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file mode 100644 index 0000000000000000000000000000000000000000..677b2e6532db5d284f5c9288ade2cf8f1f70406a --- /dev/null +++ b/063/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/063/patient_pathological_data.json b/063/patient_pathological_data.json new file mode 100644 index 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"Positive %": 3.398, + "Num Positive per mm^2": 302.82 + } +} \ No newline at end of file diff --git a/064/TumorCenter_CD3_block3_x4_y1_patient064_1.json b/064/TumorCenter_CD3_block3_x4_y1_patient064_1.json new file mode 100644 index 0000000000000000000000000000000000000000..03a46cccdf03e3c5a359af0cee6303ccccd0a0b7 --- /dev/null +++ b/064/TumorCenter_CD3_block3_x4_y1_patient064_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13710.9, + "Centroid Y µm": 8872.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/064/TumorCenter_CD8_block3_x3_y1_patient064_0.json b/064/TumorCenter_CD8_block3_x3_y1_patient064_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0076267d726ee46abd3ce46b33ceffc6e85d5a35 --- /dev/null +++ b/064/TumorCenter_CD8_block3_x3_y1_patient064_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + 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b/064/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/064/ops_codes.txt b/064/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/064/patient_clinical_data.json b/064/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ea1f2532feb3554812bb48adefd0e20c4abb5fbd --- /dev/null +++ b/064/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + 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@@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6202.6, + "Centroid Y µm": 20429.9, + "Num Detections": 7114, + "Num Negative": 7039, + "Num Positive": 75, + "Positive %": 1.054, + "Num Positive per mm^2": 90.93 + } +} \ No newline at end of file diff --git a/065/InvasionFront_CD8_block11_x2_y4_patient065_1.json b/065/InvasionFront_CD8_block11_x2_y4_patient065_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b8906a8bad8e1e60882f780f8bd95099ae9898c --- /dev/null +++ b/065/InvasionFront_CD8_block11_x2_y4_patient065_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8893.2, + "Centroid Y µm": 20450.5, + "Num Detections": 16948, + "Num Negative": 16426, + "Num Positive": 522, + "Positive %": 3.08, + "Num Positive per mm^2": 226.54 + } +} \ No newline at end of file diff --git a/065/TumorCenter_CD3_block11_x1_y4_patient065_0.json b/065/TumorCenter_CD3_block11_x1_y4_patient065_0.json new file mode 100644 index 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diff --git a/065/TumorCenter_CD8_block11_x1_y4_patient065_0.json b/065/TumorCenter_CD8_block11_x1_y4_patient065_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14b44aad26a650ecb46e619fa7d78774ffbde108 --- /dev/null +++ b/065/TumorCenter_CD8_block11_x1_y4_patient065_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 9869.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/065/TumorCenter_CD8_block11_x2_y4_patient065_1.json b/065/TumorCenter_CD8_block11_x2_y4_patient065_1.json new file mode 100644 index 0000000000000000000000000000000000000000..10000872a9d42c3346c758e16b2fbe98dfa20a40 --- /dev/null +++ b/065/TumorCenter_CD8_block11_x2_y4_patient065_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6871.4, + "Centroid Y µm": 9569.9, + "Num Detections": 6400, + "Num Negative": 6276, + "Num Positive": 124, + "Positive %": 1.938, + "Num Positive per mm^2": 167.33 + } +} \ No newline at end of file diff --git a/065/history_text.txt b/065/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/065/icd_codes.txt b/065/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/065/ops_codes.txt b/065/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/065/patient_clinical_data.json b/065/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e8c9a927f9b86795458c8cfa9a7338615ee4eb2d --- /dev/null +++ b/065/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + 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diff --git a/067/TumorCenter_CD3_block22_x2_y11_patient067_1.json b/067/TumorCenter_CD3_block22_x2_y11_patient067_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6fcda76e88c7419fc2a8aa47b5ac6d52e7e3cb60 --- /dev/null +++ b/067/TumorCenter_CD3_block22_x2_y11_patient067_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6186.7, + "Centroid Y µm": 27493.8, + "Num Detections": 12908, + "Num Negative": 11783, + "Num Positive": 1125, + "Positive %": 8.716, + "Num Positive per mm^2": 568.69 + } +} \ No newline at end of file diff --git a/067/TumorCenter_CD8_block22_x1_y11_patient067_0.json b/067/TumorCenter_CD8_block22_x1_y11_patient067_0.json new file mode 100644 index 0000000000000000000000000000000000000000..119bce1919fc9cdb3de906b833fe2f37c133aeed --- /dev/null +++ b/067/TumorCenter_CD8_block22_x1_y11_patient067_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5622.0, + "Centroid Y µm": 36780.5, + "Num 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--git a/068/InvasionFront_CD3_block8_x4_y2_patient068_1.json b/068/InvasionFront_CD3_block8_x4_y2_patient068_1.json new file mode 100644 index 0000000000000000000000000000000000000000..541940423d2b98b6d23af57cb817bc62de0953aa --- /dev/null +++ b/068/InvasionFront_CD3_block8_x4_y2_patient068_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 15092.0, + "Num Detections": 30017, + "Num Negative": 29377, + "Num Positive": 640, + "Positive %": 2.132, + "Num Positive per mm^2": 220.35 + } +} \ No newline at end of file diff --git a/068/InvasionFront_CD8_block8_x3_y2_patient068_0.json b/068/InvasionFront_CD8_block8_x3_y2_patient068_0.json new file mode 100644 index 0000000000000000000000000000000000000000..40b2fa0c64009166c56b91fabcb742a870f30aec --- /dev/null +++ b/068/InvasionFront_CD8_block8_x3_y2_patient068_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12368.5, + "Centroid Y µm": 5197.2, + "Num 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"Positive %": 8.11, + "Num Positive per mm^2": 793.99 + } +} \ No newline at end of file diff --git a/068/history_text.txt b/068/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/068/icd_codes.txt b/068/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/068/ops_codes.txt b/068/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/068/patient_clinical_data.json b/068/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c46f4a908cc224e991135575f6ea8d51f35731d7 --- /dev/null +++ b/068/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 92, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + 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file mode 100644 index 0000000000000000000000000000000000000000..63dd3fc8390bfaadb622294b0f7bdabaceef55cc --- /dev/null +++ b/069/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 73, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/069/patient_pathological_data.json b/069/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a200f35d4453b8f99798db1073a282056568c678 --- /dev/null +++ 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0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/070/InvasionFront_CD3_block4_x3_y6_patient070_0.json b/070/InvasionFront_CD3_block4_x3_y6_patient070_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4afb8e0c5178500b597b9c13cfeac01d7c4756de --- /dev/null +++ b/070/InvasionFront_CD3_block4_x3_y6_patient070_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 21088.8, + "Num Detections": 18617, + "Num Negative": 17216, + "Num Positive": 1401, + "Positive %": 7.525, + "Num Positive per mm^2": 613.67 + } +} \ No newline at end of file diff --git a/070/InvasionFront_CD3_block4_x4_y6_patient070_1.json b/070/InvasionFront_CD3_block4_x4_y6_patient070_1.json new file mode 100644 index 0000000000000000000000000000000000000000..964f2456fef23a2beaec455b36ad5fc12e4962e0 --- /dev/null +++ b/070/InvasionFront_CD3_block4_x4_y6_patient070_1.json @@ -0,0 +1,11 @@ +{ + 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file diff --git a/070/TumorCenter_CD3_block4_x4_y6_patient070_1.json b/070/TumorCenter_CD3_block4_x4_y6_patient070_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ada40ff58bdcad19913bdd3ed953283472bd1db2 --- /dev/null +++ b/070/TumorCenter_CD3_block4_x4_y6_patient070_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 15341.9, + "Num Detections": 19056, + "Num Negative": 18844, + "Num Positive": 212, + "Positive %": 1.113, + "Num Positive per mm^2": 91.81 + } +} \ No newline at end of file diff --git a/070/TumorCenter_CD8_block4_x3_y6_patient070_0.json b/070/TumorCenter_CD8_block4_x3_y6_patient070_0.json new file mode 100644 index 0000000000000000000000000000000000000000..772f0754a57e80534b59776aebd93e0fc6b91c87 --- /dev/null +++ b/070/TumorCenter_CD8_block4_x3_y6_patient070_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11668.8, + "Centroid Y µm": 15142.0, + "Num Detections": 21537, + "Num Negative": 21018, + "Num Positive": 519, + "Positive %": 2.41, + "Num Positive per mm^2": 227.46 + } +} \ No newline at end of file diff --git a/070/TumorCenter_CD8_block4_x4_y6_patient070_1.json b/070/TumorCenter_CD8_block4_x4_y6_patient070_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e14dc068bd4dc083ed22fe56c493834c26556247 --- /dev/null +++ b/070/TumorCenter_CD8_block4_x4_y6_patient070_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14242.5, + "Centroid Y µm": 15291.9, + "Num Detections": 19632, + "Num Negative": 19580, + "Num Positive": 52, + "Positive %": 0.2649, + "Num Positive per mm^2": 22.9 + } +} \ No newline at end of file diff --git a/070/history_text.txt b/070/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/070/icd_codes.txt b/070/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/070/ops_codes.txt b/070/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/070/patient_clinical_data.json b/070/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..657ccb971aa5c6033462ec1e957eda76e896379e --- /dev/null +++ b/070/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/070/patient_pathological_data.json b/070/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ec2a443e9e12eb8ddc0a20ec0a938cbbe9e2c32b --- /dev/null +++ b/070/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "070", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/070/surgery_description.txt b/070/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/070/surgery_report.txt b/070/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/071/InvasionFront_CD3_block5_x1_y12_patient071_0.json b/071/InvasionFront_CD3_block5_x1_y12_patient071_0.json new file mode 100644 index 0000000000000000000000000000000000000000..67f54a03aa5f38c5940e6306d88bffe288541d3f --- /dev/null +++ b/071/InvasionFront_CD3_block5_x1_y12_patient071_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3230.5, + "Centroid Y µm": 30649.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/071/InvasionFront_CD3_block5_x2_y12_patient071_1.json b/071/InvasionFront_CD3_block5_x2_y12_patient071_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a24e101b74ecba4efca218da475a5c68463168fa --- /dev/null +++ b/071/InvasionFront_CD3_block5_x2_y12_patient071_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 30383.9, + "Num Detections": 15877, + "Num Negative": 14733, + "Num Positive": 1144, + "Positive %": 7.205, + "Num Positive per mm^2": 539.67 + } +} \ No newline at end of file diff --git a/071/InvasionFront_CD8_block5_x1_y10_patient071_0.json b/071/InvasionFront_CD8_block5_x1_y10_patient071_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d26c52ee0a6a60075ebbbbcc21a23334e7fccc6b --- /dev/null +++ b/071/InvasionFront_CD8_block5_x1_y10_patient071_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 25261.6, + "Num Detections": 22574, + "Num Negative": 22386, + "Num Positive": 188, + "Positive %": 0.8328, + "Num Positive per mm^2": 73.96 + } +} \ No newline at end of file diff --git a/071/InvasionFront_CD8_block5_x2_y10_patient071_1.json b/071/InvasionFront_CD8_block5_x2_y10_patient071_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6b897821448442a9c0c3341b5c104048bcf1962e --- /dev/null +++ b/071/InvasionFront_CD8_block5_x2_y10_patient071_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 25236.6, + "Num Detections": 17566, + "Num Negative": 17258, + "Num Positive": 308, + "Positive %": 1.753, + "Num Positive per mm^2": 132.41 + } +} \ No newline at end of file diff --git a/071/TumorCenter_CD3_block5_x1_y10_patient071_0.json b/071/TumorCenter_CD3_block5_x1_y10_patient071_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c78990df1114a4cef1eed2abf473c6c98997abd9 --- /dev/null +++ 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"Positive %": 1.041, + "Num Positive per mm^2": 75.5 + } +} \ No newline at end of file diff --git a/071/history_text.txt b/071/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/071/icd_codes.txt b/071/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/071/ops_codes.txt b/071/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/071/patient_clinical_data.json b/071/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d0b20585ea4b9cfa2003a6b0ae3144115bfb2d1a --- /dev/null +++ b/071/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/071/patient_pathological_data.json b/071/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1b6db9a65785d906f11951c4233c83d38e71b481 --- /dev/null +++ b/071/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "071", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, 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0000000000000000000000000000000000000000..d41b5e4afc8a920d67802dd1627211c738fd4676 --- /dev/null +++ b/072/InvasionFront_CD3_block10_x5_y5_patient072_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 18290.3, + "Num Detections": 22293, + "Num Negative": 19737, + "Num Positive": 2556, + "Positive %": 11.47, + "Num Positive per mm^2": 1011.1 + } +} \ No newline at end of file diff --git a/072/InvasionFront_CD3_block10_x6_y5_patient072_1.json b/072/InvasionFront_CD3_block10_x6_y5_patient072_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e9248b838f3647ab8d3e536ae5c98507139d660a --- /dev/null +++ b/072/InvasionFront_CD3_block10_x6_y5_patient072_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21288.7, + "Centroid Y µm": 18790.1, + "Num Detections": 22625, + "Num Negative": 20456, + "Num Positive": 2169, + "Positive %": 9.587, + "Num Positive per mm^2": 871.11 + } +} \ No newline at end of file diff --git a/072/InvasionFront_CD8_block10_x5_y5_patient072_0.json b/072/InvasionFront_CD8_block10_x5_y5_patient072_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e42e68a8da17847869f91b94bb4afe8fa2b5677c --- /dev/null +++ b/072/InvasionFront_CD8_block10_x5_y5_patient072_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17940.5, + "Centroid Y µm": 18290.3, + "Num Detections": 20037, + "Num Negative": 19567, + "Num Positive": 470, + "Positive %": 2.346, + "Num Positive per mm^2": 199.72 + } +} \ No newline at end of file diff --git a/072/InvasionFront_CD8_block10_x6_y5_patient072_1.json b/072/InvasionFront_CD8_block10_x6_y5_patient072_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd54ee7087ec03df69320ddbfb04cec05f6b423c --- /dev/null +++ b/072/InvasionFront_CD8_block10_x6_y5_patient072_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20564.1, + "Centroid Y µm": 18565.2, + "Num Detections": 20115, + "Num Negative": 19476, + "Num Positive": 639, + "Positive %": 3.177, + "Num Positive per mm^2": 297.3 + } +} \ No newline at end of file diff --git a/072/TumorCenter_CD3_block10_x5_y5_patient072_0.json b/072/TumorCenter_CD3_block10_x5_y5_patient072_0.json new file mode 100644 index 0000000000000000000000000000000000000000..116b9762afcd960791145999eb3221dad0bad4ec --- /dev/null +++ b/072/TumorCenter_CD3_block10_x5_y5_patient072_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 12318.5, + "Num Detections": 20353, + "Num Negative": 18944, + "Num Positive": 1409, + "Positive %": 6.923, + "Num Positive per mm^2": 612.35 + } +} \ No newline at end of file diff --git a/072/TumorCenter_CD3_block10_x6_y5_patient072_1.json b/072/TumorCenter_CD3_block10_x6_y5_patient072_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e48f4c17ed55ef10864460695fa2948a5943425 --- /dev/null +++ b/072/TumorCenter_CD3_block10_x6_y5_patient072_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21563.6, + "Centroid Y µm": 12268.5, + "Num Detections": 17308, + "Num Negative": 16235, + "Num Positive": 1073, + "Positive %": 6.199, + "Num Positive per mm^2": 461.41 + } +} \ No newline at end of file diff --git a/072/TumorCenter_CD8_block10_x5_y5_patient072_0.json b/072/TumorCenter_CD8_block10_x5_y5_patient072_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c7d50f4377a1895d68d9434dbc38ec6016f38458 --- /dev/null +++ b/072/TumorCenter_CD8_block10_x5_y5_patient072_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16166.4, + "Centroid Y µm": 12818.2, + "Num Detections": 22076, + "Num Negative": 19133, + "Num Positive": 2943, + "Positive %": 13.33, + "Num Positive per mm^2": 1163.2 + } +} \ No newline at end of file diff --git a/072/TumorCenter_CD8_block10_x6_y5_patient072_1.json 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diff --git a/072/patient_clinical_data.json b/072/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..01e3ba3e47c5b4a6f0580da0e06530515ae6dcd4 --- /dev/null +++ b/072/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 53, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 45, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/072/patient_pathological_data.json b/072/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f7a397689d96fc0faab9d559bf71944121c5a2d2 --- /dev/null +++ b/072/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "072", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/072/surgery_description.txt b/072/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/072/surgery_report.txt b/072/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/073/InvasionFront_CD3_block11_x5_y3_patient073_0.json b/073/InvasionFront_CD3_block11_x5_y3_patient073_0.json new file mode 100644 index 0000000000000000000000000000000000000000..39173dfd870be9236c1b94776cc26332540ef5e4 --- /dev/null +++ b/073/InvasionFront_CD3_block11_x5_y3_patient073_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15441.8, + "Centroid Y µm": 7346.1, + "Num Detections": 16583, + "Num Negative": 15110, + "Num Positive": 1473, + "Positive %": 8.883, + "Num Positive per mm^2": 705.23 + } +} \ No newline at end of file diff --git a/073/InvasionFront_CD3_block11_x6_y3_patient073_1.json b/073/InvasionFront_CD3_block11_x6_y3_patient073_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6cc79d58e0076d0aed2d180705a70309cdaadcbf --- /dev/null +++ b/073/InvasionFront_CD3_block11_x6_y3_patient073_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 7296.1, + "Num Detections": 16022, + "Num Negative": 14807, + "Num Positive": 1215, + "Positive %": 7.583, + "Num Positive per mm^2": 675.95 + } +} \ No newline at end of file diff --git a/073/InvasionFront_CD8_block11_x5_y3_patient073_0.json b/073/InvasionFront_CD8_block11_x5_y3_patient073_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c5a51c54224a7db62cd01d07836134af97063398 --- /dev/null +++ b/073/InvasionFront_CD8_block11_x5_y3_patient073_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18643.5, + "Centroid Y µm": 18113.1, + "Num Detections": 10885, + "Num Negative": 10098, + "Num Positive": 787, + "Positive %": 7.23, + "Num Positive per mm^2": 571.54 + } +} \ No newline at end of file diff --git a/073/InvasionFront_CD8_block11_x6_y3_patient073_1.json b/073/InvasionFront_CD8_block11_x6_y3_patient073_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e5520325f6454452c95c28807938d20f1b1445bb --- /dev/null +++ b/073/InvasionFront_CD8_block11_x6_y3_patient073_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21185.0, + "Centroid Y µm": 18170.5, + "Num Detections": 8047, + "Num Negative": 7782, + "Num Positive": 265, + "Positive %": 3.293, + "Num Positive per mm^2": 262.14 + } +} \ No newline at end of file diff --git a/073/TumorCenter_CD3_block11_x5_y3_patient073_0.json b/073/TumorCenter_CD3_block11_x5_y3_patient073_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8339e3ac398fc8524ad56719d6017c6645400d73 --- /dev/null +++ b/073/TumorCenter_CD3_block11_x5_y3_patient073_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19539.7, + "Centroid Y µm": 7646.0, + "Num Detections": 20800, + "Num Negative": 13986, + "Num Positive": 6814, + "Positive %": 32.76, + "Num Positive per mm^2": 2941.5 + } +} \ No newline at end of file diff --git a/073/TumorCenter_CD3_block11_x6_y3_patient073_1.json b/073/TumorCenter_CD3_block11_x6_y3_patient073_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cbccf20ab3d895c5d781e162571da7a3ea1d7b2e --- /dev/null +++ b/073/TumorCenter_CD3_block11_x6_y3_patient073_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 22013.3, + "Centroid Y µm": 7770.9, + "Num Detections": 19822, + "Num Negative": 15244, + "Num Positive": 4578, + "Positive %": 23.1, + "Num Positive per mm^2": 2019.9 + } +} \ No newline at end of file diff --git a/073/TumorCenter_CD8_block11_x5_y3_patient073_0.json b/073/TumorCenter_CD8_block11_x5_y3_patient073_0.json new file mode 100644 index 0000000000000000000000000000000000000000..879ab65c016b251c2a01662a28abed17ca824a3c --- /dev/null +++ b/073/TumorCenter_CD8_block11_x5_y3_patient073_0.json @@ -0,0 +1,11 @@ +{ + 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--git a/073/icd_codes.txt b/073/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/073/ops_codes.txt b/073/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/073/patient_clinical_data.json b/073/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a72f5c9d3aaee0c16f5c18ab71d0760d2120debc --- /dev/null +++ b/073/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + 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"Positive %": 8.572, + "Num Positive per mm^2": 728.99 + } +} \ No newline at end of file diff --git a/074/InvasionFront_CD3_block2_x2_y9_patient074_1.json b/074/InvasionFront_CD3_block2_x2_y9_patient074_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6a1e278d155ca49037a3dea0aded27ee6d6ba170 --- /dev/null +++ b/074/InvasionFront_CD3_block2_x2_y9_patient074_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8770.4, + "Centroid Y µm": 35656.1, + "Num Detections": 23689, + "Num Negative": 21948, + "Num Positive": 1741, + "Positive %": 7.349, + "Num Positive per mm^2": 629.21 + } +} \ No newline at end of file diff --git a/074/InvasionFront_CD8_block2_x1_y9_patient074_0.json b/074/InvasionFront_CD8_block2_x1_y9_patient074_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c531d6047eb24a5d72876cd5b9d7686c6efb4718 --- /dev/null +++ b/074/InvasionFront_CD8_block2_x1_y9_patient074_0.json @@ -0,0 +1,11 @@ +{ + 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diff --git a/074/TumorCenter_CD8_block2_x1_y9_patient074_0.json b/074/TumorCenter_CD8_block2_x1_y9_patient074_0.json new file mode 100644 index 0000000000000000000000000000000000000000..544d9e6d59bcfc8a577877b6cd1257c97bec219b --- /dev/null +++ b/074/TumorCenter_CD8_block2_x1_y9_patient074_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5821.9, + "Centroid Y µm": 22213.2, + "Num Detections": 24225, + "Num Negative": 23315, + "Num Positive": 910, + "Positive %": 3.756, + "Num Positive per mm^2": 336.06 + } +} \ No newline at end of file diff --git a/074/TumorCenter_CD8_block2_x2_y9_patient074_1.json b/074/TumorCenter_CD8_block2_x2_y9_patient074_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eff44f85096e220e07138f323e00986984342e44 --- /dev/null +++ b/074/TumorCenter_CD8_block2_x2_y9_patient074_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8470.5, + "Centroid Y µm": 22188.3, + "Num Detections": 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0000000000000000000000000000000000000000..029ef835bf4089b482f9140524fcf436ddb32ed1 --- /dev/null +++ b/075/InvasionFront_CD3_block9_x3_y7_patient075_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12493.4, + "Centroid Y µm": 18190.4, + "Num Detections": 22698, + "Num Negative": 20720, + "Num Positive": 1978, + "Positive %": 8.714, + "Num Positive per mm^2": 739.99 + } +} \ No newline at end of file diff --git a/075/InvasionFront_CD3_block9_x4_y7_patient075_1.json b/075/InvasionFront_CD3_block9_x4_y7_patient075_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3577330f278197d8cbd18dbcd47d6ff2a7c81283 --- /dev/null +++ b/075/InvasionFront_CD3_block9_x4_y7_patient075_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15042.0, + "Centroid Y µm": 18440.2, + "Num Detections": 21627, + "Num Negative": 20344, + "Num Positive": 1283, + "Positive %": 5.932, + "Num Positive per mm^2": 485.8 + } +} \ No newline at end of file diff --git a/075/InvasionFront_CD8_block9_x3_y7_patient075_0.json b/075/InvasionFront_CD8_block9_x3_y7_patient075_0.json new file mode 100644 index 0000000000000000000000000000000000000000..264a47c6a98b9437fbc834273bffcb75bb4b66b2 --- /dev/null +++ b/075/InvasionFront_CD8_block9_x3_y7_patient075_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12468.4, + "Centroid Y µm": 21938.4, + "Num Detections": 23345, + "Num Negative": 21006, + "Num Positive": 2339, + "Positive %": 10.02, + "Num Positive per mm^2": 890.16 + } +} \ No newline at end of file diff --git a/075/InvasionFront_CD8_block9_x4_y7_patient075_1.json b/075/InvasionFront_CD8_block9_x4_y7_patient075_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2fc696a35a7fe74c5cabd74a4f93053f08baf4da --- /dev/null +++ b/075/InvasionFront_CD8_block9_x4_y7_patient075_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15017.0, + "Centroid Y µm": 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b/075/TumorCenter_CD3_block9_x4_y7_patient075_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 23212.7, + "Num Detections": 23704, + "Num Negative": 22774, + "Num Positive": 930, + "Positive %": 3.923, + "Num Positive per mm^2": 337.7 + } +} \ No newline at end of file diff --git a/075/TumorCenter_CD8_block9_x3_y7_patient075_0.json b/075/TumorCenter_CD8_block9_x3_y7_patient075_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b1ff0c87ada9f214e08250f9eef7c3ef6d1f6d21 --- /dev/null +++ b/075/TumorCenter_CD8_block9_x3_y7_patient075_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11419.0, + "Centroid Y µm": 18515.2, + "Num Detections": 20481, + "Num Negative": 17304, + "Num Positive": 3177, + "Positive %": 15.51, + "Num Positive per mm^2": 1323.8 + } +} \ No newline at end of file diff --git a/075/TumorCenter_CD8_block9_x4_y7_patient075_1.json b/075/TumorCenter_CD8_block9_x4_y7_patient075_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7d54b7f0473879c612b80656cfc657fa6c605c24 --- /dev/null +++ b/075/TumorCenter_CD8_block9_x4_y7_patient075_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 18440.2, + "Num Detections": 23082, + "Num Negative": 22332, + "Num Positive": 750, + "Positive %": 3.249, + "Num Positive per mm^2": 277.15 + } +} \ No newline at end of file diff --git a/075/history_text.txt b/075/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/075/icd_codes.txt b/075/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/075/ops_codes.txt b/075/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/075/patient_clinical_data.json b/075/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..469ab8b8d26eb3eb63bbc8ce3d28329e271755c7 --- /dev/null +++ b/075/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 32, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/075/patient_pathological_data.json b/075/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..34da8da983905da8be4cfc4042f6d7cfa965220e --- /dev/null +++ b/075/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "075", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 18.0 +} \ No newline at end of file diff --git a/075/surgery_description.txt b/075/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/075/surgery_report.txt b/075/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/076/InvasionFront_CD3_block22_x3_y8_patient076_0.json b/076/InvasionFront_CD3_block22_x3_y8_patient076_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2dbc93c439ce1e529f90b7ffe3f0aa15b58f959a --- /dev/null +++ b/076/InvasionFront_CD3_block22_x3_y8_patient076_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12105.3, + "Centroid Y µm": 31488.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/076/InvasionFront_CD3_block22_x4_y8_patient076_1.json b/076/InvasionFront_CD3_block22_x4_y8_patient076_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65e36355c51ab1795de5efd349298ed16caebb62 --- /dev/null +++ b/076/InvasionFront_CD3_block22_x4_y8_patient076_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14517.3, + "Centroid Y µm": 31558.3, + "Num Detections": 13935, + "Num Negative": 11760, + "Num Positive": 2175, + "Positive %": 15.61, + "Num Positive per mm^2": 1357.0 + } +} \ No newline at end of file diff --git a/076/InvasionFront_CD8_block22_x3_y8_patient076_0.json b/076/InvasionFront_CD8_block22_x3_y8_patient076_0.json new file mode 100644 index 0000000000000000000000000000000000000000..51966d097bba89c9937e57f6b64d18802777540f --- /dev/null +++ b/076/InvasionFront_CD8_block22_x3_y8_patient076_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14603.4, + "Centroid Y µm": 19771.6, + "Num Detections": 10433, + "Num Negative": 9954, + "Num Positive": 479, + "Positive %": 4.591, + "Num Positive per mm^2": 328.81 + } +} \ No newline at end of file diff --git a/076/InvasionFront_CD8_block22_x4_y8_patient076_1.json 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+ "Positive %": 37.19, + "Num Positive per mm^2": 3320.6 + } +} \ No newline at end of file diff --git a/076/TumorCenter_CD3_block22_x4_y8_patient076_1.json b/076/TumorCenter_CD3_block22_x4_y8_patient076_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9dfd238c7dc65f60e12d7f184798325eff5d49fc --- /dev/null +++ b/076/TumorCenter_CD3_block22_x4_y8_patient076_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14167.5, + "Centroid Y µm": 20339.2, + "Num Detections": 19519, + "Num Negative": 10033, + "Num Positive": 9486, + "Positive %": 48.6, + "Num Positive per mm^2": 4367.2 + } +} \ No newline at end of file diff --git a/076/TumorCenter_CD8_block22_x3_y8_patient076_0.json b/076/TumorCenter_CD8_block22_x3_y8_patient076_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e53f0898d247dc4b62167fd654ea8d4722fa7d7a --- /dev/null +++ b/076/TumorCenter_CD8_block22_x3_y8_patient076_0.json @@ -0,0 +1,11 @@ +{ + 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diff --git a/076/icd_codes.txt b/076/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/076/ops_codes.txt b/076/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/076/patient_clinical_data.json b/076/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0c4d564804dd8a3170ad4e9ab9a3b7a2fbde7425 --- /dev/null +++ b/076/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 75, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 52, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": 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17.87, + "Num Positive per mm^2": 1681.7 + } +} \ No newline at end of file diff --git a/077/InvasionFront_CD3_block7_x2_y9_patient077_1.json b/077/InvasionFront_CD3_block7_x2_y9_patient077_1.json new file mode 100644 index 0000000000000000000000000000000000000000..014ea6ecd31efccdfa3b14c11eaf8162f9cd4d1e --- /dev/null +++ b/077/InvasionFront_CD3_block7_x2_y9_patient077_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 22013.3, + "Num Detections": 30270, + "Num Negative": 28228, + "Num Positive": 2042, + "Positive %": 6.746, + "Num Positive per mm^2": 776.81 + } +} \ No newline at end of file diff --git a/077/InvasionFront_CD8_block7_x1_y9_patient077_0.json b/077/InvasionFront_CD8_block7_x1_y9_patient077_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e07c3e929dd2b78b634498f55890a086d256801b --- /dev/null +++ b/077/InvasionFront_CD8_block7_x1_y9_patient077_0.json @@ -0,0 +1,11 @@ +{ + 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0000000000000000000000000000000000000000..c0081e84ff61fc47b7c3068d34fe11ea9ae096f6 --- /dev/null +++ b/077/TumorCenter_CD3_block7_x1_y9_patient077_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3423.2, + "Centroid Y µm": 22638.0, + "Num Detections": 23323, + "Num Negative": 18895, + "Num Positive": 4428, + "Positive %": 18.99, + "Num Positive per mm^2": 1822.7 + } +} \ No newline at end of file diff --git a/077/TumorCenter_CD3_block7_x2_y9_patient077_1.json b/077/TumorCenter_CD3_block7_x2_y9_patient077_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9dbd28911b66e4a4248eeb9ceb35e63a21ddf4b --- /dev/null +++ b/077/TumorCenter_CD3_block7_x2_y9_patient077_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 22738.0, + "Num Detections": 27893, + "Num Negative": 24130, + "Num Positive": 3763, + "Positive %": 13.49, + "Num Positive per mm^2": 1338.5 + } +} \ No newline at end of file diff --git a/077/TumorCenter_CD8_block7_x1_y9_patient077_0.json b/077/TumorCenter_CD8_block7_x1_y9_patient077_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c6ce3e4864a78314bb33c7a92bf028e4950f733d --- /dev/null +++ b/077/TumorCenter_CD8_block7_x1_y9_patient077_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3223.3, + "Centroid Y µm": 22538.1, + "Num Detections": 30797, + "Num Negative": 29760, + "Num Positive": 1037, + "Positive %": 3.367, + "Num Positive per mm^2": 387.66 + } +} \ No newline at end of file diff --git a/077/TumorCenter_CD8_block7_x2_y9_patient077_1.json b/077/TumorCenter_CD8_block7_x2_y9_patient077_1.json new file mode 100644 index 0000000000000000000000000000000000000000..33981163e57ae57dd937650c537d048a1ac4c767 --- /dev/null +++ b/077/TumorCenter_CD8_block7_x2_y9_patient077_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 22588.0, + "Num Detections": 34806, + "Num Negative": 33619, + "Num Positive": 1187, + "Positive %": 3.41, + "Num Positive per mm^2": 423.71 + } +} \ No newline at end of file diff --git a/077/history_text.txt b/077/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/077/icd_codes.txt b/077/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/077/ops_codes.txt b/077/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/077/patient_clinical_data.json b/077/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8e683b96cc90dab8792b6a50af1aabdd70dceaa7 --- /dev/null +++ b/077/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 47, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/077/patient_pathological_data.json b/077/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..617549788daf49d9a0593ecea853f2db7c162e1c --- /dev/null +++ b/077/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "077", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "hpv_association_p16", + 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index 0000000000000000000000000000000000000000..19fc355d1b56c7d6e4ef0603022a055d1bafc182 --- /dev/null +++ b/078/InvasionFront_CD8_block5_x5_y11_patient078_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 27485.4, + "Num Detections": 20824, + "Num Negative": 19670, + "Num Positive": 1154, + "Positive %": 5.542, + "Num Positive per mm^2": 496.22 + } +} \ No newline at end of file diff --git a/078/InvasionFront_CD8_block5_x6_y11_patient078_1.json b/078/InvasionFront_CD8_block5_x6_y11_patient078_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f6e9c7c129e7326431fd6eb38a630e718182b99b --- /dev/null +++ b/078/InvasionFront_CD8_block5_x6_y11_patient078_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 27485.4, + "Num Detections": 22276, + "Num Negative": 21647, + "Num Positive": 629, + "Positive %": 2.824, + "Num Positive per mm^2": 281.28 + } +} \ No newline at end of file diff --git a/078/TumorCenter_CD3_block5_x5_y11_patient078_0.json b/078/TumorCenter_CD3_block5_x5_y11_patient078_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3226f60ae37157b187b688dba5761a2236c44800 --- /dev/null +++ b/078/TumorCenter_CD3_block5_x5_y11_patient078_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15691.7, + "Centroid Y µm": 27785.3, + "Num Detections": 19775, + "Num Negative": 11277, + "Num Positive": 8498, + "Positive %": 42.97, + "Num Positive per mm^2": 3623.6 + } +} \ No newline at end of file diff --git a/078/TumorCenter_CD3_block5_x6_y11_patient078_1.json b/078/TumorCenter_CD3_block5_x6_y11_patient078_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b9468c7b1f56a19a3990530a1cbbee5495ca8814 --- /dev/null +++ b/078/TumorCenter_CD3_block5_x6_y11_patient078_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18090.4, + "Centroid Y µm": 28085.1, + "Num Detections": 19768, + "Num Negative": 16360, + "Num Positive": 3408, + "Positive %": 17.24, + "Num Positive per mm^2": 1579.0 + } +} \ No newline at end of file diff --git a/078/TumorCenter_CD8_block5_x5_y11_patient078_0.json b/078/TumorCenter_CD8_block5_x5_y11_patient078_0.json new file mode 100644 index 0000000000000000000000000000000000000000..69b6d62d81dadd18ae998e4a3066662c94d62e72 --- /dev/null +++ b/078/TumorCenter_CD8_block5_x5_y11_patient078_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 27685.3, + "Num Detections": 17571, + "Num Negative": 11062, + "Num Positive": 6509, + "Positive %": 37.04, + "Num Positive per mm^2": 2954.2 + } +} \ No newline at end of file diff --git a/078/TumorCenter_CD8_block5_x6_y11_patient078_1.json b/078/TumorCenter_CD8_block5_x6_y11_patient078_1.json new file mode 100644 index 0000000000000000000000000000000000000000..77c620d34540627f4b3710a4e03bf39f45520db6 --- /dev/null +++ b/078/TumorCenter_CD8_block5_x6_y11_patient078_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 27710.3, + "Num Detections": 16749, + "Num Negative": 14591, + "Num Positive": 2158, + "Positive %": 12.88, + "Num Positive per mm^2": 1131.6 + } +} \ No newline at end of file diff --git a/078/history_text.txt b/078/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/078/icd_codes.txt b/078/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/078/ops_codes.txt b/078/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/078/patient_clinical_data.json b/078/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1aca7f7ccd0379bcff24252759fe04e1a1ae33fe --- /dev/null +++ b/078/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 7, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/078/patient_pathological_data.json b/078/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cff6c4f65b5949601de44dc99cce1213c043b448 --- /dev/null +++ b/078/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "078", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 10.0, + "number_of_resected_lymph_nodes": 34, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.6", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/078/surgery_description.txt b/078/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/078/surgery_report.txt b/078/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/079/InvasionFront_CD3_block22_x3_y4_patient079_0.json b/079/InvasionFront_CD3_block22_x3_y4_patient079_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9fccf0482af0654d68621695908d5b0670a6c27c --- /dev/null +++ b/079/InvasionFront_CD3_block22_x3_y4_patient079_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12268.5, + "Centroid Y µm": 21488.6, + "Num Detections": 17982, + "Num Negative": 11685, + "Num Positive": 6297, + "Positive %": 35.02, + "Num Positive per mm^2": 2832.4 + } +} \ No newline at end of file diff --git a/079/InvasionFront_CD3_block22_x4_y4_patient079_1.json b/079/InvasionFront_CD3_block22_x4_y4_patient079_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a27db4d28d451afb7194575c48e4eff49697dce9 --- /dev/null +++ b/079/InvasionFront_CD3_block22_x4_y4_patient079_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14617.3, + "Centroid Y µm": 21538.6, + "Num Detections": 17777, + "Num Negative": 13049, + "Num Positive": 4728, + "Positive %": 26.6, + "Num Positive per mm^2": 2179.8 + } +} \ No newline at end of file diff --git a/079/InvasionFront_CD8_block22_x3_y4_patient079_0.json b/079/InvasionFront_CD8_block22_x3_y4_patient079_0.json new file mode 100644 index 0000000000000000000000000000000000000000..85c94b729a602fdf0c2ff64047a5be18938f13f8 --- /dev/null +++ b/079/InvasionFront_CD8_block22_x3_y4_patient079_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14242.5, + "Centroid Y µm": 10169.6, + "Num Detections": 18258, + "Num Negative": 14069, + "Num Positive": 4189, + "Positive %": 22.94, + "Num Positive per mm^2": 1918.2 + } +} \ No newline at end of file diff --git a/079/InvasionFront_CD8_block22_x4_y4_patient079_1.json b/079/InvasionFront_CD8_block22_x4_y4_patient079_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0e83e29717d50b0f0de0020dd7bc298d04ca755f --- /dev/null +++ b/079/InvasionFront_CD8_block22_x4_y4_patient079_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 10069.7, + "Num Detections": 17592, + "Num Negative": 14675, + "Num Positive": 2917, + "Positive %": 16.58, + "Num Positive per mm^2": 1381.5 + } +} \ No newline at end of file diff --git a/079/TumorCenter_CD3_block22_x3_y4_patient079_0.json b/079/TumorCenter_CD3_block22_x3_y4_patient079_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0141db4b9f0d1cc1e349d5d2afa85fa9318cc613 --- /dev/null +++ b/079/TumorCenter_CD3_block22_x3_y4_patient079_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11918.7, + "Centroid Y µm": 10744.3, + "Num Detections": 19695, + "Num Negative": 16258, + "Num Positive": 3437, + "Positive %": 17.45, + "Num Positive per mm^2": 1567.2 + } +} \ No newline at end of file diff --git a/079/TumorCenter_CD3_block22_x4_y4_patient079_1.json b/079/TumorCenter_CD3_block22_x4_y4_patient079_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4453d3530506ed93e601552969a1f081bf4ee92d --- /dev/null +++ b/079/TumorCenter_CD3_block22_x4_y4_patient079_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 10844.3, + "Num Detections": 16825, + "Num Negative": 14998, + "Num Positive": 1827, + "Positive %": 10.86, + "Num Positive per mm^2": 905.51 + } +} \ No newline at end of file diff --git a/079/TumorCenter_CD8_block22_x3_y4_patient079_0.json b/079/TumorCenter_CD8_block22_x3_y4_patient079_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f3897610ea17f256b0f6ae6255d8ee7e15c5e322 --- /dev/null +++ b/079/TumorCenter_CD8_block22_x3_y4_patient079_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14192.5, + "Centroid Y µm": 19864.5, + "Num Detections": 18914, + "Num Negative": 17614, + "Num Positive": 1300, + "Positive %": 6.873, + "Num Positive per mm^2": 609.18 + } +} \ No newline at end of file diff --git a/079/TumorCenter_CD8_block22_x4_y4_patient079_1.json b/079/TumorCenter_CD8_block22_x4_y4_patient079_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aafd5457bdf79aedd38de96a109c9391b2a273c7 --- /dev/null +++ b/079/TumorCenter_CD8_block22_x4_y4_patient079_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 19939.4, + "Num Detections": 16732, + "Num Negative": 15267, + "Num Positive": 1465, + "Positive %": 8.756, + "Num Positive per mm^2": 728.73 + } +} \ No newline at end of file diff --git a/079/history_text.txt b/079/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/079/icd_codes.txt b/079/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/079/ops_codes.txt b/079/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/079/patient_clinical_data.json b/079/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..224c7a05adcdc14df5a9d470e33a86b705baa189 --- /dev/null +++ b/079/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 53, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/079/patient_pathological_data.json b/079/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..66e3c99cac87767f2a91dcba9c5aa8369fde21f6 --- /dev/null +++ b/079/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "079", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 23, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/079/surgery_description.txt b/079/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/079/surgery_report.txt b/079/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/080/InvasionFront_CD3_block17_x5_y2_patient080_0.json b/080/InvasionFront_CD3_block17_x5_y2_patient080_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6b7888170625595821ddbd5a3b8a36982514ba3e --- /dev/null +++ b/080/InvasionFront_CD3_block17_x5_y2_patient080_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 10144.6, + "Num Detections": 18742, + "Num Negative": 17496, + "Num Positive": 1246, + "Positive %": 6.648, + "Num Positive per mm^2": 510.99 + } +} \ No newline at end of file diff --git a/080/InvasionFront_CD3_block17_x6_y2_patient080_1.json b/080/InvasionFront_CD3_block17_x6_y2_patient080_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fb0e5dfbcc9ca75b2528d9e7ece1b938e2910aeb --- /dev/null +++ b/080/InvasionFront_CD3_block17_x6_y2_patient080_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 10119.6, + "Num Detections": 21240, + "Num Negative": 18413, + "Num Positive": 2827, + "Positive %": 13.31, + "Num Positive per mm^2": 1105.0 + } +} \ No newline at end of file diff --git a/080/InvasionFront_CD8_block17_x5_y2_patient080_0.json b/080/InvasionFront_CD8_block17_x5_y2_patient080_0.json new file mode 100644 index 0000000000000000000000000000000000000000..68d6358dc550121e24a1fab385206b9d4c7b6f5b --- /dev/null +++ b/080/InvasionFront_CD8_block17_x5_y2_patient080_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 5247.2, + "Num Detections": 16835, + "Num Negative": 15316, + "Num Positive": 1519, + "Positive %": 9.023, + "Num Positive per mm^2": 629.52 + } +} \ No newline at end of file diff --git a/080/InvasionFront_CD8_block17_x6_y2_patient080_1.json b/080/InvasionFront_CD8_block17_x6_y2_patient080_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7323d93bdb649b7bc97eea1c4608d1eb92cb1d51 --- /dev/null +++ b/080/InvasionFront_CD8_block17_x6_y2_patient080_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 5272.2, + "Num Detections": 18685, + "Num Negative": 12882, + "Num Positive": 5803, + "Positive %": 31.06, + "Num Positive per mm^2": 2311.8 + } +} \ No newline at end of file diff --git a/080/TumorCenter_CD3_block17_x5_y2_patient080_0.json b/080/TumorCenter_CD3_block17_x5_y2_patient080_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f99889bf3569b87ca68f89276d46575496a5e675 --- /dev/null +++ b/080/TumorCenter_CD3_block17_x5_y2_patient080_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 5022.3, + "Num Detections": 21151, + "Num Negative": 20203, + "Num Positive": 948, + "Positive %": 4.482, + "Num Positive per mm^2": 408.16 + } +} \ No newline at end of file diff --git a/080/TumorCenter_CD3_block17_x6_y2_patient080_1.json b/080/TumorCenter_CD3_block17_x6_y2_patient080_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c810f302c57ec7487ed207cd55fc7fcf3b1002a6 --- /dev/null +++ b/080/TumorCenter_CD3_block17_x6_y2_patient080_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 5047.3, + "Num Detections": 19547, + "Num Negative": 17490, + "Num Positive": 2057, + "Positive %": 10.52, + "Num Positive per mm^2": 846.22 + } +} \ No newline at end of file diff --git a/080/TumorCenter_CD8_block17_x5_y2_patient080_0.json b/080/TumorCenter_CD8_block17_x5_y2_patient080_0.json new file mode 100644 index 0000000000000000000000000000000000000000..474fa3484f8c12409c4ce1d1676fb17436d18a83 --- /dev/null +++ b/080/TumorCenter_CD8_block17_x5_y2_patient080_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18727.6, + "Centroid Y µm": 18452.7, + "Num Detections": 19877, + "Num Negative": 19475, + "Num Positive": 402, + "Positive %": 2.022, + "Num Positive per mm^2": 180.68 + } +} \ No newline at end of file diff --git a/080/TumorCenter_CD8_block17_x6_y2_patient080_1.json b/080/TumorCenter_CD8_block17_x6_y2_patient080_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7b5b42bbe7c2abf9dbb85cf5e71066d7e8a00ae2 --- /dev/null +++ b/080/TumorCenter_CD8_block17_x6_y2_patient080_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21251.2, + "Centroid Y µm": 18565.2, + "Num Detections": 18419, + "Num Negative": 16514, + "Num Positive": 1905, + "Positive %": 10.34, + "Num Positive per mm^2": 786.67 + } +} \ No newline at end of file diff --git a/080/history_text.txt b/080/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..018c0324e757a03370cfb463b9720830aa59b627 --- /dev/null +++ b/080/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed glottic squamous cell carcinoma on both sides. Primary external surgery already recommended during panendoscopy.final histology and then discussion in the interdisciplinary tumor conference. Plan closure of tracheostoma at intervals. \ No newline at end of file diff --git a/080/icd_codes.txt b/080/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10623317f12e2cf8eb61e998e27f4b464b164dc5 --- /dev/null +++ b/080/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] \ No newline at end of file diff --git a/080/ops_codes.txt b/080/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3998c87bc780e2f7195781b898ef419ce2886b22 --- /dev/null +++ b/080/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/080/patient_clinical_data.json b/080/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..06d64b788bc0153dccdf7b06326453f21dece9c7 --- /dev/null +++ b/080/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 30, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/080/patient_pathological_data.json b/080/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d09622cf86c39f978a6a5cc86a97a4b0cd978466 --- /dev/null +++ b/080/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "080", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/080/surgery_description.txt b/080/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1542eb16b2652f51e333d02e902fe76ed8579659 --- /dev/null +++ b/080/surgery_description.txt @@ -0,0 +1 @@ +Modified Leroux-Robert partial laryngeal resection, Tracheostomy diff --git a/080/surgery_report.txt b/080/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0eafe8e66aabd5f8ec42aa47128ba7e563225376 --- /dev/null +++ b/080/surgery_report.txt @@ -0,0 +1 @@ +Once again, after intubation by the anesthesia colleagues, pharyngoscopy and laryngoscopy as well as MLE. The distended tumor can be seen, which is located on both vocal folds, reaches just in front of the arytenoid region and extends to the anterior commissure in each case. Overall, with clearly deep tumor growth, laser resection does not make sense, but rather an external approach. Therefore now repositioning. Skin disinfection. Injection of a total of 10 ml with Ultracaine 1% with adrenaline. Sterile draping. Z-incision with the possibility of creating a tracheostomy underneath. Subsequent dissection of the subcutaneous tissue. Separation of the infrahyoid muscles. Exposure of the larynx. Creation of a perichondrium flap, which extends from right to left and is pedicled there. Subsequent insertion into the larynx after sawing out a triangle, which protrudes anteriorly and to the right. Then push off the mucosa and the perichondrium on both sides directly from the cartilage to behind the arytenoid region. After enoral inspection, now subglottic entry, from there development of the tumor also subglottically at the upper edge of the cricoid cartilage. Then develop the tumor supraglottically on both sides, whereby the pocket fold must also be resected on both sides. Posterior resection of the anterior lower parts of the arytenoid cartilage on both sides, but the main part at the back remains intact. The tumor is removed in its entirety and also marked with sutures. Due to the extent of the tumor, marginal samples are taken. Left supraglottic margin specimens with anterior suture marking, left subglottic anterior/subglottic left suture marking anterior basal left with paraglottic musculature, subglottic right anterior suture, right arytenoid region, supraglottic right, paraglottic basal right with musculature and supraglottic right with anterior suture marking. All frozen section margin samples without evidence of tumor, thus R0 resection. Careful hemostasis is now performed. Now, due to the extent of the tumor and the expected temporary dysphagia, a tracheostoma is created: This is done through a small Kocher incision, which is made caudally. Visualization of the trachea. Insertion between the second and third tracheal cartilage. Creation of a modified Björk flap. This is epithelized in the typical manner, without tension. Subsequently reintubation and insertion of an 8 mm tracheal cannula. Then closure of the larynx. Drill holes are made and the thyroid cartilage is sutured together using 3.0 Vicryl single-button sutures. Subsequent suturing of the perichondrial flap with the perichondrium lying inwards on the right side, ensuring tension-free, complete and secure closure. Then suture the infrahyoid muscles. Flap insertion and layered wound closure. Application of Steristrip dressing. Completion of the procedure without complications. Overall extensive cT2 laryngeal carcinoma with infiltration of the glottis up to just before the arytenoid region as well as parts of the supraglottic region, mainly on the left, less so on the right. The arytenoid region is essentially preserved, dysphagia to be expected temporarily. Therefore temporary placement of a nasogastric tube. The final postoperative histology is awaited and then discussed in the interdisciplinary tumor conference. Plan closure of tracheostoma at intervals. \ No newline at end of file diff --git a/081/InvasionFront_CD3_block7_x1_y6_patient081_0.json b/081/InvasionFront_CD3_block7_x1_y6_patient081_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b8bef4c13aa2dc833e87361711b35addf6045c71 --- /dev/null +++ b/081/InvasionFront_CD3_block7_x1_y6_patient081_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4047.9, + "Centroid Y µm": 14592.3, + "Num Detections": 15610, + "Num Negative": 15044, + "Num Positive": 566, + "Positive %": 3.626, + "Num Positive per mm^2": 312.21 + } +} \ No newline at end of file diff --git a/081/InvasionFront_CD3_block7_x2_y6_patient081_1.json b/081/InvasionFront_CD3_block7_x2_y6_patient081_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9b45681d39c525c40e2af0c30fbcf83d6ca009c --- /dev/null +++ b/081/InvasionFront_CD3_block7_x2_y6_patient081_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6733.9, + "Centroid Y µm": 14579.8, + "Num Detections": 21519, + "Num Negative": 20732, + "Num Positive": 787, + "Positive %": 3.657, + "Num Positive per mm^2": 317.13 + } +} \ No newline at end of file diff --git a/081/InvasionFront_CD8_block7_x1_y6_patient081_0.json b/081/InvasionFront_CD8_block7_x1_y6_patient081_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2c5ceb076064ad52c6880e104b84f638ba642e84 --- /dev/null +++ b/081/InvasionFront_CD8_block7_x1_y6_patient081_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5059.8, + "Centroid Y µm": 14542.3, + "Num Detections": 14429, + "Num Negative": 13471, + "Num Positive": 958, + "Positive %": 6.639, + "Num Positive per mm^2": 568.24 + } +} \ No newline at end of file diff --git a/081/InvasionFront_CD8_block7_x2_y6_patient081_1.json b/081/InvasionFront_CD8_block7_x2_y6_patient081_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2c51e311f834d6b61c10003e9eb12e6aa4858f3c --- /dev/null +++ b/081/InvasionFront_CD8_block7_x2_y6_patient081_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7808.4, + "Centroid Y µm": 14804.7, + "Num Detections": 21287, + "Num Negative": 19925, + "Num Positive": 1362, + "Positive %": 6.398, + "Num Positive per mm^2": 564.9 + } +} \ No newline at end of file diff --git a/081/TumorCenter_CD3_block7_x1_y6_patient081_0.json b/081/TumorCenter_CD3_block7_x1_y6_patient081_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eecede64ba0312b204d35fdc4cdfe51cac3ebe0e --- /dev/null +++ b/081/TumorCenter_CD3_block7_x1_y6_patient081_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 14892.1, + "Num Detections": 15189, + "Num Negative": 13190, + "Num Positive": 1999, + "Positive %": 13.16, + "Num Positive per mm^2": 1028.2 + } +} \ No newline at end of file diff --git a/081/TumorCenter_CD3_block7_x2_y6_patient081_1.json b/081/TumorCenter_CD3_block7_x2_y6_patient081_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7a38970c5590fe07a80d4ecfd31718715a2229be --- /dev/null +++ b/081/TumorCenter_CD3_block7_x2_y6_patient081_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 15042.0, + "Num Detections": 19372, + "Num Negative": 14543, + "Num Positive": 4829, + "Positive %": 24.93, + "Num Positive per mm^2": 2051.7 + } +} \ No newline at end of file diff --git a/081/TumorCenter_CD8_block7_x1_y6_patient081_0.json b/081/TumorCenter_CD8_block7_x1_y6_patient081_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fbb8c56384ce568104a4826711a0c10ec550fc88 --- /dev/null +++ b/081/TumorCenter_CD8_block7_x1_y6_patient081_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3398.2, + "Centroid Y µm": 14967.1, + "Num Detections": 19891, + "Num Negative": 18002, + "Num Positive": 1889, + "Positive %": 9.497, + "Num Positive per mm^2": 830.1 + } +} \ No newline at end of file diff --git a/081/TumorCenter_CD8_block7_x2_y6_patient081_1.json b/081/TumorCenter_CD8_block7_x2_y6_patient081_1.json new file mode 100644 index 0000000000000000000000000000000000000000..275972eb3a62f15a98168e3ec35dc59e1142cb82 --- /dev/null +++ b/081/TumorCenter_CD8_block7_x2_y6_patient081_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5971.8, + "Centroid Y µm": 15092.0, + "Num Detections": 21362, + "Num Negative": 17665, + "Num Positive": 3697, + "Positive %": 17.31, + "Num Positive per mm^2": 1571.9 + } +} \ No newline at end of file diff --git a/081/history_text.txt b/081/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d2f84ff9e8737b395e2ad1023a415a1d486775c --- /dev/null +++ b/081/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT1 hypopharyngeal carcinoma on the right was histologically confirmed during a panendoscopy <2014>, with initial signs of CUP syndrome with right cervical lymph node metastasis. In our interdisciplinary tumor conference, the primary surgical procedure was recommended. CT diagnostics showed the primary tumor to be poorly defined in the area of the right piriform sinus. There was also an unclear change in the right tonsil. The most recent ultrasound showed a cN1 neck status on the right. \ No newline at end of file diff --git a/081/icd_codes.txt b/081/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8e643502764d908a1f2aa00badd68302533879c7 --- /dev/null +++ b/081/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] \ No newline at end of file diff --git a/081/ops_codes.txt b/081/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5472f1e8167d6c15a4b8963967a7e1dd48d7c5ae --- /dev/null +++ b/081/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] ohne Rekonstruktion[5-296.00 ] Laserkoagulation Pharynxgewebe[5-292.31 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 B] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/081/patient_clinical_data.json b/081/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9edafca2e6489b4708996b59083c1c31f6941fc9 --- /dev/null +++ b/081/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 32, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/081/patient_pathological_data.json b/081/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6ec1c823272c56bb7bfd65556c6dad8430359693 --- /dev/null +++ b/081/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "081", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/081/surgery_description.txt b/081/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4826340a2311ae89910c511dafe5d9cf17209bd0 --- /dev/null +++ b/081/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Neck dissection, and Tracheotomy diff --git a/081/surgery_report.txt b/081/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6b23fb1badf09f35182579c405e0881ae25e6263 --- /dev/null +++ b/081/surgery_report.txt @@ -0,0 +1 @@ +After positioning the patient, first enter with the small irrigation tube while protecting the dental ridge. Inconspicuous oral cavity. Careful inspection of the oropharynx, especially the tonsil regions. Careful palpation and inspection. There are absolutely symmetrical, slightly bumpy and cryptic tonsils on both sides, absolutely idem in lateral comparison. Therefore, no further measures are taken here. Adjustment of the endolarynx. This is inconspicuous and free. The same applies to the left hypopharynx. In the area of the right piriform sinus, starting in the entrance area, an exophytic, coarse mass is now visible, relatively well demarcated. This extends from the piriform sinus over the posterior and lateral wall to just before the tip and can be easily moved by palpation, but has an infiltration depth or tumor thickness of just under 1 cm. Due to the good displaceability and visualization, the decision was made to perform a primary laser resection. Resection of the tumor with the CO2 laser 2.0 W, microscopically controlled. Complete removal. Good controllability in the depth range. Slightly more difficult resection conditions in the direction of the tip of the piriform sinus. Otherwise complete in-sano removal with particularly good control in the direction of deep growth. The entire tumor in the area of the mucosa is now covered with marginal samples. In addition, samples are taken from the basal tissue and the muscles located here. All samples are diagnosed as tumor- and dysplasia-free. An R0 situation can therefore be assumed here. Careful hemostasis. Due to the resection area with contact to the lateral hypopharyngeal side wall, a tracheostomy is later indicated. Performing flexible esophagogastroscopy for the planned PEG insertion: Easy pre-scanning into the stomach. Despite optimized positioning, there is no diaphanoscopy. Therefore, a PEG insertion must be dispensed with at this point. A nasogastric feeding tube is inserted under laryngoscopic control. Repositioning for neck dissection. Injection of xylocaine with added adrenaline. Start on the right side. Clearly palpable, coarse mass of a good 3 cm in size at level II. Dissection of skin and subcutaneous tissue. Exposure of the sternocleidomastoid muscle. Exposure and preservation of the auricularis magnus nerve. The external jugular vein is removed. Exposure of the omohyoid muscle, exposure of the submandibular gland and the digastric muscle. Removal of the anterior neck preparation, carefully preserving the facial vein, the cervical vein, the hypoglossal nerve and the superior thyroid artery. Free preparation of the internal jugular vein. The highly suspicious mass described above can be seen in the area of the jugulofacial angle. After careful dissection, the metastasis can be detached from the internal jugular vein, the accessorius nerve and the sternocleidomastoid muscle. Release of the accessorius triangle and clearing of level V with careful protection of the cervical plexus branches. A clearly suspicious mass is also visible in level III, lateral to the internal jugular vein. Dissection up to the transition to level V b. Final wound inspection. In dry wound conditions, after wound irrigation, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Repositioning to the opposite side. In principle exactly the same procedure here. After exposing the surrounding musculature, evacuation of the anterior neck preparation with careful protection of the cervical artery, the superior thyroid artery, the hypoglossal nerve and the facial vein. Here, too, a mass measuring a good 2.5 cm was found in the area of the jugulofacial angle. Macroscopically clearly suspicious. Therefore, complete evacuation of the accessorius triangle with careful protection of the nerve. Clearing of level V a with careful protection of the cervical plexus branches, protection and exposure of the common carotid artery and vagus nerve. Final inspection. Careful hemostasis. Wound irrigation, insertion of a 10-gauge Redon drainage, two-layer wound closure. Finally, a protective tracheotomy is performed: for this purpose, a skin incision is made approx. 1 cm below the cricoid cartilage. Cut through the skin and subcutaneous tissue. Expose and cut through the infrahyoid muscles. Exposure of the cricoid cartilage, exposure of the anterior surface of the trachea. Creation of a broad-based pedicled Björ flap and subsequent insertion of the tracheostoma in the usual manner. Easy transfer to a size 8 low-cuff cannula. Final enoral inspection of the resection area. The procedure was completed with dry wound conditions and no indication of complications. Conclusion: Intraoperative R0-resected cT2 hypopharyngeal carcinoma on the right. Intraoperative high-grade cN2c neck status. Please feed via the inserted nasogastric feeding tube for about 4-5 days. After that, gradual diet build-up possible. Due to the adjuvant therapy that will certainly be required, a second PEG should be inserted. However, this should not be done before the 10th postoperative day. If swallowing function and enoral healing are normal, decannulation should be possible during the inpatient course. \ No newline at end of file diff --git a/082/InvasionFront_CD3_block18_x3_y1_patient082_0.json b/082/InvasionFront_CD3_block18_x3_y1_patient082_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b79cf31ec62d36ecafad3f7159d7afb0563ae28 --- /dev/null +++ b/082/InvasionFront_CD3_block18_x3_y1_patient082_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12218.5, + "Centroid Y µm": 7121.2, + "Num Detections": 16598, + "Num Negative": 16538, + "Num Positive": 60, + "Positive %": 0.3615, + "Num Positive per mm^2": 29.21 + } +} \ No newline at end of file diff --git a/082/InvasionFront_CD3_block18_x4_y1_patient082_1.json b/082/InvasionFront_CD3_block18_x4_y1_patient082_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f2dc08f680615978bc4ab32b76b1f14f51fe2540 --- /dev/null +++ b/082/InvasionFront_CD3_block18_x4_y1_patient082_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14667.2, + "Centroid Y µm": 7121.2, + "Num Detections": 10286, + "Num Negative": 9911, + "Num Positive": 375, + "Positive %": 3.646, + "Num Positive per mm^2": 316.3 + } +} \ No newline at end of file diff --git a/082/InvasionFront_CD8_block18_x3_y1_patient082_0.json b/082/InvasionFront_CD8_block18_x3_y1_patient082_0.json new file mode 100644 index 0000000000000000000000000000000000000000..274130145675bcafe2db424071db84f1f7b7a1d0 --- /dev/null +++ b/082/InvasionFront_CD8_block18_x3_y1_patient082_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11294.0, + "Centroid Y µm": 10644.4, + "Num Detections": 13214, + "Num Negative": 13196, + "Num Positive": 18, + "Positive %": 0.1362, + "Num Positive per mm^2": 11.25 + } +} \ No newline at end of file diff --git a/082/InvasionFront_CD8_block18_x4_y1_patient082_1.json b/082/InvasionFront_CD8_block18_x4_y1_patient082_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cbaf2f5761a218fd6de008d14e6d1d78f16b6a6e --- /dev/null +++ b/082/InvasionFront_CD8_block18_x4_y1_patient082_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13967.6, + "Centroid Y µm": 10644.4, + "Num Detections": 9171, + "Num Negative": 8642, + "Num Positive": 529, + "Positive %": 5.768, + "Num Positive per mm^2": 472.11 + } +} \ No newline at end of file diff --git a/082/TumorCenter_CD3_block18_x3_y1_patient082_0.json b/082/TumorCenter_CD3_block18_x3_y1_patient082_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9df3e9b9e4eb53a55b64b06e257faa5499924c24 --- /dev/null +++ b/082/TumorCenter_CD3_block18_x3_y1_patient082_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11114.9, + "Centroid Y µm": 2523.5, + "Num Detections": 13737, + "Num Negative": 13689, + "Num Positive": 48, + "Positive %": 0.3494, + "Num Positive per mm^2": 21.12 + } +} \ No newline at end of file diff --git a/082/TumorCenter_CD3_block18_x4_y1_patient082_1.json b/082/TumorCenter_CD3_block18_x4_y1_patient082_1.json new file mode 100644 index 0000000000000000000000000000000000000000..89f3804fcfb9b9a319876a37555813a960590ba1 --- /dev/null +++ b/082/TumorCenter_CD3_block18_x4_y1_patient082_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13565.7, + "Centroid Y µm": 2598.5, + "Num Detections": 16801, + "Num Negative": 16770, + "Num Positive": 31, + "Positive %": 0.1845, + "Num Positive per mm^2": 13.12 + } +} \ No newline at end of file diff --git a/082/TumorCenter_CD8_block18_x3_y1_patient082_0.json b/082/TumorCenter_CD8_block18_x3_y1_patient082_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac53993e17555759bb565f0e94b57608014a5778 --- /dev/null +++ b/082/TumorCenter_CD8_block18_x3_y1_patient082_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11094.1, + "Centroid Y µm": 3048.4, + "Num Detections": 21698, + "Num Negative": 20852, + "Num Positive": 846, + "Positive %": 3.899, + "Num Positive per mm^2": 348.18 + } +} \ No newline at end of file diff --git a/082/TumorCenter_CD8_block18_x4_y1_patient082_1.json b/082/TumorCenter_CD8_block18_x4_y1_patient082_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8a3e51da36ce00c3bfdfb22c32d5ec562374d0df --- /dev/null +++ b/082/TumorCenter_CD8_block18_x4_y1_patient082_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 3123.3, + "Num Detections": 23875, + "Num Negative": 23504, + "Num Positive": 371, + "Positive %": 1.554, + "Num Positive per mm^2": 148.4 + } +} \ No newline at end of file diff --git a/082/history_text.txt b/082/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0533c30fc09a30db79ca44bd1ea8732f34138211 --- /dev/null +++ b/082/history_text.txt @@ -0,0 +1 @@ +In the patient, a squamous cell carcinoma in the middle third of the left vocal fold was histologically confirmed. Now indication for laser resection. \ No newline at end of file diff --git a/082/icd_codes.txt b/082/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15cdf3cedbb267117d620058bfef3b6f5d6fd43f --- /dev/null +++ b/082/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/082/ops_codes.txt b/082/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..349cf7c7607ff28a247e8ea84b89b33f4b830233 --- /dev/null +++ b/082/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] \ No newline at end of file diff --git a/082/patient_clinical_data.json b/082/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..23037e1dff3b1793202858f4ac7990b286bda4b8 --- /dev/null +++ b/082/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 46, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/082/patient_pathological_data.json b/082/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9421713cf86013ba392dc15da9b81a371bba7a60 --- /dev/null +++ b/082/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "082", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/082/surgery_description.txt b/082/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a777490453c99d3d5c1e0701782ff2ac3fefa7d6 --- /dev/null +++ b/082/surgery_description.txt @@ -0,0 +1 @@ +MLE (Microlaryngoscopy and Endoscopy), Laser resection diff --git a/082/surgery_report.txt b/082/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a9015bd0cf327d25e303afe7c2e5e8dd18ac9570 --- /dev/null +++ b/082/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, the surgeon positions the patient. Insertion of the B-tube and adjustment of the glottic plane, which is successful. Use of the operating microscope. A submucosally growing, nodular mass is seen directly in the middle of the left vocal fold, which extends slightly in the direction of the morgue sinus. The arytenoid cartilage and the anterior commissure are free. Macroscopically, there is no expansion into the subglottic slope or infiltration of the supraglottis. Now set the CO2 laser to 4 watts and laser out the mass, partially taking along the thyroarytaenoid muscle up to the anterior edge of the vocal process, which is exposed in the anterior region. Separation of the mass to the subglottic slope and removal of the resectate, which is sent for final histology. Now take marginal samples from the wound bed, the morgue sinus in strips, the subglottic slope in strips and anterior posteriorly in the area of the vocal fold level. The frozen section also reveals a carcinoma on the subglottic slope, which is resected with the CO2 laser, taking a resection several mm subglottically and leaving the conus elasticus intact. A new strip-shaped marginal sample is then taken from the subglottic slope, which is indicated as tumor-free in the histological frozen section. Meticulous hemostasis with anticoagulation with ASA and clopidogrel using monopolar coagulation. If the wound is completely dry, the procedure is completed without complications. \ No newline at end of file diff --git a/083/InvasionFront_CD3_block2_x5_y5_patient083_0.json b/083/InvasionFront_CD3_block2_x5_y5_patient083_0.json new file mode 100644 index 0000000000000000000000000000000000000000..81074e1e7eed24439f4492a249076b54b5c9daa6 --- /dev/null +++ b/083/InvasionFront_CD3_block2_x5_y5_patient083_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 26061.2, + "Num Detections": 24735, + "Num Negative": 22091, + "Num Positive": 2644, + "Positive %": 10.69, + "Num Positive per mm^2": 1159.2 + } +} \ No newline at end of file diff --git a/083/InvasionFront_CD3_block2_x6_y5_patient083_1.json b/083/InvasionFront_CD3_block2_x6_y5_patient083_1.json new file mode 100644 index 0000000000000000000000000000000000000000..68e8e105090c6a9989b8dbe8012f013809f99954 --- /dev/null +++ b/083/InvasionFront_CD3_block2_x6_y5_patient083_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21441.7, + "Centroid Y µm": 26115.4, + "Num Detections": 27822, + "Num Negative": 21192, + "Num Positive": 6630, + "Positive %": 23.83, + "Num Positive per mm^2": 2450.7 + } +} \ No newline at end of file diff --git a/083/InvasionFront_CD8_block2_x5_y5_patient083_0.json b/083/InvasionFront_CD8_block2_x5_y5_patient083_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0f52779ce4010b5e7b12e115033da6eed4275d2b --- /dev/null +++ b/083/InvasionFront_CD8_block2_x5_y5_patient083_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17640.7, + "Centroid Y µm": 13717.7, + "Num Detections": 22874, + "Num Negative": 18885, + "Num Positive": 3989, + "Positive %": 17.44, + "Num Positive per mm^2": 1855.7 + } +} \ No newline at end of file diff --git a/083/InvasionFront_CD8_block2_x6_y5_patient083_1.json b/083/InvasionFront_CD8_block2_x6_y5_patient083_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc10ece9b8d48e10423a56af20b739119b0f3f9a --- /dev/null +++ b/083/InvasionFront_CD8_block2_x6_y5_patient083_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20264.3, + "Centroid Y µm": 13767.7, + "Num Detections": 28010, + "Num Negative": 19336, + "Num Positive": 8674, + "Positive %": 30.97, + "Num Positive per mm^2": 3209.2 + } +} \ No newline at end of file diff --git a/083/TumorCenter_CD3_block2_x5_y5_patient083_0.json b/083/TumorCenter_CD3_block2_x5_y5_patient083_0.json new file mode 100644 index 0000000000000000000000000000000000000000..321f33a4eb6f273ea42a4a94469e2f7babef53dc --- /dev/null +++ b/083/TumorCenter_CD3_block2_x5_y5_patient083_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 12368.5, + "Num Detections": 26479, + "Num Negative": 15758, + "Num Positive": 10721, + "Positive %": 40.49, + "Num Positive per mm^2": 3825.8 + } +} \ No newline at end of file diff --git a/083/TumorCenter_CD3_block2_x6_y5_patient083_1.json b/083/TumorCenter_CD3_block2_x6_y5_patient083_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5076b235c10d623b420f03a40e264684287117e7 --- /dev/null +++ b/083/TumorCenter_CD3_block2_x6_y5_patient083_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 12418.4, + "Num Detections": 31886, + "Num Negative": 25758, + "Num Positive": 6128, + "Positive %": 19.22, + "Num Positive per mm^2": 2153.5 + } +} \ No newline at end of file diff --git a/083/TumorCenter_CD8_block2_x5_y5_patient083_0.json b/083/TumorCenter_CD8_block2_x5_y5_patient083_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e4e42229b6fb68e0f6d30382e7b02a26971f8267 --- /dev/null +++ b/083/TumorCenter_CD8_block2_x5_y5_patient083_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18090.4, + "Centroid Y µm": 12018.6, + "Num Detections": 27888, + "Num Negative": 17850, + "Num Positive": 10038, + "Positive %": 35.99, + "Num Positive per mm^2": 3568.0 + } +} \ No newline at end of file diff --git a/083/TumorCenter_CD8_block2_x6_y5_patient083_1.json b/083/TumorCenter_CD8_block2_x6_y5_patient083_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e0827e3b8728252793af52a87a5609ae95df860 --- /dev/null +++ b/083/TumorCenter_CD8_block2_x6_y5_patient083_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20764.0, + "Centroid Y µm": 11943.7, + "Num Detections": 32488, + "Num Negative": 29364, + "Num Positive": 3124, + "Positive %": 9.616, + "Num Positive per mm^2": 1099.9 + } +} \ No newline at end of file diff --git a/083/history_text.txt b/083/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..dd7864cc1de3f2253c9b0e6acf67f5e7227197d8 --- /dev/null +++ b/083/history_text.txt @@ -0,0 +1 @@ +The patient had a panendoscopy with a sample biopsy of the right lymph node, right glossotonsillar groove and stomach. There was no evidence of a suspicious mass. Subsequent gross needle PE of the right cervical lymph node. In this case squamous cell carcinoma. The diagnosis of CUP cN2b on the right was then made. The PET-CT shows an enhancement in the area of the oropharynx/tonsil lobe on the right. In addition, the right cervical lymph node metastasis was found to be growing almost to the primary in question per continuitatem. Based on the medical history and clinical findings, indication for the above-mentioned procedure. \ No newline at end of file diff --git a/083/icd_codes.txt b/083/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e6aed487201f57db651d4c3d5370d1e8411f4a75 --- /dev/null +++ b/083/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Gaumenbogentonsillen[C09.1 R] \ No newline at end of file diff --git a/083/ops_codes.txt b/083/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15735130a0d32680764243ff3c2599dffb1027ff --- /dev/null +++ b/083/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie: Bei normalem Situs[1-631.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/083/patient_clinical_data.json b/083/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..271b12a88b59a6bcfe62244d4f59a0afb02ef951 --- /dev/null +++ b/083/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 84, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/083/patient_pathological_data.json b/083/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..48d2c22c2a20f4a817564ead16ef3b2da82250f0 --- /dev/null +++ b/083/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "083", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN3", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 14, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/083/surgery_description.txt b/083/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e98cc65c022ec00868f70bedf68bbc13e6f7a373 --- /dev/null +++ b/083/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Panendoscopy diff --git a/083/surgery_report.txt b/083/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..02ddf5bf7fae3bdca1a56b38134863ee63edeb47 --- /dev/null +++ b/083/surgery_report.txt @@ -0,0 +1 @@ +First, the patient is taken to the operating room, then the team time-out is carried out and active patient identification and consultation with anesthesia colleagues are performed. Induction of anesthesia and tracheobronchoscopy with the aid of the laryngeal blade and 0° optics. Entering the glottis and pre-mirroring up to the carina. Unobtrusive mucosal conditions on all sides of the carina, trachea, vocal folds, subglottic and glottic area. Then intubation by the surgeon. The surgeon then positions the head and inspects and palpates the oral cavity and oropharynx. The right tonsil is more palpable than the left tonsil. The base of the tongue is palpably unremarkable and soft, as are the tongue and the floor of the mouth. Now re-inspect the oropharynx, larynx and hypopharynx with the type C small bore tube. This reveals the tonsil with a small ulcer, possibly suspicious. Otherwise, the base of the tongue, the vallecula, the epiglottis, the piriform sinuses on both sides, the aryepiglottic folds, the arytenoid cartilage, the glottic plane, the vocal folds and the epiglottis, posterior pharyngeal wall and posterior and lateral walls of the hypopharynx are unremarkable. On the right paramedian posterior wall of the oropharynx, the ACI is visible both by inspection and palpation; it does not reach the tonsil lobe. Now insert the McIvor oral spatula while protecting the lips, teeth and tongue. Demonstration of findings to . In the case of primary tonsillitis in the tonsil larynx, tonsillectomy, which goes to the frozen section. The tonsil is grasped at the upper pole and a parauvular mucosal incision is made, which is extended cranially as well as ventrally and dorsally caudally. The tonsil is dissected out along its capsule using a rasparator and deposited very far caudally at the base of the tongue after bipolar coagulation. The tonsil is marked with a suture in the area of the wound base, where the tumor is most likely to be palpated, and caudally at 6 o'clock. The tonsil lobe is free of tumor on inspection and palpation. The tonsil goes to the frozen section. Here, the wound base is marginally R0 less than 0.1 cm, and also marginally R0 ventrally at 9 o'clock in the direction of the anterior palatal arch, but with margin-forming CIS. The remaining caudal, dorsal and cranial margins are free. After consultation with , resection in the sense of a margin sample in the wound bed, this is thread-marked for final histology, marked cranially in the wound bed of the wound bed and marked ventrally towards the anterior palatal arch. In addition, resection of the anterior palatal arch marked cranially with a suture and then another marginal sample of the anterior palatal arch consisting of 2 parts, each marked cranially with a suture. Now detailed hemostasis by means of bipolar coagulation. Macroscopically no more evidence of tumor. The ACI is not in the area of the resection bed, but close enough. No opening towards the neck. Insertion of hydrogen swabs. Repeated inspection using a small mirror. No further bleeding. Unblocking, head elevation. No further bleeding. Now insertion of a PEG in the typical manner using the pull-through technique after a clear diaphanoscopy and after disinfection of the upper abdomen. This was successful without any problems. The procedure was completed without complications and the surgeon repositioned the head. Conclusion: V.a. cT1 cN2b tonsillar carcinoma, in the frozen section margin-forming CIS on the anterior palatal arch and squamous cell carcinoma marginal R0. Subsequently, further marginal samples were taken at the base of the wound and on the anterior palatal arch. Awaiting the final histology. Two-stage neck dissection. To be on the safe side, clarification for flap coverage in case an oropharyngeal fistula could develop as a result of the neck dissection. \ No newline at end of file diff --git a/084/InvasionFront_CD3_block20_x5_y12_patient084_0.json b/084/InvasionFront_CD3_block20_x5_y12_patient084_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7686edba369cd2916190b38a0963ebfef0e438dc --- /dev/null +++ b/084/InvasionFront_CD3_block20_x5_y12_patient084_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 29684.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/084/InvasionFront_CD3_block20_x6_y12_patient084_1.json b/084/InvasionFront_CD3_block20_x6_y12_patient084_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a15bb470d47770898603c3d029d05258b4203e0 --- /dev/null +++ b/084/InvasionFront_CD3_block20_x6_y12_patient084_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 29909.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/084/InvasionFront_CD8_block20_x5_y11_patient084_0.json b/084/InvasionFront_CD8_block20_x5_y11_patient084_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad975403a0adf6749b79a1ee52f7fa59f1d39a2c --- /dev/null +++ b/084/InvasionFront_CD8_block20_x5_y11_patient084_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17340.8, + "Centroid Y µm": 27360.5, + "Num Detections": 24373, + "Num Negative": 23567, + "Num Positive": 806, + "Positive %": 3.307, + "Num Positive per mm^2": 290.16 + } +} \ No newline at end of file diff --git a/084/InvasionFront_CD8_block20_x6_y11_patient084_1.json b/084/InvasionFront_CD8_block20_x6_y11_patient084_1.json new file mode 100644 index 0000000000000000000000000000000000000000..092bcff7559f2cf95144a8a8dd1c7c5d2bb6bd2f --- /dev/null +++ b/084/InvasionFront_CD8_block20_x6_y11_patient084_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19889.5, + "Centroid Y µm": 27285.6, + "Num Detections": 21662, + "Num Negative": 21132, + "Num Positive": 530, + "Positive %": 2.447, + "Num Positive per mm^2": 205.58 + } +} \ No newline at end of file diff --git a/084/TumorCenter_CD3_block20_x5_y11_patient084_0.json b/084/TumorCenter_CD3_block20_x5_y11_patient084_0.json new file mode 100644 index 0000000000000000000000000000000000000000..462b1ec7431507dd0e857bd8fac27def052baf8f --- /dev/null +++ b/084/TumorCenter_CD3_block20_x5_y11_patient084_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15985.7, + "Centroid Y µm": 26570.0, + "Num Detections": 21710, + "Num Negative": 20576, + "Num Positive": 1134, + "Positive %": 5.223, + "Num Positive per mm^2": 420.49 + } +} \ No newline at end of file diff --git a/084/TumorCenter_CD3_block20_x6_y11_patient084_1.json b/084/TumorCenter_CD3_block20_x6_y11_patient084_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e346792bae2c9ec3219f4d3630502df125f1770d --- /dev/null +++ b/084/TumorCenter_CD3_block20_x6_y11_patient084_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18597.7, + "Centroid Y µm": 26540.0, + "Num Detections": 15644, + "Num Negative": 15222, + "Num Positive": 422, + "Positive %": 2.698, + "Num Positive per mm^2": 213.12 + } +} \ No newline at end of file diff --git a/084/TumorCenter_CD8_block20_x5_y11_patient084_0.json b/084/TumorCenter_CD8_block20_x5_y11_patient084_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6bb6362f5ac191970f9cc661126980458a68a34e --- /dev/null +++ b/084/TumorCenter_CD8_block20_x5_y11_patient084_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 27385.5, + "Num Detections": 19270, + "Num Negative": 19096, + "Num Positive": 174, + "Positive %": 0.903, + "Num Positive per mm^2": 72.54 + } +} \ No newline at end of file diff --git a/084/TumorCenter_CD8_block20_x6_y11_patient084_1.json b/084/TumorCenter_CD8_block20_x6_y11_patient084_1.json new file mode 100644 index 0000000000000000000000000000000000000000..561bb4acd2c4e319fbccbdb9b108f4bd0328d5d6 --- /dev/null +++ b/084/TumorCenter_CD8_block20_x6_y11_patient084_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18404.9, + "Centroid Y µm": 27893.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/084/history_text.txt b/084/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..14eea1910c511d237ed09096ad899223f81a7ddf --- /dev/null +++ b/084/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: In the case of histologically confirmed squamous cell carcinoma of the right larynx (external histology), indication for surgical procedure after the patient has been informed accordingly. \ No newline at end of file diff --git a/084/icd_codes.txt b/084/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/084/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/084/ops_codes.txt b/084/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cbc8e715b70b487dfed69807c5ee5b11d96a46b4 --- /dev/null +++ b/084/ops_codes.txt @@ -0,0 +1 @@ +Larynxteilresektion frontal[5-302.6 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/084/patient_clinical_data.json b/084/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..89b3c7a02d39c39fa1ab3c82705ac535c39b4f2b --- /dev/null +++ b/084/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/084/patient_pathological_data.json b/084/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..77ba4cffe4f30ed8340e8a01f27a7070b26b0966 --- /dev/null +++ b/084/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "084", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/084/surgery_description.txt b/084/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f42edc6682aaec53ddfe148a157c84f74e364ac9 --- /dev/null +++ b/084/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection, MLE, Panendoscopy diff --git a/084/surgery_report.txt b/084/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..092b3133295255f60828bc48c9f981ed0b657fc2 --- /dev/null +++ b/084/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Then advance the 0° telescope through the glottic plane into the trachea. Inconspicuous mucosal conditions in the area of the trachea. Further advancement of the endoscope to the exit of the segmental bronchi on both sides. Inconspicuous mucosal conditions on all sides. Now intubate the patient. Then advance the flexible esophagoscope into the stomach. Careful reflection back. Inconspicuous findings in the area of the esophagus. Now inspect the hypopharynx on both sides and the postcricoid region: Inconspicuous mucosal conditions. Inspection of the oropharynx and the oral cavity: normal mucosal conditions on all sides. Adjustment of the larynx with the small small bore tube (size C). Exposure of the glottic plane is very difficult with this tube. A large tumor is seen, which starts from the right vocal fold and extends to the transition from the middle to the posterior third of the vocal fold. The tumor extends to the anterior commissure. It is not possible to differentiate the tumor from the left side by microlaryngoendoscopy. Try to adjust the glottic plane with the smallest tube. Here too, a safe resection is not possible with a known malignant tumor. Therefore, indication for an external procedure. Application of local anesthesia in the prelaryngeal soft tissue area. Abjode and cover the surgical area. Zigzag incision in the median line. Dissection through the fatty tissue. Exposure of the infrahyoid musculature. Exposure of the linea alba. Exposure of the thyroid cartilage. Exposure of the cricoid cartilage, exposure of the ligamentum conicum. Opening of the larynx in the median line after the ligamentum conicum has been split. Careful opening of the larynx by dissecting the supraglottis and subglottis. A voluminous tumor is seen, which fills the vocal fold on the right and starts from the transition from the posterior to the middle third of the vocal fold, freely invades the morgue sinus..........................., the subglottic slope and extends to just before the anterior commissure. Clinically, no tumor is detectable on the left side. However, there is a circumscribed leukoplakia on the left side in the area of the anterior third of the vocal fold, which is left in place during further dissection. This should be removed during a control microlaryngoendoscopy 6-8 weeks postoperatively. Now return to the tumor. This tumor extends forward to the ligamentum conicum. Careful resection of the tumor and clinical removal of the tumor in healthy tissue. The vocal process of the arytenoid cartilage is freed of mucosa. The resection covers the areas of tumor extension described above, whereby the tumor has not infiltrated deep into the vocalis muscle so that parts of the vocalis muscle can be preserved. Careful hemostasis. Removal of six marginal samples. Careful hemostasis. As part of the frozen section diagnosis, a carcinoma in situ is diagnosed in the area of the posterior margin sample below the arytenoid cartilage. As a result, resection is performed. The new frozen section histology shows a tumor-free resection. After careful hemostasis, two drill holes were made in the area of the thyroid cartilage. Closure of the thyroid cartilage with two Vicryl sutures. Reconstruction of the ligamentum conicum. Irrigation of the wound with water and hydrogen. Readaptation of the infrahyoid musculature after insertion of a flap. Wound closure in layers. Wound dressing. Final consultation with the anesthetist. The patient is transferred to the intensive care unit extubated and should be observed there for two days postoperatively. The patient therefore has a T1a laryngeal carcinoma, which was resected in healthy tissue using frozen section histology. Due to the extent of the tumor, a control microlaryngoendoscopy is absolutely necessary in 6-8 weeks. Attention should also be paid to the anterior third of the vocal fold on the left. As the resection did not include the anterior commissure of the left side, the insertion of a Keel is dispensed with. \ No newline at end of file diff --git a/085/InvasionFront_CD3_block1_x5_y11_patient085_0.json b/085/InvasionFront_CD3_block1_x5_y11_patient085_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f423ede8730d4fdd6eed97fb83870df628a7eb73 --- /dev/null +++ b/085/InvasionFront_CD3_block1_x5_y11_patient085_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 29559.3, + "Num Detections": 10890, + "Num Negative": 10761, + "Num Positive": 129, + "Positive %": 1.185, + "Num Positive per mm^2": 96.9 + } +} \ No newline at end of file diff --git a/085/InvasionFront_CD3_block1_x6_y11_patient085_1.json b/085/InvasionFront_CD3_block1_x6_y11_patient085_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2ef495ab61df8947d76f1fc34a9cc1d6835ea952 --- /dev/null +++ b/085/InvasionFront_CD3_block1_x6_y11_patient085_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 29659.3, + "Num Detections": 11845, + "Num Negative": 11841, + "Num Positive": 4, + "Positive %": 0.0338, + "Num Positive per mm^2": 3.084 + } +} \ No newline at end of file diff --git a/085/InvasionFront_CD8_block1_x5_y11_patient085_0.json b/085/InvasionFront_CD8_block1_x5_y11_patient085_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7e82b25f01bd125dbba1bd41a6664c0dc8034134 --- /dev/null +++ b/085/InvasionFront_CD8_block1_x5_y11_patient085_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 27760.3, + "Num Detections": 10775, + "Num Negative": 10599, + "Num Positive": 176, + "Positive %": 1.633, + "Num Positive per mm^2": 131.96 + } +} \ No newline at end of file diff --git a/085/InvasionFront_CD8_block1_x6_y11_patient085_1.json b/085/InvasionFront_CD8_block1_x6_y11_patient085_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d964eea0b2e7fb14b47337d5cb0673689b3320e7 --- /dev/null +++ b/085/InvasionFront_CD8_block1_x6_y11_patient085_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 27935.2, + "Num Detections": 12560, + "Num Negative": 12555, + "Num Positive": 5, + "Positive %": 0.0398, + "Num Positive per mm^2": 3.729 + } +} \ No newline at end of file diff --git a/085/TumorCenter_CD8_block1_x5_y11_patient085_0.json b/085/TumorCenter_CD8_block1_x5_y11_patient085_0.json new file mode 100644 index 0000000000000000000000000000000000000000..43cfe513a65f49b5131ccefd649d556259cbdcf5 --- /dev/null +++ b/085/TumorCenter_CD8_block1_x5_y11_patient085_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 36405.7, + "Num Detections": 18182, + "Num Negative": 17504, + "Num Positive": 678, + "Positive %": 3.729, + "Num Positive per mm^2": 293.28 + } +} \ No newline at end of file diff --git a/085/TumorCenter_CD8_block1_x6_y11_patient085_1.json b/085/TumorCenter_CD8_block1_x6_y11_patient085_1.json new file mode 100644 index 0000000000000000000000000000000000000000..53872fc2656bf8aa8dc54ccca3e7dbc46f02f210 --- /dev/null +++ b/085/TumorCenter_CD8_block1_x6_y11_patient085_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21613.6, + "Centroid Y µm": 36280.8, + "Num Detections": 15548, + "Num Negative": 15515, + "Num Positive": 33, + "Positive %": 0.2122, + "Num Positive per mm^2": 17.71 + } +} \ No newline at end of file diff --git a/085/history_text.txt b/085/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b6e705b9bd7999dfa0ce15c6d2e56c3633341e80 --- /dev/null +++ b/085/history_text.txt @@ -0,0 +1 @@ +In 2012, the patient received definitive radiochemotherapy up to 72 Gy for hypopharyngeal carcinoma on the left side. The patient subsequently evaded follow-up treatment and presented <2017> with a large mass at the base of the left tongue. Surgical treatment is the only curative treatment option. \ No newline at end of file diff --git a/085/icd_codes.txt b/085/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d5cf959d307e02f273cb309281bfd3d690aada1e --- /dev/null +++ b/085/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] Zytostatische Chemotherapie in der Eigenanamnese[Z92.6 ] \ No newline at end of file diff --git a/085/ops_codes.txt b/085/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4051eb916690e1f136ab8a22f722942097a97084 --- /dev/null +++ b/085/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/085/patient_clinical_data.json b/085/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e9fff19756d511fb452bea93456ce08726f3fd47 --- /dev/null +++ b/085/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 57, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 75, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/085/patient_pathological_data.json b/085/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..102904bed89e20b8c5f6699ad12efa0e8ef6e61c --- /dev/null +++ b/085/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "085", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 8, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/085/surgery_description.txt b/085/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb84fd515cbf69fdc923525abeefba9064824f58 --- /dev/null +++ b/085/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/085/surgery_report.txt b/085/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cb1ea97b90eca4c0bf643ab36c966a09a45e3a82 --- /dev/null +++ b/085/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues. Then sterile washing and draping of the neck. Entry with the Kleinsasser tube and inspection of the hypopharynx and larynx. There is an exophytic mass at the base of the tongue on the left side, which extends down to the pocket fold. The vallecula and epiglottis are completely consumed. The tracheotomy was then performed. Wash down the neck area. Mark the skin incision below the cricoid cartilage, where the apron flap will later be made, and dissect down to the trachea. Dissection of the muscles and insertion between the 2nd and 3rd tracheal cartilage and creation of a visor tracheostomy. Subsequent tracheostoma placement: here dictated by colleagues. Neck dissection on the right and removal of split skin from the right thigh by : Now start of the operation with marking of the skin incisions. These run symmetrically on the left and right side of the neck like an apron flap over the sternocleidomastoid muscle on both sides up to the jugulum. Ending approx. 2 cm from the tracheostoma on both sides. The apron flap is then formed with an incision through the subcutaneous tissue and through the platysma. The platysma is then dissected on both sides in a cranial direction towards the hyoid bone and mandible. Carefully dissect and protect the venous vessels. The neck is massively scarred on both sides following radiochemotherapy. Now simultaneous neck dissection on both sides, left through , right through . Neck dissection on the right: First dissection of the sternocleidomastoid muscle, the omohyoid muscle up to the hyoid bone as well as finding and exposing the posterior digaster venter muscle. Dissection of the anterior edge of the sternocleidomastoid muscle and most careful dissection along the internal jugular vein to the facial vein and dissection of the facial vein. Exposure of the cervical profunda. Exposure of the deep plexus branches and the accessorius nerve. Later exposure of the hypoglossal nerve. Dissection of the common carotid artery and the internal and external carotid arteries. Later exposure of the neck vessels through and . Removal of the sparse lateral and anterior neck dissection. Neck dissection on the left: Then creation of an apron flap in the usual manner, this is already relatively difficult as the neck is severely altered postradiogenically. The patient has an extremely thin platysma. Finally, it is possible to dissect the apron flap upwards. Then start with the neck dissection on the left side. The neck vessels and the entire area are heavily scarred. There is relatively little fatty tissue on both sides of the neck, exposing the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Then exposure of the cervical vascular sheath, this is extremely difficult in the patient due to the scarred conditions. Finally, removal of a very narrow neck preparation while sparing the plexus branches. Removal of the split skin from the right thigh and closure of the forearm wound with suturing of the split skin. by : While lifts the radialis flap on the left and a defect measuring 16 x 10 cm was measured here, the split skin with the dermatome is now removed from the right thigh. To do this, a strip of split skin approx. 20 cm long and a maximum of 7.5 cm wide is first lifted. As this tears slightly in several places, a second strip of split skin approx. 10 cm long and 7.5 cm wide is removed with the dermatome. Then hemostasis with starch powder and Mepilex dressing system. Now suture the split skin on the left forearm. Here, Vicryl 5-0 perichondrium is first sutured over exposed tendons in several places. The subcutaneous suture and the skin suture are then performed proximally in two layers. The longer split skin strip is then sutured in the middle and proximally to distally with 5-0 Ethilon. An additional strip of split skin approx. 6 x 2.5 cm long must then be sutured in on the ulnar side, also with 5-0 Ethilon. Another strip approx. 8 x 3 cm long must be covered with split skin on the radial side. The three pieces of split skin are also sutured together with Ethilon 5-0. Subsequently, relief incisions are made so that any hematoma or seroma can drain away. Preparation swabs are inserted to prevent the graft from lifting and the dressing is applied. Subsequently, combined transoral-transcervical tumor resection: Start with the tumor resection from the transoral side to mark the tumor there. In the area of the base and edge of the tongue, including the anterior palatal arch, a sample was taken and squamous cell carcinoma was found, which meant that most of the palatal arch on the left side had to be removed as well as large parts of the uvula and the tonsil region. Then further dissection from the transcervical side, where 2/3 of the tongue at the base of the tongue had to be resected, leaving only a narrow strip on the right side. However, the lingual artery can be safely preserved and also ensure blood supply to the tongue. The tumor extends caudally into the pocket fold region and also involves the entire epiglottis and the vallecula. This must be removed up to the petiolus. Ultimately, only the level of the vocal folds remains of the larynx and there are no protective mechanisms left to protect the patient from aspiration; this finding is demonstrated intraoperatively on , and . A joint decision is made to remove the larynx. The patient has previously given her verbal consent. This procedure was also discussed verbally with the relevant GP in advance. Then removal of the larynx. The corresponding 15 x 10 cm defect is then covered by with a radial lobe graft. Subsequent removal of the radial lobe by : Attachment of the arm. Measurement of the defect. This has a length of 15 to 16 cm and a width of 10 cm. Flap is planned in its three-dimensional configuration and size and drawn on the forearm. The flap is then first cut radially. Lifting subfascially. Cut to the crook of the elbow. Expose the superficial venous system and connection to the deep venous system. 1 to 2 outlets of the cephalic vein and a good confluence can be visualized. Then cut around the flap radially. Lift off subfascially, taking care to ensure that tissue remains on the tendons, as on the ulnar side. The radial nerve with its ramus cutaneus antebrachii lateralis is preserved as far as possible. Exposure of the radial artery distally. Clamping. Good saturation after an adequately long clamping time. Dissection of the artery, treatment using 4-0 Prolene puncture ligatures. Then lift the flap along the pedicle. Smaller vessels are bipolarly coagulated or clipped. The interosseous artery is first clamped and then clipped while maintaining good saturation. Subsequent exposure of the pedicle vessels. Removal of the veins, which are ligated. Subsequently, the artery, which is supplied with 6-0 Vascufil suture, is removed. Extensive irrigation of the radial artery flap with heparin. Removal of split skin from the thigh area in the corresponding size of the defect. Suturing of the flap by : Successive suturing of the flap. The defect extends from next to the esophageal opening to the nasopharynx. The flap is sutured successively into the defect in the required three-dimensional configuration. Tension-free and complete defect coverage is achieved. The flap is then anastomosed. Both sides of the neck must be explored extensively for this, as the vessels sometimes carry no blood at all or are thrombosed after brief clamping. Finally, the superior thyroid artery on the opposite side can be dissected. This shows good blood flow even after opening and clamping. Slight incision of the lumen of the vessel like a fish mouth. The superior thyroid artery is then anastomosed with the radial artery after appropriate conditioning using 9-0 Ethilon single-button sutures. After opening the clamps, good arterial flow and good venous return. 2 venous anastomoses are created. A large outlet in the area of the confluence is anastomosed with an outlet from the facial vein, after appropriate conditioning, using a 2.5 mm coupler. Outlets at the facialis or smaller outlets in the area of the confluence are clipped. The cephalic vein is trimmed and anastomosed with the external jugular vein. To do this, the external jugular vein must be further mobilized to lengthen it and the sternocleidomastoid muscle must be partially severed to ensure a tension-free anastomosis. This can be created with Coupler 2.0 mm after appropriate conditioning of the veins. Here too, after opening the clamps, as with the previous vein, good venous flow and positive smear phenomenon. Subsequent careful irrigation of the wound area. Intraoperative flap check shows good blood flow. If the site is free of bleeding, the wound is now closed in the typical way in layers with epithelialization of the tracheostoma and insertion of a Redon drain on the left and 2 flaps on the right. Another intraoperative check of the flap transorally. This is well perfused. Then removal of the laryngectomy tube, insertion of an 8-gauge tracheostomy tube and fixation with sutures. The procedure is completed without complications. The patient is transferred to the intensive care unit on a ventilator for monitoring. Please continue the antibiotic treatment, which was started intraoperatively, for 1 week with Unacid. Feeding via the PEG tube for at least 2 weeks, then gruel and, if necessary, cautious diet build-up. Flap control in typical manner for 5 days closely meshed by means of clinical control and Doppler sonography. Total of T4 residual tumor treated by salvage resection and radial flap. \ No newline at end of file diff --git a/086/InvasionFront_CD3_block3_x3_y4_patient086_0.json b/086/InvasionFront_CD3_block3_x3_y4_patient086_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d9a02eeee21ff6bb020882a7347e6843ffb87963 --- /dev/null +++ b/086/InvasionFront_CD3_block3_x3_y4_patient086_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12777.4, + "Centroid Y µm": 15861.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/086/InvasionFront_CD3_block3_x4_y4_patient086_1.json b/086/InvasionFront_CD3_block3_x4_y4_patient086_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69c654dc16a39a8dd90cfa1d034937b2d5baff8a --- /dev/null +++ b/086/InvasionFront_CD3_block3_x4_y4_patient086_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16020.5, + "Centroid Y µm": 15067.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/086/InvasionFront_CD8_block3_x3_y4_patient086_0.json b/086/InvasionFront_CD8_block3_x3_y4_patient086_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fc7ffbdf4da4304763ae60a016512fb65b1e2916 --- /dev/null +++ b/086/InvasionFront_CD8_block3_x3_y4_patient086_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12372.5, + "Centroid Y µm": 9777.6, + "Num Detections": 18529, + "Num Negative": 14484, + "Num Positive": 4045, + "Positive %": 21.83, + "Num Positive per mm^2": 1839.5 + } +} \ No newline at end of file diff --git a/086/InvasionFront_CD8_block3_x4_y4_patient086_1.json b/086/InvasionFront_CD8_block3_x4_y4_patient086_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc4b6ba0474035adf4dc4606514d83dc56272500 --- /dev/null +++ b/086/InvasionFront_CD8_block3_x4_y4_patient086_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15052.9, + "Centroid Y µm": 9676.8, + "Num Detections": 22304, + "Num Negative": 21003, + "Num Positive": 1301, + "Positive %": 5.833, + "Num Positive per mm^2": 540.34 + } +} \ No newline at end of file diff --git a/086/TumorCenter_CD3_block3_x3_y4_patient086_0.json b/086/TumorCenter_CD3_block3_x3_y4_patient086_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a15bbb41bbb4246de4d11b780fdf8fe283bc46a2 --- /dev/null +++ b/086/TumorCenter_CD3_block3_x3_y4_patient086_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 16191.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/086/TumorCenter_CD3_block3_x4_y4_patient086_1.json b/086/TumorCenter_CD3_block3_x4_y4_patient086_1.json new file mode 100644 index 0000000000000000000000000000000000000000..128a06114079982e0ee6248d8b3f6df039bfdcc0 --- /dev/null +++ b/086/TumorCenter_CD3_block3_x4_y4_patient086_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13582.4, + "Centroid Y µm": 16253.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/086/TumorCenter_CD8_block3_x3_y4_patient086_0.json b/086/TumorCenter_CD8_block3_x3_y4_patient086_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d80293180e5100584b5ade75b0ec1f78b20b414 --- /dev/null +++ b/086/TumorCenter_CD8_block3_x3_y4_patient086_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12018.6, + "Centroid Y µm": 11543.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/086/TumorCenter_CD8_block3_x4_y4_patient086_1.json b/086/TumorCenter_CD8_block3_x4_y4_patient086_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e94833a98c261e01470eccfc39a19ed39494340 --- /dev/null +++ b/086/TumorCenter_CD8_block3_x4_y4_patient086_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14592.3, + "Centroid Y µm": 11718.8, + "Num Detections": 9686, + "Num Negative": 9391, + "Num Positive": 295, + "Positive %": 3.046, + "Num Positive per mm^2": 263.37 + } +} \ No newline at end of file diff --git a/086/history_text.txt b/086/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..506c11c34fb7b2852a5637fd49826aa54aab2661 --- /dev/null +++ b/086/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tonsillar carcinoma on the right. Due to the pronounced and penetrating depth, the above-mentioned operation including flap coverage was indicated. \ No newline at end of file diff --git a/086/icd_codes.txt b/086/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adab28f0b88ba31c5bb4895a3d4f3034f2967b3e --- /dev/null +++ b/086/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] \ No newline at end of file diff --git a/086/ops_codes.txt b/086/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ebf37454b33e9cea5008a08c16b2cbc7988ee5af --- /dev/null +++ b/086/ops_codes.txt @@ -0,0 +1 @@ +Exzision Tonsillentumor[5-289.x ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Entnahme eines freien Lappens am Unterarm mit mikrovaskulärer Anastomosierung[5-904.08 L] Selektive Neck dissection in 4 Regionen[5-403.03 L] Selektive Neck dissection in 5 Regionen[5-403.04 R] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Permanente Tracheotomie[5-312.0 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/086/patient_clinical_data.json b/086/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2eff05b0d3737b80cf7b0e765bf6b1c8386a8401 --- /dev/null +++ b/086/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/086/patient_pathological_data.json b/086/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9a1ee51ac05b6310d5e63ad7844be247f8614abc --- /dev/null +++ b/086/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "086", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 38, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/086/surgery_description.txt b/086/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..835d99c576c58a323eb7765f11d4e1f0751905ea --- /dev/null +++ b/086/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Defect coverage, Free flap (Radial), Tracheostomy creation diff --git a/086/surgery_report.txt b/086/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1905312282a04c3f6e6eec8240c816c48d677766 --- /dev/null +++ b/086/surgery_report.txt @@ -0,0 +1 @@ +Pharyngoscopy and laryngoscopy again: confirmation of the extent of the tumor. Then repositioning for surgery: covering of all relevant surgical areas, injection of a total of 10 ml Ultracaine 1% with adrenaline into each side of the neck. Start with transoral tumor resection: insertion of Mc Ivor spatula. Exposure of the tumor. Cut around the tumor with a safety margin of approx. 2 cm along the mucosa. Resection includes anterior palatal arch up to the uvula. Posterior palatal arch can remain. A layer in the pharyngeal region can be dissected without showing tumor infiltration. Resection also includes the glossotonsillar groove along the alveolar ridge and parts of the base of the tongue and extends to the entrance of the hypopharynx. Tumor specimen is removed, thread-marked and sent for frozen section. Mucosal margins free in the frozen section, basal superior and inferior also free, basal medial near the large vessels forming a tumor margin. Therefore, definitive indication for resection of the entire pharyngeal wall and flap coverage. Neck dissection on the right and completion of the tumor resection from transcervical: skin incision in typical manner. Exposure of the sternocleidomastoid anterior wall. Exposure of the omohyoid muscle and digastric muscle. Exposure of the internal jugular vein, the facial nerve with several outlets. Depiction of the internal carotid artery, external carotid artery and several branches. Exposure of the hypoglossal nerve, vagus nerve and accessorius nerve. Subsequent clearing of levels II to V while preserving the branches of the cervical plexus. Some enlarged lymph nodes cranially in levels II to III, macroscopically not clearly suspicious of malignancy. Then completion of the tumor resection from transcervical. The external and internal carotid arteries as well as the hypoglossal nerve and jugular vein are all marked using vessel loops and dissected from the pharyngeal wall. Subsequently, resection of the entire pharyngeal wall from the upper tonsil pole to the beginning of the base of the tongue under external and internal control. The pharynx was also suture-marked there. In the frozen section, there was no tumor here laterally towards the vessels. Thus final R0 resection. Neck dissection is then performed on the left: It is started from and and then completed. As on the opposite side, this is followed by visualization of all structures and level II-IV clearing. No significant enlarged lymph nodes here either. Subsequent tracheostoma placement: small Kocher collar incision here. Dissection through the subcutaneous tissue to the infrahyoid musculature, which is split. Subsequent exposure of the thyroid isthmus. This is passed underneath, clamped off, severed and supplied with puncture ligatures. The anterior surface of the trachea is then exposed. Creation of a broadly pedicled, modified Björk flap. This is then epithelialized in the typical manner to make it virtually tension-free. Then reintubation. Insertion of an 8 mm tracheostomy tube. Tracheotomy was performed by . Flap then removed from the left forearm: After measuring the size approx. 10 x 7 cm, mark the flap in the corresponding size dimension on the left forearm. Skin incision from the crook of the elbow curved to the flap borders, then ulnar. Lift the flap subfascially from the ulnar side. Outgoing vessels are ligated or bipolized or clipped. Subsequent visualization of the superficial vein system. Visualization of a connection between the superficial and deep venous system. Exposure of the pedicle under the brachioradialis muscle. Then recutting of the flap from the ulnar side. Exposure and preservation of the lateral antebrachial cutaneous nerve. Distal exposure of the radial artery, which is first clamped for approx. 10-15 minutes. Always 100% saturation here. The radial artery is then removed. This is treated with 4-0 Prolene sutures proximally and distally using a bypass ligature. Securing suture on the skin area of the flap. The flap is then lifted from caudal to cranial, taking the pedicle with it. Outgoing vessels are ligated or clipped. First clamp the interosseous artery in the elbow area. After consistently good saturation of almost 100 %, clipping or puncture ligation of this. Two outgoing cephalic veins can be seen in the elbow area. The confluence in the area of the radial artery is relatively thin and is also lifted. The flap is then removed. Ligature of the veins, treatment of the edges of the apposition in the area of the brachial artery using 6-0 Vascufil sutures. Flushing of the flap with heparin solution. Split skin is removed from the thigh. This is successively incorporated into the defect on the left forearm. Skin is closed cranially in a typical layered fashion. Subsequent application of octenidine and Mepilex as well as small clouds. Fixation with absorbent cotton. Then fitting of a Cramer splint and fixation of the hand using an elastic bandage. Subsequent application of the hand. Saturation always at 97-100 %, no special features. Then suturing of the radial flap into the defect: This is successively sutured into the defect, which extends from the palatal arch to the base of the tongue or hypopharyngeal entrance. Suturing using 3-0 Vicryl single button sutures, partly under a template. Suturing is complete and tension-free. Then anastomosis of the vessels of the flap. Selection of 2 outlets from the facial vein area. The facial artery is selected for the arterial anastomosis. The facial artery is sutured to the radial artery after conditioning with 8-0 Ethilon single-button sutures. After opening the clamps, good arterial pulse, good venous return, no special features. Subsequent anastomosis of an outlet of the cephalic vein with an outlet from the facial vein using a 3-0 coupler. Again, good venous return after opening the clamp. Positive smear phenomenon. Subsequently, a 2nd outlet from the facial vein is anastomosed with the 2nd outlet from the cephalic vein with a 3.5 mm coupler. No special features here either. Smear phenomenon more positive. Good reflux after opening the clamp. Another small vein is clipped in the area of the flap pedicle. Subsequently, careful positioning of the flap pedicle to prevent kinking. Careful hemostasis is then performed again. Irrigation of the wound area, wound closure in layers on the right side with insertion of 2 flaps. A skin suture is placed in the area of the flap pedicle for Doppler control. On the left side, the skin is closed in the typical layered fashion with the insertion of a Redon drain. The cannula was suture-fixed after insertion. Check of the endaural flap, this is inconspicuously regular. A hydrogel dressing was applied to the thigh area. The procedure was completed without complications. The patient is transferred to the intensive care unit postoperatively on mechanical ventilation. Please continue antibiotic treatment, which was started intraoperatively with Unacid 3 g, for a total of 1 week. Nutrition for 10 days via inserted PEG or already inserted PEG tube. Then swallow gruel and if necessary build up the diet. Flap control typically for 5 days by means of Doppler control, but above all clinically transorally. Please run heparin perfusor 500 E/h for 5 days. Overall cT2-3 tonsillar carcinoma, which infiltrated the wall deeply and therefore required flap coverage. Waiting for histology in the area of the cervical lymph nodes, then presentation at the tumor conference. \ No newline at end of file diff --git a/087/InvasionFront_CD3_block17_x5_y5_patient087_0.json b/087/InvasionFront_CD3_block17_x5_y5_patient087_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fffee65f1101f916c25440d722c5c55ecf7cfacd --- /dev/null +++ b/087/InvasionFront_CD3_block17_x5_y5_patient087_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 17865.5, + "Num Detections": 12632, + "Num Negative": 12456, + "Num Positive": 176, + "Positive %": 1.393, + "Num Positive per mm^2": 116.41 + } +} \ No newline at end of file diff --git a/087/InvasionFront_CD3_block17_x6_y5_patient087_1.json b/087/InvasionFront_CD3_block17_x6_y5_patient087_1.json new file mode 100644 index 0000000000000000000000000000000000000000..43f0d40a0ea9f394720315cd0a6ee1594b65e532 --- /dev/null +++ b/087/InvasionFront_CD3_block17_x6_y5_patient087_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 17940.5, + "Num Detections": 19329, + "Num Negative": 18914, + "Num Positive": 415, + "Positive %": 2.147, + "Num Positive per mm^2": 183.28 + } +} \ No newline at end of file diff --git a/087/InvasionFront_CD8_block17_x5_y5_patient087_0.json b/087/InvasionFront_CD8_block17_x5_y5_patient087_0.json new file mode 100644 index 0000000000000000000000000000000000000000..84b063427c5b9efdf0e4dce787f70f9c3d287ee4 --- /dev/null +++ b/087/InvasionFront_CD8_block17_x5_y5_patient087_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 13018.1, + "Num Detections": 18945, + "Num Negative": 18852, + "Num Positive": 93, + "Positive %": 0.4909, + "Num Positive per mm^2": 38.09 + } +} \ No newline at end of file diff --git a/087/InvasionFront_CD8_block17_x6_y5_patient087_1.json b/087/InvasionFront_CD8_block17_x6_y5_patient087_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9cdcd028c05f9f2d11543c5b47cd37743f2f77c6 --- /dev/null +++ b/087/InvasionFront_CD8_block17_x6_y5_patient087_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 12868.2, + "Num Detections": 17841, + "Num Negative": 17480, + "Num Positive": 361, + "Positive %": 2.023, + "Num Positive per mm^2": 144.9 + } +} \ No newline at end of file diff --git a/087/TumorCenter_CD3_block17_x5_y5_patient087_0.json b/087/TumorCenter_CD3_block17_x5_y5_patient087_0.json new file mode 100644 index 0000000000000000000000000000000000000000..04d515fea6c3683041ac3b5a1ac9161ae0cb3398 --- /dev/null +++ b/087/TumorCenter_CD3_block17_x5_y5_patient087_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 12593.3, + "Num Detections": 17407, + "Num Negative": 17059, + "Num Positive": 348, + "Positive %": 1.999, + "Num Positive per mm^2": 161.08 + } +} \ No newline at end of file diff --git a/087/TumorCenter_CD3_block17_x6_y5_patient087_1.json b/087/TumorCenter_CD3_block17_x6_y5_patient087_1.json new file mode 100644 index 0000000000000000000000000000000000000000..78186b6bc5fc6cc9af6469aaed03b167c58757da --- /dev/null +++ b/087/TumorCenter_CD3_block17_x6_y5_patient087_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 12593.3, + "Num Detections": 17603, + "Num Negative": 17263, + "Num Positive": 340, + "Positive %": 1.931, + "Num Positive per mm^2": 166.26 + } +} \ No newline at end of file diff --git a/087/TumorCenter_CD8_block17_x5_y5_patient087_0.json b/087/TumorCenter_CD8_block17_x5_y5_patient087_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f627bbad2627377274c50ed68eca9d8d89bd6fc5 --- /dev/null +++ b/087/TumorCenter_CD8_block17_x5_y5_patient087_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 26161.1, + "Num Detections": 18441, + "Num Negative": 18056, + "Num Positive": 385, + "Positive %": 2.088, + "Num Positive per mm^2": 176.42 + } +} \ No newline at end of file diff --git a/087/TumorCenter_CD8_block17_x6_y5_patient087_1.json b/087/TumorCenter_CD8_block17_x6_y5_patient087_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d655e95314485e13f0cac797964ac0c5b4ccf981 --- /dev/null +++ b/087/TumorCenter_CD8_block17_x6_y5_patient087_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21463.6, + "Centroid Y µm": 26086.2, + "Num Detections": 18922, + "Num Negative": 18226, + "Num Positive": 696, + "Positive %": 3.678, + "Num Positive per mm^2": 334.0 + } +} \ No newline at end of file diff --git a/087/history_text.txt b/087/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3825818a4ee023b0c265767393a41f88a88f57eb --- /dev/null +++ b/087/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed supraglottic squamous cell carcinoma with extension into the vallecula and caudal tongue base as well as ingrowth into the arytenoid region on the left and medial hypopharyngeal wall on the left. Taking into account the corresponding imaging and the panendoscopic findings, the above-mentioned procedure was indicated with flap coverage. Patient informed about flap coverage, the plan was to remove the radial lobe on the left with a negative Allen test on both sides. \ No newline at end of file diff --git a/087/icd_codes.txt b/087/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..65b9e0267cc0ebc798bead4b0ffb8c020ffc76d0 --- /dev/null +++ b/087/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 B] Bösartige Neubildung sekundär und onA Lymphknoten mehrere Regionen[C77.8 R] \ No newline at end of file diff --git a/087/ops_codes.txt b/087/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d660c4394e585ea9bd86a1fd75417be7e10d8db3 --- /dev/null +++ b/087/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Anlegen einer PEG durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Myotomie M. constrictor pharyngis mit Pharyngotomie[5-299.01 ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Entnahme myokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.23 R] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige Spalthautdeckung am Unterarm[5-902.48 R] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Anlegen anderer Shunt und Bypass Blutgefäße onA mit Prothesenimplantation[5-393.y ] \ No newline at end of file diff --git a/087/patient_clinical_data.json b/087/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2642ff01ed5e410d4fdc56b82f295b3df2e75379 --- /dev/null +++ b/087/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/087/patient_pathological_data.json b/087/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c4037265bdfeaa5ac16f1638983ae51b4b69ccd1 --- /dev/null +++ b/087/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "087", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/087/surgery_description.txt b/087/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b8797f78517ab76f6f69718781b23bfd58f7a0fe --- /dev/null +++ b/087/surgery_description.txt @@ -0,0 +1 @@ +TU resection, Laryngectomy, Flap coverage, Free flap (Radial), PEG, Tracheostomy, and Provox placement diff --git a/087/surgery_report.txt b/087/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..20382b6c48117ce5863b7184161e545333c8a781 --- /dev/null +++ b/087/surgery_report.txt @@ -0,0 +1 @@ +First intubation by the anesthesia colleagues, pharyngoscopy and laryngoscopy again, the tumor is seen growing on the left side pointedly in the direction of the vallecula and lower base of the tongue and as described in the direction of the supraglottic left, including the medial and lateral parts of the arytenoid fold. The upper parts of the hypopharynx on the left medial side are then also included laterally. Right piriform sinus free. Ingrowth into the pre-epiglottic soft tissues probable. Confirmation of the above-mentioned surgical indication. Initially PEG placement after suture insertion. With very good diaphanoscopy, this is successful without any problems. Repeated check of the Allen test. Even after several attempts, the Allen test on the left is positive. Therefore, Allen test on the right, which proves to be correct. Therefore no flap elevation of the radialis flap on the left, but on the right side. This is followed by skin disinfection of all relevant areas. Inject 10 ml into each side of the neck. Sterile draping of all relevant surgical areas. Start with elevation of the apron flap and neck dissection on both sides: (, ). Elevation of the apron flap by and in the usual manner until the submandibular gland and hyoid are exposed. Neck dissectio Regio II to V left through : Exposure of the anterior margin of the sternocleidomastoid muscle. Locate and protect the accessorius nerve. Tracing of the omohyoid muscle and the posterior digastric muscle. Exposure of the gl. submandibularis while preserving the facial vein. Retrograde dissection of the jugulofacial angle and exposure of the jugular vascular sheath. Exposure of the internal jugular vein and the ACC as well as the ACI/ACE and identification of the vagus nerve. This can also be preserved. Exposure and preservation of the plexus branches. Exposure and preservation of the hypoglossal nerve. Clearing of regions II-V on the left side. Final dissection medial to the ACC and start of release of the larynx and transfer to . Right: Exposure of the anterior border of the sternocleidomastoid muscle. Locating and protecting the accessorius nerve. Tracing of the omohyoid muscle and the posterior digastric muscle. Exposure of the gl. submandibularis while preserving the facial vein. Retrograde dissection of the jugulofacial angle and exposure of the jugular vascular sheath. Exposure of the internal jugular vein and the ACC as well as the ACI/ACE and identification of the vagus nerve. This can also be preserved. Exposure and preservation of the plexus branches. Exposure and preservation of the hypoglossal nerve. There are suspicious lymph nodes in region II a and b on the right. These regions are successively removed. Regions III-V on the right side are also removed. A larger, deep-seated arterial vessel is ligated. Now dissection medial to the ACC and start to release the larynx. Subsequent tumor resection with laryngectomy, partial resection of the base of the tongue and partial resection of the pharynx on the left: First detachment of the suprahyoid musculature and the infrahyoid musculature from the hyoid bone. However, part of the suprahyoid musculature is left in place and included in the preparation. This is mainly central. Dissection of the soft tissues up to the supraglottic level is initially omitted. Instead, the infrahyoid musculature is separated and cut caudally. The lymph node fatty tissue of level VI was also dissected and also sent in as a specimen. Caudal transection of the thyroid isthmus. Ligation using stitching sutures. Lateral dissection. Opening of the trachea in the 1st/2nd interspace and then intubation. Insertion of a laryngectomy tube. The caudal trachea is fixed to the skin with 2 sutures. Then expose the superior cornu on both sides. Separation of the constrictor pharyngis from the cartilaginous skeleton. Dissect the piriform sinus more on the right than on the left. Then enter the pharynx on the right at the level of the epiglottis. Exposure of the tumor. Cut around the tumor macroscopically on all sides with a safety margin of at least 1.5 cm. The vallecula initially falls cranially. However, there is still some induration in the vallecula area. Therefore, an approx. 2-3 cm wide strip of mucosa with attached soft tissue is resected from the pharyngeal margin on the right over the base of the tongue to the pharyngeal margin on the left. The sutures are placed close to the tumor and the specimen should be examined away from the tumor. The larynx is developed further caudally while protecting the pharyngeal mucosa as much as possible. Dissection of the distal hypopharyngeal and esophageal entrance. Subsequent removal of the larynx, whereby the trachea is preserved up to the lower edge of the cricoid cartilage in a tongue for suturing. In the cranial pharyngeal region, a marginal sample several mm thick is taken from both the right and left side up to half of the pharynx caudally. These, as well as the entire specimen, are thread-marked for the frozen section margin examination. No evidence of tumor infiltrates in the frozen section in any of the marginal samples. Thus R0 situation. Careful hemostasis and irrigation. Subsequent insertion of a size 10 Provox prosthesis in the typical manner. Then myotomy, whereby the muscles of the constrictor pharyngis are severed on the left side. This significantly improves passage in the esophageal opening. Then elevation of the radial lobe: (): After rechecking the negative Allen test on the right side, draw in the landmarks. Skin incision and dissection of the subcutaneous fatty tissue. This is very thin, so care is taken to leave enough subcutaneous fatty tissue on the skin to avoid necrosis. Dissection of the cephalic vein and exploration of the venous star. Expose and expose the pedicle. Cut around the ulnar side of the 8x8cm flap according to the frozen section result. Palpation of the ulnar artery in depth. Incision of the radial side and radial dissection of the cephalic vein in order to integrate it into the flap. Locate the radial artery distally. Preservation of both branches of the superficial radial nerve. Placement of the graft and irrigation with heparin. At the same time, large areas of split skin are removed from the right thigh in the usual manner. Application of sterile wound dressing in the area of the donor site. Two-layer wound closure in the area of the proximal forearm and suturing of the split skin with relief incisions. Application of a sterile wound dressing and a forearm splint. Completion of the graft lift without complications. Subsequent placement of the right arm. Then insertion of the flap into the defect and vascular anastomosis. Flap is successively sutured into the defect without tension using 4-0 Vicryl single-button sutures. Flap pedicle is transferred to the right side of the neck. Conditioning of the radial artery and a large cephalic vein as well as a small radial vein. Conditioning of the facial vein and a small thyroid vein as well as the facial artery, which is dissected. The facial artery is first anastomosed using 8-0 Ethilon single-button sutures. After opening the clamps, good arterial flow, good venous return. Then anastomosis of the cephalic vein with an outlet of the facial vein using a 3.0 coupler. Then anastomosis of the small V. radialis with the small V. thyroidea media using coupler 1.5. In each case after opening the clamps, good return flow, positive smear phenomenon. Attempt to fix a Doppler flow system to the vein, which was not successful despite several attempts, as the signal was too uncertain. The ultrasound probe is then discarded. Stem is adjusted to prevent kinking. Irrigation of the entire area and careful hemostasis. Subsequent layer-by-layer wound closure with placement of 2 flaps on the right and a Redon drainage on the left and epithelialization of the tracheostoma. Subsequently insertion of a 10 mm tracheostomy tube. The procedure was completed without complications. Patient goes to the intensive care unit for monitoring. Here, please monitor the flap closely clinically by inspecting the flap via the pharynx or by Doppler sonography at the marked site for 5 days. Please continue antibiotics that were started intraoperatively for one week. Feeding via the inserted PEG tube. On the 10th to 12th day, swallow porridge and then build up the diet if necessary. Overall cT4a supraglottic laryngeal carcinoma with infiltration of the vallecula and caudal base of the tongue as well as part of the medial hypopharynx on the left. Suspicious lymph nodes on both sides. Please present postoperatively after receiving the final histology in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/088/InvasionFront_CD3_block12_x3_y1_patient088_0.json b/088/InvasionFront_CD3_block12_x3_y1_patient088_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d05ee4c8a8698c915d232ea528b1bb9f18655b45 --- /dev/null +++ b/088/InvasionFront_CD3_block12_x3_y1_patient088_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12393.4, + "Centroid Y µm": 7371.1, + "Num Detections": 24377, + "Num Negative": 23202, + "Num Positive": 1175, + "Positive %": 4.82, + "Num Positive per mm^2": 442.34 + } +} \ No newline at end of file diff --git a/088/InvasionFront_CD3_block12_x4_y1_patient088_1.json b/088/InvasionFront_CD3_block12_x4_y1_patient088_1.json new file mode 100644 index 0000000000000000000000000000000000000000..12810342c232f2b45f60cb179ed3c5c46e1e14db --- /dev/null +++ b/088/InvasionFront_CD3_block12_x4_y1_patient088_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15017.0, + "Centroid Y µm": 7496.0, + "Num Detections": 22100, + "Num Negative": 21259, + "Num Positive": 841, + "Positive %": 3.805, + "Num Positive per mm^2": 337.3 + } +} \ No newline at end of file diff --git a/088/InvasionFront_CD8_block12_x3_y1_patient088_0.json b/088/InvasionFront_CD8_block12_x3_y1_patient088_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f88fab3e60e78e26a6158d7d7309117e05e8bfbe --- /dev/null +++ b/088/InvasionFront_CD8_block12_x3_y1_patient088_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11493.9, + "Centroid Y µm": 6071.8, + "Num Detections": 26580, + "Num Negative": 26037, + "Num Positive": 543, + "Positive %": 2.043, + "Num Positive per mm^2": 199.31 + } +} \ No newline at end of file diff --git a/088/InvasionFront_CD8_block12_x4_y1_patient088_1.json b/088/InvasionFront_CD8_block12_x4_y1_patient088_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9e6ab2952d3b2a94a8fcc5973f1de8aa6ab919ee --- /dev/null +++ b/088/InvasionFront_CD8_block12_x4_y1_patient088_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14167.5, + "Centroid Y µm": 5946.9, + "Num Detections": 23455, + "Num Negative": 23224, + "Num Positive": 231, + "Positive %": 0.9849, + "Num Positive per mm^2": 93.76 + } +} \ No newline at end of file diff --git a/088/TumorCenter_CD3_block12_x3_y1_patient088_0.json b/088/TumorCenter_CD3_block12_x3_y1_patient088_0.json new file mode 100644 index 0000000000000000000000000000000000000000..636fdc30fe7861220a5066bdd6bb5e9a337dd500 --- /dev/null +++ b/088/TumorCenter_CD3_block12_x3_y1_patient088_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 2573.6, + "Num Detections": 23341, + "Num Negative": 21328, + "Num Positive": 2013, + "Positive %": 8.624, + "Num Positive per mm^2": 810.97 + } +} \ No newline at end of file diff --git a/088/TumorCenter_CD3_block12_x4_y1_patient088_1.json b/088/TumorCenter_CD3_block12_x4_y1_patient088_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7b32fb52a02d5497cd8900e6112a085d6693310f --- /dev/null +++ b/088/TumorCenter_CD3_block12_x4_y1_patient088_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 2523.7, + "Num Detections": 26754, + "Num Negative": 25952, + "Num Positive": 802, + "Positive %": 2.998, + "Num Positive per mm^2": 298.2 + } +} \ No newline at end of file diff --git a/088/TumorCenter_CD8_block12_x3_y1_patient088_0.json b/088/TumorCenter_CD8_block12_x3_y1_patient088_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c133c5995aa53a160881113a1d96dc1044711039 --- /dev/null +++ b/088/TumorCenter_CD8_block12_x3_y1_patient088_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14592.3, + "Centroid Y µm": 11818.7, + "Num Detections": 23780, + "Num Negative": 22666, + "Num Positive": 1114, + "Positive %": 4.685, + "Num Positive per mm^2": 441.67 + } +} \ No newline at end of file diff --git a/088/TumorCenter_CD8_block12_x4_y1_patient088_1.json b/088/TumorCenter_CD8_block12_x4_y1_patient088_1.json new file mode 100644 index 0000000000000000000000000000000000000000..22fb09d98df4d084446ef7b8b426522353d5f063 --- /dev/null +++ b/088/TumorCenter_CD8_block12_x4_y1_patient088_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17165.9, + "Centroid Y µm": 11893.7, + "Num Detections": 25731, + "Num Negative": 25560, + "Num Positive": 171, + "Positive %": 0.6646, + "Num Positive per mm^2": 63.79 + } +} \ No newline at end of file diff --git a/088/history_text.txt b/088/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/088/icd_codes.txt b/088/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6953d8cd46806b3b0ee4498bb82bc4551dc31f3e --- /dev/null +++ b/088/icd_codes.txt @@ -0,0 +1 @@ +Carcinoma, valleculae linguae[C10.0 ] \ No newline at end of file diff --git a/088/ops_codes.txt b/088/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e16326c3c98c5c4ac676b806a86f9e22b1195368 --- /dev/null +++ b/088/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.14 ] Partielle Laryngektomie onA[5-302.y ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Sonstige Entnahme und Transplantation sonstiges Transplantat mit mikrovaskuläre Anastomosierung Oberschenkel und Knie[5-858.x8 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/088/patient_clinical_data.json b/088/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..117c74f3ff849edb5b5a15023b775c9e2bfe9fb7 --- /dev/null +++ b/088/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 44, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/088/patient_pathological_data.json b/088/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a29f6080da8ee70d04772eaa51284b647d2c7e80 --- /dev/null +++ b/088/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "088", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 18.0 +} \ No newline at end of file diff --git a/088/surgery_description.txt b/088/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e4336ba8b23b72ca0d6481af69f07b5e269f811e --- /dev/null +++ b/088/surgery_description.txt @@ -0,0 +1 @@ +TU resection with subtotal ZGru (zygomaticus groove) resection, Epiglottis and pharyngeal partial resection, Defect coverage, Free flap (ALT), Bilateral neck dissection, Tracheotomy diff --git a/088/surgery_report.txt b/088/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..86d6a43904f29e40f2c20841fa23b025d4bda7c4 --- /dev/null +++ b/088/surgery_report.txt @@ -0,0 +1 @@ +CT shows a vallecula carcinoma with extensive infiltration of the base of the tongue and clearly endophytic growth. The decision was therefore made to proceed primarily with transcervical tumor resection. Therefore, in the case of left-sided tumor growth, first turn to neck dissection on the right side: For this purpose, submandibular skin incision with the option of extending a Gluck Sörensen incision. Exposure and transection of the platysma. Creation of a platysma flap. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle. This shows a very pronounced anterior jugular vein. This is dissected and preserved. Dissection of the omohyoid muscle up to the hyoid. Exposure of the submandibular gland, exposure of the digastric muscle. Complete and expose the digastric muscle up to the hyoid. Exposure and preservation of the facial vein. Expose the entire length of the digastric muscle. Now continue dissection of the anterior neck preparation. Expose the cervical artery. Expose the superior thyroid artery. Free preparation to maximum length. Preservation of the cervical artery. Exposure of the hypoglossal nerve. Now expose the accessorius nerve. Free dissection of the internal jugular vein. Level Va now shows several nodes up to about 1 1/2 cm. Careful clearing of the accessorius triangle with careful protection of the nerve. Trace the cervical sinus retrograde via the internal jugular vein and dissect level Va, carefully protecting the cervical plexus. Now remove the digastric muscle. Expose the hyoid horn - release and separate with scissors to widen the access. Now enter latero-cranially of the hyoid horn and perform the pharyngotomy. Widen the pharyngotomy. The extent of the tumor can now be easily palpated. Large parts of the tumor are submucosal. The tumor infiltrates at least 2/3 of the base of the tongue, extends on the left side to the pharyngeal wall, is exulcerated in the area of the vallecula, which is completely consumed. The vallecula is infiltrated and perforated from lingual to laryngeal. Now successive dissection of the tumor, including at least 2/3 of the base of the tongue. Inclusion of the pre-epiglottic fat, which is inconspicuous. Complete release of the epiglottis up to the petiolus. Resection of the left-sided tumor up to the pharyngeal side wall. The tumor ends at the glossotonsillar groove. Cranial macroscopic removal in sano. The specimen is now sent to frozen section diagnostics with the entire specimen thread-marked and is all found to be R0. Only in the area of the base of the tongue on the left is there a maximum basal distance of 0.1 cm. A resection and a final marginal sample are performed here. Now turn to the neck dissection on the opposite side: Here, too, a submandibular skin incision is made. Exposure and transection of the platysma. Creation of a platysma flap. Level II shows a pronounced conglomerate of metastases which, after exposure of the sternocleidomastoid muscle, clearly infiltrates the muscle and also reaches close to the mandible. Now first expose the borders. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle up to the hyoid. A pronounced anterior jugular vein is also well preserved here. Removal of the anterior preparation, the superior thyroid artery can be preserved. Further dissection clearly shows that the lymph node conglomerate in the area of the venous angle clearly infiltrates the internal jugular vein. Therefore, expose the internal jugular vein caudally. Separation of the internal jugular vein and the sternocleidomastoid muscle. Cranial en bloc dissection including level Va. Careful protection of the carotid artery and the vagus nerve. Cranially, the lingual artery and occipital artery must be removed in the area of the external carotid artery after ligation. Involvement of the hypoglossal nerve and accessorius nerve. Cranially, the mass extends close to the mandibular branch. Branches from the oral branch clearly extend into the tumor and are deposited. Here the conglomerate does not reach the submandibular gland. This is skeletonized and left in place. The defect to the pharynx is now visible at the level of the resected hypoglossal nerve. Removal of the internal jugular vein cranially. Parallel to this, elevation of an antero-lateral thigh flap - at the patient's request from the left. A defect measuring a good 7 x 6 cm had already been previously ............. Determination of the perforator line and doppler sonographic identification of 2 equally strong perforators in the midline area. Marking of the graft. Medial skin incision. Separation of the subcutaneous tissue and identification of the rectus femoris muscle. Strictly subfascial dissection. Expansion of the muscle fascia and exposure of the vascular pedicle. Blunt dissection to expose the vascular pedicle in its course. It can now be seen that one perforator runs purely fasciocutaneous, a second one myocutaneous. Performing the relief incision and further dissection and visualization of the vascular pedicle. This is relatively narrow with a clear resection of the base of the tongue. Now subtotal entrainment of the vastus lateralis, entrainment of the muscle while carefully preserving the perforator plane. This is successful with good perforator visibility and in the slim patient. Now dissect the vascular pedicle. Very small caliber vessels can now be seen. Laborious dissection and tracing of the vessels. Exposure of the outlets towards the rectus femoris and transverse outlets towards the vastus lateralis. Slight increase in the caliber of the artery so that it can later be deposited shortly before the outflow of the vessels mentioned. Further dissection of the accompanying veins. Very laborious dissection and hardly any increase in caliber. Several potential veins are now removed and elevated. Prior to this, regular flap control and, if blood flow is good, removal of the graft. Finally, if the site is free of bleeding, insertion of a 10 Redon drain and careful two-layer wound closure after removal of excess skin. Now suture the graft with the aid of sutures. The pharyngeal wall on the left and the entire base of the tongue and the resected supraglottic structures are now reconstructed as a patchplasty. Partially laborious suturing with deliberately sparing pharyngotomy and clearly pronounced muscle cuff. Finally, good graft fit. Microscopic dissection of the vessels. It shows the superior thyroid artery after free preparation in the appropriate caliber size for the flap artery. Due to the position of the planned arterial anastomosis, the decision was made to anastomize the vein with the facial vein. Free preparation of the facial vein with maximum length gain. Performing the arterial anastomosis with 8.0 Ethilon. This works well. Placement of a final suture after reopening the Acland clamp. Regular flow with tight conditions and immediate regular venous return. One venous vessel now has a clear advantage in terms of reflux. Tilt the remaining veins and, after removing the facial vein and exposing the vessel, pass the anastomosis with a size 2.5 coupler. After reopening the Acland clamps, regular flow with immediately good venous return. Padding of the anastomosis with a piece of fat and careful, two-layer wound closure with insertion of a flap. Doppler sonographic identification of the flap pedicle and suture marking. Parallel to this, with dry wound conditions, closure of the left side of the neck after insertion of a 10 Redon drainage with two-layer wound closure. Performing a plastic tracheotomy: Horizontal skin incision for this. Cut through the subcutaneous tissue and expose the infrahyoid musculature. Dissecting the musculature, exposing the thyroid isthmus. Bipolar coagulation of the less pronounced isthmus. Exposure of the anterior surface of the trachea and the cricoid cartilage. Insertion between the 2nd and 3rd tracheal clasp. Creation of a broad-based, pedicled Björk flap and insertion of the mucocutaneous anastomosis. Subsequent problem-free transfer to an 8-gauge cannula with inner core and completion of the procedure at this point. Conclusion: cT4a cN2b-cN2c left vallecular carcinoma with subtotal tongue base resection and epiglottis resection. Intraoperative macroscopic and microscopic R0. Due to the extensive resection of the base of the tongue and the epiglottis resection, the prognosis and swallowing function should be viewed with caution. Prolonged swallowing rehabilitation in any case. If possible, the cannula should be left in place for at least 5 days postoperatively. Regular Doppler sonography and endoscopic checks as usual. \ No newline at end of file diff --git a/089/InvasionFront_CD3_block3_x3_y12_patient089_0.json b/089/InvasionFront_CD3_block3_x3_y12_patient089_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0cc4de352ac030a8167c79264edde2b1af97496d --- /dev/null +++ b/089/InvasionFront_CD3_block3_x3_y12_patient089_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10706.1, + "Centroid Y µm": 36452.4, + "Num Detections": 11488, + "Num Negative": 10999, + "Num Positive": 489, + "Positive %": 4.257, + "Num Positive per mm^2": 356.41 + } +} \ No newline at end of file diff --git a/089/InvasionFront_CD3_block3_x4_y12_patient089_1.json b/089/InvasionFront_CD3_block3_x4_y12_patient089_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e3d7bdcdafdddbc0035c2f34c081f04a6add1a9 --- /dev/null +++ b/089/InvasionFront_CD3_block3_x4_y12_patient089_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13347.3, + "Centroid Y µm": 36830.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/089/InvasionFront_CD8_block3_x3_y10_patient089_0.json b/089/InvasionFront_CD8_block3_x3_y10_patient089_0.json new file mode 100644 index 0000000000000000000000000000000000000000..002939b532077d01384ed72fab19326fef38d752 --- /dev/null +++ b/089/InvasionFront_CD8_block3_x3_y10_patient089_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12393.4, + "Centroid Y µm": 24711.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/089/InvasionFront_CD8_block3_x4_y10_patient089_1.json b/089/InvasionFront_CD8_block3_x4_y10_patient089_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2666dab61c3b27fe0f08eafadc167f735c7205ee --- /dev/null +++ b/089/InvasionFront_CD8_block3_x4_y10_patient089_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14867.1, + "Centroid Y µm": 24711.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/089/TumorCenter_CD3_block3_x3_y10_patient089_0.json b/089/TumorCenter_CD3_block3_x3_y10_patient089_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d88351eb902c03943f496c604918f33c9fcf3455 --- /dev/null +++ b/089/TumorCenter_CD3_block3_x3_y10_patient089_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10698.3, + "Centroid Y µm": 31475.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/089/TumorCenter_CD3_block3_x4_y10_patient089_1.json b/089/TumorCenter_CD3_block3_x4_y10_patient089_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ca597fe540bbc3a40e29f510f5a5a2d1e7480228 --- /dev/null +++ b/089/TumorCenter_CD3_block3_x4_y10_patient089_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13091.8, + "Centroid Y µm": 31377.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/089/TumorCenter_CD8_block3_x3_y10_patient089_0.json b/089/TumorCenter_CD8_block3_x3_y10_patient089_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f031df58e2ea3d66a98a1b6fc4660ccf31894aa6 --- /dev/null +++ b/089/TumorCenter_CD8_block3_x3_y10_patient089_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 26111.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/089/TumorCenter_CD8_block3_x4_y10_patient089_1.json b/089/TumorCenter_CD8_block3_x4_y10_patient089_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5f81dc1bf0704cdcf1cbd4eea2c545499751dc4b --- /dev/null +++ b/089/TumorCenter_CD8_block3_x4_y10_patient089_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 26286.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/089/history_text.txt b/089/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2d2067435eb12a5752afc4bfd6085dc85d8812d6 --- /dev/null +++ b/089/history_text.txt @@ -0,0 +1 @@ +In the patient, a poorly differentiated carcinoma of the right oropharynx was confirmed during a panendoscopy <2012>, with small superficial ulcerative lesions in the area of the pharyngoepiglottic fold and the pharyngeal side wall. Sonographically and on CT, suspected ycN2 neck status with suspected metastases in level VI as well as parapharyngeal metastases, on CT also thickening of the cranial oropharyngeal side wall or tonsillar lobe with unclear depth extension. Previous history of pT2 pN0 anterior floor of mouth carcinoma in 2001 with condition after resection and neck dissection as well as adjuvant interstitial radiotherapy up to 56.5 Gy. Therefore now indication for surgical therapy. \ No newline at end of file diff --git a/089/icd_codes.txt b/089/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..28c4b5c5fda633ad3e00b950e63ba1b5e302d64f --- /dev/null +++ b/089/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Seitenwand des Oropharynx[C10.2 ] Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/089/ops_codes.txt b/089/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..764333c28c8787438dc52166a6cb57d4f6cdaea0 --- /dev/null +++ b/089/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Laserkoagulation Pharynxgewebe[5-292.31 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 6 Regionen[5-403.22 B] Reoperation - Zusatzcode[5-983 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Partielle Parotidektomie ohne Fazialismonitoring[5-262.00 R] \ No newline at end of file diff --git a/089/patient_clinical_data.json b/089/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bb1bb1bbe53bffefd750bd2e800dece454205f52 --- /dev/null +++ b/089/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 48, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/089/patient_pathological_data.json b/089/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0dda9439b82821e4bc6f1488df9dadbbe7f61874 --- /dev/null +++ b/089/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "089", + "primary_tumor_site": "CUP", + "pT_stage": "TX", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 8, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/089/surgery_description.txt b/089/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bbf3390280d62399fa607ee4ad5ea473c15ac90a --- /dev/null +++ b/089/surgery_description.txt @@ -0,0 +1 @@ +Transoral laser resection / Extracapsular dissection of the parotid (Checked in January 2018), Neck dissection, Tracheotomy, PEG diff --git a/089/surgery_report.txt b/089/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..673f68d3c26a733da73863f8eaf83c9a13e7dc7b --- /dev/null +++ b/089/surgery_report.txt @@ -0,0 +1 @@ +After preparation and intubation by the anesthesia colleagues, positioning of the patient. First insertion of the tonsil plug. After inspection of the inconspicuous oral cavity including the inconspicuous primary tumor area, inspection and palpation of the right tonsil lobe. Intact mucosa, no palpable submucosal mass. No correlation to the CT findings. Now consult . Confirmation of the inconspicuous findings in the area of the tonsil lobe or oropharyngeal side wall here, and adjustment of the histologically confirmed findings, which had presented as a small punctate double ulcerative lesion. This can be visualized again under the surgical microscope. Two adjacent, very superficial, small ulcerative lesions are seen in the area of the pharyngoepiglottic fold and pharyngeal side wall with suspected small tumor cones in the direction of the piriform sinus entrance. With good adjustment and inconspicuous endoscopic findings in the area of the tonsil lobe, confirmation of laser resectability. After adjusting the tumor region with the B-tube, resection with the 2.0 watt CO2 laser, submucosal dissection, here tissue on all sides in healthy tissue. Incision of the lesion with a safety margin of approx. 5 mm, but partial resection of the pharyngeal side wall, the entire pharyngoepiglottic fold and the piriform sinus entrance. Basally intact conditions on all sides. Macroscopically hardly any penetration depth. Marginal samples are now taken completely covering the margins. In frozen section diagnostics, the margins of at least CIS are now tumor-free without higher grade dysplasia. Mild to moderate dysplasia in the cranial and dorsal area. After case discussion with , no further measures. Minutious hemostasis and caudal insertion of a Tachosil fleece to prevent bleeding and a pocket. Subsequent PEG insertion: For this purpose, insertion with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach. With excellent diaphanoscopy, problem-free puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. The stomach and oesophagus were unremarkable during the endoscopy. Re-inspection of the resection area. In dry conditions, repositioning for neck dissection, initially on the right side: CT scan showed parapharyngeal tissue plus on the right side, as well as a mass adjacent to the deep parotid pole. In addition, there was also a mass in level VI retroclavicular. Injection of xylocaine with added adrenaline. Opening of the old scar on the anterior edge of the sternocleidomastoid muscle. Cutting through skin and subcutaneous tissue. Exposure and release of the already clearly scarred sternocleidomastoid muscle. Exposure and dissection of the internal jugular vein. This reveals level III or level IV, small nodules up to max. 5 mm. Exposure of the omohyoid muscle. Dissection, visualization of level V. Here, with intact cervical plexus, only scar plate. No further space-occupying lesions. Behind the sternocleidomastoid muscle, in front of the pretracheal musculature or retroclavicularly, a lump measuring approx. 2 x 1 cm with surrounding soft tissue can now be removed without difficulty in correspondence with the CT. The nodule is located on the subclavian vein, which is selectively exposed and safely protected. Nodus macroscopically suspicious. Careful palpation of the supraclavicular region or retroclavicular region, no further masses here. Now dissection and removal of little tissue from the anterior neck area. No suspicious nodules here. Pronounced scarring in the submandibular region. Careful exploration. No further nodules here either. Removal of little lymphatic tissue. Now cranial preparation. Exposure of the caudal parotid pole. A macroscopically clearly suspicious change measuring approx. 2 x 1 cm can be seen on the inner side with a small further attached mass, which is not necessarily suspicious. Mass between the atlas, transverse process and mandible. Removal of the mass with a rim of parotid tissue. A mass also medial to the parotid gland, but this is not necessarily suspicious. Dissection of the parapharyngeal tissue with restrained dissection towards the primary tumor area. Palpation and exploration up to the tonsil lobe. However, no larger masses could be visualized here. Previous exposure of the carotid artery, hypoglossal nerve and accessorius nerve. Protection of the structures. Final palpation of all regions and meticulous hemostasis if there are no visible masses. Wound irrigation with H2O2 and Ringer's solution. Subsequent insertion of a 10-gauge Redon drain and careful two-layer wound closure. Repositioning for neck dissection on the opposite side: the old scar is also used here. Skin incision on the front edge of the sternocleidomastoid muscle. Cut through skin and subcutaneous tissue. Cutting through remnants of the platysma. Exposure of the sternocleidomastoid muscle. Dissection of the scarred muscle. The internal jugular vein was resected during the previous operation. Therefore direct exposure of the common carotid artery. The vagus nerve and the border cord are visualized and are scarred and can be spared over their entire length. Level V is scarred and free with intact cervical plexus and accessorius nerve. Now first caudal dissection. Corresponding to the CT, a macroscopically highly suspicious mass measuring just under 3 x 1 cm, also located on the subclavian vein, can be seen in a similar position as on the opposite side behind the sternocleidomastoid retroclavicular muscle. This is also selectively dissected and spared. Careful palpation of the retroclavicular region. No further space-occupying lesions here. Now, after exposing remnants of the digastric muscle and the submandibular region, exploration. Here too, pronounced scarring, but no further masses. Careful dissection of the caudal parotid gland. Medial exploration. Removal of inconspicuous parapharyngeal tissue. Now medial dissection of the common carotid artery and the bulb in the case of a clearly suspicious parapharyngeal mass on CT. Dissection reveals a longitudinal oval mass measuring approx. 3 x 1 cm between the lateral pharyngeal wall and the carotid artery. This was macroscopically highly suspicious. Caudally a further approx. 1.5 cm also suspicious lump. Palpation of the retro- and parapharyngeal region up to the base of the skull. No further space-occupying lesions here, so that after final palpation, if there are no further nodules and no visible space-occupying lesions, hemostasis and irrigation with H2O2 and bovine solution are also performed. Then, if the wound is dry, a 10-gauge Redon drain is inserted and the wound is carefully closed in two layers. Finally, after a final case discussion with , a plastic tracheostomy is performed and, in the case of a deep primary tumor, a protective tracheostomy. To do this, make a tight incision to avoid fistulation of the tracheostoma with the cervical wound. Cut through skin and subcutaneous tissue. Incision below the cricoid cartilage. Separation of skin and subcutaneous tissue. Longitudinal division of the linea alba. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Dissection of the slender thyroid isthmus. Insertion between the 1st and 2nd tracheal ring. Creation of a broad-based pedicled Björk flap and insertion of the tracheostoma in the usual manner. Subsequent problem-free transfer to a size 8 low-cuff cannula, which was successful. The procedure was then completed without complications. The patient received intraoperative single-shot antibiotics with Unacid 3 g. Conclusion: Intraoperative R0 resected cT1 to cT2 oropharyngeal carcinoma on the right with rcN2c neck status overall conspicuous and highly irregular cervical metastasis on both sides after previous therapy. Due to the clear and irregular metastasis with limited surgical options, adjuvant RCT appears to be indicated. Due to the very discrete primary tumour, field cancerization is also possible. Postoperatively, please leave the protective tracheostomy in place for at least 7 days. Decannulation is then possible if enoral healing is regular and swallowing function is good. \ No newline at end of file diff --git a/090/InvasionFront_CD3_block6_x3_y12_patient090_0.json b/090/InvasionFront_CD3_block6_x3_y12_patient090_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9cdb565af1d5ac3107b51b78e4d9098726c390d7 --- /dev/null +++ b/090/InvasionFront_CD3_block6_x3_y12_patient090_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 31133.5, + "Num Detections": 21497, + "Num Negative": 17794, + "Num Positive": 3703, + "Positive %": 17.23, + "Num Positive per mm^2": 1531.8 + } +} \ No newline at end of file diff --git a/090/InvasionFront_CD3_block6_x4_y12_patient090_1.json b/090/InvasionFront_CD3_block6_x4_y12_patient090_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e9b4abc9390e3175113da4c61381e891349beb0f --- /dev/null +++ b/090/InvasionFront_CD3_block6_x4_y12_patient090_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 31283.4, + "Num Detections": 21153, + "Num Negative": 16841, + "Num Positive": 4312, + "Positive %": 20.38, + "Num Positive per mm^2": 1744.5 + } +} \ No newline at end of file diff --git a/090/InvasionFront_CD8_block6_x3_y10_patient090_0.json b/090/InvasionFront_CD8_block6_x3_y10_patient090_0.json new file mode 100644 index 0000000000000000000000000000000000000000..db346d2cf66923ad77542aa61d91eecd37908f5a --- /dev/null +++ b/090/InvasionFront_CD8_block6_x3_y10_patient090_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11643.8, + "Centroid Y µm": 25211.7, + "Num Detections": 25488, + "Num Negative": 20120, + "Num Positive": 5368, + "Positive %": 21.06, + "Num Positive per mm^2": 1945.8 + } +} \ No newline at end of file diff --git a/090/InvasionFront_CD8_block6_x4_y10_patient090_1.json b/090/InvasionFront_CD8_block6_x4_y10_patient090_1.json new file mode 100644 index 0000000000000000000000000000000000000000..14f0ef24bc98d67b0586e66ad5ad1fe151bd1ac6 --- /dev/null +++ b/090/InvasionFront_CD8_block6_x4_y10_patient090_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14167.5, + "Centroid Y µm": 25386.6, + "Num Detections": 24358, + "Num Negative": 18278, + "Num Positive": 6080, + "Positive %": 24.96, + "Num Positive per mm^2": 2094.5 + } +} \ No newline at end of file diff --git a/090/TumorCenter_CD3_block6_x3_y10_patient090_0.json b/090/TumorCenter_CD3_block6_x3_y10_patient090_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9dea89661fb5cba5760f0316f4ea26774e0371b6 --- /dev/null +++ b/090/TumorCenter_CD3_block6_x3_y10_patient090_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 25461.5, + "Num Detections": 29050, + "Num Negative": 14081, + "Num Positive": 14969, + "Positive %": 51.53, + "Num Positive per mm^2": 5048.1 + } +} \ No newline at end of file diff --git a/090/TumorCenter_CD3_block6_x4_y10_patient090_1.json b/090/TumorCenter_CD3_block6_x4_y10_patient090_1.json new file mode 100644 index 0000000000000000000000000000000000000000..73adc593ff9016cb0001b1020b2f8d2b68e311b4 --- /dev/null +++ b/090/TumorCenter_CD3_block6_x4_y10_patient090_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 25386.6, + "Num Detections": 28529, + "Num Negative": 26608, + "Num Positive": 1921, + "Positive %": 6.733, + "Num Positive per mm^2": 678.29 + } +} \ No newline at end of file diff --git a/090/TumorCenter_CD8_block6_x3_y10_patient090_0.json b/090/TumorCenter_CD8_block6_x3_y10_patient090_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d67f13e95344140fe4b06da1043ff67c54a0020b --- /dev/null +++ b/090/TumorCenter_CD8_block6_x3_y10_patient090_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 25836.3, + "Num Detections": 33903, + "Num Negative": 26363, + "Num Positive": 7540, + "Positive %": 22.24, + "Num Positive per mm^2": 2559.1 + } +} \ No newline at end of file diff --git a/090/TumorCenter_CD8_block6_x4_y10_patient090_1.json b/090/TumorCenter_CD8_block6_x4_y10_patient090_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7f856ded0cd3c326c0be740916bad291e364c18c --- /dev/null +++ b/090/TumorCenter_CD8_block6_x4_y10_patient090_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 25811.3, + "Num Detections": 29885, + "Num Negative": 28980, + "Num Positive": 905, + "Positive %": 3.028, + "Num Positive per mm^2": 318.51 + } +} \ No newline at end of file diff --git a/090/history_text.txt b/090/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..854cb4895b31ab09f0034cb4875737d0413686bf --- /dev/null +++ b/090/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tonsillar carcinoma on the right, histologically squamous cell carcinoma. cN2a status on the right. Therefore, the above-mentioned surgery is now indicated. \ No newline at end of file diff --git a/090/icd_codes.txt b/090/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f976061c3c60b398abb9083da069ed8c87dd77ae --- /dev/null +++ b/090/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, nicht näher bezeichnet[C09.9 ] Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] Halslymphknotenmetastasen[C77.0 R] \ No newline at end of file diff --git a/090/ops_codes.txt b/090/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..50877307df4729e20940a1cb77b6dd97c831f51b --- /dev/null +++ b/090/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Transorale Tumortonsillektomie[5-281.2 ] \ No newline at end of file diff --git a/090/patient_clinical_data.json b/090/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5bdef14bf361af42245216b31a8695bd0943f4db --- /dev/null +++ b/090/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/090/patient_pathological_data.json b/090/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b07e50a9d85ed2e708dec210cb2802256cad5182 --- /dev/null +++ b/090/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "090", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/090/surgery_description.txt b/090/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d7c5864961933ed0308eda85280239e0b76e9b5 --- /dev/null +++ b/090/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy and Right neck dissection diff --git a/090/surgery_report.txt b/090/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b1394d1e0195ec57ca1c84ddbc70f54bb2549b10 --- /dev/null +++ b/090/surgery_report.txt @@ -0,0 +1 @@ +First, the patient is taken to the operating theater and identified. Followed by a consultation with the anesthesia colleagues. Induction of anesthesia and intubation by the anesthesia colleague. Head positioning, insertion of the Mc Ivor mouth spatula, taking the teeth, lips and tongue into account. The tonsil tumor is now removed macroscopically with a safety margin of at least 1-1 1/2 cm to all sides. Suture marking of the tumor as a whole. In addition, a caudal and medial margin sample is taken. The frozen section shows a tumor that has been removed on all sides in healthy tissue. Only medially and caudally is the mucosa somewhat questionable, so a resection is taken here again. Careful hemostasis. Repositioning for neck dissection on the right:: Skin incision on the anterior border of the sternocleidomastoid muscle from mastoid to caudal at the level of the omohyoid muscle. Sharp dissection of the skin subcutaneous tissue and platysma. Exposure of the external jugular vein and transection. Elevation of the subplatysmal flap. Exposure of the submandibular gland, accessorius nerve, internal jugular vein, omohyoid muscle and digastric muscle. There is a large metastasis in level II, which can be easily dissected from the non-lymphatic structures. Removal of the neck specimen from level II to level V while preserving all non-lymphatic structures. Multi-layer wound closure. Platys suture and skin suture with 5-0 Ethilon after placement of a 10-gauge Redon drain. \ No newline at end of file diff --git a/091/InvasionFront_CD3_block6_x3_y7_patient091_0.json b/091/InvasionFront_CD3_block6_x3_y7_patient091_0.json new file mode 100644 index 0000000000000000000000000000000000000000..85ebac75b7a96664e733eb2d652b74dae9fbfc79 --- /dev/null +++ b/091/InvasionFront_CD3_block6_x3_y7_patient091_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11918.7, + "Centroid Y µm": 18315.3, + "Num Detections": 20980, + "Num Negative": 19066, + "Num Positive": 1914, + "Positive %": 9.123, + "Num Positive per mm^2": 735.05 + } +} \ No newline at end of file diff --git a/091/InvasionFront_CD3_block6_x4_y7_patient091_1.json b/091/InvasionFront_CD3_block6_x4_y7_patient091_1.json new file mode 100644 index 0000000000000000000000000000000000000000..72363f698282b6440775cd6ceac9345ddc0b8e2b --- /dev/null +++ b/091/InvasionFront_CD3_block6_x4_y7_patient091_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14592.3, + "Centroid Y µm": 18440.2, + "Num Detections": 20695, + "Num Negative": 18583, + "Num Positive": 2112, + "Positive %": 10.21, + "Num Positive per mm^2": 823.06 + } +} \ No newline at end of file diff --git a/091/InvasionFront_CD8_block6_x3_y5_patient091_0.json b/091/InvasionFront_CD8_block6_x3_y5_patient091_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8b0731b7c49cabb06f9dd9feb42b363d98cc5f02 --- /dev/null +++ b/091/InvasionFront_CD8_block6_x3_y5_patient091_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12418.4, + "Centroid Y µm": 12293.5, + "Num Detections": 18434, + "Num Negative": 16679, + "Num Positive": 1755, + "Positive %": 9.52, + "Num Positive per mm^2": 746.75 + } +} \ No newline at end of file diff --git a/091/InvasionFront_CD8_block6_x4_y5_patient091_1.json b/091/InvasionFront_CD8_block6_x4_y5_patient091_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f3a1d8e003dbf1c33214332f314fd83945c5b5c9 --- /dev/null +++ b/091/InvasionFront_CD8_block6_x4_y5_patient091_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14967.1, + "Centroid Y µm": 12468.4, + "Num Detections": 17471, + "Num Negative": 17118, + "Num Positive": 353, + "Positive %": 2.02, + "Num Positive per mm^2": 169.41 + } +} \ No newline at end of file diff --git a/091/TumorCenter_CD3_block6_x3_y5_patient091_0.json b/091/TumorCenter_CD3_block6_x3_y5_patient091_0.json new file mode 100644 index 0000000000000000000000000000000000000000..549e47e7c844c3dfd503ecb2583d9ef21f5d0c90 --- /dev/null +++ b/091/TumorCenter_CD3_block6_x3_y5_patient091_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11244.0, + "Centroid Y µm": 12843.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/091/TumorCenter_CD3_block6_x4_y5_patient091_1.json b/091/TumorCenter_CD3_block6_x4_y5_patient091_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d17301f6f2431db556c3b38a5890c7ceb8aef2c --- /dev/null +++ b/091/TumorCenter_CD3_block6_x4_y5_patient091_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 12718.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/091/TumorCenter_CD8_block6_x3_y5_patient091_0.json b/091/TumorCenter_CD8_block6_x3_y5_patient091_0.json new file mode 100644 index 0000000000000000000000000000000000000000..46650b1daa5c4d860979472d62484400f229ac38 --- /dev/null +++ b/091/TumorCenter_CD8_block6_x3_y5_patient091_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 13168.0, + "Num Detections": 17468, + "Num Negative": 15696, + "Num Positive": 1772, + "Positive %": 10.14, + "Num Positive per mm^2": 871.69 + } +} \ No newline at end of file diff --git a/091/TumorCenter_CD8_block6_x4_y5_patient091_1.json b/091/TumorCenter_CD8_block6_x4_y5_patient091_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2591536d8543e59475eb5e17d600c37d11274ba7 --- /dev/null +++ b/091/TumorCenter_CD8_block6_x4_y5_patient091_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 12893.2, + "Num Detections": 15987, + "Num Negative": 15003, + "Num Positive": 984, + "Positive %": 6.155, + "Num Positive per mm^2": 557.34 + } +} \ No newline at end of file diff --git a/091/history_text.txt b/091/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/091/icd_codes.txt b/091/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7fd9523b2a03083926554fc9ea5c85857ef0160a --- /dev/null +++ b/091/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Weicher Gaumen[C05.1 ] \ No newline at end of file diff --git a/091/ops_codes.txt b/091/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aa9f03f62f467b29fefcb690cde6e5bc4f017f87 --- /dev/null +++ b/091/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Transplantat[5-295.14 ] Transorale radikale Tonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Entnahme von Vollhaut des Unterarmes[5-901.18 L] Großflächige freie Vollhauttransplantation am Unterarm (Empfängerstelle)[5-902.68 L] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme freier Radialis-Lappen[5-858.23 L] \ No newline at end of file diff --git a/091/patient_clinical_data.json b/091/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..59c1ab51a9e3a378e3da8f1e152e3b94353935e3 --- /dev/null +++ b/091/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 52, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/091/patient_pathological_data.json b/091/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d6df00e048353d7368c06d82c67bfe154e42dfb2 --- /dev/null +++ b/091/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "091", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/091/surgery_description.txt b/091/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..52dc050672458de4e6be729a997852a101e5919f --- /dev/null +++ b/091/surgery_description.txt @@ -0,0 +1 @@ +Total soft palate resection, Bilateral neck dissection, Tracheostomy, Defect coverage, Free flap (Radial) diff --git a/091/surgery_report.txt b/091/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b939f9d15a42b1197f2b6299d22971c0a468151b --- /dev/null +++ b/091/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first infiltration with local anesthetic containing adrenaline in the area of the subsequent incisions for neck dissection. Sterile washing and draping. First perform the tracheostomy. Re-intubation of the patient. This is followed by transoral tumor resection. The entire soft palate is removed. Resection begins at the middle tonsil pole on the right side and extends over the soft palate to the opposite side up to the lower tonsil pole. The tumor is not easily visible macroscopically. After removal of the resectate, the complete resectate is sent for frozen section histology. Carcinoma extensions are still found on the left side paramedian, therefore resection on the left side, starting from the paramedian in the area of the posterior palatal arch. These proved to be free of tumor on frozen section histology. Furthermore, an additional marginal incision is made from the anterior resection margin starting in the middle to the left. This is also free of tumor on frozen section histology, so that an R0 resection can be assumed overall. Subsequently, a radial lobe graft measuring 4 x 9 cm was measured and prepared by and . Elevation of the radial forearm flap: Palpatory identification of the distal radial artery. Marking of the flap borders (9 x 4 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Dissection of a spindle-shaped skin flap from the skin of the proximal forearm, thinning of the skin and suturing in the usual manner to cover the defect on the distal forearm. Application of a forearm splint. Completion of the graft lift without complications. Now perform the neck dissection on the right side. After skin incision and preparation of the cervical vascular nerve sheath, regions II to IV are cleared out while sparing all non-lymphatic structures. Insertion of a Redon suction drain and two-layer wound closure. Transition to neck dissection on the opposite side. In principle, the same procedure is used here. Macroscopically, there is no evidence of lymph node metastasis on either side. Subsequent skeletonization of the hypoglossal nerve and the lingual artery, which will later be used for anastomosis. Creation of the breakthrough into the oropharynx in the lower left tonsil bed. After removal of the radial artery flap graft, it is inserted through the defect into the pharynx and sutured in place The flap is doubled in the middle. The arterial anastomosis of the strong forearm artery on the lingual artery is then performed on the right side. The venous anastomoses are two pieces in an end-to-side manner to the internal jugular vein. Finally, insertion of a Redon suction drain and a drainage flap in the usual manner. Two-layer wound closure. End of the operation, transfer of the patient to anesthesia after placement of a transverse gastric tube, the correct position of which is confirmed by auscultation. Conclusion: Transoral soft palate resection for soft palate carcinoma with primary reconstruction of the microvascular anasatomized radial flap graft from the left forearm. Covering of the defect on the left forearm with full-thickness skin from the same side of the forearm, arterial anastomosis to the lingual artery and two end-to-side veins to the internal jugular vein. Passenger tracheostomy. \ No newline at end of file diff --git a/092/InvasionFront_CD3_block14_x1_y1_patient092_0.json b/092/InvasionFront_CD3_block14_x1_y1_patient092_0.json new file mode 100644 index 0000000000000000000000000000000000000000..45b7e8df45b2706ad46ca93bfcc4c4f644e8a90a --- /dev/null +++ b/092/InvasionFront_CD3_block14_x1_y1_patient092_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5222.2, + "Centroid Y µm": 6171.7, + "Num Detections": 19189, + "Num Negative": 18248, + "Num Positive": 941, + "Positive %": 4.904, + "Num Positive per mm^2": 418.79 + } +} \ No newline at end of file diff --git a/092/InvasionFront_CD3_block14_x2_y1_patient092_1.json b/092/InvasionFront_CD3_block14_x2_y1_patient092_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f6b96ebf5512bf961b85da8280a816131254f595 --- /dev/null +++ b/092/InvasionFront_CD3_block14_x2_y1_patient092_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7895.8, + "Centroid Y µm": 6221.7, + "Num Detections": 22706, + "Num Negative": 22193, + "Num Positive": 513, + "Positive %": 2.259, + "Num Positive per mm^2": 176.7 + } +} \ No newline at end of file diff --git a/092/InvasionFront_CD8_block14_x1_y1_patient092_0.json b/092/InvasionFront_CD8_block14_x1_y1_patient092_0.json new file mode 100644 index 0000000000000000000000000000000000000000..494e8984f6ed02b2e7dc1e11238631fdd042284b --- /dev/null +++ b/092/InvasionFront_CD8_block14_x1_y1_patient092_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5122.3, + "Centroid Y µm": 2598.6, + "Num Detections": 17263, + "Num Negative": 16802, + "Num Positive": 461, + "Positive %": 2.67, + "Num Positive per mm^2": 228.7 + } +} \ No newline at end of file diff --git a/092/InvasionFront_CD8_block14_x2_y1_patient092_1.json b/092/InvasionFront_CD8_block14_x2_y1_patient092_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f2008706aa1dc13a697edca09215f0d70f7b4992 --- /dev/null +++ b/092/InvasionFront_CD8_block14_x2_y1_patient092_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7720.9, + "Centroid Y µm": 2623.6, + "Num Detections": 21782, + "Num Negative": 21587, + "Num Positive": 195, + "Positive %": 0.8952, + "Num Positive per mm^2": 70.99 + } +} \ No newline at end of file diff --git a/092/TumorCenter_CD3_block14_x1_y1_patient092_0.json b/092/TumorCenter_CD3_block14_x1_y1_patient092_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fba7971eb0186d5f4b6f4fce365cf345220988b3 --- /dev/null +++ b/092/TumorCenter_CD3_block14_x1_y1_patient092_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5247.2, + "Centroid Y µm": 2598.6, + "Num Detections": 14890, + "Num Negative": 14804, + "Num Positive": 86, + "Positive %": 0.5776, + "Num Positive per mm^2": 34.02 + } +} \ No newline at end of file diff --git a/092/TumorCenter_CD3_block14_x2_y1_patient092_1.json b/092/TumorCenter_CD3_block14_x2_y1_patient092_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c55798290fccfc3aefc53bcc958d54afcc13691 --- /dev/null +++ b/092/TumorCenter_CD3_block14_x2_y1_patient092_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7646.0, + "Centroid Y µm": 2673.6, + "Num Detections": 17619, + "Num Negative": 17123, + "Num Positive": 496, + "Positive %": 2.815, + "Num Positive per mm^2": 210.11 + } +} \ No newline at end of file diff --git a/092/TumorCenter_CD8_block14_x1_y1_patient092_0.json b/092/TumorCenter_CD8_block14_x1_y1_patient092_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d8720cb0d3087997b6cd24cae2a2385e7a102014 --- /dev/null +++ b/092/TumorCenter_CD8_block14_x1_y1_patient092_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.1, + "Centroid Y µm": 3448.2, + "Num Detections": 19436, + "Num Negative": 19418, + "Num Positive": 18, + "Positive %": 0.0926, + "Num Positive per mm^2": 7.136 + } +} \ No newline at end of file diff --git a/092/TumorCenter_CD8_block14_x2_y1_patient092_1.json b/092/TumorCenter_CD8_block14_x2_y1_patient092_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2fe3efb4f24b3a6515f0b9815781f11bfaca83ec --- /dev/null +++ b/092/TumorCenter_CD8_block14_x2_y1_patient092_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 3423.2, + "Num Detections": 20780, + "Num Negative": 20552, + "Num Positive": 228, + "Positive %": 1.097, + "Num Positive per mm^2": 89.38 + } +} \ No newline at end of file diff --git a/092/history_text.txt b/092/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..db3c3b14d18c7c0116ce0dd4dc601ac24182d9b1 --- /dev/null +++ b/092/history_text.txt @@ -0,0 +1 @@ +Z. n. pT1pN0 tongue margin carcinoma right <2017>. Now they tMonths feeling of pressure on the left side of the tongue. CT scan shows a contrast-absorbing mass on the left edge of the tongue. \ No newline at end of file diff --git a/092/icd_codes.txt b/092/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/092/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/092/ops_codes.txt b/092/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..82ddc989ad02bebb4eb98b72414ac4b24be4eafc --- /dev/null +++ b/092/ops_codes.txt @@ -0,0 +1 @@ +Zungenteilresektion onA[5-251.y ] Transplantat[5-295.04 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Ösophagoskopie[1-630.x ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Temporäre Tracheotomie[5-311.0 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Sonstige Entnahme von Vollhaut[5-901.1x L] Kleinflächige freie Vollhauttransplantation am Unterarm[5-902.28 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/092/patient_clinical_data.json b/092/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b6ecedfb31708c75a1df818a04b9ff327c1a10c9 --- /dev/null +++ b/092/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 39, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/092/patient_pathological_data.json b/092/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e2d374ba61077e99661154e730b9fadface557ad --- /dev/null +++ b/092/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "092", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/092/surgery_description.txt b/092/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..24abec23f91dc360a7163568ffbca838e15dbf2e --- /dev/null +++ b/092/surgery_description.txt @@ -0,0 +1 @@ +Transoral TU resection, Left neck dissection, Tracheotomy diff --git a/092/surgery_report.txt b/092/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b120e5b927e6e26d120013cc999d959e70c6841f --- /dev/null +++ b/092/surgery_report.txt @@ -0,0 +1 @@ +Dictation : After appropriate preparation, first disinfect the skin. Infiltration with local anesthetic containing adrenaline in the area of the subsequent skin incision. First perform the tracheoscopy. After skin incision, dissection in the median plane through the linea alba onto the isthmus, which is passed underneath. The isthmus is then ligated so that the first 5 tracheal clips can be visualized. Subsequently, visual tracheostomy between the 3rd/4th tracheal clasp with reintubation of the patient. Completion of the mucocutaneous anastomosis with 2 sutures each cranially and caudally. Subsequent reintubation of the patient. Now adjust the tumor with the 2nd mouth retractor. Tightening of the tip of the tongue. The tumor is palpable in the posterior quarter of the tongue on the left side in the area of the glossotonsillar groove. Start with dorsal tumor resection, whereby the resection incision is made in the upper third of the tonsil bed and is initially made laterally up to the lower jaw. The tumor area is then resected by palpation at a distance of 1-2 cm towards the front and middle. Thus, under constant palpatory control and at an appropriate safety distance, the tumor is successively separated from the body of the tongue, initially the lateral floor of the mouth, as well as the base of the tongue using the ultrasonic knife. The hypoglossal nerve and the lingual nerve are severed. Finally, the tumor-bearing tissue block can be removed in toto. Macroscopically, the tumor is surrounded on all sides by musculature. Removal of marginal incisions circularly around the defect as well as from the tumor base. These all proved to be tumor-free, only the back of the tongue and the anterior floor of the mouth showed moderate dysplasia, so that resections were carried out here, but these were free of further dysplasia. These areas were also previously furthest away from the tumor, so there is certainly no connection with the tumor here. The main specimen is also examined using frozen section histology and is also found to be R0 in depth into the musculature. Subsequent sterile washing and draping. Transition to neck dissection on the left. After skin incision, regions II to V are successively removed while preserving all non-lymphatic structures. Then evacuation of regions Ia and b and removal of the submandibular gland, with automatic access to the oropharynx. Dissection of the digastric muscle. Dissection of the facial vein as well as a vein located further caudally for subsequent anastomosis. The superior thyroid artery is also dissected, but its caliber is quite small. Therefore, the facial artery is also dissected up to the mandible for later anastomosis. Dictation : Acceptance of the operation by . Marking of the graft on the forearm 10.5 x 6.5 cm, which was measured by . Start with the flap elevation on the left forearm using and . Expose the brachioradialis muscle for this. Exposure of the cephalic vein. Visualization of the venous star in the antecubital fossa. Exposure of the confluence. Incision of the graft. Exposure of the superficial ramus of the radial nerve. Exposure of the radial artery, resulting in tearing of a branch from the superficial ramus of the radial nerve that runs to the thumb. This is sutured with 8.0 Prolene. Lifting of the graft from the tendon bed. Dissection of the pedicle up to the crook of the elbow. Removal of the pedicle with two superficial and two deep veins and flushing of the graft with heparin in the usual manner. Removal of full-thickness skin directly from the forearm and thinning of this full-thickness skin. Then preparation of the wound bed on the forearm by approximating the wound edges in the graft harvesting area. Then suturing of the full-thickness skin in the usual manner and turning to the oropharynx and the oral cavity. Inspection of the site again. Hemostasis. It is now clear that the defect is larger than expected and extends to the vallecula in the caudal region. This defect was partially primarily adapted here by and the soft palate was also partially closed by , in which a part of the healthy side including the uvula was sutured to the left. In the caudal area where the partial primary wound closure in the pharynx took place, a second suture was applied to close the area more tightly. Now insert the flap and start suturing. This is relatively difficult as the graft is quite small for the large defect. In the end, the graft was successfully sutured into place. The stalk was removed into the neck. Then anastomosis between the radial artery and facial artery and anastomosis of the veins through two couplers at the outlets of the internal jugular vein. Insertion of a Penrose drain and two-layer wound closure. The patient is ventilated and admitted to the intensive care unit. Please continue flap checks according to the usual schedule and antibiotics for at least 24 hours. \ No newline at end of file diff --git a/093/InvasionFront_CD3_block11_x1_y10_patient093_0.json b/093/InvasionFront_CD3_block11_x1_y10_patient093_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e645ee3a359e1f777d3c414ced5af92397ed4551 --- /dev/null +++ b/093/InvasionFront_CD3_block11_x1_y10_patient093_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 24562.0, + "Num Detections": 20676, + "Num Negative": 12725, + "Num Positive": 7951, + "Positive %": 38.46, + "Num Positive per mm^2": 3189.9 + } +} \ No newline at end of file diff --git a/093/InvasionFront_CD3_block11_x2_y10_patient093_1.json b/093/InvasionFront_CD3_block11_x2_y10_patient093_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cf24aa88e4d044e419806035199129e6ce391208 --- /dev/null +++ b/093/InvasionFront_CD3_block11_x2_y10_patient093_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6246.7, + "Centroid Y µm": 24412.1, + "Num Detections": 22882, + "Num Negative": 15498, + "Num Positive": 7384, + "Positive %": 32.27, + "Num Positive per mm^2": 2917.9 + } +} \ No newline at end of file diff --git a/093/InvasionFront_CD8_block11_x1_y10_patient093_0.json b/093/InvasionFront_CD8_block11_x1_y10_patient093_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8318a339b0dd412f4863e3595ec4579b70d4a0a5 --- /dev/null +++ b/093/InvasionFront_CD8_block11_x1_y10_patient093_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6453.4, + "Centroid Y µm": 35586.5, + "Num Detections": 19508, + "Num Negative": 8426, + "Num Positive": 11082, + "Positive %": 56.81, + "Num Positive per mm^2": 4596.8 + } +} \ No newline at end of file diff --git a/093/InvasionFront_CD8_block11_x2_y10_patient093_1.json b/093/InvasionFront_CD8_block11_x2_y10_patient093_1.json new file mode 100644 index 0000000000000000000000000000000000000000..80f56f6cdb870709a7943c973392ce4deb7a72c3 --- /dev/null +++ b/093/InvasionFront_CD8_block11_x2_y10_patient093_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8988.9, + "Centroid Y µm": 35510.3, + "Num Detections": 19381, + "Num Negative": 11110, + "Num Positive": 8271, + "Positive %": 42.68, + "Num Positive per mm^2": 3432.7 + } +} \ No newline at end of file diff --git a/093/TumorCenter_CD3_block11_x1_y10_patient093_0.json b/093/TumorCenter_CD3_block11_x1_y10_patient093_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5f32d79280105ae816b7a50d7eba18f897f2ff9a --- /dev/null +++ b/093/TumorCenter_CD3_block11_x1_y10_patient093_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 24312.1, + "Num Detections": 22388, + "Num Negative": 9639, + "Num Positive": 12749, + "Positive %": 56.95, + "Num Positive per mm^2": 4863.1 + } +} \ No newline at end of file diff --git a/093/TumorCenter_CD3_block11_x2_y10_patient093_1.json b/093/TumorCenter_CD3_block11_x2_y10_patient093_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8746cea0e65d8e9e9c51a55cfc0ce5a7d8dbf447 --- /dev/null +++ b/093/TumorCenter_CD3_block11_x2_y10_patient093_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8820.3, + "Centroid Y µm": 24437.1, + "Num Detections": 21816, + "Num Negative": 10208, + "Num Positive": 11608, + "Positive %": 53.21, + "Num Positive per mm^2": 4666.2 + } +} \ No newline at end of file diff --git a/093/TumorCenter_CD8_block11_x1_y10_patient093_0.json b/093/TumorCenter_CD8_block11_x1_y10_patient093_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7ff0146a90506fea59c9c800ab47af29df403bbf --- /dev/null +++ b/093/TumorCenter_CD8_block11_x1_y10_patient093_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 24412.1, + "Num Detections": 20952, + "Num Negative": 2682, + "Num Positive": 18270, + "Positive %": 87.2, + "Num Positive per mm^2": 6653.2 + } +} \ No newline at end of file diff --git a/093/TumorCenter_CD8_block11_x2_y10_patient093_1.json b/093/TumorCenter_CD8_block11_x2_y10_patient093_1.json new file mode 100644 index 0000000000000000000000000000000000000000..db798e15bfe2c8b065c00effb5de691efe9dd0ab --- /dev/null +++ b/093/TumorCenter_CD8_block11_x2_y10_patient093_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 24387.1, + "Num Detections": 18938, + "Num Negative": 5076, + "Num Positive": 13862, + "Positive %": 73.2, + "Num Positive per mm^2": 5407.8 + } +} \ No newline at end of file diff --git a/093/history_text.txt b/093/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4ed804eaa400cbbee1801eacdc2771379774d9ef --- /dev/null +++ b/093/history_text.txt @@ -0,0 +1 @@ +The patient has a confirmed, poorly differentiated cT3 cN1 tonsillar carcinoma on the left, which is histologically clearly associated with HBV. \ No newline at end of file diff --git a/093/icd_codes.txt b/093/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2770660c26e82cc7a5e928e61e1ef4528738e535 --- /dev/null +++ b/093/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Fossa tonsillaris[C09.0 ] \ No newline at end of file diff --git a/093/ops_codes.txt b/093/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d51ba55505939e5fac64752c58846346ea507339 --- /dev/null +++ b/093/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Tonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 6 Regionen[5-403.05 B] Resektion an der Trachea mit Anlegen eines Tracheostomas[5-314.12 ] Transplantation sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.93 L] Transplantat[5-295.04 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] \ No newline at end of file diff --git a/093/patient_clinical_data.json b/093/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..22dac7ad1bd4534d69cb122be0148868ec55e27b --- /dev/null +++ b/093/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 40, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/093/patient_pathological_data.json b/093/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2b9360403c82798b6873730ab3fa8a8a7e1ec2ff --- /dev/null +++ b/093/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "093", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/093/surgery_description.txt b/093/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0bc5daf9a84b42f1d700b8d09a1da26da3555465 --- /dev/null +++ b/093/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Right tonsillectomy, Bilateral neck dissection, Defect coverage, Free flap (Radial), Plastic tracheotomy, PEG diff --git a/093/surgery_report.txt b/093/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0a8864d331aa32f7ffbeb77af646ebe1a0a31d1a --- /dev/null +++ b/093/surgery_report.txt @@ -0,0 +1 @@ +Start with insertion of the PEG tube: Perform flexible gastroscopy for this purpose. Enter with the gastroscope under laryngoscopic control. Problem-free pre-scanning into the stomach. If the diaphansocopy is very good, puncture the stomach without any problems and pull the PEG tube through using the usual suture pull-through method. Inconspicuous esophagus on reflection. Then turn to enoral tumor resection: inspection. The entire left tonsil is found to be tumorously bulging submucosally, the tumor extends close to the uvula, infiltrates the soft palate and extends up to about 1/3 of the posterior pharyngeal wall. The tumor extends towards the buccal and alveolar ridge as well as to the pharyngeal side wall at the level of the hypopharyngeal entrance, transition to the glossotonsillar groove. Contrary to the CT image, the base of the tongue itself is not infiltrated. Now cut around the tumor with the monopolar with a safety margin of at least 1 cm in case of growth into the left uvula base. Subtotal resection of the soft palate. Dissection shows that the tumor has a kind of pseudocapsule and appears relatively well encapsulated. Further excision of the tumor with sufficient safety distance using the dissection technique. Resection close to the alveolar ridge in the posterior region of the molars. All-round removal of the tumor macroscopically in healthy tissue. The carotid artery can be palpated in depth, but no direct contact. In the area of the posterior pharyngeal wall, a good displacement layer is already visible above the deep cervical fascia. The tumor can be released in its entirety here. Resection of the right posterior pharyngeal wall via the midline. Resection circumscribed in the area of the glossotonsillar groove, as described above, no infiltration of the base of the tongue. The tumor specimen is thread-marked for final histology. Clearly representative marginal samples are now taken in the entire adjacent mucosal area as well as basally in the area of the upper tonsil pole and in the area of the pharyngeal musculature. Macroscopic resection is most likely here. In frozen section diagnostics, all marginal samples are found to be tumor-free. The result is a subtotal soft palate defect with a defect in the posterior pharyngeal wall extending beyond the midline and to the lateral pharyngeal wall in the area of the transition to the hypopharynx. In addition, circumscribed resection of the glossotonsillar groove and the posterior floor of the mouth. Resection of the right tonsil using the dissection technique, meticulous hemostasis. A defect measuring a maximum of 11 x 7 cm is now measured and an appropriately configured radialis graft is designed. From here, parallel preparation of the neck dissection and the radial distal graft. First for the neck dissection - start with the right side: make a submandibular curved incision. Cut through the skin and the subcutis. Exposure of the platysma. Dissection of the platysma. Creation of a platysmal flap. Exposure of the external jugular vein and the auricular nerve. Sparing of the structures. Exposure of the anterior border of the sternocleidomastoid muscle. Free preparation of the muscle and exposure of the omohyoid muscle. Freeing of the muscle up to the hyoid. Exposure of the submandibular gland. Complete the anterior direction of the hyoid. Expose the entire length of the digaster muscle. Now continue exposing the neck preparation anteriorly. Expose the cervical anus. Expose and preserve the facial vein, expose the hypoglossal nerve and the superior thyroid artery. Now dissect dorsally. Release the accessorius triangle while carefully preserving the nerve and complete level Va while carefully preserving the cervical plexus. Final inspection and, if the wound is dry, insertion of a 10 Redon drain and careful, two-layer wound closure. All the anatomical structures mentioned here were preserved. Now turning to the opposite side: Here, the same procedure was followed in principle. After creating a platysmal flap, expose the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digastric nerve. During dissection of the internal jugular vein, several tributaries to the internal jugular vein are visible here (as well as on the opposite side) in addition to the facial vein. These are all spared. In the area of the jugulo-facial angle, a lymph node of conspicuous size and shape is now visible on the left. Release the specimen anteriorly while also sparing and exposing the hypoglossal nerve, cervical artery and superior thyroid artery. Complete the neck dorsally while carefully protecting the accessorius nerve and the cervical plexus. Now remove the digastric muscle. Further dissection and performance of a pharyngotomy below the tonsil lobe. Creation of an approx. 3-finger wide access. Radialis graft: First identify the cephalic vein. Marking of the graft. A skin monitor is also lifted. Application of the tourniquet to 300 mmHg. Skin incision and preparation of a skin flap while carefully preserving the subcutaneous vascular tissue. Exposure of the cephalic vein. Strictly subfascial dissection and performance of the Hayden maneuver. Identification of the superficial ramus and radial nerve. Both branches can be exposed and preserved. Now expose the vascular pedicle. Blunt exposure of the radial artery with its accompanying veins. Ligation of the vascular pedicle. Now successive lifting of the graft under strictly subfascial preparation. Develop the graft cranially while carefully supplying the feeding vessels. A classic vein pattern with cubital outlet of the cephalic vein can be seen in the area of the antecubital fossa. In the area of the cubital fossa, the anatomy is also classic with a regular outlet of the interosseous artery and the ulnar artery. A broad vascular bridge of the deep venous area of the radial artery and the superficial outflow area can now also be seen. Now open the tourniquet. Minutious hemostasis. Regular or excellent flap perfusion with regular arm perfusion. Deposition of the graft after ligation of the remaining draining and supplying vessels. Then removal of full-thickness skin from the right groin. Skin incision for this. Strict cutaneous preparation. Careful hemostasis and, after skin mobilization, careful, multi-layered subcutaneous closure with moderate tension and skin suturing. Prior to this, insertion of a 10 Redon drain. Now inspection of the forearm. Final hemostasis and, if the wound is dry, careful two-layer wound closure and insertion of the full-thickness skin graft and final treatment with a vacuum sealing dressing and application of the Cramer splint. Now to the suturing of the graft. Start suturing the graft transorally. First suturing of the dorsal resection border, suturing of the palatal arch replacement in the area of the tonsil lobe, especially in the area of the transition to the glossotonsillar groove and the posterior floor of the mouth. Extremely difficult suturing conditions, also in the area of the pharyngeal side wall. Difficult suturing due to poor accessibility, but finally a tight and gap-free fit. The caudal end of the flap must be sutured in transcervically. Here, after exposing the pharyngotomy, relatively problem-free suturing. Here too, good adaptation with an overall adequate flap size. Now turn to the vascular anastomosis. The superior thyroid artery is further exposed, clamped and dissected free. Vascular anastomosis with 8.0 Ethilon. Slightly more difficult due to the position of the vessel, but overall without complications. After opening the clamp, good and tight vascular anastomosis with good flow and good venous return. Now select the venous vessel with the better return flow. Clip the 2nd vein. Measure a 2.5 mm coupler. Expose and carefully dissect the facial venous branch. Deposition after clipping and coupler anastomosis. In this case, the posterior part of the coupler cannot be placed correctly so that a sufficient anastomosis cannot be created. The coupler must therefore be removed. At the next attempt, coupler placement without complications, also with 2.5 mm density and sufficient anastomosis with good arterial and venous flow. Regular blood supply to the skin monitor, so that after flap application, the wound was carefully closed in two layers in dry wound conditions. A tracheotomy had already been performed previously due to the size of the defect, the size of the flap and the tongue swelling that occurred during the incision. For this purpose, the skin incision was made horizontally, sparingly below the cricoid cartilage. Dissection of the subcutaneous tissue. Exposure of the infrahyoid musculature. Splitting of the musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea and insertion between the 2nd and 3rd tracheal ring. Creation of a Björk flap and performance of the mucocutaneous anastomosis. Finally, problem-free reintubation to an 8-gauge cannula with inner core and completion of the procedure, overall without any indication of complications. Conclusion: R0 resection of a cT3 cN1 tonsillar carcinoma on the left. The antibiotic treatment with Unacid 3 g started intraoperatively should be continued for at least 24 hours. The sutured cannula should be left in place until the 5th postoperative day. Leave the Cramer splint and Vac bandage in place for 7 days. A diet can be started from the 8th postoperative day if the flap is healing well. However, findings should be checked by the surgeon beforehand. \ No newline at end of file diff --git a/094/InvasionFront_CD3_block13_x3_y2_patient094_0.json b/094/InvasionFront_CD3_block13_x3_y2_patient094_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e6eefd61f18b972c42dfea543baa2152dfee0414 --- /dev/null +++ b/094/InvasionFront_CD3_block13_x3_y2_patient094_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11094.1, + "Centroid Y µm": 4497.6, + "Num Detections": 16969, + "Num Negative": 16647, + "Num Positive": 322, + "Positive %": 1.898, + "Num Positive per mm^2": 172.94 + } +} \ No newline at end of file diff --git a/094/InvasionFront_CD3_block13_x4_y2_patient094_1.json b/094/InvasionFront_CD3_block13_x4_y2_patient094_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dc63f805c202de1e73298ecb0a7593c0400a8607 --- /dev/null +++ b/094/InvasionFront_CD3_block13_x4_y2_patient094_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 4472.6, + "Num Detections": 18066, + "Num Negative": 17550, + "Num Positive": 516, + "Positive %": 2.856, + "Num Positive per mm^2": 258.52 + } +} \ No newline at end of file diff --git a/094/InvasionFront_CD8_block13_x3_y2_patient094_0.json b/094/InvasionFront_CD8_block13_x3_y2_patient094_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0246535181a5f5653433a04a3df9f198c310320b --- /dev/null +++ b/094/InvasionFront_CD8_block13_x3_y2_patient094_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12718.3, + "Centroid Y µm": 5996.8, + "Num Detections": 18832, + "Num Negative": 18453, + "Num Positive": 379, + "Positive %": 2.013, + "Num Positive per mm^2": 195.07 + } +} \ No newline at end of file diff --git a/094/InvasionFront_CD8_block13_x4_y2_patient094_1.json b/094/InvasionFront_CD8_block13_x4_y2_patient094_1.json new file mode 100644 index 0000000000000000000000000000000000000000..375c520e670ad3b3b86aa8f300b6c8bfe96e0246 --- /dev/null +++ b/094/InvasionFront_CD8_block13_x4_y2_patient094_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15291.9, + "Centroid Y µm": 6121.8, + "Num Detections": 18779, + "Num Negative": 18327, + "Num Positive": 452, + "Positive %": 2.407, + "Num Positive per mm^2": 219.02 + } +} \ No newline at end of file diff --git a/094/TumorCenter_CD3_block13_x3_y2_patient094_0.json b/094/TumorCenter_CD3_block13_x3_y2_patient094_0.json new file mode 100644 index 0000000000000000000000000000000000000000..047ba43f04f57b1aa1d2429d2b7b7d05d9f1ecb8 --- /dev/null +++ b/094/TumorCenter_CD3_block13_x3_y2_patient094_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12743.3, + "Centroid Y µm": 11568.9, + "Num Detections": 17632, + "Num Negative": 16624, + "Num Positive": 1008, + "Positive %": 5.717, + "Num Positive per mm^2": 508.97 + } +} \ No newline at end of file diff --git a/094/TumorCenter_CD3_block13_x4_y2_patient094_1.json b/094/TumorCenter_CD3_block13_x4_y2_patient094_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4fd5b1b2abe32f7ecf7d532dfa65ea02414295bd --- /dev/null +++ b/094/TumorCenter_CD3_block13_x4_y2_patient094_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15241.9, + "Centroid Y µm": 11693.8, + "Num Detections": 16916, + "Num Negative": 15944, + "Num Positive": 972, + "Positive %": 5.746, + "Num Positive per mm^2": 505.14 + } +} \ No newline at end of file diff --git a/094/TumorCenter_CD8_block13_x3_y2_patient094_0.json b/094/TumorCenter_CD8_block13_x3_y2_patient094_0.json new file mode 100644 index 0000000000000000000000000000000000000000..18851fe6e6ef878e1d2b633e064ce2e8b3c22f2f --- /dev/null +++ b/094/TumorCenter_CD8_block13_x3_y2_patient094_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10494.4, + "Centroid Y µm": 5747.0, + "Num Detections": 16174, + "Num Negative": 16027, + "Num Positive": 147, + "Positive %": 0.9089, + "Num Positive per mm^2": 75.08 + } +} \ No newline at end of file diff --git a/094/TumorCenter_CD8_block13_x4_y2_patient094_1.json b/094/TumorCenter_CD8_block13_x4_y2_patient094_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0463970992692aed6506862d6aa9fa8204d4fef2 --- /dev/null +++ b/094/TumorCenter_CD8_block13_x4_y2_patient094_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12943.1, + "Centroid Y µm": 5297.2, + "Num Detections": 13504, + "Num Negative": 13181, + "Num Positive": 323, + "Positive %": 2.392, + "Num Positive per mm^2": 183.6 + } +} \ No newline at end of file diff --git a/094/history_text.txt b/094/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9c425665cf8d53e7b7a97f757b7303cc7180fc26 --- /dev/null +++ b/094/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT3 supraglottic laryngeal carcinoma on the left was histologically confirmed during a panendoscopy, aryfixation and fixation of the left hemilarynx. Sonographically, there was evidence of a cN2a neck status. In our interdisciplinary tumor conference, primary surgical treatment with laryngectomy was recommended. After extensive consultations, a joint decision was made with the patient on primary surgical treatment. \ No newline at end of file diff --git a/094/icd_codes.txt b/094/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/094/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/094/ops_codes.txt b/094/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a62da950167388f8f9967da2f35372f7f2f6edd6 --- /dev/null +++ b/094/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie und Schilddrüsenresektion mit Rekonstruktion mit lokaler Schleimhaut[5-303.21 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] \ No newline at end of file diff --git a/094/patient_clinical_data.json b/094/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bca0419383fd4e47e3a404ca33430695dc655640 --- /dev/null +++ b/094/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 36, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/094/patient_pathological_data.json b/094/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..46c5d6a4e41c26dc23eac72f21d09271ad0d4742 --- /dev/null +++ b/094/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "094", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 67, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/094/surgery_description.txt b/094/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5aec326c8820e1368eea5890eb96b8a02ff3dc39 --- /dev/null +++ b/094/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy with Partial pharyngectomy, Neck dissection diff --git a/094/surgery_report.txt b/094/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..37cd2be1b870fc8feef264cd29d226a1aaa0a14e --- /dev/null +++ b/094/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and preparation of the patient by the anesthesia colleagues, the patient is first positioned. Entry with the small bore tube under dental protection to inspect the primary tumor region. The base of the tongue, vallecula and epiglottis are clear. The tumorous mass begins in the area of the aryepiglottic fold on the left, extends to the ary, infiltrates it and moves over the pocket fold to the left vocal fold, extends there to the anterior commissure, growth over the medial wall of the piriform sinus to the anterior wall here and tumorous fixation of the piriform sinus to the hemilarynx. The lateral wall of the piriform sinus, the posterior wall of the hypopharynx and the entire right side are tumor-free, as are the postcricoid region and the esophageal entrance. Insertion of a nasogastric tube under visualization. Repositioning of the patient and injection of xylocaine with added adrenaline. Skin incision to perform an apron flap. Cutting through skin and subcutaneous tissue. Exposure and dissection of the platysma. High dissection of the platysma and high suture of the apron flap. Exposure of the sternocleidomastoid muscle on both sides and preservation of the external jugular vein. Exposure of the omohyoid muscle, exposure of the submandibular gland and the digastric muscle on both sides. Exposure and free preparation of the hyoid. Subsequent dissection of the infrahyoid musculature from the hyoid. Skeletonization of the larynx. Exposure of the thyroid cartilage horns. On the left side, the tumor can already be palpated endolaryngeally in this area and therefore a tissue sleeve is left here. Complete skeletonization on the right side. Release of the piriform sinus. Exposure of the cricoid cartilage. Separation of the thyroid isthmus. Exposure of the anterior surface of the trachea. Laryngoscopy showed no evidence of subglottic expansion, therefore tracheotomy was performed between the 1st and 2nd tracheal ring and later intubation was changed to an LE tube. With the vallecula and epiglottis free, the tube is now inserted below the hyoid and centrally into the vallecula, followed by the epiglottis. Resection along the right aryepiglottic folds and thus extension of the pharyngotomy. Now a good overview of the tumor. This is as described above. Triggering of the right piriform sinus. Resection postcricoid. Here on the left side of the postcricoid ary widening of the safety margin with superficial whitish changes. Partial resection of the left piriform sinus while maintaining a safety distance of approx. 1.5 cm from the tumor here. Safe in sano conditions on all sides towards the depth with overlying soft tissue mantle. After resection of the tumor, preparation strictly close to the cartilage. Release the esophagus and place the larynx at the level of the tracheotomy. Careful inspection. ............... A somewhat narrow area can be seen in the area of the pharyngeal side wall, otherwise wide on the right side. No extension towards the subglottic area. A post-resection is now performed in the area of the scarce deposit in the area of the pharyngeal side wall, which generously covers the described part. Subsequently, left-sided and postcricoid specimens are taken from the margins, completely mapping the tumor. These were found to be free of tumor and dysplasia in the frozen section diagnosis. Therefore, the overall situation here is R0. The neck dissections are now performed. Start with the right side. This shows a markedly strong jugular vein.... ........ or a divided internal jugular vein. A strong portion lies in front of the omohyoid muscle. Dissection of the vein. It can be seen that the very, very strong vein rejoins the internal jugular vein below the omohyoid muscle and also flows back into it cranially. Leave the vascular variation. Free preparation of the veins. Clearing of level V a with careful protection of the cervical plexus branches. Here several nodes are not necessarily macroscopically suspicious. Exposure of the accessorius nerve. Release of the accessorius triangle with careful protection of the nerve. Clearing of the anterior neck preparation with exposure of the common carotid artery, preservation of the superior thyroid artery and the hypoglossal nerve. Overall, there were no compelling suspicious nodules. Careful wound inspection and turning to the opposite side if the wound is dry. A clinically clear metastasis measuring approx. 5 cm is seen at the transition from level III to IV. Caudal dissection of the internal jugular vein. Clearing of the anterior neck preparation while preserving the superior thyroid artery and the hypoglossal nerve. The metastasis extends medially to the common carotid artery and prevertebral fascia, but can be easily detached without any signs of infiltration and regular release of the hypoglossal nerve. Careful dissection of the internal jugular vein. Here it is noticeable that an area of approx. 2 cm is clearly infiltrated at the free edge and therefore caudal separation of the internal jugular vein. Laterally, there is no clear infiltration of the sternocleidomastoid muscle, but there is clear adherence here. Therefore, a muscle cuff is taken and left on the node. Take level V a with careful protection of the caudal lymph vessels. Caudal ligation when moving towards level V b. Before removing the vein, secure and follow the vagus nerve. This is safely free. Cranially, the accessorius nerve can be exposed and preserved. Clear the accessorius triangle with careful protection. Leave the inflow of the facial vein caudally and remove the anterior jugular vein cranial to the metastasis and remove the neck preparation. The cervical plexus was also preserved. Careful wound inspection and, if the wound was dry, insertion of an 8 mm Provox prosthesis. Placement in the usual manner using the pull-through method at the cranial edge of the tracheal insertion margin. The paramedian myotomy in the area of the upper esophageal sphincter had already been performed previously. This results in wide ratios. Later, the sternal insertions of the sternocleidomastoid muscle are also removed. Subsequently, if the mucosal conditions are strong and sufficient, the initially submucosal, inverting mucosal suture is used to close the pharynx. Overall two-layer closure. Subsequent readaptation of the released infrahyoid muscles to the hyoid. Subsequent final wound inspection and, if conditions are dry and the wound is irrigated, insertion of 2 10-gauge Redon drains and careful, two-layer wound closure with circular suturing of the tracheostoma without increased tension. The patient was given intraoperative intravenous antibiotics with Unacid 3 g. This should be continued for 24 hours postoperatively. Please continue this for 24 hours postoperatively. Conclusion: Intraoperative R0 resected cT3 cN2a supraglottic laryngeal carcinoma on the left. With clinically normal wound healing, postoperative X-ray gruel swallow on the 10th postoperative day please. Presentation at our interdisciplinary tumor conference for adjuvant therapy, which will certainly be necessary. \ No newline at end of file diff --git a/095/InvasionFront_CD3_block12_x3_y3_patient095_0.json b/095/InvasionFront_CD3_block12_x3_y3_patient095_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d7d9263619c8bcdf21cf2c9ae3d483333da874f7 --- /dev/null +++ b/095/InvasionFront_CD3_block12_x3_y3_patient095_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11968.7, + "Centroid Y µm": 12143.6, + "Num Detections": 20934, + "Num Negative": 19497, + "Num Positive": 1437, + "Positive %": 6.864, + "Num Positive per mm^2": 580.08 + } +} \ No newline at end of file diff --git a/095/InvasionFront_CD3_block12_x4_y3_patient095_1.json b/095/InvasionFront_CD3_block12_x4_y3_patient095_1.json new file mode 100644 index 0000000000000000000000000000000000000000..da294942383727795c71a322ffcb98babca0ae3e --- /dev/null +++ b/095/InvasionFront_CD3_block12_x4_y3_patient095_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14692.2, + "Centroid Y µm": 12393.4, + "Num Detections": 23391, + "Num Negative": 19705, + "Num Positive": 3686, + "Positive %": 15.76, + "Num Positive per mm^2": 1506.6 + } +} \ No newline at end of file diff --git a/095/InvasionFront_CD8_block12_x3_y3_patient095_0.json b/095/InvasionFront_CD8_block12_x3_y3_patient095_0.json new file mode 100644 index 0000000000000000000000000000000000000000..37607b52e05e909590a22e275c10a64ef5f29809 --- /dev/null +++ b/095/InvasionFront_CD8_block12_x3_y3_patient095_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11743.8, + "Centroid Y µm": 11069.1, + "Num Detections": 21807, + "Num Negative": 19428, + "Num Positive": 2379, + "Positive %": 10.91, + "Num Positive per mm^2": 949.46 + } +} \ No newline at end of file diff --git a/095/InvasionFront_CD8_block12_x4_y3_patient095_1.json b/095/InvasionFront_CD8_block12_x4_y3_patient095_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e166fb8d6d3093958a9cb0fdd11c8c74bc1120ee --- /dev/null +++ b/095/InvasionFront_CD8_block12_x4_y3_patient095_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14417.4, + "Centroid Y µm": 10994.2, + "Num Detections": 23341, + "Num Negative": 19346, + "Num Positive": 3995, + "Positive %": 17.12, + "Num Positive per mm^2": 1608.1 + } +} \ No newline at end of file diff --git a/095/TumorCenter_CD3_block12_x3_y3_patient095_0.json b/095/TumorCenter_CD3_block12_x3_y3_patient095_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a17775bf6460b89973f6e759e581c9116afa47c1 --- /dev/null +++ b/095/TumorCenter_CD3_block12_x3_y3_patient095_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10869.2, + "Centroid Y µm": 7471.0, + "Num Detections": 24581, + "Num Negative": 22818, + "Num Positive": 1763, + "Positive %": 7.172, + "Num Positive per mm^2": 723.32 + } +} \ No newline at end of file diff --git a/095/TumorCenter_CD3_block12_x4_y3_patient095_1.json b/095/TumorCenter_CD3_block12_x4_y3_patient095_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e8cd4cbfa09bef3c7c433c288f37162671325dee --- /dev/null +++ b/095/TumorCenter_CD3_block12_x4_y3_patient095_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 7371.1, + "Num Detections": 22153, + "Num Negative": 20699, + "Num Positive": 1454, + "Positive %": 6.563, + "Num Positive per mm^2": 635.56 + } +} \ No newline at end of file diff --git a/095/TumorCenter_CD8_block12_x3_y3_patient095_0.json b/095/TumorCenter_CD8_block12_x3_y3_patient095_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a8389f684d470bfc103282766616a7358ae2eff0 --- /dev/null +++ b/095/TumorCenter_CD8_block12_x3_y3_patient095_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14383.0, + "Centroid Y µm": 16836.7, + "Num Detections": 21403, + "Num Negative": 20034, + "Num Positive": 1369, + "Positive %": 6.396, + "Num Positive per mm^2": 564.4 + } +} \ No newline at end of file diff --git a/095/TumorCenter_CD8_block12_x4_y3_patient095_1.json b/095/TumorCenter_CD8_block12_x4_y3_patient095_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f19ac43d5a4a47034c3716977127dc21bb67a39 --- /dev/null +++ b/095/TumorCenter_CD8_block12_x4_y3_patient095_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17059.2, + "Centroid Y µm": 16834.4, + "Num Detections": 19388, + "Num Negative": 18177, + "Num Positive": 1211, + "Positive %": 6.246, + "Num Positive per mm^2": 547.22 + } +} \ No newline at end of file diff --git a/095/history_text.txt b/095/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/095/icd_codes.txt b/095/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2d7fc84bff07d6547fc3da21162d2d8a30244a4e --- /dev/null +++ b/095/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, nicht näher bezeichnet[C09.9 ] \ No newline at end of file diff --git a/095/ops_codes.txt b/095/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..809b89b1dd8e438d102ee3fb5099c84637dd2e9e --- /dev/null +++ b/095/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie (ohne Adenotomie): Radikal, transoral[5-281.2 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/095/patient_clinical_data.json b/095/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..172bcb4f915ed9f210bf2b2450c5ab77e05b4f99 --- /dev/null +++ b/095/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/095/patient_pathological_data.json b/095/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7521eac44b38d21586c2029c7da1038babe6e533 --- /dev/null +++ b/095/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "095", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/095/surgery_description.txt b/095/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d0deba8b4590620259967a3543ea02a9ceed6d1 --- /dev/null +++ b/095/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, PEG, Enoral tumor resection, Bilateral neck dissection diff --git a/095/surgery_report.txt b/095/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6b0619ef63876388c366f05ec930d6687a493fbd --- /dev/null +++ b/095/surgery_report.txt @@ -0,0 +1 @@ +Oesophagoscopy and PEG insertion: Easy entry into the stomach with the oesophagoscope. Inconspicuous mucosal conditions can be seen here. Inversion without any problems. After safe diaphanoscopy, PEG placement is performed in the typical manner using the thread pull-through method. Pharyngoscopy and laryngoscopy: The well-known tumor measuring approx. 2 x 3 cm can be seen in the area of the tonsil on the left side. On the right side in the area of the uvula as well as the posterior pharyngeal wall, the piriform sinus on both sides, the esophageal entrance and the entire endolarynx, the mucosal conditions are unremarkable. No evidence of exophytic tumor growth. Enoral tumor resection: insertion of the Mc Ivor blade. Establish the resection margins with sufficient safety distance using the electric needle. Successive release of the tumor under visual control. Careful hemostasis with the bipolar. The resection covers the entire tonsil on the left side and extends into the base of the tongue and onto the posterior pharyngeal wall. The preparation is then marked with a suture and sent for a frozen section. Insertion of two hydrogen compresses and repositioning for neck dissection on the right side. Skin disinfection and local anesthesia. Approx. 15 cm long curved skin incision in the area of the front edge of the sternocleidomastoid muscle. Separation of the subcutaneous tissue. Separation of the platysma. Exposure of the anterior edge of the sternocleidomastoid muscle. Dissection of the medial part of the muscle. Exposure of the digastricus venter posterior muscle and the omohyoid muscle. Then expose the accessorius nerve and the internal jugular vein. The internal jugular vein is now successively exposed. Then explore the anterior galenic muscle in the caudal region. Now successively dissect the neck preparation caudally with careful bipolar coagulation. Then dissect and clear the accessorius triangle. Release the lateral neck preparation from cranial to caudal while protecting the plexus branches. Then careful hemostasis with the bipolar. Now dissect the facial vein and the submandibular gland. Then evacuation of the venous angle with exposure of the hypoglossal nerve. The capsule of the submandibular gland is also removed in the caudal part. Finally, the caudal part of the medial neck preparation is removed. This allows the cervical anus to be spared. Then rinse with hydrogen and Ringer's solution. Careful hemostasis. Insertion of a 10 mm Redon drain. Cutaneous suture. Skin suture. After obtaining the frozen section, the patient is repositioned again. The frozen section shows a carcinoma in situ in the area of the median margin. The decision is therefore made to resect. The electric needle is now used to carefully resect again. Subsequent careful hemostasis. Insertion of two hydrogen swabs. The specimen is sent for final histology. Finally, no cervical structures are exposed in the area of the oral cavity. Now repositioning for neck dissection on the left side: skin disinfection. Local anesthesia. Renewed, approx. 15 cm long curved skin incision in the area of the front edge of the sternocleidomastoid muscle. Cut through the subcutaneous tissue and the platysma. Exposure of the anterior edge of the sternocleidomastoid muscle and exposure of the muscle in its median portion. Exposure of the omohyoid muscle and the posterior digastric muscle. An extensive, firmly attached lymph node bundle is now visible in the area of level II, which appears to be directly adjacent to the accessorius nerve and the internal jugular vein. The accessorius nerve is shown in its caudal course. The internal jugular vein is also dissected in its caudal course. The anterior scalene muscle is now explored in the caudal region. The internal jugular vein is now dissected from caudal to cranial. The neck preparation is then placed in the caudal region. This is done with careful bipolar coagulation. The thoracic duct is not exposed. The facial vein is then exposed in the cranial region and the venous angle is dissected. The hypoglossal nerve is successfully exposed. Then, with great difficulty, the lymph node conglomerate is detached from the internal jugular vein and the venous angle is dissected. The accessorius nerve is now dissected further cranially. This results in the opening of an apparently necrotic, disintegrating lymph node. The escaping fluid is suctioned out with the aspirator. The lymph node conglomerate is then removed while sparing the accessorius nerve. Now there is a much better overview. The entire course of the accessory nerve can now be visualized. The accessorius triangle is then evacuated. This is done with careful hemostasis. Further suspicious lymph nodes are also clinically present here. These are now successively removed. Expose the internal jugular vein in its entire course from caudal to cranial. Subsequently, successive dissection of the lateral neck preparation and removal of the same with careful hemostasis. Due to the adhesions in the cranial area, some smaller branches of the cervical plexus are also resected. The cervical plexus itself can be preserved. The caudal medial neck preparation is then removed while sparing the cervical nerve. In addition, removal of the caudal part of the capsule of the submandibular gland. Careful hemostasis and irrigation with hydrogen and Ringer's solution. Insertion of a 10-gauge Redon drain. Subcutaneous suture. Skin suture. Now reposition again for endoral inspection: the inserted hydrogen swabs are now removed. Careful hemostasis again with the bipolar. The operation is then completed without bleeding or complications. Conclusion: Enormous tumor resection of a T2 tonsillar carcinoma on the left. First CIS in the median part in the frozen section, therefore decision to resect. Problem-free PEG placement. Neck dissection on both sides, levels 1b to 5, with clinically suspicious lymph nodes on the left side in levels 1b, 2 and 3. \ No newline at end of file diff --git a/096/InvasionFront_CD3_block16_x5_y9_patient096_0.json b/096/InvasionFront_CD3_block16_x5_y9_patient096_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d5d54ae87f84ad4fda83d674b9f81aff41f07aed --- /dev/null +++ b/096/InvasionFront_CD3_block16_x5_y9_patient096_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16698.5, + "Centroid Y µm": 26957.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/096/InvasionFront_CD3_block16_x6_y9_patient096_1.json b/096/InvasionFront_CD3_block16_x6_y9_patient096_1.json new file mode 100644 index 0000000000000000000000000000000000000000..810fda767f92d0c2cd5ac46b35fdf2b805b0aeac --- /dev/null +++ b/096/InvasionFront_CD3_block16_x6_y9_patient096_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19169.3, + "Centroid Y µm": 27005.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/096/InvasionFront_CD8_block16_x5_y9_patient096_0.json b/096/InvasionFront_CD8_block16_x5_y9_patient096_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4891fd037e5b8de75d38af848a5f86ad30adee94 --- /dev/null +++ b/096/InvasionFront_CD8_block16_x5_y9_patient096_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 22358.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/096/InvasionFront_CD8_block16_x6_y9_patient096_1.json b/096/InvasionFront_CD8_block16_x6_y9_patient096_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bb270a68002367dd5ee68aa80da2443294e4a81f --- /dev/null +++ b/096/InvasionFront_CD8_block16_x6_y9_patient096_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 22358.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/096/TumorCenter_CD3_block16_x5_y9_patient096_0.json b/096/TumorCenter_CD3_block16_x5_y9_patient096_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bf33b3df2d68394f127fbd7a591e53156e18a250 --- /dev/null +++ b/096/TumorCenter_CD3_block16_x5_y9_patient096_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 23237.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/096/TumorCenter_CD3_block16_x6_y9_patient096_1.json b/096/TumorCenter_CD3_block16_x6_y9_patient096_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1d8c2ce78cc75851af791fa51f9ca05768de0af3 --- /dev/null +++ b/096/TumorCenter_CD3_block16_x6_y9_patient096_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 23362.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/096/TumorCenter_CD8_block16_x5_y9_patient096_0.json b/096/TumorCenter_CD8_block16_x5_y9_patient096_0.json new file mode 100644 index 0000000000000000000000000000000000000000..83ee98a42fd41fcc4a16261fb78ffd8aac2c45f0 --- /dev/null +++ b/096/TumorCenter_CD8_block16_x5_y9_patient096_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 23037.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/096/TumorCenter_CD8_block16_x6_y9_patient096_1.json b/096/TumorCenter_CD8_block16_x6_y9_patient096_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6191de336dac03556b49a02083e855f33b67ec08 --- /dev/null +++ b/096/TumorCenter_CD8_block16_x6_y9_patient096_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 23062.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/096/history_text.txt b/096/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/096/icd_codes.txt b/096/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/096/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/096/ops_codes.txt b/096/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1367f1fbbfa944f7b461abbe0cef461dc45fd5ec --- /dev/null +++ b/096/ops_codes.txt @@ -0,0 +1 @@ +Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Exzision[5-250.2 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 R] Resektion einer Speicheldrüse: Parotidektomie, partiell: Mit intraoperativem Fazialismonitoring[5-262.01 R] \ No newline at end of file diff --git a/096/patient_clinical_data.json b/096/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..938b30e7132f6af70bdfc9c571caf9560a514115 --- /dev/null +++ b/096/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/096/patient_pathological_data.json b/096/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b33f3a32b70210a92c95f7ddde4c4a0d43990744 --- /dev/null +++ b/096/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "096", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 21, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/096/surgery_description.txt b/096/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..545d97764a941d47334311034ed52936b3152c40 --- /dev/null +++ b/096/surgery_description.txt @@ -0,0 +1 @@ +Right tonsillectomy, Resection of right tongue margin carcinoma, PEG, Partial parotidectomy, Modified radical right neck dissection diff --git a/096/surgery_report.txt b/096/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a66549bfe784c9717c0368c6ec7df376bb51979 --- /dev/null +++ b/096/surgery_report.txt @@ -0,0 +1 @@ +Start with pharyngoscopy: inspection of the oral cavity, buccal mucosa and oropharynx. A spherical mass can be seen in the area of the right edge of the tongue at the transition from the edge of the tongue to the base of the tongue opposite the alveolar ridge. A causative tooth-related alteration cannot be detected, which is why this site is highly suspicious for malignancy, corresponding to the illumination in the PET-CT. The right tonsil was also conspicuous on PET-CT. Tonsillectomy started on the right side: Incision at the upper tonsil pole. Blunt, partly sharp release of the tonsil from its bed. Repeated bipolar coagulation underneath. At the end here wound surfaces free of bleeding after extirpation of the tonsil at the lower pole, after removal with the bipolar in toto. Then insertion of the reinforced retractor. Insertion of a Mersilene into the tip of the tongue, fluxing out and then consecutively, with bipolar coagulation and scissors, 1 cm in the healthy tissue, removal of the suspected carcinoma. This is then confirmed and identified as a carcinoma by telephone frozen section. Resection status in the frozen section R0. Low to moderate grade dysplasia is diagnosed in the tonsil, there is no carcinoma growth. Now advancement of the size C small bore tube into the hypopharynx/larynx. Inconspicuous conditions everywhere. Now insertion of the flexible esophagogastroscope, advancement into the esophagus. A fibrin-covered, superficial erosion can be seen 35 cm aborally, which most likely corresponds to an inflammatory change. Please perform a control gastroscopy in internal medicine! Pre-mirroring into the stomach. After skin disinfection and infiltration anesthesia, a percutaneous endoscopic gastrostomy tube 9 Charričre can now be placed. This is done under strict diaphanoscopic control and works well. Fix the holding plate with adequate pressure. Sterile dressing. Now repositioning for parotid surgery and neck dissection. Application of neuromonitoring, skin disinfection, infiltration anesthesia. Opening of the old skin scar in the area of the parotid ligament. Dissection of a ventral pedicled flap after spindle-shaped excision of the previously made skin incision. The macroscopic tumor described above can be seen here. First expose the anterior margin of the sternocleidomastoid. Dissect cranially up to the lobule. Careful release of the laterocaudal part of the gland. Then dissect the cartilaginous auditory canal in depth. Exposure of the pointer. Then expose the facial nerve trunk. This is now followed in its cervicofacial portion into the periphery. The cervical branch cannot be preserved, but the marginal ramus can. Then complete detachment of the caudal parotid pole in toto. The cranial resection margins are macroscopically unremarkable. The complete parotid pole is then removed, taking the digastric muscle with it in toto. Identification of the hypoglossal nerve and the accessorius nerve. However, it can be seen that the hypoglossal nerve runs through the metastasis, as well as the vagus nerve in its cranial part through the tumor and the accessorius. First widening of the skin incision. Exposure of the anterior margin of the sternocleidomastoid at the lower part. Exposure of the small venous angle. Exposure of the omohyoid and dissection along the digastric muscle ventrally. The metastasis is located in level V or II. After creating clear conditions, demonstration of the findings on . The infiltrated auditory nerves cannot be preserved, nor can the internal jugular vein. Double ligation and removal of the internal jugular vein, removal of the vagus nerve, the hypoglossal nerve and the accessory nerve. Complete removal of the metastasis in toto. Parts of the sternocleidomastoid muscle are also removed in the accessorius triangle. In this way it is possible to remove the metastasis in toto while leaving microscopically inconspicuous tissue parts. Dissection of the vessel.......... upwards. Exposure of the internal carotid artery, external carotid artery and internal jugular artery far below the omohyoid muscle. At the base of the skull before removal of the internal jugular vein as part of the tumor conglomerate ligation and repositioning. This results in a neck dissection from level I b to V. At the end, ensure hemorrhage-free conditions. Stimulation of the facial nerve and the dissected branches with 0.5 mA. Irrigation with Ringer's solution. Placement of a Redon drain and two-layer wound closure and pressure dressing. Conclusion: Tongue margin carcinoma cT1 cN2b. Modified radical neck dissection with resection of the vagus nerve, hypoglossus, accessorius. Please perform postoperative gastroscopy as described above. Wound irrigation with Betaisadona solution for 1 week. Tonsillectomy diet from the 3rd to 5th day. Ensure adequate analgesia. Cervical suture removal on the 7th postoperative day. \ No newline at end of file diff --git a/097/InvasionFront_CD3_block22_x1_y8_patient097_0.json b/097/InvasionFront_CD3_block22_x1_y8_patient097_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dbc107266f4cf55de38fae40034b6f0b778e9eb6 --- /dev/null +++ b/097/InvasionFront_CD3_block22_x1_y8_patient097_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4422.7, + "Centroid Y µm": 31833.1, + "Num Detections": 17259, + "Num Negative": 16431, + "Num Positive": 828, + "Positive %": 4.797, + "Num Positive per mm^2": 436.36 + } +} \ No newline at end of file diff --git a/097/InvasionFront_CD3_block22_x2_y8_patient097_1.json b/097/InvasionFront_CD3_block22_x2_y8_patient097_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e958788253dba188f820a700e87d28c1eb992d5f --- /dev/null +++ b/097/InvasionFront_CD3_block22_x2_y8_patient097_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 31508.3, + "Num Detections": 11755, + "Num Negative": 10935, + "Num Positive": 820, + "Positive %": 6.976, + "Num Positive per mm^2": 552.9 + } +} \ No newline at end of file diff --git a/097/InvasionFront_CD8_block22_x1_y8_patient097_0.json b/097/InvasionFront_CD8_block22_x1_y8_patient097_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3a56e62ecfe3bd4be0d663c9162dd9ab4422cf66 --- /dev/null +++ b/097/InvasionFront_CD8_block22_x1_y8_patient097_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7107.1, + "Centroid Y µm": 20386.2, + "Num Detections": 15943, + "Num Negative": 15103, + "Num Positive": 840, + "Positive %": 5.269, + "Num Positive per mm^2": 487.69 + } +} \ No newline at end of file diff --git a/097/InvasionFront_CD8_block22_x2_y8_patient097_1.json b/097/InvasionFront_CD8_block22_x2_y8_patient097_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e60a466d0b336e5415d518e40b2d244133eed83 --- /dev/null +++ b/097/InvasionFront_CD8_block22_x2_y8_patient097_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9359.0, + "Centroid Y µm": 19831.1, + "Num Detections": 11359, + "Num Negative": 10643, + "Num Positive": 716, + "Positive %": 6.303, + "Num Positive per mm^2": 518.84 + } +} \ No newline at end of file diff --git a/097/TumorCenter_CD3_block22_x1_y8_patient097_0.json b/097/TumorCenter_CD3_block22_x1_y8_patient097_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6969d50fffc342fe665bf518ef2283299f0481d4 --- /dev/null +++ b/097/TumorCenter_CD3_block22_x1_y8_patient097_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4272.7, + "Centroid Y µm": 20139.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/097/TumorCenter_CD3_block22_x2_y8_patient097_1.json b/097/TumorCenter_CD3_block22_x2_y8_patient097_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0c07965901272b9ce23a4c6ebb2c4bea094890e2 --- /dev/null +++ b/097/TumorCenter_CD3_block22_x2_y8_patient097_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6971.3, + "Centroid Y µm": 20239.3, + "Num Detections": 16348, + "Num Negative": 15326, + "Num Positive": 1022, + "Positive %": 6.252, + "Num Positive per mm^2": 503.6 + } +} \ No newline at end of file diff --git a/097/TumorCenter_CD8_block22_x1_y8_patient097_0.json b/097/TumorCenter_CD8_block22_x1_y8_patient097_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3bc6a423123ceb76b4f5ece18092d0acea1457f8 --- /dev/null +++ b/097/TumorCenter_CD8_block22_x1_y8_patient097_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 29759.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/097/TumorCenter_CD8_block22_x2_y8_patient097_1.json b/097/TumorCenter_CD8_block22_x2_y8_patient097_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dc6fc5bbf9dd3efcd6b60097ade187985d8ec201 --- /dev/null +++ b/097/TumorCenter_CD8_block22_x2_y8_patient097_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8945.3, + "Centroid Y µm": 29884.2, + "Num Detections": 17077, + "Num Negative": 15456, + "Num Positive": 1621, + "Positive %": 9.492, + "Num Positive per mm^2": 754.26 + } +} \ No newline at end of file diff --git a/097/history_text.txt b/097/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5bf1855ae129fb6457f77e2d2dc0011ec4731b09 --- /dev/null +++ b/097/history_text.txt @@ -0,0 +1 @@ +He has a histologically confirmed G2 squamous cell carcinoma of the larynx (cT4 cN1) on the right side. The findings were confirmed by panendoscopy <2016> in domo. A CT scan of the neck and thorax with contrast medium performed by us showed no evidence of thyroid cartilage infiltration. Secondary findings included a contrast-absorbing lesion in the area of the right vallecula and in the area of the right glossotonsillar groove. Based on the findings, the above-mentioned operation was indicated. The patient was informed in detail about the procedure and had sufficient time to ask questions. He was also presented to our phoniatrics department and had a discussion with the laryngectomy association. \ No newline at end of file diff --git a/097/icd_codes.txt b/097/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..052a14170998e2e80dca93c824b7e71944b0428c --- /dev/null +++ b/097/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 R] \ No newline at end of file diff --git a/097/ops_codes.txt b/097/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b88be70d94bc42dffc20748e10ca50f659668317 --- /dev/null +++ b/097/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Permanente Tracheotomie[5-312.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Biopsie an den Tonsillen ohne Inzision[1-422.01 R] Biopsie ohne Inzision Oropharynx sonstige[1-422.0x R] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Ösophagomyotomie sonstige[5-420.0x ] \ No newline at end of file diff --git a/097/patient_clinical_data.json b/097/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4d210ec858e4b82809bedfdee06e801c12df89b8 --- /dev/null +++ b/097/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/097/patient_pathological_data.json b/097/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..476bb59740e6b563966663685553e154476cc766 --- /dev/null +++ b/097/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "097", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/097/surgery_description.txt b/097/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c94cec136d7543b4d107484fa22dabfb9b337cfb --- /dev/null +++ b/097/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Provox prosthesis, PEG placement, Panendoscopy diff --git a/097/surgery_report.txt b/097/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..16697533198966ab214b6c9ad07e26b6655c145f --- /dev/null +++ b/097/surgery_report.txt @@ -0,0 +1 @@ +Transferring the patient to the operating theater . Patient identification. Carrying out the team time-out in the usual manner. Induction of intubation anesthesia by the anesthesia colleagues. Start of the operation with panendoscopy. Inspection of the endolarynx: a transglottic laryngeal carcinoma is found in the area of the right pocket fold and supraglottic, growing to approx. 2 cm subglottically. The tumor dominates on the right side, extending over the anterior commissure to half of the left vocal fold. Retraction of the small siphon tube and inspection of the lesions described in the CT scan in the area of the right vallecula. This shows a ruptured vallecula cyst. To rule out malignancy, samples are taken and sent for frozen section diagnostics (frozen section not malignant). Inspection of the right glossotonsillar groove: if the mucosa is normal, superficial PEs are also taken to rule out malignancy (frozen section, also non-malignant). Insertion of a nasogastric tube. Removal of the small esophageal tube and insertion of the flexible gastroesophagoscope into the esophagus and careful advancement into the stomach. Check the stomach again. The mucosa is found to be free of irritation on all sides. Insertion of a PEG tube in the usual manner using the thread pull-through method without complications. The patient is then repositioned in a head down position. Injection of xylocaine with the addition of suprarenin. Sterile abjodation and draping of the patient. Start with the tracheotomy: skin incision below the cricoid cartilage. Separation of the subcutaneous tissue. Separation of the platysma. Identification of the superficial neck muscles and incision in the midline. Lateralization of the neck muscles with the retractors. Identification of the thyroid isthmus. Undermining of the isthmus with the clamp and transection of the isthmus after bipolar coagulation. Identification of the anterior wall of the trachea. Freeing the trachea from the surrounding tissue. Due to the previously described subglottic extension of the tumor, the tracheotomy is performed deep (between the 4th and 5th tracheal cartilage). Suturing at the caudal wound edge and insertion of an LE tube. Continuation of the operation with incision of the apron flap. Separation of the skin, subcutis and platysma. Subplatysmal dissection up to the exposure of the hyoid bone and the submandibular gland on both sides. Opening of the glandular capsule and detachment of the submandibular gland from the glandular bed on both sides. Identification of the anterior border of the sternocleidomastoid muscle on the right side to perform the neck dissection. Neck dissection on the right by : After identification of the sternocleidomastoid muscle, dissection down to the deep cervical fascia. In doing so, protect the plexus branches of the cervical plexus. Exposure of the accessorius nerve and free dissection. The nerve can be safely spared. Identification of the posterior venter of the digastric muscle. Identification of the omohyoid muscle and tracing of the muscle to the hyoid bone. Dissect the internal jugular vein while safely identifying and protecting the common carotid artery and the vagus nerve. Now detach the neck preparation from region II to IV from cranial to caudal from the deep cervical fascia while protecting the plexus branches. Minor bleeding is coagulated bipolarly. Neck dissection on the right side is successful without any problems. The same procedure is now performed on the left side by . Overall, there are no macroscopically clearly suspicious lymph nodes, although the lymph nodes are clearly enlarged and enlarged on both sides. Free preparation of the hyoid bone by loosening the supra- and infrahyoid muscles. On the left side, the infrahyoid musculature is completely folded caudally. On the right side, it is cut in the midline in order to avoid dissecting into the tumor as much as possible. Removal of the hyoid bone. Release the oblique laryngeal muscles on the right and left side with careful dissection. This can be done without any problems and without any evidence of soft tissue infiltration. Now release the upper edge of the thyroid cartilage. Careful dissection of the piriform sinus from the thyroid cartilage on both sides. Enter the pharynx on the left side. Then disluxation of the epiglottis and incision of the mucosa at the edge of the epiglottis to behind the arytenoid region on both sides. Subsequent removal of the larynx below the cricoid cartilage. Removal of the larynx and collection of several representative marginal samples by . After removal of the larynx, a Provox prosthesis is placed in the usual manner. In addition, a myotomy of the esophageal inlet is performed. The two-layer pharyngeal closure is performed in the usual manner. In addition, as much preserved muscle as possible is placed over the suture in a 3rd step. Retraction of the apron flap Incision of the tracheostoma and two-layer wound closure using subcutaneous and cutaneous sutures. Application of a wrap bandage. Please continue antibiotics for at least 24 hours. Nutrition via the PEG tube. The dressing must be changed daily and should be left in place for a total of 1 week. X-ray gruel on the 12th to 14th postoperative day. \ No newline at end of file diff --git a/098/InvasionFront_CD3_block16_x1_y10_patient098_0.json b/098/InvasionFront_CD3_block16_x1_y10_patient098_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bc970d65a10e0d659620c1315ca02443b0016d55 --- /dev/null +++ b/098/InvasionFront_CD3_block16_x1_y10_patient098_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4397.0, + "Centroid Y µm": 29146.4, + "Num Detections": 13037, + "Num Negative": 12626, + "Num Positive": 411, + "Positive %": 3.153, + "Num Positive per mm^2": 207.56 + } +} \ No newline at end of file diff --git a/098/InvasionFront_CD3_block16_x2_y10_patient098_1.json b/098/InvasionFront_CD3_block16_x2_y10_patient098_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3a1570465e64abae21b8cf613c7bf67cbe826449 --- /dev/null +++ b/098/InvasionFront_CD3_block16_x2_y10_patient098_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7063.8, + "Centroid Y µm": 29340.2, + "Num Detections": 15546, + "Num Negative": 14761, + "Num Positive": 785, + "Positive %": 5.05, + "Num Positive per mm^2": 379.23 + } +} \ No newline at end of file diff --git a/098/InvasionFront_CD8_block16_x1_y10_patient098_0.json b/098/InvasionFront_CD8_block16_x1_y10_patient098_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3d7316c12b1695ef0f6603d0f9710eadbd8535e6 --- /dev/null +++ b/098/InvasionFront_CD8_block16_x1_y10_patient098_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3322.4, + "Centroid Y µm": 24284.2, + "Num Detections": 9239, + "Num Negative": 8538, + "Num Positive": 701, + "Positive %": 7.587, + "Num Positive per mm^2": 580.87 + } +} \ No newline at end of file diff --git a/098/InvasionFront_CD8_block16_x2_y10_patient098_1.json b/098/InvasionFront_CD8_block16_x2_y10_patient098_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e75611400632655e03d00af857658027a9510be0 --- /dev/null +++ b/098/InvasionFront_CD8_block16_x2_y10_patient098_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5968.5, + "Centroid Y µm": 24314.5, + "Num Detections": 12268, + "Num Negative": 11340, + "Num Positive": 928, + "Positive %": 7.564, + "Num Positive per mm^2": 559.57 + } +} \ No newline at end of file diff --git a/098/TumorCenter_CD3_block16_x1_y10_patient098_0.json b/098/TumorCenter_CD3_block16_x1_y10_patient098_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14cf74a25c977564c6448b1da5a918c7c4adb805 --- /dev/null +++ b/098/TumorCenter_CD3_block16_x1_y10_patient098_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 25086.7, + "Num Detections": 10971, + "Num Negative": 10577, + "Num Positive": 394, + "Positive %": 3.591, + "Num Positive per mm^2": 211.09 + } +} \ No newline at end of file diff --git a/098/TumorCenter_CD3_block16_x2_y10_patient098_1.json b/098/TumorCenter_CD3_block16_x2_y10_patient098_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2ff396063ec8a2d234600f84588cc961714434f9 --- /dev/null +++ b/098/TumorCenter_CD3_block16_x2_y10_patient098_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 25211.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/098/TumorCenter_CD8_block16_x1_y10_patient098_0.json b/098/TumorCenter_CD8_block16_x1_y10_patient098_0.json new file mode 100644 index 0000000000000000000000000000000000000000..158ef860d4356353caddc66117324ca8232fc2a4 --- /dev/null +++ b/098/TumorCenter_CD8_block16_x1_y10_patient098_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 25236.6, + "Num Detections": 13405, + "Num Negative": 13010, + "Num Positive": 395, + "Positive %": 2.947, + "Num Positive per mm^2": 196.63 + } +} \ No newline at end of file diff --git a/098/TumorCenter_CD8_block16_x2_y10_patient098_1.json b/098/TumorCenter_CD8_block16_x2_y10_patient098_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c429abdf236f0ebdb48425f7b0737e5a251a94c0 --- /dev/null +++ b/098/TumorCenter_CD8_block16_x2_y10_patient098_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 25311.6, + "Num Detections": 14125, + "Num Negative": 13837, + "Num Positive": 288, + "Positive %": 2.039, + "Num Positive per mm^2": 156.62 + } +} \ No newline at end of file diff --git a/098/history_text.txt b/098/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2dc52d2f4e5bc9fb4d6ce0f0310ba9ad95b66ddd --- /dev/null +++ b/098/history_text.txt @@ -0,0 +1 @@ +The patient has an unclear tongue tumor on the right side of the tongue. Therefore, the above-mentioned procedure was performed. \ No newline at end of file diff --git a/098/icd_codes.txt b/098/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/098/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/098/ops_codes.txt b/098/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4284c6f18189f0758e4470f7376dbb9ee5b17bd8 --- /dev/null +++ b/098/ops_codes.txt @@ -0,0 +1 @@ +Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Inzision am Zungenrand[5-250.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] \ No newline at end of file diff --git a/098/patient_clinical_data.json b/098/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..aa02ee0569ff1f5167922938f7f96561efef5a15 --- /dev/null +++ b/098/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/098/patient_pathological_data.json b/098/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..aadb452df3c7fca5afbe250a8628d4f3e8a7919f --- /dev/null +++ b/098/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "098", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/098/surgery_description.txt b/098/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b12697a9fbf2d5d63d8365ff994142b56ee1bfb --- /dev/null +++ b/098/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection diff --git a/098/surgery_report.txt b/098/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..df4dc535403809751a96e6e913f70a850619d88c --- /dev/null +++ b/098/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia, tracheoscopy is performed first. Here, inconspicuous conditions in the entire area of the larynx as well as up to the bifurcation of the trachea. After intubation, perform microlaryngoendoscopy, hypopharyngoscopy and esophagogastroscopy. Mucosal conditions are also unremarkable here. Additional inspection of the oropharynx. Also unremarkable except for the papillomatous tumor on the right edge of the tongue with a size of approx. 1.5 cm in diameter. The tumor itself is soft to the touch, before resembling a papilloma. The tumor is then removed at the mucosal level, suture marking. Careful hemostasis. Repeated inspection. No bleeding. Termination of the procedure. \ No newline at end of file diff --git a/099/InvasionFront_CD3_block14_x5_y10_patient099_0.json b/099/InvasionFront_CD3_block14_x5_y10_patient099_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9ec1258b3ba905f731a49338ad24e616451d986f --- /dev/null +++ b/099/InvasionFront_CD3_block14_x5_y10_patient099_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16553.7, + "Centroid Y µm": 29097.1, + "Num Detections": 8170, + "Num Negative": 7366, + "Num Positive": 804, + "Positive %": 9.841, + "Num Positive per mm^2": 766.63 + } +} \ No newline at end of file diff --git a/099/InvasionFront_CD3_block14_x6_y10_patient099_1.json b/099/InvasionFront_CD3_block14_x6_y10_patient099_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6ddd5385aeeffad6e26a72af9bc5f2e8f1cb0af4 --- /dev/null +++ b/099/InvasionFront_CD3_block14_x6_y10_patient099_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19127.4, + "Centroid Y µm": 29259.5, + "Num Detections": 14845, + "Num Negative": 13816, + "Num Positive": 1029, + "Positive %": 6.932, + "Num Positive per mm^2": 625.43 + } +} \ No newline at end of file diff --git a/099/InvasionFront_CD8_block14_x5_y10_patient099_0.json b/099/InvasionFront_CD8_block14_x5_y10_patient099_0.json new file mode 100644 index 0000000000000000000000000000000000000000..19b0e4e0ae7928462075743f1a42cba791cd2608 --- /dev/null +++ b/099/InvasionFront_CD8_block14_x5_y10_patient099_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16641.2, + "Centroid Y µm": 24512.0, + "Num Detections": 16311, + "Num Negative": 14044, + "Num Positive": 2267, + "Positive %": 13.9, + "Num Positive per mm^2": 1044.4 + } +} \ No newline at end of file diff --git a/099/InvasionFront_CD8_block14_x6_y10_patient099_1.json b/099/InvasionFront_CD8_block14_x6_y10_patient099_1.json new file mode 100644 index 0000000000000000000000000000000000000000..45792742567901440b1b511387918ce7d54896f9 --- /dev/null +++ b/099/InvasionFront_CD8_block14_x6_y10_patient099_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19239.8, + "Centroid Y µm": 24661.9, + "Num Detections": 21581, + "Num Negative": 19468, + "Num Positive": 2113, + "Positive %": 9.791, + "Num Positive per mm^2": 882.79 + } +} \ No newline at end of file diff --git a/099/TumorCenter_CD3_block14_x5_y10_patient099_0.json b/099/TumorCenter_CD3_block14_x5_y10_patient099_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cd9119cf6bee24a656a56650ae2e42836bbfe5ad --- /dev/null +++ b/099/TumorCenter_CD3_block14_x5_y10_patient099_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 25586.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/099/TumorCenter_CD3_block14_x6_y10_patient099_1.json b/099/TumorCenter_CD3_block14_x6_y10_patient099_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cab948c524e4d563cd072f89b0a0b5050ec6b30b --- /dev/null +++ b/099/TumorCenter_CD3_block14_x6_y10_patient099_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18515.2, + "Centroid Y µm": 25711.4, + "Num Detections": 15428, + "Num Negative": 13925, + "Num Positive": 1503, + "Positive %": 9.742, + "Num Positive per mm^2": 738.77 + } +} \ No newline at end of file diff --git a/099/TumorCenter_CD8_block14_x5_y10_patient099_0.json b/099/TumorCenter_CD8_block14_x5_y10_patient099_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c6e0526be47eb1bbcaa9e3ddcb2654d7b16f9172 --- /dev/null +++ b/099/TumorCenter_CD8_block14_x5_y10_patient099_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15666.7, + "Centroid Y µm": 25561.5, + "Num Detections": 9011, + "Num Negative": 8459, + "Num Positive": 552, + "Positive %": 6.126, + "Num Positive per mm^2": 309.21 + } +} \ No newline at end of file diff --git a/099/TumorCenter_CD8_block14_x6_y10_patient099_1.json b/099/TumorCenter_CD8_block14_x6_y10_patient099_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c6083c3ca001713d74fd07c91c5aa4c0496b43ce --- /dev/null +++ b/099/TumorCenter_CD8_block14_x6_y10_patient099_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 25561.5, + "Num Detections": 14690, + "Num Negative": 13227, + "Num Positive": 1463, + "Positive %": 9.959, + "Num Positive per mm^2": 728.76 + } +} \ No newline at end of file diff --git a/099/history_text.txt b/099/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..be9b38e776840654d7ec14363837ae401785f44f --- /dev/null +++ b/099/history_text.txt @@ -0,0 +1 @@ +The patient has had a size-progressive mass on the left edge of her tongue for approx. 1 1/2 years, which has already been biopsied externally 3 times on an outpatient basis. In each case a papilloma with no evidence of malignancy. No other findings in the ENT area, no history of noxious substances, no preoperative CT neck/thorax, preoperative B-scan sonography cN0 neck status. Therefore indication for the above procedure. The patient had sufficient opportunity to ask questions about this preoperatively. \ No newline at end of file diff --git a/099/icd_codes.txt b/099/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0d1914d7b8297678ddf90da9ea809852883b67bb --- /dev/null +++ b/099/icd_codes.txt @@ -0,0 +1 @@ +Unsichere Neubildung der Zunge[D37.0 L] \ No newline at end of file diff --git a/099/ops_codes.txt b/099/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..61d68af9f42456eb9d3a78242ac9b7751f8b994e --- /dev/null +++ b/099/ops_codes.txt @@ -0,0 +1 @@ +Laserkoagulation Zungengewebe[5-250.31 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/099/patient_clinical_data.json b/099/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1bdf7130609db76e0fc418ac68688a8b7228d12e --- /dev/null +++ b/099/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 76, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/099/patient_pathological_data.json b/099/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..647096512edc3552fe66a0a46ed4972dddbbba8c --- /dev/null +++ b/099/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "099", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 20.0 +} \ No newline at end of file diff --git a/099/surgery_description.txt b/099/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ea292912c41f50115898d6be07c1cc75268e4fd0 --- /dev/null +++ b/099/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy of left tongue margin using diode laser, Panendoscopy diff --git a/099/surgery_report.txt b/099/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b77e45a107c14fdd4212b2a90ab1054f4e5e51f0 --- /dev/null +++ b/099/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, anesthesia is first induced by the anesthesia colleagues, rigid tracheobronchoscopy using O° optics and intubation by the first surgeon. Then transition to esophagogastroscopy, here insertion of the esophagoscope using a laryngoscope, passage of the upper sphincter is successful without any problems. Pre-mirroring into the stomach, air insufflation there by inversion, inconspicuous mucosal conditions on all sides. After aspiration of the air, slowly move back with the esophagoscope and inspect the gastroesophageal junction and the entire esophageal wall. Unobtrusive aspect on all sides. Enter with the Kleinsasser tube size C. In the edentulous maxilla, inspection of the oropharynx, hypopharynx and larynx as well as the base of the tongue. Inconspicuous aspect on all sides. There is no mass, smooth mucosa on all sides with very good visibility overall, final palpation of the base of the tongue without pathological findings. Now insertion of a spandex mouth retractor and suturing of the tongue, inspection of the tongue. Here, on the left, the previously described, coarsely palpable, but well demarcated from the surrounding tongue tissue and also well displaceable in relation to it, a mass approx. 5 x 3 cm in size and approx. 2 cm thick, in the anterior and upper 2/3 smooth aspect, caudal whitish verrucous aspect, overall not contact-vulnerable. After demonstrating the findings on , this was carefully excised from anterior to posterior in the healthy tissue using a diode laser and sent for histological processing with a suture marker. Subsequently, circumscribed hemostasis by means of bipolar coagulation and injection of 3 ml bupivacaine in the area of the lingual nerve for postoperative analgesia, after consultation with no frozen section and no marginal samples in the case of an overall rather benign aspect with e.g. papilloma or irritation fibroma in the area of the mandibular denture. Please proceed further after receiving the final histology. \ No newline at end of file diff --git a/100/InvasionFront_CD3_block19_x1_y4_patient100_0.json b/100/InvasionFront_CD3_block19_x1_y4_patient100_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cd209726214fc00205b9e4564ace89be4a278497 --- /dev/null +++ b/100/InvasionFront_CD3_block19_x1_y4_patient100_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5172.3, + "Centroid Y µm": 11843.7, + "Num Detections": 14580, + "Num Negative": 13988, + "Num Positive": 592, + "Positive %": 4.06, + "Num Positive per mm^2": 327.01 + } +} \ No newline at end of file diff --git a/100/InvasionFront_CD3_block19_x2_y4_patient100_1.json b/100/InvasionFront_CD3_block19_x2_y4_patient100_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9cc87ba3f0bf6a8ab1dc6e04b9fc55404f08f5d8 --- /dev/null +++ b/100/InvasionFront_CD3_block19_x2_y4_patient100_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7646.0, + "Centroid Y µm": 12068.6, + "Num Detections": 16257, + "Num Negative": 16089, + "Num Positive": 168, + "Positive %": 1.033, + "Num Positive per mm^2": 88.49 + } +} \ No newline at end of file diff --git a/100/InvasionFront_CD8_block19_x1_y4_patient100_0.json b/100/InvasionFront_CD8_block19_x1_y4_patient100_0.json new file mode 100644 index 0000000000000000000000000000000000000000..19c976a2dc00b340047c749bb336f1a69e9e2fad --- /dev/null +++ b/100/InvasionFront_CD8_block19_x1_y4_patient100_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4497.6, + "Centroid Y µm": 19614.6, + "Num Detections": 23838, + "Num Negative": 23536, + "Num Positive": 302, + "Positive %": 1.267, + "Num Positive per mm^2": 114.1 + } +} \ No newline at end of file diff --git a/100/InvasionFront_CD8_block19_x2_y4_patient100_1.json b/100/InvasionFront_CD8_block19_x2_y4_patient100_1.json new file mode 100644 index 0000000000000000000000000000000000000000..28ffc50d649d79ab2da5263dec81aae9bd177d58 --- /dev/null +++ b/100/InvasionFront_CD8_block19_x2_y4_patient100_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 19814.5, + "Num Detections": 21668, + "Num Negative": 20664, + "Num Positive": 1004, + "Positive %": 4.634, + "Num Positive per mm^2": 395.81 + } +} \ No newline at end of file diff --git a/100/TumorCenter_CD3_block19_x1_y4_patient100_0.json b/100/TumorCenter_CD3_block19_x1_y4_patient100_0.json new file mode 100644 index 0000000000000000000000000000000000000000..97e6378e6d63d2396b1cee06b15e5f6cecb7f253 --- /dev/null +++ b/100/TumorCenter_CD3_block19_x1_y4_patient100_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3922.9, + "Centroid Y µm": 12418.4, + "Num Detections": 19992, + "Num Negative": 19116, + "Num Positive": 876, + "Positive %": 4.382, + "Num Positive per mm^2": 351.27 + } +} \ No newline at end of file diff --git a/100/TumorCenter_CD3_block19_x2_y4_patient100_1.json b/100/TumorCenter_CD3_block19_x2_y4_patient100_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b876c4ca837fabc948bc91028a9467fc3475a857 --- /dev/null +++ b/100/TumorCenter_CD3_block19_x2_y4_patient100_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6446.6, + "Centroid Y µm": 11968.7, + "Num Detections": 20545, + "Num Negative": 19143, + "Num Positive": 1402, + "Positive %": 6.824, + "Num Positive per mm^2": 546.06 + } +} \ No newline at end of file diff --git a/100/TumorCenter_CD8_block19_x1_y4_patient100_0.json b/100/TumorCenter_CD8_block19_x1_y4_patient100_0.json new file mode 100644 index 0000000000000000000000000000000000000000..439042e2f302d07297ec1bdc5c692c67f45c2af5 --- /dev/null +++ b/100/TumorCenter_CD8_block19_x1_y4_patient100_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6329.4, + "Centroid Y µm": 21373.5, + "Num Detections": 23364, + "Num Negative": 22967, + "Num Positive": 397, + "Positive %": 1.699, + "Num Positive per mm^2": 159.95 + } +} \ No newline at end of file diff --git a/100/TumorCenter_CD8_block19_x2_y4_patient100_1.json b/100/TumorCenter_CD8_block19_x2_y4_patient100_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d831cfb83a6d6f1345cc148786bf060faaee7114 --- /dev/null +++ b/100/TumorCenter_CD8_block19_x2_y4_patient100_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8929.1, + "Centroid Y µm": 21322.6, + "Num Detections": 22612, + "Num Negative": 22141, + "Num Positive": 471, + "Positive %": 2.083, + "Num Positive per mm^2": 182.65 + } +} \ No newline at end of file diff --git a/100/history_text.txt b/100/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b39d0171ce119dd454fee83e25c21ca2323aff01 --- /dev/null +++ b/100/history_text.txt @@ -0,0 +1 @@ +Patient with histological evidence of a G2 squamous cell carcinoma in the left and right vocal fold with an extent of cT1b cN0 and indication for the above-mentioned measures. \ No newline at end of file diff --git a/100/icd_codes.txt b/100/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d220406bb9f820a9488c92a1fdebe2fb59920ef7 --- /dev/null +++ b/100/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 ] \ No newline at end of file diff --git a/100/ops_codes.txt b/100/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..91f6ef975854730c73ea9b4c73ba9d995e43e9f1 --- /dev/null +++ b/100/ops_codes.txt @@ -0,0 +1 @@ +Frontale Teilresektion des Larynx [Huet][5-302.6 ] Sonstige Temporäre Tracheostomie[5-311.x ] \ No newline at end of file diff --git a/100/patient_clinical_data.json b/100/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8c95adfe06d371a2dba334d0b7a98d8b9c4ec84a --- /dev/null +++ b/100/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 81, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/100/patient_pathological_data.json b/100/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..787325becd35f657e82ee2300cc5bc58535f4bfb --- /dev/null +++ b/100/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "100", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/100/surgery_description.txt b/100/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d649df05e1bc32e11cefeaff366e3a52ae0b85c6 --- /dev/null +++ b/100/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection, Tracheostomy creation diff --git a/100/surgery_report.txt b/100/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2f0cf7a274d2850b7c641ed93b87537158801d6e --- /dev/null +++ b/100/surgery_report.txt @@ -0,0 +1 @@ +Initial induction of anesthesia and transoral endotracheal intubation by the anesthesia colleagues and positioning of the patient by the surgeon. Application of local anesthesia prethyroidally. Skin ablation and sterile draping. Creation of an initial 6 cm incision from the thyroid cartilage horizontally through the subcutaneous tissue and platysma. Creation of a subplatysmal flap cranially to the thyroid incisura and caudally to the cricoid cartilage. Exposure and transection of the prelaryngeal musculature in the midline. Exposure of the thyroid cartilage, the ...................................cricothyroidea and the cricoid cartilage. Subsequent incision of the perichondrium. In the midline, develop a perichondrium flap postero-laterally pedicled on both sides of the thyroid cartilage. Exposure of the cartilage. Median thyrotomy, mucosal incision and access to the endolaryngeal space. This revealed a vocal fold completely affected from anterior to posterior up to the vocal process of the arytenoid cartilage with a slight extension into the morgue sinus as well as an involvement of the right vocal fold in the anterior two thirds without extension up to the parotid gland or into the subglottis. Thus, successive bypassing of the findings initially on the left side, macroscopically in healthy tissue. The arytenoid cartilage on the left side is spared but completely de-epithelialized. Subsequently, the anterior 2/3 of the right vocal fold was removed macroscopically in healthy tissue. Five marginal samples were then taken (left supraglottis, left subglottis, left arytenoid region, right supraglottis, right subglottis). All 5 marginal samples were found to be tumor-free by the pathology colleague. Hemostasis there by means of bipolar coagulation. Due to the large wound area of the de-epithelialized arytenoid cartilage and the patient's poor coagulation status, the decision was made to create a small tracheostoma and then to make another horizontal incision below the cricoid cartilage. Cut through the subcutaneous tissue and the platysma. Exposure and transection of the prelaryngeal musculature in the midline. Exposure of the thyroid isthmus, which is supplied and severed using bipolar coagulation. Exposure of the anterior wall of the trachea. Creation of a scalpel incision between the 2nd and 3rd tracheal cartilage clasp. Creation of a small Björk flap in the typical manner. Tracheostoma sutures, skin sutures and placement of an 8-bore tracheostomy tube. This is successful. Repeated endolaryngeal inspection. Dry conditions. Decision to insert a 16-gauge Keel prosthesis based on the corresponding wound surfaces. This is well fixed using Vicryl 3-0 sutures after drilling holes in the thyroid cartilage. Subsequent suture adaptation of the prelaryngeal muscles of the midline. Platysma suture. Single button skin suture. Application of a pressure bandage, completion of the procedure without complications. Conclusion: Problem-free partial laryngectomy according to Huet transcervical with creation of a small plastic tracheostoma. Due to the large wound area and the patient's poor coagulation status, please administer antibiotics with Sobelin 600 4 x daily intravenously for the next 7 days and nutrition via the nasogastric feeding tube for the next 7 days and present the patient to our interdisciplinary tumor conference as soon as possible after receiving the final histology. Please plan control MLE and Keel removal in 6-8 weeks. \ No newline at end of file diff --git a/101/InvasionFront_CD3_block7_x5_y2_patient101_0.json b/101/InvasionFront_CD3_block7_x5_y2_patient101_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1bc3465577885ba0f968712227988a2661ea28a1 --- /dev/null +++ b/101/InvasionFront_CD3_block7_x5_y2_patient101_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16666.2, + "Centroid Y µm": 4622.6, + "Num Detections": 16758, + "Num Negative": 16667, + "Num Positive": 91, + "Positive %": 0.543, + "Num Positive per mm^2": 43.34 + } +} \ No newline at end of file diff --git a/101/InvasionFront_CD3_block7_x6_y2_patient101_1.json b/101/InvasionFront_CD3_block7_x6_y2_patient101_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b99a8af80557f538e1ff5614bdbea621b5fdb72d --- /dev/null +++ b/101/InvasionFront_CD3_block7_x6_y2_patient101_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19164.9, + "Centroid Y µm": 4672.5, + "Num Detections": 21988, + "Num Negative": 21623, + "Num Positive": 365, + "Positive %": 1.66, + "Num Positive per mm^2": 160.89 + } +} \ No newline at end of file diff --git a/101/InvasionFront_CD8_block7_x5_y2_patient101_0.json b/101/InvasionFront_CD8_block7_x5_y2_patient101_0.json new file mode 100644 index 0000000000000000000000000000000000000000..009f4b5ea110a06a47815c9d5515ccaafdc92485 --- /dev/null +++ b/101/InvasionFront_CD8_block7_x5_y2_patient101_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 5896.9, + "Num Detections": 15355, + "Num Negative": 15181, + "Num Positive": 174, + "Positive %": 1.133, + "Num Positive per mm^2": 84.37 + } +} \ No newline at end of file diff --git a/101/InvasionFront_CD8_block7_x6_y2_patient101_1.json b/101/InvasionFront_CD8_block7_x6_y2_patient101_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2fceb9a07e861797f3f126f7ebd4dc994411272d --- /dev/null +++ b/101/InvasionFront_CD8_block7_x6_y2_patient101_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21063.8, + "Centroid Y µm": 6246.7, + "Num Detections": 18383, + "Num Negative": 18101, + "Num Positive": 282, + "Positive %": 1.534, + "Num Positive per mm^2": 128.84 + } +} \ No newline at end of file diff --git a/101/TumorCenter_CD3_block7_x5_y2_patient101_0.json b/101/TumorCenter_CD3_block7_x5_y2_patient101_0.json new file mode 100644 index 0000000000000000000000000000000000000000..621bc7c99f52b171162eeed092529bce86b5532d --- /dev/null +++ b/101/TumorCenter_CD3_block7_x5_y2_patient101_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 5372.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/101/TumorCenter_CD3_block7_x6_y2_patient101_1.json b/101/TumorCenter_CD3_block7_x6_y2_patient101_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e8b049ee25817676fc21be304c10752b865fc06b --- /dev/null +++ b/101/TumorCenter_CD3_block7_x6_y2_patient101_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 5222.2, + "Num Detections": 16235, + "Num Negative": 15355, + "Num Positive": 880, + "Positive %": 5.42, + "Num Positive per mm^2": 394.32 + } +} \ No newline at end of file diff --git a/101/TumorCenter_CD8_block7_x5_y2_patient101_0.json b/101/TumorCenter_CD8_block7_x5_y2_patient101_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7447112c56562e4c58cc82801cf836b2e9ac143e --- /dev/null +++ b/101/TumorCenter_CD8_block7_x5_y2_patient101_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 5472.1, + "Num Detections": 16443, + "Num Negative": 16411, + "Num Positive": 32, + "Positive %": 0.1946, + "Num Positive per mm^2": 15.22 + } +} \ No newline at end of file diff --git a/101/TumorCenter_CD8_block7_x6_y2_patient101_1.json b/101/TumorCenter_CD8_block7_x6_y2_patient101_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ba778f5a52e1ba504911490897f4d7902c8cd9b2 --- /dev/null +++ b/101/TumorCenter_CD8_block7_x6_y2_patient101_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18515.2, + "Centroid Y µm": 5697.0, + "Num Detections": 18464, + "Num Negative": 18009, + "Num Positive": 455, + "Positive %": 2.464, + "Num Positive per mm^2": 209.59 + } +} \ No newline at end of file diff --git a/101/history_text.txt b/101/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..04a43c48b34d217e95b15a992ecfe4c68d78ea5a --- /dev/null +++ b/101/history_text.txt @@ -0,0 +1 @@ +The patient underwent a panendoscopy and a cT3 cN2b oropharyngeal carcinoma on the left was histologically confirmed. The CT scan showed a mediastinal lymph node metastasis or lung metastasis. Bronchoscopy showed no evidence of malignancy, but a single round focus, which is .................. suspected of being malignant. This should be removed by thoracic surgery following surgical repair. \ No newline at end of file diff --git a/101/icd_codes.txt b/101/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/101/ops_codes.txt b/101/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a6859905f06264469039631089d567061282b2e --- /dev/null +++ b/101/ops_codes.txt @@ -0,0 +1 @@ +Pharyngotomie median translingual[5-290.1 ] Pharyngoplastik mit mikrovaskulär anastomosiertem Transplantat[5-293.2 ] Entnahme myokutaner Lappen mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.28 R] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] PEG-Sonde Anlage[5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Partielle Glossektomie transoral Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.02 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] \ No newline at end of file diff --git a/101/patient_clinical_data.json b/101/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..03568e805cadcefc287dda967de7135e1e3d9f4d --- /dev/null +++ b/101/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/101/patient_pathological_data.json b/101/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f28aec04bbed6f67d0c8bfd0de72ca2f72f18ec --- /dev/null +++ b/101/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "101", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/101/surgery_description.txt b/101/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..44e9534a2c7ae47753c2d6900b065c62b20c4a01 --- /dev/null +++ b/101/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Plastic tracheotomy, Free flap (ALT), PEG placement diff --git a/101/surgery_report.txt b/101/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4811f7c9355cdca107fe1f541867144a267f2285 --- /dev/null +++ b/101/surgery_report.txt @@ -0,0 +1 @@ +At the beginning of the operation, after induction of anesthesia by the anesthesia colleagues, a pharyngoscopy was performed to determine the exact extent of the tumor. An exophytic tumor was found in the area of the left tonsillar lobe, which almost filled the tonsillar lobe, but without significant involvement of the posterior pharyngeal wall or extensive transition into the soft palate. The tumor extends over the glossotonsillar groove into the base of the tongue and the edge of the tongue if the posterior floor of the mouth is intact. The edge of the tongue is clearly affected on the free lateral surface. Exulcerated tumor here. Anteriorly only the marginal area is infiltrated. The width of the tumor increases dorsally. Significant infiltration of the base of the tongue. Almost half of this is palpatorily infiltrated. Inspection of the vallecula. This is again free of tumor, as is the lateral wall of the pharynx. Palpatorily clear cervical lymph node metastasis as a conglomerate on the left. The rest of the pharynx and the endolarynx are clear. PEG tube was therefore initially inserted. Insertion with the gastroscope under laryngoscopic control. Problem-free pre-scanning into the stomach. After good diaphanoscopy, problem-free puncture of the stomach and insertion of the PEG tube using the usual suture pull-through method. Subsequent repositioning of the patient. First start with the enoral resection. Here, the tumor is first cut around with the electric needle. Then further dissection using the dissection technique. The left edge of the tongue is released while maintaining a safety distance of approx. 1.5 cm. Resection up to the edge of the tongue. Release of the tumor and lateral displacement, additional release of the part of the tonsil region. Deposition hard on the uvula, taking the anterior palatal arch with it. Resection up to the alveolar ridge while maintaining the safety distance. Partial removal of the pharyngeal muscles. Subsequent partial exposure of the soft tissue of the neck. Macroscopically, complete in sano conditions on all sides, as well as in the area of the sedimentation margins in the area of the mucosa. Release of the glossotonsillar groove and circumscribed involvement of the posterior floor of the mouth. Here, the tumor moves slightly into the depth, also poor overview in the area of the base of the tongue, therefore no further transoral resection is performed here. The area resected so far is completely covered with margin samples and diagnosed as in sano in the frozen section diagnostics. Now reposition for neck dissection on the left. To do this, make a curved skin incision on the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and dissection of the platysma. Creation of a platysma flap. Exposure of the anterior border of the sternocleidomastoid muscle. This is partially displaced. Free preparation of the muscle. When exposing the muscle, a clear infiltration can be seen approximately in the middle of the course. Therefore, after exposing the omohyoid muscle, the submandibular gland and the digastric muscle, the sternocleidomastoid muscle is exposed caudally and later cranially on the mastoid. After dissection of the borders, the internal jugular vein is now exposed. This shows that the metastasis clearly infiltrates the venous angle. Longer infiltration of the internal jugular vein and the outlet of the facial vein. Careful release of the metastasis in the area of the veins to preserve the superior thyroid vein and the cranial facial drainage. After removal of the internal jugular vein and mobilization of the metastasis, which is also partly located in the cervical plexus, a further extensive metastasis of approx. 4 x 5 cm is now visible behind the internal jugular vein. This infiltrates the internal jugular vein at the back, hence the caudal separation of the internal jugular vein. Exposure and preservation of the common carotid artery and the vagus nerve. Caudal evacuation of level V, also here several nodes, so that level V b is also evacuated. Here without visible visualization of the thoracic duct, but lymph leakage. Selective bipolar coagulation, if lymph leakage persists, later repositioning of the tissue and in case of incomplete reduction, application of TachoSil and TaboTamp. Evacuation and completion of the neck preparation with evacuation of level I b and level II a. The accessorius nerve was already resected in the 1st metastasis. After exposure of the entire digastric muscle, resection of the muscle, careful removal of the submandibular gland from the surrounding tissue, carefully preserving the cranially preserved facial branches. First expose and preserve the facial artery. This and the lingual artery are later dissected and removed. After releasing the submandibular gland with uncinate process from the floor of the mouth, tunneling to the resection area. Partial resection of the mylohyoid muscle with widening of the pharyngotomy. Entering the posterior floor of the mouth. Widening of the pharyngotomy and successive release and mobilization of the tumour. The entire soft tissue covering the outside of the tumor in the area of the floor of the mouth and cervically is removed. Exposure and exposure of the base of the tongue after extending the pharyngotomy caudally. Now a good overview and macroscopic complete resection of the base of the tongue. Due to the alteration and manipulation of the tissue, only a thin ridge remains between the tumor part in the tonsil region and the tumor part at the base of the tongue after excision of the tumor. The site is marked with a corresponding suture and the tumor is sent for definitive histology. This is followed by the taking of marginal samples, completely covering all edges. These are diagnosed in the area of the base of the tongue caudally, close to the tumor, with discrete residual infiltrates. Due to the thickness of the post-resectate, however, a minimum safety margin of 9 mm is required here. Otherwise, all other tumor margin samples are clear, so that an R0 situation can be assumed here. Now measure a lobulated graft measuring approx. 13 x 9 cm in total. Turn to graft harvesting from the right thigh. Here, after identification of the main perforator and 3 further secondary perforators by Doppler sonography, marking of the graft. Medial incision. Cut through the skin and subcutaneous tissue. Exposure and secure identification of the rectus femoris muscle. Slinging of the muscle. Strictly subfascial dissection. Identification of the pedicle vessel. Performing an extension incision. Further dissection of the pedicle and isolation. Release of the fascia above the intermedius portion. Complete cutting of the graft. Removal of the fascia lata. Caudal fascio cutaneous graft. Most of the perforators run with a small intramuscular course. Therefore use of a muscle cuff. Careful protection of the perforators. Isolation on the vascular pedicle and preparation of a strong artery and two draining veins with good confluence if the flap is properly vitalized. Deposition of the graft. Careful wound inspection. Insertion of a 10-gauge Redon drain and careful, two-layer wound closure with local balancing plasty in the area of excess skin. Neck dissection on the right side and plastic tracheotomy were performed at the same time. Neck dissection on the right: skin incision on the anterior edge of the sternocleidomastoid muscle. Dissection of skin and subcutaneous tissue. Exposure and dissection of the platysma. Exposure of the sternocleidomastoid muscle, the omohyoid muscle and the digastric muscle after exposure of the submandibular gland. Free preparation of the internal jugular vein. Preservation of the middle thyroid vein and the facial vein. Removal of the anterior neck preparation with careful protection of the hypoglossal nerve and the superior thyroid artery. Exposure of the accessorius nerve. Evacuation of the accessorius triangle with careful protection of the nerve and evacuation of level V with protection of the cervical plexus branches. Finally, wound inspection and, if the wound is dry, insertion of a 10-gauge Redon drain and two-layer wound closure. Tracheostomy: Insertion approx. 1 cm below the tracheostoma. Cut the skin and subcutaneous tissue horizontally. Exposure and ligation of the anterior jugular vein. Exposure of the infrahyoid musculature. Entering the linea alba. Exposure of the anterior surface of the cricoid cartilage. Exposure of the anterior surface of the trachea. Exposure and transection of the thyroid isthmus after perforation. Complete visualization of the anterior surface of the trachea. Insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björk flap and careful incision of the tracheostoma on all sides. In the case of small dehiscence for neck dissection with extensive resection, the paralaryngeal muscles are later adapted with the subcutaneous tissue so that reasonably tight conditions can be created here. The patient is then reintubated, initially onto an 8 mm tube and later onto a cannula with an inner core. This succeeds without any problems. Suture fixation of the cannula. The transplant is then inserted. This is done step by step transorally and transcervically. Gradual incorporation of the graft. This works well with a good fit. Good volume filling in the area of the base of the tongue. Intact conditions. The resection area extends caudally into the vallecula and in the area of the pharynx up to the entrance of the piriform sinus. After complete incision, dissection of the flap vascular pedicle. Thrombosis of the partially detached superior thyroid artery is now evident. Despite cutting back the artery, no equivalent blood flow and clear thrombosis. Therefore ligation. Also thrombosis of the detached facial and lingual arteries. Dissection of the transverse cervical artery. This has a widely tortuous course. Free dissection of the artery, providing good opportunities for rotation. Perform the arterial anastomosis with 8.0 Ethilon. This works very well. Tight conditions and immediate venous return flow. Now first dissection of an upper thyroid vein. This now shows clear thrombosis. Repeated irrigation with heparin does not lead to any relevant reflux. The facial vein is now dissected in the caudal direction. There is a branched course with palpatorily clear flow. After opening, the flow is regular so that this vein can now be used for connection after maximum mobilization of the artery. Performing the venous anastomosis with Coupler 3.5, which works well. Moderate tension conditions in relation to the arterial anastomosis. Regular flap vitality on inspection. Final inspection of the wound surfaces. Despite all the measures in level V b, there is still moderate lymphatic leakage after the above measures have been carried out, here with TachoSil and TaboTamp. Due to the arterial anastomosis via the arteria transversa cevicis, no further transpositions were necessary. Insertion of a guided 10 Redon drain and careful, two-layer wound closure. At the end of the operation, regular flap vitality and transfer of the patient to the intensive care unit on mechanical ventilation. Conclusion: Intraoperative R0-resected cT3 cN2b oropharyngeal carcinoma on the left with approx. 2/3 resection of the base of the tongue. Due to the extensive metastasis and aggressive local growth, adjuvant therapy is certainly urgently required. Please leave the cannula in place as long as possible postoperatively, for approx. 6 to 7 days, if the tracheostoma is clearly close to the left side of the neck with complex anastomosis. Depending on the left cervical lymph leakage, please start with conservative treatment. Strict avoidance of pressure bandages. Leave the 10 Redon drain in place until the flow rate is significantly reduced. Pull the Redon drainage by the surgeon. If the wound is healing properly, perform an X-ray gruel on the 10th postoperative day. Due to the extent of the tumor, the reconstruction and the patient's constitution, prolonged swallowing rehabilitation is to be expected. Depending on recovery of the general condition, planning of thoracic surgery to repair the round lung tumor. \ No newline at end of file diff --git a/102/InvasionFront_CD3_block20_x3_y6_patient102_0.json b/102/InvasionFront_CD3_block20_x3_y6_patient102_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0b69d76695c7414788bf036b139384d892c4bf0 --- /dev/null +++ b/102/InvasionFront_CD3_block20_x3_y6_patient102_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12377.7, + "Centroid Y µm": 14885.1, + "Num Detections": 17831, + "Num Negative": 17560, + "Num Positive": 271, + "Positive %": 1.52, + "Num Positive per mm^2": 114.76 + } +} \ No newline at end of file diff --git a/102/InvasionFront_CD3_block20_x4_y6_patient102_1.json b/102/InvasionFront_CD3_block20_x4_y6_patient102_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3715f84ba3e09805f005301315211f933cebb3d7 --- /dev/null +++ b/102/InvasionFront_CD3_block20_x4_y6_patient102_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14842.1, + "Centroid Y µm": 15067.0, + "Num Detections": 16589, + "Num Negative": 15807, + "Num Positive": 782, + "Positive %": 4.714, + "Num Positive per mm^2": 357.52 + } +} \ No newline at end of file diff --git a/102/InvasionFront_CD8_block20_x4_y6_patient102_1.json b/102/InvasionFront_CD8_block20_x4_y6_patient102_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b85d515ccfb78ca0e90252e6833282ad4402ae26 --- /dev/null +++ b/102/InvasionFront_CD8_block20_x4_y6_patient102_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14342.4, + "Centroid Y µm": 15042.0, + "Num Detections": 11647, + "Num Negative": 10696, + "Num Positive": 951, + "Positive %": 8.165, + "Num Positive per mm^2": 575.29 + } +} \ No newline at end of file diff --git a/102/TumorCenter_CD3_block20_x3_y6_patient102_0.json 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