline at end of file diff --git a/292/InvasionFront_CD8_block5_x1_y12_patient292_0.json b/292/InvasionFront_CD8_block5_x1_y12_patient292_0.json new file mode 100644 index 0000000000000000000000000000000000000000..785dd377520d444ab584f223585a6cdb850b19d6 --- /dev/null +++ b/292/InvasionFront_CD8_block5_x1_y12_patient292_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3922.9, + "Centroid Y µm": 30009.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/292/InvasionFront_CD8_block5_x2_y12_patient292_1.json b/292/InvasionFront_CD8_block5_x2_y12_patient292_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7c08437f4ffc94951f2757e1586a6c8eb5352e12 --- /dev/null +++ b/292/InvasionFront_CD8_block5_x2_y12_patient292_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 29909.2, + "Num Detections": 15636, + "Num Negative": 15189, + "Num Positive": 447, + "Positive %": 2.859, + "Num Positive per mm^2": 221.43 + } +} \ No newline at end of file diff --git a/292/TumorCenter_CD3_block5_x1_y12_patient292_0.json b/292/TumorCenter_CD3_block5_x1_y12_patient292_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4863b5097cebf668c150889695eeef60d6aa49f4 --- /dev/null +++ b/292/TumorCenter_CD3_block5_x1_y12_patient292_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3598.1, + "Centroid Y µm": 29109.6, + "Num Detections": 22863, + "Num Negative": 20895, + "Num Positive": 1968, + "Positive %": 8.608, + "Num Positive per mm^2": 765.36 + } +} \ No newline at end of file diff --git a/292/TumorCenter_CD3_block5_x2_y12_patient292_1.json b/292/TumorCenter_CD3_block5_x2_y12_patient292_1.json new file mode 100644 index 0000000000000000000000000000000000000000..84ad03f26142ef4d270b347a2b58387d9c867f94 --- /dev/null +++ b/292/TumorCenter_CD3_block5_x2_y12_patient292_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 29259.5, + "Num Detections": 19741, + "Num Negative": 17531, + "Num Positive": 2210, + "Positive %": 11.19, + "Num Positive per mm^2": 938.1 + } +} \ No newline at end of file diff --git a/292/TumorCenter_CD8_block5_x1_y12_patient292_0.json b/292/TumorCenter_CD8_block5_x1_y12_patient292_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d7002d52df29e5f6d56e658858d574ba776e382b --- /dev/null +++ b/292/TumorCenter_CD8_block5_x1_y12_patient292_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 30234.0, + "Num Detections": 19334, + "Num Negative": 18191, + "Num Positive": 1143, + "Positive %": 5.912, + "Num Positive per mm^2": 486.57 + } +} \ No newline at end of file diff --git a/292/TumorCenter_CD8_block5_x2_y12_patient292_1.json b/292/TumorCenter_CD8_block5_x2_y12_patient292_1.json new file mode 100644 index 0000000000000000000000000000000000000000..71fede1627a84847507773f09fab38595d832c4d --- /dev/null +++ b/292/TumorCenter_CD8_block5_x2_y12_patient292_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6171.7, + "Centroid Y µm": 30159.0, + "Num Detections": 16391, + "Num Negative": 14017, + "Num Positive": 2374, + "Positive %": 14.48, + "Num Positive per mm^2": 1103.6 + } +} \ No newline at end of file diff --git a/292/history_text.txt b/292/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/292/icd_codes.txt b/292/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..51d1f5ceb098d727ccb19c35b685a04e05f3d1ce --- /dev/null +++ b/292/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/292/ops_codes.txt b/292/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..28632054a54ec46ce0cc7a84566ffee34220d25a --- /dev/null +++ b/292/ops_codes.txt @@ -0,0 +1 @@ +Sonstige radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.x4 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Temporäre Tracheotomie[5-311.0 ] PEG durch Fadendurchzugsmethode[5-431.20 ] Spalthaut bei Verbrennungen und Verätzungen Entnahmestelle Oberschenkel und Knie[5-924.0e R] Entnahme von Spalthaut des Unterarmes[5-901.08 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Zungenteilresektion onA[5-251.y ] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 L] \ No newline at end of file diff --git a/292/patient_clinical_data.json b/292/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5ad717533e40f4debb1f48c677fd3244bef45017 --- /dev/null +++ b/292/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 79, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/292/patient_pathological_data.json b/292/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3f5217253ef2c8ff7b8372ddd7518dd49eb997d7 --- /dev/null +++ b/292/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "292", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 24.0 +} \ No newline at end of file diff --git a/292/surgery_description.txt b/292/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf085921446279f802d08a1413a24436a24eaebc --- /dev/null +++ b/292/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Free flap (Radial) diff --git a/292/surgery_report.txt b/292/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9db849796feb4517d4835069c5651c6508ac14fc --- /dev/null +++ b/292/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, the PEG tube is first inserted: PEG insertion using the thread pull-through method in the usual manner. With good diaphanoscopy, this could be done without any problems. Then, after sterile washing and draping and removal of the arm, the tracheostomy is started. After a transverse skin incision, the remaining prelaryngeal musculature is pushed apart and the trachea is exposed on the pretracheal lamina. The remaining rudimentary isthmus is then clamped, cut and stitched. The tracheostomy is then performed between the 2nd and 3rd tracheal clasp and the patient is reintubated without difficulty after completion of the mucocutaneous anastomosis. The operation then begins by opening the neck on the left side. The subcutaneous tissue and the platysma are cut sharply after a skin incision. Identification of the front edge of the sternocleidomastoid muscle and exposure of the vascular nerve sheath. The regions I to V are then evacuated, preserving all non-lymphatic structures. The superior thyroid artery, which is very small in caliber, is then skeletonized. The lingual artery and the facial artery are then dissected up to the mandible, separated and cut caudally for subsequent anastomosis. After identification of the ramus marginalis mandibulae, the periosteum of the mandible is sharply incised on the underside of the mandible and dissected enorally with the rasparatorium. The submandibular gland remains on the later resection specimen and is only exposed laterally, dorsally and ventrally. Subsequently, transition to transoral tumor resection. This is significantly limited due to the restricted mouth opening. The tumor extends to the left into the anterior floor of the mouth and also occupies the lateral third of the tongue. Palpatorily, it extends further back towards the base of the tongue almost to the midline. Therefore, start resection at the front and in the area of the tongue body with sufficient palpatory safety distance using the ultrasonic knife. The periosteum of the mandible on the side is sharply incised about 3 mm below the row of teeth and pushed off with the rasparator. There is no macroscopic evidence of tumor infiltration. In this way, the tumor is gradually developed from the front. The resection extends almost beyond the midline in the area of the base of the tongue. Subsequent transition to the transcervical area. Here, the pharynx is opened cranial to the hyoid bone so that a direct view of the tumor and the base of the tongue can also be obtained from here. After appropriate mobilization of the tumour transorally, the tumour can finally be mobilized cervically and finally removed with an appropriate muscle cuff. It is particularly difficult to remove a tumor extension that extends far caudally and medially, but which is ultimately included in the specimen. After removal of the specimen, it is marked accordingly. Removal of marginal sections in the area of the base of the tongue and the body of the tongue from the specimen itself and from all marginal areas. These are all found to be tumor-free. The frozen section taken in pathology from the lateral gingival area is also tumor-free. Basally, the frozen section pathological examination shows that the tumor is in toto, but with a distance of about 0.2 mm. Therefore, an appropriate resection is performed at this point basally without macroscopic evidence of further tumor parts. Ultimately, an R0 resection can be assumed. Subsequently, a 6 x 10 cm radialis graft is removed from the left forearm. Marking of the flap as well as the vessels and landmarks. Skin incision and dissection through the subcutaneous fatty tissue. Finding the cephalic vein and radial dissection of the cephalic vein. Now locate the confluence. Locate the bellies of the carpi radialis and brachioradialis muscles and successively dissect the muscle bellies until the pedicle is found. Undermination of the pedicle and tracing of the two superficial veins to above the crook of the elbow and snaring with a ligature. Now also dissect the radial artery up to the junction of the ulnar artery and ligate with one side. The flap is first incised on the ulnar side and dissected subfascially. Here the ulnar artery is very superficial, especially in the distal area it is exposed over a distance of 2 cm after detachment of the flap, but it can be completely spared. Smaller detachments are clipped. Now subfascial dissection of the ulnar side up to the flexor carpi radialis tendon. Now continue dissection from the radial side along the cephalic vein and also here clip various branches up to the distal side. Carefully elevate the cephalic vein with the overlying subcutaneous tissue as well as the flap and find the superficial ramus of the radial nerve and preserve it. A small branch extending into the flap is coagulated and cut. Suture the subcutaneous connective tissue to the radial and ulnar flap. The stalk, which is already exposed proximally, is now successively dissected and exposed distally. Locate the radial artery and snare it with a lateral suture. Lift the myofascial flap from the base so that it is only pedicled at the vessels. Now ligate the two veins and clip smaller venous branches and ligate the arteries laterally. Removal of the flap. Smaller bleedings are still pedicled bipolar. Lifting the split skin of the right lower leg and treating it. Sterile wound dressing. Suturing of the split skin in the usual manner and two-layer wound closure. Performing pie crusts. Application of octeniline and a plaster cast. Neck dissection is performed on the right side in regions I to V, preserving all non-lymphatic structures. The graft is then inserted into the defect and sutured into the defect first transorally and then transcervically. Suturing to the remaining gingiva, which is around 2 to 3 mm wide in the area of the lateral mandible, is extremely difficult. Prior to this, the bone was completely ground down with the drill, even if there was no macroscopic evidence of bone infiltration. After transoral fixation of the flap, the final adaptation is performed at the incision edges in the area of the lateral pharyngeal wall through the transcervical approach. This is followed by arterial anastomosis to the facial artery and 2 end-to-side anastomoses of the brachial veins to the internal jugular vein. Finally, defect coverage on the left forearm with split skin from the right thigh and appropriate wound dressings. Subsequently, insertion of a Redon suction drain on both sides and a flap in the area of the anastomosis with subsequent two-layer wound closure. Re-intubation of the patient onto an 8-gauge tracheostomy tube. Completion of the procedure and transfer of the patient to anesthesia. Conclusion: Transoral-transcervical resection of a large carcinoma of the floor of the mouth/basal tongue with defect coverage from the left forearm using a microvascularly anastomosed radial flap graft. Coverage on the left forearm with split skin from the right thigh. Additional tracheostomy and PEG placement. Intraoperative R0 resection after frozen section. \ No newline at end of file diff --git a/293/InvasionFront_CD3_block11_x3_y3_patient293_0.json b/293/InvasionFront_CD3_block11_x3_y3_patient293_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4dfaf031cd34bc1d4b894efca693f595399a2509 --- /dev/null +++ b/293/InvasionFront_CD3_block11_x3_y3_patient293_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10394.5, + "Centroid Y µm": 7396.1, + "Num Detections": 26501, + "Num Negative": 23819, + "Num Positive": 2682, + "Positive %": 10.12, + "Num Positive per mm^2": 1061.2 + } +} \ No newline at end of file diff --git a/293/InvasionFront_CD3_block11_x4_y3_patient293_1.json b/293/InvasionFront_CD3_block11_x4_y3_patient293_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f7d62e2e860f6d5932fce3b31cca6c5b39c281aa --- /dev/null +++ b/293/InvasionFront_CD3_block11_x4_y3_patient293_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12893.2, + "Centroid Y µm": 7346.1, + "Num Detections": 14603, + "Num Negative": 13709, + "Num Positive": 894, + "Positive %": 6.122, + "Num Positive per mm^2": 514.08 + } +} \ No newline at end of file diff --git a/293/InvasionFront_CD8_block11_x3_y3_patient293_0.json b/293/InvasionFront_CD8_block11_x3_y3_patient293_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b4d248fe07b0619e2b6e7b99a03c49071fb4d039 --- /dev/null +++ b/293/InvasionFront_CD8_block11_x3_y3_patient293_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13677.2, + "Centroid Y µm": 17983.8, + "Num Detections": 26561, + "Num Negative": 23901, + "Num Positive": 2660, + "Positive %": 10.01, + "Num Positive per mm^2": 1101.5 + } +} \ No newline at end of file diff --git a/293/InvasionFront_CD8_block11_x4_y3_patient293_1.json b/293/InvasionFront_CD8_block11_x4_y3_patient293_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f1a4f64a58d554c74315989eb40bd276b4e098dd --- /dev/null +++ b/293/InvasionFront_CD8_block11_x4_y3_patient293_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16278.7, + "Centroid Y µm": 17926.4, + "Num Detections": 7587, + "Num Negative": 7095, + "Num Positive": 492, + "Positive %": 6.485, + "Num Positive per mm^2": 593.85 + } +} \ No newline at end of file diff --git a/293/TumorCenter_CD3_block11_x3_y3_patient293_0.json b/293/TumorCenter_CD3_block11_x3_y3_patient293_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba2b79f3ab95932e49716ba3e8fc2d73785e29d7 --- /dev/null +++ b/293/TumorCenter_CD3_block11_x3_y3_patient293_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14417.4, + "Centroid Y µm": 7396.1, + "Num Detections": 23274, + "Num Negative": 20991, + "Num Positive": 2283, + "Positive %": 9.809, + "Num Positive per mm^2": 1048.4 + } +} \ No newline at end of file diff --git a/293/TumorCenter_CD3_block11_x4_y3_patient293_1.json b/293/TumorCenter_CD3_block11_x4_y3_patient293_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b53eba1ea38faf0ef8f2da2e51797cb21606077f --- /dev/null +++ b/293/TumorCenter_CD3_block11_x4_y3_patient293_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17091.0, + "Centroid Y µm": 7471.0, + "Num Detections": 25909, + "Num Negative": 23527, + "Num Positive": 2382, + "Positive %": 9.194, + "Num Positive per mm^2": 979.14 + } +} \ No newline at end of file diff --git a/293/TumorCenter_CD8_block11_x3_y3_patient293_0.json b/293/TumorCenter_CD8_block11_x3_y3_patient293_0.json new file mode 100644 index 0000000000000000000000000000000000000000..18faead6d731a7cdceba1214031ad733ba3874f5 --- /dev/null +++ b/293/TumorCenter_CD8_block11_x3_y3_patient293_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11918.7, + "Centroid Y µm": 7396.1, + "Num Detections": 19632, + "Num Negative": 18441, + "Num Positive": 1191, + "Positive %": 6.067, + "Num Positive per mm^2": 613.57 + } +} \ No newline at end of file diff --git a/293/TumorCenter_CD8_block11_x4_y3_patient293_1.json b/293/TumorCenter_CD8_block11_x4_y3_patient293_1.json new file mode 100644 index 0000000000000000000000000000000000000000..67c94e0251bacaa24dd4a83ffa52b97a47381f99 --- /dev/null +++ b/293/TumorCenter_CD8_block11_x4_y3_patient293_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14517.3, + "Centroid Y µm": 7421.1, + "Num Detections": 27789, + "Num Negative": 25970, + "Num Positive": 1819, + "Positive %": 6.546, + "Num Positive per mm^2": 725.23 + } +} \ No newline at end of file diff --git a/293/history_text.txt b/293/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/293/icd_codes.txt b/293/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed4aa87497852c75f601688357848e31931e81a2 --- /dev/null +++ b/293/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/293/ops_codes.txt b/293/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e76950ae0285a1cc8bfc6da660fb46846ace44b8 --- /dev/null +++ b/293/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] \ No newline at end of file diff --git a/293/patient_clinical_data.json b/293/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..65cdca18e01c5beeb637817079c0cb3f8fb24d4e --- /dev/null +++ b/293/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/293/patient_pathological_data.json b/293/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..aa01387a9be212c51979e60037e33d711fcf6457 --- /dev/null +++ b/293/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "293", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/293/surgery_description.txt b/293/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a26bb236510ab72d9508a96121d301be8a31142b --- /dev/null +++ b/293/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Bilateral neck dissection diff --git a/293/surgery_report.txt b/293/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a7bdbca9de71055132e6d87eb641c2ac45d8091d --- /dev/null +++ b/293/surgery_report.txt @@ -0,0 +1 @@ +After an initial consultation with the anesthesia colleagues, the patient is intubated and the tumor is inspected again after insertion of the mouth blocker. The tumor was found to be the same size as in the previous panendoscopy. The patient is then repositioned and tumor resection begins from the soft palate. Here, the tumor does not reach the uvula so that it can be preserved. However, the anterior and posterior palatal arches must be partially removed. Careful coagulation, dissection and partial ligation of the vessels are then performed. Dissection from cranial to caudal. The main tumor mass then begins in the area of the lower tonsil pole and moves into the hypopharynx and from there onto the pharyngoepiglottic fold. The dissection is performed in the layers of the parapharyngeal musculature. Larger arterial vessels are cut several times during dissection if there is a clear tendency to bleed. Dissection is now carried out in the direction of the pharynx. In the area of the glossotonsillar groove, the tumor extends slightly onto the base of the tongue, so that a partial resection must also be carried out in the area of the base of the tongue and the tonsil at the base of the tongue. Careful hemostasis is also required here. It now appears that the tumor is draining at the level of the hypopharynx and piriform sinus entrance and can be deposited here at the pharyngoepiglottic plica. A separate margin sample is then taken in the area of the caudal margin. The corresponding area on the tumor specimen is also marked with a thread. This margin sample and the tumor specimen are then sent for frozen section assessment. However, this shows that the marginal specimen in the area of the deposit margin at the base of the tongue cannot be assessed due to thermal alterations. The sedimentation margin sample in the area of the caudal sedimentation margin shows broad tumor infiltrates, so that the decision is made to reposition the patient and use the spreading laryngoscope to adjust the area of the hypopharynx and the caudal sedimentation area. This is done easily after insertion of the mouthguard. Then pre-segmentation under vision up to the hypopharynx and adjustment of the caudal tumor bed. The surgical microscope and CO2 laser are now added so that this area can be resected again over a large area with the laser. Again, careful bipolar coagulation of larger vessel stumps. A marginal sample is then taken again. Both the resected specimen and the marginal specimen are then sent again for frozen section assessment. The findings here are that broad tumor infiltrates can again be found in the post-resectate. The marginal sample is again strongly thermally altered, but shows no tumor infiltrates. However, due to the poor findings, a second margin sample was taken, which was then designated as margin sample caudal no. 3 and was again sent for frozen section. This is then found to be tumor-free, so that an R0 resection of the tumor can now be assumed. Therefore, after repeated careful hemostasis, the PEG tube is inserted. To do this, the flexible esophagoscope is inserted into the esophagus and the tube is advanced under visualization into the stomach, where the PEG tube can then be placed without difficulty if the diaphanoscopy is positive and the tent phenomenon is positive. This is done using the typical thread pull-through method. The patient is then mirrored back and the esophagus is carefully inspected again, where the mucosa is found to be normal. The patient is then repositioned for the tracheostomy. Inject local anesthetic with adrenaline on both sides of the neck as well as prelaryngeally and tracheally. A door incision is then made pretracheally and dissected in layers in depth. Pre-tracheal vein branches are then partly ligated and partly bipolar coagulated. The pretracheal musculature is then exposed, separated in the midline and dissected apart. Further layered dissection in depth and exposure of the thyroid isthmus. This is then undermined and, after separation of the isthmus, is ligated on both sides. Then expose the anterior surface of the trachea. Now enter the trachea between the 2nd and 3rd tracheal clasp. Dissection of the Björk flap. Then circular suturing and epithelialization of the tracheostoma. Then reintubation, which is also possible with an 8 mm tube. Now reposition the patient for neck dissection on the right side. First make a skin incision along the front edge of the sternocleidomastoid muscle. Then dissect in layers in depth after cutting through the platysma. Expose the cervical vascular sheath. In the cranial area, exposure and neurolysis, displacement and re-embedding of the auricularis magnus nerve. Then further dissection of the cervical vascular sheath in layers as far caudally as the omohyoid muscle and cranially to the digaster muscle. Here, lateral exposure of the accessorius nerve. Here too, neurolysis, displacement and re-embedding of the nerve. Then complete release of the lateral neck preparation from the accessorius triangle caudally, in the sense of levels II and III as well as IV and V. There is a lymph node conglomerate in the area of the vein angle, but this can be easily dissected away from the vein so that it can be well preserved. During dissection of the cervical vascular sheath, neurolysis, displacement and re-embedding of the vagus nerve. Subsequently, in the area of the hypoglossal triangle during preparation of the level Ib neck specimen. Then protection of all branches of the internal jugular vein and external carotid artery. Here also neurolysis, displacement and re-embedding of the hypoglossal nerve. The cervical profunda is also completely preserved during dissection and is also relocated and re-embedded in its course after neurolysis. Now dissection of the caudal medial neck preparation, where no conspicuous lymph nodes are found. All branches of the cervical plexus were also preserved during dissection of the lateral neck specimen. After significant arterial bleeding occurred intraoperatively in the area of the tumor resection, the decision was made to cut off the external carotid artery above the exit of the superior thyroid artery, which was then carried out without any problems after the external carotid artery had been clearly identified. The wound is then carefully irrigated. In summary, this results in a level Ib-V neck dissection. A Redon drain is then inserted. Two-layer wound closure and dressing. The patient is then repositioned for neck dissection on the left side. Here too, skin incision along the sternocleidomastoid muscle on the left side. Subsequent dissection in layers in depth. In the cranial area, neurolysis, exposure and protection of the auricularis magnus nerve, after displacement of the nerve cranially. Further layered preparation in depth after cutting through the platysma. Exposure of the cervical vascular sheath. Exposure of the caudal and cranial borders. Exposure, neurolysis and displacement as well as re-embedding of the accessorius nerve. Then, here too, release of the lateral neck preparation from the accessorius triangle caudally. Dissection of the venous angle and hypoglossal triangle. In doing so, protect all branches of the internal jugular vein and external carotid artery. Also exposure, neurolysis, displacement and re-embedding of the hypoglossal nerve with the cervical profunda. Then complete dissection of the anterior neck preparation. Here too, the branches and branches of the external carotid artery and internal jugular vein are preserved. During dissection, the vagus nerve is also exposed, neurolyzed, displaced and re-embedded. Here, too, careful hemostasis was performed. Overall, this also results in a level Ib-V neck dissection. A Redon drain is then inserted and the wound is closed in two layers. Once the dressing has been applied, the procedure is completed after another enoral bleeding check with dry wound conditions. The patient is ventilated via the tracheostoma and transferred to the in-house intensive care unit. Final consultation with the anesthesiologist. \ No newline at end of file diff --git a/294/InvasionFront_CD3_block19_x3_y10_patient294_0.json b/294/InvasionFront_CD3_block19_x3_y10_patient294_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4f169d64ced6bcebd0235fb01b49e0abb699b055 --- /dev/null +++ b/294/InvasionFront_CD3_block19_x3_y10_patient294_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 26960.7, + "Num Detections": 28249, + "Num Negative": 27579, + "Num Positive": 670, + "Positive %": 2.372, + "Num Positive per mm^2": 237.78 + } +} \ No newline at end of file diff --git a/294/InvasionFront_CD3_block19_x4_y10_patient294_1.json b/294/InvasionFront_CD3_block19_x4_y10_patient294_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c1b4c9d66cb900fbe848d991f9ed562dfd5bee1b --- /dev/null +++ b/294/InvasionFront_CD3_block19_x4_y10_patient294_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 27260.6, + "Num Detections": 17593, + "Num Negative": 16831, + "Num Positive": 762, + "Positive %": 4.331, + "Num Positive per mm^2": 447.91 + } +} \ No newline at end of file diff --git a/294/InvasionFront_CD8_block19_x3_y10_patient294_0.json b/294/InvasionFront_CD8_block19_x3_y10_patient294_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a6a4c7128465a2a879df031383f7a884ed90546 --- /dev/null +++ b/294/InvasionFront_CD8_block19_x3_y10_patient294_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11443.9, + "Centroid Y µm": 34706.6, + "Num Detections": 14705, + "Num Negative": 12337, + "Num Positive": 2368, + "Positive %": 16.1, + "Num Positive per mm^2": 1499.6 + } +} \ No newline at end of file diff --git a/294/InvasionFront_CD8_block19_x4_y10_patient294_1.json b/294/InvasionFront_CD8_block19_x4_y10_patient294_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f45170a4b143214485dafb0e3eb9b2c17cc0887e --- /dev/null +++ b/294/InvasionFront_CD8_block19_x4_y10_patient294_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 34956.5, + "Num Detections": 15244, + "Num Negative": 13061, + "Num Positive": 2183, + "Positive %": 14.32, + "Num Positive per mm^2": 1285.3 + } +} \ No newline at end of file diff --git a/294/TumorCenter_CD3_block19_x3_y10_patient294_0.json b/294/TumorCenter_CD3_block19_x3_y10_patient294_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0021a09af6705c097e41c335ca9000316a1d71af --- /dev/null +++ b/294/TumorCenter_CD3_block19_x3_y10_patient294_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13206.7, + "Centroid Y µm": 26009.9, + "Num Detections": 9267, + "Num Negative": 8713, + "Num Positive": 554, + "Positive %": 5.978, + "Num Positive per mm^2": 364.64 + } +} \ No newline at end of file diff --git a/294/TumorCenter_CD3_block19_x4_y10_patient294_1.json b/294/TumorCenter_CD3_block19_x4_y10_patient294_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2211c5abd823a90465bf47ba1c32132d50101a6 --- /dev/null +++ b/294/TumorCenter_CD3_block19_x4_y10_patient294_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15884.3, + "Centroid Y µm": 25692.9, + "Num Detections": 8943, + "Num Negative": 8336, + "Num Positive": 607, + "Positive %": 6.787, + "Num Positive per mm^2": 358.74 + } +} \ No newline at end of file diff --git a/294/TumorCenter_CD8_block19_x3_y10_patient294_0.json b/294/TumorCenter_CD8_block19_x3_y10_patient294_0.json new file mode 100644 index 0000000000000000000000000000000000000000..29edcafc5d2d7af6ae3117e6b1aa0692b1c70407 --- /dev/null +++ b/294/TumorCenter_CD8_block19_x3_y10_patient294_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 36230.8, + "Num Detections": 17905, + "Num Negative": 15990, + "Num Positive": 1915, + "Positive %": 10.7, + "Num Positive per mm^2": 957.16 + } +} \ No newline at end of file diff --git a/294/TumorCenter_CD8_block19_x4_y10_patient294_1.json b/294/TumorCenter_CD8_block19_x4_y10_patient294_1.json new file mode 100644 index 0000000000000000000000000000000000000000..758572b24b617c0541a43fddd0589efa8a76883a --- /dev/null +++ b/294/TumorCenter_CD8_block19_x4_y10_patient294_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 36230.8, + "Num Detections": 17248, + "Num Negative": 14950, + "Num Positive": 2298, + "Positive %": 13.32, + "Num Positive per mm^2": 1179.5 + } +} \ No newline at end of file diff --git a/294/history_text.txt b/294/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c38bfdd5a50df90d13eb6429c227529d42cb5e79 --- /dev/null +++ b/294/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed recurrence of a supraglottic laryngeal carcinoma on the right side. Sonographically, there is a yN2c neck status. \ No newline at end of file diff --git a/294/icd_codes.txt b/294/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7b3dfc242c7d0270e54c62c7e55e34db0c4a557a --- /dev/null +++ b/294/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/294/ops_codes.txt b/294/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d516ef9455bc5dd2f94c2bb7a1bdf7f120c98b6e --- /dev/null +++ b/294/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Selektive Neck dissection in 5 Regionen[5-403.04 B] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Permanente Tracheostomaanlage[5-312.0 ] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/294/patient_clinical_data.json b/294/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e8ce9f15d21cbc9fc1fd1bbc8302d96da3e7a7e3 --- /dev/null +++ b/294/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/294/patient_pathological_data.json b/294/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..75607d0b23672c8ecc3b84509a3321815ab75fa1 --- /dev/null +++ b/294/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "294", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/294/surgery_description.txt b/294/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3be436ffc30edcb5ffd6cb6bb5fc69dcaf177343 --- /dev/null +++ b/294/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection diff --git a/294/surgery_report.txt b/294/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b6f025031fb0a4ddff1e4d10f70a93ed38d7dc16 --- /dev/null +++ b/294/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Positioning of the patient and injection of local anesthetic with adrenaline in the area of the scar of the apron flap. Then skin incision along the old neck scar and preparation of an apron flap. Then exposure of the front edges of the sternocleidomastoid muscle on both sides. Start with the neck dissection on the right side. Exposure of the cervical vascular sheath. Long dissection of the cervical vascular sheath with the internal jugular vein and the carotid artery and its branches as well as the vagus nerve. Exposure of the accessorius nerve. Displacement, neurolysis and re-embedding of the vagus nerve and accessorius nerve. Exposure of the cervical plexus. A small lymph node conglomerate lateral to the vein can be seen caudal to the cervical plexus. This is excised. Careful hemostasis is performed. Dissection on the deep cervical fascia cranially up to the accessorius triangle. The hypoglossal triangle and the anterior neck preparation are also excised. Overall, there is massive scarring here, which is why the preparation conditions are significantly more difficult. Transition to the left side. Slightly less scarring here and therefore easier preparation. However, after exposing the cervical vascular sheath, the lateral neck preparation is still relatively complete. Therefore, exposure of the accessorius nerve, displacement, neurolysis and re-embedding of the accessorius nerve and removal of the lateral neck preparation. Subsequently, the hypoglossal triangle and the anterior neck preparation were exposed and evacuated while sparing all branches of the external carotid artery and the internal jugular vein. On the right side, the facial vein was ligated. This results in neck revisions of levels Ib, II, III, IV and V on both sides. This is released cranially. This is followed by caudal release of the infrahyoid muscles. Separation of the prelaryngeal musculature in the median line so that the infrahyoid musculature and infralaryngeal musculature can be dissected away to the side. This exposes the laryngeal framework. The tumor does not appear to have penetrated the larynx on the right side, the cartilaginous border is intact here. Dissection up to the exposure of the cricoid cartilage. Dissection of the anterior wall of the trachea. Separation of the scarred parts of the thyroid gland. Hardened or suspicious nodules are not palpable in the thyroid gland if multinodular goiter is known. Visualization of the old scar of the former tracheotomy. Enter the trachea and prepare a visor tracheotomy. Subsequent intubation via an endotracheal tube via the tracheostoma and removal of the nasal tube placed by the anesthesia colleagues. Insertion of a McIvor blade into the vallecula and opening of the pharynx. Widen the pharyngeal opening so that the restepiglottis is visible. The supraglottic tumor described on the right side can now be seen in the view. Partial resection of the restepiglottis and caudal dissection. The dissection is performed above the level of the ligament. Lateral incision on the right side. Here it can be seen that the tumor has grown subepithelially paraglottically to far caudally, well below the vocal cord level. There is extensive tumor infestation here, which no longer allows partial laryngeal resection, so a switch is made to total laryngectomy. This completely exposes the lateral edges of the thyroid cartilage and dissects the pharyngeal wall. Complete the incision via the aryepiglottic fold of the right side into the postcricoid region so that the pharynx can be separated from the larynx here by cutting around the aryepiglottic fold of the right side, which is completely consumed by the tumor. Further dissection caudally at the posterior edge of the larynx up to the cricoid cartilage plate. The larynx is then deposited below the cricoid cartilage. Examination of the specimen. The tumor is resected in sano. Despite this, marginal samples are taken from the base of the tongue. It appears that the tumor may have invaded this area. The tissue appears conspicuously hardened and somewhat restless, so that a small portion of the base of the tongue is resected first. A marginal sample is then taken for a frozen section assessment. Also take marginal samples from both pharyngeal side walls and the postcricoid region. All marginal samples are assessed as tumor-free. Insertion of the Provox prosthesis in the form of a Provox 2 size 6 at the typical location. Subsequent closure of the pharynx after myotomy on both sides. The pharynx is closed with single button sutures and then in a second layer using continuous sutures. TachoSil is glued to the ends on both sides and to the intersection of the horizontal and vertical pharyngeal suture. Suture the infrahyoid muscles in front of the pharynx again. Then release the medial parts of the insertion of the sternocleidomastoid muscle to prevent the tracheostoma from sinking in deeply for later treatment. Repeated careful hemostasis. Insertion of large Redon drains into the neck on both sides. Two-layer wound closure of the apron flap and circular suturing of the tracheostoma. Application of a pressure bandage on both sides. A nasogastric tube was placed in the patient at the beginning of the operation. This is now reattached and remains in place. The patient received intravenous antibiotics preoperatively and at the end of the operation, which were to be continued for 3 days postoperatively. Final consultation with the anesthesia department. The patient is kept awake in the in-house intensive care unit for monitoring. \ No newline at end of file diff --git a/295/InvasionFront_CD3_block15_x3_y1_patient295_0.json b/295/InvasionFront_CD3_block15_x3_y1_patient295_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4bff1d694fe4492d29dd3464070ef52fd858fa18 --- /dev/null +++ b/295/InvasionFront_CD3_block15_x3_y1_patient295_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12393.4, + "Centroid Y µm": 12543.4, + "Num Detections": 18617, + "Num Negative": 18526, + "Num Positive": 91, + "Positive %": 0.4888, + "Num Positive per mm^2": 33.83 + } +} \ No newline at end of file diff --git a/295/InvasionFront_CD3_block15_x4_y1_patient295_1.json b/295/InvasionFront_CD3_block15_x4_y1_patient295_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1d1701c3712de8cc984b7e7b74387653a8789ba2 --- /dev/null +++ b/295/InvasionFront_CD3_block15_x4_y1_patient295_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15017.0, + "Centroid Y µm": 12443.4, + "Num Detections": 18781, + "Num Negative": 18615, + "Num Positive": 166, + "Positive %": 0.8839, + "Num Positive per mm^2": 64.11 + } +} \ No newline at end of file diff --git a/295/InvasionFront_CD8_block15_x3_y1_patient295_0.json b/295/InvasionFront_CD8_block15_x3_y1_patient295_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6d819ed4b2ffd70ea47550de9b3194774a61057a --- /dev/null +++ b/295/InvasionFront_CD8_block15_x3_y1_patient295_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10961.1, + "Centroid Y µm": 2488.3, + "Num Detections": 15358, + "Num Negative": 15336, + "Num Positive": 22, + "Positive %": 0.1432, + "Num Positive per mm^2": 8.935 + } +} \ No newline at end of file diff --git a/295/InvasionFront_CD8_block15_x4_y1_patient295_1.json b/295/InvasionFront_CD8_block15_x4_y1_patient295_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c16b4767b3b5481893466c6f44c43dfbfeff15a --- /dev/null +++ b/295/InvasionFront_CD8_block15_x4_y1_patient295_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13564.4, + "Centroid Y µm": 2455.4, + "Num Detections": 17494, + "Num Negative": 17414, + "Num Positive": 80, + "Positive %": 0.4573, + "Num Positive per mm^2": 33.81 + } +} \ No newline at end of file diff --git a/295/TumorCenter_CD3_block15_x3_y1_patient295_0.json b/295/TumorCenter_CD3_block15_x3_y1_patient295_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f55c3b56ea4d2a664743fb9a2d89e481f9880471 --- /dev/null +++ b/295/TumorCenter_CD3_block15_x3_y1_patient295_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11443.9, + "Centroid Y µm": 5771.9, + "Num Detections": 16270, + "Num Negative": 16117, + "Num Positive": 153, + "Positive %": 0.9404, + "Num Positive per mm^2": 61.23 + } +} \ No newline at end of file diff --git a/295/TumorCenter_CD3_block15_x4_y1_patient295_1.json b/295/TumorCenter_CD3_block15_x4_y1_patient295_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5270afa70a8de10d0af87819526ca1e07ad02ec6 --- /dev/null +++ b/295/TumorCenter_CD3_block15_x4_y1_patient295_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13992.6, + "Centroid Y µm": 5771.9, + "Num Detections": 14413, + "Num Negative": 14247, + "Num Positive": 166, + "Positive %": 1.152, + "Num Positive per mm^2": 68.69 + } +} \ No newline at end of file diff --git a/295/TumorCenter_CD8_block15_x3_y1_patient295_0.json b/295/TumorCenter_CD8_block15_x3_y1_patient295_0.json new file mode 100644 index 0000000000000000000000000000000000000000..192e5f6fd2ef2bf9564ae84cfc788c60945b4718 --- /dev/null +++ b/295/TumorCenter_CD8_block15_x3_y1_patient295_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 2579.9, + "Num Detections": 16523, + "Num Negative": 16511, + "Num Positive": 12, + "Positive %": 0.0726, + "Num Positive per mm^2": 4.971 + } +} \ No newline at end of file diff --git a/295/TumorCenter_CD8_block15_x4_y1_patient295_1.json b/295/TumorCenter_CD8_block15_x4_y1_patient295_1.json new file mode 100644 index 0000000000000000000000000000000000000000..392be1fcd3a7ca145a6d3c0b40eb65c15f8ac6d2 --- /dev/null +++ b/295/TumorCenter_CD8_block15_x4_y1_patient295_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 2529.9, + "Num Detections": 16410, + "Num Negative": 16402, + "Num Positive": 8, + "Positive %": 0.0488, + "Num Positive per mm^2": 3.436 + } +} \ No newline at end of file diff --git a/295/history_text.txt b/295/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8cab5b5a813cb9c4b98a03bd47a87fbabdb9529c --- /dev/null +++ b/295/history_text.txt @@ -0,0 +1 @@ +The patient underwent a panendoscopy and a cT3 cN2b oral cavity carcinoma on the right side was histologically confirmed as the most likely secondary malignancy in a case of tongue margin carcinoma on the left with primary surgical treatment and adjuvant interstitial brachytherapy. The surgical procedure was recommended in our interdisciplinary tumor conference. Computed tomography showed an extensive mass in the area of the right floor of the mouth and the edge of the tongue with infiltration of the base of the tongue and almost per continuitatem growth towards the neck metastasis. In addition, contact with the mandibular branch without clear signs of infiltration. Rapid clinical progression of the tumor. \ No newline at end of file diff --git a/295/icd_codes.txt b/295/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..92b548ccdc1f72f69c8514a3142c9ee1e02d6b4a --- /dev/null +++ b/295/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Mund mehrere Teilbereiche überlappend[C06.8 R] \ No newline at end of file diff --git a/295/ops_codes.txt b/295/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7faaf95fbf92d3e668bf1d74c9aa93d7e9a122f4 --- /dev/null +++ b/295/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Transplantat[5-296.14 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Vollhaut Entnahmestelle Leisten- und Genitalregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 R] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Exzision von Schilddrüsengewebe[5-062.0 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Endoskopische Biopsie am Ösophagus[1-440.a ] \ No newline at end of file diff --git a/295/patient_clinical_data.json b/295/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5958d066495a204615c7da8d21d00560527f209b --- /dev/null +++ b/295/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/295/patient_pathological_data.json b/295/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f4d73ccac779cc7c56f96b18780aa067238b5c1d --- /dev/null +++ b/295/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "295", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT4a", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/295/surgery_description.txt b/295/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9cd599154435eb1f3acb67d2371d13c99fd9c92c --- /dev/null +++ b/295/surgery_description.txt @@ -0,0 +1 @@ +Combined tumor resection, Defect reconstruction, Right neck dissection, PEG placement, Tracheotomy diff --git a/295/surgery_report.txt b/295/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e92848906d2742e9d5f5dbb04ad716f3f8bf2bfe --- /dev/null +++ b/295/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Bronchoscopic intubation by the anesthesia colleagues. Positioning of the patient. Firstly, the PEG is inserted. For this purpose, insertion with the gastroscope under laryngoscopic control. Easy visualization of the stomach, whereby a partly exophytic, fleshy change can be seen in the area of the distal esophagus at the transition to the stomach entrance. Rather blurred boundaries. Multiple samples are therefore taken. The stomach is inconspicuous and clear on inspection, so that if diaphanoscopy is very good, the stomach is punctured without any problems and the PEG tube is then inserted using the usual thread pull-through method. Repositioning and inspection of the primary tumor region. An exulcerated tumor is seen in the area of the lateral floor of the mouth, extending into the anterior floor of the mouth to just below the midline, infiltrating the right-sided caruncle and directly approaching the alveolar ridge in the anterior and lateral floor of the mouth. Infiltration of the tooth pocket of the remaining canine. Infiltration of the edge of the tongue and extensive deep infiltration of the tissue towards the soft tissue and muscular floor of the mouth as well as towards the base of the tongue. The canine or lower incisor is therefore extracted first. Some of the teeth here are extensively decayed. Incision of the gingiva in the area of the alveolar ridge anteriorly and laterally, laterally of the lower jaw and subsequent removal of the entire mucosa with the periosteum from the bone. In the anterior and lateral areas, it can be seen that the tumor has consumed the periosteum and is located in the bone for a long distance. There are no clear signs of infiltration with erosion or destruction of the bone, so the decision is made to resect the tumor while preserving continuity. Resection of the lateral edge of the tongue with a sufficient safety margin up to the dorsal side and detachment of the floor of the mouth down to the depths with detachment of the musculature and detachment for later completion of the resection from the transcervical side. The entire exposed mucosal area is now covered with margin samples. These are shown to be completely free of tumor and dysplasia in the frozen section diagnosis. Repositioning of the patient for transcervical resection and neck dissection for cN2b neck status. After injection of Ultracaine with added adrenaline, the horizontal incision is made. Cut through skin and subcutaneous tissue. Dissection of the platysma. Dissection of the platysma. Exposure of the sternocleidomastoid muscle and preservation of the external jugular vein. Exposure of the omohyoid muscle. Release of the submandibular gland and exposure of the digastric muscle. Dissection of the cranial aspect of the sternocleidomastoid muscle shows that the mass is at least close to the muscle and appears slightly compressed. It was therefore decided to resect the cranial part of the muscle. Later, the posterior venter of the digastric muscle is also extirpated, as it is also cemented to the cervical conglomerate, which is largely localized in levels II and III. Free dissection of the internal jugular vein with exposure of the common carotid artery, vagus nerve, cervical plexus and cervical sinus. The aforementioned structures are microsurgically neurolyzed and relocated. Subsequent re-embedding of the aforementioned structures. Inclusion up to level V a. Anterior preservation of the superior thyroid artery. The facial vein must be removed in the event of infiltration, as must the accessorius and hypoglossal nerves. In addition, the facial artery and lingual artery must be removed, also in the case of infiltration. The internal jugular vein is clearly visible in the cranial part............................., but is not infiltrated and can be preserved in its continuity. Now dislocation of the submandibular gland. Level I b shows numerous and conspicuously enlarged lymph nodes. These are completely extirpated. Raising of the ramus marginalis mandibulae. Neurolysis and cranial displacement and re-embedding of the same. Resection sharply on the mandible and completion for resection enorally. In the case of pervasive growth in the area of the muscles of the floor of the mouth, removal of large areas of the affected muscles, macroscopically clearly in sano. It can be seen that a tumor formation is also growing submucosally into the right tonsil lobe. Therefore, the tonsillar lobe is included. Inclusion of the pharyngeal side wall on the affected side with extensive submucosal tumor growth and extirpation of the tumor, macroscopically especially in the soft tissue area in toto. The coverage is now completed with mucosal margin samples. These are again free of tumor and dysplasia in the frozen section. Marking of the specimen, especially the parts of the tumor close to the mandible and thus exposed. Final inspection of the mandible. Still no signs of destruction here. Therefore, the lower jaw is first significantly reduced over the entire exposed area using the rose bur. Grind down the tooth pockets of the extracted teeth close to the tumor. Then complete grinding with the diamond bur. Finally, vital and regular bone, so that an R0 situation can be assumed. After measuring the defect, the radialis graft is removed from the left forearm. Lifting of a graft measuring approx. 14x7 cm in total with mouth base and tongue edge configuration. Lifting of the graft in a bloodless state. First radial incision of the graft. Exposure of the brachioradialis muscle. Exposure and securing of the superficial ramus, radial nerve. Distal exposure of the radial vasa and removal. Ulnar preparation. Subfascial release of the graft. Cranial preparation and tracing of the pedicle. The cephalic vein is preserved and remains in situ. After ensuring the outlet of the ulnar artery, isolate the graft to the radial artery and two stronger draining veins in the area of the deep system. Reopening of the tourniquet. Regular hand perfusion. Good graft perfusion. Careful hemostasis in the area of the graft and in the area of the forearm and removal of the vital graft. After hemostasis, the wound is carefully closed in two layers in the area of the forearm and the full-thickness skin graft harvested from the right groin is implanted. A vacuum sealing pump was then applied and the Cramer splint was placed in the functional position. At the same time, the transplant was implanted. This is performed transorally and transcervically. Finally, exact fit and good reconstruction with preservation of tongue mobility. Tight conditions on all sides. Conditioning of the vascular pedicle. Preparation of the superior thyroid artery. Performing the arterial anastomosis with 8.0 Ethilon. This works well despite the difference in caliber. Immediate regular venous return. Conditioning of the venous stump of the facial vein. Measurement of a size 3.5 coupler. Problem-free performance of the venous anastomosis with the coupler system. Subsequent correct pedicle position. Positive spreading phenomenon and regular enoral graft perfusion so that, after careful wound inspection, a 10-gauge Redon drain is inserted and the wound is carefully closed in two layers. Finally, the tracheotomy is performed. A horizontal incision is made at the level of the cricoid cartilage. Cut through the skin and subcutaneous tissue. Expose the infrahyoid musculature. Entering the linea alba. This reveals a grayish, dark mass with soft tissue that cannot be further differentiated macroscopically. This does not initially appear to originate directly from the thyroid gland. Extirpation of the tissue on visualization of the cricoid cartilage. Another clear mass, but most likely in the sense of altered thyroid cysts or originating from the thyroid tissue. Resection as far as necessary for tracheotomy. The tissue is sent for definitive histology. Careful treatment of the thyroid gland, no dissection in the direction of the recurrent nerves. Insertion between the 2nd and 3rd tracheal ring. Creation of a wide visor tracheotomy and incision of the skin. Subsequent problem-free transfer to a size 9 low-cuff cannula, which is suture-fixed. The procedure is then completed. Final consultation with the anesthetist. Conclusion: Intraoperative R0-resected cT4a cN2b oral cavity carcinoma with extensive contact to the mandible. Intraoperative tissue biopsies in the distal esophagus and pretracheal region, most likely as dependent diagnoses. Please monitor the graft carefully postoperatively. Continue the intraoperative intravenous antibiotic treatment with Unacid 3 g for 24 hours. If the enoral graft heals properly, the first swallowing diagnostics can be carried out from the 8th postoperative day with initiation of the diet if necessary. \ No newline at end of file diff --git a/296/InvasionFront_CD3_block1_x1_y1_patient296_0.json b/296/InvasionFront_CD3_block1_x1_y1_patient296_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6ff35b6459a8553ddc3fed6be419ec10d2f4703 --- /dev/null +++ b/296/InvasionFront_CD3_block1_x1_y1_patient296_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4547.6, + "Centroid Y µm": 4272.7, + "Num Detections": 18856, + "Num Negative": 18317, + "Num Positive": 539, + "Positive %": 2.859, + "Num Positive per mm^2": 243.23 + } +} \ No newline at end of file diff --git a/296/InvasionFront_CD3_block1_x2_y1_patient296_1.json b/296/InvasionFront_CD3_block1_x2_y1_patient296_1.json new file mode 100644 index 0000000000000000000000000000000000000000..57a684163e9cc970b2645807ad7bd0de4ed075fb --- /dev/null +++ b/296/InvasionFront_CD3_block1_x2_y1_patient296_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7071.3, + "Centroid Y µm": 4247.8, + "Num Detections": 18118, + "Num Negative": 17585, + "Num Positive": 533, + "Positive %": 2.942, + "Num Positive per mm^2": 244.14 + } +} \ No newline at end of file diff --git a/296/InvasionFront_CD8_block1_x1_y1_patient296_0.json b/296/InvasionFront_CD8_block1_x1_y1_patient296_0.json new file mode 100644 index 0000000000000000000000000000000000000000..453df96bcd77622c14960fe6226770af75a69abd --- /dev/null +++ b/296/InvasionFront_CD8_block1_x1_y1_patient296_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4772.5, + "Centroid Y µm": 2473.7, + "Num Detections": 19398, + "Num Negative": 17721, + "Num Positive": 1677, + "Positive %": 8.645, + "Num Positive per mm^2": 739.47 + } +} \ No newline at end of file diff --git a/296/InvasionFront_CD8_block1_x2_y1_patient296_1.json b/296/InvasionFront_CD8_block1_x2_y1_patient296_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1d75c24d2b41f04b1db37790d7a441d4efe1706c --- /dev/null +++ b/296/InvasionFront_CD8_block1_x2_y1_patient296_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7396.1, + "Centroid Y µm": 2623.6, + "Num Detections": 18011, + "Num Negative": 17342, + "Num Positive": 669, + "Positive %": 3.714, + "Num Positive per mm^2": 318.73 + } +} \ No newline at end of file diff --git a/296/TumorCenter_CD3_block1_x1_y2_patient296_0.json b/296/TumorCenter_CD3_block1_x1_y2_patient296_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14be91313ac6addc0769b502f6e1871a36f5b0e3 --- /dev/null +++ b/296/TumorCenter_CD3_block1_x1_y2_patient296_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3198.3, + "Centroid Y µm": 5946.9, + "Num Detections": 16675, + "Num Negative": 13806, + "Num Positive": 2869, + "Positive %": 17.21, + "Num Positive per mm^2": 1360.7 + } +} \ No newline at end of file diff --git a/296/TumorCenter_CD3_block1_x2_y2_patient296_1.json b/296/TumorCenter_CD3_block1_x2_y2_patient296_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d32b5504d786a40db4a281e503dc26d175553718 --- /dev/null +++ b/296/TumorCenter_CD3_block1_x2_y2_patient296_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5703.0, + "Centroid Y µm": 5829.6, + "Num Detections": 14333, + "Num Negative": 11316, + "Num Positive": 3017, + "Positive %": 21.05, + "Num Positive per mm^2": 1716.2 + } +} \ No newline at end of file diff --git a/296/TumorCenter_CD8_block1_x1_y1_patient296_0.json b/296/TumorCenter_CD8_block1_x1_y1_patient296_0.json new file mode 100644 index 0000000000000000000000000000000000000000..06892dde4d357240b2a74bb278fc082e709a9c47 --- /dev/null +++ b/296/TumorCenter_CD8_block1_x1_y1_patient296_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 11718.8, + "Num Detections": 17721, + "Num Negative": 17535, + "Num Positive": 186, + "Positive %": 1.05, + "Num Positive per mm^2": 86.92 + } +} \ No newline at end of file diff --git a/296/TumorCenter_CD8_block1_x2_y1_patient296_1.json b/296/TumorCenter_CD8_block1_x2_y1_patient296_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e26a9cf96f9abd9e9771cd831788d34efd882f9c --- /dev/null +++ b/296/TumorCenter_CD8_block1_x2_y1_patient296_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8745.4, + "Centroid Y µm": 11593.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/296/history_text.txt b/296/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b73b49f4689f56676bcf3264e607d0534201b6b2 --- /dev/null +++ b/296/history_text.txt @@ -0,0 +1 @@ +Patient with confirmed squamous cell carcinoma of the left oropharynx, already classified preoperatively as cT3 in the current CT growth in the area of the posterior wall of the oropharynx, in part beyond the midline. Patient has multiple risk factors including systemic lupus erythematosus, renal insufficiency, pulmonary fibrosis, etc. Therefore, in view of the fact that this tumor cannot be treated with RCTE, the only possible curative treatment is surgical resection. \ No newline at end of file diff --git a/296/icd_codes.txt b/296/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0d0f4db307b38887294336b756e439993e2ec53 --- /dev/null +++ b/296/icd_codes.txt @@ -0,0 +1 @@ +Oropharynxkarzinom[C10.9 ] \ No newline at end of file diff --git a/296/ops_codes.txt b/296/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..613fe03e893b74a96e3d41fa7ed64a254e0e07b6 --- /dev/null +++ b/296/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Perkutan-endoskopische Gastrostomie[5-431.2 ] Permanente Tracheostomaanlage[5-312.0 ] Transplantat[5-295.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Transplantat[5-295.14 ] Entnahme eines myokutanen Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-858.28 R] \ No newline at end of file diff --git a/296/patient_clinical_data.json b/296/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d4ccdf4f60b6616fbd268c6650ae5ad3b44ba49b --- /dev/null +++ b/296/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 55, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 30, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/296/patient_pathological_data.json b/296/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b9637f3265a5d7c174f8943b21b6e1ce59ffeb53 --- /dev/null +++ b/296/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "296", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 35, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Sarcomatoid", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/296/surgery_description.txt b/296/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b11214d10dd336a7f338b5c7ef85a5ec5ef6ec7a --- /dev/null +++ b/296/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Free flap coverage (ALT), Tracheostomy, PEG placement diff --git a/296/surgery_report.txt b/296/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b7e7c9056230446531585b187f56c6c324e664ae --- /dev/null +++ b/296/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy again: The extensive tumor is visible, which runs from the right palatal arch over the tonsillar lobe into the base of the tongue. Growth in the posterior pharyngeal wall and there partly over the midline. Further smaller mucosal changes are clearly visible beyond the midline. Here mainly multicentric growth or satellite foci. Growth also up to the entrance of the hypopharynx. Growth into the base of the tongue and into the left vallecula or epiglottis. Therefore now at least cT3, more likely cT4 findings. Above mentioned OP confirmed. PEG placement: Entering the stomach with the flexible esophagoscope. After creating the diaphanoscopy, insertion of a 15 mm abdominal wall tube in a typical manner without complications. Fixation to the abdominal wall. Sterile draping of all surgical regions including the upper arm, thigh and pectoralis major area. Then start with transcervical, transoral resection: First insert the Mc Ivor blade. Tumor is cut around on all sides with a safety margin of at least 1.5 cm. Resection includes parts of the right palatal arch, entire lateral wall of the oropharynx, entire posterior wall of the oropharynx, glossoalveolar groove, from here the body of the tongue and almost half of the base of the tongue are resected. From enorally, marginal samples are taken from the palatal arch area, alveolar ridge, tongue body area, tongue base area and medial pharyngeal area. A marginal sample is also taken from the cranial, basal area. All marginal samples are tumor-free in the frozen section. The operation is continued from transcervical with neck dissection on the left: Submandibular section which is extended caudally along the sternocleidomastoid muscle. First exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle, digastric muscle. Exposure of the cervical vascular sheath, internal jugular vein, external jugular vein, internal carotid artery, external carotid artery. Exposure of vagus nerve, hypoglossal nerve, accessorius nerve. All structures are preserved. Visualization of vascular outlets from the. A. carotis externa, A. superior and lingualis as well as facialis can be visualized. Facialis is visualized up to the mandible and can be preserved. V. facialis and V. thyroidea superior are also visualized and preserved. Levels 1 to 5 are cleared in the typical manner, taking the submandibular gland with them. The digastric muscle and styloid and stylopharyngeal muscles are then resected. Tumor resection is now completed from the inside out, taking the entire pharyngeal wall with it and cutting around the entire tumor area. The tumor is pulled outwards and the resection is continued. This is followed by resection of 2/3 of the epiglottis and the left-sided vallecula area as well as almost the entire pre-epiglottic fatty tissue. The resection extends caudally to the hypopharyngeal entrance. A further satellite-like tumor can be seen further down, which indicates multicentric growth. Resection is therefore extended into the piriform sinus. Now take marginal samples from the caudal tongue base or vallecula area, caudal basal as well as a marginal sample from parapharyngeal tissue which is still located on the large vessels. The tumor is also sent in thread-marked to assess the basal margins or the caudal resection area in the area of the aryepiglottic fold and piriform sinus. Small focal or in situ infiltrations are still reported in the area of the vallecula, in the area of the piriform sinus and in the direction of the aryepiglottic fold. Vallecula is already secured by a marginal sample. This is followed by a further resection in the area of the entire aryepiglottic fold and piriform sinus. Subsequently, another margin sample, which is again thread-marked for frozen section. Finally, no more tumor infiltration can be seen here, so that ultimately a RO resection is surgically achieved. This is followed by the neck dissection on the right side. Here, level 2 to 5 is typically removed while preserving all structures. After measuring the defect, a corresponding, three-dimensional........ of the defect 12 x up to 10 cm resulting flap is marked in the area of the right thigh after marking several perforators around it. Then flap elevation on the right from the medial side, exposing the vascular pedicle. Then also from the lateral, subfascial side. The flap is lifted with the attached vastus lateralis muscle due to the perforators running through the muscle. Vascular pedicle is traced cranially. Small branches are ligated or clipped. The descending ramus or a common vein is placed cranially and supplied with 4 puncture ligatures. Due to the thick layer of fat, the deeper fatty tissue is removed and the flap is thinned. After hemostasis, the wound area in the thigh is treated in several layers with the insertion of 2 Redon drains. The thigh flap is then inserted into the defect and successively sutured in place without tension using 3.0 Vicryl single-button sutures, partly with the sutures in place. An anatomically correct, complete, tension-free closure is achieved. The vascular anastomosis is then performed. After conditioning the vessel ends, the superior thyroid artery and descending ramus are anastomosed using 8.0 Ethilon single-button sutures. After opening the clamp, good arterial flow and good venous return. Subsequent conditioning of the facial vein or the vein from the vascular pedicle. A size 3.0 coupler is selected. Coupler anastomosis without complications. After opening the clamp, good venous flow, positive smear phenomenon. This is followed by careful hemostasis of the neck on both sides and layered wound closure with insertion of a Redon drain on both sides. Particular care is taken on the left side to ensure that the vascular pedicle is not kinked, and the region for checking the vascular pedicle using Doppler is marked. During the procedure, a tracheostoma was created between the 2nd and 3rd tracheal cartilage using a small Kocher's collar incision in the typical manner. Epithelialization via a wide pedicled Björk flap in a typical manner. At the end of the operation, a tracheostomy tube with a core is inserted and sutured in place. Dressing on the right side. No dressing on the left side. Patient became dangerously catecholamine-dependent several times during the operation, so that a suprarenin perfusor also had to be connected. Due to the risk factors and the patient's relatively unstable circulatory situation, she was transferred to the interdisciplinary surgical intensive care unit. Heparin perfusor, which was started intraoperatively, should be continued at 500 E/hour for 5 days. Antibiotics started intraoperatively with Ciprobay should be continued for one week. Feeding via the inserted PEG tube for 10 days, then gruel and, if necessary, diet build-up. Control of the flap via enoral inspection and Doppler sonography at the marked neck site in a typical manner according to the scheme. Due to the extent of the tumor, at least one RT, if not an RCT, is certainly indicated postoperatively, provided this is possible for the patient. \ No newline at end of file diff --git a/297/InvasionFront_CD3_block22_x3_y6_patient297_0.json b/297/InvasionFront_CD3_block22_x3_y6_patient297_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f749c24086ed94532903e729e81e09efe7382709 --- /dev/null +++ b/297/InvasionFront_CD3_block22_x3_y6_patient297_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12043.6, + "Centroid Y µm": 26535.9, + "Num Detections": 18483, + "Num Negative": 14947, + "Num Positive": 3536, + "Positive %": 19.13, + "Num Positive per mm^2": 1693.0 + } +} \ No newline at end of file diff --git a/297/InvasionFront_CD3_block22_x4_y6_patient297_1.json b/297/InvasionFront_CD3_block22_x4_y6_patient297_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ec06c9b4b019f83c66a115c06d00adc276f88485 --- /dev/null +++ b/297/InvasionFront_CD3_block22_x4_y6_patient297_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14492.3, + "Centroid Y µm": 26511.0, + "Num Detections": 17450, + "Num Negative": 13836, + "Num Positive": 3614, + "Positive %": 20.71, + "Num Positive per mm^2": 1781.1 + } +} \ No newline at end of file diff --git a/297/InvasionFront_CD8_block22_x3_y6_patient297_0.json b/297/InvasionFront_CD8_block22_x3_y6_patient297_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bee9d6b8b26e1cb2d8919746b8fc8e97fdde9dca --- /dev/null +++ b/297/InvasionFront_CD8_block22_x3_y6_patient297_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 14992.1, + "Num Detections": 18423, + "Num Negative": 15717, + "Num Positive": 2706, + "Positive %": 14.69, + "Num Positive per mm^2": 1378.9 + } +} \ No newline at end of file diff --git a/297/InvasionFront_CD8_block22_x4_y6_patient297_1.json b/297/InvasionFront_CD8_block22_x4_y6_patient297_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ad16b2f45243c3bdb521571271f53a4a96c308a2 --- /dev/null +++ b/297/InvasionFront_CD8_block22_x4_y6_patient297_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16716.1, + "Centroid Y µm": 14842.1, + "Num Detections": 16108, + "Num Negative": 12029, + "Num Positive": 4079, + "Positive %": 25.32, + "Num Positive per mm^2": 2053.4 + } +} \ No newline at end of file diff --git a/297/TumorCenter_CD3_block22_x3_y6_patient297_0.json b/297/TumorCenter_CD3_block22_x3_y6_patient297_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c1b256c3c352f9565aa85ac6efd07dc546002469 --- /dev/null +++ b/297/TumorCenter_CD3_block22_x3_y6_patient297_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11718.8, + "Centroid Y µm": 15441.8, + "Num Detections": 14442, + "Num Negative": 13405, + "Num Positive": 1037, + "Positive %": 7.18, + "Num Positive per mm^2": 639.04 + } +} \ No newline at end of file diff --git a/297/TumorCenter_CD3_block22_x4_y6_patient297_1.json b/297/TumorCenter_CD3_block22_x4_y6_patient297_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4902f96619b03f6acab69b91c77dac7ea6e0207c --- /dev/null +++ b/297/TumorCenter_CD3_block22_x4_y6_patient297_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 15516.8, + "Num Detections": 14085, + "Num Negative": 12538, + "Num Positive": 1547, + "Positive %": 10.98, + "Num Positive per mm^2": 924.86 + } +} \ No newline at end of file diff --git a/297/TumorCenter_CD8_block22_x3_y6_patient297_0.json b/297/TumorCenter_CD8_block22_x3_y6_patient297_0.json new file mode 100644 index 0000000000000000000000000000000000000000..995b38235ee23da92b23842bdbf561f991555b82 --- /dev/null +++ b/297/TumorCenter_CD8_block22_x3_y6_patient297_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 24811.9, + "Num Detections": 15138, + "Num Negative": 14067, + "Num Positive": 1071, + "Positive %": 7.075, + "Num Positive per mm^2": 588.95 + } +} \ No newline at end of file diff --git a/297/TumorCenter_CD8_block22_x4_y6_patient297_1.json b/297/TumorCenter_CD8_block22_x4_y6_patient297_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3e3785305be7847a094edeea04eb6b2c82c30002 --- /dev/null +++ b/297/TumorCenter_CD8_block22_x4_y6_patient297_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 24911.8, + "Num Detections": 14636, + "Num Negative": 12114, + "Num Positive": 2522, + "Positive %": 17.23, + "Num Positive per mm^2": 1353.8 + } +} \ No newline at end of file diff --git a/297/history_text.txt b/297/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/297/icd_codes.txt b/297/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cb61ab7f62545e87e6058f0f4ecf99e5cc265b55 --- /dev/null +++ b/297/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Regio postcricoidea[C13.0 ] Bösartige Neubildung sekundär und onA Lymphknoten mehrere Regionen[C77.8 B] \ No newline at end of file diff --git a/297/ops_codes.txt b/297/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5dafe1f86c3b079655ccc9e15f0165a5d369a5c5 --- /dev/null +++ b/297/ops_codes.txt @@ -0,0 +1 @@ +Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Myotomie M. constrictor pharyngis mit Pharyngotomie[5-299.01 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] \ No newline at end of file diff --git a/297/patient_clinical_data.json b/297/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5b4e3b4e455d2402e6d4eb97a4edbbb28fd5eed1 --- /dev/null +++ b/297/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 67, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/297/patient_pathological_data.json b/297/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2df79e76c5e903be77183a44e6b8bf5b10ab8071 --- /dev/null +++ b/297/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "297", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 59, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/297/surgery_description.txt b/297/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f00aff3ea443aa6e8fee9681e6a8c5e59ffedd7d --- /dev/null +++ b/297/surgery_description.txt @@ -0,0 +1 @@ +Total laryngectomy, Bilateral neck dissection, PEG placement, Provox placement diff --git a/297/surgery_report.txt b/297/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..887eba7916c3d5cbb4afb9db58fb4c5ceac7ae13 --- /dev/null +++ b/297/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, the PEG is first applied by and . The PEG is inserted in the usual manner using the pull-through technique. The skin is then disinfected and infiltrated with local anesthetic containing adrenaline in the area of the right neck or the right half of the subsequent apron flap incision. Here, sharp dissection through the subcutaneous fatty tissue and the platysma with exposure of the front edge of the sternocleidomastoid muscle. This is exposed along its entire length. Then expose and skeletonize the digastric muscle and the omohyoid muscle. Now dissect the vascular nerve sheath starting caudally. Expose and protect the vagus nerve and the common carotid artery as well as the internal jugular vein up to ............................................... The large metastasis is then painstakingly dissected along the internal jugular vein to below the digastric muscle. Both the accessorius nerve and the hypoglossal nerve can be exposed and secured to the end. The metastasis can finally be dissected free from the vein and the entire resectate together with the neck dissection specimen of region II to V can be removed in toto. The last layers of tissue on the vein as well as a vein outlet supposedly located in the metastasis are examined using frozen section histology and reveal no tumor infiltration, so that a healthy dissection can be assumed. Therefore, the apron flap is widened on the left side and folded up to above the hyoid bone. This is followed by radical neck dissection on the left side. Here, the vascular nerve sheath is first exposed under the digastric muscle and distally at the level of the omohyoid muscle. The metastasis here encompasses the internal jugular vein and can thus just be separated from the common carotid artery and the bifurcation as well as from the internal carotid artery in a healthy layer. However, the hypoglossal nerve and the accessorius nerve cannot be preserved. The internal jugular vein is then removed caudally and cranially and the entire specimen, including the neck dissection section, is completely resected. The larynx is then released. The suprahyoid muscles are first removed up to the pre-epiglottic fat body on both sides. First release of the laryngeal skeleton on the left side. Dissection of the right thyroid lobe and ligation of the isthmus so that the right thyroid lobe can be folded laterally. Subsequently, separation of the muscular insertions of the constrictor pharyngis muscle from the thyroid cartilage. Release the piriform sinus. Same procedure on the opposite side. The upper trachea is then exposed on the first 5 tracheal clamps. Opening of the trachea between the 2nd and 3rd tracheal clasps and reintubation of the patient. The lingual epiglottis is then exposed submucosally up to its superior edge. There, the pharyngeal mucosa is incised and the epiglottis is turned ventrally. After releasing the epiglottis, one looks at the rather large tumor located on the left side in the area of the arytenoid region. This is first incised on the left side. The same is done on the right side. The larynx is then removed under the cricoid cartilage and dissected cranially. The tumor and the laryngectomy specimen are then removed in toto under visualization and the two pharyngeal incisions are joined together in the area of the esophageal entrance. During the subsequent inspection, the resectate appears to be somewhat closer to the right hypopharynx. Therefore, another resection is performed here, which is not sent for frozen section histology. Subsequently, marginal sections are taken from all sides of the remaining pharynx, all of which are found to be tumor-free by frozen section histology. Particularly in the caudal part of the pharynx with the transition to the esophagus, there is just enough mucosa left to allow primary closure to be performed. Subsequent myotomy of the constrictor pharyngis muscle. Implantation of the Provox voice prosthesis in the usual manner. Then resection of the 2 upper tracheal clips so that the trachea can then be drained directly. The pharyngeal suture is then applied. The first layer forms a continuous T-shaped Conley suture. The second layer above this is performed in a single button suture. Finally, Redon suction drains are placed on both sides. Folding back of the apron flap and multi-layer wound closure with completion of the mucocutaneous anastomosis in the area of the tracheostoma and reintubation of the patient onto a 10-gauge tracheostomy tube. End of the operation after sterile wound dressing and handover of the patient to anesthesia. Conclusion: Totae laryngectomy for a squamous cell carcinoma located mainly on the left side of the arytenoid region with primary wound closure. Radical neck dissection on the left side and selective neck dissection on the right. Primary voice rehabilitation by implantation of a Provox voice prosthesis and myotomy of the constrictor pharyngis muscle. PEG placement. Due to the pronounced metastasis, adjuvant therapy in the form of radiochemotherapy is certainly recommended. \ No newline at end of file diff --git a/298/InvasionFront_CD3_block12_x3_y2_patient298_0.json b/298/InvasionFront_CD3_block12_x3_y2_patient298_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7511f1bcb1269fa3455d9820d143a9c81dd2538e --- /dev/null +++ b/298/InvasionFront_CD3_block12_x3_y2_patient298_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12177.4, + "Centroid Y µm": 9728.7, + "Num Detections": 18698, + "Num Negative": 17483, + "Num Positive": 1215, + "Positive %": 6.498, + "Num Positive per mm^2": 551.74 + } +} \ No newline at end of file diff --git a/298/InvasionFront_CD3_block12_x4_y2_patient298_1.json b/298/InvasionFront_CD3_block12_x4_y2_patient298_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3fc9828d44be838fe5b28209c6a447463d2cf33a --- /dev/null +++ b/298/InvasionFront_CD3_block12_x4_y2_patient298_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14792.2, + "Centroid Y µm": 9969.7, + "Num Detections": 18960, + "Num Negative": 18321, + "Num Positive": 639, + "Positive %": 3.37, + "Num Positive per mm^2": 296.57 + } +} \ No newline at end of file diff --git a/298/InvasionFront_CD8_block12_x3_y2_patient298_0.json b/298/InvasionFront_CD8_block12_x3_y2_patient298_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2579d8bbd052c100174adb2dc28d66666b1c41b7 --- /dev/null +++ b/298/InvasionFront_CD8_block12_x3_y2_patient298_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11593.9, + "Centroid Y µm": 8570.5, + "Num Detections": 19483, + "Num Negative": 19096, + "Num Positive": 387, + "Positive %": 1.986, + "Num Positive per mm^2": 174.49 + } +} \ No newline at end of file diff --git a/298/InvasionFront_CD8_block12_x4_y2_patient298_1.json b/298/InvasionFront_CD8_block12_x4_y2_patient298_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c1d6cf88952b0e775b813709ffe248a3012b32f --- /dev/null +++ b/298/InvasionFront_CD8_block12_x4_y2_patient298_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14242.5, + "Centroid Y µm": 8520.5, + "Num Detections": 18197, + "Num Negative": 18010, + "Num Positive": 187, + "Positive %": 1.028, + "Num Positive per mm^2": 93.38 + } +} \ No newline at end of file diff --git a/298/TumorCenter_CD3_block12_x3_y2_patient298_0.json b/298/TumorCenter_CD3_block12_x3_y2_patient298_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6474eb9ff35e145cd2eae4621076204819ff4d52 --- /dev/null +++ b/298/TumorCenter_CD3_block12_x3_y2_patient298_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10894.2, + "Centroid Y µm": 4972.4, + "Num Detections": 20789, + "Num Negative": 19932, + "Num Positive": 857, + "Positive %": 4.122, + "Num Positive per mm^2": 355.54 + } +} \ No newline at end of file diff --git a/298/TumorCenter_CD3_block12_x4_y2_patient298_1.json b/298/TumorCenter_CD3_block12_x4_y2_patient298_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f5e0a6e2c37480f3ec4921350e3d488052f91535 --- /dev/null +++ b/298/TumorCenter_CD3_block12_x4_y2_patient298_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 4997.4, + "Num Detections": 17345, + "Num Negative": 16123, + "Num Positive": 1222, + "Positive %": 7.045, + "Num Positive per mm^2": 553.18 + } +} \ No newline at end of file diff --git a/298/TumorCenter_CD8_block12_x3_y2_patient298_0.json b/298/TumorCenter_CD8_block12_x3_y2_patient298_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8392c6ed863bb1f33dbfcd597e91d9ff798f702d --- /dev/null +++ b/298/TumorCenter_CD8_block12_x3_y2_patient298_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14542.3, + "Centroid Y µm": 14317.4, + "Num Detections": 21463, + "Num Negative": 21292, + "Num Positive": 171, + "Positive %": 0.7967, + "Num Positive per mm^2": 70.0 + } +} \ No newline at end of file diff --git a/298/TumorCenter_CD8_block12_x4_y2_patient298_1.json b/298/TumorCenter_CD8_block12_x4_y2_patient298_1.json new file mode 100644 index 0000000000000000000000000000000000000000..71831d386a4def81925558ad93e226d521d259c9 --- /dev/null +++ b/298/TumorCenter_CD8_block12_x4_y2_patient298_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 14542.3, + "Num Detections": 16528, + "Num Negative": 16118, + "Num Positive": 410, + "Positive %": 2.481, + "Num Positive per mm^2": 189.82 + } +} \ No newline at end of file diff --git a/298/history_text.txt b/298/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..cb6c261797a4dae9392df13e8dfd4b7fcc3babe5 --- /dev/null +++ b/298/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed oropharyngeal carcinoma on the left. CT showed deep infiltration of the ................... so that primary transcervical resection and flap coverage had to be planned. Radial flap not possible in the planning, therefore defect coverage planned as ALT. \ No newline at end of file diff --git a/298/icd_codes.txt b/298/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/298/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/298/ops_codes.txt b/298/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b7fcba801c2333b6cb9165b61c4fcd12414725a --- /dev/null +++ b/298/ops_codes.txt @@ -0,0 +1 @@ +Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit gestieltem regionalen Lappen[5-295.x2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Partielle Glossektomie transoral sonstige[5-251.0x ] Sonstige partielle Laryngektomie[5-302.x ] Gastrostomie perkutan-endoskopisch [PEG][5-431.2 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] \ No newline at end of file diff --git a/298/patient_clinical_data.json b/298/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e39fff36fdda2fc873ac9787fcecf7b2c258ab88 --- /dev/null +++ b/298/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 71, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/298/patient_pathological_data.json b/298/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..32164a38b88c353a291d7f57fd5461f842088db2 --- /dev/null +++ b/298/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "298", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/298/surgery_description.txt b/298/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f453901d84104cff47b269c5673ce74e499965b9 --- /dev/null +++ b/298/surgery_description.txt @@ -0,0 +1 @@ +Resection and flap coverage, Pedicled flap (Pectoralis major) diff --git a/298/surgery_report.txt b/298/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d31dcc2c37ef35203028897410faac443f00f83 --- /dev/null +++ b/298/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy and laryngoscopy: The exophytic tumor is seen in the tonsillar lobe area extending from the palatine arch down to the hypoharyngeal entrance, involving the base of the tongue, on the edge of the tongue on the left side, tumor extends medially over the vallecula and lingual epiglottis to just above the midline, here in the supraglottic area. Base of tongue palpatorily affected up to the midline. Indication for surgery with flap coverage confirmed. Now repositioning of the patient. Injection not possible due to the cardiologic situation. Start with extended radical neck dissection on the left: Typical skin incision in front of the sternocleidomastoid muscle. Exposure of the anterior border of the sternocleidomastoid muscle. This shows that the lymph node package has infiltrated the muscle in the middle and cranial area. The muscle is therefore removed cranially and caudally and also resected. Further dissection shows infiltration of the internal jugular vein, which is separated slightly below the exit of the inferior thyroid and ligated twice. However, the external jugular vein was preserved during dissection, and a supraclavicular vein and an additional outlet from the internal jugular vein, which could be used as a vascular anastomosis, can also be seen in the lower area. Further dissection shows infiltration of the lymph node conglomerate in the submandibular gland, hence resection of this gland and the caudal parotid pole as well as the digastric musculature. There is also infiltration of the external carotid artery. This must be placed just above the bulb and is supplied here by means of bypasses. The facial artery, lingual artery, superior thyroid artery and all other cranial ascending branches up to the superficial temporal artery must be resected and ligated. The external carotid artery is ligated twice cranially. It becomes apparent that the tumor is in contact with the primary tumor, so that per continuitatem growth at the level of the hyoid bone and in the area of the resected external carotid artery must be suspected. This is followed by repositioning for first transoral and then transcervical combined resection of the oropharyngeal carcinoma. First insertion of the tonsillar blocker from the transoral side, alternating with oral blockers. Tongue ligation. Tumor is incised on all sides with a safety margin of at least 1.5 cm to 2 cm. This involves resection of the palatal arch from the uvula to the left, all tissue up to the lower jaw, whereby the periosteum is pushed away from the lower jaw. Pterygoid muscles are resected per continuitatem through the wall. The internal carotid artery is checked from the side here. The posterior wall of the oropharynx is resected almost to the middle. The posterior half of the tongue is initially resected superficially and only later in the tongue base area beyond the midline. The mobilized specimen is finally pulled through transcervically and the mucosa is resected under visualization up to the piriform sinus entrance in the oropharyngeal side wall area. The entire vallecula, the epiglottis and the base of the tongue are resected medially until a residual portion of approx. 25 % remains. This is still well supplied with blood. On the opposite side, the more cranial base of the tongue is still preserved and the caudal part is resected together with the vallecula. Resection ends at the beginning of the supraglottic area after removal of the epiglottis. The entire preparation and a marginal sample from the palatal arch and from the area of the base of the tongue and vallecula on the right side are sent in. Here the specimen on all sides in healthy tissue, including basal, cranial and caudal as well as the marginal specimens are also tumor-free. The intraoperative situation is therefore R0. Neck dissection now follows on the right side. Skin incision in the typical manner, dissection of the fat lymph node package of the sternocleidomastoid muscle. The lymph node is adherent to the facial vein and internal jugular vein, but can be dissected here while preserving the vessels. Exposure of the omohyoid muscle and digastric muscle. Final exposure of the cervical vascular sheath, vagus nerve, accessorius nerve and hypoglossus. Development of the dorsal neck preparation while preserving the branches of the cervical plexus. Subsequent development of the anterior neck preparation. The result is a neck dissection level II to V on the right side and Ib to V on the left side. Now the tracheostoma is created in the typical manner. Longitudinal section between the neck sections. Depiction of the trachea. Entering the 2nd/3rd intercartilaginous space. Small, broadly pedunculated Björk flap. This is epithelized in a typical manner. Re-intubation and insertion of laryngectomy tube. The defect is then covered using a pectoralis major flap: The planned defect coverage using a free flap proves to be unfeasible intraoperatively. The remaining residual stump of the left external carotid artery shows clear calcific plaques on palpation. If the patient has had an apoplexy, clamping without an increased risk of reapoplexy does not make sense here. Venous anastomosis on the left via the external jugular vein is possible. However, the arterial connection on the same side is missing. The evaluation of the vessels in the supraclavicular region also shows no corresponding possibilities for a vascular connection. ........................ The right side shows an external carotid artery, which is too short for a primary anastomosis of the ALT and also too small for a possible interposition. The first outlet appears to be a thyro-lingual artery. The transection of the lingual artery is not possible due to the previous resection of the opposite side. This also rules out the external carotid artery as an option for arterial anastomosis. The only remaining option is to use a pectoralis major flap to cover the defect. The patient is therefore repositioned. Sterile covering of the entire thoracic area up to the upper abdomen. After measuring the length of the flap pedicle and the size of the skin island, the island is marked according to the extent and shape of the defect. A subfascial skin bridge is then created from the neck area to the lower end of the marked deltopectoral flap, which is not lifted distally. Then expose the pectoralis major muscle and expose the vascular pedicle. The flap is then cut to the appropriate size and length and securing sutures are placed. The flap has a length of 11 1/2 cm and a width of 6 cm in the distal area and 9 cm in the proximal area. Successive development of the flap on its muscle pedicle including the vascular nerve bundle up to the clavicle. The flap is then pulled under the skin bridge. Insertion of the flap into the oropharyngeal defect. The flap is first sutured cranially, including the palatal arch. Caudally, the flap extends to the piriform sinus entrance, it then swivels towards the supraglottic area. The skin island is sutured directly supraglottically to the thyroid cartilage. Complete low-tension closure of the defect. Subsequent layer-by-layer closure of the thoracic wound after skin mobilization, which is successful without tension. Skin closure after extensive hemostasis with insertion of 2 Redon drains. On the left cervical side, tension-free closure over the pedicle after radical neck dissection with insertion of 2 Redon drains. On the right, the wound is closed with the insertion of a Redon drain. An 8-gauge tracheostomy tube is inserted into the tracheostoma. The patient is admitted to the intensive care unit postoperatively and ventilated. Antibiotic treatment, which was started intraoperatively, is continued with Unacid for one week. In the case of circulatory instability or previous cardiological illness and due to the use of Plavix or previous heparinization, the operation was characterized by a diffuse bleeding tendency in the advanced course. Factor replacement and preservatives were necessary. Post-operative nutrition via the inserted PEG for 10 days, followed by gruel and then, if necessary, diet reconstruction. Overall cT4a cN2c findings and continuous growth on the left. Postoperative RCT recommended if the patient's condition permits. \ No newline at end of file diff --git a/299/InvasionFront_CD3_block5_x5_y10_patient299_0.json b/299/InvasionFront_CD3_block5_x5_y10_patient299_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9cd73c13961b975a7eb47686685deab9aec089d5 --- /dev/null +++ b/299/InvasionFront_CD3_block5_x5_y10_patient299_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 25561.5, + "Num Detections": 25911, + "Num Negative": 23723, + "Num Positive": 2188, + "Positive %": 8.444, + "Num Positive per mm^2": 844.11 + } +} \ No newline at end of file diff --git a/299/InvasionFront_CD3_block5_x6_y10_patient299_1.json b/299/InvasionFront_CD3_block5_x6_y10_patient299_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5ffad04b69b2708ff0d3ae166a3f188b9892e1e1 --- /dev/null +++ b/299/InvasionFront_CD3_block5_x6_y10_patient299_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 25561.5, + "Num Detections": 27604, + "Num Negative": 25620, + "Num Positive": 1984, + "Positive %": 7.187, + "Num Positive per mm^2": 766.89 + } +} \ No newline at end of file diff --git a/299/InvasionFront_CD8_block5_x5_y8_patient299_0.json b/299/InvasionFront_CD8_block5_x5_y8_patient299_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba3e602f57746e7c0b10a537465d0aea799f7580 --- /dev/null +++ b/299/InvasionFront_CD8_block5_x5_y8_patient299_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 20289.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/299/InvasionFront_CD8_block5_x6_y8_patient299_1.json b/299/InvasionFront_CD8_block5_x6_y8_patient299_1.json new file mode 100644 index 0000000000000000000000000000000000000000..169824e0c7a5b7cc999c2ed7b7064fd67f3f56b4 --- /dev/null +++ b/299/InvasionFront_CD8_block5_x6_y8_patient299_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18640.1, + "Centroid Y µm": 20264.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/299/TumorCenter_CD3_block5_x5_y8_patient299_0.json b/299/TumorCenter_CD3_block5_x5_y8_patient299_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d78929a5313f2683a43d0d534fa2e01f2b82aeeb --- /dev/null +++ b/299/TumorCenter_CD3_block5_x5_y8_patient299_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16566.2, + "Centroid Y µm": 20389.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/299/TumorCenter_CD3_block5_x6_y8_patient299_1.json b/299/TumorCenter_CD3_block5_x6_y8_patient299_1.json new file mode 100644 index 0000000000000000000000000000000000000000..46a2bae753d3d04245f6b95353c0ea6993d7c2b6 --- /dev/null +++ b/299/TumorCenter_CD3_block5_x6_y8_patient299_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 20639.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/299/TumorCenter_CD8_block5_x5_y8_patient299_0.json b/299/TumorCenter_CD8_block5_x5_y8_patient299_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8c6743f7c1935f8d0ca8361e9c53bace7e57f4b6 --- /dev/null +++ b/299/TumorCenter_CD8_block5_x5_y8_patient299_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 20139.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/299/TumorCenter_CD8_block5_x6_y8_patient299_1.json b/299/TumorCenter_CD8_block5_x6_y8_patient299_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf30a2fa7c841434dff51e6bda0a363ebef8a430 --- /dev/null +++ b/299/TumorCenter_CD8_block5_x6_y8_patient299_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 20189.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/299/history_text.txt b/299/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..68f5a384f741bc8083cf050dfbb2e69006969be1 --- /dev/null +++ b/299/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed small carcinoma of the base of the tongue on the left side. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/299/icd_codes.txt b/299/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/299/ops_codes.txt b/299/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ca61390ac9875e678c6cb50327ab9436efb2b82 --- /dev/null +++ b/299/ops_codes.txt @@ -0,0 +1 @@ +Inzision Zungengrund[5-250.x ] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Temporäre Tracheotomie[5-311.0 ] Anwendung eines komplexen OP-Roboters (Zusatzkode)[5-987.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/299/patient_clinical_data.json b/299/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..301dd6fdda4d67cc16f1cf59261cd3f061faafbd --- /dev/null +++ b/299/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 39, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/299/patient_pathological_data.json b/299/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8102e3457fd995e136eb2315ea552044ceebd7cb --- /dev/null +++ b/299/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "299", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/299/surgery_description.txt b/299/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d63332d300f6e375f753296b3847d8abc0477dbe --- /dev/null +++ b/299/surgery_description.txt @@ -0,0 +1 @@ +Robot-assisted tumor resection, Tracheotomy diff --git a/299/surgery_report.txt b/299/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3adca82f70cc8cc121d170598d137af9ad17e240 --- /dev/null +++ b/299/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia and intubation with a laser tube transorally via the anesthesia colleagues. Entry with the Kleinsasser tube and identification of the tumor. This is very difficult as the tumor has been reduced in size by the biopsy and only a scarred area is visible. A sample is therefore taken from this area to ensure that the tumor is resected correctly. The frozen section of this sample shows at least a carinoma in situ and suspected invasive carcinoma matching the preliminary histology and after consultation with the pathology department it is the site described. Therefore, insertion of the DaVinci oral retractor. Insertion of camera and dissection arm and dissector arm. The tumor is now robotically sectioned using monopolar coagulation and the specimen is thread-marked for the frozen section. In the frozen section, there is still invasive tumor in the basal/caudal margin. For this reason, a large resection is made here, thread-marked and also sent to the frozen section. Neither carcinoma in situ nor invasive carcinoma can now be detected at the basal and mucosal margins remote from the tumor, i.e. a definitive R0 situation. Moderate bleeding occurs during the post-resection, which is monopolar coagulated and thus stopped. Due to the relatively large wound area at the base of the tongue, a protective tracheotomy must be performed by . Skin incision below the cricoid cartilage for this. Dissection down to the trachea. Cut through the thyroid isthmus and enter the trachea between the second and third tracheal cartilage. Creation of a visor tracheotomy. Re-intubation to an 8 mm tracheal cannula and completion of the procedure without complications. The patient goes to the intensive care unit awake for monitoring. \ No newline at end of file diff --git a/300/InvasionFront_CD3_block20_x1_y1_patient300_0.json b/300/InvasionFront_CD3_block20_x1_y1_patient300_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9ae5b547bb41a340bef21557778e88d3654952ee --- /dev/null +++ b/300/InvasionFront_CD3_block20_x1_y1_patient300_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5246.0, + "Centroid Y µm": 3740.8, + "Num Detections": 16175, + "Num Negative": 15982, + "Num Positive": 193, + "Positive %": 1.193, + "Num Positive per mm^2": 100.02 + } +} \ No newline at end of file diff --git a/300/InvasionFront_CD3_block20_x2_y1_patient300_1.json b/300/InvasionFront_CD3_block20_x2_y1_patient300_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ccd8f6511280ca49edcc497d63ca15a78da6813d --- /dev/null +++ b/300/InvasionFront_CD3_block20_x2_y1_patient300_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7826.4, + "Centroid Y µm": 3142.8, + "Num Detections": 16923, + "Num Negative": 16606, + "Num Positive": 317, + "Positive %": 1.873, + "Num Positive per mm^2": 161.47 + } +} \ No newline at end of file diff --git a/300/InvasionFront_CD8_block20_x1_y1_patient300_0.json b/300/InvasionFront_CD8_block20_x1_y1_patient300_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d763f946d4a163f90b785665d1bbe1d991aa697c --- /dev/null +++ b/300/InvasionFront_CD8_block20_x1_y1_patient300_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3077.7, + "Centroid Y µm": 3531.7, + "Num Detections": 15174, + "Num Negative": 15097, + "Num Positive": 77, + "Positive %": 0.5074, + "Num Positive per mm^2": 40.15 + } +} \ No newline at end of file diff --git a/300/InvasionFront_CD8_block20_x2_y1_patient300_1.json b/300/InvasionFront_CD8_block20_x2_y1_patient300_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2da967c7c129634f38d042a1e5db68e53ef028be --- /dev/null +++ b/300/InvasionFront_CD8_block20_x2_y1_patient300_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5788.4, + "Centroid Y µm": 3080.3, + "Num Detections": 16960, + "Num Negative": 16854, + "Num Positive": 106, + "Positive %": 0.625, + "Num Positive per mm^2": 53.66 + } +} \ No newline at end of file diff --git a/300/TumorCenter_CD3_block20_x1_y1_patient300_0.json b/300/TumorCenter_CD3_block20_x1_y1_patient300_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eb9cda33e8803af9e1c1d23db2b32526c5aed599 --- /dev/null +++ b/300/TumorCenter_CD3_block20_x1_y1_patient300_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4140.7, + "Centroid Y µm": 2367.6, + "Num Detections": 10306, + "Num Negative": 10210, + "Num Positive": 96, + "Positive %": 0.9315, + "Num Positive per mm^2": 63.29 + } +} \ No newline at end of file diff --git a/300/TumorCenter_CD3_block20_x2_y1_patient300_1.json b/300/TumorCenter_CD3_block20_x2_y1_patient300_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3e98344925679b1a19a7b7c9acde5e52e58c7783 --- /dev/null +++ b/300/TumorCenter_CD3_block20_x2_y1_patient300_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6741.2, + "Centroid Y µm": 2779.4, + "Num Detections": 11765, + "Num Negative": 11751, + "Num Positive": 14, + "Positive %": 0.119, + "Num Positive per mm^2": 7.819 + } +} \ No newline at end of file diff --git a/300/TumorCenter_CD8_block20_x1_y1_patient300_0.json b/300/TumorCenter_CD8_block20_x1_y1_patient300_0.json new file mode 100644 index 0000000000000000000000000000000000000000..70e3bece0fb4e7bfa808ea1ff75e4b6cfa50ee3a --- /dev/null +++ b/300/TumorCenter_CD8_block20_x1_y1_patient300_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3073.4, + "Centroid Y µm": 3198.3, + "Num Detections": 10129, + "Num Negative": 10059, + "Num Positive": 70, + "Positive %": 0.6911, + "Num Positive per mm^2": 48.74 + } +} \ No newline at end of file diff --git a/300/TumorCenter_CD8_block20_x2_y1_patient300_1.json b/300/TumorCenter_CD8_block20_x2_y1_patient300_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4c65364595a49a389c23e7d507c17caa4091fcd0 --- /dev/null +++ b/300/TumorCenter_CD8_block20_x2_y1_patient300_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5747.0, + "Centroid Y µm": 3173.3, + "Num Detections": 13865, + "Num Negative": 13860, + "Num Positive": 5, + "Positive %": 0.0361, + "Num Positive per mm^2": 3.139 + } +} \ No newline at end of file diff --git a/300/history_text.txt b/300/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/300/icd_codes.txt b/300/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15cdf3cedbb267117d620058bfef3b6f5d6fd43f --- /dev/null +++ b/300/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/300/ops_codes.txt b/300/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b36ec3511b613d79f1b58048e3966b78f096089a --- /dev/null +++ b/300/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.x1 ] Permanente Tracheotomie[5-312.0 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] \ No newline at end of file diff --git a/300/patient_clinical_data.json b/300/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..74b94d8058f58602d508cc545409b29fd1f78e80 --- /dev/null +++ b/300/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 40, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/300/patient_pathological_data.json b/300/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..38d151af339c83c9286e2d15110e4394e168e769 --- /dev/null +++ b/300/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "300", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/300/surgery_description.txt b/300/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..11f0e0f3e6c1b201f1eed51cabac893186afe5d8 --- /dev/null +++ b/300/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, PEG placement, Modified radical bilateral Neck Dissection, Laryngoscopy diff --git a/300/surgery_report.txt b/300/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..395ceb6522e716c051cf123b0b6fc9489c49f00c --- /dev/null +++ b/300/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues. Entering with 0° optics and inspection of the tumor. The tumor is located on the left side, completely infiltrating the vocal folds. Pass the tumor region and look subglottically. Here, there is a slight extension in the subglottic slope. The subglottis itself and the trachea are tumor-free. Intubation by the anesthesia colleagues transnasally. Entry with the small bore tube and re-inspection of the tumor region. It is clear that the tumor extends very far caudally in the area of the arytenoid cartilage. A visible mucosal infiltration extends as far as the arytenoid cartilage. The arytenoid cartilage itself is distended and thickened, suggesting a submucosal infiltration. Decision to perform a laryngectomy due to the age and extent of the tumor. Esophageal entrance and piriform sinus on both sides are free. Sterile washing and covering after injection. Creation of an apron flap in the usual manner. Start with neck dissection on the left side. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Release of the neck levels IIa to Va while sparing the plexus branches. There are several spherical and suspicious masses on all sides, especially in levels II and III. Exposure of the hyoid bone. Detachment of the hyoid bone on the left side. Detachment of the cervical vascular sheath from the larynx and pharyngeal region. Detachment of the thyroid gland. Exposure of the upper laryngeal bundle. Coagulation of the upper laryngeal bundle and transection of the upper laryngeal bundle. Turning to the opposite side. Exposure of the sternocleidomastoid muscle, submandibular gland, omohyoid muscle and digastric muscle. Clearing out the neck levels IIa to Va. There are several suspicious lymph nodes, especially in levels IIa and b. Exposure of the hyoid bone here as well. Release of the hyoid bone. Removal of the hyoid bone. Exposure of the superior laryngeal nerve, A. and V. laryngea. Separation of these. Detachment of the cervical vascular sheath from the larynx and pharyngeal region and detachment of the thyroid gland. Detachment of the infrahyal musculature and the laryngeal musculature. Performing the tracheotomy between the 2nd and 3rd tracheal cartilage. Transfer intubation to a laryngectomy tube. Start skeletonization of the larynx on the right side. Release and push off the piriform sinus, same procedure on the left side. Here the piriform sinus can only be partially released, as this is the tumor side. Enter the pharynx at the level of the epiglottis from the right side. Pull out the epiglottis through the pharyngotomy and incise the mucosa along the edge of the epiglottis up to the arytenoid region. Here, detachment of the mucosa caudally from the arytenoid cartilage. Detachment and separation of the larynx. In the area of the piriform sinus on the left side, the mucosa and soft tissue are resected again and a marginal sample is taken. Unfortunately, this marginal sample still shows carcinoma. Therefore, a large resection and another marginal sample are taken. This marginal sample is ultimately tumor-free. Creation of an esophagotracheal fistula and insertion of a size 10 Provox prosthesis (Provox 1). Perform the pharyngeal suture in a three-layered manner as usual. Reduction of the insertions of the sternocleidomastoid muscle and insertion of Redon drains. Incision of the skin in the area of the tracheostoma and two-layer wound closure. The operation is completed without complications. The patient goes to the intensive care unit in an awake state. Please continue antibiotics for 24 hours. The patient is fed for 10 days via the PEG tube inserted during the operation (no problems with good diaphanoscopy). \ No newline at end of file diff --git a/301/InvasionFront_CD3_block22_x3_y2_patient301_0.json b/301/InvasionFront_CD3_block22_x3_y2_patient301_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ff95026a45a5b18724e78efe68ab51c535599efe --- /dev/null +++ b/301/InvasionFront_CD3_block22_x3_y2_patient301_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12218.5, + "Centroid Y µm": 16441.3, + "Num Detections": 19703, + "Num Negative": 19194, + "Num Positive": 509, + "Positive %": 2.583, + "Num Positive per mm^2": 209.46 + } +} \ No newline at end of file diff --git a/301/InvasionFront_CD3_block22_x4_y2_patient301_1.json b/301/InvasionFront_CD3_block22_x4_y2_patient301_1.json new file mode 100644 index 0000000000000000000000000000000000000000..324a1776028914cb4264c84097306edadf34c66b --- /dev/null +++ b/301/InvasionFront_CD3_block22_x4_y2_patient301_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14842.1, + "Centroid Y µm": 16516.3, + "Num Detections": 20660, + "Num Negative": 19660, + "Num Positive": 1000, + "Positive %": 4.84, + "Num Positive per mm^2": 418.31 + } +} \ No newline at end of file diff --git a/301/InvasionFront_CD8_block22_x3_y2_patient301_0.json b/301/InvasionFront_CD8_block22_x3_y2_patient301_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08c137459d0b9aae92064d1839affe8e8142bec7 --- /dev/null +++ b/301/InvasionFront_CD8_block22_x3_y2_patient301_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 5322.2, + "Num Detections": 18217, + "Num Negative": 18194, + "Num Positive": 23, + "Positive %": 0.1263, + "Num Positive per mm^2": 10.01 + } +} \ No newline at end of file diff --git a/301/InvasionFront_CD8_block22_x4_y2_patient301_1.json b/301/InvasionFront_CD8_block22_x4_y2_patient301_1.json new file mode 100644 index 0000000000000000000000000000000000000000..32981a39b372ee0012fbfbf6325002550d423779 --- /dev/null +++ b/301/InvasionFront_CD8_block22_x4_y2_patient301_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 5197.2, + "Num Detections": 19939, + "Num Negative": 19853, + "Num Positive": 86, + "Positive %": 0.4313, + "Num Positive per mm^2": 37.48 + } +} \ No newline at end of file diff --git a/301/TumorCenter_CD3_block22_x3_y2_patient301_0.json b/301/TumorCenter_CD3_block22_x3_y2_patient301_0.json new file mode 100644 index 0000000000000000000000000000000000000000..48cefaa25ae2d411b03d64a1d51857b110b92388 --- /dev/null +++ b/301/TumorCenter_CD3_block22_x3_y2_patient301_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12043.6, + "Centroid Y µm": 5996.8, + "Num Detections": 19825, + "Num Negative": 19601, + "Num Positive": 224, + "Positive %": 1.13, + "Num Positive per mm^2": 96.74 + } +} \ No newline at end of file diff --git a/301/TumorCenter_CD3_block22_x4_y2_patient301_1.json b/301/TumorCenter_CD3_block22_x4_y2_patient301_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9c3972833318dd9e50404f72518b05e3caf6259b --- /dev/null +++ b/301/TumorCenter_CD3_block22_x4_y2_patient301_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14567.3, + "Centroid Y µm": 6096.8, + "Num Detections": 20112, + "Num Negative": 19940, + "Num Positive": 172, + "Positive %": 0.8552, + "Num Positive per mm^2": 72.92 + } +} \ No newline at end of file diff --git a/301/TumorCenter_CD8_block22_x3_y2_patient301_0.json b/301/TumorCenter_CD8_block22_x3_y2_patient301_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3281ca8bf1eb7f1ae2194a16dd9f14c4d62930a6 --- /dev/null +++ b/301/TumorCenter_CD8_block22_x3_y2_patient301_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 14992.1, + "Num Detections": 19969, + "Num Negative": 19929, + "Num Positive": 40, + "Positive %": 0.2003, + "Num Positive per mm^2": 17.39 + } +} \ No newline at end of file diff --git a/301/TumorCenter_CD8_block22_x4_y2_patient301_1.json b/301/TumorCenter_CD8_block22_x4_y2_patient301_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f67d7e83999fca9c91b15d55247f88e9600dd95 --- /dev/null +++ b/301/TumorCenter_CD8_block22_x4_y2_patient301_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16866.1, + "Centroid Y µm": 15117.0, + "Num Detections": 18774, + "Num Negative": 18704, + "Num Positive": 70, + "Positive %": 0.3729, + "Num Positive per mm^2": 29.95 + } +} \ No newline at end of file diff --git a/301/history_text.txt b/301/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8f8f3d38d175e2a2b0ac6d198b3c52473b0ba1b4 --- /dev/null +++ b/301/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed poorly differentiated carcinoma in the area of the supraglottis with transition to the pharyngeal side wall on the right. Indication for the above-mentioned operation. \ No newline at end of file diff --git a/301/icd_codes.txt b/301/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/301/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/301/ops_codes.txt b/301/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..61e367c27437d7b0693168c689e238285f0445ad --- /dev/null +++ b/301/ops_codes.txt @@ -0,0 +1 @@ +Andere partielle Laryngektomie: Partielle Larynx-Pharynx-Resektion[5-302.4 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, erweitert: 4 Regionen[5-403.30 R] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 4 Regionen[5-403.20 B] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] \ No newline at end of file diff --git a/301/patient_clinical_data.json b/301/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b049a1c65d86982603e94eb503e573e873e55499 --- /dev/null +++ b/301/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/301/patient_pathological_data.json b/301/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..025d4122a763b91b9e3a0027c08e4cb6f0ef2352 --- /dev/null +++ b/301/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "301", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 6.0, + "number_of_resected_lymph_nodes": 50, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/301/surgery_description.txt b/301/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e874ff92f2823933d4bdc0417a683e0d30ca387b --- /dev/null +++ b/301/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection according to Alonso, Right pharyngeal partial resection, Bilateral neck dissection, Tracheostomy, PEG placement, Endoscopy diff --git a/301/surgery_report.txt b/301/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..700d6281630f2c15f294cbd43b9d76a36d6045e2 --- /dev/null +++ b/301/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy and laryngoscopy: insertion of the Kleinsasser tube of medium size. The clearly exophytic tumor can be seen, which has consumed about 75% of the epiglottis, the tumor runs over the arytenoid fold onto the medial anterior and lateral wall in the area of the piriform sinus or pharyngeal side wall. Tumor does not appear to be optimally displaceable, particularly in the area of the vallecula, where infiltration is also evident; deeper growth is likely in the case of ulceration. The base of the tongue is not affected. In conjunction with the CT, where an infiltration of the pre-epiglottic space up to the hyoid bone is described and the proximity of the tumor to vessels, lymph node metastases. Decision to proceed primarily from the outside after discussing the findings with . PEG insertion (, ): Insertion of the esophagoscope in a typical manner. Advance into the stomach, where a 9-bore abdominal wall tube is inserted in the typical manner after a diaphanoscopy has been performed. Fixation of this. Then sterile draping, injection of a total of 12 ml xylocaine 1% with arenalin in the area of the neck on both sides. Then marking of a platysmal flap for possible defect coverage in case of pharyngeal wall infestation. Then elevation of an apron flap subplatysmal including the platysmal flap to be elevated. The platysmal flap is dissected in its skin island and lifted from the neck skin, including the subcutaneous tissue. However, dissection is not carried out up to the chin; this should only be done during the final flap suture. Dissection of the apron flap up to the level of the hyoid bone and submandibular gland on both sides. This is followed by radical neck dissection on the right: a large lymph node package is seen on the right. This is difficult to separate from the sternocleidomastoid muscle, so that the muscle is partially resected here. However, an actual infiltration is not recognizable. Depiction of the digastric muscle, omohyoid muscle. Depiction of the internal jugular vein. This appears clearly infiltrated after dissection of some lymph nodes in the middle area. Exposure of the vagus nerve, accessorius nerve and internal and external carotid artery. Depiction of the hypoglossal nerve. This can be dissected away from the lymph node conglomerate with some effort. Infiltrated internal jugular vein is resected in the middle area and double ligated cranially and caudally. Then develop the entire lymph node conglomerate together with the dorsal neck preparation, whereby some branches of the cervical plexus are also embedded in the conglomerate and must therefore also be resected. However, the most important branches including the phrenic nerve can be preserved. Subsequently, development of the anterior neck preparation with ligation of the superior thyroid artery. Then modified radical neck dissection on the left: Exposure of the omohyoid and digastric muscles as on the opposite side. Inclusion of the submandibular gland capsule as on the opposite side. Dorsal neck preparation is developed with exposure of the internal jugular vein, carotid artery, vagus nerve and accessorius nerve. Removal is performed while preserving all cervical plexus structures. Subsequent development of the anterior neck preparation as on the opposite side. The superior thyroid artery is preserved. The hypoglossal nerve is also exposed and preserved. Then tumor resection: separation of the suprahyoid muscles from the right to the paramedian left. Exposure of hyoid bone. Exposure of ..................... superior. Detachment of the constrictor pharyngis muscle. All soft tissue behind the hyoid bone up to the larynx is also resected. Entry into the left paramedian larynx. Exposure of the epiglottis. After cutting around the tumor with a safety margin of at least 1-1.5 cm on all sides. Part of the left pharyngeal wall up to the middle of the lateral wall and the entire supraglottic area including both aryepiglottic folds are removed, leaving the thyroid cartilage intact. Vallecula and caudalmost parts of the base of the tongue are also resected. Tumor clearly removed in healthy tissue. Tumor is thread-marked. Marginal samples are taken from the arytenoid region as well as a resection in the tongue base region and a marginal sample in the tongue base region. The marginal samples and the marked tumor specimen are sent for frozen section diagnosis. Tumor in healthy tissue removed at the preoparate, marginal samples also tumor-free. Thus R0 resection. This is followed by complete irrigation of the entire wound area with H202 and Ringer's solution and careful hemostasis. The lingual artery is prophylactically ligated on the right side and severed. The lingual artery and superior thyroid artery on the tumor side are ligated and severed. The superior laryngeal nerve is preserved on both sides. Reconstruction as after Alonso resection. The posterior dorsal pharyngeal wall areas are adapted on the left and especially on the right using 3.0 single-button Vircyl sutures so that the defect remains towards the thyroid cartilage. The piriform sinus entrance is preserved. The arytenoid cartilage is exposed on the right side. Soft tissue largely removed up to the thyroid cartilage towards the front. The thyroid cartilage is then sutured with several Vicryl 0 sutures so that the thyroid cartilage comes to lie under the hyoid bone. This ensures stable and complete closure of the defect. The infrahyoid musculature is then sutured back to the hyoid bone. Before the tumor resection, a tracheostoma was also created. Here, the thyroid isthmus was exposed in a typical manner, passed underneath, clamped and supplied by means of stab ligatures. A Björk flap similar to a virsier flap was then created and epithelized in the 2nd/3rd intercartilaginous space. This was followed by reintubation and insertion of a laryngectomy tube. The wound area was then irrigated again with H202 and Ringer's solution and careful hemostasis was performed. The wound was then closed in layers with epithelialization of the tracheostoma and re-suturing of the skin island of the platysmal flap. A Redon drain was inserted on both sides. Finally, reintubation and insertion of a 7-gauge tracheostomy tube. The patient received Unacid 3 g i.v. intraoperatively. Please continue this antibiotic treatment for one week. Please feed patient via PEG for 7-10 days. Afterwards, if necessary, gruel swallowing and diet build-up. Patient goes to the intensive care unit for postoperative monitoring. \ No newline at end of file diff --git a/302/InvasionFront_CD3_block22_x3_y5_patient302_0.json b/302/InvasionFront_CD3_block22_x3_y5_patient302_0.json new file mode 100644 index 0000000000000000000000000000000000000000..05ab0935cb0ff2656bc8a337dfa1cb00f69bbe3d --- /dev/null +++ b/302/InvasionFront_CD3_block22_x3_y5_patient302_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12093.6, + "Centroid Y µm": 24012.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/302/InvasionFront_CD3_block22_x4_y5_patient302_1.json b/302/InvasionFront_CD3_block22_x4_y5_patient302_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3e0f3cafd1b363005acfeb85d347c6731ec828ab --- /dev/null +++ b/302/InvasionFront_CD3_block22_x4_y5_patient302_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14617.3, + "Centroid Y µm": 24062.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/302/InvasionFront_CD8_block22_x3_y5_patient302_0.json b/302/InvasionFront_CD8_block22_x3_y5_patient302_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dee4e4d34c52fe5797c9eff86cfd79a0b4957710 --- /dev/null +++ b/302/InvasionFront_CD8_block22_x3_y5_patient302_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14279.9, + "Centroid Y µm": 12580.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/302/InvasionFront_CD8_block22_x4_y5_patient302_1.json b/302/InvasionFront_CD8_block22_x4_y5_patient302_1.json new file mode 100644 index 0000000000000000000000000000000000000000..370d1128f70ac7328d5ef69f671c7d2b048e9ed0 --- /dev/null +++ b/302/InvasionFront_CD8_block22_x4_y5_patient302_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16653.7, + "Centroid Y µm": 12455.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/302/TumorCenter_CD3_block22_x3_y5_patient302_0.json b/302/TumorCenter_CD3_block22_x3_y5_patient302_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4972ee7f90aa47b96d5c1f7103cabc5b191a87cc --- /dev/null +++ b/302/TumorCenter_CD3_block22_x3_y5_patient302_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11818.7, + "Centroid Y µm": 13093.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/302/TumorCenter_CD3_block22_x4_y5_patient302_1.json b/302/TumorCenter_CD3_block22_x4_y5_patient302_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e13db5ab6c13529e7515a8c39cb90605c672f6bf --- /dev/null +++ b/302/TumorCenter_CD3_block22_x4_y5_patient302_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14230.0, + "Centroid Y µm": 13180.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/302/TumorCenter_CD8_block22_x3_y5_patient302_0.json b/302/TumorCenter_CD8_block22_x3_y5_patient302_0.json new file mode 100644 index 0000000000000000000000000000000000000000..af4fcaab4bdd23c607481f485126d00c166cc16f --- /dev/null +++ b/302/TumorCenter_CD8_block22_x3_y5_patient302_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 22038.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/302/TumorCenter_CD8_block22_x4_y5_patient302_1.json b/302/TumorCenter_CD8_block22_x4_y5_patient302_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6e500d2fe3a86a51a438f14beb6fb884368f282f --- /dev/null +++ b/302/TumorCenter_CD8_block22_x4_y5_patient302_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 22113.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/302/history_text.txt b/302/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a59d41c6794dba94585a08129e657e6035f60d0 --- /dev/null +++ b/302/history_text.txt @@ -0,0 +1 @@ +The patient has extensive hypopharyngeal/laryngeal carcinoma on the left side, which is why the patient initially received induction chemotherapy. When the tumor growth was insufficiently reduced both clinically and on PET-CT, a laryngectomy was indicated. \ No newline at end of file diff --git a/302/icd_codes.txt b/302/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8eb6cd7fac5c3b99c69823658dd38a1c2ee7589f --- /dev/null +++ b/302/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 L] \ No newline at end of file diff --git a/302/ops_codes.txt b/302/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aeb5e4e8c477f864808e7eeef900b3529c2eea5e --- /dev/null +++ b/302/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] \ No newline at end of file diff --git a/302/patient_clinical_data.json b/302/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e3e4cd3becc55a15d7376b9d2eb3d2ffb60926f5 --- /dev/null +++ b/302/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 57, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin + docetaxel", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/302/patient_pathological_data.json b/302/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d3faf919fc56b488077474514948a8eae17deac5 --- /dev/null +++ b/302/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "302", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 25.0 +} \ No newline at end of file diff --git a/302/surgery_description.txt b/302/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1127e5e9bbd5bb28d3bfb119a54aef0ea5adcb6b --- /dev/null +++ b/302/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Nasogastric feeding tube diff --git a/302/surgery_report.txt b/302/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..95526b96b1f51fab5bf74899e5873f2c7bf2120a --- /dev/null +++ b/302/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. First placement of the nasogastric feeding tube. Then injection of local anesthetic with adrenaline and preparation of an apron flap. Dissection of the anterior border of the sternocleidomastoid muscle on both sides. First expose the cervical vascular sheath on the right side. The venous vessels in particular are extremely fragile. There is therefore a greatly increased tendency to bleed and the surgical conditions are very difficult. First dissection of the lateral neck preparation. Tearing of the internal jugular vein, which must be sutured over. The vessel can thus be preserved in its continuity. Dissection of the accessorius nerve. Displacement to the cranial side and re-embedding of the nerve at the end of the operation in the sense of neurolysis. The same procedure is used for the vagus nerve, but it is moved medially. Re-embedding of the nerve in the sense of a neurolysis. Same procedure for the hypoglossal nerve. Displacement to the cranial side and at the end of the operation re-embedding of the hypoglossal nerve in the sense of a neurolysis. Finally, dissection of the entire neck preparation of levels Ib, II, III, IV and V. Subsequent separation of the upper pole of the thyroid gland from the trachea and the laryngeal skeleton. Exposure of the hyoid bone. Transition to neck dissection on the left side. This shows a lymph node conglomerate in the area of the venous angle. Caudal exposure of the cervical vascular sheath. Here, too, the situation is the same as on the other side of the neck. With very fragile vessels, there is a significantly increased tendency to bleed here. The preparation conditions are also very difficult here. First attempt at long-distance dissection of the cervical vascular sheath. However, it then becomes apparent that the conglomerate is firmly attached to the venous angle and cannot be separated. Therefore, first expose the internal jugular vein cranially and caudally. This is first looped here. Dissect caudally and separate the vein. Stitch around the distal vein stump. Dissection on the common carotid artery. Dissection is performed cranially up to the carotid bifurcation. The conglomerate can also be seen here to be firmly fused to the external carotid artery. The adventitia is partially resected from the artery in order to separate the conglomerate in sano from the external carotid artery. The specimen can be easily separated on the internal carotid artery. The vagus nerve is also dissected over a long distance. This can also be separated from the lymph node conglomerate with difficulty, but nevertheless in sano. The nerve remains completely intact in its continuity. Same procedure for the hypoglossal nerve. Displacement and re-embedding of the vagus nerve and hypoglossal nerve in the sense of a neurolysis. The course of the accessory nerve must also be dissected sharply from the preparation in part, but its continuity is also preserved. Displacement and, at the end of the operation, re-embedding of the accessory nerve in the sense of a neurolysis. Finally, the entire conglomerate can be removed from the carotid artery and the jugular vein can be traced further upwards. Proximal removal of the internal jugular vein. Stitch around the proximal venous stump. The same is done with the facial vein. Finally, the entire conglomerate can be removed together with the lateral neck preparation. Touch up in the area of the accessorius triangle. Finally, this also results in a neck dissection of levels Ib to V. Here too, separation of the thyroid gland from the laryngeal skeleton. Dissection of the anterior surface of the trachea after cutting through the thyroid isthmus. Opening of the trachea between the 1st and 2nd cartilage clasp and extubation of the patient and insertion of a laryngectomy tube into the distal trachea. Further exposure of the hyoid bone. Finally, opening of the pharynx caudal to the hyoid bone. Successive detachment of the epiglottis and recutting of the epiglottis on the right side over the arytenoid cusps. Partial resection of the pharynx on the left side, where a scarred change is visible in the former tumor area. This entire area is also resected. Finally, the incision is brought together below the arytenoid hump. Further separation of the laryngeal skeleton from the pharynx. The pharynx was first removed from the thyroid cartilage margins. The preparation is then made up to caudal to the cricoid cartilage so that the preparation can be removed in toto. Removal of a marginal sample from the lateral edge of the pharynx on the left side, which is assessed as tumor-free in the frozen section. This shows an R0 resection after all other margins were far away from the tumor. Subtle hemostasis. Closure of the pharynx in three layers. Reconstruction of the infrahyoid musculature, which is also closed before the pharynx. Before closing the pharynx, first perform a paramedian myotomy on the left side. Also insertion of a voice valve prosthesis. This is done retrogradely without any problems. The Provox prosthesis is positioned at a typical location on the upper edge of the tracheostoma to be reconstructed later. Shortening of the medial parts of the sternocleidomastoid muscle at the base of the clavicle. Repeated subtle hemostasis. Insertion of a Redon drain into the neck on both sides. Fold back the apron flap, which is sutured in two layers. Application of a pressure bandage. Intubation of the patient onto a size 10 tracheostomy tube. Final consultation with the anaesthetist. Completion of the procedure without complications. The patient is transferred to the in-house intensive care unit for monitoring. \ No newline at end of file diff --git a/303/InvasionFront_CD3_block5_x5_y1_patient303_0.json b/303/InvasionFront_CD3_block5_x5_y1_patient303_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5097872e480075134568dafffb1c776c5de1ac78 --- /dev/null +++ b/303/InvasionFront_CD3_block5_x5_y1_patient303_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16491.3, + "Centroid Y µm": 2373.7, + "Num Detections": 19511, + "Num Negative": 19184, + "Num Positive": 327, + "Positive %": 1.676, + "Num Positive per mm^2": 127.17 + } +} \ No newline at end of file diff --git a/303/InvasionFront_CD3_block5_x6_y1_patient303_1.json b/303/InvasionFront_CD3_block5_x6_y1_patient303_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a0b49786ca67f886d1580be4e910e1f812ffbd4f --- /dev/null +++ b/303/InvasionFront_CD3_block5_x6_y1_patient303_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 2548.7, + "Num Detections": 19189, + "Num Negative": 18791, + "Num Positive": 398, + "Positive %": 2.074, + "Num Positive per mm^2": 162.89 + } +} \ No newline at end of file diff --git a/303/InvasionFront_CD8_block5_x5_y1_patient303_0.json b/303/InvasionFront_CD8_block5_x5_y1_patient303_0.json new file mode 100644 index 0000000000000000000000000000000000000000..47ddd8d7636ace993c78ffc7fbc3937c0ad39309 --- /dev/null +++ b/303/InvasionFront_CD8_block5_x5_y1_patient303_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 2673.6, + "Num Detections": 20674, + "Num Negative": 20618, + "Num Positive": 56, + "Positive %": 0.2709, + "Num Positive per mm^2": 24.62 + } +} \ No newline at end of file diff --git a/303/InvasionFront_CD8_block5_x6_y1_patient303_1.json b/303/InvasionFront_CD8_block5_x6_y1_patient303_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c820fa69f0de08d46416b274996c3736ae5e957f --- /dev/null +++ b/303/InvasionFront_CD8_block5_x6_y1_patient303_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 2623.6, + "Num Detections": 21960, + "Num Negative": 21776, + "Num Positive": 184, + "Positive %": 0.8379, + "Num Positive per mm^2": 72.9 + } +} \ No newline at end of file diff --git a/303/TumorCenter_CD3_block5_x5_y1_patient303_0.json b/303/TumorCenter_CD3_block5_x5_y1_patient303_0.json new file mode 100644 index 0000000000000000000000000000000000000000..47b2b74e9315927095bd6511063336fe83f50e93 --- /dev/null +++ b/303/TumorCenter_CD3_block5_x5_y1_patient303_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18266.3, + "Centroid Y µm": 2904.0, + "Num Detections": 11054, + "Num Negative": 11021, + "Num Positive": 33, + "Positive %": 0.2985, + "Num Positive per mm^2": 16.89 + } +} \ No newline at end of file diff --git a/303/TumorCenter_CD3_block5_x6_y1_patient303_1.json b/303/TumorCenter_CD3_block5_x6_y1_patient303_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c297c7555bdfa5ea21449f1f66afe01c817ff55e --- /dev/null +++ b/303/TumorCenter_CD3_block5_x6_y1_patient303_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20842.7, + "Centroid Y µm": 3169.6, + "Num Detections": 14479, + "Num Negative": 14275, + "Num Positive": 204, + "Positive %": 1.409, + "Num Positive per mm^2": 87.13 + } +} \ No newline at end of file diff --git a/303/TumorCenter_CD8_block5_x5_y1_patient303_0.json b/303/TumorCenter_CD8_block5_x5_y1_patient303_0.json new file mode 100644 index 0000000000000000000000000000000000000000..837d4a6d4efcf628425fca7717720ebdeda8994e --- /dev/null +++ b/303/TumorCenter_CD8_block5_x5_y1_patient303_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16616.2, + "Centroid Y µm": 2573.6, + "Num Detections": 14171, + "Num Negative": 14160, + "Num Positive": 11, + "Positive %": 0.0776, + "Num Positive per mm^2": 5.585 + } +} \ No newline at end of file diff --git a/303/TumorCenter_CD8_block5_x6_y1_patient303_1.json b/303/TumorCenter_CD8_block5_x6_y1_patient303_1.json new file mode 100644 index 0000000000000000000000000000000000000000..594fc7b1e8d25bf669e8a45f45139d3e0714ff81 --- /dev/null +++ b/303/TumorCenter_CD8_block5_x6_y1_patient303_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19114.9, + "Centroid Y µm": 2623.6, + "Num Detections": 18147, + "Num Negative": 17969, + "Num Positive": 178, + "Positive %": 0.9809, + "Num Positive per mm^2": 73.49 + } +} \ No newline at end of file diff --git a/303/history_text.txt b/303/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/303/icd_codes.txt b/303/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1f185ed365f69875a3640ee9ac0bbcb98e5f463 --- /dev/null +++ b/303/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx Seitenwand[C10.2 R] \ No newline at end of file diff --git a/303/ops_codes.txt b/303/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..50aab725a386bff88a32567776c63a5e6457e383 --- /dev/null +++ b/303/ops_codes.txt @@ -0,0 +1 @@ +Temporäre Tracheotomie[5-311.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Entnahme freier Radialis-Lappen[5-858.23 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 R] Transplantat[5-296.14 ] \ No newline at end of file diff --git a/303/patient_clinical_data.json b/303/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..82de9c5446f2be7759d00a27c5d87e9a7ff2cc52 --- /dev/null +++ b/303/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/303/patient_pathological_data.json b/303/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5a77cab53d84f9c0c4e88daba398dfb7afcf01d7 --- /dev/null +++ b/303/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "303", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Acantholytic", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/303/surgery_description.txt b/303/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e4edc77ca1f21bfa3416fecd07c944affb8fe24a --- /dev/null +++ b/303/surgery_description.txt @@ -0,0 +1 @@ +Resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheotomy, PEG placement diff --git a/303/surgery_report.txt b/303/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..effd78b020d26f15c71df94224a4c0115ebcb362 --- /dev/null +++ b/303/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues, transoral intubation and then sterile washing and draping of the neck area and creation of a tracheotomy by and . Injection of 5 ml Ultracaine with added Suprarenin along the skin incision. Sterile abjoration. Marking of the skin incision. It runs in a line 5 cm long between the cricoid and a point 2 transverse fingers above the jugulum along the median line on the neck. Now sharply cut through the skin, subcutaneous tissue and platysma with the 15 mm scalpel. The anterior jugular vein is exposed and is ligated and cut. Further dissection in depth. The linea alba and the infrahyoid musculature are found. Here dissection after bipolar coagulation. The thyroid gland is now revealed. With the Overholt clamp, the thyroid isthmus is undercut and bipolarly coagulated. A visor tracheotomy is performed between the 3rd and 4th tracheal ring and mucocutaneous anastomosis with Ethibond sutures in the typical manner. Then insertion with the flexible gastroesophagoscope and placement of the PEG through and . Entry with the gastroesophagoscope and air insufflation into the stomach. Once in the stomach, endoscopy of the cardia after inversion of the endoscope. A spontaneous diaphanoscopy can now be seen. A PEG is now placed in loco typico on the anterior wall of the stomach using the suture pull-through method. This was performed without any problems. The patient received Unacid 3 g i.v. perioperatively. Then sterile washing and draping and positioning of the patient and start of inspection of the tumor region by . The tumor extends from the right tonsil to the right palatal arch, passes to the uvula and also extends to the left palatal arch, covering the anterior and posterior palatal arch and the entire soft palate. On the right side, the entire tonsil is tumorously altered and also the pharyngeal side wall up to the vallecula. The base of the tongue is only marginally affected. Now start with transoral tumor resection in the area of the soft palate, the uvula and the soft palate. Then further dissection along the pharyngeal side wall and in the area of the medial parts of the pharynx. Then perform the neck dissection on the right side. To do this, expose the sternocleidomastoid muscle, the submandibular gland, the omohyoid and digastric muscles, the accessorius and hypoglossal nerves and the cervical vascular sheath. Then removal of the metastases and the neck preparation from level II a to V a. Unfortunately, parts of the cervical plexus and the hypoglossal nerve must also be resected here. Then continue the tumor resection from transcervical. To do this, the submandibular gland must be removed and the digastric muscle severed. Then disluxate the tumor and remove the remaining tumor tissue. In the area of the medial pharyngeal border, the tumor resection appears relatively close. A generous resection and a marginal specimen are performed here. Ultimately, all margin samples in the frozen section are R0. Parallel to the tumor resection, the radialis graft is lifted. Due to the resection, the radialis graft is relatively narrow in the caudal section. The pharynx must be gathered here. Carry out the neck dissection on the left side through and .Enter with the 15 mm scalpel and make a skin incision along the anterior border of the sternocleidomastoid muscle from the mastoid to the caudal, in a curved line along the anterior border of the sternocleidomastoid muscle. Sharp transection of the skin, subcutaneous tissue and platysma. The external jugular vein is exposed, ligated and cut. The platysma flap is now dissected using a scalpel. Dissection along the anterior edge of the sternocleidomastoid muscle in depth. The accessorius nerve is now exposed and protected. The accessory nerve is followed in a cranial direction and the posterior belly of the digastric muscle can now be seen. Further medially, the submandibular gland can be seen, which is also easily visualized. The omohyoid muscle is visible caudally. The cervical vascular sheath is visible in the depth below several neck metastases. The internal jugular vein is exposed from caudal to cranial. There is no injury to the structures here. The superior thyroid vein and facial vein are dissected and spared. Medial to the jugular vein, the common carotid artery and the external carotid artery are exposed as well as the vagus nerve and the cervical artery. The neck preparation is now detached in level II b, followed by level II a while sparing the accessorius nerve, and levels III/IV and V are also detached without difficulty. The plexus branches are visualized and specifically spared. No chyle fistula occurs caudally when the neck preparation is removed. The anterior neck preparation is now also exposed and dissected along the facial vein and the superior thyroid vein. Clinically clear evidence of multiple cervical lymph node metastases on the left side. Thus cN2c neck status. The hypoglossal nerve is shown cranially; the nerve is also clearly spared on this side. Elevation of the radial forearm flap on the left by : Palpatory identification of the distal radial artery. Marking of the flap borders (13 x 7 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. The graft is sutured in place by , who also performs the anastomosis in the area of the neck vessels. After removal of the radial artery flap, it is flushed with heparin solution. Insertion of the flap into the defect. It becomes apparent that the defect size slightly exceeds the flap size due to the post-resection. However, the flap can be sutured successively into the defect without tension, sometimes with the sutures in place. Sutures with single button sutures 3-0 Vicryl. The entire defect is successfully covered, except for a small portion in the area of the posterior pharyngeal wall. Here the flap is sutured to the prevertebral fascia. Otherwise, the base of the tongue, pharyngeal side wall and palatal arch area are covered. A gastric tube is inserted to ensure the nasopharyngeal passage. The stalk passed through the right side of the neck is then anastomosed. The superior thyroid artery is selected for the anastomosis. After conditioning, this is sutured to the radial artery or anastomosed with 8-0 Ethilon single-button sutures. After opening the clamps, good arterial flow, good venous return. Subsequent conditioning of the cephalic vein. This is relatively poorly patency distally, but after cutting it back there is good venous return further proximally. The accompanying vein of the radial artery is selected as the 2nd connecting vein, which is, however, very thin. After conditioning the vessels with a 2.5 mm coupler, the cephalic vein is anastomosed with a venous outlet from the middle thyroid vein. Good venous flow after opening the clamps, positive smear phenomenon. The remaining part of the cephalic vein is clipped. The small accompanying vein of the radial vein is anastomosed with another outlet from the thyroid vein using a 1.5 mm coupler after conditioning the vessel ends. Here too, after opening the clamps, good flow, good venous return and positive smear phenomenon. Enoral flap control shows good aspect. Subsequent irrigation of the right side of the neck, hemostasis, layered wound closure and insertion of a total of 2 flaps. Epithelialization of the tracheostoma. This is fixed with stitches. Completion of the procedure without complications. The patient is admitted to the intensive care unit for postoperative monitoring. Flap monitoring for 5 days according to the scheme clinically and via the marked area of the vascular pedicle using vascular Doppler. Continue antibiotics started intraoperatively for a total of 1 week. Feeding via the PEG tube. After approx. 10 days, gruel swallowing and, if necessary, diet build-up. After receiving the final histology, presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/304/InvasionFront_CD3_block6_x5_y8_patient304_0.json b/304/InvasionFront_CD3_block6_x5_y8_patient304_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aeaaacc66f253b16e898272986abc2bbc0f2c8ae --- /dev/null +++ b/304/InvasionFront_CD3_block6_x5_y8_patient304_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16816.1, + "Centroid Y µm": 21188.8, + "Num Detections": 28262, + "Num Negative": 24829, + "Num Positive": 3433, + "Positive %": 12.15, + "Num Positive per mm^2": 1287.3 + } +} \ No newline at end of file diff --git a/304/InvasionFront_CD3_block6_x6_y8_patient304_1.json b/304/InvasionFront_CD3_block6_x6_y8_patient304_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f1b6a5b34330da3b151a49eccc05052f5d318231 --- /dev/null +++ b/304/InvasionFront_CD3_block6_x6_y8_patient304_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19439.7, + "Centroid Y µm": 21313.7, + "Num Detections": 16951, + "Num Negative": 12638, + "Num Positive": 4313, + "Positive %": 25.44, + "Num Positive per mm^2": 2467.8 + } +} \ No newline at end of file diff --git a/304/InvasionFront_CD8_block6_x5_y6_patient304_0.json b/304/InvasionFront_CD8_block6_x5_y6_patient304_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e5835aa2caf69f12871783e53b85361d8010596b --- /dev/null +++ b/304/InvasionFront_CD8_block6_x5_y6_patient304_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17465.8, + "Centroid Y µm": 15441.8, + "Num Detections": 17401, + "Num Negative": 17220, + "Num Positive": 181, + "Positive %": 1.04, + "Num Positive per mm^2": 75.78 + } +} \ No newline at end of file diff --git a/304/InvasionFront_CD8_block6_x6_y6_patient304_1.json b/304/InvasionFront_CD8_block6_x6_y6_patient304_1.json new file mode 100644 index 0000000000000000000000000000000000000000..53eec8d5c39da8dd852538943f867c29163f13dd --- /dev/null +++ b/304/InvasionFront_CD8_block6_x6_y6_patient304_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20114.3, + "Centroid Y µm": 15591.7, + "Num Detections": 16873, + "Num Negative": 16426, + "Num Positive": 447, + "Positive %": 2.649, + "Num Positive per mm^2": 184.57 + } +} \ No newline at end of file diff --git a/304/TumorCenter_CD3_block6_x5_y6_patient304_0.json b/304/TumorCenter_CD3_block6_x5_y6_patient304_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3ba0f27b97d35af5af7c95cbe50be53ecb2853da --- /dev/null +++ b/304/TumorCenter_CD3_block6_x5_y6_patient304_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 15491.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/304/TumorCenter_CD3_block6_x6_y6_patient304_1.json b/304/TumorCenter_CD3_block6_x6_y6_patient304_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4767416f96a76bf9b5f155ed7b232601eded3259 --- /dev/null +++ b/304/TumorCenter_CD3_block6_x6_y6_patient304_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 15192.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/304/TumorCenter_CD8_block6_x5_y6_patient304_0.json b/304/TumorCenter_CD8_block6_x5_y6_patient304_0.json new file mode 100644 index 0000000000000000000000000000000000000000..94b4721369af8dd42ce130541818d238185b6aaf --- /dev/null +++ b/304/TumorCenter_CD8_block6_x5_y6_patient304_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 15666.7, + "Num Detections": 20819, + "Num Negative": 20508, + "Num Positive": 311, + "Positive %": 1.494, + "Num Positive per mm^2": 128.43 + } +} \ No newline at end of file diff --git a/304/TumorCenter_CD8_block6_x6_y6_patient304_1.json b/304/TumorCenter_CD8_block6_x6_y6_patient304_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1b59a3a2786c770346c303e361e9162a97e8d50f --- /dev/null +++ b/304/TumorCenter_CD8_block6_x6_y6_patient304_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 15666.7, + "Num Detections": 18426, + "Num Negative": 17777, + "Num Positive": 649, + "Positive %": 3.522, + "Num Positive per mm^2": 304.98 + } +} \ No newline at end of file diff --git a/304/history_text.txt b/304/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..131b01a79963b1a690cfd80a21d2d4ae0e0521c1 --- /dev/null +++ b/304/history_text.txt @@ -0,0 +1 @@ +Base of tongue carcinoma cT2 cN2a \ No newline at end of file diff --git a/304/icd_codes.txt b/304/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed27a7bcca74b6de644a2fba3c494834b4645476 --- /dev/null +++ b/304/icd_codes.txt @@ -0,0 +1 @@ +Lymphknotenvergrößerung, nicht näher bezeichnet[R59.9 ] \ No newline at end of file diff --git a/304/ops_codes.txt b/304/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..804d77dc4326990db9e5b8b8832bf49d8e16b7c4 --- /dev/null +++ b/304/ops_codes.txt @@ -0,0 +1 @@ +Hemilaryngektomie: Horizontal, supraglottisch mit Zungengrundresektion[5-301.1 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] Tonsillektomie (ohne Adenotomie): Mit Dissektionstechnik[5-281.0 ] Permanente Tracheostomie: Tracheotomie[5-312.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument[1-620.1 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/304/patient_clinical_data.json b/304/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..80fcbb0e004db7092491b8e92fa1ab9d95f5b087 --- /dev/null +++ b/304/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/304/patient_pathological_data.json b/304/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e07a73d500b5e701e58b51a55f2e72df9d68de0a --- /dev/null +++ b/304/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "304", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/304/surgery_description.txt b/304/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b154ccaf902b18bb208fbe8eccf6e4b43da8d1ae --- /dev/null +++ b/304/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Right TE (Total Excision), Bilateral neck dissection, Tracheotomy, PEG placement, Panendoscopy diff --git a/304/surgery_report.txt b/304/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f63d0201069f3860016b0ac6a4e892ad20c741b6 --- /dev/null +++ b/304/surgery_report.txt @@ -0,0 +1 @@ +First, after intubation by the anesthesiology colleagues, entry with the flexible gastroesophagoscope and insertion of a PEG in the usual manner. Then, the Kleinsasser C-tube is inserted and the tumor, which occupies the base of the tongue on the right side, is inspected. The previously described, approx. 1.5 x 1.5 cm exophytic mass can be palpated again. Inspection of the rest of the hypopharynx and larynx, which is unremarkable. Now laser laryngoscope and start with laser excision with 5 watts, generous incisions are made. Monopolar coagulation in between. Removal of the tumor without problems and major bleeding. The tumor is marked on a piece of cardboard. The edges are scored differently as follows. 2 notches correspond to the upper end, 3 notches to the medial end, 4 notches to the lateral end and 1 notch to the lower edge. As the tumor extends to the lower right tonsil pole, a right tonsillectomy is now performed. Insertion of the tonsil plug and dislocation of the tonsil at the upper pole. Mucosal incision close to the uvula and successive dissection of the tonsil from cranial to caudal with the bipolar forceps. Removal with bipolar forceps and insertion of a hydrogen swab. No further bleeding. Now repositioning for neck dissection on both sides, starting on the right. After abjoration, infiltration of 10 ml xylocaine plus adrenaline. Curved skin incision from the tip of the mastoid to just above the jugulum. Locate the omohyoid muscle, then the digastric muscle and finally the accessorius nerve. Expose the accessory nerve and detach the posterior neck preparation from the superior triangle of the accessory nerve. Work out successively from cranial to caudal while protecting the plexus branches. At the lower third, a large metastasis is encountered, which rests on the jugular vein and extends anteriorly. Now turn towards the metastasis and successive sharp dissection of the metastasis from the vessel. However, this is not clinically infiltrated, so the jugular vein is removed. After removal of the large metastasis and protection of the surrounding structures, further removal of the posterior neck preparation while protecting the plexus branches. Hemostasis with the bipolar forceps. Now complete the neck dissection in the sense of the anterior neck region II, III and IV. Dissection of the submandibular gland, taking its capsule with it. Now expose the hypoglossal nerve. The vagus nerve and the common carotid artery could be visualized during the preparation without any problems. As the laser resection was performed far laterally and the fatty tissue is already visible, the superior thyroid artery and lingual artery are now selectively ligated to prevent bleeding. Locate the two vessels after identifying the common carotid artery and identifying the external and internal carotid arteries. Now ligature both vessels. This was successful without any problems. Then flush with hydrogen and Ringer. Now turn to the left side. After a curved skin incision, also from the tip of the matoid to just above the jugulum, expose the anterior edge of the sternocleidomastoid muscle, the omohyoid muscle and the digastric muscle. Now dissect the digastric muscle in the direction of the submandibular capsule and remove it. Locate the accessor nerve and expose it. Now work out the posterior neck preparation from cranial to caudal starting at the upper accessorius triangle. The plexus branches can also be spared. Also clearly enlarged lymph nodes despite the sonographic cN2a status. Removal of all lymph nodes. Removal of a lymph vessel caudally ................. Now freeing of the internal jugular vein. Complete the anterior neck preparation and expose the hypoglossal nerve. After removal of the neck preparation, hemostasis with the bipolar, hydrogen irrigation and ring irrigation. Now insertion of 2 Redon drains on both sides and two-layer wound closure. Finally, perform the tracheostomy. First inject 4 ml xylocaine and adrenaline 2 cm above the jugulum. Modified Kocher collar incision and transection of the subcutis. A large prethyroid vein is ligated. Then dissect the trachea and expose the thyroid isthmus, which is massively enlarged. Undermining of the thyroid gland and removal of the isthmus by means of two re-punctures. Entry into the trachea between the 2nd and 3rd tracheal clasp. Creation of a modified Björ flap. Suturing or epithelization of the tracheostoma and insertion of an 8-gauge cannula. Finally, re-inspection of the base of the tongue and the tonsillar larynx, followed by discrete monopolar coagulation. The patient is transferred to the intensive care unit for monitoring. \ No newline at end of file diff --git a/305/InvasionFront_CD3_block22_x5_y8_patient305_0.json b/305/InvasionFront_CD3_block22_x5_y8_patient305_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9ee8ef3183982cb36951282c4209714baaef826f --- /dev/null +++ b/305/InvasionFront_CD3_block22_x5_y8_patient305_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 31808.2, + "Num Detections": 19998, + "Num Negative": 19061, + "Num Positive": 937, + "Positive %": 4.685, + "Num Positive per mm^2": 407.42 + } +} \ No newline at end of file diff --git a/305/InvasionFront_CD3_block22_x6_y8_patient305_1.json b/305/InvasionFront_CD3_block22_x6_y8_patient305_1.json new file mode 100644 index 0000000000000000000000000000000000000000..233e6b0b58e3d542ca82111388ca270bc5d9ce4e --- /dev/null +++ b/305/InvasionFront_CD3_block22_x6_y8_patient305_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19639.6, + "Centroid Y µm": 31683.2, + "Num Detections": 17335, + "Num Negative": 16853, + "Num Positive": 482, + "Positive %": 2.781, + "Num Positive per mm^2": 250.3 + } +} \ No newline at end of file diff --git a/305/InvasionFront_CD8_block22_x5_y8_patient305_0.json b/305/InvasionFront_CD8_block22_x5_y8_patient305_0.json new file mode 100644 index 0000000000000000000000000000000000000000..449592ee8898e27b98be0a2140d5694912ae3169 --- /dev/null +++ b/305/InvasionFront_CD8_block22_x5_y8_patient305_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19483.6, + "Centroid Y µm": 19937.8, + "Num Detections": 18530, + "Num Negative": 18188, + "Num Positive": 342, + "Positive %": 1.846, + "Num Positive per mm^2": 158.09 + } +} \ No newline at end of file diff --git a/305/InvasionFront_CD8_block22_x6_y8_patient305_1.json b/305/InvasionFront_CD8_block22_x6_y8_patient305_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5c1d253d175b93c628dfb9caf6143d39446ba4b5 --- /dev/null +++ b/305/InvasionFront_CD8_block22_x6_y8_patient305_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 22017.6, + "Centroid Y µm": 19682.8, + "Num Detections": 15770, + "Num Negative": 15521, + "Num Positive": 249, + "Positive %": 1.579, + "Num Positive per mm^2": 139.27 + } +} \ No newline at end of file diff --git a/305/TumorCenter_CD3_block22_x5_y8_patient305_0.json b/305/TumorCenter_CD3_block22_x5_y8_patient305_0.json new file mode 100644 index 0000000000000000000000000000000000000000..07bed103438ebd0f525196d109e6f98dcf16ee77 --- /dev/null +++ b/305/TumorCenter_CD3_block22_x5_y8_patient305_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 20539.1, + "Num Detections": 15613, + "Num Negative": 15347, + "Num Positive": 266, + "Positive %": 1.704, + "Num Positive per mm^2": 152.02 + } +} \ No newline at end of file diff --git a/305/TumorCenter_CD3_block22_x6_y8_patient305_1.json b/305/TumorCenter_CD3_block22_x6_y8_patient305_1.json new file mode 100644 index 0000000000000000000000000000000000000000..df237fbd20a754c5ca47a8ddb700869a8eb7ac08 --- /dev/null +++ b/305/TumorCenter_CD3_block22_x6_y8_patient305_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 20539.1, + "Num Detections": 19503, + "Num Negative": 19249, + "Num Positive": 254, + "Positive %": 1.302, + "Num Positive per mm^2": 116.5 + } +} \ No newline at end of file diff --git a/305/TumorCenter_CD8_block22_x5_y8_patient305_0.json b/305/TumorCenter_CD8_block22_x5_y8_patient305_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1bdfec111f7b0daf3db7a714c94926301048d338 --- /dev/null +++ b/305/TumorCenter_CD8_block22_x5_y8_patient305_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 29984.1, + "Num Detections": 19068, + "Num Negative": 18892, + "Num Positive": 176, + "Positive %": 0.923, + "Num Positive per mm^2": 79.4 + } +} \ No newline at end of file diff --git a/305/TumorCenter_CD8_block22_x6_y8_patient305_1.json b/305/TumorCenter_CD8_block22_x6_y8_patient305_1.json new file mode 100644 index 0000000000000000000000000000000000000000..769af80c319cf918909345206cb646f3f4c6cf02 --- /dev/null +++ b/305/TumorCenter_CD8_block22_x6_y8_patient305_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21263.7, + "Centroid Y µm": 30059.1, + "Num Detections": 20732, + "Num Negative": 20530, + "Num Positive": 202, + "Positive %": 0.9743, + "Num Positive per mm^2": 92.83 + } +} \ No newline at end of file diff --git a/305/history_text.txt b/305/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/305/icd_codes.txt b/305/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..63452881019372b3fd4790a329ae2bac3eacc7c8 --- /dev/null +++ b/305/icd_codes.txt @@ -0,0 +1 @@ +Larynxkarzinom[C32.9 ] \ No newline at end of file diff --git a/305/ops_codes.txt b/305/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ffede5a050981d1c5178ef07abb317a1180713f --- /dev/null +++ b/305/ops_codes.txt @@ -0,0 +1 @@ +Sonstige einfache Laryngektomie[5-303.0x ] Permanente Tracheostomaanlage[5-312.0 ] Einlegen Wechsel und Entfernung Sprechkanüle[8-149.x B] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 2 Regionen[5-403.01 B] Ösophagomyotomie pharyngozervikal sonstige[5-420.1x ] \ No newline at end of file diff --git a/305/patient_clinical_data.json b/305/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..35812d16e5d7ff2ee402566cc814678bb30e8ab9 --- /dev/null +++ b/305/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 47, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 8, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/305/patient_pathological_data.json b/305/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5197f752bde9e7b4bbd7769672f1cb71ad72301a --- /dev/null +++ b/305/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "305", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 8, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/305/surgery_description.txt b/305/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b0b7a149d7a04f0966bf049f5277fdd7cf6a1fb7 --- /dev/null +++ b/305/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, Tracheotomy diff --git a/305/surgery_report.txt b/305/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cbabad47a3114ba6e952a7e02c28c15feaedacdc --- /dev/null +++ b/305/surgery_report.txt @@ -0,0 +1 @@ +Initially started by . Patient identification, consultation with anesthesia colleagues. Carrying out the team time-out. Induction of anesthesia and intubation by anesthesia colleagues. Tracheobronchoscopy is not possible here if intubation conditions are difficult. Now intubation with the small bore tube. No suspicious mass in the oral cavity, oropharynx, base of tongue, vallecula, epiglottis, aryepiglottic f......s and postcricoid area. The mass/tumor grows from the pocket fold on the left, completely infiltrating the vocal fold and extending over the anterior commissure to the vocal fold on the right, growing circularly on the left and extending 2 cm to the subglottic area. Skin disinfection of the surgical area. Infiltration anesthesia in the area of the apron flap. Repeated skin disinfection of the surgical area and sterile draping of the surgical area. Now mark the landmarks, jugulum, mastoid, chin, sternocleidomastoid anterior border, jaw angle and mandibular branch on both sides and mark the apron flap up to approximately 2 to 3 cm cranial to the jugulum. Make the skin incision using an electric needle through . Subsequently, further preparation of the neck dissection by . First cut through the platysma and develop the apron flap subplatysmal to cranial. This is fixed with holding sutures. Then expose the anterior margin of the sternocleidomastoid and dissect along it. Exposure of the omohyoid and exposure of the right mandibular salivary gland. Exposure of the digaster venter muscle anteriorly and posteriorly. Visualization of the auricularis magnus. Exposure of the accessorius nerve and protection of the same. Demonstration of findings to . He recommends dissecting only level II from the jugular vein medially and an identical procedure on the opposite side. This is carried out. Exposure of the hypoglossal nerve, the jugular vein and the facial vein. All structures are spared. An enlarged lymph node is located in the jugulofacial angle, which does not appear to be primarily suspicious. This neck specimen is sent for final histology. Now identical procedure on the opposite side. The external jugular vein is exposed and spared. The anterior border of the sternocleidomastoid, the omohyoid and the posterior and anterior digaster venter muscles and the mandibular salivary gland as well as the hypoglossus and the accessorius are also exposed and spared. The neck preparation is also dissected medially from the jugular vein and cranially from the bifurcation to the medial side. A lymph node is also enlarged here, but not suspicious. The facial vein and internal jugular vein are also exposed and spared here. Now expose the omohyoid muscle and skeletonize it. The tumor is now resected: the hyoid bone is exposed and the infrahyoid muscles are dissected on both sides, detached from the larynx and folded laterally and caudally. Detachment of the supraglottic soft tissues up to the pharyngeal wall. The soft tissues go with the larynx to the specimen. Expose the thyroid isthmus and cut it. Dissect the thyroid gland together with the overlying infrahyoid musculature caudolaterally from the laryngeal skeleton. This is done in the same way on both sides. Individual branches of the superior thyroid artery are supplied or ligated bipolarly, the artery remains intact on both sides. Exposure of the trachea on the upper 4 to 5 cm. The trachea is now opened in the 2nd/3rd intercartilaginous space with epithelialization of the caudal part. No tumor here. Then expose the cornu superius on both sides and detach the pharyngeal muscles or the constrictor pharyngis on both sides. Push off the piriform sinus on both sides. Subsequent entry into the pharyngeal space at the level of the epiglottis. Exposure of the tumor. Successive development of the larynx. Detachment below the postcricoid region from the esophageal tube. Subsequent separation of the larynx from the trachea, which remains slightly elongated dorsally towards the cranium. Larynx is suture-marked for frozen section. In the frozen section, the tumor is relatively close dorsally in the area of the cricoid cartilage, no tumor infestation in the area of the trachea, here the clearly subglottically growing carcinoma is tumor-free or removed in healthy tissue. Resection of soft tissue on the esophageal tube from paramedian right to left is now performed again. A portion of the caudal hypopharynx in the area of the postcricoid mucosa is also removed again. Both specimens are sent for frozen section. No more tumor infiltrates here, so the tumor is finally removed from the healthy tissue. The myotomy is now performed in the typical manner on the left. Significantly improved by passage of the finger. Muscle bundles are cut through to the mucosa. Subsequent insertion of an 8 mm Provox prosthesis in the typical manner without problems. Good fit. Then 1st inverting suture with 4.0 Vicryl single button sutures inverting. A 2nd inverting suture of the musculature is performed over the 1st suture, also in single button sutures with Vicryl 3.0. Then a 3rd suture with adaptation of the constrictor pharyngis musculature, suprahyoidal constrictor pharyngis muscle is also adapted to the supraglottic musculature. The thyroid gland is adapted caudally over the suture area. Subsequent careful irrigation and hemostasis of the entire area. Wound closure in layers without insertion of a Redon drain in each side of the neck and epithelialization of the tracheostoma. Finally, insertion of a 10 mm tracheostomy tube. The procedure was completed without complications. Overall cT3 to 4 transglottic carcinoma on the left side, no clear clinical lymph node involvement observed. Further procedure after receipt of the final histology. Presentation at the interdisciplinary tumor conference. Postoperatively, the patient is ventilated and admitted to the intensive care unit. Nutrition here via the inserted gastric tube for 10 days, then gruel swallowing and, if necessary, diet build-up. Please continue antibiotics, which were started intraoperatively with Unacid, for 1 week. \ No newline at end of file diff --git a/306/InvasionFront_CD3_block8_x5_y12_patient306_0.json b/306/InvasionFront_CD3_block8_x5_y12_patient306_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1da13f31c8b83ecb994908fdb367ac1b7757a872 --- /dev/null +++ b/306/InvasionFront_CD3_block8_x5_y12_patient306_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 40253.7, + "Num Detections": 20296, + "Num Negative": 19998, + "Num Positive": 298, + "Positive %": 1.468, + "Num Positive per mm^2": 118.7 + } +} \ No newline at end of file diff --git a/306/InvasionFront_CD3_block8_x6_y12_patient306_1.json b/306/InvasionFront_CD3_block8_x6_y12_patient306_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e07296b3ad71e82a90b92a00a36115ad4ec45da7 --- /dev/null +++ b/306/InvasionFront_CD3_block8_x6_y12_patient306_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19139.9, + "Centroid Y µm": 40353.6, + "Num Detections": 15093, + "Num Negative": 14651, + "Num Positive": 442, + "Positive %": 2.929, + "Num Positive per mm^2": 212.58 + } +} \ No newline at end of file diff --git a/306/InvasionFront_CD8_block8_x5_y12_patient306_0.json b/306/InvasionFront_CD8_block8_x5_y12_patient306_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6bc7565a6d4135af1ddcfa69bda01d0a320dc3be --- /dev/null +++ b/306/InvasionFront_CD8_block8_x5_y12_patient306_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15716.7, + "Centroid Y µm": 30933.6, + "Num Detections": 21715, + "Num Negative": 21281, + "Num Positive": 434, + "Positive %": 1.999, + "Num Positive per mm^2": 175.69 + } +} \ No newline at end of file diff --git a/306/InvasionFront_CD8_block8_x6_y12_patient306_1.json b/306/InvasionFront_CD8_block8_x6_y12_patient306_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ed1658413944a2eddd1e3fb8ecb9c5d790ca036d --- /dev/null +++ b/306/InvasionFront_CD8_block8_x6_y12_patient306_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18090.4, + "Centroid Y µm": 31133.5, + "Num Detections": 18279, + "Num Negative": 17885, + "Num Positive": 394, + "Positive %": 2.155, + "Num Positive per mm^2": 188.8 + } +} \ No newline at end of file diff --git a/306/TumorCenter_CD3_block8_x5_y12_patient306_0.json b/306/TumorCenter_CD3_block8_x5_y12_patient306_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0ddb519c580787bdfcd4781a7fc12538ae210384 --- /dev/null +++ b/306/TumorCenter_CD3_block8_x5_y12_patient306_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 30983.6, + "Num Detections": 18624, + "Num Negative": 17450, + "Num Positive": 1174, + "Positive %": 6.304, + "Num Positive per mm^2": 523.74 + } +} \ No newline at end of file diff --git a/306/TumorCenter_CD3_block8_x6_y12_patient306_1.json b/306/TumorCenter_CD3_block8_x6_y12_patient306_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7c146b323c1a9aaf6a9a30b1a6f4d65352910118 --- /dev/null +++ b/306/TumorCenter_CD3_block8_x6_y12_patient306_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21313.7, + "Centroid Y µm": 30583.8, + "Num Detections": 13478, + "Num Negative": 12603, + "Num Positive": 875, + "Positive %": 6.492, + "Num Positive per mm^2": 467.66 + } +} \ No newline at end of file diff --git a/306/TumorCenter_CD8_block8_x5_y12_patient306_0.json b/306/TumorCenter_CD8_block8_x5_y12_patient306_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6dc52e68470cf912ee7424a3309ebb3f19cad78f --- /dev/null +++ b/306/TumorCenter_CD8_block8_x5_y12_patient306_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17590.7, + "Centroid Y µm": 30009.1, + "Num Detections": 23324, + "Num Negative": 23042, + "Num Positive": 282, + "Positive %": 1.209, + "Num Positive per mm^2": 125.1 + } +} \ No newline at end of file diff --git a/306/TumorCenter_CD8_block8_x6_y12_patient306_1.json b/306/TumorCenter_CD8_block8_x6_y12_patient306_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f67a98b7030e26a2c15a34383b078ba2986d46e2 --- /dev/null +++ b/306/TumorCenter_CD8_block8_x6_y12_patient306_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20114.3, + "Centroid Y µm": 29784.2, + "Num Detections": 23158, + "Num Negative": 23022, + "Num Positive": 136, + "Positive %": 0.5873, + "Num Positive per mm^2": 60.6 + } +} \ No newline at end of file diff --git a/306/history_text.txt b/306/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce659a2bbad8497c26d4e8ea68b21389d8781875 --- /dev/null +++ b/306/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the tonsil lobe, oropharyngeal side wall and base of tongue. At least one lymph node metastasis on the right in the imaging. Continuous growth cannot be ruled out. Therefore, the above-mentioned surgery is indicated. \ No newline at end of file diff --git a/306/icd_codes.txt b/306/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/306/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/306/ops_codes.txt b/306/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ae71ca1b8b91e79a5d5b4a723d5c4818b18eb50d --- /dev/null +++ b/306/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.14 ] Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Rekonstruktion mit gestieltem Fernlappen[5-295.05 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 B] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] \ No newline at end of file diff --git a/306/patient_clinical_data.json b/306/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..941b9ee26c09b5b24bc3bfd19afaa82061dd7225 --- /dev/null +++ b/306/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 7, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/306/patient_pathological_data.json b/306/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..83cc12fb86c329a3649613bd5bd5a98ad79e5b45 --- /dev/null +++ b/306/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "306", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 22.0 +} \ No newline at end of file diff --git a/306/surgery_description.txt b/306/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ddfe61d0f6a132391a58fe8c7a7bdcd652aff7ce --- /dev/null +++ b/306/surgery_description.txt @@ -0,0 +1 @@ +Pharyngeal partial resection, Neck dissection, Free flap (Radial), PEG placement diff --git a/306/surgery_report.txt b/306/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..49f77bbf93e8d9f8d37c170edb28d962284d166d --- /dev/null +++ b/306/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesiologist. First pharyngoscopy and laryngoscopy: The exophytic tumor is seen, which begins at the right tonsillar lobe and extends down the glossotonsillar groove into the base of the tongue. Palpatorily just reaching the middle of the tongue base. Caudal to the entrance to the hypopharynx. Thus confirming the indication for surgery. Dictation : First neck dissection of the left side. Curved skin incision along the anterior edge of the sternocleidomastoid. Dissection through the subcutaneous tissue and platysma. Exposure of the anterior edge of the sternocleidomastoid muscle, the omohyoid muscle, the posterior digastric venter muscle and also the accessorius nerve. Displacement, neurolysis and re-embedding of the accessorius nerve. Subsequent dissection of the internal jugular vein from caudal to cranial. Isolation of the cervical vascular sheath laterally and formation of the lateral neck preparation from cranial to caudal while sparing the accessory nerve and the plexus branches. Turn to the medial neck preparation. Dissection of the submandibular gland, the facial vein, the hypoglossal nerve and protection of the latter. Displacement, neurolysis and re-embedding of the hypoglossal nerve. Subsequent resection of the medial neck preparation while sparing the structures mentioned. At the end of the operation, placement of a Redon drain and two-layer wound closure using subcutaneous and skin sutures. Pressure bandage. Neck dissection of the right side. Level II shows clearly enlarged lymph node metastases. Otherwise identical procedure. Dissection along the anterior edge of the sternocleidomastoid. Identification of the omohyoid muscle, the posterior digastric venter muscle and the accessorius nerve and dissection of the internal jugular vein from caudal to cranial. Displacement, neurolysis and re-embedding of the accessorius nerve. The metastases can also be removed from the vessel. Subsequent formation of the lateral neck preparation while sparing the accessorius nerve and the plexus branches. Exposure, displacement, neurolysis and re-embedding of the hypoglossal nerve. Then resection of the medial neck preparation while sparing the hypoglossal nerve and the facial vein. Creation of a Redon drainage, two-layer wound closure. Pressure dressing. Transition to tracheotomy: X-shaped skin incision. Dissection through the subcutaneous tissue and platysma. Spreading of the pretracheal muscles. Identification of the cricoid cartilage. The thyroid isthmus is revealed very far caudally and is only bipolized. Then open the trachea between the 2nd and 3rd tracheal ring. Formation of a Björk flap and epithelialization of the flap using six tracheostomy sutures. PEG placement: Flexible esophagogastroscopy. After positive diaphanoscopy, placement of the PEG tube in the typical manner using the thread pull-through method. Dictation : Subsequent combined transoral transcervical tumor resection: First dissection of the pharyngeal wall and dissection of all vessels from the outside. Cut around the tumor from the inside transorally as far as possible. This can be done cranially and along the lower jaw. Controlled dissection from the inside to the outside. Inclusion of the entire pharyngeal wall. Extraction of the tumor into the soft tissues of the neck. Further resection with a safety margin of at least 1.5 cm on all sides. The tonsil lobe, pharyngeal side wall, glossotonsillar groove and base of the tongue up to half as well as parts of the vallecula and the pharyngeal wall up to the hypopharyngeal entrance were removed. As part of the resection, the submandibular gland was also resected as well as parts of the external tongue musculature with parts of the hyoid bone. The tumor is thread-marked after resection. Marginal samples are taken from the hypopharynx and from the area of the pharyngeal wall extending to the uvula, from the base of the tongue, from the body of the tongue and a marginal sample from the alveolar ridge, which extends to the base of the tongue via the glossotonsillar groove. No evidence of carcinoma in any of the marginal samples. No high-grade dysplasia. Therefore R0 situation. After measuring the defect in its three-dimensional dimensions, removal of the radial lobe on the left forearm: Flap length maximum 10 cm, width maximum 7 cm. Flap shape is adjusted to the defect towards the floor of the mouth and base of the tongue. First cut ulnarly and lift subfascially. The ulnar artery is carefully spared. The incision is then extended into the antecubital fossa. First expose the superficial venous system and dissect it. Then expose the pedicle under the brachioradialis. Then incision of the flap from radial and subfascial elevation. The antebrachial cutaneous nerve is carefully spared. Caudal clamping of the radial artery. Saturation always at 100%. After approx. 15 minutes without a drop in saturation, the radial artery is removed. This is stitched and ligated with 4.0 Ethilon single button sutures. This is done both proximally and distally. Lift the flap subfascially with the pedicle and superficial venous system successively up to the antecubital fossa. Outgoing vessels are either ligated, bipolar coagulated or treated with a clip. Exposure in the antecubital fossa, connection between superficial and deep venous system. Exposure of the radial artery. The interosseous artery is first clamped off and can be supplied with clips and cut after a constant saturation of 100%. No confluence of the radial artery can be shown. Two outlets from the area of the cephalic vein can be visualized, which can be considered as connecting vessels. The flap is then removed. The veins are ligated. The artery is treated with 6.0 Vascufil stitches. Careful hemostasis is then performed. Removal of an appropriately sized piece of full-thickness skin from the groin area. After skin mobilization, the skin is closed in several layers with the insertion of a Redon drain. The full-thickness skin is inserted into the forearm defect after appropriate thinning. Fixation using 4.0 Ehtilon sutures. Skin closure up to the crook of the elbow in layers. Application of a hydrogel/Mepilex dressing. Application of Wölkchen compresses on top. Wrapping in absorbent cotton. Application or adjustment of a Kramer splint and wrapping of the arm in a functional position using an elastic bandage on the Kramer splint. Saturation always at 100%. Positioning of the arm. Insertion and suturing of the flap into the pharyngeal defect: passing the stem through to the soft tissues of the neck. Successive suturing of the flap into the defect using 3.0 Vicryl single button sutures according to the three-dimensional arrangement without tension. Suturing is performed partly transorally, partly transcervically and partly with the sutures in place. Complete tension-free closure. Subsequent conditioning of the flap vessels and conditioning of the connecting vessels. The lingual artery is selected. It is conditioned and anastomosed to the radial artery using 8.0 Ethilon single-button sutures. After opening the clamp, good arterial flow, good venous return. Subsequent conditioning of the larger vein from the area of the cephalic vein. Conditioning of the facial vein. Selection of a 3.5 mm coupler. Anastomosis of the veins without difficulty using a coupler. Good venous return after opening the clamps. Positive smear phenomenon. The other outlet on the cephalic vein is clipped. Careful hemostasis in the entire neck area. Irrigation. Wound closure in layers with insertion of a Redon drain in both sides of the neck. The inserted 8 mm tracheostomy tube is fixed with a suture. The site intended for Doppler control is marked with suture. Final transoral check shows well perfused flap. The procedure is completed without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue the antibiotic treatment with Unacid started intraoperatively for at least 2-3 days postoperatively. Feeding via the PEG tube for at least 10 days, then gruel and, if necessary, diet build-up. Continue intraoperative heparin therapy using a 500 I.U. per hour perfusor for at least 5 days postoperatively. Flap control transorally or by means of Doppler according to scheme. 30 body elevation. Total cT3 cN2b oropharyngeal carcinoma on the right. Presentation of the patient at the interdisciplinary tumor conference to determine the adjuvant therapy according to the final histology. Final consultation with the anesthesia department. \ No newline at end of file diff --git a/307/InvasionFront_CD3_block17_x5_y8_patient307_0.json b/307/InvasionFront_CD3_block17_x5_y8_patient307_0.json new file mode 100644 index 0000000000000000000000000000000000000000..35fa828e498593df4c13b2bd4573daa737016d89 --- /dev/null +++ b/307/InvasionFront_CD3_block17_x5_y8_patient307_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 25436.5, + "Num Detections": 18470, + "Num Negative": 17578, + "Num Positive": 892, + "Positive %": 4.829, + "Num Positive per mm^2": 430.95 + } +} \ No newline at end of file diff --git a/307/InvasionFront_CD3_block17_x6_y8_patient307_1.json b/307/InvasionFront_CD3_block17_x6_y8_patient307_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ec8da91ce9ff1d72f8ee37d39cb67be9b531ce30 --- /dev/null +++ b/307/InvasionFront_CD3_block17_x6_y8_patient307_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 25536.5, + "Num Detections": 18756, + "Num Negative": 17686, + "Num Positive": 1070, + "Positive %": 5.705, + "Num Positive per mm^2": 504.5 + } +} \ No newline at end of file diff --git a/307/InvasionFront_CD8_block17_x5_y8_patient307_0.json b/307/InvasionFront_CD8_block17_x5_y8_patient307_0.json new file mode 100644 index 0000000000000000000000000000000000000000..898bb304eecbc0046d3cef255d45f18e9a264c69 --- /dev/null +++ b/307/InvasionFront_CD8_block17_x5_y8_patient307_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 20339.2, + "Num Detections": 18368, + "Num Negative": 17780, + "Num Positive": 588, + "Positive %": 3.201, + "Num Positive per mm^2": 278.59 + } +} \ No newline at end of file diff --git a/307/InvasionFront_CD8_block17_x6_y8_patient307_1.json b/307/InvasionFront_CD8_block17_x6_y8_patient307_1.json new file mode 100644 index 0000000000000000000000000000000000000000..928796de2aa040b5dcc500ef3602edd37d71ca69 --- /dev/null +++ b/307/InvasionFront_CD8_block17_x6_y8_patient307_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 20414.2, + "Num Detections": 18804, + "Num Negative": 18011, + "Num Positive": 793, + "Positive %": 4.217, + "Num Positive per mm^2": 361.87 + } +} \ No newline at end of file diff --git a/307/TumorCenter_CD3_block17_x5_y8_patient307_0.json b/307/TumorCenter_CD3_block17_x5_y8_patient307_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1cbebb9ee4f6f7303d95a0b378c983ce8578fb5c --- /dev/null +++ b/307/TumorCenter_CD3_block17_x5_y8_patient307_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15841.6, + "Centroid Y µm": 20039.4, + "Num Detections": 13635, + "Num Negative": 12614, + "Num Positive": 1021, + "Positive %": 7.488, + "Num Positive per mm^2": 606.55 + } +} \ No newline at end of file diff --git a/307/TumorCenter_CD3_block17_x6_y8_patient307_1.json b/307/TumorCenter_CD3_block17_x6_y8_patient307_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f3460a3db60ed1d954e7cdaaf459bcae475f723 --- /dev/null +++ b/307/TumorCenter_CD3_block17_x6_y8_patient307_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 20064.4, + "Num Detections": 12334, + "Num Negative": 10859, + "Num Positive": 1475, + "Positive %": 11.96, + "Num Positive per mm^2": 897.79 + } +} \ No newline at end of file diff --git a/307/TumorCenter_CD8_block17_x5_y8_patient307_0.json b/307/TumorCenter_CD8_block17_x5_y8_patient307_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b281aa5e696d9eaaa9cd4d5a228cf543c6d59726 --- /dev/null +++ b/307/TumorCenter_CD8_block17_x5_y8_patient307_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 33682.2, + "Num Detections": 20672, + "Num Negative": 19609, + "Num Positive": 1063, + "Positive %": 5.142, + "Num Positive per mm^2": 485.31 + } +} \ No newline at end of file diff --git a/307/TumorCenter_CD8_block17_x6_y8_patient307_1.json b/307/TumorCenter_CD8_block17_x6_y8_patient307_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b5ca2eca7962d1f208339550865828215506bfe4 --- /dev/null +++ b/307/TumorCenter_CD8_block17_x6_y8_patient307_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21413.7, + "Centroid Y µm": 33632.2, + "Num Detections": 18657, + "Num Negative": 17741, + "Num Positive": 916, + "Positive %": 4.91, + "Num Positive per mm^2": 415.47 + } +} \ No newline at end of file diff --git a/307/history_text.txt b/307/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..256ec2ab9b9548923098cfaff01fa1bae64f813a --- /dev/null +++ b/307/history_text.txt @@ -0,0 +1 @@ +The patient has an externally histologically confirmed squamous cell carcinoma of the right edge of the tongue. Therefore indication for the above-mentioned operation. \ No newline at end of file diff --git a/307/icd_codes.txt b/307/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb81590de3ce161665750de0e1ae957661869a41 --- /dev/null +++ b/307/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] Zungenrandkarzinom[C02.1 ] \ No newline at end of file diff --git a/307/ops_codes.txt b/307/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8682916acd0cefec665431fa3467b5f711b0db01 --- /dev/null +++ b/307/ops_codes.txt @@ -0,0 +1 @@ +Biopsie an anderen Strukturen des Mundes und der Mundhöhle durch Inzision: Sonstige[1-545.x ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/307/patient_clinical_data.json b/307/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..13e0a836c689e8e56bc7045e2b1e76beacc86a97 --- /dev/null +++ b/307/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/307/patient_pathological_data.json b/307/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a13369a302ca4e809432fad35136fe6b6d42ffe8 --- /dev/null +++ b/307/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "307", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/307/surgery_description.txt b/307/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ab6802cce3ba6d869b2571e7fced1445d1df0d69 --- /dev/null +++ b/307/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy, Panendoscopy diff --git a/307/surgery_report.txt b/307/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..05a7c911d7a6c514b317ce1e78548ed792c08c02 --- /dev/null +++ b/307/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, the surgeon first performs a tracheoscopy using the 0 degree scope. Tracheoscopy is only possible up to approx. 1 cm subglottically. Here, the mucosal conditions are unremarkable with no evidence of stenosis. Subsequent nasal intubation by the anesthesia colleagues. Start of flexible esophagogastroscopy. Careful screening with the flexible endoscope through the oesophagus into the stomach. Chronic inflammatory mucosa on all sides of the stomach in the form of gastritis with no evidence of exophytic masses. Retraction of the flexible gastroscope and detailed inspection of the esophagus. Mucosal conditions unremarkable on all sides. Position the patient and first inspect the oral cavity. This reveals a carcinoma of the edge of the tongue on the right side, which occupies approximately the anterior third of the tongue and extends just to the midline, appearing coarse on palpation, with no abnormalities on palpation of the floor of the mouth and the base of the tongue. Entry with the type C small bore tube and inspection of the oropharynx and hypopharynx. Epiglottis, vallecula and base of tongue free on both sides, the piriform sinus can also be freely unfolded on both sides, the arytenoid region and postcricoid as well as the esophageal entrance are also free. Endolaryngeal protrusion is extremely difficult even with the type D small bore tube. The anterior commissure cannot be seen, otherwise inconspicuous mucosal conditions and smooth vocal folds without exophytic masses. Subsequent transition to excision biopsy of the right edge of the tongue. Insertion of an oral retractor and looping of the tongue with a Vicryl suture. Marking of the resection margins using monopolar coagulation and palpation. Subsequent excision of the tongue tumor after bipolar coagulation with scissors. Ligation of a small vein in the area of the floor of the mouth and suture marking of the removed tongue resectate. A resectate is obtained in the area of the posterior floor of the mouth. The samples taken are sent for final histology. Finally, careful hemostasis using bipolar coagulation. Relaxation of the oral retractor and recheck. The operation is completed without complications or bleeding. \ No newline at end of file diff --git a/308/InvasionFront_CD3_block17_x3_y4_patient308_0.json b/308/InvasionFront_CD3_block17_x3_y4_patient308_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a9e001031542f91b879724f16b17d1d2b8b6365d --- /dev/null +++ b/308/InvasionFront_CD3_block17_x3_y4_patient308_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 15067.0, + "Num Detections": 21095, + "Num Negative": 19045, + "Num Positive": 2050, + "Positive %": 9.718, + "Num Positive per mm^2": 810.27 + } +} \ No newline at end of file diff --git a/308/InvasionFront_CD3_block17_x4_y4_patient308_1.json b/308/InvasionFront_CD3_block17_x4_y4_patient308_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ee4cafa5a0437cc108843769b2ec598061132817 --- /dev/null +++ b/308/InvasionFront_CD3_block17_x4_y4_patient308_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 15167.0, + "Num Detections": 21816, + "Num Negative": 20410, + "Num Positive": 1406, + "Positive %": 6.445, + "Num Positive per mm^2": 519.35 + } +} \ No newline at end of file diff --git a/308/InvasionFront_CD8_block17_x3_y4_patient308_0.json b/308/InvasionFront_CD8_block17_x3_y4_patient308_0.json new file mode 100644 index 0000000000000000000000000000000000000000..86aafa94e4a71584a06ab5fa3b145186dd71f992 --- /dev/null +++ b/308/InvasionFront_CD8_block17_x3_y4_patient308_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 10294.5, + "Num Detections": 21837, + "Num Negative": 21283, + "Num Positive": 554, + "Positive %": 2.537, + "Num Positive per mm^2": 220.49 + } +} \ No newline at end of file diff --git a/308/InvasionFront_CD8_block17_x4_y4_patient308_1.json b/308/InvasionFront_CD8_block17_x4_y4_patient308_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ae6e7b25f78fdc99cc405c6f40df71a0e73a895e --- /dev/null +++ b/308/InvasionFront_CD8_block17_x4_y4_patient308_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 10369.5, + "Num Detections": 22861, + "Num Negative": 22446, + "Num Positive": 415, + "Positive %": 1.815, + "Num Positive per mm^2": 154.69 + } +} \ No newline at end of file diff --git a/308/TumorCenter_CD3_block17_x3_y4_patient308_0.json b/308/TumorCenter_CD3_block17_x3_y4_patient308_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8523f3870133bfe40f3e7ad2c75e23d17d1af661 --- /dev/null +++ b/308/TumorCenter_CD3_block17_x3_y4_patient308_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 9919.7, + "Num Detections": 21966, + "Num Negative": 20739, + "Num Positive": 1227, + "Positive %": 5.586, + "Num Positive per mm^2": 455.55 + } +} \ No newline at end of file diff --git a/308/TumorCenter_CD3_block17_x4_y4_patient308_1.json b/308/TumorCenter_CD3_block17_x4_y4_patient308_1.json new file mode 100644 index 0000000000000000000000000000000000000000..72ea18eb20292fb99fb1389b4d97b4acbc8068d8 --- /dev/null +++ b/308/TumorCenter_CD3_block17_x4_y4_patient308_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 9944.7, + "Num Detections": 17730, + "Num Negative": 17494, + "Num Positive": 236, + "Positive %": 1.331, + "Num Positive per mm^2": 93.07 + } +} \ No newline at end of file diff --git a/308/TumorCenter_CD8_block17_x3_y4_patient308_0.json b/308/TumorCenter_CD8_block17_x3_y4_patient308_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3964884a0a4ef530f28c67d2416b8ad2256af8ce --- /dev/null +++ b/308/TumorCenter_CD8_block17_x3_y4_patient308_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 23637.5, + "Num Detections": 21646, + "Num Negative": 21420, + "Num Positive": 226, + "Positive %": 1.044, + "Num Positive per mm^2": 85.85 + } +} \ No newline at end of file diff --git a/308/TumorCenter_CD8_block17_x4_y4_patient308_1.json b/308/TumorCenter_CD8_block17_x4_y4_patient308_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9b1318caf97aea21eb0e0776b3f95198e69b20aa --- /dev/null +++ b/308/TumorCenter_CD8_block17_x4_y4_patient308_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 23587.5, + "Num Detections": 19755, + "Num Negative": 19602, + "Num Positive": 153, + "Positive %": 0.7745, + "Num Positive per mm^2": 61.2 + } +} \ No newline at end of file diff --git a/308/history_text.txt b/308/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/308/icd_codes.txt b/308/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/308/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/308/ops_codes.txt b/308/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5b508f4d896241bc9f7875f26c433bfac8e53f15 --- /dev/null +++ b/308/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] \ No newline at end of file diff --git a/308/patient_clinical_data.json b/308/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9731b92340a493d7c9584a0d644c9be410e22b88 --- /dev/null +++ b/308/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/308/patient_pathological_data.json b/308/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5f542bd11ee6ded771563f55c81e85b14d6da2e0 --- /dev/null +++ b/308/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "308", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + 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