diff --git a/308/surgery_description.txt b/308/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b36a4bfdb8a810443e3fdd3c6e530969f93a8ab0 --- /dev/null +++ b/308/surgery_description.txt @@ -0,0 +1 @@ +Frontolateral laryngeal partial resection/Chordectomy diff --git a/308/surgery_report.txt b/308/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d36032c7e835703163a2690e633274bc1356c9a6 --- /dev/null +++ b/308/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first perform the microlaryngoscopy. Adjustment of the endolarynx with the Kleinsasser B and JA tube. Demonstration of the findings on . This shows tumor growth in the area of the right vocal fold, which occupies the entire right vocal fold and extends to the vocal process. Towards the anterior commissure, this appears to be reached. Laterally, the tumor is palpable in the area of the ventricle. Subsequently, a decision was made to perform an open partial laryngectomy. Subsequent sterile washing and draping. Serrated vertical skin incision with exposure of the prelaryngeal musculature, which is pushed apart along the linea alba. Then expose the laryngeal skeleton by pushing the cricothyroid muscle from the lower edge of the cricoid cartilage to the thyrohyoid membrane. Incision of the periosteum or perichondrium so that a right pedicled perichondrium flap of the thyroid cartilage is formed. Enter the subperichondrial layer in the area of the thyroid incisura and dissect caudally. Then pass through the thyrofissure in the median plane so that the thyroid cartilage can be pushed apart. There is no clinical evidence of infiltration in the area of the anterior commissure. Entry into the interior of the larynx in the area of the thyroid incisura. From here, the incision is first made caudally in a vertical direction and the anterior commissure is included in the resection. In this way, the tumour can be successively visualized. The resection proceeds to the right, including the perichondrium in the area of the medial half of the right half of the thyroid cartilage. The tumor is then removed caudally in the area of the subglottis as well as cranially, whereby the resection includes parts of the ventriculus laryngeus. Finally, the tumor and thus the entire vocal fold is removed dorsally using the Kittel scissors with resection of the vocal process on the arytenoid cartilage. Macroscopically, the resection margins are not suspicious. The entire specimen is then thread-marked and mounted on cork for a frozen section histological examination. The dorsal part of the subglottic resection margin still shows carcinoma extensions. A subglottic dorsal resection is therefore performed. Lateral to this resection, further marginal samples are taken as well as a further marginal sample in the area of the remaining arytenoid cartilage. These proved to be free of tumor and dysplasia in the frozen section histological examination, so that an R0 resection can be assumed here. Finally, careful hemostasis by bipolar coagulation. Sealing of the wound surface on the right side with fibrin glue. Drill holes are made for readaptation of the thyroid cartilage. Insertion of a Keel after appropriate individual modeling. Readaptation of the thyroid cartilage skeleton at the previously created cranial and caudal drill holes. Refixation of the ligamentum conicum to the caudal edge of the thyroid cartilage. Knock-back of the perichondrium flap, which is additionally fixed with fibrin glue. Multi-layer wound closure of the straight prelaryngeal musculature after insertion of a drainage flap. Finally, multi-layer skin suture. Sterile wound dressing. End of the operation and transfer of the patient to anesthesia after placement of a nasogastric feeding tube and microlaryngoscopic control of the dry wound bed endolaryngeally. Conclusion: Complete right chordectomy for right vocal fold carcinoma via thyrofissure. Inclusion of the anterior commissure as well as the vocal process of the arytenoid cartilage. Control microlaryngoscopy in 8 weeks. \ No newline at end of file diff --git a/309/InvasionFront_CD8_block21_x1_y11_patient309_0.json b/309/InvasionFront_CD8_block21_x1_y11_patient309_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b28f0eb87042142e2d1ea69612259d99d628120 --- /dev/null +++ b/309/InvasionFront_CD8_block21_x1_y11_patient309_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3423.2, + "Centroid Y µm": 27035.7, + "Num Detections": 16318, + "Num Negative": 16298, + "Num Positive": 20, + "Positive %": 0.1226, + "Num Positive per mm^2": 9.649 + } +} \ No newline at end of file diff --git a/309/InvasionFront_CD8_block21_x2_y11_patient309_1.json b/309/InvasionFront_CD8_block21_x2_y11_patient309_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f3cc98cd1f5f222eca497b4a1d2212b27a4914c1 --- /dev/null +++ b/309/InvasionFront_CD8_block21_x2_y11_patient309_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6021.8, + "Centroid Y µm": 27035.7, + "Num Detections": 17234, + "Num Negative": 17037, + "Num Positive": 197, + "Positive %": 1.143, + "Num Positive per mm^2": 90.27 + } +} \ No newline at end of file diff --git a/309/TumorCenter_CD3_block21_x1_y11_patient309_0.json b/309/TumorCenter_CD3_block21_x1_y11_patient309_0.json new file mode 100644 index 0000000000000000000000000000000000000000..509cc868707b9bb7d84333ea0e4dc94a859d158c --- /dev/null +++ b/309/TumorCenter_CD3_block21_x1_y11_patient309_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3873.0, + "Centroid Y µm": 30170.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/309/TumorCenter_CD3_block21_x2_y11_patient309_1.json b/309/TumorCenter_CD3_block21_x2_y11_patient309_1.json new file mode 100644 index 0000000000000000000000000000000000000000..32fdad5ab45f2454caf5ebc73e7f81678df9f685 --- /dev/null +++ b/309/TumorCenter_CD3_block21_x2_y11_patient309_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6361.9, + "Centroid Y µm": 29834.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/309/TumorCenter_CD8_block21_x1_y11_patient309_0.json b/309/TumorCenter_CD8_block21_x1_y11_patient309_0.json new file mode 100644 index 0000000000000000000000000000000000000000..10fcd2c04aa9a983e3214e5023362104cd03dac9 --- /dev/null +++ b/309/TumorCenter_CD8_block21_x1_y11_patient309_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5647.0, + "Centroid Y µm": 42059.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/309/TumorCenter_CD8_block21_x2_y11_patient309_1.json b/309/TumorCenter_CD8_block21_x2_y11_patient309_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f8f66c814cfe712753e65503ed4766e3aa99c46 --- /dev/null +++ b/309/TumorCenter_CD8_block21_x2_y11_patient309_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8245.6, + "Centroid Y µm": 41984.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/309/history_text.txt b/309/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/309/icd_codes.txt b/309/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/309/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/309/ops_codes.txt b/309/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5700f143129d267b7baa80e51692e18f3f555f47 --- /dev/null +++ b/309/ops_codes.txt @@ -0,0 +1 @@ +Andere partielle Laryngektomie: Endoskopische Laserresektion[5-302.5 ] \ No newline at end of file diff --git a/309/patient_clinical_data.json b/309/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2ad8d1abca72df0b53caeb4fac2d382c9c9f79da --- /dev/null +++ b/309/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/309/patient_pathological_data.json b/309/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4481c2cc18bebb0c4bb23b1ba6d78acc5e1a2455 --- /dev/null +++ b/309/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "309", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/309/surgery_description.txt b/309/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..19aef526c8a939825eaa75968cc34d4c2327f9d9 --- /dev/null +++ b/309/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngectomy diff --git a/309/surgery_report.txt b/309/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..dae2a2e9993e5f99de4bd2b4ebb993216e07620c --- /dev/null +++ b/309/surgery_report.txt @@ -0,0 +1 @@ +First, advance the O° optic through the glottic plane into the trachea. Inconspicuous mucosal conditions in the area of the trachea. Further advancement of the endoscope into the bronchial system, inconspicuous conditions on both sides. Now intubation of the patient. Then inspection of the hypopharynx on both sides, the postcricoid region, the oropharynx, the oral cavity and the nasopharynx. All mucosal conditions were unremarkable. All inspections with the aid of the endoscope or microscope. Now inspection of the larynx. A tumor was found in the area of the left vocal fold, extending from the tip of the arytenoid cartilage to just before the anterior commissure, occupying the entire vocal cord and extending to just before the morgue sinus. The tumor is located strictly on the left side. Beyond that, there are no special features in the subglottis and supraglottis. First, a sample is obtained and sent for frozen section histology. Here the diagnosis of squamous cell carcinoma is made. As a result, the process is resected with a laser from the tip of the arytenoid cartilage to the anterior commissure, including the largest parts of the vocalis muscle. The tumor is removed in the area of the anterior commissure together with the perichondrium, the thyroid cartilage. Deposition of the tumor, careful hemostasis. Obtain two representative marginal samples. Termination of the procedure if conditions are dry overall. A control endoscopy in 6-8 weeks is absolutely indicated. \ No newline at end of file diff --git a/310/InvasionFront_CD3_block7_x5_y1_patient310_0.json b/310/InvasionFront_CD3_block7_x5_y1_patient310_0.json new file mode 100644 index 0000000000000000000000000000000000000000..355628f26625ff6848a0ba449a39892a4fa5ea1e --- /dev/null +++ b/310/InvasionFront_CD3_block7_x5_y1_patient310_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16816.1, + "Centroid Y µm": 2273.8, + "Num Detections": 18293, + "Num Negative": 17301, + "Num Positive": 992, + "Positive %": 5.423, + "Num Positive per mm^2": 428.79 + } +} \ No newline at end of file diff --git a/310/InvasionFront_CD3_block7_x6_y1_patient310_1.json b/310/InvasionFront_CD3_block7_x6_y1_patient310_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd4a77dc0725940d50556dffc185df02f77b7ae0 --- /dev/null +++ b/310/InvasionFront_CD3_block7_x6_y1_patient310_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19323.1, + "Centroid Y µm": 2178.1, + "Num Detections": 15039, + "Num Negative": 12633, + "Num Positive": 2406, + "Positive %": 16.0, + "Num Positive per mm^2": 1313.6 + } +} \ No newline at end of file diff --git a/310/InvasionFront_CD8_block7_x5_y1_patient310_0.json b/310/InvasionFront_CD8_block7_x5_y1_patient310_0.json new file mode 100644 index 0000000000000000000000000000000000000000..55c5735544643ca7ae27221697aee9da27f14745 --- /dev/null +++ b/310/InvasionFront_CD8_block7_x5_y1_patient310_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 3573.1, + "Num Detections": 16366, + "Num Negative": 15849, + "Num Positive": 517, + "Positive %": 3.159, + "Num Positive per mm^2": 242.89 + } +} \ No newline at end of file diff --git a/310/InvasionFront_CD8_block7_x6_y1_patient310_1.json b/310/InvasionFront_CD8_block7_x6_y1_patient310_1.json new file mode 100644 index 0000000000000000000000000000000000000000..515528d8932b5a0771be659c461c1e0d323a94e5 --- /dev/null +++ b/310/InvasionFront_CD8_block7_x6_y1_patient310_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21338.7, + "Centroid Y µm": 3823.0, + "Num Detections": 13265, + "Num Negative": 12037, + "Num Positive": 1228, + "Positive %": 9.257, + "Num Positive per mm^2": 762.61 + } +} \ No newline at end of file diff --git a/310/TumorCenter_CD3_block7_x5_y1_patient310_0.json b/310/TumorCenter_CD3_block7_x5_y1_patient310_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aa5cb5c03644b3872d5ac782c76002bec6b9baf7 --- /dev/null +++ b/310/TumorCenter_CD3_block7_x5_y1_patient310_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 2873.5, + "Num Detections": 10893, + "Num Negative": 10160, + "Num Positive": 733, + "Positive %": 6.729, + "Num Positive per mm^2": 564.3 + } +} \ No newline at end of file diff --git a/310/TumorCenter_CD3_block7_x6_y1_patient310_1.json b/310/TumorCenter_CD3_block7_x6_y1_patient310_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d67114b3b69f5d5505b0a2f6a242901e68575859 --- /dev/null +++ b/310/TumorCenter_CD3_block7_x6_y1_patient310_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 2923.5, + "Num Detections": 18300, + "Num Negative": 17630, + "Num Positive": 670, + "Positive %": 3.661, + "Num Positive per mm^2": 298.29 + } +} \ No newline at end of file diff --git a/310/TumorCenter_CD8_block7_x5_y1_patient310_0.json b/310/TumorCenter_CD8_block7_x5_y1_patient310_0.json new file mode 100644 index 0000000000000000000000000000000000000000..455bfb0b6f6d7fe6bb9fa451a8c042b31f9c689f --- /dev/null +++ b/310/TumorCenter_CD8_block7_x5_y1_patient310_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 3273.3, + "Num Detections": 16096, + "Num Negative": 15744, + "Num Positive": 352, + "Positive %": 2.187, + "Num Positive per mm^2": 220.26 + } +} \ No newline at end of file diff --git a/310/TumorCenter_CD8_block7_x6_y1_patient310_1.json b/310/TumorCenter_CD8_block7_x6_y1_patient310_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1d7170804eb64700ddd562f5a650ed1ec473cd05 --- /dev/null +++ b/310/TumorCenter_CD8_block7_x6_y1_patient310_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 3498.1, + "Num Detections": 20580, + "Num Negative": 20447, + "Num Positive": 133, + "Positive %": 0.6463, + "Num Positive per mm^2": 57.51 + } +} \ No newline at end of file diff --git a/310/history_text.txt b/310/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/310/icd_codes.txt b/310/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/310/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/310/ops_codes.txt b/310/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..247dc821a9e271f7afa3a350addc1f0b0794d417 --- /dev/null +++ b/310/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Temporäre Tracheotomie[5-311.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Großflächige freie Spalthauttransplantation auf granulierendes Hautareal am Unterarm[5-902.58 L] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] \ No newline at end of file diff --git a/310/patient_clinical_data.json b/310/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b2a7e5637fcb0b08c613a4fe56390de740f08c9b --- /dev/null +++ b/310/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 47, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 32, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/310/patient_pathological_data.json b/310/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..06ee4c2d7140f06c4120ef7f491406bb6898992a --- /dev/null +++ b/310/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "310", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/310/surgery_description.txt b/310/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..660c0571298bf82bc9bfba6cd729f76130256367 --- /dev/null +++ b/310/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheostomy, PEG placement diff --git a/310/surgery_report.txt b/310/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b05591260acade3d686eb59998d1f9a681059c8b --- /dev/null +++ b/310/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation by the anesthesia department, the PEG is first inserted by . The PEG is inserted and secured using the usual technique. Then transition to tracheostoma placement. After skin disinfection, infiltration with local anesthetic containing adrenaline in the area of the subsequent skin incision as well as the tracheostoma. Sterile washing and draping. Skin incision approx. 2 QF above the jugulum. Sharp dissection through the subcutaneous fatty tissue down to the prelaryngeal musculature. This is divided along the linea alba. Exposure of the very strong isthmus of the thyroid gland. The isthmus is then passed under the pretracheal lamina, clamped and repositioned. This clearly exposes the upper trachea and the cricoid cartilage. The visor tracheotomy is then performed between the 2nd and 3rd tracheal cartilage. Creation of the mucocutaneous anastomosis with 2 sutures each cranially and caudally. Problem-free reintubation of the patient. Then transition to tumor resection. Here, the tumor is positioned with the tonsil retractor. The ulcerative tumor in the area of the right oropharynx, dorsal to the posterior mandibular molar, is not very well defined. First start with caudal tumor resection. The adjacent base of the tongue is biopsied first, which is found to be tumor-free on frozen section histology, as is the adjacent maxilla. Now first cut around the resection margins caudally in the area of the medial base of the tongue in a lateral direction towards the mandible. The mucosa of the lateral floor of the mouth is incised up to the penultimate premolar. The resection is then guided laterally over the gingiva between the last and penultimate molars and continues in an arc over the adjacent buccal mucosa cranially to the maxilla. From there, the right soft palate is parauvularly incised almost to the midline. The resection then proceeds, including the posterior palatal arch, to the back wall of the pharynx, where it is then rejoined at the lower pole of the tonsil or base of the tongue. During resection, the last morale on the right side is then removed. The tumor is then successively resected along these borders together with the surrounding soft tissue. The posterior part of the lingual nerve is exposed and must also be resected in order to maintain an appropriate safety distance. Finally, the tumor can be completely removed by pushing the periosteum away from the mandible and thus completely exposing the mandibular angle from the medial side down to the bare bone. Multiple frozen section histological samples are taken from the surrounding resection margin as well as from the base of the tumor, all of which prove to be tumor-free. The last molar on the right side is then extracted and the adjacent mandible is ground out with the drill and smoothed. Also the root canals. After tumor resection, measurement of a 9 x 6.5 cm long radial flap graft, which will be lifted from the left forearm by . Distal skin incision and dissection through the subcutaneous fatty tissue. Expose the cephalic vein and dissect radially from it. Exposure of the muscle bellies of the flexor carpi radialis and brachioradialis muscles and exposure of the venous star as well as exposure of the pedicle in depth. Now free dissection of the muscle bellies distally and exposure of the complete pedicle. Dissection of the cephalic vein and the radial vein as potential connecting vessels. Exposure of the brachial and ulnar arteries and exposure of the proximal end of the radial artery. Clipping of small perforator vessels and ligation of larger veins and arteries. Now ulnar recutting of the flap while sparing the ulnar artery and dissection up to the flexor carpi radialis tendon. Now also radially recut the flap and follow the cephalic artery distally. This is included in the subcutaneous fatty tissue of the graft. The R. superficialis of the radial nerve can be preserved with its two branches. Separation of the cephalic vein distally. Complete removal of the transplant. Finally, removal of the radial artery distally and proximally and removal of the two venous outlets. Ligation of the vascular stumps. Arm closure after careful hemostasis using a split-thigh skin graft of the right thigh, which was obtained in the usual manner. Application of a plaster splint. Good recapillarization time after removal of the flap. Subsequent transition to neck dissection on the right side. After skin incision, dissection and skeletonization of the sternocleidomastoid muscle. Then expose the cervical vascular nerve sheath caudally and dissect cranially, sparing all non-lymphatic structures. Regions II to V are thus completely cleared out first. Submandibulectomy and removal of region I are then performed. In the area of the submandibular lobe, the pharyngeal passage into the defect is also found. Insertion of a Redon suction drainage. Subsequently, transition to neck dissection on the left side. Here, regions II to V are completely evacuated while preserving all non-lymphatic structures. After placement of the radial lobe graft, it is then inserted into the oropharyngeal defect from the lateral side via the previously created access and initially fixed to its cranial attachment site with several sutures. Then suture via the transcervical access of the caudal flap edge. Finally, the flap is fixed in position with the remaining sutures from the transoral side. The microvascular anastomosis is then performed. The arterial anastomosis is performed with the ascending pharyngeal artery, as both the superior thyroid artery and the facial artery are extremely small in caliber. The venous anastomoses are performed in the usual manner via 2 veins to the internal jugular vein using the end-to-side technique. Finally, insertion of a drainage flap in the right side of the neck. Two-layer wound closure. End of the operation, transfer of the patient to the anesthesia department after the patient has been reintubated onto an 8-gauge tracheostomy tube, which is sutured to the skin. Prior to this, wound closure on the left side after insertion of a Redon suction drain. End of the operation, transfer of the patient to anesthesia. Conclusion: Transoral tumor resection of a cT3 oropharyngeal carcinoma on the right side in the region of the mandibular angle with extraction of the last molar from the right mandible and corresponding grinding of the adjacent bone. Microvascular reconstruction with a radial flap graft from the left forearm and defect coverage on the left forearm with split skin from the right thigh, creation of a tracheostoma and a PEG. \ No newline at end of file diff --git a/311/InvasionFront_CD3_block12_x3_y8_patient311_0.json b/311/InvasionFront_CD3_block12_x3_y8_patient311_0.json new file mode 100644 index 0000000000000000000000000000000000000000..59e342b1de0a475cb56669564a8e240d6feab370 --- /dev/null +++ b/311/InvasionFront_CD3_block12_x3_y8_patient311_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 24661.9, + "Num Detections": 18550, + "Num Negative": 18132, + "Num Positive": 418, + "Positive %": 2.253, + "Num Positive per mm^2": 192.07 + } +} \ No newline at end of file diff --git a/311/InvasionFront_CD3_block12_x4_y8_patient311_1.json b/311/InvasionFront_CD3_block12_x4_y8_patient311_1.json new file mode 100644 index 0000000000000000000000000000000000000000..821833f9a89f4239b8f426d936df56c88a2a065b --- /dev/null +++ b/311/InvasionFront_CD3_block12_x4_y8_patient311_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 24864.7, + "Num Detections": 20513, + "Num Negative": 18672, + "Num Positive": 1841, + "Positive %": 8.975, + "Num Positive per mm^2": 780.19 + } +} \ No newline at end of file diff --git a/311/InvasionFront_CD8_block12_x3_y8_patient311_0.json b/311/InvasionFront_CD8_block12_x3_y8_patient311_0.json new file mode 100644 index 0000000000000000000000000000000000000000..91fad49460db6391d7cf07320ca8df6d5ab2180c --- /dev/null +++ b/311/InvasionFront_CD8_block12_x3_y8_patient311_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12343.5, + "Centroid Y µm": 23912.3, + "Num Detections": 18571, + "Num Negative": 16277, + "Num Positive": 2294, + "Positive %": 12.35, + "Num Positive per mm^2": 1006.1 + } +} \ No newline at end of file diff --git a/311/InvasionFront_CD8_block12_x4_y8_patient311_1.json b/311/InvasionFront_CD8_block12_x4_y8_patient311_1.json new file mode 100644 index 0000000000000000000000000000000000000000..836f995c49f3fb93e0a4247f455877f3fe4992fd --- /dev/null +++ b/311/InvasionFront_CD8_block12_x4_y8_patient311_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14992.1, + "Centroid Y µm": 23787.4, + "Num Detections": 20871, + "Num Negative": 18362, + "Num Positive": 2509, + "Positive %": 12.02, + "Num Positive per mm^2": 1044.5 + } +} \ No newline at end of file diff --git a/311/TumorCenter_CD3_block12_x3_y8_patient311_0.json b/311/TumorCenter_CD3_block12_x3_y8_patient311_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a9be14d095f85d8cdba62b5f910ef254344278db --- /dev/null +++ b/311/TumorCenter_CD3_block12_x3_y8_patient311_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10619.4, + "Centroid Y µm": 19939.4, + "Num Detections": 21392, + "Num Negative": 17107, + "Num Positive": 4285, + "Positive %": 20.03, + "Num Positive per mm^2": 1861.9 + } +} \ No newline at end of file diff --git a/311/TumorCenter_CD3_block12_x4_y8_patient311_1.json b/311/TumorCenter_CD3_block12_x4_y8_patient311_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9dd3cdbc17bfc889052a2153340f8ab4214c46b --- /dev/null +++ b/311/TumorCenter_CD3_block12_x4_y8_patient311_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13168.0, + "Centroid Y µm": 20014.4, + "Num Detections": 20299, + "Num Negative": 17343, + "Num Positive": 2956, + "Positive %": 14.56, + "Num Positive per mm^2": 1244.7 + } +} \ No newline at end of file diff --git a/311/TumorCenter_CD8_block12_x3_y8_patient311_0.json b/311/TumorCenter_CD8_block12_x3_y8_patient311_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a7974c9d3da59db9fc493989f58594981bee4d59 --- /dev/null +++ b/311/TumorCenter_CD8_block12_x3_y8_patient311_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 29234.5, + "Num Detections": 19849, + "Num Negative": 17013, + "Num Positive": 2836, + "Positive %": 14.29, + "Num Positive per mm^2": 1246.1 + } +} \ No newline at end of file diff --git a/311/TumorCenter_CD8_block12_x4_y8_patient311_1.json b/311/TumorCenter_CD8_block12_x4_y8_patient311_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7054036f897948cd67577eccc2f6c267b3335119 --- /dev/null +++ b/311/TumorCenter_CD8_block12_x4_y8_patient311_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16166.4, + "Centroid Y µm": 29434.4, + "Num Detections": 17062, + "Num Negative": 15012, + "Num Positive": 2050, + "Positive %": 12.02, + "Num Positive per mm^2": 925.93 + } +} \ No newline at end of file diff --git a/311/history_text.txt b/311/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/311/icd_codes.txt b/311/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/311/ops_codes.txt b/311/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/311/patient_clinical_data.json b/311/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..79ca799e8057333357d0ba26bf04a02d7eab407d --- /dev/null +++ b/311/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 52, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 45, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/311/patient_pathological_data.json b/311/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4fb92312858af08769653a6a26445372998bf404 --- /dev/null +++ b/311/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "311", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/311/surgery_description.txt b/311/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a6522716351b0260c805a0a79d1019b2c1934f0b --- /dev/null +++ b/311/surgery_description.txt @@ -0,0 +1 @@ +Resection of Tonsillar carcinoma, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheotomy diff --git a/311/surgery_report.txt b/311/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6e98cdb28b08f8fe332458002ec56ff54a9aff7d --- /dev/null +++ b/311/surgery_report.txt @@ -0,0 +1 @@ +At the beginning of the operation, the surgeon positions the patient. After induction of anesthesia, the tumor is inspected again. This extends from the soft palate close to the uvula down to the lower tonsillar pole with transition via the glossotonsillar groove to the base of the tongue. Laterally, the tumor appears to extend to the posterior molars. After insertion of the tonsil retractor and insertion of the monopolar electric needle, the tumor is cut around far into the healthy tissue and removed, taking the uvula, the soft palate on the left up to the hard palate border and the upper alveolar ridge, from here to the lower alveolar ridge. Removal of the last molar and preparation via the glossotonsillar groove to the base of the tongue. Removal of the tonsil in its capsule. Mucosa up to the buccal mucosa and the floor of the mouth as a post-resection. Then take lateral and medial edge samples. These are now found to be tumor-free. To confirm the R0 situation, the bed of the two extracted molars is now removed from the medial side to the lateral corticalis with the rose bur, taking the corticalis with it, so that a safe R0 resection appears to be given. Intraoperative demonstration on and . Removal of the tonsil plug. The bridge of the maxilla breaks out at the front. It becomes apparent that the tooth roots could not be preserved, so these are also removed. A residual root may have remained on the left paramedian side. Therefore, request a postoperative maxillofacial consultation. In the further course, repositioning for neck dissection, starting on the left side: skin incision along the anterior edge of the sternocleidomastoid. Exposure of the cervical vascular sheath. Laborious exploration of the neck vessels and preservation of the same for later defect coverage. Dissection in the accessorius triangle and exploration of the accessorius, the hypoglossus and the cervical sinus. Dissection from the digaster to the caudal omohyoid. Removal of the lateral neck preparation while sparing the above-mentioned structures and the main plexus branches. Then dissect the capsule of the submandibular gland in the midline. Dissect caudally, preserving the above-mentioned structures and remove the medial neck preparation. Careful hemostasis and H2O2 irrigation. Now dissection on the right side, essentially identical. Here too, the accessorius nerve, the hypoglossal nerve, the cervical sinus and the cervical vascular sheath can be located and spared. After removal of the lateral and medial neck specimen in regions I to V, careful hemostasis, H2O2 irrigation and insertion of a Redon drain are performed. Subsequently, two-layer wound closure. Now perform the tracheotomy. Skin incision. Subcutaneous preparation of the prelaryngeal musculature. Push them apart in the midline. Dissection of the thyroid gland. Undermining of the thyroid gland, clamping, severing and repositioning of both thyroid globules. Now locate the 2nd and 3rd tracheal cartilage. Creation of a Björk flap with the 3rd tracheal cartilage. Epithelialization of the stoma. Now the intubation is transferred to an LE tube. Then lift the radial flap by cutting around the skin island. Locate the radial artery. Clamp it with the bulldog and observe the saturation while the flap pedicle is dissected from caudal to cranial. Locate the flap pedicle in the crook of the elbow. A relatively small artery and even finer veins can be seen. Therefore, renewed demonstration on and . Decision to lift and use the flap despite difficult conditions. Separation of the radial artery caudally and cranially. Subsequent transection of the same. Now separation of the vein. Dissection of the same. Now lift the split skin from the right groin. This is primarily closed by inserting a Redon drain. The split skin is sutured into the lifting defect of the forearm, the rest of the forearm is closed in two layers accordingly. The flap is then fitted into the lifting defect orally. Suturing in the area of the soft palate and the tonsil and caudally with covering of the exposed bone. Passing the flap pedicle through an artificial fistula between the mandible and the submandibular gland. Then dissection of the superior thyroid artery and the internal jugular vein in preparation for anastomization. The thyroid artery is then removed and an end-to-end anastomosis of the superior thyroid artery to the radial artery is performed. Then end-to-side anastomosis of the accompanying veins in their confluence with the internal jugular vein. This is achieved without any problems using 9/0 sutures as microsurgical re-anastomization. Finally, two-layer wound closure with insertion of a Redon drain on the left side of the neck and completion of the procedure with a vital flap and no indication of complications. \ No newline at end of file diff --git a/312/InvasionFront_CD3_block19_x5_y11_patient312_0.json b/312/InvasionFront_CD3_block19_x5_y11_patient312_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6fed7ad4ca5246093f987184f02c5ba9916c505a --- /dev/null +++ b/312/InvasionFront_CD3_block19_x5_y11_patient312_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15816.6, + "Centroid Y µm": 29709.3, + "Num Detections": 21402, + "Num Negative": 21186, + "Num Positive": 216, + "Positive %": 1.009, + "Num Positive per mm^2": 110.27 + } +} \ No newline at end of file diff --git a/312/InvasionFront_CD3_block19_x6_y11_patient312_1.json b/312/InvasionFront_CD3_block19_x6_y11_patient312_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6006d75989576db3492584c4bd18a9c3eb1c7bfa --- /dev/null +++ b/312/InvasionFront_CD3_block19_x6_y11_patient312_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18240.3, + "Centroid Y µm": 29984.1, + "Num Detections": 23782, + "Num Negative": 23539, + "Num Positive": 243, + "Positive %": 1.022, + "Num Positive per mm^2": 115.99 + } +} \ No newline at end of file diff --git a/312/InvasionFront_CD8_block19_x5_y11_patient312_0.json b/312/InvasionFront_CD8_block19_x5_y11_patient312_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9993fc4b52c475a0cb7426a16153566af51b6c41 --- /dev/null +++ b/312/InvasionFront_CD8_block19_x5_y11_patient312_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16116.5, + "Centroid Y µm": 37580.1, + "Num Detections": 16737, + "Num Negative": 16545, + "Num Positive": 192, + "Positive %": 1.147, + "Num Positive per mm^2": 107.27 + } +} \ No newline at end of file diff --git a/312/InvasionFront_CD8_block19_x6_y11_patient312_1.json b/312/InvasionFront_CD8_block19_x6_y11_patient312_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a4e761c1083b8a3627293d179e1a15185c2ac3ed --- /dev/null +++ b/312/InvasionFront_CD8_block19_x6_y11_patient312_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 37730.0, + "Num Detections": 17284, + "Num Negative": 17074, + "Num Positive": 210, + "Positive %": 1.215, + "Num Positive per mm^2": 114.53 + } +} \ No newline at end of file diff --git a/312/TumorCenter_CD3_block19_x5_y11_patient312_0.json b/312/TumorCenter_CD3_block19_x5_y11_patient312_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c9a09b8921232fba428cd315b9f8f85e50ed311d --- /dev/null +++ b/312/TumorCenter_CD3_block19_x5_y11_patient312_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18573.5, + "Centroid Y µm": 27872.5, + "Num Detections": 10352, + "Num Negative": 9989, + "Num Positive": 363, + "Positive %": 3.507, + "Num Positive per mm^2": 235.55 + } +} \ No newline at end of file diff --git a/312/TumorCenter_CD3_block19_x6_y11_patient312_1.json b/312/TumorCenter_CD3_block19_x6_y11_patient312_1.json new file mode 100644 index 0000000000000000000000000000000000000000..132ad9e82086b2aa91ca08a417e40fd5702590d3 --- /dev/null +++ b/312/TumorCenter_CD3_block19_x6_y11_patient312_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20952.1, + "Centroid Y µm": 27611.1, + "Num Detections": 15684, + "Num Negative": 15127, + "Num Positive": 557, + "Positive %": 3.551, + "Num Positive per mm^2": 315.64 + } +} \ No newline at end of file diff --git a/312/TumorCenter_CD8_block19_x5_y11_patient312_0.json b/312/TumorCenter_CD8_block19_x5_y11_patient312_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a565e2e6a687e59576d2467ba32d68245626e562 --- /dev/null +++ b/312/TumorCenter_CD8_block19_x5_y11_patient312_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 38829.4, + "Num Detections": 16596, + "Num Negative": 16290, + "Num Positive": 306, + "Positive %": 1.844, + "Num Positive per mm^2": 164.31 + } +} \ No newline at end of file diff --git a/312/TumorCenter_CD8_block19_x6_y11_patient312_1.json b/312/TumorCenter_CD8_block19_x6_y11_patient312_1.json new file mode 100644 index 0000000000000000000000000000000000000000..59c80d2d1438e545ebf4a798da626ef83c4d3b91 --- /dev/null +++ b/312/TumorCenter_CD8_block19_x6_y11_patient312_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21213.8, + "Centroid Y µm": 38904.4, + "Num Detections": 16151, + "Num Negative": 15899, + "Num Positive": 252, + "Positive %": 1.56, + "Num Positive per mm^2": 137.78 + } +} \ No newline at end of file diff --git a/312/history_text.txt b/312/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..cabce1ea8dfe666a111d27b9904348ae14ad9ca4 --- /dev/null +++ b/312/history_text.txt @@ -0,0 +1 @@ +The patient has been suffering from hoarseness for over a quarter of a year. ENT examination and initiation of a panendoscopy. The panendoscopy revealed a tumor located mainly supraglottically, infiltrating primarily the left-sided pocket fold and spreading to the vocal fold, reaching the anterior commissure and also spreading to the right side. The main tumor mass grows submucosally. The tumor masses reach the left arytenoid cartilage. Due to the age and extent of the tumor, indication for the above-mentioned procedure. \ No newline at end of file diff --git a/312/icd_codes.txt b/312/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/312/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/312/ops_codes.txt b/312/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..969510b4b1f53e1372db38b24b0b9c2c9054d08f --- /dev/null +++ b/312/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Permanente Tracheotomie[5-312.0 ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie mit Rekonstruktion mit lokaler Schleimhaut[5-295.11 ] \ No newline at end of file diff --git a/312/patient_clinical_data.json b/312/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..354dbdde2d71ecffa75503b2fade25df2d3b750f --- /dev/null +++ b/312/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 75, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 63, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/312/patient_pathological_data.json b/312/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..94e88d4ca2d393c05446f1fd158a95bfdab0a6b9 --- /dev/null +++ b/312/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "312", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/312/surgery_description.txt b/312/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c6a01e51d32816ab90214991ab34ecf7a5a9f80f --- /dev/null +++ b/312/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Tracheotomy, Provox placement diff --git a/312/surgery_report.txt b/312/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..df1326470e99adb9937b0f66bd6562651d7ddfcd --- /dev/null +++ b/312/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia. Sterile washing and draping. Prior to this, the pharyngeal and laryngeal areas were inspected again with the small bore tube and the findings from the previous panendoscopy were confirmed. Creation of an apron flap and preparation of the platysma in the usual manner. Then start with the neck dissection on the left side. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and the submandibular gland. Exposure of the cervical vascular sheath and removal of the neck levels II a to V a while sparing the plexus branches. Furthermore, the accessorius nerve and the hypoglossal nerve as well as the cervical sinus are spared. Unfortunately, the facial vein must be removed. Then release the hyoid bone on this side. Dissect the cervical vascular sheath from the pharyngeal and laryngeal area. Detach the thyroid gland from the larynx and turn to the opposite side. Similar procedure here. Exposure of the sternocleidomastoid muscle and exposure of the submandibular gland and the omohyoid muscle. Detachment of the cervical vascular sheath from the larynx. Release of the hyoid bone and detachment of the thyroid gland from the larynx. Dissection of the anterior wall of the trachea and creation of a tracheotomy between the 2nd and 3rd tracheal cartilage. Creation of a mucocutaneous anastomosis in the caudal region. Release of the piriform sinus on the right side and also on the left side. This is only possible to a very limited extent on the left side, as tumor infiltration can already be felt here. Now palpate the pre-epiglottic fatty tissue and localize the epiglottis. Entry into the right paramedian pharynx. Incision of the mucosa along the edges of the epiglottis up to the postcricoid region. Detachment of the larynx from the pharynx and placement of the larynx below the cricoid cartilage. A marginal sample is taken in the area of the pharyngeal side wall towards the soft tissue, as the tumor was resected very close to the healthy tissue here. The edge sample is diagnosed as tumor-free by the pathologist. Now completion of the neck dissection on the right side. Free dissection of the internal jugular vein and removal of the level IIa to IV neck specimen while sparing the plexus branches. Accessory nerve, hypoglossal nerve and facial vein are also spared on this side. The superior thyroid artery is present on the right side. It must be severed on the left side. Now insert a size 6 Provox prosthesis (model no. 2). Perform a two-layer pharyngeal suture in the usual manner using single button sutures. Finally, reduction of the attachments of the sternocleidomastoid muscle in the caudal region and retraction of the apron flap and formation of an epithelialized tracheostoma. Insertion of 2 Redon drains and skin suture in two layers. Please feed via the inserted nasogastric tube for 10 postoperative days, then carry out an X-ray pap-swallow examination and dietary reconstruction and present the patient to the tumor conference after receiving the histology. Continue antibiotics for 24 hours. \ No newline at end of file diff --git a/313/InvasionFront_CD3_block17_x3_y2_patient313_0.json b/313/InvasionFront_CD3_block17_x3_y2_patient313_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f3bd8f1ba6d8ef53641f2ed82679bdb12a8b0707 --- /dev/null +++ b/313/InvasionFront_CD3_block17_x3_y2_patient313_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 10044.7, + "Num Detections": 22756, + "Num Negative": 22379, + "Num Positive": 377, + "Positive %": 1.657, + "Num Positive per mm^2": 148.22 + } +} \ No newline at end of file diff --git a/313/InvasionFront_CD3_block17_x4_y2_patient313_1.json b/313/InvasionFront_CD3_block17_x4_y2_patient313_1.json new file mode 100644 index 0000000000000000000000000000000000000000..54602a0f78869330376c0dba642f4e3a31de8f1d --- /dev/null +++ b/313/InvasionFront_CD3_block17_x4_y2_patient313_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 10219.6, + "Num Detections": 15144, + "Num Negative": 13861, + "Num Positive": 1283, + "Positive %": 8.472, + "Num Positive per mm^2": 591.13 + } +} \ No newline at end of file diff --git a/313/InvasionFront_CD8_block17_x3_y2_patient313_0.json b/313/InvasionFront_CD8_block17_x3_y2_patient313_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c974062ed5ec12b3a6f0ce9beb99f1cde5e5cc9e --- /dev/null +++ b/313/InvasionFront_CD8_block17_x3_y2_patient313_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11244.0, + "Centroid Y µm": 5372.2, + "Num Detections": 21130, + "Num Negative": 20495, + "Num Positive": 635, + "Positive %": 3.005, + "Num Positive per mm^2": 239.29 + } +} \ No newline at end of file diff --git a/313/InvasionFront_CD8_block17_x4_y2_patient313_1.json b/313/InvasionFront_CD8_block17_x4_y2_patient313_1.json new file mode 100644 index 0000000000000000000000000000000000000000..428e2dbf9e238a164add82c8fe2df248740586fe --- /dev/null +++ b/313/InvasionFront_CD8_block17_x4_y2_patient313_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 5272.2, + "Num Detections": 19214, + "Num Negative": 18291, + "Num Positive": 923, + "Positive %": 4.804, + "Num Positive per mm^2": 342.17 + } +} \ No newline at end of file diff --git a/313/TumorCenter_CD3_block17_x3_y2_patient313_0.json b/313/TumorCenter_CD3_block17_x3_y2_patient313_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ac836e063b5a92342c6a701a9a75111bd00d671 --- /dev/null +++ b/313/TumorCenter_CD3_block17_x3_y2_patient313_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 4947.4, + "Num Detections": 20561, + "Num Negative": 19560, + "Num Positive": 1001, + "Positive %": 4.868, + "Num Positive per mm^2": 400.07 + } +} \ No newline at end of file diff --git a/313/TumorCenter_CD3_block17_x4_y2_patient313_1.json b/313/TumorCenter_CD3_block17_x4_y2_patient313_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d38039b51c2b2a250e603160251b7138428bd1cb --- /dev/null +++ b/313/TumorCenter_CD3_block17_x4_y2_patient313_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 4972.4, + "Num Detections": 21702, + "Num Negative": 17279, + "Num Positive": 4423, + "Positive %": 20.38, + "Num Positive per mm^2": 1672.4 + } +} \ No newline at end of file diff --git a/313/TumorCenter_CD8_block17_x3_y2_patient313_0.json b/313/TumorCenter_CD8_block17_x3_y2_patient313_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5d15534cd1b509b03af78502023134a4fdf6dae0 --- /dev/null +++ b/313/TumorCenter_CD8_block17_x3_y2_patient313_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13630.3, + "Centroid Y µm": 18652.6, + "Num Detections": 19964, + "Num Negative": 19293, + "Num Positive": 671, + "Positive %": 3.361, + "Num Positive per mm^2": 285.21 + } +} \ No newline at end of file diff --git a/313/TumorCenter_CD8_block17_x4_y2_patient313_1.json b/313/TumorCenter_CD8_block17_x4_y2_patient313_1.json new file mode 100644 index 0000000000000000000000000000000000000000..130f56fe65414952214a370e5f89f6955e882bd5 --- /dev/null +++ b/313/TumorCenter_CD8_block17_x4_y2_patient313_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16203.9, + "Centroid Y µm": 18527.7, + "Num Detections": 20241, + "Num Negative": 16887, + "Num Positive": 3354, + "Positive %": 16.57, + "Num Positive per mm^2": 1354.9 + } +} \ No newline at end of file diff --git a/313/history_text.txt b/313/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e94071a6587817b4671e7cf3f1cf80ff2df658b0 --- /dev/null +++ b/313/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the larynx on both sides. The above-mentioned surgery was therefore indicated and laser resection was planned if the condition was well controlled. \ No newline at end of file diff --git a/313/icd_codes.txt b/313/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10623317f12e2cf8eb61e998e27f4b464b164dc5 --- /dev/null +++ b/313/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] \ No newline at end of file diff --git a/313/ops_codes.txt b/313/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0bfb95bbbcf685da65ca4356b64a54a39998085a --- /dev/null +++ b/313/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] Wechsel eines Platzhalters nach Larynxrekonstruktion[5-319.3 ] \ No newline at end of file diff --git a/313/patient_clinical_data.json b/313/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..75283f594ecdf551d56512c1036332263ffedc72 --- /dev/null +++ b/313/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/313/patient_pathological_data.json b/313/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5fc7bd9c93f7df1cac9a9ee479547983829964cf --- /dev/null +++ b/313/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "313", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/313/surgery_description.txt b/313/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..91cd96297bef83d2cb07aca0840522e756b815eb --- /dev/null +++ b/313/surgery_description.txt @@ -0,0 +1 @@ +Laser resection of glottis diff --git a/313/surgery_report.txt b/313/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..973773b7738aefb276d1dbfdfce7dfe501da81cf --- /dev/null +++ b/313/surgery_report.txt @@ -0,0 +1 @@ +First, insertion of the Kleinsasser tube size C again after insertion of the mouthguard and assessment of the tumor. The exophytic tumor, which begins just before the ary on the right, is initially relatively flat, but then becomes significantly thicker and grows towards the supra- and subglottic area until it reaches the anterior commissure, also carcinoma on the opposite side, which could probably be a second separate tumor, because the mucosa directly in the anterior commissure appears to be inconspicuous over a very small area. This tumor also extends to just before the arytenoid region and is clearly thickened in the middle area, in contrast to the right side, where it is thickened in the middle to anterior area. Flat tumor in the dorsal area on the left. First resection of the tumor starting in the anterior commissure, here pushing the tumor away from the cartilage or also below from the area of the ligamentum conicum or up to the cricoid cartilage. Dorsally, the tumor is also resected on all sides with a safety margin of approx. 4 mm, whereby partial muscle tissue is still preserved dorsally, approaching the cartilage cranially, and resection up to the cartilage level at the very front. The tumor is also resected from the left dorsal side, whereby the tumor runs flat on the left dorsal side, mucosa with some soft tissue is resected here so that the muscles are largely preserved, with increasing resection of the soft tissue towards the front until the cartilage is reached again at the very front. The tumor is removed in its entirety and marked basally with sutures. Subsequently, supraglottic and subglottic anterior, supraglottic right and left, subglottic right and left, ary right and left marginal samples are taken. All marginal samples are sent for frozen section. No infiltrates visible in the frozen section, therefore R0 resection. There is still a remnant of soft tissue and vocal fold on both sides. Exposed cartilage or ring cartilage in the front. Therefore, insertion of a Dacron foil, which is fixed in the typical manner using sutures, which are passed outwards and knotted on the outside using a horizontal button. Check the position again. Good position of the Dacron foil. The hemostasis that was previously performed is now performed again. No evidence of bleeding on completion. A tracheostomy can be avoided despite the relatively extensive resection, with overall good adjustability and good intubation. No respiratory distress or dysphagia to be expected. Completion of the procedure without complications. Patient received clindamycin preoperatively. Please continue the antibiotic treatment for one week if the cartilage is exposed at the front. Please leave the Dacron foil in place for 6-8 weeks, preferably removing it at the next MLE check-up after approx. 8 weeks. Wait for the final histology. Patient goes to intensive care unit for one night for monitoring. \ No newline at end of file diff --git a/314/InvasionFront_CD3_block11_x1_y12_patient314_0.json b/314/InvasionFront_CD3_block11_x1_y12_patient314_0.json new file mode 100644 index 0000000000000000000000000000000000000000..53c079c35225efef36adadbb63878f4449bcbccc --- /dev/null +++ b/314/InvasionFront_CD3_block11_x1_y12_patient314_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 29034.6, + "Num Detections": 9382, + "Num Negative": 9305, + "Num Positive": 77, + "Positive %": 0.8207, + "Num Positive per mm^2": 56.9 + } +} \ No newline at end of file diff --git a/314/InvasionFront_CD3_block11_x2_y12_patient314_1.json b/314/InvasionFront_CD3_block11_x2_y12_patient314_1.json new file mode 100644 index 0000000000000000000000000000000000000000..91dca60de0483f9d358db45478866368fc149982 --- /dev/null +++ b/314/InvasionFront_CD3_block11_x2_y12_patient314_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 28909.7, + "Num Detections": 15306, + "Num Negative": 14553, + "Num Positive": 753, + "Positive %": 4.92, + "Num Positive per mm^2": 434.59 + } +} \ No newline at end of file diff --git a/314/InvasionFront_CD8_block11_x1_y12_patient314_0.json b/314/InvasionFront_CD8_block11_x1_y12_patient314_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f6b9dae6c131b1b5b96e130da168b3fbc7d30541 --- /dev/null +++ b/314/InvasionFront_CD8_block11_x1_y12_patient314_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6553.9, + "Centroid Y µm": 40296.6, + "Num Detections": 11408, + "Num Negative": 11356, + "Num Positive": 52, + "Positive %": 0.4558, + "Num Positive per mm^2": 35.75 + } +} \ No newline at end of file diff --git a/314/InvasionFront_CD8_block11_x2_y12_patient314_1.json b/314/InvasionFront_CD8_block11_x2_y12_patient314_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c738de607c015980e38fb1617eaba180ab228756 --- /dev/null +++ b/314/InvasionFront_CD8_block11_x2_y12_patient314_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9161.2, + "Centroid Y µm": 40177.3, + "Num Detections": 14582, + "Num Negative": 14291, + "Num Positive": 291, + "Positive %": 1.996, + "Num Positive per mm^2": 170.95 + } +} \ No newline at end of file diff --git a/314/TumorCenter_CD3_block11_x1_y12_patient314_0.json b/314/TumorCenter_CD3_block11_x1_y12_patient314_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dd7733a24994451af20eba1df44c46d1d073be84 --- /dev/null +++ b/314/TumorCenter_CD3_block11_x1_y12_patient314_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 29109.6, + "Num Detections": 21474, + "Num Negative": 21003, + "Num Positive": 471, + "Positive %": 2.193, + "Num Positive per mm^2": 201.53 + } +} \ No newline at end of file diff --git a/314/TumorCenter_CD3_block11_x2_y12_patient314_1.json b/314/TumorCenter_CD3_block11_x2_y12_patient314_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1875de09c2e7a500a08bd4193612666a6b677ef0 --- /dev/null +++ b/314/TumorCenter_CD3_block11_x2_y12_patient314_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8495.5, + "Centroid Y µm": 29359.5, + "Num Detections": 23517, + "Num Negative": 23057, + "Num Positive": 460, + "Positive %": 1.956, + "Num Positive per mm^2": 186.61 + } +} \ No newline at end of file diff --git a/314/TumorCenter_CD8_block11_x1_y12_patient314_0.json b/314/TumorCenter_CD8_block11_x1_y12_patient314_0.json new file mode 100644 index 0000000000000000000000000000000000000000..59491dede2ebff07f167cccfa5fafb7f4645acf6 --- /dev/null +++ b/314/TumorCenter_CD8_block11_x1_y12_patient314_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 29359.5, + "Num Detections": 23243, + "Num Negative": 22877, + "Num Positive": 366, + "Positive %": 1.575, + "Num Positive per mm^2": 144.9 + } +} \ No newline at end of file diff --git a/314/TumorCenter_CD8_block11_x2_y12_patient314_1.json b/314/TumorCenter_CD8_block11_x2_y12_patient314_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1907b12d94535888b4e7ae5fe4c4060e149ac870 --- /dev/null +++ b/314/TumorCenter_CD8_block11_x2_y12_patient314_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6246.7, + "Centroid Y µm": 29434.4, + "Num Detections": 23520, + "Num Negative": 23132, + "Num Positive": 388, + "Positive %": 1.65, + "Num Positive per mm^2": 150.83 + } +} \ No newline at end of file diff --git a/314/history_text.txt b/314/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..285a6898fbc89297acf08cf2605ec8bcc3301141 --- /dev/null +++ b/314/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT3-cT4 hypopharyngeal carcinoma on the left, additionally confirmed cT1 carcinoma of the arytenoid region on the right. Therefore, the above-mentioned surgery was indicated. \ No newline at end of file diff --git a/314/icd_codes.txt b/314/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..25c1977711ae78f33446bcb88b9f32a54b1e3d42 --- /dev/null +++ b/314/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] Sekundäre und nicht näher bezeichnete bösartige Neubildung: Lymphknoten des Kopfes, des Gesichtes und des Halses[C77.0 ] \ No newline at end of file diff --git a/314/ops_codes.txt b/314/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..346a3b6e560b2a22650fa2cdd3ffce77d409e080 --- /dev/null +++ b/314/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.14 ] Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Sonstige Hemilaryngektomie[5-301.x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Transplantation sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.98 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/314/patient_clinical_data.json b/314/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..971a90127f77dd8ce3f752e10a0743d4e80a5f11 --- /dev/null +++ b/314/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 45, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/314/patient_pathological_data.json b/314/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b0fcb9dff3085d398bfdcc1257d120d0c4cfeda9 --- /dev/null +++ b/314/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "314", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "pN3", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 13.0, + "number_of_resected_lymph_nodes": 55, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/314/surgery_description.txt b/314/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4a7c09ac0914898d3840fb853518e4d2c832b9f9 --- /dev/null +++ b/314/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheostomy, Defect coverage, Free flap (ALT) diff --git a/314/surgery_report.txt b/314/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8963c37ef5748cd9ba42058ce883802caf7649c3 --- /dev/null +++ b/314/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again: The described, deeply exulcerating tumor in the hypopharynx on the left is visible, which grows up to the arytenoid fold on the left and involves the hypopharyngeal side wall and extends under the tonsillar lobe in the hypopharynx. On the other side, the flat, papillomatous tumor in the arytenoid region on the right is visible. The above-mentioned indication for surgery was confirmed. First skin disinfection. Injection of a total of 15 ml xylocaine 1% with adrenaline into both sides of the neck. Sterile draping. Radical neck dissection on the left follows: Skin incision in the typical manner along the sternocleidomastoid muscle. Extension at a 90° angle in the direction of the submandibular lobe. Subsequent exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle, exposure of the digastric muscle. Exposure of the cervical vascular sheath, internal jugular artery, internal and external carotid artery, vagus nerve, boundary cord of the accessorius nerve and hypoglossal nerve. There is a large conglomerate of lymph nodes extending from caudal to cranial lateral to the cervical vascular sheath. It infiltrates the sternocleidomastoid muscle, the internal jugular vein and branches of the cervical plexus in the upper area. The internal jugular vein is dissected cranially and caudally from the tumor, is not affected here and is ligated twice. A caudal outlet remains in the direction of the thyroid gland. Cranial also double ligation. The internal carotid artery can be completely dissected. Caudal exposure of the thoracic duct or a large lymphatic vessel in the venous angle, which is ligated twice. The conglomerate is then removed laterally from the cervical vascular sheath, including the sternocleidomastoid muscle, the internal jugular vein, the accessorius nerve and resection of the upper cervical plexus branches. Parts of the prevertebral, paravertebral musculature must also be removed. Here in the area of the strongest adherence of the lymph node preparation, marginal samples are taken, also from the upper end of the separated internal jugular vein. Both marginal samples are sent for frozen section. No tumor infiltrates here in the frozen section. All soft tissues, including parts of the trapezius muscle, were resected. Subsequent clearing of levels Ib and Ia, including the submandibular gland. Exposure and preservation of the hypoglossal nerve and lingual nerve. Also preservation of the facial artery. Subsequent tumor resection: First exposure of the hyoid bone from the lateral or superior cornu. Insertion between hyoid bone and superior cornu. Exposure of the tumor. The tumor is incised on all sides with a safety margin of 1 to 1.5 cm. The entire lateral hypopharyngeal side wall and the posterior hypopharyngeal wall are removed; resection extends up to the base of the tongue and under the tonsillar lobe. Resection extends from the vallecula, next to the epiglottis downwards, including the aryepiglottic fold and the piriform sinus to the tip of the piriformis. The tumor is macroscopically removed from the healthy tissue and is thread-marked for frozen section. To be on the safe side, a lateral specimen is taken adjacent to the epiglottis, including parts of the base of the tongue and the cranial resection margin. In the frozen section, infiltrates in the lateral and cranial direction in the sense of a microinvasive carcinoma or carcinoma in situ infiltrates. Therefore, resection laterally and cranially and removal of a marginal sample from the lateral, divided into lateral and caudal, including the remains of the arytenoid fold or the mucosa towards the postcricoid region and including further lateral parts of the epiglottis and vallecula region. Also resection again cranially and removal of a marginal sample, which extends from the base of the tongue over the lateral pharyngeal wall to the cranial border in the oropharynx. The frozen section is now free laterally, but there are still in situ infiltrates cranially. Therefore, another extensive resection of a wide mucosal strip is performed cranially. The marginal samples are taken transorally by inserting a Mc Ivor spatula. For this purpose, a cranial mucosal strip of the residual mucosa, which is already located behind the uvula, is removed as well as the residual tonsil and a strip from the side wall of the pharynx. All these marginal samples are sent to the frozen section again as a cranial marginal sample. No more tumor infiltrates here. Therefore, an R0 resection can now be assumed. Subsequently, resection of the 2nd carcinoma in the area of the arytenoid hump on the right. This is a flat, papillomatous carcinoma. This is macroscopically incised on all sides with a safety margin of several millimeters in healthy tissue and sent for frozen section examination with a suture marker. Here in the dorsal and lateral area still carcinoma in situ. Therefore, resection of the dorsal and lateral areas and removal of representative marginal samples. These are now tumor-free. Thus an R0 situation here too. However, extensive hypopharyngeal carcinoma with in situ can be assumed in the case of suspected field carcinoma and a second carcinoma in the case of suspected polycentric carcinoma. The residual mucosa in the postcricoid area is now readapted cranially as far as possible in order to achieve improved sensitivity and mucosal coverage using 5/0 Vicryl sutures. During the tumor resection, a plastic tracheostoma was created by reopening in the case of a post-dilatation tracheostomy. The old scar was reopened in the cranial region, the trachea was exposed and epithelialized in the 2nd and 3rd intercartilage space in a typical manner using a wide pedicle Björk flap. Insertion of a laryngectomy tube. Following the tumor resection Neck dissection on the right: Level II to IV as well as larger parts of V. Multiple suspicious nodes are also removed here. The internal jugular vein, internal/external carotid artery, vagus nerve, accessorius nerve, hypoglossal nerve, border cord and the branches of the cervical plexus were preserved here, as was the superior thyroid artery. A femoral flap was then removed from the left side to cover the defect. After measuring the defect, which required a size of 12 x 8 cm, a flap size of 17 x 8 cm was measured, as the flap is to be lifted with a skin island as a monitor. Several perforators can be displayed. The flap is outlined around the perforators. First cut medially through the skin and subcutis to the fascia. Dissect below the fascia up to the intermuscular septum. Widen the incision cranially and expose the vascular pedicle of the descending ramus. Also expose the perforators, which all extend through the musculature. The vascular pedicle is exposed up to the exit from the profunda femoris artery. Here the artery reaches a good thickness. Equally good venous confluence can be visualized. The flap is then incised laterally. After cutting through the fascia, a larger part of the vastus lateralis muscle is resected with the intermuscular course of the perforators, particularly in the caudal region. Outgoing branches are bipolarly coagulated or treated with a clip. The vascular pedicle is placed directly on the profunda femoris artery. Good reflux from the superficial circumflex iliac artery, which must be removed due to the anatomical conditions at the flap stalk. The associated veins are also removed. The vascular pedicle is then removed. All arteries and veins are supplied using 4/0 Prolene puncture ligatures. Flap is rinsed with heparin and preserved. The thigh wound is closed in layers after careful hemostasis and insertion of a Redon drain. The flap is then inserted into the defect and sutured into the defect without tension after the sutures have been placed. An approx. 5 cm wide, de-epithelialized bridge to a skin monitor was created in the caudal area. The defect was closed completely and with minimal tension. The vessels are connected after trimming and conditioning of the vessels. An end-to-end anastomosis is made between the superior thyroid artery, which was preserved during the radical neck dissection, and the descending ramus with 8/0 ethilon sutures. This is followed by the anastomosis between the main venous drainage vessel and the external jugular vein, which was also preserved during the neck dissection. A size 3/5 coupler is used for this. After arterial anastomosis good venous return via the vein, after venous anastomosis good venous return. Flap vital. This is followed by careful hemostasis. Overall, hemostasis is sometimes very difficult during the operation as there is constant and diffuse bleeding from the various tissue sections due to coagulation disorders. Skin closure of the neck wound on the right is achieved without any problems by inserting a Redon drain. Skin closure of the wound on the left with insertion of the skin monitor. However, due to the increased tissue tension in the middle area, a small portion of the skin remains unsutured to prevent compression of the flap. A flap was inserted on the left. The laryngectomy tube is replaced by a tracheostomy tube with a core, which is fixed with sutures. The procedure is completed without complications. Patient goes to the intensive care unit for monitoring. Overall, due to continuous bleeding with impaired coagulation, need for blood reserves and coagulation factors. At the end of the operation, the jugular vein was easy to check with the Doppler at the marked site. The skin monitor was vital. Postoperatively, please continue antibiotics with Unacid i.v.. Feeding via the previously inserted PEG tube. Food build-up after swallowing porridge on the 10th day with unremarkable findings. The still dehisced wound area on the left cervical side can be closed secondarily after the swelling has subsided. Please carry out regular Doppler checks of the monitor postoperatively according to the scheme. Postoperative radio-chemotherapy is certainly necessary for mulicentric hypopharyngeal carcinoma and field cancerization. \ No newline at end of file diff --git a/315/InvasionFront_CD3_block19_x3_y9_patient315_0.json b/315/InvasionFront_CD3_block19_x3_y9_patient315_0.json new file mode 100644 index 0000000000000000000000000000000000000000..939d5720650dd9ed4dea78a8cc1f628397ac84a9 --- /dev/null +++ b/315/InvasionFront_CD3_block19_x3_y9_patient315_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11593.9, + "Centroid Y µm": 24462.0, + "Num Detections": 14627, + "Num Negative": 14113, + "Num Positive": 514, + "Positive %": 3.514, + "Num Positive per mm^2": 319.05 + } +} \ No newline at end of file diff --git a/315/InvasionFront_CD3_block19_x4_y9_patient315_1.json b/315/InvasionFront_CD3_block19_x4_y9_patient315_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f4f0943abe3d68ae8ff76ba89016c5cc36adb40e --- /dev/null +++ b/315/InvasionFront_CD3_block19_x4_y9_patient315_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 24836.8, + "Num Detections": 16746, + "Num Negative": 15544, + "Num Positive": 1202, + "Positive %": 7.178, + "Num Positive per mm^2": 669.96 + } +} \ No newline at end of file diff --git a/315/InvasionFront_CD8_block19_x3_y9_patient315_0.json b/315/InvasionFront_CD8_block19_x3_y9_patient315_0.json new file mode 100644 index 0000000000000000000000000000000000000000..33ffbf9cf4246a6abe225956826f5cb7923c9f30 --- /dev/null +++ b/315/InvasionFront_CD8_block19_x3_y9_patient315_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11369.0, + "Centroid Y µm": 32307.9, + "Num Detections": 24273, + "Num Negative": 23750, + "Num Positive": 523, + "Positive %": 2.155, + "Num Positive per mm^2": 200.98 + } +} \ No newline at end of file diff --git a/315/InvasionFront_CD8_block19_x4_y9_patient315_1.json b/315/InvasionFront_CD8_block19_x4_y9_patient315_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6452d6f7701a84dfeb5dea32b571cb6750c0a929 --- /dev/null +++ b/315/InvasionFront_CD8_block19_x4_y9_patient315_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 32457.8, + "Num Detections": 19069, + "Num Negative": 18536, + "Num Positive": 533, + "Positive %": 2.795, + "Num Positive per mm^2": 246.96 + } +} \ No newline at end of file diff --git a/315/TumorCenter_CD3_block19_x3_y9_patient315_0.json b/315/TumorCenter_CD3_block19_x3_y9_patient315_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08009e24a41557d70777f16b0fb30662a417bf53 --- /dev/null +++ b/315/TumorCenter_CD3_block19_x3_y9_patient315_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12941.3, + "Centroid Y µm": 23548.0, + "Num Detections": 11732, + "Num Negative": 10144, + "Num Positive": 1588, + "Positive %": 13.54, + "Num Positive per mm^2": 817.35 + } +} \ No newline at end of file diff --git a/315/TumorCenter_CD3_block19_x4_y9_patient315_1.json b/315/TumorCenter_CD3_block19_x4_y9_patient315_1.json new file mode 100644 index 0000000000000000000000000000000000000000..75ebc37233ff6af48349e0b849353fd6afb9efd9 --- /dev/null +++ b/315/TumorCenter_CD3_block19_x4_y9_patient315_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15516.8, + "Centroid Y µm": 23312.7, + "Num Detections": 14440, + "Num Negative": 13318, + "Num Positive": 1122, + "Positive %": 7.77, + "Num Positive per mm^2": 530.14 + } +} \ No newline at end of file diff --git a/315/TumorCenter_CD8_block19_x3_y9_patient315_0.json b/315/TumorCenter_CD8_block19_x3_y9_patient315_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b5f71988dd890292b29ff4de0e52b3fc74d4a94 --- /dev/null +++ b/315/TumorCenter_CD8_block19_x3_y9_patient315_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 33707.2, + "Num Detections": 20294, + "Num Negative": 19135, + "Num Positive": 1159, + "Positive %": 5.711, + "Num Positive per mm^2": 496.22 + } +} \ No newline at end of file diff --git a/315/TumorCenter_CD8_block19_x4_y9_patient315_1.json b/315/TumorCenter_CD8_block19_x4_y9_patient315_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7d39e33b7b532de6f0def013ed91fc80c3db7e3f --- /dev/null +++ b/315/TumorCenter_CD8_block19_x4_y9_patient315_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 33832.1, + "Num Detections": 17013, + "Num Negative": 16324, + "Num Positive": 689, + "Positive %": 4.05, + "Num Positive per mm^2": 315.17 + } +} \ No newline at end of file diff --git a/315/history_text.txt b/315/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/315/icd_codes.txt b/315/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c90d954d77828b28007714ce5a6bb61d50cc6929 --- /dev/null +++ b/315/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Supraglottis[C32.1 ] \ No newline at end of file diff --git a/315/ops_codes.txt b/315/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bb5be37fd351a0b2bc0f21b8bca990bef7c4c663 --- /dev/null +++ b/315/ops_codes.txt @@ -0,0 +1 @@ +Epiglottektomie endolaryngeal[5-302.0 ] Endoskopische Laserresektion Larynxgewebe[5-302.5 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/315/patient_clinical_data.json b/315/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b75bb73cf9ceb3ab3a99db9dc13337609603de47 --- /dev/null +++ b/315/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 66, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/315/patient_pathological_data.json b/315/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9ae352e4cddae5e0206fa3c3c464122d0b8b0c23 --- /dev/null +++ b/315/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "315", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 32, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/315/surgery_description.txt b/315/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ff204108ebdbec442f4565f3fbfba22e524f3d4 --- /dev/null +++ b/315/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Neck dissection, Tracheotomy diff --git a/315/surgery_report.txt b/315/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d19254bf82df58025c2ad6b175218476316a73f0 --- /dev/null +++ b/315/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Intubation of the patient. The supraglottis is adjusted with the small bore tube. A penetrating defect can be seen at the base of the epiglottis, at the transition to the vallecula. The entire inner surface of the epiglottis is affected by an exophytic tumor, which here occupies the right side somewhat preferentially, but clearly crosses the midline. The support autoscopy is removed and the patient is switched to a spreading laryngoscope. This allows the tumor to be exposed reasonably well. Circular resection is now performed with the CO2 laser. Due to the slightly restricted view, the position of the spreading laryngoscope has to be changed once during the operation. The resection extends over the aryepiglottic fold on the right side into the vallecula and the prelaryngeal fat on both sides. The arytenoid cartilage on the right side is skeletonized on the inside. On the left side, the ary remains completely covered by mucosa and untouched. Due to an infestation of the detachment margin on the right ary, which could not be ruled out, a subsequent resection had to be performed during the operation, which was also sent in for final histological findings, as was the main specimen. Macroscopically, all the margins of the deposit appear free. The caudal margin refers to the pocket fold on the left side across the commissure to the pocket fold on the right side. However, 95% of the pocket folds are preserved. Removal of sedimentation margin samples in the caudal sedimentation area and anteriorly to the pre-epiglottic fat. All the specimens taken from the edge of the sedimentation area are sent for frozen section diagnostics. Here, the intraoperative findings are that there is high-grade dysplasia in the settling margin of the pocket fold on the right side and in the area of the commissure of the pocket folds, which is why the pathologists would recommend a resection here. This is done without any problems after the spreading laryngoscope has been inserted again with the CO2 laser. The new samples taken from the margins are sent for final histopathological diagnosis. If the wound is dry, removal of the spreading laryngoscope and support autoscopy. Repositioning of the patient for neck dissection. First injection of local anesthetic with adrenaline. Then skin incision, initially on the right side on the anterior edge of the sternocleidomastoid muscle. The dissection is performed subcutaneously far ventrally after an atheroma-like change becomes apparent here. This atheroma is removed from the subcutaneous tissue from the inside. A tiny skin injury is primarily treated with a suture. Subsequent layer-by-layer dissection in depth. Exposure and transection of the platysma. Exposure of the anterior edge of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the posterior belly of the digaster muscle. Exposure of the glandular capsule of the submandibular gland. Subsequently, the examination reveals a lymph node conglomerate far caudally and one in the area of the venous angle. Both lymph node conglomerates are dissected laterally down from the cervical vascular sheath after it has been exposed. Exposure of the cervical vascular sheath involves sparing the vagus nerve and all vascular structures. Displacement and, at the end of the operation, re-embedding of the vagus nerve in the sense of a neurolysis. After the lymph node conglomerates have been dissected laterally from the vein, the lateral neck preparation with all easily palpable nodes is removed. This is done while sparing the accessorius nerve. The hypoglossal nerve and accessorius nerve are lifted out of their bed in the sense of a neurolysis and re-embedded after relocation. The accessorius triangle is also removed. Clearing of the hypoglossal triangle and development of the anterior neck preparation. All branches of the internal jugular vein and external carotid artery are also protected. The preparation is sent together for diagnosis. Two-layer wound closure. Insertion of a Redon drainage. Application of a pressure dressing. Repositioning for neck dissection on the left side. This shows a cN0 neck status. Skin incision along the anterior edge of the sternocleidomastoid muscle. Dissection in depth. Dissection of the platysma. Exposure of all landmarks with the omohyoid muscle, the digaster muscle and the submandibular gland. Exposure and opening of the cervical vascular sheath. Long-distance dissection of the vagus nerve, hypoglossal nerve and accessorius nerve. All nerves are lifted out of their bed in the sense of a neurolysis and re-embedded. Release of the accessorius triangle and development of the entire lateral neck preaprate. The hypoglossal triangle is also released and then the entire anterior neck preparation is developed. Here too, the dissection is performed while sparing all branches of the internal jugular vein and external carotid artery. There are no enlarged lymph nodes. The entire preparation is also sent for histopathological examination. Insertion of a Redon drainage. Two-layer wound closure. Application of a pressure dressing. The result is a selective neck dissection of five levels on both sides. Due to the extent of the endolaryngeal resection and the potential swallowing problems to be expected, the decision was made to tracheotomize the patient. This is also performed after injection of local anesthetic with adrenaline pretracheally. Transverse skin incision and layer-by-layer preparation in depth. Exposure of the prelaryngeal and infralaryngeal muscles. This is separated in the middle. Exposure of the thyroid isthmus. This is clamped on both sides, severed and ligated. Exposure of the anterior surface of the trachea. The trachea is then opened between the 2nd and 3rd cartilage clasp. Dissection of the Björ flap. Then circular suturing of the tracheostoma with several holding sutures. Insertion of a tracheostomy tube. Final consultation with the anesthetist. \ No newline at end of file diff --git a/316/InvasionFront_CD3_block5_x3_y11_patient316_0.json b/316/InvasionFront_CD3_block5_x3_y11_patient316_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9922bbc19f87b0295201e7654008ebd07a711cd2 --- /dev/null +++ b/316/InvasionFront_CD3_block5_x3_y11_patient316_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10900.3, + "Centroid Y µm": 27941.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/316/InvasionFront_CD3_block5_x4_y11_patient316_1.json b/316/InvasionFront_CD3_block5_x4_y11_patient316_1.json new file mode 100644 index 0000000000000000000000000000000000000000..213ea02e75421b9424f950e7dc9124fcebf04521 --- /dev/null +++ b/316/InvasionFront_CD3_block5_x4_y11_patient316_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13871.9, + "Centroid Y µm": 28123.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/316/InvasionFront_CD8_block5_x3_y9_patient316_0.json b/316/InvasionFront_CD8_block5_x3_y9_patient316_0.json new file mode 100644 index 0000000000000000000000000000000000000000..82998833033a5eb46447bd9a9c5fc8a0103d18c5 --- /dev/null +++ b/316/InvasionFront_CD8_block5_x3_y9_patient316_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 22513.1, + "Num Detections": 19674, + "Num Negative": 19056, + "Num Positive": 618, + "Positive %": 3.141, + "Num Positive per mm^2": 308.06 + } +} \ No newline at end of file diff --git a/316/InvasionFront_CD8_block5_x4_y9_patient316_1.json b/316/InvasionFront_CD8_block5_x4_y9_patient316_1.json new file mode 100644 index 0000000000000000000000000000000000000000..14f4c44edb828413ac64fc1d51002c0598053551 --- /dev/null +++ b/316/InvasionFront_CD8_block5_x4_y9_patient316_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 22588.0, + "Num Detections": 13527, + "Num Negative": 13479, + "Num Positive": 48, + "Positive %": 0.3548, + "Num Positive per mm^2": 30.53 + } +} \ No newline at end of file diff --git a/316/TumorCenter_CD3_block5_x3_y9_patient316_0.json b/316/TumorCenter_CD3_block5_x3_y9_patient316_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ff57528e09c688d9763619bd793ba68310d21bc4 --- /dev/null +++ b/316/TumorCenter_CD3_block5_x3_y9_patient316_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 22288.2, + "Num Detections": 16965, + "Num Negative": 16910, + "Num Positive": 55, + "Positive %": 0.3242, + "Num Positive per mm^2": 28.3 + } +} \ No newline at end of file diff --git a/316/TumorCenter_CD3_block5_x4_y9_patient316_1.json b/316/TumorCenter_CD3_block5_x4_y9_patient316_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3bd78086b7d782e3260ac0493754910bfb18643c --- /dev/null +++ b/316/TumorCenter_CD3_block5_x4_y9_patient316_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 22613.0, + "Num Detections": 29812, + "Num Negative": 20439, + "Num Positive": 9373, + "Positive %": 31.44, + "Num Positive per mm^2": 3346.1 + } +} \ No newline at end of file diff --git a/316/TumorCenter_CD8_block5_x3_y9_patient316_0.json b/316/TumorCenter_CD8_block5_x3_y9_patient316_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4e1b2f4bfb46e70dedb1fea203c1cc7daa776faa --- /dev/null +++ b/316/TumorCenter_CD8_block5_x3_y9_patient316_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10869.2, + "Centroid Y µm": 22513.1, + "Num Detections": 16895, + "Num Negative": 16858, + "Num Positive": 37, + "Positive %": 0.219, + "Num Positive per mm^2": 18.91 + } +} \ No newline at end of file diff --git a/316/TumorCenter_CD8_block5_x4_y9_patient316_1.json b/316/TumorCenter_CD8_block5_x4_y9_patient316_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d413025a5bfb940d531b75cb5a6e1620c411566 --- /dev/null +++ b/316/TumorCenter_CD8_block5_x4_y9_patient316_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 22613.0, + "Num Detections": 33701, + "Num Negative": 27940, + "Num Positive": 5761, + "Positive %": 17.09, + "Num Positive per mm^2": 2047.5 + } +} \ No newline at end of file diff --git a/316/history_text.txt b/316/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/316/icd_codes.txt b/316/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adab28f0b88ba31c5bb4895a3d4f3034f2967b3e --- /dev/null +++ b/316/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] \ No newline at end of file diff --git a/316/ops_codes.txt b/316/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9f3067f1a8b0d6ae6e3fb86ee52c9cb96fcd33af --- /dev/null +++ b/316/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Transorale Tumortonsillektomie[5-281.2 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/316/patient_clinical_data.json b/316/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3f39a61ea6034a30f023e657a504ea24a69fcc3e --- /dev/null +++ b/316/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/316/patient_pathological_data.json b/316/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c71a11803c8e82f868ca90f3a59e73795b96cf81 --- /dev/null +++ b/316/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "316", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 9.0, + "number_of_resected_lymph_nodes": 21, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/316/surgery_description.txt b/316/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..12f3e2be549e2fa1370dec22b03e5e7d12cdcb58 --- /dev/null +++ b/316/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, PEG placement diff --git a/316/surgery_report.txt b/316/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..77645e771a826a263a53988e9196a86949185a7c --- /dev/null +++ b/316/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Then entry with the Mc Ivor oral spatula and inspection of the tonsil on the right side. An ulcer-like mass was found in the area of the right tonsil, with mucosal changes on the anterior and posterior palatal arches and superficial mucosal changes, even just to the parauvular level. The tumor was then cut around with a safety margin of 0.5 to 1 cm using a monopolar needle. In depth, the tumor must be dissected with bipolar forceps and scissors. In the area of the cranial tonsil pole, the resection extends into the soft tissues of the neck. Neck fat is revealed, then the entire tumor preparation is removed en bloc and deposited at the base of the tongue. The specimen is placed on cork for frozen section. In the area of the cranial tonsil pole, a resection specimen is taken, as the resection margins appear to be very narrow here. This is also thread-marked and placed on cork for a frozen section. Then take a margin sample from the depth in the area of the deepest resection site. In the frozen section all marginal samples are R0, in the area of the median margin of the posterior pharyngeal wall there is still at least moderate dysplasia and in consultation with the pathology department this should be resected again. Therefore, a strip of mucosa is removed here again, which is thread-marked (remote from the tumor) for final histology. During the frozen section break, a PEG was inserted with good diaphanoscopy and without complications. Please plan a second neck dissection on both sides and then present at the tumor conference. \ No newline at end of file diff --git a/317/InvasionFront_CD3_block19_x5_y9_patient317_0.json b/317/InvasionFront_CD3_block19_x5_y9_patient317_0.json new file mode 100644 index 0000000000000000000000000000000000000000..33bad28734dce641c36034e26525d1fee2e9db24 --- /dev/null +++ b/317/InvasionFront_CD3_block19_x5_y9_patient317_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 25036.7, + "Num Detections": 9583, + "Num Negative": 9507, + "Num Positive": 76, + "Positive %": 0.7931, + "Num Positive per mm^2": 70.77 + } +} \ No newline at end of file diff --git a/317/InvasionFront_CD3_block19_x6_y9_patient317_1.json b/317/InvasionFront_CD3_block19_x6_y9_patient317_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f75d970c900ca761400b7faa311fe752156dc9b --- /dev/null +++ b/317/InvasionFront_CD3_block19_x6_y9_patient317_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 25336.6, + "Num Detections": 25700, + "Num Negative": 25523, + "Num Positive": 177, + "Positive %": 0.6887, + "Num Positive per mm^2": 65.19 + } +} \ No newline at end of file diff --git a/317/InvasionFront_CD8_block19_x5_y9_patient317_0.json b/317/InvasionFront_CD8_block19_x5_y9_patient317_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3e2a0c4c645ecfb364baa57f5d5af81ad717eb94 --- /dev/null +++ b/317/InvasionFront_CD8_block19_x5_y9_patient317_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 32657.7, + "Num Detections": 13010, + "Num Negative": 12900, + "Num Positive": 110, + "Positive %": 0.8455, + "Num Positive per mm^2": 70.36 + } +} \ No newline at end of file diff --git a/317/InvasionFront_CD8_block19_x6_y9_patient317_1.json b/317/InvasionFront_CD8_block19_x6_y9_patient317_1.json new file mode 100644 index 0000000000000000000000000000000000000000..32f11215ece6b40ee5e5dab671bca55760c28648 --- /dev/null +++ b/317/InvasionFront_CD8_block19_x6_y9_patient317_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 32757.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/317/TumorCenter_CD3_block19_x5_y9_patient317_0.json b/317/TumorCenter_CD3_block19_x5_y9_patient317_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b7828c791aa6af20be0154f59f0ae61ade3f924c --- /dev/null +++ b/317/TumorCenter_CD3_block19_x5_y9_patient317_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17940.5, + "Centroid Y µm": 23112.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/317/TumorCenter_CD3_block19_x6_y9_patient317_1.json b/317/TumorCenter_CD3_block19_x6_y9_patient317_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9fec720baeefb8d19ddfe01559fa3223248148f4 --- /dev/null +++ b/317/TumorCenter_CD3_block19_x6_y9_patient317_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20564.1, + "Centroid Y µm": 22688.0, + "Num Detections": 18329, + "Num Negative": 18254, + "Num Positive": 75, + "Positive %": 0.4092, + "Num Positive per mm^2": 33.87 + } +} \ No newline at end of file diff --git a/317/TumorCenter_CD8_block19_x5_y9_patient317_0.json b/317/TumorCenter_CD8_block19_x5_y9_patient317_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dde427b7efd31be6a1b8ea27aa0e3b7382890d47 --- /dev/null +++ b/317/TumorCenter_CD8_block19_x5_y9_patient317_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 33732.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/317/TumorCenter_CD8_block19_x6_y9_patient317_1.json b/317/TumorCenter_CD8_block19_x6_y9_patient317_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ce99ff37c83e3b9e0ebe0672538fe3cb1c4ec790 --- /dev/null +++ b/317/TumorCenter_CD8_block19_x6_y9_patient317_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21413.7, + "Centroid Y µm": 33857.1, + "Num Detections": 18772, + "Num Negative": 18644, + "Num Positive": 128, + "Positive %": 0.6819, + "Num Positive per mm^2": 56.74 + } +} \ No newline at end of file diff --git a/317/history_text.txt b/317/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a15fdf00b661d53511c05bc1dcd0a3c90234f422 --- /dev/null +++ b/317/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: mass in the area of the right vocal fold, extending from the anterior commissure to the arytenoid cartilage. Clinical vocal fold arrest. After detailed discussion with the radiology department regarding the extent of the tumor, the decision was made to perform a partial frontolateral laryngectomy. \ No newline at end of file diff --git a/317/icd_codes.txt b/317/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/317/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/317/ops_codes.txt b/317/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7dbad1feb2ab91b1c8d33663f2e9ac067ecd10e1 --- /dev/null +++ b/317/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Hemilaryngektomie[5-301.x ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/317/patient_clinical_data.json b/317/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5b97752513c830723cb68bd50bebc9e9ed429d34 --- /dev/null +++ b/317/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin + Docetaxel", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/317/patient_pathological_data.json b/317/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c9680bc637bd85a70806c557e6e7fe6d94a7b61c --- /dev/null +++ b/317/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "317", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/317/surgery_description.txt b/317/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..82d64992c3aeff544b2dedfa4b847c4b80344804 --- /dev/null +++ b/317/surgery_description.txt @@ -0,0 +1 @@ +Hemilaryngectomy, Tracheotomy diff --git a/317/surgery_report.txt b/317/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cb7c0ff9dd6397d897081c03fa1bd670998fa184 --- /dev/null +++ b/317/surgery_report.txt @@ -0,0 +1 @@ +First consultation with the anesthesiologist. Application of local anesthesia in the median neck area. Abjode and cover the surgical area. Skin incision in the median line, running vertically. Exposure of the subcutaneous tissue, exposure of the infrahyoid musculature. Exposure of the linea alba. Dissection of the linea alba. Finding the thyroid cartilage. Finding the cricoid cartilage. Finding the ligamentum conicum. Exposure of the trachea. Exposure of the cervical trachea after transection of the isthmus of the thyroid gland and corresponding ligation. Dissection of the ligamentum conicum. Opening of the thyroid cartilage in the median line. The tumor is visible, which extends from the anterior commissure to the arytenoid cartilage and also just reaches the posterior commissure. The pouch ligament is tumor-free. The tumor extends circumscribed to the ligament, especially in the posterior parts. Careful resection of the tumor, on all sides in healthy tissue. The perichondrium of the thyroid cartilage is detached in the anterior parts. Dorsal dissection. After the arytenoid cartilage has been included in the tumor, partial resection of the arytenoid cartilage, clearly in the healthy tissue, and removal of the tumor. Only parts of the processus muscularis of the arytenoid cartilage remain. Careful hemostasis. Removal of marginal samples at all levels. All marginal samples are found to be tumor-free. An R0 resection can therefore be assumed. Grinding of the thyroid cartilage with the diamond ................... Closure of the larynx with two Vicryl sutures. Reconstruction of the ligamentum conicum. Opening of the trachea between the 2nd and 3rd tracheal ring and creation of a small tracheostoma. Careful hemostasis. Epithelialization of the tracheostoma. Wound closure in layers. Application of a pressure dressing. Completion of the procedure. Final consultation with the anesthetist. Close monitoring is absolutely essential. \ No newline at end of file diff --git a/318/InvasionFront_CD3_block17_x1_y8_patient318_0.json b/318/InvasionFront_CD3_block17_x1_y8_patient318_0.json new file mode 100644 index 0000000000000000000000000000000000000000..afa8381c482b636abbd7bc89783d3dc4cbaef654 --- /dev/null +++ b/318/InvasionFront_CD3_block17_x1_y8_patient318_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3473.2, + "Centroid Y µm": 25086.7, + "Num Detections": 13584, + "Num Negative": 12720, + "Num Positive": 864, + "Positive %": 6.36, + "Num Positive per mm^2": 447.61 + } +} \ No newline at end of file diff --git a/318/InvasionFront_CD3_block17_x2_y8_patient318_1.json b/318/InvasionFront_CD3_block17_x2_y8_patient318_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ab142a2644d55845151ad11382df9f096281137d --- /dev/null +++ b/318/InvasionFront_CD3_block17_x2_y8_patient318_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 25086.7, + "Num Detections": 16266, + "Num Negative": 15263, + "Num Positive": 1003, + "Positive %": 6.166, + "Num Positive per mm^2": 545.59 + } +} \ No newline at end of file diff --git a/318/InvasionFront_CD8_block17_x1_y8_patient318_0.json b/318/InvasionFront_CD8_block17_x1_y8_patient318_0.json new file mode 100644 index 0000000000000000000000000000000000000000..11955fe653d5b788c7971ca96d72c308acb99f2d --- /dev/null +++ b/318/InvasionFront_CD8_block17_x1_y8_patient318_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4122.8, + "Centroid Y µm": 20139.3, + "Num Detections": 10490, + "Num Negative": 10290, + "Num Positive": 200, + "Positive %": 1.907, + "Num Positive per mm^2": 142.72 + } +} \ No newline at end of file diff --git a/318/InvasionFront_CD8_block17_x2_y8_patient318_1.json b/318/InvasionFront_CD8_block17_x2_y8_patient318_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c20c5824b88f495f80a63fb4bae3890dc10a8af3 --- /dev/null +++ b/318/InvasionFront_CD8_block17_x2_y8_patient318_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 20164.3, + "Num Detections": 16895, + "Num Negative": 16734, + "Num Positive": 161, + "Positive %": 0.9529, + "Num Positive per mm^2": 88.4 + } +} \ No newline at end of file diff --git a/318/TumorCenter_CD3_block17_x1_y8_patient318_0.json b/318/TumorCenter_CD3_block17_x1_y8_patient318_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bfd30a0f01e61424c7b4f84705a4ab5e0d960d1a --- /dev/null +++ b/318/TumorCenter_CD3_block17_x1_y8_patient318_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 19714.6, + "Num Detections": 13159, + "Num Negative": 10987, + "Num Positive": 2172, + "Positive %": 16.51, + "Num Positive per mm^2": 1248.6 + } +} \ No newline at end of file diff --git a/318/TumorCenter_CD3_block17_x2_y8_patient318_1.json b/318/TumorCenter_CD3_block17_x2_y8_patient318_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b5e788b9b84a2147a06dbfd9e6c309c1a32713e8 --- /dev/null +++ b/318/TumorCenter_CD3_block17_x2_y8_patient318_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 19839.5, + "Num Detections": 12731, + "Num Negative": 12492, + "Num Positive": 239, + "Positive %": 1.877, + "Num Positive per mm^2": 128.79 + } +} \ No newline at end of file diff --git a/318/TumorCenter_CD8_block17_x1_y8_patient318_0.json b/318/TumorCenter_CD8_block17_x1_y8_patient318_0.json new file mode 100644 index 0000000000000000000000000000000000000000..406424ccb38a42d80737b3af50af9dec5be9f506 --- /dev/null +++ b/318/TumorCenter_CD8_block17_x1_y8_patient318_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6372.0, + "Centroid Y µm": 33640.1, + "Num Detections": 13223, + "Num Negative": 12291, + "Num Positive": 932, + "Positive %": 7.048, + "Num Positive per mm^2": 547.48 + } +} \ No newline at end of file diff --git a/318/TumorCenter_CD8_block17_x2_y8_patient318_1.json b/318/TumorCenter_CD8_block17_x2_y8_patient318_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2c876ded862faf809b2c5b6567c2cce0d3593989 --- /dev/null +++ b/318/TumorCenter_CD8_block17_x2_y8_patient318_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8970.3, + "Centroid Y µm": 33832.1, + "Num Detections": 12050, + "Num Negative": 11978, + "Num Positive": 72, + "Positive %": 0.5975, + "Num Positive per mm^2": 46.89 + } +} \ No newline at end of file diff --git a/318/history_text.txt b/318/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/318/icd_codes.txt b/318/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..31f58876b28caf6583e662fc242ecb509734f250 --- /dev/null +++ b/318/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 L] \ No newline at end of file diff --git a/318/ops_codes.txt b/318/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8da88d37b1f2b67ba6efa6454b8b934e1d4b0c86 --- /dev/null +++ b/318/ops_codes.txt @@ -0,0 +1 @@ +Laserresektion Larynxgewebe mit Stützlaryngoskopie[5-302.5 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/318/patient_clinical_data.json b/318/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b4cee1432cc3b7c609e3ce90d509d6decdcac140 --- /dev/null +++ b/318/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/318/patient_pathological_data.json b/318/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7a022dfb78f6bfc86417c5ac9dd49d93df3581d2 --- /dev/null +++ b/318/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "318", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/318/surgery_description.txt b/318/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b45ea1174e5848dbc7e53358c76517376cec36f6 --- /dev/null +++ b/318/surgery_description.txt @@ -0,0 +1 @@ +Laser resection diff --git a/318/surgery_report.txt b/318/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4209b977791a0af5ed5ba983f4af1bd0c9417cb7 --- /dev/null +++ b/318/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesiologist. Adjustment of the larynx with the size C small bore tube. Laborious exposure of the anterior commissure. Incision of the lesion in healthy tissue with resection of the vocal cord and parts of the vocalis muscle. As far as can be assessed intraoperatively, resection is successful in all planes in healthy tissue. Careful hemostasis. Removal of two marginal samples. Careful hemostasis. Dry conditions at the end of the operation. Completion of the procedure without complications. Final consultation with the anesthesiologist. Note: The resection was performed with the CO2 laser and with the aid of a microscope. Close follow-up examinations are absolutely necessary. Exposure of the anterior commissure could only be achieved by applying external pressure. However, the anterior commissure was clearly adjustable. \ No newline at end of file diff --git a/319/InvasionFront_CD3_block15_x5_y11_patient319_0.json b/319/InvasionFront_CD3_block15_x5_y11_patient319_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dfc52e9637611ddb701f12d086572eed38553bb9 --- /dev/null +++ b/319/InvasionFront_CD3_block15_x5_y11_patient319_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 37205.3, + "Num Detections": 24840, + "Num Negative": 22867, + "Num Positive": 1973, + "Positive %": 7.943, + "Num Positive per mm^2": 751.21 + } +} \ No newline at end of file diff --git a/319/InvasionFront_CD3_block15_x6_y11_patient319_1.json b/319/InvasionFront_CD3_block15_x6_y11_patient319_1.json new file mode 100644 index 0000000000000000000000000000000000000000..99fcb58b8affc848fd75d23f46e7a4da692dc2c6 --- /dev/null +++ b/319/InvasionFront_CD3_block15_x6_y11_patient319_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21588.6, + "Centroid Y µm": 37180.3, + "Num Detections": 23920, + "Num Negative": 22578, + "Num Positive": 1342, + "Positive %": 5.61, + "Num Positive per mm^2": 532.82 + } +} \ No newline at end of file diff --git a/319/InvasionFront_CD8_block15_x5_y11_patient319_0.json b/319/InvasionFront_CD8_block15_x5_y11_patient319_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4886b84767dbb5bb6b64caa09c8e30b89f81ba79 --- /dev/null +++ b/319/InvasionFront_CD8_block15_x5_y11_patient319_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16597.6, + "Centroid Y µm": 26739.7, + "Num Detections": 16688, + "Num Negative": 15263, + "Num Positive": 1425, + "Positive %": 8.539, + "Num Positive per mm^2": 665.4 + } +} \ No newline at end of file diff --git a/319/InvasionFront_CD8_block15_x6_y11_patient319_1.json b/319/InvasionFront_CD8_block15_x6_y11_patient319_1.json new file mode 100644 index 0000000000000000000000000000000000000000..43efd4a3f783c2b0a36ba24a3cb23f8ce1c18e15 --- /dev/null +++ b/319/InvasionFront_CD8_block15_x6_y11_patient319_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19141.1, + "Centroid Y µm": 26662.1, + "Num Detections": 13528, + "Num Negative": 12417, + "Num Positive": 1111, + "Positive %": 8.213, + "Num Positive per mm^2": 627.16 + } +} \ No newline at end of file diff --git a/319/TumorCenter_CD3_block15_x5_y11_patient319_0.json b/319/TumorCenter_CD3_block15_x5_y11_patient319_0.json new file mode 100644 index 0000000000000000000000000000000000000000..92af2746c4fc4de2dc82dbfdd1abf6fa66acd848 --- /dev/null +++ b/319/TumorCenter_CD3_block15_x5_y11_patient319_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 31033.6, + "Num Detections": 23054, + "Num Negative": 21399, + "Num Positive": 1655, + "Positive %": 7.179, + "Num Positive per mm^2": 626.99 + } +} \ No newline at end of file diff --git a/319/TumorCenter_CD3_block15_x6_y11_patient319_1.json b/319/TumorCenter_CD3_block15_x6_y11_patient319_1.json new file mode 100644 index 0000000000000000000000000000000000000000..83faf641612a4ce365395baf0f58035f35f7dd38 --- /dev/null +++ b/319/TumorCenter_CD3_block15_x6_y11_patient319_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 31108.5, + "Num Detections": 24591, + "Num Negative": 23462, + "Num Positive": 1129, + "Positive %": 4.591, + "Num Positive per mm^2": 415.43 + } +} \ No newline at end of file diff --git a/319/TumorCenter_CD8_block15_x5_y11_patient319_0.json b/319/TumorCenter_CD8_block15_x5_y11_patient319_0.json new file mode 100644 index 0000000000000000000000000000000000000000..26152173d1b97f3b9e7d9e68527d4d076c44f77a --- /dev/null +++ b/319/TumorCenter_CD8_block15_x5_y11_patient319_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 27435.5, + "Num Detections": 23914, + "Num Negative": 21769, + "Num Positive": 2145, + "Positive %": 8.97, + "Num Positive per mm^2": 805.9 + } +} \ No newline at end of file diff --git a/319/TumorCenter_CD8_block15_x6_y11_patient319_1.json b/319/TumorCenter_CD8_block15_x6_y11_patient319_1.json new file mode 100644 index 0000000000000000000000000000000000000000..46d4fecb4186e48c51e356c507950226beb90ac6 --- /dev/null +++ b/319/TumorCenter_CD8_block15_x6_y11_patient319_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21188.8, + "Centroid Y µm": 27485.4, + "Num Detections": 25850, + "Num Negative": 23578, + "Num Positive": 2272, + "Positive %": 8.789, + "Num Positive per mm^2": 834.8 + } +} \ No newline at end of file diff --git a/319/history_text.txt b/319/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ca4e509749e39845c63a2130b7f9de11ad86dc2d --- /dev/null +++ b/319/history_text.txt @@ -0,0 +1 @@ +During a panendoscopy <2014>, a cT2 cN2b tongue margin carcinoma on the right was confirmed histologically in the patient. After external pre-diagnosis in our interdisciplinary tumor conference, the primary surgical procedure was recommended. \ No newline at end of file diff --git a/319/icd_codes.txt b/319/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b726963807f048843213f2656edbce103649d7e --- /dev/null +++ b/319/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zunge, nicht näher bezeichnet[C02.9 ] \ No newline at end of file diff --git a/319/ops_codes.txt b/319/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..61c6785ea206c1c3fee3e223e69ed15d5717ab96 --- /dev/null +++ b/319/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 R] Selektive Neck dissection in 4 Regionen[5-403.03 L] \ No newline at end of file diff --git a/319/patient_clinical_data.json b/319/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..402f13dbf863ebd84f444d3196bf811319a9d33e --- /dev/null +++ b/319/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 73, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/319/patient_pathological_data.json b/319/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bb914bcc82399e77fa732edf4f2ee14f236649d0 --- /dev/null +++ b/319/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "319", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/319/surgery_description.txt b/319/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1b3ff6659f50ed31123b8298b1ade7fcb5db9b3 --- /dev/null +++ b/319/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Neck dissection diff --git a/319/surgery_report.txt b/319/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..af0d187f5bad228b2f230fa823eb932bec4132ac --- /dev/null +++ b/319/surgery_report.txt @@ -0,0 +1 @@ +First inspection of the primary tumor region. This revealed a partially ulcerated process of the right edge of the tongue, measuring approx. 2 x 4 cm in total with infiltration of a good 1-1.5 cm in depth; the lateral and posterior floor of the mouth was largely free and regular. There is also no infiltration of the glossotonsillar groove. Good exposure possibility. The tongue is now snared transorally. Incision of the tumor with a safety margin of a good 1 cm, also in the depth of a soft tissue mantle of 1 cm on all sides. Ligation of an arterial and a venous side branch and removal of the tumor macroscopically on all sides in sano, which is thread-marked on all sides for frozen section diagnostics. Here, all margins including the basal margin are diagnosed as tumor- and dysplasia-free, hence a clear R0 situation. Later, after final inspection and wound irrigation, the adapting mucosa is used to compress the wound surface. The lateral floor of the mouth is easily displaceable and there is no penetrating defect, so there is no indication for reconstruction here. Turn to the right side first for neck dissection. Skin incision made at the anterior edge of the sternocleidomastoid muscle, cutting through skin and subcutaneous tissue. Dissection of the platysma, exposure and preservation of the external jugular vein and the auricular nerve. Exposure of the sternocleidomastoid muscle and omohyoid muscle, submandibular gland and digastric muscle. Removal of the anterior neck preparation with careful protection of the facial vein, the superior thyroid artery, the hypoglossal nerve and the cervical nerve. Exposure of the accessorius nerve. Clearing of the accessorius triangle, free preparation of the internal jugular vein with exposure of the external and internal carotid artery, which shows a clear kinking with a lateral course. Exposure of the vagus nerve, clearing of level V with careful protection of the cervical plexus branches. Finally, evacuation of level Ib. Dislocation of the submandibular gland, evacuation of the level with careful protection of the ramus marginalis mandibulae. Final wound inspection and wound irrigation and, if the wound is dry, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Turn to the opposite side. In principle, the same procedure is used here. After exposing and preserving the external jugular vein and auricular nerve, expose the limited musculature. Then remove the anterior neck preparation and preserve the V. facialis, A. thyroidea superior, N. hypoglossus. Exposure of the accessorius nerve, here the vascular tissue is left in place and level IIb is therefore only partially cleared out. Careful dissection of the internal jugular vein. Exposure of the vagus nerve and the course of the internal carotid artery exactly as described on the opposite side. Clear kinking here too. Deposition of the specimen at the transition to level Va with careful protection of the cervical plexus branches. Here too, final wound irrigation and, if the wound is dry, insertion of a 10-gauge Redon drainage and careful two-layer wound closure. Subsequently, as described above, final enoral inspection and, after treatment of the defect, completion of the procedure without any indication of complications. The patient received intraoperative single shot antibiotics with Unacid 3 g. Conclusion: Intraoperative R0 resected cT2 cN2b tongue margin carcinoma on the right. After receiving the definitive histology, presentation at our interdisciplinary tumor conference to determine the adjuvant procedure. \ No newline at end of file diff --git a/320/InvasionFront_CD3_block13_x5_y12_patient320_0.json b/320/InvasionFront_CD3_block13_x5_y12_patient320_0.json new file mode 100644 index 0000000000000000000000000000000000000000..de4180d3d946733f40bd59d5b9440dcdb3fb3594 --- /dev/null +++ b/320/InvasionFront_CD3_block13_x5_y12_patient320_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 28909.7, + "Num Detections": 17421, + "Num Negative": 15742, + "Num Positive": 1679, + "Positive %": 9.638, + "Num Positive per mm^2": 799.88 + } +} \ No newline at end of file diff --git a/320/InvasionFront_CD3_block13_x6_y12_patient320_1.json b/320/InvasionFront_CD3_block13_x6_y12_patient320_1.json new file mode 100644 index 0000000000000000000000000000000000000000..12027a508a6598bae6a2d46fb9f6c61f2ba5162c --- /dev/null +++ b/320/InvasionFront_CD3_block13_x6_y12_patient320_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 28884.7, + "Num Detections": 19410, + "Num Negative": 17557, + "Num Positive": 1853, + "Positive %": 9.547, + "Num Positive per mm^2": 854.02 + } +} \ No newline at end of file diff --git a/320/InvasionFront_CD8_block13_x5_y12_patient320_0.json b/320/InvasionFront_CD8_block13_x5_y12_patient320_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a1470553207a47e56a8f0b2c05324d302db82d4b --- /dev/null +++ b/320/InvasionFront_CD8_block13_x5_y12_patient320_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 31183.5, + "Num Detections": 19880, + "Num Negative": 18366, + "Num Positive": 1514, + "Positive %": 7.616, + "Num Positive per mm^2": 682.17 + } +} \ No newline at end of file diff --git a/320/InvasionFront_CD8_block13_x6_y12_patient320_1.json b/320/InvasionFront_CD8_block13_x6_y12_patient320_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4fa95cc2b6d3af4ff5c7d23dec1d55a66736a9a2 --- /dev/null +++ b/320/InvasionFront_CD8_block13_x6_y12_patient320_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 31408.4, + "Num Detections": 19166, + "Num Negative": 17742, + "Num Positive": 1424, + "Positive %": 7.43, + "Num Positive per mm^2": 636.79 + } +} \ No newline at end of file diff --git a/320/TumorCenter_CD3_block13_x5_y12_patient320_0.json b/320/TumorCenter_CD3_block13_x5_y12_patient320_0.json new file mode 100644 index 0000000000000000000000000000000000000000..060a4ad8350f4bcd7db82a9a0f287d478233f433 --- /dev/null +++ b/320/TumorCenter_CD3_block13_x5_y12_patient320_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15816.6, + "Centroid Y µm": 36680.6, + "Num Detections": 17395, + "Num Negative": 16101, + "Num Positive": 1294, + "Positive %": 7.439, + "Num Positive per mm^2": 592.46 + } +} \ No newline at end of file diff --git a/320/TumorCenter_CD3_block13_x6_y12_patient320_1.json b/320/TumorCenter_CD3_block13_x6_y12_patient320_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a5223cc4c8b03a546212cdbb5557f345cac8369 --- /dev/null +++ b/320/TumorCenter_CD3_block13_x6_y12_patient320_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18240.3, + "Centroid Y µm": 36905.5, + "Num Detections": 17648, + "Num Negative": 15944, + "Num Positive": 1704, + "Positive %": 9.655, + "Num Positive per mm^2": 806.81 + } +} \ No newline at end of file diff --git a/320/TumorCenter_CD8_block13_x5_y12_patient320_0.json b/320/TumorCenter_CD8_block13_x5_y12_patient320_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3be9429cb080520edb9f3781b173b5e372a30190 --- /dev/null +++ b/320/TumorCenter_CD8_block13_x5_y12_patient320_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18640.1, + "Centroid Y µm": 28884.7, + "Num Detections": 20201, + "Num Negative": 19432, + "Num Positive": 769, + "Positive %": 3.807, + "Num Positive per mm^2": 348.11 + } +} \ No newline at end of file diff --git a/320/TumorCenter_CD8_block13_x6_y12_patient320_1.json b/320/TumorCenter_CD8_block13_x6_y12_patient320_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3260f76f79de28bac3cc88925e1df3e4d169f7c8 --- /dev/null +++ b/320/TumorCenter_CD8_block13_x6_y12_patient320_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21113.8, + "Centroid Y µm": 28609.9, + "Num Detections": 18573, + "Num Negative": 17825, + "Num Positive": 748, + "Positive %": 4.027, + "Num Positive per mm^2": 366.78 + } +} \ No newline at end of file diff --git a/320/history_text.txt b/320/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/320/icd_codes.txt b/320/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..690584981b660e601dfb869b1c4b276e542a07ed --- /dev/null +++ b/320/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zunge, mehrere Teilbereiche überlappend[C02.8 ] \ No newline at end of file diff --git a/320/ops_codes.txt b/320/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3752454e53064441b44f7a4524a45ed118cea8dd --- /dev/null +++ b/320/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Permanente Tracheostomaanlage[5-312.0 ] Resektion Ohrmuschel partiell[5-182.0 R] \ No newline at end of file diff --git a/320/patient_clinical_data.json b/320/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2d928f1f81fbdc7eb824703dde9768270df452bd --- /dev/null +++ b/320/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 77, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/320/patient_pathological_data.json b/320/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..df63e84ebe3a60b5ad8a549e94816ac642ac891b --- /dev/null +++ b/320/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "320", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/320/surgery_description.txt b/320/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0a5ad194dea3d58290f43a7e3f8b9b482f5a5f23 --- /dev/null +++ b/320/surgery_description.txt @@ -0,0 +1 @@ +Transoral partial glossectomy, Tracheostomy creation diff --git a/320/surgery_report.txt b/320/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e7387880499e440f6723b84c1028e43850c62c7a --- /dev/null +++ b/320/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, transoral tumor resection is performed first. The tongue is disluxed after setting the mouth retractors. Now look at the ulcer measuring approx. 2 x 2 cm on the left edge of the tongue, approximately in the middle. The tumor is then resected macroscopically 1 1/2-2 cm from the resection margin on all sides. The healthy musculature is viewed macroscopically. Suture marking of the specimen, which is sent in for frozen section histology diagnostics. Tumor infiltrates can still be seen in the ventral margin and in depth to the internal musculature as well as lymphangiosis towards the floor of the mouth in a lateral direction. Corresponding resections are then carried out at the corresponding sites, followed by renewed marginal samples further laterally. All of the marginal samples proved to be tumor-free. In the resection of the tumor base, isolated disseminated tumor nests are found in healthy muscles. However, the defect now covers the entire left tongue up to just before the base of the tongue, so that further resection is not possible. The remaining right tongue body is then adapted again in several layers with mattress sutures and sutured to the left resection margin. In the meantime, after disinfecting the skin, a sample is taken from the mass in the right envelope fold. After skin incision, the mass is dissected under the skin and removed. A frozen section histology also reveals a carcinoma corresponding to that in the tongue. Histologically for the time being. Careful hemostasis by bipolar coagulation. Two-layer wound closure. Sterile dressing. Subsequent transition to tracheostomy. The patient cannot be intubated either conventionally or with the GlideScope. Only flexible bronchoscopy. In addition, postoperative dysphagia with aspiration is to be expected due to the extensive tongue resection. A tracheostoma is therefore created. After skin incision, preparation of the linea alba. The muscles are pushed apart. Pass under the isthmus and place in the midline. Thus exposing the first 4 tracheal clasps. Opening of the trachea between the 2nd and 3rd tracheal clasps. Completion of the mucocutaneous anastomosis. Removal of the tube and problem-free intubation of the patient onto a 9-gauge cannula. End of the operation, handover of the patient to anesthesia. \ No newline at end of file diff --git a/321/InvasionFront_CD3_block12_x1_y8_patient321_0.json b/321/InvasionFront_CD3_block12_x1_y8_patient321_0.json new file mode 100644 index 0000000000000000000000000000000000000000..31273cf470afc56701a48c56a217ddeb17183de6 --- /dev/null +++ b/321/InvasionFront_CD3_block12_x1_y8_patient321_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 24237.2, + "Num Detections": 21777, + "Num Negative": 19212, + "Num Positive": 2565, + "Positive %": 11.78, + "Num Positive per mm^2": 1073.1 + } +} \ No newline at end of file diff --git a/321/InvasionFront_CD3_block12_x2_y8_patient321_1.json b/321/InvasionFront_CD3_block12_x2_y8_patient321_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0e6062fcae2c47e5bef45f77b331999d435624a2 --- /dev/null +++ b/321/InvasionFront_CD3_block12_x2_y8_patient321_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 24312.1, + "Num Detections": 20323, + "Num Negative": 18663, + "Num Positive": 1660, + "Positive %": 8.168, + "Num Positive per mm^2": 765.63 + } +} \ No newline at end of file diff --git a/321/InvasionFront_CD8_block12_x1_y8_patient321_0.json b/321/InvasionFront_CD8_block12_x1_y8_patient321_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8af786c3acd47a0e37fa6a2f9d8e17b0d6321618 --- /dev/null +++ b/321/InvasionFront_CD8_block12_x1_y8_patient321_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4997.4, + "Centroid Y µm": 24362.1, + "Num Detections": 21594, + "Num Negative": 17506, + "Num Positive": 4088, + "Positive %": 18.93, + "Num Positive per mm^2": 1691.8 + } +} \ No newline at end of file diff --git a/321/InvasionFront_CD8_block12_x2_y8_patient321_1.json b/321/InvasionFront_CD8_block12_x2_y8_patient321_1.json new file mode 100644 index 0000000000000000000000000000000000000000..86f7512b1fbba5656fbc37796feeb3784fe010c6 --- /dev/null +++ b/321/InvasionFront_CD8_block12_x2_y8_patient321_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7371.1, + "Centroid Y µm": 23987.3, + "Num Detections": 19423, + "Num Negative": 17223, + "Num Positive": 2200, + "Positive %": 11.33, + "Num Positive per mm^2": 1047.8 + } +} \ No newline at end of file diff --git a/321/TumorCenter_CD3_block12_x1_y8_patient321_0.json b/321/TumorCenter_CD3_block12_x1_y8_patient321_0.json new file mode 100644 index 0000000000000000000000000000000000000000..73ed66f264522c1d1323ca0ed2c6f82ec60c0da4 --- /dev/null +++ b/321/TumorCenter_CD3_block12_x1_y8_patient321_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3348.2, + "Centroid Y µm": 19789.5, + "Num Detections": 25142, + "Num Negative": 17328, + "Num Positive": 7814, + "Positive %": 31.08, + "Num Positive per mm^2": 3121.2 + } +} \ No newline at end of file diff --git a/321/TumorCenter_CD3_block12_x2_y8_patient321_1.json b/321/TumorCenter_CD3_block12_x2_y8_patient321_1.json new file mode 100644 index 0000000000000000000000000000000000000000..94fcb29413ee8786bff00627173765b9a376ed80 --- /dev/null +++ b/321/TumorCenter_CD3_block12_x2_y8_patient321_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 19839.5, + "Num Detections": 21805, + "Num Negative": 15220, + "Num Positive": 6585, + "Positive %": 30.2, + "Num Positive per mm^2": 2735.1 + } +} \ No newline at end of file diff --git a/321/TumorCenter_CD8_block12_x1_y8_patient321_0.json b/321/TumorCenter_CD8_block12_x1_y8_patient321_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fb9be8e02de952cf1b6f8747ddfba7d15a66be60 --- /dev/null +++ b/321/TumorCenter_CD8_block12_x1_y8_patient321_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 28784.8, + "Num Detections": 24480, + "Num Negative": 18241, + "Num Positive": 6239, + "Positive %": 25.49, + "Num Positive per mm^2": 2520.2 + } +} \ No newline at end of file diff --git a/321/TumorCenter_CD8_block12_x2_y8_patient321_1.json b/321/TumorCenter_CD8_block12_x2_y8_patient321_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ea5f1756a47c339b53de1587086bc26680ac5d48 --- /dev/null +++ b/321/TumorCenter_CD8_block12_x2_y8_patient321_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9020.2, + "Centroid Y µm": 28909.7, + "Num Detections": 23170, + "Num Negative": 18221, + "Num Positive": 4949, + "Positive %": 21.36, + "Num Positive per mm^2": 2059.3 + } +} \ No newline at end of file diff --git a/321/history_text.txt b/321/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/321/icd_codes.txt b/321/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..03b7ca905f8d56862430bc30a8f15f0370ddbd2b --- /dev/null +++ b/321/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/321/ops_codes.txt b/321/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9130ab8ad89778e25cdb386bd5144cbc0f80e0fe --- /dev/null +++ b/321/ops_codes.txt @@ -0,0 +1 @@ +Exzision und Destruktion von erkranktem Gewebe des Pharynx: Resektion, radikal: Sonstige[5-292.2x ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Destruktion: Sonstige[5-292.3x ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 4 Regionen[5-403.20 B] Plastische Rekonstruktion mit lokalen Lappen an Muskeln und Faszien: Fasziokutaner Lappen, gefäßgestielt: Kopf und Hals[5-857.10 R] Unterarm[5-858.03 R] Permanente Tracheostomie: Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Bronchoskopie und Tracheoskopie durch Inzision und intraoperativ: Tracheoskopie[1-690.1 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] \ No newline at end of file diff --git a/321/patient_clinical_data.json b/321/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..11590d5e34422a21bd79443dacd475220a696acc --- /dev/null +++ b/321/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/321/patient_pathological_data.json b/321/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3d0b352f79fd8c16d7c8e6e81e7fce1b94cb5dea --- /dev/null +++ b/321/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "321", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/321/surgery_description.txt b/321/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..503c5c32a983fdc61e3f8ea9f4c4e517d1c2c6b4 --- /dev/null +++ b/321/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection of right tonsil, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheotomy, PEG placement, Panendoscopy diff --git a/321/surgery_report.txt b/321/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b7a7a5227cf7ce31400a6cbaa1761333b5cc9e40 --- /dev/null +++ b/321/surgery_report.txt @@ -0,0 +1 @@ +At the beginning of the operation, the surgeon positions the patient. Subsequent entry with rigid endoscopy. Inspection of the subglottic slope and trachea. Unobtrusive conditions. Now nasal intubation. Subsequent inspection of the oropharynx, hypopharynx and larynx, also under the microscope. The previously described tumor of the right tonsil is seen, which ends at the lower tonsil pole, but extends palpatorily, as already recognized on CT, far to the submucosal cranial side and infiltrates here into the palate on the right side, but does not cross the midline here. Subsequent flexible esophagoscopy. Unobtrusive conditions as far as the stomach. After performing the diaphanoscopy and insertion of the troicart, the PEG is inserted in the typical manner using the thread pull-through method. The tumor is then positioned with the tonsil retractor and cut around with the electric needle. Dissection from cranial to caudal, cutting around the tumor with a large safety margin. Laterally, the tumor does not appear to be growing beyond the capsule of the tonsil, so that the tumor can be removed in toto from the pharyngeal wall with the raspatory without difficulty. Removal of the tumor caudally. Subsequent formation of a resectate in the cranial part, which is also sent for final histology. Finally, the edge samples are taken. These are found to be tumor-free. Now turn to the neck dissection on the left side: To do this, make a skin incision in the typical manner along the anterior edge of the sternocleidomastoid. Expose the same. Dissection of the neck sheath. Exposure of the accessory nerve, vagus nerve and hypoglossal nerve. Dissection of the lateral neck preparation from the digaster to the omohyoid, sparing the above-mentioned structures and the main plexus branches. Careful hemostasis. Evacuation of the medial neck preparation, taking the capsule of the submandibular gland with it and again careful hemostasis, H2O2 irrigation and insertion of a Redon drain. Finally, two-layer wound closure. Now neck dissection on the right side: identical procedure here. Also dissection from the digaster to the omohyoid. Expose the cervical vascular sheath, the vagus nerve, the accessorius nerve and the hypoglossal nerve. Clearing out the lateral neck preparation while protecting the structures and the plexus branches. Careful hemostasis. Dissection along the capsule of the submandibular gland in a medial direction and removal of the medial neck preparation. Subsequent careful hemostasis. H2O2 irrigation. Finally, this wound is left open and the vascular trunk of the superior thyroid is explored. This can be seen at the level of the bulb, leaving the externa and sufficiently wide and pulsating well; the internal jugular vein is also visualized. Insertion of H2O2 swabs and turning to the tracheotomy: For this purpose, skin incision with dissection through the subcutis and pushing apart the prelaryngeal muscles. Undermining of the thyroid gland. Insertion of clamps. Cutting of the same in the midline. Subsequent repositioning. After locating the anterior wall of the trachea, the incision is made between the 2nd and 3rd tracheal cartilage. Form a Björk flap in the typical manner and skin adaptation to the trachea to form an epithelialized stoma. Now reintubation with an 8-gauge Rügheimer cannula. Then lift the radial flap. To do this, cut around the skin preparation. Remove the fascia from the musculature. Locate the radial artery. Then follow it into the crook of the elbow and release it from its bed. The radial artery is deposited in the antecubital fossa before the interosseous artery leaves. The accompanying veins are placed in a confluence. Careful hemostasis is then performed. Heparin irrigation. Attachment of the perfusor. Due to ABC intolerance, full heparinization is performed here. Now lift the split skin from the groin. This defect is sutured primarily after careful hemostasis and insertion of a Redon drainage. Split skin coverage of the forearm. The skin is then sutured down to the crook of the elbow. Application of a forearm splint. Fitting of the skin preparation into the defect. Reconstruct the palatal arch and, after undermining, pull the flap pedicle through towards the neck. Anastomize the radial artery with the superior thyroid artery microscopically. Then end-to-end, then end-to-side anastomosis of the accompanying veins in their confluence with the jugular artery. After careful hemostasis and checking for good flow, H2O2 irrigation is performed again and the wound is closed in two layers. Check the wound again at the end of the procedure. No evidence of bleeding. Flap vital. \ No newline at end of file diff --git a/322/InvasionFront_CD3_block3_x3_y8_patient322_0.json b/322/InvasionFront_CD3_block3_x3_y8_patient322_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cb39c027eda43f0c0604cce1853ce0f7be6b19ae --- /dev/null +++ b/322/InvasionFront_CD3_block3_x3_y8_patient322_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12146.6, + "Centroid Y µm": 25618.7, + "Num Detections": 5204, + "Num Negative": 5189, + "Num Positive": 15, + "Positive %": 0.2882, + "Num Positive per mm^2": 24.61 + } +} \ No newline at end of file diff --git a/322/InvasionFront_CD3_block3_x4_y8_patient322_1.json b/322/InvasionFront_CD3_block3_x4_y8_patient322_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4b95543070dfcd85a6c622b41fb544065e474dd9 --- /dev/null +++ b/322/InvasionFront_CD3_block3_x4_y8_patient322_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14833.2, + "Centroid Y µm": 26070.8, + "Num Detections": 15300, + "Num Negative": 15163, + "Num Positive": 137, + "Positive %": 0.8954, + "Num Positive per mm^2": 81.96 + } +} \ No newline at end of file diff --git a/322/InvasionFront_CD8_block3_x3_y7_patient322_0.json b/322/InvasionFront_CD8_block3_x3_y7_patient322_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c1d122a926e18bf4a2a4a027058cc1a853630eda --- /dev/null +++ b/322/InvasionFront_CD8_block3_x3_y7_patient322_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12493.4, + "Centroid Y µm": 17140.9, + "Num Detections": 9789, + "Num Negative": 5975, + "Num Positive": 3814, + "Positive %": 38.96, + "Num Positive per mm^2": 3554.6 + } +} \ No newline at end of file diff --git a/322/InvasionFront_CD8_block3_x4_y7_patient322_1.json b/322/InvasionFront_CD8_block3_x4_y7_patient322_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8fdb3310d1d24c3f7900c021196a72296d9aae6e --- /dev/null +++ b/322/InvasionFront_CD8_block3_x4_y7_patient322_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15004.2, + "Centroid Y µm": 17261.0, + "Num Detections": 23038, + "Num Negative": 20099, + "Num Positive": 2939, + "Positive %": 12.76, + "Num Positive per mm^2": 1249.2 + } +} \ No newline at end of file diff --git a/322/TumorCenter_CD3_block3_x3_y7_patient322_0.json b/322/TumorCenter_CD3_block3_x3_y7_patient322_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cd8e6751bdebd91dde6d63c9d117c4826a70395c --- /dev/null +++ b/322/TumorCenter_CD3_block3_x3_y7_patient322_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10869.2, + "Centroid Y µm": 23787.4, + "Num Detections": 22335, + "Num Negative": 19231, + "Num Positive": 3104, + "Positive %": 13.9, + "Num Positive per mm^2": 1234.1 + } +} \ No newline at end of file diff --git a/322/TumorCenter_CD3_block3_x4_y7_patient322_1.json b/322/TumorCenter_CD3_block3_x4_y7_patient322_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f1440b51aee854bba173500f4896e2ac067d220 --- /dev/null +++ b/322/TumorCenter_CD3_block3_x4_y7_patient322_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13396.5, + "Centroid Y µm": 23803.9, + "Num Detections": 25490, + "Num Negative": 20771, + "Num Positive": 4719, + "Positive %": 18.51, + "Num Positive per mm^2": 1747.6 + } +} \ No newline at end of file diff --git a/322/TumorCenter_CD8_block3_x3_y7_patient322_0.json b/322/TumorCenter_CD8_block3_x3_y7_patient322_0.json new file mode 100644 index 0000000000000000000000000000000000000000..98a425d559a812dcca08ce6440034aaa1b490776 --- /dev/null +++ b/322/TumorCenter_CD8_block3_x3_y7_patient322_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11668.8, + "Centroid Y µm": 18765.1, + "Num Detections": 21959, + "Num Negative": 19055, + "Num Positive": 2904, + "Positive %": 13.22, + "Num Positive per mm^2": 1146.2 + } +} \ No newline at end of file diff --git a/322/TumorCenter_CD8_block3_x4_y7_patient322_1.json b/322/TumorCenter_CD8_block3_x4_y7_patient322_1.json new file mode 100644 index 0000000000000000000000000000000000000000..990350f0da8441827b99a305139a175c6c1da7df --- /dev/null +++ b/322/TumorCenter_CD8_block3_x4_y7_patient322_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14192.5, + "Centroid Y µm": 18840.0, + "Num Detections": 23785, + "Num Negative": 18151, + "Num Positive": 5634, + "Positive %": 23.69, + "Num Positive per mm^2": 2155.3 + } +} \ No newline at end of file diff --git a/322/history_text.txt b/322/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/322/icd_codes.txt b/322/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..806ff29aad9657c4d0c61c32db00221ac85389c6 --- /dev/null +++ b/322/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Fossa tonsillaris[C09.0 R] \ No newline at end of file diff --git a/322/ops_codes.txt b/322/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..70f6a6c0340db78059d5c7f70e203e51dfbdd545 --- /dev/null +++ b/322/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Anwendung eines komplexen OP-Roboters (Zusatzkode)[5-987.0 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion][5-295.xx ] Inzision Zungengrund[5-250.x ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/322/patient_clinical_data.json b/322/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6da593ebd892cc4c4a4e1c6d849abb46109715f7 --- /dev/null +++ b/322/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 68, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 4, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/322/patient_pathological_data.json b/322/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..00728167f6735d65aa995b73e84ebc7da5056d55 --- /dev/null +++ b/322/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "322", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 17, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/322/surgery_description.txt b/322/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..206fe857e63df7ce164404684a5f7868c6fcfa30 --- /dev/null +++ b/322/surgery_description.txt @@ -0,0 +1 @@ +Robot-assisted tumor tonsillectomy, Tracheotomy diff --git a/322/surgery_report.txt b/322/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9bd5b9b752bcaa145b4345abd87bd6de9c672f24 --- /dev/null +++ b/322/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by anesthesia colleagues. Setting up the surgical robot. Insertion of the mouth blocker by and exposure of the tumor. The tumor is located in the right tonsillar lobe and extends to the anterior and posterior palatal arch as well as partially to the base of the tongue. Now start with resection at the cranial edge and continue the resection, taking parts of the anterior and posterior palatal arch and parts of the base of the tongue with it. Laterally, a very deep dissection must be made so that neck fat is visible after the resection and clear pulsation from the carotid artery is also visible. Marginal samples are taken from the specimen itself and cranially also from the situs. All edge samples are tumor-free in the frozen section. Overall macroscopic safety margin of at least 0.5 cm, therefore the possibility of inclusion in the direct study. Neck dissection must be performed in two stages after granulation of the defect in the oropharyngeal region. Another tracheotomy is performed by . Injection for this. Skin incision in the usual manner. Then dissection in depth. Exposure of the musculature. Splitting of the musculature in the midline. Exposure of the anterior wall of the trachea. This is relatively successful as the patient had previously undergone a thyroidectomy. Entering the trachea between the 2nd and 3rd tracheal cartilage. Creation of a visor tracheotomy. Creation of a mucocutaneous anastomosis. Re-intubation to an 8-gauge tracheostomy tube and completion of the procedure without complications. Please present the patient at the tumor conference after the neck dissection on both sides. \ No newline at end of file diff --git a/323/InvasionFront_CD3_block16_x1_y1_patient323_0.json b/323/InvasionFront_CD3_block16_x1_y1_patient323_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be9f72ba7dc72ff2e9382912de5d7c899102f1a7 --- /dev/null +++ b/323/InvasionFront_CD3_block16_x1_y1_patient323_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4478.2, + "Centroid Y µm": 6976.9, + "Num Detections": 14299, + "Num Negative": 14169, + "Num Positive": 130, + "Positive %": 0.9092, + "Num Positive per mm^2": 62.93 + } +} \ No newline at end of file diff --git a/323/InvasionFront_CD3_block16_x2_y1_patient323_1.json b/323/InvasionFront_CD3_block16_x2_y1_patient323_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d635dfbbb867bed5ca599f740b1769d9fe9b526f --- /dev/null +++ b/323/InvasionFront_CD3_block16_x2_y1_patient323_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7216.8, + "Centroid Y µm": 7040.3, + "Num Detections": 11260, + "Num Negative": 10121, + "Num Positive": 1139, + "Positive %": 10.12, + "Num Positive per mm^2": 798.03 + } +} \ No newline at end of file diff --git a/323/InvasionFront_CD8_block16_x1_y1_patient323_0.json b/323/InvasionFront_CD8_block16_x1_y1_patient323_0.json new file mode 100644 index 0000000000000000000000000000000000000000..29315918bc05acb187d8615c7ad5f65227ccf6ef --- /dev/null +++ b/323/InvasionFront_CD8_block16_x1_y1_patient323_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3959.0, + "Centroid Y µm": 2433.2, + "Num Detections": 16835, + "Num Negative": 16583, + "Num Positive": 252, + "Positive %": 1.497, + "Num Positive per mm^2": 127.69 + } +} \ No newline at end of file diff --git a/323/InvasionFront_CD8_block16_x2_y1_patient323_1.json b/323/InvasionFront_CD8_block16_x2_y1_patient323_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a4606dbfe9110f6cd2271fe6186e419bf815b708 --- /dev/null +++ b/323/InvasionFront_CD8_block16_x2_y1_patient323_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6458.0, + "Centroid Y µm": 2729.9, + "Num Detections": 12176, + "Num Negative": 11342, + "Num Positive": 834, + "Positive %": 6.85, + "Num Positive per mm^2": 582.42 + } +} \ No newline at end of file diff --git a/323/TumorCenter_CD3_block16_x1_y1_patient323_0.json b/323/TumorCenter_CD3_block16_x1_y1_patient323_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ca8fef73b33c11d27eded5a992433c555a63557 --- /dev/null +++ b/323/TumorCenter_CD3_block16_x1_y1_patient323_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5247.2, + "Centroid Y µm": 2298.8, + "Num Detections": 21881, + "Num Negative": 19595, + "Num Positive": 2286, + "Positive %": 10.45, + "Num Positive per mm^2": 891.27 + } +} \ No newline at end of file diff --git a/323/TumorCenter_CD3_block16_x2_y1_patient323_1.json b/323/TumorCenter_CD3_block16_x2_y1_patient323_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1842116e49969d3666d73f5cf3099b338c4668fa --- /dev/null +++ b/323/TumorCenter_CD3_block16_x2_y1_patient323_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7845.8, + "Centroid Y µm": 2448.7, + "Num Detections": 21674, + "Num Negative": 20193, + "Num Positive": 1481, + "Positive %": 6.833, + "Num Positive per mm^2": 558.78 + } +} \ No newline at end of file diff --git a/323/TumorCenter_CD8_block16_x1_y1_patient323_0.json b/323/TumorCenter_CD8_block16_x1_y1_patient323_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a848b05216fc487ef45d56c26f0ade15ae579c2f --- /dev/null +++ b/323/TumorCenter_CD8_block16_x1_y1_patient323_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 2573.6, + "Num Detections": 21701, + "Num Negative": 19057, + "Num Positive": 2644, + "Positive %": 12.18, + "Num Positive per mm^2": 1039.2 + } +} \ No newline at end of file diff --git a/323/TumorCenter_CD8_block16_x2_y1_patient323_1.json b/323/TumorCenter_CD8_block16_x2_y1_patient323_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d61d9f42a2f1b5570b6373f2ae3417d5e5de84e7 --- /dev/null +++ b/323/TumorCenter_CD8_block16_x2_y1_patient323_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 2573.6, + "Num Detections": 24310, + "Num Negative": 23162, + "Num Positive": 1148, + "Positive %": 4.722, + "Num Positive per mm^2": 434.39 + } +} \ No newline at end of file diff --git a/323/history_text.txt b/323/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..93b721c4f37c3fc45b7ef39ed6e76d7758af6838 --- /dev/null +++ b/323/history_text.txt @@ -0,0 +1 @@ + initially <2014> presented to our university outpatient clinic with a mass on the underside of the tongue that had been present for approx. 5 days. The biopsy of the mass on the underside of the tongue showed histologically detectable infiltrates of a moderately differentiated, small focal and keratinizing squamous cell carcinoma. Sonographically, no space-occupying lesion could be visualized on the floor of the mouth with a cN0 neck status; in addition, a primarily non-suspicious mass of the thyroid gland on the right side measuring 24 x 16 x 24 mm was found sonographically. Therefore, indication to perform a panendoscopy with excision of the histologically confirmed malignant mass on the underside of the tongue. However, after consultation with , a coarse needle biopsy of the right-sided thyroid nodule was initially not performed during the operation as the patient's malignant disease should be treated first. \ No newline at end of file diff --git a/323/icd_codes.txt b/323/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d3519fb196715366fd2dd4e8ba4628469459c43 --- /dev/null +++ b/323/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] Bösartige Neubildung der Zungenunterfläche[C02.2 ] \ No newline at end of file diff --git a/323/ops_codes.txt b/323/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..18ecd3c8aa33d0d6018a154e2db75740d7428e82 --- /dev/null +++ b/323/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/323/patient_clinical_data.json b/323/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b078f8d5c5945cc7bd1241d60332e10e570e28c5 --- /dev/null +++ b/323/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 60, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/323/patient_pathological_data.json b/323/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..aa4c5c0511713b8a75839efffcd39f556b2c71ef --- /dev/null +++ b/323/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "323", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/323/surgery_description.txt b/323/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d47c145165f87da209fea300d98bfd9793a9a34 --- /dev/null +++ b/323/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy with excisional biopsy diff --git a/323/surgery_report.txt b/323/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b1923982a0f954034fa9fd34c106c3ac55fd5b8 --- /dev/null +++ b/323/surgery_report.txt @@ -0,0 +1 @@ +After problem-free induction of anesthesia by the anesthesia colleagues, a rigid tracheoscopy is performed first. For this purpose, an O° scope was inserted and the trachea inspected, which was free, non-irritated and clearly visible up to the carina. Finally, withdrawal of the rigid endoscope if there is no evidence of an exophytically growing mass. Removal of the endoscope and intubation by the surgeon. The patient's head is then placed in a low position and a flexible esophagogastroscopy is performed. For this, a flexible endoscope is inserted into the stomach under visualization. A regular mucosal relief can be seen in the stomach. The endoscope is advanced as far as the pylorus, where conditions are also unremarkable. Then carefully withdraw the flexible endoscope and inspect the esophago-gastric junction. Discrete signs of chronic reflux esophagitis. However, no evidence of an exophytic or ulcerating mass. Then careful withdrawal of the flexible endoscope and inspection of the esophagus, here as far as possible inconspicuous mucosal conditions. Then remove the flexible endoscope, insert a mouth guard and perform a pharyngo- and laryngoscopy. For this purpose, a Kleinsasser C-tube is inserted and the oral cavity region, the floor of the mouth and the upper pharyngeal sections are inspected. A slightly spherical and broad-based, rough mass approx. 1 x 1 cm on the median underside of the tongue sitting directly on the frenulum lingulae, which also shows a cone-shaped extension towards the carunculae. The rest of the floor of the mouth as well as the tongue, oral vestibule, tonsillar lobes, palatal arches and uvula are intact and without irritation. The deeper pharynx with the posterior pharyngeal wall region, the piriform sinus entrances and hypopharyngeal walls on both sides are also unremarkable and without irritation. The arytenoid region, aryepiglottic fold and epiglottis are also non-irritant and inconspicuous. The glottis itself is also non-irritating and inconspicuous. Then removal of the Kleinsasser C-tube and the mouth guard and finally turning to the tumorous mass. First demonstration of findings on . First, an anterior duct incision of the wharton's duct is performed on both sides after the tumor reaches the caruculae with an extension. The duct is slit on both sides without any problems. The slit duct section is marsupialized. The mass is then successively removed in toto with the scissors with a sufficiently wide safety margin and bipolar coagulation of the feeding vessels. The marsupialized duct tissue is spared. The preparation is then thread-marked for final histology. Extensive hemostasis by means of bipolar coagulation with absolutely dry wound conditions, then termination of the procedure with repositioning of the patient's head. Summarizing remarks: During the operation, a panendoscopy was performed with unremarkable findings and an excision in toto of the already confirmed squamous cell carcinoma on the underside of the tongue. In addition, an anterior duct incision of the wharton's duct was performed on both sides. The patient was advised to undergo intensive gland massage postoperatively. Waiting for the definitive histology, if necessary resection and initially further thyroid clarification by means of a scintigraphy before planning a coarse needle biopsy. \ No newline at end of file diff --git a/324/InvasionFront_CD3_block11_x5_y2_patient324_0.json b/324/InvasionFront_CD3_block11_x5_y2_patient324_0.json new file mode 100644 index 0000000000000000000000000000000000000000..487ef9c759def18e2e761c22466b926d447a6d86 --- /dev/null +++ b/324/InvasionFront_CD3_block11_x5_y2_patient324_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15466.8, + "Centroid Y µm": 4972.4, + "Num Detections": 20394, + "Num Negative": 20290, + "Num Positive": 104, + "Positive %": 0.51, + "Num Positive per mm^2": 45.52 + } +} \ No newline at end of file diff --git a/324/InvasionFront_CD3_block11_x6_y2_patient324_1.json b/324/InvasionFront_CD3_block11_x6_y2_patient324_1.json new file mode 100644 index 0000000000000000000000000000000000000000..052ffa6e18caac14744bec395c48ac4b1a20a694 --- /dev/null +++ b/324/InvasionFront_CD3_block11_x6_y2_patient324_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 4972.4, + "Num Detections": 21403, + "Num Negative": 21286, + "Num Positive": 117, + "Positive %": 0.5467, + "Num Positive per mm^2": 51.94 + } +} \ No newline at end of file diff --git a/324/InvasionFront_CD8_block11_x5_y2_patient324_0.json b/324/InvasionFront_CD8_block11_x5_y2_patient324_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2801efa3f7c812236d4b31ca72f2a289a522c495 --- /dev/null +++ b/324/InvasionFront_CD8_block11_x5_y2_patient324_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18930.7, + "Centroid Y µm": 15510.1, + "Num Detections": 18386, + "Num Negative": 18367, + "Num Positive": 19, + "Positive %": 0.1033, + "Num Positive per mm^2": 8.743 + } +} \ No newline at end of file diff --git a/324/InvasionFront_CD8_block11_x6_y2_patient324_1.json b/324/InvasionFront_CD8_block11_x6_y2_patient324_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1e01938b9b5f4aae6e87ff14c21e0e885b9acb5d --- /dev/null +++ b/324/InvasionFront_CD8_block11_x6_y2_patient324_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21185.0, + "Centroid Y µm": 15711.2, + "Num Detections": 4427, + "Num Negative": 4423, + "Num Positive": 4, + "Positive %": 0.0904, + "Num Positive per mm^2": 7.333 + } +} \ No newline at end of file diff --git a/324/TumorCenter_CD3_block11_x5_y2_patient324_0.json b/324/TumorCenter_CD3_block11_x5_y2_patient324_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a311cb5831f4ec1f5fbe58e2e6a6b04b0f6f1919 --- /dev/null +++ b/324/TumorCenter_CD3_block11_x5_y2_patient324_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19689.6, + "Centroid Y µm": 5147.3, + "Num Detections": 19292, + "Num Negative": 19244, + "Num Positive": 48, + "Positive %": 0.2488, + "Num Positive per mm^2": 20.99 + } +} \ No newline at end of file diff --git a/324/TumorCenter_CD3_block11_x6_y2_patient324_1.json b/324/TumorCenter_CD3_block11_x6_y2_patient324_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3dd55c87f5317f6c942990e438d899c08b12cb3 --- /dev/null +++ b/324/TumorCenter_CD3_block11_x6_y2_patient324_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 22113.3, + "Centroid Y µm": 5347.2, + "Num Detections": 15633, + "Num Negative": 15573, + "Num Positive": 60, + "Positive %": 0.3838, + "Num Positive per mm^2": 29.11 + } +} \ No newline at end of file diff --git a/324/TumorCenter_CD8_block11_x5_y2_patient324_0.json b/324/TumorCenter_CD8_block11_x5_y2_patient324_0.json new file mode 100644 index 0000000000000000000000000000000000000000..06734c696e5b9b34f9cb7f698abbeb0627ee4885 --- /dev/null +++ b/324/TumorCenter_CD8_block11_x5_y2_patient324_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16991.0, + "Centroid Y µm": 4997.4, + "Num Detections": 20849, + "Num Negative": 20709, + "Num Positive": 140, + "Positive %": 0.6715, + "Num Positive per mm^2": 59.51 + } +} \ No newline at end of file diff --git a/324/TumorCenter_CD8_block11_x6_y2_patient324_1.json b/324/TumorCenter_CD8_block11_x6_y2_patient324_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7df1acd0ecf004d2b207a440fd13f84e36e8cd6a --- /dev/null +++ b/324/TumorCenter_CD8_block11_x6_y2_patient324_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19489.7, + "Centroid Y µm": 5022.3, + "Num Detections": 19146, + "Num Negative": 19065, + "Num Positive": 81, + "Positive %": 0.4231, + "Num Positive per mm^2": 35.74 + } +} \ No newline at end of file diff --git a/324/history_text.txt b/324/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/324/icd_codes.txt b/324/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f6cf9e658acd85ca3621a1a9e548632b9a227f10 --- /dev/null +++ b/324/icd_codes.txt @@ -0,0 +1 @@ +Neubildung bösartig Hypopharynx sonstige[C13.8 ] \ No newline at end of file diff --git a/324/ops_codes.txt b/324/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0e1d541d5bfde57700ed1dc2c767b22f4edbf2dc --- /dev/null +++ b/324/ops_codes.txt @@ -0,0 +1 @@ +Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Laryngopharyngektomie und Schilddrüsenresektion mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.24 ] Wechsel vaskuläres Implantat[5-394.3 ] Anlage oder Wechsel System zur Vakuumversiegelung Tiefreichend, an Knochen und Gelenken der Extremitäten[5-916.a1 L] Kontinuierliche Sogbehandlung bei Vakuumversiegelung Bis 7 Tage[8-190.10 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Temporäre Tracheotomie[5-311.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] \ No newline at end of file diff --git a/324/patient_clinical_data.json b/324/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f7c3d2f3af095345f593bcc5db13d16d162a8f35 --- /dev/null +++ b/324/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 69, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 63, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/324/patient_pathological_data.json b/324/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e0554c6ddc41b08494eb4494e144de2dc13a30f6 --- /dev/null +++ b/324/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "324", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/324/surgery_description.txt b/324/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..50ede466b6d490996c030f61ea43c636db603f11 --- /dev/null +++ b/324/surgery_description.txt @@ -0,0 +1 @@ +Pharyngectomy, Reconstruction, Defect coverage, Free flap (Radial), Tracheostomy, Diagnostic MLE (Microlaryngoscopy and Endoscopy) diff --git a/324/surgery_report.txt b/324/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..53b0cc3123cf1cf9023a2edefc1edd81ddf6bf51 --- /dev/null +++ b/324/surgery_report.txt @@ -0,0 +1 @@ +First, a diagnostic laryngoscopy is performed to re-inspect the tumor findings. This reveals extensive tumor growth, starting at the posterior pharyngeal wall, at the level of the epiglottis, occupying the entire postcricoid, but leaving the arytenoid humps exposed for more than 1 cm each. The tumor extends through both piriform recesses to the esophageal entrance. Due to the fact that the larynx is not completely covered and the medial piriform recess is not reached by the tumor on either side, the decision is made to preserve the larynx and to perform a complete pharyngectomy in the sense of tumor resection via lateral pharyngotomy from the right. A Gluck-Soerensen incision is now made and the right cervical vascular nerve sheath is dissected. Due to the previous operations and the radiotherapy, a correspondingly scarred picture is seen. Nevertheless, the internal jugular vein and the common carotid artery, bulb, external and internal arteries can be fully visualized. The external artery still shows the superior thyroid artery and the maxillary lingual and facial arteries as outlets. The hypoglossal nerve is also exposed and spared. The hyoid bone is now further dissected and half the hyoid bone is removed for further resection and treatment. Half of the thyroid cartilage is also skeletonized on the right side and the hypopharynx is released. Strict care is taken to ensure that no lesions occur, particularly in the area of the anterior thyroid cartilage. However, as already mentioned, the right thyroid cartilage is removed for further resection of the tumor while preserving the bow. This is followed by a pharyngotomy from the right above the hyoid bone and exposure of the underlying tumor. Complete bypass of the tumor in the area of the posterior pharyngeal wall and complete pharyngectomy in the sense of a circular pharyngeal resection, leaving postcricoid mucosa of approx. 1 cm below the arytenoid cartilage. The remaining tissue is now completely removed and traced down to the esophageal entrance. Approx. 2 cm of the esophageal entrance is also resected due to the tumor growth ending 1 cm above it. The esophagus is fixed with sutures to enable later reanastomization and reconstruction with the flap graft. Quick incisions are taken, which are finally reported as tumor-free. Furthermore, the radialis graft to be lifted is now measured for reconstruction. The result is a modified trapezoidal graft measuring 11 by 8 cm and 6 cm in length. This is then incorporated circularly in the form of a funnel. A small, so-called flap key is formed in the area of the esophagus to prevent subsequent re-stenosis in this area. The graft on the left forearm is now lifted in a bloodless state in the typical manner. Once the graft has been removed and the bleeding has been stopped, it is gradually incorporated, first in the area of the esophageal entrance and then in the hypo-/oropharyngeal area. This ensures good and complete wound closure. In order to mobilize the larynx slightly cranially towards the base of the tongue, the cricoid cartilage is now grasped submucosally with a 0 suture and sutured to the base of the tongue, taking the remaining hyoid bone with it. This results in a clearly visible cranial displacement of the larynx, which should enable the patient to swallow more easily. After closure, the anastomosis is performed accordingly. This involves an end-to-end anastomosis of the lingual artery with the radial artery using single button sutures and an end-to-side anastomosis using a 3.5 mm vascular couplas. Finally, good vascular flow is established and the skin and subcutaneous sutures are applied. As part of the skin suture, the skin monitor of the flap is also integrated into the neck wound. Finally, the Doppler signals are checked, which are documented and are good. Parallel to the incorporation of the flap, lifts the full-thickness skin in the area of the right groin and incorporates it in the area of the left forearm to cover the lifting defect. A vacuum seal is now applied and activated. Application of a Cramer splint to immobilize the forearm and hand. Finally, reintubation to a Rüsch cannula and suturing of the cannula \ No newline at end of file diff --git a/325/InvasionFront_CD3_block15_x5_y9_patient325_0.json b/325/InvasionFront_CD3_block15_x5_y9_patient325_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8859bfde552bcff2d53dfaaae20d29780619b3b6 --- /dev/null +++ b/325/InvasionFront_CD3_block15_x5_y9_patient325_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 32357.9, + "Num Detections": 13004, + "Num Negative": 12721, + "Num Positive": 283, + "Positive %": 2.176, + "Num Positive per mm^2": 136.49 + } +} \ No newline at end of file diff --git a/325/InvasionFront_CD3_block15_x6_y9_patient325_1.json b/325/InvasionFront_CD3_block15_x6_y9_patient325_1.json new file mode 100644 index 0000000000000000000000000000000000000000..88ed61a78eb4a8a5f4a112448a6d8d5d3df8b8cd --- /dev/null +++ b/325/InvasionFront_CD3_block15_x6_y9_patient325_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21363.7, + "Centroid Y µm": 32133.0, + "Num Detections": 19387, + "Num Negative": 19097, + "Num Positive": 290, + "Positive %": 1.496, + "Num Positive per mm^2": 131.42 + } +} \ No newline at end of file diff --git a/325/InvasionFront_CD8_block15_x5_y9_patient325_0.json b/325/InvasionFront_CD8_block15_x5_y9_patient325_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b624a6bbdd12733c2b493185bfef14b77f03386 --- /dev/null +++ b/325/InvasionFront_CD8_block15_x5_y9_patient325_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16554.0, + "Centroid Y µm": 22110.3, + "Num Detections": 8757, + "Num Negative": 8613, + "Num Positive": 144, + "Positive %": 1.644, + "Num Positive per mm^2": 74.9 + } +} \ No newline at end of file diff --git a/325/InvasionFront_CD8_block15_x6_y9_patient325_1.json b/325/InvasionFront_CD8_block15_x6_y9_patient325_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd4a77c9b4b31ea6712b433f58981283a637aeab --- /dev/null +++ b/325/InvasionFront_CD8_block15_x6_y9_patient325_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19032.2, + "Centroid Y µm": 21934.8, + "Num Detections": 11558, + "Num Negative": 11263, + "Num Positive": 295, + "Positive %": 2.552, + "Num Positive per mm^2": 160.92 + } +} \ No newline at end of file diff --git a/325/TumorCenter_CD3_block15_x5_y9_patient325_0.json b/325/TumorCenter_CD3_block15_x5_y9_patient325_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b3f01ed1406c298e68f22d819e5c4c13e8bb7615 --- /dev/null +++ b/325/TumorCenter_CD3_block15_x5_y9_patient325_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 26011.2, + "Num Detections": 10541, + "Num Negative": 10488, + "Num Positive": 53, + "Positive %": 0.5028, + "Num Positive per mm^2": 25.19 + } +} \ No newline at end of file diff --git a/325/TumorCenter_CD3_block15_x6_y9_patient325_1.json b/325/TumorCenter_CD3_block15_x6_y9_patient325_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8b743ed5317f1b3b0ae77fe82939366e5b4ef57c --- /dev/null +++ b/325/TumorCenter_CD3_block15_x6_y9_patient325_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 26061.2, + "Num Detections": 11631, + "Num Negative": 11615, + "Num Positive": 16, + "Positive %": 0.1376, + "Num Positive per mm^2": 7.279 + } +} \ No newline at end of file diff --git a/325/TumorCenter_CD8_block15_x5_y9_patient325_0.json b/325/TumorCenter_CD8_block15_x5_y9_patient325_0.json new file mode 100644 index 0000000000000000000000000000000000000000..95470a8e97b8674620806ecc9b040bb2ec06227d --- /dev/null +++ b/325/TumorCenter_CD8_block15_x5_y9_patient325_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 22488.1, + "Num Detections": 13448, + "Num Negative": 13432, + "Num Positive": 16, + "Positive %": 0.119, + "Num Positive per mm^2": 7.395 + } +} \ No newline at end of file diff --git a/325/TumorCenter_CD8_block15_x6_y9_patient325_1.json b/325/TumorCenter_CD8_block15_x6_y9_patient325_1.json new file mode 100644 index 0000000000000000000000000000000000000000..79fe9c136b0124d543cbb86caf9bc92f442b0435 --- /dev/null +++ b/325/TumorCenter_CD8_block15_x6_y9_patient325_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21288.7, + "Centroid Y µm": 22488.1, + "Num Detections": 13493, + "Num Negative": 13463, + "Num Positive": 30, + "Positive %": 0.2223, + "Num Positive per mm^2": 13.78 + } +} \ No newline at end of file diff --git a/325/history_text.txt b/325/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b406d4f5bf014103974456ddef3c0bb879b1adcf --- /dev/null +++ b/325/history_text.txt @@ -0,0 +1 @@ +During a panendoscopy <2014>, a squamous cell carcinoma was histologically confirmed in the patient in the area of the underside of the tongue on the left, so that the indication for surgical treatment with neck dissection on both sides, with a sonographic neck status of at least cN1, was given. \ No newline at end of file diff --git a/325/icd_codes.txt b/325/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d2a13b863b417c1f4c347072498564a81fc2efa --- /dev/null +++ b/325/icd_codes.txt @@ -0,0 +1 @@ +Karzinom der ventralen Zunge[C02.2 ] \ No newline at end of file diff --git a/325/ops_codes.txt b/325/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ecef977146cb644b39c5eebde14350ac9f79d860 --- /dev/null +++ b/325/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 L] Selektive Neck dissection in 4 Regionen[5-403.03 R] Perkutan-endoskopische Gastrostomie[5-431.2 ] \ No newline at end of file diff --git a/325/patient_clinical_data.json b/325/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0c9a533699a150e90e07f3e3c84fe7c001e3a883 --- /dev/null +++ b/325/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/325/patient_pathological_data.json b/325/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cc6c30cc77fc0b74dcc4353b78d1977168b52e01 --- /dev/null +++ b/325/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "325", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/325/surgery_description.txt b/325/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..278e6b7e7d0e179aa3737ecef5d16dd890ef098b --- /dev/null +++ b/325/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Bilateral neck dissection, PEG placement diff --git a/325/surgery_report.txt b/325/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed2f16ae0cdb945e93685a679d67b2e1ac1f0723 --- /dev/null +++ b/325/surgery_report.txt @@ -0,0 +1 @@ +Initially start with PEG insertion: For this purpose, insertion with the gastroscope under laryngoscopic control. Easy pre-scopy into the stomach. Here, with excellent diaphanoscopy, problem-free puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. The oesophagus is inconspicuous on reflection. Repositioning of the patient for transoral tumor resection. Insertion of the open mouth blocker. Re-inspection: The exophytic tumor process can be seen in the area of the underside of the tongue on the left side. The anterior floor of the mouth is not reached. Small leukoplakic extensions in the surrounding area, but with a relatively well-defined tumor process. Incision around the tumor with a safety margin of 1 cm. Depth infiltration approx. 0.5 cm. Involvement of the tongue muscles. The excretory duct can remain intact. The resectate is thread-marked for frozen section diagnostics and is diagnosed as completely tumor-free in the area of the margins. Careful hemostasis. Repositioning of the patient for neck dissection. Injection of xylocaine with added adrenaline. Submandibular skin incision and start with the left side. Cut through skin and subcutaneous tissue. Separation and dissection of the platysma. Exposure of the sternocleidomastoid muscle, omohyoid muscle and digastric muscle. Exposure and preservation of the external jugular vein. Exposure of the digastric muscle does not reveal a truly pronounced submandibular gland. Therefore, elevation of the ramus marginalis mandibulae and clearing of level Ib. The anterior margin shows a clearly suspicious lesion without surrounding infiltration. Removal of level Ib. Exposure of the anterior venter of the digastric muscle. Complete evacuation of level Ia via the left side. Complete the neck dissection, exposing and preserving the facial vein, the superior thyroid artery, the cervical artery and the hypoglossal nerve. Exposure of the accessory nerve. Clearing of the accessorius triangle. Here there are conspicuous changes in both Level IIa and Level IIb, especially in Level IIa clinically metastatic lesions. Clearing of level V with careful protection of the cervical plexus branches. Clearing up to the transition to level Vb. No evidence of lymphatic leakage caudally. Careful exposure of the internal jugular vein, common carotid artery and vagus nerve. Final wound inspection, wound irrigation. Turn to the opposite side. After exposing the muscular borders, the submandibular gland is regularly exposed. Evacuation of level Ib with careful protection of the ramus marginalis mandibulae. Then complete to level Ia. Clearing of levels IIa to IV with careful preservation of the facial vein, the superior thyroid artery and the cervical sinus. Exposure and preservation of the accessorius nerve. Limitation of the extension towards level V. No further measures and no suspicious nodes. Careful wound irrigation. If the wound is dry, final inspection of the wound cavities. Insertion of a 10-gauge Redon drain and careful two-layer wound closure. Final enoral inspection and, if the wound is dry, completion of the procedure without any indication of complications. Conclusion: Intraoperative R0-resected cT2 cN2b oral cavity carcinoma in the area of the underside of the tongue on the left. After receiving the definitive histology, adjuvant therapy was also determined with regard to the secondary diagnosis of TBC disease. \ No newline at end of file diff --git a/326/InvasionFront_CD3_block4_x1_y10_patient326_0.json b/326/InvasionFront_CD3_block4_x1_y10_patient326_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1873e6e03a728ae9c89f8a3e0dd5780a58619fbb --- /dev/null +++ b/326/InvasionFront_CD3_block4_x1_y10_patient326_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 30933.6, + "Num Detections": 20207, + "Num Negative": 16830, + "Num Positive": 3377, + "Positive %": 16.71, + "Num Positive per mm^2": 1511.8 + } +} \ No newline at end of file diff --git a/326/InvasionFront_CD3_block4_x2_y10_patient326_1.json b/326/InvasionFront_CD3_block4_x2_y10_patient326_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9a16007cfdb3922d1f8b85ff47baff123e1bb662 --- /dev/null +++ b/326/InvasionFront_CD3_block4_x2_y10_patient326_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8745.4, + "Centroid Y µm": 30883.6, + "Num Detections": 18184, + "Num Negative": 16251, + "Num Positive": 1933, + "Positive %": 10.63, + "Num Positive per mm^2": 915.66 + } +} \ No newline at end of file diff --git a/326/InvasionFront_CD8_block4_x1_y10_patient326_0.json b/326/InvasionFront_CD8_block4_x1_y10_patient326_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a2c7a2b648d632e2f58b1a485cc7828111e0097f --- /dev/null +++ b/326/InvasionFront_CD8_block4_x1_y10_patient326_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 30009.1, + "Num Detections": 22715, + "Num Negative": 22020, + "Num Positive": 695, + "Positive %": 3.06, + "Num Positive per mm^2": 300.83 + } +} \ No newline at end of file diff --git a/326/InvasionFront_CD8_block4_x2_y10_patient326_1.json b/326/InvasionFront_CD8_block4_x2_y10_patient326_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d20a2960714241cf1ef6bf06dc0a76e79b40f19e --- /dev/null +++ b/326/InvasionFront_CD8_block4_x2_y10_patient326_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 29959.1, + "Num Detections": 19020, + "Num Negative": 18566, + "Num Positive": 454, + "Positive %": 2.387, + "Num Positive per mm^2": 207.28 + } +} \ No newline at end of file diff --git a/326/TumorCenter_CD3_block4_x1_y10_patient326_0.json b/326/TumorCenter_CD3_block4_x1_y10_patient326_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e9e51e6cf2dca815bc5962a2522f2257eeafe90e --- /dev/null +++ b/326/TumorCenter_CD3_block4_x1_y10_patient326_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3748.0, + "Centroid Y µm": 25911.3, + "Num Detections": 21271, + "Num Negative": 19431, + "Num Positive": 1840, + "Positive %": 8.65, + "Num Positive per mm^2": 732.12 + } +} \ No newline at end of file diff --git a/326/TumorCenter_CD3_block4_x2_y10_patient326_1.json b/326/TumorCenter_CD3_block4_x2_y10_patient326_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c5cd6d6741faf3647b5c15bfa20ded49b7049301 --- /dev/null +++ b/326/TumorCenter_CD3_block4_x2_y10_patient326_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 25886.3, + "Num Detections": 17993, + "Num Negative": 14505, + "Num Positive": 3488, + "Positive %": 19.39, + "Num Positive per mm^2": 1606.0 + } +} \ No newline at end of file diff --git a/326/TumorCenter_CD8_block4_x1_y10_patient326_0.json b/326/TumorCenter_CD8_block4_x1_y10_patient326_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c8afcff98862a98ec300dbf43aa10a6b54a621b7 --- /dev/null +++ b/326/TumorCenter_CD8_block4_x1_y10_patient326_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 25411.5, + "Num Detections": 22382, + "Num Negative": 22123, + "Num Positive": 259, + "Positive %": 1.157, + "Num Positive per mm^2": 102.56 + } +} \ No newline at end of file diff --git a/326/TumorCenter_CD8_block4_x2_y10_patient326_1.json b/326/TumorCenter_CD8_block4_x2_y10_patient326_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3ad7ace47f1f244f52e25d3d9e3f672d1d575be0 --- /dev/null +++ b/326/TumorCenter_CD8_block4_x2_y10_patient326_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 25411.5, + "Num Detections": 22220, + "Num Negative": 21114, + "Num Positive": 1106, + "Positive %": 4.977, + "Num Positive per mm^2": 429.39 + } +} \ No newline at end of file diff --git a/326/history_text.txt b/326/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..afcf6a85dd9846dc8f87172ecef7e54ff0e4318e --- /dev/null +++ b/326/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma in the palatal arch area. The above-mentioned operation was therefore indicated. \ No newline at end of file diff --git a/326/icd_codes.txt b/326/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed7f209dbd0540e68399df37e33c3572032cab10 --- /dev/null +++ b/326/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des weichen Gaumens[C05.1 L] \ No newline at end of file diff --git a/326/ops_codes.txt b/326/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f9b03aa0bbce845278b020f8e9d3e44f21c6854d --- /dev/null +++ b/326/ops_codes.txt @@ -0,0 +1 @@ +Partielle Exzision am weichen Gaumen[5-272.1 ] Sonstige Tonsillektomie[5-281.x ] \ No newline at end of file diff --git a/326/patient_clinical_data.json b/326/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..171a2399d4cba5186549a9a206780a833e9b032c --- /dev/null +++ b/326/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/326/patient_pathological_data.json b/326/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b3008938f25a1fbe3a458f1735f69893a37feeb6 --- /dev/null +++ b/326/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "326", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/326/surgery_description.txt b/326/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ffcd8fd28d4049e3fb35919749f5232e4dbc88a0 --- /dev/null +++ b/326/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection diff --git a/326/surgery_report.txt b/326/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e08efa8e35ae8dc79a4f85ea32b9753bae4e19b1 --- /dev/null +++ b/326/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia colleagues. First, pharyngoscopy again: Relatively flat, exophytic tumor is seen in the area of the left uvula, growing towards the anterior and posterior palatal arch, but overall rather superficial growth. Now transoral resection: tumor is removed macroscopically on all sides in healthy tissue with a safety margin of 1 cm. The entire tonsil is resected caudally. The specimen is thread-marked and sent for frozen section. Here all margins in healthy tissue. Overall, the findings are now borderline with regard to defect coverage using a radial flap. Anterior and posterior palatal arch partially preserved. Due to this borderline function, decision to refrain from flap coverage for the time being. Wait and see whether regurgitation or dysphagia develops. In any case, neck dissection at intervals of one to two weeks, then with flap coverage if necessary. Finally, careful hemostasis again. On final inspection, no further evidence of blood flow. Final consultation with anesthesia colleagues. Completion of the procedure without complications. \ No newline at end of file diff --git a/327/InvasionFront_CD3_block4_x3_y11_patient327_0.json b/327/InvasionFront_CD3_block4_x3_y11_patient327_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f6c1e4fb89c511e47a800bc20a11b42f385528bc --- /dev/null +++ b/327/InvasionFront_CD3_block4_x3_y11_patient327_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13268.0, + "Centroid Y µm": 33507.3, + "Num Detections": 23752, + "Num Negative": 17922, + "Num Positive": 5830, + "Positive %": 24.55, + "Num Positive per mm^2": 2367.2 + } +} \ No newline at end of file diff --git a/327/InvasionFront_CD3_block4_x4_y11_patient327_1.json b/327/InvasionFront_CD3_block4_x4_y11_patient327_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8a21477ae8a9be620cea197ae94a1d95f1c0105e --- /dev/null +++ b/327/InvasionFront_CD3_block4_x4_y11_patient327_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 33757.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/327/InvasionFront_CD8_block4_x3_y11_patient327_0.json b/327/InvasionFront_CD8_block4_x3_y11_patient327_0.json new file mode 100644 index 0000000000000000000000000000000000000000..89b6adda15873cc7d4bed165f730946bdbc1f817 --- /dev/null +++ b/327/InvasionFront_CD8_block4_x3_y11_patient327_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 32507.8, + "Num Detections": 22360, + "Num Negative": 14725, + "Num Positive": 7635, + "Positive %": 34.15, + "Num Positive per mm^2": 3051.9 + } +} \ No newline at end of file diff --git a/327/InvasionFront_CD8_block4_x4_y11_patient327_1.json b/327/InvasionFront_CD8_block4_x4_y11_patient327_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0694bb310880a2a9646e0ffeaa04b3e45fcd0fa --- /dev/null +++ b/327/InvasionFront_CD8_block4_x4_y11_patient327_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 32757.7, + "Num Detections": 11918, + "Num Negative": 9404, + "Num Positive": 2514, + "Positive %": 21.09, + "Num Positive per mm^2": 1802.4 + } +} \ No newline at end of file diff --git a/327/TumorCenter_CD3_block4_x3_y11_patient327_0.json b/327/TumorCenter_CD3_block4_x3_y11_patient327_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7398000943c4e3449b9ad9a0279afbb3c096fbd4 --- /dev/null +++ b/327/TumorCenter_CD3_block4_x3_y11_patient327_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11269.0, + "Centroid Y µm": 28260.0, + "Num Detections": 16677, + "Num Negative": 14652, + "Num Positive": 2025, + "Positive %": 12.14, + "Num Positive per mm^2": 1011.4 + } +} \ No newline at end of file diff --git a/327/TumorCenter_CD3_block4_x4_y11_patient327_1.json b/327/TumorCenter_CD3_block4_x4_y11_patient327_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eba1d3b20a5b9fcbd1705683b8b4e53ee11d3c1c --- /dev/null +++ b/327/TumorCenter_CD3_block4_x4_y11_patient327_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 28185.1, + "Num Detections": 18365, + "Num Negative": 15533, + "Num Positive": 2832, + "Positive %": 15.42, + "Num Positive per mm^2": 1279.7 + } +} \ No newline at end of file diff --git a/327/TumorCenter_CD8_block4_x3_y11_patient327_0.json b/327/TumorCenter_CD8_block4_x3_y11_patient327_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f235e45b34efa049fd985b4978c2e38507eae967 --- /dev/null +++ b/327/TumorCenter_CD8_block4_x3_y11_patient327_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 28235.1, + "Num Detections": 16119, + "Num Negative": 14417, + "Num Positive": 1702, + "Positive %": 10.56, + "Num Positive per mm^2": 868.73 + } +} \ No newline at end of file diff --git a/327/TumorCenter_CD8_block4_x4_y11_patient327_1.json b/327/TumorCenter_CD8_block4_x4_y11_patient327_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a8e9225e0258cb478585156f638b6498dab6b32 --- /dev/null +++ b/327/TumorCenter_CD8_block4_x4_y11_patient327_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 28285.0, + "Num Detections": 14695, + "Num Negative": 12602, + "Num Positive": 2093, + "Positive %": 14.24, + "Num Positive per mm^2": 1256.4 + } +} \ No newline at end of file diff --git a/327/history_text.txt b/327/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/327/icd_codes.txt b/327/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/327/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/327/ops_codes.txt b/327/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f97d322083dbbf2db16a7a1e90d07f6e5348823d --- /dev/null +++ b/327/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Temporäre Tracheotomie[5-311.0 ] Hemiglossektomie durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] \ No newline at end of file diff --git a/327/patient_clinical_data.json b/327/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..eb8c60371dead6212dd2c5576428f61792576c32 --- /dev/null +++ b/327/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/327/patient_pathological_data.json b/327/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b9dd64a08de3898ee229e1edae9c3ea9c96494bf --- /dev/null +++ b/327/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "327", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 17.0, + "number_of_resected_lymph_nodes": 28, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/327/surgery_description.txt b/327/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ff9108523460de76c13e93f6a3cd1d19f1813474 --- /dev/null +++ b/327/surgery_description.txt @@ -0,0 +1 @@ +Combined transoral-transcervical tumor resection, Radical bilateral neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/327/surgery_report.txt b/327/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..eb99621e788c6a606d5055b8460f63b293f74319 --- /dev/null +++ b/327/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Induction of anesthesia and intubation by the anesthesia colleagues. First of all, insertion with the small water tube and adjustment of the tumor region. The tumor is extremely difficult to position with the small water tube, making laser resection impossible. In addition, the tumor covers large parts of the right base of the tongue and extends laterally to the metastasis coming from the neck, so that laser resection is not recommended for this reason either. In addition, this would result in a very large defect that would be worth covering anyway. Entering with the flexible gastroesophagoscope and pre-scanning into the stomach. Insertion of a PEG using the thread pull-through method. This is successful with good diaphanoscopy. Application of a wound dressing. Start with neck dissection on the right side. The tumor is marked transorally beforehand. Large lymph node conglomerates with infiltration of the sternocleidomastoid muscle can be seen. The sternocleidomastoid muscle is therefore initially removed caudally. Lymph node conglomerates can be dissected from the omohyoid muscle. Dissection of the larynx. First expose the medial digastric muscle or the hypoglossal nerve. Laborious dissection of the lymph nodes from the structures that can initially be preserved. Then dissection of the tendon of the digastric muscle. Then dissection from the dorsal side. Co-resection of the lower parotid pole and removal of the sternocleidomastoid muscle cranially. Exposure of the cervical vascular sheath from the caudal side. Exposure of the internal jugular vein, common carotid artery, later the internal and external carotid artery. The internal jugular vein is infiltrated from the middle and is initially set off caudally and ligated twice. Further dissection cranially along the carotid artery. The internal and external carotid arteries can be dissected, but parts of the branches of the external carotid artery are infiltrated. The superior thyroid artery and lingual artery can be preserved. The facial and superficial temporal arteries must also be removed in the other small branches. The hypoglossal nerve is now massively infiltrated, the nerve is distended. Macroscopically clear infiltration. Separation of the nerve. Further dissection along the internal carotid artery. Here the tumor can be laboriously dissected from the internal carotid artery, as well as from the vagus nerve. Inclusion of the stylohyoid muscle. Cranial separation of the internal jugular vein. However, this is hardened from the wall near the base of the skull, here a marginal sample. Subsequently, further removal of the lymph nodes between the branches of the cervical plexus from level V a and b. Multiple lymph nodes are positive here. Branches of the cervical plexus can be partially preserved, the cranial accessorius nerve must also be severed and removed. Finally, the massive lymph node conglomerate and multiple affected lymph nodes can be removed. Level II to V removal. Soft tissue is removed cranially from the area of the internal carotid artery up to the bifurcation. This soft tissue is carcinoma-positive, as is the marginal sample of the internal jugular vein, which was removed close to the base of the skull. Thus an overall R1 to R2 situation. No further measures due to the involvement of vital structures. Snaring of the superior thyroid artery, the lingual artery and the internal carotid artery. Exposure of the pharyngeal wall. Tumor resection: Exposure of the upper edge of the tumor from the inside. Dissection through the pharyngeal wall under control from the inside and outside. Exposure of the tumor and successive removal of the tumor with a safety margin of 1 to 1.5 cm on all sides, also macroscopically towards the depth. Parts of the pharyngeal wall from the tonsillar lobe and parts of the glossoalveolar junction are removed. Parts of the vallecula are removed caudally, the base of the tongue is largely removed in the caudal and middle section, with the resection extending to just above or partly above the midline. The tumor is removed in its entirety and marked with sutures. As a hardened nodule was noticed cranially when the tumor was removed, which may also have corresponded to the tonsil, a marginal sample is taken from the pharyngeal wall area with remaining parts of the tonsil. In the frozen section, this tumor margin specimen as well as the specimen in the healthy state, relatively scarce in the basal region due to tissue shrinkage, but to be classified as R0 during resection. Neck dissection on the left side. For this purpose, an apron flap is created in the usual manner. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the submandibular gland. Exposure of the digastric and omohyoid muscles. Exposure of the cervical vascular sheath. Exposure of the internal jugular vein. Exposure of the facial vein. Exposure of the superior thyroid artery. Exposure of the accessory nerve and hypoglossal nerve. Displacement and, at the end of the operation, re-embedding of the accessory nerve and hypoglossal nerve in the sense of a neurolysis. Clearing of the neck levels II a to V a while sparing the plexus branches. Several rough, spherical lymph node metastases are clearly visible here, all of which are also removed. After the neck dissection on the left, the tracheotomy is performed. The incision is made at the lower edge of the cricoid cartilage. Dissection down to the thyroid isthmus, which is cut through. Thorough bipolar coagulation. Opening of the trachea between the 2nd and 3rd tracheal cartilage. Creation of a mucocutaneous anastomosis and reintubation. Elevation of the radial forearm flap on the left: Palpatory identification of the distal radial artery. Marking of the flap boundaries (size) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the pronator quadratus and flexor pollicis longus muscles with ligation of the outgoing perforators using a vascular clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Deposition of the radialis graft and preparation of the vascular situation in the elbow. Lifting of split skin on the right thigh. Application of Starsil wound powder and application of a foam dressing. Preparation of the wound bed on the left forearm. For this purpose, the superficial ramus of the radial nerve is embedded laterally into the tissue so that it cannot come into contact with the split skin and is protected. Partial adaptation and reduction of the wound area and suturing of muscles to tendons that are particularly exposed. Fitting of the split-thickness skin graft and suturing of the split-thickness skin graft in the usual manner. At the end, the application of ball swabs to areas where the split skin had no contact with the subsurface. Application and suturing of compresses and application of a dorsal forearm splint. Insertion of the graft, initially transorally. Here the defect extends up to the soft palate and into the tonsillar lumen. The tonsil is also removed. The remaining graft must be sutured in from the transcervical side. Due to the ultimately even larger defect than planned, the pharynx must be partially gathered. However, this is not a problem, so that the graft fits well in the end. The stalk is transferred to the left side; there is no longer a connecting vessel on the right side due to the radical neck dissection. The superior thyroid artery is used on the left side. This is particularly difficult as all other vessels in the neck are very small in caliber, but the radial artery is very large. Therefore, the caliber jump must be specially bridged using suture techniques. The venous anastomosis is performed on the facial vein and the external jugular vein. The flap pedicle has very good pulsation at the end and the flap is well supplied with blood. Insertion of two Redon drains. Application of a pressure dressing on both sides. The patient goes to the intensive care unit intubated and ventilated through the tracheostoma with a size 8.0 tracheostomy tube. Final consultation with the anesthesia department. Please continue postoperative antibiotics for at least 24 hours. Flap checks according to the usual schedule. \ No newline at end of file diff --git a/328/InvasionFront_CD3_block15_x5_y12_patient328_0.json b/328/InvasionFront_CD3_block15_x5_y12_patient328_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ebb48b621b944d8246755422f5924ef70f91102f --- /dev/null +++ b/328/InvasionFront_CD3_block15_x5_y12_patient328_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19139.9, + "Centroid Y µm": 39554.1, + "Num Detections": 11436, + "Num Negative": 10270, + "Num Positive": 1166, + "Positive %": 10.2, + "Num Positive per mm^2": 864.96 + } +} \ No newline at end of file diff --git a/328/InvasionFront_CD3_block15_x6_y12_patient328_1.json b/328/InvasionFront_CD3_block15_x6_y12_patient328_1.json new file mode 100644 index 0000000000000000000000000000000000000000..db55e2a95896d8a48bf6195a29cf043a9d6d7085 --- /dev/null +++ b/328/InvasionFront_CD3_block15_x6_y12_patient328_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21638.5, + "Centroid Y µm": 39529.1, + "Num Detections": 10535, + "Num Negative": 9732, + "Num Positive": 803, + "Positive %": 7.622, + "Num Positive per mm^2": 724.51 + } +} \ No newline at end of file diff --git a/328/InvasionFront_CD8_block15_x5_y12_patient328_0.json b/328/InvasionFront_CD8_block15_x5_y12_patient328_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4babbd4f38e3ce486971b0af023ede54d2594ace --- /dev/null +++ b/328/InvasionFront_CD8_block15_x5_y12_patient328_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16714.6, + "Centroid Y µm": 28963.8, + "Num Detections": 10729, + "Num Negative": 9812, + "Num Positive": 917, + "Positive %": 8.547, + "Num Positive per mm^2": 544.18 + } +} \ No newline at end of file diff --git a/328/InvasionFront_CD8_block15_x6_y12_patient328_1.json b/328/InvasionFront_CD8_block15_x6_y12_patient328_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d20fc2f132db8a740e83fc979f157bd847ab58e4 --- /dev/null +++ b/328/InvasionFront_CD8_block15_x6_y12_patient328_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19141.1, + "Centroid Y µm": 29113.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/328/TumorCenter_CD3_block15_x5_y12_patient328_0.json b/328/TumorCenter_CD3_block15_x5_y12_patient328_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f62860e2fa3711c4b9bb06ecdfab136e7d520432 --- /dev/null +++ b/328/TumorCenter_CD3_block15_x5_y12_patient328_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 33482.3, + "Num Detections": 20773, + "Num Negative": 18363, + "Num Positive": 2410, + "Positive %": 11.6, + "Num Positive per mm^2": 1029.8 + } +} \ No newline at end of file diff --git a/328/TumorCenter_CD3_block15_x6_y12_patient328_1.json b/328/TumorCenter_CD3_block15_x6_y12_patient328_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d29ae840e6bb547ad18d8e8a3a900ee7a49bd86a --- /dev/null +++ b/328/TumorCenter_CD3_block15_x6_y12_patient328_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 33557.2, + "Num Detections": 19012, + "Num Negative": 16796, + "Num Positive": 2216, + "Positive %": 11.66, + "Num Positive per mm^2": 984.62 + } +} \ No newline at end of file diff --git a/328/TumorCenter_CD8_block15_x5_y12_patient328_0.json b/328/TumorCenter_CD8_block15_x5_y12_patient328_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6796583bc653bacd434bdb5a3944ab2ea3497058 --- /dev/null +++ b/328/TumorCenter_CD8_block15_x5_y12_patient328_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 29859.2, + "Num Detections": 19760, + "Num Negative": 15634, + "Num Positive": 4126, + "Positive %": 20.88, + "Num Positive per mm^2": 1751.2 + } +} \ No newline at end of file diff --git a/328/TumorCenter_CD8_block15_x6_y12_patient328_1.json b/328/TumorCenter_CD8_block15_x6_y12_patient328_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2fe886983a77cbad0438a2261d3836138d6ac265 --- /dev/null +++ b/328/TumorCenter_CD8_block15_x6_y12_patient328_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21163.8, + "Centroid Y µm": 29909.2, + "Num Detections": 18616, + "Num Negative": 15298, + "Num Positive": 3318, + "Positive %": 17.82, + "Num Positive per mm^2": 1467.3 + } +} \ No newline at end of file diff --git a/328/history_text.txt b/328/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/328/icd_codes.txt b/328/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bd499c58a417cfc54de3fb3d79d05e5befa06940 --- /dev/null +++ b/328/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 ] \ No newline at end of file diff --git a/328/ops_codes.txt b/328/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b41cbe9a7bf0fb1c493039b294e083f52b6a7930 --- /dev/null +++ b/328/ops_codes.txt @@ -0,0 +1 @@ +Elektrokoagulation Zungengewebe[5-250.30 ] Anwendung eines OP-Roboters (Zusatzkode)[5-987 ] Reoperation (Zusatzkode)[5-983 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 L] PEG-Sonde Anlage[5-431.2 ] \ No newline at end of file diff --git a/328/patient_clinical_data.json b/328/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8d298673406c22c46e75f0c44fd2ef9e27c0fd52 --- /dev/null +++ b/328/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/328/patient_pathological_data.json b/328/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f2b06a8599a8082a4b764dd045b8412cd93e972d --- /dev/null +++ b/328/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "328", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/328/surgery_description.txt b/328/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9c84b7af2a476fa2f6eb0c52603d4d30622a6c7d --- /dev/null +++ b/328/surgery_description.txt @@ -0,0 +1 @@ +TORS procedure for partial glossectomy, Neck dissection diff --git a/328/surgery_report.txt b/328/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f3ab9441cd2d4ea2f459322d40f80f929bf3b2e6 --- /dev/null +++ b/328/surgery_report.txt @@ -0,0 +1 @@ +Inspection and exploration of the oral cavity. An exophytic, partially exulcerated tumor process is seen on the left free edge of the tongue, which extends to approx. 3 x 2 cm, also submucosally with clear deep infiltration with small satellite foci perfocally on the anterior edge, submucosally. After exposure of the tumor, the tumor is cut around with a safety margin of approx. 1.5 cm macroscopically, especially in depth. The tumorous process or resection defect remains confined to the free edge of the tongue, with no significant involvement of the lateral floor of the mouth. The specimen is now thread-marked for frozen section diagnostics. This reveals a narrow resection margin in the area of the anterior tongue body in the area of the perifocal lesions, which is why the resection margin is extended here by a resection. Subsequently, a new completely covering margin sample was performed. Otherwise R0 situation on all sides. Due to the clear wound surface, the wound edges are now adapted with 3-0 Vicryl. Overall, the wound was completely dry and then turned to neck dissection for cN2b neck status, which was performed on the left side due to the strictly unilateral tumor. Dictation : Now neck dissection on the left by and alternately. Head positioning, infiltration with Ultracaine 2% with added Suprarenin. Separation of the skin and platysma, auricular magnus nerve, exposure of the anterior border of the sternocleidomastoid muscle, omohyoid muscle, submandibular muscle, digastric muscle and exposure of the accessorius nerve. Insertion of the blockers and exploration of the internal jugular vein. Exposure to the cranial side, resulting in opening. After vascular suturing using Prolene 6.0, hemostasis. Now the neck preparation is released from cranial to caudal along the cervical vascular sheath from levels II, III and IV, after dissection of level IIb / V while sparing the accessorius nerve. The plexus branches, hypoglossal nerve and facial artery/vein are exposed and preserved. Finally, level IV is removed. Finally, level Ib, clinically no suspicious nodes. Hemostasis with the bipolar. Insertion of a Redon, two-layer wound closure. \ No newline at end of file diff --git a/329/InvasionFront_CD3_block4_x5_y6_patient329_0.json b/329/InvasionFront_CD3_block4_x5_y6_patient329_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a97954db7639e0f00b432e4457759acdfb8d587f --- /dev/null +++ b/329/InvasionFront_CD3_block4_x5_y6_patient329_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 21263.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/329/InvasionFront_CD3_block4_x6_y6_patient329_1.json b/329/InvasionFront_CD3_block4_x6_y6_patient329_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fe32d3b88f84a640e1924e61a23efd700d42b17f --- /dev/null +++ b/329/InvasionFront_CD3_block4_x6_y6_patient329_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21538.6, + "Centroid Y µm": 21363.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/329/InvasionFront_CD8_block4_x5_y6_patient329_0.json b/329/InvasionFront_CD8_block4_x5_y6_patient329_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0711c4f78ee5718a217a20a60639fd8fd210b81e --- /dev/null +++ b/329/InvasionFront_CD8_block4_x5_y6_patient329_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 19889.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/329/InvasionFront_CD8_block4_x6_y6_patient329_1.json b/329/InvasionFront_CD8_block4_x6_y6_patient329_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d00073fb75d2d2dc4b7f50a162d0eb2f3345fa66 --- /dev/null +++ b/329/InvasionFront_CD8_block4_x6_y6_patient329_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19027.4, + "Centroid Y µm": 19964.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/329/TumorCenter_CD3_block4_x5_y6_patient329_0.json b/329/TumorCenter_CD3_block4_x5_y6_patient329_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6c77265430d1abb42522ba162fd7f04ee0849cea --- /dev/null +++ b/329/TumorCenter_CD3_block4_x5_y6_patient329_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 15391.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/329/TumorCenter_CD3_block4_x6_y6_patient329_1.json b/329/TumorCenter_CD3_block4_x6_y6_patient329_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4e1cb52614afc4150eeba56f350140ee438b7884 --- /dev/null +++ b/329/TumorCenter_CD3_block4_x6_y6_patient329_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 15366.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/329/TumorCenter_CD8_block4_x5_y6_patient329_0.json b/329/TumorCenter_CD8_block4_x5_y6_patient329_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a8e6e5a102bbae01da2fa19c7fbb2b5075ded7cc --- /dev/null +++ b/329/TumorCenter_CD8_block4_x5_y6_patient329_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 15616.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/329/TumorCenter_CD8_block4_x6_y6_patient329_1.json b/329/TumorCenter_CD8_block4_x6_y6_patient329_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0f27a582aab940d027332ffc38332ecc69d8f0f3 --- /dev/null +++ b/329/TumorCenter_CD8_block4_x6_y6_patient329_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19264.8, + "Centroid Y µm": 15741.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/329/history_text.txt b/329/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..abe872faf02170ec7a57d3067ccf09d852163c4d --- /dev/null +++ b/329/history_text.txt @@ -0,0 +1 @@ +Patient with histologically proven G3 squamous cell carcinoma cT1 cN2b in the area of the right base of the tongue. Therefore indication for the above measures. \ No newline at end of file diff --git a/329/icd_codes.txt b/329/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..12e580e692f014d16832109ccad28ade45ce168a --- /dev/null +++ b/329/icd_codes.txt @@ -0,0 +1 @@ +Halsmetastase[C79.88 R] \ No newline at end of file diff --git a/329/ops_codes.txt b/329/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f00dafbc79b51ab3dd683fc9881f575f56d0ddee --- /dev/null +++ b/329/ops_codes.txt @@ -0,0 +1 @@ +Exzision erkranktes Gewebe Zunge[5-250.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/329/patient_clinical_data.json b/329/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..13e5dc91c99e6f23e04a514ece47a806adf06335 --- /dev/null +++ b/329/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 71, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/329/patient_pathological_data.json b/329/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1cf3ec805add5f4a18125e452bace81ae2233a0b --- /dev/null +++ b/329/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "329", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 34, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/329/surgery_description.txt b/329/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f55cae052c1f7d32f7e874cdf7853b4cfee5c806 --- /dev/null +++ b/329/surgery_description.txt @@ -0,0 +1 @@ +Pharyngoscopy, Transoral laser resection, and Neck dissection diff --git a/329/surgery_report.txt b/329/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..efdaff88fe4079f9fd8fdea1863ba6c912636ba6 --- /dev/null +++ b/329/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia, transoral-endotracheal intubation by the anesthesia colleagues. Positioning of the patient by the surgeon. Subsequent adjustment of the findings in the area of the right tongue base with the spreading laryngoscope. Setting the CO2 laser to continuous mode with a power of 6 watts and successive traversing of the findings in the area of the right base of the tongue. The tumor specimen is removed in toto. Three marginal samples are then taken (right glossotonsillar groove, lingual epiglottis, medial resection margin). All three are found to be CIS and tumor-free by the pathology colleagues. Hemostasis there by means of monopolar coagulation. Dry conditions. Removal of the spreading laryngoscope. Application of local anesthesia cervically on both sides. Cervical skin ablation on both sides and sterile draping. Repositioning of the patient for neck dissection on the right side. Skin incision along the anterior border of the sternocleidomastoid muscle. Exposure and ligation of the external jugular vein. Exposure and sparing of the auricularis magnus nerve. Exposure of the digaster muscle and the cranial accessorius nerve as well as the caudal omohyoid muscle. Exposure of the capsule of the submandibular gland and the hypoglossal nerve. Subsequent exposure of the internal jugular vein from caudal to cranial and complete dissection of the cervical vascular sheath from the multiple metastases on the right side. Repeated hemostasis using bipolar coagulation. The multiple cervical metastases on the right side can be completely removed while sparing the plexus branches of the accessorius and hypoglossal nerves. Dry conditions. Wound irrigation with hydrogen peroxide and Ringer's solution. Insertion of a 10-gauge Redon drain. Two-layer wound closure. Repositioning of the patient to perform a neck dissection on the left side. Skin incision along the anterior edge of the sternocleidomastoid muscle. Cut through the subcutaneous tissue and the platysma. Exposure and ligation of the external jugular vein. Exposure and sparing of the auricularis magnus nerve. Exposure of the omohyoid muscle caudally as well as the submandibular gland of the digastric muscle and the cranial accessorius nerve. Dissection along the cervical vascular sheath from caudal to cranial up to the digaster muscle. Successive removal of the posterior neck specimen while sparing the accessorius nerve and the plexus branches as well as the anterior neck specimen. There, suspicious lymph nodes in regions II and III on the left side. Hemostasis using bipolar coagulation. Wound irrigation using hydrogen peroxide and Ringer's solution. Insertion of a 10-gauge Redon drain. Two-layer wound closure. Application of a pressure bandage. Completion of the procedure without complications. Please feed via PEG for the next 10 days. Suture removal on the 10th postoperative day. \ No newline at end of file diff --git a/330/InvasionFront_CD3_block18_x3_y2_patient330_0.json b/330/InvasionFront_CD3_block18_x3_y2_patient330_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42dcca598d08bc0126ab86fda9a35c7cb8d7653f --- /dev/null +++ b/330/InvasionFront_CD3_block18_x3_y2_patient330_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11818.7, + "Centroid Y µm": 9569.9, + "Num Detections": 17907, + "Num Negative": 16766, + "Num Positive": 1141, + "Positive %": 6.372, + "Num Positive per mm^2": 549.01 + } +} \ No newline at end of file diff --git a/330/InvasionFront_CD3_block18_x4_y2_patient330_1.json b/330/InvasionFront_CD3_block18_x4_y2_patient330_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b6d95b7c64a9d24c786ab6e676c43fa0641c6130 --- /dev/null +++ b/330/InvasionFront_CD3_block18_x4_y2_patient330_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14442.4, + "Centroid Y µm": 9719.9, + "Num Detections": 17769, + "Num Negative": 17266, + "Num Positive": 503, + "Positive %": 2.831, + "Num Positive per mm^2": 248.94 + } +} \ No newline at end of file diff --git a/330/InvasionFront_CD8_block18_x3_y2_patient330_0.json b/330/InvasionFront_CD8_block18_x3_y2_patient330_0.json new file mode 100644 index 0000000000000000000000000000000000000000..323a6c75a6bdc4bd7c6b1b03a100c9779c18408f --- /dev/null +++ b/330/InvasionFront_CD8_block18_x3_y2_patient330_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11451.2, + "Centroid Y µm": 13033.6, + "Num Detections": 17678, + "Num Negative": 16902, + "Num Positive": 776, + "Positive %": 4.39, + "Num Positive per mm^2": 388.08 + } +} \ No newline at end of file diff --git a/330/InvasionFront_CD8_block18_x4_y2_patient330_1.json b/330/InvasionFront_CD8_block18_x4_y2_patient330_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c49069b9b31838f430a32f398ff9536f3570377 --- /dev/null +++ b/330/InvasionFront_CD8_block18_x4_y2_patient330_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13988.1, + "Centroid Y µm": 13018.8, + "Num Detections": 18257, + "Num Negative": 17935, + "Num Positive": 322, + "Positive %": 1.764, + "Num Positive per mm^2": 159.03 + } +} \ No newline at end of file diff --git a/330/TumorCenter_CD3_block18_x3_y2_patient330_0.json b/330/TumorCenter_CD3_block18_x3_y2_patient330_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6b145001ea29f60a252a12be7a918db10d39290b --- /dev/null +++ b/330/TumorCenter_CD3_block18_x3_y2_patient330_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11114.9, + "Centroid Y µm": 4922.4, + "Num Detections": 18470, + "Num Negative": 18352, + "Num Positive": 118, + "Positive %": 0.6389, + "Num Positive per mm^2": 60.7 + } +} \ No newline at end of file diff --git a/330/TumorCenter_CD3_block18_x4_y2_patient330_1.json b/330/TumorCenter_CD3_block18_x4_y2_patient330_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9668a033458eef74a3f3b70007402a95580c1e5e --- /dev/null +++ b/330/TumorCenter_CD3_block18_x4_y2_patient330_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13565.7, + "Centroid Y µm": 4997.4, + "Num Detections": 14511, + "Num Negative": 14441, + "Num Positive": 70, + "Positive %": 0.4824, + "Num Positive per mm^2": 37.07 + } +} \ No newline at end of file diff --git a/330/TumorCenter_CD8_block18_x3_y2_patient330_0.json b/330/TumorCenter_CD8_block18_x3_y2_patient330_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c9ab68bc2bfd8787c0c075e587ab631fa0d98947 --- /dev/null +++ b/330/TumorCenter_CD8_block18_x3_y2_patient330_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10969.2, + "Centroid Y µm": 5522.1, + "Num Detections": 19362, + "Num Negative": 19237, + "Num Positive": 125, + "Positive %": 0.6456, + "Num Positive per mm^2": 61.4 + } +} \ No newline at end of file diff --git a/330/TumorCenter_CD8_block18_x4_y2_patient330_1.json b/330/TumorCenter_CD8_block18_x4_y2_patient330_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0ea3a8077b1f9d133fcc171b5ce5bd403615e69 --- /dev/null +++ b/330/TumorCenter_CD8_block18_x4_y2_patient330_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 5572.0, + "Num Detections": 16665, + "Num Negative": 16531, + "Num Positive": 134, + "Positive %": 0.8041, + "Num Positive per mm^2": 66.6 + } +} \ No newline at end of file diff --git a/330/history_text.txt b/330/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/330/icd_codes.txt b/330/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7b3dfc242c7d0270e54c62c7e55e34db0c4a557a --- /dev/null +++ b/330/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/330/ops_codes.txt b/330/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..58bd0df404fea52beac60ea3d010bb36e2d93a78 --- /dev/null +++ b/330/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] PEG durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/330/patient_clinical_data.json b/330/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2452e61933fbf719803569b8f17caeaca4a330f9 --- /dev/null +++ b/330/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 77, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/330/patient_pathological_data.json b/330/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..604192661ddf90f42dead222056fa1becf5b3ebf --- /dev/null +++ b/330/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "330", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/330/surgery_description.txt b/330/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..baccc7b80163bf94eb3f5bcd7d32a8aad764374a --- /dev/null +++ b/330/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, PEG placement, Tracheotomy diff --git a/330/surgery_report.txt b/330/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c7a392b449db6ce8c1f9975ab82fdaa677096050 --- /dev/null +++ b/330/surgery_report.txt @@ -0,0 +1 @@ +Neck dissection on the left by : Skin incision in the area of the apron flap, ending at the anterior edge of the sternocleidomastoid muscle, down to the tracheostoma edge. Cut through the subcutaneous tissue and identify the platysma. Dissection of the platysma and looping of the platysma. Subplatysmal dissection of the apron flap to expose the hyoid bone and the submandibular gland. Suturing of the apron flap and opening of the gland capsule in the caudal gland area. Dissection down to the hyoid bone. The marginal ramus of the facial nerve appears between the gland and the platysma and can be safely spared. Now expose the digaster venter posterior muscle and insert the Breitenbeck. Dissection of region II. Dissection along the sternocleidomastoid muscle down to the depths until the accessorius nerve is exposed, which is freed from the neck preparation. Dissection down to the deep plexus branches without damaging them. Identification of the omohyoid muscle in region III/IV and dissection along the muscle to the hyoid bone. Clearing of region III and IV. Sharp dissection on the internal jugular vein and freeing of the neck preparation from the vascular nerve sheath. This preserves all nerve and vascular structures. The lymph nodes are also removed from the posterior edge of the sternocleidomastoid muscle in the sense of a neck dissection in region V. Now resect the neck preparation in the usual way from cranial to caudal, sparing the deep plexus branches and the accessorius nerve. Enter the vessels medially and expose the common carotid artery, the carotid bifurcation, the superior thyroid artery and the facial artery. Now free the vascular nerve sheath from the larynx. Separate the infrahyoid musculature and strike the musculature downwards. Expose and remove prelaryngeal region VI. Identification of the hyoid bone and separation of the hyoid bone from the suprahyoid musculature. Neck dissection on the right by : Exposure of the anterior edge of the sternocleidomastoid muscle and dissection in depth. Exposure of the omohyoid muscle and the submandibular gland. The submandibular gland is pulled upwards with the Langenbeck to protect the marginal ramus. Exposure of the posterior venter of the digastric muscle and of region II. A large metastasis can be seen in region II b, which extends to the mandible, displaces the accessorius nerve and is also attached to the internal jugular vein. This is carefully and successively dissected away, sparing all these structures. Exposing the cervical vascular sheath and exposing the lymph nodes from region II to IV. Finding the hypoglossal nerve and protecting it. Securing the vagus nerve and protecting it. Now clear the lateral neck preparation in the sense of a neck dissection from region II to IV. Region V at the posterior margin of the MSCM is also exposed and cleared while preserving the brachial plexus. Now clear the medial neck preparation up to region VI prelaryngeally. Detach the prelaryngeal musculature from the larynx and expose the hyoid bone using an electric knife. Release of the larynx on the right side. A thyroid gland can no longer be identified in the inflammatory tissue if the tracheostoma is clearly scarred. The tissue is removed to ensure good epithelialization of the tracheostoma. TSH, T3 and T4 checks should be carried out postoperatively. Laryngectomy by : After completion of the bilateral neck dissection, detachment of the internal carotid artery from the hypopharynx on both sides. Firstly, separation of the larynx under the cricoid cartilage. Then expose the pre-epiglottic fat body and dissect the lingual epiglottis cranially up to its free edge. There it enters the hypopharynx. Now the larynx is successively released under visualization of the predominantly intralaryngeal tumor. The piriform sinuses, which were previously released, can be spared. The two lateral resections are combined caudal to the two arytenoid humps so that the larynx can now be completely removed. Circular mucosal samples are taken from the resulting defect in the pharynx, all of which are found to be tumor-free on frozen section histology. The myotomy is then performed. At the patient's request, a Provox device is not used. The T-shaped closure of the neopharynx is then performed using a first continuous suture according to Conley. The second layer is a single button suture. Redon suction drains are then inserted on both sides, the epithelialized tracheostoma is completed and the wound is closed in several layers on both sides. \ No newline at end of file diff --git a/331/InvasionFront_CD3_block11_x3_y5_patient331_0.json b/331/InvasionFront_CD3_block11_x3_y5_patient331_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2e83f3068fc4795c7941dc336586c1d7910a0bb4 --- /dev/null +++ b/331/InvasionFront_CD3_block11_x3_y5_patient331_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10544.4, + "Centroid Y µm": 12143.6, + "Num Detections": 20287, + "Num Negative": 19595, + "Num Positive": 692, + "Positive %": 3.411, + "Num Positive per mm^2": 298.64 + } +} \ No newline at end of file diff --git a/331/InvasionFront_CD3_block11_x4_y5_patient331_1.json b/331/InvasionFront_CD3_block11_x4_y5_patient331_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f3c4e0e68fa3e0b674a36f5727a04c2bb4769b36 --- /dev/null +++ b/331/InvasionFront_CD3_block11_x4_y5_patient331_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13093.1, + "Centroid Y µm": 12093.6, + "Num Detections": 20209, + "Num Negative": 19113, + "Num Positive": 1096, + "Positive %": 5.423, + "Num Positive per mm^2": 472.1 + } +} \ No newline at end of file diff --git a/331/InvasionFront_CD8_block11_x3_y5_patient331_0.json b/331/InvasionFront_CD8_block11_x3_y5_patient331_0.json new file mode 100644 index 0000000000000000000000000000000000000000..95d1059e3407e80433c31f79897876444ae72151 --- /dev/null +++ b/331/InvasionFront_CD8_block11_x3_y5_patient331_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13711.4, + "Centroid Y µm": 23069.6, + "Num Detections": 15340, + "Num Negative": 15057, + "Num Positive": 283, + "Positive %": 1.845, + "Num Positive per mm^2": 171.09 + } +} \ No newline at end of file diff --git a/331/InvasionFront_CD8_block11_x4_y5_patient331_1.json b/331/InvasionFront_CD8_block11_x4_y5_patient331_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d1ada2cb38a8951a0d1846fcd445496602351018 --- /dev/null +++ b/331/InvasionFront_CD8_block11_x4_y5_patient331_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16136.3, + "Centroid Y µm": 22942.3, + "Num Detections": 15006, + "Num Negative": 14630, + "Num Positive": 376, + "Positive %": 2.506, + "Num Positive per mm^2": 263.69 + } +} \ No newline at end of file diff --git a/331/TumorCenter_CD3_block11_x3_y5_patient331_0.json b/331/TumorCenter_CD3_block11_x3_y5_patient331_0.json new file mode 100644 index 0000000000000000000000000000000000000000..12dacffe9a263a73af800dedbbce7485c67e30d0 --- /dev/null +++ b/331/TumorCenter_CD3_block11_x3_y5_patient331_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14342.4, + "Centroid Y µm": 12443.4, + "Num Detections": 23465, + "Num Negative": 20734, + "Num Positive": 2731, + "Positive %": 11.64, + "Num Positive per mm^2": 1145.9 + } +} \ No newline at end of file diff --git a/331/TumorCenter_CD3_block11_x4_y5_patient331_1.json b/331/TumorCenter_CD3_block11_x4_y5_patient331_1.json new file mode 100644 index 0000000000000000000000000000000000000000..94a92f06b2ad7547d2f85e9e48c0b73f4fa70105 --- /dev/null +++ b/331/TumorCenter_CD3_block11_x4_y5_patient331_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16891.1, + "Centroid Y µm": 12393.4, + "Num Detections": 14136, + "Num Negative": 12641, + "Num Positive": 1495, + "Positive %": 10.58, + "Num Positive per mm^2": 837.8 + } +} \ No newline at end of file diff --git a/331/TumorCenter_CD8_block11_x3_y5_patient331_0.json b/331/TumorCenter_CD8_block11_x3_y5_patient331_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bc7be2015ae4f28207c5e5552ac522a3a5c930e8 --- /dev/null +++ b/331/TumorCenter_CD8_block11_x3_y5_patient331_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11793.8, + "Centroid Y µm": 12393.4, + "Num Detections": 22978, + "Num Negative": 18100, + "Num Positive": 4878, + "Positive %": 21.23, + "Num Positive per mm^2": 1974.6 + } +} \ No newline at end of file diff --git a/331/TumorCenter_CD8_block11_x4_y5_patient331_1.json b/331/TumorCenter_CD8_block11_x4_y5_patient331_1.json new file mode 100644 index 0000000000000000000000000000000000000000..057ed50ee2d6969da3966961a612f6ef2a8950d0 --- /dev/null +++ b/331/TumorCenter_CD8_block11_x4_y5_patient331_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14389.3, + "Centroid Y µm": 12402.0, + "Num Detections": 18012, + "Num Negative": 17267, + "Num Positive": 745, + "Positive %": 4.136, + "Num Positive per mm^2": 374.08 + } +} \ No newline at end of file diff --git a/331/history_text.txt b/331/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/331/icd_codes.txt b/331/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/331/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/331/ops_codes.txt b/331/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b9d4b3121663746f4ed52eadcb208ecf4db1c1f0 --- /dev/null +++ b/331/ops_codes.txt @@ -0,0 +1 @@ +Transplantation sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.93 L] Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 6 Regionen[5-403.05 B] Resektion an der Trachea mit Anlegen eines Tracheostomas[5-314.12 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Diagnostische Pharyngoskopie direkt[1-611.0 ] \ No newline at end of file diff --git a/331/patient_clinical_data.json b/331/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..61145c588b77734b7925b27d7d8ecf29f1dc27ad --- /dev/null +++ b/331/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 58, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/331/patient_pathological_data.json b/331/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..27e653601dbd40a2746cbb37b4a4fb2086f0ca18 --- /dev/null +++ b/331/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "331", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/331/surgery_description.txt b/331/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..680033cc248b5afe58ba212619ce237cc64bdb95 --- /dev/null +++ b/331/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Neck dissection, Free flap (Radial) diff --git a/331/surgery_report.txt b/331/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7f3faf3c2d624962245fa5e628792b6742499b50 --- /dev/null +++ b/331/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and inspection of the tumor findings, which extend submucosally far into the soft palate with a center in the area of the tonsil lobe. Submucosally, the tumor reaches the uvula on palpation and thus the median line of the soft palate. However, it can be differentiated from the hard palate. Furthermore, the tumor extends over the lateral pharyngeal wall, the angle of the jaw, straight onto the base of the tongue and ends caudally just above the lateral wall of the piriform recess. The tumor is now cut around from the enoral side with the monopolar and the scissor blade with an appropriate safety distance of approx. 1 cm. After in toto resection, the specimen is thread-marked and sent for histopathological frozen section evaluation. This reveals an R1 situation caudally in the area of the glossotonsillar groove, so that a resection and a further final marginal sample are sent for frozen section diagnosis. This is now tumor-free. The neck is first dissected, initially on the right side: a skin incision is made along the anterior edge of the sternocleidomastoid. Dissection of the platysma and creation of a cranial platysmal flap. The external jugular vein and the auricular nerve are spared. Dissection of the vascular nerve sheath while sparing the vascular nerve structures. Dissection along the omohyoid muscle to the hyoid bone and along the digastric muscle to the laterobase. All vascular nerve structures can be preserved on the right side and levels II, III, IV and Va are removed. A lateral pharyngotomy is then performed to insert the pedicle, taking the posterior digastric venter muscle with it to prevent narrowing of the pedicle. The facial vein and the lingual vein also cross the pedicle passage so that they are ligated and cut. A lumen 2 to 3 transverse fingers in size is now created to allow the stem to pass through easily and without pressure. This is followed by the neck dissection on the left side: for this purpose, a skin incision is also made along the front edge of the sternocleidomastoid muscle in the case of two previous left cervical operations. Here, the vascular nerve sheath is dissected and the vascular nerve structures are preserved in difficult, scarred conditions. Dissection along the omohyoid muscle up to the hyoid bone and along the digastric muscle up to the laterobasis. Completion and elevation of the level II and III neck block without conspicuous lymph node pathology macroscopically. Furthermore, clearing of level Va. Macroscopically, there are no abnormal lymph nodes on the left side. However, the assessment is limited due to the scarring situation in the case of previous surgery. Parallel to the neck dissection, elevation of the radialis graft from the left forearm in tourniquet (300 mm/Hg). After measuring the graft to be lifted and marking the intended structure of the defect coverage, the lift is performed in the typical manner using a skin monitor. Skin flaps are created and subfascial preparation is made on the brachioradialis muscle. The cephalic vein is included in the elevation in order to integrate the superficial venous system into the venous drainage. Dissection distally and after using the Hayden maneuver, identification of the radial superficial ramus nerve. Protection of the nerve. Locate the vascular pedicle, cut it and further dissect the ulna. Here, too, subfascial dissection with protection of a peritendineum. Lifting now from distal to proximal into the crook of the elbow. There is no transition from the deep to the superficial venous system in the sense of a venous bridge, so that a deep vein is provided in the antecubital fossa as a connecting vein after the venae comitantes have been brought together. The cephalic vein, on the other hand, is ligated accordingly. Separation of the radial artery above the interosseous artery. The ulnar artery is clearly identified beforehand. After initial vascularization due to cold in the area of the flap, with good blood supply to the forearm and hand, after opening the tourniquet, the blood supply to the graft is regular after appropriate warming. For this reason, the graft is not lifted for half an hour to allow it to recover. This takes place completely. After careful hemostasis of minor bleeding in the area of the graft, the graft is now set down accordingly and inserted from the outside to the inside into the enoral defect for reconstruction of the soft palate and the lateral pharyngeal wall. Parts of the tongue body are sutured primarily. Incorporation leads to a successful reconstruction of the structures to be treated, followed by microvascular anastomoses. For this purpose, the superior thyroid artery is anastomosed end-to-end with the flap artery using 8/0 nylon sutures. The vein is anastomized end-to-end using a 2.5 mm vascular coupler. If the vascular flow is regular and the flap is well perfused, a fat seal is inserted into the pedicle curvature in addition to the skin monitor for better pedicle positioning. Subcutaneous sutures and skin suture on the right cervical side with insertion of a flap. On the left cervical side, the skin suture is performed in the classic sense in the form of a subcutaneous and single-button skin suture and insertion of a Redon drain. Meanwhile, the forearm is partially closed primarily and covered in the area of the lifting defect with full-thickness skin from the right groin, which was previously removed, and covered with a vacuum dressing, which should remain in place for 7 days. Application of a Cramer splint. Repositioning of the hand and forearm. Finally, creation of a tracheostoma. For this, a typical jugular skin incision is made and, after subcutaneous preparation and lateral displacement of the infrahyoid muscles, the thyroid isthmus is cut. Dissection of the anterior surface of the trachea. Creation of a caudally pedicled stoma and suturing of the stoma edge to the skin. Transfer intubation to a blockable Lanz cannula and suture the cannula. The cannula must remain in place for 5 days and any bandages and pressure in the neck area should also be avoided. The vessels are monitored by vascular Doppler examination and inspection of the skin monitor every hour for the first 72 hours and every 4 hours for a further 48 hours. If problems arise, the surgeon can be informed by telephone at any time. The patient is intubated and ventilated overnight for monitoring in the intensive care unit. \ No newline at end of file diff --git a/332/InvasionFront_CD3_block10_x3_y12_patient332_0.json b/332/InvasionFront_CD3_block10_x3_y12_patient332_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7d0b500b449821f0546769bd89322277c04a152c --- /dev/null +++ b/332/InvasionFront_CD3_block10_x3_y12_patient332_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10991.1, + "Centroid Y µm": 36003.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/332/InvasionFront_CD3_block10_x4_y12_patient332_1.json b/332/InvasionFront_CD3_block10_x4_y12_patient332_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd73ea0430e620f6c6890e48861afe2c3e56036c --- /dev/null +++ b/332/InvasionFront_CD3_block10_x4_y12_patient332_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13473.0, + "Centroid Y µm": 36560.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/332/InvasionFront_CD8_block10_x3_y12_patient332_0.json b/332/InvasionFront_CD8_block10_x3_y12_patient332_0.json new file mode 100644 index 0000000000000000000000000000000000000000..21f78c9191c1123a8f0bdd473538a43b577112be --- /dev/null +++ b/332/InvasionFront_CD8_block10_x3_y12_patient332_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12243.5, + "Centroid Y µm": 36230.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/332/InvasionFront_CD8_block10_x4_y12_patient332_1.json b/332/InvasionFront_CD8_block10_x4_y12_patient332_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ec584571a55822a9e3453565ecf0c7ede98705d9 --- /dev/null +++ b/332/InvasionFront_CD8_block10_x4_y12_patient332_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14842.1, + "Centroid Y µm": 36280.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/332/TumorCenter_CD3_block10_x3_y12_patient332_0.json b/332/TumorCenter_CD3_block10_x3_y12_patient332_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b5ab7527712e65be8212e6e13892dc5c2ea48f97 --- /dev/null +++ b/332/TumorCenter_CD3_block10_x3_y12_patient332_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.1, + "Centroid Y µm": 29035.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/332/TumorCenter_CD3_block10_x4_y12_patient332_1.json b/332/TumorCenter_CD3_block10_x4_y12_patient332_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1ffb0e26f5b52583009d78d8000ca9ea41ab4fdf --- /dev/null +++ b/332/TumorCenter_CD3_block10_x4_y12_patient332_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 28834.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/332/TumorCenter_CD8_block10_x3_y12_patient332_0.json b/332/TumorCenter_CD8_block10_x3_y12_patient332_0.json new file mode 100644 index 0000000000000000000000000000000000000000..55f365f5c744e6cc4262441bb8107f186e4e026c --- /dev/null +++ b/332/TumorCenter_CD8_block10_x3_y12_patient332_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11843.7, + "Centroid Y µm": 30134.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/332/TumorCenter_CD8_block10_x4_y12_patient332_1.json b/332/TumorCenter_CD8_block10_x4_y12_patient332_1.json new file mode 100644 index 0000000000000000000000000000000000000000..64f81161810eb74e0e53f533d47a4765df285138 --- /dev/null +++ b/332/TumorCenter_CD8_block10_x4_y12_patient332_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14392.4, + "Centroid Y µm": 30009.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/332/history_text.txt b/332/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..912322367aa17dd2a2bfdd47c9d589988dd1c73c --- /dev/null +++ b/332/history_text.txt @@ -0,0 +1 @@ +A poorly differentiated left cervical squamous cell carcinoma metastasis was histologically confirmed in the patient. The panendoscopy initially performed showed a clear support for a primary tumor. In addition to the extensive cervical lymph node metastasis, the PET-CT showed a primary, suspicious lesion in the left hypopharyngeal region, as well as an inflammatory process in the lung, but no evidence of distant metastases. Preoperatively, our pulmonology department was able to rule out active TB. In our interdisciplinary tumor conference and in a detailed discussion with the patient and relatives, the primary surgical treatment was decided. Depending on the local extent of the tumor, this may even include a laryngectomy as a last resort. \ No newline at end of file diff --git a/332/icd_codes.txt b/332/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8942df050249e3880166bd6eaf35efe4c40f2c9 --- /dev/null +++ b/332/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] \ No newline at end of file diff --git a/332/ops_codes.txt b/332/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5c43a8550e51ac23090dcaae339f0671a5faf880 --- /dev/null +++ b/332/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Biopsie am Hypopharynx ohne Inzision[1-422.1 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Transplantat[5-296.14 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.48 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/332/patient_clinical_data.json b/332/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7cbed27e22b2494e2f0540bd4ff26f4fb8956602 --- /dev/null +++ b/332/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/332/patient_pathological_data.json b/332/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6dd37114bc80e44564e6543f39c34f17e3334c71 --- /dev/null +++ b/332/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "332", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/332/surgery_description.txt b/332/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6ddf5bc6d5a961a51494666a36b472df02a9b827 --- /dev/null +++ b/332/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Radical neck dissection diff --git a/332/surgery_report.txt b/332/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..879666285b9440bacf94c084fd1bbe663c623987 --- /dev/null +++ b/332/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesia colleagues, a new pharyngo-laryngoscopy is performed to search for the primary ear again. Entry with the Kleinsasser tube under dental protection and inspection of the inconspicuous oral vestibule. Inspection of the oral cavity, which, including the floor of the mouth, tongue and soft palate, is free on inspection and palpation. Inconspicuous oropharynx on the right side. The entire hypopharynx up to the entrance to the esophagus is also clear, inconspicuous endolarynx. In the area of the left piriform sinus, an exophytic, papillomatous tumor is now visible, which grows like a lawn in the piriform sinus and almost completely fills the piriform sinus from the lateral wall to the medial side. The esophageal entrance is certainly free. It can be seen that the tumor extends laterally to the left arytenoid via the medial piriform sinus wall, as well as to the postcricoid region, but here it is superficial on all sides, with no evidence of deep infiltration. Multiple deep biopsies were taken to confirm the diagnosis. The frozen section diagnosis now shows an invasive squamous cell carcinoma matching the already confirmed lymph node metastasis. Overall, however, the flat tumor is cT3 due to its size of over 4 cm. After hemostasis using suprarenal intubation, a PEG tube was inserted. For this, insertion with the gastroscope. Under laryngoscopic control, easy advancement into the stomach. Now, with good diaphanoscopy, problem-free puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. The esophagus is inconspicuous on reflection. The patient was then repositioned and prepared for neck dissection on the left. Here a barely displaceable mass approx. 7 x 5 cm is seen, which sonographically is also clearly at least adjacent to the carotid artery. Palpation revealed clear infiltration of the sternocleidomastoid muscle. Make a curved skin incision at the anterior edge of the sternocleidomastoid muscle, taking the scar of the trial excision with it. Spindle-shaped excision of the scar. By excising the scar, the tumorous mass can be accessed directly. This is clearly a soft tissue metastasis without only a capsular structure, therefore extensive excision of the scar. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and exposure of the digastric muscle. This can just be separated from the soft tissue metastasis. Gross infiltration of the surrounding tissue. Therefore caudal separation of the sternocleidomastoid muscle, also safe infiltration of the accessorius nerve. Partial approach of the metastasis to the omohyoid muscle, which is also taken along. Detachment of the thyroid gland, which is not infiltrated. Now visualization of the internal jugular vein, which is thrombosed here and clearly infiltrated caudally. Caudal visualization of the internal jugular vein, also showing clear signs of thrombosis and a very slender vessel. Visualization of the common carotid artery and the vagus nerve. Separation of the internal jugular vein, caudal and cranial after ligation and repositioning. Exposure and release of the submandibular gland, which is exposed. Anterior exposure of the hypoglossal nerve, which is also free here, overall difficult preparation conditions. Difficult resection conditions due to the partly diffusely growing soft tissue metastasis. Now dissect the common carotid artery, which is free. Exposure of the bulb, exposure of the exit of the internal and external carotid artery. After the exit of the external carotid artery, infiltration of the superior thyroid artery is seen. Later there is also infiltration of the lingual artery. Further dissection and retrograde tracing of the hypoglossal nerve also revealed a clear infiltration of the hypoglossal nerve. This is therefore also resected. Cranially, the external carotid artery is also thickened, so that the external carotid artery is resected approx. 2 cm from the exit after puncture and multiple ligation if its exit is safely infiltrated. Now good isolation of the internal carotid artery, which can be easily released after careful dissection, no infiltration here, so that macroscopic in sano resection is performed after removal of the metastasis from level 5 with partial infiltration of the cervical plexus and the surrounding musculature. When the right side wall of the pharynx is removed, a spontaneous perforation occurs in the direction of the pharynx with direct contact to the primaries, so it can be assumed that the metastasis is growing per continuitatem. Finally, clearing of levels Va and Vb. Ligation of the caudal level Vb without evidence of lymph flow. The jugular vein had already been removed previously, but its drainage area was preserved. Now turn to tumor resection. First, after dissection of the paralaryngeal muscles, expose the thyroid cartilage horn, push off the perichondrium, remove the lateral thyroid cartilage, carefully detach the hypoharyngeal mucosa. Now enter above the spontaneous pharyngeal opening, widen the pharyngotomy. Now a good overview. As described above, the tumor appears like a turf and very superficial in the extensions. Macroscopically inconspicuous. Therefore, first resection of the macroscopically altered tissue. The resection extends over the entire piriform sinus up to the arytenoid as well as approx. 1/3 of the postcricoid region. Starting from the left arytenoid, it can be seen that a tumor turf also extends to the aryepiglottic fold and reaches up to the edge of the pharyngoepiglottic fold, completely detaching the altered area. Due to the already spontaneous perforation of the tumor, the tumor was resected in parts, certainly no deep infiltration. Completely covering the tumor, the removal of completely imaging margin samples is now carried out. In the area of the medial piriform sinus wall, there is still margin-forming CIS with otherwise in sano resection of the invasive carcinoma. Therefore, a resection is performed first and then a final margin sample is taken, which shows moderate dysplasia in the frozen section diagnosis without evidence of CIS or invasive carcinoma. Therefore, an R0 resection can be assumed here. This results in a defect that includes the entire piriform sinus, including the medial wall up to the postcricoid region. The endolarynx and the arytenoid joint itself were not altered. In addition, the left aryepiglottic fold was resected as well as the lateral edge of the epiglottis up to the vallecula. A total defect measuring approx. 10 x 5 cm is now measured, readaptation of previously released postcricoid mucosa. Due to the defect and the extensive cervical metastasis, there is now an indication for defect reconstruction. Therefore, the tracheotomy, right-sided neck dissection and ALT graft harvesting from the right thigh are now performed in parallel. First the tracheotomy. To do this, make a skin incision approx. 1 cm below the cricoid cartilage, cut through the skin and subcutaneous tissue. Expose and ligate both anterior jugular veins, expose the infrahyoid muscles, enter the linea alba. Exposure of the cricoid cartilage, exposure of the anterior surface of the trachea. Identification and clamping of the thyroid isthmus. Transection and puncture ligation. After exposing the anterior surface of the trachea, insertion between the 2nd and 3rd tracheal ring: creation of a broad-based Björk flap and insertion of the tracheostoma. Subsequent intubation, initially onto a Woodbridge tube, later onto an 8 mm Rügheimer cannula, which is suture-fixed. Now for neck dissection of the right side of the neck. To do this, make a curved skin incision on the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure of the sternocleidomastoid muscle, omohyoid muscle and digastric muscle. Exposure of the submandibular gland, exposure of the accessorius nerve and free dissection of the internal jugular vein with careful protection and the strong anterior branches of the veins, which end in a type of facial venous plexus. Exposure and preservation of the hypoglossal nerve, cervical artery and superior thyroid artery. Clearing of the accessorius triangle and level 5 with careful protection of the cervical plexus branches. Subsequent vessel preparation. An antero-lateral transfemoral graft is then harvested from the right side; after marking the landmarks, two strong main perforators and a secondary perforator are identified by Doppler sonography. Removal of a 16 x 5 cm graft to obtain a skin monitor. Initial medial skin incision, cutting through skin and subcutaneous tissue. Expose and secure the rectus femoris muscle. Strictly subfascial preparation, identification of the ramus descendens, the lateral circumflex artery. After visualization of the anatomy, it is now apparent that the ramus descendens provides an intramuscular perforator and the ramus obliquus a fasciocutaneous perforator. Careful dissection of both pedicle vessels. Despite dissection up to the groin, there is no common arterial confluence. Therefore, initially leave both vessel preparations and primarily the ramus descendens completely cut around the graft, distal ligation of the vascular pedicle. Inclusion of the fascia lata, caudal fasciocutaneous elevation of the graft in the area of the caudal perforator. Inclusion of a muscle cuff to protect the perforators. Cranial fasciocutaneous elevation again. A regular flap vitality can be seen on all sides. Now, with a long but slender vessel of the descending branch, the cranial perforator is clamped off, and even after waiting there is no change in perfusion and therefore restriction to the caudal main perforator. Dissection of the long artery and the vein after confluence and removal of the graft with normal vitality. Careful wound inspection and, if conditions are dry, insertion of a Redon drain and careful and strong two-layer wound closure. The graft is now inserted and a patch measuring approx. 10 x 5 cm is inserted into the pharyngeal defect. Overall good fit. Deepithelialization of the remaining graft, leaving an area of skin measuring approx. 3 x 3 cm in the tip of the flap. This is later sutured into the cervical skin for monitoring. After complete and sufficient suturing, there is now no possibility of left-sided anastomosis due to the narrow vessels, therefore prelaryngeal tunneling, creation of a wide tunnel of approx. 6 cm. After fixation of the fascia lata and the muscle cuff, the vessels are moved to the right side of the neck under tension-free conditions. Good positioning here. Conditioning of the flap vessels, conditioning of the superior thyroid artery, placement of the superior thyroid artery after clipping of the part. Good flow conditions here and subsequent performance of the vascular anastomosis with 8.0 Ethilon, this succeeds without any problems despite a clear caliber advantage on the part of the superior thyroid artery, followed immediately by good venous return. Conditioning of an anterior internal jugular vein, measurement of a size 3.5 coupler, problem-free performance of the venous anastomosis with the coupler, immediate regular flow with good flap perfusion. Careful positioning of the stalk and, if flap vitality is normal, cervical insertion of a 10-gauge Redon drain and careful two-layer wound closure on the left side using the raised skin monitor. Final laryngoscopic check. The graft is intact with normal vitality as far as can be assessed here. Regular vitality in the area of the skin monitor and termination of the procedure at this point. Note: Due to an intraoperative drop in oxygen saturation, the recovery process was monitored in the operating theater. A detailed clinical, neurological diagnosis reveals an oriented and responsive patient with lateral motor function and reflexes as well as lateral pupils with regular light reflexes. Postoperative neurological monitoring of the patient and, if neurological deficits occur, neurological consultation with imaging. Conclusion: Intraoperative R0 resected cT3 cN3 G3 hypopharyngeal carcinoma on the left. The defect was reconstructed using an anterolateral transfemoral graft from the right with right cervical vascular anastomosis. Please monitor the flap via the sutured skin island and via enoral inspection with the patient awake. If possible, please leave the tracheal cannula in place for at least 5-7 days postoperatively due to the prelaryngeal vascular pedicle and leave the Redon drains in place for at least 3-4 days postoperatively. If flap vitality is normal, perform an X-ray pre-swallow on the 10th postoperative day. Due to the extent of the resection, a prolonged recovery of swallowing function can be expected. \ No newline at end of file diff --git a/333/InvasionFront_CD3_block20_x5_y7_patient333_0.json b/333/InvasionFront_CD3_block20_x5_y7_patient333_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0ab523dd6592b0df4c9f92cbe7770e48b4879f16 --- /dev/null +++ b/333/InvasionFront_CD3_block20_x5_y7_patient333_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17091.0, + "Centroid Y µm": 17790.6, + "Num Detections": 21521, + "Num Negative": 19125, + "Num Positive": 2396, + "Positive %": 11.13, + "Num Positive per mm^2": 968.59 + } +} \ No newline at end of file diff --git a/333/InvasionFront_CD3_block20_x6_y7_patient333_1.json b/333/InvasionFront_CD3_block20_x6_y7_patient333_1.json new file mode 100644 index 0000000000000000000000000000000000000000..634d7a0c0c2c73c0be0c20b4cf37a0d7b0d1f5aa --- /dev/null +++ b/333/InvasionFront_CD3_block20_x6_y7_patient333_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19639.6, + "Centroid Y µm": 18190.4, + "Num Detections": 21738, + "Num Negative": 20716, + "Num Positive": 1022, + "Positive %": 4.701, + "Num Positive per mm^2": 405.36 + } +} \ No newline at end of file diff --git a/333/InvasionFront_CD8_block20_x5_y7_patient333_0.json b/333/InvasionFront_CD8_block20_x5_y7_patient333_0.json new file mode 100644 index 0000000000000000000000000000000000000000..36d2c5625fca8513b3bdaea8088a0062d24f7ac1 --- /dev/null +++ b/333/InvasionFront_CD8_block20_x5_y7_patient333_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 17515.7, + "Num Detections": 22399, + "Num Negative": 21467, + "Num Positive": 932, + "Positive %": 4.161, + "Num Positive per mm^2": 383.99 + } +} \ No newline at end of file diff --git a/333/InvasionFront_CD8_block20_x6_y7_patient333_1.json b/333/InvasionFront_CD8_block20_x6_y7_patient333_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f4c74d84b1d260c45fe779d3be6a766bfbdf113 --- /dev/null +++ b/333/InvasionFront_CD8_block20_x6_y7_patient333_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19589.6, + "Centroid Y µm": 17540.7, + "Num Detections": 21322, + "Num Negative": 21109, + "Num Positive": 213, + "Positive %": 0.999, + "Num Positive per mm^2": 85.54 + } +} \ No newline at end of file diff --git a/333/TumorCenter_CD3_block20_x5_y7_patient333_0.json b/333/TumorCenter_CD3_block20_x5_y7_patient333_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08dece9e1cb92d041f994bd412145282fa1cce56 --- /dev/null +++ b/333/TumorCenter_CD3_block20_x5_y7_patient333_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16226.2, + "Centroid Y µm": 16724.8, + "Num Detections": 12252, + "Num Negative": 11869, + "Num Positive": 383, + "Positive %": 3.126, + "Num Positive per mm^2": 161.79 + } +} \ No newline at end of file diff --git a/333/TumorCenter_CD3_block20_x6_y7_patient333_1.json b/333/TumorCenter_CD3_block20_x6_y7_patient333_1.json new file mode 100644 index 0000000000000000000000000000000000000000..da41dbb714597536ce4f00ffa12caeac4c46da46 --- /dev/null +++ b/333/TumorCenter_CD3_block20_x6_y7_patient333_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18838.3, + "Centroid Y µm": 16845.1, + "Num Detections": 18900, + "Num Negative": 17976, + "Num Positive": 924, + "Positive %": 4.889, + "Num Positive per mm^2": 394.36 + } +} \ No newline at end of file diff --git a/333/TumorCenter_CD8_block20_x5_y7_patient333_0.json b/333/TumorCenter_CD8_block20_x5_y7_patient333_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a219dd61004933f3ee8ed5f40b7def53db068f33 --- /dev/null +++ b/333/TumorCenter_CD8_block20_x5_y7_patient333_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16116.5, + "Centroid Y µm": 17240.9, + "Num Detections": 21264, + "Num Negative": 20929, + "Num Positive": 335, + "Positive %": 1.575, + "Num Positive per mm^2": 132.27 + } +} \ No newline at end of file diff --git a/333/TumorCenter_CD8_block20_x6_y7_patient333_1.json b/333/TumorCenter_CD8_block20_x6_y7_patient333_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9baa849a192ecbdd82c7a026e261d485228a9f3f --- /dev/null +++ b/333/TumorCenter_CD8_block20_x6_y7_patient333_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 17190.9, + "Num Detections": 16973, + "Num Negative": 16270, + "Num Positive": 703, + "Positive %": 4.142, + "Num Positive per mm^2": 347.69 + } +} \ No newline at end of file diff --git a/333/history_text.txt b/333/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/333/icd_codes.txt b/333/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1bc865abf12998d031d42aafb5c2257f9db7a99b --- /dev/null +++ b/333/icd_codes.txt @@ -0,0 +1 @@ +Karzinom aryepiglottische Falte hypopharyngeale Seite[C13.1 R] \ No newline at end of file diff --git a/333/ops_codes.txt b/333/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6d4bd0e1164908d8fe92bceeedd434dea35768de --- /dev/null +++ b/333/ops_codes.txt @@ -0,0 +1 @@ +Selektive Neck dissection in 3 Regionen[5-403.02 B] Sonstige diagnostische Pharyngoskopie[1-611.x ] PEG-Sonde Anlage[5-431.2 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] Laserresektion Larynxgewebe mit Stützlaryngoskopie[5-302.5 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] \ No newline at end of file diff --git a/333/patient_clinical_data.json b/333/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..159b9ee17cbbc4b3c001de99f91e9b55e3aa4f32 --- /dev/null +++ b/333/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 40, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/333/patient_pathological_data.json b/333/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0ae82e618754e8eb2d4dc4ec1d68032fb5c13e3a --- /dev/null +++ b/333/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "333", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/333/surgery_description.txt b/333/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b60d901be9796808ce6ff562302f907a8592e1d --- /dev/null +++ b/333/surgery_description.txt @@ -0,0 +1 @@ +Transoral laser resection, Functional neck dissection diff --git a/333/surgery_report.txt b/333/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..639eb241ed51c1ba1fa466e66c9b6c19739919b7 --- /dev/null +++ b/333/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation with the laser tube by the anesthetist. Then, first of all, entry with the Kleinsasser tube and inspection of the hypopharynx and larynx area. The hypopharynx including the piriform sinus is unremarkable. The tumor is located on the laryngeal surface of the epiglottis, extends downwards at the edge of the right vallecula and merges with the aryepiglottic fold. However, the ary on the right is not affected by the tumor. The base of the tongue is also not affected by the tumor. Insertion of a spreading laryngoscope and preliminary shaping of the laser and with the microscope. Then demonstration of the findings on and also briefly on . It is recommended to divide the epiglottis and remove the tumor successively with the laser. The epiglottis is then also divided first. The tumor is surrounded by the laser along its borders with a safety margin of approx. 1 cm. The preparation is then marked with a thread for the frozen section. At two points where the tumor appeared very close to the healthy tissue macroscopically, marginal samples are taken. These margin samples are also tumor-free in the frozen section. Unfortunately, there are still tumor cells in the frozen section in the area of the transition from the vallecula to the pharyngeal side wall, so a large resection is taken there and then another marginal sample, the last marginal sample is then tumor-free. Due to the size of the defect, a tracheotomy is performed in the usual manner. This involves a skin incision, then dissection down to the musculature. Push the muscles aside, expose the thyroid gland, cut through the thyroid isthmus. Exposing the trachea and entering the trachea between the 1st and 2nd tracheal cartilage. Creation of a visor tracheotomy. Omission of a Björk flap. Creation of a mucocutaneous anastomosis and reintubation to an 8 mm tracheal cannula. Neck dissection on the left (/): Skin incision on the anterior border of the sternocleidomastoid muscle, exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle. Visualization of the submandibular gland, visualization of the posterior belly of the digaster muscle. Exposure of the cervical vascular sheath. Dissection of the internal jugular vein. Exposure of the accessorius nerve, clearing of levels IIa, III and IV while preserving all structures. Then neck dissection on the right side (/): Similar procedure in principle, skin incision on the anterior border of the sternocleidomatoid muscle, exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the posterior digastric muscle. Exposure of the cervical vascular sheath, free dissection of the internal jugular vein, exposure of the accessorius nerve. Evacuation of levels IIa, III, IV and Va while sparing the plexus branches. PEG insertion: very careful insertion with the flexible esophagoscope, as the patient has esophageal varices I°. This is also successful without any problems. The stomach shows a cobblestone-like relief in the sense of erosive gastritis. Diaphanoscopy is good and the PEG is inserted in the usual manner using the thread pull-through method. Please continue antibiotics for 3 days. The patient is admitted to the intensive care unit, but may wake up. The PEG should not be loosened until the 3rd postoperative day. Wait for histology and presentation of the patient at the tumor conference. \ No newline at end of file diff --git a/334/InvasionFront_CD3_block1_x5_y6_patient334_0.json b/334/InvasionFront_CD3_block1_x5_y6_patient334_0.json new file mode 100644 index 0000000000000000000000000000000000000000..deafe3acf789a30e1e8ac17aabcc0c41b3270f72 --- /dev/null +++ b/334/InvasionFront_CD3_block1_x5_y6_patient334_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 17041.0, + "Num Detections": 13377, + "Num Negative": 13180, + "Num Positive": 197, + "Positive %": 1.473, + "Num Positive per mm^2": 130.63 + } +} \ No newline at end of file diff --git a/334/InvasionFront_CD3_block1_x6_y6_patient334_1.json b/334/InvasionFront_CD3_block1_x6_y6_patient334_1.json new file mode 100644 index 0000000000000000000000000000000000000000..85fa8178ef3cde2ac8342d94e9f210cd51e8e434 --- /dev/null +++ b/334/InvasionFront_CD3_block1_x6_y6_patient334_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 17215.9, + "Num Detections": 11497, + "Num Negative": 11358, + "Num Positive": 139, + "Positive %": 1.209, + "Num Positive per mm^2": 104.29 + } +} \ No newline at end of file diff --git a/334/InvasionFront_CD8_block1_x5_y6_patient334_0.json b/334/InvasionFront_CD8_block1_x5_y6_patient334_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b3de956037dde79c480039eb00f80a719484cfab --- /dev/null +++ b/334/InvasionFront_CD8_block1_x5_y6_patient334_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16691.2, + "Centroid Y µm": 15766.7, + "Num Detections": 11930, + "Num Negative": 11785, + "Num Positive": 145, + "Positive %": 1.215, + "Num Positive per mm^2": 108.57 + } +} \ No newline at end of file diff --git a/334/InvasionFront_CD8_block1_x6_y6_patient334_1.json b/334/InvasionFront_CD8_block1_x6_y6_patient334_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7648302fe7f2401e562c0c16e31c1ff07f81bc56 --- /dev/null +++ b/334/InvasionFront_CD8_block1_x6_y6_patient334_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 15891.6, + "Num Detections": 13227, + "Num Negative": 13144, + "Num Positive": 83, + "Positive %": 0.6275, + "Num Positive per mm^2": 60.76 + } +} \ No newline at end of file diff --git a/334/TumorCenter_CD3_block1_x5_y8_patient334_0.json b/334/TumorCenter_CD3_block1_x5_y8_patient334_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d2689114c1b9750bfdc420d627ccbfc374a4a4fa --- /dev/null +++ b/334/TumorCenter_CD3_block1_x5_y8_patient334_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 19889.5, + "Num Detections": 23747, + "Num Negative": 10698, + "Num Positive": 13049, + "Positive %": 54.95, + "Num Positive per mm^2": 5361.8 + } +} \ No newline at end of file diff --git a/334/TumorCenter_CD3_block1_x6_y8_patient334_1.json b/334/TumorCenter_CD3_block1_x6_y8_patient334_1.json new file mode 100644 index 0000000000000000000000000000000000000000..850e22dd28b333c8d23dd5ec5b02567b258ba795 --- /dev/null +++ b/334/TumorCenter_CD3_block1_x6_y8_patient334_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 19864.5, + "Num Detections": 23509, + "Num Negative": 13694, + "Num Positive": 9815, + "Positive %": 41.75, + "Num Positive per mm^2": 3911.2 + } +} \ No newline at end of file diff --git a/334/TumorCenter_CD8_block1_x5_y6_patient334_0.json b/334/TumorCenter_CD8_block1_x5_y6_patient334_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c04265325856d5999f278da34ebb6868e3e349fd --- /dev/null +++ b/334/TumorCenter_CD8_block1_x5_y6_patient334_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 23737.4, + "Num Detections": 18329, + "Num Negative": 17938, + "Num Positive": 391, + "Positive %": 2.133, + "Num Positive per mm^2": 176.5 + } +} \ No newline at end of file diff --git a/334/TumorCenter_CD8_block1_x6_y6_patient334_1.json b/334/TumorCenter_CD8_block1_x6_y6_patient334_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf223e8b460d3308786487e4d1094d9b2a75fa6c --- /dev/null +++ b/334/TumorCenter_CD8_block1_x6_y6_patient334_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21363.7, + "Centroid Y µm": 23487.6, + "Num Detections": 16433, + "Num Negative": 16311, + "Num Positive": 122, + "Positive %": 0.7424, + "Num Positive per mm^2": 61.68 + } +} \ No newline at end of file diff --git a/334/history_text.txt b/334/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c0096ea2f93bcb6317947a5de67ed9a3632d2c4 --- /dev/null +++ b/334/history_text.txt @@ -0,0 +1 @@ +The patient has a condition after primary RCT of a hypopharyngeal carcinoma in 2008, a condition after bronchial carcinoma in 2013, a condition after gastric carcinoma in 2010 and now a third carcinoma in the area of the vallecula. There are no more radiotherapeutic options. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/334/icd_codes.txt b/334/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7057fa5b52c6cb466319a8d113d464e13dd0ff79 --- /dev/null +++ b/334/icd_codes.txt @@ -0,0 +1 @@ +2. Term. Bösartige Neubildung: Kolon, mehrere Teilbereiche überlappend[C18.8 ] Karzinom der Vallecula epiglottica[C10.0 ] \ No newline at end of file diff --git a/334/ops_codes.txt b/334/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..61ee97a1a4a81b3c2d6aadf6aa4c09f23b793ecf --- /dev/null +++ b/334/ops_codes.txt @@ -0,0 +1 @@ +Laserkoagulation Pharynxgewebe[5-292.31 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Epiglottektomie durch Stützlaryngoskopie[5-302.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/334/patient_clinical_data.json b/334/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5a3a5d2bd236a8d3d803d95ea91c658445774e2d --- /dev/null +++ b/334/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/334/patient_pathological_data.json b/334/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ca88308ff8b89b78e6fe6c14557555e368281252 --- /dev/null +++ b/334/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "334", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/334/surgery_description.txt b/334/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ea86abf2f0cf0d4ff5cb414d6672f86fbfddb13f --- /dev/null +++ b/334/surgery_description.txt @@ -0,0 +1 @@ +Transoral laser resection, Tracheotomy diff --git a/334/surgery_report.txt b/334/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2f760f311e5c3cb1ad5ac24919de35049fdf7ae8 --- /dev/null +++ b/334/surgery_report.txt @@ -0,0 +1 @@ +Dictation : Induction of anesthesia and intubation using a laser tube via the anesthesia. Entry with the Kleinsasser tube and inspection of the site. A flat exophytic mass is seen in the area of the vallecula with transition to the base of the tongue and the lingual surface of the epiglottis. Now insertion of the spreading laryngoscope and advance of the microscope including laser. Start with laser resection 4 watt continuous wave superpulse on the left side in the area of the base of the tongue. Then successive laser resection in the area of the base of the tongue down to the hyoid bone. Removal of the epiglottis in the lateral area on both sides. The epiglottis itself cannot be retained due to the tumor infiltration. The resection of the epiglottis was discussed in advance with , who also demonstrated the findings. The specimen is placed on cork for final histology. Then several marginal samples are taken. The marginal samples are all tumor-free in the frozen section. The decision is then made to perform a tracheostomy for functional reasons, as aspiration is to be expected. The tracheostomy was performed by . Hemostasis was performed using monopolar coagulation and vascular clips. Dictation : Now creation of a protective tracheostomy. Head reclination. Infiltration with local anesthetic Ultracaine 2% with Suprarenin added under the palpable cricoid cartilage with a total of 10 ml. Skin disinfection and sterile draping. Mark the landmarks and the level of the cricoid cartilage. One transverse finger below, mark the skin incision according to Kocher and cut through the skin and subcutaneous tissue. Dissect down to the linea alba and enter it. Separation of the infrahyoid musculature and exposure of the small, sparse thyroid gland. Overall, hardened and fibrotic conditions after radiotherapy. Undermining of the thyroid gland and placement of the Pean clamps on the right and left. Cutting of the thyroid isthmus. Stitching of the thyroid gland on the right and left, after placement of the blocker and good view of the anterior tracheal surface. Prior to this, the cricoid cartilage was dissected, which was easily palpable. The trachea was then opened between the second and third tracheal cartilage clasps and then epithelialized, after undermining the skin to create a tension-free mucocutaneous anastomosis as a visor tracheotomy. A total of four sutures caudally and four sutures cranially. Problem-free reintubation to a 9 mm tracheostomy tube. \ No newline at end of file diff --git a/335/InvasionFront_CD3_block20_x1_y9_patient335_0.json b/335/InvasionFront_CD3_block20_x1_y9_patient335_0.json new file mode 100644 index 0000000000000000000000000000000000000000..06c497aea04f8d661da94b9af93a7a60f1063b82 --- /dev/null +++ b/335/InvasionFront_CD3_block20_x1_y9_patient335_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4363.5, + "Centroid Y µm": 21538.6, + "Num Detections": 13746, + "Num Negative": 11333, + "Num Positive": 2413, + "Positive %": 17.55, + "Num Positive per mm^2": 1353.1 + } +} \ No newline at end of file diff --git a/335/InvasionFront_CD3_block20_x2_y9_patient335_1.json b/335/InvasionFront_CD3_block20_x2_y9_patient335_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69fbc76a61478fd66494c8f3593ba9e006b8c1b5 --- /dev/null +++ b/335/InvasionFront_CD3_block20_x2_y9_patient335_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6433.1, + "Centroid Y µm": 21763.5, + "Num Detections": 13643, + "Num Negative": 11412, + "Num Positive": 2231, + "Positive %": 16.35, + "Num Positive per mm^2": 1275.7 + } +} \ No newline at end of file diff --git a/335/InvasionFront_CD8_block20_x1_y9_patient335_0.json b/335/InvasionFront_CD8_block20_x1_y9_patient335_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2efb4dfecfa95f8726ad106d4edc9f948d017daf --- /dev/null +++ b/335/InvasionFront_CD8_block20_x1_y9_patient335_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4898.5, + "Centroid Y µm": 22870.8, + "Num Detections": 14983, + "Num Negative": 9988, + "Num Positive": 4995, + "Positive %": 33.34, + "Num Positive per mm^2": 2733.3 + } +} \ No newline at end of file diff --git a/335/InvasionFront_CD8_block20_x2_y9_patient335_1.json b/335/InvasionFront_CD8_block20_x2_y9_patient335_1.json new file mode 100644 index 0000000000000000000000000000000000000000..506b24fd9ece67b3994e018bc08c0096995b9aa1 --- /dev/null +++ b/335/InvasionFront_CD8_block20_x2_y9_patient335_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6955.9, + "Centroid Y µm": 22853.5, + "Num Detections": 13404, + "Num Negative": 10828, + "Num Positive": 2576, + "Positive %": 19.22, + "Num Positive per mm^2": 1445.3 + } +} \ No newline at end of file diff --git a/335/TumorCenter_CD3_block20_x1_y9_patient335_0.json b/335/TumorCenter_CD3_block20_x1_y9_patient335_0.json new file mode 100644 index 0000000000000000000000000000000000000000..afa96af4620f57b8a0c6c8c5c29f7cbeda97e517 --- /dev/null +++ b/335/TumorCenter_CD3_block20_x1_y9_patient335_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3662.3, + "Centroid Y µm": 21587.7, + "Num Detections": 9263, + "Num Negative": 5302, + "Num Positive": 3961, + "Positive %": 42.76, + "Num Positive per mm^2": 2224.8 + } +} \ No newline at end of file diff --git a/335/TumorCenter_CD3_block20_x2_y9_patient335_1.json b/335/TumorCenter_CD3_block20_x2_y9_patient335_1.json new file mode 100644 index 0000000000000000000000000000000000000000..370ae587d9ded6b9b2ece6318e6b006f14041ad0 --- /dev/null +++ b/335/TumorCenter_CD3_block20_x2_y9_patient335_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6245.0, + "Centroid Y µm": 21628.1, + "Num Detections": 8204, + "Num Negative": 4736, + "Num Positive": 3468, + "Positive %": 42.27, + "Num Positive per mm^2": 2271.3 + } +} \ No newline at end of file diff --git a/335/TumorCenter_CD8_block20_x1_y9_patient335_0.json b/335/TumorCenter_CD8_block20_x1_y9_patient335_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f764eaf4dba5e048b35af34ef679ad200c979699 --- /dev/null +++ b/335/TumorCenter_CD8_block20_x1_y9_patient335_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3823.0, + "Centroid Y µm": 22962.8, + "Num Detections": 12212, + "Num Negative": 5631, + "Num Positive": 6581, + "Positive %": 53.89, + "Num Positive per mm^2": 3713.0 + } +} \ No newline at end of file diff --git a/335/TumorCenter_CD8_block20_x2_y9_patient335_1.json b/335/TumorCenter_CD8_block20_x2_y9_patient335_1.json new file mode 100644 index 0000000000000000000000000000000000000000..627cf5b263f3bf34e15747a192f9e11895e555d9 --- /dev/null +++ b/335/TumorCenter_CD8_block20_x2_y9_patient335_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 22738.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/335/history_text.txt b/335/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ff8ce3b27767ae4723019cebc83b7673435a0fb --- /dev/null +++ b/335/history_text.txt @@ -0,0 +1 @@ +The patient presented to the emergency department due to shortness of breath and underwent a tracheostomy and panendoscopy that same evening in LA. A sample was taken which revealed squamous cell carcinoma. \ No newline at end of file diff --git a/335/icd_codes.txt b/335/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..30353acafcd35be15dde935affccf8de4bbeec48 --- /dev/null +++ b/335/icd_codes.txt @@ -0,0 +1 @@ +Larynxkarzinom[C32.9 ] Sonstige follikuläre Zyste Haut und Unterhaut[L72.8 L] \ No newline at end of file diff --git a/335/ops_codes.txt b/335/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..db1d741ea43c6d36ff075a1314edcea049635c4b --- /dev/null +++ b/335/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Offene pharyngozervikale Ösophagomyotomie[5-420.11 ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Atheromexstirpation und Wundverschluss Schulter und Axilla[5-894.16 L] \ No newline at end of file diff --git a/335/patient_clinical_data.json b/335/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1a1c0296d2ca12acd34612a5015b44ce812693ad --- /dev/null +++ b/335/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 45, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/335/patient_pathological_data.json b/335/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..315bf6fb9aedd13bb0e6d4bbbed1b11dc3ebc648 --- /dev/null +++ b/335/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "335", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 61, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/335/surgery_description.txt b/335/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5039d2ac181700ed13ffb1191a3dab1b78849a59 --- /dev/null +++ b/335/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection (Level II - Va), Provox, Endoscopy diff --git a/335/surgery_report.txt b/335/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..defd33c5391338318e4b196befc1b3eddc29c9bd --- /dev/null +++ b/335/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthetist. Entry with the small bore tube and inspection of the hypopharyngeal and laryngeal areas. This is extremely difficult as the patient is almost impossible to adjust. The epiglottis and the piriform sinus and postcricoid region can be visualized with difficulty. The tumor itself is barely visible and is located on the right in the area of the aryepiglottic fold. Further adjustment is not possible, not even after 3-fold relaxation. Insertion of a nasogastric tube and injection of xylocaine/adrenaline mixture in the neck, then sterile washing and draping. Now form an apron flap in the usual manner. Start on the right side with dissection of the sternocleidomastoid muscle and the cervical vascular sheath. Detach the cervical vascular sheath from the larynx area. Then switch to the opposite side. Here too, detachment of the cervical vascular sheath and the sternocleidomastoid muscle from the larynx. Exposure of the omohyoid muscle on both sides. Exposure of the hyoid bone and detachment of the hyoid bone from the base of the tongue, as the hyoid bone is to be integrated into the laryngeal preparation. Visualization of the thyroid gland on both sides and detachment of the thyroid gland from the trachea and larynx. Detachment of the upper horn of the thyroid cartilage, initially on the left side by severing the constrictor pharyngis muscle. Detachment of the piriform sinus with the freer from the thyroid cartilage. Switch to the right side and also detach the constrictor pharyngis muscle from the thyroid cartilage and the upper horn of the thyroid cartilage. Then release the piriform sinus with the freer. Now enter the mouth with a TE spatula and elevate the base of the tongue. Then enter the pharynx directly above the hyoid bone. Create a small pharyngotomy. Pull out the epiglottis and release the pharyngeal mucosa and laryngeal preparation along the lateral edges of the epiglottis. This is done carefully up to the postcricoid region. The tumor is now completely visible. The tumor encompasses the aryepiglottic fold, the petiolus and then extends into the glottis. A lot of mucosa can be spared postcricoidally and in the area of the piriform sinus. Deposit the laryngeal preparation directly below the cricoid cartilage. Removal of marginal samples in the pharyngeal region. These are all tumor-free. The difficulty now arises that the patient has already had a tracheostomy and this tracheostomy was also very deep, so the entire tracheostoma, including the torn-out sections, must be completely revised. The granulation tissue must be removed and a lot of skin mobilized to create a mucocutaneous anastomosis. Then perform an anterolateral myotomy by and insert the Provox prosthesis 0.5 cm below the upper edge of the trachea on the posterior wall of the trachea in the usual manner. Pass the pharyngeal suture through , initially using inverting single button sutures starting from caudal to cranial. So much mucosa is preserved in the area of the base of the tongue that the mucosa can be adapted without forming a "T". Then place a 2nd, now continuous pharyngeal suture over it. Then adaptation of the thyroid gland so that it does not deepen the tracheostoma crater. Before the pharyngeal suture, a myotomy of the sternocleidomastoid muscle was performed on both sides by . Wound irrigation and hemostasis using bipolar coagulation. Insertion of two 10-gauge Redon drains and two-layer wound closure with completion of the tracheostoma. Finally, the atheroma on the left axilla area is removed. Spindle-shaped incision and dissection in the subcutaneous area, then two-layer wound closure. Multiple intraoperative demonstrations on . The patient is ventilated in the intensive care unit and can wake up the following day. Please continue the intravenous antibiotics for 3 days, after 10 days an X-ray gruel swallow and if no fistula is found, diet build-up. After receiving the histology, the patient is presented at the tumor conference. \ No newline at end of file diff --git a/336/InvasionFront_CD3_block14_x3_y9_patient336_0.json b/336/InvasionFront_CD3_block14_x3_y9_patient336_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3fe211ba0801ccdfe322194b4469339801671a55 --- /dev/null +++ b/336/InvasionFront_CD3_block14_x3_y9_patient336_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11543.9, + "Centroid Y µm": 26361.0, + "Num Detections": 20801, + "Num Negative": 16825, + "Num Positive": 3976, + "Positive %": 19.11, + "Num Positive per mm^2": 1662.0 + } +} \ No newline at end of file diff --git a/336/InvasionFront_CD3_block14_x4_y9_patient336_1.json b/336/InvasionFront_CD3_block14_x4_y9_patient336_1.json new file mode 100644 index 0000000000000000000000000000000000000000..57fa9f70daca3ddf434cb4f3edb6f284ee59d531 --- /dev/null +++ b/336/InvasionFront_CD3_block14_x4_y9_patient336_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14192.5, + "Centroid Y µm": 26436.0, + "Num Detections": 17723, + "Num Negative": 14563, + "Num Positive": 3160, + "Positive %": 17.83, + "Num Positive per mm^2": 1509.2 + } +} \ No newline at end of file diff --git a/336/InvasionFront_CD8_block14_x3_y9_patient336_0.json b/336/InvasionFront_CD8_block14_x3_y9_patient336_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3271280f3ef75d73450b102fd51cca8a33d9938f --- /dev/null +++ b/336/InvasionFront_CD8_block14_x3_y9_patient336_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11743.8, + "Centroid Y µm": 21988.4, + "Num Detections": 20037, + "Num Negative": 16652, + "Num Positive": 3385, + "Positive %": 16.89, + "Num Positive per mm^2": 1450.8 + } +} \ No newline at end of file diff --git a/336/InvasionFront_CD8_block14_x4_y9_patient336_1.json b/336/InvasionFront_CD8_block14_x4_y9_patient336_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c2be8325127ef16245eb2c51e470b53c52978d5 --- /dev/null +++ b/336/InvasionFront_CD8_block14_x4_y9_patient336_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 22063.3, + "Num Detections": 21186, + "Num Negative": 16113, + "Num Positive": 5073, + "Positive %": 23.95, + "Num Positive per mm^2": 2099.0 + } +} \ No newline at end of file diff --git a/336/TumorCenter_CD3_block14_x3_y9_patient336_0.json b/336/TumorCenter_CD3_block14_x3_y9_patient336_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a9cffb5514fda6f641f520ec4363090d552e73a5 --- /dev/null +++ b/336/TumorCenter_CD3_block14_x3_y9_patient336_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 22837.9, + "Num Detections": 19825, + "Num Negative": 13417, + "Num Positive": 6408, + "Positive %": 32.32, + "Num Positive per mm^2": 2674.4 + } +} \ No newline at end of file diff --git a/336/TumorCenter_CD3_block14_x4_y9_patient336_1.json b/336/TumorCenter_CD3_block14_x4_y9_patient336_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1cc1eea361de4bfff654a1f27058e57d4acb46a0 --- /dev/null +++ b/336/TumorCenter_CD3_block14_x4_y9_patient336_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 22962.8, + "Num Detections": 19728, + "Num Negative": 13870, + "Num Positive": 5858, + "Positive %": 29.69, + "Num Positive per mm^2": 2464.7 + } +} \ No newline at end of file diff --git a/336/TumorCenter_CD8_block14_x3_y9_patient336_0.json b/336/TumorCenter_CD8_block14_x3_y9_patient336_0.json new file mode 100644 index 0000000000000000000000000000000000000000..840a0eac271d397ad017f202eef1d55466c014b2 --- /dev/null +++ b/336/TumorCenter_CD8_block14_x3_y9_patient336_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10644.4, + "Centroid Y µm": 22987.8, + "Num Detections": 19327, + "Num Negative": 13168, + "Num Positive": 6159, + "Positive %": 31.87, + "Num Positive per mm^2": 2575.8 + } +} \ No newline at end of file diff --git a/336/TumorCenter_CD8_block14_x4_y9_patient336_1.json b/336/TumorCenter_CD8_block14_x4_y9_patient336_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8565ac9b57ffeb965492310e611f9832f0f19872 --- /dev/null +++ b/336/TumorCenter_CD8_block14_x4_y9_patient336_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13143.0, + "Centroid Y µm": 23012.8, + "Num Detections": 19403, + "Num Negative": 14387, + "Num Positive": 5016, + "Positive %": 25.85, + "Num Positive per mm^2": 2124.5 + } +} \ No newline at end of file diff --git a/336/history_text.txt b/336/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/336/icd_codes.txt b/336/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/336/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/336/ops_codes.txt b/336/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3a534e4a995432e4a3dbe521a123d091ba1251a1 --- /dev/null +++ b/336/ops_codes.txt @@ -0,0 +1 @@ +Zungentumorexzision[5-250.2 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/336/patient_clinical_data.json b/336/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a2de5c3285df7b814dd36bf5c68dcf1213665be5 --- /dev/null +++ b/336/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/336/patient_pathological_data.json b/336/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..982097a9098afae2be5b0481c2b7f4d250e55e09 --- /dev/null +++ b/336/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "336", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 6.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/336/surgery_description.txt b/336/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d4ddb546845612251f637e6757da8a55d4cf97b2 --- /dev/null +++ b/336/surgery_description.txt @@ -0,0 +1 @@ +Partial tongue resection, Bilateral neck dissection diff --git a/336/surgery_report.txt b/336/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c127b54e8105096c56016b861fcf4d0f95479c02 --- /dev/null +++ b/336/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Positioning of the patient and insertion of the mouth guard. Approximation of the tongue. An exophytic mass on the edge of the tongue with a dorsal leuoplakia is revealed. This mass is first incised with the electric needle and the resection margins are determined. It can be seen that the mass is very superficial, so that the body of the tongue is only covered superficially. The resection depth reaches a maximum of around 1 cm. The resection is performed successively and extremely carefully with subtle hemostasis and ligation of some larger arterial vessels. If the wound is dry, representative samples are taken from the margins, all of which are found to be tumor-free in the frozen section. This therefore appears to be an R0 resection. The tumor specimen is sent for final histopathological assessment in thread-reinforced form. Infiltration of the tongue with a long-acting local anesthetic. The edge of the tongue is then closed with inverted sutures. After aspiration of blood residue, removal of the mouth block. Repositioning of the patient for neck dissection on both sides. Injection of local anesthetic with adrenaline cervically on both sides. Start on the right side, where numerous suspicious lumps were found on ultrasound. Incision along the sternocleidomastoid muscle on the right side. Exposure of the platysma. Dissection of the platysma and layer-by-layer dissection in depth. Exposure of the omohyoid muscle and digaster muscle. Insertion of the retractors. A large lymph node conglomerate can be seen in the venous angle. Exposure of the cervical vascular sheath and long dissection of the same. Long-distance dissection and exposure of the accessorius nerve. Performing a neurolysis and re-embedding of the accessory nerve at the end of the operation. Similarly, long dissection of the vagus nerve with displacement, neurolysis and re-embedding. Resection of the lateral neck preparation from level IIa caudally to the level of the omohyoid muscle. All branches of the internal jugular vein and external carotid artery can be spared. Clearing of the hypoglossal triangle. Long-distance dissection, relocation and re-embedding of the hypoglossal nerve in the sense of a neurolysis. Here too, all vascular and nerve structures are preserved. Removal of the level III and IV anterior neck preparation. Exposure of the capsule of the submandibular gland and palpation in level I, where no suspicious masses can be palpated. Perform subtle hemostasis. Insertion of a size 10 Redon drain and two-layer wound closure. Application of a pressure bandage. Repositioning for neck dissection on the left side. Here only sonographically enlarged, slightly suspicious nodes are visible. Here too, the incision is made along the anterior edge of the sternocleidomastoid muscle. Dissection in depth in layers and exposure of the cervical vascular sheath. This is also dissected over a long distance with long-distance exposure, displacement and re-embedding of the vagus nerve in the sense of a neurolysis. Long-distance dissection, exposure, displacement and re-embedding of the accessory nerve in the sense of a neurolysis. In the course of the same dissection of the hypoglossal nerve, presentation, displacement and re-embedding of the hypoglossal nerve in the sense of a neurolysis. Clearing of levels II and III. Several enlarged but macroscopically unsuspicious lymph nodes can be seen in the area of the accessorius triangle and venous angle. Here too, the specimen is sent for histopathological examination. After subtle hemostasis, insertion of a Redon drain. Two-layer wound closure. Application of a pressure bandage. Final consultation with the anesthetist. Completion of the procedure. Further procedure depending on the final histopathological findings. \ No newline at end of file diff --git a/337/InvasionFront_CD3_block19_x1_y8_patient337_0.json b/337/InvasionFront_CD3_block19_x1_y8_patient337_0.json new file mode 100644 index 0000000000000000000000000000000000000000..279d88a2559626f9b48954e8443157afcb852278 --- /dev/null +++ b/337/InvasionFront_CD3_block19_x1_y8_patient337_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4247.8, + "Centroid Y µm": 21763.5, + "Num Detections": 17127, + "Num Negative": 17069, + "Num Positive": 58, + "Positive %": 0.3386, + "Num Positive per mm^2": 29.24 + } +} \ No newline at end of file diff --git a/337/InvasionFront_CD3_block19_x2_y8_patient337_1.json b/337/InvasionFront_CD3_block19_x2_y8_patient337_1.json new file mode 100644 index 0000000000000000000000000000000000000000..79e5c1eb9df017bba80e97846b665651ef048fc9 --- /dev/null +++ b/337/InvasionFront_CD3_block19_x2_y8_patient337_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6871.4, + "Centroid Y µm": 21863.4, + "Num Detections": 22955, + "Num Negative": 22869, + "Num Positive": 86, + "Positive %": 0.3746, + "Num Positive per mm^2": 35.26 + } +} \ No newline at end of file diff --git a/337/InvasionFront_CD8_block19_x1_y8_patient337_0.json b/337/InvasionFront_CD8_block19_x1_y8_patient337_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f8bb57ba804ba45a0b35501c293a71420c3e96e2 --- /dev/null +++ b/337/InvasionFront_CD8_block19_x1_y8_patient337_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 29759.2, + "Num Detections": 25133, + "Num Negative": 24547, + "Num Positive": 586, + "Positive %": 2.332, + "Num Positive per mm^2": 234.25 + } +} \ No newline at end of file diff --git a/337/InvasionFront_CD8_block19_x2_y8_patient337_1.json b/337/InvasionFront_CD8_block19_x2_y8_patient337_1.json new file mode 100644 index 0000000000000000000000000000000000000000..92885e4a74f45f6d15e1bcb7aad2ee3dab266fef --- /dev/null +++ b/337/InvasionFront_CD8_block19_x2_y8_patient337_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 29759.2, + "Num Detections": 18830, + "Num Negative": 18533, + "Num Positive": 297, + "Positive %": 1.577, + "Num Positive per mm^2": 144.98 + } +} \ No newline at end of file diff --git a/337/TumorCenter_CD3_block19_x1_y8_patient337_0.json b/337/TumorCenter_CD3_block19_x1_y8_patient337_0.json new file mode 100644 index 0000000000000000000000000000000000000000..398b46e54c4bceb9f67791eb5827ec0935a19eeb --- /dev/null +++ b/337/TumorCenter_CD3_block19_x1_y8_patient337_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5547.1, + "Centroid Y µm": 22263.2, + "Num Detections": 13489, + "Num Negative": 11888, + "Num Positive": 1601, + "Positive %": 11.87, + "Num Positive per mm^2": 854.44 + } +} \ No newline at end of file diff --git a/337/TumorCenter_CD3_block19_x2_y8_patient337_1.json b/337/TumorCenter_CD3_block19_x2_y8_patient337_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e0bbaa039eac982f33fd0df02543683cb6fa06a --- /dev/null +++ b/337/TumorCenter_CD3_block19_x2_y8_patient337_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7920.8, + "Centroid Y µm": 21913.4, + "Num Detections": 11686, + "Num Negative": 11117, + "Num Positive": 569, + "Positive %": 4.869, + "Num Positive per mm^2": 379.15 + } +} \ No newline at end of file diff --git a/337/TumorCenter_CD8_block19_x1_y8_patient337_0.json b/337/TumorCenter_CD8_block19_x1_y8_patient337_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f50b6fe3fec530372e2caed1b2c1b115e48b968 --- /dev/null +++ b/337/TumorCenter_CD8_block19_x1_y8_patient337_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 31408.4, + "Num Detections": 16497, + "Num Negative": 15372, + "Num Positive": 1125, + "Positive %": 6.819, + "Num Positive per mm^2": 568.4 + } +} \ No newline at end of file diff --git a/337/TumorCenter_CD8_block19_x2_y8_patient337_1.json b/337/TumorCenter_CD8_block19_x2_y8_patient337_1.json new file mode 100644 index 0000000000000000000000000000000000000000..741a5a3480749b48a8f8c1c55e18ca02a1c90a83 --- /dev/null +++ b/337/TumorCenter_CD8_block19_x2_y8_patient337_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9245.1, + "Centroid Y µm": 31333.4, + "Num Detections": 12617, + "Num Negative": 12357, + "Num Positive": 260, + "Positive %": 2.061, + "Num Positive per mm^2": 167.28 + } +} \ No newline at end of file diff --git a/337/history_text.txt b/337/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/337/icd_codes.txt b/337/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/337/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/337/ops_codes.txt b/337/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf11dc03b554c378e4d74f0e2c32b3e0a71bbdc6 --- /dev/null +++ b/337/ops_codes.txt @@ -0,0 +1 @@ +Sonstige partielle Laryngektomie[5-302.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/337/patient_clinical_data.json b/337/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..61a51914e07ec84ccef61a1acd9b7a3831589f2f --- /dev/null +++ b/337/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 48, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/337/patient_pathological_data.json b/337/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bde7c33bf177ebb5ce5465cae2c8fa172d4be39f --- /dev/null +++ b/337/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "337", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 2, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/337/surgery_description.txt b/337/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a86ebca2b96a3ba78faf1382eb5aa216f45b0721 --- /dev/null +++ b/337/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngectomy and Panendoscopy diff --git a/337/surgery_report.txt b/337/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b1c1d79e2bf8ee0863f3cd3d942af2f2bf37298a --- /dev/null +++ b/337/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Entry with the small bore tube and inspection of the tumor. The tumor is very difficult to locate. There is an exophytic mass in the area of the right vocal fold with transition into the anterior commissure and onto the left vocal fold. In the area of the right vocal fold, the mass extends to the vocal process and into the morgue sinus. On the left side, the mass extends to the posterior third of the vocal fold and also into the morgue sinus. The folds of the pocket are only partially affected, if at all, on the right side. Due to the poor adjustability, partial laryngectomy from the outside. Therefore sterile washing and draping. Zigzag skin incision. Exposure of the prelarygneal musculature. Push the prelaryngeal muscles to the side. Incision of the perichondrium on the thyroid cartilage. Pushing off the perichondrium. Incision of the thyroid cartilage in the median. The thyrohyoid membrane was previously split in the middle. Opening of the larynx and inspection of the tumor. The tumor is located as described above. First, the right side of the thyroid cartilage is removed. This is successful without any problems. Deposition of the vocal process with the Kittel scissors in the posterior region. Deposition of the tumor on the subglottic slope and in the area of the morgue sinus. On the anterior part, the tumor extends slightly into the pocket fold, so part of the pocket fold is removed here. Transition to the left side. Here the tumor is also pushed away from the thyroid cartilage and deposited in the posterior third of the vocal fold. Removal of the morgue sinus and placement of the tumor in the anterior commissure. This results in tearing of the tumor. There is no infiltration of the thyroid cartilage in any areas. The tumor ruptures in the anterior commissure and is thread-marked in two pieces for final histology. Samples are taken from all margins as well as from the depth. All marginal samples are in frozen section R0. Transition to reconstruction of the larynx. First, the mucosa of the pocket fold is sutured to the mucosa of the subglottic region on the left side. Insertion of two drill holes through the thyroid cartilage in the area of the anterior commissure. Here, the pocket fold in the left area is fixed forward so that ultimately no thyroid cartilage is exposed. The same procedure is performed on the right side. On the right side, however, a small section in the anterior region can no longer be closed. This means that the mucosa of the pocket fold cannot be connected to the subglottic region in this area, as too much mucosa has been resected here. However, it is possible to fix the pocket fold to the anterior commissure on the right side in order to leave all edges of the anterior commissure covered with mucosa to prevent synechiae from forming. Finally, drill holes in the posterior area and suture the thyroid cartilage. Suturing of the remaining soft tissues, perichondrium, muscle fascia, muscle and subcutaneous tissue in layers. A flap was previously inserted. Application of a pressure bandage. A tracheostomy was not performed intraoperatively if the wound conditions were good. The patient should be fed via the inserted nasogastric tube for at least five days. The patient should then be carefully fed and presented at the tumor conference. Please plan a follow-up MLE in 8 weeks. \ No newline at end of file diff --git a/338/InvasionFront_CD3_block18_x5_y11_patient338_0.json b/338/InvasionFront_CD3_block18_x5_y11_patient338_0.json new file mode 100644 index 0000000000000000000000000000000000000000..71f18a089ff7e04e71c17788bb84f44fd54f3a1a --- /dev/null +++ b/338/InvasionFront_CD3_block18_x5_y11_patient338_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15516.8, + "Centroid Y µm": 32432.8, + "Num Detections": 14417, + "Num Negative": 13761, + "Num Positive": 656, + "Positive %": 4.55, + "Num Positive per mm^2": 348.37 + } +} \ No newline at end of file diff --git a/338/InvasionFront_CD3_block18_x6_y11_patient338_1.json b/338/InvasionFront_CD3_block18_x6_y11_patient338_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6012b637d02e70252d09eb12ab517195be1a4acd --- /dev/null +++ b/338/InvasionFront_CD3_block18_x6_y11_patient338_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17965.5, + "Centroid Y µm": 32782.6, + "Num Detections": 12812, + "Num Negative": 12689, + "Num Positive": 123, + "Positive %": 0.96, + "Num Positive per mm^2": 74.21 + } +} \ No newline at end of file diff --git a/338/InvasionFront_CD8_block18_x5_y11_patient338_0.json b/338/InvasionFront_CD8_block18_x5_y11_patient338_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1dbb273c435c2685e9fddd25e25375c96e553d41 --- /dev/null +++ b/338/InvasionFront_CD8_block18_x5_y11_patient338_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 34731.6, + "Num Detections": 13850, + "Num Negative": 13216, + "Num Positive": 634, + "Positive %": 4.578, + "Num Positive per mm^2": 345.03 + } +} \ No newline at end of file diff --git a/338/InvasionFront_CD8_block18_x6_y11_patient338_1.json b/338/InvasionFront_CD8_block18_x6_y11_patient338_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f7c1a771a304fec32c45ab2bee80fe5618016c26 --- /dev/null +++ b/338/InvasionFront_CD8_block18_x6_y11_patient338_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18733.7, + "Centroid Y µm": 34794.2, + "Num Detections": 11368, + "Num Negative": 11302, + "Num Positive": 66, + "Positive %": 0.5806, + "Num Positive per mm^2": 48.18 + } +} \ No newline at end of file diff --git a/338/TumorCenter_CD3_block18_x5_y11_patient338_0.json b/338/TumorCenter_CD3_block18_x5_y11_patient338_0.json new file mode 100644 index 0000000000000000000000000000000000000000..845c958c49db136a095052894ad6bdba735b89ff --- /dev/null +++ b/338/TumorCenter_CD3_block18_x5_y11_patient338_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15522.1, + "Centroid Y µm": 26645.2, + "Num Detections": 9315, + "Num Negative": 8916, + "Num Positive": 399, + "Positive %": 4.283, + "Num Positive per mm^2": 232.01 + } +} \ No newline at end of file diff --git a/338/TumorCenter_CD3_block18_x6_y11_patient338_1.json b/338/TumorCenter_CD3_block18_x6_y11_patient338_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2abd8ec796c94afe9f06ecfa938bee87e60dc381 --- /dev/null +++ b/338/TumorCenter_CD3_block18_x6_y11_patient338_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17915.5, + "Centroid Y µm": 26735.8, + "Num Detections": 18717, + "Num Negative": 17986, + "Num Positive": 731, + "Positive %": 3.906, + "Num Positive per mm^2": 392.6 + } +} \ No newline at end of file diff --git a/338/TumorCenter_CD8_block18_x5_y11_patient338_0.json b/338/TumorCenter_CD8_block18_x5_y11_patient338_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0d409e32b22ea0063041ca642b00004b254bc192 --- /dev/null +++ b/338/TumorCenter_CD8_block18_x5_y11_patient338_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15516.8, + "Centroid Y µm": 27635.4, + "Num Detections": 15094, + "Num Negative": 15078, + "Num Positive": 16, + "Positive %": 0.106, + "Num Positive per mm^2": 8.556 + } +} \ No newline at end of file diff --git a/338/TumorCenter_CD8_block18_x6_y11_patient338_1.json b/338/TumorCenter_CD8_block18_x6_y11_patient338_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65cda21183914bf665edf5f30ff36b6e858cd2a0 --- /dev/null +++ b/338/TumorCenter_CD8_block18_x6_y11_patient338_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17940.5, + "Centroid Y µm": 27685.3, + "Num Detections": 15536, + "Num Negative": 15531, + "Num Positive": 5, + "Positive %": 0.0322, + "Num Positive per mm^2": 2.709 + } +} \ No newline at end of file diff --git a/338/history_text.txt b/338/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/338/icd_codes.txt b/338/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..72439b3da128b1dadee5990f3bd3f013a69633f4 --- /dev/null +++ b/338/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 B] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/338/ops_codes.txt b/338/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3224c87561e8ce39ff71d593c4a8e41839ebf460 --- /dev/null +++ b/338/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Sonstige radikale zervikale Lymphadenektomie [Neck dissection][5-403.x B] \ No newline at end of file diff --git a/338/patient_clinical_data.json b/338/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5a5a718e10bbb08d764b241d441aa6ae6b6643c8 --- /dev/null +++ b/338/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 54, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin + docetaxel", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/338/patient_pathological_data.json b/338/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e64c3f30e0aa2139b455eefe1c8dd9a61f8b11cf --- /dev/null +++ b/338/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "338", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/338/surgery_description.txt b/338/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..864cd496e823c96b87d82d75019d624ae873bd16 --- /dev/null +++ b/338/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Selective Neck Dissection, Provox Vega Prosthesis diff --git a/338/surgery_report.txt b/338/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7dfb524bc8a69ed3882bdf4304aaea141ee8930c --- /dev/null +++ b/338/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first perform the tracheostomy. Incision of the trachea below the third tracheal clasp and insertion of the tube after reintubation of the patient. Subsequent infiltration with local anesthetic containing adrenaline in the area of the subsequent apron flap incision. Sterile washing and draping. Sharp formation of the apron flap subplatysmal and elevation and fixation upwards in the usual manner to beyond the hyoid bone. Now start with the neck dissection on the right side. Mobilize the sternocleidomastoid muscle while protecting the medial and lateral parts of the accessorius nerve. Exposure of the digastric muscle. Opening of the vascular nerve sheath and skeletonization of the internal jugular vein and the carotid artery. Regions II to V are then removed, sparing all non-lymphatic structures. Subsequently, the superior thyroid artery is ligated,.............. Hypoglossus. Now detach the constrictor pharyngis muscle from the thyroid cartilage. Release the piriform sinus. Separation of the prelaryngeal and prethyroid muscles and lateral displacement of the right thyroid lobe. Subsequent transition to the opposite side. Similar procedure with the same findings. A suspicious lymph node metastasis is found macroscopically in the area of the facial angle, which is of course also removed. After appropriate mobilization of the larynx, an incision is made at the lower edge of the cricoid cartilage. Dissection of a caudally pedicled mucosal flap, which is used to cover the tracheal chimney, in the usual way. Then dissect the larynx cranially. Enter the hypopharynx at the level of the arytenoid cartilage. Widen the incision to the right to ensure a good view of the tumor, which is mainly located on the left. The tumor is then released with a macroscopic safety margin of 0.5 to 1 cm. Cranially, parts of the vallecula and the base of the tongue are included in the resection. On subsequent inspection of the resected area, the impression is gained that the safety margin is somewhat smaller in the caudal resection area, both on the right and left. Therefore, resections are performed on both sides. The resulting mucosal defect is then circumcised and all specimens are sent for frozen section histological examination. These proved to be tumor-free. Only postcricoidal moderate dysplasia was found. Therefore, a resection and a further frozen section for normal histology are performed at this point. Subsequently, myotomy of the inferior constrictor muscle on the dorsal side of the hypopharynx. Insertion of a size 8 Provox Vega8 cannula. Completion of the tracheostoma by H-shaped incision of the third tracheal clasp and completion of the mucocutaneous anastomosis. Subsequent two-layer closure of the mucosal defect in a T-shape. The first layer contains an inverting continuous suture according to Conley. The second layer consists of the surrounding muscle tissue using a single button suture. Finally, three Redon drains are inserted on each side of the neck. Folding back the apron flap and two-layer wound closure with continuous skin suture by . Re-intubation of the patient onto a 10 mm tracheal cannula. Sterile wound dressing. End of the operation. Handover of the patient to anesthesia. Conclusion: Total laryngectomy with selective neck dissection of regions II to V on both sides, for supraglottic laryngeal carcinoma. Primary voice rehabilitation by insertion of a size 8 Provox-Vega prosthesis and myotomy of the contrictor pharyngis muscle. Insertion of a tracheal chimney according to Herrmann. Please carry out a postoperative X-ray broad swallow on the 7th to 10th day. If a fistula is excluded, removal of the gastric tube and start of oral nutrition and phonation. \ No newline at end of file diff --git a/339/InvasionFront_CD3_block4_x1_y6_patient339_0.json b/339/InvasionFront_CD3_block4_x1_y6_patient339_0.json new file mode 100644 index 0000000000000000000000000000000000000000..274152c32a656b4bc4a44757813d94518cd5ebf7 --- /dev/null +++ b/339/InvasionFront_CD3_block4_x1_y6_patient339_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 20938.9, + "Num Detections": 18562, + "Num Negative": 17262, + "Num Positive": 1300, + "Positive %": 7.004, + "Num Positive per mm^2": 724.2 + } +} \ No newline at end of file diff --git a/339/InvasionFront_CD3_block4_x2_y6_patient339_1.json b/339/InvasionFront_CD3_block4_x2_y6_patient339_1.json new file mode 100644 index 0000000000000000000000000000000000000000..af4b626859115797c566ccb7602a9f6c607c284d --- /dev/null +++ b/339/InvasionFront_CD3_block4_x2_y6_patient339_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9145.2, + "Centroid Y µm": 21063.8, + "Num Detections": 22328, + "Num Negative": 18859, + "Num Positive": 3469, + "Positive %": 15.54, + "Num Positive per mm^2": 1531.1 + } +} \ No newline at end of file diff --git a/339/InvasionFront_CD8_block4_x1_y6_patient339_0.json b/339/InvasionFront_CD8_block4_x1_y6_patient339_0.json new file mode 100644 index 0000000000000000000000000000000000000000..806f262ceb822dc88f2ffcc9d64ed78e3e004a33 --- /dev/null +++ b/339/InvasionFront_CD8_block4_x1_y6_patient339_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3792.6, + "Centroid Y µm": 19780.4, + "Num Detections": 18184, + "Num Negative": 15616, + "Num Positive": 2568, + "Positive %": 14.12, + "Num Positive per mm^2": 1363.2 + } +} \ No newline at end of file diff --git a/339/InvasionFront_CD8_block4_x2_y6_patient339_1.json b/339/InvasionFront_CD8_block4_x2_y6_patient339_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b76f2e33979f585f6911c8695b20278083acaa1 --- /dev/null +++ b/339/InvasionFront_CD8_block4_x2_y6_patient339_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6538.2, + "Centroid Y µm": 19859.6, + "Num Detections": 23286, + "Num Negative": 18790, + "Num Positive": 4496, + "Positive %": 19.31, + "Num Positive per mm^2": 2003.3 + } +} \ No newline at end of file diff --git a/339/TumorCenter_CD3_block4_x1_y6_patient339_0.json b/339/TumorCenter_CD3_block4_x1_y6_patient339_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a94e278311fce1f88e38309f254b8f9df02c8846 --- /dev/null +++ b/339/TumorCenter_CD3_block4_x1_y6_patient339_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 15341.9, + "Num Detections": 19530, + "Num Negative": 16111, + "Num Positive": 3419, + "Positive %": 17.51, + "Num Positive per mm^2": 1692.1 + } +} \ No newline at end of file diff --git a/339/TumorCenter_CD3_block4_x2_y6_patient339_1.json b/339/TumorCenter_CD3_block4_x2_y6_patient339_1.json new file mode 100644 index 0000000000000000000000000000000000000000..df5f68936062de7693bb6dd218dc1491a08a7290 --- /dev/null +++ b/339/TumorCenter_CD3_block4_x2_y6_patient339_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 15616.7, + "Num Detections": 24702, + "Num Negative": 20059, + "Num Positive": 4643, + "Positive %": 18.8, + "Num Positive per mm^2": 1877.8 + } +} \ No newline at end of file diff --git a/339/TumorCenter_CD8_block4_x1_y6_patient339_0.json b/339/TumorCenter_CD8_block4_x1_y6_patient339_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6c1e25dba6d4dd0b50f3c5f2708faa7a43027f1e --- /dev/null +++ b/339/TumorCenter_CD8_block4_x1_y6_patient339_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4122.8, + "Centroid Y µm": 14892.1, + "Num Detections": 20507, + "Num Negative": 14224, + "Num Positive": 6283, + "Positive %": 30.64, + "Num Positive per mm^2": 2877.9 + } +} \ No newline at end of file diff --git a/339/TumorCenter_CD8_block4_x2_y6_patient339_1.json b/339/TumorCenter_CD8_block4_x2_y6_patient339_1.json new file mode 100644 index 0000000000000000000000000000000000000000..921dbb2da9cfa49aa7dac15dc2b4fc0830cf570e --- /dev/null +++ b/339/TumorCenter_CD8_block4_x2_y6_patient339_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6771.4, + "Centroid Y µm": 15142.0, + "Num Detections": 27095, + "Num Negative": 19094, + "Num Positive": 8001, + "Positive %": 29.53, + "Num Positive per mm^2": 3093.1 + } +} \ No newline at end of file diff --git a/339/history_text.txt b/339/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..84ad974dffa5cbad27b75bc6991b5f8cc8e58a16 --- /dev/null +++ b/339/history_text.txt @@ -0,0 +1 @@ +In Mr. , a cervical metastasis on the left was confirmed by means of a gross needle biopsy. The panendoscopy performed at the same time showed no primary tumor. Likewise, no primary could be found in the PET-CT. \ No newline at end of file diff --git a/339/icd_codes.txt b/339/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..004ffe6440aa7e0a8c8d9c277754be3792736496 --- /dev/null +++ b/339/icd_codes.txt @@ -0,0 +1 @@ +CUP [Cancer of Unknown Primary][C80.0 L] \ No newline at end of file diff --git a/339/ops_codes.txt b/339/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f4c13da1ec8724a0bf2edd27b920f901f8db944 --- /dev/null +++ b/339/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie n.n.bez.[1-620.y ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Tonsillektomie mit Adenotomie Dissektionstechnik[5-282.0 ] Biopsie an der Mundhöhle onA[1-420.y ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 4 Regionen[5-403.30 L] \ No newline at end of file diff --git a/339/patient_clinical_data.json b/339/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7616a328476b8f21447d366448eb1d885d4253eb --- /dev/null +++ b/339/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/339/patient_pathological_data.json b/339/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..af24549cf0ba2000e9f4f0aaa0f0656a65421bab --- /dev/null +++ b/339/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "339", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 21, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/339/surgery_description.txt b/339/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..41b256f68475e37a5a0e359c1bc3c743bf098aca --- /dev/null +++ b/339/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, CUP Panendoscopy, Neck dissection, PE (Proximal esophagus) diff --git a/339/surgery_report.txt b/339/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7a3f9013d5aae52cf0db9eee1018c11e1dee941b --- /dev/null +++ b/339/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, tracheoscopy by the surgeon. The trachea is visible up to the bifurcation. Subsequent intubation by the anesthesia colleagues. Repositioning for hypopharyngo-laryngoscopy. Entry with the Kleinsasser C-tube and inspection of the base of the tongue, epiglottic vallecula, right and left piriform sinus, postcricoidal region and esophageal entrance. No pathological changes here. Using the large double spoon, several samples are now taken from the base of the tongue on the right and left sides, which are sent for final histology. The endolarynx is then adjusted. No pathological changes here either. Repositioning for tonsillectomy on both sides. Insertion of the McIVOR oral spatula and palpation of the base of the tongue, floor of the mouth and the tonsils on both sides. No pathological resistance here. The tonsils are symmetrical on both sides and relatively atrophic. Start with tonsillectomy on the right side. Mucosal incision at the upper fold. Exposure of the tonsil capsule. Extension of the mucosal incision at the anterior posterior arch caudally and successive detachment of the tonsil from the capsule with the rasparatorium while sparing the anterior and posterior palatal arch. Separation of the tonsil at the caudal pole and bipolar coagulation of the caudal pole. There is no bleeding in the tonsil lobe on the right. Insertion of a hydrogen-soaked swab. Approach for tonsillectomy on the left side. Identical procedure here. No bleeding here either, after exposing the tonsil capsule and detaching the tonsil up to the caudal pole. Here, too, the palatal arch was spared anteriorly and posteriorly. Also bipolar coagulation at the caudal tonsil pole. Insertion of a hydrogen-soaked swab. Removal of the hydrogen-soaked swab. No evidence of further bleeding. Insertion of the velotraction and visualization of the nasopharynx. The posterior edge of the septum is clear, the tubal bulges are also unremarkable. No indication of a pathological change. Incision with Beckmann's ring knife and removal of minimal residual adenoids. Hemostasis using a hydrogen-soaked swab. No evidence of further bleeding after removal of the swab. Transfer for esophagoscopy and PEG placement. Entering with the esophagoscope under constant air insufflation into the stomach and distension of the stomach. There is a clear diaphanoscopy, despite obesity. Under the lower left paramedian rib, sterile draping. Injection of Ultracaine. Incision and puncture of the trocar without complications. Subsequent placement of the PEG using the thread pull-through method without problems. Repositioning for neck dissection on the left side. Injection of 6 ml ultracaine solution. Creation of an arched skin incision starting at the mastoid, pulling along the posterior sternal border in an anterior direction. This incision is chosen because the relatively large metastasis is located on the anterior edge of the sternocleidomastoid. Sterile covering. Cut through the subcutaneous tissue. Exposure of the platysma and creation of the platysmal flap. Locate the sternocleidomastoid and dissect the anterior edge of the muscle in depth. Successive detachment of the muscle. The auricularis magnus nerve is exposed in the anterior region. This is dissected and displaced caudally without severing it. The omohypoid muscle is then exposed and the retractor is inserted caudally. It can be seen that at the anterior edge of the sternocleidomastoid muscle from level II b to III, the metastasis is directly adjacent to the muscle without infiltrating it. Successive detachment of the metastasis in the cranial region from the muscle and search for the digastric muscle. Dissection of the digastric muscle and insertion of the cranial retractor. The accessorius nerve can then be exposed. This is spared until the end of the operation. Now dissect around the large cervical metastasis and detach the metastasis from level I after exposing the submandibular gland, which is pulled cranially with the Langebeck. Dissection around level II b up to level III. Now successive release of the metastasis, whereby a little thick secretion is emptied from the metastasis in the cranial region. Now visualization of the internal jugular vein and the facial vein. The internal jugular vein is displaced posteriorly/dorsally by the tumor, but can be spared. Dissection also reveals the cervical vein, which is traced in an anterior and caudal direction and is also spared until the end of the operation. Another small lymph node is found caudal to the mass, which is removed with the entire neck preparation. Subsequent dissection along the cervical vascular sheath and detachment of the fatty tissue from levels II and III up to level IV, with ligation in the caudal area to avoid a chyle fistula. No intraoperative evidence of chyle flow. Now turn to level II a. Here, the remaining fatty tissue cranial to the accessorius nerve is successively detached from the scalene muscles and then removed. Finally, the wound is irrigated with H2O2 and Ringer's and checked for hemostasis, which is present. Insertion of a Redon drain. Two-layer wound closure and completion of the procedure without complications. Conclusion: No evidence of primarius in the CUP panendoscopy. A TE/AT and trial biopsy from the base of the tongue on the right, left and median as well as a neck dissection on the left were performed. \ No newline at end of file diff --git a/340/InvasionFront_CD3_block14_x1_y8_patient340_0.json b/340/InvasionFront_CD3_block14_x1_y8_patient340_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0182a16c7f447bc72d8b05df0ad917a30c517283 --- /dev/null +++ b/340/InvasionFront_CD3_block14_x1_y8_patient340_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4272.7, + "Centroid Y µm": 23562.5, + "Num Detections": 21747, + "Num Negative": 17916, + "Num Positive": 3831, + "Positive %": 17.62, + "Num Positive per mm^2": 1508.0 + } +} \ No newline at end of file diff --git a/340/InvasionFront_CD3_block14_x2_y8_patient340_1.json b/340/InvasionFront_CD3_block14_x2_y8_patient340_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d3f7dd73715d804cb31bf8a2af1c2d9694c049ed --- /dev/null +++ b/340/InvasionFront_CD3_block14_x2_y8_patient340_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6896.3, + "Centroid Y µm": 23662.5, + "Num Detections": 22159, + "Num Negative": 18457, + "Num Positive": 3702, + "Positive %": 16.71, + "Num Positive per mm^2": 1471.0 + } +} \ No newline at end of file diff --git a/340/InvasionFront_CD8_block14_x1_y8_patient340_0.json b/340/InvasionFront_CD8_block14_x1_y8_patient340_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1acb4ee9fd0bf834ff73b18247e9fddffdb6064d --- /dev/null +++ b/340/InvasionFront_CD8_block14_x1_y8_patient340_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4572.6, + "Centroid Y µm": 19364.7, + "Num Detections": 23315, + "Num Negative": 20087, + "Num Positive": 3228, + "Positive %": 13.85, + "Num Positive per mm^2": 1305.4 + } +} \ No newline at end of file diff --git a/340/InvasionFront_CD8_block14_x2_y8_patient340_1.json b/340/InvasionFront_CD8_block14_x2_y8_patient340_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f70666ca18328d2ee22eae1f74625c6f6b8243c4 --- /dev/null +++ b/340/InvasionFront_CD8_block14_x2_y8_patient340_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7096.2, + "Centroid Y µm": 19489.7, + "Num Detections": 22595, + "Num Negative": 17988, + "Num Positive": 4607, + "Positive %": 20.39, + "Num Positive per mm^2": 1873.5 + } +} \ No newline at end of file diff --git a/340/TumorCenter_CD3_block14_x1_y8_patient340_0.json b/340/TumorCenter_CD3_block14_x1_y8_patient340_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3075f86b0dfdf092aeb3c57a6c93a73cc6313c46 --- /dev/null +++ b/340/TumorCenter_CD3_block14_x1_y8_patient340_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4047.9, + "Centroid Y µm": 19864.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/340/TumorCenter_CD3_block14_x2_y8_patient340_1.json b/340/TumorCenter_CD3_block14_x2_y8_patient340_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cdd6e4ee9db22a4645fe067d5077423525fb3f63 --- /dev/null +++ b/340/TumorCenter_CD3_block14_x2_y8_patient340_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 20039.4, + "Num Detections": 12612, + "Num Negative": 10184, + "Num Positive": 2428, + "Positive %": 19.25, + "Num Positive per mm^2": 1678.1 + } +} \ No newline at end of file diff --git a/340/TumorCenter_CD8_block14_x1_y8_patient340_0.json b/340/TumorCenter_CD8_block14_x1_y8_patient340_0.json new file mode 100644 index 0000000000000000000000000000000000000000..04aee3c50a87042b15d6525f4298a9acd3d5f232 --- /dev/null +++ b/340/TumorCenter_CD8_block14_x1_y8_patient340_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3398.2, + "Centroid Y µm": 20464.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/340/TumorCenter_CD8_block14_x2_y8_patient340_1.json b/340/TumorCenter_CD8_block14_x2_y8_patient340_1.json new file mode 100644 index 0000000000000000000000000000000000000000..18a2700d6a99747afd3f3a66a2b435cee912eddc --- /dev/null +++ b/340/TumorCenter_CD8_block14_x2_y8_patient340_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5921.9, + "Centroid Y µm": 20489.2, + "Num Detections": 12757, + "Num Negative": 10622, + "Num Positive": 2135, + "Positive %": 16.74, + "Num Positive per mm^2": 1519.2 + } +} \ No newline at end of file diff --git a/340/history_text.txt b/340/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b9cc853c4038e4bdbb3f0aa7d9e12f3bc86762e5 --- /dev/null +++ b/340/history_text.txt @@ -0,0 +1 @@ +The patient had primary radiochemotherapy for a proximal esophageal carcinoma until <2014>. During the tumor follow-up in the radiation clinic, a lymph node metastasis in the right angle of the jaw was noticed, so the patient was sent to us for further staging. We found a soft palate carcinoma on the right anterior palatal arch and a palpatory induration in the sense of a posterior right tongue margin carcinoma both clinically and subsequently in the panendoscopy. In addition, a sample was taken at 2 sites on the posterior wall of the oropharynx during the panendoscopy and carcinoma in situ was detected twice, once with transition to an invasive carcinoma. Therefore indication for the above procedure. \ No newline at end of file diff --git a/340/icd_codes.txt b/340/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/340/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/340/ops_codes.txt b/340/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c1a1cf8008c3cb1a0634f14377416274226dd668 --- /dev/null +++ b/340/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/340/patient_clinical_data.json b/340/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f5e554144b480498a8e3b7d870690cabcc85c6eb --- /dev/null +++ b/340/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/340/patient_pathological_data.json b/340/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..92683ed4d502787aa85cc72a28c20fa76a10c465 --- /dev/null +++ b/340/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "340", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 17, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/340/surgery_description.txt b/340/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0bbd9d205e0d16126a3ab64862cf6c97951395c1 --- /dev/null +++ b/340/surgery_description.txt @@ -0,0 +1 @@ +Resection of tongue margin carcinoma, Modified radical neck dissection diff --git a/340/surgery_report.txt b/340/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b1b3b95f4534cb202068e6d0761c75dc63d6fe73 --- /dev/null +++ b/340/surgery_report.txt @@ -0,0 +1 @@ +First, the patient is brought into the operating room and actively identified. Then induction of anesthesia and intubation by the anesthesia colleagues. Carry out the team time-out. The surgeon then positions the patient. Insertion of the Mc Ivor oral catheter. First assessment of the back surface of the oropharynx. Here, scarred conditions, partially whitish, non-wipeable mucosal changes starting paramedian on the left to almost the pharyngeal side wall on the right. In addition, an approx. 8 mm large carcinoma was found on the anterior palatal arch on the right side with a central ulcer, of which no histology was taken in the preliminary examination. This will now be completely resected. Subsequently, multiple marginal samples are taken and everything is sent for frozen section. Here the finding of a further carcinoma (the 3rd) is confirmed. Tumor-free in the frozen section. A defect of approx. 2 x 1 cm is created here. However, the posterior palatal arch is not affected. Now proceed to resection of the tongue margin carcinoma posteriorly on the right, extending to the base of the tongue. Insert the Jennings retractor for this. The tongue is then ligated and pulled out. The tumor is then palpated extensively and the borders marked with the bipolar. Gradually remove the tumor with a safety distance of 0.5 to 1 cm using the electric needle. Palpate again and again. At the end, the tumor can be completely removed. Bleeding is stopped bipolar. Now all-round and deep marginal samples. A frozen section shows that there is no tumor here either, and the Mc Ivor oral spatula is inserted again and the back surface of the oropharynx is inspected. Here, whitish mucosal conditions with scarring starting paramedian on the left and running obliquely downwards on the right. The electric needle is now passed around these, primarily creating a defect of approx. 2 x 1 cm. This is then dissected downwards on the muscle layer so that it remains intact. The prevertebral fascia is not exposed. The defect then becomes correspondingly larger due to the surface tension and reaches a size of approx. 3 x 2 cm. Between 12 and 4 o'clock, the mucosa continues to appear whitish and is therefore resected again. Due to the already large defect, no marginal samples are taken here, but the absence of tumor is determined on these 2 specimens after telephone consultation with the pathology department. Here, too, there is no tumor. Now a small mass approx. 2 x 1 mm at the cranial left tonsil pole above the tonsil is removed, also with a small safety margin. Primarily not suspicious. Final histology here. Subsequent transfer of the operation for neck dissection to . First marking of the skin incision after skin ablation cervical right. Sterile draping. Creation of an anteriorly curved skin incision. Cut through the subcutaneous tissue and the platysma. Exposure and ligation of the various branches of the external jugular vein. Sparing of the auricularis magnus nerve. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, digaster muscle and accessorius nerve. Sparing of the above structures. Dissection along the internal jugular vein from caudal to cranial with exposure of the cervical vascular sheath along the entire length. In the area of region Ib and IIa, a highly suspicious mass was found, which was carefully dissected away from the internal jugular vein and removed in toto. Successive evacuation of the posterior and anterior neck specimen with removal of several conspicuous lymph nodes in regions III and IV. Repeated inspection. Dry conditions. Placement of a Redon drainage. Two-layer wound closure. Application of a pressure bandage. Completion of the procedure without complications. \ No newline at end of file diff --git a/341/InvasionFront_CD3_block22_x5_y5_patient341_0.json b/341/InvasionFront_CD3_block22_x5_y5_patient341_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1345e377f5ecb6e0b46fc4fd673f7985c8cc111e --- /dev/null +++ b/341/InvasionFront_CD3_block22_x5_y5_patient341_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16991.0, + "Centroid Y µm": 24137.2, + "Num Detections": 20851, + "Num Negative": 20627, + "Num Positive": 224, + "Positive %": 1.074, + "Num Positive per mm^2": 99.91 + } +} \ No newline at end of file diff --git a/341/InvasionFront_CD3_block22_x6_y5_patient341_1.json b/341/InvasionFront_CD3_block22_x6_y5_patient341_1.json new file mode 100644 index 0000000000000000000000000000000000000000..591fe8da80555e0c5cbcf6b9e3e55d0013c35367 --- /dev/null +++ b/341/InvasionFront_CD3_block22_x6_y5_patient341_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19489.7, + "Centroid Y µm": 24262.2, + "Num Detections": 18397, + "Num Negative": 17859, + "Num Positive": 538, + "Positive %": 2.924, + "Num Positive per mm^2": 269.78 + } +} \ No newline at end of file diff --git a/341/InvasionFront_CD8_block22_x5_y5_patient341_0.json b/341/InvasionFront_CD8_block22_x5_y5_patient341_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7b908b0f5b431c002390375f9baa423aec4512aa --- /dev/null +++ b/341/InvasionFront_CD8_block22_x5_y5_patient341_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19152.4, + "Centroid Y µm": 12368.5, + "Num Detections": 19235, + "Num Negative": 19041, + "Num Positive": 194, + "Positive %": 1.009, + "Num Positive per mm^2": 88.45 + } +} \ No newline at end of file diff --git a/341/InvasionFront_CD8_block22_x6_y5_patient341_1.json b/341/InvasionFront_CD8_block22_x6_y5_patient341_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f42cf240306b89e34e3002237f6b362e7d908914 --- /dev/null +++ b/341/InvasionFront_CD8_block22_x6_y5_patient341_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21663.5, + "Centroid Y µm": 12256.0, + "Num Detections": 16494, + "Num Negative": 16159, + "Num Positive": 335, + "Positive %": 2.031, + "Num Positive per mm^2": 182.88 + } +} \ No newline at end of file diff --git a/341/TumorCenter_CD3_block22_x5_y5_patient341_0.json b/341/TumorCenter_CD3_block22_x5_y5_patient341_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c00be395e12e87103d22e304db88c140bf4e023c --- /dev/null +++ b/341/TumorCenter_CD3_block22_x5_y5_patient341_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16540.7, + "Centroid Y µm": 13156.7, + "Num Detections": 14020, + "Num Negative": 13965, + "Num Positive": 55, + "Positive %": 0.3923, + "Num Positive per mm^2": 29.62 + } +} \ No newline at end of file diff --git a/341/TumorCenter_CD3_block22_x6_y5_patient341_1.json b/341/TumorCenter_CD3_block22_x6_y5_patient341_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e187de86de199fc5767021c2e9a784690ebf9760 --- /dev/null +++ b/341/TumorCenter_CD3_block22_x6_y5_patient341_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18945.4, + "Centroid Y µm": 12984.4, + "Num Detections": 18146, + "Num Negative": 18100, + "Num Positive": 46, + "Positive %": 0.2535, + "Num Positive per mm^2": 21.64 + } +} \ No newline at end of file diff --git a/341/TumorCenter_CD8_block22_x5_y5_patient341_0.json b/341/TumorCenter_CD8_block22_x5_y5_patient341_0.json new file mode 100644 index 0000000000000000000000000000000000000000..72dcc48c5392d52d00be8d90bb65cc59e7d3e350 --- /dev/null +++ b/341/TumorCenter_CD8_block22_x5_y5_patient341_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 22238.2, + "Num Detections": 15075, + "Num Negative": 15041, + "Num Positive": 34, + "Positive %": 0.2255, + "Num Positive per mm^2": 18.18 + } +} \ No newline at end of file diff --git a/341/TumorCenter_CD8_block22_x6_y5_patient341_1.json b/341/TumorCenter_CD8_block22_x6_y5_patient341_1.json new file mode 100644 index 0000000000000000000000000000000000000000..44348fa8eba209c31410799ddab481172bbec1b7 --- /dev/null +++ b/341/TumorCenter_CD8_block22_x6_y5_patient341_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21313.7, + "Centroid Y µm": 22038.3, + "Num Detections": 18286, + "Num Negative": 18269, + "Num Positive": 17, + "Positive %": 0.093, + "Num Positive per mm^2": 7.868 + } +} \ No newline at end of file diff --git a/341/history_text.txt b/341/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..123d6a7c74871d4ab90d61dbdf016fb3c52e059d --- /dev/null +++ b/341/history_text.txt @@ -0,0 +1 @@ +The patient is found to have a hypopharyngeal-laryngeal carcinoma confirmed by panendoscopy. With CT evidence of infiltration of the entire right hemilarynx, the above-mentioned procedure is indicated. \ No newline at end of file diff --git a/341/icd_codes.txt b/341/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/341/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/341/ops_codes.txt b/341/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..db004195b87a3d25661fe22fd613bf739ca3f89a --- /dev/null +++ b/341/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie: Mit Pharyngektomie: Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] Anlegen und Wechsel einer duodenalen oder jejunalen Ernährungssonde: Transnasal, n.n.bez.[8-125.0 ] \ No newline at end of file diff --git a/341/patient_clinical_data.json b/341/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..efc49fbb15fe1b8607626ea4eb168b1140f6722d --- /dev/null +++ b/341/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 49, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 9, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/341/patient_pathological_data.json b/341/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..db93202ec6e7ffcc29a0214e18dffcaee9098df8 --- /dev/null +++ b/341/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "341", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 48, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris1", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/341/surgery_description.txt b/341/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..368edd81f0e226bd90db7c9752fe59b5e6e0ca5c --- /dev/null +++ b/341/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/341/surgery_report.txt b/341/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0a7b9f815721a565446972ae23adf18d5b77e3b3 --- /dev/null +++ b/341/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesiologist. Repositioning of the patient and repeated endoscopic examination of the tumor region. The above-mentioned tumor extension is confirmed, so that the indication is confirmed. Subsequently, flexible esophagogastroscopy with PEG insertion with positive diaphanoscopy and positive tenting phenomenon using the thread pull-through method. This succeeds loco typico without any problems. Retraction of the esophagoscope and fixation of the PEG tube. Dressing is applied. Subsequent positioning of the patient and injection of local anesthetic with adrenaline in the area of the apron flap. Skin incision and dissection of the apron flap to expose the cervical vascular sheath and the anterior edge of the sternocleidomastoid muscle on both sides. Then start with the neck dissection on the left side. No suspicious lymph nodes are found during the dissection. Neck dissection is carried out in the area of levels Ib, II, III, IV and partially V. During neck dissection, the cervical vascular sheath is exposed over a long distance. Long-distance dissection, displacement and re-embedding of the vagus nerve in the sense of neurolysis. Long-distance dissection, displacement and re-embedding of the accessory nerve in the sense of a neurolysis. Same procedure in the area of the hypoglossal nerve. The entire neck preparation is sent for histopathological examination. Transition to the tumor side. Here, a lymph node conglomerate is seen in the area of the venous angle, which extends into the accessorius triangle. The number and size of the lymph nodes are also conspicuous down to level V. Here, too, the cervical vascular sheath is dissected over a long distance and the vagus nerve, accessory nerve and hypoglossal nerve are exposed, relocated and re-embedded in the sense of a neurolysis. Complete evacuation of the hypoglossal triangle and the accessorius triangle as well as the lateral and medial neck preparation, resulting in a level Ib to V neck dissection. All branches of the internal jugular vein and the external carotid artery can be preserved on both sides during dissection. Exposure of the hyoid bone and thyroid cartilage. Here, the hyoid bone is released from the cranial side by separating the suprahyoid muscles. Subsequent release of the posterior horn of the thyroid cartilage on both sides. This also involves severing the vascular nerve bundle. Exposure of the lateral surface of the thyroid cartilage on the left side and release of the pharyngeal tube. Caudal dissection of the thyroid lobe. It is clear that the thyroid lobe is not covered by the tumor on either side, especially not on the right side. In this case, the thyroid gland has been removed, but a marginal sample was taken for frozen section diagnosis. This was found to be tumor-free during the operation. In addition, the thyroid isthmus is cut, which is cut off on both sides, thus exposing the anterior surface of the trachea. The trachea is opened between the 1st and 2nd cartilage clasps and a visor tracheotomy is prepared, through which the patient is cannulated after extubation. Opening of the pharynx at the level of the epiglottis and preparation of the pharyngeal tube. Care is taken to ensure that the largest possible width of pharynx is retained on the left side. Carefully detach the pharynx from the laryngeal skeleton. This provides a very good view and control of the tumor. The tumor is incised far into the healthy tissue. The tumor extension described above is again confirmed, so that the option of a partial laryngeal resection is now definitively ruled out. The dissection continues caudally by further detaching the pharynx. At the level of the cricoid cartilage, where there is certainly no more tumor infiltration, further detachment of the larynx and subsequent removal of the larynx directly below the cricoid cartilage. Subsequent subtle hemostasis. Taking marginal samples from the tumor specimen. Here, the medial margin sample is infiltrated in a frozen section as a carcinoma in situ. However, due to the fact that the mucosa appears completely free of irritation and there is only a narrow margin of pharyngeal mucosa in the area of the caudal tumor deposit, the decision is made not to take any further margin samples in this area in order to avoid the need for pharyngeal reconstruction using a free flap graft. After subtle hemostasis, insertion of a Provox prosthesis in loco typico. This is also successful without any problems. Pharyngeal closure after performing the myotomy, which is performed laterally on both sides. Subsequent pharyngeal closure with single button sutures and then two layers of continuous sutures. The pharynx is closed at the base of the tongue in a horizontal scar line and otherwise in a vertical line. Dissection of the infrahyoid musculature, which was displaced caudally together with the thyroid gland. This is now also sutured in front of the pharynx and fixed to the base of the tongue. Repeated bleeding control in the area of the neck dissection. Dry wound conditions here too. The apron flap is then folded back and the tracheostoma sutured in place. Closure of the skin incision on both sides with subcutaneous and skin sutures. Insertion of a tracheal cannula. Application of a pressure bandage on both sides. Final consultation with the anesthetist. Completion of the procedure. To splint the pharynx, the nasogastric tube inserted at the beginning of the operation by the anesthesia colleagues remains in place postoperatively. Nutrition should be provided via the PEG. The patient is admitted to the in-house intensive care unit for postoperative monitoring. Swallowing attempt on the 10th postoperative day. \ No newline at end of file diff --git a/342/InvasionFront_CD3_block1_x5_y2_patient342_0.json b/342/InvasionFront_CD3_block1_x5_y2_patient342_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e318997ebead5dad055d0ffb8c2b618aee2f649d --- /dev/null +++ b/342/InvasionFront_CD3_block1_x5_y2_patient342_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16891.1, + "Centroid Y µm": 6996.3, + "Num Detections": 20160, + "Num Negative": 19897, + "Num Positive": 263, + "Positive %": 1.305, + "Num Positive per mm^2": 115.8 + } +} \ No newline at end of file diff --git a/342/InvasionFront_CD3_block1_x6_y2_patient342_1.json b/342/InvasionFront_CD3_block1_x6_y2_patient342_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a75f8807ecbac3659ba632c617ad02c2d10eb812 --- /dev/null +++ b/342/InvasionFront_CD3_block1_x6_y2_patient342_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19514.7, + "Centroid Y µm": 6971.3, + "Num Detections": 29895, + "Num Negative": 29182, + "Num Positive": 713, + "Positive %": 2.385, + "Num Positive per mm^2": 241.72 + } +} \ No newline at end of file diff --git a/342/InvasionFront_CD8_block1_x5_y2_patient342_0.json b/342/InvasionFront_CD8_block1_x5_y2_patient342_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e10ca6caeaabc916dc9f24132761e24137b3352a --- /dev/null +++ b/342/InvasionFront_CD8_block1_x5_y2_patient342_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17115.9, + "Centroid Y µm": 5747.0, + "Num Detections": 18062, + "Num Negative": 17580, + "Num Positive": 482, + "Positive %": 2.669, + "Num Positive per mm^2": 229.42 + } +} \ No newline at end of file diff --git a/342/InvasionFront_CD8_block1_x6_y2_patient342_1.json b/342/InvasionFront_CD8_block1_x6_y2_patient342_1.json new file mode 100644 index 0000000000000000000000000000000000000000..789170d2800f9c846f7837236656266c5c3481be --- /dev/null +++ b/342/InvasionFront_CD8_block1_x6_y2_patient342_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19789.5, + "Centroid Y µm": 5821.9, + "Num Detections": 30448, + "Num Negative": 29009, + "Num Positive": 1439, + "Positive %": 4.726, + "Num Positive per mm^2": 480.37 + } +} \ No newline at end of file diff --git a/342/TumorCenter_CD3_block1_x5_y4_patient342_0.json b/342/TumorCenter_CD3_block1_x5_y4_patient342_0.json new file mode 100644 index 0000000000000000000000000000000000000000..35a28e1f623ff306937c14918491afe16a9df12d --- /dev/null +++ b/342/TumorCenter_CD3_block1_x5_y4_patient342_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15566.8, + "Centroid Y µm": 10019.7, + "Num Detections": 19926, + "Num Negative": 19425, + "Num Positive": 501, + "Positive %": 2.514, + "Num Positive per mm^2": 213.49 + } +} \ No newline at end of file diff --git a/342/TumorCenter_CD3_block1_x6_y4_patient342_1.json b/342/TumorCenter_CD3_block1_x6_y4_patient342_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d7e2a5f8a4609b91d3379fe31552ab86abde8917 --- /dev/null +++ b/342/TumorCenter_CD3_block1_x6_y4_patient342_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 9944.7, + "Num Detections": 18882, + "Num Negative": 18525, + "Num Positive": 357, + "Positive %": 1.891, + "Num Positive per mm^2": 159.51 + } +} \ No newline at end of file diff --git a/342/TumorCenter_CD8_block1_x5_y2_patient342_0.json b/342/TumorCenter_CD8_block1_x5_y2_patient342_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0d7c011b2f509c75850089640c0d397c89e42ccb --- /dev/null +++ b/342/TumorCenter_CD8_block1_x5_y2_patient342_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 13767.7, + "Num Detections": 22921, + "Num Negative": 22299, + "Num Positive": 622, + "Positive %": 2.714, + "Num Positive per mm^2": 240.34 + } +} \ No newline at end of file diff --git a/342/TumorCenter_CD8_block1_x6_y2_patient342_1.json b/342/TumorCenter_CD8_block1_x6_y2_patient342_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6bf52f9a0e3fd8bdae031c763c0791a29b9a17c9 --- /dev/null +++ b/342/TumorCenter_CD8_block1_x6_y2_patient342_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21238.8, + "Centroid Y µm": 13717.7, + "Num Detections": 23614, + "Num Negative": 22790, + "Num Positive": 824, + "Positive %": 3.489, + "Num Positive per mm^2": 334.02 + } +} \ No newline at end of file diff --git a/342/history_text.txt b/342/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/342/icd_codes.txt b/342/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d1dcbef33712e70bb537f5f0d27e46c0f20ebcd --- /dev/null +++ b/342/icd_codes.txt @@ -0,0 +1 @@ +Uvulakarzinom[C05.2 ] \ No newline at end of file diff --git a/342/ops_codes.txt b/342/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e67af8e36cd1cff3fbbf1bc3c17ef1d557c693a3 --- /dev/null +++ b/342/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Exstirpation total transoral (erkrankter) harter und weicher Gaumen[5-272.2 ] \ No newline at end of file diff --git a/342/patient_clinical_data.json b/342/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a11f9563d7fdf7a3b24ff437da6710e55dfdebe0 --- /dev/null +++ b/342/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/342/patient_pathological_data.json b/342/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9bd08c4af8c2d3cfe2dc37694caf5be2890e203b --- /dev/null +++ b/342/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "342", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/342/surgery_description.txt b/342/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7fd7b8d535157b7de19a82fd7258f302c34f9962 --- /dev/null +++ b/342/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Excisional biopsy diff --git a/342/surgery_report.txt b/342/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1d88340fba2293c6bc1187a71ac3d304b203ccfb --- /dev/null +++ b/342/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Entry with the Kleinsasser tube and inspection of the hypopharynx and larynx. No abnormalities in the laryngeal region. Piriform sinus unremarkable on both sides. Posterior pharyngeal wall unremarkable. There is a distal hypopharyngeal diverticulum on the left side. Easy passage of the threshold with the flexible esophagogastroscope and projection to the stomach. There is only a residual stomach after partial gastric resection. As far as can be assessed, there are no abnormalities of the mucosa. Insertion of the tonsillectomy tube and inspection of the oropharynx. An exophytic mass approx. 1 cm in size is found on the uvula. Now remove the uvula including the carcinoma at the base. The specimen is thread-marked for final histology. \ No newline at end of file diff --git a/343/InvasionFront_CD3_block2_x1_y7_patient343_0.json b/343/InvasionFront_CD3_block2_x1_y7_patient343_0.json new file mode 100644 index 0000000000000000000000000000000000000000..304da81aa9d3a13ef3a978842f609e257a36a540 --- /dev/null +++ b/343/InvasionFront_CD3_block2_x1_y7_patient343_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 30858.7, + "Num Detections": 14047, + "Num Negative": 13453, + "Num Positive": 594, + "Positive %": 4.229, + "Num Positive per mm^2": 310.73 + } +} \ No newline at end of file diff --git a/343/InvasionFront_CD3_block2_x2_y7_patient343_1.json b/343/InvasionFront_CD3_block2_x2_y7_patient343_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e5c47354825435391798378ec9e8bcf72455fc6a --- /dev/null +++ b/343/InvasionFront_CD3_block2_x2_y7_patient343_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8970.3, + "Centroid Y µm": 30758.7, + "Num Detections": 24564, + "Num Negative": 24328, + "Num Positive": 236, + "Positive %": 0.9608, + "Num Positive per mm^2": 98.19 + } +} \ No newline at end of file diff --git a/343/InvasionFront_CD8_block2_x1_y7_patient343_0.json b/343/InvasionFront_CD8_block2_x1_y7_patient343_0.json new file mode 100644 index 0000000000000000000000000000000000000000..666ddf1b2d812d51c0d3de56af5f342bfd63bec8 --- /dev/null +++ b/343/InvasionFront_CD8_block2_x1_y7_patient343_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5197.2, + "Centroid Y µm": 18515.2, + "Num Detections": 14506, + "Num Negative": 14003, + "Num Positive": 503, + "Positive %": 3.468, + "Num Positive per mm^2": 248.44 + } +} \ No newline at end of file diff --git a/343/InvasionFront_CD8_block2_x2_y7_patient343_1.json b/343/InvasionFront_CD8_block2_x2_y7_patient343_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0af2d1c9b48f4f746d2185992820d624d2fc4d6 --- /dev/null +++ b/343/InvasionFront_CD8_block2_x2_y7_patient343_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7820.9, + "Centroid Y µm": 18415.2, + "Num Detections": 23206, + "Num Negative": 20881, + "Num Positive": 2325, + "Positive %": 10.02, + "Num Positive per mm^2": 1000.5 + } +} \ No newline at end of file diff --git a/343/TumorCenter_CD3_block2_x1_y7_patient343_0.json b/343/TumorCenter_CD3_block2_x1_y7_patient343_0.json new file mode 100644 index 0000000000000000000000000000000000000000..33f53283fb130f65c4196744b697f2dcbc20ba89 --- /dev/null +++ b/343/TumorCenter_CD3_block2_x1_y7_patient343_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 16816.1, + "Num Detections": 21793, + "Num Negative": 20905, + "Num Positive": 888, + "Positive %": 4.075, + "Num Positive per mm^2": 405.89 + } +} \ No newline at end of file diff --git a/343/TumorCenter_CD3_block2_x2_y7_patient343_1.json b/343/TumorCenter_CD3_block2_x2_y7_patient343_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c06699a248089ffc96390bfd852bd3fff186231f --- /dev/null +++ b/343/TumorCenter_CD3_block2_x2_y7_patient343_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 16866.1, + "Num Detections": 21592, + "Num Negative": 19837, + "Num Positive": 1755, + "Positive %": 8.128, + "Num Positive per mm^2": 705.44 + } +} \ No newline at end of file diff --git a/343/TumorCenter_CD8_block2_x1_y7_patient343_0.json b/343/TumorCenter_CD8_block2_x1_y7_patient343_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2f758d7e4e2edc7c234c9905e3dabc5907b49a87 --- /dev/null +++ b/343/TumorCenter_CD8_block2_x1_y7_patient343_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5821.9, + "Centroid Y µm": 17390.8, + "Num Detections": 21057, + "Num Negative": 19224, + "Num Positive": 1833, + "Positive %": 8.705, + "Num Positive per mm^2": 885.22 + } +} \ No newline at end of file diff --git a/343/TumorCenter_CD8_block2_x2_y7_patient343_1.json b/343/TumorCenter_CD8_block2_x2_y7_patient343_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ba2bab24904d9e70fd8e5aec4c11cb49a4691127 --- /dev/null +++ b/343/TumorCenter_CD8_block2_x2_y7_patient343_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8420.5, + "Centroid Y µm": 17215.9, + "Num Detections": 23940, + "Num Negative": 23423, + "Num Positive": 517, + "Positive %": 2.16, + "Num Positive per mm^2": 203.66 + } +} \ No newline at end of file diff --git a/343/history_text.txt b/343/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/343/icd_codes.txt b/343/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..38d76f9304569863d2ad996209bc4fcde6301d75 --- /dev/null +++ b/343/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Uvula[C05.2 ] \ No newline at end of file diff --git a/343/ops_codes.txt b/343/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6333440c7c3dbd0846a2c6fed4a62e82de81ae7a --- /dev/null +++ b/343/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] \ No newline at end of file diff --git a/343/patient_clinical_data.json b/343/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f36719b470732c23789c1eb5c0ff08611669e535 --- /dev/null +++ b/343/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 63, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/343/patient_pathological_data.json b/343/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1593db0d9bf755d1d37fcc29945090ebf4c029a2 --- /dev/null +++ b/343/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "343", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 61, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/343/surgery_description.txt b/343/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2ffe92b559910b4285629a0ef268c29d963c095a --- /dev/null +++ b/343/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy and Panendoscopy diff --git a/343/surgery_report.txt b/343/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4bb3f9ebba4e23a923d290d9fa90a8cb9a59ba13 --- /dev/null +++ b/343/surgery_report.txt @@ -0,0 +1 @@ +After the anesthesia has been deepened by the anesthesia colleagues, the tracheoscopy is performed. The trachea is found to be normal on all sides. Intubation by the anesthesia colleagues. Flexible esophagogastroscopy under visualization with constant air insufflation. Advancement of the flexible esophagoscope into the stomach. This is unremarkable on all sides. The flexible esophagoscope is then withdrawn and the esophagus is inspected. Several multiple, extensive mucosal changes without invasive signs are seen, the largest of which is approx. 35 cm from the dentate line. Demonstration of findings to . This recommends further gastroenterological clarification. In the case of multiple findings, a sample was not taken. Systemic examination of the oral cavity, oropharynx and hypopharynx including endolarynx and piriform sinus on both sides. A cT1 central uvular carcinoma was found. Secondary findings: Multiple vallecula cysts and retention cyst of the lower lip on the right. Insertion of the TE blocker. Velotractio using catheter suction. Focal inspection of the tumor on the uvula. A tumor with a diameter of 1 cm can be seen in the middle of the uvula. Epipharyngeal inspection shows no evidence of cranial extension of the tumor. Therefore, decision to perform an excisional biopsy, together with in alternation. Cut through the tissue with a safety margin from anterior to posterior in an oblique direction. Complete removal of the uvula using an electric needle with a safety distance of at least 1 cm. The suture is then marked. The tissue is sent for final histology. Hemostasis using a bipolar. Relaxation of the oral retractor. Re-inspection of the surgical site. Blood dryness is seen here. Then discussion with about the retention cyst on the lower lip. The finding is not oncologically relevant, therefore no further measures. Conclusion: Excision biopsy of a cT1 uvula carcinoma in the center. Waiting for the final histology and case discussion in our tumor conference. \ No newline at end of file diff --git a/344/InvasionFront_CD3_block13_x3_y5_patient344_0.json b/344/InvasionFront_CD3_block13_x3_y5_patient344_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fd48480f8b6295a3d94b3271f01dc090f368f86b --- /dev/null +++ b/344/InvasionFront_CD3_block13_x3_y5_patient344_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 11743.8, + "Num Detections": 18146, + "Num Negative": 17986, + "Num Positive": 160, + "Positive %": 0.8817, + "Num Positive per mm^2": 79.2 + } +} \ No newline at end of file diff --git a/344/InvasionFront_CD3_block13_x4_y5_patient344_1.json b/344/InvasionFront_CD3_block13_x4_y5_patient344_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e585ef50c7243eb502e253ff18136b150fda09a --- /dev/null +++ b/344/InvasionFront_CD3_block13_x4_y5_patient344_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 11793.8, + "Num Detections": 18515, + "Num Negative": 17967, + "Num Positive": 548, + "Positive %": 2.96, + "Num Positive per mm^2": 274.23 + } +} \ No newline at end of file diff --git a/344/InvasionFront_CD8_block13_x3_y5_patient344_0.json b/344/InvasionFront_CD8_block13_x3_y5_patient344_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c624539826d9067e3944f4d50ff7d7747111f279 --- /dev/null +++ b/344/InvasionFront_CD8_block13_x3_y5_patient344_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12218.5, + "Centroid Y µm": 13367.9, + "Num Detections": 19060, + "Num Negative": 18672, + "Num Positive": 388, + "Positive %": 2.036, + "Num Positive per mm^2": 184.79 + } +} \ No newline at end of file diff --git a/344/InvasionFront_CD8_block13_x4_y5_patient344_1.json b/344/InvasionFront_CD8_block13_x4_y5_patient344_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fbd931175da9a8fa80e749e8755b3eaf0ba43f31 --- /dev/null +++ b/344/InvasionFront_CD8_block13_x4_y5_patient344_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14842.1, + "Centroid Y µm": 13492.9, + "Num Detections": 21101, + "Num Negative": 20505, + "Num Positive": 596, + "Positive %": 2.825, + "Num Positive per mm^2": 280.79 + } +} \ No newline at end of file diff --git a/344/TumorCenter_CD3_block13_x3_y5_patient344_0.json b/344/TumorCenter_CD3_block13_x3_y5_patient344_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6abbf20f96b31d6b1b2a35962d815084c0e64cbe --- /dev/null +++ b/344/TumorCenter_CD3_block13_x3_y5_patient344_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12168.6, + "Centroid Y µm": 18865.0, + "Num Detections": 23153, + "Num Negative": 22782, + "Num Positive": 371, + "Positive %": 1.602, + "Num Positive per mm^2": 153.43 + } +} \ No newline at end of file diff --git a/344/TumorCenter_CD3_block13_x4_y5_patient344_1.json b/344/TumorCenter_CD3_block13_x4_y5_patient344_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf12a84d468c2f40891f5964bf170d6c7514cbcc --- /dev/null +++ b/344/TumorCenter_CD3_block13_x4_y5_patient344_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14642.2, + "Centroid Y µm": 19039.9, + "Num Detections": 19647, + "Num Negative": 19224, + "Num Positive": 423, + "Positive %": 2.153, + "Num Positive per mm^2": 192.32 + } +} \ No newline at end of file diff --git a/344/TumorCenter_CD8_block13_x3_y5_patient344_0.json b/344/TumorCenter_CD8_block13_x3_y5_patient344_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c6ebe76f88cb48373425c81bc881912843d586fe --- /dev/null +++ b/344/TumorCenter_CD8_block13_x3_y5_patient344_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11493.9, + "Centroid Y µm": 12568.3, + "Num Detections": 21896, + "Num Negative": 21519, + "Num Positive": 377, + "Positive %": 1.722, + "Num Positive per mm^2": 159.45 + } +} \ No newline at end of file diff --git a/344/TumorCenter_CD8_block13_x4_y5_patient344_1.json b/344/TumorCenter_CD8_block13_x4_y5_patient344_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a79cef5aae87a03a59f28fe5062be33a7dc7b7ec --- /dev/null +++ b/344/TumorCenter_CD8_block13_x4_y5_patient344_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 12268.5, + "Num Detections": 20488, + "Num Negative": 20291, + "Num Positive": 197, + "Positive %": 0.9615, + "Num Positive per mm^2": 84.66 + } +} \ No newline at end of file diff --git a/344/history_text.txt b/344/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..27d1a8a6235b435142dcd78de2d644a803920965 --- /dev/null +++ b/344/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the right with widespread infiltration of the larynx. The above-mentioned operation was therefore indicated. \ No newline at end of file diff --git a/344/icd_codes.txt b/344/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0b3cbae91d0de18b52f016f4fb0eb0aee9e11c88 --- /dev/null +++ b/344/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] \ No newline at end of file diff --git a/344/ops_codes.txt b/344/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..59373da5b5a7e7ee3eccc4629c1c5ab621216be0 --- /dev/null +++ b/344/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Freier Lappen mit mikrovaskuläre Anastomose Haut und Unterhaut Empfängerstelle Hals[5-905.05 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 B] Vollhautdeckung großflächig Empfängerstelle Unterarm[5-902.68 L] Entnahme von Vollhaut am Oberschenkel[5-901.1e R] Revision einer Blutgefäßoperation: Wechsel eines vaskulären Implantates[5-394.3 ] Revision einer Blutgefäßoperation: Wechsel eines vaskulären Implantates[5-394.3 ] Permanente Tracheostomie: Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/344/patient_clinical_data.json b/344/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..16b6c818165e72debbe7c153539aaf5a0192d662 --- /dev/null +++ b/344/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/344/patient_pathological_data.json b/344/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..75e2462e2b8a70efc0808d5cfea5c8969813b697 --- /dev/null +++ b/344/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "344", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 18.0 +} \ No newline at end of file diff --git a/344/surgery_description.txt b/344/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e359bee65fe23a20a6133dde056b81f377678ee6 --- /dev/null +++ b/344/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Defect coverage, Free flap (Radial) diff --git a/344/surgery_report.txt b/344/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c79c1750ed2db70f042796fd6ee1c2554cc571e5 --- /dev/null +++ b/344/surgery_report.txt @@ -0,0 +1 @@ +Dictation : Pharyngoscopy/laryngoscopy: The exophytic tumor is visible, which completely fills the piriform sinus, infiltrates the larynx over a wide area, occupies almost the entire postcricoid region, extends into the piriform apex and also extends into the piriform sinus lateral wall with small flat extensions. Indication for surgery thus confirmed. Repositioning of the patient, skin disinfection and sterile draping of all surgical areas. First start with neck dissection and pharyngectomy: injection of a total of 10 ml Ultracaine with adrenaline into both sides of the neck along the apron incision. Then first subplatysmal dissection of the apron flap in the typical manner up to the level of the hyoid bone or submandibular gland. Then start with the neck dissection on the right: dissection of the fat-lymph node preparation of the sternocleidomastoid muscle. Exposure of digastric muscle, omohyoid muscle and infrahyoid muscles. Exposure of the cervical vascular sheath, internal/external carotid artery, internal jugular vein, vagus nerve, accessorius nerve, hypoglossal nerve. Clearing of neck levels II to V while preserving the branches of the cervical plexus. Glandula submandibularis remains in situ. Subsequent neck dissection on the left side: Here the procedure is the same, but only removal of levels II to IV and small parts of V. Then laryngectomy: Exposure of the hyoid bone. This is separated from the suprahyoid musculature. Removal of the preglottic fatty tissue with dissection up to the entrance to the pharynx. Expose the superior chorda. Dissection of the superior pharyngeal constrictor muscle. This is dissected to the right of the hyoid bone, but not resected further. The thyroid gland is dissected away caudolaterally on the right and the thyroid isthmus is separated after clamping and puncture ligation. Same procedure on the left. Dissection of the pharyngeal constrictor muscle and release of the piriform sinus. Also dissection of the thyroid gland caudolaterally. Then enter the epiglottis into the laryngeal or pharyngeal space. Exposure of the tumor. This is resected at a distance of 1 to 1.5 mm in the tumor border area, in the pharyngeal area. Microscopic inspection reveals extensions, the entire right pharyngeal wall falls just above the midline. On the left, the largest part of the pharynx can be preserved. In the area of the sinus tip, the defect is too large for a primary suture. The suture-marked preparation is sent to ....................... for frozen section histology. The tumor appears relatively close to the right side in the area of the transition from the postcricoid region to the laryngeal skeleton. Therefore, adjacent soft tissue in the form of fatty tissue, pharyngeal wall tissue and also thyroid tissue is resected from the upper pole and sent in as a right basal margin specimen. This was found to be tumor-free in the frozen section. Carcinoma in situ in the area of the entire right border. Also caudally at the transition to the esophagus. Therefore, a resection was performed using a mucosal strip several mm thick, certainly 5 to 7 mm thick, certainly 1 cm thick, from the area of the right pharyngeal wall down to the postcricoid area and the border to the pharyngeal area on the left. Then a marginal sample from the same area. This is now sent for frozen section histology. No more infiltrates here. Thus, apart from possible skip growth, the resection is R0. Myotomy of the constrictor pharyngis muscle, pars fundiformis on the left side slightly dorsally. This widens the relatively narrow esophageal opening. After the resection, a radial flap is always indicated to cover the defect. Irrigation of the entire wound area with hydrogen and Ringer's solution and careful hemostasis. Dictation : Flap elevation of the radialis flap and coverage with split skin from the right thigh. After specifying a required graft of 11 x 9.5 cm by with monitor island, the graft is first marked and aligned and then incised. Removal of the skin and preservation of the blood supply to the monitor. Due to the physiognomy of the patient, the width of the graft must be selected up to the extensor side. Subfascial release, careful radial exploration and preservation of the superficial ramus, radial nerve, but this must be neurolyzed over a long distance. This is ultimately successful. Maintenance of graft perfusion. Ulnar subfacial dissection, here careful dissection of the long superficial ulnar artery with clear kinking. Exposure of the radial artery. Clamping of the radial artery and later, after approx. 30 minutes without changing the good oxygen saturation of the hand, removal of the radial artery subfascially to develop the graft. Removal of the skin monitor while lifting a wide subfascial tissue anathema. Trace the graft or the vessels into the crook of the elbow, here the radial artery is isolated, the antosseous artery is relatively weak and is removed to obtain the pedicle length if the defect is extensive. There is a confluence of the superficial vein after elevation of the brachiocephalic vein with a wide bridge, which takes up the vein ............. of the radial artery and opens into a very strong cubital vein. In addition, 2 smaller venous outlets with drainage into the deep system are preserved. Careful hemostasis and, if the graft is vital on both sides, final placement of the graft after the supply and return vessels have been treated. The graft is then successively inserted into the pharyngeal defect using a special expansion suture in the area of the esophageal entrance. The operation is then handed over again. Incision of the radial flap: The flap measures 11 x 10 cm. It is sutured around the remaining remnants of the subtotally resected pharynx. This is done with 3-0 Vicryl single button sutures. In the area of the esophageal opening, incision and suturing of the triangular flap. Gastric tube already in place. A second row of sutures is made at the base of the tongue and on the sides. The infrahyoid musculature is sutured caudally over the flap connected to the esophagus, with the thyroid gland still lying over it. The flap is then connected to the vessels. The superior thyroid artery on the right is selected as well as a large outlet from the facial vein and a smaller outlet from a larger outgoing thyroid vein. After conditioning the vessels, suture the radial artery to the superior thyroid artery using 8-0 Vicryl single-button sutures. After opening the clamps, good arterial flow, good venous return. A larger outgoing vein from the facial vein is selected for the larger vein from the cephalic region. Anastomosis using a 4-0 coupler after measuring. After opening the clamps, good venous return, positive smear phenomenon. An outlet from the area of the deep venous system is connected to a small outlet from an outgoing thyroid vein, after measuring the width using a 2-0 coupler. Again, good venous return after opening the clamps. Positive smear phenomenon. Finally, careful hemostasis again. Any open veins, venous or arterial vessels are clipped or ligated. The skin monitor was sutured into the skin via a small median cranial incision, tension-free. Subsequent careful irrigation and hemostasis. Wound closure in layers with insertion of 2 Penrose drains on the right and one Redon drain on the left and epithelialization of the tracheostoma. Subsequently insertion of a 10 tracheal cannula, which is fixed with sutures. Completion of the procedure without complications. The patient is admitted to the interdisciplinary intensive care unit for postoperative monitoring. Flap control according to scheme by means of skin monitor control and Doppler sonography. Antibiotics continued for one week with Unacid. Feeding via the PEG tube for 10 days, then gruel and, if necessary, diet build-up. Overall cT4a hypopharyngeal carcinoma with infiltration of the larynx. Postoperative RT or RCT according to lymph node status. \ No newline at end of file diff --git a/345/InvasionFront_CD3_block9_x3_y11_patient345_0.json b/345/InvasionFront_CD3_block9_x3_y11_patient345_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6246232f144ace0e13f1301c2769b0ad58217096 --- /dev/null +++ b/345/InvasionFront_CD3_block9_x3_y11_patient345_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11094.1, + "Centroid Y µm": 28335.0, + "Num Detections": 19949, + "Num Negative": 19457, + "Num Positive": 492, + "Positive %": 2.466, + "Num Positive per mm^2": 212.25 + } +} \ No newline at end of file diff --git a/345/InvasionFront_CD3_block9_x4_y11_patient345_1.json b/345/InvasionFront_CD3_block9_x4_y11_patient345_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c3783074c7715457fa8a23f41ee6aefffba6e73 --- /dev/null +++ b/345/InvasionFront_CD3_block9_x4_y11_patient345_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 28734.8, + "Num Detections": 18750, + "Num Negative": 18183, + "Num Positive": 567, + "Positive %": 3.024, + "Num Positive per mm^2": 259.06 + } +} \ No newline at end of file diff --git a/345/InvasionFront_CD8_block9_x3_y11_patient345_0.json b/345/InvasionFront_CD8_block9_x3_y11_patient345_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d3a29446e075257886ae7c3bb6bfe7f562b75d69 --- /dev/null +++ b/345/InvasionFront_CD8_block9_x3_y11_patient345_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 31883.1, + "Num Detections": 20544, + "Num Negative": 19424, + "Num Positive": 1120, + "Positive %": 5.452, + "Num Positive per mm^2": 495.33 + } +} \ No newline at end of file diff --git a/345/InvasionFront_CD8_block9_x4_y11_patient345_1.json b/345/InvasionFront_CD8_block9_x4_y11_patient345_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e36abba00c02d675a878f467afa5d665f6d3ce94 --- /dev/null +++ b/345/InvasionFront_CD8_block9_x4_y11_patient345_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13992.6, + "Centroid Y µm": 32307.9, + "Num Detections": 19889, + "Num Negative": 18432, + "Num Positive": 1457, + "Positive %": 7.326, + "Num Positive per mm^2": 644.81 + } +} \ No newline at end of file diff --git a/345/TumorCenter_CD3_block9_x3_y11_patient345_0.json b/345/TumorCenter_CD3_block9_x3_y11_patient345_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5ed1f1f1ab3d780cff3485af2ca6a8fdbc238132 --- /dev/null +++ b/345/TumorCenter_CD3_block9_x3_y11_patient345_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 33057.5, + "Num Detections": 22562, + "Num Negative": 21425, + "Num Positive": 1137, + "Positive %": 5.039, + "Num Positive per mm^2": 456.74 + } +} \ No newline at end of file diff --git a/345/TumorCenter_CD3_block9_x4_y11_patient345_1.json b/345/TumorCenter_CD3_block9_x4_y11_patient345_1.json new file mode 100644 index 0000000000000000000000000000000000000000..79a218183ad9f339633e97fda2eff657e953db60 --- /dev/null +++ b/345/TumorCenter_CD3_block9_x4_y11_patient345_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 33157.4, + "Num Detections": 20931, + "Num Negative": 19578, + "Num Positive": 1353, + "Positive %": 6.464, + "Num Positive per mm^2": 571.6 + } +} \ No newline at end of file diff --git a/345/TumorCenter_CD8_block9_x3_y11_patient345_0.json b/345/TumorCenter_CD8_block9_x3_y11_patient345_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ca0bffdbe067619b14709ddc6376eebe800f65c8 --- /dev/null +++ b/345/TumorCenter_CD8_block9_x3_y11_patient345_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11618.8, + "Centroid Y µm": 28784.8, + "Num Detections": 21479, + "Num Negative": 18606, + "Num Positive": 2873, + "Positive %": 13.38, + "Num Positive per mm^2": 1147.7 + } +} \ No newline at end of file diff --git a/345/TumorCenter_CD8_block9_x4_y11_patient345_1.json b/345/TumorCenter_CD8_block9_x4_y11_patient345_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9d46f6be619ccc7c843ccad70f7ba80f1f92fd7d --- /dev/null +++ b/345/TumorCenter_CD8_block9_x4_y11_patient345_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 28909.7, + "Num Detections": 8607, + "Num Negative": 6345, + "Num Positive": 2262, + "Positive %": 26.28, + "Num Positive per mm^2": 1868.0 + } +} \ No newline at end of file diff --git a/345/history_text.txt b/345/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7b491e4f7da03f706a6443a0caf988fc985b9487 --- /dev/null +++ b/345/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tonsillar carcinoma on the right. Hence the above-mentioned indication for surgery. \ No newline at end of file diff --git a/345/icd_codes.txt b/345/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/345/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/345/ops_codes.txt b/345/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0f2d002de1285e7ad55e0ae1e86913c1fe8c7ece --- /dev/null +++ b/345/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 3 Regionen[5-403.02 R] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 4 Regionen[5-403.03 L] Partielle Resektion des Pharynx [Pharynxteilresektion]: Durch Pharyngotomie: Rekonstruktion mit gestieltem regionalen Lappen[5-295.12 ] Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Ohne Rekonstruktion[5-295.00 ] Lappenplastik an Haut und Unterhaut, Entnahmestelle: Gestielter Fernlappen: Hals[5-904.25 ] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/345/patient_clinical_data.json b/345/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c08ec36de7f30062155464b26d7c22f2fac51567 --- /dev/null +++ b/345/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 59, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 65, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/345/patient_pathological_data.json b/345/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..144195b641c92dfb922c333e5a0c3c27b74cb447 --- /dev/null +++ b/345/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "345", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 53, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/345/surgery_description.txt b/345/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5d9326fcb347ec202169582b0771e4c743393dce --- /dev/null +++ b/345/surgery_description.txt @@ -0,0 +1 @@ +Resection of oropharynx carcinoma, Bilateral neck dissection, Defect coverage (Platysma flap), Tracheostomy, Endoscopy diff --git a/345/surgery_report.txt b/345/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1d54bebfed758bc5f917d625012791d08cc4da6 --- /dev/null +++ b/345/surgery_report.txt @@ -0,0 +1 @@ +First, laryngoscopy and pharyngoscopy again: The relatively small, exophytic tumor is seen in the area of the left tonsil lobe. Palpation shows clear infiltration into the soft tissues in the upward direction, palatal arch, in the direction of the pharyngeal side wall in depth. There is also extension towards the posterior wall of the hypopharynx. The tumor is now removed transorally on all sides, macroscopically complete, with a safety margin of 1 1/2 cm. Inclusion of the anterior and posterior palatal arch, tonsils including larger parts of the pharyngeal side wall, whereby the external carotid artery is visible with branches in the lower area. Resection caudal to the base of the tongue, towards the center removal of approx. 40% of the posterior hypopharyngeal wall including muscles. The tumor as a whole is thread-marked and a marginal sample of the medial right posterior hypopharyngeal wall is sent in as mucosa and soft tissue. In the frozen section, the edges of the mucosa are healthy on all sides, but there are still tumor extensions cranially, basally and in the direction of the posterior hypopharyngeal wall in the musculature. The decision was therefore made to complete the operation transcervically and cover with a flap. As flap coverage had not been expected, coverage with a platysmal flap was the most suitable solution. The patient is now repositioned for neck dissection on both sides: First start with the right side: incision in front of the sternocleidomastoid muscle in the typical manner. Exposure of the sternocleidomastoid muscle. Dissection of fat lymph node preparation. Exposure of digastric muscle, omohyoid muscle, exposure of cervical vascular sheath, internal and external jugular vein, vagus nerve, accessorius nerve and hypoglossal nerve. Development of the dorsal neck preparation while preserving the branches of the cervical plexus. Subsequent development of the anterior neck preparation, exposing and preserving the superior thyroid artery and the hypoglossal nerve. Overall evacuation level II to IV, followed by layered wound closure with insertion of a Redon drain after careful hemostasis and irrigation. The neck is now dissected on the left and the platysmal flap is elevated: the platysmal flap is marked according to the measured defect size, which is 3 x 6 cm. The platysmal flap is marked with a size of 10 x 6.5 cm, cut around and dissected along the muscle stem in the direction of the submandibular region. Attention is paid to intact venous drainage. The neck is then dissected as on the opposite side, whereby level V is also dissected, so that level II to V are dissected in total. Subsequently, a post-resection is performed under transoral and transcervical control, after exposing the internal carotid artery and looping it, as well as exposing the external carotid artery and its branches, which were located directly within the tumor resection area. The entire prevertebral musculature is removed in the area of the posterior hypopharyngeal wall. A marginal sample of the soft tissue between the mucosa and the prevertebral fascia is also taken. This is marked with a suture. Subsequently, generous resection of the soft tissues of the palatal area cranially, whereby all remaining structures of the pharyngeal side wall are removed. Only the branches of the external carotid artery, the internal carotid artery and the corresponding cranial nerves remain. Generous soft tissue is removed basally cranial to the tube as a marginal sample. There are no more carcinoma infiltrates cranially and in the basal part as well as in the soft tissue area of the posterior wall of the hypopharynx. Therefore, an R0 resection can now be assumed. Removal of the stylohyoid muscles, which was also performed as part of the resection, also created a wide tunnel to the transoral side. The platysmal flap is now pulled through this by its stalk and inserted into the defect. The flap is then sutured in place with 3/0 Vicryl single button sutures. Defect coverage is achieved easily and with little tension. Following extensive skin mobilization, irrigation, hemostasis and layered wound closure on the left side were performed, also using a Redon drain. During the operation, a tracheotomy was also performed in the typical manner. Small Kocher collar incision. Exposure of the infrahyoid musculature and splitting of the same. Exposure of the thyroid isthmus. This is passed underneath, separated and supplied with puncture ligatures. Then enter the trachea in the 2nd/3rd intercartilaginous space and create a small, wide-stemmed Björk flap. Finally, an 8/0 tracheostomy tube is inserted at the end to create a laryngectomy tube. Completion of the procedure without complications. The patient received Unacid 3 g intraoperatively several times as an intravenous antibiotic. Please continue this antibiotic treatment for one week with 3 x 1.5 g i.v. Feeding via the inserted gastric tube for approx. 10 days, then gruel and, if necessary, food build-up. A PEG was not used due to the history of gastric pull-up in esophageal carcinoma. If problems arise with platysmal flap coverage, defect coverage with radial flaps can also be performed in the interval after informing the patient. Due to the deep infiltrative growth, this is a cT2-3 oropharyngeal carcinoma. Because of the cervical lymph node status, radio therapy or even RCT should be discussed postoperatively. \ No newline at end of file diff --git a/346/InvasionFront_CD3_block1_x3_y1_patient346_0.json b/346/InvasionFront_CD3_block1_x3_y1_patient346_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8accf110fe6d9fca4a1a8af865adcd81b9ea52ee --- /dev/null +++ b/346/InvasionFront_CD3_block1_x3_y1_patient346_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11768.8, + "Centroid Y µm": 4072.8, + "Num Detections": 17792, + "Num Negative": 15655, + "Num Positive": 2137, + "Positive %": 12.01, + "Num Positive per mm^2": 935.22 + } +} \ No newline at end of file diff --git a/346/InvasionFront_CD3_block1_x4_y1_patient346_1.json b/346/InvasionFront_CD3_block1_x4_y1_patient346_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ab9a555c8c4ac19d2962d3b06477634d18514c79 --- /dev/null +++ b/346/InvasionFront_CD3_block1_x4_y1_patient346_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14367.4, + "Centroid Y µm": 4272.7, + "Num Detections": 17910, + "Num Negative": 16318, + "Num Positive": 1592, + "Positive %": 8.889, + "Num Positive per mm^2": 680.24 + } +} \ No newline at end of file diff --git a/346/InvasionFront_CD8_block1_x3_y1_patient346_0.json b/346/InvasionFront_CD8_block1_x3_y1_patient346_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad38fa7ad253f95bbe75a4c63f46770b0b7dfdfa --- /dev/null +++ b/346/InvasionFront_CD8_block1_x3_y1_patient346_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12068.6, + "Centroid Y µm": 2823.5, + "Num Detections": 18498, + "Num Negative": 16649, + "Num Positive": 1849, + "Positive %": 9.996, + "Num Positive per mm^2": 805.37 + } +} \ No newline at end of file diff --git a/346/InvasionFront_CD8_block1_x4_y1_patient346_1.json b/346/InvasionFront_CD8_block1_x4_y1_patient346_1.json new file mode 100644 index 0000000000000000000000000000000000000000..53e24a974632146809b6926f6a9d09e5909241af --- /dev/null +++ b/346/InvasionFront_CD8_block1_x4_y1_patient346_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14667.2, + "Centroid Y µm": 2973.4, + "Num Detections": 14440, + "Num Negative": 14030, + "Num Positive": 410, + "Positive %": 2.839, + "Num Positive per mm^2": 183.09 + } +} \ No newline at end of file diff --git a/346/TumorCenter_CD3_block1_x3_y2_patient346_0.json b/346/TumorCenter_CD3_block1_x3_y2_patient346_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d73fddd7ab53abb1d67ed4b8bf097fc0f105299b --- /dev/null +++ b/346/TumorCenter_CD3_block1_x3_y2_patient346_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10294.5, + "Centroid Y µm": 5522.1, + "Num Detections": 16804, + "Num Negative": 15845, + "Num Positive": 959, + "Positive %": 5.707, + "Num Positive per mm^2": 504.93 + } +} \ No newline at end of file diff --git a/346/TumorCenter_CD3_block1_x4_y2_patient346_1.json b/346/TumorCenter_CD3_block1_x4_y2_patient346_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2517e541b39260edc2892004e95d0ba7ffe700d6 --- /dev/null +++ b/346/TumorCenter_CD3_block1_x4_y2_patient346_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12793.2, + "Centroid Y µm": 5322.2, + "Num Detections": 18555, + "Num Negative": 15911, + "Num Positive": 2644, + "Positive %": 14.25, + "Num Positive per mm^2": 1260.9 + } +} \ No newline at end of file diff --git a/346/TumorCenter_CD8_block1_x3_y1_patient346_0.json b/346/TumorCenter_CD8_block1_x3_y1_patient346_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c98b8aae98f2377b7ab4639baf9a0fccd33c1ee1 --- /dev/null +++ b/346/TumorCenter_CD8_block1_x3_y1_patient346_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 11568.9, + "Num Detections": 12511, + "Num Negative": 12039, + "Num Positive": 472, + "Positive %": 3.773, + "Num Positive per mm^2": 267.93 + } +} \ No newline at end of file diff --git a/346/TumorCenter_CD8_block1_x4_y1_patient346_1.json b/346/TumorCenter_CD8_block1_x4_y1_patient346_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b93eec0c53813519e91b37647406daf014467a73 --- /dev/null +++ b/346/TumorCenter_CD8_block1_x4_y1_patient346_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 11394.0, + "Num Detections": 15864, + "Num Negative": 14999, + "Num Positive": 865, + "Positive %": 5.453, + "Num Positive per mm^2": 402.58 + } +} \ No newline at end of file diff --git a/346/history_text.txt b/346/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/346/icd_codes.txt b/346/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5e1015181d8e0c9dea59402801536068a5527137 --- /dev/null +++ b/346/icd_codes.txt @@ -0,0 +1 @@ +cT3 OrpharynxCa links[H93.1 ] Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/346/ops_codes.txt b/346/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b65b14f715a6a0f94d79c86bcbaf41927f832b08 --- /dev/null +++ b/346/ops_codes.txt @@ -0,0 +1 @@ +Temporäre Tracheotomie[5-311.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Transplantat[5-296.14 ] Entnahme eines freien Lappens am Unterarm mit mikrovaskulärer Anastomosierung[5-904.08 L] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] \ No newline at end of file diff --git a/346/patient_clinical_data.json b/346/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..662b671e2fca3099458c8f6b0e6f53ce7baf6a53 --- /dev/null +++ b/346/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 43, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/346/patient_pathological_data.json b/346/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ffed5f6c13d8d749926cfc935f275b95e9d98694 --- /dev/null +++ b/346/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "346", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 10, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/346/surgery_description.txt b/346/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ef47c5a582e667970d1873051650d43604cef269 --- /dev/null +++ b/346/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheostomy creation, Defect coverage, Free flap (Radial) diff --git a/346/surgery_report.txt b/346/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7063fa3f9462432127d13724316442948ad06dfd --- /dev/null +++ b/346/surgery_report.txt @@ -0,0 +1 @@ +After the team time-out, the patient is positioned. Injection of local anesthetic with the addition of suprarenin in the neck and sterile abjoration. First, pharyngoscopy and laryngoscopy again: the exophytic tumor is seen, which starts below the tonsil lobe or former tonsil lobe and extends towards the posterior wall of the oropharynx, the lateral wall of the oropharynx, the base of the tongue and also down towards the hypopharynx. Clear indication for surgical resection with subsequent flap coverage using a microvascular graft. Now start with the tracheostoma placement. Skin incision over approx. 4 1/2 cm below the cricoid cartilage, dissection through the platysma, search for the pretracheal muscles and insertion in the median line. Push the muscles laterally. The cricoid cartilage and the trachea can be easily palpated. Now locate the upper pole of the thyroid gland and expose it. Successive transection of the thyroid gland from cranial to caudal using a bipolar and scissors. The thyroid lobes are bluntly pushed off, the trachea is now exposed. The incision is now made between the 2nd and 3rd tracheal clasp and a Björk flap is created while protecting the tube cuff. Suturing of the Björk flap and reintubation. Subsequent skin disinfection and sterile draping of all relevant surgical areas, including the pectoralis major areas. First start with neck revision on the left: Opening of the old scar. Exposure of the sternocleidomastoid muscle. The V. jugularis externa is preserved and ligated as well as beaten caudally. Subsequent laborious dissection of the cervical vascular sheath through the scarring. The internal jugular vein can be visualized, but without any branches. Some ligatures can be visualized. The internal and external carotid arteries are then visualized. The hypoglossal artery is completely connected to the carotid artery or the bifurcation and can only be mobilized with difficulty. The facial artery and the lingual artery can be preserved from the external carotid artery and can be beaten laterally after clipping. Successive isolation of the pharyngeal tube from caudal to cranial, dissection of the large cervical vessels cranially. The styloid process is also resected cranially. During dissection, the digastric muscle is also severed and the submandibular gland is removed in the typical manner, exposing the lingual nerve and sparing the branch of the mouth, which can be exposed over a short distance. Lymph nodes are removed cranially at the parotid gland and also around the submandibular gland as well as latrally in the area of level V and laterally IV, III and II. Some lymph nodes were also removed anteriorly. Finally, complete isolation of the pharyngeal tube from the large vessels. Hypoglossal nerve preserved. Subsequently, after insertion of mouth blockers, combined removal of the tumor from the inside and outside. Tumor is removed macroscopically with a safety margin of 1.5 cm, in some cases also 1 cm. The entire side wall of the oropharynx and most of the posterior wall is removed up to the beginning of the posterior wall of the hypopharynx, which is also partially removed. At the top, lateral resection of the mucosa up to the bone at the alveolar ridge, lateral part of the tongue body or base of the tongue is also resected, including the parts of the extrinsic musculature. This is then beaten outwards and released from the piriform sinus with a wide safety margin. In the area of the larynx, it can be seen that the tumor has grown up to the edge of the vallecula or the epiglottis and has also grown up to the thyroid cartilage. Therefore, resection of the base of the tongue and vallecula, including lateral parts of the epiglottis and lateral parts of the thyroid cartilage as well as the largest parts of the arytenoid fold. Resection extends to the middle level of the piriform sinus or just to the tip of the sinus. Marginal samples are also taken from the alveolar ridge and the base of the tongue, including the epiglottis and vallecula. In addition, marginal samples from the arytenoid region up to the piriform sinus and marginal samples from the adjacent arytenoid region up to the supraglottic region are taken. The tumor is thread-marked and sent for frozen section like all other marginal samples. In the area of the aryepiglottic fold and in the area of the arytenoid region to the subglottic region still partly carcinoma in situ. Maximum moderate dysplasia in the remaining area. Due to the advanced resection in the area of the larynx, a final, approx. 0.5 to 1 cm wide mucosal resection from the arytenoid region to the piriform sinus, whereby the postcricoid region is already resected. Another 0.5 to 1 cm wide resection from the supraglottic region including the arytenoid region. The arytenoid cartilage is now exposed, as is the aryepiglottic fold lateral to the larynx or supraglottic region. Both specimens are also marked remote from the tumor and sent for final evaluation. Further resections are no longer performed due to the significant threat of inability to swallow. Subsequent irrigation of the wound area and hemostasis. Now proceed to neck dissection on the right side. Here, skin incision exactly in the pre-existing scar from the mastoid to caudal towards the jugulum. Then cut through the subcutaneous tissue and the platysma. Then skin platysmal flap formation in the cranial anterior and caudal lateral direction, including the platysma. Subsequent exposure of the anterior edge of the sternocleidomastoid muscle. Massively scarred conditions. It can now be seen that the common carotid artery with the bifurcation lies directly on the sternocleidomastoid muscle. This is now dissected. The area of the bifurcation is heavily scarred. The internal jugular vein is no longer present in the case of previous surgery. Dissection along the weakly atrophied omohyoid muscle antero-cranially to the hyoid bone. Subsequent exposure of the posterior digaster venter muscle. Subsequently, sparse fatty tissue with hardly any lymph nodes is removed. The external jugular vein is also no longer present. However, 2 stronger veins can be found and dissected in the anterior triangle of the neck. The superior thyroid artery is also dissected 3 cm long after its exit from the external carotid artery. Further vascular dissection is then performed by . Subsequent removal of the forearm flap: The size of the flap was measured beforehand. It is 11 x 8 cm and is planned three-dimensionally according to the requirements. Marking of the flap on the forearm. Curved skin incision up to the crook of the elbow. First cut the flap ulnarly. Lift the flap subfascially here. Ensure that some tissue remains on all tendons. Dissect cranially. Expose the superficial venous system, which shows a beautiful superficial vein with 2 ends in the area of the elbow. Connection to the deep venous system somewhat sparse but present. Then cut around the flap radially subfascially. Here, too, care is taken to ensure that tissue remains on the fascia. Distally, after clamping the radial artery and sufficiently long saturation over 98 to 100 %, the radial artery is removed and ligated with 4-0 prolene sutures as a through-layer ligature. The flap is then lifted along the pedicle. Small branches are clipped and bipolar coagulated. Successive tracing of the flap up to the olecranon. Here, transection of the interosseous artery after previous clamping with stable saturation. Then expose the confluence and radial artery. The vein is then removed and ligated. The artery is removed and closed with 6-0 Vascufil sutures. Flush the flap with heparin. The flap is then sutured into the defect. This is done without tension and completely except for a small remnant at the front of the tongue body. Adapting sutures are placed in the tongue body. An incision is made in the area of the larynx along the thyroid cartilage, an incision on the mucous membrane is not possible, as due to the................................. postcricoid mucosa, there is a risk of stenosis. Insertion sometimes with poor visibility and sometimes quite difficult. The stalk is now assessed with regard to connectivity. Conditioning of the radial artery and the two veins, whereby one of the cephalic veins, which is selected for the anastomosis, shows significantly thickened walls, even beyond the valve, and must be shortened. Subsequently, split skin is removed from the thigh with the dermatome, thickness approx. 0.8 mm. Starch is also applied to the wound area in the thigh and then a semi-permeable dressing is applied. Split skin is applied to the forearm without tension. Relief incision. A few swabs are sewn on to facilitate adhesion. Followed by Mepilex dressing. Wrapping with absorbent cotton and the application of some compresses. Then fitting of a Kramer splint and wrapping with an elastic bandage in a functional position. Positioning of the arm. Subsequent vascular suture. This is followed by anastomosis with the lingual and radial arteries. Suture with 8-0 Ethilon single-button sutures. Subsequent opening of the clamps, good arterial flow, good venous return. One of the cephalic veins is conditioned again for the venous anastomosis. In addition, the external jugular vein, which can be extended slightly by palpation. Here anastomosis with coupler 2.5. After opening the clamps good venous return, positive smear phenomenon. The 2nd of the cephalic veins is connected to a vein from the opposite side, which can be dissected from the submandibular gland in the sense of a facial vein and can be removed. After slight mobilization, this vein can be transferred to the left side through a tunnel that has been created and anastomosed with the second cephalic vein after appropriate conditioning using a 2.5 mm coupler. Here too, after opening the clamps, the smear phenomenon was positive. However, the pressure in the vein was slightly higher due to the lack of internal jugular vein on the right. Overall, difficult conditions as far as vessel preparation is concerned. Subsequently, the flap is well perfused. Extensive hemostasis and irrigation follows. Hemostasis of diffuse bleeding, especially on the left, is considerably more difficult and prolonged. Finally, the small diffuse bleedings were largely stopped and closed by inserting a Redon drainage and 2 flaps on the left. The forearm was primarily closed in the cranial area. Finally, insertion of a size 8 tracheostomy tube, which is fixed in the typical manner with sutures. Further inspection of the flap, which is well perfused. The procedure is completed without complications. The patient is admitted to the intensive care unit for postoperative monitoring. Please continue antibiotics for a total of 1 week. Nutrition via the PEG tube. After 12-14 days, gruel swallowing and, if necessary, diet build-up. A prolonged swallowing disorder is to be expected, in this case it is essential to plan a visit to the voice and speech department. Flap control clinically and by Doppler sonography typically for 5 days. Anticoagulation should be suspended until coagulation control, then restarted if necessary due to the diffuse bleeding tendency. Presentation at the interdisciplinary tumor conference is essential because the R situation is still uncertain; if there is still in situ carcinoma in the left laryngeal region, boost radiation should be discussed if necessary. \ No newline at end of file diff --git a/347/InvasionFront_CD3_block8_x3_y12_patient347_0.json b/347/InvasionFront_CD3_block8_x3_y12_patient347_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b81469a30f606e7157066d2396339ef64950544 --- /dev/null +++ b/347/InvasionFront_CD3_block8_x3_y12_patient347_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11419.0, + "Centroid Y µm": 40328.6, + "Num Detections": 19254, + "Num Negative": 18824, + "Num Positive": 430, + "Positive %": 2.233, + "Num Positive per mm^2": 176.6 + } +} \ No newline at end of file diff --git a/347/InvasionFront_CD3_block8_x4_y12_patient347_1.json b/347/InvasionFront_CD3_block8_x4_y12_patient347_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bab4f2704ec6bcc525e2da23419b2719c85c7513 --- /dev/null +++ b/347/InvasionFront_CD3_block8_x4_y12_patient347_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14092.5, + "Centroid Y µm": 40253.7, + "Num Detections": 23068, + "Num Negative": 22800, + "Num Positive": 268, + "Positive %": 1.162, + "Num Positive per mm^2": 107.88 + } +} \ No newline at end of file diff --git a/347/InvasionFront_CD8_block8_x3_y12_patient347_0.json b/347/InvasionFront_CD8_block8_x3_y12_patient347_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c04089992d83a7e5bab718f7a178743274e61b3e --- /dev/null +++ b/347/InvasionFront_CD8_block8_x3_y12_patient347_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10394.5, + "Centroid Y µm": 30533.8, + "Num Detections": 17795, + "Num Negative": 17649, + "Num Positive": 146, + "Positive %": 0.8205, + "Num Positive per mm^2": 59.97 + } +} \ No newline at end of file diff --git a/347/InvasionFront_CD8_block8_x4_y12_patient347_1.json b/347/InvasionFront_CD8_block8_x4_y12_patient347_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2a1233292507791b5080ea6e734569d97282460e --- /dev/null +++ b/347/InvasionFront_CD8_block8_x4_y12_patient347_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13143.0, + "Centroid Y µm": 30708.7, + "Num Detections": 21260, + "Num Negative": 21141, + "Num Positive": 119, + "Positive %": 0.5597, + "Num Positive per mm^2": 47.76 + } +} \ No newline at end of file diff --git a/347/TumorCenter_CD3_block8_x3_y12_patient347_0.json b/347/TumorCenter_CD3_block8_x3_y12_patient347_0.json new file mode 100644 index 0000000000000000000000000000000000000000..85187149b676bac29c4c3609cfc3b27807b41175 --- /dev/null +++ b/347/TumorCenter_CD3_block8_x3_y12_patient347_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 31458.3, + "Num Detections": 15445, + "Num Negative": 14896, + "Num Positive": 549, + "Positive %": 3.555, + "Num Positive per mm^2": 247.39 + } +} \ No newline at end of file diff --git a/347/TumorCenter_CD3_block8_x4_y12_patient347_1.json b/347/TumorCenter_CD3_block8_x4_y12_patient347_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d58cdada5baadde1701ecc3d2f7670f93ba154ee --- /dev/null +++ b/347/TumorCenter_CD3_block8_x4_y12_patient347_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 31258.4, + "Num Detections": 16925, + "Num Negative": 16125, + "Num Positive": 800, + "Positive %": 4.727, + "Num Positive per mm^2": 358.5 + } +} \ No newline at end of file diff --git a/347/TumorCenter_CD8_block8_x3_y12_patient347_0.json b/347/TumorCenter_CD8_block8_x3_y12_patient347_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f60a5b3e7366275ee855a8f7463bcf2ecb44cf33 --- /dev/null +++ b/347/TumorCenter_CD8_block8_x3_y12_patient347_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12593.3, + "Centroid Y µm": 30209.0, + "Num Detections": 21388, + "Num Negative": 21144, + "Num Positive": 244, + "Positive %": 1.141, + "Num Positive per mm^2": 102.59 + } +} \ No newline at end of file diff --git a/347/TumorCenter_CD8_block8_x4_y12_patient347_1.json b/347/TumorCenter_CD8_block8_x4_y12_patient347_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0b3d22cbb758e1f2665f833daac5b43cba268abd --- /dev/null +++ b/347/TumorCenter_CD8_block8_x4_y12_patient347_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15092.0, + "Centroid Y µm": 30109.1, + "Num Detections": 23272, + "Num Negative": 23162, + "Num Positive": 110, + "Positive %": 0.4727, + "Num Positive per mm^2": 45.03 + } +} \ No newline at end of file diff --git a/347/history_text.txt b/347/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/347/icd_codes.txt b/347/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ee2395ae42d588ecefc03b8ea461e0a9a6da7ff1 --- /dev/null +++ b/347/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx Seitenwand[C10.2 ] \ No newline at end of file diff --git a/347/ops_codes.txt b/347/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..72f54f5d96ab7d5ab7b5c7976dde600535e2c60c --- /dev/null +++ b/347/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Partielle Exzision [erkrankter] harter und weicher Gaumen[5-272.1 ] Elektrokoagulation harter und weicher Gaumen[5-272.60 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.01 ] \ No newline at end of file diff --git a/347/patient_clinical_data.json b/347/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..89e96ba2fe6f4696b88a70357585af5f8ebb6cb0 --- /dev/null +++ b/347/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/347/patient_pathological_data.json b/347/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ef202a827feaeb1262024abd1f40ddc559c90e85 --- /dev/null +++ b/347/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "347", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/347/surgery_description.txt b/347/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb585cf440f8be16613ac412188be40d88cfd104 --- /dev/null +++ b/347/surgery_description.txt @@ -0,0 +1 @@ +TORS procedure diff --git a/347/surgery_report.txt b/347/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6452bebd4bf2cb40a8710d9492482eb2cb7981ba --- /dev/null +++ b/347/surgery_report.txt @@ -0,0 +1 @@ +After induction of intubation anesthesia, a second panendoscopy is performed. This reveals an exophytic tumor that infiltrates parauvularly from the anterior palatal arch into the tonsil, where it reaches close to the last molar and from there merges into the glossoalveolar groove. From there it infiltrates further into the base of the tongue and the upper edge of the hypopharynx. In the CT scan, it does not appear to be a strong tumor extension towards the vascular sheath, but rather a largely superficial growth. After extensive inspection, the possibility of resection using TORS is confirmed with overall good adjustability and good mouth opening of the patient. Insertion of the mouth retractor and good exposure of the tumor. After docking the patient cart of the robot, insertion of the instruments. Maryland forceps are used on the left and a monopolar spatula with a diameter of 8 mm is used on the right. First mark the resection margins using the monopolar spatula. The incision begins parauvularly. The resection is performed successively with a safety margin of about 5-10 mm in the extension described above. Part of the posterior palatal arch can be preserved so that the patient can swallow without regurgitation. The resectate can be removed en bloc together with the part of the base of the tongue and the orohypoharyngeal junction. The resection is carried out laterally into the parapharyngeal fatty tissue. The vessels of the cervical vascular sheath remain well covered by tissue. Overall, no major bleeding during the entire course of the operation. After the tumor is removed en bloc, first meticulous hemostasis. Careful inspection of the specimen. The tumor appears macroscopically distant from the healthy tissue. Therefore, marginal samples are now taken from the tumor specimen. These are sent in for frozen section diagnostics and assessed intraoperatively as tumor-free by the pathologist. This therefore appears to be an R0 resection of the specimen. The tumor specimen is thread-marked for final histopathological evaluation. Another intensive intraoperative check of the findings. Due to the exposed parapharyngeal fatty tissue, it is decided to perform the neck dissection on both sides in order to prevent fistula formation. Due to the fact that the patient was very easy to intubate and there was no serious bleeding during the entire course of the operation, it was decided not to perform a tracheostomy on the patient for the time being. Instead, the patient should be monitored in the intensive care unit for at least 3-4 days postoperatively. Subsequently, planning of neck dissection on both sides and, if necessary, adjuvant therapy in the tumor conference. \ No newline at end of file diff --git a/348/InvasionFront_CD3_block19_x1_y1_patient348_0.json b/348/InvasionFront_CD3_block19_x1_y1_patient348_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1b657fddcc67dd08ce319640ec902a1479740267 --- /dev/null +++ b/348/InvasionFront_CD3_block19_x1_y1_patient348_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 4647.5, + "Num Detections": 17085, + "Num Negative": 15057, + "Num Positive": 2028, + "Positive %": 11.87, + "Num Positive per mm^2": 874.01 + } +} \ No newline at end of file diff --git a/348/InvasionFront_CD3_block19_x2_y1_patient348_1.json b/348/InvasionFront_CD3_block19_x2_y1_patient348_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e187ac5eefd683e7cd5e828316baa917c362db2c --- /dev/null +++ b/348/InvasionFront_CD3_block19_x2_y1_patient348_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8345.6, + "Centroid Y µm": 4872.4, + "Num Detections": 16994, + "Num Negative": 16320, + "Num Positive": 674, + "Positive %": 3.966, + "Num Positive per mm^2": 292.39 + } +} \ No newline at end of file diff --git a/348/InvasionFront_CD8_block19_x1_y1_patient348_0.json b/348/InvasionFront_CD8_block19_x1_y1_patient348_0.json new file mode 100644 index 0000000000000000000000000000000000000000..38ca47d5257279f8c20f37a45c120eba8d0639e5 --- /dev/null +++ b/348/InvasionFront_CD8_block19_x1_y1_patient348_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4797.5, + "Centroid Y µm": 12250.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/348/InvasionFront_CD8_block19_x2_y1_patient348_1.json b/348/InvasionFront_CD8_block19_x2_y1_patient348_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1197761d3bee7ea5b98f5e8307f98a73236c0f03 --- /dev/null +++ b/348/InvasionFront_CD8_block19_x2_y1_patient348_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7346.1, + "Centroid Y µm": 12400.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/348/TumorCenter_CD3_block19_x1_y1_patient348_0.json b/348/TumorCenter_CD3_block19_x1_y1_patient348_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9e641d0ba82a7be479c7e04384db95529d45ed86 --- /dev/null +++ b/348/TumorCenter_CD3_block19_x1_y1_patient348_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 4997.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/348/TumorCenter_CD3_block19_x2_y1_patient348_1.json b/348/TumorCenter_CD3_block19_x2_y1_patient348_1.json new file mode 100644 index 0000000000000000000000000000000000000000..95f94dbb97051f0e375ab2586991cb971dc6e59e --- /dev/null +++ b/348/TumorCenter_CD3_block19_x2_y1_patient348_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5647.0, + "Centroid Y µm": 4598.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/348/TumorCenter_CD8_block19_x1_y1_patient348_0.json b/348/TumorCenter_CD8_block19_x1_y1_patient348_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cdfc2c757927894fa8559e25d4e812ed640f1ea6 --- /dev/null +++ b/348/TumorCenter_CD8_block19_x1_y1_patient348_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 13600.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/348/TumorCenter_CD8_block19_x2_y1_patient348_1.json b/348/TumorCenter_CD8_block19_x2_y1_patient348_1.json new file mode 100644 index 0000000000000000000000000000000000000000..590b101d45808d83db760f690dd29f3d4b6e0ea7 --- /dev/null +++ b/348/TumorCenter_CD8_block19_x2_y1_patient348_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9020.2, + "Centroid Y µm": 13635.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/348/history_text.txt b/348/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb2527e34e81fe2c072b7c6adf4503e2f7d01cd2 --- /dev/null +++ b/348/history_text.txt @@ -0,0 +1 @@ +The patient has a history of an externally histologically confirmed lymphoepithelial carcinoma of the left tonsil cT2 cN2b. After a detailed discussion with the patient, the above measures were indicated. \ No newline at end of file diff --git a/348/icd_codes.txt b/348/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0d0f4db307b38887294336b756e439993e2ec53 --- /dev/null +++ b/348/icd_codes.txt @@ -0,0 +1 @@ +Oropharynxkarzinom[C10.9 ] \ No newline at end of file diff --git a/348/ops_codes.txt b/348/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ecdcc51f017850e72f3ee4af3f107889c9cdcb8 --- /dev/null +++ b/348/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Perkutane [endoskopische] Gastrostomie [PEG][5-431.2 ] Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 R] \ No newline at end of file diff --git a/348/patient_clinical_data.json b/348/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f9bf768ea93b610ccc4086b362d274d1a052befc --- /dev/null +++ b/348/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 37, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/348/patient_pathological_data.json b/348/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0259912d1a622da3e101351e3f370d5d06b981b9 --- /dev/null +++ b/348/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "348", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Lymphoepithelial", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/348/surgery_description.txt b/348/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2a2a2d3a3e66cad2bd5cc369c9051e61ce19fa3f --- /dev/null +++ b/348/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Bilateral neck dissection, PEG placement diff --git a/348/surgery_report.txt b/348/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a67240491774b8bcdb9b33b2b27d1ddc70d62c5 --- /dev/null +++ b/348/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, first perform a rigid tracheoscopy using O° optics. Inconspicuous mucosal conditions in the area of the trachea up to the carina. The surgeon then performs transnasal and tracheal intubation and positioning of the patient without any problems. Perform a laryngo- and pharyngoscopy using a Kleinsasser tube. The glottis, the supraglottis, the posterior hypopharyngeal wall, the postcricoid region and the piriform sinuses on both sides were unremarkable. The posterior wall of the oropharynx and the right lateral wall were unremarkable. In the area of the left tonsillar lobe, there was an approx. 3 x 2 cm large contact volnerable mass covered with uneven mucosa, occupying the entire tonsillar lobe and a part of the posterior palatine arch, the anterior palatine arch and the palate ....Somit insertion of the oral cavity with the tonsillar retractor. Make an incision cranial to the mass close to the uvula and carefully cut around the mass to perform a transoral tumor tonsillectomy. Targeted, careful hemostasis using bipolar coagulation. Removal of the specimen in toto, which is sent in thread-marked for final histology (short short cranial uvula, short long wound base middle third, long long tongue base caudal), macroscopic clear impression of a complete resection. Three marginal samples were taken (cranial uvula, middle third of the wound bed, caudal towards the base of the tongue), which were sent for intraoperative frozen section examination and found to be free of tumor and dysplasia. This results in an R0 situation (in the frozen section). Repeated inspection and hemostasis using bipolar coagulation. Relaxation of the retractor. Re-inspection of the tonsil lobe on the left side and completion of the tumor tonsillectomy under dry conditions. Subsequent skin spray disinfection on both sides of the neck. Infiltration anesthesia, abjoration of the skin and sterile draping. Start neck dissection on the right side. Make an incision along the anterior border of the sternocleidomastoid muscle, cut through the subcutaneous tissue and expose the platysma. Dissection of the platysma, exposure of the anterior border of the sternocleidomastoid muscle, exposure of the accessorius nerve, exposure of the digastric muscle and the omohyoid muscle. Dissection along the internal jugular vein. Dissection of the cervical vascular sheath. 3 enlarged lymph nodes are carefully removed in toto in the area of region 2a. Subsequent removal of the posterior neck specimen. Hemostasis using bipolar coagulation, protection of the plexus branches. Subsequent removal of the anterior neck specimen. The hypoglossal nerve and the cervical sinus were exposed and spared. Hemostasis using bipolar coagulation. Placement of a 10-gauge Redon drainage, two-layer wound closure. Application of a pressure bandage and repositioning of the patient for a modified radical neck dissection on the left side type III. Application of an incision along the anterior edge of the sternocleidomastoid muscle. Dissection of the subcutaneous tissue, dissection of the platysma, exposure of the anterior margin of the sternocleidomastoid muscle; during the dissection of the posterior surface of the sternocleidomastoid muscle, the space-occupying lesions described in the preoperative sonography, which are suspected metastases, are not touched. Exposure of the N. accessorius and the M. omohyoideus. Dissection along the internal jugular vein from caudal to cranial. The above-described masses can be pushed off very well from the internal jugular vein, the accessory nerve and the sternocleidomastoid muscle and are extirpated in toto. Exposure of the hypoglossal nerve and digaster muscle. Removal of the posterior neck specimen while sparing the plexus branches, removal of the anterior neck specimen while sparing the cervical anlage. Hemostasis using bipolar coagulation. Demonstration of findings on , placement of a 10-gauge Redon drainage, two-layer wound closure. Completion of the procedure without complications. Conclusion: Panendoscopy with PEG placement, transoral tumor tonsillectomy, modified radical neck dissection type III on the left side and selective neck dissection region II and III on the right side. The intraoperative frozen section examination revealed an R0 situation. After consultation with , a tracheotomy was deliberately avoided. Waiting for the final histology, cervical suture removal on both sides on the 8th postoperative day and presentation of the patient in our interdisciplinary tumor conference planned for planning adjuvant therapy. \ No newline at end of file diff --git a/349/InvasionFront_CD3_block10_x5_y6_patient349_0.json b/349/InvasionFront_CD3_block10_x5_y6_patient349_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7abb59dd3fba676aaedafaeba78d3a49ea520dfa --- /dev/null +++ b/349/InvasionFront_CD3_block10_x5_y6_patient349_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 20963.9, + "Num Detections": 21158, + "Num Negative": 20072, + "Num Positive": 1086, + "Positive %": 5.133, + "Num Positive per mm^2": 445.73 + } +} \ No newline at end of file diff --git a/349/InvasionFront_CD3_block10_x6_y6_patient349_1.json b/349/InvasionFront_CD3_block10_x6_y6_patient349_1.json new file mode 100644 index 0000000000000000000000000000000000000000..61571e7f32fb39f8628065c1e5032ea680dbb318 --- /dev/null +++ b/349/InvasionFront_CD3_block10_x6_y6_patient349_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20957.3, + "Centroid Y µm": 21413.9, + "Num Detections": 18691, + "Num Negative": 17837, + "Num Positive": 854, + "Positive %": 4.569, + "Num Positive per mm^2": 357.43 + } +} \ No newline at end of file diff --git a/349/InvasionFront_CD8_block10_x5_y6_patient349_0.json b/349/InvasionFront_CD8_block10_x5_y6_patient349_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4c4243819425124def58070c7b5903129d1c803c --- /dev/null +++ b/349/InvasionFront_CD8_block10_x5_y6_patient349_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17840.6, + "Centroid Y µm": 20963.9, + "Num Detections": 21790, + "Num Negative": 21056, + "Num Positive": 734, + "Positive %": 3.369, + "Num Positive per mm^2": 306.47 + } +} \ No newline at end of file diff --git a/349/InvasionFront_CD8_block10_x6_y6_patient349_1.json b/349/InvasionFront_CD8_block10_x6_y6_patient349_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f21e90f4b5cb3077baa5a22472555b339007b7d8 --- /dev/null +++ b/349/InvasionFront_CD8_block10_x6_y6_patient349_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20514.1, + "Centroid Y µm": 21163.8, + "Num Detections": 19564, + "Num Negative": 19010, + "Num Positive": 554, + "Positive %": 2.832, + "Num Positive per mm^2": 229.11 + } +} \ No newline at end of file diff --git a/349/TumorCenter_CD3_block10_x5_y6_patient349_0.json b/349/TumorCenter_CD3_block10_x5_y6_patient349_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c87cca8309391dd398a7cc336f7944b1448a63c9 --- /dev/null +++ b/349/TumorCenter_CD3_block10_x5_y6_patient349_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 14817.2, + "Num Detections": 18222, + "Num Negative": 17152, + "Num Positive": 1070, + "Positive %": 5.872, + "Num Positive per mm^2": 541.43 + } +} \ No newline at end of file diff --git a/349/TumorCenter_CD3_block10_x6_y6_patient349_1.json b/349/TumorCenter_CD3_block10_x6_y6_patient349_1.json new file mode 100644 index 0000000000000000000000000000000000000000..959731ff41c2c8df508d54bad5e83c55087d50fc --- /dev/null +++ b/349/TumorCenter_CD3_block10_x6_y6_patient349_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21638.5, + "Centroid Y µm": 14792.2, + "Num Detections": 21716, + "Num Negative": 21411, + "Num Positive": 305, + "Positive %": 1.404, + "Num Positive per mm^2": 119.56 + } +} \ No newline at end of file diff --git a/349/TumorCenter_CD8_block10_x5_y6_patient349_0.json b/349/TumorCenter_CD8_block10_x5_y6_patient349_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7313c5894bf94053e39debad11d441664b6c9c18 --- /dev/null +++ b/349/TumorCenter_CD8_block10_x5_y6_patient349_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 15316.9, + "Num Detections": 20393, + "Num Negative": 19631, + "Num Positive": 762, + "Positive %": 3.737, + "Num Positive per mm^2": 347.56 + } +} \ No newline at end of file diff --git a/349/TumorCenter_CD8_block10_x6_y6_patient349_1.json b/349/TumorCenter_CD8_block10_x6_y6_patient349_1.json new file mode 100644 index 0000000000000000000000000000000000000000..da15a3ee880e2068ab0e77c8a94a530a4e2e2217 --- /dev/null +++ b/349/TumorCenter_CD8_block10_x6_y6_patient349_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 15241.9, + "Num Detections": 23635, + "Num Negative": 22802, + "Num Positive": 833, + "Positive %": 3.524, + "Num Positive per mm^2": 312.97 + } +} \ No newline at end of file diff --git a/349/history_text.txt b/349/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b4cb5b8a667bb051f6ac03e84966119a1ec9a71d --- /dev/null +++ b/349/history_text.txt @@ -0,0 +1 @@ +A cT2 cN2b G3 uvular carcinoma was histologically confirmed in the patient during a panendoscopy on <2013>. In our interdisciplinary tumor conference, primary surgical treatment was recommended. Even with promptly planned surgical treatment, a cN3 neck status with an indistinguishable internal carotid artery was found preoperatively, but CT showed intact conditions here. No evidence of distant metastasis. \ No newline at end of file diff --git a/349/icd_codes.txt b/349/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5c4857dc0a87026cb8e1118e6658619d973cba42 --- /dev/null +++ b/349/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Uvula[C05.2 ] \ No newline at end of file diff --git a/349/ops_codes.txt b/349/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..06ea0bd56512427ad2aef23ad054cb9622475d6b --- /dev/null +++ b/349/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Anlage eines Systems zur Vakuumversiegelung an Haut und Unterhaut[5-916.a0 ] Kontinuierliche Sogbehandlung mit Pumpensystem bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.20 ] Entnahme freier Radialis-Lappen[5-858.23 L] Vollhaut Entnahmestelle Leisten- und Genitalregion[5-901.1c ] \ No newline at end of file diff --git a/349/patient_clinical_data.json b/349/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0b940deb90a503ea5ddeb7b29a2b0fc7f6f6d48f --- /dev/null +++ b/349/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 16, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/349/patient_pathological_data.json b/349/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a1583ab958723508bc6d7ea0f0fcfa3a1783c92b --- /dev/null +++ b/349/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "349", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/349/surgery_description.txt b/349/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..32ce804694ed790369b83c0bdfb1b64eb1ee475e --- /dev/null +++ b/349/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Defect coverage, Free flap (Radial), Bilateral neck dissection, PEG placement diff --git a/349/surgery_report.txt b/349/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ca4dc24d456d3e27a1be7fa9891f1a125ffa9102 --- /dev/null +++ b/349/surgery_report.txt @@ -0,0 +1 @@ +After preparation and intubation by the anesthesia colleagues, a pharyngoscopy was performed and the extent of the tumor was checked again. An exophytic tumor was found in the area of the uvula with markedly uneven mucosal extensions towards the soft palate and the tonsillar lobes on both sides. Overall, however, the tumor is somewhat left-sided. The tonsils themselves are inconspicuous and free, no significant deep growth. Submucosal growth was ruled out, so that the tumor was initially resected en bloc with a safety margin of a good 1.5 cm. After safe complete resection, the tumor is resected with tonsillectomy on both sides. Left Performing a tumor tonsillectomy with removal of the anterior palatal arch on the right side. Classic tonsillectomy using the dissection technique, providing a good overview of the posterior palatal arch and the posterior surface of the soft palate. Resection macroscopically far in sano with subtotal removal of the soft palate, the tumor is also completely resected in sano on the specimen. Now removal of completely covering margin samples. The invasive carcinoma is resected in sano, but in the area of the posterior surface of the soft palate, with a macroscopic safety margin of approx. 2 cm, there is discontinuous Cis at the edge of the deposit, so a complete resection is performed here as well as the removal of an additional covering margin sample, which shows no higher-grade dysplasia or Cis, so that the final situation is R0. After measuring the defect, the patient is turned to PEG placement. The gastroscope is inserted under laryngoscopic control into the stomach without any problems, here with excellent diaphanoscopy, the stomach is punctured without any problems and the PEG tube is inserted using the usual thread pull-through method. The patient is then repositioned. Injection of xylocaine with adrenaline in the neck area. Initially, due to the extensive soft tissue infiltration and infiltration of the internal jugular vein on the left, turn to neck dissection on the right to secure the vascular status. Curved skin incision on the anterior edge of the sternocleidomastoid muscle. Separation of skin and subcutaneous tissue. Exposure and transection of the platysma. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digastric muscle. Removal of the anterior neck preparation with careful protection and preservation of the strong facial vein, the extremely slender superior thyroid artery and the hypoglossal nerve with cervical anus. Free preparation of the internal jugular vein. Exposure of the accessorius nerve, clearing of the accessorius triangle with careful protection of the nerve. Subsequent evacuation of level Va with careful protection of the cervical plexus branches, here macroscopically no suspicious nodules overall so that after wound irrigation the procedure is moved to the opposite side. Here, with infiltration of the directly subcutaneously located metastasis of the caudal parotid gland, the incision is curved around the lobule in the direction of the mastoid and then diverted cervically. Cut through the skin and subcutaneous tissue, preserving the platysma caudally. Exposure of the sternocleidomastoid muscle and the omohyoid muscle. Anterior exposure of the submandibular gland and the digastric muscle, which is clearly infiltrated in the area of the posterior venter. Release of the lobule, dissection down to the mastoid, the mass infiltrates the sternocleidomastoid muscle over a wide area directly into the subcutaneous level, here infraauricularly thin conditions, so that cloudy secretion is discharged at points when attempting to dissect the skin, therefore leaving the entire skin area, here above the metastasis en bloc resection, here of a spindle of 2 x 2.5 cm and thus complete coverage, otherwise no skin infiltration. Dissection of the soft tissue mantle. After visualization of the cervical vascular sheath caudally and safe infiltration of the sternocleidomastoid muscle and the internal jugular vein, the muscle and vein were removed. Careful protection of the common carotid artery and the vagus nerve. Cranial dissection first of level V. Numerous nodules here, additionally here also circumscribed black pigmented changes, corresponding to the aspect of melanin changes, complete removal. Caudal preservation of the cervical plexus. Complete cranial resection. Here, the mass is broadly overlying and infiltrating the paravertebral musculature. Extremely aggressive perinodal growth. Complete resection of the paravertebral musculature. Exposure of the carotid bulb and the hypoglossal nerve, which can be preserved. Clearly no infiltration. Infiltration of the branches of the external carotid artery, here the occipital artery, the facial artery. Separation of the vessels, otherwise no carotid infiltration. Cranial complete rupture of the jugular-facial angle, the vein can only be deposited in a healthy state just below the base of the skull, here treatment with ligature and puncture. Infiltration of the sternocleidomastoid muscle as far as the mastoid, therefore the periosteum is completely taken away. Bone infiltration. Infiltration of the caudal parotid gland, here showing the marginal mandibular nerve, which can just be detached from the mass without infiltration drawings. Otherwise no growth towards the facial nerve trunk. Mobilization of the non-infiltrated submandibular gland and complete evacuation of level Ib while leaving the gland intact and removal of the metastasis en bloc in toto with macroscopic in sano resection. Subsequently, careful treatment of the detached vessels, wound irrigation with H202 and Ringer's solution and insertion of two 10-gauge Redon drains as well as careful two-layer wound closure and circumscribed execution of relief incisions to close the current defect. The radialis graft is then removed from the left forearm. Marking of the graft, measuring a total of 11.5 x 5.5 cm with a special configuration for the soft palate and tonsil lobe. Creation of the tourniquet. Cutting around the graft. Widening of the skin incision towards the crook of the elbow. Initial radial dissection. Exposure of the cephalic vein, which is taken along the lateral edge of the graft. Identification and careful protection of the radial superfacial nerve ramus. Exposure of the distal vascular pedicle, ligation of the distal vascular pedicle. Free preparation of the brachioradialis muscle, followed by ulnar preparation. Exposure of the flexor carpi ulnaris muscle. Strictly subfacial release of the graft, proximal pedicle preparation including the cephalic vein. Exposure of a strong venous vascular bridge between the deep venous system and the strong cephalic vein. Exposure of the radial artery after securing the outlet of the ulnar artery. Subsequent reopening of the blood vessel with vital margins and vital graft. Careful hemostasis and removal of the graft. After careful hemostasis, the wound is closed in two layers and the full-thickness skin graft harvested from the right groin is implanted. The vacuum pump is then applied and the Cramer splint is placed in the functional site. Full-thickness skin harvesting from the right groin: For this purpose, incision of an area measuring approx. 12 x 5 cm, strictly cutaneous elevation. Subcutaneous mobilization, careful hemostasis and, after insertion of a 10 mm Redon drainage, careful multi-layer wound closure under moderate tension. The graft is then implanted after the right-sided pharyngotomy has been performed. This involved resection of the posterior digastric muscle. The pharyngotomy is performed transorally and transcervically. Widening of the pharyngotomy with as little muscle resection as possible. Creation of a 2.15 finger-wide tunnel. Insertion of the graft, successive suturing. This succeeds well and adequately with a good fit and complete coverage of the pharyngotomy. The graft vessels are then conditioned. The arterial vessels are then explored. Here, the arterial vessels on the right side are extremely narrow and calibrated. Proximal preparation of the facial artery, here somewhat stronger conditions. Due to the position, the arterial anastomosis is now performed with 8.0 Ethilon under significantly more difficult suturing conditions. Overall laborious adaptation, but finally sufficient anastomosis with immediate venous return. Conditioning of the facial vein and implementation of the venous anastomosis using the coupler system with a coupler size 4.0. Subsequent regular pedicle pulsation. Positive spreading phenomenon and vital graft enorally, so that after final wound inspection on the right cervical side, a 10-gauge Redon drain was inserted, followed by careful two-layer wound closure and completion of the procedure with a vital graft without any indication of complications. Note: The patient received intraoperative intravenous antibiotics with Unacid 3 g, which should be continued for 24 hours postoperatively. Conclusion: Intraoperative R0 resected cT2 cN3 left-sided uvular carcinoma, extended radical neck dissection with subtotal removal of the cervical plexus and paravertebral musculature. Postoperative careful flap monitoring with vital conditions and regular enoral healing, gradual food intake can be started from the 7th postoperative day. A tracheotomy was deliberately avoided in the case of completely thin enoral conditions and no exposed wound surface. If the wound heals properly, prompt presentation for planning the absolutely necessary adjuvant therapy in the case of extremely aggressive and rapidly progressive cervical metastasis. \ No newline at end of file diff --git a/350/InvasionFront_CD3_block10_x3_y10_patient350_0.json b/350/InvasionFront_CD3_block10_x3_y10_patient350_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7ee25b659b5157006a1749d565ebc2af31c93dd9 --- /dev/null +++ b/350/InvasionFront_CD3_block10_x3_y10_patient350_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11943.7, + "Centroid Y µm": 31058.6, + "Num Detections": 24352, + "Num Negative": 16101, + "Num Positive": 8251, + "Positive %": 33.88, + "Num Positive per mm^2": 3360.8 + } +} \ No newline at end of file diff --git a/350/InvasionFront_CD3_block10_x4_y10_patient350_1.json b/350/InvasionFront_CD3_block10_x4_y10_patient350_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0f3c21083edfd06bd734d34ccc65483379974c65 --- /dev/null +++ b/350/InvasionFront_CD3_block10_x4_y10_patient350_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14467.3, + "Centroid Y µm": 31333.4, + "Num Detections": 24953, + "Num Negative": 17182, + "Num Positive": 7771, + "Positive %": 31.14, + "Num Positive per mm^2": 3040.6 + } +} \ No newline at end of file diff --git a/350/InvasionFront_CD8_block10_x3_y10_patient350_0.json b/350/InvasionFront_CD8_block10_x3_y10_patient350_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7521f242339515dfcf1b8bd25569bf6e6ab7dac3 --- /dev/null +++ b/350/InvasionFront_CD8_block10_x3_y10_patient350_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12468.4, + "Centroid Y µm": 31633.3, + "Num Detections": 24456, + "Num Negative": 19170, + "Num Positive": 5286, + "Positive %": 21.61, + "Num Positive per mm^2": 2124.8 + } +} \ No newline at end of file diff --git a/350/InvasionFront_CD8_block10_x4_y10_patient350_1.json b/350/InvasionFront_CD8_block10_x4_y10_patient350_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f44c9a052e2725eb87a45b56f4cba7da41f66fe5 --- /dev/null +++ b/350/InvasionFront_CD8_block10_x4_y10_patient350_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14992.1, + "Centroid Y µm": 31608.3, + "Num Detections": 25969, + "Num Negative": 20407, + "Num Positive": 5562, + "Positive %": 21.42, + "Num Positive per mm^2": 2138.6 + } +} \ No newline at end of file diff --git a/350/TumorCenter_CD3_block10_x3_y10_patient350_0.json b/350/TumorCenter_CD3_block10_x3_y10_patient350_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42814af4dd05400b4eae60709f839cffc73bdc2f --- /dev/null +++ b/350/TumorCenter_CD3_block10_x3_y10_patient350_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13967.6, + "Centroid Y µm": 24736.9, + "Num Detections": 25919, + "Num Negative": 17677, + "Num Positive": 8242, + "Positive %": 31.8, + "Num Positive per mm^2": 3209.3 + } +} \ No newline at end of file diff --git a/350/TumorCenter_CD3_block10_x4_y10_patient350_1.json b/350/TumorCenter_CD3_block10_x4_y10_patient350_1.json new file mode 100644 index 0000000000000000000000000000000000000000..85d70a489383010bd3f6166cf50b89db9150963d --- /dev/null +++ b/350/TumorCenter_CD3_block10_x4_y10_patient350_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 24612.0, + "Num Detections": 26247, + "Num Negative": 17349, + "Num Positive": 8898, + "Positive %": 33.9, + "Num Positive per mm^2": 3465.6 + } +} \ No newline at end of file diff --git a/350/TumorCenter_CD8_block10_x3_y10_patient350_0.json b/350/TumorCenter_CD8_block10_x3_y10_patient350_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7b8d3beefa5dfc11b272f4775c5bd2a19c044579 --- /dev/null +++ b/350/TumorCenter_CD8_block10_x3_y10_patient350_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11568.9, + "Centroid Y µm": 25611.4, + "Num Detections": 23906, + "Num Negative": 17114, + "Num Positive": 6792, + "Positive %": 28.41, + "Num Positive per mm^2": 2622.7 + } +} \ No newline at end of file diff --git a/350/TumorCenter_CD8_block10_x4_y10_patient350_1.json b/350/TumorCenter_CD8_block10_x4_y10_patient350_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c24c213b195c834e02d0cffc448288f4223ba7cb --- /dev/null +++ b/350/TumorCenter_CD8_block10_x4_y10_patient350_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 25411.5, + "Num Detections": 24394, + "Num Negative": 13923, + "Num Positive": 10471, + "Positive %": 42.92, + "Num Positive per mm^2": 3964.3 + } +} \ No newline at end of file diff --git a/350/history_text.txt b/350/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..116b66657461de9f3ec3779ac939f4598c88c433 --- /dev/null +++ b/350/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Enlarged lymph nodes in the area of the left neck with a tumor-suspicious area in the area of the left tonsil. Indication for panendoscopy and tumor tonsillectomy on the left for histological confirmation and, if necessary, tumor resection. \ No newline at end of file diff --git a/350/icd_codes.txt b/350/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/350/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/350/ops_codes.txt b/350/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..551d3504fb8c90b8de7997bed472709ce36047fc --- /dev/null +++ b/350/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Transorale Tumortonsillektomie[5-281.2 ] \ No newline at end of file diff --git a/350/patient_clinical_data.json b/350/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1eed9f65576f1bb4aa21ab9150af2007e734d590 --- /dev/null +++ b/350/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/350/patient_pathological_data.json b/350/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f4e02f34adac488fac03121d7feac3e851a33876 --- /dev/null +++ b/350/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "350", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Lymphoepithelial", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/350/surgery_description.txt b/350/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..50515d2a607fad414459119388f75fb2a3bd3681 --- /dev/null +++ b/350/surgery_description.txt @@ -0,0 +1 @@ +Tumor-tonsillectomy on the left, Panendoscopy diff --git a/350/surgery_report.txt b/350/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b6396ecdbbbf7d62600569b02c5b84d51003bb97 --- /dev/null +++ b/350/surgery_report.txt @@ -0,0 +1 @@ +First consultation with the anesthetist. Then advance the 0° telescope through the glottic plane into the trachea. This is extremely difficult because it is very difficult to adjust the patient. Inconspicuous mucosal conditions in the area of the trachea and in the area of the bronchial system up to the exit of the segmental bronchi. Intubation of the patient by using the glide laryngoscope. First inspect the postcricoid region and the hypopharynx on both sides: the mucosal conditions here are unremarkable. Now inspect the base of the tongue. No abnormalities here either. Inspection of the oropharynx reveals a clearly enlarged left tonsil with suspicious areas, with unremarkable findings in the area of the right tonsil. Pulling up the soft palate and inspection of the nasopharynx: Inconspicuous mucosal conditions here. Now advance the flexible oesophagoscope into the stomach. The mucosal conditions in the stomach and oesophagus are also normal. As discussed with the patient before the operation, the left tonsil is now removed as a tumor tonsillectomy. As far as can be assessed intraoperatively, the resection is successful in healthy tissue. The specimen is sent in its entirety for frozen section diagnostics. This reveals a circumscribed R1 resection in the area of the caudal margin. As a result, resection and collection of marginal samples, which are again found to be tumor-free during frozen section diagnostics. As part of the tumor tonsillectomy, the left tonsil and parts of the base of the tongue were resected. At the end of the operation, a mucosoplasty was performed in the area of the caudal margin to avoid scarring. After careful hemostasis, the procedure was completed. Depending on the p16 .......................... findings of the preparation, further procedure. Final discussion with the anesthesia department in the form of a consultation. The patient is transferred to the recovery ward. \ No newline at end of file diff --git a/351/InvasionFront_CD3_block17_x1_y10_patient351_0.json b/351/InvasionFront_CD3_block17_x1_y10_patient351_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e6e2e36846a1d715f37309fe874bb3e861b6028f --- /dev/null +++ b/351/InvasionFront_CD3_block17_x1_y10_patient351_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3373.2, + "Centroid Y µm": 29959.1, + "Num Detections": 7618, + "Num Negative": 5455, + "Num Positive": 2163, + "Positive %": 28.39, + "Num Positive per mm^2": 2237.0 + } +} \ No newline at end of file diff --git a/351/InvasionFront_CD3_block17_x2_y10_patient351_1.json b/351/InvasionFront_CD3_block17_x2_y10_patient351_1.json new file mode 100644 index 0000000000000000000000000000000000000000..39b20f3e0eaf8261e4f0af1efee2fa21bc6952d2 --- /dev/null +++ b/351/InvasionFront_CD3_block17_x2_y10_patient351_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5771.9, + "Centroid Y µm": 30034.1, + "Num Detections": 6481, + "Num Negative": 5526, + "Num Positive": 955, + "Positive %": 14.74, + "Num Positive per mm^2": 1057.2 + } +} \ No newline at end of file diff --git a/351/InvasionFront_CD8_block17_x1_y10_patient351_0.json b/351/InvasionFront_CD8_block17_x1_y10_patient351_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f902ac4aa6b963e1b76e5054dbf6f37b57ecda8c --- /dev/null +++ b/351/InvasionFront_CD8_block17_x1_y10_patient351_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4047.9, + "Centroid Y µm": 24711.9, + "Num Detections": 15882, + "Num Negative": 13759, + "Num Positive": 2123, + "Positive %": 13.37, + "Num Positive per mm^2": 987.89 + } +} \ No newline at end of file diff --git a/351/InvasionFront_CD8_block17_x2_y10_patient351_1.json b/351/InvasionFront_CD8_block17_x2_y10_patient351_1.json new file mode 100644 index 0000000000000000000000000000000000000000..119bb6882e6c4ae40a29e28de8a1bc98f7102148 --- /dev/null +++ b/351/InvasionFront_CD8_block17_x2_y10_patient351_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 25011.8, + "Num Detections": 15311, + "Num Negative": 14568, + "Num Positive": 743, + "Positive %": 4.853, + "Num Positive per mm^2": 322.17 + } +} \ No newline at end of file diff --git a/351/TumorCenter_CD3_block17_x1_y10_patient351_0.json b/351/TumorCenter_CD3_block17_x1_y10_patient351_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3cbde03d78ee1ba928e2c6f8332aadd5eff99950 --- /dev/null +++ b/351/TumorCenter_CD3_block17_x1_y10_patient351_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 24686.9, + "Num Detections": 13612, + "Num Negative": 12478, + "Num Positive": 1134, + "Positive %": 8.331, + "Num Positive per mm^2": 642.88 + } +} \ No newline at end of file diff --git a/351/TumorCenter_CD3_block17_x2_y10_patient351_1.json b/351/TumorCenter_CD3_block17_x2_y10_patient351_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3cc8e09d7827ef7576e38ea236655be216c5ddef --- /dev/null +++ b/351/TumorCenter_CD3_block17_x2_y10_patient351_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 24637.0, + "Num Detections": 12957, + "Num Negative": 9878, + "Num Positive": 3079, + "Positive %": 23.76, + "Num Positive per mm^2": 1660.7 + } +} \ No newline at end of file diff --git a/351/TumorCenter_CD8_block17_x1_y10_patient351_0.json b/351/TumorCenter_CD8_block17_x1_y10_patient351_0.json new file mode 100644 index 0000000000000000000000000000000000000000..02c3cce69e2e3c994c45c8535e29d0d51c96e099 --- /dev/null +++ b/351/TumorCenter_CD8_block17_x1_y10_patient351_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6552.9, + "Centroid Y µm": 38750.2, + "Num Detections": 16679, + "Num Negative": 15479, + "Num Positive": 1200, + "Positive %": 7.195, + "Num Positive per mm^2": 621.56 + } +} \ No newline at end of file diff --git a/351/TumorCenter_CD8_block17_x2_y10_patient351_1.json b/351/TumorCenter_CD8_block17_x2_y10_patient351_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1ee88d4eb29de1623ae21e299655068aa1902a8a --- /dev/null +++ b/351/TumorCenter_CD8_block17_x2_y10_patient351_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9045.2, + "Centroid Y µm": 38604.6, + "Num Detections": 13848, + "Num Negative": 11672, + "Num Positive": 2176, + "Positive %": 15.71, + "Num Positive per mm^2": 1137.2 + } +} \ No newline at end of file diff --git a/351/history_text.txt b/351/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9c29a7ee350b586da06204d07e7a7c3288767cae --- /dev/null +++ b/351/history_text.txt @@ -0,0 +1 @@ +Patient with a histologically confirmed cT3 cN2c G3 glottic and supraglottic laryngeal carcinoma on the left side, additionally a Warthin tumor sonographically on the right parotid gland with indication for the above-mentioned measures. \ No newline at end of file diff --git a/351/icd_codes.txt b/351/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc6fd121dc40d22b6fb46d31a947332bc01b0c9d --- /dev/null +++ b/351/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/351/ops_codes.txt b/351/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..75ff9c49b167e9d76170a553e786b07c6f3e9b2a --- /dev/null +++ b/351/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Biopsie an der Glottis durch Inzision[1-549.1 ] Diagnostische Ösophagogastroduodenoskopie bei normalem Situs[1-632.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Fazialismonitoring[5-262.04 R] \ No newline at end of file diff --git a/351/patient_clinical_data.json b/351/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..726c15bb1bcc2cdd9ef4e726ccdbe61f8d5b6e75 --- /dev/null +++ b/351/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 41, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/351/patient_pathological_data.json b/351/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..50968e1f68c63bc82b00c1a631797f0919624547 --- /dev/null +++ b/351/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "351", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/351/surgery_description.txt b/351/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5967dad0485e8fbee2b2f1f04e09b0bcf137d351 --- /dev/null +++ b/351/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Extracapsular dissection of right parotid, Provox Prosthesis diff --git a/351/surgery_report.txt b/351/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..00c606b35737ebbb42dd9cbdce6cc462e961c71c --- /dev/null +++ b/351/surgery_report.txt @@ -0,0 +1 @@ +Initially induction of anesthesia and transoral endotracheal intubation by the anesthesia colleagues and positioning of the patient by the surgeon. Pharyngo- and laryngoscopy are performed. The piriform sinuses on both sides, the posterior wall of the hypopharynx and the postcricoid region were unremarkable. In the area of the endolarynx, an exophytic mass was found, partially growing in the area of the left glottis and subglottically, extending approx. 10-15 mm below the glottic level. Subsequently, a flexible endoscopy of the esophagus and stomach was performed, where the findings were unremarkable. Good diaphanoscopy. Skin spray disinfection, application of local anesthetic abdominally, skin ablation and sterile draping. Problem-free insertion of a PEG tube using the thread pull-through method in the typical manner. Subsequent repositioning of the patient. Skin spray disinfection, application of local anesthesia cervically on both sides and medially, skin ablation and sterile draping. First skin incision. Cut through the subcutaneous tissue and the platysma. Formation of a subplatysmal flap up to the level above the hyoid bone. Exposure and ligation of the external jugular vein on both sides. Continuation of the right skin incision into the infraauricular region for the planned right parotid surgery. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the accessorius nerve. Exposure of the capsule of the submandibular gland, the posterior venter of the digastric muscle and the hypoglossal nerve. Exposure of the cervical vascular sheath from caudal to cranial up to the level of the posterior venter of the digaster muscle. Successive evacuation of region I b, II, III, IV and V on the right side. Several conspicuous nodules were found in region II, III on the right. Hemostasis there by means of bipolar coagulation. Subsequent exposure of the anterior border of the sternocleidomastoid muscle on the left side. Exposure of the omohyoid muscle, exposure of the posterior venter of the digaster muscle. Exposure of the capsule of the submandibular gland on the left side. Exposure of the accessorius nerve. Exposure of the cervical vascular sheath from caudal to cranial. Successive evacuation of region I b, II, III, IV and V on the left side. There are several highly visible nodes in region II, III on the left. Caudal removal of the specimen after treatment of the caudal margin by means of repositioning to avoid a chyle fistula and subsequent skeletonization of the hyoid bone. Deposition of the prelaryngeal musculature on the hyoid bone. Skeletonization of the thyroid cartilage, the cricoid cartilage and the anterior wall of the trachea after transection of the thyroid isthmus. Creation of a tracheal incision between the 3rd and 4th tracheal cartilage clasp. Re-intubation of the patient onto a size 8 laryngectomy tube, followed by skeletonization of the posterior edge of the thyroid cartilage on both sides. Preservation of the wall of the piriform sinus on both sides. Cranial exposure of the epiglottis and its free edge. Median pharyngotomy. Incision along the aryepiglottic folds on both sides. Transverse incision postcricoid. Union of all incisions. Entering the layer between the postcricoid region and the posterior wall of the cricoid cartilage. Expose the ramus between the trachea and esophagus and place the specimen at the level of the already created tracheostoma. The specimen is sent in for intraoperative frozen section examination marked with a suture (tracheal sedimentation margin), and the following 5 marginal specimens are also sent in for intraoperative frozen section examination: postcricoid, hypopharynx right, hypopharynx left, base of tongue right, base of tongue left. All marginal samples are found to be tumor-free by the pathology colleagues. Subsequently, cricopharyngeal myotomy is performed on the left paramedian in a typical manner. Insertion of a size 8 Provox prosthesis in the typical manner. Subsequent pharyngeal suture over 3 layers (mucosa, submucosa, muscular layer). The T-shaped pharyngeal suture is reinforced using Tachosil pieces cut to size. The prelaryngeal musculature is then readapted into the midline. Continuation of the right cervical skin incision into the infraauricular region. Exposure of the capsule of the parotid gland. Formation of a small flap (skin, subcutaneous tissue, SMAS) anteriorly. Subsequently entering the parotid parenchyma under electromyographic control and performing a bifocal extracapsular dissection of 2 masses in the caudal parotid capsule. Hemostasis there by means of bipolar coagulation. No facial branch is shown. Primary closure of the parotid capsule. Subsequent completion of the epithelialization of the tracheostoma. Two-layer wound closure of the entire apron flap. Placement of 2 10-gauge drains. Re-intubation of the patient to a size 10 cannula. Dressing applied. Completion of the procedure without complications. The patient received intraoperative single antibiotic Unacid 3 g intravenously. Please request suture removal on the 8th postoperative day and X-ray gruel swallow on the 10th postoperative day. \ No newline at end of file diff --git a/352/InvasionFront_CD3_block2_x5_y11_patient352_0.json b/352/InvasionFront_CD3_block2_x5_y11_patient352_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f7429bf2fa921637d3ab19042e903876a82df1b3 --- /dev/null +++ b/352/InvasionFront_CD3_block2_x5_y11_patient352_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18365.3, + "Centroid Y µm": 41153.2, + "Num Detections": 21243, + "Num Negative": 18562, + "Num Positive": 2681, + "Positive %": 12.62, + "Num Positive per mm^2": 1067.2 + } +} \ No newline at end of file diff --git a/352/InvasionFront_CD3_block2_x6_y11_patient352_1.json b/352/InvasionFront_CD3_block2_x6_y11_patient352_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1543f6fb15d9fb84e412e9eb8e78674bd562cd70 --- /dev/null +++ b/352/InvasionFront_CD3_block2_x6_y11_patient352_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20963.9, + "Centroid Y µm": 41203.2, + "Num Detections": 19783, + "Num Negative": 17406, + "Num Positive": 2377, + "Positive %": 12.02, + "Num Positive per mm^2": 1029.0 + } +} \ No newline at end of file diff --git a/352/InvasionFront_CD8_block2_x5_y11_patient352_0.json b/352/InvasionFront_CD8_block2_x5_y11_patient352_0.json new file mode 100644 index 0000000000000000000000000000000000000000..10b84224128b2b0652b12169dac34ea5a3c24665 --- /dev/null +++ b/352/InvasionFront_CD8_block2_x5_y11_patient352_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17066.0, + "Centroid Y µm": 28834.7, + "Num Detections": 24154, + "Num Negative": 23562, + "Num Positive": 592, + "Positive %": 2.451, + "Num Positive per mm^2": 242.38 + } +} \ No newline at end of file diff --git a/352/InvasionFront_CD8_block2_x6_y11_patient352_1.json b/352/InvasionFront_CD8_block2_x6_y11_patient352_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4236590197f06f415b5825a74497fb59cd050133 --- /dev/null +++ b/352/InvasionFront_CD8_block2_x6_y11_patient352_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19689.6, + "Centroid Y µm": 28909.7, + "Num Detections": 24313, + "Num Negative": 23540, + "Num Positive": 773, + "Positive %": 3.179, + "Num Positive per mm^2": 303.06 + } +} \ No newline at end of file diff --git a/352/TumorCenter_CD3_block2_x5_y11_patient352_0.json b/352/TumorCenter_CD3_block2_x5_y11_patient352_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e537c0b592ecc9dbe8420cd60ce057a24cdfba83 --- /dev/null +++ b/352/TumorCenter_CD3_block2_x5_y11_patient352_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15716.7, + "Centroid Y µm": 27260.6, + "Num Detections": 20276, + "Num Negative": 16729, + "Num Positive": 3547, + "Positive %": 17.49, + "Num Positive per mm^2": 1509.4 + } +} \ No newline at end of file diff --git a/352/TumorCenter_CD3_block2_x6_y11_patient352_1.json b/352/TumorCenter_CD3_block2_x6_y11_patient352_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7d46428db9b40885e70b0e4808fe895fa400792f --- /dev/null +++ b/352/TumorCenter_CD3_block2_x6_y11_patient352_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18265.3, + "Centroid Y µm": 27435.5, + "Num Detections": 20777, + "Num Negative": 17525, + "Num Positive": 3252, + "Positive %": 15.65, + "Num Positive per mm^2": 1353.6 + } +} \ No newline at end of file diff --git a/352/TumorCenter_CD8_block2_x5_y11_patient352_0.json b/352/TumorCenter_CD8_block2_x5_y11_patient352_0.json new file mode 100644 index 0000000000000000000000000000000000000000..018b1edb4ca7ec4083f7deedb7ed0ea3f3fa8a15 --- /dev/null +++ b/352/TumorCenter_CD8_block2_x5_y11_patient352_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18265.3, + "Centroid Y µm": 27110.6, + "Num Detections": 20626, + "Num Negative": 19536, + "Num Positive": 1090, + "Positive %": 5.285, + "Num Positive per mm^2": 467.48 + } +} \ No newline at end of file diff --git a/352/TumorCenter_CD8_block2_x6_y11_patient352_1.json b/352/TumorCenter_CD8_block2_x6_y11_patient352_1.json new file mode 100644 index 0000000000000000000000000000000000000000..757a58e4457162643db535fb3e137f15e7e7d712 --- /dev/null +++ b/352/TumorCenter_CD8_block2_x6_y11_patient352_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20789.0, + "Centroid Y µm": 27010.7, + "Num Detections": 20005, + "Num Negative": 19400, + "Num Positive": 605, + "Positive %": 3.024, + "Num Positive per mm^2": 261.07 + } +} \ No newline at end of file diff --git a/352/history_text.txt b/352/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/352/icd_codes.txt b/352/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2eb33c1be0ce09ea209a26f61fb31822405a96ab --- /dev/null +++ b/352/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Vallecula epiglottica[C10.0 ] \ No newline at end of file diff --git a/352/ops_codes.txt b/352/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6854f3c895946ed2c9d54685337f56eab27b08 --- /dev/null +++ b/352/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Partielle Resektion des Pharynx durch Pharyngotomie mit Rekonstruktion mit lokaler Schleimhaut[5-295.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Temporäre Tracheotomie[5-311.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/352/patient_clinical_data.json b/352/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9c4a31df4fae0e4615edaf1c1ce68969d454751e --- /dev/null +++ b/352/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/352/patient_pathological_data.json b/352/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7d16a379dab9b15c567fdb6027177ec1750db107 --- /dev/null +++ b/352/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "352", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/352/surgery_description.txt b/352/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f4adce0b7d55c58d8265891d2ae9d200e5be6592 --- /dev/null +++ b/352/surgery_description.txt @@ -0,0 +1 @@ +Hypopharyngeal partial resection (External pharyngotomy), Bilateral neck dissection diff --git a/352/surgery_report.txt b/352/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3debb6d4033d2648d05803150ce7bdf993601fad --- /dev/null +++ b/352/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, a PEG is first inserted. After skin disinfection, subcutaneous infiltration with local anesthetic containing adrenaline in the area of the subsequent skin incision. Sterile washing and draping. Then initially perform the tracheostomy at the usual location. After skin incision, expose and undermine the thyroid isthmus. Open the trachea between the 3rd/4th tracheal clasp and insert the tube. Then complete the mucocutaneous anastomosis caudally. Then cut around the apron flap, which is successively folded up to the chin and fixed there. Then expose the prelaryngeal and prethyroid muscles, which are placed on the hyoid bone and folded caudally. Mobilize the hyoid bone also cranially, protecting the hypoglossal nerve and the lingual artery on both sides. Exposure of the thyroid cartilage and the thyrohyoid membrane. Exposure of the two lateral horns of the hyoid bone. Then open the hypopharynx at the left lateral hyoid horn. Then look at the right epiglottis margin, which is not infiltrated by the tumor. However, the tumor reaches about half of the epiglottis so that this is also resected. The tumor is then successively removed under vision using the monopolar knife with an appropriate safety margin. The resection encompasses the entire cranial vallecula. The base of the tongue is not affected. Caudally, the incision is made through the petiolus of the epiglottis without resection of parts of the thyroid cartilage. Ultimately, the tumor can be removed in its entirety in this way. Removal of marginal incisions circularly from the resection area, all of which prove to be tumor-free in the frozen section histological diagnosis. Subsequent transition to neck dissection on the left side. Here, a large metastasis is found in the area of region II, which infiltrates the sternocleidomastoid muscle and also affects the caudal part of the parotid gland. This is first dissected from medial to lateral. In this way, the internal jugular vein can be safely protected and extracted. After securing the vascular nerve sheath, the sternocleidomastoid muscle is removed caudally and the mass is dissected cranially with resection of the accessorius nerve, which is completely surrounded by tumor masses, and removed in toto with resection of the caudal parotid pole. Neck dissection is then performed in region I with removal of the submandibular gland and regions IV and V. Transition to neck dissection on the right side. Here, too, there are several metastatic nodes, but they are mobile and not infiltrating. This means that regions I-V are completely removed on this side while preserving all non-lymphatic structures. The operation is then transferred to . The larynx is now moved cranially with several strong sutures on the lower jaw and positioned in the safe swallowing position under the base of the tongue. The prelaryngeal musculature is raised, completely covering the retaining sutures medially and refixed to the base of the tongue, thus forming the inner lining of the swallowing passage. Insertion of a Redon suction drain on both sides. Fold back the apron flap. Completion of the mucocutaneous anastomosis in the area of the tracheostoma and two-layer wound closure on both cervical sides. Sterile wound dressing. End of the operation, transfer of the patient to anesthesia. Conclusion: Resection of a vallecula carcinoma on the right side via an external pharyngotomy with resection of the entire vallecula including the epipglottis. Reconstruction of the swallowing pathway by thyropexy on the lower jaw. Simultaneous selective neck dissection of regions I-V on the right side and modified radical neck dissection on the left side with resection of the sternocleidomastoid muscle and the n. accessorius. \ No newline at end of file diff --git a/353/InvasionFront_CD3_block15_x5_y1_patient353_0.json b/353/InvasionFront_CD3_block15_x5_y1_patient353_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1425e51770a5c90770c4dd15cfefe0d0fa231e0c --- /dev/null +++ b/353/InvasionFront_CD3_block15_x5_y1_patient353_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17504.8, + "Centroid Y µm": 12211.2, + "Num Detections": 16930, + "Num Negative": 15505, + "Num Positive": 1425, + "Positive %": 8.417, + "Num Positive per mm^2": 624.8 + } +} \ No newline at end of file diff --git a/353/InvasionFront_CD3_block15_x6_y1_patient353_1.json b/353/InvasionFront_CD3_block15_x6_y1_patient353_1.json new file mode 100644 index 0000000000000000000000000000000000000000..26845e12b03ffb169e00540f8fc7d95ded9a591e --- /dev/null +++ b/353/InvasionFront_CD3_block15_x6_y1_patient353_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19926.6, + "Centroid Y µm": 11976.6, + "Num Detections": 15887, + "Num Negative": 13413, + "Num Positive": 2474, + "Positive %": 15.57, + "Num Positive per mm^2": 1098.6 + } +} \ No newline at end of file diff --git a/353/InvasionFront_CD8_block15_x5_y1_patient353_0.json b/353/InvasionFront_CD8_block15_x5_y1_patient353_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4fc6f726ddcfee5e153a24593e9bcfe0edc536b9 --- /dev/null +++ b/353/InvasionFront_CD8_block15_x5_y1_patient353_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16081.3, + "Centroid Y µm": 2325.5, + "Num Detections": 14492, + "Num Negative": 12870, + "Num Positive": 1622, + "Positive %": 11.19, + "Num Positive per mm^2": 784.52 + } +} \ No newline at end of file diff --git a/353/InvasionFront_CD8_block15_x6_y1_patient353_1.json b/353/InvasionFront_CD8_block15_x6_y1_patient353_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7939de32121c89e2779171f6a7ace3b9b8acd400 --- /dev/null +++ b/353/InvasionFront_CD8_block15_x6_y1_patient353_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18468.2, + "Centroid Y µm": 2167.7, + "Num Detections": 13621, + "Num Negative": 11639, + "Num Positive": 1982, + "Positive %": 14.55, + "Num Positive per mm^2": 927.8 + } +} \ No newline at end of file diff --git a/353/TumorCenter_CD3_block15_x5_y1_patient353_0.json b/353/TumorCenter_CD3_block15_x5_y1_patient353_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b12f2ed083553d0d0de84a1e67e83cc710bdb05 --- /dev/null +++ b/353/TumorCenter_CD3_block15_x5_y1_patient353_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 5896.9, + "Num Detections": 15709, + "Num Negative": 14839, + "Num Positive": 870, + "Positive %": 5.538, + "Num Positive per mm^2": 373.63 + } +} \ No newline at end of file diff --git a/353/TumorCenter_CD3_block15_x6_y1_patient353_1.json b/353/TumorCenter_CD3_block15_x6_y1_patient353_1.json new file mode 100644 index 0000000000000000000000000000000000000000..183d6927f70b00c48b17b1ee6c15fee983ab4aa2 --- /dev/null +++ b/353/TumorCenter_CD3_block15_x6_y1_patient353_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 5672.0, + "Num Detections": 18491, + "Num Negative": 17306, + "Num Positive": 1185, + "Positive %": 6.409, + "Num Positive per mm^2": 530.3 + } +} \ No newline at end of file diff --git a/353/TumorCenter_CD8_block15_x5_y1_patient353_0.json b/353/TumorCenter_CD8_block15_x5_y1_patient353_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3fdb98a376aa60e0604a2b7be82edaf9e6c7f6b7 --- /dev/null +++ b/353/TumorCenter_CD8_block15_x5_y1_patient353_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 2604.9, + "Num Detections": 14576, + "Num Negative": 13815, + "Num Positive": 761, + "Positive %": 5.221, + "Num Positive per mm^2": 353.56 + } +} \ No newline at end of file diff --git a/353/TumorCenter_CD8_block15_x6_y1_patient353_1.json b/353/TumorCenter_CD8_block15_x6_y1_patient353_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7f90d1694fb2b453eef9a10bb04688e2d8eaabdd --- /dev/null +++ b/353/TumorCenter_CD8_block15_x6_y1_patient353_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21388.7, + "Centroid Y µm": 2380.0, + "Num Detections": 15934, + "Num Negative": 15124, + "Num Positive": 810, + "Positive %": 5.083, + "Num Positive per mm^2": 374.6 + } +} \ No newline at end of file diff --git a/353/history_text.txt b/353/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..da46a7e1bfc26f972a89edefd14826e733c7d234 --- /dev/null +++ b/353/history_text.txt @@ -0,0 +1 @@ +The patient was diagnosed with an HPV-negative G2 squamous cell carcinoma on the right edge of the tongue. Due to the size of the tumor and the patient's wishes, the above-mentioned procedure was indicated. \ No newline at end of file diff --git a/353/icd_codes.txt b/353/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7bea55e77b75c7f00dc590613d7a4fc4fd7d6f50 --- /dev/null +++ b/353/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkrebs[C02.1 R] \ No newline at end of file diff --git a/353/ops_codes.txt b/353/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d3739697fbd69055a914287aa80afa4e9dae635 --- /dev/null +++ b/353/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Zungenamputation mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Entnahme freier Radialis-Lappen[5-858.23 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Permanente Tracheotomie[5-312.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Wechsel eines vaskulären Implantates (Zusatzkode)[5-394.3 ] \ No newline at end of file diff --git a/353/patient_clinical_data.json b/353/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f5b81bf31bb4b82c68f931481e7a65e65b56a059 --- /dev/null +++ b/353/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 68, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/353/patient_pathological_data.json b/353/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c8ef7e1cb0c3f0758e020f1deeab118e923c429a --- /dev/null +++ b/353/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "353", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 60, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 25.0 +} \ No newline at end of file diff --git a/353/surgery_description.txt b/353/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f1b3646d8f9e116a66e0ae42fe9ea76ca8bc8fe --- /dev/null +++ b/353/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy diff --git a/353/surgery_report.txt b/353/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e577338b1f17bfb17aa66ffa59961fdef93770d0 --- /dev/null +++ b/353/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia by the anesthesia colleagues and transnasal intubation. Entry with the flexible oesophagogastroscope and endoscopy into the stomach. No abnormalities here. With good diaphanoscopy, insertion of a PEG tube using the thread pull-through method. This is successful without any problems. Insertion of a covered retractor, looping of the tongue and inspection of the carcinoma. The tongue tumor occupies 2/3 of the tongue on the right side, infiltrates the entire tip of the tongue and crosses the midline. First start with tumor resection using the monopolar needle and alternate dissection with scissors and bipolar forceps. The tumor is cut around successively. In the central area, the resection appears very close macroscopically. A thick slice is immediately resected and sent for final histology. Marginal samples are then taken and sent for frozen section. All marginal samples are tumor-free. Therefore intraoperative R0 situation. Due to the large remaining defect, which has also extended to the floor of the mouth, it is essential to cover the defect. This is done with a radialis graft. Then transition to neck dissection on the right side. Skin incision on the anterior edge of the sternocleidomastoid muscle. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the cervical vascular sheath. Free preparation of the internal jugular vein. Release of the neck block II a to V a, sparing the plexus branches. The external and facial veins can be preserved. Level II contains several conspicuous, coarse nodes. Level II a to V a are removed while sparing the plexus branches and the accessorius nerve. Then neck dissection of the left side and tracheotomy (here follows dictation by ). Lifting of the radialis graft. First measure the size of the graft. This is measured at 16 x 8 cm. Then mark the graft in the area of the forearm. The forearm is small and very adipose. Cut around the skin. Then expose the cephalic vein and basilica in the area of the crook of the elbow. Exposure of the venous star with search for the confluence between the superficial and deep venous system. Exposure of the brachioradialis muscle from proximal to distal. Exposure of the superficial ramus of the radial nerve, which has two branches, both of which are preserved. Exposure of the radial artery. Clamping of the radial artery under pulsoxymetric control. Ligation of the radial artery. Lifting of the radial artery graft from the tendons and development of the pedicle in the usual manner. Deposition of the stem while preserving the interosseous outlet. A superficial vein and a deep vein can also be lifted while preserving the confluence. Separation of the nerve and suturing of the graft into the defect area. This must largely be done transcervically, as the graft cannot be fitted transorally due to the adipose conditions. For this purpose, sutures are placed in the area of the vallecula and the graft is pulled in secondarily. In the area of the soft palate and the tip of the tongue, suturing is continued transorally. In some cases, the graft must be fixed around the teeth. Ultimately, the graft fits well. Then the anastomosis is applied. Suturing of the arterial anastomosis. This succeeds without any problems. Then anastomosis of the two veins. The facial vein and a branch from the facial vein are used here. This creates good pedicle pulsation, which results in good graft perfusion. Insertion of 2 Redon drains and two-layer wound closure on both sides of the neck. The patient is ventilated and admitted to the intensive care unit. Postoperative flap control according to the usual schedule. \ No newline at end of file diff --git a/354/InvasionFront_CD3_block14_x1_y5_patient354_0.json b/354/InvasionFront_CD3_block14_x1_y5_patient354_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7c9044c4ef35d57b5b3829dd87396f8da91c14c3 --- /dev/null +++ b/354/InvasionFront_CD3_block14_x1_y5_patient354_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4672.5, + "Centroid Y µm": 16041.5, + "Num Detections": 17300, + "Num Negative": 17001, + "Num Positive": 299, + "Positive %": 1.728, + "Num Positive per mm^2": 121.76 + } +} \ No newline at end of file diff --git a/354/InvasionFront_CD3_block14_x2_y5_patient354_1.json b/354/InvasionFront_CD3_block14_x2_y5_patient354_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a48fdc4082201976f3202c5034e47d69733ca346 --- /dev/null +++ b/354/InvasionFront_CD3_block14_x2_y5_patient354_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7271.2, + "Centroid Y µm": 16141.5, + "Num Detections": 19699, + "Num Negative": 18865, + "Num Positive": 834, + "Positive %": 4.234, + "Num Positive per mm^2": 348.26 + } +} \ No newline at end of file diff --git a/354/InvasionFront_CD8_block14_x1_y5_patient354_0.json b/354/InvasionFront_CD8_block14_x1_y5_patient354_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1ce4cb1df24628823801ed78861eeff84f9400c9 --- /dev/null +++ b/354/InvasionFront_CD8_block14_x1_y5_patient354_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4859.9, + "Centroid Y µm": 12043.6, + "Num Detections": 18175, + "Num Negative": 17925, + "Num Positive": 250, + "Positive %": 1.376, + "Num Positive per mm^2": 106.85 + } +} \ No newline at end of file diff --git a/354/InvasionFront_CD8_block14_x2_y5_patient354_1.json b/354/InvasionFront_CD8_block14_x2_y5_patient354_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9b7eca42a0a562a81b43d627b2a155ec0d825421 --- /dev/null +++ b/354/InvasionFront_CD8_block14_x2_y5_patient354_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7346.1, + "Centroid Y µm": 12156.1, + "Num Detections": 15492, + "Num Negative": 15043, + "Num Positive": 449, + "Positive %": 2.898, + "Num Positive per mm^2": 234.63 + } +} \ No newline at end of file diff --git a/354/TumorCenter_CD3_block14_x1_y5_patient354_0.json b/354/TumorCenter_CD3_block14_x1_y5_patient354_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2da9dd6b04b98740aa5b13491690b62002b19570 --- /dev/null +++ b/354/TumorCenter_CD3_block14_x1_y5_patient354_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4447.6, + "Centroid Y µm": 12368.5, + "Num Detections": 15248, + "Num Negative": 14838, + "Num Positive": 410, + "Positive %": 2.689, + "Num Positive per mm^2": 175.37 + } +} \ No newline at end of file diff --git a/354/TumorCenter_CD3_block14_x2_y5_patient354_1.json b/354/TumorCenter_CD3_block14_x2_y5_patient354_1.json new file mode 100644 index 0000000000000000000000000000000000000000..80c56a7a2c50f00fa946806090754d6c58d9e80e --- /dev/null +++ b/354/TumorCenter_CD3_block14_x2_y5_patient354_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7021.3, + "Centroid Y µm": 12568.3, + "Num Detections": 11910, + "Num Negative": 11546, + "Num Positive": 364, + "Positive %": 3.056, + "Num Positive per mm^2": 176.73 + } +} \ No newline at end of file diff --git a/354/TumorCenter_CD8_block14_x1_y5_patient354_0.json b/354/TumorCenter_CD8_block14_x1_y5_patient354_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b248a6aaa7ffd042d256e73bb4cd62ba1e25495 --- /dev/null +++ b/354/TumorCenter_CD8_block14_x1_y5_patient354_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3573.1, + "Centroid Y µm": 13018.1, + "Num Detections": 17398, + "Num Negative": 17321, + "Num Positive": 77, + "Positive %": 0.4426, + "Num Positive per mm^2": 33.09 + } +} \ No newline at end of file diff --git a/354/TumorCenter_CD8_block14_x2_y5_patient354_1.json b/354/TumorCenter_CD8_block14_x2_y5_patient354_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d97918ae4d3f053f4aafdd2e019d0f4b8cdf915 --- /dev/null +++ b/354/TumorCenter_CD8_block14_x2_y5_patient354_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 13093.1, + "Num Detections": 15965, + "Num Negative": 15898, + "Num Positive": 67, + "Positive %": 0.4197, + "Num Positive per mm^2": 33.17 + } +} \ No newline at end of file diff --git a/354/history_text.txt b/354/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/354/icd_codes.txt b/354/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2abf8598d939f719940af27494207df928254b9 --- /dev/null +++ b/354/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] Bösartige Neubildung Zunge mehrere Teilbereiche überlappend[C02.8 L] \ No newline at end of file diff --git a/354/ops_codes.txt b/354/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..71f97adfda0382b8638a9be366e2a8778f562f39 --- /dev/null +++ b/354/ops_codes.txt @@ -0,0 +1 @@ +Glossektomie transoral Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-252.02 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] \ No newline at end of file diff --git a/354/patient_clinical_data.json b/354/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..90aaecb6554346dbdae5e8ee36e0c4bb8c616ece --- /dev/null +++ b/354/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 40, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/354/patient_pathological_data.json b/354/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f204c7b2b46e405ccd216cfb7c8091dee1edc4fd --- /dev/null +++ b/354/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "354", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 90, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/354/surgery_description.txt b/354/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..df1c92a77fe5d58bd095550de378a34799f6cfb6 --- /dev/null +++ b/354/surgery_description.txt @@ -0,0 +1 @@ +Glossectomy, Neck dissection, Tracheostomy, Flap diff --git a/354/surgery_report.txt b/354/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..45bba4bc02fb91e7a9a3d9f481eb53737a36d895 --- /dev/null +++ b/354/surgery_report.txt @@ -0,0 +1 @@ +After appropriate positioning, first perform transoral tumor resection with the monopolar needle. The tumor is successively removed under vision with a safety margin of about 1 cm, ultimately resulting in a hemiglossectomy. Macroscopically and palpatorily, there are no more tumor extensions. When inspecting the specimen, the safety margin in the area of the anterior floor of the mouth is 1 to 3 mm smaller than in the other direction. Therefore, a resection is taken in the area of the anterior floor of the mouth. Subsequently, marginal sections are taken from the entire circumference as well as from the base of the tumor, all of which prove to be free of tumor except for the posterior tumor base. Therefore, in the course of the operation, a large piece of the tongue is resected again in the affected area and then another peripheral incision is taken. Both samples were found to be tumor-free on frozen section histology, so that an R0 resection can now be assumed. This results in an approx. 8 x 8.5 x 5.5 large area to be reconstructed. Subsequent transition to elevation of the radial flap graft from the left forearm. Mark the S-shaped skin incision and the radialis flap to be removed while protecting the retinaculum. Sharply cut through the skin and the subcutis. Push the two muscle bellies apart and expose the very strong vascular pedicle in depth. This is dissected proximally, where a strong cubital vein star is found. In addition, 2 large-lumen veins are dissected, which will later be used for anastomosis. Expose the origin of the radial artery. Then develop the flap distally. Here, after incision on the ulnar side, the flap is developed subfascially from here to the tendon. The radial side of the flap is then also developed, sparing the sensitive radial branch. The flap is now fully developed and is left in situ until both neck dissections have been completed. Once the tumor has been resected, the neck is dissected on the right side through and simultaneously with the radial flap elevation on the left forearm. First, make an arcuate incision from the mastoid over the sternocleidomastoid muscle and curved anteriorly back towards the chin. Then dissection through the subcutaneous tissue and the platysma. The platysma is then further dissected upwards subplatysmally. The cervical anus is spared. However, this must be sacrificed later. Sparing of a vein running far anteriorly as a possible vascular connection later. Dissection of the anterior edge of the sternocleidomastoid muscle. Dissection of the omohyoid muscle. Exposure of the posterior digaster venter muscle. Then start with the lateral neck dissection. Dissection of the internal jugular vein and the accessorius nerve. At least 3 to 4 clear metastases can be seen. Removal of the upper neck specimen from level II b. Sparing of numerous accessorius branches. Dissection further caudally. Protection of the plexus branches. Then complete removal of the lateral neck preparation. Subsequent removal of the anterior neck preparation including level I a, i.e. subcutaneous tissue with lymph nodes up to the opposite left digaster venter anterior muscle. Exposure of the submandibular gland. Exposure of the vessels leading to the submandibular gland. Subsequent sharp exposure of nerve branches that run from the lingual nerve to the gland. Ligation of the Wharton's duct and complete removal of the gland. Then clearing of level II with at least one suspicious lymph node below the mandible. Subsequent preparation of possible connecting vessels for the radial artery flap, including the superior thyroid artery. Subsequently handover of the operation to . The undersigned then also performs the neck dissection on the left side. Here too, lymph node regions I to V are successively removed. There are clinical signs of metastasis in almost all regions. The jugular vein is not thrombosed, but in the middle section in the region of region III it is somewhat weak in caliber, otherwise freely pervious. Dissection of the superior thyroid artery, which will later serve as an anastomosis. There is no facial vein as such, nor is there a large-volume inflow to the internal jugular vein, so that an end-to-side anastomosis will be performed for microvascular venous anastomosis. The radial artery flap graft is then harvested from the left forearm. This is pulled through the access created in the floor of the mouth to the left side of the neck and sutured into the area of the defect. The flap is then microvascularly anastomosed, whereby the radial artery is connected to the superior thyroid artery. The venous anastomosis was performed directly to the internal jugular vein in the end-to-side anastomosis. At the final check, the anastomoses are freely patency. In addition, the stalk is loosely fixed to the surrounding muscle tissue with 2 Vicryl sutures. Insertion of a Redon suction drain and a flap. Suturing of the two neck dissection incisions on the neck. Subsequent removal of an 8 x 5 cm split-thickness skin graft from the right thigh by . The defect in the area of the left forearm is treated with this split-thickness skin. Finally, perform the tracheotomy of the visor. After sharp transection of the cutis and the subcutaneous fatty tissue, the prelaryngeal musculature in the linea alba is pushed apart. After dissection, the thyroid isthmus is clamped off on the pretracheal lamina, cut off and pushed to the side. The trachea is then opened between the 3rd and 4th tracheal clasps. Completion of the mucocutaneous anastomosis and easy insertion of an 8-gauge tracheostomy tube, onto which the patient is then intubated. Finally, the arm and thigh dressing is applied. Sterile wound dressing in the neck area. End of the operation and handover of the patient to anesthesia. Addendum: Macroscopically, there was evidence of clinical metastasis on both sides of the cervix, so that adjuvant radiochemotherapy will be indicated subsequently. \ No newline at end of file diff --git a/355/InvasionFront_CD3_block21_x3_y3_patient355_0.json b/355/InvasionFront_CD3_block21_x3_y3_patient355_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b01c4443bbcbd1e6718d0d588caec72b3bd237a4 --- /dev/null +++ b/355/InvasionFront_CD3_block21_x3_y3_patient355_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 17965.5, + "Num Detections": 12250, + "Num Negative": 12202, + "Num Positive": 48, + "Positive %": 0.3918, + "Num Positive per mm^2": 30.15 + } +} \ No newline at end of file diff --git a/355/InvasionFront_CD3_block21_x4_y3_patient355_1.json b/355/InvasionFront_CD3_block21_x4_y3_patient355_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4ead96d821d896eff357460a7025353bf3f48fd6 --- /dev/null +++ b/355/InvasionFront_CD3_block21_x4_y3_patient355_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16641.2, + "Centroid Y µm": 18090.4, + "Num Detections": 15270, + "Num Negative": 15232, + "Num Positive": 38, + "Positive %": 0.2489, + "Num Positive per mm^2": 19.11 + } +} \ No newline at end of file diff --git a/355/InvasionFront_CD8_block21_x3_y3_patient355_0.json b/355/InvasionFront_CD8_block21_x3_y3_patient355_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1728ea8296249850064cb6c98cb40d96c2017932 --- /dev/null +++ b/355/InvasionFront_CD8_block21_x3_y3_patient355_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 7496.0, + "Num Detections": 18954, + "Num Negative": 18909, + "Num Positive": 45, + "Positive %": 0.2374, + "Num Positive per mm^2": 18.77 + } +} \ No newline at end of file diff --git a/355/InvasionFront_CD8_block21_x4_y3_patient355_1.json b/355/InvasionFront_CD8_block21_x4_y3_patient355_1.json new file mode 100644 index 0000000000000000000000000000000000000000..32d1d72dc64bc6f1c937597206e7e4ecc6775124 --- /dev/null +++ b/355/InvasionFront_CD8_block21_x4_y3_patient355_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 7421.1, + "Num Detections": 19992, + "Num Negative": 19946, + "Num Positive": 46, + "Positive %": 0.2301, + "Num Positive per mm^2": 18.65 + } +} \ No newline at end of file diff --git a/355/TumorCenter_CD3_block21_x3_y3_patient355_0.json b/355/TumorCenter_CD3_block21_x3_y3_patient355_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7fe7cd3b3ee4a957d2e87fe2203ec5a2c2e02d6c --- /dev/null +++ b/355/TumorCenter_CD3_block21_x3_y3_patient355_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11049.7, + "Centroid Y µm": 9710.4, + "Num Detections": 12478, + "Num Negative": 12460, + "Num Positive": 18, + "Positive %": 0.1443, + "Num Positive per mm^2": 11.69 + } +} \ No newline at end of file diff --git a/355/TumorCenter_CD3_block21_x4_y3_patient355_1.json b/355/TumorCenter_CD3_block21_x4_y3_patient355_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0b623037f5e5fab54808b65ce0288dacf43bea3f --- /dev/null +++ b/355/TumorCenter_CD3_block21_x4_y3_patient355_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13646.3, + "Centroid Y µm": 9710.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/355/TumorCenter_CD8_block21_x3_y3_patient355_0.json b/355/TumorCenter_CD8_block21_x3_y3_patient355_0.json new file mode 100644 index 0000000000000000000000000000000000000000..80ff4adf358aeb08a3c9ee6e60828ba5036e761f --- /dev/null +++ b/355/TumorCenter_CD8_block21_x3_y3_patient355_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 22263.2, + "Num Detections": 12083, + "Num Negative": 12017, + "Num Positive": 66, + "Positive %": 0.5462, + "Num Positive per mm^2": 42.35 + } +} \ No newline at end of file diff --git a/355/TumorCenter_CD8_block21_x4_y3_patient355_1.json b/355/TumorCenter_CD8_block21_x4_y3_patient355_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1ef232f0201d9043cc16d4859af27dde4627a600 --- /dev/null +++ b/355/TumorCenter_CD8_block21_x4_y3_patient355_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 22313.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/355/history_text.txt b/355/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f26a5650f678bd8dfa86e387c4a35c14547a1cd7 --- /dev/null +++ b/355/history_text.txt @@ -0,0 +1 @@ +The patient was presented to us from an external hospital with progressive dyspnea for further diagnostics with a noticeable recurrent paresis on the right side. As far as can currently be ascertained, the patient underwent primary radiotherapy for esophageal carcinoma in 2012. After initially regular clinical monitoring, the indication for rapid panendoscopy was given in the case of an unclear change in the glottis with significant glottic stenosis. \ No newline at end of file diff --git a/355/icd_codes.txt b/355/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/355/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/355/ops_codes.txt b/355/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c340f4bb8ce4c9dbb386b29f9bbeab2444aaf9f6 --- /dev/null +++ b/355/ops_codes.txt @@ -0,0 +1 @@ +Exzision erkranktes Gewebe Larynx mikrolaryngoskopisch[5-300.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/355/patient_clinical_data.json b/355/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6d92f2a46c973f4f18cb58cf2d58fe6d02608182 --- /dev/null +++ b/355/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/355/patient_pathological_data.json b/355/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..00bf111e4aa4f363c350d6d52effd183e8b6c048 --- /dev/null +++ b/355/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "355", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/355/surgery_description.txt b/355/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8e7c2046b26517f91cf154011afd895a47501d55 --- /dev/null +++ b/355/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Microlaryngoscopic tumor debulking (Laser) diff --git a/355/surgery_report.txt b/355/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..652085b1281892ea0ebbed56a0c205800236fe41 --- /dev/null +++ b/355/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by anesthesia colleagues, together with anesthesia, laryngoscopy and attempt at tracheoscopy. The glottic plane itself is largely displaced with a well adjustable glottic plane, a complete passage with the tracheoscope is initially unsuccessful, but intubation is nevertheless problem-free. After positioning the patient, first turn to flexible esophagogastroscopy. To do this, enter with the gastroscope under laryngoscopic control. Careful pre-scanning under constant air insufflation into the stomach - this is successful without any problems despite pre-therapy. The stomach itself is inconspicuous and clear. On reflection, the esophagus shows postradiogenic changes, in part somewhat vulnerable and especially in the distal part with typical postradiogenic telangiectasia, but without suspicious parts. As far as can be assessed, no evidence of recurrence of the previously known esophageal carcinoma. Now entering with the Kleinsasser tube under dental protection after inspection of the inconspicuous oral vestibule. The oral cavity, including the floor of the mouth, tongue and soft palate, is unremarkable. Also the oropharynx, with a slightly hyperplastic tongue base and folded vallecula, otherwise tumor-free. Inspection of the hypopharynx, which is unremarkable and clear up to the tips of the piriform sinus and the entrance to the esophagus, and the postcricoid region is also clear. On exposure of the glottic plane, an exophytic, largely ulcerated tumor can now be seen, which infiltrates the entire hemilarynx, extends extensively into the anterior commissure and largely displaces the glottic plane. As far as possible due to the tumor masses, adjustment of the subglottic level. Here, too, a subglottic growth of at least 1.5 cm can be seen, especially in the area of the anterior commissure, below which the mucosa appears to be free again, as far as can be assessed. The right pocket fold is edematous and submucosally indurated. Tumor growth is also present here. The right vocal cord level is also largely consumed by tumor. At the transition to both arytenoids, regular mucosa can be seen again, so that the tumor growth remains limited to the endolaryngeal area of the mucosa, however, transition to the subglottis. After demonstrating the findings and discussing the case with , the decision was made to debulk the tumor due to the extent of the tumor and the clinical condition in order to avoid a premature tracheostomy. Adjustment of the glottic plane with the small bore tube. Securing of the tube with compresses and subsequent tumor debulking with the CO2 laser with retraction of both vocal folds consumed by the tumor. Laser vaporization of the open tumour and laser vaporization of the adjacent mucosal oedema and creation of a wide glottic gap. Confirmation of subglottic expansion. Subsequently, with dry endolaryngeal conditions and wide glottic access, termination of the procedure at this point. Subsequent extubation of the patient without any problems. The samples were sent for urgent definitive histology. Conclusion: Overall, high-grade diagnosis of at least cT3 glottic carcinoma with extension to the subglottis. Postoperatively, please demonstrate the findings of the CT imaging to our colleagues in radiology - as far as can be assessed, there appears to be arrosion of the thyroid cartilage, but no breakthrough. Depending on the assessment by our radiology colleagues, repeat imaging if necessary. After receiving the definitive histology, please present the multimorbid patient to our interdisciplinary tumor conference. The tumor appears to be easily resectable via a laryngectomy - please complete the preliminary findings with evaluation of the radiation field. If the larynx was in the radiation field during the initial treatment, flap coverage is also indicated. Interdisciplinary case discussion, if necessary also with colleagues from internal medicine and anesthesia, alternatively primarily palliative supportive procedure. \ No newline at end of file diff --git a/356/InvasionFront_CD3_block1_x3_y8_patient356_0.json b/356/InvasionFront_CD3_block1_x3_y8_patient356_0.json new file mode 100644 index 0000000000000000000000000000000000000000..939cc8406749a5e6491185d61f65f25add0f2b94 --- /dev/null +++ b/356/InvasionFront_CD3_block1_x3_y8_patient356_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11203.3, + "Centroid Y µm": 21748.6, + "Num Detections": 9974, + "Num Negative": 9584, + "Num Positive": 390, + "Positive %": 3.91, + "Num Positive per mm^2": 348.9 + } +} \ No newline at end of file diff --git a/356/InvasionFront_CD3_block1_x4_y8_patient356_1.json b/356/InvasionFront_CD3_block1_x4_y8_patient356_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c69a9346c64f2432792f0f313bb143b87f101cdc --- /dev/null +++ b/356/InvasionFront_CD3_block1_x4_y8_patient356_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 21863.4, + "Num Detections": 7810, + "Num Negative": 7792, + "Num Positive": 18, + "Positive %": 0.2305, + "Num Positive per mm^2": 16.8 + } +} \ No newline at end of file diff --git a/356/InvasionFront_CD8_block1_x3_y8_patient356_0.json b/356/InvasionFront_CD8_block1_x3_y8_patient356_0.json new file mode 100644 index 0000000000000000000000000000000000000000..99268dee72356f737ba82a2387a0d29d887cfe43 --- /dev/null +++ b/356/InvasionFront_CD8_block1_x3_y8_patient356_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11277.5, + "Centroid Y µm": 20294.7, + "Num Detections": 8860, + "Num Negative": 8743, + "Num Positive": 117, + "Positive %": 1.321, + "Num Positive per mm^2": 115.36 + } +} \ No newline at end of file diff --git a/356/InvasionFront_CD8_block1_x4_y8_patient356_1.json b/356/InvasionFront_CD8_block1_x4_y8_patient356_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9b932fc7e6da9cc1dd99bd99155668487de29e22 --- /dev/null +++ b/356/InvasionFront_CD8_block1_x4_y8_patient356_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13855.3, + "Centroid Y µm": 20415.7, + "Num Detections": 6691, + "Num Negative": 6669, + "Num Positive": 22, + "Positive %": 0.3288, + "Num Positive per mm^2": 26.21 + } +} \ No newline at end of file diff --git a/356/TumorCenter_CD3_block1_x3_y10_patient356_0.json b/356/TumorCenter_CD3_block1_x3_y10_patient356_0.json new file mode 100644 index 0000000000000000000000000000000000000000..191ddc6c9aab461db2f4edb946e62b353385b4ef --- /dev/null +++ b/356/TumorCenter_CD3_block1_x3_y10_patient356_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 24811.9, + "Num Detections": 23963, + "Num Negative": 20052, + "Num Positive": 3911, + "Positive %": 16.32, + "Num Positive per mm^2": 1427.7 + } +} \ No newline at end of file diff --git a/356/TumorCenter_CD3_block1_x4_y10_patient356_1.json b/356/TumorCenter_CD3_block1_x4_y10_patient356_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1c74901f6f683c7214b52098c3fc6853f59d45a9 --- /dev/null +++ b/356/TumorCenter_CD3_block1_x4_y10_patient356_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 24911.8, + "Num Detections": 16136, + "Num Negative": 15354, + "Num Positive": 782, + "Positive %": 4.846, + "Num Positive per mm^2": 414.7 + } +} \ No newline at end of file diff --git a/356/TumorCenter_CD8_block1_x3_y8_patient356_0.json b/356/TumorCenter_CD8_block1_x3_y8_patient356_0.json new file mode 100644 index 0000000000000000000000000000000000000000..523465b1e80b6ca2f0903fb12089d4c3706365f3 --- /dev/null +++ b/356/TumorCenter_CD8_block1_x3_y8_patient356_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 28784.8, + "Num Detections": 11188, + "Num Negative": 11183, + "Num Positive": 5, + "Positive %": 0.0447, + "Num Positive per mm^2": 3.414 + } +} \ No newline at end of file diff --git a/356/TumorCenter_CD8_block1_x4_y8_patient356_1.json b/356/TumorCenter_CD8_block1_x4_y8_patient356_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c304ada873c08e94650f774ee7d8209286ba886 --- /dev/null +++ b/356/TumorCenter_CD8_block1_x4_y8_patient356_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 28784.8, + "Num Detections": 7952, + "Num Negative": 7942, + "Num Positive": 10, + "Positive %": 0.1258, + "Num Positive per mm^2": 10.82 + } +} \ No newline at end of file diff --git a/356/history_text.txt b/356/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/356/icd_codes.txt b/356/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/356/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/356/ops_codes.txt b/356/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f002ddfc9e5a2b4162190ecd58c5679460966b39 --- /dev/null +++ b/356/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Anlage eines Systems zur Vakuumversiegelung an Haut und Unterhaut[5-916.a0 ] Kontinuierliche Sogbehandlung bei Vakuumversiegelung Bis 7 Tage[8-190.10 ] Entnahme Vollhaut zur Transplantation sonstige[5-901.1x R] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Resektion Tracheagewebe mit Anlegen eines Tracheostoma[5-314.12 ] \ No newline at end of file diff --git a/356/patient_clinical_data.json b/356/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f656cbe2aa3b16103b89c8f7f474ba1a9a757756 --- /dev/null +++ b/356/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/356/patient_pathological_data.json b/356/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2ddf432440dd6d082e9e55de12f235ab8c803023 --- /dev/null +++ b/356/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "356", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 28, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/356/surgery_description.txt b/356/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f10d94f184da1664e28cf78599908707fdcf6f40 --- /dev/null +++ b/356/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheostomy, Defect coverage, Free flap (Radial) diff --git a/356/surgery_report.txt b/356/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f78555e331de343512c8ea530078e7c7694f57d0 --- /dev/null +++ b/356/surgery_report.txt @@ -0,0 +1 @@ +First insertion of the oral retractor and the frontal sinus retractor and resection of the tumor in the area of the left oropharynx. The tumor extends from the tonsil lobe in a cone shape along the lateral pharyngeal wall caudally, passes over to the caudal base of the tongue and takes up about 1/4 of the tongue base growing superficially until it finally passes over to the dorsal floor of the mouth, glossotonsillar groove, mandibular angulus and the soft palate. Here the tumor extends to the parauvular region, where the resection is completed accordingly. The entire specimen is sent for frozen section assessment after marking the wound edges accordingly. Meanwhile, start the left neck dissection: To do this, make a skin incision along a cervical skin fold in the direction of the mastoid. Dissection of cranial and caudal platysmal flaps and exposure of the internal jugular vein and the auricular nerve. While the nerve can be spared, the vein ultimately lies across the situs so that it must be ligated as cranially as possible. Further dissection along the anterior edge of the sternocleidomastoid muscle and exposure of the vascular nerve sheath. Dissection along the omohyoid muscle to the hyoid bone and along the digastric muscle to complete neck dissection level II to IV. Careful elevation of the neck block. A macroscopic metastasis is found in the area of level IIb. Here the accessory nerve passes through one of the two macroscopically conspicuous lymph nodes so that it must be resected. Otherwise, spare all vascular and nerve structures. Subsequently, careful evacuation of level V up to above the cervical plexus. Finally, lateral pharyngotomy after evacuation of level I, taking the submandibular gland with it. This was already visible enorally in the sense of the wound bed. As the frozen section diagnostics that had been performed in the meantime had described an R1 situation in the basal part, among others, this part was completely removed in the sense of a thorough resection. The facial and lingual arteries were ligated. The hypoglossal nerve, however, can be spared. Wide opening of the pharynx to the enoral defect. Neck dissection now follows on the right side by and parallel to this the elevation of the forearm graft by and . Transition to neck dissection on the right side. Mark the course of the mandible and the ascending mandibular branch as well as the mastoid. Create a curved skin incision extending laterally in the area of the anterior edge of the sternocleidomastoid muscle. Sharp dissection of the subcutaneous fatty tissue and the platysma. Subsequent subplatysmal dissection. Subsequent exposure of the anterior edge of the sternocleidomastoid muscle and exposure of the omohyoid muscle as the caudal border. Subsequent dissection of the omohyoid muscle up to the hyoid. Subsequent dissection and visualization of the posterior surface of the sternocleidomastoid and the course of the accessorius nerve. Then move on to exposing the submandibular gland and the digastric muscle as the cranial border. Also exposure and intraoperative protection of the hypoglossal nerve. Beginning of exposure of the cervical vascular sheath. Exposure of the internal jugular vein and the facial vein in its entire course up to the cranial border. The external jugular vein was cut off intraoperatively for reasons of clarity. The course of the common carotid artery was then exposed. After exposure of all the above-mentioned landmarks, the medial and lateral neck specimens are removed after successive dissection. On the right side, apart from the external jugular vein, all large branches of the external jugular vein and external carotid artery were preserved. Hemostasis using bipolar coagulation and wound irrigation with Ringer's solution. Subsequent placement of a 10-gauge Redondra ring and two-layer wound closure. This results in a functional neck dissection on the right side in regions II, III and IV. The findings are then demonstrated . Meanwhile, elevation of the forearm graft. For this purpose, draw the graft with a size of approx. 10 x 5 cm, taking into account the exact anatomy, so that the width is drawn variably. A skin monitor is integrated into the drawing for postoperative monitoring of the graft. Careful elevation of the graft, taking the cephalic vein with it. Separation of the radial vascular pedicle after appropriate preparation and elevation from distal to proximal into the crook of the elbow. Here the confluence of the superficial and deep venous system is sought out and identified as well as the outlet of the radial artery from the ulnar artery. Appropriate ligatures and removal of the vascular pedicle. Beforehand, the tourniquet (300 mmHg) is opened and careful hemostasis is performed. The lifted graft is now retracted from cervical to enoral and carefully incorporated using appropriate single-button Vicryl sutures (3.0). This results in complete coverage of the defect and satisfactory reconstruction of the oropharyngeal region. Parallel to the incorporation, full-thickness skin is lifted from the right groin and the lifting defect on the right forearm is treated with full-thickness skin and continuous suturing. Application of a vacuum dressing, which should be left in place for 7 days. Splinting of the arm with special attention to finger fixation. Meanwhile cervical vascular sutures. The superior thyroid artery is connected to the radial artery in the sense of an end-to-end anastomosis. The excellent flow of the superior thyroid artery is checked beforehand. After appropriate demonstration of good venous return, the flap vein is now connected to a branch of the facial vein using a size 2.5 coupler in the sense of an end-to-end anastomosis. To stabilize the curved course of the venous vessel and to prevent kinking, a small gelatin sponge is inserted into the curvature. The vascular monitor is now positioned correctly to stabilize the flap pedicle and incorporated into the neck skin. Subcutaneous sutures and skin suture. On the right side, insertion of a 10 mm Redon drain and also subcutaneous and skin sutures. Subsequent tracheostoma placement by to temporarily secure the airway postoperatively. The stoma can be closed again once sufficient swallowing has been ensured and the swelling has subsided enorally with adequate breathing. The wound in the groin area is primarily treated with subcutaneous sutures and skin sutures. Insertion of an 8-gauge Duracuff cannula with core. This is sutured in place. The sutures should be removed after 5 days. Only then can the cannula be fixed in place with the appropriate tape. Classic monitoring of the transplant for 5 days, according to the applicable regulations and no bandages or tapes in the neck area for at least 5 days. The upper body should be elevated at approx. 45°. \ No newline at end of file diff --git a/357/InvasionFront_CD3_block1_x3_y2_patient357_0.json b/357/InvasionFront_CD3_block1_x3_y2_patient357_0.json new file mode 100644 index 0000000000000000000000000000000000000000..57c3e6b0cf8aa2d8509996b6070386f17e2eddaa --- /dev/null +++ b/357/InvasionFront_CD3_block1_x3_y2_patient357_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11743.8, + "Centroid Y µm": 6671.5, + "Num Detections": 24018, + "Num Negative": 23551, + "Num Positive": 467, + "Positive %": 1.944, + "Num Positive per mm^2": 188.6 + } +} \ No newline at end of file diff --git a/357/InvasionFront_CD3_block1_x4_y2_patient357_1.json b/357/InvasionFront_CD3_block1_x4_y2_patient357_1.json new file mode 100644 index 0000000000000000000000000000000000000000..618fb5eeb909ff0f9f2edfe5eec83ed6b2b3e76b --- /dev/null +++ b/357/InvasionFront_CD3_block1_x4_y2_patient357_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14392.4, + "Centroid Y µm": 6821.4, + "Num Detections": 21052, + "Num Negative": 20836, + "Num Positive": 216, + "Positive %": 1.026, + "Num Positive per mm^2": 92.51 + } +} \ No newline at end of file diff --git a/357/InvasionFront_CD8_block1_x3_y2_patient357_0.json b/357/InvasionFront_CD8_block1_x3_y2_patient357_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5c91ae52812073ae73ccc9d456438e34b72711d7 --- /dev/null +++ b/357/InvasionFront_CD8_block1_x3_y2_patient357_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11968.7, + "Centroid Y µm": 5247.2, + "Num Detections": 23320, + "Num Negative": 22363, + "Num Positive": 957, + "Positive %": 4.104, + "Num Positive per mm^2": 381.19 + } +} \ No newline at end of file diff --git a/357/InvasionFront_CD8_block1_x4_y2_patient357_1.json b/357/InvasionFront_CD8_block1_x4_y2_patient357_1.json new file mode 100644 index 0000000000000000000000000000000000000000..757ea52a5414bb862b32ba6fc1faa56fa2b53237 --- /dev/null +++ b/357/InvasionFront_CD8_block1_x4_y2_patient357_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14592.3, + "Centroid Y µm": 5497.1, + "Num Detections": 18000, + "Num Negative": 17765, + "Num Positive": 235, + "Positive %": 1.306, + "Num Positive per mm^2": 115.48 + } +} \ No newline at end of file diff --git a/357/TumorCenter_CD3_block1_x3_y4_patient357_0.json b/357/TumorCenter_CD3_block1_x3_y4_patient357_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e167b1c9309cbae4427e8ed459848d8809bacac3 --- /dev/null +++ b/357/TumorCenter_CD3_block1_x3_y4_patient357_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10519.4, + "Centroid Y µm": 10194.6, + "Num Detections": 27209, + "Num Negative": 25609, + "Num Positive": 1600, + "Positive %": 5.88, + "Num Positive per mm^2": 572.13 + } +} \ No newline at end of file diff --git a/357/TumorCenter_CD3_block1_x4_y4_patient357_1.json b/357/TumorCenter_CD3_block1_x4_y4_patient357_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f3b8536e0bfea9a4b14c593bfd3099b6cdb18379 --- /dev/null +++ b/357/TumorCenter_CD3_block1_x4_y4_patient357_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13018.1, + "Centroid Y µm": 10094.7, + "Num Detections": 22203, + "Num Negative": 19825, + "Num Positive": 2378, + "Positive %": 10.71, + "Num Positive per mm^2": 921.71 + } +} \ No newline at end of file diff --git a/357/TumorCenter_CD8_block1_x3_y2_patient357_0.json b/357/TumorCenter_CD8_block1_x3_y2_patient357_0.json new file mode 100644 index 0000000000000000000000000000000000000000..da2c8ea05a9ef384a5c5c7a9bd28c82fa23f71a1 --- /dev/null +++ b/357/TumorCenter_CD8_block1_x3_y2_patient357_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 13792.7, + "Num Detections": 23822, + "Num Negative": 23371, + "Num Positive": 451, + "Positive %": 1.893, + "Num Positive per mm^2": 188.7 + } +} \ No newline at end of file diff --git a/357/TumorCenter_CD8_block1_x4_y2_patient357_1.json b/357/TumorCenter_CD8_block1_x4_y2_patient357_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ff721ee6cb97de0a7d806be1089868b76e44050f --- /dev/null +++ b/357/TumorCenter_CD8_block1_x4_y2_patient357_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 13792.7, + "Num Detections": 23766, + "Num Negative": 22646, + "Num Positive": 1120, + "Positive %": 4.713, + "Num Positive per mm^2": 487.03 + } +} \ No newline at end of file diff --git a/357/history_text.txt b/357/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/357/icd_codes.txt b/357/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/357/ops_codes.txt b/357/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/357/patient_clinical_data.json b/357/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c3b7cb34e43a36bd27c435c7144890dd7c7bf24b --- /dev/null +++ b/357/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/357/patient_pathological_data.json b/357/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0558f5d465313eb4820b4b105613861e7ad20af6 --- /dev/null +++ b/357/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "357", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/357/surgery_description.txt b/357/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9ef55f66910e6707f9216b0794c2a0146110434c --- /dev/null +++ b/357/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Feeding tube diff --git a/357/surgery_report.txt b/357/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/358/InvasionFront_CD3_block9_x1_y9_patient358_0.json b/358/InvasionFront_CD3_block9_x1_y9_patient358_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3a4764b67e396964913162da3c6789f583e2cba9 --- /dev/null +++ b/358/InvasionFront_CD3_block9_x1_y9_patient358_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4372.7, + "Centroid Y µm": 22313.2, + "Num Detections": 17752, + "Num Negative": 15166, + "Num Positive": 2586, + "Positive %": 14.57, + "Num Positive per mm^2": 1189.0 + } +} \ No newline at end of file diff --git a/358/InvasionFront_CD3_block9_x2_y9_patient358_1.json b/358/InvasionFront_CD3_block9_x2_y9_patient358_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cddfee10448d99b9edd04718310e5c9ca6e8c65e --- /dev/null +++ b/358/InvasionFront_CD3_block9_x2_y9_patient358_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7146.2, + "Centroid Y µm": 22513.1, + "Num Detections": 21728, + "Num Negative": 18376, + "Num Positive": 3352, + "Positive %": 15.43, + "Num Positive per mm^2": 1401.4 + } +} \ No newline at end of file diff --git a/358/InvasionFront_CD8_block9_x1_y9_patient358_0.json b/358/InvasionFront_CD8_block9_x1_y9_patient358_0.json new file mode 100644 index 0000000000000000000000000000000000000000..444959003c45f3540f852da08d6b767b32a1e5da --- /dev/null +++ b/358/InvasionFront_CD8_block9_x1_y9_patient358_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4522.6, + "Centroid Y µm": 25986.2, + "Num Detections": 17261, + "Num Negative": 12049, + "Num Positive": 5212, + "Positive %": 30.2, + "Num Positive per mm^2": 2396.9 + } +} \ No newline at end of file diff --git a/358/InvasionFront_CD8_block9_x2_y9_patient358_1.json b/358/InvasionFront_CD8_block9_x2_y9_patient358_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9c729d915789ce1860306988c48dc86bd7ad5a23 --- /dev/null +++ b/358/InvasionFront_CD8_block9_x2_y9_patient358_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7371.1, + "Centroid Y µm": 26086.2, + "Num Detections": 20844, + "Num Negative": 11660, + "Num Positive": 9184, + "Positive %": 44.06, + "Num Positive per mm^2": 3980.1 + } +} \ No newline at end of file diff --git a/358/TumorCenter_CD3_block9_x1_y9_patient358_0.json b/358/TumorCenter_CD3_block9_x1_y9_patient358_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cc893f787a6c53c1a54b9684dd8978fd7eea43e5 --- /dev/null +++ b/358/TumorCenter_CD3_block9_x1_y9_patient358_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 27935.2, + "Num Detections": 20491, + "Num Negative": 10480, + "Num Positive": 10011, + "Positive %": 48.86, + "Num Positive per mm^2": 4127.0 + } +} \ No newline at end of file diff --git a/358/TumorCenter_CD3_block9_x2_y9_patient358_1.json b/358/TumorCenter_CD3_block9_x2_y9_patient358_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f9a4fc1495cf1dc7a8773ff4e8bd01a56120e1b6 --- /dev/null +++ b/358/TumorCenter_CD3_block9_x2_y9_patient358_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 28010.2, + "Num Detections": 20395, + "Num Negative": 7116, + "Num Positive": 13279, + "Positive %": 65.11, + "Num Positive per mm^2": 5473.7 + } +} \ No newline at end of file diff --git a/358/TumorCenter_CD8_block9_x1_y9_patient358_0.json b/358/TumorCenter_CD8_block9_x1_y9_patient358_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f87137ba825ede3b7947935f2d3eb9a179eaa80d --- /dev/null +++ b/358/TumorCenter_CD8_block9_x1_y9_patient358_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 24012.3, + "Num Detections": 19816, + "Num Negative": 11076, + "Num Positive": 8740, + "Positive %": 44.11, + "Num Positive per mm^2": 3489.6 + } +} \ No newline at end of file diff --git a/358/TumorCenter_CD8_block9_x2_y9_patient358_1.json b/358/TumorCenter_CD8_block9_x2_y9_patient358_1.json new file mode 100644 index 0000000000000000000000000000000000000000..652e5a996bdf6b80aace6224228cafb1c0b827af --- /dev/null +++ b/358/TumorCenter_CD8_block9_x2_y9_patient358_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 23887.4, + "Num Detections": 19613, + "Num Negative": 8579, + "Num Positive": 11034, + "Positive %": 56.26, + "Num Positive per mm^2": 4446.3 + } +} \ No newline at end of file diff --git a/358/history_text.txt b/358/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f70c852cadd18e16db103331b04f498a0f1625a8 --- /dev/null +++ b/358/history_text.txt @@ -0,0 +1 @@ +In the patient <2014>, a cT1 to 2 cN2a oropharyngeal carcinoma in the area of the tonsil on the right was histologically confirmed during a panendoscopy. Recommendation of primary surgical treatment in our interdisciplinary tumor conference. Immediate preoperative confirmation of the sonographic cN2a neck status with clinically prominent mass in level II on the right. \ No newline at end of file diff --git a/358/icd_codes.txt b/358/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adab28f0b88ba31c5bb4895a3d4f3034f2967b3e --- /dev/null +++ b/358/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] \ No newline at end of file diff --git a/358/ops_codes.txt b/358/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..20202f518d2370416797d9093f09fe8cac2ec9ad --- /dev/null +++ b/358/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Permanente Tracheotomie[5-312.0 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] PEG-Sonde Anlage[5-431.2 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Kontinuierliche Sogbehandlung mit sonstigen Systemen bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.30 ] \ No newline at end of file diff --git a/358/patient_clinical_data.json b/358/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0a02ab1ee821d0b9ed76a40da0cf5146d7c41da5 --- /dev/null +++ b/358/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 57, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/358/patient_pathological_data.json b/358/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..453e9bd45eb78c8a91be4aca4e4d9920b58807cd --- /dev/null +++ b/358/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "358", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 58, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/358/surgery_description.txt b/358/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a76ab3bbe429d60b63455c75d701defd404772cf --- /dev/null +++ b/358/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Flap coverage (Radial), Tracheotomy, PEG placement diff --git a/358/surgery_report.txt b/358/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a221bf5eac751b0f727a1693240f1794c01c4a5a --- /dev/null +++ b/358/surgery_report.txt @@ -0,0 +1 @@ +First inspection of the primary tumor region after intubation by the anesthesia colleagues. Positioning of the patient. Entry with the tonsillar retractor. Inspection and palpation. The exophytic lesion can be seen in the area of the right tonsil lobe. On palpation, the lesion is submucosal and extending into the soft palate, with infiltration of the posterior palatal arch. Laterally, the mass is still displaceable. In this case, the tonsil capsule is barely exceeded. The tumor is now resected in the sense of a radical tonsillectomy. In the area of the submucosal part of the soft palate, the resection must be carried out as far as the parauvular area and a clear resection of the soft palate. The tumor itself is relatively well encapsulated, but takes up the entire tonsil lobe. Inclusion of the posterior palatal arch muscularly and in the area of the mucosal level. A muscle cuff is also left laterally and the lower tonsil pole is included. In this case, the tumor does not significantly protrude. On the specimen, the specimen is now resected in sano, but with encapsulation basally probably histologically barely in sano resection. Therefore, the tumor is completely covered basally and in the mucosal area by taking marginal samples. These are diagnosed as completely free of tumor and dysplasia in the frozen section diagnostics, so that a reliable R0 situation is present here. Due to the resection down to the soft tissues of the neck and the large area of exposed neck fatty tissue as well as the resection of almost half of the soft palate and resection of the posterior palatal arch, a radialis graft is indicated to cover the defect for the best possible functionality. The PEG tube is initially inserted if the neck status is positive. Insertion with the gastroscope under laryngoscopic control. Easy pre-transmission into the stomach. If the mucosal conditions here are unremarkable and the diaphanoscopy is good, the stomach is punctured without any problems and the PEG tube is then inserted using the usual thread pull-through method. Neck dissection of the left side is then performed first. Submandibular incision. Separation of skin and subcutaneous tissue. Dissection of the platysma for complete exposure of the neck area. Perform a functional neck dissection level II to IV, exposing and protecting the submandibular gland, sternocleidomastoid muscle, omohyoid muscle, digastric muscle, internal jugular vein, facial vein, cervical artery, superior thyroid artery, hypoglossal nerve and accessory nerve. Followed by careful wound inspection, wound irrigation and, if the wound is dry, insertion of a 10-gauge Redon drain and careful, two-layer wound closure. Turning to the opposite side. Here in level II, a mass measuring approx. 4 cm. First cut through the skin and subcutaneous tissue. Dissection of the platysma, which is not infiltrated. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digastric muscle. The mass is relatively smoothly encapsulated, no infiltration of the sternocleidomastoid muscle. Free preparation of the anterior neck specimen, with careful protection of the hypoglossal nerve, superior thyroid artery and facial vein. Dissection of the internal jugular vein. The mass lies on the vein, compresses it, but does not infiltrate it. Similarly, exposure and preservation of the accessorius nerve, which is also only in contact with the mass. There is also no infiltration of the digastric muscle. Complete the neck in level V, carefully preserving the cervical plexus branches. Finally, resection of the digastric muscle and performance of a pharyngotomy and creation of a tunnel measuring approx. 3 transverse fingers enorally for compression-free style positioning. The radialis graft is now removed from the left forearm in a bloodless state. Draw a graft measuring 10 x 5 cm in total with a special soft palate configuration. Trimming of the graft. Radial dissection with the cephalic vein located far dorsally, leaving it intact. Exposure and preservation of the ramus superficialis nervi radialis. Exposure of the brachioradialis muscle. Distal transection of the radial artery. Ulnar preparation. Strictly subfascial preparation and release of the specimen. Isolation on the vascular pedicle. Exposure and preservation of the common interosseous artery. Exposure and dissection of a venous confluence and removal of the excellent vital graft, after reopening of the tourniquet and regular hand perfusion. Subsequent careful wound inspection and hemostasis in the forearm area. Careful wound closure and incorporation of the full-thickness skin graft harvested from the right groin. Subsequent application of the vacuum pump. Application of the Kramer splint in the functional position and repositioning of the arm at the end of the procedure. For full-thickness skin harvesting from the right groin. Incision of a spindle-shaped area of skin measuring 12 x 5 cm in total. Strictly cutaneous lifting. Followed by subcutaneous mobilization. Hemostasis and, if the wound is dry, insertion of a 10-gauge Redon drain and careful, multi-layer wound closure under moderate tension. The radialis graft is then incorporated. Despite the advanced swelling of the tongue, this was sufficient and regular. Good soft palate reconstruction and intact conditions on all sides. Stalk positioning and conditioning of the superior thyroid artery and performance of the arterial anastomosis with 8-0 Ethilon. Subsequently, immediate regular venous return and good graft perfusion. Conditioning of the facial vein and insertion of the venous anastomosis with the size 3.5 coupler, followed by careful irrigation of the wound if the graft circulation is normal and, if the wound is dry, insertion of a 10 Redon drain and careful, two-layer wound closure. Subsequently, due to the advanced swelling of the tongue and the extent of the graft, a protective tracheostomy is performed. This involves a circumscribed skin incision below the cricoid cartilage. Cut through skin and subcutaneous tissue. Exposure and transection of the infrahyoid musculature. Dissection of the thyroid isthmus. In the case of protective tracheotomy, only punctual epithelialization. Subsequent problem-free reintubation to a size 8 low-cuff cannula, suture-fixed. The procedure was then completed without complications. Conclusion: Intraoperatively R0 resected cT2 cN2a tonsillar carcinoma on the right. Postoperative meticulous flap monitoring by enoral inspection. If the graft has healed properly, the patient can be gradually built up and decannulated from the 7th to 8th postoperative day. After receiving the definitive histology, presentation at our interdisciplinary tumor conference to determine the adjuvant therapy. \ No newline at end of file diff --git a/359/InvasionFront_CD3_block2_x5_y4_patient359_0.json b/359/InvasionFront_CD3_block2_x5_y4_patient359_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3159ad749af510fe1f1792f272f8c9e394d82d80 --- /dev/null +++ b/359/InvasionFront_CD3_block2_x5_y4_patient359_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 23612.5, + "Num Detections": 16743, + "Num Negative": 16586, + "Num Positive": 157, + "Positive %": 0.9377, + "Num Positive per mm^2": 78.42 + } +} \ No newline at end of file diff --git a/359/InvasionFront_CD3_block2_x6_y4_patient359_1.json b/359/InvasionFront_CD3_block2_x6_y4_patient359_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0afe00910e90277a278c1fcec7d57cc095ac3728 --- /dev/null +++ b/359/InvasionFront_CD3_block2_x6_y4_patient359_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21438.6, + "Centroid Y µm": 23537.5, + "Num Detections": 24553, + "Num Negative": 19661, + "Num Positive": 4892, + "Positive %": 19.92, + "Num Positive per mm^2": 1915.6 + } +} \ No newline at end of file diff --git a/359/InvasionFront_CD8_block2_x5_y4_patient359_0.json b/359/InvasionFront_CD8_block2_x5_y4_patient359_0.json new file mode 100644 index 0000000000000000000000000000000000000000..56a8d23f0c53fb0d4a33edabf98f62d413db5675 --- /dev/null +++ b/359/InvasionFront_CD8_block2_x5_y4_patient359_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17740.6, + "Centroid Y µm": 11394.0, + "Num Detections": 12772, + "Num Negative": 12657, + "Num Positive": 115, + "Positive %": 0.9004, + "Num Positive per mm^2": 78.87 + } +} \ No newline at end of file diff --git a/359/InvasionFront_CD8_block2_x6_y4_patient359_1.json b/359/InvasionFront_CD8_block2_x6_y4_patient359_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fadb7519c9743f3c73d28d3103b6675eb0c903c8 --- /dev/null +++ b/359/InvasionFront_CD8_block2_x6_y4_patient359_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20314.2, + "Centroid Y µm": 11194.1, + "Num Detections": 21964, + "Num Negative": 15181, + "Num Positive": 6783, + "Positive %": 30.88, + "Num Positive per mm^2": 3011.0 + } +} \ No newline at end of file diff --git a/359/TumorCenter_CD3_block2_x5_y4_patient359_0.json b/359/TumorCenter_CD3_block2_x5_y4_patient359_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b1e6c0a443e7c217b0b5f0f8cca7c6b681cefed0 --- /dev/null +++ b/359/TumorCenter_CD3_block2_x5_y4_patient359_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16666.2, + "Centroid Y µm": 9794.8, + "Num Detections": 22145, + "Num Negative": 18352, + "Num Positive": 3793, + "Positive %": 17.13, + "Num Positive per mm^2": 1532.6 + } +} \ No newline at end of file diff --git a/359/TumorCenter_CD3_block2_x6_y4_patient359_1.json b/359/TumorCenter_CD3_block2_x6_y4_patient359_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b5c9479c4744a518a6da18b59aca11490f8f80fc --- /dev/null +++ b/359/TumorCenter_CD3_block2_x6_y4_patient359_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19264.8, + "Centroid Y µm": 9919.7, + "Num Detections": 16950, + "Num Negative": 15766, + "Num Positive": 1184, + "Positive %": 6.985, + "Num Positive per mm^2": 606.69 + } +} \ No newline at end of file diff --git a/359/TumorCenter_CD8_block2_x5_y4_patient359_0.json b/359/TumorCenter_CD8_block2_x5_y4_patient359_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3713d1c275c6ea8325c7a97b9f4cca047f47e006 --- /dev/null +++ b/359/TumorCenter_CD8_block2_x5_y4_patient359_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18090.4, + "Centroid Y µm": 9420.0, + "Num Detections": 22339, + "Num Negative": 19246, + "Num Positive": 3093, + "Positive %": 13.85, + "Num Positive per mm^2": 1337.6 + } +} \ No newline at end of file diff --git a/359/TumorCenter_CD8_block2_x6_y4_patient359_1.json b/359/TumorCenter_CD8_block2_x6_y4_patient359_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2dc7dcfa77e1ec20ee11f9bbec55e149fe8d5450 --- /dev/null +++ b/359/TumorCenter_CD8_block2_x6_y4_patient359_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20739.0, + "Centroid Y µm": 9420.0, + "Num Detections": 17839, + "Num Negative": 17025, + "Num Positive": 814, + "Positive %": 4.563, + "Num Positive per mm^2": 399.66 + } +} \ No newline at end of file diff --git a/359/history_text.txt b/359/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a9e9ef739aa8b7ce62430010bc21696c8b6f2e80 --- /dev/null +++ b/359/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma G3 from the area of the glossoalveolar groove transition to the base of the tongue. Patient now scheduled for resection of the tumor and neck dissection with clinical plus neck on the right. \ No newline at end of file diff --git a/359/icd_codes.txt b/359/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/359/ops_codes.txt b/359/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1cebfde0a624e2f024dce165f40b118b16844b2a --- /dev/null +++ b/359/ops_codes.txt @@ -0,0 +1 @@ +Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/359/patient_clinical_data.json b/359/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6faa2fbada74e755f5aa3c5e875c82599f618257 --- /dev/null +++ b/359/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 32, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/359/patient_pathological_data.json b/359/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2e928059e2bca56d9836b4e562aee794ec3ee986 --- /dev/null +++ b/359/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "359", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 9.0, + "number_of_resected_lymph_nodes": 17, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/359/surgery_description.txt b/359/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7ab89875c81a55d37f8326fe76f66a6716a1a5c2 --- /dev/null +++ b/359/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Tracheotomy with mucocutaneous anastomosis diff --git a/359/surgery_report.txt b/359/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..af4c6148877ef3a230129019c8b35c506f2e6036 --- /dev/null +++ b/359/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy and laryngoscopy: After reclination of the head and insertion of the mouth guard, insertion of the small bore tube size C and B. The described tumor, previously described as cT1, is seen in the area of the glossoalveolar groove/base of tongue junction. Tumor is exulcerated. Further examination reveals an uneven mucosa in the area of the vallecula transition lingual epiglottis. A sample is taken here, which is sent for frozen section. The frozen section shows squamous cell carcinoma. Thus somewhat more extensive growth than known. Now adjustment of the tumor. Laser resection with 4 to 12 watts. Resection is now performed around the tumor with a safety margin of at least 1 cm on all sides. Resection proceeds from the lateral pharyngeal wall via the base of the tongue to the vallecula area to the left until microscopically healthy mucosa appears. Laterally, the resection goes into the pharyngeal muscle. Infiltrative growth is clearly visible here, so that the soft tissue, especially in the base of the tongue, must be resected more deeply. Resection extends to the hyoid bone. Caudally, the resection extends into the piriform sinus. Laterally to the edge of the left vallecula, it also includes the entire part of the lingual mucosa of the epiglottis and the caudal base of the tongue. The specimen is thread-marked for frozen section. There are still infiltrates caudally in the direction of the piriform sinus and laterally to the left in the direction of the vallecula. After consultation with the pathologists, no tumor infiltrates. At the same time, a marginal sample taken from the base of the tongue was unremarkable, as was the mucosa taken from the lingual epiglottis on the left. Thus, tumor infiltrates of the marginal sample of the left lateral vallecula, which was thread-marked, and the marginal sample of the caudal piriform sinus and, after evaluation of the tumor specimen, laterally towards the pharyngeal wall. Therefore, another extensive resection of the mucosal tissue from the left vallecula to the left pharyngeal wall was performed. Subsequently, a marginal sample is taken at the transition from the epiglottis to the left pharyngeal wall, which is also thread-marked for the frozen section. No more infiltrates here. The tonsil blocker is then inserted and an extensive resection is performed from the base of the tongue via the tonsil lobe to the lateral palatal arch. A strip of mucosa measuring at least 1 to 1.5 cm is resected here. Then a lateral margin sample is taken, which is marked with a thread. This marginal sample is also tumor-free. A resection is then performed from the caudal area or the piriform sinus, at least 1 to 1.5 cm wide. Then a marginal sample is taken from the caudal area or piriform sinus. This shows tumor infiltrates in the frozen section, whereby the tumor does not grow in the mucosa but in the underlying muscle layer. The right basal margin sample was tumor-free. The overall picture is that of a very extensive G3 squamous cell carcinoma growing like a sheet, which has grown into the soft tissue anteriorly towards the hyoid bone and in particular has undermined the mucosa and grown caudally into the piriform sinus and cannot be resected R0 from transorally. Overall, a wallpaper-like or mosaic-like, flat growth. Due to the overall situation, initial indication for tracheostomy. This is performed by and . () Tracheotomy: Now transition to tracheotomy. Injection of local anesthetic and sterile draping in the usual manner. Then mark the important landmarks and make the skin incision just below the cricoid cartilage. Dissection under bipolar coagulation through the cutaneous fatty tissue. Exposure of the straight neck muscles and transection in the linea alba. Push the muscles laterally. Subsequent careful dissection of the cricoid cartilage. This works well. Now undermine the thyroid isthmus and coagulate the isthmus in detail and carefully cut through it. Exposure of the cricoid cartilage and the trachea. This is also successful. Therefore, incision between the 2nd and 3rd tracheal clasp and suturing of the skin cranially and caudally. Then carefully withdraw the tube and insert the tracheal cannula. This is successful without any further problems. The tube is then removed in the usual manner. Then re-inspection of the oropharynx and extensive coagulation in the resection area by and . Ultimately, many isolated bleedings can still be stopped. Termination of the procedure without bleeding, without complications. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Overall, very extensive growth of a G3 squamous cell carcinoma, mainly extensive and undermining the mucosa, partly also extending into the soft tissue. Due to the overall situation, it is highly questionable whether extensive surgery, especially from the outside, is advisable, as the entire hypopharynx may fall and a flap plasty may occur, resulting in significant dysphagia. Dysphagia is pre-programmed anyway due to the extensive laser resection, hence tracheotomy. Neck dissection should be performed in the interval after approx. 10 to 14 days, which was no longer performed due to the resection of the pharynx from the inside. Finally, after neck dissection, indication for radiochemotherapy. \ No newline at end of file diff --git a/360/InvasionFront_CD8_block3_x3_y12_patient360_0.json b/360/InvasionFront_CD8_block3_x3_y12_patient360_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b3cd8123a123b3b7f15dc51317a2389a4215bd86 --- /dev/null +++ b/360/InvasionFront_CD8_block3_x3_y12_patient360_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12168.6, + "Centroid Y µm": 29509.4, + "Num Detections": 21953, + "Num Negative": 19524, + "Num Positive": 2429, + "Positive %": 11.06, + "Num Positive per mm^2": 1063.0 + } +} \ No newline at end of file diff --git a/360/InvasionFront_CD8_block3_x4_y12_patient360_1.json b/360/InvasionFront_CD8_block3_x4_y12_patient360_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9caf8643c11886e7ff4c0538c1cedb134d96be6d --- /dev/null +++ b/360/InvasionFront_CD8_block3_x4_y12_patient360_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14770.5, + "Centroid Y µm": 29581.1, + "Num Detections": 18915, + "Num Negative": 16939, + "Num Positive": 1976, + "Positive %": 10.45, + "Num Positive per mm^2": 904.21 + } +} \ No newline at end of file diff --git a/360/TumorCenter_CD3_block3_x3_y12_patient360_0.json b/360/TumorCenter_CD3_block3_x3_y12_patient360_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f07246ae8305c353e001292e18de45e8f78b3c49 --- /dev/null +++ b/360/TumorCenter_CD3_block3_x3_y12_patient360_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9937.6, + "Centroid Y µm": 36055.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/360/TumorCenter_CD3_block3_x4_y12_patient360_1.json b/360/TumorCenter_CD3_block3_x4_y12_patient360_1.json new file mode 100644 index 0000000000000000000000000000000000000000..543460dee986a1befbc0fa3ddcaa95fc5e6abfdf --- /dev/null +++ b/360/TumorCenter_CD3_block3_x4_y12_patient360_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12641.9, + "Centroid Y µm": 36198.0, + "Num Detections": 20367, + "Num Negative": 13374, + "Num Positive": 6993, + "Positive %": 34.33, + "Num Positive per mm^2": 3142.7 + } +} \ No newline at end of file diff --git a/360/TumorCenter_CD8_block3_x3_y12_patient360_0.json b/360/TumorCenter_CD8_block3_x3_y12_patient360_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba57e836e7b2b2a6e4111efb745b0a8c9e416a20 --- /dev/null +++ b/360/TumorCenter_CD8_block3_x3_y12_patient360_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10430.4, + "Centroid Y µm": 30819.1, + "Num Detections": 14738, + "Num Negative": 13243, + "Num Positive": 1495, + "Positive %": 10.14, + "Num Positive per mm^2": 871.63 + } +} \ No newline at end of file diff --git a/360/TumorCenter_CD8_block3_x4_y12_patient360_1.json b/360/TumorCenter_CD8_block3_x4_y12_patient360_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b7fefac7050e08ec7951207404f4c1464bd5ab85 --- /dev/null +++ b/360/TumorCenter_CD8_block3_x4_y12_patient360_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12968.1, + "Centroid Y µm": 30983.6, + "Num Detections": 21227, + "Num Negative": 18230, + "Num Positive": 2997, + "Positive %": 14.12, + "Num Positive per mm^2": 1397.9 + } +} \ No newline at end of file diff --git a/360/history_text.txt b/360/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..898a844d6f993f4f170f4321e4bad956ba875710 --- /dev/null +++ b/360/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma in the tonsil and lateral wall of the oropharynx. The above-mentioned surgery was therefore indicated. \ No newline at end of file diff --git a/360/icd_codes.txt b/360/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f5d957a2ba16beb28308dbe48a740588ebef1f4f --- /dev/null +++ b/360/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Gaumenbogen (vorderer) (hinterer)[C09.1 ] \ No newline at end of file diff --git a/360/ops_codes.txt b/360/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f3d299a36d9d0ba5194e09e3bb5653447325cdd6 --- /dev/null +++ b/360/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Sonstige partielle Glossektomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.x2 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Kopf und Hals[5-858.70 L] Unterarm[5-858.23 L] Mikrochirurgische Technik[5-984 ] Revision einer Blutgefäßoperation: Wechsel eines vaskulären Implantates[5-394.3 ] Revision einer Blutgefäßoperation: Wechsel eines vaskulären Implantates[5-394.3 ] Revision einer Blutgefäßoperation: Wechsel eines vaskulären Implantates[5-394.3 ] Freie Hauttransplantation, Entnahmestelle: Spalthaut: Oberschenkel und Knie[5-901.0e R] Freie Hauttransplantation, Empfängerstelle: Spalthaut, großflächig: Unterarm[5-902.48 L] \ No newline at end of file diff --git a/360/patient_clinical_data.json b/360/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e9d313fe57631d7970c7a245c9a4f60f0068d410 --- /dev/null +++ b/360/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 74, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/360/patient_pathological_data.json b/360/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..60b539e40957961607c10356e432053cb98f9d18 --- /dev/null +++ b/360/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "360", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 54, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/360/surgery_description.txt b/360/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..92cc01e8af7e96ad182753a978cb1fae4035f2c2 --- /dev/null +++ b/360/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheostomy creation diff --git a/360/surgery_report.txt b/360/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0f61f1f77fc157fe0b91a08c83e8b214f2153390 --- /dev/null +++ b/360/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again. Insertion of the McIvor blade. Inspection of the tumor. This extends from next to the uvula over the tonsil and lateral pharynx area to the base of the tongue. Placement of the PEG: insertion of the esophagoscope. After creating the diaphanoscopy, insertion of a 15 mm abdominal wall tube in a typical manner without complications. Fixation to the abdominal wall typically without any problems. First start with tumor removal transorally: tumor is incised on all sides with a safety margin of at least 1 to 1.5 cm and is extirpated in toto. The soft palate up to the uvula, the tonsil and adjacent pharyngeal side wall as well as the caudal mucosa up to the hypopharyngeal junction or the junction at the base of the tongue are removed. Tumor is thread-marked. Basally another marginal sample. In the frozen section in all directions in healthy tissue, except caudally, where there is still growth under the epithelium in the soft tissue. Therefore, resection from the outside is indicated. The patient is now positioned and all relevant surgical areas are disinfected. First neck dissection on the left: Skin incision in typical manner. Exposure of the sternocleidomastoid muscle, omohyoid muscle and digastric muscle. Exposure of the submandibular gland. Exposure of the internal jugular vein, facial vein, internal/external carotid artery. Exposure and preservation of hypoglossal nerve and vagus nerve. Clearing out levels II to V while preserving the branches of the cervical plexus. Subsequent transection and removal of the digastric muscle. Removal of the submandibular gland. Skeletonization of the hypoglossal nerve again. Exposure of the facial artery up to the exit from the area of the lingofacial trunk. The lingual artery is severed and struck caudally with the facial artery. Now overview of the tumor with defect in the pharyngeal space. Extensive resection of the soft tissue in the caudal margin of the former tumor, whereby the hyoid bone, superior cornu and parts of the external musculature around the hyoid bone are also resected up to the beginning of the vallecula. Subsequently, extensive marginal sampling of the mucosa caudally from the pharyngeal wall over the piriform sinus to the arytenoid region, with soft tissue underneath and with preservation of the superior laryngeal nerve. In addition, extensive soft tissue resection in the area of the vallecula. The latter two go to the frozen section. No more tumor infiltrates, thus R0 situation. Definitive indication for defect coverage using a radial flap. Neck dissection on the right by : Marking of the skin incision in consultation with . Incision of the cutaneous and subcutaneous tissue. Incision of the platysma with protection of the external jugular vein and the auricular nerve. Attachment of the upper edge of the platysma and subplatysmal dissection approx. 1.5 cm cranially until the submandibular gland is exposed. Open the glandular capsule and elevate the capsule to protect the marginal nerve. Attachment of the lower platysma margin and subplatysmal dissection approx. 1 cm caudally. Exposure of the anterior margin of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Dissection of the omohyoid muscle up to the hyoid bone. Exposure of the posterior venter of the digastric muscle and dissection along the muscle ventrally to the hyoid bone. Dissection along the sternocleidomastoid muscle in depth to the cervical plexus. Division of the neck preparation from caudal to cranial along the internal jugular vein. Identification of the hypoglossal nerve and the accessorius nerve. The neck preparation (lateral) is detached from the deep cervical fascia from cranial to caudal. Care is taken to spare the branches of the cervical plexus and the accessory nerve. The common carotid artery and the vagus nerve are exposed. All structures can be preserved. Overall, regions Ib to IV are included in the neck preparation. After removal of the lateral preparation, the medial preparation is now prepared and removed. The branches of the external carotid artery can be left intact. Irrigation of the wound with hydrogen and Ringer's solution. Overall, the wound is completely dry. Placement of a 10-gauge Redon drain and two-layer wound closure with a platysma and skin suture. Tracheostoma creation by : Transition to tracheostomy. A skin incision is made 1.5 QF below the thyroid cartilage. Careful dissection up to the trachea with careful hemostasis. Transverse incision of the trachea between two cartilages while protecting the tracheal tube. The operation is now briefly interrupted to suture in the flap. This is performed by . Subsequent mobilization of the subcutaneous tissue and mucocutaneous epithelialization by . The radialis flap is now elevated from the left forearm. Mark the size of the flap on the forearm approx. 9 x 6 cm. First cut around the flap from the ulnar side. Extend the incision towards the crook of the elbow. Exposure and preservation of the superficial venous system. Subsequent subfascial elevation of the flap from the radial side. Exposure and preservation of the lateral antebrachial cutaneous nerve. Exposure of the radial artery caudally. This is first clamped off. Flap is further elevated subfascially from ulnar and radial. The vascular pedicle is exposed up to the elbow. Connection between superficial and deep venous system is visualized. Venous outlets from the superficial venous system can be visualized. The radial artery is then severed and treated using 4.0 Prolene single button sutures using the puncture technique. Hand always well perfused up to this point, saturation at 100 %. Lifting of the flap subfascially. Smaller vessels are ligated or clipped or treated bipolarly. Lift up to the elbow area, here the radial artery and the vein of the deep venous system can be visualized. These are relatively small. However, there are 3 large veins of the superficial venous system, which are connected to the deep venous system. The flap is then removed. Veins are ligated. The brachial artery is supplied by puncture ligation. The flap is then flushed with heparin solution and preserved. Transition to defect coverage with . Marking of the graft. Cut around the graft and make a curved skin incision up to the elbow. Exposure of the brachioradialis muscle. Exposure of the cephalic vein and the outlets in the superficial system. Visualization of the venous confluence. Exposure of the superficial ramus of the radial nerve, which is spared. Exposure of the radial artery. Separation and transection of the radial artery. Lifting of the radial artery graft from the tendon bed and dissection of the pedicle up to the elbow. Removal of the pedicle while preserving the interosseous artery and the ulnar artery. One vein is lifted from the deep system and two veins from the superficial system. Suturing of the arm in the usual manner with coverage by split skin from the right thigh. Application of a dorsal forearm splint. Suturing of the graft largely from the transcervical side. Start suturing in the piriform sinus, then in the vallecula, then on the lateral pharyngeal wall and the last part transorally in the area of the soft palate and the edge of the tongue. The stalk is diverted to the left and connected to the lingual artery and the facial vein, the external jugular vein and another branch from the internal jugular vein. This means that a triple venous anastomosis and a single arterial anastomosis were performed. Insertion of a Redon drainage. Two-layer wound closure. Patient goes to the intensive care unit for postoperative monitoring. Antibiotics, which were started intraoperatively with Unacid, should be continued for 1 week. Control of the radial flap in a typical manner for 5 days according to the scheme. Continue herparin perfusor 500 units per hour for 5 days. Feeding via the inserted PEG tube. After 10 days, swallow porridge, then build up diet if necessary. Wait for the final histology and then presentation at the interdisciplinary tumor conference to plan further adjuvant therapy. \ No newline at end of file diff --git a/361/InvasionFront_CD3_block5_x3_y2_patient361_0.json b/361/InvasionFront_CD3_block5_x3_y2_patient361_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9e0b65609ea02b099d20ad4105eed33ea0a88db3 --- /dev/null +++ b/361/InvasionFront_CD3_block5_x3_y2_patient361_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 5022.3, + "Num Detections": 21124, + "Num Negative": 19643, + "Num Positive": 1481, + "Positive %": 7.011, + "Num Positive per mm^2": 602.29 + } +} \ No newline at end of file diff --git a/361/InvasionFront_CD3_block5_x4_y2_patient361_1.json b/361/InvasionFront_CD3_block5_x4_y2_patient361_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8b66ec44f551a7aeee454719443ff6871936b70b --- /dev/null +++ b/361/InvasionFront_CD3_block5_x4_y2_patient361_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13967.6, + "Centroid Y µm": 5047.3, + "Num Detections": 25266, + "Num Negative": 22188, + "Num Positive": 3078, + "Positive %": 12.18, + "Num Positive per mm^2": 1211.4 + } +} \ No newline at end of file diff --git a/361/InvasionFront_CD8_block5_x3_y2_patient361_0.json b/361/InvasionFront_CD8_block5_x3_y2_patient361_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c45260f81351c61b8b8b664d03a917f0c3f10369 --- /dev/null +++ b/361/InvasionFront_CD8_block5_x3_y2_patient361_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 5222.2, + "Num Detections": 21671, + "Num Negative": 20378, + "Num Positive": 1293, + "Positive %": 5.966, + "Num Positive per mm^2": 537.45 + } +} \ No newline at end of file diff --git a/361/InvasionFront_CD8_block5_x4_y2_patient361_1.json b/361/InvasionFront_CD8_block5_x4_y2_patient361_1.json new file mode 100644 index 0000000000000000000000000000000000000000..976a437baa8d3924beb225854c5521bbdb15c9aa --- /dev/null +++ b/361/InvasionFront_CD8_block5_x4_y2_patient361_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 5122.3, + "Num Detections": 23887, + "Num Negative": 21987, + "Num Positive": 1900, + "Positive %": 7.954, + "Num Positive per mm^2": 829.25 + } +} \ No newline at end of file diff --git a/361/TumorCenter_CD3_block5_x3_y2_patient361_0.json b/361/TumorCenter_CD3_block5_x3_y2_patient361_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bccd156628f1b69864a9602bbe36dcb028e656ab --- /dev/null +++ b/361/TumorCenter_CD3_block5_x3_y2_patient361_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13068.1, + "Centroid Y µm": 5047.3, + "Num Detections": 22868, + "Num Negative": 19618, + "Num Positive": 3250, + "Positive %": 14.21, + "Num Positive per mm^2": 1361.6 + } +} \ No newline at end of file diff --git a/361/TumorCenter_CD3_block5_x4_y2_patient361_1.json b/361/TumorCenter_CD3_block5_x4_y2_patient361_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5de932c1ce234fd35afd9eac8e7680d1a1bc8751 --- /dev/null +++ b/361/TumorCenter_CD3_block5_x4_y2_patient361_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15541.8, + "Centroid Y µm": 5272.2, + "Num Detections": 20618, + "Num Negative": 16935, + "Num Positive": 3683, + "Positive %": 17.86, + "Num Positive per mm^2": 1532.0 + } +} \ No newline at end of file diff --git a/361/TumorCenter_CD8_block5_x3_y2_patient361_0.json b/361/TumorCenter_CD8_block5_x3_y2_patient361_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eb12d962a61e719112631b78c1b3b734e2af04fc --- /dev/null +++ b/361/TumorCenter_CD8_block5_x3_y2_patient361_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11468.9, + "Centroid Y µm": 5022.3, + "Num Detections": 22016, + "Num Negative": 19988, + "Num Positive": 2028, + "Positive %": 9.211, + "Num Positive per mm^2": 870.53 + } +} \ No newline at end of file diff --git a/361/TumorCenter_CD8_block5_x4_y2_patient361_1.json b/361/TumorCenter_CD8_block5_x4_y2_patient361_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4593d3fb356ec0c676d09b5e914a7df59cee28a7 --- /dev/null +++ b/361/TumorCenter_CD8_block5_x4_y2_patient361_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13967.6, + "Centroid Y µm": 5047.3, + "Num Detections": 20842, + "Num Negative": 17448, + "Num Positive": 3394, + "Positive %": 16.28, + "Num Positive per mm^2": 1403.1 + } +} \ No newline at end of file diff --git a/361/history_text.txt b/361/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b2c37b705fa2a5ebf47dae00fc35f7f8556979cd --- /dev/null +++ b/361/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed oropharyngeal carcinoma (non-cornifying G3 squamous cell carcinoma, p16-positive). The surgical procedure was discussed in the tumor conference. The tumor volume is too large for primary radiochemotherapy. The patient had ample opportunity to inform himself about the procedure, was given detailed information and agreed to the operation. \ No newline at end of file diff --git a/361/icd_codes.txt b/361/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adc050c8f628f1e558c676f540ed678cb6876eb8 --- /dev/null +++ b/361/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/361/ops_codes.txt b/361/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4e9fc5953913bc43765831b01cd1be43abfe16f0 --- /dev/null +++ b/361/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie mit Rekonstruktion Sonstige[5-295.1x ] Sonstige partielle Glossektomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.x2 ] Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Temporäre Tracheotomie[5-311.0 ] Sonstige perkutan-endoskopisch Gastrostomie (PEG)[5-431.2x ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/361/patient_clinical_data.json b/361/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9c34717d6ef071f1da99d7e159b27bc8fb47b85a --- /dev/null +++ b/361/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/361/patient_pathological_data.json b/361/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6d53d527b442a321259633153762ea07d1f8b483 --- /dev/null +++ b/361/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "361", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 34, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/361/surgery_description.txt b/361/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..59a14a5b8cb93f228c3b3aa3fae464d7d0eb4f98 --- /dev/null +++ b/361/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheostomy creation, PEG placement, Defect coverage, Free flap (Radial) diff --git a/361/surgery_report.txt b/361/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..af5ac24f6778330bdbc10c7048c14f00f8857878 --- /dev/null +++ b/361/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Induction of anesthesia. Transoral intubation by the anesthesia colleagues. Entry with the flexible gastroesophagoscope. Pre-viewing into the stomach. If the diaphanoscopy is good, a PEG is placed using the thread pull-through method. Application of a wound dressing. This is done without any problems. Sterile washing and draping. Perform the tracheostomy in the usual way. For this, vertical skin incision below the cricoid cartilage. Exposure of the musculature. Split the muscles in the median line and expose the thyroid isthmus. Dissection of the thyroid isthmus and exposure of the anterior wall of the trachea. Insertion between the 2nd and 3rd tracheal cartilage. Creation of a visor tracheotomy. Creation of a mucocutaneous anastomosis and transfer to an LE tube. Then positioning of the patient. Sterile draping of all relevant areas. Start with neck dissection on the right: skin incision in typical manner. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid and digastric muscles. Exposure of the internal jugular vein, facial vein, external jugular vein. Visualization of the internal/external carotid artery, superior thyroid artery, facial artery and lingual artery. Exposure of the hypoglossal nerve, vagus nerve, accessorius nerve and various branches of the cervical plexus. Displacement and, at the end of the operation, re-embedding of the hypoglossal nerve, vagus nerve, accessorius nerve and the branches of the cervical plexus in the sense of neurolysis. Clearing of the lymph nodes. There are positive lymph nodes in the level II area, which means that level II to V are cleared. Here too, several suspicious, slightly enlarged lymph nodes in the lower area. Insertion of a Redon drain. Two-layer wound closure. Application of a pressure bandage. Insertion of a McIvor mouth blocker and inspection of the tumor region. The tumor originates from the left tonsil and spreads to the soft palate on the left side and infiltrates the anterior and posterior palatal arch. The uvula is not affected. However, the tumor extends to the base of the uvula. The tumor extends caudally into the glossotonsillar groove and infiltrates the base of the tongue on the left side. Subsequently, combined transoral-transcervical tumor resection: First cut through the digastric muscle. Removal of the submandibular gland. The duct is ligated. The lingual nerve is initially preserved from the caudal side. The facial artery is exposed up to the top and left intact. Pharyngeal wall is dissected away from the vessels, vessels are dissected away from the pharyngeal wall using vessel loops. The tumor is then resected under internal and external control with a safety margin of at least 1.5 cm on all sides. The entire pharyngeal wall is removed. Resection extends cranially including the palatal arch and the soft tissue of the pterygoid muscles up to the hypopharyngeal entrance, laterally up to the alveolar ridge or mandible. The lingual nerve cannot be preserved due to the extent of the tumor and must also be resected. Resection extends forward to the floor of the mouth. The entire specimen is removed and marked with sutures. Additional marginal sample from the soft tissues superior basally. In the frozen section, both tumor and margin sample in healthy tissue. Thus R0 situation. Careful hemostasis. Measurement of the defect. This is approx. 11 x 8 cm. Neck dissection on the left. Skin incision in the usual manner on the anterior edge of the sternocleidomastoid muscle. Exposure of the sternocleidomastoid muscle. Exposure of the submandibular gland and the digastric muscle. Visualization of the omoyhoideus muscle. Exposure of the internal jugular vein. Dissection of the internal jugular vein. Dissection of the facial vein and the superior thyroid artery. Exposure of the accessorius nerve and hypoglossal nerve. Displacement and, at the end of the operation, re-embedding of the accessory nerve and hypoglossal nerve in the sense of a neurolysis. Removal of the neck preparation II a to V a while sparing the plexus branches and the cervical vessel sheath. Redon drainage. Two-layer wound closure. Application of a pressure bandage. Lifting of the radialis graft on the left forearm. To do this, the graft is first marked. Then the cephalic vein, radial artery and ulnar artery are marked. Incision of the skin. Exposure of the brachioradialis muscle. Exposure of the cephalic vein and the basilic vein. Exposure of the confluence between the deep and superficial venous system. Visualization of the superficial ramus, radial nerve. Exposure of the radial artery. Ligation and stitching of the radial artery. Separation of the radial artery. Lifting the graft from the tendon bed. Dissection of the pedicle up to the elbow and removal of the graft, leaving several venous outlets and preserving the interosseous artery. Marking of the radial artery. Flushing of the entire graft with heparin solution. Lifting of split skin on the right thigh and defect coverage on the left forearm. Sewing on swabs to establish contact between the split skin and the wound bed. Sterile wound dressing and application of a dorsal forearm splint. Insertion of the graft into the oral cavity and start suturing in the area of the soft palate. The graft fits in well. It lies loosely and is sutured in successively, partly around the teeth in the area of the alveolar ridge. In the base of the tongue, transoral suturing is not possible. Here, suturing must be continued transcervically. This is somewhat complicated due to the lack of visibility and swelling of the tongue. Finally, the graft can be sutured in completely. Finally, the oral cavity and pharynx area is filled with Ringer's solution. There is no secretion flowing into the neck area. Dissection of the facial vein, the external jugular vein and the superior thyroid artery as connecting vessels. In addition, an outlet is prepared on the facial artery for a third vein. Anastomosis of the arterial vessels and ultimately also the venous vessels. Unfortunately, even if venous return is initially very good, arterial perfusion still stops intraoperatively. The arterial anastomosis must therefore be reopened and it becomes apparent that an occlusion has occurred in the anastomosis area due to previous damage to the superior thyroid artery. The thyroid artery must be cut back until there is no longer so much arteriosclerotic plaque material in the vessel. However, there is also previous damage here and the arterial anastomosis must again be performed very carefully. The graft is now permanently well perfused and a Redon drain is inserted. Two-layer wound closure. Final consultation with the anesthetist. The patient is ventilated in the intensive care unit and should receive antibiotics for at least 24 hours. Usual flap checks. \ No newline at end of file diff --git a/362/InvasionFront_CD3_block13_x1_y2_patient362_0.json b/362/InvasionFront_CD3_block13_x1_y2_patient362_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6cac4355f6234dcd9569197c50fda47dada1599c --- /dev/null +++ b/362/InvasionFront_CD3_block13_x1_y2_patient362_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3823.0, + "Centroid Y µm": 4672.5, + "Num Detections": 19841, + "Num Negative": 19644, + "Num Positive": 197, + "Positive %": 0.9929, + "Num Positive per mm^2": 84.46 + } +} \ No newline at end of file diff --git a/362/InvasionFront_CD3_block13_x2_y2_patient362_1.json b/362/InvasionFront_CD3_block13_x2_y2_patient362_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3cd7409a375b6507e4fc97caf5dd314a07d3351e --- /dev/null +++ b/362/InvasionFront_CD3_block13_x2_y2_patient362_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 4622.6, + "Num Detections": 12826, + "Num Negative": 12632, + "Num Positive": 194, + "Positive %": 1.513, + "Num Positive per mm^2": 116.63 + } +} \ No newline at end of file diff --git a/362/InvasionFront_CD8_block13_x1_y2_patient362_0.json b/362/InvasionFront_CD8_block13_x1_y2_patient362_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08903bca1e5a98e7d12fc6bc26bcdff66cb2f0ae --- /dev/null +++ b/362/InvasionFront_CD8_block13_x1_y2_patient362_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5347.2, + "Centroid Y µm": 5672.0, + "Num Detections": 22957, + "Num Negative": 21910, + "Num Positive": 1047, + "Positive %": 4.561, + "Num Positive per mm^2": 417.66 + } +} \ No newline at end of file diff --git a/362/InvasionFront_CD8_block13_x2_y2_patient362_1.json b/362/InvasionFront_CD8_block13_x2_y2_patient362_1.json new file mode 100644 index 0000000000000000000000000000000000000000..832f31dd583e4966c35e2a255b1b1274207c8c72 --- /dev/null +++ b/362/InvasionFront_CD8_block13_x2_y2_patient362_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7920.8, + "Centroid Y µm": 5796.9, + "Num Detections": 14865, + "Num Negative": 14457, + "Num Positive": 408, + "Positive %": 2.745, + "Num Positive per mm^2": 220.98 + } +} \ No newline at end of file diff --git a/362/TumorCenter_CD3_block13_x1_y2_patient362_0.json b/362/TumorCenter_CD3_block13_x1_y2_patient362_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cbfb203fb72f617c4c320b93744cfc5a86597900 --- /dev/null +++ b/362/TumorCenter_CD3_block13_x1_y2_patient362_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5547.1, + "Centroid Y µm": 10919.2, + "Num Detections": 29894, + "Num Negative": 29415, + "Num Positive": 479, + "Positive %": 1.602, + "Num Positive per mm^2": 171.75 + } +} \ No newline at end of file diff --git a/362/TumorCenter_CD3_block13_x2_y2_patient362_1.json b/362/TumorCenter_CD3_block13_x2_y2_patient362_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d8f177a48f0d8882b6c730d4454dabe4c0961f7e --- /dev/null +++ b/362/TumorCenter_CD3_block13_x2_y2_patient362_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8095.7, + "Centroid Y µm": 11194.1, + "Num Detections": 26816, + "Num Negative": 26374, + "Num Positive": 442, + "Positive %": 1.648, + "Num Positive per mm^2": 166.41 + } +} \ No newline at end of file diff --git a/362/TumorCenter_CD8_block13_x1_y2_patient362_0.json b/362/TumorCenter_CD8_block13_x1_y2_patient362_0.json new file mode 100644 index 0000000000000000000000000000000000000000..755967281e79c9b6199949f61ce9472ace7fea85 --- /dev/null +++ b/362/TumorCenter_CD8_block13_x1_y2_patient362_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 6421.6, + "Num Detections": 29056, + "Num Negative": 28045, + "Num Positive": 1011, + "Positive %": 3.479, + "Num Positive per mm^2": 365.51 + } +} \ No newline at end of file diff --git a/362/TumorCenter_CD8_block13_x2_y2_patient362_1.json b/362/TumorCenter_CD8_block13_x2_y2_patient362_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f0745240acd08f5b1455248325e251d113dd6c41 --- /dev/null +++ b/362/TumorCenter_CD8_block13_x2_y2_patient362_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 6146.7, + "Num Detections": 25412, + "Num Negative": 24293, + "Num Positive": 1119, + "Positive %": 4.403, + "Num Positive per mm^2": 424.6 + } +} \ No newline at end of file diff --git a/362/history_text.txt b/362/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..883762c171ee59e5d54f8d5841f8cf9d85f350eb --- /dev/null +++ b/362/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the left with invasion of the larynx on the left. A CT scan showed a herniated thyroid cartilage or herniation into the left laryngeal skeleton, therefore the above-mentioned operation was indicated. \ No newline at end of file diff --git a/362/icd_codes.txt b/362/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..622644b35931717c96ba26ff3b122113f06cc84b --- /dev/null +++ b/362/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/362/ops_codes.txt b/362/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6254c2d0e4a484fdb156a617e9f66a2786d2b2ad --- /dev/null +++ b/362/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 6 Regionen[5-403.22 B] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] Vollhautdeckung großflächig Empfängerstelle Unterarm[5-902.68 L] \ No newline at end of file diff --git a/362/patient_clinical_data.json b/362/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..517da081cf292126405d44260c7dfdb68dba02f9 --- /dev/null +++ b/362/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/362/patient_pathological_data.json b/362/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c1853ec0a0bff644374bd260593e59c06e472525 --- /dev/null +++ b/362/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "362", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 35, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/362/surgery_description.txt b/362/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6e40e3f1db1ad645d143355d442ec33c0e97f345 --- /dev/null +++ b/362/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy with subtotal pharyngectomy, Neck Dissection diff --git a/362/surgery_report.txt b/362/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f4f2b222f128ce5a2713f17222498cf37cfb5023 --- /dev/null +++ b/362/surgery_report.txt @@ -0,0 +1 @@ +First, laryngoscopy and pharyngoscopy again: The exophytic tumor is seen, which is located in the piriform sinus on the left, passes to the vallecula of the epiglottis and also grows into the larynx via the arytenoid fold. Transition also to the postcricoid region. Indication for surgery thus confirmed. Skin disinfection, injection of a total of 20 ml Ultracaine 1% with adrenaline in the area of the sides of the neck and sterile draping of all surgical areas. First, create an apron flap in the typical manner, subplatysmal to the level of the hyoid bone and submandibular gland. Then neck dissection on both sides, initially on the right: same procedure on both sides. Dissection of the lymph node packages from the sternocleidomastoid muscle. Exposure of the cervical vascular sheath, internal jugular vein, internal carotid artery, external carotid artery, vagus nerve, accessorius nerve, hypoglossal nerve. The lymph nodes are then removed from 2 to 5, followed by neck dissection on the left side in the same way. All structures are exposed and preserved as on the opposite side, including the superior thyroid artery. This is followed by laryngectomy with subtotal pharyngectomy: skeletonization of the larynx. Dissection of the suprahyoid muscles from the hyoid bone, which is removed due to the height of the tumor. Skeletonization of the grand......... on the right side and as far as possible on the left side. On the right, the constrictor pharyngeus is dissected from the laryngeal skeleton. This must be largely omitted on the left side, where the constrictor muscles are largely resected as well. Also resection of infrahyoid muscles and lymph nodes up to level VI. Entry into the larynx from the cranial paramedian on the right. Release of the epiglottis, exposure of the tumor. The tumor was previously operated on transorally from the cranial side and the cranial resection margin was marked. A marginal sample from the cranial resection area was in healthy tissue. The tumor is now resected on all sides with a safety margin of at least 1.5 to 2 cm, taking into account the cranial resection margins. Pharynx falls largely to the posterior wall on the left. The postcricoid region is also resected up to just in front of the esophageal entrance. The trachea had already been exposed previously. The lobes of the thyroid gland were clamped, severed and treated with puncture ligatures. The thyroid gland was pushed off caudo-laterally. The larynx was then removed, leaving the trachea extended cranially and dorsally. Then mark the laryngectomy and pharyngectomy specimen. A relatively wide marginal sample is taken from the left pharyngeal wall area and a marginal sample from the tongue base area. However, with free tumor margins around the tumor specimen, the margin sample, which was also taken from the pharyngeal wall area, still shows carcinoma in situ. This indicates discontinuous growth. The marginal sample from the base of the tongue was clear. Further resection in the entire pharyngeal wall area from caudal to cranial left. Removal of a representative marginal sample. This still shows moderate dysplasia. Thus overall R0 situation. No evidence of invasive carcinoma. A 2-4 cm strip of residual pharynx remains. Defect coverage using a radial flap is therefore necessary. The radial flap is removed from the left forearm. Mark the size of the flap, which is 15 x 8-9 cm. Create a tourniquet. Then lift the flap first from the ulnar side, from here extend the incision in the crook of the elbow. Subsequent mobilization of the flap from the radial side, including the superficial venous system and underneath the fascia. Exposure of the vascular pedicle below the brachioradialis muscle. Mobilization of the flap from below after the radial artery, which is supplied with blood by means of a tourniquet, has been removed. Successive elevation of the flap with clipping or bipolar supply of branches. The connection between the deep and superficial venous system is shown in the crook of the elbow. A total of 3 venous connections of the confluence or cephalic vein can be visualized. Good perfusion after opening the tourniquet. Flap remains in perfusion until the R0 situation is established. Then remove the flap. Ligatures in the area of the veins and puncture ligature with 4-0 prolene in the area of the artery shortly before entering the brachial artery. Remaining hand well perfused. Flap is flushed with heparin and preserved. A piece of full-thickness skin of the appropriate size is removed from the groin area in the typical manner. Here a groin after skin mobilization. Closure in layers using multi-layered subcutaneous sutures and back-stitch skin sutures after insertion of a Redon drain with relatively little tension. The forearm wound is closed in layers in the cranial area in a typical manner. The defect is now covered by the full-thickness skin graft and the full-thickness skin graft is successively incorporated here using 4-0 Ethilon sutures. A Hydrogel-Mebilex dressing is then applied. Application of loose compresses. Wrapping in absorbent cotton. Fitting of a Cramer splint and wrapping of the arm with an elastic bandage. Then cover the defect with a radial flap: Radialis flap is inserted into the defect and successively incorporated using 3-0 Vicryl single button sutures. Complete tension-free closure. Flap pedicle is transferred to the right side. After conditioning the vessels, first anastomosis of the radial artery with the superior thyroid artery using 8-0 Ehtilon single button sutures. After opening the clamps, good arterial flow and good venous return. The vein is confluent with the radial vein and is anastomosed with an outlet from the facial vein using a 2.5 mm coupler; good venous return also after opening the clamps. After conditioning, the cephalic vein is anastomosed with the external jugular vein using a 2.5 mm coupler; good venous flow can also be registered here. The residual veins are clipped and bipolized. Careful irrigation of the surgical site and hemostasis. Wound closure in layers with insertion of a Redon drain on both sides. Particularly deep fixation on the right in the anastomosis region. Trachea is epithelized in a typical manner. Finally, insertion of a 10 mm tracheal cannula which is fixed with sutures. No dressing. Patient goes to intensive care unit for postoperative monitoring. Please continue intraoperative therapy with heparin 500 E/hour for 5 days. Flap control by means of Doppler and clinically via laryngoscope insertion according to scheme. Please continue antibiotic therapy with Unacid, which was started intraoperatively, for at least 2 days. Nutrition via the previously inserted PEG tube for at least 10 days. Total cT4a cN2c hypopharyngeal carcinoma left. Discuss postoperative radiotherapy versus radiochemotherapy. \ No newline at end of file diff --git a/363/InvasionFront_CD3_block19_x5_y7_patient363_0.json b/363/InvasionFront_CD3_block19_x5_y7_patient363_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aec9b18eedf7a5d4fc1cb3f11f742cea8251acad --- /dev/null +++ b/363/InvasionFront_CD3_block19_x5_y7_patient363_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16716.1, + "Centroid Y µm": 20114.3, + "Num Detections": 21983, + "Num Negative": 21482, + "Num Positive": 501, + "Positive %": 2.279, + "Num Positive per mm^2": 204.12 + } +} \ No newline at end of file diff --git a/363/InvasionFront_CD3_block19_x6_y7_patient363_1.json b/363/InvasionFront_CD3_block19_x6_y7_patient363_1.json new file mode 100644 index 0000000000000000000000000000000000000000..61c8cd832f1851286e4c397b3647aa29eb46cf96 --- /dev/null +++ b/363/InvasionFront_CD3_block19_x6_y7_patient363_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19264.8, + "Centroid Y µm": 20339.2, + "Num Detections": 23813, + "Num Negative": 19691, + "Num Positive": 4122, + "Positive %": 17.31, + "Num Positive per mm^2": 1621.8 + } +} \ No newline at end of file diff --git a/363/InvasionFront_CD8_block19_x5_y7_patient363_0.json b/363/InvasionFront_CD8_block19_x5_y7_patient363_0.json new file mode 100644 index 0000000000000000000000000000000000000000..83dde69560e852b5c467ccc856c2e932d0e6e776 --- /dev/null +++ b/363/InvasionFront_CD8_block19_x5_y7_patient363_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 27610.4, + "Num Detections": 21715, + "Num Negative": 20547, + "Num Positive": 1168, + "Positive %": 5.379, + "Num Positive per mm^2": 547.59 + } +} \ No newline at end of file diff --git a/363/InvasionFront_CD8_block19_x6_y7_patient363_1.json b/363/InvasionFront_CD8_block19_x6_y7_patient363_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bbf882e0fcb134ee7a8dfb268ad9dfc097efb5cb --- /dev/null +++ b/363/InvasionFront_CD8_block19_x6_y7_patient363_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19214.8, + "Centroid Y µm": 27710.3, + "Num Detections": 18476, + "Num Negative": 17909, + "Num Positive": 567, + "Positive %": 3.069, + "Num Positive per mm^2": 296.85 + } +} \ No newline at end of file diff --git a/363/TumorCenter_CD3_block19_x5_y7_patient363_0.json b/363/TumorCenter_CD3_block19_x5_y7_patient363_0.json new file mode 100644 index 0000000000000000000000000000000000000000..13fbbefdb989004b19c35cc5250d4869f8bb1e5b --- /dev/null +++ b/363/TumorCenter_CD3_block19_x5_y7_patient363_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17465.8, + "Centroid Y µm": 17915.5, + "Num Detections": 25186, + "Num Negative": 22396, + "Num Positive": 2790, + "Positive %": 11.08, + "Num Positive per mm^2": 1054.6 + } +} \ No newline at end of file diff --git a/363/TumorCenter_CD3_block19_x6_y7_patient363_1.json b/363/TumorCenter_CD3_block19_x6_y7_patient363_1.json new file mode 100644 index 0000000000000000000000000000000000000000..27e0e38204d55da9c4f9867cf26ac2adb515f82e --- /dev/null +++ b/363/TumorCenter_CD3_block19_x6_y7_patient363_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19989.4, + "Centroid Y µm": 17665.6, + "Num Detections": 22711, + "Num Negative": 21315, + "Num Positive": 1396, + "Positive %": 6.147, + "Num Positive per mm^2": 607.58 + } +} \ No newline at end of file diff --git a/363/TumorCenter_CD8_block19_x5_y7_patient363_0.json b/363/TumorCenter_CD8_block19_x5_y7_patient363_0.json new file mode 100644 index 0000000000000000000000000000000000000000..20701a548cd81d52a2cc9f6406928734d2c2f9f5 --- /dev/null +++ b/363/TumorCenter_CD8_block19_x5_y7_patient363_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 28584.9, + "Num Detections": 23306, + "Num Negative": 20302, + "Num Positive": 3004, + "Positive %": 12.89, + "Num Positive per mm^2": 1219.8 + } +} \ No newline at end of file diff --git a/363/TumorCenter_CD8_block19_x6_y7_patient363_1.json b/363/TumorCenter_CD8_block19_x6_y7_patient363_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d577c9b27cb84788e5d6d61f66bd7c5cb40bd191 --- /dev/null +++ b/363/TumorCenter_CD8_block19_x6_y7_patient363_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21538.6, + "Centroid Y µm": 28684.8, + "Num Detections": 23424, + "Num Negative": 21596, + "Num Positive": 1828, + "Positive %": 7.804, + "Num Positive per mm^2": 771.56 + } +} \ No newline at end of file diff --git a/363/history_text.txt b/363/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/363/icd_codes.txt b/363/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..31f58876b28caf6583e662fc242ecb509734f250 --- /dev/null +++ b/363/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 L] \ No newline at end of file diff --git a/363/ops_codes.txt b/363/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..20a73f8675a0ec5bfc43700b6750ec11ec411ae0 --- /dev/null +++ b/363/ops_codes.txt @@ -0,0 +1 @@ +Endolaryngeale Chordektomie[5-302.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Biopsie an der Glottis durch Inzision[1-549.1 ] \ No newline at end of file diff --git a/363/patient_clinical_data.json b/363/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..68969259fe61420a65afe0dd7c8ceef7e5484867 --- /dev/null +++ b/363/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/363/patient_pathological_data.json b/363/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d8ce8a36c50d6cebb6d65c740f4a8c951dfce086 --- /dev/null +++ b/363/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "363", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/363/surgery_description.txt b/363/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..25af33c07b425f91e34f67ca527dc9ebd810eb79 --- /dev/null +++ b/363/surgery_description.txt @@ -0,0 +1 @@ +Laser partial chordectomy left, Panendoscopy diff --git a/363/surgery_report.txt b/363/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7b5aa426299e5672d8aa59afebfa0fba53ef17d --- /dev/null +++ b/363/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating room, induction of anesthesia by the anesthesia colleagues and performance of the team time-out. Positioning of the patient by the surgeon and start of the flexible esophagoscopy. This reveals normal, inconspicuous mucosa in the stomach and esophagus. A mass cannot be detected. Handover to and transition to microlaryngoendoscopy. First adjustment of the glottis using a Kleinsasser C-tube. A reddened and, especially in the middle third at the transition to the posterior third, thickened vocal fold without a larger, exophytic mass is seen on the left side. The laser-specific safety precautions were then carried out and the mucous membrane of the left vocal fold was removed using a CO2 laser to perform a partial chordectomy. Subsequently, removal of four marginal samples at the anterior and posterior end of the left vocal fold as well as cranially towards the sinus of Morgagni and caudally towards the subglottis. Sending the specimens for pathological examination. After monopolar coagulation and insertion of an Otriven-soaked swab, check the mucosal conditions again. Tooth status firm and idem, all swabs complete. Completion of the operation under dry wound conditions. Conclusion: The previously histologically confirmed squamous cell carcinoma of the left vocal fold appeared clinically macroscopically like a pT1a glottic carcinoma, no further tumorous infiltration was visible. Intraoperative administration of 250 mg SDH was performed. The further procedure is to be determined after receipt of the final histology and the findings from the margin samples. \ No newline at end of file diff --git a/364/InvasionFront_CD3_block22_x1_y1_patient364_0.json b/364/InvasionFront_CD3_block22_x1_y1_patient364_0.json new file mode 100644 index 0000000000000000000000000000000000000000..01df48240ea2c782580fd9036931973a04e4fa3b --- /dev/null +++ b/364/InvasionFront_CD3_block22_x1_y1_patient364_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5022.3, + "Centroid Y µm": 13717.7, + "Num Detections": 23627, + "Num Negative": 21783, + "Num Positive": 1844, + "Positive %": 7.805, + "Num Positive per mm^2": 782.32 + } +} \ No newline at end of file diff --git a/364/InvasionFront_CD3_block22_x2_y1_patient364_1.json b/364/InvasionFront_CD3_block22_x2_y1_patient364_1.json new file mode 100644 index 0000000000000000000000000000000000000000..463f5e12a1eee57b359343888ae9cb05b7ddf0b0 --- /dev/null +++ b/364/InvasionFront_CD3_block22_x2_y1_patient364_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7417.7, + "Centroid Y µm": 13536.8, + "Num Detections": 4007, + "Num Negative": 3881, + "Num Positive": 126, + "Positive %": 3.144, + "Num Positive per mm^2": 251.94 + } +} \ No newline at end of file diff --git a/364/InvasionFront_CD8_block22_x1_y1_patient364_0.json b/364/InvasionFront_CD8_block22_x1_y1_patient364_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5a2d5674523c359b0f263cf912a80e64d3cb3efe --- /dev/null +++ b/364/InvasionFront_CD8_block22_x1_y1_patient364_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 3373.2, + "Num Detections": 21759, + "Num Negative": 20881, + "Num Positive": 878, + "Positive %": 4.035, + "Num Positive per mm^2": 372.15 + } +} \ No newline at end of file diff --git a/364/InvasionFront_CD8_block22_x2_y1_patient364_1.json b/364/InvasionFront_CD8_block22_x2_y1_patient364_1.json new file mode 100644 index 0000000000000000000000000000000000000000..01af2973a9ad6186f4410a5aaf57820ae36d1b54 --- /dev/null +++ b/364/InvasionFront_CD8_block22_x2_y1_patient364_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9070.2, + "Centroid Y µm": 3248.3, + "Num Detections": 19304, + "Num Negative": 18820, + "Num Positive": 484, + "Positive %": 2.507, + "Num Positive per mm^2": 207.85 + } +} \ No newline at end of file diff --git a/364/TumorCenter_CD3_block22_x1_y1_patient364_0.json b/364/TumorCenter_CD3_block22_x1_y1_patient364_0.json new file mode 100644 index 0000000000000000000000000000000000000000..815a5f71dcc3a5f0add080730d4ce9ed44910a15 --- /dev/null +++ b/364/TumorCenter_CD3_block22_x1_y1_patient364_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4641.2, + "Centroid Y µm": 3711.9, + "Num Detections": 20366, + "Num Negative": 19683, + "Num Positive": 683, + "Positive %": 3.354, + "Num Positive per mm^2": 291.81 + } +} \ No newline at end of file diff --git a/364/TumorCenter_CD3_block22_x2_y1_patient364_1.json b/364/TumorCenter_CD3_block22_x2_y1_patient364_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ceb3ef6ad3f7ca799cd335a5315e575955b9eef0 --- /dev/null +++ b/364/TumorCenter_CD3_block22_x2_y1_patient364_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7171.2, + "Centroid Y µm": 3652.2, + "Num Detections": 21144, + "Num Negative": 20678, + "Num Positive": 466, + "Positive %": 2.204, + "Num Positive per mm^2": 194.91 + } +} \ No newline at end of file diff --git a/364/TumorCenter_CD8_block22_x1_y1_patient364_0.json b/364/TumorCenter_CD8_block22_x1_y1_patient364_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aa41ab2398678870c5a52b86fb4c21e0316e6441 --- /dev/null +++ b/364/TumorCenter_CD8_block22_x1_y1_patient364_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7146.2, + "Centroid Y µm": 12243.5, + "Num Detections": 20824, + "Num Negative": 19217, + "Num Positive": 1607, + "Positive %": 7.717, + "Num Positive per mm^2": 660.18 + } +} \ No newline at end of file diff --git a/364/TumorCenter_CD8_block22_x2_y1_patient364_1.json b/364/TumorCenter_CD8_block22_x2_y1_patient364_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6667e30fce6036eae4c326e90877daa965721c38 --- /dev/null +++ b/364/TumorCenter_CD8_block22_x2_y1_patient364_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9644.9, + "Centroid Y µm": 12418.4, + "Num Detections": 21454, + "Num Negative": 20358, + "Num Positive": 1096, + "Positive %": 5.109, + "Num Positive per mm^2": 447.73 + } +} \ No newline at end of file diff --git a/364/history_text.txt b/364/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/364/icd_codes.txt b/364/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8c9dbeb7107f1d282fbae4e77206bd04ea8548e0 --- /dev/null +++ b/364/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] Lymphknotenvergrößerung, nicht näher bezeichnet[R59.9 ] \ No newline at end of file diff --git a/364/ops_codes.txt b/364/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..af2368f7816f77c1fb6d686563c998d8c6cc40c2 --- /dev/null +++ b/364/ops_codes.txt @@ -0,0 +1 @@ +Klinische Untersuchung in Allgemeinanästhesie[1-100 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Exzision, mikrolaryngoskopisch[5-300.2 ] Andere partielle Laryngektomie: Endoskopische Laserresektion[5-302.5 ] Reoperation[5-983 ] Mikrochirurgische Technik[5-984 ] Lasertechnik[5-985 ] Permanente Tracheostomie: Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 4 Regionen[5-403.03 B] \ No newline at end of file diff --git a/364/patient_clinical_data.json b/364/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bc4866c089f1fcc0bc1e4cd28137058989e1adcc --- /dev/null +++ b/364/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2008, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 47, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/364/patient_pathological_data.json b/364/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4a47b477eb5b67076b62e5053566b11541cb0123 --- /dev/null +++ b/364/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "364", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/364/surgery_description.txt b/364/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..db573ee36f6bb6117f94e1b3bc4987f4e03ac6ec --- /dev/null +++ b/364/surgery_description.txt @@ -0,0 +1 @@ +Laser resection of tumor, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/364/surgery_report.txt b/364/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..19ab19dbe377be62500fb1a2dff8dec3b4430cbc --- /dev/null +++ b/364/surgery_report.txt @@ -0,0 +1 @@ +Before neck dissection and tracheotomy, laser resection of the T2 supraglottic carcinoma and PEG placement are performed first. PEG insertion first: The esophagoscope is inserted into the stomach without any problems. Inconspicuous conditions there. Good diaphanoscopy. Insertion of the PEG using the thread pull-through method in the usual way without complications. Now adjustment of the laryngeal entrance and the epiglottis with the spreading laryngoscope. A tumor can be seen on the laryngeal epiglottis, which, as described above, touches the aryepiglottic fold on the right, extends to the arytenoid cartilage and infiltrates into the pocket fold. In addition, the vocal fold is not fully reached on the right side. On the left, extending beyond the median line, moving towards the pocket fold, but clearly not reaching the vocal fold here. First of all, cutting around the entire epiglottis with the laser and partial resection of the upper and cranial part of the tumor. Resection anteriorly up to the pre-epiglottic fatty tissue. Splitting of the epiglottis attachment in the area of the petiolus and initial removal and resection of the tumor in the left larynx, up to the pocket crease, into the anterior commissure and into the pre-epiglottic fatty tissue. Resection clinically in healthy tissue. After resection of this part, incision of the aryepiglottic fold and insertion into the larynx. Resection of the entire pocket fold. Exposure of the thyroid cartilage and resection up to the vocal fold. The lower part of the vocal fold remains completely intact up to the anterior commissure at the transition to the left pocket fold. Finally, resection in the area of the right arytenoid. Another piece is removed here. Clinically now complete resection of the tumor. Thyroid cartilage partially exposed or still covered with perichondrium in some places. Circular margin samples are now taken, all of which are found to be tumor-free in the frozen section. An R0 resection can be assumed. Extensive hemostasis during the operation with repeated monopolar and bipolar coagulation. Finally, insertion of a swab with H2O2. This is removed again at the end of the operation. Repositioning of the patient and neck dissection with tracheotomy. Tumor resection was performed (previous procedure by ) Takeover now for neck dissection on both sides. Beginning on the right side: An existing old scar can be seen in the area of the larynx. This is also used for the incision. Therefore, an atypical incision is made here in order to take the old scar structure with it. Dissect down to the sternocleidomastoid. Locate the omohyoid muscle and digaster muscle as the upper and lower structure. Locate the accessorius nerve. Dissecting along the vein. Locating the vagus nerve. Removal of the lateral neck preparation. Now remove the medial neck preparation including the submandibular capsule. Locate and protect the hypoglossal nerve. Irrigation with hydrogen and Ringer. Insertion of a Redon drainage. Subcutaneous suture. Skin suture. Summary: Several suspicious lymph nodes, especially in region III. Now repositioning and start on the left side: Here now slightly similar incision as on the right in the area of the tension lines in order to maintain symmetry. Dissect down to the sternocleidomastoid muscle. Dissect down to the omohyoid and digaster. Locate the accessorius nerve. It can now be seen that the bulb of the carotid artery is located laterally, the vagus nerve is on the outside and the vein itself is located medially as a normal variant. Locate the hypoglossal nerve. This is also prominently exposed. The lateral neck preparation is now dissected out, possibly sparing the plexus branches, as on the right side. The medial parts of the neck and the submandibular capsule are also removed. Followed by hydrogen irrigation, Ringer irrigation. Insertion of a Redon drainage. Subcutaneous suture. Skin suture. Regio III/IV enlarged nodes also appeared on the left side. Now repositioning and tracheotomy: Kocher collar incision. Dissection down to the thyroid gland. Undermining of the same. Passing through the isthmus, repositioning. Formation of a Björk flap after entering the trachea. Suturing it to the skin. Skin suture. Then reintubation with an 8-gauge cannula. Now inspection of the laryngeal resection margin: Small hemorrhage in the anterior and lateral part. These are monopolar coagulated. No more bleeding afterwards. The inserted compress is removed and the procedure is completed. No bleeding at the end of the procedure, no complications. The previously performed measures are dictated separately by or . \ No newline at end of file diff --git a/365/InvasionFront_CD3_block16_x5_y6_patient365_0.json b/365/InvasionFront_CD3_block16_x5_y6_patient365_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cff6b3d0ab64b9a13ce77dedb95a55311ddea94f --- /dev/null +++ b/365/InvasionFront_CD3_block16_x5_y6_patient365_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16698.5, + "Centroid Y µm": 19648.9, + "Num Detections": 16424, + "Num Negative": 14395, + "Num Positive": 2029, + "Positive %": 12.35, + "Num Positive per mm^2": 947.24 + } +} \ No newline at end of file diff --git a/365/InvasionFront_CD3_block16_x6_y6_patient365_1.json b/365/InvasionFront_CD3_block16_x6_y6_patient365_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fc83d6dd712560e458171a45e2e99a0d875adeb6 --- /dev/null +++ b/365/InvasionFront_CD3_block16_x6_y6_patient365_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19169.3, + "Centroid Y µm": 19697.3, + "Num Detections": 15924, + "Num Negative": 14089, + "Num Positive": 1835, + "Positive %": 11.52, + "Num Positive per mm^2": 891.01 + } +} \ No newline at end of file diff --git a/365/InvasionFront_CD8_block16_x5_y6_patient365_0.json b/365/InvasionFront_CD8_block16_x5_y6_patient365_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b80716564620bb8050eb4c76b85fe65874d255ec --- /dev/null +++ b/365/InvasionFront_CD8_block16_x5_y6_patient365_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16061.7, + "Centroid Y µm": 14947.7, + "Num Detections": 17270, + "Num Negative": 15321, + "Num Positive": 1949, + "Positive %": 11.29, + "Num Positive per mm^2": 896.59 + } +} \ No newline at end of file diff --git a/365/InvasionFront_CD8_block16_x6_y6_patient365_1.json b/365/InvasionFront_CD8_block16_x6_y6_patient365_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bd5943894b78ff9673b16243b1eac1bdf129fe38 --- /dev/null +++ b/365/InvasionFront_CD8_block16_x6_y6_patient365_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18657.1, + "Centroid Y µm": 15023.2, + "Num Detections": 15255, + "Num Negative": 14192, + "Num Positive": 1063, + "Positive %": 6.968, + "Num Positive per mm^2": 556.72 + } +} \ No newline at end of file diff --git a/365/TumorCenter_CD3_block16_x5_y6_patient365_0.json b/365/TumorCenter_CD3_block16_x5_y6_patient365_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8c5575f1ad9512b1a77b6b5d22e504294dd31d19 --- /dev/null +++ b/365/TumorCenter_CD3_block16_x5_y6_patient365_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 15616.7, + "Num Detections": 6502, + "Num Negative": 4944, + "Num Positive": 1558, + "Positive %": 23.96, + "Num Positive per mm^2": 1723.2 + } +} \ No newline at end of file diff --git a/365/TumorCenter_CD3_block16_x6_y6_patient365_1.json b/365/TumorCenter_CD3_block16_x6_y6_patient365_1.json new file mode 100644 index 0000000000000000000000000000000000000000..91d158df13be795b9c96e5c72199e9b4ba03a9a0 --- /dev/null +++ b/365/TumorCenter_CD3_block16_x6_y6_patient365_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19564.6, + "Centroid Y µm": 15766.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/365/TumorCenter_CD8_block16_x5_y6_patient365_0.json b/365/TumorCenter_CD8_block16_x5_y6_patient365_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f5299a31192cd6eb73d569d7961f47e9efdc1d3f --- /dev/null +++ b/365/TumorCenter_CD8_block16_x5_y6_patient365_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 15541.8, + "Num Detections": 12791, + "Num Negative": 12124, + "Num Positive": 667, + "Positive %": 5.215, + "Num Positive per mm^2": 404.38 + } +} \ No newline at end of file diff --git a/365/TumorCenter_CD8_block16_x6_y6_patient365_1.json b/365/TumorCenter_CD8_block16_x6_y6_patient365_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9a0eeb7badb61dcc60829980f2d40114e90fc60d --- /dev/null +++ b/365/TumorCenter_CD8_block16_x6_y6_patient365_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18515.2, + "Centroid Y µm": 15566.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/365/history_text.txt b/365/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d78f352d64e747bf02054c5a55520c0e17aaf9de --- /dev/null +++ b/365/history_text.txt @@ -0,0 +1 @@ +The patient has a P16 negative G2 squamous cell carcinoma on the left. In the tumor conference, the decision was made to perform endoral tumor resection without flap plasty and neck dissection on both sides. \ No newline at end of file diff --git a/365/icd_codes.txt b/365/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b8bb53ea6db4bcb7c44e7b39b161463a30e7bf60 --- /dev/null +++ b/365/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Zunge mehrere Teilbereiche überlappend[C02.8 ] \ No newline at end of file diff --git a/365/ops_codes.txt b/365/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..07f93caafc643cfdb657f377bbe052a1595cbdcf --- /dev/null +++ b/365/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/365/patient_clinical_data.json b/365/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..43c1d0dc511b573e5796e033ea167ad4b8c6a408 --- /dev/null +++ b/365/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 42, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/365/patient_pathological_data.json b/365/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3af12e54337178f5ac2a5fed99f20e181a173ef5 --- /dev/null +++ b/365/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "365", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 38, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/365/surgery_description.txt b/365/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..784fd0197aa7d825150794ab3467804bbaf0253a --- /dev/null +++ b/365/surgery_description.txt @@ -0,0 +1 @@ +Partial tongue resection, Bilateral neck dissection, Tracheotomy diff --git a/365/surgery_report.txt b/365/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..da72f7d7f0c1f4a8d2335eefd0626a9b0bd32517 --- /dev/null +++ b/365/surgery_report.txt @@ -0,0 +1 @@ +Induction and intubation by the anesthetist. Positioning of the head and insertion of wound blocks in the oral cavity. Snaring of the tongue and exposure of the tumor. The tumor is endophytic on the left side of the tongue wall and grows to the midline at the base of the tongue. The tip of the tongue is free on both sides. First mark the edges of the incision using a monopolor needle. Now start the resection in the area of the raphe, in the middle of the tongue and in the posterior tongue area. Here, the raphe is moved strictly downwards. The tumor is palpated at a safe distance from the cutting edge. Further dissection with scissors and forceps. First resection of the medial part, carefully moving from the surface of the tongue downwards and then forwards towards the tip of the tongue. Hemostasis using bipolar coagulation. Now dissect the base of the tongue. Here too, use scissors, forceps and bipolar coagulation. The anterior palatal arch must also be partially resected as far as the mucosa is concerned. The tonsil is left in situ as it is not palpatorily infiltrated. Now dissect the outer edge of the tongue and proceed towards the tip of the tongue. The lingual artery is encountered. This is carefully coagulated and ligated. Expose the lingual nerve, which can be completely preserved. Further resection in the mucosal area of the floor of the mouth. The submandibular gland must be partially resected. The Wharton's duct can be identified and spared. Excision of the tumor with scissors and forceps under bipolar coagulation. Larger blood vessels are carefully coagulated and ligated. Further hemostasis using bipolar coagulation. The entire tumor preparation is thread-marked and sent to the frozen section. In the frozen section itself, all margins were assessed as free. However, in the basal wound area, the resection was described as just in the healthy area. A 1.5 x 3 x 4 cm slice was resected here later. This was ultimately declared tumor-free in a further frozen section. A total of 2/3 of the anterior part of the tongue was preserved. The tip of the tongue itself is completely preserved. A 1/3 resection was performed in the posterior area. The lingual nerve and Wharton's duct were completely preserved. Repositioning, injection and covering for neck dissection on both sides. Start of the modified, radical neck dissection on the left side by . Skin incision. Separation of the platysma and formation of a small platysmal flap in the ventral area. Exposure of the sternocleidomastoid muscle. Locate the omohyoid muscle and expose it. Then turn to the cranial region and locate the submandibular gland, which is also well visualized. Locate the internal jugular vein. Now completely release the sternocleidomastoid muscle while sparing the external jugular vein. Release of the upper neck block. This shows some enlarged lymph nodes, which were all removed. Exposure of the facial vein, which could be completely preserved. Finding the superior thyroid artery. This was also completely preserved, but is very thin and slender. Now turn to the internal jugular vein. This is triggered by fat and connective tissue. Release of the superficial fatty tissue cranial to the omohyoid muscle. Further evacuation of the fatty tissue lying above the plexus. Exposure of the accessorius nerve. Release of level IIb above the accessory nerve. Irrigation and bipolar coagulation to stop bleeding. Turn to the opposite side and perform the modified radical neck dissection by . Skin incision and similar procedure as on the left side. First separation of the platysma and formation of a small platysmal flap in the ventral area. Exposure of the sternocleidomastoid muscle and release of this muscle. Finding the external jugular vein. This can remain completely intact. Locate the lower border by exposing the omohyoid muscle. Then locate the upper border by exposing the submandibular gland. Then start releasing the upper neck block, beginning at the omohyoid muscle. Release of the fatty tissue in this area. No lymph nodes are visible. At the level of the superior thyroid artery, no further dissection is carried out downwards. The superior thyroid artery itself is also a very slender vessel on this side. However, it can be completely preserved. Exposure and release of the internal jugular vein. The facial vein is exposed and completely preserved. Removal of fatty tissue which lies above the plexus. Exposure of the accessorius nerve and release of the upper accessorius triangle. Wound irrigation with H202 and Ringer. Bipolar coagulation to stop bleeding. Insertion of Redon drains on both sides. During the neck dissection on both sides, all relevant vessels for a possible subsequent flap plasty were preserved (external jugular vein, facial vein, internal jugular vein, superior thyroid artery). The patient is now repositioned and the resection in the basal wound bed described above is performed. Then turn to the tracheotomy. Skin incision just below the cricoid cartilage. Now dissect in depth. Push the infrahyoid muscles to the side. A very small thyroid gland is now encountered. This can be pushed completely to the side and does not have to be severed. Removal of connective tissue on the trachea. Insertion between the 2nd and 3rd cricoid cartilage into the trachea. Unfortunately, this breaks the cuff. Formation of a basally pedicled Björk flap downwards. Incision of the Björk flap and the upper and lateral tracheal margin in the usual manner. Re-intubation. Now check the mouth and tongue area again. Remaining hemostasis here. End of the operation with dry blood. Conclusion: According to the frozen section, the tumor was resected in sano at all edges. The tip of the tongue, the lingual nerve, Wharton's and Wharton's canal were preserved. The lingual artery was carefully ligated. During the neck dissection, all vessels necessary for a possible flap plasty were preserved. If a flap plasty is required secondarily to improve function, a radial flap is recommended. After receiving the final histology, the patient must be presented at the tumor conference for possible planning of adjuvant therapy. \ No newline at end of file diff --git a/366/InvasionFront_CD3_block12_x1_y10_patient366_0.json b/366/InvasionFront_CD3_block12_x1_y10_patient366_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eace1cefa06a913179932fad5046383c7fd32ac5 --- /dev/null +++ b/366/InvasionFront_CD3_block12_x1_y10_patient366_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3298.3, + "Centroid Y µm": 29084.6, + "Num Detections": 18861, + "Num Negative": 17615, + "Num Positive": 1246, + "Positive %": 6.606, + "Num Positive per mm^2": 549.67 + } +} \ No newline at end of file diff --git a/366/InvasionFront_CD3_block12_x2_y10_patient366_1.json b/366/InvasionFront_CD3_block12_x2_y10_patient366_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7ee81d1d8ba3ef13eece71baf9270fe9dcb044e7 --- /dev/null +++ b/366/InvasionFront_CD3_block12_x2_y10_patient366_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5921.9, + "Centroid Y µm": 29234.5, + "Num Detections": 17400, + "Num Negative": 16214, + "Num Positive": 1186, + "Positive %": 6.816, + "Num Positive per mm^2": 536.76 + } +} \ No newline at end of file diff --git a/366/InvasionFront_CD8_block12_x1_y10_patient366_0.json b/366/InvasionFront_CD8_block12_x1_y10_patient366_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9a76eacd9de5080775980a1ad6437d5876f42f15 --- /dev/null +++ b/366/InvasionFront_CD8_block12_x1_y10_patient366_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5172.3, + "Centroid Y µm": 29209.5, + "Num Detections": 18238, + "Num Negative": 17642, + "Num Positive": 596, + "Positive %": 3.268, + "Num Positive per mm^2": 266.85 + } +} \ No newline at end of file diff --git a/366/InvasionFront_CD8_block12_x2_y10_patient366_1.json b/366/InvasionFront_CD8_block12_x2_y10_patient366_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f560aca1b595c6af07d39cf52c2c7a04990aeb8 --- /dev/null +++ b/366/InvasionFront_CD8_block12_x2_y10_patient366_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7895.8, + "Centroid Y µm": 29084.6, + "Num Detections": 17887, + "Num Negative": 17476, + "Num Positive": 411, + "Positive %": 2.298, + "Num Positive per mm^2": 186.33 + } +} \ No newline at end of file diff --git a/366/TumorCenter_CD3_block12_x1_y10_patient366_0.json b/366/TumorCenter_CD3_block12_x1_y10_patient366_0.json new file mode 100644 index 0000000000000000000000000000000000000000..47a47237f1005b669c481e33f4083b5b0eb0cadc --- /dev/null +++ b/366/TumorCenter_CD3_block12_x1_y10_patient366_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3348.2, + "Centroid Y µm": 24637.0, + "Num Detections": 19832, + "Num Negative": 17657, + "Num Positive": 2175, + "Positive %": 10.97, + "Num Positive per mm^2": 998.42 + } +} \ No newline at end of file diff --git a/366/TumorCenter_CD3_block12_x2_y10_patient366_1.json b/366/TumorCenter_CD3_block12_x2_y10_patient366_1.json new file mode 100644 index 0000000000000000000000000000000000000000..409eaa902c5c260ab1c1ef4446add7bfd0efcab6 --- /dev/null +++ b/366/TumorCenter_CD3_block12_x2_y10_patient366_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5821.9, + "Centroid Y µm": 24686.9, + "Num Detections": 19915, + "Num Negative": 17640, + "Num Positive": 2275, + "Positive %": 11.42, + "Num Positive per mm^2": 1028.6 + } +} \ No newline at end of file diff --git a/366/TumorCenter_CD8_block12_x1_y10_patient366_0.json b/366/TumorCenter_CD8_block12_x1_y10_patient366_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c70fa0d668b687fab1ab1e5430c77e880dc204f3 --- /dev/null +++ b/366/TumorCenter_CD8_block12_x1_y10_patient366_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6246.7, + "Centroid Y µm": 33557.2, + "Num Detections": 18473, + "Num Negative": 17725, + "Num Positive": 748, + "Positive %": 4.049, + "Num Positive per mm^2": 353.58 + } +} \ No newline at end of file diff --git a/366/TumorCenter_CD8_block12_x2_y10_patient366_1.json b/366/TumorCenter_CD8_block12_x2_y10_patient366_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b677255a1909e05ca9c79a52759b1bb198b0d66 --- /dev/null +++ b/366/TumorCenter_CD8_block12_x2_y10_patient366_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8770.4, + "Centroid Y µm": 33732.1, + "Num Detections": 17490, + "Num Negative": 16867, + "Num Positive": 623, + "Positive %": 3.562, + "Num Positive per mm^2": 287.83 + } +} \ No newline at end of file diff --git a/366/history_text.txt b/366/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/366/icd_codes.txt b/366/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/366/ops_codes.txt b/366/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/366/patient_clinical_data.json b/366/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..81c80c2878c4ea7e843caaaab58de0d1c7b31139 --- /dev/null +++ b/366/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/366/patient_pathological_data.json b/366/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4a4c67dd8b16df63701bed0b78aaae07e856313c --- /dev/null +++ b/366/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "366", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/366/surgery_description.txt b/366/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9c10ec277c4e01cbbf29b7691adf1199d1832dad --- /dev/null +++ b/366/surgery_description.txt @@ -0,0 +1 @@ +Partial tongue resection, Bilateral neck dissection, Radial flap, PEG placement diff --git a/366/surgery_report.txt b/366/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/367/InvasionFront_CD3_block2_x5_y10_patient367_0.json b/367/InvasionFront_CD3_block2_x5_y10_patient367_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4ce7adf1215bc5903b5a8ea48724db8ab020bbd8 --- /dev/null +++ b/367/InvasionFront_CD3_block2_x5_y10_patient367_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 38579.6, + "Num Detections": 24970, + "Num Negative": 23859, + "Num Positive": 1111, + "Positive %": 4.449, + "Num Positive per mm^2": 414.28 + } +} \ No newline at end of file diff --git a/367/InvasionFront_CD3_block2_x6_y10_patient367_1.json b/367/InvasionFront_CD3_block2_x6_y10_patient367_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7482a232324e99d9f456db89f0ba2e492b07fa99 --- /dev/null +++ b/367/InvasionFront_CD3_block2_x6_y10_patient367_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21063.8, + "Centroid Y µm": 38654.5, + "Num Detections": 26661, + "Num Negative": 25080, + "Num Positive": 1581, + "Positive %": 5.93, + "Num Positive per mm^2": 575.75 + } +} \ No newline at end of file diff --git a/367/InvasionFront_CD8_block2_x5_y10_patient367_0.json b/367/InvasionFront_CD8_block2_x5_y10_patient367_0.json new file mode 100644 index 0000000000000000000000000000000000000000..302751e62a008bd7e300f16009d986eba6eea4f7 --- /dev/null +++ b/367/InvasionFront_CD8_block2_x5_y10_patient367_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17165.9, + "Centroid Y µm": 26261.1, + "Num Detections": 24634, + "Num Negative": 22476, + "Num Positive": 2158, + "Positive %": 8.76, + "Num Positive per mm^2": 821.72 + } +} \ No newline at end of file diff --git a/367/InvasionFront_CD8_block2_x6_y10_patient367_1.json b/367/InvasionFront_CD8_block2_x6_y10_patient367_1.json new file mode 100644 index 0000000000000000000000000000000000000000..acb39da2bb8576beaed3b2a524e45f6f7d2ff75f --- /dev/null +++ b/367/InvasionFront_CD8_block2_x6_y10_patient367_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19789.5, + "Centroid Y µm": 26361.0, + "Num Detections": 26013, + "Num Negative": 24154, + "Num Positive": 1859, + "Positive %": 7.146, + "Num Positive per mm^2": 693.36 + } +} \ No newline at end of file diff --git a/367/TumorCenter_CD3_block2_x5_y10_patient367_0.json b/367/TumorCenter_CD3_block2_x5_y10_patient367_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d6a07b581c6ef76ec7db901fa2f18a55fbe76ad7 --- /dev/null +++ b/367/TumorCenter_CD3_block2_x5_y10_patient367_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 24786.9, + "Num Detections": 25059, + "Num Negative": 23577, + "Num Positive": 1482, + "Positive %": 5.914, + "Num Positive per mm^2": 566.56 + } +} \ No newline at end of file diff --git a/367/TumorCenter_CD3_block2_x6_y10_patient367_1.json b/367/TumorCenter_CD3_block2_x6_y10_patient367_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6b409d4125ebb01f3c0d956cd49b3e560995d465 --- /dev/null +++ b/367/TumorCenter_CD3_block2_x6_y10_patient367_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 24936.8, + "Num Detections": 24789, + "Num Negative": 22885, + "Num Positive": 1904, + "Positive %": 7.681, + "Num Positive per mm^2": 712.51 + } +} \ No newline at end of file diff --git a/367/TumorCenter_CD8_block2_x5_y10_patient367_0.json b/367/TumorCenter_CD8_block2_x5_y10_patient367_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e285e7fd443807aa0f8ea28e514f688588660e0b --- /dev/null +++ b/367/TumorCenter_CD8_block2_x5_y10_patient367_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18215.4, + "Centroid Y µm": 24537.0, + "Num Detections": 23071, + "Num Negative": 21842, + "Num Positive": 1229, + "Positive %": 5.327, + "Num Positive per mm^2": 500.46 + } +} \ No newline at end of file diff --git a/367/TumorCenter_CD8_block2_x6_y10_patient367_1.json b/367/TumorCenter_CD8_block2_x6_y10_patient367_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d756a8831ecad6fe8737527473c8e1d880a90b9c --- /dev/null +++ b/367/TumorCenter_CD8_block2_x6_y10_patient367_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20764.0, + "Centroid Y µm": 24487.0, + "Num Detections": 23064, + "Num Negative": 21029, + "Num Positive": 2035, + "Positive %": 8.823, + "Num Positive per mm^2": 787.56 + } +} \ No newline at end of file diff --git a/367/history_text.txt b/367/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3eeae416c5fc1053cd24f1c3d846ca4ac957f3c2 --- /dev/null +++ b/367/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Histologically confirmed tonsillar carcinoma on the right. Indication for tumor tonsillectomy with neck dissection on the right if necessary. \ No newline at end of file diff --git a/367/icd_codes.txt b/367/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..22d10572fc7d8a5e7a15c33b5b31b6bfc7923dde --- /dev/null +++ b/367/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/367/ops_codes.txt b/367/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..252bfee01827ab1097ae08889efe710fbe15b7e1 --- /dev/null +++ b/367/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Schleimhaut[5-296.21 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/367/patient_clinical_data.json b/367/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..36d76d353af5e1e7aea1fcb1d64a4943d7a2d0f7 --- /dev/null +++ b/367/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 7, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/367/patient_pathological_data.json b/367/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..12f944a10d4ec1e48246744f2721b7ddfd17b2aa --- /dev/null +++ b/367/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "367", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 21.0 +} \ No newline at end of file diff --git a/367/surgery_description.txt b/367/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..79f231b4543ede674a122b6e28934947f33c2477 --- /dev/null +++ b/367/surgery_description.txt @@ -0,0 +1 @@ +Tumor-tonsillectomy, Tracheotomy diff --git a/367/surgery_report.txt b/367/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a976f617175988d80c1e9041c8756550d68800e9 --- /dev/null +++ b/367/surgery_report.txt @@ -0,0 +1 @@ +Preliminary consultation with the anesthetist. Then setting up with the tonsil retractor. There is a mass in the area of the right tonsil which does not reach the base of the tongue, extends laterally to just before the lower jaw and obviously does not exceed the upper tonsil pole of the tonsil cranially. Cut around this tumorous mass in the area of the right tonsil. Careful dissection of the tumor, which can be assessed intraoperatively in healthy tissue. The anterior and posterior palatal arch is completely resected and the pharyngeal musculature is partially resected. Careful dissection along the tumor and removal of the tumor in the area of the base of the tongue. Considering the size of the tumor, dissection conditions are considerably more difficult. Careful hemostasis. Sending the specimen for frozen section examination. A resection in healthy tissue is determined. Nevertheless, representative marginal samples are taken at all levels. As far as can be assessed intraoperatively, the tumor is completely removed. The resection extends to the base of the uvula on the right side and also includes the posterior palatal arch, so that the possibility of the patient regurgitating during spontaneous healing cannot be ruled out with certainty. For this reason, no further measures at this time. First wait for the clinical course. Should regurgitation occur, a radial flap would be indicated, so that exploration of the right neck is not carried out at the present time. Initially reconstruction of the posterior palatal arch with parts of the uvula. Suturing of the uvula with its base to the right, resulting in closure of the nasopharynx in the functional sense. Due to the large wound bed, tracheotomy is now indicated. Local anesthesia is placed below the larynx. Abjode and cover the surgical site. Incision. Exposure of the subcutaneous tissue. Exposure of the linea alba, the infrahyoid musculature. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus after appropriate ligation. Exposure of the anterior wall of the trachea. Entering the trachea between the 2nd and 3rd tracheal ring and creating a small tracheostoma. Epithelialization of the tracheostoma and reintubation of the patient. Final inspection of the wound conditions in the mouth area. Dry conditions here. Insertion of a feeding tube. Final consultation with the anesthetist. \ No newline at end of file diff --git a/368/InvasionFront_CD3_block14_x5_y6_patient368_0.json b/368/InvasionFront_CD3_block14_x5_y6_patient368_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f1ac29c11fb195b4f1e27dd0671989fd152cb7ac --- /dev/null +++ b/368/InvasionFront_CD3_block14_x5_y6_patient368_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 18940.0, + "Num Detections": 17413, + "Num Negative": 15587, + "Num Positive": 1826, + "Positive %": 10.49, + "Num Positive per mm^2": 745.45 + } +} \ No newline at end of file diff --git a/368/InvasionFront_CD3_block14_x6_y6_patient368_1.json b/368/InvasionFront_CD3_block14_x6_y6_patient368_1.json new file mode 100644 index 0000000000000000000000000000000000000000..944fa83157a229b6c807979745295fa00792b402 --- /dev/null +++ b/368/InvasionFront_CD3_block14_x6_y6_patient368_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19639.6, + "Centroid Y µm": 18989.9, + "Num Detections": 18635, + "Num Negative": 16071, + "Num Positive": 2564, + "Positive %": 13.76, + "Num Positive per mm^2": 1027.8 + } +} \ No newline at end of file diff --git a/368/InvasionFront_CD8_block14_x5_y6_patient368_0.json b/368/InvasionFront_CD8_block14_x5_y6_patient368_0.json new file mode 100644 index 0000000000000000000000000000000000000000..64d940643d5b7173e08d9f37b43f7bf5aab5e321 --- /dev/null +++ b/368/InvasionFront_CD8_block14_x5_y6_patient368_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16941.0, + "Centroid Y µm": 14667.2, + "Num Detections": 18546, + "Num Negative": 16372, + "Num Positive": 2174, + "Positive %": 11.72, + "Num Positive per mm^2": 878.15 + } +} \ No newline at end of file diff --git a/368/InvasionFront_CD8_block14_x6_y6_patient368_1.json b/368/InvasionFront_CD8_block14_x6_y6_patient368_1.json new file mode 100644 index 0000000000000000000000000000000000000000..54f30f6024a7cb17ea181b52d56e3c44182a985d --- /dev/null +++ b/368/InvasionFront_CD8_block14_x6_y6_patient368_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19489.7, + "Centroid Y µm": 14667.2, + "Num Detections": 18544, + "Num Negative": 15081, + "Num Positive": 3463, + "Positive %": 18.67, + "Num Positive per mm^2": 1399.9 + } +} \ No newline at end of file diff --git a/368/TumorCenter_CD3_block14_x5_y6_patient368_0.json b/368/TumorCenter_CD3_block14_x5_y6_patient368_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7599749b2944811150dd7537cfcc8ed5b1515056 --- /dev/null +++ b/368/TumorCenter_CD3_block14_x5_y6_patient368_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 15591.7, + "Num Detections": 10619, + "Num Negative": 10099, + "Num Positive": 520, + "Positive %": 4.897, + "Num Positive per mm^2": 282.14 + } +} \ No newline at end of file diff --git a/368/TumorCenter_CD3_block14_x6_y6_patient368_1.json b/368/TumorCenter_CD3_block14_x6_y6_patient368_1.json new file mode 100644 index 0000000000000000000000000000000000000000..df94900cb3a08f44632e16f55a3ec70133fe8913 --- /dev/null +++ b/368/TumorCenter_CD3_block14_x6_y6_patient368_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 15816.6, + "Num Detections": 18158, + "Num Negative": 14188, + "Num Positive": 3970, + "Positive %": 21.86, + "Num Positive per mm^2": 1736.6 + } +} \ No newline at end of file diff --git a/368/TumorCenter_CD8_block14_x5_y6_patient368_0.json b/368/TumorCenter_CD8_block14_x5_y6_patient368_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b6fa6e8be73a3950d5ebe3e53a3ef9658ccc7f1a --- /dev/null +++ b/368/TumorCenter_CD8_block14_x5_y6_patient368_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 15616.7, + "Num Detections": 13956, + "Num Negative": 13291, + "Num Positive": 665, + "Positive %": 4.765, + "Num Positive per mm^2": 360.77 + } +} \ No newline at end of file diff --git a/368/TumorCenter_CD8_block14_x6_y6_patient368_1.json b/368/TumorCenter_CD8_block14_x6_y6_patient368_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bfecace741085be269fbede0d01af67b0dbaee2d --- /dev/null +++ b/368/TumorCenter_CD8_block14_x6_y6_patient368_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18240.3, + "Centroid Y µm": 15666.7, + "Num Detections": 18006, + "Num Negative": 15202, + "Num Positive": 2804, + "Positive %": 15.57, + "Num Positive per mm^2": 1233.6 + } +} \ No newline at end of file diff --git a/368/history_text.txt b/368/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0db9aaebbf5cee02cf05517f0aaf936de5226e32 --- /dev/null +++ b/368/history_text.txt @@ -0,0 +1 @@ +The patient has a malignant neoplasm on the edge of the tongue on the left side, which extends to the floor of the mouth, which is why the above-mentioned surgical indication was given. With cN2c sonographic neck status, neck dissection is indicated on both sides with level I a on both sides. \ No newline at end of file diff --git a/368/icd_codes.txt b/368/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d90fc37140299b299f51a1ba8ecbf62562b905f0 --- /dev/null +++ b/368/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 L] \ No newline at end of file diff --git a/368/ops_codes.txt b/368/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0109ff32fcf2862bafdec5f7cb7cac3de30212c3 --- /dev/null +++ b/368/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/368/patient_clinical_data.json b/368/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0b69f451d89e7feb81c67f6c14ebaf0646990b7c --- /dev/null +++ b/368/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 63, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 36, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/368/patient_pathological_data.json b/368/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..060277cca2d065efdf425dd36d04ab774dcd8673 --- /dev/null +++ b/368/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "368", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.5 +} \ No newline at end of file diff --git a/368/surgery_description.txt b/368/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7b187660f32c9ad5cd4622e8001d7b94f5aa8889 --- /dev/null +++ b/368/surgery_description.txt @@ -0,0 +1 @@ +Tumor excision: Partial glossectomy diff --git a/368/surgery_report.txt b/368/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..dc010af9f3a6b0b211fbf5d65543b285b3664c8f --- /dev/null +++ b/368/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Positioning of the patient. Insertion of the mouth guard. Suturing of the tongue. Start the resection from the tumor border facing the tip of the tongue with a safety margin of about 2 - 3 mm. The tumor appears to be very extensive and not too deep. Due to the extensive growth, however, a very large resection area is visible. The resection is performed on all sides about 2 - 3 mm into the healthy tissue. The resection is performed with successive hemostasis. The tumor can ultimately be resected and removed in a circular fashion. A very extensive wound surface is revealed, which is why reconstruction may now be necessary depending on the functional outcome. As a result, the decision was made not to perform a single-stage neck dissection on both sides in order to keep the option of reconstruction open. For this reason, repeated hemostasis. Injection of local anesthetic into the wound area for postoperative pain reduction. Final consultation with the anesthetist. Completion of the procedure after removal of all instruments. Planning of neck dissection on both sides with level I a on both sides at intervals. \ No newline at end of file diff --git a/369/InvasionFront_CD3_block15_x3_y6_patient369_0.json b/369/InvasionFront_CD3_block15_x3_y6_patient369_0.json new file mode 100644 index 0000000000000000000000000000000000000000..28de8a4ee3ad003fe38e4cdfe0a285e611878d36 --- /dev/null +++ b/369/InvasionFront_CD3_block15_x3_y6_patient369_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13293.0, + "Centroid Y µm": 24961.8, + "Num Detections": 17935, + "Num Negative": 17553, + "Num Positive": 382, + "Positive %": 2.13, + "Num Positive per mm^2": 170.98 + } +} \ No newline at end of file diff --git a/369/InvasionFront_CD3_block15_x4_y6_patient369_1.json b/369/InvasionFront_CD3_block15_x4_y6_patient369_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c4b37a80fbed92d5b27db2b095b2c9f0004e15ad --- /dev/null +++ b/369/InvasionFront_CD3_block15_x4_y6_patient369_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 24811.9, + "Num Detections": 15614, + "Num Negative": 15125, + "Num Positive": 489, + "Positive %": 3.132, + "Num Positive per mm^2": 234.37 + } +} \ No newline at end of file diff --git a/369/InvasionFront_CD8_block15_x3_y6_patient369_0.json b/369/InvasionFront_CD8_block15_x3_y6_patient369_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ffb4ace6350d08af43ec05bec869e71ea29b46bc --- /dev/null +++ b/369/InvasionFront_CD8_block15_x3_y6_patient369_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11292.5, + "Centroid Y µm": 14615.8, + "Num Detections": 15251, + "Num Negative": 15216, + "Num Positive": 35, + "Positive %": 0.2295, + "Num Positive per mm^2": 16.91 + } +} \ No newline at end of file diff --git a/369/InvasionFront_CD8_block15_x4_y6_patient369_1.json b/369/InvasionFront_CD8_block15_x4_y6_patient369_1.json new file mode 100644 index 0000000000000000000000000000000000000000..643f581c773d573e51c6d348b8ceb113896d03de --- /dev/null +++ b/369/InvasionFront_CD8_block15_x4_y6_patient369_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13916.9, + "Centroid Y µm": 14594.0, + "Num Detections": 12888, + "Num Negative": 12753, + "Num Positive": 135, + "Positive %": 1.047, + "Num Positive per mm^2": 74.69 + } +} \ No newline at end of file diff --git a/369/TumorCenter_CD3_block15_x3_y6_patient369_0.json b/369/TumorCenter_CD3_block15_x3_y6_patient369_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b8256163566e66477ea08ac945c2a2d822c2ea39 --- /dev/null +++ b/369/TumorCenter_CD3_block15_x3_y6_patient369_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11319.0, + "Centroid Y µm": 18290.3, + "Num Detections": 13657, + "Num Negative": 13560, + "Num Positive": 97, + "Positive %": 0.7103, + "Num Positive per mm^2": 45.46 + } +} \ No newline at end of file diff --git a/369/TumorCenter_CD3_block15_x4_y6_patient369_1.json b/369/TumorCenter_CD3_block15_x4_y6_patient369_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c01ababf2fce60533486907656631f1c39ec3c0 --- /dev/null +++ b/369/TumorCenter_CD3_block15_x4_y6_patient369_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 18365.3, + "Num Detections": 16192, + "Num Negative": 15868, + "Num Positive": 324, + "Positive %": 2.001, + "Num Positive per mm^2": 150.73 + } +} \ No newline at end of file diff --git a/369/TumorCenter_CD8_block15_x3_y6_patient369_0.json b/369/TumorCenter_CD8_block15_x3_y6_patient369_0.json new file mode 100644 index 0000000000000000000000000000000000000000..57c9c4b9fef75164a64f0b226b12dc1263d9f52d --- /dev/null +++ b/369/TumorCenter_CD8_block15_x3_y6_patient369_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 14917.1, + "Num Detections": 15518, + "Num Negative": 15478, + "Num Positive": 40, + "Positive %": 0.2578, + "Num Positive per mm^2": 19.14 + } +} \ No newline at end of file diff --git a/369/TumorCenter_CD8_block15_x4_y6_patient369_1.json b/369/TumorCenter_CD8_block15_x4_y6_patient369_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3ccb0d5845f2808cca1c94694fa0afbe9b9eae6 --- /dev/null +++ b/369/TumorCenter_CD8_block15_x4_y6_patient369_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 14942.1, + "Num Detections": 16122, + "Num Negative": 16095, + "Num Positive": 27, + "Positive %": 0.1675, + "Num Positive per mm^2": 12.88 + } +} \ No newline at end of file diff --git a/369/history_text.txt b/369/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ebe5e78a00e7abb18157959ecd4c8ee85ece31c9 --- /dev/null +++ b/369/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed moderately differentiated squamous cell carcinoma of the right tongue margin, clinical tumor extension cT2 cN1 to cN2b on the right. \ No newline at end of file diff --git a/369/icd_codes.txt b/369/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8c238eef8a0dfb488e24bb4f5e0dc02d520588a1 --- /dev/null +++ b/369/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zunge, mehrere Teilbereiche überlappend[C02.8 ] Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/369/ops_codes.txt b/369/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b05a9ab912304c2ce2fe01fa4aee47e3b577bf5f --- /dev/null +++ b/369/ops_codes.txt @@ -0,0 +1 @@ +Exzision und Destruktion von erkranktem Gewebe des Pharynx: Resektion, partiell: Transoral[5-292.10 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Destruktion: Sonstige[5-250.3x ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 R] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 4 Regionen[5-403.20 L] \ No newline at end of file diff --git a/369/patient_clinical_data.json b/369/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f7f1fcc86f9e1b1466b310421cfa2b7422bf8f0d --- /dev/null +++ b/369/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/369/patient_pathological_data.json b/369/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d56f278caca3f81e7b4aec77eaa5ed5c554c5915 --- /dev/null +++ b/369/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "369", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/369/surgery_description.txt b/369/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..87243d2272eb5ef44dd99dc141f3d73ba1ead79b --- /dev/null +++ b/369/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Modified radical neck dissection diff --git a/369/surgery_report.txt b/369/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..de16a09dba32325d62d366d9a0b8631f7f7c962b --- /dev/null +++ b/369/surgery_report.txt @@ -0,0 +1 @@ +During induction of anesthesia, first head positioning and nasotracheal intubation by the anesthesia colleagues. Subsequent inspection of the oral cavity after suturing the tip of the tongue. The previously described exophytic process of the posterior edge of the tongue on the right with transition to the right tongue base, the glossotonsillar groove or the lower tonsillar pole on the right is seen. Demonstration of the findings on and determination of the resection margins. On palpation, the tumor extends into the base of the tongue with a cone, but is superficial towards the tip of the tongue or the anterior edge of the tongue. Now dissect the tumor with sufficient safety distance using bipolar coagulation and scissors from anterior to posterior. The tumor cone described above can be seen in the base of the tongue, resulting in a deeper resection in the sense of a one-third resection of the base of the tongue. In addition, the suspicious mucosal area towards the oropharyngeal side wall or tonsil is resected in the sense of a tumor tonsillectomy after further consultation with with a sufficient macroscopic safety margin. Hemostasis with bipolar coagulation and H202. Subsequent removal of circular margin samples, anterior tongue margin, lower tongue margin, upper tongue margin, tongue base and pharyngeal wall. These are all found to be tumor-free in the frozen section. It can therefore be assumed that the resection was R0 on the basis of markoscopy and microscopy. Now demonstration of the findings and discussion with and . Indication for level I to V neck dissection on the right and level II to V on the left. Start with neck dissection on the right: repositioning of the patient, infiltration anesthesia and skin incision on the anterior edge of the sternocleidomastoid muscle with an auxiliary submental incision. Dissection through subcutaneous tissue and platysma, on the sternocleidomastoid muscle in depth. Exposure of the omohyoid muscle, the digastric muscle, the prelaryngeal musculature, the internal jugular vein in its course, the facial vein, the common carotid artery with division into external and internal. The accessorius nerve, the hypoglossal nerve, the deep cervical artery and the branches of the cervicobrachial plexus, these structures are all spared and the lateral neck preparation is now cleared out caudally starting at the accessorius triangle. Several enlarged nodes can be seen. There is also a nodule in the medial neck preparation, here appearing suspiciously in the vein angle. Clearing of the medial neck preparation and further preparation with removal of the capsule of the submandibular gland anteriorly and submentally, here clearing of the fatty tissue, but no suspicious findings on palpation. Overall clinical findings of cN1 status on the right. Then turn to the left side. Here too, skin incision on the anterior edge of the sternocleidomastoid muscle. After infiltration anesthesia, dissection in depth, exposing the structures mentioned on the right side. Here too, protection of the same and dissection of the median and lateral neck preparation. Finally, hemostasis using bipolar coagulation. H202 and ring irrigation as well as repeated demonstration of findings on if the surgical site is free of bleeding. Insertion of a Redon drain and two-layer wound closure and wound dressing. Finally, re-inspection of the oral cavity, here no further bleeding and adaptation sutures in the area of the right edge of the tongue up to the base of the tongue. Completion of the procedure without bleeding or complications. Transfer of the patient to the intensive care unit, where the file is also taken. \ No newline at end of file diff --git a/370/InvasionFront_CD3_block21_x5_y4_patient370_0.json b/370/InvasionFront_CD3_block21_x5_y4_patient370_0.json new file mode 100644 index 0000000000000000000000000000000000000000..10d9de96f7584cffbfb0b14f896d7df032861fd5 --- /dev/null +++ b/370/InvasionFront_CD3_block21_x5_y4_patient370_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 20789.0, + "Num Detections": 24338, + "Num Negative": 22024, + "Num Positive": 2314, + "Positive %": 9.508, + "Num Positive per mm^2": 861.92 + } +} \ No newline at end of file diff --git a/370/InvasionFront_CD3_block21_x6_y4_patient370_1.json b/370/InvasionFront_CD3_block21_x6_y4_patient370_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d95a9bde01b6699afa0d7f219a4f640fca07d6a2 --- /dev/null +++ b/370/InvasionFront_CD3_block21_x6_y4_patient370_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21688.5, + "Centroid Y µm": 20963.9, + "Num Detections": 23971, + "Num Negative": 22777, + "Num Positive": 1194, + "Positive %": 4.981, + "Num Positive per mm^2": 441.82 + } +} \ No newline at end of file diff --git a/370/InvasionFront_CD8_block21_x5_y4_patient370_0.json b/370/InvasionFront_CD8_block21_x5_y4_patient370_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d157db3d231f5127f24ace0c92fcb627cb3a42b0 --- /dev/null +++ b/370/InvasionFront_CD8_block21_x5_y4_patient370_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 9869.8, + "Num Detections": 25060, + "Num Negative": 21565, + "Num Positive": 3495, + "Positive %": 13.95, + "Num Positive per mm^2": 1287.1 + } +} \ No newline at end of file diff --git a/370/InvasionFront_CD8_block21_x6_y4_patient370_1.json b/370/InvasionFront_CD8_block21_x6_y4_patient370_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd99f11f24b885fcbd6ce7363b4eb6ee7efa9079 --- /dev/null +++ b/370/InvasionFront_CD8_block21_x6_y4_patient370_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 9869.8, + "Num Detections": 23052, + "Num Negative": 22833, + "Num Positive": 219, + "Positive %": 0.95, + "Num Positive per mm^2": 80.5 + } +} \ No newline at end of file diff --git a/370/TumorCenter_CD3_block21_x5_y4_patient370_0.json b/370/TumorCenter_CD3_block21_x5_y4_patient370_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7cb32fd87c8283ecd44d76caf5d6f5fcbd5a313d --- /dev/null +++ b/370/TumorCenter_CD3_block21_x5_y4_patient370_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 12543.4, + "Num Detections": 20448, + "Num Negative": 20114, + "Num Positive": 334, + "Positive %": 1.633, + "Num Positive per mm^2": 141.14 + } +} \ No newline at end of file diff --git a/370/TumorCenter_CD3_block21_x6_y4_patient370_1.json b/370/TumorCenter_CD3_block21_x6_y4_patient370_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b513bff87b3b4813ee88ef8cc450bd975dd8d1b5 --- /dev/null +++ b/370/TumorCenter_CD3_block21_x6_y4_patient370_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 12443.4, + "Num Detections": 22231, + "Num Negative": 21701, + "Num Positive": 530, + "Positive %": 2.384, + "Num Positive per mm^2": 205.6 + } +} \ No newline at end of file diff --git a/370/TumorCenter_CD8_block21_x5_y4_patient370_0.json b/370/TumorCenter_CD8_block21_x5_y4_patient370_0.json new file mode 100644 index 0000000000000000000000000000000000000000..481e8490ca9b11d3bd1eb3febcfe543fed9b4e14 --- /dev/null +++ b/370/TumorCenter_CD8_block21_x5_y4_patient370_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 25061.7, + "Num Detections": 21111, + "Num Negative": 21015, + "Num Positive": 96, + "Positive %": 0.4547, + "Num Positive per mm^2": 41.72 + } +} \ No newline at end of file diff --git a/370/TumorCenter_CD8_block21_x6_y4_patient370_1.json b/370/TumorCenter_CD8_block21_x6_y4_patient370_1.json new file mode 100644 index 0000000000000000000000000000000000000000..941778659480d8d13a8a8661aed881f1578a45d4 --- /dev/null +++ b/370/TumorCenter_CD8_block21_x6_y4_patient370_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21463.6, + "Centroid Y µm": 25186.7, + "Num Detections": 22600, + "Num Negative": 22352, + "Num Positive": 248, + "Positive %": 1.097, + "Num Positive per mm^2": 96.0 + } +} \ No newline at end of file diff --git a/370/history_text.txt b/370/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9f2ddb9ab68324f6b6117a56b97f0654902e1409 --- /dev/null +++ b/370/history_text.txt @@ -0,0 +1 @@ +Mr. has a postoperative mandibular carcinoma, which was resected and neck dissection treated by colleagues in oral surgery in 1995, but did not receive adjuvant therapy. The patient now presents with a histologically confirmed carcinoma in situ (grade III intraepithelial neoplasia). Endoscopy revealed a very uneven mucosa, raised above the normal mucosal level, primarily affecting the left pocket fold. Therefore indication for the above mentioned operation. \ No newline at end of file diff --git a/370/icd_codes.txt b/370/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2a29c75dae9ef5bab696cdf7b590533284d42cab --- /dev/null +++ b/370/icd_codes.txt @@ -0,0 +1 @@ +KURS Bösartige Neubildung: Glottis[C32.0 ] Bösartige Neubildung der Glottis[C32.0 ] \ No newline at end of file diff --git a/370/ops_codes.txt b/370/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d84bd11250e7c627edaa7fa92bd364bb903ee3c8 --- /dev/null +++ b/370/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Exzision, mikrolaryngoskopisch[5-300.2 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Destruktion: Laserkoagulation[5-300.31 ] Andere partielle Laryngektomie: Endoskopische Laserresektion[5-302.5 ] Andere partielle Laryngektomie: Chordektomie, endolaryngeal[5-302.1 ] \ No newline at end of file diff --git a/370/patient_clinical_data.json b/370/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3de6ccfb66dbecb2956b86d0692de42d8d34bc58 --- /dev/null +++ b/370/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/370/patient_pathological_data.json b/370/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..70116449fcbb4f0204e93bffc25ff04fe6eab804 --- /dev/null +++ b/370/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "370", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/370/surgery_description.txt b/370/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..dbc88e20334af4622ab9be3d5eecec393793eb69 --- /dev/null +++ b/370/surgery_description.txt @@ -0,0 +1 @@ +Transoral laser resection, Panendoscopy diff --git a/370/surgery_report.txt b/370/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6667c0860d41f0e72daf899645f420a7fae62557 --- /dev/null +++ b/370/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia, tracheoscopy is first performed with 0 degree optics. This reveals a subglottic protrusion of a tracheal cartilage with a slight narrowing of the tracheal lumen by approx. 20 %. However, the mucosa is not irritated. Now orotracheal intubation by the surgeon. Then proceed to flexible esophagogastroscopy. Mucosal conditions are normal on all sides, even in the cardia area after inversion and in the pylorus area. No further abnormalities of the esophagus when the endoscope is withdrawn. Now proceed to panendoscopy. Apart from the tumor described below, there are no other abnormalities in the entire oropharyngeal, hypopharyngeal and laryngeal region. The tumor itself is a clearly uneven mucosal region with elevation and a slightly exophytic aspect in the area of the left pocket fold, which also affects the upper side of the left vocal fold in its central area via the morgue sinus. The anterior region and also the anterior commissure are tumor-free. The free aryepiglottic fold is not affected, but the tumor grows over into the ary region in the posterior part of the pocket fold and the vocal fold also appears relatively unsteady in the area of the vocal process. Now repeated consultation of and , which ultimately indicated the performance of laser resection with frozen section examinations. The anterior section is now set to 3 watt continuous mode with the CO2 laser and the left pocket fold is resected. The anterior part of the left vocal fold is then also resected with the laser in its upper part up to the free edge. The vocal cord can be preserved if the findings are relatively superficial, as can the vocalis muscle. Now setting the posterior side. Here the resection extends over the pocket fold to the free aryepiglottic fold and then medially over the arytenoid cartilage almost to the interary region without entering it. Here, too, the findings are clearly superficial and the arytenoid cartilage itself can be preserved. Now, although there is no clinical suspicion that the mass is extending into the depths, the wound bed is resected again in the supraglottic area corresponding to the pocket crease, because the CT suggests that the tumor is deeper in this area. In between, repeated coagulation with the forceps and monopolar coagulation. Finally, frozen section diagnostics are performed. Six frozen sections are taken from the free edge of the glottis via the arytenoid region, in the wound bed along the pocket crease, again in the anterior pocket crease and in the anterior commissure area. All frozen sections were found to be tumor-free. Only the arytenoid region is removed with slight dysplasia. For this reason, a small strip is recut in this area. In between, careful hemostasis with placement of supra-swabs. Placement of a feeding tube, which should be left in place for 7 days. Intraoperative administration of 3 g Unacid, which should be continued for 24 hours, and 250 mg SDH single-shot. Conclusion: cT2 ycN0 supraglottic laryngeal carcinoma with involvement of the morgue sinus and vocal fold on the left side. R0 resection in the frozen section. Further procedure after receipt of the final histology, whereby it should be discussed in the tumor conference whether a new neck dissection can be dispensed with in the case of ycN0 neck status and pre-treatment of the patient. \ No newline at end of file diff --git a/371/InvasionFront_CD3_block8_x5_y8_patient371_0.json b/371/InvasionFront_CD3_block8_x5_y8_patient371_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ebcbe32fa946e6ca490c5999136b4c5fda3b0293 --- /dev/null +++ b/371/InvasionFront_CD3_block8_x5_y8_patient371_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 30259.0, + "Num Detections": 21097, + "Num Negative": 20839, + "Num Positive": 258, + "Positive %": 1.223, + "Num Positive per mm^2": 107.37 + } +} \ No newline at end of file diff --git a/371/InvasionFront_CD3_block8_x6_y8_patient371_1.json b/371/InvasionFront_CD3_block8_x6_y8_patient371_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7944c213a2a065cd22789dda361fc017ac00a9e5 --- /dev/null +++ b/371/InvasionFront_CD3_block8_x6_y8_patient371_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 30284.0, + "Num Detections": 18608, + "Num Negative": 18473, + "Num Positive": 135, + "Positive %": 0.7255, + "Num Positive per mm^2": 59.08 + } +} \ No newline at end of file diff --git a/371/InvasionFront_CD8_block8_x5_y8_patient371_0.json b/371/InvasionFront_CD8_block8_x5_y8_patient371_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fd5c740683691854e48fdc828126990a803b5dde --- /dev/null +++ b/371/InvasionFront_CD8_block8_x5_y8_patient371_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 20814.0, + "Num Detections": 21539, + "Num Negative": 20427, + "Num Positive": 1112, + "Positive %": 5.163, + "Num Positive per mm^2": 459.84 + } +} \ No newline at end of file diff --git a/371/InvasionFront_CD8_block8_x6_y8_patient371_1.json b/371/InvasionFront_CD8_block8_x6_y8_patient371_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2781dd18ea2ace0b18a372660573d1b4b8291e1c --- /dev/null +++ b/371/InvasionFront_CD8_block8_x6_y8_patient371_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 21038.9, + "Num Detections": 21117, + "Num Negative": 20156, + "Num Positive": 961, + "Positive %": 4.551, + "Num Positive per mm^2": 415.27 + } +} \ No newline at end of file diff --git a/371/TumorCenter_CD3_block8_x5_y8_patient371_0.json b/371/TumorCenter_CD3_block8_x5_y8_patient371_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e0519616f47ef508e28fe40eee17f97c26c847e0 --- /dev/null +++ b/371/TumorCenter_CD3_block8_x5_y8_patient371_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17540.7, + "Centroid Y µm": 20364.2, + "Num Detections": 19465, + "Num Negative": 18874, + "Num Positive": 591, + "Positive %": 3.036, + "Num Positive per mm^2": 256.52 + } +} \ No newline at end of file diff --git a/371/TumorCenter_CD3_block8_x6_y8_patient371_1.json b/371/TumorCenter_CD3_block8_x6_y8_patient371_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a0741a94207a9f71950fbc4bc5f3c314023f1601 --- /dev/null +++ b/371/TumorCenter_CD3_block8_x6_y8_patient371_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20114.3, + "Centroid Y µm": 20064.4, + "Num Detections": 18981, + "Num Negative": 18582, + "Num Positive": 399, + "Positive %": 2.102, + "Num Positive per mm^2": 172.83 + } +} \ No newline at end of file diff --git a/371/TumorCenter_CD8_block8_x5_y8_patient371_0.json b/371/TumorCenter_CD8_block8_x5_y8_patient371_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0e950dceab8c6850e1d3c5930e785d828190146 --- /dev/null +++ b/371/TumorCenter_CD8_block8_x5_y8_patient371_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17215.9, + "Centroid Y µm": 20189.3, + "Num Detections": 20855, + "Num Negative": 20464, + "Num Positive": 391, + "Positive %": 1.875, + "Num Positive per mm^2": 172.29 + } +} \ No newline at end of file diff --git a/371/TumorCenter_CD8_block8_x6_y8_patient371_1.json b/371/TumorCenter_CD8_block8_x6_y8_patient371_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0d18ab892d8d4658d6867ccac1cca059c1028334 --- /dev/null +++ b/371/TumorCenter_CD8_block8_x6_y8_patient371_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19814.5, + "Centroid Y µm": 20039.4, + "Num Detections": 20934, + "Num Negative": 20646, + "Num Positive": 288, + "Positive %": 1.376, + "Num Positive per mm^2": 128.33 + } +} \ No newline at end of file diff --git a/371/history_text.txt b/371/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/371/icd_codes.txt b/371/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..223529347367f09bbe6195d2a9866fd8353672b5 --- /dev/null +++ b/371/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] Lymphknotenvergrößerung, umschrieben[R59.0 ] \ No newline at end of file diff --git a/371/ops_codes.txt b/371/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a487f31f6fefb0c560bc06624832355b044b42fe --- /dev/null +++ b/371/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Tonsillektomie (ohne Adenotomie): Radikal, transoral[5-281.2 ] Tonsillektomie (ohne Adenotomie): Radikal, durch Pharyngotomie[5-281.3 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 R] Pharyngoplastik: Mit gestieltem myokutanen Lappen[5-293.1 ] Pharyngotomie: Lateral[5-290.3 ] \ No newline at end of file diff --git a/371/patient_clinical_data.json b/371/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c1f5965f0f5f0788569fb36efb47c4975c49f637 --- /dev/null +++ b/371/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2008, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/371/patient_pathological_data.json b/371/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..89b29807609491fb9c8eea83cda1de4aa72c7752 --- /dev/null +++ b/371/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "371", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/371/surgery_description.txt b/371/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1441c4f63dfd459da3cc3b51f1f9d76fcdeaa991 --- /dev/null +++ b/371/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy on the right, Right neck dissection, Pharyngeal reconstruction, Pedicled flap (Platysma), PEG placement, Endoscopy diff --git a/371/surgery_report.txt b/371/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0589bc6b07dd659c55aac7419a9681067e2c0a29 --- /dev/null +++ b/371/surgery_report.txt @@ -0,0 +1 @@ +At the beginning of the operation, the surgeon positions the patient. After induction of anesthesia, a new pharyngo-laryngoscopy is performed, confirming the findings of the preliminary examination. Comparison with the CT findings. It was found that the tumor was relatively well encapsulated, a cN0 situation was present, therefore now after esophagogastroscopy with good diaphanoscopy and insertion of the troicart. After alcohol disinfection, infiltration anesthesia, placement of the PEG tube in the typical manner and subsequent insertion of the tonsil plug. The overview is poor with restricted mouth opening, especially of the caudal part, so that the combined transoral, transcervical approach is preferred. Reposition the patient for this. Alcohol disinfection. Infiltration anesthesia and preforming of a platysmal flap. To do this, first make a skin incision into the subcutaneous tissue. Cut around the suspected defect in the supraclavicular area, lift off the skin laterally and medially of the neck incision above the platysma. Expose the platysma at the level of the clavicle. Separation of the same. Here and fixation sutures skin platysma. Then carefully dissect cranially, taking the platysma and the surrounding connective tissue structures up to the capsule of the submandibular gland and preserving the facial artery and vein. Now expose the cervical vascular sheath, expose the vagus nerve and hypoglossal nerve as well as the accessorius nerve. Clearing out the lateral neck preparation from the omohyoid to the digaster, sparing the aforementioned structures and the main plexus branches. Exposure of the medial neck preparation and removal of the same, including the capsule of the submandibular gland and preservation of the other structures mentioned, including the artery and superior vein. Now dissect the ventral part of the digastric muscle and the styloid muscle. Dissection of the same. Counterpalpation of oral and cervical. The smoothly bordered tumor can be seen and that when entering the pharynx one emerges just caudal to the hypoglossus below the tumor. Therefore, re-insertion of the tonsil stop, cutting around the tumor from the cranial side, including the anterior palatal arch, parts of the soft palate and the lateral pharyngeal wall up to the alveolar ridge. Dissection clearly macroscopically in healthy tissue, including muscle layers on the tumor. Now dissect caudally as far as this is possible without complications, then open the pharynx below the tumor and cut around the caudal parts of the tumor under visual control. Development of the complete tumor specimen which is sent for final histology. Forming a resection in the area cranial to the entrance to the operation, as submucosal growth could not be ruled out by palpation. Subsequently, representative marginal samples are taken circularly. All of these, including the tongue margin sample, were found to be tumor-free by from the pathology department, so that a safe R0 resection can be assumed. After careful hemostasis and wound irrigation, the caudal pharyngeal opening is widened so that the flap stalk is not trapped; the lingual artery is cut and severed for this purpose. The flap is then swung into the defect; this is achieved without tension up to the upper palatal arch, where the flap is adapted to the mucosal borders and the posterior palatal arch. The uvula remains freely movable. Adaptation to the caudal side. Now turn towards the transverical and reduce the pharyngeal access. Then suture the accompanying connective and fatty tissue of the flap pedicle with the pharyngeal musculature to create a complete closure. Finally, insertion of a Redon drainage and two-layer wound closure by forming a Burrow triangle can achieve complete primary closure. Please apply a pressure dressing to the lower third of the neck scar, never to the cranial third. If problems occur, the lateral part of the flap can be primarily released from the suture and sutured again secondarily. \ No newline at end of file diff --git a/372/InvasionFront_CD3_block9_x1_y10_patient372_0.json b/372/InvasionFront_CD3_block9_x1_y10_patient372_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3afbaf13faec83f619d7c06a5445db895f5bc7cd --- /dev/null +++ b/372/InvasionFront_CD3_block9_x1_y10_patient372_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 25036.7, + "Num Detections": 18243, + "Num Negative": 15121, + "Num Positive": 3122, + "Positive %": 17.11, + "Num Positive per mm^2": 1440.3 + } +} \ No newline at end of file diff --git a/372/InvasionFront_CD3_block9_x2_y10_patient372_1.json b/372/InvasionFront_CD3_block9_x2_y10_patient372_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d69dacedb4aeb55e21a8eb4dcf826c4fdb63d055 --- /dev/null +++ b/372/InvasionFront_CD3_block9_x2_y10_patient372_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6646.5, + "Centroid Y µm": 25461.5, + "Num Detections": 7313, + "Num Negative": 6157, + "Num Positive": 1156, + "Positive %": 15.81, + "Num Positive per mm^2": 1277.7 + } +} \ No newline at end of file diff --git a/372/InvasionFront_CD8_block9_x1_y10_patient372_0.json b/372/InvasionFront_CD8_block9_x1_y10_patient372_0.json new file mode 100644 index 0000000000000000000000000000000000000000..98e195cfd0dc6d87cfad11402a8d36a51cf24909 --- /dev/null +++ b/372/InvasionFront_CD8_block9_x1_y10_patient372_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4297.7, + "Centroid Y µm": 28509.9, + "Num Detections": 18537, + "Num Negative": 13894, + "Num Positive": 4643, + "Positive %": 25.05, + "Num Positive per mm^2": 2160.6 + } +} \ No newline at end of file diff --git a/372/InvasionFront_CD8_block9_x2_y10_patient372_1.json b/372/InvasionFront_CD8_block9_x2_y10_patient372_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5f05243950b6456cb51a3288221920cba1602858 --- /dev/null +++ b/372/InvasionFront_CD8_block9_x2_y10_patient372_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 28984.7, + "Num Detections": 12459, + "Num Negative": 10388, + "Num Positive": 2071, + "Positive %": 16.62, + "Num Positive per mm^2": 1300.5 + } +} \ No newline at end of file diff --git a/372/TumorCenter_CD3_block9_x1_y10_patient372_0.json b/372/TumorCenter_CD3_block9_x1_y10_patient372_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9a3a8c979f055154da1f684e6174501708f34fb0 --- /dev/null +++ b/372/TumorCenter_CD3_block9_x1_y10_patient372_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.1, + "Centroid Y µm": 30458.9, + "Num Detections": 18211, + "Num Negative": 11667, + "Num Positive": 6544, + "Positive %": 35.93, + "Num Positive per mm^2": 2831.7 + } +} \ No newline at end of file diff --git a/372/TumorCenter_CD3_block9_x2_y10_patient372_1.json b/372/TumorCenter_CD3_block9_x2_y10_patient372_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b622259c02922501a91f0b933dd77db88ec02b7 --- /dev/null +++ b/372/TumorCenter_CD3_block9_x2_y10_patient372_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 30508.8, + "Num Detections": 21713, + "Num Negative": 14801, + "Num Positive": 6912, + "Positive %": 31.83, + "Num Positive per mm^2": 3005.9 + } +} \ No newline at end of file diff --git a/372/TumorCenter_CD8_block9_x1_y10_patient372_0.json b/372/TumorCenter_CD8_block9_x1_y10_patient372_0.json new file mode 100644 index 0000000000000000000000000000000000000000..291df8139578f6624b3167e7027508b7df2e37b8 --- /dev/null +++ b/372/TumorCenter_CD8_block9_x1_y10_patient372_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 26535.9, + "Num Detections": 12815, + "Num Negative": 8543, + "Num Positive": 4272, + "Positive %": 33.34, + "Num Positive per mm^2": 2530.6 + } +} \ No newline at end of file diff --git a/372/TumorCenter_CD8_block9_x2_y10_patient372_1.json b/372/TumorCenter_CD8_block9_x2_y10_patient372_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b3e1e82fa4f16c86852b1ecd15c240bf5bddf184 --- /dev/null +++ b/372/TumorCenter_CD8_block9_x2_y10_patient372_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6721.4, + "Centroid Y µm": 26560.9, + "Num Detections": 17289, + "Num Negative": 11601, + "Num Positive": 5688, + "Positive %": 32.9, + "Num Positive per mm^2": 2801.4 + } +} \ No newline at end of file diff --git a/372/history_text.txt b/372/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/372/icd_codes.txt b/372/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..620c6067dd5a75b37bd33601172c4c227f9faa13 --- /dev/null +++ b/372/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Seitenwand des Oropharynx[C10.2 R] Neubildung bösartig Halslymphknoten[C77.0 R] \ No newline at end of file diff --git a/372/ops_codes.txt b/372/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dfeaeaf04bac6d7dcbdcb575d64fa60cb6ed7e32 --- /dev/null +++ b/372/ops_codes.txt @@ -0,0 +1 @@ +Temporäre Tracheotomie[5-311.0 ] Diagnostische Ösophagogastroskopie[1-631 ] PEG-Sonde Anlage[5-431.2 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 L] Radikale Neck dissection in 4 Regionen[5-403.10 R] \ No newline at end of file diff --git a/372/patient_clinical_data.json b/372/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5ae024a6a67170fcc5d62000dd570d9bf243b4fd --- /dev/null +++ b/372/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/372/patient_pathological_data.json b/372/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b25b7f6fe4e12601ae49b90758193b04564765ec --- /dev/null +++ b/372/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "372", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/372/surgery_description.txt b/372/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..dde9134b6f0636ec228655626a238f1dcfafe06b --- /dev/null +++ b/372/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Tracheotomy, PEG placement diff --git a/372/surgery_report.txt b/372/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..319082fbeb9d48732b8bea8e8befa0f9e3c464ee --- /dev/null +++ b/372/surgery_report.txt @@ -0,0 +1 @@ +() Induction of anesthesia and intubation transnasally by the anesthesia colleagues. Placement of a PEG using the thread pull-through method by and . No complications and no abnormalities. Insertion of the tonsil plug and inspection of the oropharynx on the right side. A coarse, exophytic tumor is seen at the upper pole of the tonsil, which grows laterally and includes the upper tonsil. The posterior and anterior palatal arch are only partially infiltrated. Demonstration on and , who alternately resect this tumor. The tumor is thread-marked for frozen section. The pathologist determines an R0 situation. The lateral pharyngeal muscles on the right side are still sufficiently intact, so the decision is made to perform a neck dissection on both sides. Initially start on the left side. Skin incision on the anterior edge of the sternocleidomastoid muscle. Creation of a platysma flap cranially. Exposure of the sternocleidomastoid and omohyoid muscles. Exposure of the nervus accessorius and the cervical vascular sheath. Free preparation of the internal jugular vein and removal of the neck block II a to V a, sparing the plexus branches. With the exception of the external jugular vein, all structures can be preserved. Switch to the opposite side. Here you can already feel a rough swelling and an immobile sternocleidomastoid muscle from the outside. Skin incision in the usual manner. Depiction of the sternocleidomastoid muscle in the caudal region. In the cranial region, the tumor can just be detached from the platysma, but no longer from the sternocleidomastoid muscle. It was therefore decided to remove the muscle in the lower part, cut through the sternocleidomastoid muscle and expose the cervical sheath. Detachment of the neck preparation from level V a cranially, in the area of the internal jugular vein/ facial vein angle, the metastasis cannot be detached from the internal jugular vein, so the decision is made to detach the vein in front of it. Detachment of the metastasis including the neck block. In the upper part, first expose and ligate the internal jugular vein at the base of the skull. Detachment of the neck block with the metastasis while sparing the internal and external carotid artery. The internal carotid artery has a pronounced kinking in the upper area, but can be completely spared; the hypoglossal nerve can also be completely spared. The upper part of the cervical plexus branches must also be removed as well as the accessorius nerve. Hemostasis by means of bipolar coagulation. Wound irrigation and insertion of drains and double wound closure on both sides. Performance of the tracheotomy by . () First palpation of the thyroid and cricoid cartilage, horizontal skin incision at the level of the cricoid cartilage and dissection in depth under palpatory control up to the thyroid gland. Exposure of the thyroid isthmus, undermining of the same and transection using bipolar coagulation. Subsequent meticulous hemostasis using bipolar coagulation. Blunt dissection of the trachea, after another palpatory check, incision of the trachea between the 2nd and 3rd cartilage, widening of the incision laterally while protecting the cuff of the inserted tube. Subsequently suture for tracheotomy in the typical manner. Check again for hemostasis, which is present. Skin suturing to narrow the skin incision and completion of the tracheostomy without any indication of complications. Subsequent two-layer wound closure of the neck dissection on both sides, after repeated bipolar coagulation on the right side there is now hemostasis. Connection of the Redon drains. Problem-free intubation with the help of the anesthesia colleagues to a size 8 tracheostomy tube, suturing of the same and completion of the procedure without any indication of complications after head repositioning by the first surgeon. Sterile wound dressing. \ No newline at end of file diff --git a/373/InvasionFront_CD3_block5_x5_y11_patient373_0.json b/373/InvasionFront_CD3_block5_x5_y11_patient373_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8e208ad1fc3d39d9c92139d6bd77fa3c0bc5f1b9 --- /dev/null +++ b/373/InvasionFront_CD3_block5_x5_y11_patient373_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16317.1, + "Centroid Y µm": 28141.6, + "Num Detections": 21513, + "Num Negative": 19449, + "Num Positive": 2064, + "Positive %": 9.594, + "Num Positive per mm^2": 860.2 + } +} \ No newline at end of file diff --git a/373/InvasionFront_CD3_block5_x6_y11_patient373_1.json b/373/InvasionFront_CD3_block5_x6_y11_patient373_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3456fd671073e8041b84532a90997f1f0baec182 --- /dev/null +++ b/373/InvasionFront_CD3_block5_x6_y11_patient373_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 28085.1, + "Num Detections": 22216, + "Num Negative": 21055, + "Num Positive": 1161, + "Positive %": 5.226, + "Num Positive per mm^2": 509.53 + } +} \ No newline at end of file diff --git a/373/InvasionFront_CD8_block5_x5_y9_patient373_0.json b/373/InvasionFront_CD8_block5_x5_y9_patient373_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8403c82bf382e735b8e338250cbd7079390f5ad4 --- /dev/null +++ b/373/InvasionFront_CD8_block5_x5_y9_patient373_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 22538.1, + "Num Detections": 25421, + "Num Negative": 24518, + "Num Positive": 903, + "Positive %": 3.552, + "Num Positive per mm^2": 326.25 + } +} \ No newline at end of file diff --git a/373/InvasionFront_CD8_block5_x6_y9_patient373_1.json b/373/InvasionFront_CD8_block5_x6_y9_patient373_1.json new file mode 100644 index 0000000000000000000000000000000000000000..594b1f7a9f7f5518c820b2357f604887491c9abc --- /dev/null +++ b/373/InvasionFront_CD8_block5_x6_y9_patient373_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 22513.1, + "Num Detections": 27904, + "Num Negative": 27496, + "Num Positive": 408, + "Positive %": 1.462, + "Num Positive per mm^2": 143.43 + } +} \ No newline at end of file diff --git a/373/TumorCenter_CD3_block5_x5_y9_patient373_0.json b/373/TumorCenter_CD3_block5_x5_y9_patient373_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5e21370e624332708d8d2e6ead49976c64915991 --- /dev/null +++ b/373/TumorCenter_CD3_block5_x5_y9_patient373_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 22762.9, + "Num Detections": 26624, + "Num Negative": 24838, + "Num Positive": 1786, + "Positive %": 6.708, + "Num Positive per mm^2": 612.95 + } +} \ No newline at end of file diff --git a/373/TumorCenter_CD3_block5_x6_y9_patient373_1.json b/373/TumorCenter_CD3_block5_x6_y9_patient373_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e44facc12adc1de453031746e014716f18aefd51 --- /dev/null +++ b/373/TumorCenter_CD3_block5_x6_y9_patient373_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 23087.8, + "Num Detections": 26705, + "Num Negative": 24613, + "Num Positive": 2092, + "Positive %": 7.834, + "Num Positive per mm^2": 712.77 + } +} \ No newline at end of file diff --git a/373/TumorCenter_CD8_block5_x5_y9_patient373_0.json b/373/TumorCenter_CD8_block5_x5_y9_patient373_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7b7e40c4855211f459f97f52eb79075116a5cef3 --- /dev/null +++ b/373/TumorCenter_CD8_block5_x5_y9_patient373_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 22513.1, + "Num Detections": 26713, + "Num Negative": 26146, + "Num Positive": 567, + "Positive %": 2.123, + "Num Positive per mm^2": 193.19 + } +} \ No newline at end of file diff --git a/373/TumorCenter_CD8_block5_x6_y9_patient373_1.json b/373/TumorCenter_CD8_block5_x6_y9_patient373_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1c00475744aeb6acbc500664990f38e5515de3b9 --- /dev/null +++ b/373/TumorCenter_CD8_block5_x6_y9_patient373_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 22563.1, + "Num Detections": 27582, + "Num Negative": 26712, + "Num Positive": 870, + "Positive %": 3.154, + "Num Positive per mm^2": 294.25 + } +} \ No newline at end of file diff --git a/373/history_text.txt b/373/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/373/icd_codes.txt b/373/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adab28f0b88ba31c5bb4895a3d4f3034f2967b3e --- /dev/null +++ b/373/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] \ No newline at end of file diff --git a/373/ops_codes.txt b/373/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6295d8cabf3b0ffa43f9373e5ac64e63be61c8c1 --- /dev/null +++ b/373/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] Temporäre Tracheotomie[5-311.0 ] Anwendung eines komplexen OP-Roboters (Zusatzkode)[5-987.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/373/patient_clinical_data.json b/373/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..844804ae1d3a3c09cb3426dc776054d5966bdf94 --- /dev/null +++ b/373/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/373/patient_pathological_data.json b/373/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..64126be1ba56024cd112cc9ca721b8e8c83729ea --- /dev/null +++ b/373/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "373", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/373/surgery_description.txt b/373/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..86b373f356bf523dbd7d5717efedface6771afe1 --- /dev/null +++ b/373/surgery_description.txt @@ -0,0 +1 @@ +Robot-assisted tumor resection on the right, Left neck dissection, Tracheotomy diff --git a/373/surgery_report.txt b/373/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..42a429be7f1deb60bf8b37916c5a5d9bd76a83e9 --- /dev/null +++ b/373/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation using a laser tube by the anesthesia colleagues. Then insertion of the Da Vinci retractor and inspection of the tumor region. A 2-3 cm large tumor is found at the lower pole of the tonsil with transition to the base of the tongue. The robotic arms are then advanced and tumor resection begins at the cranial edge. The tumor is cut around, taking most of the tonsil and part of the base of the tongue and the glossotonsillar fold with it. Basally, the soft tissues of the neck are reached very far, so that the neck fat and also parts of the submandibular gland are exposed and pulsating vessels are palpable and visible through the fat. For this reason, a neck dissection is not performed in this procedure, as otherwise a thorough defect would occur. Due to the extent of the defect and recurrent bleeding during the tumor resection, the decision was made to perform a small tracheotomy. First, however, the neck dissection was performed on the left side by . For this, skin incision in the usual manner. Exposure of the sternocleidomastoid muscle. Exposure of the submandibular gland. Exposure of the digastric muscle. Exposure of the omohyoid muscle. Showing the cervical vascular sheath. Exposure of the accessorius nerve, hypoglossus and cervical anus. Then evacuation of levels IIa to IV while sparing the plexus branches. Insertion of a Redon drainage and two-layer wound closure. Finally, the tracheotomy is performed in the usual manner. For this, skin incision below the cricoid cartilage. Dissection down to the thyroid isthmus. Dissection of the thyroid isthmus. Exposure of the anterior wall of the trachea and creation of a visor tracheotomy between the 2nd and 3rd tracheal cartilage. Creation of a mucocutaneous anastomosis and reintubation to a 9 mm tracheal cannula. The patient was admitted to the intensive care unit postoperatively and was given a nasogastric tube to be fed for 5 days. Then TE diet and planning of neck dissection on the right side after 3-4 weeks. \ No newline at end of file diff --git a/374/InvasionFront_CD3_block16_x3_y4_patient374_0.json b/374/InvasionFront_CD3_block16_x3_y4_patient374_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d62cc1979452ad21a0b3c85d392c69a40d341322 --- /dev/null +++ b/374/InvasionFront_CD3_block16_x3_y4_patient374_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11802.8, + "Centroid Y µm": 14473.0, + "Num Detections": 17073, + "Num Negative": 16875, + "Num Positive": 198, + "Positive %": 1.16, + "Num Positive per mm^2": 76.15 + } +} \ No newline at end of file diff --git a/374/InvasionFront_CD3_block16_x4_y4_patient374_1.json b/374/InvasionFront_CD3_block16_x4_y4_patient374_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cc92125466c7f3beba6eae301e34ca5092bbec22 --- /dev/null +++ b/374/InvasionFront_CD3_block16_x4_y4_patient374_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14464.3, + "Centroid Y µm": 14483.8, + "Num Detections": 19136, + "Num Negative": 18789, + "Num Positive": 347, + "Positive %": 1.813, + "Num Positive per mm^2": 129.49 + } +} \ No newline at end of file diff --git a/374/InvasionFront_CD8_block16_x3_y4_patient374_0.json b/374/InvasionFront_CD8_block16_x3_y4_patient374_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6e98b646f829313b9affdb7022d73e74a8406cea --- /dev/null +++ b/374/InvasionFront_CD8_block16_x3_y4_patient374_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11085.3, + "Centroid Y µm": 9926.7, + "Num Detections": 18538, + "Num Negative": 18131, + "Num Positive": 407, + "Positive %": 2.195, + "Num Positive per mm^2": 155.37 + } +} \ No newline at end of file diff --git a/374/InvasionFront_CD8_block16_x4_y4_patient374_1.json b/374/InvasionFront_CD8_block16_x4_y4_patient374_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a43f5bfd2ecafaaec04bfcbbcda920ede353bdc9 --- /dev/null +++ b/374/InvasionFront_CD8_block16_x4_y4_patient374_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13737.0, + "Centroid Y µm": 10098.4, + "Num Detections": 21353, + "Num Negative": 20817, + "Num Positive": 536, + "Positive %": 2.51, + "Num Positive per mm^2": 195.55 + } +} \ No newline at end of file diff --git a/374/TumorCenter_CD3_block16_x3_y4_patient374_0.json b/374/TumorCenter_CD3_block16_x3_y4_patient374_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b233bd43d605ebf9ad58d6721409d8dccd7137e --- /dev/null +++ b/374/TumorCenter_CD3_block16_x3_y4_patient374_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12068.6, + "Centroid Y µm": 10294.5, + "Num Detections": 17813, + "Num Negative": 17586, + "Num Positive": 227, + "Positive %": 1.274, + "Num Positive per mm^2": 87.75 + } +} \ No newline at end of file diff --git a/374/TumorCenter_CD3_block16_x4_y4_patient374_1.json b/374/TumorCenter_CD3_block16_x4_y4_patient374_1.json new file mode 100644 index 0000000000000000000000000000000000000000..249fc981ab2552ec7360828b1d9b38e82e818220 --- /dev/null +++ b/374/TumorCenter_CD3_block16_x4_y4_patient374_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14692.2, + "Centroid Y µm": 10369.5, + "Num Detections": 22326, + "Num Negative": 20821, + "Num Positive": 1505, + "Positive %": 6.741, + "Num Positive per mm^2": 535.54 + } +} \ No newline at end of file diff --git a/374/TumorCenter_CD8_block16_x3_y4_patient374_0.json b/374/TumorCenter_CD8_block16_x3_y4_patient374_0.json new file mode 100644 index 0000000000000000000000000000000000000000..06e4b9643e2c726d088fadac78be58c3e36e8964 --- /dev/null +++ b/374/TumorCenter_CD8_block16_x3_y4_patient374_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10969.2, + "Centroid Y µm": 10319.5, + "Num Detections": 19120, + "Num Negative": 18822, + "Num Positive": 298, + "Positive %": 1.559, + "Num Positive per mm^2": 113.33 + } +} \ No newline at end of file diff --git a/374/TumorCenter_CD8_block16_x4_y4_patient374_1.json b/374/TumorCenter_CD8_block16_x4_y4_patient374_1.json new file mode 100644 index 0000000000000000000000000000000000000000..898e8c18bf6d5e2cf918944667a40c67d6af40b2 --- /dev/null +++ b/374/TumorCenter_CD8_block16_x4_y4_patient374_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 10244.6, + "Num Detections": 21969, + "Num Negative": 21006, + "Num Positive": 963, + "Positive %": 4.383, + "Num Positive per mm^2": 348.71 + } +} \ No newline at end of file diff --git a/374/history_text.txt b/374/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fd5b260745e58ef576bc4a4cb56de2b52f391873 --- /dev/null +++ b/374/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 cN2b G2 oral cavity carcinoma in the area of the right edge of the tongue was histologically confirmed during a panendoscopy <2013>. In addition, moderately differentiated circumscribed esophageal carcinoma. After endoscopic mucosal resection of the esophageal carcinoma by the colleagues in internal medicine, the indication for primary surgical treatment of the oral cavity carcinoma was made. Preoperative imaging revealed a cT2-cT3 cN2b oral cavity carcinoma on the right. \ No newline at end of file diff --git a/374/icd_codes.txt b/374/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..86d6e9b2875a9442f15551633537b8dab9f94820 --- /dev/null +++ b/374/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Mund sonstige und onA mehrere Teilbereiche überlappend[C06.8 ] \ No newline at end of file diff --git a/374/ops_codes.txt b/374/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..13d3b6eeabf9a13f94fbd7287305d324e92698ad --- /dev/null +++ b/374/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.x0 ] Permanente Tracheotomie[5-312.0 ] Anlegen einer PEG[5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] \ No newline at end of file diff --git a/374/patient_clinical_data.json b/374/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b09e735dad0d0aa2e43d9ba6ab1128169c0952e7 --- /dev/null +++ b/374/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 54, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 58, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/374/patient_pathological_data.json b/374/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ab7d1c8f29b24fb554cc438317e22537da45e5a2 --- /dev/null +++ b/374/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "374", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN2a", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 12, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/374/surgery_description.txt b/374/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d646651e3da4a12cd6f576abeace163b750861f --- /dev/null +++ b/374/surgery_description.txt @@ -0,0 +1 @@ +Pharyngeal partial resection, PEG placement, Tracheotomy, PE (Proximal esophagus) diff --git a/374/surgery_report.txt b/374/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..186d15dbe87e3a01bcc80d20e45cb3324fcb1ecb --- /dev/null +++ b/374/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Start of PEG insertion: For this purpose, insertion with the gastroscope under laryngoscopic control. Problem-free pre-laryngoscopy into the stomach. Excellent diaphanoscopy. Problem-free puncture of the stomach. Subsequent problem-free PEG insertion using the usual suture pull-through method. The esophagus is inconspicuous on the endoscopy and regular postoperatively. The primary tumor region is now inspected: an exophytic mass measuring approx. 4x2 cm with transition to the lateral floor of the mouth and a small tumor extension towards the anterior floor of the mouth can be seen in the area of the free edge of the tongue on the right. In addition, the glossotonsillar groove is reached. The tonsil is rough and scarred with a questionable tumor extension into the tonsil region. After radical exposure of the tumor, successive resection is performed with sufficient macroscopic safety margin. The tumor is resected using an electric needle and dissection technique. The tumor has grown relatively superficially with hardly any deep infiltrations in the area of the tongue and the floor of the mouth. Basally, a sufficient safety margin was maintained on all sides and successive resection was performed, including the free edge of the tongue on the right and the floor of the mouth with partial resection of the sublingual and submandibular gland. The transition to the base of the tongue itself is again free. Removal of the glossotonsillar groove and, in the case of a questionable tumor extension into the tonsil, removal of the tonsil with subtotal removal of the anterior palatal arch. Hemostasis by means of bipolar coagulation and ligation of stronger vessels. The tumor is now macroscopically visible on the specimen in sano-resected form. Slightly narrower margin in the area of the anterior floor of the mouth. A basal and anterior resection is performed here. The tumor is now completely imaged with margin samples. Residual carcinoma can be seen just submucosally in the area of the anterior floor of the mouth. In addition, CIS in the area of the lateral floor of the mouth and in the area of the dorsum of the tongue. Low-grade dysplasia in the area of the soft palate without higher-grade dysplasia, also in the intraoperative reclassification. A generous resection is now performed in the area of the anterior floor of the mouth and re-covered with a marginal specimen. Additional resection in the area of the lateral floor of the mouth and in the area of the edge of the tongue. The anterior floor of the mouth is now tumor-free with no high-grade dysplasia, the tongue margin is free with only minor dysplasia and CIS remains in the area of the lateral floor of the mouth. A new resection is performed here. CIS with additional evidence of invasive carcinoma is also seen here. Therefore, sharp incision of the alveolar ridge mucosa. Incision down to the periosteum. Removal of the entire mucosa and obtaining a generous, flat resection, which is then resected in a thread-oriented manner for frozen section diagnostics. The carcinoma in situ is found to have been removed in sano. Therefore, an R0 situation can be assumed overall. Due to the extensive enoral soft tissue defect involving the submandibular gland, a simultaneous neck dissection is not performed in this session. Also due to the extensive wound area and incipient swelling tendency, a supporting tracheotomy is performed. For this purpose, a horizontal skin incision is made below the cricoid cartilage. Cut through the skin and subcutaneous tissue. Expose the infrahyoid musculature. Entering the linea alba. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea and transection of the thyroid isthmus. Insertion between the 1st and 2nd tracheal ring. Creation of a broad-based pedicled Björk flap and insertion of the tracheostoma. Subsequent easy intubation with a size 8 low cuff cannula, followed by careful and repeated irrigation of the enoral wound area. Meticulous hemostasis and termination of the procedure at this point if the enoral conditions are dry. Conclusion: Intraoperative R0-resected at least cT2 cN2b oral cavity carcinoma on the right with extensive perifocal dysplasia and perifocal CIS. Overall, extensive field carcinomatization can also be assumed here. The necessary neck dissection on both sides should be planned in the 2nd session in approx. 2 weeks. Primary secondary wound healing should initially be aimed for enorally. With proper enoral healing and proper food build-up, prompt decannulation should be possible. Postoperative consultation with the anesthesiologist. \ No newline at end of file diff --git a/375/InvasionFront_CD3_block18_x5_y5_patient375_0.json b/375/InvasionFront_CD3_block18_x5_y5_patient375_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8fc2ca580397196b13c9aafb570c56de5181e540 --- /dev/null +++ b/375/InvasionFront_CD3_block18_x5_y5_patient375_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 17540.7, + "Num Detections": 10353, + "Num Negative": 10147, + "Num Positive": 206, + "Positive %": 1.99, + "Num Positive per mm^2": 133.68 + } +} \ No newline at end of file diff --git a/375/InvasionFront_CD3_block18_x6_y5_patient375_1.json b/375/InvasionFront_CD3_block18_x6_y5_patient375_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e99e6aea942870475f0c3b7a37ab6c11b03209e3 --- /dev/null +++ b/375/InvasionFront_CD3_block18_x6_y5_patient375_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 17615.7, + "Num Detections": 6153, + "Num Negative": 5869, + "Num Positive": 284, + "Positive %": 4.616, + "Num Positive per mm^2": 273.58 + } +} \ No newline at end of file diff --git a/375/InvasionFront_CD8_block18_x5_y5_patient375_0.json b/375/InvasionFront_CD8_block18_x5_y5_patient375_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c0c3c8acd49e7b96550de9a0e3285cb15751ee5f --- /dev/null +++ b/375/InvasionFront_CD8_block18_x5_y5_patient375_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 20314.2, + "Num Detections": 11245, + "Num Negative": 11046, + "Num Positive": 199, + "Positive %": 1.77, + "Num Positive per mm^2": 131.05 + } +} \ No newline at end of file diff --git a/375/InvasionFront_CD8_block18_x6_y5_patient375_1.json b/375/InvasionFront_CD8_block18_x6_y5_patient375_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3a3d0635d5ea7d7f8e51f84190de6c92d70ed63 --- /dev/null +++ b/375/InvasionFront_CD8_block18_x6_y5_patient375_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 20164.3, + "Num Detections": 9328, + "Num Negative": 8957, + "Num Positive": 371, + "Positive %": 3.977, + "Num Positive per mm^2": 291.55 + } +} \ No newline at end of file diff --git a/375/TumorCenter_CD3_block18_x5_y5_patient375_0.json b/375/TumorCenter_CD3_block18_x5_y5_patient375_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3475747bdd8c449077d442cf2f5aef16b1755033 --- /dev/null +++ b/375/TumorCenter_CD3_block18_x5_y5_patient375_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 12243.5, + "Num Detections": 18861, + "Num Negative": 18811, + "Num Positive": 50, + "Positive %": 0.2651, + "Num Positive per mm^2": 25.02 + } +} \ No newline at end of file diff --git a/375/TumorCenter_CD3_block18_x6_y5_patient375_1.json b/375/TumorCenter_CD3_block18_x6_y5_patient375_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a7d173bbcc6847f7573d53b54db03719c145d79d --- /dev/null +++ b/375/TumorCenter_CD3_block18_x6_y5_patient375_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18190.4, + "Centroid Y µm": 12318.5, + "Num Detections": 18358, + "Num Negative": 18341, + "Num Positive": 17, + "Positive %": 0.0926, + "Num Positive per mm^2": 8.863 + } +} \ No newline at end of file diff --git a/375/TumorCenter_CD8_block18_x5_y5_patient375_0.json b/375/TumorCenter_CD8_block18_x5_y5_patient375_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1861ca59cebe8e6523091995449812703e345072 --- /dev/null +++ b/375/TumorCenter_CD8_block18_x5_y5_patient375_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 12968.1, + "Num Detections": 12509, + "Num Negative": 11754, + "Num Positive": 755, + "Positive %": 6.036, + "Num Positive per mm^2": 511.39 + } +} \ No newline at end of file diff --git a/375/TumorCenter_CD8_block18_x6_y5_patient375_1.json b/375/TumorCenter_CD8_block18_x6_y5_patient375_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3e078595d81773e5b42b2fdda104ee4dba844656 --- /dev/null +++ b/375/TumorCenter_CD8_block18_x6_y5_patient375_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18190.4, + "Centroid Y µm": 13118.1, + "Num Detections": 11031, + "Num Negative": 10620, + "Num Positive": 411, + "Positive %": 3.726, + "Num Positive per mm^2": 294.54 + } +} \ No newline at end of file diff --git a/375/history_text.txt b/375/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5577139238dcf6a0756251491603c3e68cd55f7a --- /dev/null +++ b/375/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the endolarynx. Laryngectomy now indicated for extensive findings. Hence the above-mentioned procedure. \ No newline at end of file diff --git a/375/ops_codes.txt b/375/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8ae008bdfabd1aec7c6d0ccde762db5a3c51525a --- /dev/null +++ b/375/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] \ No newline at end of file diff --git a/375/patient_clinical_data.json b/375/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..476ddc850472d37a01a549872d299fc44e8256b2 --- /dev/null +++ b/375/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 45, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/375/patient_pathological_data.json b/375/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..461c9a1e09714f6e190b01a7958aca4108b8c367 --- /dev/null +++ b/375/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "375", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 60, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file