diff --git a/682/ops_codes.txt b/682/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8958394c00779b0fc771d67a6a80c489f470335c --- /dev/null +++ b/682/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-296.14 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.48 R] Permanente Tracheotomie[5-312.0 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 B] Perkutan-endoskopische Gastrostomie[5-431.2 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] \ No newline at end of file diff --git a/682/surgery_description.txt b/682/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b60e28aaf906410e8eca27311880f13e3430df48 --- /dev/null +++ b/682/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Defect reconstruction, Free flap (ALT), Neck dissection diff --git a/682/surgery_report.txt b/682/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e7036f7726253ba506add6ad2527f6328a76664e --- /dev/null +++ b/682/surgery_report.txt @@ -0,0 +1 @@ +First re-inspect after positioning the patient. Inspection with the Kleinsasser tube. There is an exophytic mass in the area of the right tonsil lobe, passing over the soft palate to the parauvular area, filling the entire right tonsil lobe, transition to the posterior pharyngeal wall, the mass extends caudally in the area of the lateral pharyngeal wall to the hypopharyngeal level and ends just below the vallecula. The right edge of the epiglottis is just reached. Growth over the glossotonsillar groove towards the tongue, but no tongue infiltration here. The first step is transoral resection of the oral cavity, resection of the soft palate including the uvula and approximately half of the soft palate, resection of the entire tonsil lobe including the pharyngeal muscles down to the soft tissues of the neck. Resection and removal at the posterior floor of the mouth, taking the glossotonsillar groove with it. Covering of the soft palate and the posterior floor of the mouth with marginal samples, which are shown to be tumor-free in the frozen section diagnosis. Now reposition for neck dissection of the right side. A skin incision is made on the anterior edge of the sternocleidomastoid muscle, skin and subcutaneous tissue is cut, the platysma is cut, the external jugular vein and auricular nerve are exposed and preserved. Exposure of the sternocleidomastoid muscle, omohyoid muscle and digastric muscle. Exposure and preservation of the facial vein. Removal of the anterior neck preparation with careful protection and preservation of the superior thyroid artery, the hypoglossal nerve and the cervical vein. Free preparation of the internal jugular vein, exposure and preservation of the accessorius nerve, removal of the accessorius triangle and removal of level Va up to the border to Vb while carefully preserving the cervical plexus roots. Overall, no peritoneal growing metastases in the neck area. The glandula submandibularis is now extirpated and the neck dissection of neck level Ib is completed. Enter enorally via the posterior floor of the mouth. Then skeletonize the hyoid on the right side. Enter the pharynx into the vallecula cavity. Widen the pharyngotomy towards the pharyngeal side wall. Successive widening. Inclusion of the free epiglottis margin on the right, good overview of the tumor. Successive detachment, exposure and preservation of the superior laryngeal nerve. Exposure and skeletonization of the hypoglossal nerve and the lingual artery, both of which can be preserved. Exposure and preservation of the facial artery. Successive resection of the tumor with a safety margin, removal of the right lateral part of the base of the tongue to ensure the safety margin and removal of the tumor macroscopically in toto, which is thread-reinforced for definitive histology. Somewhat narrow conditions in the area of the posterior cranial pharyngeal wall on the specimen. A separate resection is therefore performed here. Similarly, if the macroscopic conditions are somewhat scarce in the direction of the vallecula, a resection is made here. Subsequently, the entire tumor is covered with marginal samples, which are completely tumor-free, with no evidence of higher-grade dysplasia; only in the area of the posterior edge of the tongue are there low to moderate-grade dysplasia. After discussing the case with the pathology department, a definitive marginal sample is taken. If the R0 situation is now present intraoperatively, the defect is measured. Performing defect reconstruction with microvascularly anastomosed ALT from the right after Doppler sonographic identification of the main perforator, here marking a graft measuring 14 x 7 cm in total. First medial incision. Exposure and identification of the rectus femoris muscle, subfascial release, exposure of the pedicle vessel. Exposure of the main perforator. Free preparation of the perforator. In case of musculocutaneous course, complete isolation of the perforator and overall configuration of the graft as a perforator flap. Partial preservation of the fascia lata around the perforator, otherwise lateral thinning of the flap. Isolation via the perforator to the vascular pedicle and placement of the excellent vital graft after isolation of the pedicle vessels. Final hemostasis. Insertion of a 10-gauge Redon drain and careful multi-layer wound closure with resection of excess skin. Neck dissection of the left side was performed at the same time. This also involved cutting through the skin and subcutaneous tissue and exposing the sternocleidomastoid and omohyoid muscles, releasing the submandibular gland and taking the caudal capsule with it. Exposure of the digastric muscle. Exposure and preservation of the facial vein, removal of the anterior neck preparation with preservation of the cervical artery, superior thyroid artery and hypoglossal nerve. Free dissection of the internal jugular vein, exposure and preservation of the accessorius nerve and, while preserving the accessorius triangle, limitation of the neck dissection in the direction of the level Va. Dissection up to the cervical plexus, which is carefully protected. Final wound irrigation and, if the wound is dry, insertion of a 10-gauge Redon drain and careful wound closure. The graft is then incorporated, combined transoral and transcervical graft suturing under difficult conditions with a complex defect. Overall, however, good fit and intact conditions on all sides. Conditioning of the superior thyroid artery, arterial anastomosis with 8-0 Ethilon, this is sufficient. Immediately good venous return with clearly leading strong vein. Conditioning of the facial vein, measurement of a coupler size 3.0 and performance of the venous anastomosis with the coupler system. Subsequent regular pedicle pulsation. Positive spreading phenomenon and vital graft enorally. No significant outflow via the second small vein, so that this is closed. Subsequent careful wound inspection and, if the wound is dry, insertion of a 10-gauge Redon drain and careful two-layer wound closure. The tracheotomy is then performed. Skin incision below the cricoid cartilage, separation of skin and subcutaneous tissue. Exposure and transection of the infrahyoid musculature. Exposure of the cricoid cartilage, exposure of the anterior surface of the trachea, transection of the thyroid isthmus. Insertion between the 1st and 2nd tracheal rings, creation of a broad-based Björk flap and incision of the tracheostoma in the typical manner. Subsequent problem-free transfer to a size 8 low cuff cannula, which is suture-fixed. The procedure was then completed with a vital graft and no indication of complications. Endoscopic PEG placement was performed at the beginning of the procedure. This was done with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach. With good diaphanoscopy, the stomach was punctured without any problems. The PEG tube is then inserted using the usual suture pull-through method. Note: The patient receives intraoperative intravenous antibiotics with Unacid 3 g, which should be continued for 24 hours postoperatively. Conclusion: Intraoperative R0 resected cT3 cN2b G2 cM0 oropharyngeal carcinoma on the right. If the graft and wound healed properly postoperatively, please perform an X-ray breischluck on the 10th postoperative day. Due to the size of the defect, a prolonged recovery of swallowing function can be expected. Adjuvant therapy is certainly necessary. \ No newline at end of file diff --git a/683/TumorCenter_CD8_block17_x4_y5_patient683_1.json b/683/TumorCenter_CD8_block17_x4_y5_patient683_1.json new file mode 100644 index 0000000000000000000000000000000000000000..546aa09de43cef1f1d3ad0bcbd693dffbfc07055 --- /dev/null +++ b/683/TumorCenter_CD8_block17_x4_y5_patient683_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 26186.1, + "Num Detections": 24450, + "Num Negative": 24247, + "Num Positive": 203, + "Positive %": 0.8303, + "Num Positive per mm^2": 73.55 + } +} \ No newline at end of file diff --git a/683/history_text.txt b/683/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..99a53858eeec37f4126f4693e6c05e758deac767 --- /dev/null +++ b/683/history_text.txt @@ -0,0 +1 @@ +Patient with cT1b glottic laryngeal carcinoma on the right side. Due to the lack of adjustability and the main tumor mass in the area of the anterior commissure, there is now an indication for a partial laryngectomy from the outside. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/683/icd_codes.txt b/683/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b8056349bf7d1f1a5acc73d65b6b09b6b4e86af --- /dev/null +++ b/683/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 B] \ No newline at end of file diff --git a/683/ops_codes.txt b/683/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dff177eb8da18afbce99e9f2df4b59384f52331d --- /dev/null +++ b/683/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] \ No newline at end of file diff --git a/683/patient_clinical_data.json b/683/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5529b199b2177eb7db176d8c7b49ac43f8c43a9b --- /dev/null +++ b/683/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 9, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/683/surgery_description.txt b/683/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..47c829a6e106fb5193cf24426359d948740014b4 --- /dev/null +++ b/683/surgery_description.txt @@ -0,0 +1 @@ +Partial resection of larynx (Leroux-Robert) from the outside via thyreofissure diff --git a/683/surgery_report.txt b/683/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6d331788857b45f57b0b73f34f8cfa1038a475a6 --- /dev/null +++ b/683/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with anesthesia colleagues. Induction of anesthesia and intubation of the patient. Positioning of the patient by the surgeon. Skin spray disinfection and infiltration anesthesia. Skin wipe disinfection and sterile draping. First mark the planned incision after palpatory identification of the thyroid incisura and the upper edge of the cricoid cartilage. Make the incision using the broken-line technique. Sharp cutting of the cutis as well as the subcutis. Expose the prelaryngeal musculature. Locate the median line. Lateralization of the prelaryngeal musculature and exposure of the thyroid cartilage. Insertion of the sharp retractors. Incise the periosteum from the thyroid incisura to the lower edge of the thyroid cartilage. Dissection of 2 perichondrium lobules and lateralization of the same. Horizontal incision of the ligamentum conicum. Incision with the wheel and opening of the laryngeal skeleton in the median line. A tumor can now be seen extending from the right vocal process via the anterior commissure to the middle third of the left vocal fold. Initially beginning on the right side. First infiltration anesthesia glottic right. Then resection of the right vocal fold, including the vocal ligament, the vocalis muscle and parts of the thyroarytenoid muscle. In some cases, it is necessary to resect down to the perichondrium of the inner surface of the thyroid cartilage. The same procedure is also carried out on the left side. Here the resection only extends to the posterior third, taking the middle third with it. Here too, the extent of the resection is carried out via the vocal ligament and the vocalis muscle to the arytaenoid muscle. In the ventral part of the resection area, resection is also performed down to the inner perichondrium leaf of the thyroid cartilage. This is followed by hemostasis using bipolar coagulation. Removal of circular margin samples. Right: upper front, upper back, lower back, lower front; left: upper front, upper back, lower back, lower front. During the telephone frozen section examination, extensions of a squamous cell carcinoma in situ can still be seen subglottically on the right. Therefore, a definitive resection and a new marginal sample are taken and also sent for frozen section diagnostics. This is found to be tumor-free intraoperatively. Therefore, proceed to closure of the larynx. Creation of a total of 4 drill holes. Insertion of a 14 mm laryngeal wedge. Suturing with Vicryl 4.0. Creation of 2 additional drill holes to achieve adequate closure of the laryngeal skeleton. Closure of the incision in the area of the ligamentum conicum. Mobilization of the two perichondrium flaps. These are folded over the Keel and sutured in the median line. Overall very good aspect. Insertion of a sterile flap. Re-adaptation of the prelaryngeal musculature. This is also sutured with Vicryl 4.0 in the median line. Prior to this, wound irrigation with H2O2 and Ringer's solution. Subcutaneous suturing with Vicryl 4.0 and skin suturing with Ethilon 5.0. Application of a wound dressing and a wrap and completion of the operation without complications after a final consultation with the anesthesia colleagues. \ No newline at end of file diff --git a/684/InvasionFront_CD8_block19_x3_y12_patient684_0.json b/684/InvasionFront_CD8_block19_x3_y12_patient684_0.json new file mode 100644 index 0000000000000000000000000000000000000000..215b21edbbd492fd43b57c5ab8a1b33e23ea3c87 --- /dev/null +++ b/684/InvasionFront_CD8_block19_x3_y12_patient684_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 39686.8, + "Num Detections": 20914, + "Num Negative": 20791, + "Num Positive": 123, + "Positive %": 0.5881, + "Num Positive per mm^2": 53.55 + } +} \ No newline at end of file diff --git a/684/InvasionFront_CD8_block19_x4_y12_patient684_1.json b/684/InvasionFront_CD8_block19_x4_y12_patient684_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ac082138b8277c020f8dc533f41418f906a6633 --- /dev/null +++ b/684/InvasionFront_CD8_block19_x4_y12_patient684_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13510.1, + "Centroid Y µm": 39836.8, + "Num Detections": 19401, + "Num Negative": 19364, + "Num Positive": 37, + "Positive %": 0.1907, + "Num Positive per mm^2": 16.22 + } +} \ No newline at end of file diff --git a/684/TumorCenter_CD3_block19_x3_y12_patient684_0.json b/684/TumorCenter_CD3_block19_x3_y12_patient684_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad73560e1bef986852c8e6d915a533d13e66fcd6 --- /dev/null +++ b/684/TumorCenter_CD3_block19_x3_y12_patient684_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13819.3, + "Centroid Y µm": 30858.4, + "Num Detections": 9857, + "Num Negative": 9684, + "Num Positive": 173, + "Positive %": 1.755, + "Num Positive per mm^2": 87.3 + } +} \ No newline at end of file diff --git a/684/TumorCenter_CD3_block19_x4_y12_patient684_1.json b/684/TumorCenter_CD3_block19_x4_y12_patient684_1.json new file mode 100644 index 0000000000000000000000000000000000000000..391a67aa03bf2199de8498f7109631aba36b12b0 --- /dev/null +++ b/684/TumorCenter_CD3_block19_x4_y12_patient684_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16353.9, + "Centroid Y µm": 30551.6, + "Num Detections": 12650, + "Num Negative": 12210, + "Num Positive": 440, + "Positive %": 3.478, + "Num Positive per mm^2": 212.83 + } +} \ No newline at end of file diff --git a/684/TumorCenter_CD8_block19_x3_y12_patient684_0.json b/684/TumorCenter_CD8_block19_x3_y12_patient684_0.json new file mode 100644 index 0000000000000000000000000000000000000000..063a3ec92105b56847be90848f26e90da61f6a4f --- /dev/null +++ b/684/TumorCenter_CD8_block19_x3_y12_patient684_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 41203.2, + "Num Detections": 11320, + "Num Negative": 11283, + "Num Positive": 37, + "Positive %": 0.3269, + "Num Positive per mm^2": 26.64 + } +} \ No newline at end of file diff --git a/684/TumorCenter_CD8_block19_x4_y12_patient684_1.json b/684/TumorCenter_CD8_block19_x4_y12_patient684_1.json new file mode 100644 index 0000000000000000000000000000000000000000..82eb6cf6f344d3c02d5acf283b085b9da8583034 --- /dev/null +++ b/684/TumorCenter_CD8_block19_x4_y12_patient684_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 41378.1, + "Num Detections": 19023, + "Num Negative": 18811, + "Num Positive": 212, + "Positive %": 1.114, + "Num Positive per mm^2": 99.22 + } +} \ No newline at end of file diff --git a/684/history_text.txt b/684/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..64ac080b1186cfae398422f456d6a9d8bd59836c --- /dev/null +++ b/684/history_text.txt @@ -0,0 +1 @@ +The patient had a T1a glottic carcinoma on the right side. Due to the extremely poor adjustability of the tumor, a partial laryngeal resection from the outside was indicated. \ No newline at end of file diff --git a/684/icd_codes.txt b/684/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/684/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/684/ops_codes.txt b/684/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5b508f4d896241bc9f7875f26c433bfac8e53f15 --- /dev/null +++ b/684/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] \ No newline at end of file diff --git a/684/patient_clinical_data.json b/684/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0f28d324749d1c1d4b77513639138a6620c46899 --- /dev/null +++ b/684/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 6, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/684/patient_pathological_data.json b/684/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d79f344351cfb233465ca3c599d387327ec7bb4f --- /dev/null +++ b/684/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "684", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/684/surgery_description.txt b/684/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..12a9bb604f37c6694e2290e1a933163700168644 --- /dev/null +++ b/684/surgery_description.txt @@ -0,0 +1 @@ +Partial resection of larynx diff --git a/684/surgery_report.txt b/684/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c36d7853fd10c8c9ebdce3df2ff548dc990d198a --- /dev/null +++ b/684/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Intubation of the patient. Application of local anesthesia. Transverse skin incision over the larynx. Dissection in layers down to the prelaryngeal muscles. This is cut in the midline and dissected to the side. Exposure of the thyroid cartilage plate. Exposure of the cricoid cartilage. Exposure of the ligamentum conicum. Opening of the ligamentum conicum in the sense of a transverse incision. Opening of the thyroid cartilage in the midline with the wheel. Insertion of the retractors. It can be seen that the tumor reaches right up to the anterior commissure, but does not appear to exceed it. The anterior commissure has thus been opened beyond the tumor. Nevertheless, a marginal sample was taken from the left anterior commissure. Subsequent re-inspection of the tumor. This is easily displaceable in relation to the thyroid cartilage. Therefore, the tumor, which reaches the vocal process here and can be removed there, was cut around. In the upper area, the tumor does not reach the pocket fold. Only slight infiltration of the subglottic slope towards the lower margin. The tumor is macroscopically resected in sano on all sides. Removal of marginal samples from the upper and lower margins of the deposit as well as separately from the front and deep front. Together with the margin sample from the opposite side, these are sent for frozen section examination. Based on the intraoperative findings, the R0 resection is confirmed by pathology. Subtle hemostasis. The tube had been removed orotracheally during the operation and the patient had been reintubated to an endolaryngeal tube from the outside. Using the Seldinger technique, reintubation to an orotracheal tube at the end of the operation with a dry wound. Then closure of the larynx with two mattress sutures and suturing of the ligamentum conicum. Insertion of a wound flap. Closure of the prelaryngeal muscles in the midline. Continuous suture here. Two-layer wound closure. Application of a pressure dressing. Final consultation with the anesthetist. Completion of the procedure. \ No newline at end of file diff --git a/685/InvasionFront_CD3_block19_x5_y10_patient685_0.json b/685/InvasionFront_CD3_block19_x5_y10_patient685_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5e2add8c540ac3de92b2fb17df686c3ce73532a0 --- /dev/null +++ b/685/InvasionFront_CD3_block19_x5_y10_patient685_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 27460.5, + "Num Detections": 15854, + "Num Negative": 15646, + "Num Positive": 208, + "Positive %": 1.312, + "Num Positive per mm^2": 133.71 + } +} \ No newline at end of file diff --git a/685/InvasionFront_CD3_block19_x6_y10_patient685_1.json b/685/InvasionFront_CD3_block19_x6_y10_patient685_1.json new file mode 100644 index 0000000000000000000000000000000000000000..91da30135e7cc79c319a6ee6569cd50c772c4160 --- /dev/null +++ b/685/InvasionFront_CD3_block19_x6_y10_patient685_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 27710.3, + "Num Detections": 18794, + "Num Negative": 18422, + "Num Positive": 372, + "Positive %": 1.979, + "Num Positive per mm^2": 205.47 + } +} \ No newline at end of file diff --git a/685/InvasionFront_CD8_block19_x5_y10_patient685_0.json b/685/InvasionFront_CD8_block19_x5_y10_patient685_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f7823218a8f04ab5d7afc9bef0bb8b457b16e352 --- /dev/null +++ b/685/InvasionFront_CD8_block19_x5_y10_patient685_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 35131.4, + "Num Detections": 16190, + "Num Negative": 16091, + "Num Positive": 99, + "Positive %": 0.6115, + "Num Positive per mm^2": 54.87 + } +} \ No newline at end of file diff --git a/685/InvasionFront_CD8_block19_x6_y10_patient685_1.json b/685/InvasionFront_CD8_block19_x6_y10_patient685_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b801766203df2862ed21def0fc521f77dc95f2c1 --- /dev/null +++ b/685/InvasionFront_CD8_block19_x6_y10_patient685_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 35306.3, + "Num Detections": 25395, + "Num Negative": 25282, + "Num Positive": 113, + "Positive %": 0.445, + "Num Positive per mm^2": 41.31 + } +} \ No newline at end of file diff --git a/685/TumorCenter_CD3_block19_x5_y10_patient685_0.json b/685/TumorCenter_CD3_block19_x5_y10_patient685_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f162baba74e50f2ad9944743994e9957a92848cb --- /dev/null +++ b/685/TumorCenter_CD3_block19_x5_y10_patient685_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18277.4, + "Centroid Y µm": 25390.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/685/TumorCenter_CD3_block19_x6_y10_patient685_1.json b/685/TumorCenter_CD3_block19_x6_y10_patient685_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b65d96712e0b48e68662578c88c2cd3018c21495 --- /dev/null +++ b/685/TumorCenter_CD3_block19_x6_y10_patient685_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20890.8, + "Centroid Y µm": 25160.1, + "Num Detections": 20912, + "Num Negative": 20479, + "Num Positive": 433, + "Positive %": 2.071, + "Num Positive per mm^2": 189.5 + } +} \ No newline at end of file diff --git a/685/TumorCenter_CD8_block19_x5_y10_patient685_0.json b/685/TumorCenter_CD8_block19_x5_y10_patient685_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2dcf97914a83b3c0d8ef9a0659635be7f1e65b68 --- /dev/null +++ b/685/TumorCenter_CD8_block19_x5_y10_patient685_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 36180.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/685/TumorCenter_CD8_block19_x6_y10_patient685_1.json b/685/TumorCenter_CD8_block19_x6_y10_patient685_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c7101dea990170011cde08264f74fd7643c2013e --- /dev/null +++ b/685/TumorCenter_CD8_block19_x6_y10_patient685_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21388.7, + "Centroid Y µm": 36405.7, + "Num Detections": 17698, + "Num Negative": 17481, + "Num Positive": 217, + "Positive %": 1.226, + "Num Positive per mm^2": 111.59 + } +} \ No newline at end of file diff --git a/685/history_text.txt b/685/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d41ad8d7bd950bac398bbfc38d074b9c1165f3e2 --- /dev/null +++ b/685/history_text.txt @@ -0,0 +1 @@ +The patient has been suffering from dysphonia for 4 months. Mirror findings revealed an exophytic mass in the area of the right glottis with transition to the supraglottis. The vocal fold mobility on the right side is clearly immobile to fixed. Sampling during panendoscopy <2016> revealed a G2 squamous cell carcinoma with CT-morphologically questionable infiltration of the right arytenoid cartilage. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/685/icd_codes.txt b/685/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/685/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/685/ops_codes.txt b/685/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ac662321ee0eb3c2b5eccc406f775cc1b14fa18d --- /dev/null +++ b/685/ops_codes.txt @@ -0,0 +1 @@ +Laserresektion Larynxgewebe mit Stützlaryngoskopie[5-302.5 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Temporäre Tracheotomie[5-311.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/685/patient_clinical_data.json b/685/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bf715eb13df82edb20fbb26261bce5369059ec30 --- /dev/null +++ b/685/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 84, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/685/patient_pathological_data.json b/685/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..940a023ffe7ee14451b219aa71c13e2e0383bc45 --- /dev/null +++ b/685/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "685", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/685/surgery_description.txt b/685/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ff204108ebdbec442f4565f3fbfba22e524f3d4 --- /dev/null +++ b/685/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Neck dissection, Tracheotomy diff --git a/685/surgery_report.txt b/685/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2b9f3e1dd326f94d94f20b4dd832609a1992bc8b --- /dev/null +++ b/685/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia and intubation by the anesthesia colleagues. Entry with the Kleinsasser tube and inspection of the tumor. The tumor completely infiltrates the right vocal fold, passes into the anterior commissure and infiltrates two thirds of the left vocal fold, it grows supraglottically and infiltrates the entire pocket fold on the right side and two thirds of the pocket fold on the left side. The mucosa at the vocal process is also infiltrated. Mechanically, the ary on the right side is still mobile with the small double spoon, but less mobile than on the left side. Demonstration of the findings on and . It is decided to first resect the mucosa in the area of the posterior artery and send it for a frozen section. This is also done. The patient also has a rather benign cyst postcricoid on the right side. This cyst is also removed with the scissors and sent for frozen section. The frozen section showed no evidence of carcinoma in either specimen, so the decision was made to continue with the laser resection and to forgo a complete laryngectomy for the time being. Now loosening and removal of the tumor on the posterior surface, then repositioning and removal of the tumor in the area of the anterior commissure. This is relatively difficult as the patient cannot be adjusted well at the anterior commissure. Finally, the tumor is successfully released there. It must be completely lasered off the thyroid cartilage. Infiltration of the thyroid cartilage is not present on CT morphology or clinically. Then first resection of the tumor portion on the left side. Here, half of the pocket fold on the vocal fold falls. It is clear that the tumor is also growing approximately 0.5 cm into the subglottic appendix on both the right and left sides. Here, too, resection is necessary. Finally, the tumor is also resected on the right side, including the pocket fold and the subglottic slope for 0.5 cm. The arytenoid cartilage can be preserved, but the mucosa in the area of the vocal process must be completely resected. The specimen is placed on cork for final histology. Subsequently, marginal samples are taken subglottically on both sides as well as centrally, then in the area of both pocket folds and the posterior margins. All marginal samples are R0 in the frozen section. The entire surface of the tumor is covered by the margin samples and an R0 resection can be assumed. Then repositioning for neck dissection on the right side. For this, the skin incision is made relatively caudally in a skin fold that extends up to the mastoid. It is theoretically possible to extend this skin incision to the apron flap in a second operation if a functional laryngectomy should become necessary. Now the platysma is shown. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Then release of the neck preparation level II a to IV while sparing the plexus branches. Tearing of the internal jugular vein occurs in level II, which is sutured over with Vascufil 6.0. Then consultation with . The latter was cautious about the overall indication for neck dissection in this procedure, so the neck dissection on the left side was not performed. Repositioning for tracheotomy. Perform the tracheotomy in the usual manner with formation of a mucocutaneous anastomosis in the sense of a visor tracheotomy. Then transfer intubation to a tracheostomy tube 8.0. Then insertion of a nasogastric tube. Please present the patient at the tumor conference after receiving the final histology, to plan any adjuvant therapy. No oral food for 5 days, then attempt to swallow and build up diet, if necessary speech therapy swallowing training. As he was able to remain standing on the right side and on the left side, swallowing should not cause any problems in the long term, if no adjuvant therapy is necessary, please have a control MLE in 10 to 12 weeks. If there is clear granulation tissue, then remove the granulation tissue and possibly insert a Dacron foil or PDS foil secondarily. \ No newline at end of file diff --git a/686/InvasionFront_CD3_block15_x1_y7_patient686_0.json b/686/InvasionFront_CD3_block15_x1_y7_patient686_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c589f528e376667aa3cc0ed1ce10be66fcc431a0 --- /dev/null +++ b/686/InvasionFront_CD3_block15_x1_y7_patient686_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 28010.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/686/InvasionFront_CD3_block15_x2_y7_patient686_1.json b/686/InvasionFront_CD3_block15_x2_y7_patient686_1.json new file mode 100644 index 0000000000000000000000000000000000000000..06fa580588408fc5fc524aa6007c001b1591d526 --- /dev/null +++ b/686/InvasionFront_CD3_block15_x2_y7_patient686_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8695.4, + "Centroid Y µm": 27835.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/686/InvasionFront_CD8_block15_x1_y7_patient686_0.json b/686/InvasionFront_CD8_block15_x1_y7_patient686_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b67ec70709707872587e5a31e00948973707917c --- /dev/null +++ b/686/InvasionFront_CD8_block15_x1_y7_patient686_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3904.3, + "Centroid Y µm": 17523.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/686/InvasionFront_CD8_block15_x2_y7_patient686_1.json b/686/InvasionFront_CD8_block15_x2_y7_patient686_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c5b97b1b1df17260f670e5bd1ceff657db114710 --- /dev/null +++ b/686/InvasionFront_CD8_block15_x2_y7_patient686_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6566.8, + "Centroid Y µm": 17338.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/686/TumorCenter_CD3_block15_x1_y7_patient686_0.json b/686/TumorCenter_CD3_block15_x1_y7_patient686_0.json new file mode 100644 index 0000000000000000000000000000000000000000..81320ef88ae1b794fdb09f9d6e42e93c91d4aeac --- /dev/null +++ b/686/TumorCenter_CD3_block15_x1_y7_patient686_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 20938.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/686/TumorCenter_CD3_block15_x2_y7_patient686_1.json b/686/TumorCenter_CD3_block15_x2_y7_patient686_1.json new file mode 100644 index 0000000000000000000000000000000000000000..64da9599110aac55e57ab3bcd86f15f8b9dbe711 --- /dev/null +++ b/686/TumorCenter_CD3_block15_x2_y7_patient686_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 20938.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/686/TumorCenter_CD8_block15_x1_y7_patient686_0.json b/686/TumorCenter_CD8_block15_x1_y7_patient686_0.json new file mode 100644 index 0000000000000000000000000000000000000000..33c1c5f726476911e4634378aa0c67cba938e25e --- /dev/null +++ b/686/TumorCenter_CD8_block15_x1_y7_patient686_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 17465.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/686/TumorCenter_CD8_block15_x2_y7_patient686_1.json b/686/TumorCenter_CD8_block15_x2_y7_patient686_1.json new file mode 100644 index 0000000000000000000000000000000000000000..241b65cbad5e93f3258578cf52232f9ce0a2ebfe --- /dev/null +++ b/686/TumorCenter_CD8_block15_x2_y7_patient686_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8870.3, + "Centroid Y µm": 17465.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/686/history_text.txt b/686/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f939256dca8e7725b70b696a39da4f28402ad429 --- /dev/null +++ b/686/history_text.txt @@ -0,0 +1 @@ +Mr. is diagnosed with primary carcinoma of the tongue margin on the left. Preoperative MRI and PET-CT image diagnostics indicated a CUP syndrome with a large metastasis in the caudal parotid region. A gross needle puncture was performed in domo 4 weeks ago in LA. A metastasis at the lower parotid pole was biopsied and a squamous cell carcinoma was confirmed. Now, due to a small ulcer on the left edge of the tongue, a primary tumor in the oral cavity is suspected. Therefore indication for intraoperative panendoscopy and frozen section biopsy of the suspected ulcer as well as the procedure described above. \ No newline at end of file diff --git a/686/icd_codes.txt b/686/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..acd06601482e09b106b052b50397b569ef7704da --- /dev/null +++ b/686/icd_codes.txt @@ -0,0 +1 @@ +Sekundäre und nicht näher bezeichnete bösartige Neubildung: Lymphknoten des Kopfes, des Gesichtes und des Halses[C77.0 ] Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/686/ops_codes.txt b/686/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e13b0fdb78d1ea59c4803836bbb1dbd1efee3243 --- /dev/null +++ b/686/ops_codes.txt @@ -0,0 +1 @@ +Parotidektomie partiell mit intraoperativem Fazialismonitoring[5-262.01 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] Partielle Glossektomie transoral sonstige[5-251.0x ] Exzision erkranktes Gewebe Zunge[5-250.2 ] Plastische Rekonstruktion Zunge[5-253.1 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/686/patient_clinical_data.json b/686/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..919c499a614561ca74b626a9172b2d9055705a22 --- /dev/null +++ b/686/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/686/patient_pathological_data.json b/686/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8da0c7cefa6cc25b19fdd54af2cfcb44f54640bb --- /dev/null +++ b/686/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "686", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.5 +} \ No newline at end of file diff --git a/686/surgery_description.txt b/686/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f7e8624a023f5e7daea8ab6ca1aa1360da0c3e9 --- /dev/null +++ b/686/surgery_description.txt @@ -0,0 +1 @@ +SS-controlled resection of tongue edge, Neck dissection, Parotid, PEG, Panendoscopy diff --git a/686/surgery_report.txt b/686/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d90d2e96179474363d18f06ceb375d6304f27d9c --- /dev/null +++ b/686/surgery_report.txt @@ -0,0 +1 @@ +Anesthesia is first induced by the anesthesia colleague. A rigid tracheobronchoscopy is then performed by the 1st surgeon. There is no evidence of a secondary tumor in the area of the glottis, subglottis and trachea up to the entrance of the main bronchi. Intubation by the surgeon and head positioning. Next, a flexible gastroscopy is performed. The flexible gastroscope is advanced into the stomach under constant air insufflation. Inspection of the stomach reveals non-irritable mucosal conditions with a very pronounced small gastric curvature. After inspection of all areas of the stomach, the esophagus is thoroughly examined from caudal to cranial with the flexible gastroscope. Linea serrata inconspicuous at 42 cm from the upper alveolar ridge. The caudal middle and cranial part of the esophagus is completely clinically unremarkable. Removal of the flexible gastroscope and insertion of the size B small bore tube. The oral cavity and oropharynx are inspected. In the area of the glossotonsillar groove on the left edge of the tongue, a small ulcer of at least 1-1.5 cm in diameter is seen, which is relatively coarse on palpation and grows into the tongue muscles. Other areas of the oropharynx such as the base of the tongue, vallecula, both tonsils, posterior pharyngeal wall and lateral pharyngeal wall are completely unremarkable. A biopsy is then taken from the ulcers described above and the tissue is sent for frozen section examination. A direct pharyngoscopy and inspection of the supraglottis using a size C Kleinsasser tube is also performed. The hypopharynx (piriform sinus on both sides and retrocricodal area) and supraglottis showed normal anatomical conditions with no evidence of a secondary malignancy. Removal of the size C small siphon tube without injury to the oral structures. After waiting for the frozen section diagnosis, a histology in the sense of a squamous cell carcinoma is confirmed. Next, a PEG is placed with classic sutures. The next step is to resect the tumor on the left edge of the tongue. Here, a distance of 1 to 1.2 cm from the ulcer is made clinically as well as a relatively deep excision in the tongue musculature. The specimen is then thread-marked. In addition, a sample is taken from the tumor bed; a strip is cut from the tongue musculature and sent separately for histological analysis. Careful hemostasis using bipolar forceps. No evidence of injury to the great vessels in the sense of the lingual artery. The patient is then repositioned for neck dissection and left parotidectomy. Skin disinfection. Application of 4 electrodes for monitoring the facial nerve. Infiltration of the subcutis using 10 ml mixed solution of Suprarenin and Ultracaine. Sterile washing and covering. Insertion of a skin incision from the jugulum to the mastoid on the left. Dissection in depth and sharp cutting of the subcutis and platysma. At the cranial edge of the incision, a portion of the skin above the parotid gland, where a coarse needle biopsy was performed, is included in the preparation. Next, lift off the subplatysmal flap anteriorly and cranially as well as laterally and posteriorly. Identification of the external jugular vein and auricular nerve. Both structures enter the mass cranially so that both structures are ligated and separated approx. 5 cm from the caudal metastasis. Then identify the superficial cervical fascia and further dissect from lateral to medial. Dissection is then carried out in the level IV area, where a complete clearing of level IV is performed. During the dissection, the artery and transverse vein of the neck are exposed and spared, but a branch of the thoracic duct is exposed and injured. Intraoperatively, intrathoracic pressure is then increased and the open vessel is found and then additionally ligated. Further control with artificial Valsalva shows no evidence of lymphorrhea. Then successive dissection from caudal to cranial with sparing of the cervical plexus. Further dissection from caudal to cranial until the large metastasis is identified in level IIa, IIb and the cranial part of level V. This metastasis is at least 6 cm in diameter and is obviously growing into the sternocleidomastoid muscle and internal jugular vein as well as the caudal parotid region. After clearing level III, level I is then cleared successively from caudal and anterior to cranial and posterior, sparing the submandibular gland. Cranially, the ramus marginalis mandibulae is exposed and completely spared. Dissection practically up to the caudal area level IIa, here complete adhesion of the internal jugular vein as well as the accessorius nerve and sternocleidomastoid muscle can be seen. Next, a partial parotidectomy is performed under facial nerve monitoring from cranial and anterior to posterior and caudal. A distance of at least 1-2 cm is maintained from the large parotid metastasis. After dissection at the anterior parotid margin, the ramus marginalis mandibulae and a pronounced buccal branch are visualized. These are now followed in a retrograde course under constant facial stimulation. Successive dissection from the periphery to the center until the cervicofacial ramus and then the facial nerve are identified. The facial nerve and its branches, although relatively close to the mass, are not fused with the mass. The main cords of the facial nerve are carefully and completely exposed here and completely spared and shifted cranially. Here there is clear adhesion of the metastasis at the base of the sternocleidocleidomastoid muscle and level V between the sternocleidomastoid and trapezius muscles. Here, sharp dissection up to the tip of the mastoid and complete separation of the insertion from the mastoid. Further dissection deep into level Va until the prevertebral muscles (splenius and levator scapulae muscles) are identified. Here further dissection caudally and anteriorly until identification of the R. and N. accessorius at the posterior edge of the sternocleidomastoid muscle. Careful inspection of level II and affected structures. Decision to perform a radical neck resection, as the metastasis is clearly growing on the above-mentioned structures. Next, the sternocleidomastoid muscle is sharply separated at the transition from the cranial to the middle 1/3. Careful coagulation at the edge of the detachment. The accessorius nerve is ligated and sharply separated. The internal jugular vein is then ligated and sutured twice and then sharply separated. Dissection along the common carotid artery and external and internal carotid artery in a cranial direction. Exposure of the hypoglossal nerve, vagus nerve and symptomatic trunk in the carotid space. Branches of the cervical plexus in the area of level II are also sharply dissected. Now dissect further anteriorly and include the facial vein and the posterior edge of the masseter muscle at the posterior edge of the mandible. Dissection deep into the masseteric space, here the metastasis grows together practically up to the base of the skull. Further sharp separation of the metastasis from the external and internal carotid artery along the cervical vascular sheath. Now demonstration on and takeover of the operation. The metastasis is now first dissected sharply at the base of the skull along the internal and external carotid artery. In the further course, clear adhesion of the metastasis to the external carotid artery and questionable infiltration of the hypoglossal nerve and internal carotid artery. Successive separation of the remainder of the metastasis at the base of the skull above the atlas and lateral to the styloid process. Due to severe bleeding in the area of the stylomastoid foramen, the main trunk of the facial nerve is coagulated but not severed. Here, stimulation of the main branch results in a complete nerve block approx. 0.5 cm from the stylomastoid foramen. The main branch of the facial nerve can be completely stimulated with 0.5 mA from this nerve block. Decision to ligate the external carotid artery and resection of the hypoglossal nerve and internal carotid artery to the base of the skull. Neck dissection together with the parotid leaf is sent in one piece for histological analysis, level Ia and level IV are marked separately with the suture for orientation. Next, dissection along the external carotid artery. This is ligated twice caudally after the exit of the superior thyroid vein and then punctured and sharply separated. The third branch of the lingual artery is also ligated twice and then sharply separated. The third branch of the external carotid artery, facial artery, is also ligated twice and sharply separated. The remainder of the external carotid artery is then traced together with the hypoglossal nerve and sharply separated from the carotid fascia and from the vagus nerve and internal carotid artery. This preparation is sent separately for histological analysis. A large defect remains at the base of the skull from the jugular fossa over the petrous bone to the carotid foramen. The wound is then thoroughly irrigated and careful hemostasis with ligation and bipolar electrocoagulation. The remainder of the sternocleidomatoid muscle is sutured to the platysma to reconstruct the neck contour. Two size 10 Redon drains are inserted caudally. The facial nerve trunk is carefully covered with Tabotamp. Careful wound closure. Redon drainage is inspected again, it works perfectly. The defect on the left edge of the tongue is now inspected. Relatively dry conditions here. Due to R0 frozen section diagnostics, a decision is made to close the wound primarily. Careful primary closure and plastic reconstruction of the defect at the edge of the tongue on the left is performed. If the swelling at the uvula and base of the tongue is relatively mild, the decision is made to transfer the patient to the IOI for overnight monitoring. The patient is then handed over to the anesthesiologist. End of the surgical procedure. Conclusion: Complication-free performance of a rapid incision-controlled resection of the tongue margin carcinoma on the left, extended radical neck dissection from level I to level V on the left and partial parotidectomy with intraoperative facial nerve monitoring and PEG placement. Panendoscopy revealed a left tongue ulcer, so that a diagnosis was confirmed via frozen section. Intraoperative a metastasis growing from the caudal parotid pole to the skull base and levels IIa, IIb and V. Difficult conditions in the area of the skull base due to adhesions to the external carotid artery and questionable adhesions to the internal carotid artery. Overall an unsafe resection in the area of the internal carotid artery and skull base. An R1 situation is possible here. The accessorius nerve, internal jugular vein, cranial edge of the sternocleidomastoid muscle, hypoglossal nerve, external carotid artery and cranial part of the cervical plexus and cranial part of the sympathetic plexus are sacrificed intraoperatively. Postoperative radiotherapy should always be carried out if infiltration of the internal carotid artery is questionable. Rapid and aggressive rehabilitation due to shoulder function as well as speech and swallowing due to hypoglossal sacrifice and sacrifice of the accessory nerve. Cortisone therapy tapered off for the next 7 days due to injury to the main facial nerve trunk. The facial nerve should be given at least 6-12 months to recover. Redon ex please after progression. Further procedure and presentation of the patient to the tumor board after receipt of the final histology. One night of monitoring for IOI due to slight swelling at the base of the tongue and uvula. \ No newline at end of file diff --git a/687/InvasionFront_CD3_block20_x3_y9_patient687_0.json b/687/InvasionFront_CD3_block20_x3_y9_patient687_0.json new file mode 100644 index 0000000000000000000000000000000000000000..45961aca8f04c896042f52adcda498f67ad93e96 --- /dev/null +++ b/687/InvasionFront_CD3_block20_x3_y9_patient687_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11568.9, + "Centroid Y µm": 22238.2, + "Num Detections": 17960, + "Num Negative": 13989, + "Num Positive": 3971, + "Positive %": 22.11, + "Num Positive per mm^2": 1831.1 + } +} \ No newline at end of file diff --git a/687/InvasionFront_CD3_block20_x4_y9_patient687_1.json b/687/InvasionFront_CD3_block20_x4_y9_patient687_1.json new file mode 100644 index 0000000000000000000000000000000000000000..167758a0362bafd83083a663239e335028284f1c --- /dev/null +++ b/687/InvasionFront_CD3_block20_x4_y9_patient687_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14092.5, + "Centroid Y µm": 22563.1, + "Num Detections": 17882, + "Num Negative": 15272, + "Num Positive": 2610, + "Positive %": 14.6, + "Num Positive per mm^2": 1298.3 + } +} \ No newline at end of file diff --git a/687/InvasionFront_CD8_block20_x3_y9_patient687_0.json b/687/InvasionFront_CD8_block20_x3_y9_patient687_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e7e3a4d5b155d5479db78cbedab4575c4995f0b5 --- /dev/null +++ b/687/InvasionFront_CD8_block20_x3_y9_patient687_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12188.4, + "Centroid Y µm": 22613.9, + "Num Detections": 14436, + "Num Negative": 7986, + "Num Positive": 6450, + "Positive %": 44.68, + "Num Positive per mm^2": 3579.7 + } +} \ No newline at end of file diff --git a/687/InvasionFront_CD8_block20_x4_y9_patient687_1.json b/687/InvasionFront_CD8_block20_x4_y9_patient687_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f144be32dbdfa6e6ff3b177be834e2ef3d2652ea --- /dev/null +++ b/687/InvasionFront_CD8_block20_x4_y9_patient687_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14442.4, + "Centroid Y µm": 22513.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/687/TumorCenter_CD3_block20_x3_y9_patient687_0.json b/687/TumorCenter_CD3_block20_x3_y9_patient687_0.json new file mode 100644 index 0000000000000000000000000000000000000000..143d7f5d52271fa334f1fffa7d7d2e95a3ff2048 --- /dev/null +++ b/687/TumorCenter_CD3_block20_x3_y9_patient687_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11137.5, + "Centroid Y µm": 21628.1, + "Num Detections": 14838, + "Num Negative": 11926, + "Num Positive": 2912, + "Positive %": 19.63, + "Num Positive per mm^2": 1298.6 + } +} \ No newline at end of file diff --git a/687/TumorCenter_CD3_block20_x4_y9_patient687_1.json b/687/TumorCenter_CD3_block20_x4_y9_patient687_1.json new file mode 100644 index 0000000000000000000000000000000000000000..50d4e54d2f55cbc38920b69ec9830edcca2df524 --- /dev/null +++ b/687/TumorCenter_CD3_block20_x4_y9_patient687_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13689.4, + "Centroid Y µm": 21624.9, + "Num Detections": 16514, + "Num Negative": 14792, + "Num Positive": 1722, + "Positive %": 10.43, + "Num Positive per mm^2": 822.28 + } +} \ No newline at end of file diff --git a/687/TumorCenter_CD8_block20_x3_y9_patient687_0.json b/687/TumorCenter_CD8_block20_x3_y9_patient687_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ff0229de7d362aea41f328e0362de63912d227b2 --- /dev/null +++ b/687/TumorCenter_CD8_block20_x3_y9_patient687_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 22663.0, + "Num Detections": 10392, + "Num Negative": 6380, + "Num Positive": 4012, + "Positive %": 38.61, + "Num Positive per mm^2": 2898.8 + } +} \ No newline at end of file diff --git a/687/TumorCenter_CD8_block20_x4_y9_patient687_1.json b/687/TumorCenter_CD8_block20_x4_y9_patient687_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a30911a38b336d1cc72e4e1e172c32bbbde9238 --- /dev/null +++ b/687/TumorCenter_CD8_block20_x4_y9_patient687_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 22413.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/687/history_text.txt b/687/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..011f340c0241443b6ce7ce9402340a3e611f6b67 --- /dev/null +++ b/687/history_text.txt @@ -0,0 +1 @@ +During a panendoscopy, a glottic laryngeal carcinoma of the left side was confirmed in the patient, which extends close to the anterior commissure and occupies the entire glottis of the left side up to the infiltration of the pocket fold supraglottically. For this reason, the indication for the above procedure was given. \ No newline at end of file diff --git a/687/icd_codes.txt b/687/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/687/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/687/ops_codes.txt b/687/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5b508f4d896241bc9f7875f26c433bfac8e53f15 --- /dev/null +++ b/687/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] \ No newline at end of file diff --git a/687/patient_clinical_data.json b/687/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b0d0c4245dd4c00620485632a2858dc64349bdc4 --- /dev/null +++ b/687/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 76, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/687/patient_pathological_data.json b/687/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f7cbdade0f6f7377a2a6a1c454750721277507ca --- /dev/null +++ b/687/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "687", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 12, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/687/surgery_description.txt b/687/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9dcb9dc195e8ddc688e55d228e80fa987102fbe5 --- /dev/null +++ b/687/surgery_description.txt @@ -0,0 +1 @@ +Laryngeal partial resection diff --git a/687/surgery_report.txt b/687/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0e66fc77453b937ed59e91062f9a83b9bad1192 --- /dev/null +++ b/687/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Positioning of the patient. Abjoration of the skin, injection of local anesthetic without adrenaline. Ellipsoidal vertical skin incision prelaryngeal with resection of the old tracheotomy scar. Layered preparation in depth. Exposure of the prelaryngeal musculature. This is cut in the midline and dissected to the side. Exposure of the laryngeal skeleton. Further exposure of the ligamentum conicum. This is incised after saturation of the patient and the incision is extended laterally. Dissect the perichondrium from the laryngeal cartilage. This is opened in the median line with the wheel. Insertion of the retractor. Opening of the epithelium endolaryngeally. The tumor described above can be seen on the left side. A marginal sample is taken in the area of the anterior commissure. The tumor does not appear to cross the midline here. Dissection from ventral to the thyroid cartilage. Strict dissection of the thyroid cartilage. The tumor extends slightly subglottically and infiltrates the cranial pocket fold. Dorsally, the tumor extends to the arytenoid cartilage. The patient should therefore be intubated via the laryngofissure. The endolaryngeal tube is thread-armed and remains cranially in the area of the supraglottis. The resection is initially performed at the caudal edge of the sedimentation, slightly subglottic, from ventral to dorsal. Furthermore, resection of the tumor in the cranial deposition area with removal of the caudal part of the pouch ligament on the left side. In the dorsal area, the arytenoid cartilage is largely skeletonized and the resection is completed by removing the vocal process. The tumor specimen is sent for definitive histopathological assessment. Further frozen sections are taken from the caudal and cranial margins of the arytenoid process. Furthermore, removal of a marginal sample from the cranial edge of the deposit in the area of the pocket crease. Removal of marginal samples from the wound bed and removal of a subglottic marginal sample from the caudal margin. All marginal samples are sent for frozen section diagnostics and are diagnosed as tumor-free by the pathologist. Careful hemostasis is then performed. Suturing of a laryngeal wedge and closure of the laryngofissure after making a total of four drill holes. Suturing of the ligamentum conicum. Mobilization of soft tissue, which is closed prelaryngeally with single button sutures. Insertion of a wound flap. Repeated dissection of prelaryngeal fatty tissue. This is also sutured using single button sutures. Two-layer skin closure. Application of a pressure bandage. Final consultation with the anesthetist. Completion of the procedure. The patient is transferred to the in-house intensive care unit for monitoring. \ No newline at end of file diff --git a/688/InvasionFront_CD3_block13_x3_y7_patient688_0.json b/688/InvasionFront_CD3_block13_x3_y7_patient688_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8b75be663e9d1854f56a333fba8d46d312bac634 --- /dev/null +++ b/688/InvasionFront_CD3_block13_x3_y7_patient688_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10969.2, + "Centroid Y µm": 16566.2, + "Num Detections": 8154, + "Num Negative": 5387, + "Num Positive": 2767, + "Positive %": 33.93, + "Num Positive per mm^2": 2531.9 + } +} \ No newline at end of file diff --git a/688/InvasionFront_CD3_block13_x4_y7_patient688_1.json b/688/InvasionFront_CD3_block13_x4_y7_patient688_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0c41165b06533b55ad88e9da9b517db1a2ffcedc --- /dev/null +++ b/688/InvasionFront_CD3_block13_x4_y7_patient688_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 16491.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/688/InvasionFront_CD8_block13_x3_y7_patient688_0.json b/688/InvasionFront_CD8_block13_x3_y7_patient688_0.json new file mode 100644 index 0000000000000000000000000000000000000000..20bfe3b322f43259f3dd34462ce1892e91c11b14 --- /dev/null +++ b/688/InvasionFront_CD8_block13_x3_y7_patient688_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12093.6, + "Centroid Y µm": 18215.4, + "Num Detections": 14417, + "Num Negative": 13175, + "Num Positive": 1242, + "Positive %": 8.615, + "Num Positive per mm^2": 659.03 + } +} \ No newline at end of file diff --git a/688/InvasionFront_CD8_block13_x4_y7_patient688_1.json b/688/InvasionFront_CD8_block13_x4_y7_patient688_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f4c1a174e2a61963977426936e0d406e1ce22383 --- /dev/null +++ b/688/InvasionFront_CD8_block13_x4_y7_patient688_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14667.2, + "Centroid Y µm": 18215.4, + "Num Detections": 3823, + "Num Negative": 3640, + "Num Positive": 183, + "Positive %": 4.787, + "Num Positive per mm^2": 344.32 + } +} \ No newline at end of file diff --git a/688/TumorCenter_CD3_block13_x3_y7_patient688_0.json b/688/TumorCenter_CD3_block13_x3_y7_patient688_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f40ab27d746a24c03f4ae5fa89e537dba1a2e9a6 --- /dev/null +++ b/688/TumorCenter_CD3_block13_x3_y7_patient688_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11818.7, + "Centroid Y µm": 23587.5, + "Num Detections": 11550, + "Num Negative": 8275, + "Num Positive": 3275, + "Positive %": 28.35, + "Num Positive per mm^2": 2141.3 + } +} \ No newline at end of file diff --git a/688/TumorCenter_CD3_block13_x4_y7_patient688_1.json b/688/TumorCenter_CD3_block13_x4_y7_patient688_1.json new file mode 100644 index 0000000000000000000000000000000000000000..70c7d8b56ce068bf62bdaa3e8896f10c400ca2a8 --- /dev/null +++ b/688/TumorCenter_CD3_block13_x4_y7_patient688_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14267.4, + "Centroid Y µm": 23862.4, + "Num Detections": 9822, + "Num Negative": 7220, + "Num Positive": 2602, + "Positive %": 26.49, + "Num Positive per mm^2": 1596.3 + } +} \ No newline at end of file diff --git a/688/TumorCenter_CD8_block13_x3_y7_patient688_0.json b/688/TumorCenter_CD8_block13_x3_y7_patient688_0.json new file mode 100644 index 0000000000000000000000000000000000000000..787d90ce95cfd5df8fdf30de1a273bb74b4f29d1 --- /dev/null +++ b/688/TumorCenter_CD8_block13_x3_y7_patient688_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12118.6, + "Centroid Y µm": 17365.8, + "Num Detections": 18021, + "Num Negative": 16496, + "Num Positive": 1525, + "Positive %": 8.462, + "Num Positive per mm^2": 700.98 + } +} \ No newline at end of file diff --git a/688/TumorCenter_CD8_block13_x4_y7_patient688_1.json b/688/TumorCenter_CD8_block13_x4_y7_patient688_1.json new file mode 100644 index 0000000000000000000000000000000000000000..871e5809d6f1b945e31570bd23cdbcaeffa81203 --- /dev/null +++ b/688/TumorCenter_CD8_block13_x4_y7_patient688_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14492.3, + "Centroid Y µm": 17066.0, + "Num Detections": 19065, + "Num Negative": 17561, + "Num Positive": 1504, + "Positive %": 7.889, + "Num Positive per mm^2": 637.26 + } +} \ No newline at end of file diff --git a/688/history_text.txt b/688/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/688/icd_codes.txt b/688/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..919e42e7d040845ce107696b7a8099347f7b70c0 --- /dev/null +++ b/688/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/688/ops_codes.txt b/688/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..93c6ff80d1a47ab4c0e37cc0bd4f79a06c7634c9 --- /dev/null +++ b/688/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Permanente Tracheostomaanlage[5-312.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Sonstige Entnahme und Transplantation sonstiges Transplantat mit mikrovaskuläre Anastomosierung Unterarm[5-858.x3 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Hemiglossektomie durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] \ No newline at end of file diff --git a/688/patient_clinical_data.json b/688/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ad528eb3aec864b2edba93580c55313de3666ff0 --- /dev/null +++ b/688/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 60, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/688/patient_pathological_data.json b/688/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..82a8149e553394319b177043ddc57c89d08e9b0b --- /dev/null +++ b/688/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "688", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN3b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/688/surgery_description.txt b/688/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a440de2db34d11ad56ae7e0183cc11d52f2b6f2b --- /dev/null +++ b/688/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection in the context of hemiglossectomy, Bilateral neck dissection, Radial flap, Tracheostomy, PEG placement diff --git a/688/surgery_report.txt b/688/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8c3abd252dfac5a4f3a07eccf81792badbf2b532 --- /dev/null +++ b/688/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, the PEG is first inserted without complications by and . The tracheostomy is then performed by and . A small tracheostoma is created and the patient is then easily intubated. Subsequently, transition to tumor resection transorally through and . After insertion of the mouth retractors, the tongue is first sutured to the tip of the tongue on the right and luxated outwards. The tumor located on the left edge of the tongue and the adjacent floor of the mouth can now be seen. On palpation, it extends to the midline in the posterior third of the tongue. The resection is then performed with the ultrasonic knife at an appropriate distance from the tumor, which is not easily palpable in the body of the tongue, especially in the dorsal area. The tumor is then gradually developed, whereby the resection also includes the adjacent floor of the mouth up to just before the ascending mandibular branch. Medially, the midline of the tongue is partially crossed in order to obtain a sufficient palpatory safety margin. In the dorsal direction, the resection can be moved laterally again at the beginning of the base of the tongue. The left half of the tongue is then completely resected. During the final inspection of the resection specimen, a suspicious area can be seen macroscopically on the underside, as the base of the tumor. This is test excised. Here, the frozen section diagnosis still reveals parts of the squamous cell carcinoma. Therefore, another extensive resection is performed in the area of the tumor base, so that the lingual artery on the opposite side is also left intact by the resection, but must be visualized. In this resection, there is no more tumor in the frozen section histology, so that an R0 resection can be assumed. The defect measures 11 x 6 cm. The radial lobe of and is also elevated at this size. Palpatory identification of the distal radial artery. Marking of the flap borders (6 x 11 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. In the meantime, selective neck dissection of regions I to V is performed on both sides. On the left side, the facial artery is dissected up to the mandible and the digastric muscle is severed. After appropriate lifting of the radial lobe graft, it is inserted into the defect via the submandibular lobe and sutured in place. The arterial anastomosis is performed at the confluence of the lingual artery and the facial artery, as only here is there sufficient caliber for anastomosis with the radial artery, which has a large caliber. After performing the arterial anastomosis, the venous anastomosis is performed with the 2 arm veins in an end-to-side manner to the internal jugular vein. Finally, multi-layer wound closure after insertion of a Redon suction drain and a drainage flap on the left side. Finally, the patient was reintubated onto an 8-gauge tracheostomy tube without any problems. The flap is vital at the end of the operation. End of the operation and transfer of the patient to anesthesia. Conclusion: Transoral resection of a tongue carcinoma on the left side in the sense of an extensive left-sided hemiglossectomy. Selective neck dissection of regions I to V on both sides, defect coverage with a microvascularly anastomosed radial flap graft from the left forearm with coverage by split skin from the right thigh, insertion of a PEG tube and a temporary tracheostomy. \ No newline at end of file diff --git a/689/InvasionFront_CD3_block7_x1_y7_patient689_0.json b/689/InvasionFront_CD3_block7_x1_y7_patient689_0.json new file mode 100644 index 0000000000000000000000000000000000000000..39f5ca0c81d84e210850e10370075bdfe798322f --- /dev/null +++ b/689/InvasionFront_CD3_block7_x1_y7_patient689_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4022.9, + "Centroid Y µm": 17091.0, + "Num Detections": 27429, + "Num Negative": 22960, + "Num Positive": 4469, + "Positive %": 16.29, + "Num Positive per mm^2": 1613.4 + } +} \ No newline at end of file diff --git a/689/InvasionFront_CD3_block7_x2_y7_patient689_1.json b/689/InvasionFront_CD3_block7_x2_y7_patient689_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bdca8c2374a7741a8b59960be1805cfd202e511d --- /dev/null +++ b/689/InvasionFront_CD3_block7_x2_y7_patient689_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 17041.0, + "Num Detections": 25537, + "Num Negative": 22667, + "Num Positive": 2870, + "Positive %": 11.24, + "Num Positive per mm^2": 1102.0 + } +} \ No newline at end of file diff --git a/689/InvasionFront_CD8_block7_x1_y7_patient689_0.json b/689/InvasionFront_CD8_block7_x1_y7_patient689_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f19b017ba64c53873349a77d8122aa9e4171403 --- /dev/null +++ b/689/InvasionFront_CD8_block7_x1_y7_patient689_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4722.5, + "Centroid Y µm": 17066.0, + "Num Detections": 25425, + "Num Negative": 17871, + "Num Positive": 7554, + "Positive %": 29.71, + "Num Positive per mm^2": 2814.5 + } +} \ No newline at end of file diff --git a/689/InvasionFront_CD8_block7_x2_y7_patient689_1.json b/689/InvasionFront_CD8_block7_x2_y7_patient689_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0df2a7095df248d2e2bf867506f430a7dcf1a348 --- /dev/null +++ b/689/InvasionFront_CD8_block7_x2_y7_patient689_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7496.0, + "Centroid Y µm": 17290.8, + "Num Detections": 26992, + "Num Negative": 24360, + "Num Positive": 2632, + "Positive %": 9.751, + "Num Positive per mm^2": 1039.5 + } +} \ No newline at end of file diff --git a/689/TumorCenter_CD3_block7_x1_y7_patient689_0.json b/689/TumorCenter_CD3_block7_x1_y7_patient689_0.json new file mode 100644 index 0000000000000000000000000000000000000000..32bbe26c6c05baa0a3f2172d3676fa60fd0ea54a --- /dev/null +++ b/689/TumorCenter_CD3_block7_x1_y7_patient689_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 17465.8, + "Num Detections": 24698, + "Num Negative": 19678, + "Num Positive": 5020, + "Positive %": 20.33, + "Num Positive per mm^2": 1849.8 + } +} \ No newline at end of file diff --git a/689/TumorCenter_CD3_block7_x2_y7_patient689_1.json b/689/TumorCenter_CD3_block7_x2_y7_patient689_1.json new file mode 100644 index 0000000000000000000000000000000000000000..61a29087b171e0fb700632a1b168fb5875c28e02 --- /dev/null +++ b/689/TumorCenter_CD3_block7_x2_y7_patient689_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 17640.7, + "Num Detections": 21316, + "Num Negative": 15670, + "Num Positive": 5646, + "Positive %": 26.49, + "Num Positive per mm^2": 2245.5 + } +} \ No newline at end of file diff --git a/689/TumorCenter_CD8_block7_x1_y7_patient689_0.json b/689/TumorCenter_CD8_block7_x1_y7_patient689_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ca8ac9f55c8ecc41bbb3dd0c33f883fde72a000f --- /dev/null +++ b/689/TumorCenter_CD8_block7_x1_y7_patient689_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3348.2, + "Centroid Y µm": 17465.8, + "Num Detections": 27896, + "Num Negative": 21340, + "Num Positive": 6556, + "Positive %": 23.5, + "Num Positive per mm^2": 2432.7 + } +} \ No newline at end of file diff --git a/689/TumorCenter_CD8_block7_x2_y7_patient689_1.json b/689/TumorCenter_CD8_block7_x2_y7_patient689_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6993ed2680355d01c67d80db87da9ad5b4c43d0f --- /dev/null +++ b/689/TumorCenter_CD8_block7_x2_y7_patient689_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5871.9, + "Centroid Y µm": 17615.7, + "Num Detections": 27123, + "Num Negative": 23477, + "Num Positive": 3646, + "Positive %": 13.44, + "Num Positive per mm^2": 1451.1 + } +} \ No newline at end of file diff --git a/689/history_text.txt b/689/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..12e1af101e202c3baa75d5946b82e1a10dc3af40 --- /dev/null +++ b/689/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 tonsillar carcinoma was histologically confirmed as the primary tumor in a clinically impressive, extensive and abscessing right cervical metastasis. Clear HPV association of the tumor. On CT cystic metastasis with extension into the tonsillar lobes on the right side. Overall cT2 cN2b cM0 oropharyngeal carcinoma on the right. \ No newline at end of file diff --git a/689/icd_codes.txt b/689/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2d7fc84bff07d6547fc3da21162d2d8a30244a4e --- /dev/null +++ b/689/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, nicht näher bezeichnet[C09.9 ] \ No newline at end of file diff --git a/689/ops_codes.txt b/689/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a025e8edc660aa275526245e74a6d1c7ef5f9417 --- /dev/null +++ b/689/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit gestieltem Fernlappen[5-296.05 ] Entnahme eines gestielten Fernlappens an der Schulter[5-904.26 R] Radikale Neck dissection in 5 Regionen[5-403.11 R] Selektive Neck dissection in 5 Regionen[5-403.04 L] Perkutan-endoskopische Gastrostomie[5-431.2 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/689/patient_clinical_data.json b/689/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fa271701fc0b926197477467b8449ca747929368 --- /dev/null +++ b/689/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 70, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/689/patient_pathological_data.json b/689/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5476fa594c22baeb69630828badcbcd7aec3fb68 --- /dev/null +++ b/689/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "689", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/689/surgery_description.txt b/689/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9a2035f2cfff26efd6fa04f78831f58c7d81ac34 --- /dev/null +++ b/689/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Pedicled flap (supraclavicular island flap), Tracheotomy, PEG placement diff --git a/689/surgery_report.txt b/689/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..88e4999bd03d5c69c55e8bf822febf66dcbb8dd7 --- /dev/null +++ b/689/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesia colleagues, an inspection of the primary tumor region is performed: Here, the primary tumor is submucosal in the area of the right tonsil lobe, circumscribed and extending into the soft palate, with moderate displacement towards the soft tissues of the neck. The submucosal tumor growth ends in the caudal area of the tonsil. Right cervical subcutaneously grown and clearly inflamed lymph node metastasis with subsequent puncture and open site. Due to the extent of the metastasis, PEG insertion was initially carried out: For this purpose, insertion with the gastroscope under laryngoscopic control. Easy to advance into the stomach. With good diaphanoscopy, easy puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. Subsequent transoral tumor resection: This is performed as an extended radical tumor tonsillectomy. Complete removal of the anterior floor of the mouth. Resection up to the alveolar ridge. Circumscribed here, with removal of the alveolar ridge mucosa, resection and removal of the posterior palatal arch. The muscles of the posterior palatal arch are also resected extensively if they are adherent. A muscle cuff can also be left on the tumor laterally. However, the tumor extends into the soft tissues of the neck. Overall, complete tumor removal transorally. The specimen also shows an in sano resection, so that the specimen is thread-marked for frozen section diagnostics. All mucosal margins as well as the basal margins are free of tumor and dysplasia, so that an R0 situation can be assumed here. Turning to the neck dissection of the right side: Here, the perforated skin area is cut around in a spindle shape. Release of the skin. Subcutaneous, extensive inflammatory surrounding of the metastasis is also seen later, so that the skin resection must be extended here, with no clear distinction between tumor and inflammatory events. Widen the skin incision caudally. Exposure of the sternocleidomastoid muscle cranially on the mastoid and caudally. Widespread infiltration of the muscle. It is therefore cut at its insertion and origins. Visualization of the omohyoid muscle. Clearly inflammatory scarring in the direction of the submandibular gland. However, this is not infiltrated. Release of the capsule. Exposure of the digastric muscle. This is also resected if adherent to the metastasis. Infiltration and consumption of the accessorius nerve. This is not exposed. The internal jugular vein, vagus nerve and common carotid artery are visualized caudally. At the level of the metastatic conglomerate, the vein is infiltrated and thrombosed cranially. For this reason, the vein is removed caudally. Preservation of the common carotid artery and the hypoglossal nerve. Separation of the occipital and facial arteries. Partial resection of the cervical plexus. No further metastasis in the direction of level Vb. Overall, however, complete resection of the right cervical draining veins due to the extent of the tumor. Resection of the metastatic conglomerate and the attached neck preparation in toto. After removal, there is now a defect measuring approx. 3 cm to the primary tumor region. Therefore, blunt opening is performed here with a clear indication for defect reconstruction due to the pharyngocutaneous fistula. Due to the resected superficial and deep veins on the right side, there is no possibility of a microvascular connection here. Therefore, the indication is for defect coverage using a pedicled supraclavicular island flap. If there is good skin mobility here, the defect is measured. An area measuring 8x5 cm is then incised in a spindle shape. Resection down to the muscle fascia. Removal of the muscle fascia. Release of the tissue at the acromion and isolation of the supplying vascular area from the transversa colli artery, which could already be identified by Doppler sonography before lifting the flap. Release on all sides of the trapezius muscle at the clavicle, so that a well mobile pedicle can be developed overall, with completely tension-free insertion into the oral cavity. Prior to this, the skin incision was widened and the skin dissected. Insertion of the flap into the oral cavity and successive suturing. Subsequently, tight conditions on all sides with a vital flap and overall sufficient reconstruction. The wound is then irrigated on the right cervical side. If the wound is dry, insertion of two 10-gauge Redon drains. Careful two-layer wound closure. Neck dissection of the left side was performed at the same time as defect reconstruction: skin incision on the anterior edge of the sternocleidomastoid muscle. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digastric muscle. Clearing of levels II to Va and preservation of the facial vein, superior thyroid artery, accessorius nerve, hypoglossal nerve and cervical plexus branches. Exposure and preservation of the vagus nerve and common carotid artery. Overall, no macroscopically highly visible nodes. Subsequent wound irrigation and inspection. If the wound is dry, insertion of a 10-gauge Redon drain. Careful two-layer wound closure. Due to the extent of the procedure, a final protective tracheotomy is performed: incision at the level of the cricoid cartilage. Skin incision. Cut through skin and subcutaneous tissue. Exposure of the cricoid cartilage and the anterior surface of the trachea, after separation of the infrahyoid muscles. Exposure and transection of the thyroid isthmus. Entering the trachea. Widening by performing a visor tracheostomy and then successive incision of the tracheostoma. Subsequent easy transfer to a size 8 low-cuff cannula, which is suture-fixed. Subsequent enoral inspection and, if the graft was vital, completion of the procedure without any indication of complications. The patient received intraoperative intravenous antibiotics with Unacid 3 g. Please continue this for 24 hours postoperatively. Conclusion: Intraoperative R0-resected cT2 cN2b-cN3 oropharyngeal carcinoma on the right. Please feed via the PEG tube for 7 days. Subsequently, with regular enoral healing and flap perfusion, gradual diet build-up. This should be functionally possible. Subsequently, prompt recanalization should be possible. \ No newline at end of file diff --git a/690/InvasionFront_CD3_block18_x3_y10_patient690_0.json b/690/InvasionFront_CD3_block18_x3_y10_patient690_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fe94afb93098ec6f5963176d8ce94747cdb6fca7 --- /dev/null +++ b/690/InvasionFront_CD3_block18_x3_y10_patient690_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10669.4, + "Centroid Y µm": 29709.3, + "Num Detections": 20022, + "Num Negative": 18335, + "Num Positive": 1687, + "Positive %": 8.426, + "Num Positive per mm^2": 806.73 + } +} \ No newline at end of file diff --git a/690/InvasionFront_CD3_block18_x4_y10_patient690_1.json b/690/InvasionFront_CD3_block18_x4_y10_patient690_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9520bb758ad90ae6b58a51a8abdc3aff43b6cc10 --- /dev/null +++ b/690/InvasionFront_CD3_block18_x4_y10_patient690_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 29859.2, + "Num Detections": 21078, + "Num Negative": 20032, + "Num Positive": 1046, + "Positive %": 4.963, + "Num Positive per mm^2": 498.08 + } +} \ No newline at end of file diff --git a/690/InvasionFront_CD8_block18_x3_y10_patient690_0.json b/690/InvasionFront_CD8_block18_x3_y10_patient690_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1261e1af180c6b511f9f7d4585a46069b38a7a61 --- /dev/null +++ b/690/InvasionFront_CD8_block18_x3_y10_patient690_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11294.0, + "Centroid Y µm": 32382.9, + "Num Detections": 23435, + "Num Negative": 22040, + "Num Positive": 1395, + "Positive %": 5.953, + "Num Positive per mm^2": 580.62 + } +} \ No newline at end of file diff --git a/690/InvasionFront_CD8_block18_x4_y10_patient690_1.json b/690/InvasionFront_CD8_block18_x4_y10_patient690_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a86ad74f332a2cb17ced720975cca01cd26d1749 --- /dev/null +++ b/690/InvasionFront_CD8_block18_x4_y10_patient690_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 32407.8, + "Num Detections": 24701, + "Num Negative": 24072, + "Num Positive": 629, + "Positive %": 2.546, + "Num Positive per mm^2": 262.62 + } +} \ No newline at end of file diff --git a/690/TumorCenter_CD3_block18_x3_y10_patient690_0.json b/690/TumorCenter_CD3_block18_x3_y10_patient690_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a3ff49d934b5594b20906a3076e52613580ff16c --- /dev/null +++ b/690/TumorCenter_CD3_block18_x3_y10_patient690_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10669.4, + "Centroid Y µm": 24224.7, + "Num Detections": 13060, + "Num Negative": 11616, + "Num Positive": 1444, + "Positive %": 11.06, + "Num Positive per mm^2": 650.99 + } +} \ No newline at end of file diff --git a/690/TumorCenter_CD3_block18_x4_y10_patient690_1.json b/690/TumorCenter_CD3_block18_x4_y10_patient690_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3805f71227161f54732e3938b5ab08f601ad4fa --- /dev/null +++ b/690/TumorCenter_CD3_block18_x4_y10_patient690_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13080.6, + "Centroid Y µm": 24255.9, + "Num Detections": 10624, + "Num Negative": 9658, + "Num Positive": 966, + "Positive %": 9.093, + "Num Positive per mm^2": 449.13 + } +} \ No newline at end of file diff --git a/690/TumorCenter_CD8_block18_x3_y10_patient690_0.json b/690/TumorCenter_CD8_block18_x3_y10_patient690_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5bf624d966632c94f381ba116703832acf1daa53 --- /dev/null +++ b/690/TumorCenter_CD8_block18_x3_y10_patient690_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10569.4, + "Centroid Y µm": 25136.7, + "Num Detections": 21365, + "Num Negative": 20194, + "Num Positive": 1171, + "Positive %": 5.481, + "Num Positive per mm^2": 503.27 + } +} \ No newline at end of file diff --git a/690/TumorCenter_CD8_block18_x4_y10_patient690_1.json b/690/TumorCenter_CD8_block18_x4_y10_patient690_1.json new file mode 100644 index 0000000000000000000000000000000000000000..948d0dd3bf6e52903d5eb25f8cddabaf7da66b03 --- /dev/null +++ b/690/TumorCenter_CD8_block18_x4_y10_patient690_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13118.1, + "Centroid Y µm": 25211.7, + "Num Detections": 21356, + "Num Negative": 20218, + "Num Positive": 1138, + "Positive %": 5.329, + "Num Positive per mm^2": 496.32 + } +} \ No newline at end of file diff --git a/690/history_text.txt b/690/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..877c193191eff1f8c4fc5aad106f43364b1cf173 --- /dev/null +++ b/690/history_text.txt @@ -0,0 +1 @@ +After an external partial laryngectomy, the patient showed a suprastomal hematoma on the right and left side, therefore indication for hemostasis in ITN. \ No newline at end of file diff --git a/690/icd_codes.txt b/690/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d608b19051054e4e431c530e7ce1798186204561 --- /dev/null +++ b/690/icd_codes.txt @@ -0,0 +1 @@ +Blutung und Hämatom als Komplikation während oder nach Eingriff[T81.0 ] \ No newline at end of file diff --git a/690/ops_codes.txt b/690/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..797b15ee84932b3d3c7a9376edcf1039d5b0f796 --- /dev/null +++ b/690/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Operation Larynx und Trachea[5-319.x ] \ No newline at end of file diff --git a/690/patient_clinical_data.json b/690/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b4ab3a45f86fd62f2283bbd9f92a51b38e5ea30c --- /dev/null +++ b/690/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 75, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/690/patient_pathological_data.json b/690/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cd96d22bb2901c036f0f34900618df020f74b965 --- /dev/null +++ b/690/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "690", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/690/surgery_description.txt b/690/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fd65d7b799714a674db66b860512ac1fcd633ff3 --- /dev/null +++ b/690/surgery_description.txt @@ -0,0 +1 @@ +Laryngeal partial resection, Tracheotomy diff --git a/690/surgery_report.txt b/690/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c839e0e7c6ab1f39c188f32d49304ae80ebff7b5 --- /dev/null +++ b/690/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues. After positioning the patient, the surgeon opens the skin and performs subcutaneous sutures. A bleeding vessel is found paramedian suprastomally on the right in the area of the musculature. This is coagulated bipolarly, followed by further careful hemostasis in the surrounding tissue. Wound closed again. Insertion of a flap. Dry conditions at the end of the operation. Insertion of a new cannula. Handover to anesthesia. End of surgery. \ No newline at end of file diff --git a/691/InvasionFront_CD3_block21_x5_y10_patient691_0.json b/691/InvasionFront_CD3_block21_x5_y10_patient691_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c15a147019b4b2384d5785c4e027a037c5520703 --- /dev/null +++ b/691/InvasionFront_CD3_block21_x5_y10_patient691_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18215.4, + "Centroid Y µm": 36030.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/691/InvasionFront_CD3_block21_x6_y10_patient691_1.json b/691/InvasionFront_CD3_block21_x6_y10_patient691_1.json new file mode 100644 index 0000000000000000000000000000000000000000..01371f540de6355edeb2542cea1df5665c94c9a8 --- /dev/null +++ b/691/InvasionFront_CD3_block21_x6_y10_patient691_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20664.1, + "Centroid Y µm": 36155.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/691/InvasionFront_CD8_block21_x5_y10_patient691_0.json b/691/InvasionFront_CD8_block21_x5_y10_patient691_0.json new file mode 100644 index 0000000000000000000000000000000000000000..58709e268343d7e6d39ca6668ea1d9962d1d7524 --- /dev/null +++ b/691/InvasionFront_CD8_block21_x5_y10_patient691_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 24562.0, + "Num Detections": 7841, + "Num Negative": 7598, + "Num Positive": 243, + "Positive %": 3.099, + "Num Positive per mm^2": 294.9 + } +} \ No newline at end of file diff --git a/691/InvasionFront_CD8_block21_x6_y10_patient691_1.json b/691/InvasionFront_CD8_block21_x6_y10_patient691_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4af039d05f08d6f85b8794851596bbaa24f99bda --- /dev/null +++ b/691/InvasionFront_CD8_block21_x6_y10_patient691_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 24562.0, + "Num Detections": 16149, + "Num Negative": 15726, + "Num Positive": 423, + "Positive %": 2.619, + "Num Positive per mm^2": 238.57 + } +} \ No newline at end of file diff --git a/691/TumorCenter_CD3_block21_x5_y10_patient691_0.json b/691/TumorCenter_CD3_block21_x5_y10_patient691_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9cb3e14ee1779f50d0b91cd8c4c15e75ea854238 --- /dev/null +++ b/691/TumorCenter_CD3_block21_x5_y10_patient691_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15932.1, + "Centroid Y µm": 27488.1, + "Num Detections": 7052, + "Num Negative": 6409, + "Num Positive": 643, + "Positive %": 9.118, + "Num Positive per mm^2": 734.7 + } +} \ No newline at end of file diff --git a/691/TumorCenter_CD3_block21_x6_y10_patient691_1.json b/691/TumorCenter_CD3_block21_x6_y10_patient691_1.json new file mode 100644 index 0000000000000000000000000000000000000000..41a50946e32e6dea509e1072a0d41f85834171e4 --- /dev/null +++ b/691/TumorCenter_CD3_block21_x6_y10_patient691_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18377.8, + "Centroid Y µm": 27487.1, + "Num Detections": 12362, + "Num Negative": 12054, + "Num Positive": 308, + "Positive %": 2.492, + "Num Positive per mm^2": 220.23 + } +} \ No newline at end of file diff --git a/691/TumorCenter_CD8_block21_x5_y10_patient691_0.json b/691/TumorCenter_CD8_block21_x5_y10_patient691_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14b640af3c8dac9caefecd6eed27a9dacec8c308 --- /dev/null +++ b/691/TumorCenter_CD8_block21_x5_y10_patient691_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17840.6, + "Centroid Y µm": 40003.8, + "Num Detections": 16577, + "Num Negative": 15816, + "Num Positive": 761, + "Positive %": 4.591, + "Num Positive per mm^2": 403.15 + } +} \ No newline at end of file diff --git a/691/TumorCenter_CD8_block21_x6_y10_patient691_1.json b/691/TumorCenter_CD8_block21_x6_y10_patient691_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e998c9c68b60e6c63dde143bc8e13d847f33fe2a --- /dev/null +++ b/691/TumorCenter_CD8_block21_x6_y10_patient691_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20264.3, + "Centroid Y µm": 40103.8, + "Num Detections": 12481, + "Num Negative": 11903, + "Num Positive": 578, + "Positive %": 4.631, + "Num Positive per mm^2": 390.92 + } +} \ No newline at end of file diff --git a/691/history_text.txt b/691/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..00b8484d6a1e6fbc8beb45c1c24aea8e83357ee4 --- /dev/null +++ b/691/history_text.txt @@ -0,0 +1 @@ +The patient has a biopsy-confirmed cT1b laryngeal carcinoma. Therefore, the above-mentioned procedure was performed. \ No newline at end of file diff --git a/691/icd_codes.txt b/691/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc6fd121dc40d22b6fb46d31a947332bc01b0c9d --- /dev/null +++ b/691/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/691/ops_codes.txt b/691/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..189628d044feb991b18dcc8b8a54a55c5bc19ebb --- /dev/null +++ b/691/ops_codes.txt @@ -0,0 +1 @@ +Andere partielle Laryngektomie: Teilresektion, frontolateral (Leroux-Robert)[5-302.7 ] \ No newline at end of file diff --git a/691/patient_clinical_data.json b/691/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5190499b31ced54bef59e10405ee34879e32bf64 --- /dev/null +++ b/691/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 66, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/691/patient_pathological_data.json b/691/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..52c6034316aed16fa7830ed3dfbdf202565df073 --- /dev/null +++ b/691/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "691", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/691/surgery_description.txt b/691/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1322c0d6cb7a38834ca4eb9d9f29abe56f1bbb3 --- /dev/null +++ b/691/surgery_description.txt @@ -0,0 +1 @@ +Frontolateral partial resection of larynx diff --git a/691/surgery_report.txt b/691/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f91a0ac0b4449d58cc89d9e36c4573df9e1c7842 --- /dev/null +++ b/691/surgery_report.txt @@ -0,0 +1 @@ +First, after alcohol disinfection, local anesthesia is applied. Skin incision. Subcutaneous preparation in depth. Median splitting of the infrahyoid musculature. Exposure of the thyroid cartilage. Push the perichondrium from the left side over to the right. Then left paramedian splitting of the thyroid cartilage. Entering the larynx. Starting from the supraglottic side, the left vocal fold is first completely incised, also towards the subglottic side and partially released. The thyroid cartilage is then also cut through on the right, so that a V-shaped section of thyroid cartilage remains on the complete resection. Here too, the soft tissue is pushed away from the inner wall of the thyroid cartilage. The tumor is then cut around successively, starting from the supraglottic area; the left tumor was only in the area of the left vocal fold, approximately up to the middle third. On the right side, the vocal fold tumor on the vocal fold extends to just before the vocal process; it also extends slightly into the morgue sinus and is completely cut around here. The specimen is thread-marked for final histology with a short/short thread mark for the vocal fold at the right rear and a long/long thread mark for the subglottic anterior commissure. Subsequent resections are then successively made in the supraglottic region and in the morgue sinus on the right and left. These are also sent for final histology. Circular margin samples are then taken. These are all tumor-free, with only minor dysplasia in the right supraglottic region, which is not resected further. Finally, careful hemostasis. Insertion of a Keel. Multi-layer wound closure and insertion of a flap. Completion of the procedure. \ No newline at end of file diff --git a/692/InvasionFront_CD3_block7_x3_y10_patient692_0.json b/692/InvasionFront_CD3_block7_x3_y10_patient692_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cbd5bce17b9a48983e4bb1967f54e5c6d02d0357 --- /dev/null +++ b/692/InvasionFront_CD3_block7_x3_y10_patient692_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11444.9, + "Centroid Y µm": 24461.6, + "Num Detections": 26810, + "Num Negative": 26156, + "Num Positive": 654, + "Positive %": 2.439, + "Num Positive per mm^2": 250.79 + } +} \ No newline at end of file diff --git a/692/InvasionFront_CD3_block7_x4_y10_patient692_1.json b/692/InvasionFront_CD3_block7_x4_y10_patient692_1.json new file mode 100644 index 0000000000000000000000000000000000000000..af99e96ef73c6f64fac0b26f7ea8348808d74bcf --- /dev/null +++ b/692/InvasionFront_CD3_block7_x4_y10_patient692_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14030.1, + "Centroid Y µm": 24337.1, + "Num Detections": 13534, + "Num Negative": 13068, + "Num Positive": 466, + "Positive %": 3.443, + "Num Positive per mm^2": 289.14 + } +} \ No newline at end of file diff --git a/692/InvasionFront_CD8_block7_x3_y10_patient692_0.json b/692/InvasionFront_CD8_block7_x3_y10_patient692_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7fb37924a976dbf08a7b105e8ddb6576d5caff8f --- /dev/null +++ b/692/InvasionFront_CD8_block7_x3_y10_patient692_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 25386.6, + "Num Detections": 23657, + "Num Negative": 22736, + "Num Positive": 921, + "Positive %": 3.893, + "Num Positive per mm^2": 358.92 + } +} \ No newline at end of file diff --git a/692/InvasionFront_CD8_block7_x4_y10_patient692_1.json b/692/InvasionFront_CD8_block7_x4_y10_patient692_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3fbfd496485d62557287dc9895e64f07f1ae8543 --- /dev/null +++ b/692/InvasionFront_CD8_block7_x4_y10_patient692_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 25661.4, + "Num Detections": 10881, + "Num Negative": 10371, + "Num Positive": 510, + "Positive %": 4.687, + "Num Positive per mm^2": 316.42 + } +} \ No newline at end of file diff --git a/692/TumorCenter_CD3_block7_x3_y10_patient692_0.json b/692/TumorCenter_CD3_block7_x3_y10_patient692_0.json new file mode 100644 index 0000000000000000000000000000000000000000..67e551eee04b7f1cde925acb43d0dea0186038a3 --- /dev/null +++ b/692/TumorCenter_CD3_block7_x3_y10_patient692_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10744.3, + "Centroid Y µm": 25361.6, + "Num Detections": 25393, + "Num Negative": 21748, + "Num Positive": 3645, + "Positive %": 14.35, + "Num Positive per mm^2": 1392.1 + } +} \ No newline at end of file diff --git a/692/TumorCenter_CD3_block7_x4_y10_patient692_1.json b/692/TumorCenter_CD3_block7_x4_y10_patient692_1.json new file mode 100644 index 0000000000000000000000000000000000000000..06ee1aab6832b6f7a9452d9eed8e4c93f56e00d3 --- /dev/null +++ b/692/TumorCenter_CD3_block7_x4_y10_patient692_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13317.9, + "Centroid Y µm": 25336.6, + "Num Detections": 24689, + "Num Negative": 21354, + "Num Positive": 3335, + "Positive %": 13.51, + "Num Positive per mm^2": 1274.0 + } +} \ No newline at end of file diff --git a/692/TumorCenter_CD8_block7_x3_y10_patient692_0.json b/692/TumorCenter_CD8_block7_x3_y10_patient692_0.json new file mode 100644 index 0000000000000000000000000000000000000000..771100d28d922a828cc0d0d10ab166b36ece0b13 --- /dev/null +++ b/692/TumorCenter_CD8_block7_x3_y10_patient692_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10544.4, + "Centroid Y µm": 25111.7, + "Num Detections": 26755, + "Num Negative": 24458, + "Num Positive": 2297, + "Positive %": 8.585, + "Num Positive per mm^2": 878.39 + } +} \ No newline at end of file diff --git a/692/TumorCenter_CD8_block7_x4_y10_patient692_1.json b/692/TumorCenter_CD8_block7_x4_y10_patient692_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fc3f50aafc8f092339778959ba0efc72e9ac5442 --- /dev/null +++ b/692/TumorCenter_CD8_block7_x4_y10_patient692_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13093.1, + "Centroid Y µm": 25111.7, + "Num Detections": 27000, + "Num Negative": 24897, + "Num Positive": 2103, + "Positive %": 7.789, + "Num Positive per mm^2": 806.46 + } +} \ No newline at end of file diff --git a/692/history_text.txt b/692/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9aa61edb424b4831d17ce3e2a6ebd9e80ec4cb02 --- /dev/null +++ b/692/history_text.txt @@ -0,0 +1 @@ +The patient has an unclear mass on the right side of the neck with no definite evidence of a tumor in previously taken samples. A PET-CT was then performed. The right base of the tongue as well as the mass on the right side of the neck were illuminated. The above-mentioned procedure was therefore performed. \ No newline at end of file diff --git a/692/icd_codes.txt b/692/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d7c618b24c2c5c562714d7c8b523aeba6e35366 --- /dev/null +++ b/692/icd_codes.txt @@ -0,0 +1 @@ +Oropharynxkarzinom[C10.9 ] Zervikale Lymphknotenmetastase[C77.0 ] \ No newline at end of file diff --git a/692/ops_codes.txt b/692/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e52179821d6329d27a8c940c756f202c109f474d --- /dev/null +++ b/692/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Diagnostische Tracheoskopie [über den Larynx] onA[1-620.y ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 R] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/692/patient_clinical_data.json b/692/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..11b67677e9aca231a7e7a8201a2e1846aa2ed8a1 --- /dev/null +++ b/692/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/692/patient_pathological_data.json b/692/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2cb8afeac083e370302e7a8a9f8ac2b2dc8c885f --- /dev/null +++ b/692/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "692", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 12, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/692/surgery_description.txt b/692/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4516430332076c98f5d48ca467f6c27896857c80 --- /dev/null +++ b/692/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Radial neck dissection on the right diff --git a/692/surgery_report.txt b/692/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3528ae1d1131a2d53f4c3ecfb4545cfb9547b871 --- /dev/null +++ b/692/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department to release the patient. Induction of anesthesia. Performance of tracheoscopy: inconspicuous conditions in the endolarynx up to the bifurcation. Careful inspection of the larynx with microlaryngoendoscopy as well as the hypopharynx and base of the tongue: An ulcerated area is then found here. This is biopsied and found to be a carcinoma in situ invasive carcinoma in a frozen section. Therefore, complete performance of the above-mentioned procedure. To do this, first position the tumor with the spreading laryngoscope, then cut around the tumor with the 8 W CO2 laser. The tumor can be sent as a complete specimen for histology. Positive marginal samples with a CIS in the middle of the tongue base and caudal or caudal right. For this reason, at the end of the operation, a resection is taken from the middle of the base of the tongue and a marginal sample is taken. The same is done on the caudal right section. A resection with a final marginal sample is also taken here. Additional resection in the area of the wound base, as the tumor is relatively close to the edges of the wound according to the frozen section. If the mucosal margins in these areas are completely inconspicuous on inspection, these samples are sent for final histology. The tumor at the base of the tongue is generally difficult to control, which is why surgical conditions are also difficult here. In the meantime, radical neck dissection is performed on the right side: skin incision for this. Subcutaneous dissection in depth. Exposure of the sternocleidomastoid muscle. The mass infiltrating the muscle and the accessorius nerve can already be seen here. The digastric muscle is first exposed cranially. The internal jugular vein is shown caudally. This shows that it is probably infiltrated by this tumor, so that the decision is made to sacrifice the internal jugular vein. It is exposed caudally and cranially, ligated and sent for histology together with the radical neck preparation, taking the sternocleidomastoid muscle with it, after resection. Exposure of the accessory nerve and the external and internal carotid arteries. Exposure of the hypoglossal nerve and protection of the same. Displacement, neurolysis and re-embedding of the accessory and hypoglossal nerves. Development of the lateral neck preparation, as already described up to just below the omohyoid muscle. Development of the medial neck preparation, including the capsule of the submandibular gland in the caudal part. Overall, due to the extensive and large metastasis, the surgical conditions were considerably more difficult. Careful wound irrigation in the area of the neck preparation. Insertion of a Redon drain. Multi-layer wound closure. Skin suturing with Monocryl sutures. Application of a pressure bandage. Final inspection at the end, no bleeding. Final consultation with the anesthetist. Completion of the procedure. Note: Diagnosis: cT2 cN3 oropharyngeal carcinoma on the right. \ No newline at end of file diff --git a/693/InvasionFront_CD3_block21_x3_y12_patient693_0.json b/693/InvasionFront_CD3_block21_x3_y12_patient693_0.json new file mode 100644 index 0000000000000000000000000000000000000000..742eb6a0eb8e29a25a579c2d2b46d7600823acbc --- /dev/null +++ b/693/InvasionFront_CD3_block21_x3_y12_patient693_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12243.5, + "Centroid Y µm": 40678.5, + "Num Detections": 19747, + "Num Negative": 17881, + "Num Positive": 1866, + "Positive %": 9.45, + "Num Positive per mm^2": 782.8 + } +} \ No newline at end of file diff --git a/693/InvasionFront_CD3_block21_x4_y12_patient693_1.json b/693/InvasionFront_CD3_block21_x4_y12_patient693_1.json new file mode 100644 index 0000000000000000000000000000000000000000..745f2990f5d86855e352d58adb1efa8b6ba8da01 --- /dev/null +++ b/693/InvasionFront_CD3_block21_x4_y12_patient693_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14992.1, + "Centroid Y µm": 41178.2, + "Num Detections": 11926, + "Num Negative": 11473, + "Num Positive": 453, + "Positive %": 3.798, + "Num Positive per mm^2": 285.5 + } +} \ No newline at end of file diff --git a/693/InvasionFront_CD8_block21_x3_y12_patient693_0.json b/693/InvasionFront_CD8_block21_x3_y12_patient693_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3bdbf552bca7fc77288959ab52ccb09e32cc9971 --- /dev/null +++ b/693/InvasionFront_CD8_block21_x3_y12_patient693_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 29484.4, + "Num Detections": 22057, + "Num Negative": 20530, + "Num Positive": 1527, + "Positive %": 6.923, + "Num Positive per mm^2": 586.48 + } +} \ No newline at end of file diff --git a/693/InvasionFront_CD8_block21_x4_y12_patient693_1.json b/693/InvasionFront_CD8_block21_x4_y12_patient693_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4f52d7eb151c72fff2f12d4871182ede57f619cb --- /dev/null +++ b/693/InvasionFront_CD8_block21_x4_y12_patient693_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 29459.4, + "Num Detections": 13542, + "Num Negative": 13017, + "Num Positive": 525, + "Positive %": 3.877, + "Num Positive per mm^2": 268.78 + } +} \ No newline at end of file diff --git a/693/TumorCenter_CD8_block21_x3_y12_patient693_0.json b/693/TumorCenter_CD8_block21_x3_y12_patient693_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dec3a4f2aadc7126f415dde52844877da7b4185a --- /dev/null +++ b/693/TumorCenter_CD8_block21_x3_y12_patient693_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12906.3, + "Centroid Y µm": 44531.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/693/TumorCenter_CD8_block21_x4_y12_patient693_1.json b/693/TumorCenter_CD8_block21_x4_y12_patient693_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ac32714acdd410e7ca2aed3439a6d92f7e814581 --- /dev/null +++ b/693/TumorCenter_CD8_block21_x4_y12_patient693_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15321.1, + "Centroid Y µm": 44638.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/693/history_text.txt b/693/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/693/icd_codes.txt b/693/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b2b94cb50933cfa2488a2941aa728866a25f7e3 --- /dev/null +++ b/693/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 ] \ No newline at end of file diff --git a/693/ops_codes.txt b/693/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..034a22f25e9c5f0967d63402101c57626f540dfc --- /dev/null +++ b/693/ops_codes.txt @@ -0,0 +1 @@ +Laserresektion Larynxgewebe mit Stützlaryngoskopie[5-302.5 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/693/patient_clinical_data.json b/693/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..237722edf186152e42afb561bd1a7c97f31bf40a --- /dev/null +++ b/693/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 7, + "adjuvant_treatment_intent": "palliative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/693/patient_pathological_data.json b/693/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..79f1aab0c3f4b3341823f92923948d8f0f435f1d --- /dev/null +++ b/693/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "693", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/693/surgery_description.txt b/693/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a3a2b9c99c6a0e6d460a93e35769d608caa42ef --- /dev/null +++ b/693/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Tracheotomy, PEG placement, Bilateral neck dissection (5 Levels) diff --git a/693/surgery_report.txt b/693/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..226dd0e4feb9211eb64f4a604daebcb437f2cf25 --- /dev/null +++ b/693/surgery_report.txt @@ -0,0 +1 @@ +After intubation anesthesia, initially extremely difficult adjustment of the epiglottis with the size B small bore tube. The tumor is then resected together with the base of the tongue and the entire epiglottis using support autoscopy and the CO2 laser, with repeated and extremely laborious repositioning of the small water tube. During dissection, the most careful hemostasis is always performed in the event of diffuse bleeding. The tumor is then removed together with the epiglottis, initially above the anterior commissure. Here, further resections are performed in the area of the lower left, lower right and lower front margins. The same marginal samples are then taken and sent for frozen section diagnostics. All marginal samples are found to be tumor-free by the pathology colleagues. After further careful hemostasis, the patient is repositioned, initially for tracheotomy: injection of local anesthetic with adrenaline and disinfection of the skin. Then door leaf incision and layer-by-layer dissection in depth. This reveals an extremely pronounced thyroid isthmus, which is cut on both sides and then lanced. Then expose the anterior surface of the trachea. Then insertion between the 2nd and 3rd cartilage clasp into the trachea. Then creation of the Björk flap and suturing of the flap. Then circular epithelialization of the tracheostoma. The patient is then intubated and receives a size 7 endotracheal tube. The patient is then repositioned for PEG insertion: the flexible instrument is inserted into the esophagus without difficulty. Then visual endoscopy into the stomach. If the diaphanoscopy is positive, the PEG is then placed in the typical position using the thread pull-through method. This is done without complications. After injection of local anesthetic with adrenaline and skin disinfection on both sides of the neck and repositioning of the patient, the operation is continued with neck dissection on both sides: Start on the right side first. To do this, make a skin incision along the front edge of the sternocleidomastoid muscle. Then dissect in depth in layers and expose the neck sheath. Then develop the lateral neck preparation while preserving the structures of the cervical vascular sheath and the accessorius nerve. Suspect enlarged lymph nodes are not revealed during dissection. Then clear the hypoglossal triangle while protecting the branches of the external carotid artery, the hypoglossal nerve and the branches of the facial vein. Then develop the anterior neck preparation while sparing the branches of the internal jugular vein. Problem-free dissection here too. Then most careful hemostasis and insertion of a Redon drainage. Multi-layer wound closure. Then identical procedure on the left side. Here, too, the dissection is carried out while protecting all structures of the cervical vascular sheath and the accessorius nerve. A paired arrangement of the internal jugular vein can be seen here. This divides cranially of the omohyoid muscle into a medial and a lateral branch. In the cranial course, the hypoglossal nerve crosses the two branches. This makes dissection extremely laborious and time-consuming. Ultimately, however, the dissections of the lateral neck and the hypoglossal triangle can be spared, while sparing the branches of the external carotid artery, facial vein and both branches of the internal jugular artery as well as the accessorius nerve. Then complete the neck dissection with the anterior neck preparation, sparing the branches of the medial internal jugular branch. The most careful hemostasis is then applied here too. Also insertion of a Redon drain and multi-layer wound closure. After dressing and insertion of a size 7 tracheostomy tube, the procedure is completed without complications. The patient is transferred to the in-house intensive care unit for monitoring. \ No newline at end of file diff --git a/694/InvasionFront_CD8_block20_x1_y12_patient694_0.json b/694/InvasionFront_CD8_block20_x1_y12_patient694_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e3004d6966b42989e1b4f2a4269b71f3e3579d1f --- /dev/null +++ b/694/InvasionFront_CD8_block20_x1_y12_patient694_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5297.2, + "Centroid Y µm": 29959.1, + "Num Detections": 13702, + "Num Negative": 12944, + "Num Positive": 758, + "Positive %": 5.532, + "Num Positive per mm^2": 421.79 + } +} \ No newline at end of file diff --git a/694/InvasionFront_CD8_block20_x2_y12_patient694_1.json b/694/InvasionFront_CD8_block20_x2_y12_patient694_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4392e0f97ac221c66bc08c09e822d2cdcc805095 --- /dev/null +++ b/694/InvasionFront_CD8_block20_x2_y12_patient694_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7745.9, + "Centroid Y µm": 29959.1, + "Num Detections": 14927, + "Num Negative": 14515, + "Num Positive": 412, + "Positive %": 2.76, + "Num Positive per mm^2": 201.54 + } +} \ No newline at end of file diff --git a/694/TumorCenter_CD3_block20_x1_y12_patient694_0.json b/694/TumorCenter_CD3_block20_x1_y12_patient694_0.json new file mode 100644 index 0000000000000000000000000000000000000000..97317c84d179b9b3d083b2e86bc1744422429b6e --- /dev/null +++ b/694/TumorCenter_CD3_block20_x1_y12_patient694_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3782.5, + "Centroid Y µm": 29193.4, + "Num Detections": 3454, + "Num Negative": 2939, + "Num Positive": 515, + "Positive %": 14.91, + "Num Positive per mm^2": 405.22 + } +} \ No newline at end of file diff --git a/694/TumorCenter_CD3_block20_x2_y12_patient694_1.json b/694/TumorCenter_CD3_block20_x2_y12_patient694_1.json new file mode 100644 index 0000000000000000000000000000000000000000..44b4086cf80f0a4f8d019f3b844a1a1141c4d60f --- /dev/null +++ b/694/TumorCenter_CD3_block20_x2_y12_patient694_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6380.4, + "Centroid Y µm": 28963.2, + "Num Detections": 4644, + "Num Negative": 3640, + "Num Positive": 1004, + "Positive %": 21.62, + "Num Positive per mm^2": 564.96 + } +} \ No newline at end of file diff --git a/694/TumorCenter_CD8_block20_x1_y12_patient694_0.json b/694/TumorCenter_CD8_block20_x1_y12_patient694_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2c82c6e0eb6927d57e6490dbf03c1c6b08bcf11e --- /dev/null +++ b/694/TumorCenter_CD8_block20_x1_y12_patient694_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4347.7, + "Centroid Y µm": 30358.9, + "Num Detections": 14413, + "Num Negative": 13717, + "Num Positive": 696, + "Positive %": 4.829, + "Num Positive per mm^2": 358.31 + } +} \ No newline at end of file diff --git a/694/TumorCenter_CD8_block20_x2_y12_patient694_1.json b/694/TumorCenter_CD8_block20_x2_y12_patient694_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4edfd243386d1423183599579a1eb729a601e5db --- /dev/null +++ b/694/TumorCenter_CD8_block20_x2_y12_patient694_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 30234.0, + "Num Detections": 13246, + "Num Negative": 11963, + "Num Positive": 1283, + "Positive %": 9.686, + "Num Positive per mm^2": 703.37 + } +} \ No newline at end of file diff --git a/694/history_text.txt b/694/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8e5e826afb2d6cf62c93d5a0cb4a656b4981a14d --- /dev/null +++ b/694/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma, supraglottic, glottic and subglottic. In CT scan, thyroid cartilage breakthrough anteriorly. Therefore above mentioned surgery for cT4a cN2c status. \ No newline at end of file diff --git a/694/icd_codes.txt b/694/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9c4257ca45cf006cb926b4881421850b7877df22 --- /dev/null +++ b/694/icd_codes.txt @@ -0,0 +1 @@ +Neubildung bösartig Kehlkopf sonstige[C32.8 ] \ No newline at end of file diff --git a/694/ops_codes.txt b/694/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2441ca5e3efe6dd95d41393b2de9be92380d154e --- /dev/null +++ b/694/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie ohne Rekonstruktion[5-303.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Myotomie Musculus constrictor pharyngis[5-290.x ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Exzision erkranktes Gewebe Schilddrüse[5-062.0 B] \ No newline at end of file diff --git a/694/patient_clinical_data.json b/694/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..125977b8ad12370c65f7e550eaaabab900dc367b --- /dev/null +++ b/694/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/694/patient_pathological_data.json b/694/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fe7bf41af8e69c6f319d3d47d52e2759938dd836 --- /dev/null +++ b/694/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "694", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 30.0 +} \ No newline at end of file diff --git a/694/surgery_description.txt b/694/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3be436ffc30edcb5ffd6cb6bb5fc69dcaf177343 --- /dev/null +++ b/694/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection diff --git a/694/surgery_report.txt b/694/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d39f327d331147a90e2706a499ca19778c0f88d1 --- /dev/null +++ b/694/surgery_report.txt @@ -0,0 +1 @@ +First, pharynxcopy and larynxcopy again: Confirmation of supraglottic to subglottic spread, tumor extends broadly forward into the anterior commissure. In CT, thyroid nodule rupture can be traced. Therefore, sterile draping after skin disinfection. Subsequent marking of an apron flap. This is lifted subplatysmally in a typical manner up to the level of the hyoid bone and submandibular gland. Then first modified radical neck dissection on the right: Dissection of the fat-lymph node packet from the sternocleidomastoid muscle. Then exposure of the cervical vascular sheath, internal jugular vein, internal/external carotid artery, vagus nerve, hypoglossal nerve and accessorius nerve. Several adherent lymph nodes cranial to the facial vein, clinically clearly suspicious. The facial vein is interrupted at the internal jugular vein. Nodes can be dissected from the internal jugular vein. Level II to V evacuation follows. Branches of the cervical plexus are preserved. Subsequently modified radical neck dissection on the left side: This is performed in the same way as on the right side with level II to V evacuation. Nodes are also clearly clinically positive cranially in level II as on the opposite side. They are not too adherent to the veins, which can be better preserved in this way. Subsequent laryngectomy: Skeletonization of the larynx in the same way on both sides. First, level VI lymph node preparation is removed and sent in separately. The infrahyoid muscles are then removed from the hyoid bone. This is cut downwards. This reveals a tumor breakthrough through the anterior commissure. Infrahyoid musculature is separated and the tumor is sent in as a frozen section marked with sutures. No tumor infiltrates towards the tumor-free side. Then release of the larynx, exposure of the superior chorda and dissection of the constrictor muscles on both sides. Outgoing vessels are ligated or bipolarly treated. Supraglottic soft tissues are completely removed up to the pharynx, below the hyoid bone. This is resected laterally on both sides. Due to the wide opening in the anterior region, the thyroid gland is partially resected on both sides, in the upper pole area. Several nodes are resected on the left side. The thyroid gland is repositioned by means of multiple re-stitching. The trachea is exposed, opened in the second intercartilaginous space with the incision directed cranially. Partial epithelialization of the trachea. Re-intubation, placement of a laryngectomy tube. Then opening of the larynx cranially, at the level of the epiglottis. Then release the larynx, leaving a distance of at least 1.5 cm to the tumor on all sides. Removal of the specimen. The larynx is marked with sutures and sent in as a frozen section. Complete removal of the tumor, cranially, caudally and basally. In conjunction with the previous marginal specimen, R0 situation. Subsequently, extensive irrigation of the wound area with H2O2 and Ringer's solution, careful hemostasis. The median myotomy is performed with the least possible mobilization of the soft tissue between the trachea or oesophagus, over approx. 3 to 3.5 cm. Subsequently insertion of an 8 mm Provox prosthesis in the typical manner, without complications. The medial part of the sternocleidomastoid muscle is detached close to the clavicle on both sides. The first suture is then used as an inverting suture to close the pharynx. A second inverting suture is placed over this, also with 3-0 Vicryl single button sutures. The constrictor muscles are sutured over this with 3-0 single button sutures and the suture is placed on top of the remaining hyoid bone. Careful hemostasis is then performed again. Irrigation with H2O2 and Ringer's solution. Wound closure in layers with insertion of a Redon drain in both sides of the neck. Epithelialization of the tracheostoma. Insertion of a 10 mm tracheal cannula. Conclusion without complications. Completion of the procedure without complications. Patient received Unacid 3 g intraoperatively. Please continue this antibiotic treatment for 2 days. Feeding via the previously inserted PEG tube until the 10th postoperative day, then gruel and, if necessary, a diet. Total cT4a cN2c transglottic laryngeal carcinoma. Radiochemotherapy should be discussed postoperatively. \ No newline at end of file diff --git a/695/InvasionFront_CD3_block5_x1_y10_patient695_0.json b/695/InvasionFront_CD3_block5_x1_y10_patient695_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d15e110451a195132ea5f616cf70921b1b05077 --- /dev/null +++ b/695/InvasionFront_CD3_block5_x1_y10_patient695_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3797.2, + "Centroid Y µm": 25512.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/695/InvasionFront_CD3_block5_x2_y10_patient695_1.json b/695/InvasionFront_CD3_block5_x2_y10_patient695_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1077a1dd7201a0057c15ace9b828f59e07ad8ab0 --- /dev/null +++ b/695/InvasionFront_CD3_block5_x2_y10_patient695_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6453.1, + "Centroid Y µm": 25584.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/695/InvasionFront_CD8_block5_x1_y8_patient695_0.json b/695/InvasionFront_CD8_block5_x1_y8_patient695_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3cf037a1fb911bcc906240746134858d0c13df76 --- /dev/null +++ b/695/InvasionFront_CD8_block5_x1_y8_patient695_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 20314.2, + "Num Detections": 15729, + "Num Negative": 15153, + "Num Positive": 576, + "Positive %": 3.662, + "Num Positive per mm^2": 279.38 + } +} \ No newline at end of file diff --git a/695/InvasionFront_CD8_block5_x2_y8_patient695_1.json b/695/InvasionFront_CD8_block5_x2_y8_patient695_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9f47deaedac9cbfe529f5046e119eadee6e3332f --- /dev/null +++ b/695/InvasionFront_CD8_block5_x2_y8_patient695_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 20114.3, + "Num Detections": 20014, + "Num Negative": 17619, + "Num Positive": 2395, + "Positive %": 11.97, + "Num Positive per mm^2": 1065.1 + } +} \ No newline at end of file diff --git a/695/TumorCenter_CD3_block5_x1_y8_patient695_0.json b/695/TumorCenter_CD3_block5_x1_y8_patient695_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e027df0b7d6ab22b4eb1eac8097a5ac5160c9708 --- /dev/null +++ b/695/TumorCenter_CD3_block5_x1_y8_patient695_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4197.8, + "Centroid Y µm": 19289.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/695/TumorCenter_CD3_block5_x2_y8_patient695_1.json b/695/TumorCenter_CD3_block5_x2_y8_patient695_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2258a11b5c41d8ce62052b895717838bfb349260 --- /dev/null +++ b/695/TumorCenter_CD3_block5_x2_y8_patient695_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6617.5, + "Centroid Y µm": 19450.5, + "Num Detections": 14363, + "Num Negative": 13044, + "Num Positive": 1319, + "Positive %": 9.183, + "Num Positive per mm^2": 704.81 + } +} \ No newline at end of file diff --git a/695/TumorCenter_CD8_block5_x1_y8_patient695_0.json b/695/TumorCenter_CD8_block5_x1_y8_patient695_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e083cdf0bd89461eeaf8e35a31d12806778e1eef --- /dev/null +++ b/695/TumorCenter_CD8_block5_x1_y8_patient695_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 20064.4, + "Num Detections": 18588, + "Num Negative": 18015, + "Num Positive": 573, + "Positive %": 3.083, + "Num Positive per mm^2": 252.38 + } +} \ No newline at end of file diff --git a/695/TumorCenter_CD8_block5_x2_y8_patient695_1.json b/695/TumorCenter_CD8_block5_x2_y8_patient695_1.json new file mode 100644 index 0000000000000000000000000000000000000000..29337000b0563d321286e7dd2de5d95bd0b08323 --- /dev/null +++ b/695/TumorCenter_CD8_block5_x2_y8_patient695_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 20089.4, + "Num Detections": 20482, + "Num Negative": 19185, + "Num Positive": 1297, + "Positive %": 6.332, + "Num Positive per mm^2": 559.51 + } +} \ No newline at end of file diff --git a/695/history_text.txt b/695/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/695/icd_codes.txt b/695/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8942df050249e3880166bd6eaf35efe4c40f2c9 --- /dev/null +++ b/695/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] \ No newline at end of file diff --git a/695/ops_codes.txt b/695/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d8cef022fd76f57bc7800d875477536036d88056 --- /dev/null +++ b/695/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Entnahme myokutaner Lappen mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.28 R] Einfache Laryngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.04 ] Sonstige radikale Resektion des Pharynx [Pharyngektomie][5-296.xx ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Permanente Tracheotomie[5-312.0 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] \ No newline at end of file diff --git a/695/patient_clinical_data.json b/695/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4613f0bcdfb77153ef40cc7af653a94fc7a8cb80 --- /dev/null +++ b/695/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 59, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/695/patient_pathological_data.json b/695/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..16cec0cefee7551ece82855dc33fa6a22edd1e0d --- /dev/null +++ b/695/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "695", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/695/surgery_description.txt b/695/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a28cdb1d0469784b15444fc928fd1f7a8a5397f6 --- /dev/null +++ b/695/surgery_description.txt @@ -0,0 +1 @@ +Partial pharyngectomy, LE, Neck dissection, Tracheotomy, Defect coverage (ALT flap) diff --git a/695/surgery_report.txt b/695/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..660d711c7e3cb01fa910786f0251ea345fe035ed --- /dev/null +++ b/695/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Performance of the tracheotomy by and . Horizontal skin incision, approx. 5 cm in length, along an old scar following thyroid surgery. Sharp cutting of the skin, subcutaneous tissue and parts of the platysma. Dissection in depth in the direction of the infrahyoid muscles. The infrahyoid musculature is exposed and cut in the midline. Cricoid cartilage is palpated. No residual thyroid tissue is visible. Only scarring between the musculature and the trachea. The scarred tissue below the musculature is removed with pointed scissors and bipolarized. Ultimately, the trachea is well exposed. The trachea is cut open between the 3rd and 4th tracheal clasp. Creation of a Björk flap with anticipated laryngectomy and reintubation of the patient. Lifting of the apron flap by and . Sharp transection of the skin, subcutaneous tissue, platysma and elevation of the skin-platysma flap in a typical manner to just above the hyoid bone. The submandibular gland is exposed on both sides and the apron flap is fixed using a chain dog. Neck dissection on the left: Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, the posterior belly of the digaster muscle, the left submandibular gland and the accessorius nerve. The cervical vascular sheath is shown. The anterior neck preparation is removed for the first time between the V. jugularis interna and V. facialis and M. omohyoideus. There are two large metastases on the internal jugular vein at level IIa. In order to gain an overview, the decision is made to remove level II b completely. This can also be done without any problems while sparing the accessorius nerve. Removal of levels III to V with protection of the plexus branches, after visualization of the vagus nerve, the internal carotid artery and the common carotid artery. Approach to level II further on the left side. Careful dissection of the two metastases from the jugular vein. Ultimately, the metastases can be removed without obstructing the jugular vein. Targeted hemostasis. This is a left neck dissection with complete evacuation of level II to V. In the case of macroscopic evidence of two metastases in level II a on the left side. Carry out the neck dissection on the right side. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, the posterior belly of the digaster muscle, the left submandibular gland and the accessorius nerve. The cervical vascular sheath is shown. The anterior neck preparation is removed for the first time between the internal jugular vein and facial vein and the omohyoid muscle. Level IIb is then removed above the accessorius nerve. Release of the lateral neck preparation while sparing the plexus branches and the hypoglossal nerve. The branches of the superior thyroid artery as well as the lingual and facial arteries are dissected for a possible anastomosis. Subtle hemostasis. Release of the larynx by . Detachment of the infrahyoid muscles for this purpose. Removal of the hyoid bone. Removal of the oblique laryngeal musculature and exposure of the thyroid cartilage on the right side. Then detachment of the piriform sinus on the right side. Exposure and detachment of the thyroid gland on both sides. On the left side, the piriform sinus cannot be detached due to infiltration of the thyroid cartilage. Enter with the McIVOR oral spatula and start with tumor resection at the lower tonsil pole with the monopolar needle and at the posterior palatal arch. The soft palate is also affected and must be partially resected. Then enter the pharynx from the neck. On the right side, disluxation of the epiglottis. Incision of the mucosa along the edge of the epiglottis up to the right arytenoid cartilage. It then becomes apparent that the tumor fills the entire piriform sinus, goes down to the esophageal entrance and infiltrates the medial wall and the thyroid cartilage. The tumor is cut around with a safety margin of 1.5 cm and the larynx is placed below the cricoid cartilage and marked with a suture. Unfortunately, the vocal folds could not be preserved for the laboratory as the larynx was accidentally placed in formalin by the nursing staff. Then marginal samples were taken. All marginal samples are tumor-free in the frozen section and free of carcinoma in situ. Measurement of the defect. The defect is 15 x 10 cm in size and extends from the tonsil region across the base of the tongue via the pharynx to the entrance to the esophagus. Decision to remove a transplant. The anterolateral thigh graft is suitable for this. Lifting of the anterolateral thigh graft by . To do this, draw a line between the lateral edge of the patella and the anterior superior iliac spine. Doppler the perforator vessels on this line. Five perforator vessels are identified and the graft is designed around the perforator vessels, 16 x 10 cm. Primary wound closure is still possible. Incision of the graft at the inferior medial edge. Expose and identify the rectus femoris muscle with its median fascia. Then identify the vastus lateralis muscle and enter the sulcus between these two muscles and identify the descending ramus of the circumflex femoral artery. The vastus lateralis is relatively thin, so that a delicate perforator graft is not lifted here and part of the vastus lateralis muscle is also lifted. Then set down. Then dissection of the pedicle and removal of the graft so that two veins remain, one large and one small. Undermining of the skin. Insertion of two Redon drains and cutting of Burow triangles and multi-layer wound closure in the usual manner. The graft is flushed with heparin and handed over to , who then sutures the graft into the pharynx in two layers. The vascular anastomosis is performed between the facial vein and an outlet from the facial vein. The artery is connected to the common outlet of the facial and lingual arteries. There is very good graft perforation. The graft can be controlled transorally as it goes up into the tonsillar lobes. Two-layer wound closure after insertion of a flap and a Redon drainage. After the laryngectomy, a size 8 Provox-Vega prosthesis was inserted. The patient is ventilated in the intensive care unit and should be on antibiotics for at least 24 hours. Flap checks according to the usual schedule. Completion of the procedure without complications. \ No newline at end of file diff --git a/696/InvasionFront_CD3_block17_x1_y4_patient696_0.json b/696/InvasionFront_CD3_block17_x1_y4_patient696_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3daa599d5fe2a23d2b712f0b7298f25370febc34 --- /dev/null +++ b/696/InvasionFront_CD3_block17_x1_y4_patient696_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 14867.1, + "Num Detections": 23542, + "Num Negative": 20885, + "Num Positive": 2657, + "Positive %": 11.29, + "Num Positive per mm^2": 1045.7 + } +} \ No newline at end of file diff --git a/696/InvasionFront_CD3_block17_x2_y4_patient696_1.json b/696/InvasionFront_CD3_block17_x2_y4_patient696_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f2974b434d7f7356b85f44d616862af02f0145e9 --- /dev/null +++ b/696/InvasionFront_CD3_block17_x2_y4_patient696_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6446.6, + "Centroid Y µm": 14917.1, + "Num Detections": 21713, + "Num Negative": 21557, + "Num Positive": 156, + "Positive %": 0.7185, + "Num Positive per mm^2": 68.42 + } +} \ No newline at end of file diff --git a/696/InvasionFront_CD8_block17_x1_y4_patient696_0.json b/696/InvasionFront_CD8_block17_x1_y4_patient696_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d04df8b98b868b4ae2037a64abea6e5a36786479 --- /dev/null +++ b/696/InvasionFront_CD8_block17_x1_y4_patient696_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3947.9, + "Centroid Y µm": 10244.6, + "Num Detections": 22359, + "Num Negative": 20275, + "Num Positive": 2084, + "Positive %": 9.321, + "Num Positive per mm^2": 874.34 + } +} \ No newline at end of file diff --git a/696/InvasionFront_CD8_block17_x2_y4_patient696_1.json b/696/InvasionFront_CD8_block17_x2_y4_patient696_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1b0da43b3b3412de5bb9c8ea932bc2e9e871daf6 --- /dev/null +++ b/696/InvasionFront_CD8_block17_x2_y4_patient696_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 10244.6, + "Num Detections": 20352, + "Num Negative": 20257, + "Num Positive": 95, + "Positive %": 0.4668, + "Num Positive per mm^2": 43.19 + } +} \ No newline at end of file diff --git a/696/TumorCenter_CD3_block17_x1_y4_patient696_0.json b/696/TumorCenter_CD3_block17_x1_y4_patient696_0.json new file mode 100644 index 0000000000000000000000000000000000000000..219a0254a79459695a31686552a892d8c3038eea --- /dev/null +++ b/696/TumorCenter_CD3_block17_x1_y4_patient696_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3748.0, + "Centroid Y µm": 9819.8, + "Num Detections": 14442, + "Num Negative": 14425, + "Num Positive": 17, + "Positive %": 0.1177, + "Num Positive per mm^2": 10.06 + } +} \ No newline at end of file diff --git a/696/TumorCenter_CD3_block17_x2_y4_patient696_1.json b/696/TumorCenter_CD3_block17_x2_y4_patient696_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3de97fc9cce62cc9f3b8c32da81f25a58010f872 --- /dev/null +++ b/696/TumorCenter_CD3_block17_x2_y4_patient696_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6171.7, + "Centroid Y µm": 9894.8, + "Num Detections": 19690, + "Num Negative": 17192, + "Num Positive": 2498, + "Positive %": 12.69, + "Num Positive per mm^2": 1078.7 + } +} \ No newline at end of file diff --git a/696/TumorCenter_CD8_block17_x1_y4_patient696_0.json b/696/TumorCenter_CD8_block17_x1_y4_patient696_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b249e38573d7eca62a9144689b3f76ca709f8e3b --- /dev/null +++ b/696/TumorCenter_CD8_block17_x1_y4_patient696_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6345.1, + "Centroid Y µm": 23756.5, + "Num Detections": 13984, + "Num Negative": 13974, + "Num Positive": 10, + "Positive %": 0.0715, + "Num Positive per mm^2": 5.701 + } +} \ No newline at end of file diff --git a/696/TumorCenter_CD8_block17_x2_y4_patient696_1.json b/696/TumorCenter_CD8_block17_x2_y4_patient696_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69c067c9bc06d48b4c55304c6621510f1eeddf88 --- /dev/null +++ b/696/TumorCenter_CD8_block17_x2_y4_patient696_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8970.3, + "Centroid Y µm": 23712.4, + "Num Detections": 20960, + "Num Negative": 17279, + "Num Positive": 3681, + "Positive %": 17.56, + "Num Positive per mm^2": 1592.4 + } +} \ No newline at end of file diff --git a/696/history_text.txt b/696/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d859d6d02ea5d8bb276ee8eff2eeee2408eead7 --- /dev/null +++ b/696/history_text.txt @@ -0,0 +1 @@ +The patient has a condition following panendoscopically confirmed glottic laryngeal carcinoma on the left side. No infiltration of the arytenoid cartilage and the anterior commissure in the previous panendoscopy. No thyroid cartilage invasion on CT. Preoperatively both vocal folds mobile. \ No newline at end of file diff --git a/696/icd_codes.txt b/696/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15cdf3cedbb267117d620058bfef3b6f5d6fd43f --- /dev/null +++ b/696/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/696/ops_codes.txt b/696/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f44140e87ecea1b9f38caa6758d00b81b13c70d4 --- /dev/null +++ b/696/ops_codes.txt @@ -0,0 +1 @@ +Endolaryngeale Chordektomie[5-302.1 ] Mikrolaryngoskopie mit Resektion eines Larynxtumors[5-300.2 ] \ No newline at end of file diff --git a/696/patient_clinical_data.json b/696/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4b60b5c8a816f443119dbe7861fcd222cb98e843 --- /dev/null +++ b/696/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/696/patient_pathological_data.json b/696/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5df93712c6194b76e2c93c24d6f8164a148b8e3d --- /dev/null +++ b/696/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "696", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/696/surgery_description.txt b/696/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..27972cb873c8748eb56c696838322a0edf409938 --- /dev/null +++ b/696/surgery_description.txt @@ -0,0 +1 @@ +Left laser chordectomy diff --git a/696/surgery_report.txt b/696/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..44cf5ba31ed55386a5c0c78d5a69f2deffffa3e8 --- /dev/null +++ b/696/surgery_report.txt @@ -0,0 +1 @@ +Transferring the patient to the operating room. Carrying out the team time-out and initial consultation with the anesthesia colleagues. Intubation anesthesia by the colleagues and fixation of the tube in the right corner of the mouth. Start of the operation by inserting the mouth guard. Entry with the Kleinsasser tube size D and adjustment of the endolarynx, after charging the epiglottis. The tumor is very easy to expose. The posterior commissure and the arytenoid hump are adjusted first. Cover the patient. Carry out the laser protection measures. Start splitting the tumor in the midline down to the muscles. Resection of the posterior part of the vocal folds with the resection margin just in front of the vocal process of the arytenoid cusp. Now removal of the tumor also after identification of the subglottic slope. No macroscopic tumor infiltration here. The posterior part of the tumor is completely removed. Now turn to the anterior commissure. No macroscopic infiltration here. Resection along the anterior commissure in a lateral direction up to the ligament and subglottically. The anterior part of the tumor is also removed here. Now obtain five marginal samples. Sending the marginal samples for frozen section pathological examination. This shows a margin-forming situation in the area of the tumor base. Also, according to the pathologists, a margin-forming tumor in the supraglottis area. Demonstration to and decision to carry out a resection using the microscope. A thick strip of muscle is removed in the area of the base of the tumor, as well as a strip of the pocket fold. Sending the resected specimens for final histopathological assessment and taking new marginal samples in the area of the tumor base, the pocket fold, the anterior commissure, the arytenoid hump and the subglottic slope. There was no further tumor infiltration in the area of the final margin samples, so that all findings together indicate an R0 resection. Subtle hemostasis using supratupfer without further bleeding. The operation was completed without complications. Summary: Laser-surgical cordectomy on the left side with removal of a T1 vocal fold carcinoma. Please wait for the final histopathological assessment. The frozen section shows an R0 resection. A follow-up MLE should be performed in 6 weeks. \ No newline at end of file diff --git a/697/InvasionFront_CD3_block17_x5_y9_patient697_0.json b/697/InvasionFront_CD3_block17_x5_y9_patient697_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6346e05cdaf99157d67ccfe93d8948d9de5bbb5 --- /dev/null +++ b/697/InvasionFront_CD3_block17_x5_y9_patient697_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 27885.2, + "Num Detections": 20133, + "Num Negative": 19690, + "Num Positive": 443, + "Positive %": 2.2, + "Num Positive per mm^2": 191.44 + } +} \ No newline at end of file diff --git a/697/InvasionFront_CD3_block17_x6_y9_patient697_1.json b/697/InvasionFront_CD3_block17_x6_y9_patient697_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e10b35909655d3468e888ef88ae152e9ac6423fc --- /dev/null +++ b/697/InvasionFront_CD3_block17_x6_y9_patient697_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18265.3, + "Centroid Y µm": 28085.1, + "Num Detections": 19783, + "Num Negative": 17929, + "Num Positive": 1854, + "Positive %": 9.372, + "Num Positive per mm^2": 843.61 + } +} \ No newline at end of file diff --git a/697/InvasionFront_CD8_block17_x5_y9_patient697_0.json b/697/InvasionFront_CD8_block17_x5_y9_patient697_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b52f8bbd5e071393f62c956824b6385a7519ce90 --- /dev/null +++ b/697/InvasionFront_CD8_block17_x5_y9_patient697_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16166.4, + "Centroid Y µm": 22738.0, + "Num Detections": 19079, + "Num Negative": 18641, + "Num Positive": 438, + "Positive %": 2.296, + "Num Positive per mm^2": 189.48 + } +} \ No newline at end of file diff --git a/697/InvasionFront_CD8_block17_x6_y9_patient697_1.json b/697/InvasionFront_CD8_block17_x6_y9_patient697_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e165f186cd1b25410bf8a132192e7bfea28b9afb --- /dev/null +++ b/697/InvasionFront_CD8_block17_x6_y9_patient697_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 22837.9, + "Num Detections": 18707, + "Num Negative": 16337, + "Num Positive": 2370, + "Positive %": 12.67, + "Num Positive per mm^2": 1093.4 + } +} \ No newline at end of file diff --git a/697/TumorCenter_CD3_block17_x5_y9_patient697_0.json b/697/TumorCenter_CD3_block17_x5_y9_patient697_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e9b8ea5e75a56e4b4c08f47608b0a2e153c145f7 --- /dev/null +++ b/697/TumorCenter_CD3_block17_x5_y9_patient697_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 22538.1, + "Num Detections": 20365, + "Num Negative": 19466, + "Num Positive": 899, + "Positive %": 4.414, + "Num Positive per mm^2": 393.11 + } +} \ No newline at end of file diff --git a/697/TumorCenter_CD3_block17_x6_y9_patient697_1.json b/697/TumorCenter_CD3_block17_x6_y9_patient697_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9509260e151d9d7f0d1998a14dd685c5688243d9 --- /dev/null +++ b/697/TumorCenter_CD3_block17_x6_y9_patient697_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 22638.0, + "Num Detections": 21023, + "Num Negative": 19981, + "Num Positive": 1042, + "Positive %": 4.956, + "Num Positive per mm^2": 444.88 + } +} \ No newline at end of file diff --git a/697/TumorCenter_CD8_block17_x5_y9_patient697_0.json b/697/TumorCenter_CD8_block17_x5_y9_patient697_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3d9e08696c8666f126a66296705e44627dc16594 --- /dev/null +++ b/697/TumorCenter_CD8_block17_x5_y9_patient697_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 36180.8, + "Num Detections": 19495, + "Num Negative": 19137, + "Num Positive": 358, + "Positive %": 1.836, + "Num Positive per mm^2": 167.0 + } +} \ No newline at end of file diff --git a/697/TumorCenter_CD8_block17_x6_y9_patient697_1.json b/697/TumorCenter_CD8_block17_x6_y9_patient697_1.json new file mode 100644 index 0000000000000000000000000000000000000000..494a4c392d22788ccfdc5475a7829b6fff504c2a --- /dev/null +++ b/697/TumorCenter_CD8_block17_x6_y9_patient697_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21363.7, + "Centroid Y µm": 36155.9, + "Num Detections": 22145, + "Num Negative": 21482, + "Num Positive": 663, + "Positive %": 2.994, + "Num Positive per mm^2": 286.34 + } +} \ No newline at end of file diff --git a/697/history_text.txt b/697/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..202e209261fbe864a56dfb2e5421ca0692409bec --- /dev/null +++ b/697/history_text.txt @@ -0,0 +1 @@ +Patient with a histologically confirmed G2 cT2 cN0 squamous cell carcinoma of the glottis and subglottis on both sides as a second carcinoma following CUP panendoscopy and neck dissection on the right and adjuvant radiotherapy up to 60 Gy in 2006 and current indication for the above-mentioned measures. \ No newline at end of file diff --git a/697/icd_codes.txt b/697/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/697/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/697/ops_codes.txt b/697/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7fcc264077b45d43ec7c3bf7bcaf7efdd9cd5ac4 --- /dev/null +++ b/697/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie ohne Rekonstruktion[5-303.00 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/697/patient_clinical_data.json b/697/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..95032de0472324e58b8fb013827a1c6dbc56d3f7 --- /dev/null +++ b/697/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 77, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/697/patient_pathological_data.json b/697/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..582e4c23a19110a148cbd792a9c91535f4409229 --- /dev/null +++ b/697/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "697", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.8", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/697/surgery_description.txt b/697/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d97c4e299171fdcd7e2ab47c775bb415651800c --- /dev/null +++ b/697/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Placement of nasogastric feeding tube diff --git a/697/surgery_report.txt b/697/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6251e39047a1b87da8e95765780d0a3f3756a7eb --- /dev/null +++ b/697/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia and transoral endotracheal intubation by the anesthesia colleagues and positioning of the patient by the surgeon. A laryngoscopy was performed using a Kleinsasser C-tube. This revealed a pronounced submucosal mass affecting the entire glottis and the subglottis on both sides over a distance of approx. 3 cm caudally. Thus, the indication for complete laryngectomy can be confirmed due to the pronounced subglottic tumor spread. Placement of a nasogastric feeding tube. Subsequent skin spray disinfection and application of local anesthesia cervically median, skin ablation and sterile draping. Due to the postoperative radiotherapy in the neck area and the lack of indication for neck dissection (postoperative neck dissection 2006, current cN0 status), the decision was made to make a circumscribed zigzag incision in the median cervical region. Dissection of the subcutaneous tissue and the platysma. Expose the prelaryngeal musculature and push it aside. Exposure from cranial to caudal of the hyoid bone, the thyroid cartilage, the cricoid cartilage and the anterior wall of the trachea. Exposure of the thyroid isthmus, transection of the same, treatment of the thyroid surface using bipolar coagulation. Subsequently, due to the clear subglottic extension of the tumor, decision to perform a deep tracheotomy between the 4th and 5th tracheal cartilage clasp. Re-intubation onto a size 8 laryngectomy tube, followed by skeletonization of the larynx, initially at the level of the thyroid cartilage. Perichondrium incision. Dissection of the piriform sinus from the thyroid cartilage leaves on both sides. Skeletonization of the hyoid bone with transection of the supra- and infrahyoid muscles at this level. Expose the epiglottis and perform the median pharyngotomy. Then incision along the aryepiglottic surfaces on both sides. Maximum protection of the piriform sinus on both sides. Transverse incision postcricoid and union of the lateral incisions. Entering the postcricoid area. Complete release of the larynx and the upper trachea from the postcricoid region and the esophagus. Dissection caudally. Resection and sending in of the laryngectomy specimen for intraoperative frozen section examination (suture marking: short-short tracheal separation margin anteriorly, long-long tracheal separation margin posteriorly). The following representative marginal samples are then taken: postcricoid region, right piriform sinus, left piriform sinus, right tongue base, left tongue base. All 5 marginal samples as well as the thread-marked areas on the laryngectomy specimen are found to be tumor-free by the pathology colleagues during the frozen section examination. Perform a cricopharyngeal myotomy. Subsequently, three-layer pharyngeal suture (submucosa, muscular layer, infrahyoid musculature). The pharyngeal suture is reinforced, particularly in the area of the base of the tongue, using cut pieces of Tachosil. Placement of a 10 Redon drain. Two-layer wound closure. Epithelialization of the tracheostoma at the caudal edge of the vertical skin incision. Re-intubation of the patient to a size 10 cannula. Application of a pressure dressing. Completion of the procedure without complications. The patient received Unacid 3 g intravenously intraoperatively as a single shot antibiotic. Please X-ray gruel swallow on the 10th postoperative day. \ No newline at end of file diff --git a/698/InvasionFront_CD3_block1_x5_y8_patient698_0.json b/698/InvasionFront_CD3_block1_x5_y8_patient698_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2942a71b8f58fbd2805f7daba6f8526d8170d361 --- /dev/null +++ b/698/InvasionFront_CD3_block1_x5_y8_patient698_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16303.9, + "Centroid Y µm": 22000.9, + "Num Detections": 24041, + "Num Negative": 20739, + "Num Positive": 3302, + "Positive %": 13.73, + "Num Positive per mm^2": 1442.9 + } +} \ No newline at end of file diff --git a/698/InvasionFront_CD3_block1_x6_y8_patient698_1.json b/698/InvasionFront_CD3_block1_x6_y8_patient698_1.json new file mode 100644 index 0000000000000000000000000000000000000000..888d9772082e3cab9136acd62da8277014170052 --- /dev/null +++ b/698/InvasionFront_CD3_block1_x6_y8_patient698_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18902.5, + "Centroid Y µm": 22088.3, + "Num Detections": 19939, + "Num Negative": 18736, + "Num Positive": 1203, + "Positive %": 6.033, + "Num Positive per mm^2": 578.16 + } +} \ No newline at end of file diff --git a/698/InvasionFront_CD8_block1_x5_y8_patient698_0.json b/698/InvasionFront_CD8_block1_x5_y8_patient698_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5163ecf24c468a21bb4b3ff4f7577cc6b7ff7c4b --- /dev/null +++ b/698/InvasionFront_CD8_block1_x5_y8_patient698_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16362.9, + "Centroid Y µm": 20506.2, + "Num Detections": 21098, + "Num Negative": 15118, + "Num Positive": 5980, + "Positive %": 28.34, + "Num Positive per mm^2": 2666.4 + } +} \ No newline at end of file diff --git a/698/InvasionFront_CD8_block1_x6_y8_patient698_1.json b/698/InvasionFront_CD8_block1_x6_y8_patient698_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a536b630621f6c89ae55362553a68f923bb1c597 --- /dev/null +++ b/698/InvasionFront_CD8_block1_x6_y8_patient698_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 20626.6, + "Num Detections": 17058, + "Num Negative": 13326, + "Num Positive": 3732, + "Positive %": 21.88, + "Num Positive per mm^2": 1914.1 + } +} \ No newline at end of file diff --git a/698/TumorCenter_CD3_block1_x5_y10_patient698_0.json b/698/TumorCenter_CD3_block1_x5_y10_patient698_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1cbcb1dab3839e5dd16df4da172454dec760b4e9 --- /dev/null +++ b/698/TumorCenter_CD3_block1_x5_y10_patient698_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 24786.9, + "Num Detections": 25519, + "Num Negative": 18937, + "Num Positive": 6582, + "Positive %": 25.79, + "Num Positive per mm^2": 2342.8 + } +} \ No newline at end of file diff --git a/698/TumorCenter_CD3_block1_x6_y10_patient698_1.json b/698/TumorCenter_CD3_block1_x6_y10_patient698_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7415f3c189df35df9a306f63871f1c1c5e1b21e4 --- /dev/null +++ b/698/TumorCenter_CD3_block1_x6_y10_patient698_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 24811.9, + "Num Detections": 18894, + "Num Negative": 16564, + "Num Positive": 2330, + "Positive %": 12.33, + "Num Positive per mm^2": 1107.4 + } +} \ No newline at end of file diff --git a/698/TumorCenter_CD8_block1_x5_y8_patient698_0.json b/698/TumorCenter_CD8_block1_x5_y8_patient698_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b2c9ff81f49aa702ec4389fe1c0eee966e71198b --- /dev/null +++ b/698/TumorCenter_CD8_block1_x5_y8_patient698_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 28734.8, + "Num Detections": 28653, + "Num Negative": 22091, + "Num Positive": 6562, + "Positive %": 22.9, + "Num Positive per mm^2": 2627.4 + } +} \ No newline at end of file diff --git a/698/TumorCenter_CD8_block1_x6_y8_patient698_1.json b/698/TumorCenter_CD8_block1_x6_y8_patient698_1.json new file mode 100644 index 0000000000000000000000000000000000000000..64232639616900444916c8f3bea3de367d3813a3 --- /dev/null +++ b/698/TumorCenter_CD8_block1_x6_y8_patient698_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21413.7, + "Centroid Y µm": 28759.8, + "Num Detections": 26709, + "Num Negative": 19223, + "Num Positive": 7486, + "Positive %": 28.03, + "Num Positive per mm^2": 2959.2 + } +} \ No newline at end of file diff --git a/698/history_text.txt b/698/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..db38b4cdfef51dec7ec321b5ebbe1e308313781c --- /dev/null +++ b/698/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma at the oropharyngeal/hypopharyngeal junction. The small tumor is located in the area of the transition from the base of the tongue to the pharyngeal side wall or the transition from the oropharyngeal side wall to the hypopharyngeal side wall. Therefore, the above-mentioned surgery is now indicated. \ No newline at end of file diff --git a/698/icd_codes.txt b/698/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3a5a10af7f9637797f93258b72590183676fb59c --- /dev/null +++ b/698/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 R] Bösartige Neubildung der hypopharyngealen Seite der aryepiglottischen Falte[C13.1 R] \ No newline at end of file diff --git a/698/ops_codes.txt b/698/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..594ed9c632b2a1684e84f5d5bbe6b73499979136 --- /dev/null +++ b/698/ops_codes.txt @@ -0,0 +1 @@ +CO2-Lasertechnik[5-985.1 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 R] \ No newline at end of file diff --git a/698/patient_clinical_data.json b/698/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c4a50fd0188d4ae2e72041777b81787b76cd3226 --- /dev/null +++ b/698/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/698/patient_pathological_data.json b/698/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..15f87114df53b0013ff64353430d17c15f7d39f2 --- /dev/null +++ b/698/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "698", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 14, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/698/surgery_description.txt b/698/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..90f3a05336606f6ecf147e32761fffdf5059c406 --- /dev/null +++ b/698/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Neck dissection, PEG placement diff --git a/698/surgery_report.txt b/698/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c41832e7b684c8f284838c1a82a417350df8ba9 --- /dev/null +++ b/698/surgery_report.txt @@ -0,0 +1 @@ +Initial PEG insertion: insertion with the gastroscope. After creating the diaphanoscopy, easy insertion of a 15 mm abdominal wall tube. Typical fixation to the abdominal wall. Subsequent repositioning for laser resection: insertion with the spreading laryngoscope. Exposure of the tumor, which is successful. Using the CO2 laser with a power of 5-7 watts, the tumor is successively cut around the healthy tissue. In the caudal-medial area, a small mucosal change is seen, which is also suspicious and is about 1 cm away from the main tumor. This is included in the resection. The specimen is then removed and thread-marked and sent for frozen section. A medial margin sample is also taken and sent for frozen section. Medial margin specimen with at least moderate dysplasia according to pathology. Therefore resection recommended. Relatively scarce in the main preparation after basal, although there were microscopically good margins here. Post-resection also recommended here. Therefore, another resection is recommended. A further layer is removed laterally from the muscle wall. A passing nerve, probably the superior laryngeal nerve, is spared. Subsequently, another marginal sample is taken from the medial edge of the temporal bone, in which the dysplasia was detected. Both are sent for final diagnosis. Subsequent careful hemostasis. Repositioning for neck dissection: skin disinfection. Injection of a total of 10 ml Ultracaine 1% with adrenaline. Then sterile draping. Incision in a typical curved fashion in front of the sternocleidomastoid muscle. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and the digastric muscle. Exposure of the internal jugular vein, external jugular vein, internal/external carotid artery, vagus nerve, hypoglossal nerve and accessorius nerve. Successive removal of the level II to IV lymph nodes while exposing and preserving the branches of the cervical plexus. Subsequent careful hemostasis. Wound closure in layers with insertion of a Redon drain. Completion of the procedure without complications. Check the enoral situation again at the end. No bleeding here. Overall small carcinoma at the oro-/hypopharyngeal junction, which was resected again basally due to a narrow margin and medially due to dysplasia. Neck dissection on the right. Postoperative loosening of the PEG in a typical manner on the following day. Antibiotics, which were given, should be continued for one week. After receiving the final histology, further procedure or presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/699/InvasionFront_CD3_block14_x1_y12_patient699_0.json b/699/InvasionFront_CD3_block14_x1_y12_patient699_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9bf354d52f9bd8a52859ff190464113a0c7ed08c --- /dev/null +++ b/699/InvasionFront_CD3_block14_x1_y12_patient699_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 33607.2, + "Num Detections": 16664, + "Num Negative": 16077, + "Num Positive": 587, + "Positive %": 3.523, + "Num Positive per mm^2": 283.3 + } +} \ No newline at end of file diff --git a/699/InvasionFront_CD3_block14_x2_y12_patient699_1.json b/699/InvasionFront_CD3_block14_x2_y12_patient699_1.json new file mode 100644 index 0000000000000000000000000000000000000000..30f740891542cc6c7f43e2e5ccdd3ad20f18821e --- /dev/null +++ b/699/InvasionFront_CD3_block14_x2_y12_patient699_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6621.5, + "Centroid Y µm": 33682.2, + "Num Detections": 13465, + "Num Negative": 13392, + "Num Positive": 73, + "Positive %": 0.5421, + "Num Positive per mm^2": 38.64 + } +} \ No newline at end of file diff --git a/699/InvasionFront_CD8_block14_x1_y12_patient699_0.json b/699/InvasionFront_CD8_block14_x1_y12_patient699_0.json new file mode 100644 index 0000000000000000000000000000000000000000..422ce37c60ad88b2e1a29547c51ae8fbbe168f68 --- /dev/null +++ b/699/InvasionFront_CD8_block14_x1_y12_patient699_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4497.6, + "Centroid Y µm": 29059.6, + "Num Detections": 18682, + "Num Negative": 17643, + "Num Positive": 1039, + "Positive %": 5.562, + "Num Positive per mm^2": 460.98 + } +} \ No newline at end of file diff --git a/699/InvasionFront_CD8_block14_x2_y12_patient699_1.json b/699/InvasionFront_CD8_block14_x2_y12_patient699_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f737cd82823cacf96d16cc858ca9639d53b65312 --- /dev/null +++ b/699/InvasionFront_CD8_block14_x2_y12_patient699_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 29159.6, + "Num Detections": 17437, + "Num Negative": 16996, + "Num Positive": 441, + "Positive %": 2.529, + "Num Positive per mm^2": 211.56 + } +} \ No newline at end of file diff --git a/699/TumorCenter_CD8_block14_x1_y12_patient699_0.json b/699/TumorCenter_CD8_block14_x1_y12_patient699_0.json new file mode 100644 index 0000000000000000000000000000000000000000..83c556ee5424c0f663996e5b08da9b14a648b2a1 --- /dev/null +++ b/699/TumorCenter_CD8_block14_x1_y12_patient699_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3248.3, + "Centroid Y µm": 30309.0, + "Num Detections": 18466, + "Num Negative": 18282, + "Num Positive": 184, + "Positive %": 0.9964, + "Num Positive per mm^2": 77.5 + } +} \ No newline at end of file diff --git a/699/TumorCenter_CD8_block14_x2_y12_patient699_1.json b/699/TumorCenter_CD8_block14_x2_y12_patient699_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6220a99d9e3aba8db0614db12363ab901568c817 --- /dev/null +++ b/699/TumorCenter_CD8_block14_x2_y12_patient699_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5771.9, + "Centroid Y µm": 30309.0, + "Num Detections": 16842, + "Num Negative": 16272, + "Num Positive": 570, + "Positive %": 3.384, + "Num Positive per mm^2": 272.59 + } +} \ No newline at end of file diff --git a/699/history_text.txt b/699/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..bce4b99e9f50c3e276d28b5ed257a6dcb41ea032 --- /dev/null +++ b/699/history_text.txt @@ -0,0 +1 @@ +The patient presented with an external histology of the left edge of the tongue. This revealed a squamous cell carcinoma. Therefore indication for the above procedure. \ No newline at end of file diff --git a/699/icd_codes.txt b/699/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/699/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/699/ops_codes.txt b/699/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c648400211954e7c37157d49e8884b6d9e3cccfc --- /dev/null +++ b/699/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Zungentumorexzision[5-250.2 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 L] \ No newline at end of file diff --git a/699/patient_clinical_data.json b/699/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0d20ad343b3e2e0dd5ee99392e77409c4a16f68e --- /dev/null +++ b/699/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 90, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/699/patient_pathological_data.json b/699/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..75cb4d903d970816113e2c2f72fbbe46fe73096c --- /dev/null +++ b/699/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "699", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/699/surgery_description.txt b/699/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..592b55e920e73eedf2ebc14e789ae6815ae834ee --- /dev/null +++ b/699/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, PEG placement, Modified radical neck dissection, Transoral tumor resection diff --git a/699/surgery_report.txt b/699/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7ccdab70752087cc80d12d44b771497c3158fb1a --- /dev/null +++ b/699/surgery_report.txt @@ -0,0 +1 @@ +Panendoscopy was first performed by . No abnormalities except for the previously described mass in the area of the tongue margin. Unfortunately, there is a tear in the mucosa in the glossotonsillar groove on the right side due to the small esophageal tube. Entering with the flexible esophagoscope and endoscopy into the stomach. No abnormalities in either the esophagus or the stomach. PEG insertion using the thread pull-through method with good diaphanoscopy and no complications. Positioning of the head and insertion of the spandex. Snaring of the tongue and takeover of the operation by . Marking the edges of the incision using bipolar forceps and cutting around and dissecting out the tumor with a safety margin of 1 cm. The specimen is sent to the pathology department on cork. Removal of representative marginal samples. The marginal samples show a carcinoma in situ of the mucosa on the dorsal side. At the end, a resection and another marginal sample are taken, which are sent for final histology. Repositioning for neck dissection on the left side. Sterile washing and draping. Injection of Ultracaine mixture beforehand. Skin incision in a transverse skin fold. Exposure of the platysma. Separation of the platysma. Formation of a platysmal flap cranially. Exposure of the omohyoid muscle, the sternocleidomastoid muscle, the submandibular gland, the facial vein and the cervical vascular sheath. Free preparation of the internal jugular vein. Release of the medial neck block. Exposure of the accessorius and release of the neck levels II a to IV while sparing the plexus branches. Evacuation of neck levels Ia and b, as the tumor extends very far anteriorly and also partially to the anterior floor of the mouth. Insertion of a Redon drainage. Two-layer wound closure. Completion of the procedure without complications. \ No newline at end of file diff --git a/700/InvasionFront_CD3_block13_x3_y10_patient700_0.json b/700/InvasionFront_CD3_block13_x3_y10_patient700_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b7640f2eb62aa9b45611a9a517fbfaeab87ed0c --- /dev/null +++ b/700/InvasionFront_CD3_block13_x3_y10_patient700_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 24187.2, + "Num Detections": 18748, + "Num Negative": 16475, + "Num Positive": 2273, + "Positive %": 12.12, + "Num Positive per mm^2": 979.42 + } +} \ No newline at end of file diff --git a/700/InvasionFront_CD3_block13_x4_y10_patient700_1.json b/700/InvasionFront_CD3_block13_x4_y10_patient700_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1460754f5fe0cbf5d27643bd76927c581d6896f4 --- /dev/null +++ b/700/InvasionFront_CD3_block13_x4_y10_patient700_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 24137.2, + "Num Detections": 22550, + "Num Negative": 21851, + "Num Positive": 699, + "Positive %": 3.1, + "Num Positive per mm^2": 278.2 + } +} \ No newline at end of file diff --git a/700/InvasionFront_CD8_block13_x3_y10_patient700_0.json b/700/InvasionFront_CD8_block13_x3_y10_patient700_0.json new file mode 100644 index 0000000000000000000000000000000000000000..152f01b8cfa0a15040d1d8899d0bf92dd821ebe5 --- /dev/null +++ b/700/InvasionFront_CD8_block13_x3_y10_patient700_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11593.9, + "Centroid Y µm": 25936.3, + "Num Detections": 21122, + "Num Negative": 19380, + "Num Positive": 1742, + "Positive %": 8.247, + "Num Positive per mm^2": 729.53 + } +} \ No newline at end of file diff --git a/700/InvasionFront_CD8_block13_x4_y10_patient700_1.json b/700/InvasionFront_CD8_block13_x4_y10_patient700_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2187a6853f01cf3abc954fe4865da29349be2e56 --- /dev/null +++ b/700/InvasionFront_CD8_block13_x4_y10_patient700_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 26061.2, + "Num Detections": 24552, + "Num Negative": 24328, + "Num Positive": 224, + "Positive %": 0.9123, + "Num Positive per mm^2": 86.9 + } +} \ No newline at end of file diff --git a/700/TumorCenter_CD3_block13_x3_y10_patient700_0.json b/700/TumorCenter_CD3_block13_x3_y10_patient700_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c68c0deaa586e0702008e6c272a2378ad579cd76 --- /dev/null +++ b/700/TumorCenter_CD3_block13_x3_y10_patient700_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11094.1, + "Centroid Y µm": 31408.4, + "Num Detections": 26007, + "Num Negative": 25797, + "Num Positive": 210, + "Positive %": 0.8075, + "Num Positive per mm^2": 77.53 + } +} \ No newline at end of file diff --git a/700/TumorCenter_CD3_block13_x4_y10_patient700_1.json b/700/TumorCenter_CD3_block13_x4_y10_patient700_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c2d0d1adce2767a01d535650cc91af8bf487c145 --- /dev/null +++ b/700/TumorCenter_CD3_block13_x4_y10_patient700_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 31608.3, + "Num Detections": 24415, + "Num Negative": 23469, + "Num Positive": 946, + "Positive %": 3.875, + "Num Positive per mm^2": 368.58 + } +} \ No newline at end of file diff --git a/700/TumorCenter_CD8_block13_x3_y10_patient700_0.json b/700/TumorCenter_CD8_block13_x3_y10_patient700_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fcdd140db3a71194ca2535debb9f9466c493bb28 --- /dev/null +++ b/700/TumorCenter_CD8_block13_x3_y10_patient700_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13043.1, + "Centroid Y µm": 24836.8, + "Num Detections": 19153, + "Num Negative": 19122, + "Num Positive": 31, + "Positive %": 0.1619, + "Num Positive per mm^2": 15.06 + } +} \ No newline at end of file diff --git a/700/TumorCenter_CD8_block13_x4_y10_patient700_1.json b/700/TumorCenter_CD8_block13_x4_y10_patient700_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d0789286512e85d0398a070c796c65c4334efbc5 --- /dev/null +++ b/700/TumorCenter_CD8_block13_x4_y10_patient700_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15591.7, + "Centroid Y µm": 24537.0, + "Num Detections": 22722, + "Num Negative": 22403, + "Num Positive": 319, + "Positive %": 1.404, + "Num Positive per mm^2": 130.83 + } +} \ No newline at end of file diff --git a/700/history_text.txt b/700/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1c6fb6adc698a0bcd5b84375ff834bb642e0b31 --- /dev/null +++ b/700/history_text.txt @@ -0,0 +1 @@ +History of unclear cervical mass on the right side for almost 4 months. In the course of a panendoscopy, a cT1 cN2a G3 differentiated oropharyngeal carcinoma was histologically confirmed. There is now an indication for transoral resection, neck dissection and PEG placement. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/700/icd_codes.txt b/700/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1f185ed365f69875a3640ee9ac0bbcb98e5f463 --- /dev/null +++ b/700/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx Seitenwand[C10.2 R] \ No newline at end of file diff --git a/700/ops_codes.txt b/700/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8330f590d9c5a9804f73fc394cfdfc4337cf527a --- /dev/null +++ b/700/ops_codes.txt @@ -0,0 +1 @@ +Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 R] Partielle Parotidektomie mit Fazialismonitoring[5-262.01 R] \ No newline at end of file diff --git a/700/patient_clinical_data.json b/700/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..52a185827457cc7faf88b326e6ebfefee0974cbc --- /dev/null +++ b/700/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/700/patient_pathological_data.json b/700/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e4b4ac6be2853fe1ea8ecdf4379adcee33f7c976 --- /dev/null +++ b/700/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "700", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 11, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/700/surgery_description.txt b/700/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..48a3025dda985cf1dcc312482ee8a3100506a8e8 --- /dev/null +++ b/700/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Neck dissection, and PEG placement diff --git a/700/surgery_report.txt b/700/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..38b9604e0b578751720769b8a3f6f2114c260ac7 --- /dev/null +++ b/700/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Team time-out and induction of anesthesia by the anesthesia colleagues. The oropharyngoscopy is performed first. This reveals the tumor described above, which appears to be located in the area of the glossotonsillar groove. Ventral extension to the middle third of the anterior palatal arch. Subsequently transition to the glossotonsillar groove and into the base of the tongue. The tumor is relatively difficult to palpate as it grows largely submucosally in the area of the base of the tongue. Transition to PEG placement. The endoscope is inserted under visualization and air is constantly insufflated into the stomach. Here the gastric mucosa is inconspicuous on all sides. After a clear positive diaphanoscopy, the PEG tube is inserted using the thread pull-through method in the typical manner. This was performed without any problems. The patient was given 3 g Unacid preoperatively. The patient was then repositioned for transoral tumor resection. Insertion of the self-retaining Jennings retractor and suturing of the tongue. Luxation of the tongue and renewed palpatory identification of the tumor borders. Start of resection in the area of the anterior palatal arch with the electric needle. Resection down to the tonsil. As the tumor extensions are relatively close to the tonsil tissue, the decision is made to resect the tonsil en bloc as well. With constant palpatory identification of the tumor borders, the tumor is successively resected with a clinically macroscopically wide safety margin. In between, bipolar coagulation of small arterial bleedings is performed. The suture marking of the primary tumor is still performed in situ. The anterior margin of the posterior third of the tongue and the glossotonsillar groove as well as the margin of the anterior palatal arch and the medial base of the tongue are marked with sutures. Hemostasis by means of bipolar coagulation. Insertion of an H2O2-soaked hydrogen compress. In the meantime, the specimen has been sent for frozen section diagnostics. Repositioning of the patient for neck dissection. Superficial skin disinfection and sterile draping. Mark the planned incision from preauricular to infrolobular and curved towards the caudal side in a bayonet shape in the area of the sternocleidomastoid muscle anterior margin. Sharp transection of the cutis and subcutis. Exposure of the sternocleidomastoid muscle. Exposure and initial protection of the auricularis magnus nerve. Exposure of the omohyoid muscle as the cranial border as well as the submandibular gland and the digastric muscle as the cranial border. Turn to the cervical vascular sheath. Dissection of the internal jugular vein and the external and internal carotid arteries. Level II shows that the tumor infiltrates the sternocleidomastoid broadly. The decision was therefore made to resect the sternocleidomastoid muscle. This is done using the electric knife, initially caudally. Cranially, the metastatic conglomerate is firmly seated in level II b and appears to infiltrate the caudal parotid pole. The tumor extensions reach up to the carotid bifurcation. However, the tumor can be separated from the external carotid artery and the first branches as well as the internal carotid artery with the Reynold scissors. Exposure and protection of the vagus nerve. It is also apparent that the internal jugular vein is infiltrated cranially by the tumor. It was therefore decided to remove it as well. Double ligation of the same caudally and single ligation cranially. The tumor extends cranially under the digastric muscle. Therefore, removal of the same and lateral beating of the muscle belly. You now have a good view of the internal carotid artery and all external branches. Expose the superior thyroid artery, the lingual artery, the facial artery and the ascending pharyngeal artery. As the tumor also infiltrates the caudal parotid pole, the incision is extended cranially to secure the marginal ramus and the glandular capsule is exposed. Expose the cartilaginous pointer and the main facial trunk. Subsequently, successive dissection along the main trunk and exposure of the frontofacial and cervicofacial bundle. The cervicofacial bundle is dissected further into the periphery, carefully monitoring the marginal ramus. The laterocaudal part of the parotid gland is then removed while sparing the marginal mandibular nerve. The digastric muscle is also dissected dorsally. The same applies to the accessorius nerve, which is also located in the tumor conglomerate. After laborious dissection, the metastatic block can be removed in toto. Only in the area of the carotid bifurcation does a tumor remnant still appear to be present macroscopically. Therefore, meticulous dissection along the vessels and removal of the questionably infiltrated material. Despite the preoperatively small tumor extension, the tumor appears to grow diffusely infiltrating intraoperatively. The dissection extends as far as the pharyngeal musculature. No macroscopic tumor remnants here. Subsequent removal of the remaining medial and lateral neck specimen. Overall removal of levels II to V. Hemostasis using bipolar coagulation. Wound irrigation with H2O2 and NACL. Insertion of a Redon drainage as well as subcutaneous suture and skin suture. Application of a wound dressing. In the meantime, rapid incision announcement by telephone. Microscopic suspicion of R1 status in the area of the wound bed at the anterior margin of the posterior third of the tongue. The patient is therefore repositioned for transoral resection. The complete wound bed is resected and sent for definitive histology (resection of the wound bed of the posterior third of the tongue at the front and resection of the wound bed of the posterior third of the tongue at the back). Subsequently, definitive marginal samples were taken in the area of the wound bed (posterior third of the tongue at the front, posterior third of the tongue at the back). Extensive hemostasis using bipolar coagulation. Transfer of the patient intubated and ventilated to the local intensive care unit, as a tracheotomy had not been discussed and planned with the patient in advance. The operation was completed without complications. Conclusion: Due to the extensive and diffuse tumor growth, the patient should be advised to undergo adjuvant radiochemotherapy postoperatively. \ No newline at end of file diff --git a/701/InvasionFront_CD3_block7_x1_y8_patient701_0.json b/701/InvasionFront_CD3_block7_x1_y8_patient701_0.json new file mode 100644 index 0000000000000000000000000000000000000000..595fb88c740d9201128b1967554cd3e36667b3d2 --- /dev/null +++ b/701/InvasionFront_CD3_block7_x1_y8_patient701_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4147.8, + "Centroid Y µm": 19564.6, + "Num Detections": 20859, + "Num Negative": 19529, + "Num Positive": 1330, + "Positive %": 6.376, + "Num Positive per mm^2": 534.36 + } +} \ No newline at end of file diff --git a/701/InvasionFront_CD3_block7_x2_y8_patient701_1.json b/701/InvasionFront_CD3_block7_x2_y8_patient701_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5ad054b43014c5dd9ce4a6a4eb400fec492e1099 --- /dev/null +++ b/701/InvasionFront_CD3_block7_x2_y8_patient701_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 19539.7, + "Num Detections": 19692, + "Num Negative": 18616, + "Num Positive": 1076, + "Positive %": 5.464, + "Num Positive per mm^2": 445.97 + } +} \ No newline at end of file diff --git a/701/InvasionFront_CD8_block7_x1_y8_patient701_0.json b/701/InvasionFront_CD8_block7_x1_y8_patient701_0.json new file mode 100644 index 0000000000000000000000000000000000000000..68eee304ed8833da2587a2ec674a5a0a7afc08fe --- /dev/null +++ b/701/InvasionFront_CD8_block7_x1_y8_patient701_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4497.6, + "Centroid Y µm": 19564.6, + "Num Detections": 20195, + "Num Negative": 18324, + "Num Positive": 1871, + "Positive %": 9.265, + "Num Positive per mm^2": 776.69 + } +} \ No newline at end of file diff --git a/701/InvasionFront_CD8_block7_x2_y8_patient701_1.json b/701/InvasionFront_CD8_block7_x2_y8_patient701_1.json new file mode 100644 index 0000000000000000000000000000000000000000..439024056835ddc802e2fa257d3f85e1eb37cad7 --- /dev/null +++ b/701/InvasionFront_CD8_block7_x2_y8_patient701_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6871.4, + "Centroid Y µm": 19814.5, + "Num Detections": 21169, + "Num Negative": 20497, + "Num Positive": 672, + "Positive %": 3.174, + "Num Positive per mm^2": 271.03 + } +} \ No newline at end of file diff --git a/701/TumorCenter_CD3_block7_x1_y8_patient701_0.json b/701/TumorCenter_CD3_block7_x1_y8_patient701_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5f31e217fa3954487d5bdd09db570b9675083741 --- /dev/null +++ b/701/TumorCenter_CD3_block7_x1_y8_patient701_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3498.1, + "Centroid Y µm": 20014.4, + "Num Detections": 19118, + "Num Negative": 14446, + "Num Positive": 4672, + "Positive %": 24.44, + "Num Positive per mm^2": 1859.1 + } +} \ No newline at end of file diff --git a/701/TumorCenter_CD3_block7_x2_y8_patient701_1.json b/701/TumorCenter_CD3_block7_x2_y8_patient701_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c53c0a3f34b43bb0203eb4e058e24620a06aa7c --- /dev/null +++ b/701/TumorCenter_CD3_block7_x2_y8_patient701_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 20189.3, + "Num Detections": 20594, + "Num Negative": 19391, + "Num Positive": 1203, + "Positive %": 5.842, + "Num Positive per mm^2": 503.75 + } +} \ No newline at end of file diff --git a/701/TumorCenter_CD8_block7_x1_y8_patient701_0.json b/701/TumorCenter_CD8_block7_x1_y8_patient701_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c44deb080df14ac4920a3a47bb14199ca95139be --- /dev/null +++ b/701/TumorCenter_CD8_block7_x1_y8_patient701_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 19964.4, + "Num Detections": 21416, + "Num Negative": 18194, + "Num Positive": 3222, + "Positive %": 15.04, + "Num Positive per mm^2": 1330.5 + } +} \ No newline at end of file diff --git a/701/TumorCenter_CD8_block7_x2_y8_patient701_1.json b/701/TumorCenter_CD8_block7_x2_y8_patient701_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e27c899dbcadf1f12a09b73ce85f4749a4f3df8a --- /dev/null +++ b/701/TumorCenter_CD8_block7_x2_y8_patient701_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5896.9, + "Centroid Y µm": 20064.4, + "Num Detections": 21466, + "Num Negative": 21227, + "Num Positive": 239, + "Positive %": 1.113, + "Num Positive per mm^2": 100.06 + } +} \ No newline at end of file diff --git a/701/history_text.txt b/701/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..477fc860364e352dc90271573e6001ff4d9878c7 --- /dev/null +++ b/701/history_text.txt @@ -0,0 +1 @@ +Post-transoral resection of a pT1a pN2a oral cavity carcinoma in 2014 with adjuvant simultaneous radiochemotherapy as well as dose saturation using interstitial brachytherapy. As part of the regular tumor follow-up, a slightly suspicious change in the mucosa in the area of the left-sided glossotonsillar groove was discovered. There is now an indication for panendoscopy and excision biopsy in the area of the left glossotonsillar groove. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/701/icd_codes.txt b/701/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..da55c7511d068fc0b0dfe7e6a45d4d38eecf0a89 --- /dev/null +++ b/701/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/701/ops_codes.txt b/701/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d30cf1b2aaf2500f1eded3e866311bdb7f4056e --- /dev/null +++ b/701/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Biopsie Oropharynx onA durch Inzision[1-546 ] \ No newline at end of file diff --git a/701/patient_clinical_data.json b/701/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9b13e0f4de489f098c86ae8f4bbe558288cc2567 --- /dev/null +++ b/701/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 60, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/701/patient_pathological_data.json b/701/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2068cd985935482c86ee5c3445a6bd7b76cb4a8d --- /dev/null +++ b/701/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "701", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris1", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 19.0 +} \ No newline at end of file diff --git a/701/surgery_description.txt b/701/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2c3b6da0e85c473c3a687c99999a9c5156c11ca --- /dev/null +++ b/701/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy on the oropharynx diff --git a/701/surgery_report.txt b/701/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..775052a14afba49f19934f7171529ebad03e7a15 --- /dev/null +++ b/701/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is admitted to the operating theater. Carrying out the team time-out. Introductory consultation with the anesthesia department. Induction of anesthesia and intubation of the patient. Positioning of the patient by the surgeon. Insertion of the mouth guard. Entry with the small bore tube and initial adjustment of the endolarynx. This appears unremarkable. Inspection of the hypopharynx on both sides. This is lined on all sides by smooth mucosa and can be freely unfolded up to the tip. Postcricoid as well as in the area of the esophageal entrance are also inconspicuous. Entry with the reinforced retractor and inspection of the glossotonsillar groove on the left side. The slightly suspicious, exophytic mucosal change described above can be seen here. The area is now circumcised using the electric needle. The tissue is sent for urgent histology. Hemostasis by means of bipolar coagulation. Final inspection of the oral cavity. There is no evidence of a further tumor-specific lesion. Final consultation with the anesthesiologist. Completion of the operation without complications. \ No newline at end of file diff --git a/702/InvasionFront_CD3_block15_x1_y9_patient702_0.json b/702/InvasionFront_CD3_block15_x1_y9_patient702_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7f9313c7de134bcaf2e025a3489f592150e93316 --- /dev/null +++ b/702/InvasionFront_CD3_block15_x1_y9_patient702_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 33007.5, + "Num Detections": 17451, + "Num Negative": 15615, + "Num Positive": 1836, + "Positive %": 10.52, + "Num Positive per mm^2": 792.47 + } +} \ No newline at end of file diff --git a/702/InvasionFront_CD3_block15_x2_y9_patient702_1.json b/702/InvasionFront_CD3_block15_x2_y9_patient702_1.json new file mode 100644 index 0000000000000000000000000000000000000000..47093912bca55c1ed7a78234f7acecbb01a568b9 --- /dev/null +++ b/702/InvasionFront_CD3_block15_x2_y9_patient702_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8920.3, + "Centroid Y µm": 32957.5, + "Num Detections": 11264, + "Num Negative": 10371, + "Num Positive": 893, + "Positive %": 7.928, + "Num Positive per mm^2": 677.3 + } +} \ No newline at end of file diff --git a/702/InvasionFront_CD8_block15_x1_y9_patient702_0.json b/702/InvasionFront_CD8_block15_x1_y9_patient702_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7bdd4deda7da65faee6c760413468da50980f1a3 --- /dev/null +++ b/702/InvasionFront_CD8_block15_x1_y9_patient702_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4291.9, + "Centroid Y µm": 22334.6, + "Num Detections": 14092, + "Num Negative": 13402, + "Num Positive": 690, + "Positive %": 4.896, + "Num Positive per mm^2": 328.87 + } +} \ No newline at end of file diff --git a/702/InvasionFront_CD8_block15_x2_y9_patient702_1.json b/702/InvasionFront_CD8_block15_x2_y9_patient702_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c3a1fef4005012cf541de52bb69557d9d0c2e6d --- /dev/null +++ b/702/InvasionFront_CD8_block15_x2_y9_patient702_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6661.8, + "Centroid Y µm": 22273.8, + "Num Detections": 12893, + "Num Negative": 12100, + "Num Positive": 793, + "Positive %": 6.151, + "Num Positive per mm^2": 514.97 + } +} \ No newline at end of file diff --git a/702/TumorCenter_CD3_block15_x1_y9_patient702_0.json b/702/TumorCenter_CD3_block15_x1_y9_patient702_0.json new file mode 100644 index 0000000000000000000000000000000000000000..07d533f0f9f1c52fd7a8209b0ebcad318be22e0d --- /dev/null +++ b/702/TumorCenter_CD3_block15_x1_y9_patient702_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 25736.4, + "Num Detections": 17950, + "Num Negative": 16933, + "Num Positive": 1017, + "Positive %": 5.666, + "Num Positive per mm^2": 437.01 + } +} \ No newline at end of file diff --git a/702/TumorCenter_CD3_block15_x2_y9_patient702_1.json b/702/TumorCenter_CD3_block15_x2_y9_patient702_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4d46f1b22fce6e5f4eb941ee34481bf094ce1ab8 --- /dev/null +++ b/702/TumorCenter_CD3_block15_x2_y9_patient702_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 25811.3, + "Num Detections": 17778, + "Num Negative": 16831, + "Num Positive": 947, + "Positive %": 5.327, + "Num Positive per mm^2": 413.54 + } +} \ No newline at end of file diff --git a/702/TumorCenter_CD8_block15_x1_y9_patient702_0.json b/702/TumorCenter_CD8_block15_x1_y9_patient702_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c04865300d6c3ba3d24b13ad89c9cf2a4da48b8f --- /dev/null +++ b/702/TumorCenter_CD8_block15_x1_y9_patient702_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 22338.2, + "Num Detections": 16022, + "Num Negative": 15670, + "Num Positive": 352, + "Positive %": 2.197, + "Num Positive per mm^2": 155.78 + } +} \ No newline at end of file diff --git a/702/TumorCenter_CD8_block15_x2_y9_patient702_1.json b/702/TumorCenter_CD8_block15_x2_y9_patient702_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6e7ad45a9aa823899a565e01e4550fef8e08b112 --- /dev/null +++ b/702/TumorCenter_CD8_block15_x2_y9_patient702_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8870.3, + "Centroid Y µm": 22388.1, + "Num Detections": 15650, + "Num Negative": 15334, + "Num Positive": 316, + "Positive %": 2.019, + "Num Positive per mm^2": 139.41 + } +} \ No newline at end of file diff --git a/702/history_text.txt b/702/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/702/icd_codes.txt b/702/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ff2082a0115c5d5aa669e34936cf7d1a67d017e9 --- /dev/null +++ b/702/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 R] \ No newline at end of file diff --git a/702/ops_codes.txt b/702/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aef69163c6fd26f7987d12da544e214135da8d73 --- /dev/null +++ b/702/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] \ No newline at end of file diff --git a/702/patient_clinical_data.json b/702/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bfc69f3f0426989913dcc582dfcff32b6c215508 --- /dev/null +++ b/702/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/702/patient_pathological_data.json b/702/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2597b61319bf6be1c22390ee10231024393022e0 --- /dev/null +++ b/702/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "702", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/702/surgery_description.txt b/702/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1b3ff6659f50ed31123b8298b1ade7fcb5db9b3 --- /dev/null +++ b/702/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Neck dissection diff --git a/702/surgery_report.txt b/702/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1db8e78cad90451a943a54f3b78645957f2043b9 --- /dev/null +++ b/702/surgery_report.txt @@ -0,0 +1 @@ +First, position the patient and re-inspect the surgical site with the Kleinsasser tube. The exulcerating lesion described above is seen on the edge of the tongue on the right side in the posterior third. The tongue is indurated up to the base of the tongue. Then insertion of the Lars retractor and suturing of the tongue. Then position the Da Vinci system. A very good overview of the tumor findings is obtained. Then robot-assisted excision of the tumor from front to back. The base of the tongue itself appears tumor-free. The specimen is then thread-marked and sent for histopathological examination. Careful hemostasis is performed in the meantime. A frozen section shows the tumor removed in toto and in sano. The minimum distance to the healthy tissue is 4 mm. Careful control of bleeding again and then removal of the Da Vinci system, the Lars retractor and the tongue suture. Then reposition the patient for neck dissection on the right side with CN0 neck status. Injection of local anesthetic with adrenaline in the area of the anterior sternocleidomastoid muscle. Subsequent incision along the sternocleidomastoid muscle and layered dissection in depth. Cut through the plastysma. The external jugular vein. Further dissection in depth. Then expose the cervical vascular sheath. Locate the omohyoid muscle. Locate the digaster venter posterior muscle. Locate the accessorius nerve. Subsequent exposure of the cervical vascular sheath. Long-distance dissection of the vagus nerve, which is dissected out of its bed in the sense of a neurolysis and moved medially. Long-distance dissection of the accessorius nerve and neurolysis, displacement and re-embedding of the nerve. Then remove the lateral neck preparation in accordance with levels II, III and some IV. Now dissection of the vein angle and level I b. Here, also long-distance dissection of the hypoglossal nerve, which is preserved together with the ansa. Here, too, neurolysis, displacement and re-embedding of the nerve. Preservation of the facial vein. Then complete removal of the anterior neck preparation with all outlets, the internal jugular vein and external carotid artery. The thyroid vein originates from the facial vein. The entire vascular-nerve bundle is also gently dissected and preserved here. Then careful hemostasis. Insertion of a Redon drain. Then two-layer wound closure and dressing. After completion of the procedure and also at the beginning of the procedure, consultation with the anesthesia colleagues. A decision was then made to transfer the patient to the ENT intensive care unit for monitoring. \ No newline at end of file diff --git a/703/InvasionFront_CD3_block12_x5_y10_patient703_0.json b/703/InvasionFront_CD3_block12_x5_y10_patient703_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7c83ade2fe263df54b2be647c4099588d3127228 --- /dev/null +++ b/703/InvasionFront_CD3_block12_x5_y10_patient703_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15616.7, + "Centroid Y µm": 29959.1, + "Num Detections": 15556, + "Num Negative": 15191, + "Num Positive": 365, + "Positive %": 2.346, + "Num Positive per mm^2": 159.9 + } +} \ No newline at end of file diff --git a/703/InvasionFront_CD3_block12_x6_y10_patient703_1.json b/703/InvasionFront_CD3_block12_x6_y10_patient703_1.json new file mode 100644 index 0000000000000000000000000000000000000000..31bded8502922c9c61451c2704ad17b6533c51be --- /dev/null +++ b/703/InvasionFront_CD3_block12_x6_y10_patient703_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18215.4, + "Centroid Y µm": 30234.0, + "Num Detections": 19861, + "Num Negative": 19462, + "Num Positive": 399, + "Positive %": 2.009, + "Num Positive per mm^2": 182.13 + } +} \ No newline at end of file diff --git a/703/InvasionFront_CD8_block12_x5_y10_patient703_0.json b/703/InvasionFront_CD8_block12_x5_y10_patient703_0.json new file mode 100644 index 0000000000000000000000000000000000000000..717731abcde51c4e95152d788cfe9e2690b7619f --- /dev/null +++ b/703/InvasionFront_CD8_block12_x5_y10_patient703_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17640.7, + "Centroid Y µm": 28659.8, + "Num Detections": 14121, + "Num Negative": 14000, + "Num Positive": 121, + "Positive %": 0.8569, + "Num Positive per mm^2": 55.11 + } +} \ No newline at end of file diff --git a/703/InvasionFront_CD8_block12_x6_y10_patient703_1.json b/703/InvasionFront_CD8_block12_x6_y10_patient703_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3caa82bf0441017c0b754b9db56491b52371961e --- /dev/null +++ b/703/InvasionFront_CD8_block12_x6_y10_patient703_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20214.3, + "Centroid Y µm": 28634.8, + "Num Detections": 18905, + "Num Negative": 18771, + "Num Positive": 134, + "Positive %": 0.7088, + "Num Positive per mm^2": 61.19 + } +} \ No newline at end of file diff --git a/703/TumorCenter_CD3_block12_x5_y10_patient703_0.json b/703/TumorCenter_CD3_block12_x5_y10_patient703_0.json new file mode 100644 index 0000000000000000000000000000000000000000..98bb3a9ffeae60ede65cddcf21e860afd4cde098 --- /dev/null +++ b/703/TumorCenter_CD3_block12_x5_y10_patient703_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15441.8, + "Centroid Y µm": 25011.8, + "Num Detections": 19750, + "Num Negative": 19678, + "Num Positive": 72, + "Positive %": 0.3646, + "Num Positive per mm^2": 32.93 + } +} \ No newline at end of file diff --git a/703/TumorCenter_CD3_block12_x6_y10_patient703_1.json b/703/TumorCenter_CD3_block12_x6_y10_patient703_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c20896de152cf567faf156acbe24c0750cf67c63 --- /dev/null +++ b/703/TumorCenter_CD3_block12_x6_y10_patient703_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17840.6, + "Centroid Y µm": 25111.7, + "Num Detections": 18347, + "Num Negative": 18159, + "Num Positive": 188, + "Positive %": 1.025, + "Num Positive per mm^2": 88.52 + } +} \ No newline at end of file diff --git a/703/TumorCenter_CD8_block12_x5_y10_patient703_0.json b/703/TumorCenter_CD8_block12_x5_y10_patient703_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bbf81d7491e0edf4909e7c3400e3af8abef0e2f7 --- /dev/null +++ b/703/TumorCenter_CD8_block12_x5_y10_patient703_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 34531.7, + "Num Detections": 16106, + "Num Negative": 16086, + "Num Positive": 20, + "Positive %": 0.1242, + "Num Positive per mm^2": 9.8 + } +} \ No newline at end of file diff --git a/703/TumorCenter_CD8_block12_x6_y10_patient703_1.json b/703/TumorCenter_CD8_block12_x6_y10_patient703_1.json new file mode 100644 index 0000000000000000000000000000000000000000..35983c71757b2eea6280f82c425a6b91d8f049d3 --- /dev/null +++ b/703/TumorCenter_CD8_block12_x6_y10_patient703_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20764.0, + "Centroid Y µm": 34756.6, + "Num Detections": 14921, + "Num Negative": 14886, + "Num Positive": 35, + "Positive %": 0.2346, + "Num Positive per mm^2": 16.75 + } +} \ No newline at end of file diff --git a/703/history_text.txt b/703/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/703/icd_codes.txt b/703/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/703/ops_codes.txt b/703/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/703/patient_clinical_data.json b/703/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..90087a314d6dcc870347d1efdeb7a0f0c4bff999 --- /dev/null +++ b/703/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/703/patient_pathological_data.json b/703/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e131965b3d4fedfad9c69f2b5cc3cc10cb32159f --- /dev/null +++ b/703/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "703", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 17, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/703/surgery_description.txt b/703/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..70c8ff090c3d70c99afb39f387625be91d875b4f --- /dev/null +++ b/703/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, PEG placement, possibly Radial flap (according to the surgical protocol) diff --git a/703/surgery_report.txt b/703/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/704/InvasionFront_CD3_block8_x5_y5_patient704_0.json b/704/InvasionFront_CD3_block8_x5_y5_patient704_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d0700322c3f20df8c0d087acc22be9361cc06674 --- /dev/null +++ b/704/InvasionFront_CD3_block8_x5_y5_patient704_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 22663.0, + "Num Detections": 17310, + "Num Negative": 16864, + "Num Positive": 446, + "Positive %": 2.577, + "Num Positive per mm^2": 195.67 + } +} \ No newline at end of file diff --git a/704/InvasionFront_CD3_block8_x6_y5_patient704_1.json b/704/InvasionFront_CD3_block8_x6_y5_patient704_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ff452293a02a98fd58156d12f7c14385dc09d083 --- /dev/null +++ b/704/InvasionFront_CD3_block8_x6_y5_patient704_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 22588.0, + "Num Detections": 15152, + "Num Negative": 14829, + "Num Positive": 323, + "Positive %": 2.132, + "Num Positive per mm^2": 140.04 + } +} \ No newline at end of file diff --git a/704/InvasionFront_CD8_block8_x5_y5_patient704_0.json b/704/InvasionFront_CD8_block8_x5_y5_patient704_0.json new file mode 100644 index 0000000000000000000000000000000000000000..db3c0a5ee402fcbda0355c32becf9f41801f2d06 --- /dev/null +++ b/704/InvasionFront_CD8_block8_x5_y5_patient704_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16966.0, + "Centroid Y µm": 13043.1, + "Num Detections": 14509, + "Num Negative": 14230, + "Num Positive": 279, + "Positive %": 1.923, + "Num Positive per mm^2": 120.35 + } +} \ No newline at end of file diff --git a/704/InvasionFront_CD8_block8_x6_y5_patient704_1.json b/704/InvasionFront_CD8_block8_x6_y5_patient704_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f19d1b89c4deb21a24e3be55ac84c95412fe1c7e --- /dev/null +++ b/704/InvasionFront_CD8_block8_x6_y5_patient704_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19489.7, + "Centroid Y µm": 13243.0, + "Num Detections": 19552, + "Num Negative": 18876, + "Num Positive": 676, + "Positive %": 3.457, + "Num Positive per mm^2": 282.18 + } +} \ No newline at end of file diff --git a/704/TumorCenter_CD3_block8_x5_y5_patient704_0.json b/704/TumorCenter_CD3_block8_x5_y5_patient704_0.json new file mode 100644 index 0000000000000000000000000000000000000000..80c8a840df21e56dc90352e72c82154c20a4537f --- /dev/null +++ b/704/TumorCenter_CD3_block8_x5_y5_patient704_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 12568.3, + "Num Detections": 13368, + "Num Negative": 13026, + "Num Positive": 342, + "Positive %": 2.558, + "Num Positive per mm^2": 177.56 + } +} \ No newline at end of file diff --git a/704/TumorCenter_CD3_block8_x6_y5_patient704_1.json b/704/TumorCenter_CD3_block8_x6_y5_patient704_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b610a7b9e9eaced7feb682773ea78cdfc1c35409 --- /dev/null +++ b/704/TumorCenter_CD3_block8_x6_y5_patient704_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 12268.5, + "Num Detections": 13845, + "Num Negative": 13653, + "Num Positive": 192, + "Positive %": 1.387, + "Num Positive per mm^2": 99.91 + } +} \ No newline at end of file diff --git a/704/TumorCenter_CD8_block8_x5_y5_patient704_0.json b/704/TumorCenter_CD8_block8_x5_y5_patient704_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6f3ad1ba9ae6e53cbdde1bf02e82768cbd97d25 --- /dev/null +++ b/704/TumorCenter_CD8_block8_x5_y5_patient704_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16716.1, + "Centroid Y µm": 12718.3, + "Num Detections": 17446, + "Num Negative": 17313, + "Num Positive": 133, + "Positive %": 0.7624, + "Num Positive per mm^2": 62.56 + } +} \ No newline at end of file diff --git a/704/TumorCenter_CD8_block8_x6_y5_patient704_1.json b/704/TumorCenter_CD8_block8_x6_y5_patient704_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8ab50230a7031e28672816c5d1f4d0f12fda00ae --- /dev/null +++ b/704/TumorCenter_CD8_block8_x6_y5_patient704_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 12518.4, + "Num Detections": 17883, + "Num Negative": 17816, + "Num Positive": 67, + "Positive %": 0.3747, + "Num Positive per mm^2": 32.5 + } +} \ No newline at end of file diff --git a/704/history_text.txt b/704/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/704/icd_codes.txt b/704/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/704/ops_codes.txt b/704/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/704/patient_clinical_data.json b/704/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c4fda3d4c1ec8766f320e459869e743cd71eebaf --- /dev/null +++ b/704/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/704/patient_pathological_data.json b/704/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ccf935f5028c4f23a5a190a03f186ce89e3e2e58 --- /dev/null +++ b/704/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "704", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 33.0, + "number_of_resected_lymph_nodes": 17, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/704/surgery_description.txt b/704/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0be66eb6cd81c92f6e20247419ab2e1b7f55c974 --- /dev/null +++ b/704/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/704/surgery_report.txt b/704/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/705/InvasionFront_CD3_block22_x1_y12_patient705_0.json b/705/InvasionFront_CD3_block22_x1_y12_patient705_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5877a77712d01a6262d23603c9cbf03f34d81aed --- /dev/null +++ b/705/InvasionFront_CD3_block22_x1_y12_patient705_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4197.8, + "Centroid Y µm": 41178.2, + "Num Detections": 10341, + "Num Negative": 9593, + "Num Positive": 748, + "Positive %": 7.233, + "Num Positive per mm^2": 677.76 + } +} \ No newline at end of file diff --git a/705/InvasionFront_CD3_block22_x2_y12_patient705_1.json b/705/InvasionFront_CD3_block22_x2_y12_patient705_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f593cc93a5479e2dc2d846bf6035e3b74eaf3691 --- /dev/null +++ b/705/InvasionFront_CD3_block22_x2_y12_patient705_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6621.5, + "Centroid Y µm": 41428.1, + "Num Detections": 9659, + "Num Negative": 9095, + "Num Positive": 564, + "Positive %": 5.839, + "Num Positive per mm^2": 458.69 + } +} \ No newline at end of file diff --git a/705/InvasionFront_CD8_block22_x1_y12_patient705_0.json b/705/InvasionFront_CD8_block22_x1_y12_patient705_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f2df7b338f27fb97df261853cebdea7d132130c --- /dev/null +++ b/705/InvasionFront_CD8_block22_x1_y12_patient705_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7254.5, + "Centroid Y µm": 29517.6, + "Num Detections": 21318, + "Num Negative": 20841, + "Num Positive": 477, + "Positive %": 2.238, + "Num Positive per mm^2": 201.52 + } +} \ No newline at end of file diff --git a/705/InvasionFront_CD8_block22_x2_y12_patient705_1.json b/705/InvasionFront_CD8_block22_x2_y12_patient705_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c498d35236245ef76185ef12b2c16c826a5d0c8a --- /dev/null +++ b/705/InvasionFront_CD8_block22_x2_y12_patient705_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9771.7, + "Centroid Y µm": 29369.8, + "Num Detections": 14644, + "Num Negative": 14270, + "Num Positive": 374, + "Positive %": 2.554, + "Num Positive per mm^2": 233.3 + } +} \ No newline at end of file diff --git a/705/TumorCenter_CD3_block22_x1_y12_patient705_0.json b/705/TumorCenter_CD3_block22_x1_y12_patient705_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fa0530964441b259e30a81699d833d4d53cecaee --- /dev/null +++ b/705/TumorCenter_CD3_block22_x1_y12_patient705_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3698.0, + "Centroid Y µm": 29759.2, + "Num Detections": 15801, + "Num Negative": 13816, + "Num Positive": 1985, + "Positive %": 12.56, + "Num Positive per mm^2": 871.63 + } +} \ No newline at end of file diff --git a/705/TumorCenter_CD3_block22_x2_y12_patient705_1.json b/705/TumorCenter_CD3_block22_x2_y12_patient705_1.json new file mode 100644 index 0000000000000000000000000000000000000000..95866f92d8c1c55016dba286c2640c096975e914 --- /dev/null +++ b/705/TumorCenter_CD3_block22_x2_y12_patient705_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6021.8, + "Centroid Y µm": 29784.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/705/TumorCenter_CD8_block22_x1_y12_patient705_0.json b/705/TumorCenter_CD8_block22_x1_y12_patient705_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9ff2f23ed9d109479000220415b428878c6fc795 --- /dev/null +++ b/705/TumorCenter_CD8_block22_x1_y12_patient705_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5547.1, + "Centroid Y µm": 39454.1, + "Num Detections": 19479, + "Num Negative": 18791, + "Num Positive": 688, + "Positive %": 3.532, + "Num Positive per mm^2": 311.46 + } +} \ No newline at end of file diff --git a/705/TumorCenter_CD8_block22_x2_y12_patient705_1.json b/705/TumorCenter_CD8_block22_x2_y12_patient705_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0a8191ce414554781f207f9d9ca41130be502193 --- /dev/null +++ b/705/TumorCenter_CD8_block22_x2_y12_patient705_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8170.7, + "Centroid Y µm": 39704.0, + "Num Detections": 8513, + "Num Negative": 8487, + "Num Positive": 26, + "Positive %": 0.3054, + "Num Positive per mm^2": 30.6 + } +} \ No newline at end of file diff --git a/705/history_text.txt b/705/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d737e8bf104f1db19d42580b59cf85888ff4e856 --- /dev/null +++ b/705/history_text.txt @@ -0,0 +1 @@ +Patient with a cT2 G1 confirmed glottic laryngeal carinoma on the right with infiltration of the right morgue sinus and markedly poor adjustability at the endoscopy that was performed. Thus indication for the above measures. \ No newline at end of file diff --git a/705/icd_codes.txt b/705/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d640ef013f9c3dbc48269d1122c85a48224483f --- /dev/null +++ b/705/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 R] \ No newline at end of file diff --git a/705/ops_codes.txt b/705/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8527f43a2277140dc0d8b433d184da3915441bb9 --- /dev/null +++ b/705/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/705/patient_clinical_data.json b/705/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e4da305217e0f1a3ae0d8d3659d356075f326327 --- /dev/null +++ b/705/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 82, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/705/patient_pathological_data.json b/705/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..55e9787a1ae84ba8084151abe78ef0340c29ed05 --- /dev/null +++ b/705/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "705", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 2, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/705/surgery_description.txt b/705/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1eedf4f219ebbde593b623161e0157632d50e92 --- /dev/null +++ b/705/surgery_description.txt @@ -0,0 +1 @@ +Frontolateral partial laryngeal resection, Laryngoscopy diff --git a/705/surgery_report.txt b/705/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..01eec2cd81486c86b52e3b3f7f6210c211c937d1 --- /dev/null +++ b/705/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia and transoral endotracheal intubation by anesthesia colleagues and positioning of the patient by the surgeon. Initial insertion using a Kleinsasser tube, confirmation of the poor adjustability of the findings. Decision to proceed with fronto-lateral partial laryngectomy. Application of local anesthesia in a skin fold directly below the thyroid incisura. Skin ablation and sterile draping. Skin incision. Separation of the subcutaneous tissue and the platysma. Formation of a subplatysmal flap cranially and caudally. Exposure and transection of the prelaryngeal musculature in the midline from caudal to cranial. Exposure of the cricothyroid membrane and the ligamentum conicum and thyroid cartilage. Horizontal transection of the cricothyroid membrane in its midline. Subsequent median thyrotomy using a saw. Opening of the lumen of the glottis and supraglottis by mucosal incision and inspection of the findings. The two anterior thirds of the right vocal fold and the right morgue sinus were found to be completely affected by tumor, so the findings were resected using scissors. The specimen is thread-marked for final histology short short anterior commissure, short long supraglottis. Hemostasis by means of bipolar coagulation. 3 marginal samples were taken (right supraglottis, right subglottis, right arytenoid cartilage), all 3 were found to be tumor-free by the pathology colleague . Repeated inspection. Dryness prevails. Insertion of a Keel 16 mm, resulting in complete closure of the thyroid cartilage. Suture adaptation of the cricothyroid membrane and the ligamentum conicum. Suture adaptation of the prelaryngeal musculature in the midline. Creation of a flap. Platysma suture. Skin suture. Pressure bandage, completion of the procedure without complications. Please continue the intraoperatively initiated antibiotic treatment with Clindamycin 600 4 x daily for the next 7 days. Please plan control MLE and Keel removal in 8-12 weeks. \ No newline at end of file diff --git a/706/InvasionFront_CD3_block1_x5_y10_patient706_0.json b/706/InvasionFront_CD3_block1_x5_y10_patient706_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3619007a8aadd6d6e7d9eecbc696dfb5a2ef7cfd --- /dev/null +++ b/706/InvasionFront_CD3_block1_x5_y10_patient706_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 27035.7, + "Num Detections": 27966, + "Num Negative": 26868, + "Num Positive": 1098, + "Positive %": 3.926, + "Num Positive per mm^2": 379.06 + } +} \ No newline at end of file diff --git a/706/InvasionFront_CD3_block1_x6_y10_patient706_1.json b/706/InvasionFront_CD3_block1_x6_y10_patient706_1.json new file mode 100644 index 0000000000000000000000000000000000000000..75a670334a5675efdb5d3d7bcadc41544e93b15c --- /dev/null +++ b/706/InvasionFront_CD3_block1_x6_y10_patient706_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18640.1, + "Centroid Y µm": 27110.6, + "Num Detections": 25518, + "Num Negative": 25032, + "Num Positive": 486, + "Positive %": 1.905, + "Num Positive per mm^2": 171.68 + } +} \ No newline at end of file diff --git a/706/InvasionFront_CD8_block1_x5_y10_patient706_0.json b/706/InvasionFront_CD8_block1_x5_y10_patient706_0.json new file mode 100644 index 0000000000000000000000000000000000000000..43e7825868884d943fbfe1542e6e15a5baa205a0 --- /dev/null +++ b/706/InvasionFront_CD8_block1_x5_y10_patient706_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16111.6, + "Centroid Y µm": 25464.7, + "Num Detections": 27502, + "Num Negative": 22497, + "Num Positive": 5005, + "Positive %": 18.2, + "Num Positive per mm^2": 1719.8 + } +} \ No newline at end of file diff --git a/706/InvasionFront_CD8_block1_x6_y10_patient706_1.json b/706/InvasionFront_CD8_block1_x6_y10_patient706_1.json new file mode 100644 index 0000000000000000000000000000000000000000..039f99d4ee2f63474ab95227eb0b35db490d7ab7 --- /dev/null +++ b/706/InvasionFront_CD8_block1_x6_y10_patient706_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 25586.5, + "Num Detections": 25117, + "Num Negative": 21319, + "Num Positive": 3798, + "Positive %": 15.12, + "Num Positive per mm^2": 1341.2 + } +} \ No newline at end of file diff --git a/706/TumorCenter_CD3_block1_x5_y12_patient706_0.json b/706/TumorCenter_CD3_block1_x5_y12_patient706_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d5f6728132cf9e4285cdc45f168abf403d47939 --- /dev/null +++ b/706/TumorCenter_CD3_block1_x5_y12_patient706_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 29734.3, + "Num Detections": 16810, + "Num Negative": 13577, + "Num Positive": 3233, + "Positive %": 19.23, + "Num Positive per mm^2": 1532.4 + } +} \ No newline at end of file diff --git a/706/TumorCenter_CD3_block1_x6_y12_patient706_1.json b/706/TumorCenter_CD3_block1_x6_y12_patient706_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4728cfa048a2601e881ba90aaae1acb0f78b8779 --- /dev/null +++ b/706/TumorCenter_CD3_block1_x6_y12_patient706_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 29559.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/706/TumorCenter_CD8_block1_x5_y10_patient706_0.json b/706/TumorCenter_CD8_block1_x5_y10_patient706_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b228aa4048a8781796d5e1fdecae5f316064ec3 --- /dev/null +++ b/706/TumorCenter_CD8_block1_x5_y10_patient706_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 33707.2, + "Num Detections": 27144, + "Num Negative": 23913, + "Num Positive": 3231, + "Positive %": 11.9, + "Num Positive per mm^2": 1183.4 + } +} \ No newline at end of file diff --git a/706/TumorCenter_CD8_block1_x6_y10_patient706_1.json b/706/TumorCenter_CD8_block1_x6_y10_patient706_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c029564d2e0cf7478afc13d7a7f062bb4aa93ea9 --- /dev/null +++ b/706/TumorCenter_CD8_block1_x6_y10_patient706_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21563.6, + "Centroid Y µm": 33732.1, + "Num Detections": 21239, + "Num Negative": 18730, + "Num Positive": 2509, + "Positive %": 11.81, + "Num Positive per mm^2": 991.13 + } +} \ No newline at end of file diff --git a/706/history_text.txt b/706/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d8f2ad17e1646150cc556deba7efa59c256e4607 --- /dev/null +++ b/706/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma in the area of the base of the tongue extending to the lateral pharyngeal wall. Previous endoscopy described as cT1 findings. Now again, before planned transoral or laser resection, pharyngoscopy and laryngoscopy: The relatively small exophytic tumor at the lateral base of the tongue on the right side extending to the lateral pharyngeal wall is seen. However, there are now also changes in the area of the lower tonsil pole and in the direction of the hypopharynx, which are suspicious. Overall, however, macroscopically rather small findings. Due to the somewhat more extensive findings after the initial endoscopy, the tumor was now resected with a larger safety margin. \ No newline at end of file diff --git a/706/icd_codes.txt b/706/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/706/ops_codes.txt b/706/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bbde47a68855fce5a32794e2fe3b00b66fc69b59 --- /dev/null +++ b/706/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie endoskopische Laserresektion[5-302.5 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Exzision Tonsillentumor[5-289.x ] Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/706/patient_clinical_data.json b/706/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2ee3edc53ff610feaf9b8e8fd7022c0b1797b26b --- /dev/null +++ b/706/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 50, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/706/patient_pathological_data.json b/706/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a9cf290efea3e2745171caf839574451c622c192 --- /dev/null +++ b/706/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "706", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 28, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/706/surgery_description.txt b/706/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d054d2027600044bbb93d8b4521bd3bed134602 --- /dev/null +++ b/706/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Tracheostomy creation, Bilateral neck dissection diff --git a/706/surgery_report.txt b/706/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7e47c01aebd7bb774c9ae6d617e9a4510d634d34 --- /dev/null +++ b/706/surgery_report.txt @@ -0,0 +1 @@ +First insert the McIVOR spatula. The tongue and the base of the tongue can be visualized well here, as can the tonsil region and the transition to the alveolar ridge. Cut around the tumor macroscopically with a safety margin of at least 1-1.5 cm on all sides. The tonsil is removed in its entirety. Resection extends over the lateral area of the glossotonsillar or glossoalveolar junction into the base of the tongue. A slightly deeper resection is performed in the base of the tongue if the main tumor is present. The base of the tongue is removed up to the vallecula and the border of the epiglottis or up to the beginning of the hypopharynx. The entire specimen is thread-marked. Due to the somewhat smaller macroscopic distances in the area of the vallecula, base of the tongue and epiglottis, a further marginal sample is taken here, which extends over the base of the tongue, the vallecula to the epiglottis and to the edge of the transition to the hypopharynx. The frozen section still shows in-situ infiltrates caudally at the transition to the hypopharynx and in the area of the caudal tongue base, vallecula and epiglottis. For this reason, another extensive resection is performed with the laser in the hypopharyngeal region: After the tumor has been adjusted, a large, at least 1-1.5 cm wide resected hypopharyngeal mucosa is removed with a 5 watt continuous wave superpulse. A marginal sample is then taken from the entire hypopharyngeal area up to the edge of the larynx or epiglottis. The entire mucosa of the lingual epiglottis up to the edge of the epiglottis is removed from the vallecula area up to the lateral border of the epiglottis. Another strip of mucosa is removed from the vallecula-epiglottis area as a marginal sample, whereby mucosa is now also removed from the front of the epiglottis. The mucosal resection again extends medially to the beginning of the hypopharyngeal inlet. Then, after insertion of the FK blocker, a superficial strip of the entire medially resected tongue base up to the vallecula is obtained as a post-resectate and then another strip as a marginal sample. All three marginal samples are sent in. No more tomorin infiltrates here, so now R0 resection. Overall relatively extensive tumor, but mostly growing superficially. Neck dissection can therefore be performed. Neck dissection is now performed on the right side: skin incision in typical manner. Exposure of the sternocleidomastoid muscle, omohyoid muscle and digastric muscle. Exposure of the cervical vascular sheath. Depiction of the internal jugular vein, internal/external carotid artery. Exposure of the vagus nerve, hypoglossal nerve and accessorius nerve. Removal of the lymph nodes from levels II to V, preserving the branches of the cervical plexus. Several conspicuous lymph nodes are visible, especially in level II. Dissection somewhat more difficult due to the previous operation in which a lymph node extirpation was performed. Neck dissection on the left side: Here, an arched skin incision starting from the mastoid at the anterior edge of the sternocleidomastoid and bending posteriorly. Exposure of the cervical fascia. Creation of a platysmal flap. Exposure of the anterior margin of the sternocleidomastoid. Dissection in depth. Exposure of the omohyoid muscle. Exposure of the submandibular gland. Now dissect in the direction of the digaster muscle. Trace the digaster muscle cranially. The facial vein is exposed here. Trace the facial vein caudally. Expose the internal jugular vein and the cervical vascular sheath. Now successively detach the anterior triangle, which goes to the final histology. Dissection up to the plexus branches. Now detachment of level II a, after exposure of the accessorius nerve. Break through the neck preparation under the nerve. Further dissection caudally. This exposes the hypoglossal nerve. Successive detachment of the neck preparation in levels II a and III and IV. The preparation is sent for final histology. Irrigation with Wassertoff and Ringer. No evidence of further bleeding. Insertion of a 10 redon. Platys suture. Skin suturing and completion of the neck dissection. A tracheotomy was also performed during the operation after it became clear that the operation would be more extensive. Repositioning for tracheotomy. Palpation of the cricoid cartilage. 3 cm long skin incision at the level of the cricoid cartilage. Cut through the subcutaneous tissue. Exposure of the prelaryngeal musculature. This is split in the middle. Exposure of the anterior surface of the thyroid gland. Tunneling of the thyroid gland on the trachea from the cricoid cartilage caudally. Bipolar coagulation of the thyroid gland and transection of the thyroid isthmus. Exposure of the trachea. Incision between the second and third cartilage clasps with the 15 mm scalpel. Widen the incision so that a sufficiently large tracheotomy is created. Now suture caudally and cranially. The lateral skin ends are closed with skin sutures. Insertion of an LE tube without complications. PEG insertion is necessary if the resection is extended. However, the patient underwent intestinal surgery with insertion of a Vicryl mesh alio loco. The scar extends into the upper abdomen. Mesh insertion was probably also palpated here. Therefore, despite the possibility of diaphanoscopy, a PEG was not inserted. This should be performed by colleagues in internal medicine or surgery. A transnasal feeding tube was inserted for nutrition. The procedure was completed without complications. The patient was admitted to the intensive care unit for postoperative monitoring. Overall extensive tumor, which had only grown superficially in situ. In any case, N2b status on the right. Please continue postoperative antibiotics for one week. Feeding via feeding tube or PEG for approx. 7-8 days, then, depending on swallowing function, cautious diet build-up. Discussion of further procedure in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/707/InvasionFront_CD3_block4_x3_y1_patient707_0.json b/707/InvasionFront_CD3_block4_x3_y1_patient707_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0bcf47a2327c9732464be97641bcd0886b896882 --- /dev/null +++ b/707/InvasionFront_CD3_block4_x3_y1_patient707_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 9345.1, + "Num Detections": 18106, + "Num Negative": 17333, + "Num Positive": 773, + "Positive %": 4.269, + "Num Positive per mm^2": 354.55 + } +} \ No newline at end of file diff --git a/707/InvasionFront_CD3_block4_x4_y1_patient707_1.json b/707/InvasionFront_CD3_block4_x4_y1_patient707_1.json new file mode 100644 index 0000000000000000000000000000000000000000..13c6863366c0841cd031e9db1a59ae2ba3b8bf13 --- /dev/null +++ b/707/InvasionFront_CD3_block4_x4_y1_patient707_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16741.1, + "Centroid Y µm": 9170.1, + "Num Detections": 20218, + "Num Negative": 19715, + "Num Positive": 503, + "Positive %": 2.488, + "Num Positive per mm^2": 213.3 + } +} \ No newline at end of file diff --git a/707/InvasionFront_CD8_block4_x3_y1_patient707_0.json b/707/InvasionFront_CD8_block4_x3_y1_patient707_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6dbb820bed31272c158f90981f0d21bd5e4385d --- /dev/null +++ b/707/InvasionFront_CD8_block4_x3_y1_patient707_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11618.8, + "Centroid Y µm": 7546.0, + "Num Detections": 18684, + "Num Negative": 17837, + "Num Positive": 847, + "Positive %": 4.533, + "Num Positive per mm^2": 378.21 + } +} \ No newline at end of file diff --git a/707/InvasionFront_CD8_block4_x4_y1_patient707_1.json b/707/InvasionFront_CD8_block4_x4_y1_patient707_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7da1c6fc5bc5e420bca17c105c4d2fdb6b0bfd96 --- /dev/null +++ b/707/InvasionFront_CD8_block4_x4_y1_patient707_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 7571.0, + "Num Detections": 18020, + "Num Negative": 17300, + "Num Positive": 720, + "Positive %": 3.996, + "Num Positive per mm^2": 341.89 + } +} \ No newline at end of file diff --git a/707/TumorCenter_CD3_block4_x3_y1_patient707_0.json b/707/TumorCenter_CD3_block4_x3_y1_patient707_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c3d47c6f1937c804d6e94e8d4d12191923e86484 --- /dev/null +++ b/707/TumorCenter_CD3_block4_x3_y1_patient707_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 2673.6, + "Num Detections": 19040, + "Num Negative": 18872, + "Num Positive": 168, + "Positive %": 0.8824, + "Num Positive per mm^2": 76.25 + } +} \ No newline at end of file diff --git a/707/TumorCenter_CD3_block4_x4_y1_patient707_1.json b/707/TumorCenter_CD3_block4_x4_y1_patient707_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1599a81976dce79a2414830969125cecb5683c23 --- /dev/null +++ b/707/TumorCenter_CD3_block4_x4_y1_patient707_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 2698.6, + "Num Detections": 17956, + "Num Negative": 17495, + "Num Positive": 461, + "Positive %": 2.567, + "Num Positive per mm^2": 202.33 + } +} \ No newline at end of file diff --git a/707/TumorCenter_CD8_block4_x3_y1_patient707_0.json b/707/TumorCenter_CD8_block4_x3_y1_patient707_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0520f9d3d8cd0c1d77472b052d6896fa71682b4 --- /dev/null +++ b/707/TumorCenter_CD8_block4_x3_y1_patient707_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12468.4, + "Centroid Y µm": 2573.6, + "Num Detections": 19841, + "Num Negative": 19586, + "Num Positive": 255, + "Positive %": 1.285, + "Num Positive per mm^2": 116.83 + } +} \ No newline at end of file diff --git a/707/TumorCenter_CD8_block4_x4_y1_patient707_1.json b/707/TumorCenter_CD8_block4_x4_y1_patient707_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c6635c776c4cdc5675e8ea491c7ba0e9e56c7968 --- /dev/null +++ b/707/TumorCenter_CD8_block4_x4_y1_patient707_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14992.1, + "Centroid Y µm": 2673.6, + "Num Detections": 18607, + "Num Negative": 18252, + "Num Positive": 355, + "Positive %": 1.908, + "Num Positive per mm^2": 156.42 + } +} \ No newline at end of file diff --git a/707/history_text.txt b/707/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/707/icd_codes.txt b/707/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/707/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/707/ops_codes.txt b/707/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..49600b00fa717517e98ceddd08a577a17c2cc911 --- /dev/null +++ b/707/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Transorale Tumortonsillektomie[5-281.2 ] Tonsillektomie [ohne Adenotomie] radikal durch Pharyngotomie[5-281.3 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Sonstige radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.x4 ] Einfache Laryngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.04 ] Permanente Tracheotomie[5-312.0 ] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Resektion und Ersatz [Interposition] Arterien Kopf und Hals extrakraniell A. carotis externa[5-383.03 L] Alloplastisches Transplantat[5-930.4 ] \ No newline at end of file diff --git a/707/patient_clinical_data.json b/707/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f821ede0ae2cbe5aafc7fff652aa2a5328eee29e --- /dev/null +++ b/707/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/707/patient_pathological_data.json b/707/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..257a1191ba5d9a5df66f0ca4cd5a5b73bf40ef2f --- /dev/null +++ b/707/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "707", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 65, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/707/surgery_description.txt b/707/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7f084cd48014be165ecf4a98e0bf31bb7750d95 --- /dev/null +++ b/707/surgery_description.txt @@ -0,0 +1 @@ +Resection, LE, Bilateral neck dissection Level IIa-Va, Defect coverage, Free flap (Radial), Tracheotomy diff --git a/707/surgery_report.txt b/707/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..80805677bbc05c60d6e6f8a9159be32f5b2d0204 --- /dev/null +++ b/707/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues transnasally. Entry with the Kleinsasser tube and inspection of the tumor. The tumor starts in the area of the soft palate, moves to the tonsillar lobe on the right side, then from the tonsillar lobe to the base of the tongue and into the vallecula, from the vallecula to the epiglottis and from the epiglottis to the pharyngo-epiglottic fold on both sides, but on the right more than on the left, from the pharyngo-epiglottic fold to the pocket fold, on the right more than on the left. Injection and sterile washing and covering. Start with transoral tumor resection in the area of the soft palate. The monopolar needle, bipolar forceps and scissors are used for this. The tumor is released in the area of the soft palate and the tonsil lobe as well as partially at the base of the tongue. This automatically leads to the soft tissues of the neck, then switch to the neck, as the transoral view is no longer available. Now expose the sternocleidomastoid muscle. Expose the cervical vascular sheath and continue the tumor resection via a pharyngotomy from the outside. The tumor is dislocated outwards using the pull-through technique and resected en bloc on the right side and on the left side, taking two thirds of the hyoid bone and taking the epiglottis, vallecula and partial pocket fold with it. This resulted in a very large defect. The entire supraglottis had to be removed, leaving just the arytenoids on both sides and the vocal fold region. Now joint consideration of the next steps with . Due to the extensive pharyngeal defect and the pending transplant, it does not make sense to preserve the rest of the larynx, as a pronounced permanent aspiration must be assumed. The vocal folds will also no longer be functional due to the narrow resection margins and the suturing to the graft. Hence the decision to remove the rest of the larynx and insert a Provox prosthesis. This is done in the usual way. Measurement of the defect 5 x 8 x 13 cm. The graft is configured in such a way that there is a bulge for the base of the tongue so that there is a sliding surface for tongue mobility later on. The graft is lifted from the forearm in the usual way using . Lifting of the radialis graft on the left forearm by and : Marking of the skin graft on the distal forearm in the presence of . S-shaped skin incision in the area of the proximal forearm up to the crook of the elbow and incision around the marked radialis graft. Visualization of the superficial venous system in the area of the S-shaped skin incision. A pronounced cephalic vein can be seen, which is traced and visualized from proximal to distal further to the radial flap edge. Dissection of the radial edge of the flap down to the deep forearm fascia and incision of this. Exposure of the external ramus of the radial nerve and protection of the nerve. Exposure of the brachioradialis radialis muscle. Ulnar skin incision down to the deep forearm fascia and incision of the fascia. Subfascial dissection leaving the peritendineum and perimysium intact. Distal skin incision and ligation of the superficial veins. Identification of the radial artery with the accompanying V. comitans. Blunt detachment from the vascular bed and clipping of the distal radial artery stump for approx. 5 minutes. A good perfusion signal is noted during this time. Then decide on distal pedicle transection and vessel ligation. Exposure of the extensor carpi radialis muscle. Dissection of the flap pedicle from the depth with constant hemostasis using vascular clips. The radial nerve can be spared well. Insertion of a retractor between the extensor carpi radialis and brachioradialis muscles. Vessel preparation up to the crook of the elbow. Insertion of and exposure of the confluence. Separation of the radial artery just before the interosseous artery. Separation of the venous vessels at the superficial and deep venous system. This is followed by removal of an equivalent piece of split skin from the right thigh by and . Incision of the split-thickness skin graft in the usual manner. Sterile wound dressing. Application of a dorsal forearm splint. There was always a good perfusion signal during the operation. Neck dissection on both sides parallel to flap elevation. Start on the right side. Free preparation of the sternocleidomastoid muscle, the omohyoid muscle and the submandibular gland. The digastric muscle has already been dissected for the tumor resection. The hypoglossal nerve, accessory nerve and plexus branches can be spared. The facial vein cannot be spared. Remove the neck specimen II a to V a en bloc. Then turn to the opposite side. Here too, visualization of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Exposure of the cervical vascular sheath, the accessorius nerve, the hypoglossal nerve and removal of the neck preparation II a to V a while sparing the plexus branches. The facial vein and another caudal vein branch from the internal jugular vein can be preserved here. Dissection and preparation of these two venous outlets and the superior thyroid artery for the flap connection. Suturing of the graft. To do this, start transorally in the area of the soft palate and the edge of the tongue as well as the alveolar ridge, then suture the rest of the graft transcervically. At the end, suture the anastomoses in the usual manner. Microsurgical insertion of two Redon drains and two-layer wound closure. Please continue antibiotics for at least 24 hours. Flap controls and presentation of the patient at the tumor conference after receipt of the histology. \ No newline at end of file diff --git a/708/InvasionFront_CD3_block11_x5_y11_patient708_0.json b/708/InvasionFront_CD3_block11_x5_y11_patient708_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b6f09c29883ab2e76c6732fe3e2495fbb30953c4 --- /dev/null +++ b/708/InvasionFront_CD3_block11_x5_y11_patient708_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 26311.1, + "Num Detections": 15603, + "Num Negative": 12993, + "Num Positive": 2610, + "Positive %": 16.73, + "Num Positive per mm^2": 1514.4 + } +} \ No newline at end of file diff --git a/708/InvasionFront_CD3_block11_x6_y11_patient708_1.json b/708/InvasionFront_CD3_block11_x6_y11_patient708_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e1728c7b6c1878e4067b932f741c287e24c1551e --- /dev/null +++ b/708/InvasionFront_CD3_block11_x6_y11_patient708_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 26261.1, + "Num Detections": 12154, + "Num Negative": 9415, + "Num Positive": 2739, + "Positive %": 22.54, + "Num Positive per mm^2": 1913.4 + } +} \ No newline at end of file diff --git a/708/InvasionFront_CD8_block11_x5_y11_patient708_0.json b/708/InvasionFront_CD8_block11_x5_y11_patient708_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9563607ea0204d0a5771dc2901a3133837d924ab --- /dev/null +++ b/708/InvasionFront_CD8_block11_x5_y11_patient708_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18620.3, + "Centroid Y µm": 37638.8, + "Num Detections": 11919, + "Num Negative": 11174, + "Num Positive": 745, + "Positive %": 6.251, + "Num Positive per mm^2": 593.43 + } +} \ No newline at end of file diff --git a/708/InvasionFront_CD8_block11_x6_y11_patient708_1.json b/708/InvasionFront_CD8_block11_x6_y11_patient708_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4466c20befc7c52a7367c1b8cdcf48d330198453 --- /dev/null +++ b/708/InvasionFront_CD8_block11_x6_y11_patient708_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21036.3, + "Centroid Y µm": 37820.6, + "Num Detections": 2944, + "Num Negative": 2897, + "Num Positive": 47, + "Positive %": 1.596, + "Num Positive per mm^2": 137.81 + } +} \ No newline at end of file diff --git a/708/TumorCenter_CD3_block11_x5_y11_patient708_0.json b/708/TumorCenter_CD3_block11_x5_y11_patient708_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6ef16e4a80537cffa8c074bfff7e9bf4c1d06639 --- /dev/null +++ b/708/TumorCenter_CD3_block11_x5_y11_patient708_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 27685.3, + "Num Detections": 18332, + "Num Negative": 15486, + "Num Positive": 2846, + "Positive %": 15.52, + "Num Positive per mm^2": 1334.3 + } +} \ No newline at end of file diff --git a/708/TumorCenter_CD3_block11_x6_y11_patient708_1.json b/708/TumorCenter_CD3_block11_x6_y11_patient708_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4b3a3b0de17e7b11d2bc451f0c37d1ac22aec886 --- /dev/null +++ b/708/TumorCenter_CD3_block11_x6_y11_patient708_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20864.0, + "Centroid Y µm": 27835.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/708/TumorCenter_CD8_block11_x5_y11_patient708_0.json b/708/TumorCenter_CD8_block11_x5_y11_patient708_0.json new file mode 100644 index 0000000000000000000000000000000000000000..92f96fe76e9601fd902158fcec4349494d84f7c2 --- /dev/null +++ b/708/TumorCenter_CD8_block11_x5_y11_patient708_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 27435.5, + "Num Detections": 19313, + "Num Negative": 17380, + "Num Positive": 1933, + "Positive %": 10.01, + "Num Positive per mm^2": 814.35 + } +} \ No newline at end of file diff --git a/708/TumorCenter_CD8_block11_x6_y11_patient708_1.json b/708/TumorCenter_CD8_block11_x6_y11_patient708_1.json new file mode 100644 index 0000000000000000000000000000000000000000..418aed627715c090b78e568e4bf065f704733b28 --- /dev/null +++ b/708/TumorCenter_CD8_block11_x6_y11_patient708_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18640.1, + "Centroid Y µm": 27410.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/708/history_text.txt b/708/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9f0d952b658536193966de53661d9dad30fe5836 --- /dev/null +++ b/708/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 cN0 G2 differentiated uvular carcinoma was histologically confirmed during a panendoscopy. The CT scan showed no evidence of distant metastasis. Extensive anesthesiologic/internal surgical preparation was performed in the presence of high-grade COPD and CHD. \ No newline at end of file diff --git a/708/icd_codes.txt b/708/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..38d76f9304569863d2ad996209bc4fcde6301d75 --- /dev/null +++ b/708/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Uvula[C05.2 ] \ No newline at end of file diff --git a/708/ops_codes.txt b/708/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6b8ae9b0aa4e4ea979a903ae3c7dd4b9f213619b --- /dev/null +++ b/708/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Exzision und Destruktion des (erkrankten) harten und weichen Gaumens: Exstirpation, total, transoral[5-272.2 ] Lappenplastik mit freiem Lappen mit mikrovaskulärer Anastomose Entnahmestelle Unterarm[5-904.08 L] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 R] Anlegen und Wechsel einer duodenalen oder jejunalen Ernährungssonde über eine liegende PEG-Sonde, endoskopisch[8-125.2 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 PEG-Sonde Anlage[5-431.2 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/708/patient_clinical_data.json b/708/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..101923b2cfbb9c67fd6f4f8fef5e342086bc5514 --- /dev/null +++ b/708/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 44, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/708/patient_pathological_data.json b/708/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..350396ab767fb77b493202f5fdea27b8563b6d54 --- /dev/null +++ b/708/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "708", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 48, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/708/surgery_description.txt b/708/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b04d382fb6ddc3dcb738008c2e4837c28cb95b00 --- /dev/null +++ b/708/surgery_description.txt @@ -0,0 +1 @@ +Anterior resection, Neck dissection, Free flap (Radial) diff --git a/708/surgery_report.txt b/708/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..40e08a497ea5f7a097866e5a70c34a91079479a1 --- /dev/null +++ b/708/surgery_report.txt @@ -0,0 +1 @@ +First of all, the PEG was inserted. Entry with the gastroscope under laryngoscopic control, easy visualization up to the stomach, which is inconspicuous and free. There is median scarring from the arteriocoronary bypasses performed and a scar in the lower abdomen, no other known gastric or intestinal interventions. Therefore, with excellent diaphanoscopy, problem-free puncture of the stomach and placement of the PEG using the usual suture pull-through method. Subsequent positioning of the patient, where an extensive contracture in the neck muscles as well as the shoulder-arm muscles is noticeable. Therefore, limited conditions here. First perform the tumor resection. Insertion of the tonsil plug. There is an exophytic mass of the soft palate relatively median. The uvula is completely consumed by the tumor. The mass measures a good 3 x 2 cm in the area of the soft palate and extends to the posterior palatal arch on both sides, no further deep infiltration on palpation. The extent is just cT2. Good differentiation from the surrounding mucosa. Resection is now carried out at a distance of approx. 1.5 cm in the area of the soft palate; in the transition to the posterior palatal arch, resection is carried out taking the tonsils with it. Dissection of the tonsils using the dissection technique on the right side with questionable infiltration of the upper tonsil pole, otherwise the tonsils are free with a regular capsule. Partial resection of the posterior palatal arch on both sides, vertical transection of the soft palate and removal of the tumor en bloc with subtotal soft palate resection and both tonsils with palatal arches. It can be seen that the tumor also spreads almost symmetrically to the posterior wall of the soft palate. Here too, a safety margin of approx. 1 cm can be maintained. The resectate is completely thread-marked for frozen section diagnostics and is assessed here as an R0 resected caricinoma. After meticulous hemostasis, a defect of both tonsillar lobes is seen, slightly larger on the right side. A subtotal soft palate defect was found. Therefore confirmation of the indication for defect coverage using a radialis graft. A graft measuring 10 x 5 cm and tailored to the soft palate reconstruction is measured. The neck dissection is now performed first. Start with the left side. As described above, the extensive contracture in the area of the sternocleidomastoid muscle can be seen. First, a curved skin incision on the anterior edge of the sternocleidomastoid muscle, very short neck overall. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Exposure and preservation of the external jugular vein and the auricularis magnus nerve. Exposure of the sternocleidomastoid muscle. Extensive contracture. Now explore the sternal part, here clearly contracted, tendinous tissue, partial severing of the attachment, but clear loosening. Exposure of the omohyoid muscle, exposure of the submandibular gland and the digastric muscle, removal of the anterior neck preparation with careful protection of the superior thyroid artery, the cervical artery and the hypoglossal nerve. Preservation and visualization of the V. facialis and free preparation of the V. jugularis interna. Identification and visualization of the accessorius nerve, evacuation of the accessorius triangle with careful protection of the nerve and evacuation of level 5 with careful protection of the cervical plexus branches. Palpation of level 1b. Final wound inspection and, if the wound is dry, wound irrigation with Ringer's solution and careful two-layer wound closure after insertion of a 10-gauge Redon drain. Overall, there was no clinical evidence of metastasis. Turning to the opposite side. In principle exactly the same procedure here. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Exposure and preservation of the external jugular vein and the auricular nerve. Exposure and dissection of the sternocleidomastoid muscle. Also in the case of extensive contracture. Release of the sternal insertion. Exposure of the omohyoid muscle, exposure of the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the superior thyroid artery, the facial vein, the hypoglossal nerve and the cervical sinus. A clear venous plexus with communication of the external jugular vein and two strong facial vein branches can be seen on this side in the area of the veins. ...... in the connection between the external jugular and facial veins. Otherwise preservation of the venous structures. Now free preparation of the internal jugular vein. Exposure of the accessorius nerve. Free dissection of the vein, evacuation of the accessorius triangle with careful protection of the nerve, evacuation of level 5 with careful protection of the cervical plexus branches. Evacuation of level 1b, no suspicious conditions here. The digastric muscle is now resected. Exposure of the carotid artery, exposure of the bulb and the external and internal splitting. Along the carotid artery towards the tonsillar ligament, here blunt opening of the tonsillar ligament. Combined transoral and transcervical widening of the access up to a width of 2 QF. Finally, good conditions. Minutious hemostasis, careful protection of the hypoglossal nerve, which is located at the lower edge of the pharyngotomy. Now turn to the graft elevation. The preoperative examination revealed a moderate vascular situation in the area of the forearm, negative elliptical test, but unclear Doppler sonographic conditions, therefore the graft was lifted without blood emptying. Radial marking of the graft. First incise the radial artery, cut through the skin and subcutaneous tissue. Expose the cephalic vein. This is not lifted if the superficial venous network is irregular. Perform the Haydn maneuver. Expose and protect the superficial radial nerve ramus. This is very weak here, the pulse is barely palpable. After isolating the vascular pedicle, the vascular pedicle is now clamped with the bulldog clamp. No changes in the area of the blood supply to the hand. Further dissection. Exposure of the brachioradilaris muscle. Exposure of the flexor carpi ulnaris. Strictly subfascial preparation. The proximal radial artery is now explored again. Here, a larger caliber, complete cutting of the graft and isolation on the vascular pedicle. The blood supply to the graft is normal, so the distal vascular pedicle is ligated while the blood supply to the hand is also excellent and unchanged. Subfascial release of the graft, isolation on the vascular pedicle. Clipping and ligation of distal vein branches. There is a strong connection of the accompanying veins to the superficial venous system. Capping to the deep venous system. Isolation of the radial artery after visualization of the ulnar artery. It can be seen that there is little pulsation in the area of the vascular pedicle. Good pulsation proximally. After initially slight vascular spasm, which is completely resolved by applying heat, the graft is removed with normal vitality. Meticulous hemostasis and, if the wound in the forearm area is dry, careful two-layer wound closure and insertion of the full-thickness skin graft from the groin. Finally, application of a vacuum sealant dressing and application of the stretcher splint in the functional site. To lift the full-thickness skin graft from the groin, measure the required skin defect and trim the skin. Strictly cutaneous preparation, subcutaneous mobilization. Meticulous hemostasis. Insertion of a 10-gauge Redon drain and careful, strong two-layer wound closure under good tensioning conditions. The graft is now inserted from transcervical to transoral. The soft palate is reconstructed with a good fit, good reconstruction of the tonsillar lobes and cervical pedicle positioning with tight conditions on all sides and sufficient soft palate reconstruction. Conditioning of the vessels. 2 strong superficial veins were lifted in the area of the radialis graft. Conditioning of the artery. The superior thyroid artery is now prepared if the positional relationship is good. If the arterial pressure conditions are good, clip the distal vascular pedicle. Shorten the superior thyroid artery until a tolerable caliber equivalence is achieved. Slight caliber advantage in the area of the radial artery. Now carefully suture the vessel and adapt the caliber with 8 .................... and Ethilon. This works well. After reopening the Acland clamps, immediate tightness and good venous return with regular flap vitality. One flap vein is now clearly leading in the area of venous return. Therefore clipping of the 2nd vein. Conditioning of the deep facial venous branch. Measurement of a coupler size 3.5. Easy guidance of the venous anastomosis with the coupler. Subsequent good venous reperfusion and reopening of the artery. Regular flap vitality with intact and stable conditions and good pedicle positioning. After final wound inspection under dry conditions, a 10-gauge Redon drain is inserted caudally. This is separated from the anastomosis with a muscle adaptation suture and finally careful two-layer wound closure with multiple inspections of the regular graft. In the meantime, a plastic tracheostomy was performed. For this, a skin incision was made approximately at the level of the cricoid cartilage with the larynx very low. The cricoid cartilage can at best be palpated through the skin. Cut through the skin and subcutaneous tissue. Exposure of the ethmoidal musculature. Dissection of the musculature. Exposure of the cricoid cartilage. Extremely difficult dissection conditions here with deep cricoid cartilage. Exposure of the cricoid cartilage. Exposure of the strong thyroid isthmus. Dissection of the thyroid isthmus after puncture ligation in the sense of a tobacco pouch suture. Exposure of the anterior surface of the trachea. Here too, the conditions are much more difficult. Insertion between the 1st and 2nd tracheal ring. Attempt to create a Björk flap. Clearly porous cartilage conditions in the area of the trachea. Laborious insertion of the tracheostoma with repeatedly difficult adaptation conditions. Finally, stable tracheostoma and, at the end of the operation, problem-free reintubation to an 8 mm low cuff cannula. Suturing of the cannula and, on final inspection, regular flap vitality and completion of the procedure at this point without any indication of complications. Conclusion: Intraoperative R0 resected cT2 cN0 G2 uvular carcinoma. Tracheotomy was already performed preoperatively on pulmonological recommendation for the best possible weaning prerequisite in case of possible problems with severe COPD. Meticulous flap monitoring postoperatively. After regular weaning, the gradual build-up of the diet can begin on the 8th postoperative day if the enoral conditions are intact. If swallowing function is normal, prompt decannulation depending on the pulmonary situation. \ No newline at end of file diff --git a/709/InvasionFront_CD3_block15_x1_y4_patient709_0.json b/709/InvasionFront_CD3_block15_x1_y4_patient709_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c80f3cd72b1853207481900b40bc8dcf5c41e025 --- /dev/null +++ b/709/InvasionFront_CD3_block15_x1_y4_patient709_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5622.0, + "Centroid Y µm": 20539.1, + "Num Detections": 20962, + "Num Negative": 19817, + "Num Positive": 1145, + "Positive %": 5.462, + "Num Positive per mm^2": 475.62 + } +} \ No newline at end of file diff --git a/709/InvasionFront_CD3_block15_x2_y4_patient709_1.json b/709/InvasionFront_CD3_block15_x2_y4_patient709_1.json new file mode 100644 index 0000000000000000000000000000000000000000..33f1b04cbb136d03ab5b83596bc1a0185e84f90e --- /dev/null +++ b/709/InvasionFront_CD3_block15_x2_y4_patient709_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8195.7, + "Centroid Y µm": 20489.2, + "Num Detections": 14942, + "Num Negative": 14265, + "Num Positive": 677, + "Positive %": 4.531, + "Num Positive per mm^2": 334.59 + } +} \ No newline at end of file diff --git a/709/InvasionFront_CD8_block15_x1_y4_patient709_0.json b/709/InvasionFront_CD8_block15_x1_y4_patient709_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b6eccf52ee4c851a4ba552446185b60e51fc14da --- /dev/null +++ b/709/InvasionFront_CD8_block15_x1_y4_patient709_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.6, + "Centroid Y µm": 9965.8, + "Num Detections": 18893, + "Num Negative": 18526, + "Num Positive": 367, + "Positive %": 1.943, + "Num Positive per mm^2": 167.63 + } +} \ No newline at end of file diff --git a/709/InvasionFront_CD8_block15_x2_y4_patient709_1.json b/709/InvasionFront_CD8_block15_x2_y4_patient709_1.json new file mode 100644 index 0000000000000000000000000000000000000000..68dce1bdc27802c8a646463eab51cae2ad3ccf22 --- /dev/null +++ b/709/InvasionFront_CD8_block15_x2_y4_patient709_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6414.4, + "Centroid Y µm": 9856.9, + "Num Detections": 9949, + "Num Negative": 9499, + "Num Positive": 450, + "Positive %": 4.523, + "Num Positive per mm^2": 306.45 + } +} \ No newline at end of file diff --git a/709/TumorCenter_CD3_block15_x1_y4_patient709_0.json b/709/TumorCenter_CD3_block15_x1_y4_patient709_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a72bc1931b4ea4d3d88ebcd8fec6c458c65e1a10 --- /dev/null +++ b/709/TumorCenter_CD3_block15_x1_y4_patient709_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4022.9, + "Centroid Y µm": 13417.9, + "Num Detections": 20399, + "Num Negative": 19241, + "Num Positive": 1158, + "Positive %": 5.677, + "Num Positive per mm^2": 502.14 + } +} \ No newline at end of file diff --git a/709/TumorCenter_CD3_block15_x2_y4_patient709_1.json b/709/TumorCenter_CD3_block15_x2_y4_patient709_1.json new file mode 100644 index 0000000000000000000000000000000000000000..910a584e63fb3989c8ddb3f92c71d7c5e425542a --- /dev/null +++ b/709/TumorCenter_CD3_block15_x2_y4_patient709_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 13317.9, + "Num Detections": 20417, + "Num Negative": 18258, + "Num Positive": 2159, + "Positive %": 10.57, + "Num Positive per mm^2": 940.4 + } +} \ No newline at end of file diff --git a/709/TumorCenter_CD8_block15_x1_y4_patient709_0.json b/709/TumorCenter_CD8_block15_x1_y4_patient709_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9080b1eb599096674c13cb26f5583cdb8079bb00 --- /dev/null +++ b/709/TumorCenter_CD8_block15_x1_y4_patient709_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 10069.7, + "Num Detections": 19126, + "Num Negative": 18022, + "Num Positive": 1104, + "Positive %": 5.772, + "Num Positive per mm^2": 484.45 + } +} \ No newline at end of file diff --git a/709/TumorCenter_CD8_block15_x2_y4_patient709_1.json b/709/TumorCenter_CD8_block15_x2_y4_patient709_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf292a7d9123414e9f7e95773db440da875465c3 --- /dev/null +++ b/709/TumorCenter_CD8_block15_x2_y4_patient709_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9020.2, + "Centroid Y µm": 10019.7, + "Num Detections": 19177, + "Num Negative": 17601, + "Num Positive": 1576, + "Positive %": 8.218, + "Num Positive per mm^2": 694.57 + } +} \ No newline at end of file diff --git a/709/icd_codes.txt b/709/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b726963807f048843213f2656edbce103649d7e --- /dev/null +++ b/709/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zunge, nicht näher bezeichnet[C02.9 ] \ No newline at end of file diff --git a/709/ops_codes.txt b/709/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..784a6ffa24425ebdfd2473bded82e757b24d1524 --- /dev/null +++ b/709/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie: Transoral: Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.02 ] Partielle Glossektomie: Durch Pharyngotomie: Sonstige[5-251.2x ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 L] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 3 Regionen[5-403.02 R] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Anlage eines Systems zur Vakuumversiegelung an Haut und Unterhaut[5-916.a0 ] Kontinuierliche Sogbehandlung bei Vakuumversiegelung Bis 7 Tage[8-190.10 ] Transplantation sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.93 R] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 R] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] \ No newline at end of file diff --git a/709/patient_clinical_data.json b/709/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f77d7b5696dd8bcb94a0671f81a88ba3aabd065c --- /dev/null +++ b/709/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 77, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "palliative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/709/patient_pathological_data.json b/709/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e3af5415b3d96055fb9cff7d808b992561a2a700 --- /dev/null +++ b/709/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "709", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/710/InvasionFront_CD3_block6_x3_y3_patient710_0.json b/710/InvasionFront_CD3_block6_x3_y3_patient710_0.json new file mode 100644 index 0000000000000000000000000000000000000000..646a1ed67fd9a63747ab90f91abdb829122b0fc0 --- /dev/null +++ b/710/InvasionFront_CD3_block6_x3_y3_patient710_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12468.4, + "Centroid Y µm": 8020.8, + "Num Detections": 16040, + "Num Negative": 14746, + "Num Positive": 1294, + "Positive %": 8.067, + "Num Positive per mm^2": 600.92 + } +} \ No newline at end of file diff --git a/710/InvasionFront_CD3_block6_x4_y3_patient710_1.json b/710/InvasionFront_CD3_block6_x4_y3_patient710_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3fb6bab294fbbda4a549af56bdc0cecf94ae1e34 --- /dev/null +++ b/710/InvasionFront_CD3_block6_x4_y3_patient710_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15142.0, + "Centroid Y µm": 8220.6, + "Num Detections": 21190, + "Num Negative": 19502, + "Num Positive": 1688, + "Positive %": 7.966, + "Num Positive per mm^2": 660.06 + } +} \ No newline at end of file diff --git a/710/InvasionFront_CD8_block6_x3_y1_patient710_0.json b/710/InvasionFront_CD8_block6_x3_y1_patient710_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cbb68cd9f6cd979fd3cb7d7fc5285b773a101c0e --- /dev/null +++ b/710/InvasionFront_CD8_block6_x3_y1_patient710_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12993.1, + "Centroid Y µm": 2423.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/710/InvasionFront_CD8_block6_x4_y1_patient710_1.json b/710/InvasionFront_CD8_block6_x4_y1_patient710_1.json new file mode 100644 index 0000000000000000000000000000000000000000..337829d9bb7ff1ec5eb39f7331e61098f734e276 --- /dev/null +++ b/710/InvasionFront_CD8_block6_x4_y1_patient710_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15491.8, + "Centroid Y µm": 2573.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/710/TumorCenter_CD3_block6_x3_y1_patient710_0.json b/710/TumorCenter_CD3_block6_x3_y1_patient710_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f7f86db9a46752c0757f58344b5a66402863b7fa --- /dev/null +++ b/710/TumorCenter_CD3_block6_x3_y1_patient710_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 2798.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/710/TumorCenter_CD3_block6_x4_y1_patient710_1.json b/710/TumorCenter_CD3_block6_x4_y1_patient710_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d1e0872f083b4dd67718a5238947fae5a58bcb2 --- /dev/null +++ b/710/TumorCenter_CD3_block6_x4_y1_patient710_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 2773.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/710/TumorCenter_CD8_block6_x3_y1_patient710_0.json b/710/TumorCenter_CD8_block6_x3_y1_patient710_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9e972092a87abb312103aaa1e424e135d37eded6 --- /dev/null +++ b/710/TumorCenter_CD8_block6_x3_y1_patient710_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 2973.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/710/TumorCenter_CD8_block6_x4_y1_patient710_1.json b/710/TumorCenter_CD8_block6_x4_y1_patient710_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3df6613fb2670e24e0dcc6a128b618a5514ea4da --- /dev/null +++ b/710/TumorCenter_CD8_block6_x4_y1_patient710_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 2973.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/710/patient_clinical_data.json b/710/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..be2cbe7fdd87d5167f15a4a1b24663aeecec4396 --- /dev/null +++ b/710/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 49, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "carboplatin", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/711/InvasionFront_CD3_block19_x2_y10_patient711_1.json b/711/InvasionFront_CD3_block19_x2_y10_patient711_1.json new file mode 100644 index 0000000000000000000000000000000000000000..299094ec3e830372a287e82579c48820b6da4810 --- /dev/null +++ b/711/InvasionFront_CD3_block19_x2_y10_patient711_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 26785.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/711/TumorCenter_CD8_block19_x1_y10_patient711_0.json b/711/TumorCenter_CD8_block19_x1_y10_patient711_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6c65573b839198e06e99ec43a1c7bc91ed015532 --- /dev/null +++ b/711/TumorCenter_CD8_block19_x1_y10_patient711_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6717.8, + "Centroid Y µm": 36232.7, + "Num Detections": 16539, + "Num Negative": 16427, + "Num Positive": 112, + "Positive %": 0.6772, + "Num Positive per mm^2": 59.35 + } +} \ No newline at end of file