diff --git a/709/history_text.txt b/709/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/709/surgery_description.txt b/709/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2b5d1c6907e9ce066ddeb08683eb3beca4631db4 --- /dev/null +++ b/709/surgery_description.txt @@ -0,0 +1 @@ +Tongue partial resection, Floor of mouth partial resection, Bilateral neck dissection, Defect coverage (Radial), Endoscopy diff --git a/709/surgery_report.txt b/709/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..64d7cbb3ca178cd9b96ca2d9c91ced09b389a2dc --- /dev/null +++ b/709/surgery_report.txt @@ -0,0 +1 @@ +First, after insertion of the mouth guard, re-inspection of the tumor region with the Kleinsasser microlaryngoscope. Now resection of the tongue tumor from the enoral side after insertion of the mouth guard, starting at the tip of the tongue, almost in the median line dorsally with the monopolar. The mass, which on the surface only appears as a small ulcer on the left side between the edge of the tongue and the floor of the mouth, shows extensive infiltrative growth in depth and spherical growth towards the body of the tongue. The tumor is now gradually bypassed dorsally towards the base of the tongue and resection is now performed in the area of the base of the tongue towards the floor of the mouth. Here, the tumor is also bypassed with an appropriate safety margin. The tumor also shows a cone-like growth in depth, which is carefully bypassed and lifted accordingly. The neck is now dissected, first on the left side. To do this, make a skin incision along the anterior edge of the sternocleidomastoid, ending in a skin fold. Dissection of the platysmal flap and dissection of the sternocleidomastoid anterior edge. Exposure of the vascular nerve sheath and further dissection along the omohyoid muscle to the hyoid bone. Dissection along the digastric muscle towards the base of the skull and removal of levels II, III and IV. Level V is then removed, as there are two macroscopically conspicuous lymph nodes in level IIa. All vascular and nerve structures in the neck area are spared after exposure and re-embedding of nerves X, XI, XII. This is followed by exposure and re-embedding of the marginal ramus and mandibular nerve and dissection and removal of level Ib, including the submandibular gland. This results in a thorough effect in the complete removal of the basal margin of the tumor. The large penetrating defect is used in the further course of the reconstruction, the pedicle pull-through. This is followed by neck dissection on the right side. The skin incision is the same as on the left. Dissection of the platysmal flap and exposure of the vascular nerve sheath. Careful evacuation of level II, III and IV without evidence of macroscopically conspicuous lymph nodes. Redon drainage is inserted here, subcutaneous and skin sutures are used. N. hypoglossus, N. accessorius and N. vagus are exposed and re-embedded. The next step is to lift the forearm graft after carefully measuring the tissue to be lifted. The graft is marked accordingly on the forearm, prepared and lifted from distal to proximal. The lifting ends in the area of the crook of the elbow and the superficial and deep venous system is taken along. The radial ramus superficial nerve is exposed and spared during dissection. The tourniquet is opened and careful hemostasis is performed. The graft is then removed and incorporated enorally to reconstruct the tongue and floor of the mouth. After appropriate incorporation, the vessels are anastomosed in the sense of an end-to-end anastomosis of the superior thyroid artery with the radial artery and end-to-end anastomosis of the flap vein with a branch of the facial vein using a size 3.0 coupler. Checking the vascular flows, which are excellent, and finally subcutaneous sutures and skin sutures here too. The lifting defect in the area of the right forearm is covered with full-thickness skin, which is lifted in the area of the right groin, and partially closed primarily. Application of a vacuum dressing and a Kramer splint to immobilize the forearm. The groin wound is treated with a Redon drain and closed primarily with subcutaneous sutures and skin sutures. After re-inspection of the findings, minimal swelling and a completely clear airway, a tracheostomy is not performed at this stage. This may have to be done secondarily. The vascular signals to be duplicated are drawn in the neck area. \ No newline at end of file diff --git a/710/history_text.txt b/710/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e80c1c77dd24a411a788d29b94db42eb8f485eda --- /dev/null +++ b/710/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the left in the anterior and lateral wall area. The above procedure was therefore indicated. Histologically squamous cell carcinoma. Previous panendoscopy without further findings. \ No newline at end of file diff --git a/710/icd_codes.txt b/710/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..50726a81362dded81ece0046930b4533393eade8 --- /dev/null +++ b/710/icd_codes.txt @@ -0,0 +1 @@ +ND 2-zeitig[C13.2 ] \ No newline at end of file diff --git a/710/ops_codes.txt b/710/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..02b586eff9572333c56ca55ac140165d8a0c341b --- /dev/null +++ b/710/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Permanente Tracheotomie[5-312.0 ] Transorale radikale Resektion des Pharynx [Pharyngektomie] sonstige[5-296.0x ] \ No newline at end of file diff --git a/710/patient_pathological_data.json b/710/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a0a0851ae2b277cd7314cff1fdc93ce6f8818cff --- /dev/null +++ b/710/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "710", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 35, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/710/surgery_description.txt b/710/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..87d61b66323b7e3792f00b52b99f494b2dd737aa --- /dev/null +++ b/710/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Tracheotomy diff --git a/710/surgery_report.txt b/710/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..44a082c0cc74bfc56e759501201839fcf7f81a9a --- /dev/null +++ b/710/surgery_report.txt @@ -0,0 +1 @@ +First position the patient after intubation. Insertion of mouth guard. Entry with the spreading laryngoscope. Positioning of the tumor. This appears slightly larger than described with slightly flatter extensions downwards and also medially. Endoscopically controlled laser resection of the tumor is now performed. The tumor is incised on all sides with a safety margin of at least 10 mm and removed macroscopically and microscopically in the healthy tissue. Resection includes the lateral arytenoid fold, anterior piriform sinus wall and lateral piriform sinus wall up to the tip, the piriform sinus caudally and the beginning of the base of the tongue cranially. The tumor is removed in several sections. Subsequently, edge samples are taken caudally from the adjacent piriform sinus, from the arytenoid fold on the left, from the piriform sinus entrance cranially as well as laterally from the area of the pharyngeal wall and laterobasally from the area of the still existing muscular pharyngeal wall. All marginal samples were tumor-free in the frozen section. Thus R0 status. Careful hemostasis is now performed. The operation is completed when the site is free of bleeding. Due to the patient's overall situation, a tracheostomy is initially not performed. The patient should be transferred to intensive care and extubated the next day in a controlled manner; if complications arise here, a tracheostomy is probably unavoidable. Neck dissection necessary on both sides at intervals with N+ status. Feeding via the inserted gastric tube and diet build-up after 5 to 7 days or swallowing training. Tracheotomy by and . Marking of the landmarks, sterile abjodation. Skin incision and dissection through the subcutaneous fatty tissue. Now strict perforation in the midline down to the prelaryngeal musculature, where a larger vein is ligated on both sides. Cut through the prelaryngeal muscles and push them aside. Now locate the cricoid cartilage and dissect the thyroid gland below the cricoid cartilage. Careful dissection of the trachea and undermining of the thyroid gland. Bipolar coagulation of the thyroid gland and transection of the thyroid gland. Exposure of the trachea using pedicle swabs. The trachea is now exposed in a clearly visible area. After consultation with the anaesthetist, enter the trachea between the 2nd and 3rd tracheal cartilage and create a visor tracheotomy. Suturing of the tracheostoma in the usual manner. Problem-free reintubation blocked on an 8 mm cannula. \ No newline at end of file diff --git a/711/InvasionFront_CD3_block19_x1_y10_patient711_0.json b/711/InvasionFront_CD3_block19_x1_y10_patient711_0.json new file mode 100644 index 0000000000000000000000000000000000000000..746d0556fa6146ef862af4f1a990929334db7e1f --- /dev/null +++ b/711/InvasionFront_CD3_block19_x1_y10_patient711_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 26585.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/711/InvasionFront_CD8_block19_x1_y10_patient711_0.json b/711/InvasionFront_CD8_block19_x1_y10_patient711_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0add64163acca9f931f5d3111e66bee24fd8707b --- /dev/null +++ b/711/InvasionFront_CD8_block19_x1_y10_patient711_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4147.8, + "Centroid Y µm": 34781.6, + "Num Detections": 11235, + "Num Negative": 10874, + "Num Positive": 361, + "Positive %": 3.213, + "Num Positive per mm^2": 251.06 + } +} \ No newline at end of file diff --git a/711/InvasionFront_CD8_block19_x2_y10_patient711_1.json b/711/InvasionFront_CD8_block19_x2_y10_patient711_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f38b8278cb5d02b33da2f4b25cdbf898e95d1dc --- /dev/null +++ b/711/InvasionFront_CD8_block19_x2_y10_patient711_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 34756.6, + "Num Detections": 16341, + "Num Negative": 16268, + "Num Positive": 73, + "Positive %": 0.4467, + "Num Positive per mm^2": 39.39 + } +} \ No newline at end of file diff --git a/711/TumorCenter_CD3_block19_x1_y10_patient711_0.json b/711/TumorCenter_CD3_block19_x1_y10_patient711_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6eb6d1b2a98e19fa75783c75f89fb8db15540d9 --- /dev/null +++ b/711/TumorCenter_CD3_block19_x1_y10_patient711_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6244.0, + "Centroid Y µm": 27138.6, + "Num Detections": 5387, + "Num Negative": 5086, + "Num Positive": 301, + "Positive %": 5.588, + "Num Positive per mm^2": 176.74 + } +} \ No newline at end of file diff --git a/711/TumorCenter_CD3_block19_x2_y10_patient711_1.json b/711/TumorCenter_CD3_block19_x2_y10_patient711_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e58575136cd801236326edbc13e20d6ee7c335f --- /dev/null +++ b/711/TumorCenter_CD3_block19_x2_y10_patient711_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8799.4, + "Centroid Y µm": 26681.1, + "Num Detections": 8698, + "Num Negative": 8006, + "Num Positive": 692, + "Positive %": 7.956, + "Num Positive per mm^2": 403.24 + } +} \ No newline at end of file diff --git a/711/TumorCenter_CD8_block19_x2_y10_patient711_1.json b/711/TumorCenter_CD8_block19_x2_y10_patient711_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0b4326e8810087ac6cc5e7b72b5c2cfef5025ed8 --- /dev/null +++ b/711/TumorCenter_CD8_block19_x2_y10_patient711_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9145.2, + "Centroid Y µm": 36255.8, + "Num Detections": 17560, + "Num Negative": 17126, + "Num Positive": 434, + "Positive %": 2.472, + "Num Positive per mm^2": 223.12 + } +} \ No newline at end of file diff --git a/711/history_text.txt b/711/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/711/icd_codes.txt b/711/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..39b400382d088fef026ef38595c4b9693b041747 --- /dev/null +++ b/711/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] Halslymphknotenmetastasen[C77.0 R] \ No newline at end of file diff --git a/711/ops_codes.txt b/711/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..88b7910d5cf0ce450c950f5b7f0f03368781903f --- /dev/null +++ b/711/ops_codes.txt @@ -0,0 +1 @@ +Laryngopharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie mit Rekonstruktion mit lokaler Schleimhaut[5-295.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Sonstige permanente Tracheostomie[5-312.x ] Inzision Zungengrund[5-250.x ] \ No newline at end of file diff --git a/711/patient_clinical_data.json b/711/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..567332eb70be4d2b4c086f460bee5166a73a0075 --- /dev/null +++ b/711/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 49, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/711/patient_pathological_data.json b/711/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ddbbd719274df716dd339f143e21dcd832a271a3 --- /dev/null +++ b/711/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "711", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/711/surgery_description.txt b/711/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..198741ddf26f3d7512486be0e3d5306dadc1dc68 --- /dev/null +++ b/711/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Partial pharyngectomy, Neck dissection diff --git a/711/surgery_report.txt b/711/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..15561c1a4f0bbfcdfdd80393274399feaa325d7c --- /dev/null +++ b/711/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Sterile washing and draping. Creation of an apron flap and start of neck dissection on the right side. The skin over the metastases is dissected off for this purpose; the platysma cannot be spared in part as it is adherent to the metastases. Exposure of the sternocleidomastoid muscle in the caudal region. Separation of the sternocleidomastoid muscle. Exposure of the internal jugular vein. Dissection of the large metastases from the internal jugular vein in the caudal region. Then removal of the omohyoid muscle. Dissection of the common carotid artery. Dissection of the division into external and internal carotid artery. Both divisions can be preserved, but the facial artery runs directly into the tumor. The superior thyroid artery also enters the tumor. The hypoglossal nerve and the accessory nerve extend into this metastatic tumor, as do the plexus branches, all of which are completely resected. The submandibular gland is partially resected. The neck conglomerate is sent for final histology with suture marking. Level II b is then removed and sent for histology. Neck dissection on the left side is performed by . After subplatysmal dissection of the apron flap up to the submandibular gland, the neck is dissected on the left side. Open the capsule of the submandibular gland and dissect in depth to expose the digastric muscle. Exposure of the accessorius nerve and exposure of the nerve. This can be completely preserved. Dissection of the neck specimen along the anterior venter of the digastric muscle and detachment of the specimen up to the hyoid bone. Exposure of the facial vein. Identification of the hypoglossal nerve. The facial vein can be preserved. Sharp dissection on the vein and lateral striking of the neck preparation. The vein can be completely detached from the neck specimen by inserting a .............................. The common carotid artery and vagus nerve are exposed. The neck preparation is now detached from the deep cervical fascia from cranial to caudal. Particular care is taken to spare the deep branches of the cervical plexus. The accessorius nerve is also not injured. After releasing the neck preparation, inspect the wound area. After hemostasis with the bipolar coagulation forceps, there is no further bleeding. After removal of the neck specimen at the level of the junction of the omohyoid muscle and the internal jugular vein, there is no evidence of a chyle fistula. Exposure of the outlets of the external carotid artery (the superior thyroid artery and the facial artery can be safely exposed and dissected). Completion of the neck dissection on the left side without complications. Now release of the larynx by . Skeletonization of the hyoid bone. Removal of the hyoid bone. Release of the piriform sinus. Neck level VI was removed beforehand. Then entering the pharynx from the left side. It can be seen that the tumor grows very far into the base of the tongue. Tumor resection with a safety margin of 1 ˝ cm. Cut down towards the postcricoid region, first on the left side, then on the right side. Some of the pharynx must also be resected on the right side. Then place the larynx below the cricoid cartilage and send the specimen marked with a suture for frozen section. All frozen sections are designated as R0, but at one point with a safety margin of just under 0.2 cm. A resection of the pharyngeal mucosa on the left side is taken, which is then also designated as R0. Now insertion of a Provox Vega prosthesis size 10 in the usual manner. Mobilization of the base of the tongue and the pharynx in the cranial region. Pharyngeal suture in the usual manner in two layers. A T-shaped suture must be applied in the area of the base of the tongue, as otherwise there is too much tension due to the relatively large amount of mucosa missing here. However, due to the overall situation of the patient and the still sufficient mucosa for a primary closure, the decision is made against a free graft or a pedicled graft. Finally, a mucocutaneous anastomosis is created at the tracheostoma. Insertion of Redon drains. Two-layer wound closure and completion of the procedure without complications. The patient is ventilated and admitted to the intensive care unit. Please continue antibiotics for at least 24 hours. X-ray gruel swallow in this case only after the 14th postoperative day. \ No newline at end of file diff --git a/712/InvasionFront_CD3_block2_x3_y10_patient712_0.json b/712/InvasionFront_CD3_block2_x3_y10_patient712_0.json new file mode 100644 index 0000000000000000000000000000000000000000..291e336be8692ff49cb0a63cbfdb5d18538ce82b --- /dev/null +++ b/712/InvasionFront_CD3_block2_x3_y10_patient712_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 38404.7, + "Num Detections": 23465, + "Num Negative": 20058, + "Num Positive": 3407, + "Positive %": 14.52, + "Num Positive per mm^2": 1312.4 + } +} \ No newline at end of file diff --git a/712/InvasionFront_CD3_block2_x4_y10_patient712_1.json b/712/InvasionFront_CD3_block2_x4_y10_patient712_1.json new file mode 100644 index 0000000000000000000000000000000000000000..62fa7f8f8f4d8f267ff9081da78c420f861237a9 --- /dev/null +++ b/712/InvasionFront_CD3_block2_x4_y10_patient712_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15841.6, + "Centroid Y µm": 38479.6, + "Num Detections": 23770, + "Num Negative": 20847, + "Num Positive": 2923, + "Positive %": 12.3, + "Num Positive per mm^2": 1131.5 + } +} \ No newline at end of file diff --git a/712/InvasionFront_CD8_block2_x3_y10_patient712_0.json b/712/InvasionFront_CD8_block2_x3_y10_patient712_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be830f779e1062c633140886e80eea81632d91ca --- /dev/null +++ b/712/InvasionFront_CD8_block2_x3_y10_patient712_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12243.5, + "Centroid Y µm": 26111.2, + "Num Detections": 22554, + "Num Negative": 20259, + "Num Positive": 2295, + "Positive %": 10.18, + "Num Positive per mm^2": 904.25 + } +} \ No newline at end of file diff --git a/712/InvasionFront_CD8_block2_x4_y10_patient712_1.json b/712/InvasionFront_CD8_block2_x4_y10_patient712_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2634a8666d053c2814c9c502aa5441ec48052c72 --- /dev/null +++ b/712/InvasionFront_CD8_block2_x4_y10_patient712_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14742.2, + "Centroid Y µm": 26236.1, + "Num Detections": 22862, + "Num Negative": 20649, + "Num Positive": 2213, + "Positive %": 9.68, + "Num Positive per mm^2": 881.66 + } +} \ No newline at end of file diff --git a/712/TumorCenter_CD3_block2_x3_y10_patient712_0.json b/712/TumorCenter_CD3_block2_x3_y10_patient712_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e53137ae2a559788d39863d6ee7fbffcac04d777 --- /dev/null +++ b/712/TumorCenter_CD3_block2_x3_y10_patient712_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 24462.0, + "Num Detections": 21274, + "Num Negative": 16498, + "Num Positive": 4776, + "Positive %": 22.45, + "Num Positive per mm^2": 1941.6 + } +} \ No newline at end of file diff --git a/712/TumorCenter_CD3_block2_x4_y10_patient712_1.json b/712/TumorCenter_CD3_block2_x4_y10_patient712_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b34fe0d760f96b417ab165762eebfc53717b87a6 --- /dev/null +++ b/712/TumorCenter_CD3_block2_x4_y10_patient712_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13342.9, + "Centroid Y µm": 24736.9, + "Num Detections": 18069, + "Num Negative": 15153, + "Num Positive": 2916, + "Positive %": 16.14, + "Num Positive per mm^2": 1466.2 + } +} \ No newline at end of file diff --git a/712/TumorCenter_CD8_block2_x3_y10_patient712_0.json b/712/TumorCenter_CD8_block2_x3_y10_patient712_0.json new file mode 100644 index 0000000000000000000000000000000000000000..721b9c753631082fa8ad591183e7b3e8761ae0f2 --- /dev/null +++ b/712/TumorCenter_CD8_block2_x3_y10_patient712_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13118.1, + "Centroid Y µm": 24761.9, + "Num Detections": 12220, + "Num Negative": 8940, + "Num Positive": 3280, + "Positive %": 26.84, + "Num Positive per mm^2": 2282.1 + } +} \ No newline at end of file diff --git a/712/TumorCenter_CD8_block2_x4_y10_patient712_1.json b/712/TumorCenter_CD8_block2_x4_y10_patient712_1.json new file mode 100644 index 0000000000000000000000000000000000000000..62542053b1ce44715ae4985fe90b14fd53da45fb --- /dev/null +++ b/712/TumorCenter_CD8_block2_x4_y10_patient712_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15791.6, + "Centroid Y µm": 24587.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/712/history_text.txt b/712/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/712/icd_codes.txt b/712/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a8da407527ff8def564f5ee0156d47f86fe53570 --- /dev/null +++ b/712/icd_codes.txt @@ -0,0 +1 @@ +Halslymphknotenmetastasen[C77.0 R] \ No newline at end of file diff --git a/712/ops_codes.txt b/712/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3ab79b82ae70c24fd046b48e28ffb138f3da91dc --- /dev/null +++ b/712/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Sonstige partielle Glossektomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.x2 ] Selektive Neck dissection in 4 Regionen[5-403.03 B] Sonstige permanente Tracheostomie[5-312.x ] Sonstige perkutan-endoskopisch Gastrostomie (PEG)[5-431.2x ] Partielle Exzision [erkrankter] harter und weicher Gaumen[5-272.1 ] Extraktion mehrerer Zähne eines Quadranten[5-230.2 ] Wechsel eines vaskulären Implantates[5-394.3 ] Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Spalthaut Entnahmestelle sonstige[5-901.0x R] Spalthautdeckung auf granulierendes Hautareal großflächig Empfängerstelle Unterarm[5-902.58 L] \ No newline at end of file diff --git a/712/patient_clinical_data.json b/712/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9bc821bf9dec78868d4a3cef6ceab6b26dd2e72d --- /dev/null +++ b/712/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/712/patient_pathological_data.json b/712/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fb945564677416b9045560a70b81dbef53dea978 --- /dev/null +++ b/712/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "712", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 14.0 +} \ No newline at end of file diff --git a/712/surgery_description.txt b/712/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9166e5d7144a7fb9e735bc8ab6e59ed2bfd9f614 --- /dev/null +++ b/712/surgery_description.txt @@ -0,0 +1 @@ +Combined tumor resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), PEG placement, Tracheotomy diff --git a/712/surgery_report.txt b/712/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ec2a804e28eaf1c9663e2bd6e649e16667082e92 --- /dev/null +++ b/712/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthetist, then sterile washing and draping. Insertion of a covered retractor. Snare the tongue, then inspect the tumor region. The tumor extends from the base of the tongue to the tonsil region to the anterior and posterior palatal arch and passes over to the soft palate and extends to the base of the uvula, but does not infiltrate it. First transoral tumor resection using a monopolar needle, scissors and bipolar forceps so that the tumor is detached from the soft palate and the tonsil region as well as from the tongue margin. Then switch to the transcervical approach. To do this, make a skin incision in a transverse skin fold 2 ˝ cm below the lower jaw. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Showing the submandibular gland. Exposure of the cervical vascular sheath. First resection of the submandibular gland. The lower part of the tumor is then immediately encountered. A pharyngotomy is performed here, then the tumor is dislocated transcervically and successively cut around. It can be removed en bloc. The entire tumor is then thread-marked and sent for frozen section. In the frozen section, all edges are tumor-free. Basally in the area of the tongue, the margins are only very narrowly resected. Therefore, a resection is made here again, which is sent for final histology. Now complete the neck dissection. For this, free preparation of the internal jugular vein. Exposure of the N. accessorius, the V. facialis, which must be removed, the A. thyroidea superior and removal of the neck IIa to Va while sparing the plexus branches. Measurement of the defect reveals a fairly large defect in the area of the edge of the tongue and the oropharynx. The flap is then configured so that one part can cover the posterior pharyngeal wall and one part goes to the tongue with a notch so that the tongue is not fixed later. This graft is drawn onto the forearm. Then cut around the skin. Exposure of the brachioradialis muscle. Exposure of the cephalic vein, exposure of the deep venous system in the crook of the elbow. The patient has no direct confluence in the crook of the elbow between the superficial and deep systems. The cephalic vein is therefore directly integrated with the graft. Exposure of the superficial ramus, radial nerve, this divides into 2 branches, unfortunately one branch cannot be preserved, but the larger main branch remains. Then visualization of the radial artery, clamping, ligation and repositioning of the radial artery. Detach the graft from the tendon bed, then dissect the pedicle in the usual way. Smaller vessels are clipped and bipolar coagulated. Then dissection of the vessel outlet in the elbow area. Exposure and identification of the ulnar and interosseous arteries. The radial artery is removed distally from its outlet. The cephalic vein and a larger accompanying vessel of the radial artery are dissected for the venous connection. The arm is then closed in the usual way using split skin. Neck dissection on the left side and tracheotomy by are now performed in parallel with graft elevation. Now proceed to the tracheotomy: First mark the landmarks (jugulum, cricoid cartilage, thyroid incisura). Mark the skin incision. This is located at mid-height between the jugulum and the cricoid cartilage. Skin incision at a length of approx. 4 cm. Dissection through the subcutaneous tissue. Two larger veins must be ligated and cut. Then dissect the linea alba of the infrahyoid musculature. Spread the muscles apart. Finding the thyroid isthmus. This is now dissected along the trachea. Then insertion of the Pean clamps and transection of the isthmus after bipolar coagulation. Ligation of the left and right isthmus. Free preparation of the trachea. Entering the trachea after preoxygenation between the 2nd and 3rd tracheal cartilage. Formation of a Björk flap and tracheocutaneous anastomosis in the typical manner. Retubing of the patient to a 9-gauge cannula. Proceed to neck dissection on the left side. The incision is first made at a length of approx. 7 to 8 cm, approx. 2 transverse fingers below the mandible in a skin fold. Dissection through the subcutaneous tissue. Exposure and separation of the platysma and formation of a platysmal flap. This is exposed cranially and caudally. The anterior edge of the sternocleidomastoid muscle is then dissected caudally to the omohyoid muscle, which is then dissected cranially/medially. Further dissection of the anterior edge of the sternocleidomastoid muscle. Locate the submandibular gland. Dissection of the caudal glandular capsule and insertion into the anterior neck preparation. Locate the digaster venter muscle posteriorly and move along it anteriorly as far as the hyoid. Release the anterior neck preparation while protecting the hypoglossal nerve, which can be visualized and protected. Now dissect the cervical vascular sheath. The internal jugular vein and facial vein are exposed and spared. The common carotid artery and external carotid artery are exposed and spared, as are the vagus nerve and the cervical artery. The accessorius nerve is then explored. Dissection of level II b. Detachment of the fatty tissue with the lymph nodes along the sternocleidomastoid muscle and the internal jugular vein to level IV caudally, level V is also removed. The fatty tissue is ligated and removed caudally in level IV. Detachment of the lateral neck preparation. Subsequent insertion of an 8 Redon drain. Subcutaneous suture with 3.0 Vicryl and skin suture with 4.0 Ethilon. Now insertion of the graft, first transcervically, then transorally. This is relatively difficult as the uvula, tongue and the entire oral mucosa are very swollen. In the end, the graft can be inserted completely. The vessels for the anastomosis are now exposed. For this purpose, the superior thyroid artery and the facial vein as well as an outlet from the internal jugular vein are taken. Finally, an artery and two veins are connected, which is successful without any problems and ensures good perfusion in the graft area. Insertion of a flap and two-layer wound closure. Re-intubation to a 9 mm tracheostomy tube. The patient is ventilated and admitted to the intensive care unit. Please X-ray pre-swallow on the 10th postoperative day, until then nutrition via the previously inserted PEG tube. The PEG tube was inserted with good diaphanoscopy using the thread pull-through method. \ No newline at end of file diff --git a/713/InvasionFront_CD3_block15_x5_y4_patient713_0.json b/713/InvasionFront_CD3_block15_x5_y4_patient713_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7e2e91ec5e30df33379adcfedbda260a2f4d9f2f --- /dev/null +++ b/713/InvasionFront_CD3_block15_x5_y4_patient713_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 19864.5, + "Num Detections": 20199, + "Num Negative": 17185, + "Num Positive": 3014, + "Positive %": 14.92, + "Num Positive per mm^2": 1246.5 + } +} \ No newline at end of file diff --git a/713/InvasionFront_CD3_block15_x6_y4_patient713_1.json b/713/InvasionFront_CD3_block15_x6_y4_patient713_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2ace1756a427019e2e5e832386fe4fbc487ce90a --- /dev/null +++ b/713/InvasionFront_CD3_block15_x6_y4_patient713_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20664.1, + "Centroid Y µm": 19589.6, + "Num Detections": 20088, + "Num Negative": 17650, + "Num Positive": 2438, + "Positive %": 12.14, + "Num Positive per mm^2": 954.01 + } +} \ No newline at end of file diff --git a/713/InvasionFront_CD8_block15_x5_y4_patient713_0.json b/713/InvasionFront_CD8_block15_x5_y4_patient713_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f43703bc9cff6130ff43b936a53b02f882345634 --- /dev/null +++ b/713/InvasionFront_CD8_block15_x5_y4_patient713_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16194.7, + "Centroid Y µm": 9737.2, + "Num Detections": 17759, + "Num Negative": 16260, + "Num Positive": 1499, + "Positive %": 8.441, + "Num Positive per mm^2": 671.65 + } +} \ No newline at end of file diff --git a/713/InvasionFront_CD8_block15_x6_y4_patient713_1.json b/713/InvasionFront_CD8_block15_x6_y4_patient713_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5598ecac88c4675f855b433c4ce6c5a0c86fe36f --- /dev/null +++ b/713/InvasionFront_CD8_block15_x6_y4_patient713_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18853.6, + "Centroid Y µm": 9726.3, + "Num Detections": 17759, + "Num Negative": 16885, + "Num Positive": 874, + "Positive %": 4.921, + "Num Positive per mm^2": 400.78 + } +} \ No newline at end of file diff --git a/713/TumorCenter_CD3_block15_x5_y4_patient713_0.json b/713/TumorCenter_CD3_block15_x5_y4_patient713_0.json new file mode 100644 index 0000000000000000000000000000000000000000..93ec7c73620383c955c1e6cc4fdb765772b03c47 --- /dev/null +++ b/713/TumorCenter_CD3_block15_x5_y4_patient713_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16491.3, + "Centroid Y µm": 13293.0, + "Num Detections": 17843, + "Num Negative": 13601, + "Num Positive": 4242, + "Positive %": 23.77, + "Num Positive per mm^2": 1887.0 + } +} \ No newline at end of file diff --git a/713/TumorCenter_CD3_block15_x6_y4_patient713_1.json b/713/TumorCenter_CD3_block15_x6_y4_patient713_1.json new file mode 100644 index 0000000000000000000000000000000000000000..736329f5041b3a3803a7be68d58550f3df172e04 --- /dev/null +++ b/713/TumorCenter_CD3_block15_x6_y4_patient713_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 13317.9, + "Num Detections": 18702, + "Num Negative": 16655, + "Num Positive": 2047, + "Positive %": 10.95, + "Num Positive per mm^2": 953.41 + } +} \ No newline at end of file diff --git a/713/TumorCenter_CD8_block15_x5_y4_patient713_0.json b/713/TumorCenter_CD8_block15_x5_y4_patient713_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f8dc54d0f273e6630755830e1b24660c5a822f93 --- /dev/null +++ b/713/TumorCenter_CD8_block15_x5_y4_patient713_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 9919.7, + "Num Detections": 17854, + "Num Negative": 15701, + "Num Positive": 2153, + "Positive %": 12.06, + "Num Positive per mm^2": 976.28 + } +} \ No newline at end of file diff --git a/713/TumorCenter_CD8_block15_x6_y4_patient713_1.json b/713/TumorCenter_CD8_block15_x6_y4_patient713_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5a028503dc3c5cddca426310f76a9e8afbf5a163 --- /dev/null +++ b/713/TumorCenter_CD8_block15_x6_y4_patient713_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21438.6, + "Centroid Y µm": 9894.8, + "Num Detections": 19887, + "Num Negative": 19088, + "Num Positive": 799, + "Positive %": 4.018, + "Num Positive per mm^2": 348.02 + } +} \ No newline at end of file diff --git a/713/history_text.txt b/713/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f2ce94eaf93f2b3342c2aa0125105ca1bd47019c --- /dev/null +++ b/713/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tongue margin carcinoma on the right. Extension to the midline and cones in the direction of the external musculature or floor of mouth muscles. Therefore, the above-mentioned surgery is indicated. \ No newline at end of file diff --git a/713/icd_codes.txt b/713/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7bea55e77b75c7f00dc590613d7a4fc4fd7d6f50 --- /dev/null +++ b/713/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkrebs[C02.1 R] \ No newline at end of file diff --git a/713/ops_codes.txt b/713/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1d04fa6bfe000dbc6bd9b57c793c6864af3e65c5 --- /dev/null +++ b/713/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Transplantat[5-295.14 ] Selektive Neck dissection in 4 Regionen[5-403.03 B] Permanente Tracheotomie[5-312.0 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Diagnostische Ösophagogastroskopie: Bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Zirkuläres Klammernahtgerät für die Anwendung bei Gefäßanastomosen (Zusatzkode)[5-98c.3 ] \ No newline at end of file diff --git a/713/patient_clinical_data.json b/713/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3fa97a58e74be482f871246443a20da94abd397b --- /dev/null +++ b/713/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 49, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/713/patient_pathological_data.json b/713/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1fb32cbc8b5c511307637c7237be490243f88d60 --- /dev/null +++ b/713/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "713", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 14.0 +} \ No newline at end of file diff --git a/713/surgery_description.txt b/713/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..eba8120908574e8b2c514322342d110cb5665aaa --- /dev/null +++ b/713/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection with almost hemiglossectomy, Neck dissection, Tracheostomy and PEG placement, Defect coverage diff --git a/713/surgery_report.txt b/713/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2160b3f7922be0692d68e16dda731b7b10605ee6 --- /dev/null +++ b/713/surgery_report.txt @@ -0,0 +1 @@ +First, laryngoscopy and pharyngoscopy again: confirmation of tumor spread and the probability of flap coverage. Subsequent PEG insertion: insertion of the esophagoscope. After creation of the diaphanoscopy, insertion of a 15 mm abdominal wall probe without complications. Fixation to the abdominal wall in the typical manner. Then repositioning for transoral tumor resection: insertion of the retractors and insertion of the tongue bridle suture. Successive removal of the tumor with a safety margin of at least 1.5 cm on all sides, also in the area of the soft tissue of the tongue. This results in a complete hemiglossectomy except for the anterior tip of the tongue, which crosses the midline in the posterior region and extends down to the base of the tongue. The glossoalveolar groove and the beginning of the tonsil lobe are also resected. The lingual nerve is partially preserved, as is the wharton duct. Tumor is completely removed macroscopically in the healthy tissue. Tumor is thread-marked. The uncinate process is removed basally as a marginal sample, as are parts of the mylohyoid muscle and external tongue muscles as basal marginal samples in the front. In addition, an extensive marginal sample of the floor of the mouth/base of tongue muscles from the area of the glossotonsillar groove to the base of the tongue. The latter two marginal samples, as well as the entire preparation, are thread-marked for frozen section. In the frozen section, the specimen and all marginal specimens are removed in healthy tissue, thus R0 resection. Measure the size of the flap, which is 12 x 6-7 cm. Careful hemostasis. Subsequent repositioning for continuation of the operation. Skin disinfection and sterile draping of all necessary surgical areas including the left forearm and right thigh. Neck dissection on the right is performed by : Skin incision in typical manner, exposure of sternocleidomastoid muscle anterior border, dissection of fat lymph node preparation. Exposure of the internal jugular vein, external jugular vein, facial vein. Exposure of internal carotid artery, external carotid artery, exposure of vagus nerve, accessorius nerve and hypoglossal nerve. All structures are preserved. Removal of the fat lymph node preparation from levels II to IV as well as Va and b below the branches of the cervical plexus. Neck dissection on the left side is then performed by and is carried out in the same way as on the right side with removal of levels II to V. Then tracheostoma creation: this is performed by . Small Kocher collar incision. Exposure of infrahyoid muscles, division of these. Exposure of the thyroid isthmus, which is undercut, clamped, severed and supplied by puncture ligation. Exposure of the trachea. Entering the trachea in the 2nd/3rd intercartilaginous space. Creation of a wide pedicled modified Björk flap. Epithelialization of this. Re-intubation and insertion of an 8 mm Woodbridge tube. Then radialis flap harvesting: marking of the flap size, this is 12 x 7 cm. The flap is first lifted subfacially from the ulnar side. The incision is then extended to the elbow. Then expose the superficial venous system and lift it subfascially. Then expose the connection to the deep venous system. The flap is then lifted off radially. This is done subfascially. Exposure of the lateral antebrachial cutaneous nerve. This is preserved. Distal exposure of the radial vein and artery, which is first clamped. After sufficient clamping time with always sufficiently high saturation of 95 to 100 %, the radial artery is removed. Successive lifting of the flap with the pedicle subfascially. Smaller vessels are clipped or bipolar coagulated. Exposure of the entry of the radial artery into the brachial artery in the antecubital fossa. After clamping and a certain necessary waiting time, the interosseous artery is supplied with clips and cut. A large venous outlet from the cephalic vein can be visualized in the antecubital fossa. The confluence can also be visualized, although it is very small. Finally, the radial artery is first removed at the brachial artery. Treatment with 6-0 Vascufil sutures over and under. Hand perfusion then remains stable. Removal of the veins. These are ligated proximally in the stumps. The flap pedicle is then flushed with heparin via the veins and artery. The flap is now inserted enorally into the defect. The stalk is passed through a tunnel into the neck parts; the submandibular gland is resected first. The Wharton's duct is cut off. The lingual nerve is preserved as far as possible. A sufficiently wide tunnel is now created. The stalk is inserted into the soft tissues of the neck on the right. The flap is initially sutured into the defect with 3-0 Vicryl single button sutures, partly by advancing the flap and preserving the continuous pedicle. The defect can be covered completely and without tension. The vessels are then conditioned. After conditioning, the radial artery is anastomosed with the superior thyroid artery using 9-0 Ethilon single-button sutures. After opening the clamps, good arterial flow and good venous return. The two outlets of the superficial venous system are then conditioned. The external jugular artery is removed, ligated proximally and supplied distally with a clamp, flushed with heparin and conditioned. The V. thyroidea media is also removed and rinsed with heparin and conditioned after clamping and removal with ligation. The anastomosis between the larger outlet of the superficial venous system and the external jugular vein is performed using a 3-0 coupler. After opening the clamp, good venous return, positive smear phenomenon. Subsequent anastomosis between the smaller outlet of the cephalic vein and the V. thyroidea media with a 2.5 mm coupler. This was also without complications, positive smear phenomenon, good venous return. The flap pedicle is then inserted into the soft tissues of the neck and sutured slightly medio-cranially to prevent tortuosity. The sides of the neck are completely irrigated and extensive hemostasis is performed. The wound was closed in layers by inserting a Redon drain on the left and 2 Penrose drains on the right, which were fixed with sutures and the tracheostoma was epithelized. In the forearm area, the wound is closed proximally in layers. The skin is then closed using split skin. This is first removed from the right thigh in a sufficient size of approx. 13 x 7 cm. A hydrocolloid dressing is applied to the thigh. The split skin is gradually worked into the defect, creating a complete tension-free wound closure. Octenidin gel is applied to the split skin and Mepilex is applied on top. Loose compresses are applied to the Mepilex. The forearm is then wrapped in absorbent cotton. Fitting of a Cramer splint. Fixation with a tape bandage in the functional position of the hand. Hand always sufficiently and well supplied with blood until the end. Attachment of the arm. Checking the flap enorally. This is well supplied with blood. Woodbridge tube is replaced between 8 mm tracheal cannula which is fixed with sutures. The sites of the vascular anastomoses are marked on the skin using sutures. The procedure is completed without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue the antibiotic treatment, which was started intraoperatively with Unacid, for one week postoperatively. Feeding via the PEG tube for 7-10 days, then dietary support according to flap status. If necessary, X-ray paps. Heparin perfusor, which was started intraoperatively at 500 E/h, should be continued postoperatively for 5 days. Flap control according to the scheme clinically by enoral inspection or also by checking the Doppler probe. Overall cT2-3 tongue margin carcinoma also tending towards cT4 due to infiltration of the external tongue muscles and the floor of the mouth. Waiting for the postoperative histology and presentation at the interdisciplinary tumor conference regarding adjuvant therapy. \ No newline at end of file diff --git a/714/InvasionFront_CD8_block3_x5_y12_patient714_0.json b/714/InvasionFront_CD8_block3_x5_y12_patient714_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0b3061149ea0992fc32c1852815dce7fb08212f3 --- /dev/null +++ b/714/InvasionFront_CD8_block3_x5_y12_patient714_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17240.9, + "Centroid Y µm": 29709.3, + "Num Detections": 19360, + "Num Negative": 18516, + "Num Positive": 844, + "Positive %": 4.36, + "Num Positive per mm^2": 344.3 + } +} \ No newline at end of file diff --git a/714/InvasionFront_CD8_block3_x6_y12_patient714_1.json b/714/InvasionFront_CD8_block3_x6_y12_patient714_1.json new file mode 100644 index 0000000000000000000000000000000000000000..931e906e363e2f3ebadbf15c3bfa9364447c42a5 --- /dev/null +++ b/714/InvasionFront_CD8_block3_x6_y12_patient714_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19739.5, + "Centroid Y µm": 29609.3, + "Num Detections": 20446, + "Num Negative": 20161, + "Num Positive": 285, + "Positive %": 1.394, + "Num Positive per mm^2": 123.13 + } +} \ No newline at end of file diff --git a/714/TumorCenter_CD3_block3_x5_y12_patient714_0.json b/714/TumorCenter_CD3_block3_x5_y12_patient714_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cc64793a557fba69d6e8dea146458117654b6d4f --- /dev/null +++ b/714/TumorCenter_CD3_block3_x5_y12_patient714_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15280.2, + "Centroid Y µm": 36291.4, + "Num Detections": 16286, + "Num Negative": 14829, + "Num Positive": 1457, + "Positive %": 8.946, + "Num Positive per mm^2": 645.89 + } +} \ No newline at end of file diff --git a/714/TumorCenter_CD3_block3_x6_y12_patient714_1.json b/714/TumorCenter_CD3_block3_x6_y12_patient714_1.json new file mode 100644 index 0000000000000000000000000000000000000000..478dde27ef2fcb44ec57095c9a69a56c2b8d36f2 --- /dev/null +++ b/714/TumorCenter_CD3_block3_x6_y12_patient714_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17665.6, + "Centroid Y µm": 36380.7, + "Num Detections": 13130, + "Num Negative": 12322, + "Num Positive": 808, + "Positive %": 6.154, + "Num Positive per mm^2": 432.95 + } +} \ No newline at end of file diff --git a/714/TumorCenter_CD8_block3_x5_y12_patient714_0.json b/714/TumorCenter_CD8_block3_x5_y12_patient714_0.json new file mode 100644 index 0000000000000000000000000000000000000000..73f40755bcdee38e8ff104153de3944db8af2652 --- /dev/null +++ b/714/TumorCenter_CD8_block3_x5_y12_patient714_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15441.8, + "Centroid Y µm": 31283.4, + "Num Detections": 18423, + "Num Negative": 18085, + "Num Positive": 338, + "Positive %": 1.835, + "Num Positive per mm^2": 140.75 + } +} \ No newline at end of file diff --git a/714/TumorCenter_CD8_block3_x6_y12_patient714_1.json b/714/TumorCenter_CD8_block3_x6_y12_patient714_1.json new file mode 100644 index 0000000000000000000000000000000000000000..478732bac0b0155b828d2b8db4a6448c580583bd --- /dev/null +++ b/714/TumorCenter_CD8_block3_x6_y12_patient714_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17915.5, + "Centroid Y µm": 31658.2, + "Num Detections": 16102, + "Num Negative": 15926, + "Num Positive": 176, + "Positive %": 1.093, + "Num Positive per mm^2": 85.83 + } +} \ No newline at end of file diff --git a/714/history_text.txt b/714/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..739bccf0631b50b355881252f19ac15694e7ff53 --- /dev/null +++ b/714/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the left oropharynx, HBV and p16 negative. Due to the size and depth of growth, defect coverage using a flap was indicated. \ No newline at end of file diff --git a/714/icd_codes.txt b/714/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..da55c7511d068fc0b0dfe7e6a45d4d38eecf0a89 --- /dev/null +++ b/714/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/714/ops_codes.txt b/714/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..82af9a28071fe3ce4b58f1e3df866c7973c5ab2d --- /dev/null +++ b/714/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 B] Transorale Tumortonsillektomie[5-281.2 ] Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Spalthaut großflächig Empfängerstelle sonstige[5-902.4x L] Temporäre Tracheotomie[5-311.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Transplantat[5-295.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Sonstige Inzision und Schlitzung Speicheldrüse und Ausführungsgang Glandula submandibularis[5-260.x L] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/714/patient_clinical_data.json b/714/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..633f8d5c6f21acc4349ff48dcfaa7434f1645a9b --- /dev/null +++ b/714/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 54, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 59, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/714/patient_pathological_data.json b/714/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7350f94a9758f151c4d652b32b12c3888dc5646e --- /dev/null +++ b/714/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "714", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/714/surgery_description.txt b/714/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..06ce221c941d282c3f4fc5be8d4caad00a236554 --- /dev/null +++ b/714/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Right-sided neck dissection, Defect coverage, Free flap (Radial) diff --git a/714/surgery_report.txt b/714/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1b628a5f2f41b0e49a4fde60ca2abbe1aa5cffe --- /dev/null +++ b/714/surgery_report.txt @@ -0,0 +1 @@ +First of all, position the patient again and perform the pharyngoscopy and laryngoscopy: The exophytic tumor is seen, which extends from the tonsil lobe next to the uvula over the side wall into the base of the tongue or into the piriform sinus entrance. Due to the poor mouth opening and the narrow conditions, tracheostoma placement is now absolutely necessary before tumor resection for a better overview. PEG insertion: insertion of the esophagoscope. Pre-viewing into the stomach, insertion of a 15 mm abdominal wall tube in a typical manner after establishing a sufficient diaphanoscopy. This is also fixed to the stomach wall in a typical manner without any problems. Now sterile draping of all areas, injection of a total of 20 ml Ultracaine 1% with adrenaline into both sides of the neck. First tracheostoma placement by and . Small Kocher collar incision, dissection through the subcutaneous tissue to the infrahyoid musculature, which is split. Exposure of the thyroid isthmus, which is passed underneath, clamped, cut and supplied by means of a puncture ligature. Subsequent exposure of the trachea. Small visor flap or modified Björk flap. Epithelialization of this. Subsequent reintubation. Neck dissection on the left: Incision typically extended slightly caudally and cranially. Exposure of sternocleidomastoid muscle, exposure of digastric muscle, omohyoid muscle. Cranially there is a conglomerate of lymph nodes, which clinically corresponds to metastases. Visualization of the internal jugular vein, facial vein. Visualization of the internal carotid artery, external carotid artery, superior thyroid artery, facial artery and lingual artery. Exposure of vagus nerve, accessorius nerve, border cord and hypoglossal nerve. Clearing level II-V. Subsequent removal of the submandibular gland, including removal of some level Ib lymph nodes. Wharton's duct is ligated. The digastric muscle was also resected. Branches of the cervical plexus were exposed and preserved. Subsequent exposure of the internal and external carotid arteries and the internal jugular vein as well as the vagus nerve, hypoglossal nerve and glossopharyngeal nerve, initially up to the base of the skull. Nerves are dissected from the pharyngeal wall with vessel loops. The pharyngeal wall is lifted away from the prevertebral fascia. All soft tissues except for the hypoglossal nerve are mobilized towards the pharyngeal wall. The lateral hyoid bone and the upper parts of the superior concha are also mobilized. The lingual artery is ligated and turned laterally, as are the vein and facial artery. Then, starting transorally, the tumor is resected cranially with the entire wall. This is done caudally as far as the overview allows. Subsequently, further resection of the tumor from the transcervical side. Tumor is removed with a safety margin of at least 1.5 cm, in some cases up to 2 cm on all sides. Macroscopically clear in healthy tissue. The palatal arch falls to the left of the uvula both anteriorly and posteriorly, resection quite close to the tube. Pharyngeal wall in the area of the posterior wall up to the middle. Complete lateral wall up to the floor of the mouth in front. Resection extends into the piriform sinus, also includes parts of the vallecula up to the epiglottis and lateral parts of the base of the tongue. The specimen is marked with a suture and sent for frozen section. In the frozen section from the cranial to the alveolar ridge still severe dysplasia, also from the alveolar ridge to the base of the tongue. In situ infiltrates and partly microinvasive carcinoma caudally in the area of the entrance to the piriform sinus. Several extensive resections are therefore performed. A resection includes mucosa and some underlying tissue from the uvula to the alveolar ridge, thickness at least 1-1.5 cm. All sutures remote from the tumor. Further resection from the lateral area of the alveolar ridge to the base of the tongue via the floor of the mouth, also approx. 1 cm thick, sutures also tumor-free. A further marginal sample from the border area to the tube in the nasopharynx. Another from the caudal base of the tongue. Another caudal marginal sample is taken from the lingual epiglottis via the vallecula to the arytenoid fold and the piriform sinus, which extends medially to the resection border on the posterior pharyngeal wall. Here too, the sutures are remote from the tumor, thickness a good cm. In the frozen section, all marginal samples without dysplasia or carcinoma. Hemostasis now follows. Irrigation. Measurement of the defect size. This is 13.5 x 7.5 cm, flap is planned according to the size and required three-dimensional defect coverage. Neck dissection on the right: skin incision as on the opposite side but more limited. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle, exposure of the digastric muscle. Subsequent evacuation level II-IV. Exposure of internal carotid artery, external carotid artery, superior thyroid artery, facial vein, internal jugular vein. Exposure and preservation of the hypoglossal nerve, vagus nerve, accessorius nerve. Levels II-IV are evacuated, preserving branches of the cervical plexus. Subsequent careful hemostasis and layered wound closure with insertion of a Redon drainage. Then elevation of the radial flap, surgeons: , : Marking of the flap in the appropriate size and three-dimensional orientation. Then elevate the flap first from ulnar, subfascial, then extend the incision cranially to the olecranon. Exposure of the superficial venous system. Exposure of the connection to the deep venous system. The superficial venous system is then elevated subfascially. The flap is now elevated from the radial, subfascial side. The lateral antebrachial cutaneous nerve is exposed and preserved as far as possible. The radial artery and radial vein are exposed caudally and initially clamped. Further elevation of the flap from lateral to medial. Lift the flap off the brachioradialis muscle. Further exposure of the superficial venous system. A venencephalica can be visualized medially and laterally. The radial artery is then cut and treated using 4-0 Prolene puncture ligatures. The flap is then removed subfascially. Outgoing vessels are clipped or treated using bipolar ligatures. Lifting of the flap cranially along the pedicle. Depiction of the interosseous artery, which is severed. Exposure of the entrance of the radial artery into the brachial artery. Depiction of confluence. Subsequent removal of the flap. The veins are ligated and the artery is supplied with Vascufil 6-0 puncture ligatures. The saturation in the hand area is always within the normal range until the end of flap elevation. After removal of the flap, it is flushed with heparin. The flap is then inserted into the defect. The flap is first sutured caudally, partly with the sutures in place. Subsequently, also partly with the sutures in place on the cranial side. Sufficient, tension-free defect coverage is achieved using the flap. The pedicle is inserted caudally into the soft tissues of the neck. The facial artery is selected and conditioned for the anastomosis. After conditioning the radial artery, suture using 8-0 Ethilon single-button sutures. After opening the clamp, good arterial pulse and flow, good venous return. Then, starting from the facial nerve, one vein is conditioned for the anastomosis with the cephalic vein and a smaller one for the anastomosis with the confluence. The second cephalic vein is partly unsuitable for anastomosis due to thickened walls, probably due to scarring after infusion; it is clipped later. The smaller outlet of the facial vein is anastomosed with the confluence using a 2-0 coupler. Positive smear phenomenon after opening the clamps, good venous flow. Another outlet is clipped here. The larger outlet of the facial vein is anastomosed with the cephalic vein after conditioning using a 3-0 coupler. Here too, good venous return after opening the clamp. Positive smear phenomenon. Small outlets are also clipped here. Final inspection of the flap, which is regular. A tracheal cannula is inserted and fixed with sutures. The procedure is then completed without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue the intraoperative antibiotic treatment with Unacid 3 g for one week. Please continue heparin perfusor 500 E/h for 5 days. Control of the flap according to the scheme clinically and by means of Doppler sonography for 5 days. Site for Doppler was thread-marked. Flap control clinically well possible. Feeding via the inserted PEG tube for 10 days, followed by gruel and, if necessary, diet build-up. Overall, at least cT3 oropharyngeal carcinoma cN1-cN2b. Waiting for the final histology and presentation or discussion in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/715/InvasionFront_CD3_block4_x5_y11_patient715_0.json b/715/InvasionFront_CD3_block4_x5_y11_patient715_0.json new file mode 100644 index 0000000000000000000000000000000000000000..58bef51c94848d5255ae990d6dc3cd683db64eae --- /dev/null +++ b/715/InvasionFront_CD3_block4_x5_y11_patient715_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 33807.1, + "Num Detections": 24288, + "Num Negative": 23507, + "Num Positive": 781, + "Positive %": 3.216, + "Num Positive per mm^2": 303.67 + } +} \ No newline at end of file diff --git a/715/InvasionFront_CD3_block4_x6_y11_patient715_1.json b/715/InvasionFront_CD3_block4_x6_y11_patient715_1.json new file mode 100644 index 0000000000000000000000000000000000000000..582393587ac6b9528c796e73c92a9b53fbe2f5f5 --- /dev/null +++ b/715/InvasionFront_CD3_block4_x6_y11_patient715_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21113.8, + "Centroid Y µm": 33832.1, + "Num Detections": 20847, + "Num Negative": 20201, + "Num Positive": 646, + "Positive %": 3.099, + "Num Positive per mm^2": 255.76 + } +} \ No newline at end of file diff --git a/715/InvasionFront_CD8_block4_x5_y11_patient715_0.json b/715/InvasionFront_CD8_block4_x5_y11_patient715_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6d8ea6c6972fce8076a0a69f0c932ff016a4ae20 --- /dev/null +++ b/715/InvasionFront_CD8_block4_x5_y11_patient715_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 32632.7, + "Num Detections": 25421, + "Num Negative": 24800, + "Num Positive": 621, + "Positive %": 2.443, + "Num Positive per mm^2": 236.29 + } +} \ No newline at end of file diff --git a/715/InvasionFront_CD8_block4_x6_y11_patient715_1.json b/715/InvasionFront_CD8_block4_x6_y11_patient715_1.json new file mode 100644 index 0000000000000000000000000000000000000000..72b479c82b570e80c845b454638e1ed5911e09d6 --- /dev/null +++ b/715/InvasionFront_CD8_block4_x6_y11_patient715_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 32682.7, + "Num Detections": 21541, + "Num Negative": 21047, + "Num Positive": 494, + "Positive %": 2.293, + "Num Positive per mm^2": 191.43 + } +} \ No newline at end of file diff --git a/715/TumorCenter_CD3_block4_x5_y11_patient715_0.json b/715/TumorCenter_CD3_block4_x5_y11_patient715_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8383b26572608050017bb799b5861fbbb2813ed7 --- /dev/null +++ b/715/TumorCenter_CD3_block4_x5_y11_patient715_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 28110.1, + "Num Detections": 20891, + "Num Negative": 20119, + "Num Positive": 772, + "Positive %": 3.695, + "Num Positive per mm^2": 299.67 + } +} \ No newline at end of file diff --git a/715/TumorCenter_CD3_block4_x6_y11_patient715_1.json b/715/TumorCenter_CD3_block4_x6_y11_patient715_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a8b95ae70be510bb6efded0bedffb516d1ee3a82 --- /dev/null +++ b/715/TumorCenter_CD3_block4_x6_y11_patient715_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 28060.1, + "Num Detections": 21752, + "Num Negative": 20018, + "Num Positive": 1734, + "Positive %": 7.972, + "Num Positive per mm^2": 759.31 + } +} \ No newline at end of file diff --git a/715/TumorCenter_CD8_block4_x5_y11_patient715_0.json b/715/TumorCenter_CD8_block4_x5_y11_patient715_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ca5431bb1f9d3cadf6314818dba7028ac2d3355d --- /dev/null +++ b/715/TumorCenter_CD8_block4_x5_y11_patient715_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 28385.0, + "Num Detections": 21124, + "Num Negative": 20781, + "Num Positive": 343, + "Positive %": 1.624, + "Num Positive per mm^2": 132.68 + } +} \ No newline at end of file diff --git a/715/TumorCenter_CD8_block4_x6_y11_patient715_1.json b/715/TumorCenter_CD8_block4_x6_y11_patient715_1.json new file mode 100644 index 0000000000000000000000000000000000000000..92b919b069db750355835ce7693c4a691f915a87 --- /dev/null +++ b/715/TumorCenter_CD8_block4_x6_y11_patient715_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 28484.9, + "Num Detections": 22694, + "Num Negative": 21602, + "Num Positive": 1092, + "Positive %": 4.812, + "Num Positive per mm^2": 470.11 + } +} \ No newline at end of file diff --git a/715/history_text.txt b/715/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..54eff1341b6b318359ef2f8573432efab7e4a7a7 --- /dev/null +++ b/715/history_text.txt @@ -0,0 +1 @@ +The patient had a clinical case of cN2b neck status on the right side with an approx. 3 cm large metastasis at the lower parotid pole and histologically confirmed evidence of a squamous cell carcinoma (gross needle biopsy). A PET-CT scan carried out beforehand showed a multiple enhancement in the area of the right base of the tongue. In addition, the FDG-PET also showed multiple enhancement in the area of the cervical lymph node metastasis on the right side and in the distal colon (colonoscopy recommended here). Based on the findings, the above-mentioned operation is indicated. \ No newline at end of file diff --git a/715/icd_codes.txt b/715/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b813f66c5435e143f5d136b34edada049e2145db --- /dev/null +++ b/715/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Seitenwand des Oropharynx[C10.2 R] \ No newline at end of file diff --git a/715/ops_codes.txt b/715/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..68d1fd82b9e6da5dd293f7a0900f7b0f0a0e9d54 --- /dev/null +++ b/715/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision Wange[5-273.4 R] Inzision erkranktes Gewebe Zungenrand[5-250.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/715/patient_clinical_data.json b/715/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..74dee634729cb998f3ad213b136037050c592004 --- /dev/null +++ b/715/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 58, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 9, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/715/patient_pathological_data.json b/715/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cbd2717b9bbfbbe0975a71ebfae9d9dfc2d96da5 --- /dev/null +++ b/715/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "715", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/715/surgery_description.txt b/715/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..79b50831a9e21e018f442601b197598e0abea050 --- /dev/null +++ b/715/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Left-sided neck dissection, Panendoscopy diff --git a/715/surgery_report.txt b/715/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4520e0de2e1d51022b6078d7f630939fc578ea61 --- /dev/null +++ b/715/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater. Active patient identification. Team time-out and initial consultation with anesthesia colleagues. Induction of anesthesia by the colleagues. 0° tracheoscopy by the surgeon: the trachea is free of irritation and inconspicuous on all sides, the trachea is visible up to the carina. Intubation of the patient by the anesthesia colleagues. Positioning of the patient in the head reclination position and insertion of the small bore tube size C. Inspection of the hypopharynx, first on the left, then on the right side. The piriform sinus must be freely unfolded on both sides and free of masses. Now adjust the endolarynx. Here also inconspicuous conditions. Withdrawal of the small aqueous humor tube and inspection of the epiglottis and vallecula. Here also inconspicuous conditions. Insertion of the mouth retractor and inspection of the oropharynx. In the area of the right base of the tongue, a cherry stone-sized mass measuring approx. 1 cm was found, which was palpable. The other regions of the oropharynx were unremarkable. Demonstration of the findings to and decision to perform an excisional biopsy or tumor resection. Incision of the mucosa with an electric needle. Dissection with scissors through the tongue muscles under constant palpatory control. Bipolar coagulation of individual vessels. It becomes apparent that the tumor extends to the glossotonsillar groove on the right side. Therefore, generous tumor resection also in the area of the glossotonsillar groove so that the parapharyngeal fatty tissue is exposed. Removal of the tumor with healthy marginal tissue without complications. In addition, a resection is made in the area of the glossotonsillar groove, as the resection was only just made here macroscopically. The specimen is sent for histological frozen section examination. Feedback from the pathologist at 12:30: Main tumor specimen with a squamous cell carcinoma (forming a margin to the glossotonsillar groove). In the resection in the area of the glossotonsillar groove, however, resected R0. Due to the deep resection down to the parapharyngeal fat on the right side, the planned neck dissection on the right was not performed. This should be performed twice in 3 weeks in order to avoid an extensive defect. The patient is now repositioned and the decision is made to perform the neck dissection on the left side. To do this, make a skin incision in the area of a skin fold along the sternocleidomastoid muscle. Cut through the cutaneous and subcutaneous tissue. Dissection of the platysma. Subplatysmal dissection cranially until the submandibular gland is exposed. Subplatysmal dissection caudally to expose the omohyoid muscle. Free preparation of the anterior border of the sternocleidomastoid muscle down to the depth. Identification of the accessor nerve and exposure of the nerve. This can be safely spared. Identification of the posterior venter of the digastric muscle. Division of the neck preparation in the medial and lateral part on the internal jugular vein. Reliable identification of the vagus nerve and the common carotid artery. Identification of the hypoglossal nerve. Now detach the neck preparation from cranial to caudal and pull through under the accessorius nerve. The neck preparation is carefully dissected from the deep cervical fascia. The branches of the cervical plexus can be safely spared. Check the wound again: dry wound conditions prevail everywhere. Irrigation with Ringer. Application of a Redon drainage and two-layer wound closure. Recheck of the enoral findings. There is no further bleeding enorally. The operation is completed without complications. \ No newline at end of file diff --git a/716/InvasionFront_CD8_block3_x1_y12_patient716_0.json b/716/InvasionFront_CD8_block3_x1_y12_patient716_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a3d313de1e0c625727c629ccb0adba6765b7e4ba --- /dev/null +++ b/716/InvasionFront_CD8_block3_x1_y12_patient716_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4965.5, + "Centroid Y µm": 29575.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/716/InvasionFront_CD8_block3_x2_y12_patient716_1.json b/716/InvasionFront_CD8_block3_x2_y12_patient716_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dec7b40598e8ae9bdbf69399553fa474ec8a2c72 --- /dev/null +++ b/716/InvasionFront_CD8_block3_x2_y12_patient716_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7537.4, + "Centroid Y µm": 29544.6, + "Num Detections": 12370, + "Num Negative": 12300, + "Num Positive": 70, + "Positive %": 0.5659, + "Num Positive per mm^2": 50.87 + } +} \ No newline at end of file diff --git a/716/TumorCenter_CD3_block3_x1_y12_patient716_0.json b/716/TumorCenter_CD3_block3_x1_y12_patient716_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1186d148fbbb0c57ddc4702e487a768f77396a09 --- /dev/null +++ b/716/TumorCenter_CD3_block3_x1_y12_patient716_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3198.3, + "Centroid Y µm": 35706.1, + "Num Detections": 20601, + "Num Negative": 20007, + "Num Positive": 594, + "Positive %": 2.883, + "Num Positive per mm^2": 249.87 + } +} \ No newline at end of file diff --git a/716/TumorCenter_CD3_block3_x2_y12_patient716_1.json b/716/TumorCenter_CD3_block3_x2_y12_patient716_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a20d1237e342ba6c5e2b5e5a3a0d3ebb4856b559 --- /dev/null +++ b/716/TumorCenter_CD3_block3_x2_y12_patient716_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5946.9, + "Centroid Y µm": 35781.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/716/TumorCenter_CD8_block3_x1_y12_patient716_0.json b/716/TumorCenter_CD8_block3_x1_y12_patient716_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9efd724b903718dd5a658002c38665fbdd642c79 --- /dev/null +++ b/716/TumorCenter_CD8_block3_x1_y12_patient716_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 29934.2, + "Num Detections": 19757, + "Num Negative": 19300, + "Num Positive": 457, + "Positive %": 2.313, + "Num Positive per mm^2": 195.4 + } +} \ No newline at end of file diff --git a/716/TumorCenter_CD8_block3_x2_y12_patient716_1.json b/716/TumorCenter_CD8_block3_x2_y12_patient716_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c897d2f8918aa5df111aa456d8fb44e1c9256884 --- /dev/null +++ b/716/TumorCenter_CD8_block3_x2_y12_patient716_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 30284.0, + "Num Detections": 16740, + "Num Negative": 16521, + "Num Positive": 219, + "Positive %": 1.308, + "Num Positive per mm^2": 110.26 + } +} \ No newline at end of file diff --git a/716/history_text.txt b/716/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/716/icd_codes.txt b/716/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/716/ops_codes.txt b/716/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/716/patient_clinical_data.json b/716/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6f08f743eae7a9008d5435116163afae8bf72554 --- /dev/null +++ b/716/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2005, + "age_at_initial_diagnosis": 43, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/716/patient_pathological_data.json b/716/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..571d070cead6366048c3341e58a8e075ec05740b --- /dev/null +++ b/716/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "716", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/716/surgery_description.txt b/716/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..95ec2f6dec0327766887519b25dce42532817084 --- /dev/null +++ b/716/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Endoral resection of tongue base, Bilateral neck dissection diff --git a/716/surgery_report.txt b/716/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/717/InvasionFront_CD3_block8_x1_y1_patient717_0.json b/717/InvasionFront_CD3_block8_x1_y1_patient717_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cb6a7bb883083f5c10f7caad209a2d2589ba01dc --- /dev/null +++ b/717/InvasionFront_CD3_block8_x1_y1_patient717_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 12843.2, + "Num Detections": 25637, + "Num Negative": 24738, + "Num Positive": 899, + "Positive %": 3.507, + "Num Positive per mm^2": 328.56 + } +} \ No newline at end of file diff --git a/717/InvasionFront_CD3_block8_x2_y1_patient717_1.json b/717/InvasionFront_CD3_block8_x2_y1_patient717_1.json new file mode 100644 index 0000000000000000000000000000000000000000..38c3483656f14d64c2f6a18012ef6a2fd2641467 --- /dev/null +++ b/717/InvasionFront_CD3_block8_x2_y1_patient717_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6149.5, + "Centroid Y µm": 12757.0, + "Num Detections": 24629, + "Num Negative": 23628, + "Num Positive": 1001, + "Positive %": 4.064, + "Num Positive per mm^2": 366.37 + } +} \ No newline at end of file diff --git a/717/InvasionFront_CD8_block8_x1_y1_patient717_0.json b/717/InvasionFront_CD8_block8_x1_y1_patient717_0.json new file mode 100644 index 0000000000000000000000000000000000000000..813d2e34cced93ce8bbec348c7089503d4fdbefc --- /dev/null +++ b/717/InvasionFront_CD8_block8_x1_y1_patient717_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5197.2, + "Centroid Y µm": 2323.8, + "Num Detections": 26119, + "Num Negative": 23307, + "Num Positive": 2812, + "Positive %": 10.77, + "Num Positive per mm^2": 1029.9 + } +} \ No newline at end of file diff --git a/717/InvasionFront_CD8_block8_x2_y1_patient717_1.json b/717/InvasionFront_CD8_block8_x2_y1_patient717_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9795a5cc5042cf7ab24b929298c1fd811448f667 --- /dev/null +++ b/717/InvasionFront_CD8_block8_x2_y1_patient717_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7596.0, + "Centroid Y µm": 2448.7, + "Num Detections": 23789, + "Num Negative": 21867, + "Num Positive": 1922, + "Positive %": 8.079, + "Num Positive per mm^2": 711.31 + } +} \ No newline at end of file diff --git a/717/TumorCenter_CD3_block8_x1_y1_patient717_0.json b/717/TumorCenter_CD3_block8_x1_y1_patient717_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f22578fb034a6ef57bf86383fae5c7457cfa09c2 --- /dev/null +++ b/717/TumorCenter_CD3_block8_x1_y1_patient717_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3223.3, + "Centroid Y µm": 4747.5, + "Num Detections": 26889, + "Num Negative": 25509, + "Num Positive": 1380, + "Positive %": 5.132, + "Num Positive per mm^2": 499.47 + } +} \ No newline at end of file diff --git a/717/TumorCenter_CD3_block8_x2_y1_patient717_1.json b/717/TumorCenter_CD3_block8_x2_y1_patient717_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f2d8cb8d47a5c25cefed3ce88374e943158a71f3 --- /dev/null +++ b/717/TumorCenter_CD3_block8_x2_y1_patient717_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5597.0, + "Centroid Y µm": 4347.7, + "Num Detections": 23212, + "Num Negative": 22094, + "Num Positive": 1118, + "Positive %": 4.816, + "Num Positive per mm^2": 433.49 + } +} \ No newline at end of file diff --git a/717/TumorCenter_CD8_block8_x1_y1_patient717_0.json b/717/TumorCenter_CD8_block8_x1_y1_patient717_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6a41d1fbb33cd2c222b87d7be2efc0c5ae277056 --- /dev/null +++ b/717/TumorCenter_CD8_block8_x1_y1_patient717_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3373.2, + "Centroid Y µm": 4097.8, + "Num Detections": 29016, + "Num Negative": 28203, + "Num Positive": 813, + "Positive %": 2.802, + "Num Positive per mm^2": 285.46 + } +} \ No newline at end of file diff --git a/717/TumorCenter_CD8_block8_x2_y1_patient717_1.json b/717/TumorCenter_CD8_block8_x2_y1_patient717_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b61e7821210e9999191a398ee64f671aa879a456 --- /dev/null +++ b/717/TumorCenter_CD8_block8_x2_y1_patient717_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5871.9, + "Centroid Y µm": 3723.0, + "Num Detections": 25748, + "Num Negative": 24895, + "Num Positive": 853, + "Positive %": 3.313, + "Num Positive per mm^2": 319.8 + } +} \ No newline at end of file diff --git a/717/history_text.txt b/717/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..17f28cd4e97637574d6471a633d39391989299d1 --- /dev/null +++ b/717/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 cN3 cM0 G3 oropharyngeal carcinoma on the right was histologically confirmed as part of a panendoscopy. Due to the extensive metastasis, the CT scan showed the internal carotid artery to be displaced over a long distance, and an occlusion test was carried out preoperatively if there was no reliable sonographic infiltration. This revealed no discernible infiltration of the right internal carotid artery and normal occlusion with good collateralization. In our interdisciplinary tumor conference, primary surgical treatment was indicated. \ No newline at end of file diff --git a/717/icd_codes.txt b/717/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/717/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/717/ops_codes.txt b/717/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..71745946fa3a6b8c4f2d46169de441af2680287b --- /dev/null +++ b/717/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx ohne Rekonstruktion[5-296.00 ] Totale Laserresektion Zunge transoral sonstige[5-252.0x ] Endoskopische Laserresektion am Larynx[5-302.5 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 R] Partielle Parotidektomie ohne Fazialismonitoring[5-262.00 R] Diagnostische Ösophagogastroskopie[1-631 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] \ No newline at end of file diff --git a/717/patient_clinical_data.json b/717/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cc45b80b7a6f833fe5ab2fb1a7a1f544a1847855 --- /dev/null +++ b/717/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/717/patient_pathological_data.json b/717/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5e664420bd4592490e97c264533ae4e8a16ee4e8 --- /dev/null +++ b/717/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "717", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Lymphoepithelial", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/717/surgery_description.txt b/717/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..31f532299c733f03f569245400aa4018f7ca79cd --- /dev/null +++ b/717/surgery_description.txt @@ -0,0 +1 @@ +Transoral laser resection, Bilateral neck dissection, Partial right parotidectomy, Tracheostomy, PEG placement diff --git a/717/surgery_report.txt b/717/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9ea28f06a524145413c0e5cdf6750e6132839482 --- /dev/null +++ b/717/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesia colleagues and anesthesia preparation, re-evaluation of the primary tumor. Entry with the Kleinsasser tube. As described above, the exophytic tumor can be seen starting caudal to the right tonsillar lobe, extending laterally caudally over the lateral wall of the oropharynx and anteriorly towards the base of the tongue over the pharyngoepiglottic fold, also reaching the lateral epiglottis. In addition, the right-sided vallecula is clearly infiltrated. Palpatory superficial tumor growth, as well as tumor extension at the lateral place of the aryepiglottic fold. Overall just T2. Due to the good displaceability and lack of signs of growth per continuitatem, laser resection was confirmed. The tumor can be completely removed macroscopically with the CO2 laser at a power of 2-8 watts. Resection with caudal tonsil ligament, pharyngeal side wall, right-sided superficial removal of the base of the tongue, removal of the right vallecula and, in the case of somewhat edematous epiglottis and questionable infiltration, removal of the narrow strip of the epiglottis with cartilage. The right aryepiglottic fold must also be resected. The tumor ends in front of the entrance to the right piriform sinus. No further extension into the hypopharynx. Macroscopically complete removal in depth, safe conditions on all sides. ................ Resections in soft tissue of the neck or no evidence of exposed fatty tissue. This is followed by complete coverage of the entire tumor by means of marginal samples, which are completely tumor-free; only in the area of the lingual epiglottis are there markedly inflammatory infiltrates with no further possibility of differentiation, but the possibility of residual tumor cells, which is why a resection and a final marginal sample are performed here, which is again diagnosed as completely tumor-free in the frozen section diagnostics. Endoscopic PEG placement had already been performed previously. This was done using a gastroscope under laryngoscopic control. Easy to see through to the stomach. Excellent diaphanoscopy. Problem-free puncture of the stomach and subsequent positioning of the PEG tube using the usual suture pull-through method. The plastic tracheostomy was performed in the meantime. This involved a horizontal skin incision at the level of the cricoid cartilage, cutting through the skin and subcutaneous tissue, exposing the infrahyoid muscles, entering the linea alba, exposing the cricoid cartilage, exposing the anterior surface of the trachea. Insertion between the 1st and 2nd tracheal ring, creation of a broad-based pedicled Björk flap and insertion of the tracheostoma. Subsequently, problem-free reintubation to a size 8 low cuff cannula. After injection of xylocaine with adrenaline, functional neck dissection is now performed, initially starting with the right side. Here there is an extensive coarse mass measuring well over 10 cm in all dimensions from the caudal parotid gland to region IV with extensive infiltration towards the paravertebral musculature. Skin incision around the lobule over the mastoid, curved towards the cervical in a typical shape. Cut through skin and subcutaneous tissue. Dissection of the skin mantle, this is not infiltrated at any point, the platysma is largely left on the metastasis to leave a layer. Release of the lobule, exposure of the anterior wall of the auditory canal, exposure of the parotid capsule. Exposure of the sternocleidomastoid muscle, which is extensively infiltrated. Exposure of the omohyoid muscle. Caudal exposure of the sternocleidomastoid muscle. Exposure of the infiltrated internal jugular vein caudally. Separation of the common carotid artery and the vagus nerve. Detachment of the metastasis caudally, including up to level Vb, here at least one further highly suspicious mass measuring approx. 3 cm, otherwise several macroscopically not necessarily conspicuous lymph nodes. Resection up to the brachial plexus, but this itself remains covered. The cervical plexus is resected subtotally. The auricularis magnus nerve could be dissected away from the mass beforehand and remains intact for subsequent splinting if necessary. Exposure of the submandibular gland and the anterior digstricus muscle. Dissection shows that the submandibular gland is also infiltrated dorso-caudally. The digastric muscle is long and extensively infiltrated, with the mass extending to the mandible. This is followed by release of the submandibular gland and ligation of the facial artery. Exposure of the common carotid artery and the bulb, exposure and release of the internal carotid artery and the vagus nerve, which can remain completely intact. Also in the area of the entire common carotid artery and the internal carotid artery .............. Adeventitia. Dissection of the external carotid artery, ligation of the superior thyroid artery. The external carotid artery is infiltrated in the canal and is later removed. Exposure of the infiltrated hypoglossal nerve. This is also removed. Exposure and preservation of the lingual nerve. The mass reaches around the mandible, infiltrating it, but certainly not the periosteum. There is also no infiltration of the floor of the mouth, but large parts of the floor of the mouth muscles are involved. It can now be seen that the mass clearly extends into the parotid gland. The decision was therefore made to expose the main trunk. Exposure of the pointer. Release of the mastoid here close to the attachment. Infiltration of the digastric muscle, exposure of the main trunk, which is clearly displaced here but not infiltrated, the mass can be completely removed from the parotid gland by extubation of the caudal parotid gland with resection of only the most caudal branch of the mouth. Overall significant displacement of the facial nerve in the course of the procedure with possibly protracted recovery. Exposure and release of the mastoid, involvement of large parts of the scalene muscles. The phrenic nerve can be preserved. Removal of a muscle sheath on all sides and resection of the metastasis macroscopically in toto, even after final examination, no margin-forming areas, a small tumor cone was resected separately in the area of the floor of the mouth so that a complete in sano resection was performed. Finally, completion of level Ib, with several macroscopic nodules. After multiple careful wound inspections and wound irrigation, careful control of the pharyngeal area, where no patency to the primary tumor area could be probed or visualized, so that 2 Redondra rings were inserted and the subsequent .............. wound closure. Carry out the neck dissection on the left side. To do this, make a house incision on the front edge of the sternocleidomastoid muscle and cut through the skin and subcutaneous tissue. Exposure and dissection of the platysma. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digasatric muscle. There are several nodules up to 2 cm in the area of the vein course and in the area of the jugulo-facial angle, but macroscopically not necessarily suspicious. Dissection of the internal jugular vein and preservation of the facial vein, the superior thyroid artery and the hypoglossal nerve. Exposure of the accessorius nerve, clearing of the accessorius triangle and completion of levels III and IV with careful protection of the cervical plexus branches. Subsequent inspection of the wound area and, if the wound is dry, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Final enoral inspection and, if the wound is dry, termination of the procedure at this point. Several intraoperative discussions of the findings and case were held with . The patient received intravenous antibiotics with Unacid 3 g, to be continued for 24 hours postoperatively. Conclusion: Transoral laser resected, intraoperative cT2 cN3 R0 oropharyngeal carcinoma on the right with extended radical neck dissection and resection of the cervical plexus of the hypoglossal nerve and the caudal parotid gland. Adjuvant radiochemotherapy appears to be absolutely necessary here. Please initially feed for 7 days via the inserted PEG tube, followed by a clinical swallowing trial. Due to the resection area of the primary tumour site and the extensive extended radical neck dissection, a protracted recovery of swallowing function is to be expected here. \ No newline at end of file diff --git a/718/InvasionFront_CD3_block17_x1_y2_patient718_0.json b/718/InvasionFront_CD3_block17_x1_y2_patient718_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3a3e0cb8e0fb4f841f1505face7ec440ba6bdc0c --- /dev/null +++ b/718/InvasionFront_CD3_block17_x1_y2_patient718_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 9994.7, + "Num Detections": 24569, + "Num Negative": 22864, + "Num Positive": 1705, + "Positive %": 6.94, + "Num Positive per mm^2": 638.79 + } +} \ No newline at end of file diff --git a/718/InvasionFront_CD3_block17_x2_y2_patient718_1.json b/718/InvasionFront_CD3_block17_x2_y2_patient718_1.json new file mode 100644 index 0000000000000000000000000000000000000000..157cb33d6b36e7ce5d3b82f66b568b684dda3d12 --- /dev/null +++ b/718/InvasionFront_CD3_block17_x2_y2_patient718_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 10069.7, + "Num Detections": 22601, + "Num Negative": 21015, + "Num Positive": 1586, + "Positive %": 7.017, + "Num Positive per mm^2": 623.02 + } +} \ No newline at end of file diff --git a/718/InvasionFront_CD8_block17_x1_y2_patient718_0.json b/718/InvasionFront_CD8_block17_x1_y2_patient718_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bf7f6e04f1266117e8aa2a757acd7ebd29a07b7d --- /dev/null +++ b/718/InvasionFront_CD8_block17_x1_y2_patient718_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4272.7, + "Centroid Y µm": 5447.1, + "Num Detections": 22271, + "Num Negative": 21487, + "Num Positive": 784, + "Positive %": 3.52, + "Num Positive per mm^2": 306.16 + } +} \ No newline at end of file diff --git a/718/InvasionFront_CD8_block17_x2_y2_patient718_1.json b/718/InvasionFront_CD8_block17_x2_y2_patient718_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e3bba310ff703ac9f7c6ff01b42a0ddb541e72b --- /dev/null +++ b/718/InvasionFront_CD8_block17_x2_y2_patient718_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 5447.1, + "Num Detections": 22640, + "Num Negative": 21828, + "Num Positive": 812, + "Positive %": 3.587, + "Num Positive per mm^2": 328.97 + } +} \ No newline at end of file diff --git a/718/TumorCenter_CD3_block17_x1_y2_patient718_0.json b/718/TumorCenter_CD3_block17_x1_y2_patient718_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c2dfc53064e0d9d1bf4047018cd3221ffb54e5e3 --- /dev/null +++ b/718/TumorCenter_CD3_block17_x1_y2_patient718_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 5172.3, + "Num Detections": 24574, + "Num Negative": 20927, + "Num Positive": 3647, + "Positive %": 14.84, + "Num Positive per mm^2": 1383.1 + } +} \ No newline at end of file diff --git a/718/TumorCenter_CD3_block17_x2_y2_patient718_1.json b/718/TumorCenter_CD3_block17_x2_y2_patient718_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aed909b067ffeab4de003739fa926c9f8d9f559a --- /dev/null +++ b/718/TumorCenter_CD3_block17_x2_y2_patient718_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6171.7, + "Centroid Y µm": 5147.3, + "Num Detections": 24000, + "Num Negative": 18579, + "Num Positive": 5421, + "Positive %": 22.59, + "Num Positive per mm^2": 1982.9 + } +} \ No newline at end of file diff --git a/718/TumorCenter_CD8_block17_x1_y2_patient718_0.json b/718/TumorCenter_CD8_block17_x1_y2_patient718_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bcb6479f943e7dd59b3cb72c6b828b058ed1d2f9 --- /dev/null +++ b/718/TumorCenter_CD8_block17_x1_y2_patient718_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6319.1, + "Centroid Y µm": 18994.3, + "Num Detections": 23064, + "Num Negative": 21725, + "Num Positive": 1339, + "Positive %": 5.806, + "Num Positive per mm^2": 521.55 + } +} \ No newline at end of file diff --git a/718/TumorCenter_CD8_block17_x2_y2_patient718_1.json b/718/TumorCenter_CD8_block17_x2_y2_patient718_1.json new file mode 100644 index 0000000000000000000000000000000000000000..23b26873f2b53153bb802303a18a348abccf3639 --- /dev/null +++ b/718/TumorCenter_CD8_block17_x2_y2_patient718_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8870.9, + "Centroid Y µm": 18906.3, + "Num Detections": 23384, + "Num Negative": 17967, + "Num Positive": 5417, + "Positive %": 23.17, + "Num Positive per mm^2": 2059.7 + } +} \ No newline at end of file diff --git a/718/history_text.txt b/718/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4735c8e87678585883980e06bd03d869cc3b95fc --- /dev/null +++ b/718/history_text.txt @@ -0,0 +1 @@ +In the patient, a T1 glottic carcinoma on the right <2019> was histologically confirmed; after presentation of the case in the interdisciplinary tumor conference, there is now an indication for surgical treatment. \ No newline at end of file diff --git a/718/icd_codes.txt b/718/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..72963d395e983f214cff7afcb40eb11de0f4ec77 --- /dev/null +++ b/718/icd_codes.txt @@ -0,0 +1 @@ +Sonstige Krankheiten der Stimmlippen[J38.3 ] Stimmlippenkarzinom[C32.0 R] \ No newline at end of file diff --git a/718/ops_codes.txt b/718/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f695680642f0e75f8cee9dfa09809542124c6abe --- /dev/null +++ b/718/ops_codes.txt @@ -0,0 +1 @@ +Laserresektion Larynxgewebe mit Stützlaryngoskopie[5-302.5 ] Mikrolaryngoskopie mit Resektion eines Larynxtumors[5-300.2 ] \ No newline at end of file diff --git a/718/patient_clinical_data.json b/718/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fc8194d2cad75a6d6442aebda676a44852c52950 --- /dev/null +++ b/718/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/718/patient_pathological_data.json b/718/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f9bcdce65c9388900644e1284b1951180763f40e --- /dev/null +++ b/718/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "718", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/718/surgery_description.txt b/718/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..95d1f03115376ebbfb10adc88a6af28691e593a8 --- /dev/null +++ b/718/surgery_description.txt @@ -0,0 +1 @@ +Transoral laser resection, Microlaryngoscopy diff --git a/718/surgery_report.txt b/718/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d42a4cf75ef378a3d9ff935cd33125f37bdce6f5 --- /dev/null +++ b/718/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia by the anesthesia colleagues, transoral intubation using a laser tube, head positioning and insertion with the size C small bore tube after insertion of a maxillary tooth guard. Adjustment of the glottic plane, overall positioning is limited, but the overview in the area of the anterior commissure is ultimately possible thanks to external counterpressure. Demonstration of findings to , decision to perform transoral laser resection by . Now determination of the resection limits, anterior resection up to the anterior commissure, posterior resection of the vocal process of the arytenoid cartilage on the right, the tumor itself has an extension of approx. 0.5 x 0.5 cm and is located in the posterior to middle third of the right vocal fold. The surrounding tissue appears altered in the sense of chronic hyperplastic laryngitis, making it difficult to differentiate between the mucosa and the tumor, even under the microscope. Laser resection is now performed by and alternately, the tumor is resected in toto and macroscopically in sano. A large posterior margin specimen and a supraglottic and anterior margin specimen are then taken in the area of the midline of the anterior commissure, the margin specimens are sent for frozen section examination, the main specimen is sent for histological processing marked with a thread. Hemostasis is then achieved by monopolar coagulation and application of suprarenin-soaked swabs. The frozen section still shows carcinoma in situ in the area of the anterior cranial margin sample, so a laser resection is performed here and the resected specimen is sent for final histological processing. Subsequent resection of margin samples, which are tumor-free in the frozen section, thus intraoperative R0 resection. Hemostasis again. Removal of all foreign material. Removal of the head position and completion of the procedure without any indication of complications. Conclusion: Transoral laser resection of a cT1a vocal fold carcinoma occupying the right vocal fold, intraoperatively R0 in the frozen section. Please note the final histology and plan a follow-up MLE in approx. 8 weeks. \ No newline at end of file diff --git a/719/InvasionFront_CD3_block18_x3_y8_patient719_0.json b/719/InvasionFront_CD3_block18_x3_y8_patient719_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b5033b3d547ab0db68b24cd245e7dd34ab4d561 --- /dev/null +++ b/719/InvasionFront_CD3_block18_x3_y8_patient719_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 25011.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/719/InvasionFront_CD3_block18_x4_y8_patient719_1.json b/719/InvasionFront_CD3_block18_x4_y8_patient719_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5736f746e3c9258168d926ce02ddeaac3f8f1a84 --- /dev/null +++ b/719/InvasionFront_CD3_block18_x4_y8_patient719_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 24587.0, + "Num Detections": 9062, + "Num Negative": 8957, + "Num Positive": 105, + "Positive %": 1.159, + "Num Positive per mm^2": 93.53 + } +} \ No newline at end of file diff --git a/719/InvasionFront_CD8_block18_x3_y8_patient719_0.json b/719/InvasionFront_CD8_block18_x3_y8_patient719_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c8a20a03ef482cfc6c1e1e57e6a3bf953dc619bc --- /dev/null +++ b/719/InvasionFront_CD8_block18_x3_y8_patient719_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11319.0, + "Centroid Y µm": 27535.4, + "Num Detections": 13856, + "Num Negative": 13824, + "Num Positive": 32, + "Positive %": 0.2309, + "Num Positive per mm^2": 21.84 + } +} \ No newline at end of file diff --git a/719/InvasionFront_CD8_block18_x4_y8_patient719_1.json b/719/InvasionFront_CD8_block18_x4_y8_patient719_1.json new file mode 100644 index 0000000000000000000000000000000000000000..024147169e19ed1853783420c18be092f431592a --- /dev/null +++ b/719/InvasionFront_CD8_block18_x4_y8_patient719_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 27635.4, + "Num Detections": 15333, + "Num Negative": 15316, + "Num Positive": 17, + "Positive %": 0.1109, + "Num Positive per mm^2": 10.37 + } +} \ No newline at end of file diff --git a/719/TumorCenter_CD3_block18_x3_y8_patient719_0.json b/719/TumorCenter_CD3_block18_x3_y8_patient719_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d51ffccb008119c7c5af0742bf989d9bce525d22 --- /dev/null +++ b/719/TumorCenter_CD3_block18_x3_y8_patient719_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10557.9, + "Centroid Y µm": 19465.7, + "Num Detections": 13202, + "Num Negative": 11703, + "Num Positive": 1499, + "Positive %": 11.35, + "Num Positive per mm^2": 826.62 + } +} \ No newline at end of file diff --git a/719/TumorCenter_CD3_block18_x4_y8_patient719_1.json b/719/TumorCenter_CD3_block18_x4_y8_patient719_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7a57900c37aae31e86ec49b29c8affb0a965e73e --- /dev/null +++ b/719/TumorCenter_CD3_block18_x4_y8_patient719_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13173.2, + "Centroid Y µm": 19461.6, + "Num Detections": 15473, + "Num Negative": 14886, + "Num Positive": 587, + "Positive %": 3.794, + "Num Positive per mm^2": 278.93 + } +} \ No newline at end of file diff --git a/719/TumorCenter_CD8_block18_x3_y8_patient719_0.json b/719/TumorCenter_CD8_block18_x3_y8_patient719_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dc7847ac29a8e80edd4da962230b42f5281ff451 --- /dev/null +++ b/719/TumorCenter_CD8_block18_x3_y8_patient719_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10469.5, + "Centroid Y µm": 20414.2, + "Num Detections": 16696, + "Num Negative": 15252, + "Num Positive": 1444, + "Positive %": 8.649, + "Num Positive per mm^2": 707.06 + } +} \ No newline at end of file diff --git a/719/TumorCenter_CD8_block18_x4_y8_patient719_1.json b/719/TumorCenter_CD8_block18_x4_y8_patient719_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cfdce197c168ca80a68533f729de77b23d00bd36 --- /dev/null +++ b/719/TumorCenter_CD8_block18_x4_y8_patient719_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13118.1, + "Centroid Y µm": 20539.1, + "Num Detections": 10933, + "Num Negative": 10610, + "Num Positive": 323, + "Positive %": 2.954, + "Num Positive per mm^2": 233.68 + } +} \ No newline at end of file diff --git a/719/history_text.txt b/719/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/719/icd_codes.txt b/719/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2508fd96c85f687daa2a5e3bab2031092ac465a7 --- /dev/null +++ b/719/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/719/ops_codes.txt b/719/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..84fd7f2efa734ae005f1de42a20a369a7396c426 --- /dev/null +++ b/719/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie endoskopische Laserresektion[5-302.5 ] \ No newline at end of file diff --git a/719/patient_clinical_data.json b/719/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c400467da6ecaa79ae352d3e91412a0ca8fcd594 --- /dev/null +++ b/719/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 8, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/719/patient_pathological_data.json b/719/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1deae809a94f4eb6fdcf1219fdea369f46e3c49a --- /dev/null +++ b/719/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "719", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/719/surgery_description.txt b/719/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1a01e54280007300ce90f3cdf41c8a8dfee74c8b --- /dev/null +++ b/719/surgery_description.txt @@ -0,0 +1 @@ +Transoral laser surgical tumor resection diff --git a/719/surgery_report.txt b/719/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e68c50eee06cdd0bd23b409aee46de10d7a395a5 --- /dev/null +++ b/719/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first adjust the glottic plane with a YES tube so that the anterior commissure can also be seen from the outside by applying pressure to the larynx. This is only affected on the left side with a CIS. The tumor extension is made more difficult by the slightly overhanging supraglottis, so that a narrow strip of supraglottis is first removed by laser surgery. The tumor is then resected starting at the anterior commissure. The periosteum is exposed at the front and the altered vocal fold area is detached in a healthy layer. Extend the laser resection laterally as far as necessary so that healthy tissue can always be prepared or resected by laser surgery. The first part of the tumor covers the anterior third of the right vocal fold. In this way, the tumor is successively resected from its lateral attachment site so that it is mobile enough to also overlook the caudal part and then resected with an appropriate safety margin. Subsequently, marginal incisions are made supraglottically, subglottically and in the area of the anterior commissure. In the area of the anterior commissure, the tissue is unrepresentative or severely thermally altered. However, resection at this site shows no evidence of tumor. The tumor is then further developed dorsally. To do this, switch to the Kleinsasser B-tube. This time the resection extends to the vocal process, which is also partially removed. Here too, marginal sections are first taken from the resection margin, all of which prove to be free of tumor on frozen section histology. The remaining tumor parts on the arytenoid cartilage are then resected with an appropriate safety margin. The tube is repeatedly loaded onto the Kleinsasser B or C tube so that the tumor can also be resected medially in the area of the posterior commissure with an appropriate safety margin. In this way, tumor resection with partial removal of the right arytenoid cartilage is ultimately successful. The marginal incisions from this area also proved to be tumor-free on frozen section histology. In summary, an R0 resection can therefore be assumed. Finally, careful hemostasis by monopolar coagulation. Removal of the instruments without tooth damage and transfer of the patient to anesthesia. Conclusion: Transoral laser-surgical partial laryngeal resection for right cT2 glottic laryngeal carcinoma. All incisions were tumor-free on frozen section histology. Control panendoscopy in 8 weeks. \ No newline at end of file diff --git a/720/InvasionFront_CD3_block9_x1_y1_patient720_0.json b/720/InvasionFront_CD3_block9_x1_y1_patient720_0.json new file mode 100644 index 0000000000000000000000000000000000000000..abb886ac65666c7f66e3561f402527bb7f73b4de --- /dev/null +++ b/720/InvasionFront_CD3_block9_x1_y1_patient720_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 2723.6, + "Num Detections": 23099, + "Num Negative": 21701, + "Num Positive": 1398, + "Positive %": 6.052, + "Num Positive per mm^2": 563.13 + } +} \ No newline at end of file diff --git a/720/InvasionFront_CD3_block9_x2_y1_patient720_1.json b/720/InvasionFront_CD3_block9_x2_y1_patient720_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf0b73ac4935f9ecf22b4df40e45cef64833b835 --- /dev/null +++ b/720/InvasionFront_CD3_block9_x2_y1_patient720_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8995.2, + "Centroid Y µm": 2773.5, + "Num Detections": 19457, + "Num Negative": 18504, + "Num Positive": 953, + "Positive %": 4.898, + "Num Positive per mm^2": 421.4 + } +} \ No newline at end of file diff --git a/720/InvasionFront_CD8_block9_x1_y1_patient720_0.json b/720/InvasionFront_CD8_block9_x1_y1_patient720_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d89b70e2cdc33de84e6c9cfe9eda161109ca71e --- /dev/null +++ b/720/InvasionFront_CD8_block9_x1_y1_patient720_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 7071.3, + "Num Detections": 22775, + "Num Negative": 21391, + "Num Positive": 1384, + "Positive %": 6.077, + "Num Positive per mm^2": 582.37 + } +} \ No newline at end of file diff --git a/720/InvasionFront_CD8_block9_x2_y1_patient720_1.json b/720/InvasionFront_CD8_block9_x2_y1_patient720_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a102dcc32a2a29e218b3064c04def9479daa02b6 --- /dev/null +++ b/720/InvasionFront_CD8_block9_x2_y1_patient720_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8495.5, + "Centroid Y µm": 7421.1, + "Num Detections": 20284, + "Num Negative": 18524, + "Num Positive": 1760, + "Positive %": 8.677, + "Num Positive per mm^2": 805.38 + } +} \ No newline at end of file diff --git a/720/TumorCenter_CD3_block9_x1_y1_patient720_0.json b/720/TumorCenter_CD3_block9_x1_y1_patient720_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ef1d4526de335924a5c5477a74bfa3babd872d56 --- /dev/null +++ b/720/TumorCenter_CD3_block9_x1_y1_patient720_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4572.6, + "Centroid Y µm": 8195.7, + "Num Detections": 20792, + "Num Negative": 18895, + "Num Positive": 1897, + "Positive %": 9.124, + "Num Positive per mm^2": 804.7 + } +} \ No newline at end of file diff --git a/720/TumorCenter_CD3_block9_x2_y1_patient720_1.json b/720/TumorCenter_CD3_block9_x2_y1_patient720_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f80d76149ad70f9f2cca1440a5b35f53c8ac9346 --- /dev/null +++ b/720/TumorCenter_CD3_block9_x2_y1_patient720_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7121.2, + "Centroid Y µm": 8195.7, + "Num Detections": 18732, + "Num Negative": 16874, + "Num Positive": 1858, + "Positive %": 9.919, + "Num Positive per mm^2": 811.47 + } +} \ No newline at end of file diff --git a/720/TumorCenter_CD8_block9_x1_y1_patient720_0.json b/720/TumorCenter_CD8_block9_x1_y1_patient720_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bb636fee0fa529c437e8454e33ae840c2e781421 --- /dev/null +++ b/720/TumorCenter_CD8_block9_x1_y1_patient720_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3398.2, + "Centroid Y µm": 3773.0, + "Num Detections": 21110, + "Num Negative": 19312, + "Num Positive": 1798, + "Positive %": 8.517, + "Num Positive per mm^2": 756.06 + } +} \ No newline at end of file diff --git a/720/TumorCenter_CD8_block9_x2_y1_patient720_1.json b/720/TumorCenter_CD8_block9_x2_y1_patient720_1.json new file mode 100644 index 0000000000000000000000000000000000000000..04662f9b0d92f7cea3af78770b348e0e08c0569d --- /dev/null +++ b/720/TumorCenter_CD8_block9_x2_y1_patient720_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5971.8, + "Centroid Y µm": 3473.2, + "Num Detections": 18297, + "Num Negative": 16439, + "Num Positive": 1858, + "Positive %": 10.15, + "Num Positive per mm^2": 812.26 + } +} \ No newline at end of file diff --git a/720/history_text.txt b/720/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d00986b41e59833c198880942ebc7b2e0203a8d --- /dev/null +++ b/720/history_text.txt @@ -0,0 +1 @@ +Patient with post-panendoscopy and histologic confirmation of a carcinoma of the palatal arch/oropharynx. It is a squamous cell carcinoma. The above-mentioned operation is now indicated. \ No newline at end of file diff --git a/720/icd_codes.txt b/720/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc812a96bf6c5b11e6e0b30f5050412ad9dba306 --- /dev/null +++ b/720/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Gaumen, mehrere Teilbereiche überlappend[C05.8 ] \ No newline at end of file diff --git a/720/ops_codes.txt b/720/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f850e07256d362a3178dde763b5af99a7e27802a --- /dev/null +++ b/720/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Vollhaut Entnahmestelle Leisten- und Genitalregion[5-901.1c ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Permanente Tracheotomie[5-312.0 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/720/patient_clinical_data.json b/720/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9280de6f17e4c23d86ab4eece31488d621b57784 --- /dev/null +++ b/720/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 61, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 54, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/720/patient_pathological_data.json b/720/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5de195147a3593de6a77c5e4cf7fb20d4084c0da --- /dev/null +++ b/720/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "720", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/720/surgery_description.txt b/720/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a1c65c8aad637b3ef60cc31577e41fb32e3ba49 --- /dev/null +++ b/720/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, and Tracheotomy diff --git a/720/surgery_report.txt b/720/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..72772e20d2225918ba7699d7c13e1e09ceb3ef8d --- /dev/null +++ b/720/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy to confirm extension: The exophytic tumor is seen, which extends from one tonsil lobe on the left to the other and also grows posteriorly towards the nasopharynx. Now transoral resection: The tumor is removed macroscopically on all sides with a safety margin of approx. 1.5 cm in healthy tissue. The entire tonsil lobe on the left, the entire palatal arch up to the hard palate or the beginning of the vomer and the entire tonsil lobe on the right as well as on the left side up to the base of the tongue are removed. The tumor is resected macroscopically on all sides in healthy tissue. Suture marking. This is followed in the middle of the palatal arch in the direction of the vomer by a marginal sample with mucosa and soft tissue. This is also thread-marked for frozen section diagnostics. The tumor on the left caudal side, below the tonsil pole in the direction of the base of the tongue is not yet healthy, otherwise healthy on all sides, and the marginal sample is also healthy. Therefore, another extensive resection is performed in the area of the posterior palatal arch in the caudal region, the anterior palatal arch and parts of the base of the tongue. Subsequently, a marginal sample is taken from the area mentioned, which is thread-marked and sent for frozen section. No more tumor infiltrates here. Thus overall R0 status. This is followed by repositioning for neck dissection and defect coverage using a radial flap. Sterile covering of all areas. Start with neck dissection on both sides (): Start with neck dissection on the right side: mark a curved skin incision along the sternocleidomastoid muscle on the right side, then dissect through the subcutaneous tissue, initially sparing the external jugular vein, exposing the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland. Finding the digastric muscle and following it to the mastoid. Visualization of the hypoglossal nerve. Then locate the accessorius nerve, which is spared. Finally, the internal jugular vein and the facial vein are dissected in their course. Now develop the lateral neck preparation from level IIb to IV while sparing the cervical plexus and exposing the carotid artery and vagus nerve. All structures can be spared. Now follow the cervical artery and develop the anterior neck preparation while sparing all vascular structures. Finally, careful hemostasis and wound irrigation and then proceed to the creation of a plastic tracheostomy. Marking of a skin incision below the cricoid cartilage. Dissection through the subcutaneous tissue, ligation of two larger veins matching the anterior jugular vein, then separation of the infrahyoid musculature. Exposure of the cricoid cartilage and undermining of the thyroid isthmus which is ligated on both sides. Now expose the anterior tracheal wall and incision in the 3rd cartilage interspace while sparing the cuff. Finally, creation of a classic Bjlörk flap and epithelialization of the tracheostoma with single-button sutures, which is completely tension-free. Now reintubation. Then proceed to neck dissection on the left side. In principle the same procedure as on the right side, exposing the anterior border of the sternocleidomastoid muscle. Trace the omohyoid muscle. Expose the glanular submandibular muscle which is retracted. Now expose the hypoglossal nerve and follow the digastric muscle. Dissection of the internal jugular vein and exposure of the accessory nerve, which is spared. Now also develop the lateral neck preparation from level IIb to IV. Then follow the cervical artery and develop the anterior neck preparation while sparing all neurovascular structures. Here too, hemostasis using bipolar coagulation and wound irrigation. We now move on to the microvascular anatomy on the right side of the neck. Elevation of the radialis flap from the left forearm: After measuring the defect enorally, the flap is 13 cm long and a maximum width of 6 cm. The flap is first incised from the ulnar side. A curved incision is then made in the crook of the elbow. Exposure of the superficial venous system. Subfascial elevation of the flap from the ulnar side. Exposure of the vascular pedicle. Exposure distal to the radial artery. This is clamped. Lift the flap subfascially from the radial side. The flap remains at 100% for 10-15 minutes after the radial artery has been clamped. The radial artery is then removed. Treatment with puncture ligatures 4.0 Prolene. Then lift the flap along the pedicle. Outgoing smaller vessels are coagulated bipolar or treated with clips. Lift the flap with the vascular pedicle and superficial venous system into the crook of the elbow. A double outlet of the cephalic vein, a connection to the deep venous system, can be visualized here. After clamping, the interosseous artery can also be removed. Flap perfusion is always 100%. No suitable confluence can be visualized in the area of the radial vein, several smaller vessels, some of which are less than 1 mm. The flap is then removed, the artery is clamped and sutured with 6.0 Vascufil above and below the inner surface. The veins are ligated. The flap is flushed with heparin. Then lift a piece of full-thickness skin of the appropriate size for the defect from the groin area on the right. After mobilizing the skin, the groin is closed in layers with the insertion of a Redon drain. The skin is successively worked into the defect. Cranial primary wound closure without tension. Dressing with hydrogel/Mepilex. Over this, cloud dressing and wrapping in absorbent cotton. A Cramer splint and loose wrapping in an elastic bandage is applied on top. Hand always well supplied with blood. Saturation at 100%. Good capillary pulse. Application to the hand. Now creation of a two transverse finger wide tunnel from the pharynx on the right into the soft tissues of the neck. Insertion of the flap into the defect. Insertion of the pedicle into the right side of the neck. Successive incorporation of the flap with 3.0 Vicryl single button sutures with low tension. The entire palatal arch area can be covered. In the area of the tonsillar lobe on the left, a portion of the defect in the caudal area of the pharyngeal wall remains uncovered by the flap while the pharyngeal wall is still very well preserved. Tension-free situs. Subsequent vascular anastomosis. Conditioning of the radial artery and the superior thyroid artery. Suture with 8.0 Ethilon single-button sutures. After opening the clamp, good arterial flow, good venous return. Conditioning of two venous outlets from the facial artery. These are each anastomized with 2.5 mm couplers after vessel conditioning. After opening the clamp, good venous return in each case. Smear phenomenon positive in each case. Extensive hemostasis again in both sides of the neck. Wound closure in layers with insertion of a Redon drain on the left and a guided Redon drain on the right. Finally, insertion of a 9 mm tracheostomy tube, which is fixed with sutures. Completion of the procedure without complications. The patient is admitted to the intensive care unit for postoperative monitoring. Please continue intraoperative antibiotics for 2-3 days with Unacid. Heparin perfusor, which was started intraoperatively at 500 I.U./hour, should be continued postoperatively for 5 days. Monitor the flap according to the scheme using clinical checks and Doppler checks. For this purpose, mark the suture on the right side of the neck in the area of the stalk. Feeding via inserted PEG tube. After approx. 10 days, gruel swallowing and, if necessary, food build-up. Overall cT2-3 palatal arch/oropharyngeal carcinoma on both sides. Defect covered by radial flap. Clinically no clear indication of lymph node metastases, but metastases on both sides possible with enlarged lymph nodes. After receiving the histology, please discuss in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/721/InvasionFront_CD3_block21_x3_y7_patient721_0.json b/721/InvasionFront_CD3_block21_x3_y7_patient721_0.json new file mode 100644 index 0000000000000000000000000000000000000000..275c33ccf1b93bd83fc08b439faaa6f901a4d432 --- /dev/null +++ b/721/InvasionFront_CD3_block21_x3_y7_patient721_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 27960.2, + "Num Detections": 25451, + "Num Negative": 23941, + "Num Positive": 1510, + "Positive %": 5.933, + "Num Positive per mm^2": 585.92 + } +} \ No newline at end of file diff --git a/721/InvasionFront_CD3_block21_x4_y7_patient721_1.json b/721/InvasionFront_CD3_block21_x4_y7_patient721_1.json new file mode 100644 index 0000000000000000000000000000000000000000..37d9d64b72d44144bd6df62ef9a51f4686b624dc --- /dev/null +++ b/721/InvasionFront_CD3_block21_x4_y7_patient721_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 28335.0, + "Num Detections": 22477, + "Num Negative": 21573, + "Num Positive": 904, + "Positive %": 4.022, + "Num Positive per mm^2": 381.74 + } +} \ No newline at end of file diff --git a/721/InvasionFront_CD8_block21_x3_y7_patient721_0.json b/721/InvasionFront_CD8_block21_x3_y7_patient721_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8952fc42094ed8e62f37a5fff39f1c2b0403078d --- /dev/null +++ b/721/InvasionFront_CD8_block21_x3_y7_patient721_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10894.2, + "Centroid Y µm": 17115.9, + "Num Detections": 23757, + "Num Negative": 22892, + "Num Positive": 865, + "Positive %": 3.641, + "Num Positive per mm^2": 332.77 + } +} \ No newline at end of file diff --git a/721/InvasionFront_CD8_block21_x4_y7_patient721_1.json b/721/InvasionFront_CD8_block21_x4_y7_patient721_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c29baafa05ca0f06d4ed53136d4a0fb011f19a3b --- /dev/null +++ b/721/InvasionFront_CD8_block21_x4_y7_patient721_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 17190.9, + "Num Detections": 25043, + "Num Negative": 24598, + "Num Positive": 445, + "Positive %": 1.777, + "Num Positive per mm^2": 176.49 + } +} \ No newline at end of file diff --git a/721/TumorCenter_CD3_block21_x3_y7_patient721_0.json b/721/TumorCenter_CD3_block21_x3_y7_patient721_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c969b08b53705cf509a4841384ba86a1ed5722b6 --- /dev/null +++ b/721/TumorCenter_CD3_block21_x3_y7_patient721_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 20064.4, + "Num Detections": 18783, + "Num Negative": 18458, + "Num Positive": 325, + "Positive %": 1.73, + "Num Positive per mm^2": 167.89 + } +} \ No newline at end of file diff --git a/721/TumorCenter_CD3_block21_x4_y7_patient721_1.json b/721/TumorCenter_CD3_block21_x4_y7_patient721_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2ae6c3428053eb16ef23296a772dce5f078faefd --- /dev/null +++ b/721/TumorCenter_CD3_block21_x4_y7_patient721_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 20089.4, + "Num Detections": 17163, + "Num Negative": 16982, + "Num Positive": 181, + "Positive %": 1.055, + "Num Positive per mm^2": 92.31 + } +} \ No newline at end of file diff --git a/721/TumorCenter_CD8_block21_x3_y7_patient721_0.json b/721/TumorCenter_CD8_block21_x3_y7_patient721_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6b1f0d85236801f799dd287bc1b7a63cabe54e97 --- /dev/null +++ b/721/TumorCenter_CD8_block21_x3_y7_patient721_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 32207.9, + "Num Detections": 21993, + "Num Negative": 21810, + "Num Positive": 183, + "Positive %": 0.8321, + "Num Positive per mm^2": 79.43 + } +} \ No newline at end of file diff --git a/721/TumorCenter_CD8_block21_x4_y7_patient721_1.json b/721/TumorCenter_CD8_block21_x4_y7_patient721_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9fc6183a7c2e38f8d138d18f5b6f49cc5c0cba4f --- /dev/null +++ b/721/TumorCenter_CD8_block21_x4_y7_patient721_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 32332.9, + "Num Detections": 20277, + "Num Negative": 20168, + "Num Positive": 109, + "Positive %": 0.5376, + "Num Positive per mm^2": 50.51 + } +} \ No newline at end of file diff --git a/721/history_text.txt b/721/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..de8a2f1ab682be2f9d052c5a4e63993a5dca7878 --- /dev/null +++ b/721/history_text.txt @@ -0,0 +1 @@ +The patient had already been diagnosed with cT4a and cN2b transglottic laryngeal carcinoma in 2010. Had resisted therapy in the further course. Now in 2012, the patient presented again in an emergency when intubation by the emergency physician was impossible due to asphyxia. A new panendoscopy was performed as part of the retracheotomy. This revealed an extensive laryngeal carcinoma, which was confirmed by biopsy to be a poorly differentiated squamous cell carcinoma. The CT scan performed showed a cT4a laryngeal carcinoma on the right side with extensive destruction of the thyroid cartilage and extensive extralaryngeal growth, but no evidence of infiltration of vascular or mediastinal structures. There was also no evidence of distant metastasis, which is why the indication for surgical treatment was given, given the patient's desire for treatment. \ No newline at end of file diff --git a/721/icd_codes.txt b/721/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..566ff193f6ccbe27d6e87e8c2f6ce9635a981eaa --- /dev/null +++ b/721/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, nicht näher bezeichnet[C32.9 ] \ No newline at end of file diff --git a/721/patient_clinical_data.json b/721/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..83b7e6ea0d8113505f839866d3b776f174ae1a96 --- /dev/null +++ b/721/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 671, + "adjuvant_treatment_intent": "palliative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/721/patient_pathological_data.json b/721/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8b2289bbc0148eca27cdeeb0463432eaef69b1cb --- /dev/null +++ b/721/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "721", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 51, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/722/InvasionFront_CD3_block13_x3_y4_patient722_0.json b/722/InvasionFront_CD3_block13_x3_y4_patient722_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1dbf27785ecb8ce530b5dd74c5b5e6f575c2dd07 --- /dev/null +++ b/722/InvasionFront_CD3_block13_x3_y4_patient722_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11031.7, + "Centroid Y µm": 9345.1, + "Num Detections": 8102, + "Num Negative": 7868, + "Num Positive": 234, + "Positive %": 2.888, + "Num Positive per mm^2": 205.47 + } +} \ No newline at end of file diff --git a/722/InvasionFront_CD3_block13_x4_y4_patient722_1.json b/722/InvasionFront_CD3_block13_x4_y4_patient722_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f72541fb0d69cccb37788f7ec08447d0ad56e054 --- /dev/null +++ b/722/InvasionFront_CD3_block13_x4_y4_patient722_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13555.3, + "Centroid Y µm": 9307.6, + "Num Detections": 12913, + "Num Negative": 11156, + "Num Positive": 1757, + "Positive %": 13.61, + "Num Positive per mm^2": 1033.8 + } +} \ No newline at end of file diff --git a/722/InvasionFront_CD8_block13_x3_y4_patient722_0.json b/722/InvasionFront_CD8_block13_x3_y4_patient722_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e77d152943436592c82fe44dd3678d860d1bff06 --- /dev/null +++ b/722/InvasionFront_CD8_block13_x3_y4_patient722_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12343.5, + "Centroid Y µm": 10869.2, + "Num Detections": 16358, + "Num Negative": 15368, + "Num Positive": 990, + "Positive %": 6.052, + "Num Positive per mm^2": 498.0 + } +} \ No newline at end of file diff --git a/722/InvasionFront_CD8_block13_x4_y4_patient722_1.json b/722/InvasionFront_CD8_block13_x4_y4_patient722_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4f1a71571658f396feddf233ab61caf2fe076a70 --- /dev/null +++ b/722/InvasionFront_CD8_block13_x4_y4_patient722_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15017.0, + "Centroid Y µm": 10994.2, + "Num Detections": 16113, + "Num Negative": 14393, + "Num Positive": 1720, + "Positive %": 10.67, + "Num Positive per mm^2": 874.64 + } +} \ No newline at end of file diff --git a/722/TumorCenter_CD3_block13_x3_y4_patient722_0.json b/722/TumorCenter_CD3_block13_x3_y4_patient722_0.json new file mode 100644 index 0000000000000000000000000000000000000000..70e3ea345afd4b01080c2d51d1166a201a59995a --- /dev/null +++ b/722/TumorCenter_CD3_block13_x3_y4_patient722_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12368.5, + "Centroid Y µm": 16316.4, + "Num Detections": 16612, + "Num Negative": 15690, + "Num Positive": 922, + "Positive %": 5.55, + "Num Positive per mm^2": 483.26 + } +} \ No newline at end of file diff --git a/722/TumorCenter_CD3_block13_x4_y4_patient722_1.json b/722/TumorCenter_CD3_block13_x4_y4_patient722_1.json new file mode 100644 index 0000000000000000000000000000000000000000..95218489b9ae62cefbdd2ad031a1aafc2e9a5899 --- /dev/null +++ b/722/TumorCenter_CD3_block13_x4_y4_patient722_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14867.1, + "Centroid Y µm": 16516.3, + "Num Detections": 15530, + "Num Negative": 14144, + "Num Positive": 1386, + "Positive %": 8.925, + "Num Positive per mm^2": 698.29 + } +} \ No newline at end of file diff --git a/722/TumorCenter_CD8_block13_x3_y4_patient722_0.json b/722/TumorCenter_CD8_block13_x3_y4_patient722_0.json new file mode 100644 index 0000000000000000000000000000000000000000..875dad0c8a2f21ae3a023d07576a0ed29b98a76c --- /dev/null +++ b/722/TumorCenter_CD8_block13_x3_y4_patient722_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11244.0, + "Centroid Y µm": 10394.5, + "Num Detections": 14838, + "Num Negative": 14115, + "Num Positive": 723, + "Positive %": 4.873, + "Num Positive per mm^2": 394.83 + } +} \ No newline at end of file diff --git a/722/TumorCenter_CD8_block13_x4_y4_patient722_1.json b/722/TumorCenter_CD8_block13_x4_y4_patient722_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5c23416f8ead18502d90113035d81536634b285a --- /dev/null +++ b/722/TumorCenter_CD8_block13_x4_y4_patient722_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 10019.7, + "Num Detections": 13931, + "Num Negative": 12637, + "Num Positive": 1294, + "Positive %": 9.289, + "Num Positive per mm^2": 679.67 + } +} \ No newline at end of file diff --git a/722/patient_clinical_data.json b/722/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..16bbf3f2f804e30e2f8a36e8793e7806d70b4241 --- /dev/null +++ b/722/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 49, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/722/patient_pathological_data.json b/722/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..74d35779b9f9126ae49ec1f7f48c096dc58fe2c3 --- /dev/null +++ b/722/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "722", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 28, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/723/InvasionFront_CD3_block1_x5_y7_patient723_0.json b/723/InvasionFront_CD3_block1_x5_y7_patient723_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ec5a2c1bc212a16d3bc5d7801cc29d141e4abea --- /dev/null +++ b/723/InvasionFront_CD3_block1_x5_y7_patient723_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 19489.7, + "Num Detections": 28545, + "Num Negative": 26999, + "Num Positive": 1546, + "Positive %": 5.416, + "Num Positive per mm^2": 570.71 + } +} \ No newline at end of file diff --git a/723/InvasionFront_CD8_block1_x6_y7_patient723_1.json b/723/InvasionFront_CD8_block1_x6_y7_patient723_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ee1bdd37ee69c5c2654a4fe817ab28e21c8d069 --- /dev/null +++ b/723/InvasionFront_CD8_block1_x6_y7_patient723_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 18190.4, + "Num Detections": 31141, + "Num Negative": 28400, + "Num Positive": 2741, + "Positive %": 8.802, + "Num Positive per mm^2": 956.77 + } +} \ No newline at end of file diff --git a/728/history_text.txt b/728/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e872de7adcab3ab8d9e23d3b406ea109d231b265 --- /dev/null +++ b/728/history_text.txt @@ -0,0 +1 @@ +The patient has had a foreign body sensation in the uvula for approx. 1 week. No B symptoms at all. If cT1. oral cavity carcinoma is suspected, a panendoscopy with biopsy is indicated. \ No newline at end of file diff --git a/728/ops_codes.txt b/728/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6e7f5ce7aa111dd08207d7b18f378e18d53fc0ca --- /dev/null +++ b/728/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische indirekte Pharyngoskopie Orohypopharyngoskopie[1-611.1 ] Intraoperative diagnostische Tracheoskopie[1-690.1 ] Diagnostische Laryngoskopie direkt[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Probeexzision Uvula[1-546.0 ] \ No newline at end of file diff --git a/728/surgery_description.txt b/728/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..386111ef151f88bf7436ece8b6910cefd464606e --- /dev/null +++ b/728/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy diff --git a/728/surgery_report.txt b/728/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5cfe54b2bdcf23a3981a0af4f46861925d9d0b05 --- /dev/null +++ b/728/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, tracheoscopy is performed with the 0° scope. The trachea is clear up to the carina. Now intubation by the anesthesia colleagues. The surgeon lowers the head and inserts the mouth guard. Inspection of the oral cavity, oropharynx, hypopharynx and larynx with the small bore tube. In the oral cavity, an exophytic tumor of the uvula is visible, which is limited to the soft palate and the nasopharynx itself is also free. The tonsil lobe is free. The pharyngeal wall, the hypopharynx, the epiglottis and the endolarynx are also tumor-free. Now remove the small drainage tube and insert the tonsil plug. The complete overview now shows an exophytic tumor of the uvula, which is limited to the soft palate, does not spread to the hard palate and also leaves the nasopharynx and the posterior wall of the nasopharynx free. Demonstration of findings to , who recommends an excisional biopsy due to the small size of the tumor and to avoid a second operation. This is performed by . The tumor can thus be completely excised with a safety margin of approx. 1 cm. Punctual hemostasis is performed using bipolar coagulation. The completely extirpated uvula tumor is suture-marked on the left side and a secondary resection is performed on the right anterior palatal arch. Following demonstration of the findings and consultation with , a PEG tube is not inserted as the findings suggest that primary swallowing is possible. Esophagogastroscopy is now performed: the esophageal opening is completely clear and non-irritated, as is the esophageal mucosa. A discrete erosive change in the mucosa can be seen in the stomach, otherwise there is no evidence of tumor growth. When the esophagoscope is withdrawn, the esophageal mucosa is assessed again and found to be free and without irritation. Conclusion: The result was a cT1 oral cavity oropharynx carcinoma, which was removed by excisional biopsy. The further procedure should depend on the histology and the patient's ability to swallow, also in conjunction with the CT findings. \ No newline at end of file diff --git a/729/InvasionFront_CD8_block5_x6_y7_patient729_1.json b/729/InvasionFront_CD8_block5_x6_y7_patient729_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f5c4217457c92246547e6e41a8064af0416f3953 --- /dev/null +++ b/729/InvasionFront_CD8_block5_x6_y7_patient729_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 17590.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/729/TumorCenter_CD8_block5_x5_y7_patient729_0.json b/729/TumorCenter_CD8_block5_x5_y7_patient729_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3d34a05b6f9b201be9e58942a216da0da69f54f3 --- /dev/null +++ b/729/TumorCenter_CD8_block5_x5_y7_patient729_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 17465.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/729/history_text.txt b/729/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..48e124122a174e19e2e68070fddc2366c6058a11 --- /dev/null +++ b/729/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the left. Growing through the wall on CT, therefore flap coverage indicated. Size cT2-3. Patient was also informed about possible need for laryngectomy. \ No newline at end of file diff --git a/729/icd_codes.txt b/729/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6498df6028bb3f338253eda1f6ab7f1ff9203c82 --- /dev/null +++ b/729/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/729/ops_codes.txt b/729/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aa2f8747ff36e9df38030f918b5cb23a4b9f8032 --- /dev/null +++ b/729/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Temporäre Tracheotomie[5-311.0 ] Transplantat[5-295.04 ] Entnahme freier Radialis-Lappen[5-858.23 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] \ No newline at end of file diff --git a/729/surgery_description.txt b/729/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..869c8d0e93940e8cd64cf96ee2096eb8535271a7 --- /dev/null +++ b/729/surgery_description.txt @@ -0,0 +1 @@ +Transcervical resection, Bilateral neck dissection, Flap coverage, Free flap (Radial), Tracheotomy diff --git a/729/surgery_report.txt b/729/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7bb5cf506aa09516ea28e28b21d390421709378 --- /dev/null +++ b/729/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and transoral intubation by the anesthesia colleagues. First laryngoscopy and pharyngoscopy: The exophytic tumor can be seen growing into the wall in the area of the pharyngoepiglottic plica transition or starting just below the lower tonsil pole and lying in the area of the lateral piriform sinus on the left. Free arytenoid fold. Transition medially to just on the posterior hypopharyngeal wall. Overall indication for flap coverage probably with preservation of the larynx. Now inject a total of 10 ml Ultracaine 1% with adrenaline into the sides of the neck. Subsequent sterile draping of all areas including radial flap and thigh flap. Start with tracheostoma creation: Kocher's collar incision, slightly widened, which can later be widened into an apron flap. Subsequent dissection through subcutaneous tissue up to the anterior jugular vein, which is cut and ligated on both sides. The infrahyoid muscles are then pushed apart. Exposure of the thyroid isthmus. This is passed underneath, clamped, severed and then ligated using puncture ligatures. Then exposure of the trachea. Enter the 2nd/3rd intercartilaginous space. Incision into the trachea in the sense of a visor tracheotomy. Subsequent epithelialization in the caudal area. Re-intubation and insertion of a laryngectomy tube. Repositioning and sterile washing and draping. Creation of an apron flap in the usual manner. Carry out the neck dissection on the right side. To do this, expose the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Then expose the cervical vascular sheath. It is clear that the jugular vein is infiltrated by a long metastasis. This is deposited in the area of level IV and also deposited at the top. Then the sternocleidomastoid muscle is deposited, which is also infiltrated in the midfield. The accessorius nerve and the cervical plexus must also be removed, so that ultimately only the hypoglossal nerve and the common carotid artery as well as the division of the internal and external arteries remain. The metastasis extends far dorsally into level V b and is completely removed with the neck block. Transition to the other side. The sternocleidomastoid muscle, submandibular gland, omohyoid muscle and digastric muscle are also shown here. Exposure of the cervical vascular sheath and removal of the neck block II to V, sparing the plexus branches, sparing the accessorius nerve and the hypoglossal nerve. Now enter again with the Kleinsasser tube and inspect the tumor. An ulcer-like tumor can be seen, which begins below the tonsil lobe. Determine the entry limit into the pharynx. Then enter the pharynx from the left. Cut around the tumor with a safety margin of 1.5 cm. The specimen is placed on cork for frozen section. In the frozen section, all edges of the specimen are tumor-free and free of carcinoma in situ. Now measure the defect, 12 x 8 cm, and transition to the forearm. Draw a graft of the appropriate size and then palpate the radial artery and ulnar artery. Application of a 300 mmHg tourniquet and cutting of the graft and extension of the incision into the crook of the elbow. Exposure of the venous star in the crook of the elbow. Exposure of the cephalic vein, the basilic vein and the venous confluence. Dissection of the brachioradialis muscle. Dissection of the superficial ramus of the radial nerve. Exposure of the radial artery. Lifting of the graft from the tendon bed, protecting the ulnar artery and the tendons. Dissection of the pedicle up to the crook of the elbow. Then the stem is removed by so that superficial and deep veins remain intact for connection. At the end, close the wound on the arm in the usual way. The tendon of the palmaris longus muscle must be removed in the distal area, as it stretches very far upwards and would probably pass through the split skin. Finally, a dorsal forearm splint was placed. In the meantime, lifted the split skin from the right thigh in the usual way and then transplanted it to the left forearm. Subsequent suturing of the flap into the defect: The flap is sutured successively into the defect with 3-0 single Vicryl button sutures so that a tension-free closure is achieved and the pedicle can be passed to the opposite side for the vascular connections. Dissection of the facial vein and another small outlet directly between the facial and internal jugular veins. For the venous connections and dissection of the facial artery for the arterial anastomosis. Also removal of the submandibular gland for this purpose and for a better overview. Ductus wharton is ligated twice. Subsequent conditioning of the flap vessels and repeated heparin irrigation. The facial artery is sutured to the radial artery using 8-0 Ethilon single-button sutures. Opening of the clamp, good arterial flow, good venous return. The confluent vein is anastomosed to the small outlet between the internal jugular vein and facial vein using a 2-0 coupler. After opening the clamp, good venous return, positive smear phenomenon. The larger of the cephalic branches is then anastomosed to the facial vein using a 3-0 coupler. After opening the clamp, good venous return, positive smear phenomenon. The other outlet had already been clipped when the flap was removed. Subsequent careful hemostasis, irrigation. Closure of the wound with epithelialization of the tracheostoma in layers in a typical manner with insertion of a Redon drain on the left and insertion of 2 flaps on the right. Re-intubation. Insertion of a tracheal tube, which is fixed with sutures. The procedure is then completed without complications. Patient transferred to intensive care unit for monitoring. Please continue antibiotics administered intraoperatively for one week. Upper body elevation. Control of the flap clinically or by Doppler at the marked or suture-fixed site anteriorly on the neck for 5 days according to the control scheme. Feeding via the previously inserted PEG tube for at least 10-12 days, then gruel swallow and, if necessary, diet build-up. Overall cT2-3 hypoharyngeal carcinoma with cN2c status. Postoperative presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/730/InvasionFront_CD3_block14_x1_y7_patient730_0.json b/730/InvasionFront_CD3_block14_x1_y7_patient730_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e778acd2d36d3af6f960da7e600cc7a9fca32e79 --- /dev/null +++ b/730/InvasionFront_CD3_block14_x1_y7_patient730_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4372.7, + "Centroid Y µm": 20963.9, + "Num Detections": 18965, + "Num Negative": 14616, + "Num Positive": 4349, + "Positive %": 22.93, + "Num Positive per mm^2": 1790.6 + } +} \ No newline at end of file diff --git a/730/InvasionFront_CD3_block14_x2_y7_patient730_1.json b/730/InvasionFront_CD3_block14_x2_y7_patient730_1.json new file mode 100644 index 0000000000000000000000000000000000000000..465c6a14bd744a4a7bad37346c4401a726063a1f --- /dev/null +++ b/730/InvasionFront_CD3_block14_x2_y7_patient730_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6996.3, + "Centroid Y µm": 21138.8, + "Num Detections": 18393, + "Num Negative": 15517, + "Num Positive": 2876, + "Positive %": 15.64, + "Num Positive per mm^2": 1247.9 + } +} \ No newline at end of file diff --git a/730/InvasionFront_CD8_block14_x1_y7_patient730_0.json b/730/InvasionFront_CD8_block14_x1_y7_patient730_0.json new file mode 100644 index 0000000000000000000000000000000000000000..303c0f7018e484372180140630a606ea5b7867aa --- /dev/null +++ b/730/InvasionFront_CD8_block14_x1_y7_patient730_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4622.6, + "Centroid Y µm": 16866.1, + "Num Detections": 19150, + "Num Negative": 15967, + "Num Positive": 3183, + "Positive %": 16.62, + "Num Positive per mm^2": 1355.2 + } +} \ No newline at end of file diff --git a/730/InvasionFront_CD8_block14_x2_y7_patient730_1.json b/730/InvasionFront_CD8_block14_x2_y7_patient730_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f61e5dc2a7402787eecff3df3c9b7c6f523f5fc3 --- /dev/null +++ b/730/InvasionFront_CD8_block14_x2_y7_patient730_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7196.2, + "Centroid Y µm": 16991.0, + "Num Detections": 19083, + "Num Negative": 16526, + "Num Positive": 2557, + "Positive %": 13.4, + "Num Positive per mm^2": 1063.1 + } +} \ No newline at end of file diff --git a/730/TumorCenter_CD3_block14_x1_y7_patient730_0.json b/730/TumorCenter_CD3_block14_x1_y7_patient730_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2f135f3d8b2e19510122773ed90fab3e9c5c042e --- /dev/null +++ b/730/TumorCenter_CD3_block14_x1_y7_patient730_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 17365.8, + "Num Detections": 18103, + "Num Negative": 17156, + "Num Positive": 947, + "Positive %": 5.231, + "Num Positive per mm^2": 430.35 + } +} \ No newline at end of file diff --git a/730/TumorCenter_CD3_block14_x2_y7_patient730_1.json b/730/TumorCenter_CD3_block14_x2_y7_patient730_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eca0749b33dcc6149e2cb819698bcd9018d4284b --- /dev/null +++ b/730/TumorCenter_CD3_block14_x2_y7_patient730_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6646.5, + "Centroid Y µm": 17515.7, + "Num Detections": 16840, + "Num Negative": 15392, + "Num Positive": 1448, + "Positive %": 8.599, + "Num Positive per mm^2": 645.83 + } +} \ No newline at end of file diff --git a/730/TumorCenter_CD8_block14_x1_y7_patient730_0.json b/730/TumorCenter_CD8_block14_x1_y7_patient730_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fcd3398a8ca59078fb11dd7915b9b6178e0faded --- /dev/null +++ b/730/TumorCenter_CD8_block14_x1_y7_patient730_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 17990.5, + "Num Detections": 17132, + "Num Negative": 16735, + "Num Positive": 397, + "Positive %": 2.317, + "Num Positive per mm^2": 180.06 + } +} \ No newline at end of file diff --git a/730/TumorCenter_CD8_block14_x2_y7_patient730_1.json b/730/TumorCenter_CD8_block14_x2_y7_patient730_1.json new file mode 100644 index 0000000000000000000000000000000000000000..96cd8532c1359e0495749b3f73e4875b1bc92d55 --- /dev/null +++ b/730/TumorCenter_CD8_block14_x2_y7_patient730_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6021.8, + "Centroid Y µm": 17990.5, + "Num Detections": 17308, + "Num Negative": 16587, + "Num Positive": 721, + "Positive %": 4.166, + "Num Positive per mm^2": 322.28 + } +} \ No newline at end of file diff --git a/730/history_text.txt b/730/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/730/icd_codes.txt b/730/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/730/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/730/ops_codes.txt b/730/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..24061bf101b20f09fd8b8596063f6cb3d563a994 --- /dev/null +++ b/730/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/730/patient_clinical_data.json b/730/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..53b52f003ced49766e13eac69cf570c38966c6de --- /dev/null +++ b/730/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 47, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 4, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/730/patient_pathological_data.json b/730/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8c19b67822ca783e7642b01d1af263ec571738c8 --- /dev/null +++ b/730/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "730", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 10, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/730/surgery_description.txt b/730/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ae0ebbcaaae4e6f166db507421830af7e8e31682 --- /dev/null +++ b/730/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Transoral resection diff --git a/730/surgery_report.txt b/730/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0dbaa0c51a49f9c21e82418875c5fa4cfcf19837 --- /dev/null +++ b/730/surgery_report.txt @@ -0,0 +1 @@ +First, anesthesia induction and transnasal endotracheal intubation by the anesthesia colleagues and positioning of the patient by the surgeon. Subsequent adjustment of the findings at the left edge of the tongue using JENNING's mouth retractor. Inspection. This reveals an ulcerated area on the left edge of the tongue, slightly vulnerable to contact. Clearly indurated in depth and the extent is more likely to be that of a cT2 carcinoma of the left tongue margin. Marking of the incision with a monopolar needle. Successive bypassing of the mass with a satisfactory (inspection and palpation) safety margin. The mass is completely removed and then incised ex vivo. Clear evidence of malignancy. Four marginal samples are taken, which are sent for intraoperative frozen section examination together with the main tumor findings. The intraoperative frozen section examination revealed the diagnosis of a squamous cell carcinoma on the left edge of the tongue, which was completely removed in combination with the four tumor-free edge samples. Hemostasis there by means of bipolar coagulation. The operation was then continued with panendoscopy. Pharyngo- and laryngoscopy using a Kleinsasser C-tube revealed unremarkable findings with no evidence of a secondary malignancy. Flexible endoscopy of the oesophagus and stomach. Inconspicuous findings there, with no evidence of another malignancy in this area. Endoscope inversion and inspection of the esophagogastric junction. Inconspicuous findings there. Withdrawal of the endoscope. Repeated inspection of the oral cavity. Dry conditions there. Completion of the procedure without complications. Conclusion: ct2 cN0 in frozen section R0- resected squamous cell carcinoma of the left edge of the tongue, unremarkable panendoscopy. In the same session, a nasogastric feeding tube was inserted, through which the patient was to be fed for the next five days. Please wait for the final histology and prompt presentation of the patient to the tumor conference with the question of bilateral neck dissection in regions I to III and any necessary adjuvant therapy. Due to the pronounced resection area and the large ............................. loss of the tongue, the functional result must be assessed in the course of the procedure, with the question of flap coverage on the left edge of the tongue. \ No newline at end of file diff --git a/731/InvasionFront_CD3_block13_x1_y9_patient731_0.json b/731/InvasionFront_CD3_block13_x1_y9_patient731_0.json new file mode 100644 index 0000000000000000000000000000000000000000..34960a7bbfcdd72d82a94faf8dda777822b6194b --- /dev/null +++ b/731/InvasionFront_CD3_block13_x1_y9_patient731_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3798.0, + "Centroid Y µm": 21713.5, + "Num Detections": 10758, + "Num Negative": 10728, + "Num Positive": 30, + "Positive %": 0.2789, + "Num Positive per mm^2": 20.59 + } +} \ No newline at end of file diff --git a/731/InvasionFront_CD3_block13_x2_y9_patient731_1.json b/731/InvasionFront_CD3_block13_x2_y9_patient731_1.json new file mode 100644 index 0000000000000000000000000000000000000000..99cd798a5e22a483fc0288fa93e612f0c4d209a5 --- /dev/null +++ b/731/InvasionFront_CD3_block13_x2_y9_patient731_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 21563.6, + "Num Detections": 16117, + "Num Negative": 15849, + "Num Positive": 268, + "Positive %": 1.663, + "Num Positive per mm^2": 128.37 + } +} \ No newline at end of file diff --git a/731/InvasionFront_CD8_block13_x1_y9_patient731_0.json b/731/InvasionFront_CD8_block13_x1_y9_patient731_0.json new file mode 100644 index 0000000000000000000000000000000000000000..066ca9eeb4ccb58c23ac6f7ee7f5a630bd6ed0be --- /dev/null +++ b/731/InvasionFront_CD8_block13_x1_y9_patient731_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4297.7, + "Centroid Y µm": 23187.7, + "Num Detections": 7630, + "Num Negative": 7617, + "Num Positive": 13, + "Positive %": 0.1704, + "Num Positive per mm^2": 14.35 + } +} \ No newline at end of file diff --git a/731/InvasionFront_CD8_block13_x2_y9_patient731_1.json b/731/InvasionFront_CD8_block13_x2_y9_patient731_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c64d09bfa39f5edb7dc8e7aa6f3b433a95bd2853 --- /dev/null +++ b/731/InvasionFront_CD8_block13_x2_y9_patient731_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6771.4, + "Centroid Y µm": 23237.7, + "Num Detections": 8362, + "Num Negative": 7872, + "Num Positive": 490, + "Positive %": 5.86, + "Num Positive per mm^2": 506.73 + } +} \ No newline at end of file diff --git a/731/TumorCenter_CD3_block13_x1_y9_patient731_0.json b/731/TumorCenter_CD3_block13_x1_y9_patient731_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9736380a041eb23a64f299aad9e8f959e2b46d8d --- /dev/null +++ b/731/TumorCenter_CD3_block13_x1_y9_patient731_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 28285.0, + "Num Detections": 13837, + "Num Negative": 13535, + "Num Positive": 302, + "Positive %": 2.183, + "Num Positive per mm^2": 167.48 + } +} \ No newline at end of file diff --git a/731/TumorCenter_CD3_block13_x2_y9_patient731_1.json b/731/TumorCenter_CD3_block13_x2_y9_patient731_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e314d84f3985cdf5f37d7d8863fd65b4e9cf33b --- /dev/null +++ b/731/TumorCenter_CD3_block13_x2_y9_patient731_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 28434.9, + "Num Detections": 14758, + "Num Negative": 14364, + "Num Positive": 394, + "Positive %": 2.67, + "Num Positive per mm^2": 205.93 + } +} \ No newline at end of file diff --git a/731/TumorCenter_CD8_block13_x1_y9_patient731_0.json b/731/TumorCenter_CD8_block13_x1_y9_patient731_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1542ad8549759601c0141667d1299706edaaad63 --- /dev/null +++ b/731/TumorCenter_CD8_block13_x1_y9_patient731_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5472.1, + "Centroid Y µm": 23187.7, + "Num Detections": 17516, + "Num Negative": 17492, + "Num Positive": 24, + "Positive %": 0.137, + "Num Positive per mm^2": 10.79 + } +} \ No newline at end of file diff --git a/731/TumorCenter_CD8_block13_x2_y9_patient731_1.json b/731/TumorCenter_CD8_block13_x2_y9_patient731_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d64ebff149b365ea38cfe91308f7bc3682fa9e01 --- /dev/null +++ b/731/TumorCenter_CD8_block13_x2_y9_patient731_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7945.8, + "Centroid Y µm": 22912.9, + "Num Detections": 20787, + "Num Negative": 20654, + "Num Positive": 133, + "Positive %": 0.6398, + "Num Positive per mm^2": 56.52 + } +} \ No newline at end of file diff --git a/731/history_text.txt b/731/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/731/icd_codes.txt b/731/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dde2596863773ac374f8b9f21d923ea0aab894bc --- /dev/null +++ b/731/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/731/ops_codes.txt b/731/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7fb34bb8e18905f3edc3169bb4eac42011be20f9 --- /dev/null +++ b/731/ops_codes.txt @@ -0,0 +1 @@ +Chordektomie durch Thyreotomie[5-302.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/731/patient_clinical_data.json b/731/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bdc8205ad1066e5043053af0fe84fe25a1e16047 --- /dev/null +++ b/731/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": "palliative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorourcail + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/731/patient_pathological_data.json b/731/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0fc3673720c1b97496e3c97ebc6b1f82dc508303 --- /dev/null +++ b/731/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "731", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/731/surgery_description.txt b/731/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e77381181e0d04412ca4868c9906316ec0e2ba25 --- /dev/null +++ b/731/surgery_description.txt @@ -0,0 +1 @@ +Extended chordectomy and Tracheotomy diff --git a/731/surgery_report.txt b/731/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..62d606148698d17d3f4608f3d0c947baab9fac82 --- /dev/null +++ b/731/surgery_report.txt @@ -0,0 +1 @@ +First of all, induction of anesthesia and intubation by the anesthesia colleagues. Intubation is extremely difficult as the patient is very difficult to adjust. Then intubation with the small bore tube, this is only possible with the D-tube and inspection of the hypopharynx and larynx. No abnormalities in the hypopharynx. Then adjustment of the glottic plane, this is only possible in the posterior two thirds, the anterior commissure cannot be adjusted even after the greatest possible effort. An exophytic mass can be seen in the area of the left vocal fold, which does not infiltrate the arytenoid cartilage, but extends right up to it. Now images with the NBI device and the Cellvizio device by . Rearrangement and injection of Ultracaine. Sterile washing and draping. Zigzag skin incision in the usual manner. Exposure of the prelaryngeal musculature. Push aside the prelaryngeal musculature. Formation of a perichondrium flap. Then sawing open the larynx in the median line. Opening of the larynx and inspection of the tumor region. As previously described, the tumor appears on the left vocal fold, extends to the arytenoid cartilage up to the anterior commissure, but does not infiltrate the opposite side. The tumor extends into the subglottic slope, but does not infiltrate the subglottic region very far down, at most 0.5 cm below the glottic level. Now detach the tumor from the inside of the thyroid cartilage, this can be done without any problems. Temporarily remove the tube and detach the tumor with scissors. The tumor specimen is thread-marked for final histology. A resection is then taken in the area of the pocket fold. Now marginal samples. The marginal samples show invasive carcinoma in the subglottic and arytenoid cartilage and carcinoma in situ in the area of the perichondrium on the inner side of the thyroid cartilage. In this case, the inside of the thyroid cartilage is removed with a diamond burr and resections are made of both the subglottic and the arytenoid cartilage. The tip of the arya falls off. Now close the larynx in the usual way after drilling holes and suturing the ligamentum conicum. Then overlap the perichondrium flap of the thyroid gland and the prelaryngeal musculature. A flap was sutured in beforehand. Then two-layer skin closure and before suturing, a tracheotomy was created between the 2nd and 3rd tracheal cartilage and a mucocutaneous anastomosis was formed. Re-intubation to a tracheal cannula and insertion of a nasogastric tube. Completion of the procedure without complications. Please wait for the histology and plan a follow-up MLE in 6 to 8 weeks. \ No newline at end of file diff --git a/732/InvasionFront_CD3_block1_x5_y12_patient732_0.json b/732/InvasionFront_CD3_block1_x5_y12_patient732_0.json new file mode 100644 index 0000000000000000000000000000000000000000..92666cbc7d64955b1b8e992b8145be5cd54b6cbc --- /dev/null +++ b/732/InvasionFront_CD3_block1_x5_y12_patient732_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15866.6, + "Centroid Y µm": 31908.1, + "Num Detections": 22346, + "Num Negative": 21708, + "Num Positive": 638, + "Positive %": 2.855, + "Num Positive per mm^2": 238.14 + } +} \ No newline at end of file diff --git a/732/InvasionFront_CD3_block1_x6_y12_patient732_1.json b/732/InvasionFront_CD3_block1_x6_y12_patient732_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2ff8e114f29abb510ff080556a900037c8becce7 --- /dev/null +++ b/732/InvasionFront_CD3_block1_x6_y12_patient732_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 32008.1, + "Num Detections": 18021, + "Num Negative": 17509, + "Num Positive": 512, + "Positive %": 2.841, + "Num Positive per mm^2": 200.47 + } +} \ No newline at end of file diff --git a/732/InvasionFront_CD3_block2_x1_y1_patient732_2.json b/732/InvasionFront_CD3_block2_x1_y1_patient732_2.json new file mode 100644 index 0000000000000000000000000000000000000000..d44f7174fc4e6e1b912be2a0eb97ead448df987d --- /dev/null +++ b/732/InvasionFront_CD3_block2_x1_y1_patient732_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6721.4, + "Centroid Y µm": 16166.4, + "Num Detections": 26871, + "Num Negative": 24131, + "Num Positive": 2740, + "Positive %": 10.2, + "Num Positive per mm^2": 1052.1 + } +} \ No newline at end of file diff --git a/732/InvasionFront_CD3_block2_x2_y1_patient732_3.json b/732/InvasionFront_CD3_block2_x2_y1_patient732_3.json new file mode 100644 index 0000000000000000000000000000000000000000..6b805a0a347c98846593f15841d3e220bd4980cd --- /dev/null +++ b/732/InvasionFront_CD3_block2_x2_y1_patient732_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9245.1, + "Centroid Y µm": 15991.5, + "Num Detections": 13449, + "Num Negative": 11779, + "Num Positive": 1670, + "Positive %": 12.42, + "Num Positive per mm^2": 1143.5 + } +} \ No newline at end of file diff --git a/732/InvasionFront_CD8_block1_x5_y12_patient732_0.json b/732/InvasionFront_CD8_block1_x5_y12_patient732_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3b37ac8f86022af98d6b112b5bb705a3ef116e54 --- /dev/null +++ b/732/InvasionFront_CD8_block1_x5_y12_patient732_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 30309.0, + "Num Detections": 23027, + "Num Negative": 22205, + "Num Positive": 822, + "Positive %": 3.57, + "Num Positive per mm^2": 300.72 + } +} \ No newline at end of file diff --git a/732/InvasionFront_CD8_block1_x6_y12_patient732_1.json b/732/InvasionFront_CD8_block1_x6_y12_patient732_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3cabc7649b6db377cc7a15d41f697be9b89b92e --- /dev/null +++ b/732/InvasionFront_CD8_block1_x6_y12_patient732_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 30433.9, + "Num Detections": 21225, + "Num Negative": 20714, + "Num Positive": 511, + "Positive %": 2.408, + "Num Positive per mm^2": 196.53 + } +} \ No newline at end of file diff --git a/732/InvasionFront_CD8_block2_x1_y1_patient732_2.json b/732/InvasionFront_CD8_block2_x1_y1_patient732_2.json new file mode 100644 index 0000000000000000000000000000000000000000..e39cf7a0635d1bc3f4205e3cb084691807afc3f3 --- /dev/null +++ b/732/InvasionFront_CD8_block2_x1_y1_patient732_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5372.2, + "Centroid Y µm": 3823.0, + "Num Detections": 27291, + "Num Negative": 15773, + "Num Positive": 11518, + "Positive %": 42.2, + "Num Positive per mm^2": 4391.3 + } +} \ No newline at end of file diff --git a/732/InvasionFront_CD8_block2_x2_y1_patient732_3.json b/732/InvasionFront_CD8_block2_x2_y1_patient732_3.json new file mode 100644 index 0000000000000000000000000000000000000000..4460197a4095992b04af345bff632b3b601f9ab6 --- /dev/null +++ b/732/InvasionFront_CD8_block2_x2_y1_patient732_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8095.7, + "Centroid Y µm": 3573.1, + "Num Detections": 14533, + "Num Negative": 13556, + "Num Positive": 977, + "Positive %": 6.723, + "Num Positive per mm^2": 705.72 + } +} \ No newline at end of file diff --git a/732/TumorCenter_CD3_block2_x1_y1_patient732_0.json b/732/TumorCenter_CD3_block2_x1_y1_patient732_0.json new file mode 100644 index 0000000000000000000000000000000000000000..86995bc205158cdc719f7ad2e9c32d38e5098387 --- /dev/null +++ b/732/TumorCenter_CD3_block2_x1_y1_patient732_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4797.5, + "Centroid Y µm": 2273.8, + "Num Detections": 15933, + "Num Negative": 12433, + "Num Positive": 3500, + "Positive %": 21.97, + "Num Positive per mm^2": 2195.0 + } +} \ No newline at end of file diff --git a/732/TumorCenter_CD3_block2_x2_y1_patient732_1.json b/732/TumorCenter_CD3_block2_x2_y1_patient732_1.json new file mode 100644 index 0000000000000000000000000000000000000000..57b98beece1133c9c29890b0d6e18ef37afe4d27 --- /dev/null +++ b/732/TumorCenter_CD3_block2_x2_y1_patient732_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7246.2, + "Centroid Y µm": 2373.7, + "Num Detections": 22609, + "Num Negative": 17301, + "Num Positive": 5308, + "Positive %": 23.48, + "Num Positive per mm^2": 2337.0 + } +} \ No newline at end of file diff --git a/732/TumorCenter_CD8_block1_x5_y12_patient732_0.json b/732/TumorCenter_CD8_block1_x5_y12_patient732_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee94909c22f9011baf51b6821374c020acc1a35e --- /dev/null +++ b/732/TumorCenter_CD8_block1_x5_y12_patient732_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19139.9, + "Centroid Y µm": 38704.5, + "Num Detections": 20789, + "Num Negative": 19135, + "Num Positive": 1654, + "Positive %": 7.956, + "Num Positive per mm^2": 664.1 + } +} \ No newline at end of file diff --git a/732/TumorCenter_CD8_block1_x6_y12_patient732_1.json b/732/TumorCenter_CD8_block1_x6_y12_patient732_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ed32056631c4c4f3a99fea7ba8962673d03fb60a --- /dev/null +++ b/732/TumorCenter_CD8_block1_x6_y12_patient732_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21663.5, + "Centroid Y µm": 38504.6, + "Num Detections": 17441, + "Num Negative": 17176, + "Num Positive": 265, + "Positive %": 1.519, + "Num Positive per mm^2": 113.6 + } +} \ No newline at end of file diff --git a/732/TumorCenter_CD8_block2_x1_y1_patient732_2.json b/732/TumorCenter_CD8_block2_x1_y1_patient732_2.json new file mode 100644 index 0000000000000000000000000000000000000000..c2d2cfda209c81c85f1366f4fe7261f836863228 --- /dev/null +++ b/732/TumorCenter_CD8_block2_x1_y1_patient732_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5747.0, + "Centroid Y µm": 2648.6, + "Num Detections": 20223, + "Num Negative": 19594, + "Num Positive": 629, + "Positive %": 3.11, + "Num Positive per mm^2": 407.38 + } +} \ No newline at end of file diff --git a/732/TumorCenter_CD8_block2_x2_y1_patient732_3.json b/732/TumorCenter_CD8_block2_x2_y1_patient732_3.json new file mode 100644 index 0000000000000000000000000000000000000000..232a903f5ad1f476c64d4c35c36387d9db2de3c4 --- /dev/null +++ b/732/TumorCenter_CD8_block2_x2_y1_patient732_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8195.7, + "Centroid Y µm": 2698.6, + "Num Detections": 24264, + "Num Negative": 20844, + "Num Positive": 3420, + "Positive %": 14.09, + "Num Positive per mm^2": 1531.7 + } +} \ No newline at end of file diff --git a/732/history_text.txt b/732/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/732/icd_codes.txt b/732/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..22ac9d327390ac336b814fa425ce8729386048ab --- /dev/null +++ b/732/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/732/ops_codes.txt b/732/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4735934979cd229eaf0ff91358b97bcb06110150 --- /dev/null +++ b/732/ops_codes.txt @@ -0,0 +1 @@ +Weichgaumenteilresektion[5-272.1 ] Weichgaumenteilresektion[5-272.1 ] Pharyngoplastik mit lokaler Schleimhaut[5-293.0 ] Pharyngoplastik mit lokaler Schleimhaut[5-293.0 ] Exstirpation total transoral (erkrankter) harter und weicher Gaumen[5-272.2 ] Exstirpation total transoral (erkrankter) harter und weicher Gaumen[5-272.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] \ No newline at end of file diff --git a/732/patient_clinical_data.json b/732/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f8896ce6310af04f91028e5dd0088335e798f39 --- /dev/null +++ b/732/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 48, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/732/patient_pathological_data.json b/732/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f1f5a9f81623eedecce581a327f3e244412edfe --- /dev/null +++ b/732/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "732", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/732/surgery_report.txt b/732/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d6d868676af8ecda08f549e279995d3ee045112a --- /dev/null +++ b/732/surgery_report.txt @@ -0,0 +1 @@ +The procedure began with a repeat panendoscopy and examination of the oropharynx and hypopharynx. This revealed an exophytic mass at the base of the uvula on the right side and on the soft palate on the right with a questionable transition to the tonsil. The mucosa is uneasily altered here, but shows no exophytic changes in the area of the tonsil. Now insert the mouth retractor and position the patient for TORS resection. Then start with the incision using a monopolar spatula and the Maryland clamp 5 mm around the incision. Start at the base of the uvula, sparing the midline, extending over the soft palate to the tip of the tendon and the posterior arch of the soft palate. The tonsil is then dissected with a margin of soft tissue so that the pharyngeal muscles are not yet reached. The tonsil is then deposited at the lower tonsil pole. Now take an additional marginal sample at the base of the uvula, which is diagnosed here intraoperatively as free in the frozen section. Other specimen, which was sent in marked with a thread for frozen section diagnosis, was then found to be a carcinoma in situ on the soft palate in the middle to lower third, which is why a resection in the sense of a strip resection of the anterior soft palate was performed. Then another marginal sample is taken in the form of a strip of the anterior soft palate, which is then thread-marked and sent for another frozen section examination. This time the tissue is found to be tumor-free. Therefore, careful hemostasis and subsequent repositioning of the patient for neck dissection on both sides. Now continuation of the operation (neck dissection on both sides) by , alternately. Head positioning for neck dissection on the left: Infiltration with 10 ml xylocaine with added adrenaline in the area of the planned skin incision on the left after marking the landmarks in a typical manner. Abjuring and sterile covering of the adjacent areas. Curved skin incision in the area of the anterior border of the sternocleidomastoid muscle. Cut through the skin and platysma, then expose the anterior edge of the sternocleidomastoid muscle. Dissection of the omohyoid muscle and exposure of the internal jugular vein. The external jugular vein was ligated. Then exposure of the accessorius nerve. Now locate the digastric muscle. After identifying all landmarks, insert the retractors caudally. Then dissection of the internal jugular vein and exposure of the cervical vascular sheath with vagus nerve, internal jugular vein and facial vein as well as the common carotid artery. Protect the above-mentioned structures and clear out the entire posterior neck preparation while protecting the accessorius nerve and the entire cervical plexus. Now dissect anteriorly and expose the hypoglossal nerve, the capsule of the submandibular gland and complete the upper neck preparation. Hemostasis using bipolar, no evidence of bleeding. Insertion of a 10-gauge Redon drain and two-layer wound closure. Transfer to right-sided neck dissection: infiltration with 10 ml xylocaine with added adrenaline and another curved skin incision in the area of the anterior edge of the sternocleidomastoid muscle, separation of the platysma, exposure of the anterior edge of the sternocleidomastoid muscle. Then dissection of the level II cervical lymph node metastasis measuring approx. 4 x 5 cm, which can be easily separated from the internal jugular vein and shows no infiltration of the cervical vascular sheath and the sternocleidomastoid muscle. Then expose the omohyoid muscle, then the accessorius nerve and finally the digastric muscle. Insertion of a caudal retractor and preparation on the anterior side of the internal jugular vein for the posterior neck preparation. Then expose the cervical vascular sheath with vagus nerve, internal jugular vein, facial vein and common carotid artery. The above-mentioned structures are spared and traced up to the cervical plexus. Further dissection of the accessorius nerve in a cranial direction and finally clearing out the posterior neck preparation while sparing the accessorius nerve and all plexus branches. Then dissection and visualization of the hypoglossal nerve and the capsule of the submandibular gland with completion of the anterior neck preparation. Final inspection without further mass, no more evidence of bleeding after hemostasis. Insertion of a 10-gauge Redon drain, then two-layer wound closure. Completion of the procedure without complications. Conclusion: R0 resection of a cT2 cN2b oropharyngeal carcinoma on the right (transoral robot-assisted) and neck dissection on both sides Level IIa to V. Procedure: Tumor conference. \ No newline at end of file diff --git a/733/InvasionFront_CD3_block11_x3_y11_patient733_0.json b/733/InvasionFront_CD3_block11_x3_y11_patient733_0.json new file mode 100644 index 0000000000000000000000000000000000000000..83c6b0410e92dc870b9c37d1f16f048483e1e99a --- /dev/null +++ b/733/InvasionFront_CD3_block11_x3_y11_patient733_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 26436.0, + "Num Detections": 17299, + "Num Negative": 16623, + "Num Positive": 676, + "Positive %": 3.908, + "Num Positive per mm^2": 302.83 + } +} \ No newline at end of file diff --git a/733/InvasionFront_CD3_block11_x4_y11_patient733_1.json b/733/InvasionFront_CD3_block11_x4_y11_patient733_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c325747bb4f279745b810c959af50950280dc37a --- /dev/null +++ b/733/InvasionFront_CD3_block11_x4_y11_patient733_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 26311.1, + "Num Detections": 19315, + "Num Negative": 18270, + "Num Positive": 1045, + "Positive %": 5.41, + "Num Positive per mm^2": 459.22 + } +} \ No newline at end of file diff --git a/733/InvasionFront_CD8_block11_x3_y11_patient733_0.json b/733/InvasionFront_CD8_block11_x3_y11_patient733_0.json new file mode 100644 index 0000000000000000000000000000000000000000..11f2d91bae86650416893b6cb6b0d72ae9dc39e3 --- /dev/null +++ b/733/InvasionFront_CD8_block11_x3_y11_patient733_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13688.7, + "Centroid Y µm": 37782.4, + "Num Detections": 17585, + "Num Negative": 17331, + "Num Positive": 254, + "Positive %": 1.444, + "Num Positive per mm^2": 115.16 + } +} \ No newline at end of file diff --git a/733/InvasionFront_CD8_block11_x4_y11_patient733_1.json b/733/InvasionFront_CD8_block11_x4_y11_patient733_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e88dc21ec8a053fb91651ed5e4ad2ccb3e8d7f4 --- /dev/null +++ b/733/InvasionFront_CD8_block11_x4_y11_patient733_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16282.0, + "Centroid Y µm": 37696.3, + "Num Detections": 19637, + "Num Negative": 19223, + "Num Positive": 414, + "Positive %": 2.108, + "Num Positive per mm^2": 183.37 + } +} \ No newline at end of file diff --git a/733/TumorCenter_CD3_block11_x3_y11_patient733_0.json b/733/TumorCenter_CD3_block11_x3_y11_patient733_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a32b732cbfcfaf5cdc678bd86adf1ce2e3f27c0 --- /dev/null +++ b/733/TumorCenter_CD3_block11_x3_y11_patient733_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 27260.6, + "Num Detections": 13726, + "Num Negative": 13486, + "Num Positive": 240, + "Positive %": 1.749, + "Num Positive per mm^2": 112.24 + } +} \ No newline at end of file diff --git a/733/TumorCenter_CD3_block11_x4_y11_patient733_1.json b/733/TumorCenter_CD3_block11_x4_y11_patient733_1.json new file mode 100644 index 0000000000000000000000000000000000000000..19ff84dd605da1bd8e1e9289b0d4f15fcd5fc26b --- /dev/null +++ b/733/TumorCenter_CD3_block11_x4_y11_patient733_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 27435.5, + "Num Detections": 16393, + "Num Negative": 15669, + "Num Positive": 724, + "Positive %": 4.417, + "Num Positive per mm^2": 321.34 + } +} \ No newline at end of file diff --git a/733/TumorCenter_CD8_block11_x3_y11_patient733_0.json b/733/TumorCenter_CD8_block11_x3_y11_patient733_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a0dcf4b0570b32977595571647ce1044e601903c --- /dev/null +++ b/733/TumorCenter_CD8_block11_x3_y11_patient733_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 27110.6, + "Num Detections": 12170, + "Num Negative": 12083, + "Num Positive": 87, + "Positive %": 0.7149, + "Num Positive per mm^2": 40.02 + } +} \ No newline at end of file diff --git a/733/TumorCenter_CD8_block11_x4_y11_patient733_1.json b/733/TumorCenter_CD8_block11_x4_y11_patient733_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ef62af8c70c6ad528157feece4d52b4da314763c --- /dev/null +++ b/733/TumorCenter_CD8_block11_x4_y11_patient733_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 27235.6, + "Num Detections": 17136, + "Num Negative": 16767, + "Num Positive": 369, + "Positive %": 2.153, + "Num Positive per mm^2": 154.93 + } +} \ No newline at end of file diff --git a/734/InvasionFront_CD3_block4_x5_y7_patient734_0.json b/734/InvasionFront_CD3_block4_x5_y7_patient734_0.json new file mode 100644 index 0000000000000000000000000000000000000000..af34d135ae713e9edd81e97a351c0f45935be88f --- /dev/null +++ b/734/InvasionFront_CD3_block4_x5_y7_patient734_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 23662.5, + "Num Detections": 24725, + "Num Negative": 19220, + "Num Positive": 5505, + "Positive %": 22.26, + "Num Positive per mm^2": 2071.6 + } +} \ No newline at end of file diff --git a/734/InvasionFront_CD3_block4_x6_y7_patient734_1.json b/734/InvasionFront_CD3_block4_x6_y7_patient734_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4bb878cb26540466fc9fa1051f7ad22bb7d730e9 --- /dev/null +++ b/734/InvasionFront_CD3_block4_x6_y7_patient734_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21513.6, + "Centroid Y µm": 23762.4, + "Num Detections": 24930, + "Num Negative": 18716, + "Num Positive": 6214, + "Positive %": 24.93, + "Num Positive per mm^2": 2298.5 + } +} \ No newline at end of file diff --git a/734/TumorCenter_CD3_block4_x5_y7_patient734_0.json b/734/TumorCenter_CD3_block4_x5_y7_patient734_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bd24120aa90c8a62e0793f05d976ef16155dbdd2 --- /dev/null +++ b/734/TumorCenter_CD3_block4_x5_y7_patient734_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 17865.5, + "Num Detections": 22845, + "Num Negative": 15746, + "Num Positive": 7099, + "Positive %": 31.07, + "Num Positive per mm^2": 2753.2 + } +} \ No newline at end of file diff --git a/734/TumorCenter_CD3_block4_x6_y7_patient734_1.json b/734/TumorCenter_CD3_block4_x6_y7_patient734_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cdfe64c48473c114e07a0b9b2ba89d3032fd6038 --- /dev/null +++ b/734/TumorCenter_CD3_block4_x6_y7_patient734_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 17915.5, + "Num Detections": 22117, + "Num Negative": 12507, + "Num Positive": 9610, + "Positive %": 43.45, + "Num Positive per mm^2": 3740.8 + } +} \ No newline at end of file