diff --git a/442/history_text.txt b/442/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4bcb6539c42b7be52436c52f700bc13d4041cca6 --- /dev/null +++ b/442/history_text.txt @@ -0,0 +1 @@ +Patient with post attempted enoral tumor resection with extended tonsillectomy. The final specimen shows R1 on all sides, therefore the above-mentioned operation with flap coverage of an expected defect is now planned. CT also shows extension of the tumor into the pharyngeal wall. \ No newline at end of file diff --git a/442/ops_codes.txt b/442/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0e98dcd26cf6e73283dfc93677f41625d8b43d2 --- /dev/null +++ b/442/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroduodenoskopie bei normalem Situs[1-632.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 L] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Temporäre Tracheotomie[5-311.0 ] Transplantat[5-295.14 ] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] \ No newline at end of file diff --git a/442/surgery_description.txt b/442/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7dcdaae3ba70cd1328294f266ffe52d15f29cd18 --- /dev/null +++ b/442/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection (Level II-IV bilaterally), Defect coverage (Radial), Tracheostomy, PEG placement diff --git a/442/surgery_report.txt b/442/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..79b35ac62a12191f37759b4d6e10d2c01d41501b --- /dev/null +++ b/442/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again, showing the fibrin-covered area where the tumor was resected. Tumor is visible in the direction of the hypopharynx. Confirmation of the indication. Initial PEG placement using the thread pull-through method. With very good diaphanoscopy, this is successful without any problems. Then skin disinfection of all relevant surgical areas and sterile draping. Then start with neck dissection on both sides: Neck dissection on the right (): Skin incision and dissection through the subcutaneous fatty tissue. Separation of the platysma and subplatysmal dissection. Exposure of the anterior border of the MSCM and identification and preservation of the accessory nerve. Tracing of the omohyoid muscle and visualization of the. Gl. submandibularis. Visualization of the posterior venter of the digastric muscle. A large metastasis is seen in region Ib/II, which is located directly on the internal jugular vein. Dissection of the VJI and careful dissection of the metastasis. Ligation of a large branch of the VJI in order to be able to use it later for the venous anastomosis. Ligation of the V. Facialis for the same reason, exposure and preservation of the ACI, ACC and ACE as well as the vagus nerve and the cervical artery. Exposure and preservation of the hypoglossal nerve. Now successive removal of the lateral and medial neck preparation, i.e. from region Ib to V while preserving the plexus branches. Dissection of the superior thyroid artery and the facial artery in order to be able to use them later for the microvascular anastomosis Neck dissection on the left: Sharp dissection of the skin, subcutaneous tissue and platysma. Exposure of the anterior border of the sternocleidomastoid muscle, the digaster muscle, the accessorius nerve and the omohyoid muscle. Exposure of the cervical vascular sheath with the internal jugular vein and facial vein, ACC, ACI, ACE, vagus nerve, cervical plexus and subsequent removal of the neck preparation from level II to IV without complications and with preservation of all the structures mentioned. Insertion of a Redon drain. Two-layer wound closure, first of the platysma and then of the skin. Subsequent combined transcervical, transoral tumor resection: First dissection of the large neck vessels from the pharyngeal tube. Small outgoing vessels are ligated or treated. Snaring of the internal carotid artery, external carotid artery and common carotid artery as well as snaring of the hypoglossal nerve. V. facialis is placed cranially. The lingual artery is ligated and double ligated in the direction of the external carotid artery. Pharyngeal tube is dissected free towards the base of the skull. Border cord is preserved. Subsequent resection of the tumor with a safety margin of at least 1.5 to 2 cm on all sides, whereby the entire pharyngeal wall is resected in each case. The uvula with soft and hard palate on the right, the entire tonsil lobe, the mucosa at the transition to the base of the tongue, a lateral part of the base of the tongue to the medial side and the posterior palatal arch of the medial pharyngeal wall are resected. The resection is then completed from the outside, whereby both parts of the base of the tongue, the vallecula, upper parts of the arytenoid fold and the medial and anterior as well as small parts of the lateral piriform sinus wall must also be resected. The tumor is marked using sutures. In addition, marginal samples are taken from the lateral pharyngeal wall caudal to the right of the piriform sinus, from the lateral right arytenoid area and from the medial arytenoid area to the edge of the epiglottis. In the frozen section, all marginal samples were tumor-free as well as the specimen. In the cranial area, a resection is recommended again for safety reasons, therefore a strip several mm in size is taken from the soft palate to hard palate area up to the lateral alveolar ridge, here a thread-marked specimen is taken and sent for frozen section. There were no tumor infiltrates either in the mucosa or in the soft tissue, not even in the additional soft tissue removed. So now R0 resection. Defect size is measured at 12 to 13 x 8 to 9 cm. Marking on the forearm according to the required three-dimensional configuration. Subsequent removal of the radial artery flap : skin incision and dissection through the subcutaneous fatty tissue. Locate and expose the cephalic vein and small venous anastomoses. Preparation of the pedicle between the brachioradialis muscle and the flexor carpi radialis muscle. Exposure of the venous star. Now successive further dissection of the pedicle and clipping of perforating vessels. Trimming of the 14x8cm graft. Ulnar subfascial dissection with identification and preservation of the ulnar artery and nerve. Now radial incision and radial dissection of the cephalic vein. Separation of several venous outlets by means of ligation. Separation of the cephalic vein distally. Locate the radial nerve R superficialis and preserve it. A small branch is pulled into the flap and removed. Careful further preparation of the remaining graft. After the R0 tumor has been resected, the graft is removed. Subsequent insertion of the radial flap into the defect and vascular suture: After the radial flap has been removed, rinse thoroughly with plenty of heparin. Insertion of the flap into the defect. Successive suturing of the flap with 3-0 Vicryl single-button sutures, partly with caudal and then cranial exposure. The flap fits very well into the defect and fulfills the three-dimensional requirement. The flap is then connected to the vessels. The superior thyroid artery is selected as the arterial vessel. After conditioning the vessels, suture with 9-0 Ethilon single-button sutures. Subsequent dissection of the V. thyroidea media and a branch of the V. facialis. The V. thyroidea media is anastomosed to the one outlet in the area of the V. cephalica using a 2.5 mm coupler after conditioning the vessels. Good venous return after opening the clips, positive smear phenomenon. The other outlet from the cephalic vein is then anastomosed with an outlet from the facial vein. Here too, after opening the clamps, the smear phenomenon is positive. Then clip all other available venous outlets. Careful hemostasis and irrigation. Wound closure in layers on both sides of the neck, on the right with insertion of a Redon drain, on the left with insertion of 2 flaps. Thorough inspection of the flap, which is vital. Removal of split skin + wound closure of the forearm: At the same time, large areas of split skin are removed from the right thigh in the usual manner. Application of sterile wound dressing in the area of the donor site. Two-layer wound closure in the area of the proximal forearm. Application of a wound dressing and a forearm splint. Completion of graft elevation without complications. Tracheostoma creation: A horizontal incision of about 4 cm 2 QF is made above the jugulum, sharply cutting through the skin, subcutaneous tissue and the platysma. The prelaryngeal musculature or infrahyoid musculature is exposed, entered in the midline and the thyroid gland is exposed. Dissection of the trachea between the cricoid cartilage and isthmus. The isthmus is cut and stitched on both sides. No major bleeding. Between the 2nd and 3rd tracheal cartilage clasp, the trachea is entered and a visor tracheotomy is created. The mucocutaneous anastomosis is created cranially and caudally. The patient is then intubated using an 8-gauge cannula. Completion of the procedure without complications. Then reintubation and insertion of an 8-gauge tracheostomy tube. The procedure is completed without complications. Patient goes to the intensive care unit for monitoring. Please leave heparin perfusor running at 1 ml/h for a further 5 days. Flap control via enoral inspection for 5 days according to schedule. Feeding via the inserted PEG tube for 10-12 days, then X-ray pre-swallow and, if necessary, diet build-up. However, swallowing training should always be planned due to the size and extent of the defect. Aspiration initially likely here. Overall cT3, more likely cT4 oropharyngeal carcinoma right cN2b. After receiving the final histology, please present at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/443/InvasionFront_CD3_block10_x1_y5_patient443_0.json b/443/InvasionFront_CD3_block10_x1_y5_patient443_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cec6d0df89d30db069f4773cc511eec08afb1333 --- /dev/null +++ b/443/InvasionFront_CD3_block10_x1_y5_patient443_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5896.9, + "Centroid Y µm": 17515.7, + "Num Detections": 25168, + "Num Negative": 23909, + "Num Positive": 1259, + "Positive %": 5.002, + "Num Positive per mm^2": 481.15 + } +} \ No newline at end of file diff --git a/443/InvasionFront_CD3_block10_x2_y5_patient443_1.json b/443/InvasionFront_CD3_block10_x2_y5_patient443_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2fd79ed72d82158e16acf9015007a6577884ebdc --- /dev/null +++ b/443/InvasionFront_CD3_block10_x2_y5_patient443_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8720.4, + "Centroid Y µm": 17540.7, + "Num Detections": 23799, + "Num Negative": 21974, + "Num Positive": 1825, + "Positive %": 7.668, + "Num Positive per mm^2": 717.74 + } +} \ No newline at end of file diff --git a/443/InvasionFront_CD8_block10_x1_y5_patient443_0.json b/443/InvasionFront_CD8_block10_x1_y5_patient443_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c5abbfe545f8472a6810ea492f806ea5d735ccf5 --- /dev/null +++ b/443/InvasionFront_CD8_block10_x1_y5_patient443_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5047.3, + "Centroid Y µm": 18440.2, + "Num Detections": 25218, + "Num Negative": 21880, + "Num Positive": 3338, + "Positive %": 13.24, + "Num Positive per mm^2": 1309.0 + } +} \ No newline at end of file diff --git a/443/InvasionFront_CD8_block10_x2_y5_patient443_1.json b/443/InvasionFront_CD8_block10_x2_y5_patient443_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a9714be83cf06867e9c57146d3b3410f99545f67 --- /dev/null +++ b/443/InvasionFront_CD8_block10_x2_y5_patient443_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7920.8, + "Centroid Y µm": 18115.4, + "Num Detections": 23769, + "Num Negative": 20329, + "Num Positive": 3440, + "Positive %": 14.47, + "Num Positive per mm^2": 1366.5 + } +} \ No newline at end of file diff --git a/443/TumorCenter_CD3_block10_x1_y5_patient443_0.json b/443/TumorCenter_CD3_block10_x1_y5_patient443_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e3abad330b07ab3a4ce7510f604a9102b20e6127 --- /dev/null +++ b/443/TumorCenter_CD3_block10_x1_y5_patient443_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 12618.3, + "Num Detections": 18830, + "Num Negative": 16559, + "Num Positive": 2271, + "Positive %": 12.06, + "Num Positive per mm^2": 1028.5 + } +} \ No newline at end of file diff --git a/443/TumorCenter_CD3_block10_x2_y5_patient443_1.json b/443/TumorCenter_CD3_block10_x2_y5_patient443_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2cd3f6d2a1f57f5439bff6accff32d52508e54b8 --- /dev/null +++ b/443/TumorCenter_CD3_block10_x2_y5_patient443_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9070.2, + "Centroid Y µm": 12568.3, + "Num Detections": 23640, + "Num Negative": 18691, + "Num Positive": 4949, + "Positive %": 20.93, + "Num Positive per mm^2": 1952.6 + } +} \ No newline at end of file diff --git a/443/TumorCenter_CD8_block10_x1_y5_patient443_0.json b/443/TumorCenter_CD8_block10_x1_y5_patient443_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7b6cfe06bb71b41fc161f8a13145c1f7ae42f2b3 --- /dev/null +++ b/443/TumorCenter_CD8_block10_x1_y5_patient443_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3748.0, + "Centroid Y µm": 13392.9, + "Num Detections": 21869, + "Num Negative": 20456, + "Num Positive": 1413, + "Positive %": 6.461, + "Num Positive per mm^2": 598.42 + } +} \ No newline at end of file diff --git a/443/TumorCenter_CD8_block10_x2_y5_patient443_1.json b/443/TumorCenter_CD8_block10_x2_y5_patient443_1.json new file mode 100644 index 0000000000000000000000000000000000000000..73bd3e0934cdcd9bf32b759d370ca63a4e0c5e51 --- /dev/null +++ b/443/TumorCenter_CD8_block10_x2_y5_patient443_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 13367.9, + "Num Detections": 23384, + "Num Negative": 19459, + "Num Positive": 3925, + "Positive %": 16.78, + "Num Positive per mm^2": 1539.4 + } +} \ No newline at end of file diff --git a/443/history_text.txt b/443/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d9ed8944e687d7599572204080b67864b7ec0fe --- /dev/null +++ b/443/history_text.txt @@ -0,0 +1 @@ +Suspected cT2 cN2a tonsillar carcinoma on the left in the preoperative CT neck/thorax. Overall indication for the above-mentioned procedure. \ No newline at end of file diff --git a/443/icd_codes.txt b/443/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cd19e299bacb63b8413234b5062666766a5d9b4a --- /dev/null +++ b/443/icd_codes.txt @@ -0,0 +1 @@ +V.a. cT2 cN1 Tonsillen-CA links[C09.0 ] \ No newline at end of file diff --git a/443/ops_codes.txt b/443/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fcc9eb3127b5699ceca5ec2e8063ed3ed174e94c --- /dev/null +++ b/443/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische ÖGD[1-632 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Transorale Tumortonsillektomie[5-281.2 ] \ No newline at end of file diff --git a/443/patient_clinical_data.json b/443/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9939d2bf6cd17a7ebce75a9e1c04c56a5aa6d1b7 --- /dev/null +++ b/443/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 1, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/443/patient_pathological_data.json b/443/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..39c484eb5e5ec91df6aa32e21764f52663df1a54 --- /dev/null +++ b/443/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "443", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 18.0 +} \ No newline at end of file diff --git a/443/surgery_description.txt b/443/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7751c7d394c35fb81d906da1e27ae4a3ef4f0dac --- /dev/null +++ b/443/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy and Panendoscopy diff --git a/443/surgery_report.txt b/443/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c69d61e22ab955922776d92bf86f6dd856a151e1 --- /dev/null +++ b/443/surgery_report.txt @@ -0,0 +1 @@ +After team time-out, induction of anesthesia by the anesthesia colleagues. Then direct tracheoscopy by the surgeon. Abnormal mucosal conditions down to the carina. Then intubation by the surgeon. This is successful without any problems. The surgeon now positions the patient's head. Now perform the gastroscopy. Enter with the flexible esophagoscope and advance into the stomach. Typical gastric mucosal folds without further abnormalities. Even after inversion, the gastroesophageal junction is unremarkable. No abnormalities in the esophagus on reflection. Then, insertion with the Kleinsasser C-tube and inspection of the hypopharynx on both sides. Here the mucosal conditions were unremarkable down to the esophageal entrance as well as in the postcricoid area. Now, if the larynx is difficult to adjust, change to Kleinsasser D-tube. Inconspicuous mucosa in the area of the endolarynx and the epiglottis as well as the interary area. Now insertion of the Mc Ivor oral spatula and demonstration of findings on . A rough mass was found in the area of the left tonsil, which, however, remained limited to the tonsil lobe. The anterior and posterior palatal arch do not appear to be infiltrated, nor does the base of the tongue. In the rest of the oropharynx and in the oral cavity, inconspicuous mucosal conditions. The tumor is now macroscopically excised in toto in the sense of an extended tonsillectomy using a dissection technique with a sufficient safety margin while sparing the posterior palatal arch. The tumor specimen is thread-marked for histology. A resection is then taken in the area of the wound bed and the entire area is covered with margin samples. These are sent separately for final histology. Finally, subtle hemostasis using H2O2-soaked swabs and bipolar coagulation. Finally, dry mucosal conditions and completion of the procedure without complications. Repositioning of the patient by the surgeon. Conclusion: Overall macroscopic in sano resection of a cT2 tonsillar carcinoma on the left. There is a very small defect in the left oropharyngeal side wall. Waiting for the histology and planning a neck dissection of the left side. \ No newline at end of file diff --git a/444/InvasionFront_CD3_block12_x5_y9_patient444_0.json b/444/InvasionFront_CD3_block12_x5_y9_patient444_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dd5c9f9e5093893864d664be75d1b0d1e51d95b7 --- /dev/null +++ b/444/InvasionFront_CD3_block12_x5_y9_patient444_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 27485.4, + "Num Detections": 17344, + "Num Negative": 15299, + "Num Positive": 2045, + "Positive %": 11.79, + "Num Positive per mm^2": 918.99 + } +} \ No newline at end of file diff --git a/444/InvasionFront_CD3_block12_x6_y9_patient444_1.json b/444/InvasionFront_CD3_block12_x6_y9_patient444_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1fd0dc148a5f31677877d2cc510fd988452aafde --- /dev/null +++ b/444/InvasionFront_CD3_block12_x6_y9_patient444_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 27710.3, + "Num Detections": 18292, + "Num Negative": 16625, + "Num Positive": 1667, + "Positive %": 9.113, + "Num Positive per mm^2": 709.86 + } +} \ No newline at end of file diff --git a/444/InvasionFront_CD8_block12_x5_y9_patient444_0.json b/444/InvasionFront_CD8_block12_x5_y9_patient444_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a0d22f8a3b4ce326869db7af0186a9b9025f4325 --- /dev/null +++ b/444/InvasionFront_CD8_block12_x5_y9_patient444_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17565.7, + "Centroid Y µm": 26086.2, + "Num Detections": 17629, + "Num Negative": 15519, + "Num Positive": 2110, + "Positive %": 11.97, + "Num Positive per mm^2": 925.79 + } +} \ No newline at end of file diff --git a/444/InvasionFront_CD8_block12_x6_y9_patient444_1.json b/444/InvasionFront_CD8_block12_x6_y9_patient444_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0d0888e256e0f76d47a78c3ad2165b9b1f9464a9 --- /dev/null +++ b/444/InvasionFront_CD8_block12_x6_y9_patient444_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20139.3, + "Centroid Y µm": 26036.2, + "Num Detections": 18655, + "Num Negative": 17828, + "Num Positive": 827, + "Positive %": 4.433, + "Num Positive per mm^2": 358.1 + } +} \ No newline at end of file diff --git a/444/TumorCenter_CD3_block12_x5_y9_patient444_0.json b/444/TumorCenter_CD3_block12_x5_y9_patient444_0.json new file mode 100644 index 0000000000000000000000000000000000000000..11c786b647b8a79b71df6826231105ee0618dc62 --- /dev/null +++ b/444/TumorCenter_CD3_block12_x5_y9_patient444_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15541.8, + "Centroid Y µm": 22563.1, + "Num Detections": 17111, + "Num Negative": 15618, + "Num Positive": 1493, + "Positive %": 8.725, + "Num Positive per mm^2": 674.06 + } +} \ No newline at end of file diff --git a/444/TumorCenter_CD3_block12_x6_y9_patient444_1.json b/444/TumorCenter_CD3_block12_x6_y9_patient444_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1c66e74ce0fe51072c7d19caa91b9b94a0297f82 --- /dev/null +++ b/444/TumorCenter_CD3_block12_x6_y9_patient444_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18015.5, + "Centroid Y µm": 22638.0, + "Num Detections": 18233, + "Num Negative": 15317, + "Num Positive": 2916, + "Positive %": 15.99, + "Num Positive per mm^2": 1320.9 + } +} \ No newline at end of file diff --git a/444/TumorCenter_CD8_block12_x5_y9_patient444_0.json b/444/TumorCenter_CD8_block12_x5_y9_patient444_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3352fd1973f663dc835019b2d2b9f00963a302eb --- /dev/null +++ b/444/TumorCenter_CD8_block12_x5_y9_patient444_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 32058.0, + "Num Detections": 12770, + "Num Negative": 12118, + "Num Positive": 652, + "Positive %": 5.106, + "Num Positive per mm^2": 302.84 + } +} \ No newline at end of file diff --git a/444/TumorCenter_CD8_block12_x6_y9_patient444_1.json b/444/TumorCenter_CD8_block12_x6_y9_patient444_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a6e8914bff6a8b564a979537a561e2554d446f71 --- /dev/null +++ b/444/TumorCenter_CD8_block12_x6_y9_patient444_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21088.8, + "Centroid Y µm": 32232.9, + "Num Detections": 15701, + "Num Negative": 13763, + "Num Positive": 1938, + "Positive %": 12.34, + "Num Positive per mm^2": 894.26 + } +} \ No newline at end of file diff --git a/444/history_text.txt b/444/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/444/icd_codes.txt b/444/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/444/ops_codes.txt b/444/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/444/patient_clinical_data.json b/444/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..099eddf4fbde531e770e56a295cd36abd487e011 --- /dev/null +++ b/444/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/444/patient_pathological_data.json b/444/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f965743c3094f409a46e8ae71565859f84db4168 --- /dev/null +++ b/444/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "444", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/444/surgery_description.txt b/444/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..29a213369910c6190eb1287546ea128ec0c28e9e --- /dev/null +++ b/444/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Tumor resection, Left neck dissection, Possibly PEG (according to the surgical protocol) diff --git a/444/surgery_report.txt b/444/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/445/InvasionFront_CD3_block16_x5_y12_patient445_0.json b/445/InvasionFront_CD3_block16_x5_y12_patient445_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad319d98c5aeb74604fb47d9fcb14fc532ace293 --- /dev/null +++ b/445/InvasionFront_CD3_block16_x5_y12_patient445_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 34281.8, + "Num Detections": 20767, + "Num Negative": 18375, + "Num Positive": 2392, + "Positive %": 11.52, + "Num Positive per mm^2": 1004.6 + } +} \ No newline at end of file diff --git a/445/InvasionFront_CD3_block16_x6_y12_patient445_1.json b/445/InvasionFront_CD3_block16_x6_y12_patient445_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d219dd40b2a423f2993eb818ee88dacdced16cd6 --- /dev/null +++ b/445/InvasionFront_CD3_block16_x6_y12_patient445_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 34281.8, + "Num Detections": 18852, + "Num Negative": 18029, + "Num Positive": 823, + "Positive %": 4.366, + "Num Positive per mm^2": 346.82 + } +} \ No newline at end of file diff --git a/445/InvasionFront_CD8_block16_x5_y12_patient445_0.json b/445/InvasionFront_CD8_block16_x5_y12_patient445_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8233d1cc745ac94236784dc7c4e463f0000f1123 --- /dev/null +++ b/445/InvasionFront_CD8_block16_x5_y12_patient445_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15541.6, + "Centroid Y µm": 28956.2, + "Num Detections": 19728, + "Num Negative": 16905, + "Num Positive": 2823, + "Positive %": 14.31, + "Num Positive per mm^2": 1190.0 + } +} \ No newline at end of file diff --git a/445/InvasionFront_CD8_block16_x6_y12_patient445_1.json b/445/InvasionFront_CD8_block16_x6_y12_patient445_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0166ade01593277660a2e6f06958c28f41dfcad4 --- /dev/null +++ b/445/InvasionFront_CD8_block16_x6_y12_patient445_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17939.2, + "Centroid Y µm": 29123.8, + "Num Detections": 16845, + "Num Negative": 15608, + "Num Positive": 1237, + "Positive %": 7.343, + "Num Positive per mm^2": 563.21 + } +} \ No newline at end of file diff --git a/445/TumorCenter_CD8_block16_x5_y12_patient445_0.json b/445/TumorCenter_CD8_block16_x5_y12_patient445_0.json new file mode 100644 index 0000000000000000000000000000000000000000..80375ef8c9a7584fd76716b7c6a8bb6fedfc0865 --- /dev/null +++ b/445/TumorCenter_CD8_block16_x5_y12_patient445_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 30483.9, + "Num Detections": 21292, + "Num Negative": 17445, + "Num Positive": 3847, + "Positive %": 18.07, + "Num Positive per mm^2": 1571.3 + } +} \ No newline at end of file diff --git a/445/TumorCenter_CD8_block16_x6_y12_patient445_1.json b/445/TumorCenter_CD8_block16_x6_y12_patient445_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fb15cab5889884dd8addcd1d989196fbbdfd121b --- /dev/null +++ b/445/TumorCenter_CD8_block16_x6_y12_patient445_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 30458.9, + "Num Detections": 21051, + "Num Negative": 18571, + "Num Positive": 2480, + "Positive %": 11.78, + "Num Positive per mm^2": 998.17 + } +} \ No newline at end of file diff --git a/445/history_text.txt b/445/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6014c490a34b229f2d8fb87f5dd6688460ddcab2 --- /dev/null +++ b/445/history_text.txt @@ -0,0 +1 @@ +Patient with multiple endoscopies and sampling as well as decortication twice on the right side for dysplasia in the laryngeal region. Now presentation with suspected carcinoma. At the last MLE, a squamous cell carcinoma of the right vocal fold was confirmed. This was described as being located in the anterior part of the right vocal cord up to the anterior commissure. \ No newline at end of file diff --git a/445/icd_codes.txt b/445/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/445/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/445/ops_codes.txt b/445/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7dbad1feb2ab91b1c8d33663f2e9ac067ecd10e1 --- /dev/null +++ b/445/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Hemilaryngektomie[5-301.x ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/445/patient_clinical_data.json b/445/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e7fac3c930ca571265e3d239909a967a2c4f6b9c --- /dev/null +++ b/445/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "pembrolizumab", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/445/patient_pathological_data.json b/445/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..55aa7eadf269b650f3bd8883120d1cd8cebce349 --- /dev/null +++ b/445/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "445", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/445/surgery_description.txt b/445/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..650ca53e6ad4299b68dfff24184ca045017de5ed --- /dev/null +++ b/445/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection according to Leroux-Robert, Tracheostomy, MLE (Microlaryngoscopy and Endoscopy) diff --git a/445/surgery_report.txt b/445/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..639ad28116e587dc01a36afce7e1b11b228ba112 --- /dev/null +++ b/445/surgery_report.txt @@ -0,0 +1 @@ +After intubation of the patient, MLE is now performed: the thickened vocal fold is visible, especially on the right, up to the anterior commissure. Overall, the tumor also appears to be growing into the ventriculus laryngeus. Overview difficult due to the poor adjustability, therefore, due to the overall situation, the decision was made to perform the operation by means of partial laryngeal resection from the outside. Therefore now repositioning. Injection of a total of 8 ml Ultracaine 1% with adrenaline. Sterile draping. Zigzag skin incision. Exposure of the larynx. Creation of a perichondrium flap from the left side. Then opening of the larynx, whereby a triangle is cut out more on the right than on the left with the wheel. The larynx is then opened. Entering the larynx from the supraglottic side. Now inspect the tumor. Cut around the tumor or the visible thickenings and palpable thickenings with a safety margin of at least 4 mm on all sides. The entire vocal fold up to the arytenoid area on the right, the mucosa up to the upper edge of the cricoid cartilage, the entire area of the pouch ligament. The tumor, including the perichondrium, is removed from the right side after it has been dissected away from the cartilage, as well as from the front left side, whereby the anterior vocal fold is also resected macroscopically in the anterior part of the healthy area. Resection caudally up to the ligamentum conicum. Tumor is marked with sutures. Samples are taken from the supraglottic margin and the basal anterior margin. In the frozen section at the border of the supraglottic to the arytenoid region or the arytenoid region to the subglottic region, the tumor forms a margin. Also in the area of the vocal fold on the front left. A resection is performed on the left side, which includes the supraglottic, glottic and subglottic areas and is sent in marked with sutures. The sutures are all remote from the tumor. Also post-resection dorsal right and subglottic right. A marginal sample is then taken from subglottic and dorsal in the arytenoid region. Here in the first post-resection supraglottic left still clear carcinoma infiltrates, glottic and subglottic none. In the direction of the arytenoid region, there is a tumor, although metaplasia is also possible. Post-resection is therefore also recommended here. Overall, the resection in the arytenoid region on the right has already progressed to the interary area. Further massive removal of the mucosa is not possible without functional damage. Therefore, mucosa is removed from the arytenoid region in the dorsal area and subglottically only as a resection. In addition, an extensive resection is performed in the glottic and supraglottic area on the left, whereby the sutures are placed remote from the tumor. Ultimately, a vocal fold remnant remains on the left, supraglottic mucosal remnant on the left. Overall, the situation is now borderline. In principle, there is also a suspicion of field carcinomatization with an overall macroscopically invisible tumour extension. Now laryngeal closure. Creation of drill holes and 2 Vicryl sutures, which adapt the cartilage. Perichondrium is sutured over the laryngeal cartilage defect or over the laryngeal cartilage. The muscle layer is sutured over this. A further layer of soft tissue is then applied. The skin is then closed in layers with the insertion of a flap. A tracheostoma was also created via a slightly deeper, small Kocher collar incision. The trachea was first exposed by dissecting through the subcutaneous tissue. The thyroid isthmus was cut and ligated beforehand. A modified Björk flap is then created, which has a wide stalk. The tracheostoma is then epithelialized in the typical manner. An 8 mm tracheostomy tube is then inserted. Overall, the procedure is completed without complications. Patient goes to the intensive care unit for monitoring. Overall borderline situation as far as partial laryngeal resection is concerned. No further resection can be performed, particularly in the direction of the interary space, without the interary region shrinking and leading to respiratory distress. If tumor residues are still present, a laryngectomy should be discussed in any case. Even in an R0 situation, the situation is borderline, so that a laryngectomy would ultimately be the safest option for long-term survival. Postoperative nutrition via a nasogastric tube if necessary. \ No newline at end of file diff --git a/446/InvasionFront_CD3_block22_x5_y3_patient446_0.json b/446/InvasionFront_CD3_block22_x5_y3_patient446_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f47d7e1f6da80f90d4ef9e48bfe90727de35c07f --- /dev/null +++ b/446/InvasionFront_CD3_block22_x5_y3_patient446_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 19264.8, + "Num Detections": 19436, + "Num Negative": 18677, + "Num Positive": 759, + "Positive %": 3.905, + "Num Positive per mm^2": 315.26 + } +} \ No newline at end of file diff --git a/446/InvasionFront_CD3_block22_x6_y3_patient446_1.json b/446/InvasionFront_CD3_block22_x6_y3_patient446_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dffa704d2e431040ccdf5fa196a6c53684dc2eb1 --- /dev/null +++ b/446/InvasionFront_CD3_block22_x6_y3_patient446_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19664.6, + "Centroid Y µm": 19489.7, + "Num Detections": 19696, + "Num Negative": 18135, + "Num Positive": 1561, + "Positive %": 7.925, + "Num Positive per mm^2": 699.11 + } +} \ No newline at end of file diff --git a/446/InvasionFront_CD8_block22_x5_y3_patient446_0.json b/446/InvasionFront_CD8_block22_x5_y3_patient446_0.json new file mode 100644 index 0000000000000000000000000000000000000000..02c7596f7e2d78d92f70a8509e117bd30d6620ee --- /dev/null +++ b/446/InvasionFront_CD8_block22_x5_y3_patient446_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 7745.9, + "Num Detections": 16916, + "Num Negative": 16455, + "Num Positive": 461, + "Positive %": 2.725, + "Num Positive per mm^2": 202.4 + } +} \ No newline at end of file diff --git a/446/InvasionFront_CD8_block22_x6_y3_patient446_1.json b/446/InvasionFront_CD8_block22_x6_y3_patient446_1.json new file mode 100644 index 0000000000000000000000000000000000000000..82b2818bf69a701c2eafb7070ffbe60f4bd6ad5c --- /dev/null +++ b/446/InvasionFront_CD8_block22_x6_y3_patient446_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21463.6, + "Centroid Y µm": 7446.1, + "Num Detections": 14581, + "Num Negative": 13774, + "Num Positive": 807, + "Positive %": 5.535, + "Num Positive per mm^2": 418.17 + } +} \ No newline at end of file diff --git a/446/TumorCenter_CD3_block22_x5_y3_patient446_0.json b/446/TumorCenter_CD3_block22_x5_y3_patient446_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5a15902960be9142febc62b238faf7e8639d4172 --- /dev/null +++ b/446/TumorCenter_CD3_block22_x5_y3_patient446_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16991.0, + "Centroid Y µm": 8470.5, + "Num Detections": 18319, + "Num Negative": 17807, + "Num Positive": 512, + "Positive %": 2.795, + "Num Positive per mm^2": 248.83 + } +} \ No newline at end of file diff --git a/446/TumorCenter_CD3_block22_x6_y3_patient446_1.json b/446/TumorCenter_CD3_block22_x6_y3_patient446_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a3f1acf81d9fc265b7d5611b0db141c6c5d3ffd9 --- /dev/null +++ b/446/TumorCenter_CD3_block22_x6_y3_patient446_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 8770.4, + "Num Detections": 13735, + "Num Negative": 12499, + "Num Positive": 1236, + "Positive %": 8.999, + "Num Positive per mm^2": 694.54 + } +} \ No newline at end of file diff --git a/446/TumorCenter_CD8_block22_x5_y3_patient446_0.json b/446/TumorCenter_CD8_block22_x5_y3_patient446_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d5032f1a7f66a95355b4d8e792aa9706103e97eb --- /dev/null +++ b/446/TumorCenter_CD8_block22_x5_y3_patient446_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19289.8, + "Centroid Y µm": 17440.8, + "Num Detections": 17508, + "Num Negative": 16598, + "Num Positive": 910, + "Positive %": 5.198, + "Num Positive per mm^2": 440.02 + } +} \ No newline at end of file diff --git a/446/TumorCenter_CD8_block22_x6_y3_patient446_1.json b/446/TumorCenter_CD8_block22_x6_y3_patient446_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b4a52f8c31116b6f0164979df617e0274822fc06 --- /dev/null +++ b/446/TumorCenter_CD8_block22_x6_y3_patient446_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21513.6, + "Centroid Y µm": 17715.6, + "Num Detections": 14690, + "Num Negative": 12498, + "Num Positive": 2192, + "Positive %": 14.92, + "Num Positive per mm^2": 1188.0 + } +} \ No newline at end of file diff --git a/446/history_text.txt b/446/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6bf9ba56a9b76b79855dba7f40aa900484fdb15c --- /dev/null +++ b/446/history_text.txt @@ -0,0 +1 @@ +The patient presented for a second opinion from the hospital , where a panendoscopy was performed and a tumor was found in the area of the medial wall of the piriform sinus on the left side. The patient still needed time to think about the planned laryngectomy and partial pharyngectomy and a second opinion. Therefore, the above-mentioned procedure was performed, as the patient was ultimately able to decide on the operation, but wanted the operation in . \ No newline at end of file diff --git a/446/icd_codes.txt b/446/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9025024bf695ed4c849835b876a53b83aaea81fd --- /dev/null +++ b/446/icd_codes.txt @@ -0,0 +1 @@ +Kehlkopfknorpelkarzinom[C32.3 L] Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] \ No newline at end of file diff --git a/446/ops_codes.txt b/446/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bc328da1b76dd037ec10817c25fbc0c33fa60bf2 --- /dev/null +++ b/446/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Diagnostische Stützlaryngoskopie nach Kleinsasser[1-610.2 ] Direkte Hypopharyngoskopie[1-611.0 ] Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.x1 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Wechsel perkutan-endoskopische Gastrostomie [PEG][8-123.0 ] \ No newline at end of file diff --git a/446/patient_clinical_data.json b/446/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..20367e57ee1090b7d672c796a4e3eb7b42d8804d --- /dev/null +++ b/446/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 62, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/446/patient_pathological_data.json b/446/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..59e9ca2d82ec876e4c7d3d644e7cac2712783101 --- /dev/null +++ b/446/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "446", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/446/surgery_description.txt b/446/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5c097d5190b6fe0641af1a406c4d5b1baddff77d --- /dev/null +++ b/446/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Partial pharyngectomy, and Neck dissection diff --git a/446/surgery_report.txt b/446/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b9ec3dd6b54e1be4e559b80ffd8322b98fa053f6 --- /dev/null +++ b/446/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia and intubation by the anesthesia colleagues. Intubation was very difficult and only possible orally with great difficulty, then sterile washing and draping, prior inspection with the small water tube and visualization of the tumor, the tumor is located on the medial wall of the piriform sinus and extends to the aryepiglottic fold and the arytenoid cartilage on the left side. The tumor is exophytic and affects the entire left medial and anterior wall of the piriform sinus; the tip of the piriform sinus and the esophageal entrance are tumor-free. A PEG is now inserted using the suture pull-through method with good diaphanoscopy. Then sterile washing and draping and creation of an apron flap in the usual manner. Then release of the larynx and detachment of the neck vessel sheath on both sides. Release of the piriform sinus on the right side, this is successful without any problems. Then only very slight and partial release of the piriform sinus on the left side, then release of the hyoid bone and performance of the tracheotomy in the usual manner directly below the cricoid cartilage. Then perform the pharyngoscopy. To do this, enter with the Hartmann spatula directly above the epiglottis. Then disluxation of the epiglottis and detachment of the mucosa of the lingual surface of the epiglottis and detachment of the larynx, initially on the right side. Then inspection of the tumor and removal of the tumor in the pharyngeal part in the piriform sinus on the left with a safety margin of 1.5 cm and removal of the larynx below the cricoid cartilage. Removal of marginal samples from the mucosa. All marginal samples are tumor-free, free of carcinoma in situ and without high-grade dysplasia. Now inspection of the mucosa, intraoperative demonstration on and . A joint decision is made to dispense with a transplant as there is still sufficient local mucosa. Now complete the neck dissection on both sides, on the right side through and . For this, expose the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Then free preparation of the internal jugular vein and the facial vein, then removal of the neck preparation IIa to Va while sparing the plexus branches. Several small roundish metastases were found in level II, the levels were sent in individually as part of the lymph node study and the neck dissection was carried out on the left side at the same time. This revealed a very large lymph node conglomerate that completely infiltrated the internal jugular vein, which was therefore removed. The vagus nerve was also found to be infiltrated. In consultation with , this is also resected; the metastasis can then be detached from the common carotid artery and the external and internal carotid arteries. The accessorius nerve can be preserved, but the more distal plexus branches are interspersed with metastases and infiltrated, so most of these must be resected, resulting in a radical neck dissection on the left side and a modified radical neck dissection on the right side. A Provox-Vega prosthesis is then placed in the usual manner, followed by a three-layer pharyngeal suture in the usual manner. Incision of the tracheostoma in the usual manner and two-layer wound closure after insertion of 2 Redon drains. \ No newline at end of file diff --git a/447/InvasionFront_CD3_block4_x3_y7_patient447_0.json b/447/InvasionFront_CD3_block4_x3_y7_patient447_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6ae423937ddc6e7b4e503b7c777bbe5c5a63fb2e --- /dev/null +++ b/447/InvasionFront_CD3_block4_x3_y7_patient447_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 23762.4, + "Num Detections": 23964, + "Num Negative": 21469, + "Num Positive": 2495, + "Positive %": 10.41, + "Num Positive per mm^2": 1138.5 + } +} \ No newline at end of file diff --git a/447/InvasionFront_CD3_block4_x4_y7_patient447_1.json b/447/InvasionFront_CD3_block4_x4_y7_patient447_1.json new file mode 100644 index 0000000000000000000000000000000000000000..58d3a767d1320f70c89dd6ec3d0593b53311feec --- /dev/null +++ b/447/InvasionFront_CD3_block4_x4_y7_patient447_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 23637.5, + "Num Detections": 23722, + "Num Negative": 22119, + "Num Positive": 1603, + "Positive %": 6.757, + "Num Positive per mm^2": 658.47 + } +} \ No newline at end of file diff --git a/447/InvasionFront_CD8_block4_x3_y7_patient447_0.json b/447/InvasionFront_CD8_block4_x3_y7_patient447_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d6b0aeab0017d4e68b2f4f37045e47e9fee649f6 --- /dev/null +++ b/447/InvasionFront_CD8_block4_x3_y7_patient447_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11243.5, + "Centroid Y µm": 22349.9, + "Num Detections": 24963, + "Num Negative": 22644, + "Num Positive": 2319, + "Positive %": 9.29, + "Num Positive per mm^2": 1006.8 + } +} \ No newline at end of file diff --git a/447/InvasionFront_CD8_block4_x4_y7_patient447_1.json b/447/InvasionFront_CD8_block4_x4_y7_patient447_1.json new file mode 100644 index 0000000000000000000000000000000000000000..155eb490e310ff6886066d6c9d892b727ae9a51e --- /dev/null +++ b/447/InvasionFront_CD8_block4_x4_y7_patient447_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 22338.2, + "Num Detections": 23245, + "Num Negative": 22534, + "Num Positive": 711, + "Positive %": 3.059, + "Num Positive per mm^2": 284.61 + } +} \ No newline at end of file diff --git a/447/TumorCenter_CD3_block4_x3_y7_patient447_0.json b/447/TumorCenter_CD3_block4_x3_y7_patient447_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5664c3b83170de67cd0faa207c2d1f97a66055f4 --- /dev/null +++ b/447/TumorCenter_CD3_block4_x3_y7_patient447_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 18065.4, + "Num Detections": 23583, + "Num Negative": 21218, + "Num Positive": 2365, + "Positive %": 10.03, + "Num Positive per mm^2": 999.09 + } +} \ No newline at end of file diff --git a/447/TumorCenter_CD3_block4_x4_y7_patient447_1.json b/447/TumorCenter_CD3_block4_x4_y7_patient447_1.json new file mode 100644 index 0000000000000000000000000000000000000000..236786a56334b2bc5f1d259b9c404b74178eef53 --- /dev/null +++ b/447/TumorCenter_CD3_block4_x4_y7_patient447_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 18115.4, + "Num Detections": 20201, + "Num Negative": 18628, + "Num Positive": 1573, + "Positive %": 7.787, + "Num Positive per mm^2": 781.25 + } +} \ No newline at end of file diff --git a/447/TumorCenter_CD8_block4_x3_y7_patient447_0.json b/447/TumorCenter_CD8_block4_x3_y7_patient447_0.json new file mode 100644 index 0000000000000000000000000000000000000000..297c4282f6dffbe5d698a00043e295db6246dc23 --- /dev/null +++ b/447/TumorCenter_CD8_block4_x3_y7_patient447_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11493.9, + "Centroid Y µm": 17865.5, + "Num Detections": 23203, + "Num Negative": 21339, + "Num Positive": 1864, + "Positive %": 8.033, + "Num Positive per mm^2": 811.41 + } +} \ No newline at end of file diff --git a/447/TumorCenter_CD8_block4_x4_y7_patient447_1.json b/447/TumorCenter_CD8_block4_x4_y7_patient447_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d52871e26121db2a2a57057af277b6c115a58dbc --- /dev/null +++ b/447/TumorCenter_CD8_block4_x4_y7_patient447_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 18115.4, + "Num Detections": 18918, + "Num Negative": 17709, + "Num Positive": 1209, + "Positive %": 6.391, + "Num Positive per mm^2": 671.34 + } +} \ No newline at end of file diff --git a/447/history_text.txt b/447/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0478057de93a8dd5d2f7d6e17f4211dd7b698f59 --- /dev/null +++ b/447/history_text.txt @@ -0,0 +1 @@ +The patient has a post-op panendoscopy with a sample biopsy of a cT1 cN1 tongue base carcinoma on the right p16 positive <2016>. B-image sonography shows at least one cT1 to cN2c neck status, no relevant noxious substances, maximum 0.2 beer/day. \ No newline at end of file diff --git a/447/icd_codes.txt b/447/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c935d7eae58466b4e7ef3d21ca06a99151e82d83 --- /dev/null +++ b/447/icd_codes.txt @@ -0,0 +1 @@ +Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/447/ops_codes.txt b/447/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..26d85b5e0037928ab91446d5057e7a7e54a373e0 --- /dev/null +++ b/447/ops_codes.txt @@ -0,0 +1 @@ +Laserkoagulation Zungengewebe[5-250.31 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/447/patient_clinical_data.json b/447/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f3597e92bcead9a5ff8908464aff643ecc70f29 --- /dev/null +++ b/447/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 69, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/447/patient_pathological_data.json b/447/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..411f1219a5db441e0118fe6a3a25336287e28ac2 --- /dev/null +++ b/447/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "447", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Sarcomatoid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/447/surgery_description.txt b/447/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..76516399d4f5bb37873aa8ed579838cfdd162b10 --- /dev/null +++ b/447/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/447/surgery_report.txt b/447/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..10be8694cca2407dd71d987c2a37f6e2c90859c5 --- /dev/null +++ b/447/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating room, active patient identification, consultations with anesthesia colleagues. Therefore, carrying out the team time out. Induction of anesthesia and intubation by the anesthesia colleagues. Then insertion of the PEG gastric tube. Careful insertion of the flexible endoscope under air insufflation. Then positive diaphanoscopy loco typico. Subsequent skin disinfection of the abdomen and upper abdomen, infiltration anesthesia and placement of the PEG gastric tube using the thread pull-through technique without any problems by and . Preoperative administration of 3 g Unacid. The tumor is then resected by . Adjustment of the base of the tongue by with the spreading laryngoscope and the support. Use the microscope. The tumor of at least 1 cm in size described in the panendoscopy is seen in the cranial base of the tongue, not approaching the midline, but there is still questionable unstable mucosa at the caudal medial edge. Now set the laser to cw 8 watts. Mark the resection margins with the laser. Successive resection of the tumor using the laser with the aid of Blakesley. Attention is paid to the lateral vascular bundle. Laser resection is performed up to the borders of the oropharynx laterally and into the vallecula. The mass is then sent to the frozen section in toto with the markings cranial tongue base and lateral oropharyngeal side wall, caudal vallecula and medial. Repeated meticulous hemostasis, then dry wound conditions. The frozen section then shows a CIS forming a margin from 3 o'clock to 12 o'clock. Therefore, the resection is now performed by . To do this, adjust the base of the tongue with the spreading laryngoscope and, with the aid of the support, adjust using a microscope and laser. The laser is set to 8 watts. Now successive resection. Final marginal samples are taken from 3 o'clock/ oropharyngeal side wall to 6 o'clock. A second margin sample from 6 o'clock to 9 o'clock, suture marking at 6 o'clock and third margin sample from 9 o'clock to 12 o'clock. The post-resection shows that the mucosa is completely normal; it is not possible to differentiate between CIS and normal mucosa. Then repeated hemostasis using monopolar coagulation, followed by re-inspection of the surgical site with the Kleinsasser tube. Occasionally targeted bipolar coagulation. There is now a large wound surface over the entire base of the tongue from the right to the opposite side and filling the entire vallecula. Here, however, the wound is dry. Subsequent transition to neck dissection on the right side. Infiltration anesthesia with a total of 20 ml Ultracaine in the area of the neck dissection incision on the right side and on the left side. Skin disinfection of the surgical area and sterile draping of the surgical area. Then mark the landmarks on both sides of the mastoid, jugulum, mandibular angle and mandibular margin and sternocleidomastoid anterior margin. Then mark the skin incisions on the right and left of the mastoid in an arched medial direction and towards the sternocleidomastoid in a caudal direction. Ensure that the incision is as symmetrical as possible on both sides. Now start on the right side. Cut through the cutaneous and subcutaneous tissue, cut through the platysma. Now develop the medial neck preparation and dissect subplatysmal using a scalpel. Expose the anterior margin of the sternocleidomastoid and dissect it caudally. Exposure of the accessorius nerve and sparing of the same. Exposure of the entire course of the jugular vein and protection of the same. This is conspicuously thin, with a jump in caliber only in the caudal part of level IV. Exposure of the cervical vein, which is also exposed and spared. Exposure of the omohyoid muscle and the digaster venter anteriorly and posteriorly and protection of the same. Exposure of the mandibular salivary gland. Exposure of the hypoglossal nerve and sparing of the same. Now resection of the medial neck preparation. Here 2 suspicious level II lymph nodes are noticed. These are resected in toto. Expose the internal and external bifurcation and the superior thyroid artery and spare them. Note: The auricularis magnus nerve was exposed and spared during the skin incision. A larger caliber branch of the external jugular vein was ligated. Now resection of the lateral triangle of the neck. Here, the vagus nerve is first exposed and spared, the accessorius triangle is resected cranial to the accessorius nerve, mobilization under the accessorius nerve. Dissection down to the plexus branches and resection of the lateral neck preparation from cranial to caudal up to level IV as well as level Va and b. The plexus branches are also spared. Removal of the lateral neck preparation. The facial vein could not be visualized. Now targeted bipolar coagulation, irrigation with H202 and Ringer. Increase in pressure to 160, targeted bipolar coagulation, otherwise very dry wound conditions. Application of a 10 redon and two-layer wound closure using subcutaneous and cutaneous sutures. Application of a pressure dressing. Turning to the opposite side. Identical procedure here. First cut through the cutaneous and subcutaneous tissue and the platysma with a scalpel. Expose the auricularis magnus nerve. Sparing of the same. Dissection of the branches of the external jugular vein and ligation of the same. The neck preparation is dissected subplatysmally. Expose the anterior sternocleidomastoid margin and dissect caudally. Exposure of the jugular vein and sparing of the same. Exposure of the accessorius nerve and sparing of the same. Exposure of the omohyoid muscle. Cranial dissection. Exposure of the digaster venter anteriorly and posteriorly as well as the mandibular salivary gland. Now resection of the medial neck preparation, exposing the cervical anus and the hypoglossal nerve, which is spared. Removal of the medial neck specimen. Resection of the lateral neck specimen. The carotid artery and the vagus are still exposed and spared. Level IIa, Va and III are also resected up to level IV. The plexus branches are exposed and spared. Then targeted bipolar coagulation, irrigation with H202 and Ringer. Increase the peep and pressure, then no further bleeding. Dry wound conditions. Insertion of a 10-gauge Redon and two-layer wound closure using subcutaneous and cutaneous sutures. Application of a pressure dressing. Now create a protective tracheostomy. To do this, mark the thyroid incisura, cricoid cartilage, jugulum and the planned skin incision 1 QF below the cricoid cartilage. Now make the skin incision of approx. 3 cm horizontally and cut through the skin and subcutaneous tissue. Expose a larger caliber vein, which is ligated. Dissection of the infrahyal musculature. Incision in the median line. Exposure of the cricoid cartilage, exposure of the isthmus, this is relatively far cranial. Undermining of the isthmus using a clamp. Overall, the isthmus is very narrow, therefore coagulation in the median line and transection of the isthmus. Exposure of the anterior surface of the trachea and the tracheal clips. The brachiocephalic trunk can be palpated in depth. Now identify the area between the 2nd and 3rd cricoid cartilage. Enter with the scissors. Suture with 2 caudal and 2 cranial sutures. Skin suture with 2 stitches on the right and left. Then problem-free reintubation to an 8-gauge cannula and completion of the procedure without complications. Preoperative administration of 3 g Unacid. The patient goes to the intensive care unit intubated and ventilated. Please note the histology. \ No newline at end of file diff --git a/448/InvasionFront_CD3_block12_x5_y6_patient448_0.json b/448/InvasionFront_CD3_block12_x5_y6_patient448_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9a231198adcce2e9d5bfa44587d0e88db54d23b9 --- /dev/null +++ b/448/InvasionFront_CD3_block12_x5_y6_patient448_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 20239.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/448/InvasionFront_CD3_block12_x6_y6_patient448_1.json b/448/InvasionFront_CD3_block12_x6_y6_patient448_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1847e72934adc205779a956acca4461308328ff0 --- /dev/null +++ b/448/InvasionFront_CD3_block12_x6_y6_patient448_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 20439.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/448/InvasionFront_CD8_block12_x5_y6_patient448_0.json b/448/InvasionFront_CD8_block12_x5_y6_patient448_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0ff954baee3ffe0a34e33de208134a828ea6f39 --- /dev/null +++ b/448/InvasionFront_CD8_block12_x5_y6_patient448_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17315.8, + "Centroid Y µm": 18665.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/448/InvasionFront_CD8_block12_x6_y6_patient448_1.json b/448/InvasionFront_CD8_block12_x6_y6_patient448_1.json new file mode 100644 index 0000000000000000000000000000000000000000..335dfc334ddfcd4bc303005a0f1ed4b2986ac8ae --- /dev/null +++ b/448/InvasionFront_CD8_block12_x6_y6_patient448_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19839.5, + "Centroid Y µm": 18565.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/448/TumorCenter_CD3_block12_x5_y6_patient448_0.json b/448/TumorCenter_CD3_block12_x5_y6_patient448_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e4de1735f2d33310954d5841cc4f4201a85de3ed --- /dev/null +++ b/448/TumorCenter_CD3_block12_x5_y6_patient448_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 15142.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/448/TumorCenter_CD3_block12_x6_y6_patient448_1.json b/448/TumorCenter_CD3_block12_x6_y6_patient448_1.json new file mode 100644 index 0000000000000000000000000000000000000000..176c1f37af91ba34025c5b0440fefbc999e08e71 --- /dev/null +++ b/448/TumorCenter_CD3_block12_x6_y6_patient448_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 15167.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/448/TumorCenter_CD8_block12_x5_y6_patient448_0.json b/448/TumorCenter_CD8_block12_x5_y6_patient448_0.json new file mode 100644 index 0000000000000000000000000000000000000000..58e29d2bf4719276f4c231cd3bad2490c424bc7c --- /dev/null +++ b/448/TumorCenter_CD8_block12_x5_y6_patient448_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 24587.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/448/TumorCenter_CD8_block12_x6_y6_patient448_1.json b/448/TumorCenter_CD8_block12_x6_y6_patient448_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a9e0e51973cdb1ba1c476c6911d07fa14aa5b208 --- /dev/null +++ b/448/TumorCenter_CD8_block12_x6_y6_patient448_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21438.6, + "Centroid Y µm": 24711.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/448/history_text.txt b/448/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/448/icd_codes.txt b/448/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce196d0caa0ae248d8ca1cf26ea4b94de6b51cd3 --- /dev/null +++ b/448/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Fossa tonsillaris[C09.0 ] \ No newline at end of file diff --git a/448/ops_codes.txt b/448/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad211a1519624ceaa6cf88d6ebae59c6abcbd183 --- /dev/null +++ b/448/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie (ohne Adenotomie): Radikal, transoral[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] \ No newline at end of file diff --git a/448/patient_clinical_data.json b/448/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..58dd23d0a1d2e26e043b22f11cfd26fe8306a198 --- /dev/null +++ b/448/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 49, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/448/patient_pathological_data.json b/448/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9774b17a4e16e0e3765b00f21333bf74d8b56501 --- /dev/null +++ b/448/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "448", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN2a", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/448/surgery_description.txt b/448/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b5520ff72d7ed846f20d5da08ce1f4d560cd065f --- /dev/null +++ b/448/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy (without adenotonsillectomy): Radical, transoral diff --git a/448/surgery_report.txt b/448/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..874b5bf7f4c8f6d3a3e002fba721eebc8441383d --- /dev/null +++ b/448/surgery_report.txt @@ -0,0 +1 @@ +After intubation by the anesthesia colleagues, entry with the flexible esophagoscope under continuous air insufflation and approach into the stomach. Irritation-free mucosal relief. Subsequent PEG insertion in the usual manner. Now enter with the tonsil retractor and expose the left, histologically confirmed, tumorous tonsil. Mark the resection margins with the electric needle and then generously resect the left tonsil, leaving the posterior palatal arch intact. Part of the base of the tongue is resected caudally. Intermediate bipolar hemostasis. The specimen is then marked with sutures and sent for histological frozen section examination. In the course of the operation, the specimen is found to be tumor-free on all sides. Insertion of a hydrogen swab, bipolar hemostasis and repositioning for neck dissection on the right: Here, first instillation of 10 ml xylocaine with added adrenaline in the area of the front edge of the sternocleidomastoid. Then make a curved incision along the anterior edge of the sternocleidomastoid. Now expose the omohyoid muscle, the accessorius nerve and the digaster muscle. Then expose the entire length of the internal jugular vein. Dissect the neck preparation caudally after exposing the carotid artery and the vagus nerve. Then detach the cranial neck preparation from the upper accessory triangle while protecting the nerve. Now successively detach the posterior neck preparation while protecting all plexus branches. Then complete the anterior neck level II, II, exposing the hypoglossal nerve. Then again bipolar bladder irrigation, hydrogen and Ringer irrigation. Insertion of a Redon drain and two-layer wound closure. Repositioning for neck dissection on the left: Instillation of 10 ml xylocaine with added adrenaline in the area of the anterior border of the sternocleidomastoid muscle. Palpation reveals a large, coarse lump in the depth of the neck. Curved skin incision in the area of the anterior edge of the sternocleidomastoid muscle. Exposure of the anterior edge. This goes approximately to the middle of the dissection seen from the caudal side, as the tumor is already infiltrating the musculature here. Now expose the lower border in the sense of the omohyoid muscle. Visualization of the jugular vein. It can be seen that it runs through the tumor block, with an extremely congested facial vein. Now laboriously locate the digaster muscle and successively release the tumor block in the upper accessorius triangle. The accessorius nerve can be exposed with great effort, as it runs through the tumor. However, it can be separated from the tumor while preserving a small displacement layer. Demonstration of the findings on and decision to leave the nerve in place. Now, with resection of parts of the sternocleidomastoid muscle, detachment of the tumor specimen laterally. Subsequent medial dissection. The tumor extends to the carotid artery with a clear displacement layer. As the jugular vein runs through the tumor, clamp it caudally and cranially, place 2 lower ligatures as well as 2 re-stitches and remove the vein. The tumor block can now be easily worked out after detachment from the vagus nerve. In between, a swab of tumor secretions is taken and sent for microbiological examination. Further excision of the tumor block with partial removal of plexus branches. The hypoglossal nerve has already been exposed due to dissection. The decision was made to ligate the external carotid artery. Identification of the same, visualization of the thyroid artery and the ascending lingual pharyngeal artery. The external carotid artery is then ligated. Then dissect up to the capsule of the submandibular gland and remove it. Follicularization of the anterior neck and irrigation with hydrogen and Ringer's solution. Minute bipolar hemostasis and insertion of a Redon drain. Then two-layer wound closure. Finally, another enoral check. Absolutely dry wound conditions here. Complication-free completion of the procedure. Patient receives 3 g Unacid i.v. intraoperatively. Please continue this antibiotic treatment 3 x daily for 4 days. \ No newline at end of file diff --git a/449/InvasionFront_CD3_block13_x3_y11_patient449_0.json b/449/InvasionFront_CD3_block13_x3_y11_patient449_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c41d95b0b12d87cf5ea9ed2668f02c1788f897b5 --- /dev/null +++ b/449/InvasionFront_CD3_block13_x3_y11_patient449_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10969.2, + "Centroid Y µm": 26560.9, + "Num Detections": 18381, + "Num Negative": 17872, + "Num Positive": 509, + "Positive %": 2.769, + "Num Positive per mm^2": 267.89 + } +} \ No newline at end of file diff --git a/449/InvasionFront_CD3_block13_x4_y11_patient449_1.json b/449/InvasionFront_CD3_block13_x4_y11_patient449_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd4139e388b9b07194d809404f3712136300349b --- /dev/null +++ b/449/InvasionFront_CD3_block13_x4_y11_patient449_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 26411.0, + "Num Detections": 10388, + "Num Negative": 9846, + "Num Positive": 542, + "Positive %": 5.218, + "Num Positive per mm^2": 506.36 + } +} \ No newline at end of file diff --git a/449/InvasionFront_CD8_block13_x3_y11_patient449_0.json b/449/InvasionFront_CD8_block13_x3_y11_patient449_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a80a9274d10f7b19e1ecede34dcab1789998a5fd --- /dev/null +++ b/449/InvasionFront_CD8_block13_x3_y11_patient449_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11419.0, + "Centroid Y µm": 28385.0, + "Num Detections": 21239, + "Num Negative": 20500, + "Num Positive": 739, + "Positive %": 3.479, + "Num Positive per mm^2": 358.88 + } +} \ No newline at end of file diff --git a/449/InvasionFront_CD8_block13_x4_y11_patient449_1.json b/449/InvasionFront_CD8_block13_x4_y11_patient449_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f9da4401c67d91590078b23f404b9c5dd3c77bec --- /dev/null +++ b/449/InvasionFront_CD8_block13_x4_y11_patient449_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14117.5, + "Centroid Y µm": 28559.9, + "Num Detections": 11695, + "Num Negative": 11268, + "Num Positive": 427, + "Positive %": 3.651, + "Num Positive per mm^2": 368.68 + } +} \ No newline at end of file diff --git a/449/TumorCenter_CD3_block13_x3_y11_patient449_0.json b/449/TumorCenter_CD3_block13_x3_y11_patient449_0.json new file mode 100644 index 0000000000000000000000000000000000000000..004ba49fcd7cf197d2babae2f93b29811be8464d --- /dev/null +++ b/449/TumorCenter_CD3_block13_x3_y11_patient449_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 33907.0, + "Num Detections": 21615, + "Num Negative": 16827, + "Num Positive": 4788, + "Positive %": 22.15, + "Num Positive per mm^2": 2200.1 + } +} \ No newline at end of file diff --git a/449/TumorCenter_CD3_block13_x4_y11_patient449_1.json b/449/TumorCenter_CD3_block13_x4_y11_patient449_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e5cfcb55dc96d682239042098bccf3edb0e5effc --- /dev/null +++ b/449/TumorCenter_CD3_block13_x4_y11_patient449_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 34131.9, + "Num Detections": 17328, + "Num Negative": 16232, + "Num Positive": 1096, + "Positive %": 6.325, + "Num Positive per mm^2": 634.54 + } +} \ No newline at end of file diff --git a/449/TumorCenter_CD8_block13_x3_y11_patient449_0.json b/449/TumorCenter_CD8_block13_x3_y11_patient449_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9752ba14e3ac8f2888d9528e03292c7b1842d305 --- /dev/null +++ b/449/TumorCenter_CD8_block13_x3_y11_patient449_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 27210.6, + "Num Detections": 19489, + "Num Negative": 18675, + "Num Positive": 814, + "Positive %": 4.177, + "Num Positive per mm^2": 455.75 + } +} \ No newline at end of file diff --git a/449/TumorCenter_CD8_block13_x4_y11_patient449_1.json b/449/TumorCenter_CD8_block13_x4_y11_patient449_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d65b6ad27259fd7244925a5c7cf772ed3235e7b --- /dev/null +++ b/449/TumorCenter_CD8_block13_x4_y11_patient449_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15791.6, + "Centroid Y µm": 26960.7, + "Num Detections": 16773, + "Num Negative": 16576, + "Num Positive": 197, + "Positive %": 1.175, + "Num Positive per mm^2": 129.98 + } +} \ No newline at end of file diff --git a/449/history_text.txt b/449/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a1b1940c4be6ea92df31782098b00039a735b1b1 --- /dev/null +++ b/449/history_text.txt @@ -0,0 +1 @@ +The patient has a condition after neck dissection on the left side and CUP panendoscopy <2017>, with cervical left-sided CUP syndrome. The patient did not undergo adjuvant radiochemotherapy. The follow-up examination revealed a contrast-enhancing mass at the base of the tongue on the left side. A bipsie was taken by panendoscopy and a p16-negative squamous cell carcinoma was diagnosed. There is now an indication for transoral tumor resection. The patient was informed in detail preoperatively and had sufficient time to ask questions. \ No newline at end of file diff --git a/449/icd_codes.txt b/449/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b2036d85a4fdd9a98ddb064ad51cfac440fcbdfc --- /dev/null +++ b/449/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung, primäre Lokalisation unbekannt, so bezeichnet[C80.0 ] Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/449/ops_codes.txt b/449/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56336672a8436ffd7dd31ac75f83633610e62c58 --- /dev/null +++ b/449/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Transorale Tumortonsillektomie[5-281.2 ] Partielle Glossektomie transoral Rekonstruktion mit nicht vaskularisiertem Transplantat[5-251.01 ] \ No newline at end of file diff --git a/449/patient_clinical_data.json b/449/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4739484205651571976242bca6f3b77f40aed0a3 --- /dev/null +++ b/449/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 76, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/449/patient_pathological_data.json b/449/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..466666cd38d0b999781ccf857b597c4971e5b8c2 --- /dev/null +++ b/449/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "449", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 1.5 +} \ No newline at end of file diff --git a/449/surgery_description.txt b/449/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4867fb0820a067c04f19685f19a23d9369ce09b3 --- /dev/null +++ b/449/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Tracheotomy, Protective tracheostomy diff --git a/449/surgery_report.txt b/449/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9cf3e99959b1ee09073795783209c8def266761c --- /dev/null +++ b/449/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating room. Carrying out the team time-out after active patient identification and initial consultation with the anesthesia colleagues. Induction of intubation anesthesia, bronchoscopically by the colleagues. Head positioning by the surgeon. Insertion of the spandex lip retractor and the covered retractor to open the mouth. Inspection of the oropharynx. In the previously described location in the area of the glossotonsillar groove on the left side, a tumor-suspicious ulcer can be seen with slight irregularity of the mucosa. The ulcer extends to the lateral wall of the oropharynx just below the upper pole of the tonsil. Extension of the ulcer of 0.5 x 0.5 cm. In addition, the lateral oropharyngeal wall is palpable. In addition, a palpable mass below the ulcer extending into the base of the tongue. It is decided to incise the area extensively with a safety margin of one cm. To do this, first make an incision in the area of the base of the tongue and carefully dissect with the ultracision knife. The preparation is made in healthy muscles. Dissection is carried out under constant coagulation of small blood vessels and palpatory control. Now also dissection laterally down to the lower jaw. Healthy tissue can be left on the lower jaw so that no bone is exposed. During dissection, the lingual nerve is exposed, which is looped and moved laterally. Now also detach the tumor from the cranial tonsil pole. Here, entry in the area of the anterior palatal arch and dissection of the tonsillar lobe. Incision of the posterior palatal arch and careful pushing of the resectate from the lateral oropharyngeal side wall. This exposes the parapharyngeal vessels, which are safely spared and dissected away from the tumor. A branch of the lingual artery is clipped. After removal of the tumor in the area of the base of the tongue, the lingual artery is exposed over a distance of approx. one cm. The resectate is then placed on the cork plate, marked with a needle and sent for a frozen section histological examination. After feedback from the pathology colleagues, the status is R0 with free resection margins. Bipolar hemostasis of several smaller bleedings in the area of the base of the tongue and the lateral oropharyngeal side wall is performed. The lateral oropharyngeal side wall is sutured over for vascular protection. In addition, wound adaptation of the edges of the tongue and base of tongue to cover the lingual artery. Due to the risk of bleeding, in consultation with , it was decided to create a protective tracheostoma. After tumor resection as described above, a protective tracheostoma is created. Repositioning and covering the patient. Marking of the thyroid cartilage, cricoid cartilage and jugulum. Easy palpation of the most important structures is possible. Now make a skin incision approx. 2 1/2 cm long and approx. 1 QF wide below the cricoid cartilage. Further dissection in depth with bipolar coagulation of the subcutaneous fatty tissue. Strict dissection along the median line through the prelaryngeal musculature. Intermittent bipolar coagulation of smaller vessels, now exposing the thyroid level. Undermining of the thyroid isthmus from cranial to caudal using a curved clamp, followed by extensive bipolar coagulation of the isthmus and transection using scissors. Blunt dissection and exposure of the trachea. Locate the area between the 2nd and 3rd cartilage clasp. Bipolar marking here for later incision. Now carefully open the trachea using pointed scissors, taking great care not to damage the cuff. Now create the anastomosis between the skin and trachea in the conventional manner. For this purpose, back-stitch suture using Vicryl 4.0 at two points caudally and cranially, laterally in each case. This is successful without any problems, resulting in an epithelialized tracheostoma. Withdrawal of the tube through the anesthesia and problem-free insertion of a size 8 tracheostomy tube. Subsequent intubation without complications and application of a wound dressing. The operation was completed under dry wound conditions. Summary: R0 resection of a cT1 cN0 oropharyngeal carcinoma in the area of the glossotonsillar groove on the left side. The resection margins are all tumor-free in the frozen section. Please present the case at our interdisciplinary tumor conference. Nutrition for 6 days via nasogastric tube. \ No newline at end of file diff --git a/450/InvasionFront_CD3_block17_x3_y6_patient450_0.json b/450/InvasionFront_CD3_block17_x3_y6_patient450_0.json new file mode 100644 index 0000000000000000000000000000000000000000..70896cfab52151907e3d108d443fccb75da34f77 --- /dev/null +++ b/450/InvasionFront_CD3_block17_x3_y6_patient450_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 20139.3, + "Num Detections": 20564, + "Num Negative": 19982, + "Num Positive": 582, + "Positive %": 2.83, + "Num Positive per mm^2": 264.04 + } +} \ No newline at end of file diff --git a/450/InvasionFront_CD3_block17_x4_y6_patient450_1.json b/450/InvasionFront_CD3_block17_x4_y6_patient450_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2bf8610b51b3240727dfad079b44f7df47dcb731 --- /dev/null +++ b/450/InvasionFront_CD3_block17_x4_y6_patient450_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 20239.3, + "Num Detections": 18130, + "Num Negative": 17396, + "Num Positive": 734, + "Positive %": 4.049, + "Num Positive per mm^2": 362.87 + } +} \ No newline at end of file diff --git a/450/InvasionFront_CD8_block17_x3_y6_patient450_0.json b/450/InvasionFront_CD8_block17_x3_y6_patient450_0.json new file mode 100644 index 0000000000000000000000000000000000000000..11189e081d6b2928685d7b0a2b285ea0986ec1fe --- /dev/null +++ b/450/InvasionFront_CD8_block17_x3_y6_patient450_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 15291.9, + "Num Detections": 20723, + "Num Negative": 20438, + "Num Positive": 285, + "Positive %": 1.375, + "Num Positive per mm^2": 129.85 + } +} \ No newline at end of file diff --git a/450/InvasionFront_CD8_block17_x4_y6_patient450_1.json b/450/InvasionFront_CD8_block17_x4_y6_patient450_1.json new file mode 100644 index 0000000000000000000000000000000000000000..adf146e96c3ea42e879ba539a7e130c4938a8eba --- /dev/null +++ b/450/InvasionFront_CD8_block17_x4_y6_patient450_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 15341.9, + "Num Detections": 17700, + "Num Negative": 16585, + "Num Positive": 1115, + "Positive %": 6.299, + "Num Positive per mm^2": 558.42 + } +} \ No newline at end of file diff --git a/450/TumorCenter_CD3_block17_x3_y6_patient450_0.json b/450/TumorCenter_CD3_block17_x3_y6_patient450_0.json new file mode 100644 index 0000000000000000000000000000000000000000..67a288579944858d34fe9415907205eb5a59517c --- /dev/null +++ b/450/TumorCenter_CD3_block17_x3_y6_patient450_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10969.2, + "Centroid Y µm": 14967.1, + "Num Detections": 17208, + "Num Negative": 15203, + "Num Positive": 2005, + "Positive %": 11.65, + "Num Positive per mm^2": 996.53 + } +} \ No newline at end of file diff --git a/450/TumorCenter_CD3_block17_x4_y6_patient450_1.json b/450/TumorCenter_CD3_block17_x4_y6_patient450_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9ba394061d39903a0847077add02b17140d7027 --- /dev/null +++ b/450/TumorCenter_CD3_block17_x4_y6_patient450_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 15017.0, + "Num Detections": 19942, + "Num Negative": 19762, + "Num Positive": 180, + "Positive %": 0.9026, + "Num Positive per mm^2": 79.66 + } +} \ No newline at end of file diff --git a/450/TumorCenter_CD8_block17_x3_y6_patient450_0.json b/450/TumorCenter_CD8_block17_x3_y6_patient450_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6696281bf8c2437f56d1821825168776984654e0 --- /dev/null +++ b/450/TumorCenter_CD8_block17_x3_y6_patient450_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 28734.8, + "Num Detections": 20363, + "Num Negative": 18401, + "Num Positive": 1962, + "Positive %": 9.635, + "Num Positive per mm^2": 863.46 + } +} \ No newline at end of file diff --git a/450/TumorCenter_CD8_block17_x4_y6_patient450_1.json b/450/TumorCenter_CD8_block17_x4_y6_patient450_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6aae37f76fda5576b0e3e710f1296fd51f81f37c --- /dev/null +++ b/450/TumorCenter_CD8_block17_x4_y6_patient450_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 28684.8, + "Num Detections": 19752, + "Num Negative": 19643, + "Num Positive": 109, + "Positive %": 0.5518, + "Num Positive per mm^2": 49.61 + } +} \ No newline at end of file diff --git a/450/history_text.txt b/450/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/450/icd_codes.txt b/450/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/450/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/450/ops_codes.txt b/450/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5427742d1c9f2b6adb2dff3caf0e918b9cea8366 --- /dev/null +++ b/450/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Mikrolaryngoskopie[1-610.2 ] Endolaryngeale Chordektomie[5-302.1 ] Chordektomie durch Stützlaryngoskopie[5-302.1 ] \ No newline at end of file diff --git a/450/patient_clinical_data.json b/450/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f177659271a1d27d38a1e1eec08eba068a262f74 --- /dev/null +++ b/450/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/450/patient_pathological_data.json b/450/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ff784d3c66b9f21e726e3dad6413b1139675dbb5 --- /dev/null +++ b/450/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "450", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.5 +} \ No newline at end of file diff --git a/450/surgery_description.txt b/450/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9ace2e5e4ebba8cedda28a913af118a29d8dd137 --- /dev/null +++ b/450/surgery_description.txt @@ -0,0 +1 @@ +Laser surgical chordectomy left, SL (Supraglottic Laryngectomy) up to the anterior commissure diff --git a/450/surgery_report.txt b/450/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c92679507fad3bc04802193d0a0a1c7aaba62367 --- /dev/null +++ b/450/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first adjust the glottic plane with the Kleinsasser B-tube. This works well despite the pronounced ankylosing spondylitis. Inspection of the glottis reveals the tumor located in the anterior region of the left vocal fold. This does not quite reach backwards to the vocal process. Ventrally, it already reaches the anterior commissure, but is still easily accessible transorally. Laser resection then begins with the CO2 laser at 4 watts in continuous wave mode. First, the tumor is cut approximately in the middle from medial to lateral and the dorsal part of the tumor is successively resected. This involves parts of the vocalis muscle, although the tumor does not appear to have grown particularly far into the tissue at this point. Resection extends posteriorly to the vocalis process. After removal of the dorsal part of the tumor, marginal samples are taken from the marginal areas, which are found to be free of tumor and dysplasia by frozen section pathology. Transition to resection of the anterior part of the tumor. For the sake of clarity, a narrow strip of mucosa is first resected in the supraglottis area, which extends to above the anterior commissure. This means that the lateral part of the tumor is also easily visible. Mobilizing the tumour medially, the lateral and deep parts are resected first. The anterior commissure is then included in the resection as well as the first 2 - 3 mm of the right vocal fold. The resection is performed down to the thyroid cartilage, where the tumor in the area of the anterior commissure is released and removed together with the perichondrium. The tumor is then removed from the anterior commissure, partly with a laser and partly bluntly. Finally, it can then be removed in toto with resection of the medial parts. Suture marking in the area of the anterior commissure. Here too, representative marginal samples are taken in turn and from the base of the tumor, which also prove to be free of tumor and dysplasia by frozen section pathology. Subsequently, careful hemostasis by monopolar coagulation and compression with adrenaline-containing cotton swabs until the blood is completely dry. Remove the instruments without damaging the teeth. Transfer of the patient to anesthesia. Completion of the operation. Transoral laser surgical laser resection of a T1 glottic laryngeal carcinoma on the left side in the sense of a chordectomy and inclusion of the anterior commissure. The resection margins were tumor-free on frozen section histology. Control laryngoscopy in 8 - 10 weeks. \ No newline at end of file diff --git a/451/InvasionFront_CD3_block21_x5_y2_patient451_0.json b/451/InvasionFront_CD3_block21_x5_y2_patient451_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6a22e15bad495118378cbf329bf3bbd4f8476cf2 --- /dev/null +++ b/451/InvasionFront_CD3_block21_x5_y2_patient451_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 15579.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/451/InvasionFront_CD3_block21_x6_y2_patient451_1.json b/451/InvasionFront_CD3_block21_x6_y2_patient451_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ef28da2e766fae909d66ccbeeea3ccfd6459b5a --- /dev/null +++ b/451/InvasionFront_CD3_block21_x6_y2_patient451_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21763.5, + "Centroid Y µm": 15791.6, + "Num Detections": 12555, + "Num Negative": 12536, + "Num Positive": 19, + "Positive %": 0.1513, + "Num Positive per mm^2": 8.804 + } +} \ No newline at end of file diff --git a/451/InvasionFront_CD8_block21_x5_y2_patient451_0.json b/451/InvasionFront_CD8_block21_x5_y2_patient451_0.json new file mode 100644 index 0000000000000000000000000000000000000000..642a1089edf1feae1441e5774e2e77d44a837d49 --- /dev/null +++ b/451/InvasionFront_CD8_block21_x5_y2_patient451_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15979.0, + "Centroid Y µm": 4834.9, + "Num Detections": 19729, + "Num Negative": 19434, + "Num Positive": 295, + "Positive %": 1.495, + "Num Positive per mm^2": 131.82 + } +} \ No newline at end of file diff --git a/451/InvasionFront_CD8_block21_x6_y2_patient451_1.json b/451/InvasionFront_CD8_block21_x6_y2_patient451_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f5af679e52a1c4e76704233664dfaf45b2b3b5a --- /dev/null +++ b/451/InvasionFront_CD8_block21_x6_y2_patient451_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18602.7, + "Centroid Y µm": 4785.0, + "Num Detections": 20024, + "Num Negative": 19949, + "Num Positive": 75, + "Positive %": 0.3746, + "Num Positive per mm^2": 29.85 + } +} \ No newline at end of file diff --git a/451/TumorCenter_CD3_block21_x5_y2_patient451_0.json b/451/TumorCenter_CD3_block21_x5_y2_patient451_0.json new file mode 100644 index 0000000000000000000000000000000000000000..65eb2176e6901bf593c61c1bf0d4748c506aa00a --- /dev/null +++ b/451/TumorCenter_CD3_block21_x5_y2_patient451_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16503.2, + "Centroid Y µm": 7064.1, + "Num Detections": 19421, + "Num Negative": 19342, + "Num Positive": 79, + "Positive %": 0.4068, + "Num Positive per mm^2": 34.51 + } +} \ No newline at end of file diff --git a/451/TumorCenter_CD3_block21_x6_y2_patient451_1.json b/451/TumorCenter_CD3_block21_x6_y2_patient451_1.json new file mode 100644 index 0000000000000000000000000000000000000000..842c40bd4c2ca99e9bebddf885787f8915595616 --- /dev/null +++ b/451/TumorCenter_CD3_block21_x6_y2_patient451_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19123.7, + "Centroid Y µm": 6855.8, + "Num Detections": 8275, + "Num Negative": 8221, + "Num Positive": 54, + "Positive %": 0.6526, + "Num Positive per mm^2": 58.46 + } +} \ No newline at end of file diff --git a/451/TumorCenter_CD8_block21_x5_y2_patient451_0.json b/451/TumorCenter_CD8_block21_x5_y2_patient451_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4e686dace7d1c732ec6e412a3dd377fa250a779a --- /dev/null +++ b/451/TumorCenter_CD8_block21_x5_y2_patient451_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19539.7, + "Centroid Y µm": 19764.5, + "Num Detections": 19957, + "Num Negative": 19779, + "Num Positive": 178, + "Positive %": 0.8919, + "Num Positive per mm^2": 77.0 + } +} \ No newline at end of file diff --git a/451/TumorCenter_CD8_block21_x6_y2_patient451_1.json b/451/TumorCenter_CD8_block21_x6_y2_patient451_1.json new file mode 100644 index 0000000000000000000000000000000000000000..241ade4321f991e751b9b49ecaf3bd2ffca76bfe --- /dev/null +++ b/451/TumorCenter_CD8_block21_x6_y2_patient451_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 22038.3, + "Centroid Y µm": 20014.4, + "Num Detections": 17389, + "Num Negative": 17179, + "Num Positive": 210, + "Positive %": 1.208, + "Num Positive per mm^2": 105.05 + } +} \ No newline at end of file diff --git a/451/history_text.txt b/451/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0059e1c8ae9d5e0b276e447cfcc382faf49b4029 --- /dev/null +++ b/451/history_text.txt @@ -0,0 +1 @@ +The patient had a history of multiple laser resections of a cT1a glottic carcinoma on the left and a history of vertical partial laryngectomy for recurrent glottic carcinoma in domo 2001. Currently histologically confirmed G2 squamous cell carcinoma recurrence in the anterior commissure and left paramedian region. Indication for fronto-lateral partial laryngectomy according to Leroux-Robert and placement of a tracheostoma in case of poor adjustability and rather circumscribed findings on computed tomography. \ No newline at end of file diff --git a/451/icd_codes.txt b/451/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3fc441e4d4825c4aa1cb2d74ab85b413db0db51b --- /dev/null +++ b/451/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 ] \ No newline at end of file diff --git a/451/ops_codes.txt b/451/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b70df3bf1cd11b061f3261a450ff2d4772d58275 --- /dev/null +++ b/451/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Temporäre Tracheotomie[5-311.0 ] Frontolaterale Kehlkopfteilresektion[5-302.7 ] \ No newline at end of file diff --git a/451/patient_clinical_data.json b/451/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b953065f409c602af5fd97378d7b39c75d008abf --- /dev/null +++ b/451/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 75, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "palliative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/451/patient_pathological_data.json b/451/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..82921f420e4f25e255a95334b74ab0d7ca9f7877 --- /dev/null +++ b/451/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "451", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/451/surgery_description.txt b/451/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..cd338afb02d029f74993f0b1c64f09a757f57e64 --- /dev/null +++ b/451/surgery_description.txt @@ -0,0 +1 @@ +Other partial laryngectomy: Partial resection, frontolateral (Leroux-Robert) diff --git a/451/surgery_report.txt b/451/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2353b18249915d545c9ceee6a1108bd176e77012 --- /dev/null +++ b/451/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia and frustrating bronchoscopic intubation by anesthesia colleagues. Positioning of the patient by the surgeon and performance of a rigid laryngoscopy using Kleinsasser-C. In the area of the anterior commissure, to the left paramedian side, an exophytic, contact-vulnerable, blood-stained mass was found, corresponding to the histologically confirmed G2 squamous cell carcinoma. There was a spread towards the anterior pocket fold on the left, the anterior right vocal fold was already affected by the tumorous mass. Thus classification rcT2. After removal of the Kleinsasser C-tube, repositioning of the patient. Injection of local anesthesia in the old surgical scar on the thyroid cartilage cavity. Skin spray disinfection, abjoration of the skin and sterile draping. Make a skin incision in the area of the old surgical scar approx. 4 cm through the subcutaneous tissue, expose and cut the prelarygeal muscles in the midline area. Push the prelaryngeal muscles to the side on both sides. Exposure of the thyroid cartilage. Closure of the perichondrium in the midline, pushing the perichondrium out of the anterior surface of the thyroid cartilage. Formation of a perichondrium flap. Performing a paramedian thyrotomy using a wire. Exposure of the inner perichondrium leaf and subperichondral dissection along the inner surface of the thyroid cartilage. Slit the endolaryngeal mucosa, initially cranially, thus entering the laryngeal lumen and inspecting the tumor from the cranial side. Successive incision of the endolaryngeal mucosa caudally and successive bypassing of the tumorous mass at the anterior commissure, including the anterior parts of the right vocal fold and the anterior 2/3 of the left vocal fold. The specimen is sent in for final histology marked with a thread (short short anterior commissure, short long supraglottic, long long subglottic). A post-resection in the supraglottic region is sent in thread-marked (short short posterior commissure, short long superior) and a third post-resection on the right vocal fold is sent in for final histology. Four marginal samples were taken (right vocal fold lower, right vocal fold upper, supraglottic posterior left and left vocal fold posterior). Intraoperative frozen section examination revealed mild to moderate dysplasia in the left posterior vocal fold margin specimen, otherwise all margin specimens were free of carcinoma. Hemostasis using pointed swabs soaked in hydrogen peroxide. Hemostasis using bipolar coagulation, suture adaptation of the supraglottic soft tissues on the severed thyroid cartilage leaves using Vicryl 2-0. Adaptation of both thyroid cartilage leaves using Vicryl 2-0. Drill holes created on both thyroid cartilage leaves using a Lindemann burr and fixation of a size 16 Keel foil at glottic level. Adaptation of the perichondrium flap to the outer surface of the thyroid cartilage. Readaptation of the prelaryngeal musculature in the midline. Creation of a flap. Two-layer wound closure, pressure dressing and subsequent performance of a plastic tracheotomy. Creation of an approx. 3 cm long incision along the old scar at the level of the lower edge of the cricoid cartilage. Entering the scarred tissue, hemostasis by bipolar coagulation. Exposure of the anterior tracheal wall, creation of an incision between the 2nd and 3rd tracheal cartilage clasp. Creation of a Björk flap and creation of tracheostomy sutures. Reintubation and insertion of an 8 mm Rügheimer cannula. Completion of the procedure without complications. The patient received intraoperative SDH 250 mg intravenously and clindamycin 600 mg intravenously. Please continue antibiotics for one week. \ No newline at end of file diff --git a/452/InvasionFront_CD3_block10_x5_y8_patient452_0.json b/452/InvasionFront_CD3_block10_x5_y8_patient452_0.json new file mode 100644 index 0000000000000000000000000000000000000000..435ea09ecd0e43e4cbb5f3d27e2117a986098942 --- /dev/null +++ b/452/InvasionFront_CD3_block10_x5_y8_patient452_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17783.5, + "Centroid Y µm": 26605.6, + "Num Detections": 26373, + "Num Negative": 15257, + "Num Positive": 11116, + "Positive %": 42.15, + "Num Positive per mm^2": 3957.7 + } +} \ No newline at end of file diff --git a/452/InvasionFront_CD3_block10_x6_y8_patient452_1.json b/452/InvasionFront_CD3_block10_x6_y8_patient452_1.json new file mode 100644 index 0000000000000000000000000000000000000000..95f06f2989ecceb59f3d5d57e756b3f44b0316e6 --- /dev/null +++ b/452/InvasionFront_CD3_block10_x6_y8_patient452_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20425.3, + "Centroid Y µm": 26893.5, + "Num Detections": 26017, + "Num Negative": 19006, + "Num Positive": 7011, + "Positive %": 26.95, + "Num Positive per mm^2": 2638.3 + } +} \ No newline at end of file diff --git a/452/InvasionFront_CD8_block10_x5_y8_patient452_0.json b/452/InvasionFront_CD8_block10_x5_y8_patient452_0.json new file mode 100644 index 0000000000000000000000000000000000000000..29f634f72f51189b2b05d59b7a185cee754befa2 --- /dev/null +++ b/452/InvasionFront_CD8_block10_x5_y8_patient452_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17790.6, + "Centroid Y µm": 26685.9, + "Num Detections": 24783, + "Num Negative": 19455, + "Num Positive": 5328, + "Positive %": 21.5, + "Num Positive per mm^2": 1986.0 + } +} \ No newline at end of file diff --git a/452/InvasionFront_CD8_block10_x6_y8_patient452_1.json b/452/InvasionFront_CD8_block10_x6_y8_patient452_1.json new file mode 100644 index 0000000000000000000000000000000000000000..96c250179a6acb7c61b73b318370d37dac374f6e --- /dev/null +++ b/452/InvasionFront_CD8_block10_x6_y8_patient452_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20539.1, + "Centroid Y µm": 26511.0, + "Num Detections": 25770, + "Num Negative": 21311, + "Num Positive": 4459, + "Positive %": 17.3, + "Num Positive per mm^2": 1743.4 + } +} \ No newline at end of file diff --git a/452/TumorCenter_CD3_block10_x5_y8_patient452_0.json b/452/TumorCenter_CD3_block10_x5_y8_patient452_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c98adfb43b7cfeb9df5ef1e9729e90574edc3fc1 --- /dev/null +++ b/452/TumorCenter_CD3_block10_x5_y8_patient452_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 19814.5, + "Num Detections": 26643, + "Num Negative": 22593, + "Num Positive": 4050, + "Positive %": 15.2, + "Num Positive per mm^2": 1509.2 + } +} \ No newline at end of file diff --git a/452/TumorCenter_CD3_block10_x6_y8_patient452_1.json b/452/TumorCenter_CD3_block10_x6_y8_patient452_1.json new file mode 100644 index 0000000000000000000000000000000000000000..10df99413981893804f5fbbe2f36e3899eb72b23 --- /dev/null +++ b/452/TumorCenter_CD3_block10_x6_y8_patient452_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21588.6, + "Centroid Y µm": 19889.5, + "Num Detections": 20438, + "Num Negative": 18476, + "Num Positive": 1962, + "Positive %": 9.6, + "Num Positive per mm^2": 836.83 + } +} \ No newline at end of file diff --git a/452/TumorCenter_CD8_block10_x5_y8_patient452_0.json b/452/TumorCenter_CD8_block10_x5_y8_patient452_0.json new file mode 100644 index 0000000000000000000000000000000000000000..813496f6308fc3bd960be96ac80fdcdac762d527 --- /dev/null +++ b/452/TumorCenter_CD8_block10_x5_y8_patient452_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 20414.2, + "Num Detections": 24054, + "Num Negative": 14234, + "Num Positive": 9820, + "Positive %": 40.82, + "Num Positive per mm^2": 3616.4 + } +} \ No newline at end of file diff --git a/452/TumorCenter_CD8_block10_x6_y8_patient452_1.json b/452/TumorCenter_CD8_block10_x6_y8_patient452_1.json new file mode 100644 index 0000000000000000000000000000000000000000..18b902bf224451368a7301ff704f712f2b663d49 --- /dev/null +++ b/452/TumorCenter_CD8_block10_x6_y8_patient452_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 20414.2, + "Num Detections": 21947, + "Num Negative": 18654, + "Num Positive": 3293, + "Positive %": 15.0, + "Num Positive per mm^2": 1342.4 + } +} \ No newline at end of file diff --git a/452/history_text.txt b/452/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7472fa68051b9b36026cede7e9ab780e7037d2a8 --- /dev/null +++ b/452/history_text.txt @@ -0,0 +1 @@ +The patient has had a progressive, dolent mass on the right cervical side for several weeks. \ No newline at end of file diff --git a/452/icd_codes.txt b/452/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e122b656265241d455eb47f3d6a7ee8893131639 --- /dev/null +++ b/452/icd_codes.txt @@ -0,0 +1 @@ +Branchiogene(r) Sinus, Fistel und Zyste[Q18.0 ] \ No newline at end of file diff --git a/452/ops_codes.txt b/452/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e5bac6d08f405af684dd3d6d037ad41a4578978c --- /dev/null +++ b/452/ops_codes.txt @@ -0,0 +1 @@ +Exstirpation einer lateralen Halszyste[5-291.1 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 2 Regionen[5-403.01 R] Tonsillektomie mit Dissektionstechnik[5-281.0 ] \ No newline at end of file diff --git a/452/patient_clinical_data.json b/452/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ca6acccf51513904874d82c65b311d95201946c1 --- /dev/null +++ b/452/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 72, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/452/patient_pathological_data.json b/452/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cd3e36cff762f0131d6ce70d2ec9649a76669ff4 --- /dev/null +++ b/452/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "452", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 4, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/452/surgery_description.txt b/452/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..50312bf02ac9be42bdb574ea1e368d8a571c1efe --- /dev/null +++ b/452/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Neck dissection diff --git a/452/surgery_report.txt b/452/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4eca5466b8815f0cc9897d96c4d218d0e43fb18e --- /dev/null +++ b/452/surgery_report.txt @@ -0,0 +1 @@ +After positioning the patient, first turn to extirpation of the cystic mass on the right cervical side. Sonographic evidence of a lateral cervical cyst. The palpable mass is well displaceable in levels II to III. Overall obese patient with a short neck, extremely unfavorable anatomical conditions. Skin incision along a skin fold, approx. 2 transverse fingers submandibular. Cut through skin and subcutaneous tissue. Exposure and transection of the platysma. Ample subcutaneous fatty tissue. Partial resection of the fatty tissue. Exposure of the anterior border of the sternocleidomastoid muscle. Here one encounters a cystic mass which appears to lie lateral to the internal jugular vein. Overall cystic mass, but some patchy changes in the mass. Overall neck cyst possible, but not an absolutely typical finding. Successive triggering of the cystic mass. Involvement of surrounding lymphatic tissue. The mass is located directly on the jugular vein and laterally. Circumscribed treatment and exposure of the superior artery. Extirpation of the cystic mass in toto. Careful wound inspection and, if the wound is dry, irrigation with H2O2 and Ringer's solution. Subsequent careful, two-layer wound closure after insertion of an 8-gauge Redon drain. Repositioning for tonsillectomy on the right. Entry with the tonsil retractor. Inspection of the tonsillar lobes. These are symmetrical with cryptic and rather small tonsils. Entering the anterior upper palatal arch. Exposure of the tonsil capsule. Removal of the macroscopically inconspicuous tonsil using the dissection technique. Protection of the parauvular mucosal triangle. Detachment from the posterior palatal arch with careful protection of the musculature and placement at the lower tonsil pole. Targeted treatment of the upper and lower tonsil pole. Final wound inspection if the wound is dry. Completion of the procedure without any indication of complications. Conclusion: Cystic mass on the right cervical side, lateral neck cyst possible. Possible differential diagnoses quite conceivable. \ No newline at end of file diff --git a/453/InvasionFront_CD3_block15_x3_y5_patient453_0.json b/453/InvasionFront_CD3_block15_x3_y5_patient453_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f3c9dc140a2249aa3f666eedfaef728f8d0e10f --- /dev/null +++ b/453/InvasionFront_CD3_block15_x3_y5_patient453_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13218.0, + "Centroid Y µm": 22463.1, + "Num Detections": 18502, + "Num Negative": 18173, + "Num Positive": 329, + "Positive %": 1.778, + "Num Positive per mm^2": 142.63 + } +} \ No newline at end of file diff --git a/453/InvasionFront_CD3_block15_x4_y5_patient453_1.json b/453/InvasionFront_CD3_block15_x4_y5_patient453_1.json new file mode 100644 index 0000000000000000000000000000000000000000..18d44bc73aa5b5ec5c3f16a515489d9c164126af --- /dev/null +++ b/453/InvasionFront_CD3_block15_x4_y5_patient453_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 22388.1, + "Num Detections": 15450, + "Num Negative": 12589, + "Num Positive": 2861, + "Positive %": 18.52, + "Num Positive per mm^2": 1660.6 + } +} \ No newline at end of file diff --git a/453/InvasionFront_CD8_block15_x3_y5_patient453_0.json b/453/InvasionFront_CD8_block15_x3_y5_patient453_0.json new file mode 100644 index 0000000000000000000000000000000000000000..85951a05c185f2db966dd516d8548d6e0fb93af6 --- /dev/null +++ b/453/InvasionFront_CD8_block15_x3_y5_patient453_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11216.3, + "Centroid Y µm": 12176.5, + "Num Detections": 10817, + "Num Negative": 10603, + "Num Positive": 214, + "Positive %": 1.978, + "Num Positive per mm^2": 146.53 + } +} \ No newline at end of file diff --git a/453/InvasionFront_CD8_block15_x4_y5_patient453_1.json b/453/InvasionFront_CD8_block15_x4_y5_patient453_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aa9554172c7f65549c99dfeed756334ab4f6f664 --- /dev/null +++ b/453/InvasionFront_CD8_block15_x4_y5_patient453_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 12263.6, + "Num Detections": 10809, + "Num Negative": 8710, + "Num Positive": 2099, + "Positive %": 19.42, + "Num Positive per mm^2": 1563.3 + } +} \ No newline at end of file diff --git a/453/TumorCenter_CD3_block15_x3_y5_patient453_0.json b/453/TumorCenter_CD3_block15_x3_y5_patient453_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8d6618cda82a504f54f38daa8cb66bce3fdcd5a3 --- /dev/null +++ b/453/TumorCenter_CD3_block15_x3_y5_patient453_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11294.0, + "Centroid Y µm": 15791.6, + "Num Detections": 22407, + "Num Negative": 18480, + "Num Positive": 3927, + "Positive %": 17.53, + "Num Positive per mm^2": 1479.3 + } +} \ No newline at end of file diff --git a/453/TumorCenter_CD3_block15_x4_y5_patient453_1.json b/453/TumorCenter_CD3_block15_x4_y5_patient453_1.json new file mode 100644 index 0000000000000000000000000000000000000000..026d5043da5cbf8202890dcb6f5c5f21588c5768 --- /dev/null +++ b/453/TumorCenter_CD3_block15_x4_y5_patient453_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 15866.6, + "Num Detections": 21283, + "Num Negative": 16992, + "Num Positive": 4291, + "Positive %": 20.16, + "Num Positive per mm^2": 1593.2 + } +} \ No newline at end of file diff --git a/453/TumorCenter_CD8_block15_x3_y5_patient453_0.json b/453/TumorCenter_CD8_block15_x3_y5_patient453_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d705c93de28f11adcaf1735e4809d7e2737a1588 --- /dev/null +++ b/453/TumorCenter_CD8_block15_x3_y5_patient453_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 12418.4, + "Num Detections": 20446, + "Num Negative": 16963, + "Num Positive": 3483, + "Positive %": 17.04, + "Num Positive per mm^2": 1340.5 + } +} \ No newline at end of file diff --git a/453/TumorCenter_CD8_block15_x4_y5_patient453_1.json b/453/TumorCenter_CD8_block15_x4_y5_patient453_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf110fc312c7d7a234e240036db59b50fe57c7e4 --- /dev/null +++ b/453/TumorCenter_CD8_block15_x4_y5_patient453_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 12493.4, + "Num Detections": 20749, + "Num Negative": 17231, + "Num Positive": 3518, + "Positive %": 16.96, + "Num Positive per mm^2": 1327.3 + } +} \ No newline at end of file diff --git a/453/history_text.txt b/453/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/453/icd_codes.txt b/453/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1e606991e24b100a31c551bf9b1c9ce71581d211 --- /dev/null +++ b/453/icd_codes.txt @@ -0,0 +1 @@ +Dorsaler Zungenkrebs[C02.0 R] \ No newline at end of file diff --git a/453/ops_codes.txt b/453/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9745c90943ae2c258e2d9fce359b66fda927b04a --- /dev/null +++ b/453/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 2 Regionen[5-403.01 L] Permanente Tracheotomie[5-312.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/453/patient_clinical_data.json b/453/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3014027ae16727fa43017dd31e014fe8138fd799 --- /dev/null +++ b/453/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 61, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/453/patient_pathological_data.json b/453/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..41d505b36636deaab19b29fefd19a9e44e2a52fe --- /dev/null +++ b/453/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "453", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/453/surgery_description.txt b/453/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d37c98d2027c4e3beba5bd5e94d4bae2188087b --- /dev/null +++ b/453/surgery_description.txt @@ -0,0 +1 @@ +Resection, Selective bilateral neck dissection, and Tracheotomy diff --git a/453/surgery_report.txt b/453/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4c7a364f32ff553cc0fa79b6cdc1368eb9cbfa04 --- /dev/null +++ b/453/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. First positioning of the patient for transoral tumor resection. Insertion of the mouth retractor. Subsequent marking of the margins. The tumor extends from the middle of the tongue body at the edge of the tongue to the base of the tongue and passes over to the glossotonsillar groove. Here it still partially infiltrates the anterior gauemnian arch. Medially, the tumor extends to approximately the middle of the tongue. Therefore, the first step is to approach the tumor and resect it with the Harmonic ultrasonic knife. The resection is performed under constant visual control and at a sufficient distance from the tumor. Larger vessels are ligated during resection. Follow the tumor dorsally. Detachment of the tumor at the palatal arch. Here resection of the glossotonsillar groove on the right side. Further tracing of the tumor at the medial edge of the deposit in a dorsal direction. This shows a cone that extends beyond the midline. This cone is also cut around and the tumor is removed in toto together with the base of the tongue on the right side. At a point where the tumor has formed the cone medially, the specimen is marked with a suture and sent for frozen section diagnostics. The tumor is barely resected in sano, which is why an additional safety margin is resected from the medial tongue body. Two representative frozen section samples are taken in the area of the margin of the floor of the mouth and palatal arch to ensure R0 resection. These are also sent for intraoperative frozen section diagnostics and are found to be tumor-free. Subtle hemostasis. Repositioning of the patient for PEG insertion. First, insertion of the flexible instrument into the esophagus and visualization up to the stomach. After filling the stomach with air, a positive diaphanoscopy is obtained. Then place the gastric tube in the typical location under visual control, with positive diaphanoscopy and positive tent phenomenon using the thread pull-through method. After aspiration of the insufflated air, mirror back and carefully inspect the esophageal mucosa, which is also non-irritant and inconspicuous. Removal of the instruments. The patient is repositioned for tracheotomy. This is necessary due to the extent of the tumor. Tracheotomy: First injection of local anesthetic with adrenaline on both sides of the neck in preparation for neck dissection and pretracheally. Inverted T-incision and layered preparation in depth. Finding the midline. Dissection of the musculature, which is dissected away to the side. Exposure of the thyroid isthmus. Exposing the lower edge of the cricoid cartilage. Undermining of the thyroid isthmus on both sides, .................................... is ligated. Separation of the isthmus in the midline and exposure of the anterior surface of the trachea. Opening of the trachea between the 2nd and 3rd cartilage clasp and preparation of a Björk flap. Subsequent circular suturing of the trachea in the sense of an epithelialized tracheotomy. The patient was then intubated and a size 7 tracheostomy tube was inserted. The patient was repositioned for neck dissection, initially on the right side. Incision along the sternocleidomastoid muscle. Dissection in depth in layers after cutting through the platysma. Exposure of the cervical vascular sheath and the omohyoid muscle. Exposure of the digaster muscle. This reveals a large conglomerate of lymph nodes in the area of the venous angle. Numerous other lymph nodes can be found in the lateral neck preparation. First expose the cervical vascular sheath. Long-distance dissection of the vagus nerve, which is lifted out of its bed in the sense of a neurolysis and moved medially in a long distance. Re-embedding of the nerve here. Subsequent exposure of the accessory nerve and dissection of the lateral neck preparation of levels II, III, IV and V. Dissection of the anterior neck preparation with preservation of the branches of the internal jugular vein and the external carotid artery. Clearing of the hypoglossal triangle. Long dissection of the nerve and neurolysis. Re-embedding of the nerve after cranial displacement. Exposure of the submandibular capsule. This is subtotally removed. Subsequent exposure of the gland. Preservation of the facial artery and vein after they are first dissected away from the gland. The supplying vessels are cut off. The gland is then detached from the glandular bed. Circular dissection of the gland and exposure of the uncinate process and the excretory duct. Ligation of the excretory duct and subsequent removal of the gland. A tiny defect is revealed in the area of the posterior floor of the mouth, which is generously sutured over with floor of mouth muscles. Taping of the suture with TachoSil. Overall, the neck dissection of the right side revealed numerous suspicious nodules in the five levels. Irrigation of the wound and repeated palpation, whereupon no more enlarged lymph nodes were palpated. Insertion of a Redon drain and two-layer wound closure. Application of a pressure bandage. Transition to the left side: Here, an arc-shaped skin incision is made along a neck fold. Here too, layer-by-layer dissection in depth after cutting through the platysma. Exposure of the cervical vascular sheath and long dissection of the vagus nerve. Neurolysis, displacement and re-embedding of the nerve. Clearing of the hypoglossal triangle after a small lymph node conglomerate is also revealed here. Long-term exposure Dissection of the hpyoglossal nerve, which is also re-embedded after neurolysis and cranial displacement. The accessorius nerve is also exposed. This is also dissected over a long distance and relocated after neurolysis. Re-embedding of the accessory nerve. Dissection of levels II and III, which are completely dissected. Subtle hemostasis. Irrigation of the wound. Insertion of a Redon drain. Two-layer wound closure. Application of a pressure bandage. Repositioning of the patient and enoral wound control. Subtle hemostasis again. The defect cannot be identified here. To prevent a fistula here, TachoSil is still applied to the posterior floor of the mouth. The TachoSil is fixed in place with a ball swab that is sewn on. If the wound is dry, the procedure is completed. Final consultation with the anesthetist. \ No newline at end of file diff --git a/454/InvasionFront_CD3_block12_x3_y10_patient454_0.json b/454/InvasionFront_CD3_block12_x3_y10_patient454_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ef874090c98c5ad2717fece5daf808c56d46d613 --- /dev/null +++ b/454/InvasionFront_CD3_block12_x3_y10_patient454_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10619.4, + "Centroid Y µm": 29584.3, + "Num Detections": 18443, + "Num Negative": 17779, + "Num Positive": 664, + "Positive %": 3.6, + "Num Positive per mm^2": 291.58 + } +} \ No newline at end of file diff --git a/454/InvasionFront_CD3_block12_x4_y10_patient454_1.json b/454/InvasionFront_CD3_block12_x4_y10_patient454_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fc1de9f3701e571d7a15f58674ebcdebaae5080b --- /dev/null +++ b/454/InvasionFront_CD3_block12_x4_y10_patient454_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13193.0, + "Centroid Y µm": 29809.2, + "Num Detections": 18256, + "Num Negative": 17390, + "Num Positive": 866, + "Positive %": 4.744, + "Num Positive per mm^2": 380.7 + } +} \ No newline at end of file diff --git a/454/InvasionFront_CD8_block12_x3_y10_patient454_0.json b/454/InvasionFront_CD8_block12_x3_y10_patient454_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9355d71f8c9074f0abb1c09920b63f5c96ecefdf --- /dev/null +++ b/454/InvasionFront_CD8_block12_x3_y10_patient454_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12593.3, + "Centroid Y µm": 28859.7, + "Num Detections": 19175, + "Num Negative": 19008, + "Num Positive": 167, + "Positive %": 0.8709, + "Num Positive per mm^2": 70.68 + } +} \ No newline at end of file diff --git a/454/InvasionFront_CD8_block12_x4_y10_patient454_1.json b/454/InvasionFront_CD8_block12_x4_y10_patient454_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c2b31c6c21b39717a3c511d737659291f79f62c6 --- /dev/null +++ b/454/InvasionFront_CD8_block12_x4_y10_patient454_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15167.0, + "Centroid Y µm": 28809.7, + "Num Detections": 16078, + "Num Negative": 15808, + "Num Positive": 270, + "Positive %": 1.679, + "Num Positive per mm^2": 130.74 + } +} \ No newline at end of file diff --git a/454/TumorCenter_CD3_block12_x3_y10_patient454_0.json b/454/TumorCenter_CD3_block12_x3_y10_patient454_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7c7ca58fb96d70824607f103e844572a7ad6cc1b --- /dev/null +++ b/454/TumorCenter_CD3_block12_x3_y10_patient454_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10469.5, + "Centroid Y µm": 24786.9, + "Num Detections": 14406, + "Num Negative": 13333, + "Num Positive": 1073, + "Positive %": 7.448, + "Num Positive per mm^2": 526.88 + } +} \ No newline at end of file diff --git a/454/TumorCenter_CD3_block12_x4_y10_patient454_1.json b/454/TumorCenter_CD3_block12_x4_y10_patient454_1.json new file mode 100644 index 0000000000000000000000000000000000000000..00ca826e10618079c16bcee82b2e923297960a6a --- /dev/null +++ b/454/TumorCenter_CD3_block12_x4_y10_patient454_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12993.1, + "Centroid Y µm": 24886.8, + "Num Detections": 15769, + "Num Negative": 13968, + "Num Positive": 1801, + "Positive %": 11.42, + "Num Positive per mm^2": 846.46 + } +} \ No newline at end of file diff --git a/454/TumorCenter_CD8_block12_x3_y10_patient454_0.json b/454/TumorCenter_CD8_block12_x3_y10_patient454_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d86c838a92d45470f5315441e579d2e176be738e --- /dev/null +++ b/454/TumorCenter_CD8_block12_x3_y10_patient454_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 34032.0, + "Num Detections": 14472, + "Num Negative": 14467, + "Num Positive": 5, + "Positive %": 0.0345, + "Num Positive per mm^2": 2.484 + } +} \ No newline at end of file diff --git a/454/TumorCenter_CD8_block12_x4_y10_patient454_1.json b/454/TumorCenter_CD8_block12_x4_y10_patient454_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e9b089897b1f1593cbacac8c1ff7b9924361a6c6 --- /dev/null +++ b/454/TumorCenter_CD8_block12_x4_y10_patient454_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 34281.8, + "Num Detections": 15526, + "Num Negative": 15505, + "Num Positive": 21, + "Positive %": 0.1353, + "Num Positive per mm^2": 10.29 + } +} \ No newline at end of file diff --git a/454/history_text.txt b/454/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/454/icd_codes.txt b/454/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/454/ops_codes.txt b/454/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/454/patient_clinical_data.json b/454/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..90e8f8ae732b6faf1f16d786f4dc29537988480a --- /dev/null +++ b/454/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 47, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/454/patient_pathological_data.json b/454/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3f263eafed61a35e3b3548666395f5822c21c4a5 --- /dev/null +++ b/454/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "454", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 35, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/454/surgery_description.txt b/454/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d5c9a4f2066c98aca60a5bd55f5965f0685895d8 --- /dev/null +++ b/454/surgery_description.txt @@ -0,0 +1 @@ +Resection of right tongue margin, PEG placement, Modified radical neck dissection bilaterally, Tracheostomy creation diff --git a/454/surgery_report.txt b/454/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/455/InvasionFront_CD3_block2_x3_y12_patient455_0.json b/455/InvasionFront_CD3_block2_x3_y12_patient455_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0b722ce756692ea3dc3938389a07634af37faae5 --- /dev/null +++ b/455/InvasionFront_CD3_block2_x3_y12_patient455_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13268.0, + "Centroid Y µm": 43477.0, + "Num Detections": 22642, + "Num Negative": 22383, + "Num Positive": 259, + "Positive %": 1.144, + "Num Positive per mm^2": 105.61 + } +} \ No newline at end of file diff --git a/455/InvasionFront_CD3_block2_x4_y12_patient455_1.json b/455/InvasionFront_CD3_block2_x4_y12_patient455_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ef193f93edf8c96bd7696ebe9be5e85619ce5fbb --- /dev/null +++ b/455/InvasionFront_CD3_block2_x4_y12_patient455_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15791.6, + "Centroid Y µm": 43601.9, + "Num Detections": 20006, + "Num Negative": 19833, + "Num Positive": 173, + "Positive %": 0.8647, + "Num Positive per mm^2": 76.44 + } +} \ No newline at end of file diff --git a/455/InvasionFront_CD8_block2_x3_y12_patient455_0.json b/455/InvasionFront_CD8_block2_x3_y12_patient455_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0687c38ae840a73f0090e30fd147e81c8c42c51c --- /dev/null +++ b/455/InvasionFront_CD8_block2_x3_y12_patient455_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11968.7, + "Centroid Y µm": 31033.6, + "Num Detections": 20235, + "Num Negative": 20063, + "Num Positive": 172, + "Positive %": 0.85, + "Num Positive per mm^2": 77.63 + } +} \ No newline at end of file diff --git a/455/InvasionFront_CD8_block2_x4_y12_patient455_1.json b/455/InvasionFront_CD8_block2_x4_y12_patient455_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a20bd44eb41bc3688a7f9306698d7b5260705c59 --- /dev/null +++ b/455/InvasionFront_CD8_block2_x4_y12_patient455_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14617.3, + "Centroid Y µm": 31158.5, + "Num Detections": 20090, + "Num Negative": 19896, + "Num Positive": 194, + "Positive %": 0.9657, + "Num Positive per mm^2": 89.65 + } +} \ No newline at end of file diff --git a/455/TumorCenter_CD3_block2_x3_y12_patient455_0.json b/455/TumorCenter_CD3_block2_x3_y12_patient455_0.json new file mode 100644 index 0000000000000000000000000000000000000000..206b14e6281149b59e5570f7e7090cbafe8da57e --- /dev/null +++ b/455/TumorCenter_CD3_block2_x3_y12_patient455_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10594.4, + "Centroid Y µm": 29484.4, + "Num Detections": 18201, + "Num Negative": 17964, + "Num Positive": 237, + "Positive %": 1.302, + "Num Positive per mm^2": 106.75 + } +} \ No newline at end of file diff --git a/455/TumorCenter_CD3_block2_x4_y12_patient455_1.json b/455/TumorCenter_CD3_block2_x4_y12_patient455_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f3cab894d12babbbd236375980bbded506ee4ade --- /dev/null +++ b/455/TumorCenter_CD3_block2_x4_y12_patient455_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13043.1, + "Centroid Y µm": 29609.3, + "Num Detections": 20659, + "Num Negative": 20497, + "Num Positive": 162, + "Positive %": 0.7842, + "Num Positive per mm^2": 69.29 + } +} \ No newline at end of file diff --git a/455/TumorCenter_CD8_block2_x3_y12_patient455_0.json b/455/TumorCenter_CD8_block2_x3_y12_patient455_0.json new file mode 100644 index 0000000000000000000000000000000000000000..09aadff47ffec3868745604623fe8f8cd940dd4b --- /dev/null +++ b/455/TumorCenter_CD8_block2_x3_y12_patient455_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 29634.3, + "Num Detections": 17351, + "Num Negative": 17041, + "Num Positive": 310, + "Positive %": 1.787, + "Num Positive per mm^2": 143.42 + } +} \ No newline at end of file diff --git a/455/TumorCenter_CD8_block2_x4_y12_patient455_1.json b/455/TumorCenter_CD8_block2_x4_y12_patient455_1.json new file mode 100644 index 0000000000000000000000000000000000000000..396b9d1d7bd1095582e9ed18a47cfbafe7f86994 --- /dev/null +++ b/455/TumorCenter_CD8_block2_x4_y12_patient455_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 29609.3, + "Num Detections": 18550, + "Num Negative": 18429, + "Num Positive": 121, + "Positive %": 0.6523, + "Num Positive per mm^2": 60.67 + } +} \ No newline at end of file diff --git a/455/history_text.txt b/455/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..bd1b742150a3253af8fa30e80d041b2b64a06faf --- /dev/null +++ b/455/history_text.txt @@ -0,0 +1 @@ +The patient is suspected of having a neoplasm in the area of the hard and soft palate on the left side. In addition, there is a suspicion of an ear canal cholesteatoma on the right. The above-mentioned procedure should therefore be performed. \ No newline at end of file diff --git a/455/icd_codes.txt b/455/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..961e753a25d27fa32006d1b6e6e39b813610a530 --- /dev/null +++ b/455/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Gaumen, mehrere Teilbereiche überlappend[C05.8 ] Cholesteatom im äußeren Ohr[H60.4 ] \ No newline at end of file diff --git a/455/ops_codes.txt b/455/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..90846a839a81f4e7c87678bef1de9a643aeaeb65 --- /dev/null +++ b/455/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie: Bei normalem Situs[1-631.0 ] Inzision, Exzision und Destruktion in der Mundhöhle: Sonstige[5-273.x L] Exzision und Destruktion von erkranktem Gewebe des äußeren Ohres: Exzision und Destruktion am knöchernen äußeren Gehörgang[5-181.9 R] Konstruktion und Rekonstruktion des äußeren Gehörganges: Erweiterung (z.B. bei Gehörgangsstenose)[5-185.0 R] Konstruktion und Rekonstruktion des äußeren Gehörganges: Rekonstruktion eines (bestehenden) äußeren Gehörganges[5-185.2 R] Andere Operationen am äußeren Ohr: Entnahme von Ohrknorpel zur Transplantation[5-189.0 R] \ No newline at end of file diff --git a/455/patient_clinical_data.json b/455/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fee29b1295c230f9fdb9a392e66074a692f4c1ad --- /dev/null +++ b/455/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/455/patient_pathological_data.json b/455/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7a475a52fcb937e78cac1008579fbd24c0c0cb7d --- /dev/null +++ b/455/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "455", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/455/surgery_description.txt b/455/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..996110a86cc8cf6c23a04e7c526b63e569197f93 --- /dev/null +++ b/455/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy with laser diff --git a/455/surgery_report.txt b/455/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8973c3fa4052d8e3c61f1c202c0fdb84e8d93ebd --- /dev/null +++ b/455/surgery_report.txt @@ -0,0 +1 @@ +First of all, a consultation with the anesthetist. And after induction of anesthesia, tracheoscopy and inspection of the endolarynx up to the bifurcation. Inconspicuous conditions here. No indication of mucosal irregularities. After intubation, perform hypopharyngoscopy, microlaryngoscopy and pharyngoscopy. In each case, the findings were unremarkable except for the prescribed lesion approx. 1 cm in size in the area of the hard palate, which then had extensions of reddish altered mucosa to the soft palate. After another flexible gastroesophagoscopy has been performed, which reveals an inflamed mucosa in the stomach, the local erosion is then successively dissected out with the CO2 laser and the handpiece with 10 watts of power in the case of suspected neoplasia in the sense of an excision biopsy. This works well. Suture marking with a short-short suture marker for the front and a long-long suture marker for the side. The preparation is sent for final histology. Now, after careful hemostasis, repositioning for ear surgery on the right side. After sterile draping, an auxiliary incision and counter-incision are made. Overall very heavy bleeding in the patient, who is under heparinization and has low thrombocytes of 80,000. This bleeding made the operation considerably more difficult. Due to a history of coronary heart disease, it is unfortunately not possible to inject xylocaine or lidocaine with added adrenaline. After further careful hemostasis, a Stacke II flap is developed and the cholesteatoma originating in the anterior wall is exposed in the auditory canal. This is cut around in a circular fashion. The skin of the auditory canal is then dissected to form an anterior tympanomeatal flap and the cholesteatoma sac is completely released. This is also successful. At the same time, a bony stenosis of the ear canal is revealed, so that this is partially drilled away with the diamond drill very carefully and with great difficulty in order to protect the anterior tympanomeatal flap, which continues to bleed. This also works well. Better view towards the tympanic membrane. Tragus cartilage is now removed. Careful hemostasis here too. The tragus cartilage is then inserted as a cartilage perichondrium plate to reconstruct the anterior wall of the auditory canal. In addition, perichondrium is placed over it to equalize the level of the remaining ear canal skin. Filling of the ear canal with vibravenous gel. Suture of the auxiliary incision. Ointment strip tamponade and, after consultation with the anesthesiologist, completion of the procedure. \ No newline at end of file diff --git a/456/InvasionFront_CD3_block13_x3_y12_patient456_0.json b/456/InvasionFront_CD3_block13_x3_y12_patient456_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c245747595a4ca5904d581051f75eeab55bb8796 --- /dev/null +++ b/456/InvasionFront_CD3_block13_x3_y12_patient456_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 28934.7, + "Num Detections": 18153, + "Num Negative": 16795, + "Num Positive": 1358, + "Positive %": 7.481, + "Num Positive per mm^2": 554.68 + } +} \ No newline at end of file diff --git a/456/InvasionFront_CD3_block13_x4_y12_patient456_1.json b/456/InvasionFront_CD3_block13_x4_y12_patient456_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b504ccfba6f03ab49963f20a70430fba8d4d0d6 --- /dev/null +++ b/456/InvasionFront_CD3_block13_x4_y12_patient456_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 28959.7, + "Num Detections": 18631, + "Num Negative": 17212, + "Num Positive": 1419, + "Positive %": 7.616, + "Num Positive per mm^2": 594.38 + } +} \ No newline at end of file diff --git a/456/InvasionFront_CD8_block13_x3_y12_patient456_0.json b/456/InvasionFront_CD8_block13_x3_y12_patient456_0.json new file mode 100644 index 0000000000000000000000000000000000000000..45661723b1c86fba7a4964bbcb03a25a1cf5ee0e --- /dev/null +++ b/456/InvasionFront_CD8_block13_x3_y12_patient456_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11294.0, + "Centroid Y µm": 30883.6, + "Num Detections": 20835, + "Num Negative": 19332, + "Num Positive": 1503, + "Positive %": 7.214, + "Num Positive per mm^2": 584.31 + } +} \ No newline at end of file diff --git a/456/InvasionFront_CD8_block13_x4_y12_patient456_1.json b/456/InvasionFront_CD8_block13_x4_y12_patient456_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c742a30e6daedf37ba6af09abfbf01f6ba99af0 --- /dev/null +++ b/456/InvasionFront_CD8_block13_x4_y12_patient456_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 31033.6, + "Num Detections": 20191, + "Num Negative": 18747, + "Num Positive": 1444, + "Positive %": 7.152, + "Num Positive per mm^2": 579.53 + } +} \ No newline at end of file diff --git a/456/TumorCenter_CD3_block13_x3_y12_patient456_0.json b/456/TumorCenter_CD3_block13_x3_y12_patient456_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a25a2d717cfac74da0fd35638c5c3cf7a1143e1a --- /dev/null +++ b/456/TumorCenter_CD3_block13_x3_y12_patient456_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 36380.7, + "Num Detections": 19844, + "Num Negative": 17300, + "Num Positive": 2544, + "Positive %": 12.82, + "Num Positive per mm^2": 1025.8 + } +} \ No newline at end of file diff --git a/456/TumorCenter_CD3_block13_x4_y12_patient456_1.json b/456/TumorCenter_CD3_block13_x4_y12_patient456_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0d546bd193ed70612f701262fd66de6940cee016 --- /dev/null +++ b/456/TumorCenter_CD3_block13_x4_y12_patient456_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13317.9, + "Centroid Y µm": 36530.7, + "Num Detections": 19146, + "Num Negative": 17169, + "Num Positive": 1977, + "Positive %": 10.33, + "Num Positive per mm^2": 791.11 + } +} \ No newline at end of file diff --git a/456/TumorCenter_CD8_block13_x3_y12_patient456_0.json b/456/TumorCenter_CD8_block13_x3_y12_patient456_0.json new file mode 100644 index 0000000000000000000000000000000000000000..94755eda01518cf500929722ccc795074dddab81 --- /dev/null +++ b/456/TumorCenter_CD8_block13_x3_y12_patient456_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 29509.4, + "Num Detections": 18993, + "Num Negative": 18055, + "Num Positive": 938, + "Positive %": 4.939, + "Num Positive per mm^2": 387.72 + } +} \ No newline at end of file diff --git a/456/TumorCenter_CD8_block13_x4_y12_patient456_1.json b/456/TumorCenter_CD8_block13_x4_y12_patient456_1.json new file mode 100644 index 0000000000000000000000000000000000000000..83b47a4ba7568da94f0e3cf1b80f0c4f2e67b276 --- /dev/null +++ b/456/TumorCenter_CD8_block13_x4_y12_patient456_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16116.5, + "Centroid Y µm": 29209.5, + "Num Detections": 16763, + "Num Negative": 15918, + "Num Positive": 845, + "Positive %": 5.041, + "Num Positive per mm^2": 349.02 + } +} \ No newline at end of file diff --git a/456/history_text.txt b/456/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b9c5d2ff4123b1b82c633f92416c3436181fed42 --- /dev/null +++ b/456/history_text.txt @@ -0,0 +1 @@ +The patient has had a mass on her right tongue since <2018>, with 30 py and daily wine consumption. The CT scan from <2018> also shows a high-grade cT2 tongue margin carcinoma on the right side with a solitary, ipsilateral lymph node and post-inflammatory lung changes. In addition, an adrenal incidentaloma is most likely to be seen on the left side. In the absence of pre-existing histology, there is an indication for panendoscopy and frozen section and then, if necessary, further procedures. The patient had enough time to ask questions before the operation. \ No newline at end of file diff --git a/456/icd_codes.txt b/456/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1c4770dc7b0afc88d815a04e7b404d87cfce9a9f --- /dev/null +++ b/456/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] Zungenrandkarzinom[C02.1 R] Nasenkarzinom[C76.0 L] \ No newline at end of file diff --git a/456/ops_codes.txt b/456/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..04e63b9b90248a3233a04f4621ca1578b3829163 --- /dev/null +++ b/456/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Keilresektion der Zunge[5-250.2 ] Exzision an der äußeren Nase[5-212.0 ] \ No newline at end of file diff --git a/456/patient_clinical_data.json b/456/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8b9d6bf214298526bb06fe319faede0a1c0382c6 --- /dev/null +++ b/456/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 62, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/456/patient_pathological_data.json b/456/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f0bb4d4c9fb4be01f091ece07dc46ddaf2ce068 --- /dev/null +++ b/456/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "456", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 21, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/456/surgery_description.txt b/456/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2f40e8c3e8667298da99bd045752be494b7b68f1 --- /dev/null +++ b/456/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Tumor resection of the left tongue margin diff --git a/456/surgery_report.txt b/456/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..06b7d63643f2ec1e115d30a85c3089d9750dfd74 --- /dev/null +++ b/456/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater and positioning of the patient. Introductory consultation with the anesthesia department and performance of the team time-out. Problem-free intubation with Cormack I and inconspicuous tracheoscopy. Now start slinging the tongue and PE from the mass on the right edge of the tongue. This is approx. 3 x 2 ˝ cm in size and extends from the middle third of the tongue to the posterior third of the tongue, the base of the tongue itself is free, as well as in the anterior area of the mass down to the floor of the mouth. The right Wharton's duct is congested, the tongue is still mobile, no midline crossing or infiltration of the tonsillar lobe can be seen. Now esophagogastroscopy. Here the stomach is unremarkable and non-irritable, with no evidence of bleeding or a mass. Any fluid present is aspirated and the stomach is pumped out. The oesophagus is unremarkable. Now enter with the small bore tube C and inspect the rest of the oral cavity and palpate the tonsils and base of the tongue. These are unremarkable, the vallecula is clear and the epiglottis is also unremarkable. With good adjustability, the piriform sinuses are pre-mirrored and expanded. These are inconspicuous on both sides and without irritation, the posterior and lateral pharyngeal walls and the postcricoid region are also inconspicuous, the vocal folds can be adjusted well on both sides up to the anterior commissure and are also inconspicuous here. In the case of invasive squamous cell carcinoma in the frozen section, the tongue is now snared and the resection borders are marked with the ultrasonic knife. First, both papillae are dilated with the dilator and saliva is massaged out. This is possible on both sides, and it is also possible to insert a myrtle leaf probe on both sides, assuming that the duct is intact on both sides. After insertion of the myrtle leaf probe, the tumor is successively cut around with the ultrasonic knife, with palpation and inspection of the tumor extension. The tumor is successively and further removed. Identification of the lingual nerve and protection of this. However, smaller divisions of the nerve must be resected as they run directly into the tumor. Easy removal and suture marking of the tumor. Sending for frozen section. The mass at the left nasal entrance is also biopsied and sent for frozen section. This also shows a nasal entrance carcinoma, which is why resection, suture marking and removal of marginal samples are also performed here. In the small defect of the cartilage on the left side, a small full-thickness skin graft is taken from the right neck and, after notification of the frozen section (R0), this is sutured onto the left nasal entrance as a patch. The result is very good. Now feedback from the frozen section. In the case of R1 resection, the anterior floor of the mouth is resected again. These resections or margin samples are now tumor-free (R0). For this reason, the tongue is primarily closed with Vicryl 3-0. Again, care is taken to ensure that the duct is not damaged, saliva can be expressed without any problems and the duct can still be easily probed. Insertion of a nasogastric tube and completion of the operation. Conclusion: Simultaneous cT2 tongue margin carcinoma and cT1 nasal entrance carcinoma on the left side with suspected cN1 cM0. The nasogastric tube should be left in place for at least 3 days. After receiving the final histology, the patient should be presented to the interdisciplinary tumor conference. The necessity of a unilateral or bilateral neck dissection should also be discussed here. Regular gland massage and administration of Sialagoga should also be carried out. The antibiotic treatment started intraoperatively with 3 g Unacid should be continued for 1 week. The patient received a single shot of SDHS 250 mg i.v. intraoperatively. The stitches on the nose should be removed after 7 days, the stitches on the neck after 10 days. \ No newline at end of file diff --git a/457/InvasionFront_CD3_block19_x3_y7_patient457_0.json b/457/InvasionFront_CD3_block19_x3_y7_patient457_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e1980de56554a90752cbe8dd12c9a5635aac9604 --- /dev/null +++ b/457/InvasionFront_CD3_block19_x3_y7_patient457_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11793.8, + "Centroid Y µm": 19714.6, + "Num Detections": 15801, + "Num Negative": 15405, + "Num Positive": 396, + "Positive %": 2.506, + "Num Positive per mm^2": 213.97 + } +} \ No newline at end of file diff --git a/457/InvasionFront_CD3_block19_x4_y7_patient457_1.json b/457/InvasionFront_CD3_block19_x4_y7_patient457_1.json new file mode 100644 index 0000000000000000000000000000000000000000..33d4b9f5b3f838fb6ce38232bf9f7a7465295260 --- /dev/null +++ b/457/InvasionFront_CD3_block19_x4_y7_patient457_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14292.4, + "Centroid Y µm": 19889.5, + "Num Detections": 17138, + "Num Negative": 16489, + "Num Positive": 649, + "Positive %": 3.787, + "Num Positive per mm^2": 331.13 + } +} \ No newline at end of file diff --git a/457/InvasionFront_CD8_block19_x3_y7_patient457_0.json b/457/InvasionFront_CD8_block19_x3_y7_patient457_0.json new file mode 100644 index 0000000000000000000000000000000000000000..61408709ac17d2b38d2fbc8cd1203aaac6604e51 --- /dev/null +++ b/457/InvasionFront_CD8_block19_x3_y7_patient457_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11718.8, + "Centroid Y µm": 27385.5, + "Num Detections": 17112, + "Num Negative": 16148, + "Num Positive": 964, + "Positive %": 5.633, + "Num Positive per mm^2": 433.79 + } +} \ No newline at end of file diff --git a/457/InvasionFront_CD8_block19_x4_y7_patient457_1.json b/457/InvasionFront_CD8_block19_x4_y7_patient457_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fe773fef6f76493c6aae67ebd2e0eb71e2a64718 --- /dev/null +++ b/457/InvasionFront_CD8_block19_x4_y7_patient457_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14117.5, + "Centroid Y µm": 27485.4, + "Num Detections": 16135, + "Num Negative": 14773, + "Num Positive": 1362, + "Positive %": 8.441, + "Num Positive per mm^2": 633.07 + } +} \ No newline at end of file diff --git a/457/TumorCenter_CD3_block19_x3_y7_patient457_0.json b/457/TumorCenter_CD3_block19_x3_y7_patient457_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4dff43020872d27523c117689d14520baffd5395 --- /dev/null +++ b/457/TumorCenter_CD3_block19_x3_y7_patient457_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12443.4, + "Centroid Y µm": 18765.1, + "Num Detections": 15793, + "Num Negative": 15235, + "Num Positive": 558, + "Positive %": 3.533, + "Num Positive per mm^2": 258.49 + } +} \ No newline at end of file diff --git a/457/TumorCenter_CD3_block19_x4_y7_patient457_1.json b/457/TumorCenter_CD3_block19_x4_y7_patient457_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c8e8287b3fdade7c3d59cc725a07daaa325d9e3c --- /dev/null +++ b/457/TumorCenter_CD3_block19_x4_y7_patient457_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14867.1, + "Centroid Y µm": 18365.3, + "Num Detections": 19033, + "Num Negative": 18602, + "Num Positive": 431, + "Positive %": 2.264, + "Num Positive per mm^2": 193.57 + } +} \ No newline at end of file diff --git a/457/TumorCenter_CD8_block19_x3_y7_patient457_0.json b/457/TumorCenter_CD8_block19_x3_y7_patient457_0.json new file mode 100644 index 0000000000000000000000000000000000000000..48ce1bb4a3d45dceac4a5b2953f1532b78d44268 --- /dev/null +++ b/457/TumorCenter_CD8_block19_x3_y7_patient457_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 28784.8, + "Num Detections": 14265, + "Num Negative": 13831, + "Num Positive": 434, + "Positive %": 3.042, + "Num Positive per mm^2": 215.9 + } +} \ No newline at end of file diff --git a/457/TumorCenter_CD8_block19_x4_y7_patient457_1.json b/457/TumorCenter_CD8_block19_x4_y7_patient457_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8b86e68de7b1a1bd0e4c620d5b4f34b7603385f4 --- /dev/null +++ b/457/TumorCenter_CD8_block19_x4_y7_patient457_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 28684.8, + "Num Detections": 17613, + "Num Negative": 17241, + "Num Positive": 372, + "Positive %": 2.112, + "Num Positive per mm^2": 169.23 + } +} \ No newline at end of file diff --git a/457/history_text.txt b/457/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..95a0b55adcc38c8d169cb1ce249af7a6fd8f7f1b --- /dev/null +++ b/457/history_text.txt @@ -0,0 +1 @@ +Patient with a histologically confirmed cT2 G3 squamous cell carcinoma in the area of the right supraglottis following tumor resection with neck dissection on both sides and adjuvant radiotherapy for oropharyngeal carcinoma 16 years ago. Indication for the above measures. \ No newline at end of file diff --git a/457/icd_codes.txt b/457/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7af9d48e72358f0d6d1087f5348fc77085d2054 --- /dev/null +++ b/457/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 R] \ No newline at end of file diff --git a/457/ops_codes.txt b/457/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fdee3960f8346b9ed4486b1696cb3f25a0bc975a --- /dev/null +++ b/457/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Endoskopische Laserresektion am Larynx[5-302.5 ] \ No newline at end of file diff --git a/457/patient_clinical_data.json b/457/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1c9d1657e607dddd0da1d5a895ebf6ffff5efd1f --- /dev/null +++ b/457/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 77, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/457/patient_pathological_data.json b/457/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d78fa755cf49e2e42bc487c2e6649b8aca2aa54d --- /dev/null +++ b/457/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "457", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris1", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/457/surgery_description.txt b/457/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c3b352c95896cc039a1bc806d3f9cbf048c45e1f --- /dev/null +++ b/457/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, MLE (Microlaryngoscopy and Endoscopy) diff --git a/457/surgery_report.txt b/457/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4c2e4a7a2ccf09b8b8bc3ad7f2bd5e7ba4324afb --- /dev/null +++ b/457/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia, transoral endotracheal intubation using a laser tube by the anesthesia colleagues. Positioning of the patient by the surgeon. Laryngoscopy performed using a Kleinsasser C-tube. Inconspicuous conditions there. Inspection of the supraglottis revealed an exophytic mass covered by rough mucosa, which subtotally occupied the laryngeal surface of the epiglottis and completely invaded the pharyngoepiglottic fold laterally. Clamping of the spreading laryngoscope and adjustment of the findings. Setting the CO2 laser to a power of 6 W in continuous mode and successive traversing of the findings, which were removed using the piecemeal technique. Subsequently, three marginal samples were taken (central tongue base, right lateral pharyngeal side wall, right posterior pharyngeal side wall). In the third marginal sample ( pharyngeal lateral wall right posterior ), focal CIS parts were detected by the pathology colleagues. Thus, generous resection in this region and removal of a second marginal sample at the same site. Both the resected specimen and the second marginal specimen were sent for final histology. Hemostasis there by means of bipolar coagulation. An arterial vessel was treated three times with a clip. Repeated inspection. Dry conditions. Completion of the procedure without complications. The patient was to be fed exclusively via PEG for the next 7 days. \ No newline at end of file diff --git a/458/InvasionFront_CD3_block3_x5_y4_patient458_0.json b/458/InvasionFront_CD3_block3_x5_y4_patient458_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14bf08f8d93aa2536e79a15acd42451299301bb6 --- /dev/null +++ b/458/InvasionFront_CD3_block3_x5_y4_patient458_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 15416.8, + "Num Detections": 20999, + "Num Negative": 19117, + "Num Positive": 1882, + "Positive %": 8.962, + "Num Positive per mm^2": 745.34 + } +} \ No newline at end of file diff --git a/458/InvasionFront_CD3_block3_x6_y4_patient458_1.json b/458/InvasionFront_CD3_block3_x6_y4_patient458_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f022634f9b32b240edbeb23501e62ca9d1742f53 --- /dev/null +++ b/458/InvasionFront_CD3_block3_x6_y4_patient458_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21513.6, + "Centroid Y µm": 15416.8, + "Num Detections": 21931, + "Num Negative": 20656, + "Num Positive": 1275, + "Positive %": 5.814, + "Num Positive per mm^2": 505.54 + } +} \ No newline at end of file diff --git a/458/InvasionFront_CD8_block3_x5_y4_patient458_0.json b/458/InvasionFront_CD8_block3_x5_y4_patient458_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fb995270f43438ca38698d946ff06cf26629a4ed --- /dev/null +++ b/458/InvasionFront_CD8_block3_x5_y4_patient458_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17562.9, + "Centroid Y µm": 9715.5, + "Num Detections": 22021, + "Num Negative": 20050, + "Num Positive": 1971, + "Positive %": 8.951, + "Num Positive per mm^2": 787.8 + } +} \ No newline at end of file diff --git a/458/InvasionFront_CD8_block3_x6_y4_patient458_1.json b/458/InvasionFront_CD8_block3_x6_y4_patient458_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1e451c5934e057296ff2baf5fc68a274d3e6a350 --- /dev/null +++ b/458/InvasionFront_CD8_block3_x6_y4_patient458_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20228.0, + "Centroid Y µm": 9643.3, + "Num Detections": 19010, + "Num Negative": 18450, + "Num Positive": 560, + "Positive %": 2.946, + "Num Positive per mm^2": 222.99 + } +} \ No newline at end of file diff --git a/458/TumorCenter_CD3_block3_x5_y4_patient458_0.json b/458/TumorCenter_CD3_block3_x5_y4_patient458_0.json new file mode 100644 index 0000000000000000000000000000000000000000..50c47282173ebc7f41a7c0f9752488801058d603 --- /dev/null +++ b/458/TumorCenter_CD3_block3_x5_y4_patient458_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16211.5, + "Centroid Y µm": 16249.4, + "Num Detections": 13411, + "Num Negative": 11455, + "Num Positive": 1956, + "Positive %": 14.59, + "Num Positive per mm^2": 1174.5 + } +} \ No newline at end of file diff --git a/458/TumorCenter_CD3_block3_x6_y4_patient458_1.json b/458/TumorCenter_CD3_block3_x6_y4_patient458_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f35fed3fd8af527c623e36e37fd3cd542db0cd5b --- /dev/null +++ b/458/TumorCenter_CD3_block3_x6_y4_patient458_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18629.7, + "Centroid Y µm": 16205.7, + "Num Detections": 358, + "Num Negative": 325, + "Num Positive": 33, + "Positive %": 9.218, + "Num Positive per mm^2": 394.76 + } +} \ No newline at end of file diff --git a/458/TumorCenter_CD8_block3_x5_y4_patient458_0.json b/458/TumorCenter_CD8_block3_x5_y4_patient458_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4fc904d16e3dfe04bdf33637dc87408dbbcdb8d9 --- /dev/null +++ b/458/TumorCenter_CD8_block3_x5_y4_patient458_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17190.9, + "Centroid Y µm": 11693.8, + "Num Detections": 22458, + "Num Negative": 21132, + "Num Positive": 1326, + "Positive %": 5.904, + "Num Positive per mm^2": 547.92 + } +} \ No newline at end of file diff --git a/458/TumorCenter_CD8_block3_x6_y4_patient458_1.json b/458/TumorCenter_CD8_block3_x6_y4_patient458_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7987388f6fe27c7740dc661ca35bde40fe143b98 --- /dev/null +++ b/458/TumorCenter_CD8_block3_x6_y4_patient458_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19714.6, + "Centroid Y µm": 11818.7, + "Num Detections": 14499, + "Num Negative": 13850, + "Num Positive": 649, + "Positive %": 4.476, + "Num Positive per mm^2": 365.65 + } +} \ No newline at end of file diff --git a/458/history_text.txt b/458/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/458/icd_codes.txt b/458/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/458/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/458/ops_codes.txt b/458/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c20d9dc4dc87e20034851083d63b25469b8c663d --- /dev/null +++ b/458/ops_codes.txt @@ -0,0 +1 @@ +Pharyngotomie lateral[5-290.3 ] Transplantat[5-295.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Temporäre Tracheotomie[5-311.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Biopsie ohne Inzision Larynx sonstige Lokalisation[1-421.x ] Entnahme myokutaner Lappen mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.28 R] \ No newline at end of file diff --git a/458/patient_clinical_data.json b/458/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2ac513b6c31d26d945ddb3df07872555336cef78 --- /dev/null +++ b/458/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 45, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/458/patient_pathological_data.json b/458/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9a6af4f9ef287983ef28aa1675776218c8c2e8a2 --- /dev/null +++ b/458/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "458", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 54, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/458/surgery_description.txt b/458/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc8915f937765a85a64bff0bee84938e7b5f46e5 --- /dev/null +++ b/458/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Pedicled flap (ALT) diff --git a/458/surgery_report.txt b/458/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..71187e4e3ae07ba7c49a967f66549ecd8be18051 --- /dev/null +++ b/458/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and positioning of the patient. Entry with the small bore tube and inspection of the tumor. A flat, exophytic mass is seen on the right side, which starts on the pharyngeal side wall approx. 1 cm below the tonsil lobe on the right side and grows caudally. The mass ends at the entrance of the piriform sinus. The tip of the piriform sinus is free. The tumor infiltrates the mucosa at the arytenoid cartilage. However, the arytenoid cartilage itself is still mobile and does not appear to be deeply infiltrated. Infiltration of the thyroid cartilage cannot be ruled out. Intraoperative demonstration of the findings on and . It is decided to open the pharynx from the outside and perform the tumor resection from the cervical right side. First perform the neck dissection on the right side. To do this, expose the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the cervical vascular sheath. Free preparation of the internal jugular vein and clearing of neck levels II a to V a while sparing the plexus branches and the accessorius and hypoglossal nerves. Now dissect the thyroid gland from the hypopharyngeal and laryngeal area and enter the pharynx through . The tumor can be easily visualized and is successively incised. The tumor itself can be retrieved en bloc. It is clear from the tumor resection that there is limited thyroid cartilage infiltration. In this case, thyroid cartilage is also resected and sent to histology attached to the tumor specimen. Now take edge samples. All mucosal margins are removed, including in the area of the arytenoid cartilage and soft tissue. All marginal samples are classified as R0 in the frozen section. The defect is so large that it cannot be closed primarily. A platysma flap was originally planned to cover the defect; this was also prepared in the caudal region and on the posterior surface as part of the skin incision. Ultimately, it became apparent that the patient's upper skin was extremely thin and there was virtually no subcutaneous layer, which meant that the platysma flap was not possible to cover the defect, as it could not be guaranteed that the remaining skin would remain vital. It was therefore decided to cover the defect with an anterolateral thigh graft. Turning to the leg. First Doppler the perforator vessels. 1 main perforator and 2 secondary perforators can be detected. The graft is drawn in so that the main perforator is positioned exactly in the center of the graft. Now incise along the anterior edge down to the rectus femoris muscle. Then dissect laterally into the sulcus between the rectus femoris and vastus lateralis muscles. The descending ramus can be localized here and followed cranially to the profunda femoris artery. From the descending ramus, the main perforator is localized using the Doppler and carefully dissected towards the graft so that it is completely preserved. The graft can now be cut around completely and the pedicle vessel can be placed at the bottom. A very good graft perforation can be seen over the main perforator the whole time. The 2 secondary perforators do not extend directly into the skin, but rather deep into the muscle, which is why they cannot be integrated into the graft. At the end, dissection of the pedicle and removal of the pedicle far proximally. Primary wound closure in several layers in the area of the remaining leg wound. The graft is sutured into place. Suturing must be carried out using pre-positioned sutures and is somewhat difficult, especially in the area of the base of the tongue. Finally, the anastomosis is performed. The arterial vessel is sutured to the superior thyroid artery, which must be very well prepared for this, as it is much smaller in caliber than the flap vessel. Nevertheless, an anastomosis can be created. The vein is connected to an outlet from the internal jugular vein using a coupler. Then graft control. There is good blood flow. Insertion of a Redon drain on the left side and a flap on the right side. Even before the neck is completely sutured shut, venous congestion is seen in the flap vessel, so the inserted coupler has to be opened again and it becomes apparent that the coupler was directly in front of a venous valve. The vein in the flap pedicle is therefore prepared and shortened again and recoupled to another vein. Now permanent, good return flow, therefore two-layer wound closure on the neck and insertion of a tracheal cannula after a tracheotomy was performed in the usual manner. Please check the flap according to the usual procedure. Continue antibiotics for at least 24 hours. Feeding via the PEG tube. The inserted nasogastric tube should be left in place as a splint for 10 days. If there is any indication of a fistula, please open the neck. \ No newline at end of file diff --git a/459/InvasionFront_CD3_block11_x5_y6_patient459_0.json b/459/InvasionFront_CD3_block11_x5_y6_patient459_0.json new file mode 100644 index 0000000000000000000000000000000000000000..12bdc1d621e886b41a61e486c2a6e1a51d1de924 --- /dev/null +++ b/459/InvasionFront_CD3_block11_x5_y6_patient459_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15591.7, + "Centroid Y µm": 14542.3, + "Num Detections": 10273, + "Num Negative": 9004, + "Num Positive": 1269, + "Positive %": 12.35, + "Num Positive per mm^2": 1105.7 + } +} \ No newline at end of file diff --git a/459/InvasionFront_CD3_block11_x6_y6_patient459_1.json b/459/InvasionFront_CD3_block11_x6_y6_patient459_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8729ddfc7ec8acc770a89c5a652733e14b7fde69 --- /dev/null +++ b/459/InvasionFront_CD3_block11_x6_y6_patient459_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18065.4, + "Centroid Y µm": 14317.4, + "Num Detections": 19597, + "Num Negative": 18108, + "Num Positive": 1489, + "Positive %": 7.598, + "Num Positive per mm^2": 692.64 + } +} \ No newline at end of file diff --git a/459/InvasionFront_CD8_block11_x5_y6_patient459_0.json b/459/InvasionFront_CD8_block11_x5_y6_patient459_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6b886ba8edeff08c1e8478018da0b76a70355b67 --- /dev/null +++ b/459/InvasionFront_CD8_block11_x5_y6_patient459_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18379.8, + "Centroid Y µm": 25503.5, + "Num Detections": 2958, + "Num Negative": 2835, + "Num Positive": 123, + "Positive %": 4.158, + "Num Positive per mm^2": 368.45 + } +} \ No newline at end of file diff --git a/459/InvasionFront_CD8_block11_x6_y6_patient459_1.json b/459/InvasionFront_CD8_block11_x6_y6_patient459_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f8ddb4a69def8eb6a30cd64da63e67c7f2a4d741 --- /dev/null +++ b/459/InvasionFront_CD8_block11_x6_y6_patient459_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20949.9, + "Centroid Y µm": 25618.4, + "Num Detections": 7266, + "Num Negative": 7177, + "Num Positive": 89, + "Positive %": 1.225, + "Num Positive per mm^2": 106.07 + } +} \ No newline at end of file diff --git a/459/TumorCenter_CD3_block11_x5_y6_patient459_0.json b/459/TumorCenter_CD3_block11_x5_y6_patient459_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4191c323581409608821c6128cba11fb5539dc92 --- /dev/null +++ b/459/TumorCenter_CD3_block11_x5_y6_patient459_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19161.8, + "Centroid Y µm": 15004.9, + "Num Detections": 19099, + "Num Negative": 18041, + "Num Positive": 1058, + "Positive %": 5.54, + "Num Positive per mm^2": 472.78 + } +} \ No newline at end of file diff --git a/459/TumorCenter_CD3_block11_x6_y6_patient459_1.json b/459/TumorCenter_CD3_block11_x6_y6_patient459_1.json new file mode 100644 index 0000000000000000000000000000000000000000..56d934392aecc75aaaebb609f81d825d90292680 --- /dev/null +++ b/459/TumorCenter_CD3_block11_x6_y6_patient459_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21628.5, + "Centroid Y µm": 15173.0, + "Num Detections": 18827, + "Num Negative": 17840, + "Num Positive": 987, + "Positive %": 5.242, + "Num Positive per mm^2": 416.55 + } +} \ No newline at end of file diff --git a/459/TumorCenter_CD8_block11_x5_y6_patient459_0.json b/459/TumorCenter_CD8_block11_x5_y6_patient459_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6e932037db5c89511eb3531a4d9b1761d534397d --- /dev/null +++ b/459/TumorCenter_CD8_block11_x5_y6_patient459_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 14842.1, + "Num Detections": 19315, + "Num Negative": 19199, + "Num Positive": 116, + "Positive %": 0.6006, + "Num Positive per mm^2": 51.94 + } +} \ No newline at end of file diff --git a/459/TumorCenter_CD8_block11_x6_y6_patient459_1.json b/459/TumorCenter_CD8_block11_x6_y6_patient459_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ca03a5bd2d121fecf3d82b69821255d410a8eb62 --- /dev/null +++ b/459/TumorCenter_CD8_block11_x6_y6_patient459_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 14942.1, + "Num Detections": 18703, + "Num Negative": 18606, + "Num Positive": 97, + "Positive %": 0.5186, + "Num Positive per mm^2": 41.47 + } +} \ No newline at end of file diff --git a/459/history_text.txt b/459/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8fd1ca9605402f04feb97a0ad6da0d94a42a7d41 --- /dev/null +++ b/459/history_text.txt @@ -0,0 +1 @@ +History of progressive left cervical lymph node since <2011>. External bioptic histological confirmation of a moderately differentiated keratinized squamous cell carcinoma. Acceptance of the externally performed computed tomography, it showed a restless mucosa in the area of the left palatal arch up to the entrance into the left piriform sinus. However, there was no evidence of a primary tumor in the area of the left tonsillar lobe on endoscopy. In summary of the findings, a left cervical CUP syndrome is now suspected. There is now an indication for panendoscopy, including biopsy and PEG placement if necessary. If the intraoperative findings were unremarkable, a CUP panendoscopy was also discussed in consultation with the patient. The patient had ample opportunity to ask questions about the procedure explained. \ No newline at end of file diff --git a/459/icd_codes.txt b/459/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7158cad75f1f8425ff3563366c5a563d21cd049 --- /dev/null +++ b/459/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Gaumenbogentonsillen[C09.1 ] \ No newline at end of file diff --git a/459/ops_codes.txt b/459/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ddbce73aa341e951a820ae2a2dcc4206b36f1c50 --- /dev/null +++ b/459/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] Diagnostische Laryngoskopie direkt[1-610.0 ] Tonsillenbiopsie[1-422.01 R] Transorale Tumortonsillektomie[5-281.2 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] \ No newline at end of file diff --git a/459/patient_clinical_data.json b/459/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..921ec2fc77b392b19c445e16215d862e2a2e801f --- /dev/null +++ b/459/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/459/patient_pathological_data.json b/459/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..151f5a761a4ab89ff29cc384ffbc0a1654206aff --- /dev/null +++ b/459/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "459", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/459/surgery_description.txt b/459/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9cbb5dd7512b53881ed12f0b3b30011a4878af5e --- /dev/null +++ b/459/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, PEG placement, Panendoscopy, PE (Proximal esophagus) diff --git a/459/surgery_report.txt b/459/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4802a5f827e97e67e7ecac74017f6f9d62ecf627 --- /dev/null +++ b/459/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, rigid tracheoscopy is performed using the 0 degree optic. Passing the glottis and entering endotracheally. The mucosal conditions are unremarkable on all sides up to the tracheal bifurcation. Subsequently problem-free intubation by the surgeon. Then insertion of the mouth guard and insertion with the Kleinsasser C-tube. Adjustment of the endolarynx. The mucosal conditions are inconspicuous on all sides. Then enter the piriform sinus on the right and left. This can be freely unfolded on both sides and is lined with smooth mucosa on all sides up to the tip of the piriform sinus. In the area of the postcricoid and the esophageal entrance, the mucosa is also normal on all sides. Subsequent inspection of the vallecular region and the base of the tongue. Here, too, there is no evidence of a primary tumor. Then proceed to inspection of the rest of the oropharynx. Start on the left side. Primary inspection also reveals a non-irritant, inconspicuous tonsil lobe. However, during the meticulous inspection in the case of an externally expressed suspicion of a left-sided tonsillar carcinoma, a superficially growing exophytic growth appears deep in a crypt. This is limited to the central area of the left tonsil. The anterior and posterior palatal arch appears macroscopically tumor-free. Subsequent inspection of the right tonsillar lobe. A superficial leukoplakic mucosal change was found, which was biopsied and sent for definitive histology. Otherwise, there was no evidence of a tumor in the rest of the oropharynx or oral cavity either by inspection or palpation. Subsequent demonstration of the findings and planning of the further procedure with and . The decision is made to perform a tumor tonsillectomy due to the circumscribed tumor growth. Insertion of the Mc Ivor oral spatula. Parauvular incision of the mucosa and performance of a tomortonsillectomy under strict control of the marcroscopic tumor borders. Partial resection of the anterior and posterior palatal arch and extension of the resection towards the base of the tongue. The tumor resection is made in toto for frozen section dignostics. Suture marking is performed cranially and in the area of the anterior palatal arch. After meticulous inspection of the tumor resectate, the decision is made to send a flat resectate in the area of the anterior palatal arch for frozen section diagnostics. This is followed by meticulous. Hemostasis using bipolar coagulation. Transition to placement of the PEG tube. Insertion of the endoscope under visualization and constant air insufflation into the stomach. Only slight reflux-associated mucosal changes are seen in the distal esophagus. However, there is no evidence of a secondary malignancy. Subsequent entry into the stomach. Here, too, a regular, non-irritant gastric mucosal relief is seen. The diaphanoscopy is then performed and the PEG tube is inserted in the typical manner using the suture pull method. During the telephone frozen section announcement, invasive tonsillar carcinoma with marginal filling in the area of the central wound bed. Furthermore, suspected cis-spurs in the area of the cranial resection margin in the area of the upper tonsil pole and the caudal resection margin towards the base of the tongue. ....... Cis spurs are also visible at the resection margin of the anterior palatal arch. However, the resected resectate is completely tumor-free. Thus, generous resection cranially in the area of the upper tonsil pole transition anterior palatal arch, in the area of the central wound bed laterally and caudally towards the base of the tongue. The resection is performed by . Resection is performed laterally up to the neck fat. Subsequent meticulous hemostasis using bipolar coagulation. Due to the more extensive tumor tonsillectomy, further waiting of just under 10 minutes and completion of the operation with a dry wound bed. Conclusion: Due to the unexpectedly large extent of the tumor in the frozen section diagnosis, this is a cT2cN2c tonsillar carcinoma on the left. The tumor resection is clinically macroscopically clearly sano. With regard to the pending neck dissection, wait at least two weeks, as otherwise there is a risk of a penetrating defect afterwards enorally. As the patient was not ......tomized, the patient is transferred to the local intensive care unit awake and breathing spontaneously for monitoring. \ No newline at end of file diff --git a/460/InvasionFront_CD3_block2_x5_y7_patient460_0.json b/460/InvasionFront_CD3_block2_x5_y7_patient460_0.json new file mode 100644 index 0000000000000000000000000000000000000000..356ecc006a290e7f9b2b8d82bb9269531d0fac28 --- /dev/null +++ b/460/InvasionFront_CD3_block2_x5_y7_patient460_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18640.1, + "Centroid Y µm": 31158.5, + "Num Detections": 19440, + "Num Negative": 17672, + "Num Positive": 1768, + "Positive %": 9.095, + "Num Positive per mm^2": 811.15 + } +} \ No newline at end of file diff --git a/460/InvasionFront_CD3_block2_x6_y7_patient460_1.json b/460/InvasionFront_CD3_block2_x6_y7_patient460_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a7570f6ab8a1a27a20582d4cfa084d08da38ea2 --- /dev/null +++ b/460/InvasionFront_CD3_block2_x6_y7_patient460_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21213.8, + "Centroid Y µm": 31233.5, + "Num Detections": 23193, + "Num Negative": 20597, + "Num Positive": 2596, + "Positive %": 11.19, + "Num Positive per mm^2": 1015.1 + } +} \ No newline at end of file diff --git a/460/InvasionFront_CD8_block2_x5_y7_patient460_0.json b/460/InvasionFront_CD8_block2_x5_y7_patient460_0.json new file mode 100644 index 0000000000000000000000000000000000000000..48e8c502f12e25537831fbe56ebaebedcfffdc0e --- /dev/null +++ b/460/InvasionFront_CD8_block2_x5_y7_patient460_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17415.8, + "Centroid Y µm": 18890.0, + "Num Detections": 9818, + "Num Negative": 8724, + "Num Positive": 1094, + "Positive %": 11.14, + "Num Positive per mm^2": 868.23 + } +} \ No newline at end of file diff --git a/460/InvasionFront_CD8_block2_x6_y7_patient460_1.json b/460/InvasionFront_CD8_block2_x6_y7_patient460_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7d4f727765c746fd2de48cba5c59e6229ebd4409 --- /dev/null +++ b/460/InvasionFront_CD8_block2_x6_y7_patient460_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 19064.9, + "Num Detections": 21638, + "Num Negative": 18707, + "Num Positive": 2931, + "Positive %": 13.55, + "Num Positive per mm^2": 1219.7 + } +} \ No newline at end of file diff --git a/460/TumorCenter_CD3_block2_x5_y7_patient460_0.json b/460/TumorCenter_CD3_block2_x5_y7_patient460_0.json new file mode 100644 index 0000000000000000000000000000000000000000..61cd00d034a3293fcbaa10d68d858fdb0d92d846 --- /dev/null +++ b/460/TumorCenter_CD3_block2_x5_y7_patient460_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 17465.8, + "Num Detections": 15280, + "Num Negative": 15009, + "Num Positive": 271, + "Positive %": 1.774, + "Num Positive per mm^2": 119.64 + } +} \ No newline at end of file diff --git a/460/TumorCenter_CD3_block2_x6_y7_patient460_1.json b/460/TumorCenter_CD3_block2_x6_y7_patient460_1.json new file mode 100644 index 0000000000000000000000000000000000000000..10637629b24da790417be75b812ad63d2f3c55ea --- /dev/null +++ b/460/TumorCenter_CD3_block2_x6_y7_patient460_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 17590.7, + "Num Detections": 16897, + "Num Negative": 16391, + "Num Positive": 506, + "Positive %": 2.995, + "Num Positive per mm^2": 232.18 + } +} \ No newline at end of file diff --git a/460/TumorCenter_CD8_block2_x5_y7_patient460_0.json b/460/TumorCenter_CD8_block2_x5_y7_patient460_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dbec55cfd6b1cda21ca112642033ab613ea0b65c --- /dev/null +++ b/460/TumorCenter_CD8_block2_x5_y7_patient460_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 17190.9, + "Num Detections": 15934, + "Num Negative": 15830, + "Num Positive": 104, + "Positive %": 0.6527, + "Num Positive per mm^2": 46.06 + } +} \ No newline at end of file diff --git a/460/TumorCenter_CD8_block2_x6_y7_patient460_1.json b/460/TumorCenter_CD8_block2_x6_y7_patient460_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e80a3b29444ac875720501c9ad05d73c8b4054f0 --- /dev/null +++ b/460/TumorCenter_CD8_block2_x6_y7_patient460_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20614.1, + "Centroid Y µm": 17190.9, + "Num Detections": 16355, + "Num Negative": 16107, + "Num Positive": 248, + "Positive %": 1.516, + "Num Positive per mm^2": 113.16 + } +} \ No newline at end of file diff --git a/460/history_text.txt b/460/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..72d7d91711d1b4e5ad5062e5fa94c01e17451c92 --- /dev/null +++ b/460/history_text.txt @@ -0,0 +1 @@ +The patient underwent a panendoscopy and a cT2 to 3 supraglottic laryngeal carcinoma was histologically confirmed on the right side, particularly in the epiglottis area. Due to the multimorbid patient, surgical treatment was favored. Initially planned transoral resection with good adjustability and rather exophytic tumor growth. Due to the unclear swallowing prognosis, neck dissection on both sides was initially dispensed with, possibly in combination with residual laryngectomy for functional reasons. \ No newline at end of file diff --git a/460/icd_codes.txt b/460/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/460/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/460/ops_codes.txt b/460/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..57eed4448a29f5e8ff5cff3743454584cb07ba7d --- /dev/null +++ b/460/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Epiglottektomie durch Stützlaryngoskopie[5-302.0 ] Sonstige partielle Laryngektomie[5-302.x ] Anwendung Operation-Roboter - Zusatzcode[5-987 ] \ No newline at end of file diff --git a/460/patient_clinical_data.json b/460/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dd49ef84a5bf51fb008e6babf5cfc859ecd8ea2b --- /dev/null +++ b/460/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 75, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 30, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/460/patient_pathological_data.json b/460/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a80c3bdeaa2bf886772fb083cc20cc288efdd37b --- /dev/null +++ b/460/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "460", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 27.0 +} \ No newline at end of file diff --git a/460/surgery_description.txt b/460/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d7a7f91acec2a39457b17fe6edef406021ed527b --- /dev/null +++ b/460/surgery_description.txt @@ -0,0 +1 @@ +Laryngeal partial resection, Tracheotomy, TORS (Transoral Robotic Surgery) diff --git a/460/surgery_report.txt b/460/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..649c30bb03fcbe22a51509dba9e08405f6ed2710 --- /dev/null +++ b/460/surgery_report.txt @@ -0,0 +1 @@ +After intubation and preparation by the anesthesia colleagues, a pharyngo-laryngoscopy is first performed to determine the expansion again. Entry with the Kleinsasser tube. Inspection of the inconspicuous oral cavity. An exophytic tumor process with the tumor mass primarily in the area of the vallecula and the lingual epiglottis, infiltrating it subtotally on the right side and centrally, starting at the right base of the tongue and the vallecula. Narrow margin of infiltrated tongue base on the right side, but here without deep infiltration. Tumor growth along the pharyngo-epiglottic fold in the direction of the pharyngeal side wall here circumscribed and in the direction of the aryepiglottic fold, in front of the ary excluding ary infiltration, no infiltration in the direction of the petiolus either. Now insertion of the Tors retractor and with good adjustability and good exposure of the tumor under control with the 30° optics resection and dissection of the tumor, taking a narrow margin of the base of the tongue with it. Resection in depth up to the pre-epiglottic fat. Complete removal of the epiglottis up to just before the petiolus. Superficial resection towards the side wall of the pharynx in the case of only circumscribed tumor extensions. Resection up to the arytenoid, circumscribed resection of the medial wall of the piriform sinus. Good control during preparation in depth and with macroscopic in sano resection now imaging of the tumor in the area of the mucosal margins as well as basally in the area of the epiglottis. These are free of tumor and dysplasia. Subsequently, careful wound inspection and, if the wound is dry, a tracheostomy is performed due to the extensive wound area and the expected postoperative dysphagia. To do this, make a horizontal skin incision at the level of the cricoid cartilage. Cut through the skin and subcutaneous tissue. Exposure and transection of the asymmetrically running anterior jugular vein, exposure and entry into the linea alba, lateral preparation of the infrahyoid musculature. Exposure of the cricoid cartilage, exposure of the anterior surface of the trachea. Dissection of the slender thyroid isthmus. Overall relatively low standing conditions with low standing larynx, therefore insertion between the 1st and 2nd tracheal ring. Creation of a wide tracheotomy after opening the trachea. Subsequent successive incision of the skin and subsequent problem-free reintubation to a size 9 low cuff cannula. Subsequent completion of the procedure without any indication of complications. Conclusion: Intraoperatively R0 resected, extensive cT2 G3 supraglottic laryngeal carcinoma on the right. Due to the extensive resection of the supraglottic structures, a significantly reduced swallowing prognosis is to be expected here. Prompt presentation to our colleagues in phoniatrics and subsequent joint treatment planning with regard to a functional laryngectomy if necessary. Initially, please feed via the existing PEG tube. \ No newline at end of file diff --git a/461/InvasionFront_CD3_block8_x1_y10_patient461_0.json b/461/InvasionFront_CD3_block8_x1_y10_patient461_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f1370be30435ffe14ba1ee19dbd8abf69f05bcb1 --- /dev/null +++ b/461/InvasionFront_CD3_block8_x1_y10_patient461_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 35656.1, + "Num Detections": 20780, + "Num Negative": 16515, + "Num Positive": 4265, + "Positive %": 20.52, + "Num Positive per mm^2": 1794.7 + } +} \ No newline at end of file diff --git a/461/InvasionFront_CD3_block8_x2_y10_patient461_1.json b/461/InvasionFront_CD3_block8_x2_y10_patient461_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6476f0b6ec7046b4c906fa21d1a5375396063edc --- /dev/null +++ b/461/InvasionFront_CD3_block8_x2_y10_patient461_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 35656.1, + "Num Detections": 19468, + "Num Negative": 17456, + "Num Positive": 2012, + "Positive %": 10.33, + "Num Positive per mm^2": 898.5 + } +} \ No newline at end of file diff --git a/461/InvasionFront_CD8_block8_x1_y10_patient461_0.json b/461/InvasionFront_CD8_block8_x1_y10_patient461_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d9a6484b2beb03f593112b0a2831ef567b90a475 --- /dev/null +++ b/461/InvasionFront_CD8_block8_x1_y10_patient461_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3473.2, + "Centroid Y µm": 25086.7, + "Num Detections": 21487, + "Num Negative": 19544, + "Num Positive": 1943, + "Positive %": 9.043, + "Num Positive per mm^2": 815.86 + } +} \ No newline at end of file diff --git a/461/InvasionFront_CD8_block8_x2_y10_patient461_1.json b/461/InvasionFront_CD8_block8_x2_y10_patient461_1.json new file mode 100644 index 0000000000000000000000000000000000000000..140e3bb269f087085edb86f1d919586dc7979b9a --- /dev/null +++ b/461/InvasionFront_CD8_block8_x2_y10_patient461_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 25261.6, + "Num Detections": 18494, + "Num Negative": 17258, + "Num Positive": 1236, + "Positive %": 6.683, + "Num Positive per mm^2": 582.28 + } +} \ No newline at end of file diff --git a/461/TumorCenter_CD3_block8_x1_y10_patient461_0.json b/461/TumorCenter_CD3_block8_x1_y10_patient461_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b74bb5e213da5025a615191a1d5bb0ae34c5ffaa --- /dev/null +++ b/461/TumorCenter_CD3_block8_x1_y10_patient461_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5697.0, + "Centroid Y µm": 26760.8, + "Num Detections": 20211, + "Num Negative": 15154, + "Num Positive": 5057, + "Positive %": 25.02, + "Num Positive per mm^2": 2198.0 + } +} \ No newline at end of file diff --git a/461/TumorCenter_CD3_block8_x2_y10_patient461_1.json b/461/TumorCenter_CD3_block8_x2_y10_patient461_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d0aee3cfaf43443220c7fb158f830f092f3e133 --- /dev/null +++ b/461/TumorCenter_CD3_block8_x2_y10_patient461_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8295.6, + "Centroid Y µm": 26535.9, + "Num Detections": 22100, + "Num Negative": 20333, + "Num Positive": 1767, + "Positive %": 7.995, + "Num Positive per mm^2": 757.69 + } +} \ No newline at end of file diff --git a/461/TumorCenter_CD8_block8_x1_y10_patient461_0.json b/461/TumorCenter_CD8_block8_x1_y10_patient461_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2a03a0618cb00b61267e456524d7117f4e94159e --- /dev/null +++ b/461/TumorCenter_CD8_block8_x1_y10_patient461_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4922.4, + "Centroid Y µm": 25811.3, + "Num Detections": 21430, + "Num Negative": 19701, + "Num Positive": 1729, + "Positive %": 8.068, + "Num Positive per mm^2": 742.91 + } +} \ No newline at end of file diff --git a/461/TumorCenter_CD8_block8_x2_y10_patient461_1.json b/461/TumorCenter_CD8_block8_x2_y10_patient461_1.json new file mode 100644 index 0000000000000000000000000000000000000000..833cc182946e71c449d157ab04cb31fb8626d65a --- /dev/null +++ b/461/TumorCenter_CD8_block8_x2_y10_patient461_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7546.0, + "Centroid Y µm": 25711.4, + "Num Detections": 24501, + "Num Negative": 24048, + "Num Positive": 453, + "Positive %": 1.849, + "Num Positive per mm^2": 195.96 + } +} \ No newline at end of file diff --git a/461/history_text.txt b/461/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1204132248859d977c006c29711a897770f7bfd8 --- /dev/null +++ b/461/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the right. Carcinoma is located in the piriform sinus anterior wall area, extending to the lateral wall and to the lateral part of the aryepiglottic fold. The arytenoid cartilage itself is macroscopically free, vocal fold mobility is not impaired. Corresponding extension on CT. No thyroid cartilage infiltration or infiltration of the rest of the laryngeal skeleton. \ No newline at end of file diff --git a/461/icd_codes.txt b/461/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b2621475127f7bd45f0af91d80fbe26daabf9bef --- /dev/null +++ b/461/icd_codes.txt @@ -0,0 +1 @@ +Neubildung bösartig Hypopharynx sonstige[C13.8 R] \ No newline at end of file diff --git a/461/ops_codes.txt b/461/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf1d7e6ec108d6c38745bf210d8608d722a60bd5 --- /dev/null +++ b/461/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] \ No newline at end of file diff --git a/461/patient_clinical_data.json b/461/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..25a6deff15b1389c10876399c3fb61478ff5489c --- /dev/null +++ b/461/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/461/patient_pathological_data.json b/461/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..71fd27d1450c206189f884dbfa0ee4b673897359 --- /dev/null +++ b/461/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "461", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/461/surgery_description.txt b/461/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b796265a59a8d005b745e23a700907f7f028cba --- /dev/null +++ b/461/surgery_description.txt @@ -0,0 +1 @@ +Partial larynx-pharynx resection, Pharyngoscopy, Laryngoscopy diff --git a/461/surgery_report.txt b/461/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f8fe8c50ab12cb64d2ff5441185ec3a368b763c1 --- /dev/null +++ b/461/surgery_report.txt @@ -0,0 +1 @@ +First laryngoscopy and pharyngoscopy: The exophytic process is seen at the location described. Indication for surgery given. Lateral infiltration into the wall too deep for laser resection. Position the patient, disinfect the skin, inject a total of 10 ml Ultracaine 1% with adrenaline in the area of the apron flap on both sides and cover all surgical areas with sterile drapes. First creation of an apron flap subplatysmal and dissection up to the submandibular gland and hyoid bone. Then neck dissection on the right: Dissection of the fat lymph node package from the sternocleidomastoid muscle. Exposure of the omohyoid muscle and digastric muscle. Exposure of the internal and external carotid artery as well as the internal jugular vein, facial vein and external jugular vein. Exposure and preservation of the superior thyroid artery, the superior laryngeal nerve, the vagus nerve, the accessorius nerve and the hypoglossal nerve. Then develop the neck preparation, initially dorsally, exposing and preserving the branches of the cervical plexus. Then develop the anterior neck preparation. This results in evacuation of levels II to V. Neck dissection on the left side: This is performed in the same way as on the right side. All structures are exposed and preserved. This results in evacuation of levels II to IV. Then tracheotomy: splitting of the infrahyoid musculature. Exposure of the thyroid isthmus, which is passed underneath, clamped, severed and supplied with puncture ligatures. A tracheotomy is created between the 2nd and 3rd cartilage using a wide pedicled Björk flap. This is epithelialized caudally. Subsequently reintubation and insertion of an 8 mm tracheal cannula. Tumor resection via lateral pharyngotomy on the right: exposure and isolation of the hyoid bone and superior cornu of the laryngeal skeleton. Entry into the pharynx at the level of the hyoid bone. Exposure of the tumor. Incision of the tumor with a safety margin of at least 1.5 to 2 cm on all sides of the macroscopically visible tumor. Removal of the hypopharyngeal side wall/front wall. Lateral thyroid cartilage is also removed as it is located in front of the deepest tumor infiltration. The edge of the epiglottis with vallecula and aryepiglottic fold on the right is also removed up to the arytenoid cartilage, from which the mucosa is removed, but which ultimately does not need to be removed itself. Resection includes posterior lateral areas of the postcricoid region. On the specimen, the tumor is clearly removed macroscopically in healthy tissue. The specimen is thread-marked and sent for frozen section. Carcinoma in situ infiltrates are still visible in the lateral epiglottis margin and arytenoid region. Therefore, a resection is performed in the area of the arytenoid fold, the entrance to the piriform sinus up to the epiglottis and samples are taken from the margins. These are now tumor-free. So finally R0 resection. Defect size now indication for radial flap. Size of the flap approx. 9 x 6 cm. This is drawn on the left forearm. Drawing of a skin monitor. Lift the flap first from the ulnar and then from the radial side. Take the skin monitor and the superficial venous system with you. Locate the vascular pedicle under the brachioradialis muscle. Visualization and tracing into the crook of the elbow. After clamping the radial artery caudally, it is removed after an appropriate time with constant saturation around 100% and ligated proximally and distally using 4-0 Prolene puncture ligatures. Successive dissection of the flap with the pedicle in the direction of the antecubital fossa. Outgoing vessels are bipolarly coagulated or treated with clips. Exposure of the radial artery with entry into the brachial artery in the antecubital fossa. Also visualization of the interosseous artery. Exposure of the deep venous system with connection to the superficial venous system. Cephalic vein shows 2 larger outlets. Finally, removal of the flap. The veins are ligated. The radial artery is placed in front of the entrance to the interosseous space, preserving it, and closed using 6-0 Vascufil sutures. The cutaneous nerve to the skin island is carefully preserved and integrated into the flap to its maximum length. The flap is then irrigated with heparin solution. The flap is successively incorporated into the defect using 3-0 Vicryl single button sutures. Tension-free and complete closure. The cutaneous nerve is then dissected to just in front of the skin monitor and knocked down towards the end of the superior laryngeal nerve. Conditioning of the nerve endings. Nerve suture with 9-0 Ethilon single button sutures. Subsequent conditioning of the flap vessels with connection on the right side. The radial artery is anastomosed with the superior thyroid artery using 8-0 Ethilon single-button sutures. After opening the clamp, good arterial flow, good venous return. Both ends of the cephalic vein are conditioned. The larger outlet is anastomosed with an outlet from the facial vein. The other, smaller end of the cephalic vein is then anastomosed with a smaller outlet from the internal jugular vein, also using a 2.5 mm coupler. Good venous return in each case. Positive smear phenomenon. The thyroid gland is then stitched over the distal end of the flap and sutured to the remaining infrahyoid muscles. This protects the distal flap tip against fistula formation. Careful irrigation of the entire wound area, careful hemostasis. Knock back the apron flap. Wound closure in layers with insertion of a Redon drain on both sides. Complete epithelialization of the tracheostoma. The defect on the forearm is primarily closed cranially. To close the remaining caudal skin defect of approx. 9 x 6 cm, a 0.8 mm thick split-thickness skin graft is harvested from the right thigh using the dermatome. The skin is successively incorporated into the forearm defect. The thigh is covered with a vein dressing. The forearm is covered with a hydrogel-Mepilex dressing. Apply a cotton swab dressing on top. Wrap with absorbent cotton. Application of a Kramer splint, which is adjusted and wrapped with an elastic bandage in a functional position. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue heparin perfusor, which was started intraoperatively at 500 units per hour, for 5 days. Control of the flap via skin monitor and Doppler probe for 5 days according to the schedule. Patient should be fed via PEG tube for approx. 10 days, then gradually build up diet. As the defect in the right postcricoid region and the piriform sinus was relatively extensive due to the necessary resection and removal of marginal samples, a protracted postoperative swallowing disorder is certainly to be expected. Therefore, plan swallowing rehabilitation at an early stage. Therefore also sensitization of the radial lobe. Overall cT2-3 cN2b hypopharyngeal carcinoma on the right. Postoperative radiochemotherapy should certainly be discussed. \ No newline at end of file diff --git a/462/InvasionFront_CD3_block22_x1_y4_patient462_0.json b/462/InvasionFront_CD3_block22_x1_y4_patient462_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3bf7c2a17b829374f6dcbf35a1ab4d24fd4fab9d --- /dev/null +++ b/462/InvasionFront_CD3_block22_x1_y4_patient462_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4822.4, + "Centroid Y µm": 21313.7, + "Num Detections": 24054, + "Num Negative": 23866, + "Num Positive": 188, + "Positive %": 0.7816, + "Num Positive per mm^2": 87.28 + } +} \ No newline at end of file diff --git a/462/InvasionFront_CD3_block22_x2_y4_patient462_1.json b/462/InvasionFront_CD3_block22_x2_y4_patient462_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8ca53aec300fed1556f2c9ebd72efa4de1c26e53 --- /dev/null +++ b/462/InvasionFront_CD3_block22_x2_y4_patient462_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7471.0, + "Centroid Y µm": 21263.7, + "Num Detections": 22221, + "Num Negative": 21986, + "Num Positive": 235, + "Positive %": 1.058, + "Num Positive per mm^2": 113.0 + } +} \ No newline at end of file diff --git a/462/InvasionFront_CD8_block22_x1_y4_patient462_0.json b/462/InvasionFront_CD8_block22_x1_y4_patient462_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b1764704892c2387eb3c744bb640192a80cdee9a --- /dev/null +++ b/462/InvasionFront_CD8_block22_x1_y4_patient462_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6946.3, + "Centroid Y µm": 10519.4, + "Num Detections": 22370, + "Num Negative": 22106, + "Num Positive": 264, + "Positive %": 1.18, + "Num Positive per mm^2": 128.66 + } +} \ No newline at end of file diff --git a/462/InvasionFront_CD8_block22_x2_y4_patient462_1.json b/462/InvasionFront_CD8_block22_x2_y4_patient462_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f40f18ee8f1ae329db7ccf57f8ec4c2c5ec23930 --- /dev/null +++ b/462/InvasionFront_CD8_block22_x2_y4_patient462_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9544.9, + "Centroid Y µm": 10294.5, + "Num Detections": 21080, + "Num Negative": 20714, + "Num Positive": 366, + "Positive %": 1.736, + "Num Positive per mm^2": 182.72 + } +} \ No newline at end of file diff --git a/462/TumorCenter_CD3_block22_x1_y4_patient462_0.json b/462/TumorCenter_CD3_block22_x1_y4_patient462_0.json new file mode 100644 index 0000000000000000000000000000000000000000..62d156790f6a1f00b21c157d996e42b9faabe83e --- /dev/null +++ b/462/TumorCenter_CD3_block22_x1_y4_patient462_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4697.5, + "Centroid Y µm": 10719.3, + "Num Detections": 20618, + "Num Negative": 20497, + "Num Positive": 121, + "Positive %": 0.5869, + "Num Positive per mm^2": 57.5 + } +} \ No newline at end of file diff --git a/462/TumorCenter_CD3_block22_x2_y4_patient462_1.json b/462/TumorCenter_CD3_block22_x2_y4_patient462_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aa1991956ee0a9f23c9e77dfe8c860ac2db766cf --- /dev/null +++ b/462/TumorCenter_CD3_block22_x2_y4_patient462_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 10744.3, + "Num Detections": 19239, + "Num Negative": 19054, + "Num Positive": 185, + "Positive %": 0.9616, + "Num Positive per mm^2": 89.87 + } +} \ No newline at end of file diff --git a/462/TumorCenter_CD8_block22_x1_y4_patient462_0.json b/462/TumorCenter_CD8_block22_x1_y4_patient462_0.json new file mode 100644 index 0000000000000000000000000000000000000000..54966ad84efd9094ce43a6efe257293d82b1bd8f --- /dev/null +++ b/462/TumorCenter_CD8_block22_x1_y4_patient462_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6796.4, + "Centroid Y µm": 19664.6, + "Num Detections": 21535, + "Num Negative": 19920, + "Num Positive": 1615, + "Positive %": 7.499, + "Num Positive per mm^2": 755.09 + } +} \ No newline at end of file diff --git a/462/TumorCenter_CD8_block22_x2_y4_patient462_1.json b/462/TumorCenter_CD8_block22_x2_y4_patient462_1.json new file mode 100644 index 0000000000000000000000000000000000000000..820e7ae1185f3a0199ec32ab59e7c60dcbba3b59 --- /dev/null +++ b/462/TumorCenter_CD8_block22_x2_y4_patient462_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9170.1, + "Centroid Y µm": 19764.5, + "Num Detections": 19004, + "Num Negative": 17363, + "Num Positive": 1641, + "Positive %": 8.635, + "Num Positive per mm^2": 793.26 + } +} \ No newline at end of file diff --git a/462/history_text.txt b/462/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/462/icd_codes.txt b/462/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8942df050249e3880166bd6eaf35efe4c40f2c9 --- /dev/null +++ b/462/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] \ No newline at end of file diff --git a/462/ops_codes.txt b/462/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e07a598ba51c1acdb06a23b3f9cabaffe29b5815 --- /dev/null +++ b/462/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Pharyngotomie lateral[5-290.3 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Freier Lappen mit mikrovaskuläre Anastomose Haut und Unterhaut Empfängerstelle sonstige Teile Kopf[5-905.04 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/462/patient_clinical_data.json b/462/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d28dd6cc8008da2e84fbf170c7861c554a7c03a4 --- /dev/null +++ b/462/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 48, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/462/patient_pathological_data.json b/462/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..793a809beb8c478bce8a55aea3a92d431f4be91b --- /dev/null +++ b/462/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "462", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 54, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/462/surgery_description.txt b/462/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..99fd925854d933a7347a3f7634bf3d29da7a8e88 --- /dev/null +++ b/462/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Partial pharyngectomy, PEG, Modified radical bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheotomy diff --git a/462/surgery_report.txt b/462/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8c7a2a0ba6d52d5884046086b02525de984a073d --- /dev/null +++ b/462/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesiology colleagues, followed by entry with the small bore tube and inspection of the hypopharynx and larynx. An exophytic tumor mass was found in the area of the right piriform sinus, filling the entire piriform sinus and growing submucosally in a cranial direction. The aryepiglottic fold and the arytenoid cartilage on the right side are reached. The endolaryngeal pocket folds and vocal folds are tumor-free. The epiglottis is also tumor-free. However, the pharyngoepiglottic fold is also covered by the tumor. Esophageal entrance just clear. Then enter with the flexible esophagoscope and view into the stomach. No abnormalities here. PEG placement using the thread pull-through method with good diaphanoscopy - this was successful without any problems. Injection of Ultracaine in the neck area and sterile washing and draping. Then creation of an apron flap and start of neck dissection on the right side. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digaster muscle. Then exposure of the nervus accessorius, the facial vein and the cervical vascular sheath. Free preparation of the internal jugular vein. Exposure of the plexus branches and removal of the neck preparation II a to V a, sparing the plexus branches. Exposure of the superior thyroid artery and the external jugular vein. Then release of the cervical vascular sheath from the larynx. Separation of the superior laryngeal nerve, the artery and the superior laryngeal vein. Detachment of the thyroid gland from the larynx and change to the opposite side. Exposure of the sternocleidomastoid muscle, the omohyoid muscle and the submandibular gland. Then visualization of the facial vein and the internal jugular vein. Free preparation of the internal jugular vein. Then release of the medial neck block and visualization of the accessorius nerve and the plexus branches. Release the neck preparation II a to V a, sparing the plexus branches through and . Perform the tracheotomy. To do this, enter the trachea, after severing the thyroid isthmus, between the 2nd and 3rd tracheal cartilage and create a mucocutaneous anastomosis in the caudal region. Re-intubation and pharyngotomy on the left side. Disluxation of the epiglottis and incision of the mucosa along the edge of the epiglottis. The tumor can be seen as described above. The tumor is resected with a safety margin of at least 1 cm to 1.5 cm in the pharyngeal region. Unfortunately, nothing of the larynx can be preserved, firstly because the arytenoid cartilage is infiltrated on the right side and secondly because the thyroid cartilage is extensively infiltrated on the right side and cannot be detached from the pharynx and the tumor at all. On the left side this was achieved without any problems. Now successive excision of the tumor, taking the laryngeal preparation with it. Removal of the larynx below the cricoid cartilage. It then becomes clear that the resection in the area of the esophageal entrance was very close, a large resection is taken here and then a final marginal specimen is taken again. At the upper edge of the thyroid cartilage, the tumor is growing towards the soft tissue; here, too, the resection was very close. However, there is still a very thin, muscular displacement layer above the tumor. To be on the safe side, the infrahyoid musculature, which is located directly at this site, is resected again extensively and thickly and sent for final histology with a thread marker. The specimen is thread-marked and sent to the frozen section. In the frozen section, overall R0 situation, including the final edge sample at the esophageal entrance, this was discussed by telephone with the pathologists, a resection was not necessary at any point. A myotomy of the upper esophageal sphincter was performed. Now lifting of the radialis graft, 13 x 7 cm. Unfortunately, primary closure cannot be performed in the pharyngeal region as too little mucosa remains. The radialis graft is lifted in the usual way. First cut around the skin. Incision of the skin along the forearm up to the crook of the elbow. Then expose the venous star with the superficial venous system and locate the venous confluence with the deep venous system. Visualization of the brachioradialis muscle. Visualization of the radial superficial ramus nerve. Exposure of the radial artery. Clamping of the radial artery under pulse oximetric control - here always 100% saturation on the hand. Dissection of the radial artery and detachment of the graft from the tendons. Then dissect the pedicle in the usual way and place the radial artery graft in the crook of the elbow. Two different veins are lifted, one from the deep and one from the superficial system with preserved confluence. The graft is then sutured into the pharynx, which is of course somewhat difficult in the area of the base of the tongue and also in the area of the esophageal entrance. A pointed Z-plasty is performed here to counteract any subsequent esophageal inlet stenosis. Sutures are placed in the esophageal entrance for this purpose. Finally, the transplant is inserted with a precise fit. Repositioning to perform the anastomosis. The arterial anastomosis is performed via the superior thyroid, the venous anastomosis via the facial vein on the one hand and the external jugular vein on the other. Insertion of 2 Redon drains. Folding back of the apron flap and completion of suturing to the tracheostoma. Two-layer wound closure. At the end, another Doppler check in the area of the anastomosis and marking of the venous limb and the arterial limb for postoperative Doppler control. At the very end, another transoral inspection of the graft. This shows a very good blood supply to the graft. The operation is completed without difficulty. The patient is ventilated in the intensive care unit and is allowed to wake up the following day. Continue antibiotics for 24 hours. X-ray gruel swallow on the 10th postoperative day. If there is no fistula, please build up the diet, in the meantime feed via the PEG tube. \ No newline at end of file diff --git a/463/InvasionFront_CD3_block12_x1_y9_patient463_0.json b/463/InvasionFront_CD3_block12_x1_y9_patient463_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fad9b6a612e22045567cf771a8dcc78e2492c222 --- /dev/null +++ b/463/InvasionFront_CD3_block12_x1_y9_patient463_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3448.2, + "Centroid Y µm": 26710.9, + "Num Detections": 16945, + "Num Negative": 15199, + "Num Positive": 1746, + "Positive %": 10.3, + "Num Positive per mm^2": 785.16 + } +} \ No newline at end of file diff --git a/463/InvasionFront_CD3_block12_x2_y9_patient463_1.json b/463/InvasionFront_CD3_block12_x2_y9_patient463_1.json new file mode 100644 index 0000000000000000000000000000000000000000..461c5fccc8251df9a62197a1c45666cbc7bcd938 --- /dev/null +++ b/463/InvasionFront_CD3_block12_x2_y9_patient463_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 26760.8, + "Num Detections": 16505, + "Num Negative": 15582, + "Num Positive": 923, + "Positive %": 5.592, + "Num Positive per mm^2": 426.32 + } +} \ No newline at end of file diff --git a/463/InvasionFront_CD8_block12_x1_y9_patient463_0.json b/463/InvasionFront_CD8_block12_x1_y9_patient463_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6ef2012ed2d08a2822f35bfaabc10084308d3d75 --- /dev/null +++ b/463/InvasionFront_CD8_block12_x1_y9_patient463_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5122.3, + "Centroid Y µm": 26885.8, + "Num Detections": 17994, + "Num Negative": 17309, + "Num Positive": 685, + "Positive %": 3.807, + "Num Positive per mm^2": 308.27 + } +} \ No newline at end of file diff --git a/463/InvasionFront_CD8_block12_x2_y9_patient463_1.json b/463/InvasionFront_CD8_block12_x2_y9_patient463_1.json new file mode 100644 index 0000000000000000000000000000000000000000..51e7677a23533a6d9c462b6c86100d7fa0663e8a --- /dev/null +++ b/463/InvasionFront_CD8_block12_x2_y9_patient463_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7695.9, + "Centroid Y µm": 26635.9, + "Num Detections": 15658, + "Num Negative": 15184, + "Num Positive": 474, + "Positive %": 3.027, + "Num Positive per mm^2": 230.11 + } +} \ No newline at end of file diff --git a/463/TumorCenter_CD3_block12_x1_y9_patient463_0.json b/463/TumorCenter_CD3_block12_x1_y9_patient463_0.json new file mode 100644 index 0000000000000000000000000000000000000000..47dc8c95498d3e4567633f8583edf52e68197f01 --- /dev/null +++ b/463/TumorCenter_CD3_block12_x1_y9_patient463_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3373.2, + "Centroid Y µm": 22213.2, + "Num Detections": 16329, + "Num Negative": 15683, + "Num Positive": 646, + "Positive %": 3.956, + "Num Positive per mm^2": 296.78 + } +} \ No newline at end of file diff --git a/463/TumorCenter_CD3_block12_x2_y9_patient463_1.json b/463/TumorCenter_CD3_block12_x2_y9_patient463_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1560c7018b4fcf13d752fba4737ed4a966d0e429 --- /dev/null +++ b/463/TumorCenter_CD3_block12_x2_y9_patient463_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5946.9, + "Centroid Y µm": 22338.2, + "Num Detections": 13650, + "Num Negative": 11126, + "Num Positive": 2524, + "Positive %": 18.49, + "Num Positive per mm^2": 1465.6 + } +} \ No newline at end of file diff --git a/463/TumorCenter_CD8_block12_x1_y9_patient463_0.json b/463/TumorCenter_CD8_block12_x1_y9_patient463_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bf04a28d52c00e12a9d5e14b3a686d81c2a464e2 --- /dev/null +++ b/463/TumorCenter_CD8_block12_x1_y9_patient463_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 31208.5, + "Num Detections": 12278, + "Num Negative": 12106, + "Num Positive": 172, + "Positive %": 1.401, + "Num Positive per mm^2": 83.9 + } +} \ No newline at end of file diff --git a/463/TumorCenter_CD8_block12_x2_y9_patient463_1.json b/463/TumorCenter_CD8_block12_x2_y9_patient463_1.json new file mode 100644 index 0000000000000000000000000000000000000000..767d735b2c4008efd3383a40e61871876301cb44 --- /dev/null +++ b/463/TumorCenter_CD8_block12_x2_y9_patient463_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8845.3, + "Centroid Y µm": 31533.3, + "Num Detections": 12236, + "Num Negative": 11323, + "Num Positive": 913, + "Positive %": 7.462, + "Num Positive per mm^2": 562.85 + } +} \ No newline at end of file diff --git a/463/history_text.txt b/463/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/463/icd_codes.txt b/463/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/463/ops_codes.txt b/463/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/463/patient_clinical_data.json b/463/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d5df564eb4f707d54f7ce0207cc48dd5b620be28 --- /dev/null +++ b/463/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/463/patient_pathological_data.json b/463/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..207c678772399b194b8c492e598d962e41e9bbdf --- /dev/null +++ b/463/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "463", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.7", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/463/surgery_description.txt b/463/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f2d95551cdcf1bfff74b8d42c9d0075ce99b671b --- /dev/null +++ b/463/surgery_description.txt @@ -0,0 +1 @@ +Resection, Bilateral neck dissection diff --git a/463/surgery_report.txt b/463/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/464/InvasionFront_CD3_block7_x3_y9_patient464_0.json b/464/InvasionFront_CD3_block7_x3_y9_patient464_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9777c5a1ef622e0ef8015c99f200cbfc2281ffa4 --- /dev/null +++ b/464/InvasionFront_CD3_block7_x3_y9_patient464_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11369.0, + "Centroid Y µm": 21963.4, + "Num Detections": 19939, + "Num Negative": 18789, + "Num Positive": 1150, + "Positive %": 5.768, + "Num Positive per mm^2": 481.4 + } +} \ No newline at end of file diff --git a/464/InvasionFront_CD3_block7_x4_y9_patient464_1.json b/464/InvasionFront_CD3_block7_x4_y9_patient464_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d53e4cedcf8e6ac6ae7ea3ed360f88d0a7159b2e --- /dev/null +++ b/464/InvasionFront_CD3_block7_x4_y9_patient464_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13992.6, + "Centroid Y µm": 21938.4, + "Num Detections": 19800, + "Num Negative": 18708, + "Num Positive": 1092, + "Positive %": 5.515, + "Num Positive per mm^2": 466.39 + } +} \ No newline at end of file diff --git a/464/InvasionFront_CD8_block7_x3_y9_patient464_0.json b/464/InvasionFront_CD8_block7_x3_y9_patient464_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a3a381c89ff98a608ba1149f1c67281bc19bc3ca --- /dev/null +++ b/464/InvasionFront_CD8_block7_x3_y9_patient464_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 22887.9, + "Num Detections": 19768, + "Num Negative": 19192, + "Num Positive": 576, + "Positive %": 2.914, + "Num Positive per mm^2": 254.59 + } +} \ No newline at end of file diff --git a/464/InvasionFront_CD8_block7_x4_y9_patient464_1.json b/464/InvasionFront_CD8_block7_x4_y9_patient464_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f3702f09354da0e427da14f4913ca9def5a7a604 --- /dev/null +++ b/464/InvasionFront_CD8_block7_x4_y9_patient464_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 23212.7, + "Num Detections": 18520, + "Num Negative": 17711, + "Num Positive": 809, + "Positive %": 4.368, + "Num Positive per mm^2": 386.03 + } +} \ No newline at end of file diff --git a/464/TumorCenter_CD3_block7_x3_y9_patient464_0.json b/464/TumorCenter_CD3_block7_x3_y9_patient464_0.json new file mode 100644 index 0000000000000000000000000000000000000000..80b6f386f6c9ecacad3d41c554867e047c357634 --- /dev/null +++ b/464/TumorCenter_CD3_block7_x3_y9_patient464_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10744.3, + "Centroid Y µm": 22787.9, + "Num Detections": 12803, + "Num Negative": 12475, + "Num Positive": 328, + "Positive %": 2.562, + "Num Positive per mm^2": 185.79 + } +} \ No newline at end of file diff --git a/464/TumorCenter_CD3_block7_x4_y9_patient464_1.json b/464/TumorCenter_CD3_block7_x4_y9_patient464_1.json new file mode 100644 index 0000000000000000000000000000000000000000..36e6e5993d69697c64961100d3ce3b7aa013008b --- /dev/null +++ b/464/TumorCenter_CD3_block7_x4_y9_patient464_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 22887.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/464/TumorCenter_CD8_block7_x3_y9_patient464_0.json b/464/TumorCenter_CD8_block7_x3_y9_patient464_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8cb780da552bb30008607d24a02783ef1cdec5df --- /dev/null +++ b/464/TumorCenter_CD8_block7_x3_y9_patient464_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10519.4, + "Centroid Y µm": 22588.0, + "Num Detections": 18059, + "Num Negative": 17934, + "Num Positive": 125, + "Positive %": 0.6922, + "Num Positive per mm^2": 52.54 + } +} \ No newline at end of file diff --git a/464/TumorCenter_CD8_block7_x4_y9_patient464_1.json b/464/TumorCenter_CD8_block7_x4_y9_patient464_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c5f5bfa304ef9e95b064a8b354dfbdc074a2995 --- /dev/null +++ b/464/TumorCenter_CD8_block7_x4_y9_patient464_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13118.1, + "Centroid Y µm": 22613.0, + "Num Detections": 12516, + "Num Negative": 12349, + "Num Positive": 167, + "Positive %": 1.334, + "Num Positive per mm^2": 105.41 + } +} \ No newline at end of file diff --git a/464/history_text.txt b/464/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..37eb8cdf7526d99e9f84d5c7020236cb3357de62 --- /dev/null +++ b/464/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: With a corresponding history of noxious substances, a mass in the area of the anterior palatal arch, highly suspicious of a malignant tumor. \ No newline at end of file diff --git a/464/icd_codes.txt b/464/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..67a48458aa063e19bfa67247b126851f782b3c40 --- /dev/null +++ b/464/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren Verhaltens Mundhöhle[D37.0 R] \ No newline at end of file diff --git a/464/ops_codes.txt b/464/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d29cd1d9a8754c214fa2f42e1464a88bfccd310e --- /dev/null +++ b/464/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Lokale Exzision Mundhöhle[5-273.x R] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/464/patient_clinical_data.json b/464/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..aa2e396653b0f3a5836e99cca81fae8caec3c636 --- /dev/null +++ b/464/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 1, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/464/patient_pathological_data.json b/464/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1c5fed69cd869291fdf82e90e23869028008c3f2 --- /dev/null +++ b/464/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "464", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/464/surgery_description.txt b/464/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7fd7b8d535157b7de19a82fd7258f302c34f9962 --- /dev/null +++ b/464/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Excisional biopsy diff --git a/464/surgery_report.txt b/464/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4c5957e9d72dd7121d3ce308c8ff67f2bc3d0843 --- /dev/null +++ b/464/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Then advance the 0° optic through the glottic plane into the trachea. Further advancement to the exit of the segmental bronchi. Here the mucosal conditions are unremarkable on all sides. No evidence of pathological mucosal changes up to the glottic level. In the area of the subglottis, glottis and supraglottis, after intubation of the patient, also unremarkable mucosal conditions. Inspection of the hypopharynx on both sides and the postcricoid region: No abnormalities here either. Inspection of the base of the tongue and the oropharynx on the left side: Here too, the mucosal conditions were unremarkable. In the area of the oral cavity and in the area of the nasopharynx, after pulling up the soft palate, also no pathological mucosal changes. Advancement of the flexible endoscope into the stomach: No pathological mucosal changes in the stomach or oesophagus. Inspection of the oropharynx on the right side: A mass can be seen on the anterior surface of the anterior palatal arch, which extends to the ascending mandibular branch and extends to the glossotonsillar plica. In the area of the anterior palatal arch, this mass borders on the tonsil. If there is an urgent suspicion of malignancy and a corresponding history of noxious substances, it is decided to perform an excisional biopsy here. Cut around this mass clearly in the healthy tissue. Dissection down to the base of the tongue. Resection in healthy tissue that is clinically safe on all sides, whereby the right tonsil is also removed. The tonsil capsule is exposed and dissected down to the base of the tongue. Careful reworking in the area of the glossotonsillar fossa. Formation of a mucosal flap. Careful hemostasis. Removal of representative marginal samples. Renewed hemostasis. Completion of the procedure. Final consultation with the anesthetist. The patient is transferred to the recovery ward \ No newline at end of file diff --git a/465/InvasionFront_CD3_block3_x1_y9_patient465_0.json b/465/InvasionFront_CD3_block3_x1_y9_patient465_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f0c9dca39478266f4085b8624984ae1dfa324c9d --- /dev/null +++ b/465/InvasionFront_CD3_block3_x1_y9_patient465_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4203.9, + "Centroid Y µm": 27510.6, + "Num Detections": 8330, + "Num Negative": 6664, + "Num Positive": 1666, + "Positive %": 20.0, + "Num Positive per mm^2": 1601.7 + } +} \ No newline at end of file diff --git a/465/InvasionFront_CD3_block3_x2_y9_patient465_1.json b/465/InvasionFront_CD3_block3_x2_y9_patient465_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e7b0544a1b73c91f3317efd03053eed6dcebe393 --- /dev/null +++ b/465/InvasionFront_CD3_block3_x2_y9_patient465_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6869.2, + "Centroid Y µm": 27910.2, + "Num Detections": 17063, + "Num Negative": 13465, + "Num Positive": 3598, + "Positive %": 21.09, + "Num Positive per mm^2": 1709.9 + } +} \ No newline at end of file diff --git a/465/InvasionFront_CD8_block3_x1_y8_patient465_0.json b/465/InvasionFront_CD8_block3_x1_y8_patient465_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dc666111aa2e15f44218f3b67c8ed0c5baee363f --- /dev/null +++ b/465/InvasionFront_CD8_block3_x1_y8_patient465_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5102.5, + "Centroid Y µm": 19682.7, + "Num Detections": 18120, + "Num Negative": 16841, + "Num Positive": 1279, + "Positive %": 7.058, + "Num Positive per mm^2": 544.56 + } +} \ No newline at end of file diff --git a/465/InvasionFront_CD8_block3_x2_y8_patient465_1.json b/465/InvasionFront_CD8_block3_x2_y8_patient465_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8a782c53ded407275627bdda6c4b00198ede0335 --- /dev/null +++ b/465/InvasionFront_CD8_block3_x2_y8_patient465_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7720.9, + "Centroid Y µm": 19589.6, + "Num Detections": 19257, + "Num Negative": 17196, + "Num Positive": 2061, + "Positive %": 10.7, + "Num Positive per mm^2": 825.14 + } +} \ No newline at end of file diff --git a/465/TumorCenter_CD3_block3_x1_y8_patient465_0.json b/465/TumorCenter_CD3_block3_x1_y8_patient465_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3c5df86f22cea3cd80414edaa573477cad4e394b --- /dev/null +++ b/465/TumorCenter_CD3_block3_x1_y8_patient465_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 25936.3, + "Num Detections": 22392, + "Num Negative": 16493, + "Num Positive": 5899, + "Positive %": 26.34, + "Num Positive per mm^2": 2243.6 + } +} \ No newline at end of file diff --git a/465/TumorCenter_CD3_block3_x2_y8_patient465_1.json b/465/TumorCenter_CD3_block3_x2_y8_patient465_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ebedfd06900469d3bb12b227c48df2685c465e80 --- /dev/null +++ b/465/TumorCenter_CD3_block3_x2_y8_patient465_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 26011.2, + "Num Detections": 19194, + "Num Negative": 14229, + "Num Positive": 4965, + "Positive %": 25.87, + "Num Positive per mm^2": 2260.5 + } +} \ No newline at end of file diff --git a/465/TumorCenter_CD8_block3_x1_y8_patient465_0.json b/465/TumorCenter_CD8_block3_x1_y8_patient465_0.json new file mode 100644 index 0000000000000000000000000000000000000000..51c48720f5d05577fc406115b768c495886ae236 --- /dev/null +++ b/465/TumorCenter_CD8_block3_x1_y8_patient465_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4197.8, + "Centroid Y µm": 20464.2, + "Num Detections": 17931, + "Num Negative": 17042, + "Num Positive": 889, + "Positive %": 4.958, + "Num Positive per mm^2": 427.06 + } +} \ No newline at end of file diff --git a/465/TumorCenter_CD8_block3_x2_y8_patient465_1.json b/465/TumorCenter_CD8_block3_x2_y8_patient465_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fe0ac29b770a743e8b62b14cf87c601abb8e326f --- /dev/null +++ b/465/TumorCenter_CD8_block3_x2_y8_patient465_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 20714.0, + "Num Detections": 23182, + "Num Negative": 19690, + "Num Positive": 3492, + "Positive %": 15.06, + "Num Positive per mm^2": 1394.0 + } +} \ No newline at end of file diff --git a/465/history_text.txt b/465/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/465/icd_codes.txt b/465/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f876c5c363f6256bf9bbc29de73c88c1db48075 --- /dev/null +++ b/465/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/465/ops_codes.txt b/465/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..835395518dd91a080c3009e8f839c111a49b1fd9 --- /dev/null +++ b/465/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/465/patient_clinical_data.json b/465/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..21bbf1e1d60f0abed8095c320bca2d882e7aca1c --- /dev/null +++ b/465/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 71, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/465/patient_pathological_data.json b/465/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6ecc1dda1e49b2599b973790303b38497a75385a --- /dev/null +++ b/465/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "465", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/465/surgery_description.txt b/465/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..006b02a0de733efdd506e1816934a263841ce6b2 --- /dev/null +++ b/465/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, Tracheotomy diff --git a/465/surgery_report.txt b/465/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..21c3ba3d5900032cfd75b794c70b1222c7cb951e --- /dev/null +++ b/465/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Then, entry with the Kleinsasser tube and inspection of the tumor on the right side in the hypopharynx. The tumor is located on the medial wall of the hypopharynx and on the aryepiglottic fold. It is approx. 2 x 2 cm in size and exophytic, it can be easily adjusted, hence the decision to perform laser resection, which is then carried out. The tumor is now positioned with the spread laryngoscope and the edges of the incision are marked with a safety margin of 1.5 cm. The mucosa is then incised with the laser using 2 watts, then the laser intensity is increased to 3.5 watts and the tumor is lasered out. Care is taken to ensure that there is also a sufficient safety margin basally. In some cases, the tumor must be lasered down to the thyroid cartilage. The tumor specimen is then removed and marked in situ using a clip. The specimen is placed on cork and completely thread-marked for the frozen section. All margins are marked as R0 in the frozen section. Neck dissection on the right: repositioning of the patient by the surgeon. Injection in the area of the skin incision two fingers below the lower jaw. Care is taken to cut along the old scar line. Skin incision in the area of the old skin incision. Exposure of the platysma. This is difficult, as a clear scarring of the tissue can be seen in the area of the skin incision in the case of previous surgery. Identification of the platysma margin and subplatysmal dissection at the cranial and caudal wound margins for mobilization. Identification of the anterior margin of the sternocleidomastoid muscle and sharp dissection along the anterior margin in depth. Identification of the omohyoid muscle and sharp dissection along the muscle cranially to the hyoid bone. Identification of the submandibular gland and opening of the capsule. Carefully hold the capsule away cranially and dissect along the digastric muscle to the hyoid bone. The medial neck preparation is subtly detached from the subsurface under constant bipolar coagulation. Identification of the jugular vein and sharp dissection on the vein from caudal to cranial, so that the neck preparation is divided at the lateral-medial part. Removal of the medial neck preparation after ligation of the facial vein. Exposure of the accessory nerve and hypoglossal nerve. Gradual detachment of the lateral neck preparation from cranial to caudal, starting at level IIb while constantly protecting the surrounding structures, especially the accessorius nerve. There is a lymph node metastasis in the area of level IIb as well as in level III on the right side. The neck preparation is detached from cranial to caudal. Minor bleeding is coagulated bipolarly. The basal resection border is formed by the deep cervical fascia and the cervical plexus. The operation is completed without complications despite the overall very difficult dissection conditions due to the significant tissue scarring. Neck dissection on the left: Skin incision in a horizontal skin fold and dissection through the subcutaneous fatty tissue. Separation of the platysma and subplatysmal dissection. Exposure of the anterior border of the sternocleidomastoid muscle and exposure of this. Dissection of the omohyoid muscle up to the cranial side of the digaster muscle. Exposure of the accessorius nerve. Locate the gl. submandibularis and expose the gland. Fold up the gland and expose the digaster muscle. Dissection in the direction of level IIb. Exposure of the VJI and free preparation of the JVJ from caudal to cranial. Problem-free dissection and exposure of the facial vein. Finding and preserving the hypoglossal nerve in the jugulofacial diaper. Careful removal of the medial neck preparation while preserving all structures. Now dissection of the lateral neck preparation and removal of this while preserving the plexus branches. No increased bleeding, no chyle. Tracheotomy: Marking of the landmarks. Skin incision and dissection through the subcutaneous fatty tissue. Dissection in the linea alba on the cricoid cartilage. Move the prelaryngeal muscles to the side. Exposure of the thyroid gland and submergence of the thyroid gland with the peon clamp. Bipolar coagulation of the thyroid gland and careful transection of the thyroid gland. Move the thyroid gland to the side and expose the trachea. Opening of the trachea between the 2nd and 3rd interspace. Visor tracheotomy and suturing of the tracheostoma in the usual manner. Problem-free reintubation. \ No newline at end of file diff --git a/466/InvasionFront_CD3_block22_x3_y7_patient466_0.json b/466/InvasionFront_CD3_block22_x3_y7_patient466_0.json new file mode 100644 index 0000000000000000000000000000000000000000..467c1d110e17c8a0edad462574e00728bcbcc274 --- /dev/null +++ b/466/InvasionFront_CD3_block22_x3_y7_patient466_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12043.6, + "Centroid Y µm": 29134.6, + "Num Detections": 12548, + "Num Negative": 11812, + "Num Positive": 736, + "Positive %": 5.865, + "Num Positive per mm^2": 415.15 + } +} \ No newline at end of file diff --git a/466/InvasionFront_CD3_block22_x4_y7_patient466_1.json b/466/InvasionFront_CD3_block22_x4_y7_patient466_1.json new file mode 100644 index 0000000000000000000000000000000000000000..53b01a4eac5a2bd93676c813925d20986d821970 --- /dev/null +++ b/466/InvasionFront_CD3_block22_x4_y7_patient466_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14467.3, + "Centroid Y µm": 29109.6, + "Num Detections": 18100, + "Num Negative": 16257, + "Num Positive": 1843, + "Positive %": 10.18, + "Num Positive per mm^2": 786.4 + } +} \ No newline at end of file diff --git a/466/InvasionFront_CD8_block22_x3_y7_patient466_0.json b/466/InvasionFront_CD8_block22_x3_y7_patient466_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9528b63189508cdd749a470b16219ef0306ba1e1 --- /dev/null +++ b/466/InvasionFront_CD8_block22_x3_y7_patient466_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14460.4, + "Centroid Y µm": 17381.8, + "Num Detections": 13465, + "Num Negative": 13144, + "Num Positive": 321, + "Positive %": 2.384, + "Num Positive per mm^2": 162.53 + } +} \ No newline at end of file diff --git a/466/InvasionFront_CD8_block22_x4_y7_patient466_1.json b/466/InvasionFront_CD8_block22_x4_y7_patient466_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6ec7f54271bef96d008bb54064cbd5396ebe8f1b --- /dev/null +++ b/466/InvasionFront_CD8_block22_x4_y7_patient466_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16865.1, + "Centroid Y µm": 17413.3, + "Num Detections": 16680, + "Num Negative": 15332, + "Num Positive": 1348, + "Positive %": 8.082, + "Num Positive per mm^2": 580.56 + } +} \ No newline at end of file diff --git a/466/TumorCenter_CD3_block22_x3_y7_patient466_0.json b/466/TumorCenter_CD3_block22_x3_y7_patient466_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ecfaae2c6c1b2bba03ef2271d4930fa52eed43ea --- /dev/null +++ b/466/TumorCenter_CD3_block22_x3_y7_patient466_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11643.8, + "Centroid Y µm": 17990.5, + "Num Detections": 16672, + "Num Negative": 16107, + "Num Positive": 565, + "Positive %": 3.389, + "Num Positive per mm^2": 279.01 + } +} \ No newline at end of file diff --git a/466/TumorCenter_CD3_block22_x4_y7_patient466_1.json b/466/TumorCenter_CD3_block22_x4_y7_patient466_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3268f656162c4bdd40d77d6c2de090fcdc3caf38 --- /dev/null +++ b/466/TumorCenter_CD3_block22_x4_y7_patient466_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 18090.4, + "Num Detections": 17919, + "Num Negative": 17235, + "Num Positive": 684, + "Positive %": 3.817, + "Num Positive per mm^2": 284.34 + } +} \ No newline at end of file diff --git a/466/TumorCenter_CD8_block22_x3_y7_patient466_0.json b/466/TumorCenter_CD8_block22_x3_y7_patient466_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cf7ba657c265209d3d2a72a60d59929a0f7b1897 --- /dev/null +++ b/466/TumorCenter_CD8_block22_x3_y7_patient466_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 27410.5, + "Num Detections": 15622, + "Num Negative": 14506, + "Num Positive": 1116, + "Positive %": 7.144, + "Num Positive per mm^2": 543.05 + } +} \ No newline at end of file diff --git a/466/TumorCenter_CD8_block22_x4_y7_patient466_1.json b/466/TumorCenter_CD8_block22_x4_y7_patient466_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e33760ec527ca5f26a40c60d6101aebf9770589d --- /dev/null +++ b/466/TumorCenter_CD8_block22_x4_y7_patient466_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 27510.4, + "Num Detections": 20031, + "Num Negative": 19381, + "Num Positive": 650, + "Positive %": 3.245, + "Num Positive per mm^2": 278.04 + } +} \ No newline at end of file diff --git a/466/history_text.txt b/466/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f06bc57b187027b09b08181388577a3080c03cd3 --- /dev/null +++ b/466/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the left. This is located in the piriform sinus and just reaches the aryepiglottic fold or arytenoid cartilage. Due to the location, resection with preservation of the larynx was planned and possible. Flap coverage also necessary. Patient was informed about ...........operative necessities. \ No newline at end of file diff --git a/466/icd_codes.txt b/466/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/466/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/466/ops_codes.txt b/466/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b5af0825968ade9f226c8f3677260000f470267 --- /dev/null +++ b/466/ops_codes.txt @@ -0,0 +1 @@ +Selektive Neck dissection in 4 Regionen[5-403.03 R] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 L] Permanente Tracheostomaanlage[5-312.0 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Sonstige radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.x4 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme freier Radialis-Lappen[5-858.23 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/466/patient_clinical_data.json b/466/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..48dc61cb57848c82e024711d59575aec9d161e58 --- /dev/null +++ b/466/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/466/patient_pathological_data.json b/466/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..62cf37b9ca4af02ea646b3d02a33178d0a378f88 --- /dev/null +++ b/466/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "466", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN3", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/466/surgery_description.txt b/466/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b65a40fd98de547763c607162b104669e779b40b --- /dev/null +++ b/466/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/466/surgery_report.txt b/466/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8210a2c1228e80260ccd9fd2e0dbec587f5bda34 --- /dev/null +++ b/466/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy and laryngoscopy: The exophytic tumor is visible, which extends to the middle of the lateral wall of the left piriform sinus and extends medially to the arytenoid fold, but stops short of the arytenoid cartilage. The postcricoid area is not significantly involved. Tip of piriform sinus free macroscopically. Indication for surgery confirmed. The patient is now repositioned with all relevant surgical areas covered and disinfected. Firstly, insertion of the PEG: insertion of the flexible esophagoscope into the stomach, where no special features can be seen on rough inspection. After establishing the diaphanoscopy, insertion of a 15 mm abdominal wall tube without complications in a typical manner. Fixation to the abdominal wall in the typical manner. Subsequent insertion of an apron flap in the typical manner. Then start of radical neck dissection on the left: Large lymph node metastasis or the metastatic conglomerate, which has grown together with the sternocleidomastoid muscle and with the soft tissue in depth, is revealed. Successive dissection of the lymph node conglomerate. The internal and external carotid arteries can be dissected. The superior thyroid artery must be dissected. The facial vein must be removed, as well as signs of infiltration into the internal jugular vein, which must also be resected. The vagus nerve is also firmly attached to the tumor in the middle area and visibly infiltrated, therefore it is also resected in the middle area. The accessory nerve cannot be preserved either. The hypoglossal nerve can be dissected and preserved. Dissection of the specimen together with all affected lymph nodes. Some branches of the cervical plexus are also affected, which must also be resected. However, the majority of the plexus can be preserved. All in all, levels II to V are removed. The muscles are then removed from the hyoid bone. The hyoid bone is resected for a better overview. Entering the pharyngeal tube above the epiglottis. Exposure of the tumor. The carcinoma can be seen, which is cut around with a safety margin of 2 to 2 ˝ cm, caudally even up to 3 cm. The pharyngeal wall falls from the tonsil pole to the tip of the sinus and medially from the area of the vallecula to the posterior wall. The tumor preparation shows a tumor cone in the direction of the laryngeal skeleton, but this can be dissected off in healthy tissue. The arytenoid cartilage is partially de-epithelialized at the edge. Here the tumor is somewhat closer than at the other margins, therefore a separate marginal sample is taken from the vallecula over the arytenoid region down to the piriform sinus entrance. Likewise, a marginal sample is taken basally from the soft parts of the larynx where the tumor cone reached. The tumor specimen is also sent in thread-marked for frozen section. Both edge samples are healthy, in the area of the tumor preparation there is still small, infiltrating tumor growth towards the tip of the sinus, where the largest safety distance was. Therefore, another approx. 1 cm wide marginal sample is taken from this area, which is marked remote from the tumor. No more infiltrates in the frozen section. However, there is moderate dysplasia in the entire mucosal area at the edge. Overall, a satellite-like, wallpaper-like, mosaic-like growth can be assumed. Due to the locally existing R0 resection, however, no more resections. Excision biopsy of a calcified thyroid nodule from the left lobe. Now palpation of the thyroid nodule on the left side. This is approx. 1.5 cm in diameter. Hard consistency. The tumor is now removed from the left lobe of the thyroid gland via an incision. Then careful hemostasis and closure of the thyroid lobe with 2-0 Vicryl single button sutures. The neck is now dissected on the right side: after exposing the omohyoid, digastric and sternocleidomastoid muscles, levels II to IV and parts of V a and b are removed. The internal and external carotid arteries and outgoing arteries as well as the facial vein, internal jugular vein, vagus nerve, hypoglossal nerve and accessorius nerve and the branches of the cervical plexus are all exposed and preserved. Surgery was performed by . Subsequent tracheostoma creation by : After cutting the infrahyoid muscles, the thyroid isthmus is exposed. This is passed underneath, clamped off, severed and supplied in a typical manner using puncture ligatures. The trachea is then exposed. A modified, broadly pedicled Björk flap is created between the 2nd and 3rd cartilage. This is first epithelialized caudally. Subsequent reintubation. Tracheotomy was already performed before the final tumor resection. Then, after ensuring R0 resection, flap removal on the left forearm: Marking of the flap size, this is 10 x 8 cm. Marking of a skin monitor. Then first cut around the flap and the skin monitor as well as subcutaneous tissue subfascially from the ulna, then extend the incision into the crook of the elbow ..................................... Exposure of the superficial venous system with connection to the deep venous system. Subsequent incision of the flap from radial, subfascial. Exposure of the superficial cutaneous antebrachial nerve. Then exposure of the radial artery distally. Clamping of this. This is done for approx. 10 minutes, with stable saturation. Further removal of the flap in between. The radial artery is then removed. This is treated proximally and distally using 4-0 Prolene stitches. Lifting of the flap subfascially. Smaller arteries extending from the pedicle are clipped or bipolar coagulated. Dissection including the superficial venous system and the deep pedicle. A good but clearly medially located cephalic vein with 2 ends can be dissected in the antecubital fossa. The radial artery is dissected up to the entrance to the brachial artery. After clamping, the interosseous artery is left for a few minutes and closed with clips. The artery is then removed first. This is closed with 6-0 Vascufil sutures towards the brachial artery. Clamp and ligature the veins. The flap is then flushed with heparin solution. The arm is then closed in layers in the cranial area after careful hemostasis. A 0.7 to 0.8 mm thick split-thickness skin graft was obtained from the thigh, which is now successively incorporated into the forearm defect. Here complete closure. Sewing on swabs. Application of octenidine gel and application of cloud compresses. Then wrap with absorbent cotton. Fitting of a Kramer splint and fixation with an elastic bandage. Re-application of the arm. Saturation always close to or at 100% until the end of the operation. Subsequent insertion of the flap into the defect. The flap is inserted in such a way that the stalk on the opposite side can be anastomosed with the vessels. Successive suturing of the flap into the defect, partly with the sutures in place, using 3-0 Vicryl single-button sutures. The defect is closed without tension. The stalk is transferred to the opposite side. The superior thyroid artery is shown here. This is sutured to the radial artery after appropriate conditioning using 8-0 Vicryl single button sutures. Due to the different lumen, this must be done twice before a ......................... pulsation of the pedicle can be achieved. Then dissection of the 2 venous outlets from the superficial venous system and 2 outlets from the area of the facial vein. After conditioning, the first larger vein is anastomosed with the outgoing facial vein using a 4-0 coupler. The smaller outlet is also anastomosed with the smaller outlet from the stalk using a 2.5 mm coupler. Good venous return after opening the clamps in each case, positive smear phenomenon. After completion of the vascular anastomoses, strong pulse in the pedicle area and venous return. Subsequent positioning of the pedicle, careful irrigation and hemostasis. Wound closure by retraction of the apron flap. Caudal completion of the epithelialization of the stoma. Lateral cervical closure on the left by placing a Redon drainage, on the right by placing 2 flaps. Re-intubation and insertion of an 8 mm tracheostomy tube. This is fixed with sutures. At the end of the operation, arterial and venous flow could be observed very well with the Doppler. The skin monitor was sutured into the apron flap via a small incision in the ventral neck skin without tension and also showed a very good aspect. The procedure was completed without complications. Patient received Unacid 3 g preoperatively and again during the operation. Antibiotics should be continued for 1 week. Nutrition should be provided via the PEG tube already in place for at least 10 days. Then gruel should be swallowed and, if necessary, the diet should be built up. Heparin perfusor therapy started intraoperatively at 500 units per hour should be continued postoperatively for 5 days. Doppler control according to the scheme for 5 days incl. assessment of the skin monitor. Change the dressing on the forearm, if possible, only after 5 to 7 days. The hydrogel thigh bandage that was finally applied can be left in place for 3 to 4 days or changed depending on the findings. Please loosen the PEG the next day in the typical manner. Wait for the histology from the left lobe of the thyroid gland and then proceed according to the findings. Overall cT2 to 3 hypopharyngeal carcinoma on the left with infiltration up to the edge of the larynx. Therefore, the epiglottis margin, aryepiglottic fold, vallecula and parts of the laryngeal skeleton were also removed. Flap coverage by means of a radial flap. Extensive left cervical lymph node metastasis. Therefore, postoperative presentation in the interdisciplinary tumor conference on the question of postoperative radiochemotherapy. Due to the surgical measures, initiate swallowing rehabilitation at an early stage. \ No newline at end of file diff --git a/467/InvasionFront_CD3_block2_x1_y4_patient467_0.json b/467/InvasionFront_CD3_block2_x1_y4_patient467_0.json new file mode 100644 index 0000000000000000000000000000000000000000..79cc5b7287dd952d2f8fc5df10f78b5ec5018806 --- /dev/null +++ b/467/InvasionFront_CD3_block2_x1_y4_patient467_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 23312.7, + "Num Detections": 19732, + "Num Negative": 13659, + "Num Positive": 6073, + "Positive %": 30.78, + "Num Positive per mm^2": 2633.8 + } +} \ No newline at end of file diff --git a/467/InvasionFront_CD3_block2_x2_y4_patient467_1.json b/467/InvasionFront_CD3_block2_x2_y4_patient467_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f2086a3956f6067cf5b623bf6de580ec95288a35 --- /dev/null +++ b/467/InvasionFront_CD3_block2_x2_y4_patient467_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9095.2, + "Centroid Y µm": 23437.6, + "Num Detections": 18324, + "Num Negative": 13461, + "Num Positive": 4863, + "Positive %": 26.54, + "Num Positive per mm^2": 2352.6 + } +} \ No newline at end of file diff --git a/467/InvasionFront_CD8_block2_x1_y4_patient467_0.json b/467/InvasionFront_CD8_block2_x1_y4_patient467_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42426c0037bb8ef1a4d2f89292fcf6df31157807 --- /dev/null +++ b/467/InvasionFront_CD8_block2_x1_y4_patient467_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5322.2, + "Centroid Y µm": 11019.2, + "Num Detections": 19878, + "Num Negative": 14366, + "Num Positive": 5512, + "Positive %": 27.73, + "Num Positive per mm^2": 2432.0 + } +} \ No newline at end of file diff --git a/467/InvasionFront_CD8_block2_x2_y4_patient467_1.json b/467/InvasionFront_CD8_block2_x2_y4_patient467_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d8fc2b22f9c7266a36e839fa5daa6906441d4277 --- /dev/null +++ b/467/InvasionFront_CD8_block2_x2_y4_patient467_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7895.8, + "Centroid Y µm": 11069.1, + "Num Detections": 22411, + "Num Negative": 19029, + "Num Positive": 3382, + "Positive %": 15.09, + "Num Positive per mm^2": 1447.8 + } +} \ No newline at end of file diff --git a/467/TumorCenter_CD3_block2_x1_y4_patient467_0.json b/467/TumorCenter_CD3_block2_x1_y4_patient467_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8eea757329694cfa1eeba5d0a325d1de16f80410 --- /dev/null +++ b/467/TumorCenter_CD3_block2_x1_y4_patient467_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4472.6, + "Centroid Y µm": 9420.0, + "Num Detections": 19126, + "Num Negative": 12761, + "Num Positive": 6365, + "Positive %": 33.28, + "Num Positive per mm^2": 2719.7 + } +} \ No newline at end of file diff --git a/467/TumorCenter_CD3_block2_x2_y4_patient467_1.json b/467/TumorCenter_CD3_block2_x2_y4_patient467_1.json new file mode 100644 index 0000000000000000000000000000000000000000..815b7febe295ac8b795bdc4be09eb4d98d7e0f4b --- /dev/null +++ b/467/TumorCenter_CD3_block2_x2_y4_patient467_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7021.3, + "Centroid Y µm": 9520.0, + "Num Detections": 20534, + "Num Negative": 14980, + "Num Positive": 5554, + "Positive %": 27.05, + "Num Positive per mm^2": 2321.6 + } +} \ No newline at end of file diff --git a/467/TumorCenter_CD8_block2_x1_y4_patient467_0.json b/467/TumorCenter_CD8_block2_x1_y4_patient467_0.json new file mode 100644 index 0000000000000000000000000000000000000000..36b3e9af55148a7eba8dd61fe8caa305e7bc4b93 --- /dev/null +++ b/467/TumorCenter_CD8_block2_x1_y4_patient467_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 9769.8, + "Num Detections": 21582, + "Num Negative": 17749, + "Num Positive": 3833, + "Positive %": 17.76, + "Num Positive per mm^2": 1649.3 + } +} \ No newline at end of file diff --git a/467/TumorCenter_CD8_block2_x2_y4_patient467_1.json b/467/TumorCenter_CD8_block2_x2_y4_patient467_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b6679b933896fcbff6ecce0a6ad9374dee97c022 --- /dev/null +++ b/467/TumorCenter_CD8_block2_x2_y4_patient467_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8370.6, + "Centroid Y µm": 9694.9, + "Num Detections": 22040, + "Num Negative": 19056, + "Num Positive": 2984, + "Positive %": 13.54, + "Num Positive per mm^2": 1261.5 + } +} \ No newline at end of file diff --git a/467/history_text.txt b/467/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c52f55b4b3c7617a045d6bad1b2f6aa9f83a339f --- /dev/null +++ b/467/history_text.txt @@ -0,0 +1 @@ +A squamous cell carcinoma in the area of the left tonsil was confirmed externally in the patient. Now indication for the above-mentioned procedure. \ No newline at end of file diff --git a/467/icd_codes.txt b/467/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7cad4b2d094291b226dabcbc245348c480f5519e --- /dev/null +++ b/467/icd_codes.txt @@ -0,0 +1 @@ +Ausfall vom 10.03.Bösartige Neubildung: Seitenwand des Oropharynx[C10.2 ] Karzinom Oropharynx Seitenwand[C10.2 L] \ No newline at end of file diff --git a/467/ops_codes.txt b/467/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..13bf203f05fe2ccd4a38a47e54afb933a4de83da --- /dev/null +++ b/467/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision am Pharynx[5-292.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/467/patient_clinical_data.json b/467/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2cd752ec3eaf88c61cd1e6876b76a11e24b78929 --- /dev/null +++ b/467/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/467/patient_pathological_data.json b/467/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4ea326ef8e239137272c716cfeb795c5601270ea --- /dev/null +++ b/467/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "467", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/467/surgery_description.txt b/467/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc48809d686f16957662656ed78a1638c073a4ee --- /dev/null +++ b/467/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy, Panendoscopy, Tracheotomy, PEG placement diff --git a/467/surgery_report.txt b/467/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..460999b70df89338a5fc859fb572bef0d47fb5f6 --- /dev/null +++ b/467/surgery_report.txt @@ -0,0 +1 @@ +Tracheoscopy. No abnormalities here. Perform panendoscopy. Enter with the Kleinsasser tube and inspect the hypopharynx and larynx. No abnormalities here. Perform an oropharyngoscopy. There is a rough mass in the area of the left tonsil that extends to the soft palate as well as to the anterior and posterior palatal arch and cannot be moved. Marking of the incision margins and incision of the mucosa with the monopolar needle. Part of the soft palate on the left must be resected. Successive dissection of the tumor with removal of a small muscle margin in the depth. The anterior palatal arch must be resected completely, the posterior palatal arch partially and a small area of the base of the tongue. The specimen is thread-marked and sent to the frozen section. All edges are tumor-free in the frozen section. In the meantime, the PEG is inserted. Entering with the flexible esophagoscope and pre-mirroring into the stomach. Oesophagus and stomach unremarkable. If the diaphanoscopy is good, perform the PEG insertion using the thread pull-through method. Due to the very large wound area in the oropharynx, perform a small tracheostomy. Skin incision below the cricoid cartilage for this. Exposure of the musculature. Splitting of the musculature in the linea alba. Exposure of the thyroid gland. Undermining of the thyroid gland. Dissection of the thyroid gland. After bipolar coagulation, exposure of the anterior wall of the trachea. Entering the trachea between the second and third tracheal cartilages. Creation of a visor tracheotomy. Creation of a mucocutaneous anastomosis. Caudal and cranial insertion of an 8 mm tracheal cannula. Completion of the procedure without complication. Waiting for the final histology and planning of a neck dissection on both sides. Subsequent presentation at the tumor conference. \ No newline at end of file diff --git a/468/InvasionFront_CD3_block14_x3_y11_patient468_0.json b/468/InvasionFront_CD3_block14_x3_y11_patient468_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e077bbfcc352e23eb9aa791a1606fc30ae57d682 --- /dev/null +++ b/468/InvasionFront_CD3_block14_x3_y11_patient468_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 31308.4, + "Num Detections": 14342, + "Num Negative": 14191, + "Num Positive": 151, + "Positive %": 1.053, + "Num Positive per mm^2": 97.71 + } +} \ No newline at end of file diff --git a/468/InvasionFront_CD3_block14_x4_y11_patient468_1.json b/468/InvasionFront_CD3_block14_x4_y11_patient468_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd80bd3f6d8f37fbd48660e0691de1141fc6024b --- /dev/null +++ b/468/InvasionFront_CD3_block14_x4_y11_patient468_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 31508.3, + "Num Detections": 15881, + "Num Negative": 15448, + "Num Positive": 433, + "Positive %": 2.727, + "Num Positive per mm^2": 238.73 + } +} \ No newline at end of file diff --git a/468/InvasionFront_CD8_block14_x3_y11_patient468_0.json b/468/InvasionFront_CD8_block14_x3_y11_patient468_0.json new file mode 100644 index 0000000000000000000000000000000000000000..483a5d50500c8a80cd0239025e455067fde02d56 --- /dev/null +++ b/468/InvasionFront_CD8_block14_x3_y11_patient468_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11618.8, + "Centroid Y µm": 26885.8, + "Num Detections": 17363, + "Num Negative": 17022, + "Num Positive": 341, + "Positive %": 1.964, + "Num Positive per mm^2": 176.63 + } +} \ No newline at end of file diff --git a/468/InvasionFront_CD8_block14_x4_y11_patient468_1.json b/468/InvasionFront_CD8_block14_x4_y11_patient468_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b3367a25b5c2a622e95b5935a7864ed1b3ec6305 --- /dev/null +++ b/468/InvasionFront_CD8_block14_x4_y11_patient468_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14042.6, + "Centroid Y µm": 27010.7, + "Num Detections": 17423, + "Num Negative": 16565, + "Num Positive": 858, + "Positive %": 4.925, + "Num Positive per mm^2": 420.28 + } +} \ No newline at end of file diff --git a/468/TumorCenter_CD3_block14_x3_y11_patient468_0.json b/468/TumorCenter_CD3_block14_x3_y11_patient468_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6e6fbadb6e08e1bfd7f97edf7d6518eb3f5799a0 --- /dev/null +++ b/468/TumorCenter_CD3_block14_x3_y11_patient468_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 27785.3, + "Num Detections": 18649, + "Num Negative": 17684, + "Num Positive": 965, + "Positive %": 5.175, + "Num Positive per mm^2": 431.7 + } +} \ No newline at end of file diff --git a/468/TumorCenter_CD3_block14_x4_y11_patient468_1.json b/468/TumorCenter_CD3_block14_x4_y11_patient468_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dcd55a5ed7de33799505fccff1395a9cc94db231 --- /dev/null +++ b/468/TumorCenter_CD3_block14_x4_y11_patient468_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 27885.2, + "Num Detections": 19750, + "Num Negative": 17717, + "Num Positive": 2033, + "Positive %": 10.29, + "Num Positive per mm^2": 863.75 + } +} \ No newline at end of file diff --git a/468/TumorCenter_CD8_block14_x3_y11_patient468_0.json b/468/TumorCenter_CD8_block14_x3_y11_patient468_0.json new file mode 100644 index 0000000000000000000000000000000000000000..912226f643efeb879c79ec2e69c6f7ba7d806357 --- /dev/null +++ b/468/TumorCenter_CD8_block14_x3_y11_patient468_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10469.5, + "Centroid Y µm": 27860.2, + "Num Detections": 18443, + "Num Negative": 17588, + "Num Positive": 855, + "Positive %": 4.636, + "Num Positive per mm^2": 422.22 + } +} \ No newline at end of file diff --git a/468/TumorCenter_CD8_block14_x4_y11_patient468_1.json b/468/TumorCenter_CD8_block14_x4_y11_patient468_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d38619ce42e583bd65e552b4719d59f82f64fcf --- /dev/null +++ b/468/TumorCenter_CD8_block14_x4_y11_patient468_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13043.1, + "Centroid Y µm": 27985.2, + "Num Detections": 20464, + "Num Negative": 18150, + "Num Positive": 2314, + "Positive %": 11.31, + "Num Positive per mm^2": 976.5 + } +} \ No newline at end of file diff --git a/468/history_text.txt b/468/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/468/icd_codes.txt b/468/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c4cbe264723806b0b814fa5e9ae9fd3a8549a61 --- /dev/null +++ b/468/icd_codes.txt @@ -0,0 +1 @@ +Karzinom des Zungenrandes und der Zungenspitze[C02.1 L] \ No newline at end of file diff --git a/468/ops_codes.txt b/468/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3c5ec699c6924f1fa55f4ef81271cc0b08d366fd --- /dev/null +++ b/468/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/468/patient_clinical_data.json b/468/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0c36342b016920339b03233dbe86fbe04d4519b7 --- /dev/null +++ b/468/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 76, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/468/patient_pathological_data.json b/468/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..095c4830985c06a8ad1614f36ecd1371df0f2bd2 --- /dev/null +++ b/468/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "468", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": null, + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/468/surgery_description.txt b/468/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..036f3bfa8e2effd1f846262ad6bdcc81e710fae7 --- /dev/null +++ b/468/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Pharyngoscopy, Laryngoscopy diff --git a/468/surgery_report.txt b/468/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f681c795884b402178fc1d2cff640c62b63e419c --- /dev/null +++ b/468/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia. Intubation by the anesthesia colleagues. Inspection of the tumor region using narrow band imaging. An oval structure is seen in the anterior third of the edge of the tongue on the left side. This is examined using NBI and contact endoscopy. There are also whitish changes on the floor of the mouth, which were previously described by dermatologists as lichen ruber planus. Biopsies are taken again from all sides. ThenZZZZn the tongue and cut around the tumor, first with a monopolar needle, then with scissors and tweezers. The tumor specimen is removed in its entirety. Then marginal samples are taken from the tumor and sent for frozen section. The tumor specimen shows R0 on all sides, with slight dysplasia in the lateral area. However, the pathologists are ultimately unable to rule out carcinoma in situ and recommend a resection. This is carried out. Hemostasis by means of bipolar coagulation and completion of the procedure without complications. \ No newline at end of file diff --git a/469/InvasionFront_CD3_block5_x5_y5_patient469_0.json b/469/InvasionFront_CD3_block5_x5_y5_patient469_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f66e9c0190dca55de0af0ef135ef7e79ab9b32a --- /dev/null +++ b/469/InvasionFront_CD3_block5_x5_y5_patient469_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16451.7, + "Centroid Y µm": 13011.6, + "Num Detections": 10032, + "Num Negative": 9929, + "Num Positive": 103, + "Positive %": 1.027, + "Num Positive per mm^2": 85.82 + } +} \ No newline at end of file diff --git a/469/InvasionFront_CD3_block5_x6_y5_patient469_1.json b/469/InvasionFront_CD3_block5_x6_y5_patient469_1.json new file mode 100644 index 0000000000000000000000000000000000000000..86f19db2ababce27ff6942d465d1c76a2ad03174 --- /dev/null +++ b/469/InvasionFront_CD3_block5_x6_y5_patient469_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19139.9, + "Centroid Y µm": 13143.0, + "Num Detections": 18590, + "Num Negative": 18425, + "Num Positive": 165, + "Positive %": 0.8876, + "Num Positive per mm^2": 84.47 + } +} \ No newline at end of file diff --git a/469/InvasionFront_CD8_block5_x5_y4_patient469_0.json b/469/InvasionFront_CD8_block5_x5_y4_patient469_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f0705e2817c9a485b4707739c6f094ad038f0bb --- /dev/null +++ b/469/InvasionFront_CD8_block5_x5_y4_patient469_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16464.7, + "Centroid Y µm": 10464.0, + "Num Detections": 10610, + "Num Negative": 10022, + "Num Positive": 588, + "Positive %": 5.542, + "Num Positive per mm^2": 486.53 + } +} \ No newline at end of file diff --git a/469/InvasionFront_CD8_block5_x6_y4_patient469_1.json b/469/InvasionFront_CD8_block5_x6_y4_patient469_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0950ea41cd72fa24fd02534c9dbb590b8e1815b --- /dev/null +++ b/469/InvasionFront_CD8_block5_x6_y4_patient469_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18710.2, + "Centroid Y µm": 9779.1, + "Num Detections": 20892, + "Num Negative": 19579, + "Num Positive": 1313, + "Positive %": 6.285, + "Num Positive per mm^2": 578.04 + } +} \ No newline at end of file diff --git a/469/TumorCenter_CD3_block5_x5_y4_patient469_0.json b/469/TumorCenter_CD3_block5_x5_y4_patient469_0.json new file mode 100644 index 0000000000000000000000000000000000000000..badd669d65bb272abd70af6f5f6bb668858e31d9 --- /dev/null +++ b/469/TumorCenter_CD3_block5_x5_y4_patient469_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17590.7, + "Centroid Y µm": 10469.5, + "Num Detections": 21365, + "Num Negative": 18679, + "Num Positive": 2686, + "Positive %": 12.57, + "Num Positive per mm^2": 1122.3 + } +} \ No newline at end of file diff --git a/469/TumorCenter_CD3_block5_x6_y4_patient469_1.json b/469/TumorCenter_CD3_block5_x6_y4_patient469_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b215fefa4823c73e17b195e7792eb99864d10e0e --- /dev/null +++ b/469/TumorCenter_CD3_block5_x6_y4_patient469_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20239.3, + "Centroid Y µm": 10644.4, + "Num Detections": 24936, + "Num Negative": 22868, + "Num Positive": 2068, + "Positive %": 8.293, + "Num Positive per mm^2": 778.61 + } +} \ No newline at end of file diff --git a/469/TumorCenter_CD8_block5_x5_y4_patient469_0.json b/469/TumorCenter_CD8_block5_x5_y4_patient469_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6d2456972e9ce38dc785ed798431b023eacc423d --- /dev/null +++ b/469/TumorCenter_CD8_block5_x5_y4_patient469_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 10119.6, + "Num Detections": 23295, + "Num Negative": 21707, + "Num Positive": 1588, + "Positive %": 6.817, + "Num Positive per mm^2": 653.47 + } +} \ No newline at end of file diff --git a/469/TumorCenter_CD8_block5_x6_y4_patient469_1.json b/469/TumorCenter_CD8_block5_x6_y4_patient469_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f73065605423378d35c384f2f6cf95b5a189715e --- /dev/null +++ b/469/TumorCenter_CD8_block5_x6_y4_patient469_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 10169.6, + "Num Detections": 27032, + "Num Negative": 26334, + "Num Positive": 698, + "Positive %": 2.582, + "Num Positive per mm^2": 264.64 + } +} \ No newline at end of file diff --git a/469/history_text.txt b/469/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/469/icd_codes.txt b/469/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..60baf9cf45b7cc63d0cdf4e5c0eacf62177a45b5 --- /dev/null +++ b/469/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 B] \ No newline at end of file diff --git a/469/ops_codes.txt b/469/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..95f235b576a7b01cc48a529c738efccc38194de4 --- /dev/null +++ b/469/ops_codes.txt @@ -0,0 +1 @@ +Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Temporäre Tracheotomie[5-311.0 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] CO2-Lasertechnik[5-985.1 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] \ No newline at end of file diff --git a/469/patient_clinical_data.json b/469/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..210c68f376b73df6c2072b15fea263adb2841ac1 --- /dev/null +++ b/469/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/469/patient_pathological_data.json b/469/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..075a023206613345269c19767cf5fba9399801a1 --- /dev/null +++ b/469/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "469", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/469/surgery_description.txt b/469/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..76516399d4f5bb37873aa8ed579838cfdd162b10 --- /dev/null +++ b/469/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/469/surgery_report.txt b/469/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..43ca6a634ef45bda03faeb47539d698a06c99380 --- /dev/null +++ b/469/surgery_report.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the oropharynx. Pharyngoscopy and laryngoscopy again before surgery: the exophytic, partly ulcerating tumor is seen, which is located on the epiglottis, partly growing through it from the vallecula on the right over the midline into the vallecula region on the left. Base of tongue not affected macroscopically. First tracheotomy: small Kocher's collar incision, then splitting of the infrahyoid muscles and exposure of the thyroid gland. Dissection of the thyroid gland, which is stitched and ligated. Subsequent exposure of the trachea. A small, modified Björk flap is created and epithelized in the 2nd/3rd tracheal space. Re-intubation. Subsequent PEG placement: insertion into the stomach. After diaphanoscopy, insertion of a 15 mm stomach wall tube without complications. This is then fixed in the typical manner. Subsequent laser resection: tumor can be adjusted. The tumor is successively cut around on all sides with the laser at a distance of at least 1 cm. The caudal base of the tongue and a large part of the arytenoid fold on the right, the entire vallecula area, the entire epiglottis and arytenoid fold on the left are partially removed. Tumor is thread-marked. Resection also extended to the pre-epiglottic soft tissue, which was also partially removed. Subsequently, a marginal specimen from the caudal-basal area with epiglottis pedicle and soft tissue towards the pre-epiglottis. Subsequently, soft tissues of the vallecula. Both extend from left to right and are marked with sutures. In the frozen section, tumor preparation as well as marginal samples in healthy tissue, thus R0 resection. Now careful hemostasis. Removal of all swabs. Removal of the mouthguard and removal of the spreading laryngoscope. Subsequent repositioning for neck dissection: first disinfect the skin, inject a total of 10 ml Ultracaine 1% with adrenaline into both sides of the neck. Sterile draping. Start with neck dissection on the left: Skin incision in typical manner. Exposure of digastric muscle, omohyoid muscle, sternocleidomastoid muscle. Subsequent exposure of facial vein, internal jugular vein, carotid artery, vagus nerve, hypoglossal nerve, accessorius nerve and border cord. Level II to V evacuation with exposure and preservation of the above structures and exposure and preservation of the branches of the cervical plexus. Subsequent operation on the right side: in principle the same procedure here. Positive lymph node clearly in level IV. Overall removal of levels II to V with dissection and preservation of the structures as on the opposite side. Subsequently, careful hemostasis and irrigation with H2O2 and Ringer's solution on both sides. No more bleeding on final inspection. Wound closure in layers on both sides and insertion of a Redon drain. Re-intubation and insertion of an 8-gauge tracheostomy tube. Overall cT2 to 3 squamous cell carcinoma of the vallecula or epiglottis and supraglottic area. Positive lymph node on the right. PEG tract loosening after 24 hours in a typical manner. Then initially nutrition via PEG. Continue antibiotics for a total of 2 days postoperatively with Unacid. At least temporary dysphagia to be expected, therefore early swallowing training, if necessary presentation to swallowing rehab. With regard to the further therapeutic procedure, wait for the final histology and presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/470/InvasionFront_CD3_block10_x3_y1_patient470_0.json b/470/InvasionFront_CD3_block10_x3_y1_patient470_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0b00be701d1bd7f845b0433c49a1c10fbe31f587 --- /dev/null +++ b/470/InvasionFront_CD3_block10_x3_y1_patient470_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14431.3, + "Centroid Y µm": 7978.0, + "Num Detections": 16105, + "Num Negative": 15763, + "Num Positive": 342, + "Positive %": 2.124, + "Num Positive per mm^2": 174.88 + } +} \ No newline at end of file diff --git a/470/InvasionFront_CD3_block10_x4_y1_patient470_1.json b/470/InvasionFront_CD3_block10_x4_y1_patient470_1.json new file mode 100644 index 0000000000000000000000000000000000000000..026954794187aca08a6f2477362f7c2728226156 --- /dev/null +++ b/470/InvasionFront_CD3_block10_x4_y1_patient470_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16802.3, + "Centroid Y µm": 8035.9, + "Num Detections": 13868, + "Num Negative": 13314, + "Num Positive": 554, + "Positive %": 3.995, + "Num Positive per mm^2": 328.56 + } +} \ No newline at end of file diff --git a/470/InvasionFront_CD8_block10_x3_y1_patient470_0.json b/470/InvasionFront_CD8_block10_x3_y1_patient470_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d758aac047ef4df77d3504ac9b26201e9a592013 --- /dev/null +++ b/470/InvasionFront_CD8_block10_x3_y1_patient470_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 7795.9, + "Num Detections": 17524, + "Num Negative": 16993, + "Num Positive": 531, + "Positive %": 3.03, + "Num Positive per mm^2": 251.13 + } +} \ No newline at end of file diff --git a/470/InvasionFront_CD8_block10_x4_y1_patient470_1.json b/470/InvasionFront_CD8_block10_x4_y1_patient470_1.json new file mode 100644 index 0000000000000000000000000000000000000000..92cbfdce5393b975355c3883ec4fbf5e08e097a1 --- /dev/null +++ b/470/InvasionFront_CD8_block10_x4_y1_patient470_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15566.8, + "Centroid Y µm": 7970.8, + "Num Detections": 14559, + "Num Negative": 13971, + "Num Positive": 588, + "Positive %": 4.039, + "Num Positive per mm^2": 342.21 + } +} \ No newline at end of file diff --git a/470/TumorCenter_CD3_block10_x3_y1_patient470_0.json b/470/TumorCenter_CD3_block10_x3_y1_patient470_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6c4b5098877c085c53607acce5c3c06cba9bfd62 --- /dev/null +++ b/470/TumorCenter_CD3_block10_x3_y1_patient470_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 2623.6, + "Num Detections": 13380, + "Num Negative": 12974, + "Num Positive": 406, + "Positive %": 3.034, + "Num Positive per mm^2": 193.45 + } +} \ No newline at end of file diff --git a/470/TumorCenter_CD3_block10_x4_y1_patient470_1.json b/470/TumorCenter_CD3_block10_x4_y1_patient470_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69952fbbfbca9b3aff9a0e772cabcf31b683175b --- /dev/null +++ b/470/TumorCenter_CD3_block10_x4_y1_patient470_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 2498.7, + "Num Detections": 18519, + "Num Negative": 17667, + "Num Positive": 852, + "Positive %": 4.601, + "Num Positive per mm^2": 357.38 + } +} \ No newline at end of file diff --git a/470/TumorCenter_CD8_block10_x3_y1_patient470_0.json b/470/TumorCenter_CD8_block10_x3_y1_patient470_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2beda37bfa063f3e34e6771268b0688431dfbdf1 --- /dev/null +++ b/470/TumorCenter_CD8_block10_x3_y1_patient470_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10494.4, + "Centroid Y µm": 3123.3, + "Num Detections": 14898, + "Num Negative": 14047, + "Num Positive": 851, + "Positive %": 5.712, + "Num Positive per mm^2": 381.95 + } +} \ No newline at end of file diff --git a/470/TumorCenter_CD8_block10_x4_y1_patient470_1.json b/470/TumorCenter_CD8_block10_x4_y1_patient470_1.json new file mode 100644 index 0000000000000000000000000000000000000000..957dabebf80defae12ce79f8451678f594d310c0 --- /dev/null +++ b/470/TumorCenter_CD8_block10_x4_y1_patient470_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12893.2, + "Centroid Y µm": 3048.4, + "Num Detections": 20035, + "Num Negative": 18477, + "Num Positive": 1558, + "Positive %": 7.776, + "Num Positive per mm^2": 676.73 + } +} \ No newline at end of file diff --git a/470/history_text.txt b/470/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1991da23f96d39095acbfdf1896da84959cd0d1a --- /dev/null +++ b/470/history_text.txt @@ -0,0 +1 @@ +A cT2 cN2c oral cavity carcinoma was histologically confirmed in the patient during a panendoscopy. Sonographically cN2c neck status, in CT imaging cN0 neck status. In our interdisciplinary tumor conference, the primary surgical treatment was decided. \ No newline at end of file diff --git a/470/icd_codes.txt b/470/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/470/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/470/ops_codes.txt b/470/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa35e6c194a7cbb065c53e235167e5543668ccaa --- /dev/null +++ b/470/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen sonstige[5-858.7x R] Direkte Hypopharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Anlegen einer PEG[5-431.2 ] Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Kontinuierliche Sogbehandlung mit sonstigen Systemen bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.30 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] \ No newline at end of file diff --git a/470/patient_clinical_data.json b/470/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c6afa08ba950f090d881677b798bfaf41707a119 --- /dev/null +++ b/470/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/470/patient_pathological_data.json b/470/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6e23df4e6751c47fc5299e39129e645f8977a9e7 --- /dev/null +++ b/470/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "470", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/470/surgery_description.txt b/470/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3135832307639879540ee2341c59f2362dde1cd2 --- /dev/null +++ b/470/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Neck dissection, PEG placement, Flap coverage (Radial) diff --git a/470/surgery_report.txt b/470/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4c5fd9b29f7771706e93bb297b3e276087f78168 --- /dev/null +++ b/470/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and preparation of the patient by the anesthesia colleagues, a pharyngoscopy is first performed to determine the current extent of the tumor. As described above, the tumor was found to be a superficial exophytic process in the area of the upper right tonsil lobe, beginning to grow uvularly. The base of the uvula is clearly infiltrating and also growing over the left posterior palatal arch towards the left tonsil. In addition, there are wide, island-like suspicious findings distributed over the soft palate, some of which could already be confirmed as invasive carcinoma in the panendoscopy, partly leukoplakic, partly exophytic mucosal changes, which are primarily located at the mucosal level. First of all, the PEG was inserted. For this purpose, insertion with the gastroscope under laryngoscopic control. Easy to see through to the stomach. If diaphanoscopy is good, the stomach can be punctured and the PEG tube inserted using the usual suture pull-through method. The patient is then prepared for definitive resection. Transenorally, first turn to tumor resection. Cutting around the tumor process with the electric needle, later using the dissection technique. The right tonsil is resected in the sense of a radical tonsillectomy. The resection reveals suspicious changes at the mucosal level, including large areas of the posterior palatal arch, which is therefore completely resected up to the posterior pharyngeal wall. Subtotal resection of the soft palate, here partly nodular changes in the area of the mucosa, but no dorsal wall penetration. Tonsillectomy is performed here due to the growth just before the left tonsil. In addition, the tumor is removed and resected en bloc to the extent described. The tumor is now completely imaged at the mucosal level with marginal samples, which are diagnosed in the frozen section diagnostics as completely free of tumor and dysplasia with a clear R0 situation. The graft is now measured with configuration for almost complete replacement of the soft palate and tonsil lobe. The neck dissection and elevation of the radialis graft are now performed in staggered fashion. First turn to the neck dissection of the left side. Here the skin incision is made at the anterior edge of the sternocleidomastoid muscle, curved. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma, exposure of the sternocleidomastoid muscle, omohyoid muscle and gastric muscle after exposure of the submandibular gland. Dissection of the anterior neck preparation with exposure and protection of the cervical artery, the superior thyroid artery, the facial vein and the hypoglossal nerve. Dissection of the internal jugular vein, visualization of the accessorius nerve. Numerous nodules of somewhat conspicuous size can be seen in the course of the vein, but without infiltrative growth. Clearing of the accessorius triangle with careful protection of the nerve. Subsequent evacuation of level V with careful protection of the cervical plexus branches. Caudal check for lymphatic dryness. Careful inspection and palpation of all wound cavities and surfaces, followed by wound irrigation and insertion of a 10-gauge Redon drain and careful two-layer wound closure. Then turn to the opposite side. The procedure is basically the same here. Curved skin incision on the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and transection of the platyma. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digasatric muscle. Release of the anterior neck preparation with careful protection of the superior thyroid artery, the cervical sinus, the hypoglossal nerve and the facial vein in the region of the neck. Exposure of the accessorius nerve. Clearing of the accessorius triangle with careful protection of the nerve. Subsequent evacuation of level V with careful protection of the cervical plexus branches. Here too, in the area of the vein course, several nodules, somewhat conspicuous in number and size, without definite malignancy criteria. This is followed by transection and resection of the venter anterior digastric muscle, exposure of the styloid and performance of the pharyngotomy, partial resection and opening of the musculature and creation of a sufficient tunnel for displacement of the pedicle. Now to lift the radialis graft. The patient had a chainsaw injury with reconstruction of the hand, but the radial artery had already been correctly positioned preoperatively. No scarring along the course here either. Marking of the graft in a special configuration. Performing the graft elevation in bloodlessness. Incision of the graft. Exposure of the cephalic vein. Perform the Haydn maneuver to identify the superficial ramus, radial nerve, which must be partially removed in the area of a transverse hand arch. The main trunk can be preserved. Identification of the distal vascular pedicle. Separation after ligation. Ulnar dissection with exposure of the flexor carpi ulnaris. Strict superfacial release of the graft. Dissection of the pedicle including the cephalic vein. Exposure of the radial artery, very high exit of the ulnar artery. Exposure of the common interosseous artery, which is spared. Exposure of the venous bridge to the........ system. Therefore, use the cephalic vein for subsequent anastomosis. Reopening of the vena cava. Regular and complete hand perfusion and excellent graft perfusion are immediately apparent. After careful hemostasis, placement of the graft, later careful two-layer wound closure with incorporation of the full-thickness skin lifted from the right groin. Subsequent application of the vacuum pump and placement of the Cramer splint in the functional site with subsequent repositioning of the arm. Full-thickness skin removal from the right groin. To do this, cut around a piece of skin measuring approx. 12 x 5 cm, strictly cutaneous lifting. Subcutaneous mobilization afterwards. Insertion of a 10-gauge Redon drain and, if the wound was dry, strong and multi-layered wound closure. The graft was incorporated at the same time. Good fit with intact conditions on all sides. Pedicle positioning and conditioning. Conditioning of the superior thyroid artery and facial artery. Performing the arterial anastomosis with 8.0 Ethilon, this is considerably more difficult due to the caliber and difference, but is ultimately successful with immediate regular venous return. Measuring a size 3.5 coupler and performing a venous anastomosis with the coupler. Subsequently, regular perfusion and pulsation with excellent enoral flap perfusion. Postoperatively, please abstain from food for 7 days, then gradually build up the diet. Intraoperative R0 resected cT3 oral cavity carcinoma. Extension of adjuvant therapy depending on lymph node status. \ No newline at end of file diff --git a/471/InvasionFront_CD3_block6_x3_y11_patient471_0.json b/471/InvasionFront_CD3_block6_x3_y11_patient471_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8911abb5a4126d38194911ebf236f6a372896724 --- /dev/null +++ b/471/InvasionFront_CD3_block6_x3_y11_patient471_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 28559.9, + "Num Detections": 16640, + "Num Negative": 15835, + "Num Positive": 805, + "Positive %": 4.838, + "Num Positive per mm^2": 399.02 + } +} \ No newline at end of file diff --git a/471/InvasionFront_CD3_block6_x4_y11_patient471_1.json b/471/InvasionFront_CD3_block6_x4_y11_patient471_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f7fe3f164131e6f0456301fee693e1ee3d7588e0 --- /dev/null +++ b/471/InvasionFront_CD3_block6_x4_y11_patient471_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13777.0, + "Centroid Y µm": 28796.8, + "Num Detections": 21195, + "Num Negative": 20819, + "Num Positive": 376, + "Positive %": 1.774, + "Num Positive per mm^2": 161.68 + } +} \ No newline at end of file diff --git a/471/InvasionFront_CD8_block6_x3_y9_patient471_0.json b/471/InvasionFront_CD8_block6_x3_y9_patient471_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b9c3ccb4625cef1be11086049bd92bc21f770f79 --- /dev/null +++ b/471/InvasionFront_CD8_block6_x3_y9_patient471_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11768.8, + "Centroid Y µm": 22688.0, + "Num Detections": 16228, + "Num Negative": 12732, + "Num Positive": 3496, + "Positive %": 21.54, + "Num Positive per mm^2": 1766.4 + } +} \ No newline at end of file diff --git a/471/InvasionFront_CD8_block6_x4_y9_patient471_1.json b/471/InvasionFront_CD8_block6_x4_y9_patient471_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7c8888388fd04f2ba20a756bdae6bbf40ef2034b --- /dev/null +++ b/471/InvasionFront_CD8_block6_x4_y9_patient471_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 22887.9, + "Num Detections": 14166, + "Num Negative": 9633, + "Num Positive": 4533, + "Positive %": 32.0, + "Num Positive per mm^2": 2271.5 + } +} \ No newline at end of file diff --git a/471/TumorCenter_CD3_block6_x3_y9_patient471_0.json b/471/TumorCenter_CD3_block6_x3_y9_patient471_0.json new file mode 100644 index 0000000000000000000000000000000000000000..523d41499cc250f2b26bed0120e043bdeb31c265 --- /dev/null +++ b/471/TumorCenter_CD3_block6_x3_y9_patient471_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11319.0, + "Centroid Y µm": 23162.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/471/TumorCenter_CD3_block6_x4_y9_patient471_1.json b/471/TumorCenter_CD3_block6_x4_y9_patient471_1.json new file mode 100644 index 0000000000000000000000000000000000000000..93e5c95caa8ff6cf04b75282159102f2cda0ad53 --- /dev/null +++ b/471/TumorCenter_CD3_block6_x4_y9_patient471_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 23137.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/471/TumorCenter_CD8_block6_x3_y9_patient471_0.json b/471/TumorCenter_CD8_block6_x3_y9_patient471_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f66891075e7d888b99212415b61f129232c16b0 --- /dev/null +++ b/471/TumorCenter_CD8_block6_x3_y9_patient471_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 23287.7, + "Num Detections": 14014, + "Num Negative": 11446, + "Num Positive": 2568, + "Positive %": 18.32, + "Num Positive per mm^2": 1517.8 + } +} \ No newline at end of file diff --git a/471/TumorCenter_CD8_block6_x4_y9_patient471_1.json b/471/TumorCenter_CD8_block6_x4_y9_patient471_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3da92157fa8f0eac09e73cd75d8834300f545601 --- /dev/null +++ b/471/TumorCenter_CD8_block6_x4_y9_patient471_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 23237.7, + "Num Detections": 18358, + "Num Negative": 16104, + "Num Positive": 2254, + "Positive %": 12.28, + "Num Positive per mm^2": 1148.7 + } +} \ No newline at end of file diff --git a/471/history_text.txt b/471/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1f1ee491ddb3ac68066b68f91fd0cbf3f3b819e7 --- /dev/null +++ b/471/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma postcricoid, therefore surgery indicated. \ No newline at end of file diff --git a/471/icd_codes.txt b/471/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..43933df3f1c9d6532e2ca0f17c971d07351ae1c3 --- /dev/null +++ b/471/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hinterwand des Hypopharynx[C13.2 ] \ No newline at end of file diff --git a/471/ops_codes.txt b/471/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6186f3ae1d02454de4aa599a5de8a9cb29d92a75 --- /dev/null +++ b/471/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Einfache Laryngektomie mit Rekonstruktion mit gestieltem regionalen Lappen[5-303.02 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Entnahme eines gestielten Fernlappens an der Haut und Unterhaut der Brustwand und des Rückens zur Lappenplastik[5-904.2a ] Einlegen einer Stimmprothese[5-319.9 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/471/patient_clinical_data.json b/471/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..49b87897fe276b9fc903bd5d076ab70d50c19753 --- /dev/null +++ b/471/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 77, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/471/patient_pathological_data.json b/471/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..693ae54f9ed40759e7671e1fa60674f9acb2e556 --- /dev/null +++ b/471/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "471", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 57, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/471/surgery_description.txt b/471/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4dbd3bfdf7bd7aed6573c3a536c670cad0ef108e --- /dev/null +++ b/471/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Right-sided neck dissection, Defect coverage, Pedicled flap (Pectoralis major), Provox prosthesis diff --git a/471/surgery_report.txt b/471/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0bfddcc000f11ac9f5b1125d4c389165fabb705 --- /dev/null +++ b/471/surgery_report.txt @@ -0,0 +1 @@ +After anesthesiological preparation, the patient is again positioned and pharyngoscopy and laryngoscopy are performed. The large tumor is seen in the area of the postcricoidal section extending to the border of the esophageal entrance, but not infiltrating it. Due to the location and size of the tumor, laser resection does not make sense for functional reasons, as the indication for laryngectomy is now confirmed. Due to the location, it may also be necessary to cover the defect with a flap, especially in the direction of the esophageal entrance. Therefore, these regions are now also covered. First inject 10 ml of Ultracaine 1% with adrenaline into each side of the neck and cover sterilely. Subsequently apron flap in the typical manner. Neck dissection on the left: A large cranial lymph node conglomerate is seen. Radical neck dissection is necessary to remove this. Resection of the cranial and inferior sternocleidomastoid muscle and removal of the digastric muscle follows. The hypoglossal nerve moves into the tumor and cannot be preserved, nor can the accessorius nerve. The internal jugular vein is double ligated cranially and caudally. The common carotid artery is also dissected from the lymph node conglomerate cranially and medially. Relatively firm adherence here. However, it is possible to dissect the tumor macroscopically in healthy tissue. A marginal sample is taken from the area of the common carotid artery and internal carotid artery on the carotid artery wall and sent for frozen section. No clear tumor infiltrates in the frozen section. The vagus nerve and border cord can be preserved. Level II to V excision follows, partly including the cervical plexus. As part of the evacuation of the anterior neck, the facial nerve also had to be ligated. Neck dissection on the right by , PJ: After creation of the apron flap, exposure of the omohyoid muscle, exposure of the submandibular gland, the accessory nerve, anterior border of the sternocleidomastoid muscle, posterior belly of the digaster, cervical vascular sheath. The anterior neck preparation is first performed and completely detached from the omohyoid and cervical vascular sheath, below the submandibular gland. This is then skeletonized and the posterior venter of the digaster muscle is traced. The cervical vascular sheath is now dissected from below so that the neck preparation can be folded laterally from II to V. Macroscopically clear metastases are removed. The facial vein is cut and ligated. Now the neck preparation is successively detached from level II b to V b after all borders have been exposed. The accessory nerve and the cervical plexus are preserved. Removal of the neck preparation without a chyle fistula. Punctual hemostasis. Slightly larger venous and arterial branches are treated by ligation. The ACE, ACI, ACC, internal jugular vein remain intact. Also the vagus and hypoglossal nerves. At this point, the operation is handed over to to perform the layngectomy, placement of the Provox prosthesis and tracheostomy. Subsequent laryngectomy: First isolate hyoid bone. pre-epiglottic fatty tissue is retracted into the tumor preparation. Infrahyoid muscles are dissected caudally from the hyoid bone and cut caudolaterally. The superior chorda is isolated on both sides, the constrictor muscle is separated on both sides. Further dissection on the inner side of the thyroid cartilage on both sides. The thyroid lobe is dissected off caudolaterally on both sides. The isthmus is severed and treated with stitches. A tracheotomy is then created. Re-intubation. Now enter cranially at the level of the epiglottis. Incision of the epiglottis of the arytenoid fold. Incision of the tumor in the postcricoid area with a distance of at least 1-1 1/2 cm on all sides. Subsequent removal of the larynx at the trachea directly subglottically. Take a marginal sample from the caudal area towards the esophageal entrance. Diesel suture-marked for frozen section together with the entire tumor specimen. Cranial tumor infiltrates are still questionable in the frozen section, therefore a 1 cm wide resection is performed in the transition to the cranial epiglottis at the base of the tongue as well as a marginal sample, which is now tumor-free. Thus R0 situation in the area of the pharyngeal tube. Now myotomy on the left side up to the last fiber. Insertion of an 8 mm Provox prosthesis in the typical manner. Then decision to elevate a pectoralis major flap as the esophageal entrance would become too narrow after suturing and the swallowing function would no longer be intact. Therefore, the dimensions of the pectoralis major flap were measured. Length 8 cm, maximum width 6 cm. Marking on the chest wall. Axillary skin incision. Creation of a tunnel in the area below the deltopectoral flap facially. The tunnel is created up to the lower borders of the neck wound. Subsequent incision of the skin island and the underlying muscle. Repeated application of several shear sutures. Finally, develop the flap along the course of the pedicle up to the clavicle, always keeping it under control. Push the flap through. Successive suturing of the skin flap into the defect with 3-0 Vicryl single button sutures completely tension-free after loosening the anti-shear sutures. Musculature is stitched over it in a further row of sutures. This is done in particular towards the base of the tongue and laterally. Followed by careful irrigation. Hemostasis. Layered wound closure of the neck wounds with insertion of Redon drains and the thoracic wound also with insertion of 2 Redon drains. Epithelialization of the tracheostoma here too. Insertion of a 9 mm tracheostomy tube. A nasogastric tube was also inserted during the procedure. The procedure was completed without complications. Patient admitted to intensive care unit for monitoring. Postoperative continuation of the intraoperatively administered antibiotics with Unacid. Feeding via gastric tube for 10-12 days, then gruel and, if necessary, diet build-up. Wait for the final histology, especially in the area of the extensive tissue removal in the area of the common carotid artery. Overall presentation at the interdisciplinary tumor conference. In N3b status, radiochemotherapy should be given in all cases. \ No newline at end of file diff --git a/472/InvasionFront_CD3_block16_x1_y9_patient472_0.json b/472/InvasionFront_CD3_block16_x1_y9_patient472_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3413e9dbb00815ae5501dd5534480aa135397b9e --- /dev/null +++ b/472/InvasionFront_CD3_block16_x1_y9_patient472_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4454.5, + "Centroid Y µm": 26746.5, + "Num Detections": 16540, + "Num Negative": 14758, + "Num Positive": 1782, + "Positive %": 10.77, + "Num Positive per mm^2": 870.75 + } +} \ No newline at end of file diff --git a/472/InvasionFront_CD3_block16_x2_y9_patient472_1.json b/472/InvasionFront_CD3_block16_x2_y9_patient472_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e58a9ba8e5dc06fb9846ab9b364d663ba3327b63 --- /dev/null +++ b/472/InvasionFront_CD3_block16_x2_y9_patient472_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7015.6, + "Centroid Y µm": 26975.5, + "Num Detections": 16509, + "Num Negative": 14281, + "Num Positive": 2228, + "Positive %": 13.5, + "Num Positive per mm^2": 1054.9 + } +} \ No newline at end of file diff --git a/472/InvasionFront_CD8_block16_x1_y9_patient472_0.json b/472/InvasionFront_CD8_block16_x1_y9_patient472_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e8eea3ac5ed87b50abdd42d0e2a94497c0c4a244 --- /dev/null +++ b/472/InvasionFront_CD8_block16_x1_y9_patient472_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3322.4, + "Centroid Y µm": 21862.3, + "Num Detections": 15236, + "Num Negative": 13288, + "Num Positive": 1948, + "Positive %": 12.79, + "Num Positive per mm^2": 982.77 + } +} \ No newline at end of file diff --git a/472/InvasionFront_CD8_block16_x2_y9_patient472_1.json b/472/InvasionFront_CD8_block16_x2_y9_patient472_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4f9643136a6fd6a37bf4236697f0cb5ab4001a2f --- /dev/null +++ b/472/InvasionFront_CD8_block16_x2_y9_patient472_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5968.5, + "Centroid Y µm": 21892.6, + "Num Detections": 12681, + "Num Negative": 10761, + "Num Positive": 1920, + "Positive %": 15.14, + "Num Positive per mm^2": 949.46 + } +} \ No newline at end of file diff --git a/472/TumorCenter_CD3_block16_x1_y9_patient472_0.json b/472/TumorCenter_CD3_block16_x1_y9_patient472_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f87e1bcf9c182a81bba7b6eb77e0aff433e7f8d --- /dev/null +++ b/472/TumorCenter_CD3_block16_x1_y9_patient472_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3848.0, + "Centroid Y µm": 22588.0, + "Num Detections": 13975, + "Num Negative": 11565, + "Num Positive": 2410, + "Positive %": 17.25, + "Num Positive per mm^2": 1149.1 + } +} \ No newline at end of file diff --git a/472/TumorCenter_CD3_block16_x2_y9_patient472_1.json b/472/TumorCenter_CD3_block16_x2_y9_patient472_1.json new file mode 100644 index 0000000000000000000000000000000000000000..04f697117da1b2fc5bfb4638471d30d853989717 --- /dev/null +++ b/472/TumorCenter_CD3_block16_x2_y9_patient472_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 22738.0, + "Num Detections": 14629, + "Num Negative": 13364, + "Num Positive": 1265, + "Positive %": 8.647, + "Num Positive per mm^2": 608.68 + } +} \ No newline at end of file diff --git a/472/TumorCenter_CD8_block16_x1_y9_patient472_0.json b/472/TumorCenter_CD8_block16_x1_y9_patient472_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f17239005764e321a9c0f363f611809f160440d --- /dev/null +++ b/472/TumorCenter_CD8_block16_x1_y9_patient472_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3573.1, + "Centroid Y µm": 22837.9, + "Num Detections": 14275, + "Num Negative": 12582, + "Num Positive": 1693, + "Positive %": 11.86, + "Num Positive per mm^2": 807.2 + } +} \ No newline at end of file diff --git a/472/TumorCenter_CD8_block16_x2_y9_patient472_1.json b/472/TumorCenter_CD8_block16_x2_y9_patient472_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b1335a23f250c0c71984f047c30c6cd8c95f2055 --- /dev/null +++ b/472/TumorCenter_CD8_block16_x2_y9_patient472_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 22887.9, + "Num Detections": 16136, + "Num Negative": 15362, + "Num Positive": 774, + "Positive %": 4.797, + "Num Positive per mm^2": 378.87 + } +} \ No newline at end of file diff --git a/472/history_text.txt b/472/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0f124090e49af303bbc1190bf743eaf060b12260 --- /dev/null +++ b/472/history_text.txt @@ -0,0 +1 @@ +Mrs. has a histologically confirmed, moderately differentiated carcinoma of the underside of the left tongue, transition to the left floor of the mouth. Therefore, the above-mentioned operation is now indicated. \ No newline at end of file diff --git a/472/icd_codes.txt b/472/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b471b784d2b9d9c09a5a3b27210fcf133740a8a5 --- /dev/null +++ b/472/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 ] \ No newline at end of file diff --git a/472/ops_codes.txt b/472/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10410c5c5fa2c10eb86c301fc7cbba3d7d7d55e8 --- /dev/null +++ b/472/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Pharyngoskopie: Indirekt[1-611.1 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Destruktion: Elektrokoagulation[5-250.30 ] Partielle Glossektomie: Transoral: Sonstige[5-251.0x ] Drainage Speicheldrüse und Speicheldrüsenausführungsgang Ausführungsgang[5-260.11 L] \ No newline at end of file diff --git a/472/patient_clinical_data.json b/472/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..582eef03e423f43dc66b1332ac24e71666c863b6 --- /dev/null +++ b/472/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 47, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy + brachytherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/472/patient_pathological_data.json b/472/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..95b9765de7841581c6df3feae8fb07aab82004e5 --- /dev/null +++ b/472/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "472", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/472/surgery_description.txt b/472/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ab6802cce3ba6d869b2571e7fced1445d1df0d69 --- /dev/null +++ b/472/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy, Panendoscopy diff --git a/472/surgery_report.txt b/472/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..de8e0bb7cbae16d8b152d56a2e87f5523c72cd33 --- /dev/null +++ b/472/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia, tracheoscopy is first performed with the 0° scope: this reveals inconspicuous mucosal conditions subglottically up to the carina. Now orotracheal intubation by the surgeon. First flexible esophagogastroscopy: Here the mucosal conditions are unremarkable on all sides. Now proceed to pharyngoscopy/laryngoscopy: Apart from the following findings, there are no further abnormalities in the entire oropharynx, hypopharynx and larynx region, in particular the tonsil lobe, base of tongue, vallecula, piriform sinus on both sides, esophageal entrance, postcricoid region and in the endolarynx. Now insertion of the mouth retractor and inspection of the oral cavity: An approx. 1.5 cm large, partially exulcerated mass is seen, which is located laterally on the underside of the tongue and extends to the lateral floor of the mouth. The mass is approx. 1 cm away from the left Wharton's duct. The entire mass is now incised with a safety margin of approx. 1 cm. Care is taken to maintain a sufficient distance in the area of the tongue muscles and in the caudal lateral area the resection extends to the Wharton's duct. The latter is injured and must then be marsupialized. Part of the sublingual gland is also resected posteriorly. The tumor specimen is now completely excised and sent for frozen section diagnostics with suture marking and diagnosed as R0. Careful hemostasis. Marsupialization of the Wharton's duct with 5.0 Monocryl sutures. Placement of a TachoSil swab on the muscle fiber to prevent secondary bleeding. Completion of the procedure without bleeding or complications. The patient should be presented at our tumor conference to decide whether to perform a neck dissection and/or adjuvant therapy. \ No newline at end of file diff --git a/473/InvasionFront_CD3_block19_x5_y5_patient473_0.json b/473/InvasionFront_CD3_block19_x5_y5_patient473_0.json new file mode 100644 index 0000000000000000000000000000000000000000..232fecd34cfcf3f8a4272d30eb0e4f524b7a15e3 --- /dev/null +++ b/473/InvasionFront_CD3_block19_x5_y5_patient473_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17140.9, + "Centroid Y µm": 15192.0, + "Num Detections": 17662, + "Num Negative": 16995, + "Num Positive": 667, + "Positive %": 3.776, + "Num Positive per mm^2": 308.03 + } +} \ No newline at end of file diff --git a/473/InvasionFront_CD3_block19_x6_y5_patient473_1.json b/473/InvasionFront_CD3_block19_x6_y5_patient473_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1d3e6d22ec84e6172cf417381a2e88b4048bf18b --- /dev/null +++ b/473/InvasionFront_CD3_block19_x6_y5_patient473_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19664.6, + "Centroid Y µm": 15416.8, + "Num Detections": 18238, + "Num Negative": 17330, + "Num Positive": 908, + "Positive %": 4.979, + "Num Positive per mm^2": 414.04 + } +} \ No newline at end of file diff --git a/473/InvasionFront_CD8_block19_x5_y5_patient473_0.json b/473/InvasionFront_CD8_block19_x5_y5_patient473_0.json new file mode 100644 index 0000000000000000000000000000000000000000..991d95a600a945879adef1e8ce83d0910d2842ad --- /dev/null +++ b/473/InvasionFront_CD8_block19_x5_y5_patient473_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 22663.0, + "Num Detections": 17530, + "Num Negative": 17304, + "Num Positive": 226, + "Positive %": 1.289, + "Num Positive per mm^2": 96.54 + } +} \ No newline at end of file diff --git a/473/InvasionFront_CD8_block19_x6_y5_patient473_1.json b/473/InvasionFront_CD8_block19_x6_y5_patient473_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b0e98cbdecc6bf2ae4d5e5c846a8b7ce545d63c8 --- /dev/null +++ b/473/InvasionFront_CD8_block19_x6_y5_patient473_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19364.7, + "Centroid Y µm": 22688.0, + "Num Detections": 23181, + "Num Negative": 22528, + "Num Positive": 653, + "Positive %": 2.817, + "Num Positive per mm^2": 256.8 + } +} \ No newline at end of file diff --git a/473/TumorCenter_CD3_block19_x5_y5_patient473_0.json b/473/TumorCenter_CD3_block19_x5_y5_patient473_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9b71e0ad665819c00b100d4a278d5b72e9151411 --- /dev/null +++ b/473/TumorCenter_CD3_block19_x5_y5_patient473_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16691.2, + "Centroid Y µm": 12993.1, + "Num Detections": 17498, + "Num Negative": 17261, + "Num Positive": 237, + "Positive %": 1.354, + "Num Positive per mm^2": 110.05 + } +} \ No newline at end of file diff --git a/473/TumorCenter_CD3_block19_x6_y5_patient473_1.json b/473/TumorCenter_CD3_block19_x6_y5_patient473_1.json new file mode 100644 index 0000000000000000000000000000000000000000..10d9fed56336ab85c80d90a078e479372377c7ef --- /dev/null +++ b/473/TumorCenter_CD3_block19_x6_y5_patient473_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19264.8, + "Centroid Y µm": 12593.3, + "Num Detections": 17257, + "Num Negative": 17144, + "Num Positive": 113, + "Positive %": 0.6548, + "Num Positive per mm^2": 47.01 + } +} \ No newline at end of file diff --git a/473/TumorCenter_CD8_block19_x5_y5_patient473_0.json b/473/TumorCenter_CD8_block19_x5_y5_patient473_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5fca151f69f454f6383e8ac83dd0ca16e8d5853a --- /dev/null +++ b/473/TumorCenter_CD8_block19_x5_y5_patient473_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 23487.6, + "Num Detections": 18165, + "Num Negative": 17868, + "Num Positive": 297, + "Positive %": 1.635, + "Num Positive per mm^2": 130.6 + } +} \ No newline at end of file diff --git a/473/TumorCenter_CD8_block19_x6_y5_patient473_1.json b/473/TumorCenter_CD8_block19_x6_y5_patient473_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bcfc1ce38c8116fb8a66890ae3f3232967c31c5c --- /dev/null +++ b/473/TumorCenter_CD8_block19_x6_y5_patient473_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21488.6, + "Centroid Y µm": 23387.6, + "Num Detections": 18193, + "Num Negative": 18097, + "Num Positive": 96, + "Positive %": 0.5277, + "Num Positive per mm^2": 39.36 + } +} \ No newline at end of file diff --git a/473/history_text.txt b/473/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/473/icd_codes.txt b/473/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b2b94cb50933cfa2488a2941aa728866a25f7e3 --- /dev/null +++ b/473/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 ] \ No newline at end of file diff --git a/473/ops_codes.txt b/473/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4a3953f699e9ebb1e4ab0f06bae3dfb58a56ab60 --- /dev/null +++ b/473/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Endoskopische Laserresektion am Larynx[5-302.5 ] \ No newline at end of file diff --git a/473/patient_clinical_data.json b/473/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6b971f30e07a28f3f9864f6d5bb08fd7c16ec1b3 --- /dev/null +++ b/473/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 77, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 50, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/473/patient_pathological_data.json b/473/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9dc2896de3a9017b123d08be82f660f21964c974 --- /dev/null +++ b/473/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "473", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/473/surgery_description.txt b/473/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b45ea1174e5848dbc7e53358c76517376cec36f6 --- /dev/null +++ b/473/surgery_description.txt @@ -0,0 +1 @@ +Laser resection diff --git a/473/surgery_report.txt b/473/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d69226ffbf63634eea70f66efc5f44e6d5e5e5f8 --- /dev/null +++ b/473/surgery_report.txt @@ -0,0 +1 @@ +After an introductory consultation with the anesthesia colleagues, the patient is first positioned and the supraglottis is adjusted on the left side using the size B small bore tube. Beforehand, complete mirroring of the oral cavity, oropharynx, hypopharynx and larynx. There is no evidence of a further mass. The tumor of the supraglottis on the left side is narrow-based and stemmed laterodorsal to the arytenoid hump and extends from here to the anterior wall of the piriform sinus. The tumor can now be easily cut around at its base with a safety margin of about 3-4 mm. The tumor shows an extremely shallow penetration depth and can be resected superficially here. Complete resection of the tumor is achieved using microsurgical techniques and resection with the CO2 laser. Representative marginal samples are then taken from the area of the basal metastasis and all metastatic margins. These are sent intraoperatively for frozen section diagnostics. All of these marginal samples are found to be tumor-free in the frozen section intraoperatively, so that the procedure can be completed after a final consultation with the anesthesiology colleagues and removal of all instruments after the final wound check and absence of bleeding. \ No newline at end of file diff --git a/474/InvasionFront_CD3_block20_x5_y4_patient474_0.json b/474/InvasionFront_CD3_block20_x5_y4_patient474_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2fefdd0b41c9539bc199bf008240ee61fa949a73 --- /dev/null +++ b/474/InvasionFront_CD3_block20_x5_y4_patient474_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17740.6, + "Centroid Y µm": 10294.5, + "Num Detections": 21390, + "Num Negative": 20084, + "Num Positive": 1306, + "Positive %": 6.106, + "Num Positive per mm^2": 495.96 + } +} \ No newline at end of file diff --git a/474/InvasionFront_CD3_block20_x6_y4_patient474_1.json b/474/InvasionFront_CD3_block20_x6_y4_patient474_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ac7fc9c4eafaa8059e5605c1638d689b6eb7dad8 --- /dev/null +++ b/474/InvasionFront_CD3_block20_x6_y4_patient474_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20339.2, + "Centroid Y µm": 10544.4, + "Num Detections": 19755, + "Num Negative": 19038, + "Num Positive": 717, + "Positive %": 3.629, + "Num Positive per mm^2": 307.27 + } +} \ No newline at end of file diff --git a/474/InvasionFront_CD8_block20_x5_y4_patient474_0.json b/474/InvasionFront_CD8_block20_x5_y4_patient474_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3677c97f75305ea4cced4d7b0583cdf3b0a08884 --- /dev/null +++ b/474/InvasionFront_CD8_block20_x5_y4_patient474_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 9944.7, + "Num Detections": 22029, + "Num Negative": 21606, + "Num Positive": 423, + "Positive %": 1.92, + "Num Positive per mm^2": 163.61 + } +} \ No newline at end of file diff --git a/474/InvasionFront_CD8_block20_x6_y4_patient474_1.json b/474/InvasionFront_CD8_block20_x6_y4_patient474_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e70bcc5fd7b23be3e376391cbc30754297c52375 --- /dev/null +++ b/474/InvasionFront_CD8_block20_x6_y4_patient474_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19164.9, + "Centroid Y µm": 9819.8, + "Num Detections": 21446, + "Num Negative": 21209, + "Num Positive": 237, + "Positive %": 1.105, + "Num Positive per mm^2": 91.95 + } +} \ No newline at end of file diff --git a/474/TumorCenter_CD3_block20_x5_y4_patient474_0.json b/474/TumorCenter_CD3_block20_x5_y4_patient474_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b7a903f41410e5918d02f970bc6448041a5f6727 --- /dev/null +++ b/474/TumorCenter_CD3_block20_x5_y4_patient474_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16387.8, + "Centroid Y µm": 9385.0, + "Num Detections": 18122, + "Num Negative": 17503, + "Num Positive": 619, + "Positive %": 3.416, + "Num Positive per mm^2": 270.06 + } +} \ No newline at end of file diff --git a/474/TumorCenter_CD3_block20_x6_y4_patient474_1.json b/474/TumorCenter_CD3_block20_x6_y4_patient474_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fda7868e07424646fd29ceac34a7813570e5eed4 --- /dev/null +++ b/474/TumorCenter_CD3_block20_x6_y4_patient474_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18939.3, + "Centroid Y µm": 9353.8, + "Num Detections": 14706, + "Num Negative": 14138, + "Num Positive": 568, + "Positive %": 3.862, + "Num Positive per mm^2": 298.78 + } +} \ No newline at end of file diff --git a/474/TumorCenter_CD8_block20_x5_y4_patient474_0.json b/474/TumorCenter_CD8_block20_x5_y4_patient474_0.json new file mode 100644 index 0000000000000000000000000000000000000000..86760a3339298f2cdaf1559d8840377bd750816d --- /dev/null +++ b/474/TumorCenter_CD8_block20_x5_y4_patient474_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15616.7, + "Centroid Y µm": 9669.9, + "Num Detections": 21982, + "Num Negative": 21586, + "Num Positive": 396, + "Positive %": 1.801, + "Num Positive per mm^2": 156.09 + } +} \ No newline at end of file diff --git a/474/TumorCenter_CD8_block20_x6_y4_patient474_1.json b/474/TumorCenter_CD8_block20_x6_y4_patient474_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ac01dc2aed9329b142f4a16491a255a59107eaad --- /dev/null +++ b/474/TumorCenter_CD8_block20_x6_y4_patient474_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18065.4, + "Centroid Y µm": 9445.0, + "Num Detections": 19660, + "Num Negative": 19207, + "Num Positive": 453, + "Positive %": 2.304, + "Num Positive per mm^2": 191.4 + } +} \ No newline at end of file diff --git a/474/history_text.txt b/474/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8602702f739ce2f799d966d8d28adfc04f9725d4 --- /dev/null +++ b/474/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: mass in the area of the right glottis, extending from the posterior third of the vocal folds to just below the anterior commissure. Extremely difficult to adjust. Histologically confirmed as squamous cell carcinoma. \ No newline at end of file diff --git a/474/icd_codes.txt b/474/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3fc441e4d4825c4aa1cb2d74ab85b413db0db51b --- /dev/null +++ b/474/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 ] \ No newline at end of file diff --git a/474/ops_codes.txt b/474/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..349cf7c7607ff28a247e8ea84b89b33f4b830233 --- /dev/null +++ b/474/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] \ No newline at end of file diff --git a/474/patient_clinical_data.json b/474/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4cfe4bd53aba997cf207fbd8753e4a3dd9e00dfa --- /dev/null +++ b/474/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 4, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/474/patient_pathological_data.json b/474/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4cf8673b5fbbe77ed770de0d9872e2c3e9d60aa3 --- /dev/null +++ b/474/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "474", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/474/surgery_description.txt b/474/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5462faa1f571443b90f96a41d612b40acfcafecc --- /dev/null +++ b/474/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection diff --git a/474/surgery_report.txt b/474/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e726c6855b33b081090c5ef2bc2f5edfa7a85402 --- /dev/null +++ b/474/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Then adjustment of the larynx with the size C small bore tube. This is extremely difficult. By positioning the patient appropriately, the glottic plane can be adjusted well. Using the laser, resection of the tumor in the sense of a right chordectomy. The resection ultimately extends from the posterior commissure from the tip of the arytenoid cartilage to the anterior commissure. Careful preparation in the paraglottic space. Repositioning the MLE tube and changing the MLE tube so that the anterior commissure can be exposed with the smallest MLE tube (size D). Clinically, it is clearly possible to cut around the tumor in healthy tissue, whereby large parts of the subglottic slope and the vocalis muscle are also resected. In the area of the anterior commissure, the cartilage is exposed in a circumscribed manner. As far as can be assessed intraoperatively, the tumor can be completely resected in the healthy tissue. This is made possible by frequent changes of position and massive external pressure. After resection of the tumor, a total of four marginal samples are taken, all of which are found to be tumor-free in the frozen section. Careful hemostasis. Completion of the procedure. In view of the size of the tumor, a control MLE is absolutely indicated in 6-8 weeks. Final consultation with the anesthesiologist. Transfer of the patient to the recovery ward. \ No newline at end of file diff --git a/475/InvasionFront_CD3_block21_x5_y9_patient475_0.json b/475/InvasionFront_CD3_block21_x5_y9_patient475_0.json new file mode 100644 index 0000000000000000000000000000000000000000..02621aad7ee76cee6e7cb4e63ca492108f2b8d5c --- /dev/null +++ b/475/InvasionFront_CD3_block21_x5_y9_patient475_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18365.3, + "Centroid Y µm": 33282.4, + "Num Detections": 3664, + "Num Negative": 2626, + "Num Positive": 1038, + "Positive %": 28.33, + "Num Positive per mm^2": 2273.5 + } +} \ No newline at end of file diff --git a/475/InvasionFront_CD3_block21_x6_y9_patient475_1.json b/475/InvasionFront_CD3_block21_x6_y9_patient475_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fb170564ef342223dd9c34169bfa8b77caec0c79 --- /dev/null +++ b/475/InvasionFront_CD3_block21_x6_y9_patient475_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20864.0, + "Centroid Y µm": 33757.1, + "Num Detections": 21765, + "Num Negative": 15596, + "Num Positive": 6169, + "Positive %": 28.34, + "Num Positive per mm^2": 2684.3 + } +} \ No newline at end of file diff --git a/475/InvasionFront_CD8_block21_x5_y9_patient475_0.json b/475/InvasionFront_CD8_block21_x5_y9_patient475_0.json new file mode 100644 index 0000000000000000000000000000000000000000..78f1032d3dac59dc48d6acbfae0c64af837339a5 --- /dev/null +++ b/475/InvasionFront_CD8_block21_x5_y9_patient475_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 22063.3, + "Num Detections": 12414, + "Num Negative": 8299, + "Num Positive": 4115, + "Positive %": 33.15, + "Num Positive per mm^2": 2780.9 + } +} \ No newline at end of file diff --git a/475/InvasionFront_CD8_block21_x6_y9_patient475_1.json b/475/InvasionFront_CD8_block21_x6_y9_patient475_1.json new file mode 100644 index 0000000000000000000000000000000000000000..09f5f7b49d5c3c9c7f5c518e1dda9d11ac76ae75 --- /dev/null +++ b/475/InvasionFront_CD8_block21_x6_y9_patient475_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 22188.3, + "Num Detections": 23420, + "Num Negative": 16185, + "Num Positive": 7235, + "Positive %": 30.89, + "Num Positive per mm^2": 2891.4 + } +} \ No newline at end of file diff --git a/475/TumorCenter_CD3_block21_x5_y9_patient475_0.json b/475/TumorCenter_CD3_block21_x5_y9_patient475_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1467504d2cc88fbdbc42611e0fb72dedd31c046b --- /dev/null +++ b/475/TumorCenter_CD3_block21_x5_y9_patient475_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 25061.7, + "Num Detections": 21326, + "Num Negative": 13274, + "Num Positive": 8052, + "Positive %": 37.76, + "Num Positive per mm^2": 3001.2 + } +} \ No newline at end of file diff --git a/475/TumorCenter_CD3_block21_x6_y9_patient475_1.json b/475/TumorCenter_CD3_block21_x6_y9_patient475_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fb30ed56ec99f028aeef4b77347af61f615e75fc --- /dev/null +++ b/475/TumorCenter_CD3_block21_x6_y9_patient475_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 25086.7, + "Num Detections": 19699, + "Num Negative": 11502, + "Num Positive": 8197, + "Positive %": 41.61, + "Num Positive per mm^2": 3140.1 + } +} \ No newline at end of file diff --git a/475/TumorCenter_CD8_block21_x5_y9_patient475_0.json b/475/TumorCenter_CD8_block21_x5_y9_patient475_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0a5e60924bdd8460427a23d2a6e5c295aec1408c --- /dev/null +++ b/475/TumorCenter_CD8_block21_x5_y9_patient475_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18015.5, + "Centroid Y µm": 37530.1, + "Num Detections": 25422, + "Num Negative": 15838, + "Num Positive": 9584, + "Positive %": 37.7, + "Num Positive per mm^2": 3480.1 + } +} \ No newline at end of file diff --git a/475/TumorCenter_CD8_block21_x6_y9_patient475_1.json b/475/TumorCenter_CD8_block21_x6_y9_patient475_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0f823734ade7deda27870e2209f4a64ac4272f4 --- /dev/null +++ b/475/TumorCenter_CD8_block21_x6_y9_patient475_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20539.1, + "Centroid Y µm": 37630.1, + "Num Detections": 23174, + "Num Negative": 14105, + "Num Positive": 9069, + "Positive %": 39.13, + "Num Positive per mm^2": 3393.9 + } +} \ No newline at end of file diff --git a/475/history_text.txt b/475/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3c716251456802b44c634d560ab1513e41600849 --- /dev/null +++ b/475/history_text.txt @@ -0,0 +1 @@ +The patient had a swelling at the angle of the right jaw approximately 5 weeks ago. This was excised as part of a panendoscopy and lymph node extirpation and sent for histology. This revealed a poorly differentiated squamous cell carcinoma. The patient's history includes a panendoscopy with biopsy of the right tonsil <2010>. The histology at that time showed hyperplastic lymphoepithelial tissue with no evidence of malignancy. Now with confirmed right cervical lymph node metastasis and suspicious findings on one side of the right tonsil, indication for the above-mentioned procedure. \ No newline at end of file diff --git a/475/icd_codes.txt b/475/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5e83105e7bf11f6ca52dbd4665319746d4a9a92e --- /dev/null +++ b/475/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/475/ops_codes.txt b/475/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..75aa8a607e4a08b5dc2824cbe618d12662de1509 --- /dev/null +++ b/475/ops_codes.txt @@ -0,0 +1 @@ +Exzision Tonsillentumor[5-289.x ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Probeexzision sonstige Strukturen Mund und Mundhöhle[1-545.x ] \ No newline at end of file diff --git a/475/patient_clinical_data.json b/475/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a2e1ba067a9697750a1cd5c8e636c0abbed8a592 --- /dev/null +++ b/475/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/475/patient_pathological_data.json b/475/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bf7ca7bdb49dadf87ca7b5f4559c83da490a76c7 --- /dev/null +++ b/475/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "475", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/475/surgery_description.txt b/475/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7e2b060d51137881d6ce9cfd13bc3479c605df71 --- /dev/null +++ b/475/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy on the right with excisional biopsy, Free flap (Radial) diff --git a/475/surgery_report.txt b/475/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..404aca61bd465ed2280e82fc9d5c4fa56964b1c3 --- /dev/null +++ b/475/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Repositioning of the patient and insertion of the mouth guard. The right tonsil is then disluxed with the tonsil grasping forceps and the mucosa is incised over the upper tonsil pole with the conchotomy scissors. Locate the capsule and dissect it in depth. The findings are intraoperatively suspicious for a tumor. Careful bipolar coagulation and removal of the upper tonsil pole with the raspatory and conchotomy scissors. If the findings are suspicious for a tumor, perform a generous resection up to the pharyngeal muscles. Further dissection of the tonsil towards the lower tonsil pole. Generous resection 2 to 3 mm lateral to the resection margin. Bipolar coagulation at the lower tonsil pole and removal of the tonsil. The specimen is thread-marked for urgent histology. At this point, demonstration of the findings to and termination of the procedure in dry conditions. The frozen section diagnosis unfortunately revealed R1, according to the pathology at the upper pole forming a margin, R1 anterolaterally and R0 resected at the lower tonsil pole with a 0.1 cm safety margin. Renewed demonstration of findings to . He recommends no further resection in this session, but a resection with ipsilateral neck dissection with flap coverage if necessary. Conclusion: Tonsillectomy on the right, excision biopsy, which revealed a poorly differentiated squamous cell carcinoma. Unfortunately, no resection in healthy tissue as part of the tonsillectomy. Complete staging and planning of definitive therapy as part of a subsequent resection with or without flap coverage and neck dissection. \ No newline at end of file diff --git a/476/InvasionFront_CD3_block1_x5_y3_patient476_0.json b/476/InvasionFront_CD3_block1_x5_y3_patient476_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1b82f61df1fb28334ed95bb11729bf5b4161cd66 --- /dev/null +++ b/476/InvasionFront_CD3_block1_x5_y3_patient476_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16941.0, + "Centroid Y µm": 9420.0, + "Num Detections": 20153, + "Num Negative": 16539, + "Num Positive": 3614, + "Positive %": 17.93, + "Num Positive per mm^2": 1569.1 + } +} \ No newline at end of file diff --git a/476/InvasionFront_CD3_block1_x6_y3_patient476_1.json b/476/InvasionFront_CD3_block1_x6_y3_patient476_1.json new file mode 100644 index 0000000000000000000000000000000000000000..61b554e28d7127f46b3b3ac91ce62eabf0d59b36 --- /dev/null +++ b/476/InvasionFront_CD3_block1_x6_y3_patient476_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19514.7, + "Centroid Y µm": 9445.0, + "Num Detections": 19978, + "Num Negative": 16200, + "Num Positive": 3778, + "Positive %": 18.91, + "Num Positive per mm^2": 1632.2 + } +} \ No newline at end of file diff --git a/476/InvasionFront_CD8_block1_x5_y3_patient476_0.json b/476/InvasionFront_CD8_block1_x5_y3_patient476_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8c917d05974c46ba618e4beae2b79d0859c27f78 --- /dev/null +++ b/476/InvasionFront_CD8_block1_x5_y3_patient476_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17140.9, + "Centroid Y µm": 8095.7, + "Num Detections": 19003, + "Num Negative": 16499, + "Num Positive": 2504, + "Positive %": 13.18, + "Num Positive per mm^2": 1113.2 + } +} \ No newline at end of file diff --git a/476/InvasionFront_CD8_block1_x6_y3_patient476_1.json b/476/InvasionFront_CD8_block1_x6_y3_patient476_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c9e625260cc0db85b42272a363451ab42cdef3e4 --- /dev/null +++ b/476/InvasionFront_CD8_block1_x6_y3_patient476_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19664.6, + "Centroid Y µm": 8295.6, + "Num Detections": 19595, + "Num Negative": 17755, + "Num Positive": 1840, + "Positive %": 9.39, + "Num Positive per mm^2": 804.62 + } +} \ No newline at end of file diff --git a/476/TumorCenter_CD3_block1_x5_y5_patient476_0.json b/476/TumorCenter_CD3_block1_x5_y5_patient476_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1b12a825b1e08484e7df8227ae2d2e5e9b27ff6a --- /dev/null +++ b/476/TumorCenter_CD3_block1_x5_y5_patient476_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15591.7, + "Centroid Y µm": 12468.4, + "Num Detections": 21440, + "Num Negative": 20072, + "Num Positive": 1368, + "Positive %": 6.381, + "Num Positive per mm^2": 564.43 + } +} \ No newline at end of file diff --git a/476/TumorCenter_CD3_block1_x6_y5_patient476_1.json b/476/TumorCenter_CD3_block1_x6_y5_patient476_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9fb7ad1279cc4c19ef535c840093ce28c3a24306 --- /dev/null +++ b/476/TumorCenter_CD3_block1_x6_y5_patient476_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 12368.5, + "Num Detections": 15600, + "Num Negative": 14991, + "Num Positive": 609, + "Positive %": 3.904, + "Num Positive per mm^2": 296.23 + } +} \ No newline at end of file diff --git a/476/TumorCenter_CD8_block1_x5_y3_patient476_0.json b/476/TumorCenter_CD8_block1_x5_y3_patient476_0.json new file mode 100644 index 0000000000000000000000000000000000000000..69e44f98c39b3d403213858f14852a0421654008 --- /dev/null +++ b/476/TumorCenter_CD8_block1_x5_y3_patient476_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 16241.4, + "Num Detections": 21201, + "Num Negative": 20326, + "Num Positive": 875, + "Positive %": 4.127, + "Num Positive per mm^2": 356.6 + } +} \ No newline at end of file diff --git a/476/TumorCenter_CD8_block1_x6_y3_patient476_1.json b/476/TumorCenter_CD8_block1_x6_y3_patient476_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7fd72846318c9c3fcef15879c3383aa5d578887f --- /dev/null +++ b/476/TumorCenter_CD8_block1_x6_y3_patient476_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21338.7, + "Centroid Y µm": 16166.4, + "Num Detections": 18690, + "Num Negative": 17042, + "Num Positive": 1648, + "Positive %": 8.818, + "Num Positive per mm^2": 715.63 + } +} \ No newline at end of file diff --git a/476/history_text.txt b/476/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fad329fbedbf42814ce7408f2fb12a1ac1146617 --- /dev/null +++ b/476/history_text.txt @@ -0,0 +1 @@ +The patient has had a mass in the left posterior palatal arch for approximately 1 year. The patient also complains of dysphagia and odynophagia. She has also lost more than 5 kg in weight in the last 2-3 months. There is an indication for the above-mentioned operation. \ No newline at end of file diff --git a/476/icd_codes.txt b/476/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a1b44d09c0b3b166d104bede4d1484b2d7869567 --- /dev/null +++ b/476/icd_codes.txt @@ -0,0 +1 @@ +Karzinom des weichen Gaumens[C05.1 ] \ No newline at end of file diff --git a/476/ops_codes.txt b/476/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b1da37bd5cea4c1528758382ca7b6ed970b3212f --- /dev/null +++ b/476/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Partielle Exzision [erkrankter] harter und weicher Gaumen[5-272.1 ] \ No newline at end of file diff --git a/476/patient_clinical_data.json b/476/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..015f670f01e2b3a2afd0d3319cba06d9b765dd68 --- /dev/null +++ b/476/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 57, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/476/patient_pathological_data.json b/476/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a0246101355f8935954324e198267307c87885d4 --- /dev/null +++ b/476/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "476", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 53, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/476/surgery_description.txt b/476/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ab6802cce3ba6d869b2571e7fced1445d1df0d69 --- /dev/null +++ b/476/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy, Panendoscopy diff --git a/476/surgery_report.txt b/476/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1e1ac97ae56b47ab6ca015257860b948b159404 --- /dev/null +++ b/476/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater and positioning of the patient. Introductory consultation with the anesthesiologist and performance of the team time-out. Start with induction of ileus, for this reason tracheoscopy is omitted after consultation with anesthesia. Now esophagoscopy. This shows the small stomach filled with blood clots. No active bleeding or mass can be seen. On retraction, the entire length of the oesophagus is seen with a whitish coating and some reddish areas, but without evidence of deeper erosion or bleeding. Now panendoscopy. Inspection of the oral cavity reveals an ulcer approx. 1 1/2 cm long on the posterior palatal arch, which can be palpated as slightly hardened, and the upper tonsil pole on the left side is palpable. The palatal arch or glossotonsillar groove, tonsillar lobe and tongue are free on the right side. The base of the tongue is also palpable. The vallecula and epiglottis are also inconspicuous, as are the posterior and lateral pharyngeal walls. The piriform sinus can be opened very well on both sides. The postcricoid region also opens well and is free. In Cormack I, the vocal folds are easily adjustable up to the anterior commissure and are also inconspicuous. The Mc Ivor blade is now inserted and the mass removed by excisional biopsy with the helium laser. Care is taken to ensure that there is an approx. 1 cm margin around the mass. The left half of the uvula is missing. The tonsil itself is very small and remains intact. The specimen is marked with sutures and a resection is made in the lateral part if the mucosa hardens. The frozen section shows an invasive squamous cell carcinoma resected in sano. A piece of hardened mucosa that does not appear suspicious is resected as a lateral resection and sent for final histology. After a second look, there is no evidence of bleeding in the tonsil lobe. After a final consultation with the anesthesiologist, the operation is terminated. The patient should be presented at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/477/InvasionFront_CD3_block19_x5_y4_patient477_0.json b/477/InvasionFront_CD3_block19_x5_y4_patient477_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6aa9ea65e856947b0ef34e1f8baf93a567667b2f --- /dev/null +++ b/477/InvasionFront_CD3_block19_x5_y4_patient477_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17365.8, + "Centroid Y µm": 12743.3, + "Num Detections": 17739, + "Num Negative": 17556, + "Num Positive": 183, + "Positive %": 1.032, + "Num Positive per mm^2": 80.24 + } +} \ No newline at end of file diff --git a/477/InvasionFront_CD3_block19_x6_y4_patient477_1.json b/477/InvasionFront_CD3_block19_x6_y4_patient477_1.json new file mode 100644 index 0000000000000000000000000000000000000000..62e98251ce66d24e077593778b75f7b9a40e37ed --- /dev/null +++ b/477/InvasionFront_CD3_block19_x6_y4_patient477_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19939.4, + "Centroid Y µm": 12918.2, + "Num Detections": 21492, + "Num Negative": 20771, + "Num Positive": 721, + "Positive %": 3.355, + "Num Positive per mm^2": 290.72 + } +} \ No newline at end of file diff --git a/477/InvasionFront_CD8_block19_x5_y4_patient477_0.json b/477/InvasionFront_CD8_block19_x5_y4_patient477_0.json new file mode 100644 index 0000000000000000000000000000000000000000..441c0f518c8c3c61174a1c3f2180d9376b363960 --- /dev/null +++ b/477/InvasionFront_CD8_block19_x5_y4_patient477_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16916.0, + "Centroid Y µm": 20314.2, + "Num Detections": 22115, + "Num Negative": 21850, + "Num Positive": 265, + "Positive %": 1.198, + "Num Positive per mm^2": 117.11 + } +} \ No newline at end of file diff --git a/477/InvasionFront_CD8_block19_x6_y4_patient477_1.json b/477/InvasionFront_CD8_block19_x6_y4_patient477_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bfa2ba2cf7a01a3dbc9535990722cd702b6e341b --- /dev/null +++ b/477/InvasionFront_CD8_block19_x6_y4_patient477_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19464.7, + "Centroid Y µm": 20164.3, + "Num Detections": 26773, + "Num Negative": 26619, + "Num Positive": 154, + "Positive %": 0.5752, + "Num Positive per mm^2": 62.68 + } +} \ No newline at end of file diff --git a/477/TumorCenter_CD3_block19_x5_y4_patient477_0.json b/477/TumorCenter_CD3_block19_x5_y4_patient477_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0934fabd704174b3c80b3d0de5136fd73160ef44 --- /dev/null +++ b/477/TumorCenter_CD3_block19_x5_y4_patient477_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 10469.5, + "Num Detections": 26887, + "Num Negative": 25673, + "Num Positive": 1214, + "Positive %": 4.515, + "Num Positive per mm^2": 462.4 + } +} \ No newline at end of file diff --git a/477/TumorCenter_CD3_block19_x6_y4_patient477_1.json b/477/TumorCenter_CD3_block19_x6_y4_patient477_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9d68120cb179ea1005496d6225a54a59bf486e22 --- /dev/null +++ b/477/TumorCenter_CD3_block19_x6_y4_patient477_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 9819.8, + "Num Detections": 22532, + "Num Negative": 21983, + "Num Positive": 549, + "Positive %": 2.437, + "Num Positive per mm^2": 269.41 + } +} \ No newline at end of file diff --git a/477/TumorCenter_CD8_block19_x5_y4_patient477_0.json b/477/TumorCenter_CD8_block19_x5_y4_patient477_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1689932455b036d61b3728cd73412bde9bd9789b --- /dev/null +++ b/477/TumorCenter_CD8_block19_x5_y4_patient477_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 20913.9, + "Num Detections": 27207, + "Num Negative": 25712, + "Num Positive": 1495, + "Positive %": 5.495, + "Num Positive per mm^2": 566.44 + } +} \ No newline at end of file diff --git a/477/TumorCenter_CD8_block19_x6_y4_patient477_1.json b/477/TumorCenter_CD8_block19_x6_y4_patient477_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bd6e5c1d2f4a219caf2c825a06494e0910f8dbcb --- /dev/null +++ b/477/TumorCenter_CD8_block19_x6_y4_patient477_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21288.7, + "Centroid Y µm": 20839.0, + "Num Detections": 26216, + "Num Negative": 25775, + "Num Positive": 441, + "Positive %": 1.682, + "Num Positive per mm^2": 191.23 + } +} \ No newline at end of file diff --git a/477/history_text.txt b/477/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/477/icd_codes.txt b/477/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/477/ops_codes.txt b/477/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/477/patient_clinical_data.json b/477/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d7b28924ed3be60e1394def64be3fc78b1dfbf7b --- /dev/null +++ b/477/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 75, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/477/patient_pathological_data.json b/477/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..31669cff94853439551f18639099b31313b5436d --- /dev/null +++ b/477/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "477", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/477/surgery_description.txt b/477/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ec2bf5bff2abeae1fda21d84109eb822b2688bfc --- /dev/null +++ b/477/surgery_description.txt @@ -0,0 +1 @@ +Laser resection subglottic slope on the left, as well as Panendoscopy, PE (Proximal esophagus) on the right diff --git a/477/surgery_report.txt b/477/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/478/InvasionFront_CD3_block4_x1_y9_patient478_0.json b/478/InvasionFront_CD3_block4_x1_y9_patient478_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5cef35ccc60dd1a6b18e52bbda3aed33159110ab --- /dev/null +++ b/478/InvasionFront_CD3_block4_x1_y9_patient478_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 28509.9, + "Num Detections": 24782, + "Num Negative": 18164, + "Num Positive": 6618, + "Positive %": 26.7, + "Num Positive per mm^2": 2859.7 + } +} \ No newline at end of file diff --git a/478/InvasionFront_CD3_block4_x2_y9_patient478_1.json b/478/InvasionFront_CD3_block4_x2_y9_patient478_1.json new file mode 100644 index 0000000000000000000000000000000000000000..58cb84d243bfca7e19ec2a23044f10644f7071ca --- /dev/null +++ b/478/InvasionFront_CD3_block4_x2_y9_patient478_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8845.3, + "Centroid Y µm": 28484.9, + "Num Detections": 26874, + "Num Negative": 15558, + "Num Positive": 11316, + "Positive %": 42.11, + "Num Positive per mm^2": 4174.5 + } +} \ No newline at end of file diff --git a/478/InvasionFront_CD8_block4_x1_y9_patient478_0.json b/478/InvasionFront_CD8_block4_x1_y9_patient478_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4f6a0c102a06f5904f707a2144a4aadd28a36428 --- /dev/null +++ b/478/InvasionFront_CD8_block4_x1_y9_patient478_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 27485.4, + "Num Detections": 28337, + "Num Negative": 25487, + "Num Positive": 2850, + "Positive %": 10.06, + "Num Positive per mm^2": 1203.0 + } +} \ No newline at end of file diff --git a/478/InvasionFront_CD8_block4_x2_y9_patient478_1.json b/478/InvasionFront_CD8_block4_x2_y9_patient478_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9b55f7dcd8882f0082b402994586a5a93ec35069 --- /dev/null +++ b/478/InvasionFront_CD8_block4_x2_y9_patient478_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 27460.5, + "Num Detections": 27912, + "Num Negative": 22507, + "Num Positive": 5405, + "Positive %": 19.36, + "Num Positive per mm^2": 1992.6 + } +} \ No newline at end of file diff --git a/478/TumorCenter_CD3_block4_x1_y9_patient478_0.json b/478/TumorCenter_CD3_block4_x1_y9_patient478_0.json new file mode 100644 index 0000000000000000000000000000000000000000..71f49e68f83f75b62f4220eb61346b490b535107 --- /dev/null +++ b/478/TumorCenter_CD3_block4_x1_y9_patient478_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 23362.6, + "Num Detections": 26225, + "Num Negative": 15693, + "Num Positive": 10532, + "Positive %": 40.16, + "Num Positive per mm^2": 3891.6 + } +} \ No newline at end of file diff --git a/478/TumorCenter_CD3_block4_x2_y9_patient478_1.json b/478/TumorCenter_CD3_block4_x2_y9_patient478_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d52a62297cffefa6a31a099560c343afb6fb253b --- /dev/null +++ b/478/TumorCenter_CD3_block4_x2_y9_patient478_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 23237.7, + "Num Detections": 26484, + "Num Negative": 13067, + "Num Positive": 13417, + "Positive %": 50.66, + "Num Positive per mm^2": 5038.3 + } +} \ No newline at end of file diff --git a/478/TumorCenter_CD8_block4_x1_y9_patient478_0.json b/478/TumorCenter_CD8_block4_x1_y9_patient478_0.json new file mode 100644 index 0000000000000000000000000000000000000000..855b562f788abf7af88cac8205bd6a0d5bbcf187 --- /dev/null +++ b/478/TumorCenter_CD8_block4_x1_y9_patient478_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3598.1, + "Centroid Y µm": 22787.9, + "Num Detections": 26014, + "Num Negative": 18162, + "Num Positive": 7852, + "Positive %": 30.18, + "Num Positive per mm^2": 2895.3 + } +} \ No newline at end of file diff --git a/478/TumorCenter_CD8_block4_x2_y9_patient478_1.json b/478/TumorCenter_CD8_block4_x2_y9_patient478_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1c04dc05e8b07021f40f51dec95d6d12dc8a91d9 --- /dev/null +++ b/478/TumorCenter_CD8_block4_x2_y9_patient478_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 22812.9, + "Num Detections": 24500, + "Num Negative": 8813, + "Num Positive": 15687, + "Positive %": 64.03, + "Num Positive per mm^2": 5835.7 + } +} \ No newline at end of file diff --git a/478/history_text.txt b/478/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/478/icd_codes.txt b/478/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..764c0a75c604649542647f595e0a3350825c1908 --- /dev/null +++ b/478/icd_codes.txt @@ -0,0 +1 @@ +Neubildung bösartig sekundär und onA Lymphknoten Kopf Gesicht Hals[C77.0 L] \ No newline at end of file diff --git a/478/ops_codes.txt b/478/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c7d44930a4791f55cf36fd268495c4abc2c2061e --- /dev/null +++ b/478/ops_codes.txt @@ -0,0 +1 @@ +Laserkoagulation Pharynxgewebe[5-292.31 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] \ No newline at end of file diff --git a/478/patient_clinical_data.json b/478/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d3181bb9ca23548fcc187d0a5e725a6e0ccd3446 --- /dev/null +++ b/478/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 58, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 69, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/478/patient_pathological_data.json b/478/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..514531ef3eedcf594cd743b7c7be02983c33bf1f --- /dev/null +++ b/478/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "478", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 11, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/478/surgery_description.txt b/478/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..55454b577cb25153ef5ac841798abf43e83f2e76 --- /dev/null +++ b/478/surgery_description.txt @@ -0,0 +1 @@ +Transoral laser resection, Modified radical neck dissection diff --git a/478/surgery_report.txt b/478/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..93cd1a44a2c9d87ad62f2e39b6af80c5493e8b2f --- /dev/null +++ b/478/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by anesthesia colleagues using a laser tube. At the beginning of the operation, insertion with the flexible esophagogastroscope. Pre-viewing into the stomach. If diaphanoscopy is good, the PEG is inserted using the thread pull-through method. This is successful without any problems. Positioning the tumor. The tumor is relatively difficult to access. It is located in the glossotonsillar groove with transition to the base of the tongue. The patient has very protruding teeth, so the tumor can only be adjusted to a medium degree. The tumor itself is blurred and can hardly be distinguished from the rest of the tissue. Therefore, extremely difficult conditions for the laser resection requested by the tumor board and the patient. Nevertheless, the tumor was successfully resected first in the caudal region and then in the cranial region. Switching on the microscope and the laser. Start of laser resection with 5 watts in the caudal area. Then pre-laser cranially and laterally. The tumor can be removed in its entirety. At the end, marginal samples are taken and sent for frozen section. All marginal samples are tumor-free. The final specimen is placed on cork and sent to the pathology department. Insertion of suprarenal swabs. Rearrangement for neck dissection on the left side: A scar is visible here which is located exactly transversely between two skin folds. The scar is partially integrated into the new skin incision, which then runs into a natural skin fold. Cutting through the platysma. Raising the platysma. Exposure of the submandibular gland. Exposure of the sternocleidomastoid muscle. The sternocleidomastoid muscle is extremely scarred. Here there is a post lymph node removal. The entire muscle and the surrounding tissue is firmly attached to the internal jugular vein. This must be carefully and sharply separated. Exposure of the omohyoid muscle and free preparation of the cervical vascular sheath. Removal of the neck preparation II a to V a while sparing the plexus branches and protecting the accessorius nerve. Hemostasis using bipolar coagulation. Insertion of a Redon drainage. Two-layer wound closure. Completion of the neck dissection. Inspection of the oropharynx again. Removal of the swabs. Hemostasis using monopolar coagulation. Due to the superficiality of the defect, a tracheotomy is not performed. \ No newline at end of file diff --git a/479/InvasionFront_CD3_block20_x3_y8_patient479_0.json b/479/InvasionFront_CD3_block20_x3_y8_patient479_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fbcf43b94a5e4f3de2739737bc0a5b78508a3827 --- /dev/null +++ b/479/InvasionFront_CD3_block20_x3_y8_patient479_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11843.7, + "Centroid Y µm": 19739.5, + "Num Detections": 19622, + "Num Negative": 18766, + "Num Positive": 856, + "Positive %": 4.362, + "Num Positive per mm^2": 389.99 + } +} \ No newline at end of file diff --git a/479/InvasionFront_CD3_block20_x4_y8_patient479_1.json b/479/InvasionFront_CD3_block20_x4_y8_patient479_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f89b5126b8aef19105822e7210eb65e15336c105 --- /dev/null +++ b/479/InvasionFront_CD3_block20_x4_y8_patient479_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14392.4, + "Centroid Y µm": 20014.4, + "Num Detections": 18123, + "Num Negative": 17232, + "Num Positive": 891, + "Positive %": 4.916, + "Num Positive per mm^2": 392.06 + } +} \ No newline at end of file diff --git a/479/InvasionFront_CD8_block20_x3_y8_patient479_0.json b/479/InvasionFront_CD8_block20_x3_y8_patient479_0.json new file mode 100644 index 0000000000000000000000000000000000000000..02df3f749fd84982b97c9d36708a276ff854cfb1 --- /dev/null +++ b/479/InvasionFront_CD8_block20_x3_y8_patient479_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12041.1, + "Centroid Y µm": 20164.8, + "Num Detections": 4244, + "Num Negative": 3804, + "Num Positive": 440, + "Positive %": 10.37, + "Num Positive per mm^2": 790.0 + } +} \ No newline at end of file diff --git a/479/InvasionFront_CD8_block20_x4_y8_patient479_1.json b/479/InvasionFront_CD8_block20_x4_y8_patient479_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9304f10df8ff084b87a2934be99c365a385f932c --- /dev/null +++ b/479/InvasionFront_CD8_block20_x4_y8_patient479_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14611.1, + "Centroid Y µm": 20078.9, + "Num Detections": 16322, + "Num Negative": 15333, + "Num Positive": 989, + "Positive %": 6.059, + "Num Positive per mm^2": 460.69 + } +} \ No newline at end of file diff --git a/479/TumorCenter_CD3_block20_x3_y8_patient479_0.json b/479/TumorCenter_CD3_block20_x3_y8_patient479_0.json new file mode 100644 index 0000000000000000000000000000000000000000..787c87eea3a264bbadfefe5aa2ceba35cf10f6da --- /dev/null +++ b/479/TumorCenter_CD3_block20_x3_y8_patient479_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11152.5, + "Centroid Y µm": 19148.0, + "Num Detections": 10602, + "Num Negative": 10528, + "Num Positive": 74, + "Positive %": 0.698, + "Num Positive per mm^2": 34.64 + } +} \ No newline at end of file diff --git a/479/TumorCenter_CD3_block20_x4_y8_patient479_1.json b/479/TumorCenter_CD3_block20_x4_y8_patient479_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3d1c249d46d0766d624ab2e4256b626feceef71d --- /dev/null +++ b/479/TumorCenter_CD3_block20_x4_y8_patient479_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13734.5, + "Centroid Y µm": 19174.9, + "Num Detections": 10537, + "Num Negative": 10361, + "Num Positive": 176, + "Positive %": 1.67, + "Num Positive per mm^2": 82.94 + } +} \ No newline at end of file diff --git a/479/TumorCenter_CD8_block20_x3_y8_patient479_0.json b/479/TumorCenter_CD8_block20_x3_y8_patient479_0.json new file mode 100644 index 0000000000000000000000000000000000000000..13803b265d461a121205578e41c49c9bad46abd3 --- /dev/null +++ b/479/TumorCenter_CD8_block20_x3_y8_patient479_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 20114.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/479/TumorCenter_CD8_block20_x4_y8_patient479_1.json b/479/TumorCenter_CD8_block20_x4_y8_patient479_1.json new file mode 100644 index 0000000000000000000000000000000000000000..49fce85b11661ba65348b8da44d0df8b3cdb85a3 --- /dev/null +++ b/479/TumorCenter_CD8_block20_x4_y8_patient479_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 19914.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/479/history_text.txt b/479/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7e4ebe1ace9612c8617e3eba8c8ed3c91f55438b --- /dev/null +++ b/479/history_text.txt @@ -0,0 +1 @@ +A cT3 cN0-glottic laryngeal carcinoma was histologically confirmed in the patient during a panendoscopy <2014>. Clear destruction of the cartilage on CT. Laryngectomy was therefore indicated. \ No newline at end of file diff --git a/479/icd_codes.txt b/479/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/479/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/479/ops_codes.txt b/479/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..05f1e1479ea3e6a43b1ee18818faaffefc3b7fe1 --- /dev/null +++ b/479/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Hemithyroidektomie ohne Parathyreoidektomie[5-061.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/479/patient_clinical_data.json b/479/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..223087011cc3bbdf82c95af52fe97330b218fd6a --- /dev/null +++ b/479/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 80, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 9, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/479/patient_pathological_data.json b/479/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3ca9087afba78489c2e1c861d7de7f407eecaee5 --- /dev/null +++ b/479/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "479", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 23, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/479/surgery_description.txt b/479/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..90a7ade0545090378e1cfc455249e1c9741efcc4 --- /dev/null +++ b/479/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Functional bilateral neck dissection, Provox placement, Hemithyroidectomy diff --git a/479/surgery_report.txt b/479/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0a81da32ce9e83a99799486cc0bb81213e38e65f --- /dev/null +++ b/479/surgery_report.txt @@ -0,0 +1 @@ +Preparation and intubation by anesthesia colleagues. First positioning of the patient, preliminary consultation with the anesthesia colleagues. First perform a pharyngo-laryngoscopy. This involves entering with the Kleinsasser tube under dental protection. The tumorous process is seen in the endolaryngeal region, particularly anteriorly located with infiltration of both vocal folds and clear growth towards the laryngeal skeleton. Therefore, in conjunction with the CT diagnosis, confirmation of the indication for laryngectomy. No evidence of infiltration of the supraglottic structures and extension towards the hypopharynx. Here, all mucosa is unremarkable and tumor-free. A nasogastric feeding tube was then inserted under pharyngoscopic control. Injection of xylocaine with added adrenaline. Dissection of an apron flap. Exposure of both sides of the sternocleidomastoid muscle, the submandibular gland and the digastric muscle. Due to the course, the facial vein is removed in good time. Neck dissection performed first. Start with the left side. Here, after exposure of the omohyoid muscle, free preparation of the internal jugular vein, exposure of the vagus nerve, common carotid artery, clearing of the anterior neck preparation while carefully protecting the cervical anus, the hypoglossal nerve and the superior thyroid artery. Exposure of the accessorius nerve and en bloc removal of the neck preparation. All exposed nerve structures are returned to their tissue bed after release. Exactly the same procedure on the opposite side. Here too, the accessorius nerve, vagus nerve and hypoglossal nerve are exposed. Subsequent neurolysis and re-embedding of the structures. Free preparation of the internal jugular vein and, together with level VI, removal of the neck preparation en block. Skeletonization of the laryngeal skeleton and release on both sides of the piriform sinus, release of the hyoid. This is followed by the trachatomy. This is done between the cricoid cartilage and the first tracheal ring. The thyroid isthmus is severed for this purpose. Successive release of the left thyroid lobe, which was clearly conspicuous due to nodules measuring up to 2 cm. This can be correlated well with the sonographic findings intraoperatively. Visualization of the recurrent nerve. Ligation of the thyroid gland close to the capsule. Ligation of the superior and inferior thyroid artery and the middle thyroid vein. The tumor is then resected. This involves entering the center of the vallecula, looping the epiglottis and successively widening the pharyngeal access. Mucosa-sparing resection and release of the laryngeal skeleton and removal of the laryngeal skeleton below the cricoid cartilage. Careful inspection. The glottic laryngeal carcinoma is exclusively endolaryngeal. This results in a safe in sano resection. The Provox prosthesis is then placed using the usual pull-through method. This is successful without any problems. Insertion of a 6 mm prosthesis. The paramedian myotomy is then performed in the area of the upper esophageal sphincter. Later, the sternal attachments of the sternocleidomastoid muscle are cut on both sides. The pharyngeal suture is then performed inverted and in multiple layers. Subsequently, insertion of a 10-gauge redon drain in each case. Careful two-layer wound closure and suturing of the tracheostoma. Subsequent problem-free transfer to a size 10 low-cuff cannula and completion of the procedure without any indication of complications. \ No newline at end of file diff --git a/480/InvasionFront_CD3_block17_x1_y11_patient480_0.json b/480/InvasionFront_CD3_block17_x1_y11_patient480_0.json new file mode 100644 index 0000000000000000000000000000000000000000..305d79ad422989e3cfeeaab408cc16d43d76a1d2 --- /dev/null +++ b/480/InvasionFront_CD3_block17_x1_y11_patient480_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3348.2, + "Centroid Y µm": 32407.8, + "Num Detections": 17887, + "Num Negative": 17117, + "Num Positive": 770, + "Positive %": 4.305, + "Num Positive per mm^2": 336.41 + } +} \ No newline at end of file diff --git a/480/InvasionFront_CD3_block17_x2_y11_patient480_1.json b/480/InvasionFront_CD3_block17_x2_y11_patient480_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6ee4afb63c186dc31e9a541af3fc9077dc20d3f0 --- /dev/null +++ b/480/InvasionFront_CD3_block17_x2_y11_patient480_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5722.0, + "Centroid Y µm": 32432.8, + "Num Detections": 18251, + "Num Negative": 17188, + "Num Positive": 1063, + "Positive %": 5.824, + "Num Positive per mm^2": 457.21 + } +} \ No newline at end of file diff --git a/480/InvasionFront_CD8_block17_x1_y11_patient480_0.json b/480/InvasionFront_CD8_block17_x1_y11_patient480_0.json new file mode 100644 index 0000000000000000000000000000000000000000..92b56fd3047269665f9e686d5746b6833fde9c1c --- /dev/null +++ b/480/InvasionFront_CD8_block17_x1_y11_patient480_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 27410.5, + "Num Detections": 15044, + "Num Negative": 14712, + "Num Positive": 332, + "Positive %": 2.207, + "Num Positive per mm^2": 160.88 + } +} \ No newline at end of file diff --git a/480/InvasionFront_CD8_block17_x2_y11_patient480_1.json b/480/InvasionFront_CD8_block17_x2_y11_patient480_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d9cd7d135c413a0042ad240a520c2b32bf394d8 --- /dev/null +++ b/480/InvasionFront_CD8_block17_x2_y11_patient480_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 27460.5, + "Num Detections": 15049, + "Num Negative": 14594, + "Num Positive": 455, + "Positive %": 3.023, + "Num Positive per mm^2": 231.39 + } +} \ No newline at end of file diff --git a/480/TumorCenter_CD3_block17_x1_y11_patient480_0.json b/480/TumorCenter_CD3_block17_x1_y11_patient480_0.json new file mode 100644 index 0000000000000000000000000000000000000000..567f11651e47eb125abae44de419c628bca87a21 --- /dev/null +++ b/480/TumorCenter_CD3_block17_x1_y11_patient480_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 26985.7, + "Num Detections": 20054, + "Num Negative": 17815, + "Num Positive": 2239, + "Positive %": 11.16, + "Num Positive per mm^2": 935.22 + } +} \ No newline at end of file diff --git a/480/TumorCenter_CD3_block17_x2_y11_patient480_1.json b/480/TumorCenter_CD3_block17_x2_y11_patient480_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0b7c3e265efa3b656ce7f1fa8c190b3a0813830c --- /dev/null +++ b/480/TumorCenter_CD3_block17_x2_y11_patient480_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 27235.6, + "Num Detections": 10482, + "Num Negative": 8787, + "Num Positive": 1695, + "Positive %": 16.17, + "Num Positive per mm^2": 1309.4 + } +} \ No newline at end of file diff --git a/480/TumorCenter_CD8_block17_x1_y11_patient480_0.json b/480/TumorCenter_CD8_block17_x1_y11_patient480_0.json new file mode 100644 index 0000000000000000000000000000000000000000..78eda88961863a5ca08cd93f6a1c7090e1b75cb5 --- /dev/null +++ b/480/TumorCenter_CD8_block17_x1_y11_patient480_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6543.9, + "Centroid Y µm": 40948.7, + "Num Detections": 18268, + "Num Negative": 16411, + "Num Positive": 1857, + "Positive %": 10.17, + "Num Positive per mm^2": 786.71 + } +} \ No newline at end of file diff --git a/480/TumorCenter_CD8_block17_x2_y11_patient480_1.json b/480/TumorCenter_CD8_block17_x2_y11_patient480_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1ef1f14eefe3fec92b787ff55a2d3c1a059fbd50 --- /dev/null +++ b/480/TumorCenter_CD8_block17_x2_y11_patient480_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9195.1, + "Centroid Y µm": 40978.3, + "Num Detections": 21735, + "Num Negative": 20281, + "Num Positive": 1454, + "Positive %": 6.69, + "Num Positive per mm^2": 626.96 + } +} \ No newline at end of file diff --git a/480/history_text.txt b/480/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d8741763f0670a416c09321c93f128cec99df4dd --- /dev/null +++ b/480/history_text.txt @@ -0,0 +1 @@ +Patient with a histologically confirmed G2 squamous cell carcinoma cT2 cN0 of the right glottis with subglottic spread and indication for the above-mentioned measures due to poor adjustability. \ No newline at end of file diff --git a/480/icd_codes.txt b/480/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/480/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/480/ops_codes.txt b/480/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2468436dce26bdc120c9d57400cad62a78162ab --- /dev/null +++ b/480/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/480/patient_clinical_data.json b/480/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e21123858b8e01211d387d4a31b7d6a44022948d --- /dev/null +++ b/480/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 39, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/480/patient_pathological_data.json b/480/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d6b10351a59c631e4d23e16649cc6d9f9bfed93c --- /dev/null +++ b/480/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "480", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/480/surgery_description.txt b/480/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..857279ae31e28e968828bfc2b8899de4b2c1e7cd --- /dev/null +++ b/480/surgery_description.txt @@ -0,0 +1 @@ +Partial larynx resection according to Leroux-Robert, Endoscopy diff --git a/480/surgery_report.txt b/480/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..23b3b5cc1bb95b87b3ac34cd4235179bafabd1a1 --- /dev/null +++ b/480/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia and performance of tracheoscopy using 0° optics. Inconspicuous conditions in the area of the trachea up to the carina. Then transoral endotracheal intubation and positioning of the patient by the surgeon. Laryngoscopy is performed using a Kleinsasser D-tube. An exophytic, centrally ulcerated mass was found in the middle and anterior third of the right vocal fold, which had spread to the subglottic slope of the right vocal fold; the pocket fold, the morgue sinus and the anterior commissure were not affected by the tumor. Due to the poor adjustability, the indication for transcervical partial laryngectomy was confirmed. Skin spray disinfection and application of local anesthesia in a skin fold at the level of the thyroid cartilage, skin ablation and sterile draping. Make a horizontal skin incision approx. 4 cm long, cut through the subcutaneous tissue and the platysma. Creation of a subplatysmal flap cranially, above the thyroid incisura caudally up to the level of the cricoid cartilage. Exposure of the prelaryngeal musculature. Cut through it in the midline. Exposure of the cricothyroid membrane and the ligamentum conicum. Horizontal incision of the ligamentum conicum and opening of the laryngeal lumen subglottically. Paramedian periosteal incision on the thyroid cartilage on the left. Formation of 2 perichondrium leaves laterally pedicled. Paramedian thyroidectomy on the left using a wheel and opening of the laryngeal lumen at the supraglottic level. Inspection of the findings from the cranial side and subsequent subperichondrial dissection on the right side. Inclusion of the endochondrium of the thyroid cartilage in the tumor preparation. Cut around the tumor preparation with a large safety margin supra- and subglottically. Posteriorly, the vocal process is exposed, but is spared during resection. The specimen is sent in thread-marked for final histology. Subsequently, 5 marginal samples are taken (supraglottic right, subglottic right, posterior towards the vocal process of the arytenoid cartilage, wound bed, anterior commissure and anterior third of the left vocal fold). All marginal samples were found to be tumor-free by the pathology colleagues during the frozen section examination. Hemostasis in the resection area. Subsequently, 4 drill holes were made in the thyroid cartilage and, due to the lack of corresponding wound surfaces, the decision was made to close the primary thyroid cartilage using 2 Vicryl 3-0 sutures. Subsequent suture adaptation of the ligamentum conicum. Knockback of the perichondrium leaves. Creation of a prelaryngeal flap. Suture adaptation of the prelaryngeal muscles in the midline. Platysma suture. Single button skin suture. Application of a pressure bandage and completion of the procedure without complications. The patient received intraoperative single shot ceftriaxone 2 g intravenously. Voice protection is recommended for 5 days. Please organize control MLE in 6 to 8 weeks after receiving the final histology. \ No newline at end of file diff --git a/481/InvasionFront_CD3_block18_x1_y7_patient481_0.json b/481/InvasionFront_CD3_block18_x1_y7_patient481_0.json new file mode 100644 index 0000000000000000000000000000000000000000..535a1edbe2f9f0a990f7d0527b11472299b5213b --- /dev/null +++ b/481/InvasionFront_CD3_block18_x1_y7_patient481_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.1, + "Centroid Y µm": 22038.3, + "Num Detections": 17905, + "Num Negative": 17146, + "Num Positive": 759, + "Positive %": 4.239, + "Num Positive per mm^2": 401.0 + } +} \ No newline at end of file diff --git a/481/InvasionFront_CD3_block18_x2_y7_patient481_1.json b/481/InvasionFront_CD3_block18_x2_y7_patient481_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2d66819d074df00560c434b58ec9679f953c9b58 --- /dev/null +++ b/481/InvasionFront_CD3_block18_x2_y7_patient481_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 22063.3, + "Num Detections": 16423, + "Num Negative": 15211, + "Num Positive": 1212, + "Positive %": 7.38, + "Num Positive per mm^2": 597.44 + } +} \ No newline at end of file diff --git a/481/InvasionFront_CD8_block18_x1_y7_patient481_0.json b/481/InvasionFront_CD8_block18_x1_y7_patient481_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2845c4f4062928582f639a3e1e6721cbd5c12145 --- /dev/null +++ b/481/InvasionFront_CD8_block18_x1_y7_patient481_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4147.8, + "Centroid Y µm": 25086.7, + "Num Detections": 16882, + "Num Negative": 16644, + "Num Positive": 238, + "Positive %": 1.41, + "Num Positive per mm^2": 124.94 + } +} \ No newline at end of file diff --git a/481/InvasionFront_CD8_block18_x2_y7_patient481_1.json b/481/InvasionFront_CD8_block18_x2_y7_patient481_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a70edab54a6e4b733da3150d3dd424408db03673 --- /dev/null +++ b/481/InvasionFront_CD8_block18_x2_y7_patient481_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6696.5, + "Centroid Y µm": 25136.7, + "Num Detections": 18012, + "Num Negative": 17262, + "Num Positive": 750, + "Positive %": 4.164, + "Num Positive per mm^2": 378.08 + } +} \ No newline at end of file diff --git a/481/TumorCenter_CD3_block18_x1_y7_patient481_0.json b/481/TumorCenter_CD3_block18_x1_y7_patient481_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b02b95c74c9d05c4949836d3c6c7aa15046fc44d --- /dev/null +++ b/481/TumorCenter_CD3_block18_x1_y7_patient481_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3531.4, + "Centroid Y µm": 16824.9, + "Num Detections": 11732, + "Num Negative": 11692, + "Num Positive": 40, + "Positive %": 0.3409, + "Num Positive per mm^2": 21.28 + } +} \ No newline at end of file diff --git a/481/TumorCenter_CD3_block18_x2_y7_patient481_1.json b/481/TumorCenter_CD3_block18_x2_y7_patient481_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a28b49334da10aaa0ccff7a7f7ffc18499571ca0 --- /dev/null +++ b/481/TumorCenter_CD3_block18_x2_y7_patient481_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5971.8, + "Centroid Y µm": 16941.1, + "Num Detections": 15383, + "Num Negative": 15038, + "Num Positive": 345, + "Positive %": 2.243, + "Num Positive per mm^2": 193.3 + } +} \ No newline at end of file diff --git a/481/TumorCenter_CD8_block18_x1_y7_patient481_0.json b/481/TumorCenter_CD8_block18_x1_y7_patient481_0.json new file mode 100644 index 0000000000000000000000000000000000000000..758735a9c032de6cc898bcb62b62ae2394e4f895 --- /dev/null +++ b/481/TumorCenter_CD8_block18_x1_y7_patient481_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3373.2, + "Centroid Y µm": 17615.7, + "Num Detections": 12005, + "Num Negative": 11970, + "Num Positive": 35, + "Positive %": 0.2915, + "Num Positive per mm^2": 20.6 + } +} \ No newline at end of file diff --git a/481/TumorCenter_CD8_block18_x2_y7_patient481_1.json b/481/TumorCenter_CD8_block18_x2_y7_patient481_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b7f657b31b42717aab2866fd3909b66e48fc99f8 --- /dev/null +++ b/481/TumorCenter_CD8_block18_x2_y7_patient481_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 17715.6, + "Num Detections": 14362, + "Num Negative": 14291, + "Num Positive": 71, + "Positive %": 0.4944, + "Num Positive per mm^2": 39.5 + } +} \ No newline at end of file diff --git a/481/history_text.txt b/481/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4e12b361af5e81321ea5c8607376e5a6639ffa74 --- /dev/null +++ b/481/history_text.txt @@ -0,0 +1 @@ +Patient with a histologically proven G2 squamous cell carcinoma of the glottis and right subglottis with vocal fold arrest on the right side and a spread towards the subglottis of approx. 15 mm and indication, after patient presentation in our interdisciplinary tumor conference, for the above-mentioned measures. \ No newline at end of file diff --git a/481/icd_codes.txt b/481/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c524169f7565f12e153db0fa9bd192bc0fa146d7 --- /dev/null +++ b/481/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Larynx[D38.0 ] \ No newline at end of file diff --git a/481/ops_codes.txt b/481/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2187552278169468b1a418f2e80fa9e00c7d9dc5 --- /dev/null +++ b/481/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Einlegen einer Stimmprothese[5-319.9 ] Krikopharyngeale Myotomie[5-290.x ] \ No newline at end of file diff --git a/481/patient_clinical_data.json b/481/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..14c273076e1f9650322d6dce4cca1f06bda316c2 --- /dev/null +++ b/481/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/481/patient_pathological_data.json b/481/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e54ff2a6072aedeb68e7135555605cdfe2ef3069 --- /dev/null +++ b/481/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "481", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 57, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/481/surgery_description.txt b/481/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..da9e368deb9a9cb600264379fd349afc7482e0ab --- /dev/null +++ b/481/surgery_description.txt @@ -0,0 +1 @@ +Laryngoscopy, Laryngo-esophagectomy, Bilateral neck dissection diff --git a/481/surgery_report.txt b/481/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e63efab4fc94c9eca480140056075df98882dba8 --- /dev/null +++ b/481/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia and transoral endotracheal intubation by the anesthesia colleagues and positioning of the patient by the surgeon. Perform a laryngoscopy using a Kleinsasser C-tube. Adjustment of the endolarynx. This revealed an exophytic mass occupying the entire right vocal fold, spreading to the opposite side in the anterior commissure and extending approx. 15 mm subglottically to the right side. Thus, after confirmation of the findings, cervical skin spray disinfection, application of local anesthesia, skin ablation and sterile covering. Creation of a skin incision, cutting of the subcutaneous tissue and the platysma. Creation of an apron flap cranially up to the level of the hyoid bone or up to the capsule of the submandibular gland on both sides. Exposure of the anterior jugular vein. Exposure of the anterior border of the sternocleidomastoid muscle on both sides. Exposure of the posterior venter of the digaster muscle on the right. Exposure of the accessorius nerve. Exposure of the omohyoid muscle on the right. Exposure of the cervical vascular sheath. Successive removal of the posterior and anterior neck specimen while protecting the above-mentioned structures and the plexus branches. Reposition the patient on the left side to perform the neck dissection. Exposure of the accessorius nerve, the digastric muscle and the omohyoid muscle. Exposure of the cervical vascular sheath. Successive removal of the posterior and anterior neck preparation while protecting the above-mentioned structures and the plexus branches. Hemostasis on both sides. Dry conditions. Subsequent exposure of the thyroid cartilage of the cricothyroid membrane, the cricoid cartilage and the anterior wall of the trachea. Exposure and dissection of the thyroid isthmus. Lateral dissection of the trachea and larynx. Perichondrium incision on the thyroid cartilage. Formation of a laterally pedicled perichondrium flap. Skeletonization of the upper horn of the thyroid cartilage. Exposure of the wall of the piriform sinus on both sides. Dissection of the piriform sinus from the inner surface of the thyroid cartilage under a strictly subperichondrial dissection. Subsequent skeletonization of the hyoid bone. Transverse dissection of the base of the infrahyoid musculature. Subsequent visualization of the pre-epiglottic fatty tissue. Exposure of the epiglottis. Exposure of its free edge. Pharyngotomy. Dissection along the lateral epiglottis and then along the aryepiglottic folds on both sides. Maximum protection of the mucosa of the piriform sinus on both sides. Transverse incision postcricoid. Joining of all incisions and subsequent dissection between the trachea and esophagus. Prior to this, an incision was made between the 2nd and 3rd tracheal cartilage clasp and the tracheostoma was epithelized caudally. Problem-free resection of the specimen, which is sent for intraoperative frozen section examination. The intraoperative frozen section examination reveals an R0 situation at all resection margins. Subsequent placement of an 8 mm Provox prosthesis in the typical manner. Dry conditions. Following pharyngeal suturing, a first layer is sutured together at the mucosal level. Care is taken to ensure that the mucosa is completely covered by the suture. A 2nd layer is then created at the level of the submucosa. The muscles of the hypopharynx are then sutured together as the 3rd layer. As the 4th layer, the infrahyoid muscles are sutured together in the midline. The pharyngeal suture is then additionally reinforced using pieces of Tachosil, which were previously cut to size. Dry conditions. Irrigation of the wound using hydrogen peroxide and Ringer's solution. Dry conditions. Placement of a 10 Redon drain on both sides. Completion of the epithelialization of the tracheostoma. Two-layer wound closure. Recannulation of the patient to a size 8 Rügheimer cannula. Completion of the procedure without complications. Conclusion: Laryngoscopy, total laryngectomy, modified radical neck dissection on both sides of region II to V and insertion of a size 8 Provox prosthesis in a cT3 cN0 G2 squamous cell carcinoma of the right glottis. The intraoperative frozen section examination revealed an R0 situation. Please X-ray pap smear in 10 days and present the patient to our tumor conference after receiving the final histology in order to plan further measures. \ No newline at end of file diff --git a/482/InvasionFront_CD3_block12_x1_y5_patient482_0.json b/482/InvasionFront_CD3_block12_x1_y5_patient482_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e9a93c002a91d231dc3e7b5b20d4527353f7ef4 --- /dev/null +++ b/482/InvasionFront_CD3_block12_x1_y5_patient482_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4047.9, + "Centroid Y µm": 16741.1, + "Num Detections": 24340, + "Num Negative": 22143, + "Num Positive": 2197, + "Positive %": 9.026, + "Num Positive per mm^2": 857.17 + } +} \ No newline at end of file diff --git a/482/InvasionFront_CD3_block12_x2_y5_patient482_1.json b/482/InvasionFront_CD3_block12_x2_y5_patient482_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a1dca16ff080a03d96f1f735c2877023bd508244 --- /dev/null +++ b/482/InvasionFront_CD3_block12_x2_y5_patient482_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 16891.1, + "Num Detections": 23695, + "Num Negative": 21493, + "Num Positive": 2202, + "Positive %": 9.293, + "Num Positive per mm^2": 938.11 + } +} \ No newline at end of file diff --git a/482/InvasionFront_CD8_block12_x1_y5_patient482_0.json b/482/InvasionFront_CD8_block12_x1_y5_patient482_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ef3c4608d23de6e58830b726d700347b29f58fd4 --- /dev/null +++ b/482/InvasionFront_CD8_block12_x1_y5_patient482_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4422.7, + "Centroid Y µm": 16716.1, + "Num Detections": 24344, + "Num Negative": 20905, + "Num Positive": 3439, + "Positive %": 14.13, + "Num Positive per mm^2": 1323.4 + } +} \ No newline at end of file diff --git a/482/InvasionFront_CD8_block12_x2_y5_patient482_1.json b/482/InvasionFront_CD8_block12_x2_y5_patient482_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eedb3c90922520037630b0807f9699e19cc7fe4b --- /dev/null +++ b/482/InvasionFront_CD8_block12_x2_y5_patient482_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7146.2, + "Centroid Y µm": 16516.3, + "Num Detections": 22540, + "Num Negative": 20288, + "Num Positive": 2252, + "Positive %": 9.991, + "Num Positive per mm^2": 952.05 + } +} \ No newline at end of file diff --git a/482/TumorCenter_CD3_block12_x1_y5_patient482_0.json b/482/TumorCenter_CD3_block12_x1_y5_patient482_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6079afcf8bba4c38e2d035d6abc23edeb5d2b64e --- /dev/null +++ b/482/TumorCenter_CD3_block12_x1_y5_patient482_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 12343.5, + "Num Detections": 24689, + "Num Negative": 22463, + "Num Positive": 2226, + "Positive %": 9.016, + "Num Positive per mm^2": 925.14 + } +} \ No newline at end of file diff --git a/482/TumorCenter_CD3_block12_x2_y5_patient482_1.json b/482/TumorCenter_CD3_block12_x2_y5_patient482_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e48a7c25f0ce07bd09c4af5ce0c9cdacc6e5657 --- /dev/null +++ b/482/TumorCenter_CD3_block12_x2_y5_patient482_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 12368.5, + "Num Detections": 20983, + "Num Negative": 15888, + "Num Positive": 5095, + "Positive %": 24.28, + "Num Positive per mm^2": 2158.6 + } +} \ No newline at end of file diff --git a/482/TumorCenter_CD8_block12_x1_y5_patient482_0.json b/482/TumorCenter_CD8_block12_x1_y5_patient482_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e4d3f448ccc40e089bddb383d2f28c3f0f8eb3ef --- /dev/null +++ b/482/TumorCenter_CD8_block12_x1_y5_patient482_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6896.3, + "Centroid Y µm": 21463.6, + "Num Detections": 21481, + "Num Negative": 20896, + "Num Positive": 585, + "Positive %": 2.723, + "Num Positive per mm^2": 245.59 + } +} \ No newline at end of file diff --git a/482/TumorCenter_CD8_block12_x2_y5_patient482_1.json b/482/TumorCenter_CD8_block12_x2_y5_patient482_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f3acdc82f4d370448affbb112c3c5d0ab2c022d --- /dev/null +++ b/482/TumorCenter_CD8_block12_x2_y5_patient482_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9445.0, + "Centroid Y µm": 21563.6, + "Num Detections": 21050, + "Num Negative": 18679, + "Num Positive": 2371, + "Positive %": 11.26, + "Num Positive per mm^2": 1015.6 + } +} \ No newline at end of file diff --git a/482/history_text.txt b/482/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..38714c0321231e732059f8202a99a09040f13e42 --- /dev/null +++ b/482/history_text.txt @@ -0,0 +1 @@ +The patient has had tonsillitis requiring antibiotics several times a year for about 15 years with constant dysphagia and difficulty swallowing in the winter months. Clinical examination revealed pronounced tonsillar hyperplasia, particularly on the left. Therefore indication for the above procedure. \ No newline at end of file diff --git a/482/icd_codes.txt b/482/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6850cfbd389c235b7650359a41c9a0de70ad0e24 --- /dev/null +++ b/482/icd_codes.txt @@ -0,0 +1 @@ +Tonsillitis chronisch[J35.0 ] \ No newline at end of file diff --git a/482/ops_codes.txt b/482/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5255f9ea6764c3937fab2f9699e25c73f57437f5 --- /dev/null +++ b/482/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie mit Dissektionstechnik[5-281.0 ] \ No newline at end of file diff --git a/482/patient_clinical_data.json b/482/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..57f3c64a59d72bdb148adccf57afae10449a8c43 --- /dev/null +++ b/482/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 50, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/482/patient_pathological_data.json b/482/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d4d84aa0eba515c5a54f69b9410cc27e9c8d1ef8 --- /dev/null +++ b/482/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "482", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/482/surgery_description.txt b/482/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1af7e2f1faec5e004716f9ccf9c7331a17b8e39e --- /dev/null +++ b/482/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy (without adenotonsillectomy): With dissection technique diff --git a/482/surgery_report.txt b/482/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b0c12f0447212694966355c633655e6716b0d4ed --- /dev/null +++ b/482/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and endotracheal intubation by the anesthesia colleagues, repositioning of the patient for TE on the right side: grasping the tonsil with the tonsil forceps and dislocation from the tonsil bed. Make a small incision on the anterior palatal arch to locate the capsule and carefully cut through the tissue to the capsule. Then careful dissection using the dissection technique and dissection of the tonsil up to the lower tonsil pole. Subsequently, careful bipolar coagulation of the lower tonsil pole and dissection of the tissue. Insertion of 2 hydrogen swabs and turning to the left side: Here you can see a pronounced tonsil hyperplasia, which is irregular and could be suspicious of a tumor. After demonstration of the findings to , the same procedure with the dissection technique. Locate the capsule while protecting the anterior palatal arch and dislocate the tonsil with the tonsil forceps. Difficult preparation conditions here. The tonsil is firmly fused to the palatal arch and massively scarred. Dissection is bloody and the capsule is not easy to find. Dissection up to the lower tonsil pole with difficulty and separation of the tissue after careful bipolar coagulation. Subsequently, salvage of residual tissue at the upper and lower tonsil pole with the raspa and careful hemostasis. Insertion of 2 hydrogen swabs and loosening of the oral retractor. After 5 minutes and if the mucosa is dry and there is no further bleeding, the procedure is completed. \ No newline at end of file diff --git a/483/InvasionFront_CD8_block6_x1_y11_patient483_0.json b/483/InvasionFront_CD8_block6_x1_y11_patient483_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b38d1acf8c159c2a2996c194bb3ccd1482d76c6 --- /dev/null +++ b/483/InvasionFront_CD8_block6_x1_y11_patient483_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 27410.5, + "Num Detections": 18715, + "Num Negative": 17935, + "Num Positive": 780, + "Positive %": 4.168, + "Num Positive per mm^2": 348.78 + } +} \ No newline at end of file diff --git a/483/InvasionFront_CD8_block6_x2_y11_patient483_1.json b/483/InvasionFront_CD8_block6_x2_y11_patient483_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3896d5ef70b3bb8a30f527fc6237d318ae5f0a11 --- /dev/null +++ b/483/InvasionFront_CD8_block6_x2_y11_patient483_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 27560.4, + "Num Detections": 18405, + "Num Negative": 17830, + "Num Positive": 575, + "Positive %": 3.124, + "Num Positive per mm^2": 248.34 + } +} \ No newline at end of file diff --git a/483/TumorCenter_CD3_block6_x1_y11_patient483_0.json b/483/TumorCenter_CD3_block6_x1_y11_patient483_0.json new file mode 100644 index 0000000000000000000000000000000000000000..77fdcc3dd424c0824662c0d9e88fa261f799eec8 --- /dev/null +++ b/483/TumorCenter_CD3_block6_x1_y11_patient483_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4197.8, + "Centroid Y µm": 28060.1, + "Num Detections": 19528, + "Num Negative": 18881, + "Num Positive": 647, + "Positive %": 3.313, + "Num Positive per mm^2": 286.89 + } +} \ No newline at end of file diff --git a/483/TumorCenter_CD3_block6_x2_y11_patient483_1.json b/483/TumorCenter_CD3_block6_x2_y11_patient483_1.json new file mode 100644 index 0000000000000000000000000000000000000000..211f7aae78210dbb930feed1001043cafa7f2698 --- /dev/null +++ b/483/TumorCenter_CD3_block6_x2_y11_patient483_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 28135.1, + "Num Detections": 10032, + "Num Negative": 9600, + "Num Positive": 432, + "Positive %": 4.306, + "Num Positive per mm^2": 327.86 + } +} \ No newline at end of file diff --git a/483/TumorCenter_CD8_block6_x1_y11_patient483_0.json b/483/TumorCenter_CD8_block6_x1_y11_patient483_0.json new file mode 100644 index 0000000000000000000000000000000000000000..df0d954f13a9e8cec83ce98be60e10e0a591d818 --- /dev/null +++ b/483/TumorCenter_CD8_block6_x1_y11_patient483_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 28559.9, + "Num Detections": 19428, + "Num Negative": 19133, + "Num Positive": 295, + "Positive %": 1.518, + "Num Positive per mm^2": 129.83 + } +} \ No newline at end of file diff --git a/483/TumorCenter_CD8_block6_x2_y11_patient483_1.json b/483/TumorCenter_CD8_block6_x2_y11_patient483_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b6197c48841627a60f4bcebb03b568e513399a73 --- /dev/null +++ b/483/TumorCenter_CD8_block6_x2_y11_patient483_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 28434.9, + "Num Detections": 15721, + "Num Negative": 15463, + "Num Positive": 258, + "Positive %": 1.641, + "Num Positive per mm^2": 126.42 + } +} \ No newline at end of file diff --git a/483/history_text.txt b/483/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..df27ab0d6ff44aac22d2872626ce725b08287000 --- /dev/null +++ b/483/history_text.txt @@ -0,0 +1 @@ +The patient has a cT4 cN2b hypopharyngeal carcinoma on the right. On CT, there is evidence of esophageal infiltration, a breakthrough through the thyroid cartilage is clearly visible, so that there is an indication for laryngectomy and probable partial pharyngectomy with flap plasty. \ No newline at end of file diff --git a/483/icd_codes.txt b/483/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..566ff193f6ccbe27d6e87e8c2f6ce9635a981eaa --- /dev/null +++ b/483/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, nicht näher bezeichnet[C32.9 ] \ No newline at end of file diff --git a/483/ops_codes.txt b/483/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7c53cda11c2156d168d8cf0d189fccdd34061829 --- /dev/null +++ b/483/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument[1-620.1 ] Diagnostische Ösophagoskopie: Mit starrem Instrument[1-630.1 ] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Laryngektomie: Mit Pharyngektomie und Schilddrüsenresektion: Rekonstruktion mit gestieltem Fernlappen[5-303.25 ] Pharyngoplastik: Mit gestieltem myokutanen Lappen[5-293.1 ] Plastische Rekonstruktion mit lokalen Lappen an Muskeln und Faszien: Myokutaner Lappen: Brustwand und Rücken[5-857.65 L] \ No newline at end of file diff --git a/483/patient_clinical_data.json b/483/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b5ec4ef8e1d68145d8ae07e35fcbde438903ed8e --- /dev/null +++ b/483/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 47, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 46, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/483/patient_pathological_data.json b/483/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f1f52787fe471204ba5f8e0845b018550ac92af2 --- /dev/null +++ b/483/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "483", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/483/surgery_description.txt b/483/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..cba9110f4d21e2628e66f05f16423d85c2a71475 --- /dev/null +++ b/483/surgery_description.txt @@ -0,0 +1 @@ +Neck revision with submandibulectomy diff --git a/483/surgery_report.txt b/483/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..62ba419bf780010a09b17891c3708fb4e1eb4320 --- /dev/null +++ b/483/surgery_report.txt @@ -0,0 +1 @@ +First head positioning. Pharyngoscopy after insertion of the mouthguard. An exophytic mass is seen starting at the entrance to the hypopharynx, growing into the endolarynx and affecting both sides of the glottic plane. Caudally, the tumor extends to the upper esophageal orifice. An infiltration cannot be ruled out with complete certainty after multiple diagnostic assessments and consultation with , but resection appears to be possible here. In summary of all findings, decision to proceed with curative surgical treatment. Skin disinfection without infiltration anesthesia in known CHD. Formation of an apron flap. Double ligation of the external jugular vein. Dissection with exposure of both submandibular glandulae. Rearrangement and neck dissection on the left side: Dissection of the sternocleidomastoid. Finding the accessorius nerve, which is spared in the further course. From caudal to cranial then development of the lateral neck preparation with removal of regions V, IV, III, II and Ib. The jugular vein, the accessorius nerve, the hypoglossal nerve, the superior thyroid artery and the carotid artery are freed from connective tissue structures and their course is visualized, identified and spared. The superior thyroid artery is dissected after its caudal exit, doped and stitched. The superior laryngeal nerve is also identified as it enters the larynx together with the accompanying vessels and removed. Now mobilize the lateral laryngeal skeleton. Separate the infralaryngeal muscles and strike downwards. Mobilization of the left thyroid pole from the laryngeal skeleton, beating laterally after separation and ligation of the isthmus. Exposure of the left-sided hyoid bone. Exposure of the posterior border of the thyroid cartilage and the upper edge of the thyroid cartilage as well as the superior cornu. This is exposed and the constrictor, already pushed off on the inside, in preparation for the laryngectomy step. Transfer to the opposite side after hemostasis. Identical procedure on the right side. Identification of the sternocleidomastoid muscle and the accessorius nerve. Protection of both structures during the procedure. The vascular sheath and the internal jugular vein and the common carotid artery are also shown here. Cranial placement of the borders with identification of the digastric muscle through the apron flap. Dissection from caudal to cranial in levels V, IV and III. It can now be seen that a metastatic conglomerate of 3 nodes is located in the jugulofacial angle on the internal jugular vein and appears to infiltrate it. It is not possible to dissect the conglomerate from the vein sharply or bluntly without risking a lesion. Therefore, cranially locate the end of the vein and caudally remove the conglomerate after double ligation and repositioning. Identification of the hypoglossal nerve. This is also spared in the further course. Completion of the neck in levels II and III and ventral removal of connective tissue. The infralaryngeal musculature is not removed here, as infiltration by underlying tumor parts cannot be ruled out. Dissection of the carotid and residual venous parts as well as the vagus nerve, which are folded further laterally and spared, and mobilization of the constrictor muscles caudally. Now repositioning for tracheotomy. Exposure of the surgical site caudally. Insertion into the trachea between the 1st and 2nd tracheal clasp. Placement of 2 holding sutures. Further mobilization of the left thyroid lobe caudally and mobilization of the laryngeal preparation from the left and right. For this purpose, also identify the right-sided hyoid bone parts and separate them sharply with the electric knife. Also on the right side, attempt to expose the cornu superius of the upper edge of the thyroid cartilage, but this is not done due to the large tumor so as not to open the tumor. In the median plane, entry into the pre-epiglottic fatty tissue. Identification of the epiglottis and disluxation with the tumor grasping forceps. Now, starting from the healthy side, release the laryngectomy specimen from cranial to caudal with the right-sided hypopharyngeal carcinoma inside. Under visualization and leaving a macroscopically healthy mucosa and muscle layer, consecutive removal under bipolar coagulation. The specimen is submitted as a whole for frozen section and R0 diagnosis. The specimen grows to the left side before entering the upper esophageal sphincter, so that only a small pharyngeal tube remains here. According to from the pathology department, parts of a carcinoma in situ are still found at the lateral central resection margin, so that 2 resections are taken here as a margin sample. As further resection is not possible under any circumstances, we do not wait for a frozen section diagnosis, but continue with the operation and send the samples for urgent histological processing. The decision is now made to cover the defect using a pectoralis major flap: Marking of the blood vessel supply and the medially overlying skin island, which is measured beforehand. First incision at the lateral edge of the pectoralis major and identification of the supplying arterial areas. Then cut around the skin area caudally. Adaptation with Vicryl sutures of the flap epithelium with the muscle. Mobilization of a tunnel and connection to the neck access under constant view of the supplying artery. Fluxing through the flap and now double-layer inverted suturing of the flap and the resection area at all points. A T-shaped suture is first created at the base of the tongue to enable tension-free suturing. The remaining adaptation is now very successful. In the cranial area towards the base of the tongue, a third row of sutures for complete wound closure. Now complete the tracheostoma suture using Ethibond. Two-layer wound closure after placement of Redon drains in the flap removal area. Two-layer wound closure on both cervical sides after placement of 2 Redon drains. On the right cervical side in the area of the flap pedicle, the skin is not closed in order to avoid compression of the feeding vessels. Lomatuell is applied here. The patient received Unacid 3 g every 8 hours intraoperatively; this should be continued for 5 days. As far as swallowing function is concerned, with subsequent radiotherapy, complaints are certainly to be expected in the context of this maximum reconstruction. The gastric tube should be removed between the 7th and 10th postoperative day after an X-ray pre-swallow. In any case, postoperative radiotherapy if borderline in sano resection is possible at all. Voice rehabilitation can be attempted by means of ructus, but here too the chances of success are rather critical. Termination of the operation. \ No newline at end of file diff --git a/484/InvasionFront_CD3_block22_x5_y11_patient484_0.json b/484/InvasionFront_CD3_block22_x5_y11_patient484_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b76dc3f2c95ba3f6ce01cbd062763beb74f87e24 --- /dev/null +++ b/484/InvasionFront_CD3_block22_x5_y11_patient484_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16666.2, + "Centroid Y µm": 39154.3, + "Num Detections": 33282, + "Num Negative": 29970, + "Num Positive": 3312, + "Positive %": 9.951, + "Num Positive per mm^2": 1124.1 + } +} \ No newline at end of file diff --git a/484/InvasionFront_CD3_block22_x6_y11_patient484_1.json b/484/InvasionFront_CD3_block22_x6_y11_patient484_1.json new file mode 100644 index 0000000000000000000000000000000000000000..974ab8a373d8d990f2b84bc1578c62acdc71d75c --- /dev/null +++ b/484/InvasionFront_CD3_block22_x6_y11_patient484_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19139.9, + "Centroid Y µm": 39229.2, + "Num Detections": 28976, + "Num Negative": 27307, + "Num Positive": 1669, + "Positive %": 5.76, + "Num Positive per mm^2": 607.35 + } +} \ No newline at end of file diff --git a/484/InvasionFront_CD8_block22_x5_y11_patient484_0.json b/484/InvasionFront_CD8_block22_x5_y11_patient484_0.json new file mode 100644 index 0000000000000000000000000000000000000000..92226c685ce5c13a354b961198d8ca87a0471293 --- /dev/null +++ b/484/InvasionFront_CD8_block22_x5_y11_patient484_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19464.7, + "Centroid Y µm": 26960.7, + "Num Detections": 32787, + "Num Negative": 30491, + "Num Positive": 2296, + "Positive %": 7.003, + "Num Positive per mm^2": 795.98 + } +} \ No newline at end of file diff --git a/484/InvasionFront_CD8_block22_x6_y11_patient484_1.json b/484/InvasionFront_CD8_block22_x6_y11_patient484_1.json new file mode 100644 index 0000000000000000000000000000000000000000..881d0401b8661c1f0df730cf09446842ba44e158 --- /dev/null +++ b/484/InvasionFront_CD8_block22_x6_y11_patient484_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21863.4, + "Centroid Y µm": 26985.7, + "Num Detections": 27907, + "Num Negative": 27462, + "Num Positive": 445, + "Positive %": 1.595, + "Num Positive per mm^2": 165.14 + } +} \ No newline at end of file diff --git a/484/TumorCenter_CD3_block22_x5_y11_patient484_0.json b/484/TumorCenter_CD3_block22_x5_y11_patient484_0.json new file mode 100644 index 0000000000000000000000000000000000000000..afc3ef7cd0449d2bf7607a2a51be69636d788ba3 --- /dev/null +++ b/484/TumorCenter_CD3_block22_x5_y11_patient484_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15929.1, + "Centroid Y µm": 27835.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/484/TumorCenter_CD3_block22_x6_y11_patient484_1.json b/484/TumorCenter_CD3_block22_x6_y11_patient484_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b27566494eec56b65cffad94229c6e855098a5b3 --- /dev/null +++ b/484/TumorCenter_CD3_block22_x6_y11_patient484_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 27810.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/484/TumorCenter_CD8_block22_x5_y11_patient484_0.json b/484/TumorCenter_CD8_block22_x5_y11_patient484_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2468379ba453eecd516800e9519b5e66a3f174de --- /dev/null +++ b/484/TumorCenter_CD8_block22_x5_y11_patient484_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18233.2, + "Centroid Y µm": 37950.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/484/TumorCenter_CD8_block22_x6_y11_patient484_1.json b/484/TumorCenter_CD8_block22_x6_y11_patient484_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5436d6f2a62d3605c4fe4f01a5cf89ebbc6725d3 --- /dev/null +++ b/484/TumorCenter_CD8_block22_x6_y11_patient484_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20676.0, + "Centroid Y µm": 37977.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/484/history_text.txt b/484/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/484/icd_codes.txt b/484/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7c51df154e1def72da62b6657df309acd9ab8d5 --- /dev/null +++ b/484/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Bösartige Neubildung der Seitenwand des Oropharynx[C10.2 ] \ No newline at end of file diff --git a/484/ops_codes.txt b/484/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..726726467ee7f590e847e7fdcfd258c61397247f --- /dev/null +++ b/484/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.01 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/484/patient_clinical_data.json b/484/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..051fbab0703470b2e00ef21d37104e9d6496cba0 --- /dev/null +++ b/484/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/484/patient_pathological_data.json b/484/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e2d7ec12d4fa6dd8a746b1ba6a7e3ef90399c4b4 --- /dev/null +++ b/484/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "484", + "primary_tumor_site": "CUP", + "pT_stage": "TX", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 6.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/484/surgery_description.txt b/484/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4a3cc42c2635da5b434222522633b0a50b4ca827 --- /dev/null +++ b/484/surgery_description.txt @@ -0,0 +1 @@ +Transoral, robot-assisted resection, and Tracheotomy diff --git a/484/surgery_report.txt b/484/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a72face8c80297470f2692521c2a6fc1d43a56f0 --- /dev/null +++ b/484/surgery_report.txt @@ -0,0 +1 @@ +First, a panendoscopy is performed. This reveals a tumor of the left anterior palatal arch, the tonsil, which then extends over the vallecula to the hypopharynx. However, the piriform sinus of the left side is completely omitted by the tumor. The same applies to the entire right side of the hypopharynx and oropharynx. The tumor certainly does not reach the midline of the soft palate. From the tonsil, the tumor passes slightly onto the glossotonsillar groove. First adjust and expose the tumor with the FK retractor. Then start resection at the anterior palatal arch. From here, dissection down to the tonsil, which is then resected with tissue surrounding the tonsil capsule in the sense of a tumor tonsillectomy. The pharyngeal musculature is exposed. There is no evidence of deep tumor growth. The tumor is then developed further caudally. Here resection of the glossotonsillar groove with transition of the resection to the base of the tongue. A part of the base of the tongue is also resected here. Further dissection then caudally, towards the hypopharynx, where the tumor can then be safely removed at the entrance to the piriform sinus. Now take samples from the margins at the entrance to the piriform sinus, the anterior and posterior margins and the base of the tongue. It then becomes apparent that the tumor reaches the lingual epiglottis via the vallecula, so that a corresponding part of the lingual epiglottis is resected here as well. Now also take a marginal sample at the resection margin of the epiglottis. The area of the entrance of the piriform sinus at the front and at the epiglottis is then assessed by the pathologist as a carcinoma in situ in the frozen section, so that another resection is performed here. A resection is then performed on the epiglottis and the anterior piriform sinus entrance. If the mucosal aspect is absolutely inconspicuous macroscopically, the corresponding marginal samples are taken again from the epiglottis and the anterior piriform sinus entrance. When the marginal sample is taken, there is a somewhat heavier bleeding here from the depths, which can only be controlled with difficulty using monopolar coagulation. The area of the resection site can now hardly be exposed with the FK retractor, so that it is then decided not to carry out any further resection in depth, regardless of the result of the histological findings of the frozen section examination. If the wound is dry, all instruments are then removed. Then reposition the patient by tracheotomy. Perform a pretracheal transverse incision and then dissect in layers in depth. Exposure of the thyroid isthmus. Then separate the infrahyoid and infralaryngeal muscles at the midline. Clamping of the thyroid isthmus and separation of the thyroid muscle as well as bilateral repositioning. Then expose the anterior surface of the trachea, open the trachea between the 2nd and 3rd cartilage clasp, prepare a Björk flap and then suture the tracheostoma in a circular fashion, followed by reintubation onto an 8-gauge cannula. The intraoperative frozen section at the epiglottis is then assessed as tumor-free. The frozen section in the area of the resection site on the piriform sinus on the anterior wall is again described as carcinoma in situ. However, since a left neck dissection is required anyway in this patient with a positive lymph node status on the left side of the neck, another transoral laser resection should be performed in the area of the piriform sinus anterior wall on the left side in connection with this procedure. The procedure is therefore completed at this point. After extubation, the patient returns to the normal ward of the ENT clinic. \ No newline at end of file diff --git a/485/InvasionFront_CD3_block20_x1_y6_patient485_0.json b/485/InvasionFront_CD3_block20_x1_y6_patient485_0.json new file mode 100644 index 0000000000000000000000000000000000000000..939cb624ca0fd3e6a7bd5c18623098c764bb2870 --- /dev/null +++ b/485/InvasionFront_CD3_block20_x1_y6_patient485_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4972.4, + "Centroid Y µm": 14442.4, + "Num Detections": 23408, + "Num Negative": 21166, + "Num Positive": 2242, + "Positive %": 9.578, + "Num Positive per mm^2": 818.93 + } +} \ No newline at end of file diff --git a/485/InvasionFront_CD3_block20_x2_y6_patient485_1.json b/485/InvasionFront_CD3_block20_x2_y6_patient485_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7cf2d022c4d7a218a6787ac9b8ab5e50af6b3ecc --- /dev/null +++ b/485/InvasionFront_CD3_block20_x2_y6_patient485_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7546.0, + "Centroid Y µm": 14567.3, + "Num Detections": 24923, + "Num Negative": 23354, + "Num Positive": 1569, + "Positive %": 6.295, + "Num Positive per mm^2": 573.45 + } +} \ No newline at end of file diff --git a/485/InvasionFront_CD8_block20_x1_y6_patient485_0.json b/485/InvasionFront_CD8_block20_x1_y6_patient485_0.json new file mode 100644 index 0000000000000000000000000000000000000000..55bea12e64c99575bd6ad77cd7f8ef8fe9375fea --- /dev/null +++ b/485/InvasionFront_CD8_block20_x1_y6_patient485_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4522.6, + "Centroid Y µm": 15716.7, + "Num Detections": 23455, + "Num Negative": 23162, + "Num Positive": 293, + "Positive %": 1.249, + "Num Positive per mm^2": 109.35 + } +} \ No newline at end of file diff --git a/485/InvasionFront_CD8_block20_x2_y6_patient485_1.json b/485/InvasionFront_CD8_block20_x2_y6_patient485_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9d3e4354220dc5586c2bcd6453260475fa6d3218 --- /dev/null +++ b/485/InvasionFront_CD8_block20_x2_y6_patient485_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 15516.8, + "Num Detections": 24746, + "Num Negative": 24226, + "Num Positive": 520, + "Positive %": 2.101, + "Num Positive per mm^2": 193.95 + } +} \ No newline at end of file diff --git a/485/TumorCenter_CD3_block20_x1_y6_patient485_0.json b/485/TumorCenter_CD3_block20_x1_y6_patient485_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d41d737c9d9805df060f3a66de2e3cca501fe23 --- /dev/null +++ b/485/TumorCenter_CD3_block20_x1_y6_patient485_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3662.3, + "Centroid Y µm": 14314.2, + "Num Detections": 17740, + "Num Negative": 15996, + "Num Positive": 1744, + "Positive %": 9.831, + "Num Positive per mm^2": 695.69 + } +} \ No newline at end of file diff --git a/485/TumorCenter_CD3_block20_x2_y6_patient485_1.json b/485/TumorCenter_CD3_block20_x2_y6_patient485_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c978ac5d668ae9364098d66c49792dbb55f171cc --- /dev/null +++ b/485/TumorCenter_CD3_block20_x2_y6_patient485_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6245.0, + "Centroid Y µm": 14354.6, + "Num Detections": 23196, + "Num Negative": 22661, + "Num Positive": 535, + "Positive %": 2.306, + "Num Positive per mm^2": 196.7 + } +} \ No newline at end of file diff --git a/485/TumorCenter_CD8_block20_x1_y6_patient485_0.json b/485/TumorCenter_CD8_block20_x1_y6_patient485_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0c1973f8bbd118146c2857b13ac07ac4eae89574 --- /dev/null +++ b/485/TumorCenter_CD8_block20_x1_y6_patient485_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3298.3, + "Centroid Y µm": 15391.9, + "Num Detections": 19325, + "Num Negative": 18173, + "Num Positive": 1152, + "Positive %": 5.961, + "Num Positive per mm^2": 516.21 + } +} \ No newline at end of file diff --git a/485/TumorCenter_CD8_block20_x2_y6_patient485_1.json b/485/TumorCenter_CD8_block20_x2_y6_patient485_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ed46b21e08442b7f76356caf72aec0a70fbe8e65 --- /dev/null +++ b/485/TumorCenter_CD8_block20_x2_y6_patient485_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5971.8, + "Centroid Y µm": 15241.9, + "Num Detections": 25423, + "Num Negative": 23979, + "Num Positive": 1444, + "Positive %": 5.68, + "Num Positive per mm^2": 537.79 + } +} \ No newline at end of file diff --git a/485/history_text.txt b/485/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..969671a6ed52fcaf37936bee1204816b8795952b --- /dev/null +++ b/485/history_text.txt @@ -0,0 +1 @@ +In the patient, a moderately differentiated squamous cell carcinoma was histologically confirmed during a panendoscopy in the right glottis area. Intraoperative cT1a extension with questionable transition to the supraglottis. No clearly definable tumor on computed tomography, certainly no cartilage erosion or infiltration. In our interdisciplinary tumor conference, primary surgical treatment was decided. \ No newline at end of file diff --git a/485/icd_codes.txt b/485/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/485/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/485/ops_codes.txt b/485/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..691bf00e37115c2eb939df612fea5288c9faccdc --- /dev/null +++ b/485/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Mikrolaryngoskopie[1-610.2 ] Mikrolaryngoskopie mit Resektion eines Stimmbandtumors[5-300.5 ] Endoskopische Laserresektion am Larynx[5-302.5 ] \ No newline at end of file diff --git a/485/patient_clinical_data.json b/485/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b090e689be5bd11678f84ff38ae2900d4db0904c --- /dev/null +++ b/485/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/485/patient_pathological_data.json b/485/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9db9f3523908226f3063a80744d9e896ed1800be --- /dev/null +++ b/485/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "485", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/485/surgery_description.txt b/485/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..994a8f5b8155bee125c408514fd7a3ac598a1b6a --- /dev/null +++ b/485/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection, Microlaryngoscopy diff --git a/485/surgery_report.txt b/485/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2cc0f5a91ddcbc1bbddffc0bd410b319f8348b87 --- /dev/null +++ b/485/surgery_report.txt @@ -0,0 +1 @@ +After induction and intubation by the anesthesia colleagues, the Kleinsasser tube is inserted under dental protection after inspection of the inconspicuous oral vestibule. The oral cavity and pharynx are then inspected and found to be normal. Adjustment of the endolarynx with the aid of the surgical microscope. An exophytic, partially ulcerated tumor is seen in the area of the glottis on the right, which grows almost along the entire length of the vocal fold on the right side, the anterior commissure is free. Adherence in the area of the posterior commissure towards Ary, but without further signs of infiltration here. The tumor grows clearly laterally, infiltrates and partially consumes the pocket fold. The ventriculus laryngis is used up. However, the tumor can still be displaced over the fold of the larynx by palpation. Demonstration of findings on and confirmation of the primary surgical procedure. Resection is now performed with the 2-5 Watt laser. Inclusion of the pocket fold, which is almost completely resected, allowing the tumor, which clearly infiltrates the ventriculis laryngis in depth, to be resected in sano. Subtotal resection of the paralaryngeal musculature. Finally, healthy conditions on all sides in depth. Separation in the area of the anterior commissure, leaving a minimal residual vocal fold anteriorly on the right. Dorsal resection including the vocal process. The tumor is attached to the vocal process. However, complete mobilization and exclusion of further arytenoid infiltration by resection of the processus. Removal of the tumor in toto. Careful hemostasis. Subsequent representative marginal sampling in all planes, especially in the paraglottic direction and in the area of the arytenoid. All marginal samples are free of dysplasia and tumors in the frozen section diagnostics, so that an R0 situation can be assumed here. Final inspection and with absolutely dry and slim glottic conditions, the procedure was completed without any indication of complications. Conclusion: Intraoperatively R0 resected cT2 glottic carcinoma on the right. After receiving the definitive histology, discussion of the adjuvant therapy options, also with regard to the extension with infiltration of the pocket fold, in our interdisciplinary tumor conference and if no further measures are taken, a control microlaryngoscopy should be performed in approx. 8 weeks. \ No newline at end of file diff --git a/486/InvasionFront_CD3_block15_x3_y12_patient486_0.json b/486/InvasionFront_CD3_block15_x3_y12_patient486_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a684d4ee50843b08e0f6a359cef41c32542c5d27 --- /dev/null +++ b/486/InvasionFront_CD3_block15_x3_y12_patient486_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14217.5, + "Centroid Y µm": 39654.0, + "Num Detections": 8489, + "Num Negative": 8298, + "Num Positive": 191, + "Positive %": 2.25, + "Num Positive per mm^2": 169.16 + } +} \ No newline at end of file diff --git a/486/InvasionFront_CD3_block15_x4_y12_patient486_1.json b/486/InvasionFront_CD3_block15_x4_y12_patient486_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b7244a80a5db2e6dbe519b425b0ee4b3571664c6 --- /dev/null +++ b/486/InvasionFront_CD3_block15_x4_y12_patient486_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16947.8, + "Centroid Y µm": 39846.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/486/InvasionFront_CD8_block15_x3_y12_patient486_0.json b/486/InvasionFront_CD8_block15_x3_y12_patient486_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b5abd59798cfe71e312d52714b6676e38c6f29dd --- /dev/null +++ b/486/InvasionFront_CD8_block15_x3_y12_patient486_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11730.2, + "Centroid Y µm": 29141.7, + "Num Detections": 6436, + "Num Negative": 6044, + "Num Positive": 392, + "Positive %": 6.091, + "Num Positive per mm^2": 496.33 + } +} \ No newline at end of file diff --git a/486/InvasionFront_CD8_block15_x4_y12_patient486_1.json b/486/InvasionFront_CD8_block15_x4_y12_patient486_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4bb90b41dfecd8d4a24ea95b9ee3b547f2f496eb --- /dev/null +++ b/486/InvasionFront_CD8_block15_x4_y12_patient486_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14299.1, + "Centroid Y µm": 29020.7, + "Num Detections": 8169, + "Num Negative": 8058, + "Num Positive": 111, + "Positive %": 1.359, + "Num Positive per mm^2": 65.99 + } +} \ No newline at end of file diff --git a/486/TumorCenter_CD3_block15_x3_y12_patient486_0.json b/486/TumorCenter_CD3_block15_x3_y12_patient486_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bbd2cf519d5c424d0fa5f69c125fa73c2604370a --- /dev/null +++ b/486/TumorCenter_CD3_block15_x3_y12_patient486_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 33282.4, + "Num Detections": 15849, + "Num Negative": 15600, + "Num Positive": 249, + "Positive %": 1.571, + "Num Positive per mm^2": 110.63 + } +} \ No newline at end of file diff --git a/486/TumorCenter_CD3_block15_x4_y12_patient486_1.json b/486/TumorCenter_CD3_block15_x4_y12_patient486_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f7d2e4803a81a022952ee78a31d32927a036207 --- /dev/null +++ b/486/TumorCenter_CD3_block15_x4_y12_patient486_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 33407.3, + "Num Detections": 19941, + "Num Negative": 19284, + "Num Positive": 657, + "Positive %": 3.295, + "Num Positive per mm^2": 281.85 + } +} \ No newline at end of file diff --git a/486/TumorCenter_CD8_block15_x3_y12_patient486_0.json b/486/TumorCenter_CD8_block15_x3_y12_patient486_0.json new file mode 100644 index 0000000000000000000000000000000000000000..18e86d83d0f4d653146603f8e002e13c97df7b01 --- /dev/null +++ b/486/TumorCenter_CD8_block15_x3_y12_patient486_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 29809.2, + "Num Detections": 18978, + "Num Negative": 18388, + "Num Positive": 590, + "Positive %": 3.109, + "Num Positive per mm^2": 265.73 + } +} \ No newline at end of file diff --git a/486/TumorCenter_CD8_block15_x4_y12_patient486_1.json b/486/TumorCenter_CD8_block15_x4_y12_patient486_1.json new file mode 100644 index 0000000000000000000000000000000000000000..743a298a85134d9e2874b22c2cda222c2011392a --- /dev/null +++ b/486/TumorCenter_CD8_block15_x4_y12_patient486_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16116.5, + "Centroid Y µm": 29809.2, + "Num Detections": 19734, + "Num Negative": 18596, + "Num Positive": 1138, + "Positive %": 5.767, + "Num Positive per mm^2": 489.42 + } +} \ No newline at end of file diff --git a/486/history_text.txt b/486/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..410cbd110da2216fbf94a40f9df72f5375563a2e --- /dev/null +++ b/486/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma on the left edge of the tongue cT1. The above procedure was therefore indicated. \ No newline at end of file diff --git a/486/icd_codes.txt b/486/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/486/ops_codes.txt b/486/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/486/patient_clinical_data.json b/486/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bf91e6c82ff4dd9d0e71cc49dc5f681522337b00 --- /dev/null +++ b/486/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 67, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/486/patient_pathological_data.json b/486/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4fa76faffcd4c8be6e43e1a46f701aadfd5696e1 --- /dev/null +++ b/486/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "486", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 12, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/486/surgery_description.txt b/486/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..13b11d7eb0cacf8f4b401fdacc820da2dc51a9bb --- /dev/null +++ b/486/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Resection of left tongue margin diff --git a/486/surgery_report.txt b/486/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d2aae5467a1f1697bd03ab5934b45c883df85576 --- /dev/null +++ b/486/surgery_report.txt @@ -0,0 +1 @@ +First tracheoscopy: Unremarkable mucosal conditions on all sides up to the carina. Then MLE: Mucosal conditions in the larynx unremarkable on all sides. Oro-/hypopharyngoscopy: Mucosal conditions in the hypo- and oropharynx unremarkable on all sides, esophageal entrance clear. Tonsil lobe and tongue base free on inspection and palpation. In the area of the vallecula, a cyst of approx. 1.5 cm in size is visible; this is unroofed and a creamy secretion is discharged. Flexible esophagoscopy: Advancement of the esophagoscope into the stomach. No abnormalities on gross examination. No evidence of a second tumor was found in the entire esophageal area on retraction. Then repositioning for tumor resection: holding suture on the tongue. Insertion of a blocker. The tongue margin tumor is seen on the left. This was incised on all sides with a safety margin of 1 cm. The mucosa can be seen medially, which appears somewhat roughened. A resection is therefore performed again. In addition, a medial margin sample was taken. Dorsal to the tumor, there is also a change suspicious of leukoplakia, which cannot be clearly distinguished from tumor growth. Here too, the entire altered area is resected in toto. Both tumor specimens, as well as the marginal specimen, are sent for histology with a thread marker. No evidence of tumor at the tumor margins or in the margin specimen in the frozen section. Therefore R0 resection. Subsequent careful hemostasis and adaptive Vicryl 3/0 single button sutures on the left tongue margin. The procedure was completed without complications. \ No newline at end of file diff --git a/487/InvasionFront_CD3_block6_x1_y9_patient487_0.json b/487/InvasionFront_CD3_block6_x1_y9_patient487_0.json new file mode 100644 index 0000000000000000000000000000000000000000..93c7f66d197c3663bf65be8a1047b5c5115a3933 --- /dev/null +++ b/487/InvasionFront_CD3_block6_x1_y9_patient487_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 23012.8, + "Num Detections": 23394, + "Num Negative": 15221, + "Num Positive": 8173, + "Positive %": 34.94, + "Num Positive per mm^2": 2979.2 + } +} \ No newline at end of file diff --git a/487/InvasionFront_CD3_block6_x2_y9_patient487_1.json b/487/InvasionFront_CD3_block6_x2_y9_patient487_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f62c0af1062d378dba56add66f1330a9fcae93ed --- /dev/null +++ b/487/InvasionFront_CD3_block6_x2_y9_patient487_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6771.4, + "Centroid Y µm": 23062.8, + "Num Detections": 28216, + "Num Negative": 20603, + "Num Positive": 7613, + "Positive %": 26.98, + "Num Positive per mm^2": 2529.7 + } +} \ No newline at end of file diff --git a/487/InvasionFront_CD8_block6_x1_y7_patient487_0.json b/487/InvasionFront_CD8_block6_x1_y7_patient487_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0edfda08906341917e86366d34072e7e5be3a42b --- /dev/null +++ b/487/InvasionFront_CD8_block6_x1_y7_patient487_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4497.6, + "Centroid Y µm": 17091.0, + "Num Detections": 8150, + "Num Negative": 7993, + "Num Positive": 157, + "Positive %": 1.926, + "Num Positive per mm^2": 168.0 + } +} \ No newline at end of file diff --git a/487/InvasionFront_CD8_block6_x2_y7_patient487_1.json b/487/InvasionFront_CD8_block6_x2_y7_patient487_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fabfa7671b95ccbe6ae8f97f715c1efd4e4333e5 --- /dev/null +++ b/487/InvasionFront_CD8_block6_x2_y7_patient487_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7196.2, + "Centroid Y µm": 17265.9, + "Num Detections": 19782, + "Num Negative": 19401, + "Num Positive": 381, + "Positive %": 1.926, + "Num Positive per mm^2": 168.16 + } +} \ No newline at end of file diff --git a/487/TumorCenter_CD3_block6_x1_y7_patient487_0.json b/487/TumorCenter_CD3_block6_x1_y7_patient487_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3bcbd284a7ceffda6da67da68a036b3020ba7339 --- /dev/null +++ b/487/TumorCenter_CD3_block6_x1_y7_patient487_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 18090.4, + "Num Detections": 22941, + "Num Negative": 21931, + "Num Positive": 1010, + "Positive %": 4.403, + "Num Positive per mm^2": 374.64 + } +} \ No newline at end of file diff --git a/487/TumorCenter_CD3_block6_x2_y7_patient487_1.json b/487/TumorCenter_CD3_block6_x2_y7_patient487_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f94cf0f2ce910617de907a16e814897061594e5f --- /dev/null +++ b/487/TumorCenter_CD3_block6_x2_y7_patient487_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 18090.4, + "Num Detections": 12843, + "Num Negative": 12007, + "Num Positive": 836, + "Positive %": 6.509, + "Num Positive per mm^2": 575.41 + } +} \ No newline at end of file diff --git a/487/TumorCenter_CD8_block6_x1_y7_patient487_0.json b/487/TumorCenter_CD8_block6_x1_y7_patient487_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f0f84b428cafb8414d347d1215f17d4fc54c474 --- /dev/null +++ b/487/TumorCenter_CD8_block6_x1_y7_patient487_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3798.0, + "Centroid Y µm": 18415.2, + "Num Detections": 24279, + "Num Negative": 24163, + "Num Positive": 116, + "Positive %": 0.4778, + "Num Positive per mm^2": 43.44 + } +} \ No newline at end of file diff --git a/487/TumorCenter_CD8_block6_x2_y7_patient487_1.json b/487/TumorCenter_CD8_block6_x2_y7_patient487_1.json new file mode 100644 index 0000000000000000000000000000000000000000..20898feb79680d9942517cc2a0bff909e5ce6df3 --- /dev/null +++ b/487/TumorCenter_CD8_block6_x2_y7_patient487_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 18315.3, + "Num Detections": 24222, + "Num Negative": 24072, + "Num Positive": 150, + "Positive %": 0.6193, + "Num Positive per mm^2": 57.02 + } +} \ No newline at end of file diff --git a/487/history_text.txt b/487/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/487/icd_codes.txt b/487/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45f3b11d417640902db29970effb5fc452958a4b --- /dev/null +++ b/487/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Seitenwand des Oropharynx[C10.2 L] Unsichere Neubildung der Stimmbänder[D38.0 ] \ No newline at end of file diff --git a/487/ops_codes.txt b/487/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4699a17478da5ace38b281fc20fdfc3dc87464f3 --- /dev/null +++ b/487/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision Lippe[5-273.5 ] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Mikrolaryngoskopie mit Resektion eines Stimmbandtumors[5-300.5 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] \ No newline at end of file diff --git a/487/patient_clinical_data.json b/487/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f99ed68ddcb35567d23aab2ef8ce6c54ef6a7dbd --- /dev/null +++ b/487/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/487/patient_pathological_data.json b/487/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..66264949caaf660edb81c6c4b52d436d6ed7a9e4 --- /dev/null +++ b/487/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "487", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/487/surgery_description.txt b/487/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ab6802cce3ba6d869b2571e7fced1445d1df0d69 --- /dev/null +++ b/487/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy, Panendoscopy diff --git a/487/surgery_report.txt b/487/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..38be3d5133a37a1419ef7c99ce281cbbbb88ca13 --- /dev/null +++ b/487/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carrying out the team time-out. Introductory consultation with anesthesia colleagues. Induction of anesthesia. Transition to rigid tracheoscopy. Passing the glottis and entering endotracheally. Mucosal conditions are unremarkable on all sides up to the exit of the segmental bronchi. Withdrawal of the endoscope and subsequent intubation of the patient. Fixation of the tube. Transition to esophagogastroscopy. Move the flexible endoscope into the stomach under visualization with constant air insufflation. An uneven mucosal relief can be seen in the area of the cardia; this should also be assessed gastroenterologically at intervals. After desufflation, slowly withdraw the endoscope with circular inspection of all esophageal sections. Inconspicuous conditions here. Remove the endoscope. Proceed to laryngoscopy. First position the patient in head reclination. Insertion of the mouth guard. Enter with the Kleinsasser tube. With the aid of the support autoscopy and the surgical microscope, an extensive leukoplakic change of the entire left vocal fold is revealed. A microlaryngoscopically controlled decortication of the left vocal fold from the vocal process to the anterior commissure is now performed. The preparation is sent for histological processing. Hemostasis by insertion of a suprarenin-soaked laryngeal swab. Final inspection of the piriform sinus on both sides and the postcricoid region. Inconspicuous conditions here. The same applies to the supraglottic region and the vallecula. In the region of the oropharynx, there is an apparently superficially growing, highly suspicious change on the left side. This extends from the anterior palatal arch over the glossotonsillar groove to the alveolar ridge of the last molar. Palpatory superficial growth. The tumor is now resected transorally in the sense of an outgoing excision biopsy. Circular marginal samples are also taken. Hemostasis by means of bipolar coagulation. Dry wound bed at the end of the operation. Final consultation with the anesthesia colleagues and completion of the operation without complications. Note: Extensive leukoplakia in the area of the left vocal fold. In addition, oropharyngeal carcinoma on the left, which was resected transorally in the sense of an extended excision biopsy. In addition, intraoperative esophagogastroscopy revealed a finding in the area of the gastroesophageal junction that was worth checking. This should be promptly assessed by the gastroenterology colleagues. \ No newline at end of file diff --git a/488/InvasionFront_CD3_block12_x5_y4_patient488_0.json b/488/InvasionFront_CD3_block12_x5_y4_patient488_0.json new file mode 100644 index 0000000000000000000000000000000000000000..66df494d6bf15ea744a4f5678b01be4d8c1fcea7 --- /dev/null +++ b/488/InvasionFront_CD3_block12_x5_y4_patient488_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16941.0, + "Centroid Y µm": 15017.0, + "Num Detections": 19106, + "Num Negative": 18635, + "Num Positive": 471, + "Positive %": 2.465, + "Num Positive per mm^2": 196.21 + } +} \ No newline at end of file diff --git a/488/InvasionFront_CD3_block12_x6_y4_patient488_1.json b/488/InvasionFront_CD3_block12_x6_y4_patient488_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8053d89139a8fcd568bf0a830b93e5b5faa95b3f --- /dev/null +++ b/488/InvasionFront_CD3_block12_x6_y4_patient488_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19439.7, + "Centroid Y µm": 15341.9, + "Num Detections": 14976, + "Num Negative": 14904, + "Num Positive": 72, + "Positive %": 0.4808, + "Num Positive per mm^2": 38.28 + } +} \ No newline at end of file diff --git a/488/InvasionFront_CD8_block12_x5_y4_patient488_0.json b/488/InvasionFront_CD8_block12_x5_y4_patient488_0.json new file mode 100644 index 0000000000000000000000000000000000000000..509155b75a947ff4e36e796a2a90f9663d7b61a5 --- /dev/null +++ b/488/InvasionFront_CD8_block12_x5_y4_patient488_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17091.0, + "Centroid Y µm": 13392.9, + "Num Detections": 13293, + "Num Negative": 13010, + "Num Positive": 283, + "Positive %": 2.129, + "Num Positive per mm^2": 183.49 + } +} \ No newline at end of file diff --git a/488/InvasionFront_CD8_block12_x6_y4_patient488_1.json b/488/InvasionFront_CD8_block12_x6_y4_patient488_1.json new file mode 100644 index 0000000000000000000000000000000000000000..93092ae605c9af1d03e0e1a876f31e8f5e0698c6 --- /dev/null +++ b/488/InvasionFront_CD8_block12_x6_y4_patient488_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19639.6, + "Centroid Y µm": 13268.0, + "Num Detections": 16680, + "Num Negative": 16607, + "Num Positive": 73, + "Positive %": 0.4376, + "Num Positive per mm^2": 36.65 + } +} \ No newline at end of file diff --git a/488/TumorCenter_CD3_block12_x5_y4_patient488_0.json b/488/TumorCenter_CD3_block12_x5_y4_patient488_0.json new file mode 100644 index 0000000000000000000000000000000000000000..826b97379925c5b0cfe9987d06f0bebdfb0e8a0d --- /dev/null +++ b/488/TumorCenter_CD3_block12_x5_y4_patient488_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 9894.8, + "Num Detections": 15682, + "Num Negative": 15355, + "Num Positive": 327, + "Positive %": 2.085, + "Num Positive per mm^2": 150.13 + } +} \ No newline at end of file diff --git a/488/TumorCenter_CD3_block12_x6_y4_patient488_1.json b/488/TumorCenter_CD3_block12_x6_y4_patient488_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5c8973792e68a8b3190437a550b11510de308c2d --- /dev/null +++ b/488/TumorCenter_CD3_block12_x6_y4_patient488_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18290.3, + "Centroid Y µm": 9869.8, + "Num Detections": 17829, + "Num Negative": 17361, + "Num Positive": 468, + "Positive %": 2.625, + "Num Positive per mm^2": 210.05 + } +} \ No newline at end of file diff --git a/488/TumorCenter_CD8_block12_x5_y4_patient488_0.json b/488/TumorCenter_CD8_block12_x5_y4_patient488_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d015786d4f0ffc31401765b41bc82fa2c16351c --- /dev/null +++ b/488/TumorCenter_CD8_block12_x5_y4_patient488_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19407.4, + "Centroid Y µm": 19567.3, + "Num Detections": 13399, + "Num Negative": 13288, + "Num Positive": 111, + "Positive %": 0.8284, + "Num Positive per mm^2": 53.65 + } +} \ No newline at end of file diff --git a/488/TumorCenter_CD8_block12_x6_y4_patient488_1.json b/488/TumorCenter_CD8_block12_x6_y4_patient488_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4cd45c9c7e588e63c2dae9e757cf6fc7c61fa7bc --- /dev/null +++ b/488/TumorCenter_CD8_block12_x6_y4_patient488_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21776.0, + "Centroid Y µm": 19624.1, + "Num Detections": 17395, + "Num Negative": 17109, + "Num Positive": 286, + "Positive %": 1.644, + "Num Positive per mm^2": 130.26 + } +} \ No newline at end of file diff --git a/488/history_text.txt b/488/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..50eebdcee0edb872c69a88ce1a08c255bd63c1e0 --- /dev/null +++ b/488/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT3 cN2b oropharyngeal carcinoma on the right side was confirmed during a panendoscopy (<2011>). Here, circumscribed growth on the mandibular branch without evidence of mandibular infiltration in the panendoscopy or CT imaging. Now planned resection and defect coverage using a radial flap. \ No newline at end of file diff --git a/488/icd_codes.txt b/488/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/488/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/488/ops_codes.txt b/488/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..400e90457c53129a101fb4a2f5952083234f5c11 --- /dev/null +++ b/488/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Anlegen einer PEG[5-431.2 ] Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Transplantat[5-278.32 R] Transplantation Knochentransplantat gefäßgestielt mit mikrovaskulärer Anastomose sonstige[5-784.4x R] Entnahme Spongiosa eine Entnahmestelle[5-783.0 ] \ No newline at end of file diff --git a/488/patient_clinical_data.json b/488/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6f8e6ab5a1692090a63611063cb46b51100a006e --- /dev/null +++ b/488/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": null, + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/488/patient_pathological_data.json b/488/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cb9fb2c57a7249251ccad0c1d5fd290ba9fd5c1c --- /dev/null +++ b/488/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "488", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 48, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/488/surgery_description.txt b/488/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..447b6aece1567112bba650c08e3076632c76a72e --- /dev/null +++ b/488/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Defect reconstruction (Scapula flap), Tracheotomy, PEG placement diff --git a/488/surgery_report.txt b/488/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2a05d7f6a39cc7b4e673243698c023225be0719d --- /dev/null +++ b/488/surgery_report.txt @@ -0,0 +1 @@ +First, perform the PEG insertion. For this purpose, insertion with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach. Here, with good diaphanoscopy, problem-free puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. Inspection of the oesophagus on reflection. No suspicious lesions here. Now enter with the small bore tube and inspect the primary tumor with the small bore tube and the open mouth retractor. There is an exophytic growing tumor in the area of the right anterior palatal arch, passing over the glossotonsillar groove to the base of the tongue and clearly infiltrating it in depth, affecting at least 1/4 of the base of the tongue, but free vallecula and epiglottis caudally. No growth towards the hypopharynx. The tumor extends over the glossotonsillar groove onto the alveolar ridge and is located here coarsely and not displaceable. In this case, the tumor tends to grow submucosally and nodularly and is located at least 3 cm above the mandible. Urgent suspicion of mandibular infiltration here. Tumor extends anteriorly in a bumpy shape. A screening specimen was taken at the anterior margin for frozen section diagnosis. However, no tumor growth here. Now consult and discuss the case. Confirmation of the overall clear tumor progression and the high degree of suspicion of mandibular infiltration. Therefore, after detailed case discussion, decision to consult the maxillofacial surgeons. Findings demo and case discussion by telephone to . Confirmation of suspected mandibular infiltration. Primary treatment recommendation of continuous partial mandibular resection. Joint case discussion again with . Due to the thinning and lack of adequate curative treatment options for surgical restoration, the decision was made to perform primary surgical restoration with the recommended partial mandibular resection and reconstruction using a scapula flap. Neck dissection and tracheotomy performed first. Start with the neck dissection on the left side: no suspicious masses are described sonographically. Skin incision on the anterior edge of the sternocleidomastoid muscle. Cut through skin and subcutaneous tissue. Dissection of the platysma. Creation of a platysma flap. Exposure of the external jugular vein. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Clearing out the anterior neck level while carefully protecting the superior thyroid artery, the hypoglossal nerve and the cervical sinus. Now expose the internal jugular vein. Free preparation of the vein after prior exposure of the accessorius nerve. Exposure and preservation of the facial vein, the external vein was ligated and removed in the course of the oblique pulling exit. Clearing of the accessorius triangle and level V with careful protection of the cervical plexus branches and special protection of caudal lymphatic structures. Dry conditions here. Final inspection and in dry conditions, after final palpation of level Ib and inconspicuous conditions, wound irrigation with Ringer's solution and two-layer wound closure after insertion of a 10-gauge Redon drain. Now turn to the neck dissection on the opposite side: here sonographically 2 suspicious masses level II to IV. In principle the same procedure. Dissection of skin and subcutaneous tissue, dissection of the platysma, creation of a platysma flap. Exposure and preservation of the external jugular vein. Exposure of the sternocleidomastoid muscle. This can be removed from the nodular metastatic lesions measuring up to 3 cm on the internal jugular vein. No evidence of muscle infiltration here. Visualization of the omohyoid muscle. Expose the submandibular gland and the digastric muscle. Clearing of the anterior neck preparation with careful protection of the superior thyroid artery, cervical artery and hypoglossal nerve. There is no real facial vein here, but there is a very strong superior thyroid vein. Free dissection of the internal jugular vein, including the suspicious lesions. Careful dissection in the area of the vein. Clearly no infiltration of the vessel here, but vulnerable conditions. Outlets close to the vein must be ligated twice. Otherwise problem-free evacuation. Exposure of the accessorius nerve. Evacuation of the accessorius triangle and evacuation of level V with careful protection of the plexus branches. Further exposure of the external carotid artery. Exposure of the outlet of the upper laryngeal bundle and the facial vein. Now, due to the expansion, evacuation of level Ib. This is done with the submandibular gland. Careful subcapsular dissection while keeping the branch of the mouth away. Careful dissection and protection of the facial artery. A lymph node measuring a good 1 1/2 cm anterior to the gland is noticeable, otherwise no macroscopically suspicious changes in level Ib. Palpation of the floor of the mouth. No changes here. Now, with dry wound conditions, first turn to the tracheotomy. Make a horizontal incision below the cricoid cartilage. Cut through the skin and subcutaneous tissue. Expose and ligate the strong anterior jugular vein in this area. Exposure of the infrahyoid musculature. Dissection of the musculature, exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Bipolar coagulation of the thyroid isthmus and, after complete exposure of the anterior tracheal surface, insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björk flap and insertion of the tracheostoma in the usual manner. Subsequent problem-free transfer to an 8 mm tracheoflex cannula and fixation of the cannula with suture. Now use from maxillofacial surgery until osteocutaneous fixation of the graft. The mandibular branch is now sharply visualized. If the course of the mandible is tortuous, remove the facial artery as distally as possible to obtain a strong vascular stump and expose a large area of the mandibular branch ............ of the periosteum and muscle insertions. Exposure of the ascending mandibular branch up to the joint, complete freeing of the mandibular branch from the muscle processes. Now, after complete exposure, saw out approx. 6 cm of mandible after previous fixation with 2.7 from the synthesis plate, which is fixed with 12 and 14 screws. Sawing out the bone portion. This results in a circumscribed detachment of bone in the area of the mandibular angulus. This is later refixed with osteosynthesis and screws. Re-release of the plate. Therefore creation of a wide access. Entering enorally in the area of the anterior floor of the mouth. Successive resection of the tumor, taking the lateral floor of the mouth and the edge of the tongue completely up to the base of the tongue. Here, generous resection with resection of approx. 1/3 of the base of the tongue. Macroscopically and palpatorily clearly healthy. Resection towards the soft tissues of the cheek well within the healthy tissue. Resection of the tumor including the anterior palatal arch and the tonsil as far as the parauvular region, but sparing the posterior palatal arch. After caudal resection up to just before the epiglottis and also here resection of the tumor clearly in healthy tissue. Now, after extirpation of the tumor, a clear in sano resection can be seen macroscopically. Only in the area of the anterior floor of the mouth macroscopically somewhat scarce resection. Therefore, a strong resection is performed in the area of the anterior floor of the mouth. Finally, the tumor area is completely covered with continuous margin samples. These are sent for frozen section diagnostics and assessed here as completely free of tumor and dysplasia. Therefore, after meticulous hemostasis, sterile packing of the wound conditions and repositioning to elevate an osteomyocutaneous scapula flap. A separate dictation from from the MKG follows. After removal of the graft, preparation of the vascular pedicle. Successive fitting of the bony part. Difficult conditions here, but finally good fitting in the area of the bony margins. After osteosynthetic treatment, insertion of cancellous bone tissue. Final firm fit. Previous transcervical suturing of the cutaneous part in the area of the base of the tongue and the caudal pharyngeal defect as well as beginning in the area of the posterior palatal arch. Attempt to complete the cutaneous suture transorally. This is not successful due to increased tension. Therefore, renewed anterior loosening of the plating. In the meantime, renewed demonstration of findings at and . With good mobilization of the cutaneous part, problem-free transoral insertion of the graft. Finally, complete defect coverage in the area of the mucosal defect. In the area of the anterior floor of the mouth and the tongue, primary mucosal adaptation is described here, finally also palpably completely dense conditions. Repositioning of the plating. Renewed screwing. Insertion of spongiosis, circumscribed, and attention to microvascular anastomization: For this purpose, initially further exposure of the vascular pedicle. Clipping of vessels close to the stalk. After dissection, positioning of the detached facial artery with approximate caliber equivalence. Excellent flow after free dissection and placement. Free preparation of the vessel and now, after placement, perform end-to-end anastomosis with 8.0 ethinol. This is somewhat more difficult with vessels that are not exactly the same caliber, but is ultimately successful. Initially delayed venous return. After a short run-in phase, however, excellent reflux conditions with enorally regular flap perfusion. Now, after positioning of the arterial anastomosis, the best possible placement conditions for anastomization with the external jugular vein. Therefore, free preparation of the external jugular vein. Deposition after ligation. Free preparation. Measurement of a 3.5 mm coupler and problem-free execution of the coupler anastomosis. After opening the Acland clamps, immediate regular venous filling and excellent flap perfusion. Finally, circumscribed hemostasis in the area of the previously thinned muscle cuff and, in dry conditions and with good flap vitality, careful two-layer wound closure with moderate tension conditions. Due to the large area of exposed musculature in the area of the muscular graft part, the caudal part is left open cervically. Insertion of a flap and suturing and termination of the procedure at this point. Conclusion: Due to the high degree of suspicion of mandibular infiltration and the lack of equivalent curative treatment options, resection of a cT4a cN2b oropharyngeal carcinoma on the right with continuity resection of the mandible and reconstruction of the osseous defect as well as reconstruction of the enoral defect with an osseomyocutaneous scapular flap. Due to the extent of the tumor, adjuvant therapy is certainly required. The patient received intraoperative intravenous antibiotics with Unacid 3 g. Please continue this postoperatively with Unacid 1.5 g for 3 days. Postoperatively, please monitor the flap meticulously according to the known scheme. Please visit the maxillofacial clinic approx. 1 week postoperatively for an X-ray overview. From the 8th postoperative day, endoscopic check-up and, if flap vitality is normal and the conditions are dense, a clinical swallowing test and, if necessary, oral food preparation. Decannulation if necessary, depending on the diet. \ No newline at end of file diff --git a/489/InvasionFront_CD3_block4_x3_y10_patient489_0.json b/489/InvasionFront_CD3_block4_x3_y10_patient489_0.json new file mode 100644 index 0000000000000000000000000000000000000000..268dbda6f7ba7fde9f6e9d700eda441e0b1789e6 --- /dev/null +++ b/489/InvasionFront_CD3_block4_x3_y10_patient489_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 31008.6, + "Num Detections": 19795, + "Num Negative": 17840, + "Num Positive": 1955, + "Positive %": 9.876, + "Num Positive per mm^2": 805.84 + } +} \ No newline at end of file diff --git a/489/InvasionFront_CD3_block4_x4_y10_patient489_1.json b/489/InvasionFront_CD3_block4_x4_y10_patient489_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2876a3edcf96bdf41f6a37786e460b39a7d89306 --- /dev/null +++ b/489/InvasionFront_CD3_block4_x4_y10_patient489_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 31208.5, + "Num Detections": 19186, + "Num Negative": 16809, + "Num Positive": 2377, + "Positive %": 12.39, + "Num Positive per mm^2": 966.76 + } +} \ No newline at end of file diff --git a/489/InvasionFront_CD3_block4_x5_y10_patient489_2.json b/489/InvasionFront_CD3_block4_x5_y10_patient489_2.json new file mode 100644 index 0000000000000000000000000000000000000000..7053282d70565c74ba21f034704e9522f0028829 --- /dev/null +++ b/489/InvasionFront_CD3_block4_x5_y10_patient489_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 31358.4, + "Num Detections": 11624, + "Num Negative": 10469, + "Num Positive": 1155, + "Positive %": 9.936, + "Num Positive per mm^2": 712.13 + } +} \ No newline at end of file diff --git a/489/InvasionFront_CD3_block4_x6_y10_patient489_3.json b/489/InvasionFront_CD3_block4_x6_y10_patient489_3.json new file mode 100644 index 0000000000000000000000000000000000000000..4ad844b6095319fa24d2232d70be593e381a4698 --- /dev/null +++ b/489/InvasionFront_CD3_block4_x6_y10_patient489_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21088.8, + "Centroid Y µm": 31308.4, + "Num Detections": 13467, + "Num Negative": 12294, + "Num Positive": 1173, + "Positive %": 8.71, + "Num Positive per mm^2": 721.91 + } +} \ No newline at end of file diff --git a/489/InvasionFront_CD8_block4_x3_y10_patient489_0.json b/489/InvasionFront_CD8_block4_x3_y10_patient489_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6df866b7e2a4e885fbed13987922cd8944dae6c1 --- /dev/null +++ b/489/InvasionFront_CD8_block4_x3_y10_patient489_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11269.0, + "Centroid Y µm": 29959.1, + "Num Detections": 19333, + "Num Negative": 17666, + "Num Positive": 1667, + "Positive %": 8.623, + "Num Positive per mm^2": 680.9 + } +} \ No newline at end of file diff --git a/489/InvasionFront_CD8_block4_x4_y10_patient489_1.json b/489/InvasionFront_CD8_block4_x4_y10_patient489_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b3f08d268ef376dc71ccf5187fcc0d3474472df2 --- /dev/null +++ b/489/InvasionFront_CD8_block4_x4_y10_patient489_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 30059.1, + "Num Detections": 19005, + "Num Negative": 16870, + "Num Positive": 2135, + "Positive %": 11.23, + "Num Positive per mm^2": 842.92 + } +} \ No newline at end of file diff --git a/489/InvasionFront_CD8_block4_x5_y10_patient489_2.json b/489/InvasionFront_CD8_block4_x5_y10_patient489_2.json new file mode 100644 index 0000000000000000000000000000000000000000..67585e250507a36e08e63edf34b012e71a7e7fa0 --- /dev/null +++ b/489/InvasionFront_CD8_block4_x5_y10_patient489_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 29959.1, + "Num Detections": 9487, + "Num Negative": 8757, + "Num Positive": 730, + "Positive %": 7.695, + "Num Positive per mm^2": 617.46 + } +} \ No newline at end of file diff --git a/489/InvasionFront_CD8_block4_x6_y10_patient489_3.json b/489/InvasionFront_CD8_block4_x6_y10_patient489_3.json new file mode 100644 index 0000000000000000000000000000000000000000..783298339e50fa3befc2bca91c7669464da59991 --- /dev/null +++ b/489/InvasionFront_CD8_block4_x6_y10_patient489_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 29984.1, + "Num Detections": 7429, + "Num Negative": 6982, + "Num Positive": 447, + "Positive %": 6.017, + "Num Positive per mm^2": 464.76 + } +} \ No newline at end of file diff --git a/489/TumorCenter_CD3_block4_x3_y10_patient489_0.json b/489/TumorCenter_CD3_block4_x3_y10_patient489_0.json new file mode 100644 index 0000000000000000000000000000000000000000..065daf06d29e4e70a33b8045305470700a7d3d59 --- /dev/null +++ b/489/TumorCenter_CD3_block4_x3_y10_patient489_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 25711.4, + "Num Detections": 17296, + "Num Negative": 16664, + "Num Positive": 632, + "Positive %": 3.654, + "Num Positive per mm^2": 277.73 + } +} \ No newline at end of file diff --git a/489/TumorCenter_CD3_block4_x4_y10_patient489_1.json b/489/TumorCenter_CD3_block4_x4_y10_patient489_1.json new file mode 100644 index 0000000000000000000000000000000000000000..574cefd762b49926f3754730aa0d8e017f00cb8a --- /dev/null +++ b/489/TumorCenter_CD3_block4_x4_y10_patient489_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 25636.4, + "Num Detections": 17579, + "Num Negative": 14640, + "Num Positive": 2939, + "Positive %": 16.72, + "Num Positive per mm^2": 1238.0 + } +} \ No newline at end of file diff --git a/489/TumorCenter_CD3_block4_x5_y10_patient489_2.json b/489/TumorCenter_CD3_block4_x5_y10_patient489_2.json new file mode 100644 index 0000000000000000000000000000000000000000..8295589d9f3d5e46cade79d51d33b7417960d16b --- /dev/null +++ b/489/TumorCenter_CD3_block4_x5_y10_patient489_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 25661.4, + "Num Detections": 11586, + "Num Negative": 10614, + "Num Positive": 972, + "Positive %": 8.389, + "Num Positive per mm^2": 657.84 + } +} \ No newline at end of file diff --git a/489/TumorCenter_CD3_block4_x6_y10_patient489_3.json b/489/TumorCenter_CD3_block4_x6_y10_patient489_3.json new file mode 100644 index 0000000000000000000000000000000000000000..15f10857a972a19449d7d0f1afa5ddd2e2d5f4dd --- /dev/null +++ b/489/TumorCenter_CD3_block4_x6_y10_patient489_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 25636.4, + "Num Detections": 8858, + "Num Negative": 6564, + "Num Positive": 2294, + "Positive %": 25.9, + "Num Positive per mm^2": 2122.4 + } +} \ No newline at end of file diff --git a/489/TumorCenter_CD8_block4_x3_y10_patient489_0.json b/489/TumorCenter_CD8_block4_x3_y10_patient489_0.json new file mode 100644 index 0000000000000000000000000000000000000000..27ffc038196829020ce0cd00dd52b6f1c5f11de2 --- /dev/null +++ b/489/TumorCenter_CD8_block4_x3_y10_patient489_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 25636.4, + "Num Detections": 16711, + "Num Negative": 16211, + "Num Positive": 500, + "Positive %": 2.992, + "Num Positive per mm^2": 216.13 + } +} \ No newline at end of file diff --git a/489/TumorCenter_CD8_block4_x4_y10_patient489_1.json b/489/TumorCenter_CD8_block4_x4_y10_patient489_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3af0745cd6e18379130101a918d533c1c5179471 --- /dev/null +++ b/489/TumorCenter_CD8_block4_x4_y10_patient489_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 25711.4, + "Num Detections": 18473, + "Num Negative": 15487, + "Num Positive": 2986, + "Positive %": 16.16, + "Num Positive per mm^2": 1205.7 + } +} \ No newline at end of file diff --git a/489/TumorCenter_CD8_block4_x5_y10_patient489_2.json b/489/TumorCenter_CD8_block4_x5_y10_patient489_2.json new file mode 100644 index 0000000000000000000000000000000000000000..b2316858b954e3dd36f791e1ec82f845bf3ea1b9 --- /dev/null +++ b/489/TumorCenter_CD8_block4_x5_y10_patient489_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 25911.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/489/TumorCenter_CD8_block4_x6_y10_patient489_3.json b/489/TumorCenter_CD8_block4_x6_y10_patient489_3.json new file mode 100644 index 0000000000000000000000000000000000000000..d12ae758e8b9e3758a21649cae7cb90259d9399d --- /dev/null +++ b/489/TumorCenter_CD8_block4_x6_y10_patient489_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 26386.0, + "Num Detections": 7947, + "Num Negative": 7179, + "Num Positive": 768, + "Positive %": 9.664, + "Num Positive per mm^2": 799.51 + } +} \ No newline at end of file diff --git a/489/history_text.txt b/489/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8e6835db85b9ab145a1ce386d7d13e309060a3c8 --- /dev/null +++ b/489/history_text.txt @@ -0,0 +1 @@ +The patient has a cT2 soft palate carcinoma on the right. The patient has reported pain in the palate area for approximately one year. The previous panendoscopy and sampling <2016> showed a keratinizing squamous cell carcinoma that crossed the midline with a cN0 neck status. Thus indication for the above procedure. \ No newline at end of file diff --git a/489/icd_codes.txt b/489/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..950718dd10812517e99aa0aca4e81533b531139a --- /dev/null +++ b/489/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Mund mehrere Teilbereiche überlappend[C06.8 B] Karzinom Mund mehrere Teilbereiche überlappend[C06.8 B] \ No newline at end of file diff --git a/489/ops_codes.txt b/489/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a30433792dac653acd8c41783aa45a6113216c5 --- /dev/null +++ b/489/ops_codes.txt @@ -0,0 +1 @@ +Gaumentumorexzision[5-272.0 ] Gaumentumorexzision[5-272.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Anlegen einer PEG durch Fadendurchzugsmethode[5-431.20 ] Anlegen einer PEG durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/489/patient_clinical_data.json b/489/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3dff1f621ecd3ad7b6c66e164cc982d3180febd6 --- /dev/null +++ b/489/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 6, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/489/patient_pathological_data.json b/489/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..616c39907e53ab68f975a442cc364b2143a7b395 --- /dev/null +++ b/489/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "489", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/489/surgery_description.txt b/489/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fd93aadeac650f0d2145da68cd29b88366a9bd63 --- /dev/null +++ b/489/surgery_description.txt @@ -0,0 +1 @@ +Tumor excision, Neck dissection, PEG placement diff --git a/489/surgery_report.txt b/489/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2af80173ebafd8d69a56513a28c9a4f2d47b813b --- /dev/null +++ b/489/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Identification of the patient. Insertion of the Jennings retractor and re-inspection of the tumorous mass. This can be seen on the right side at the transition from the soft palate to the hard palate, but crossing the midline. The tumorous mass is then carefully excised using bipolar coagulation. Here, sufficient attention is paid to a safe distance so that a large part of the mucosa and submucosal tissue is removed from the hard palate, the bone is exposed at this point, taking the soft palate with it. After careful hemostasis, marginal samples are taken. These are submitted for frozen section diagnostics. The patient is then repositioned for neck dissection on both sides. Start on the right side. Repeated cervical skin spray disinfection on both sides and infiltration anesthesia. Skin wipe disinfection and sterile draping. Skin incision on the right side cranially behind the mastoid, anteriorly over the sternocleidomastoid muscle, which ends at the anterior edge of the sternocleidomastoid muscle. The sternocleidomastoid muscle is shown here. Exposure of the cervical vascular sheath and dissection of the internal jugular vein, the common carotid artery, the bifurcation as well as the external and internal carotid artery. Exposure and sparing of the vagus nerve and the accessorius nerve. Displacement and, at the end of the operation, re-embedding of the vagus nerve and accessorius nerve in the sense of a neurolysis. Exposure of the posterior digastric venter muscle. Exposure of the hypoglossal nerve and protection of the same. Displacement and, at the end of the operation, re-embedding of the nerve in the sense of a neurolysis. Development of the lateral neck preparation while sparing all the structures mentioned. The same applies to the median neck preparation. Exposure of the submandibular gland. Strict care is taken not to interrupt the venous ..............................der ............................. flow. Complete evacuation of levels II to V. Careful hemostasis and insertion of a Redon drainage. Subcutaneous suture and skin suture. Application of a pressure bandage. Moving to the opposite side. Also mark the planned incision here. Sharp cutting of the cutis and subcutis. Expose the sternocleidomastoid muscle. Exposure and protection of the auricularis magnus nerve. Displacement and, at the end of the operation, re-embedding of the auricularis magnus nerve in the sense of a neurolysis. Turning to the cervical vascular sheath. Exposure of the internal jugular vein and the common carotid artery, the bifurcation and the internal and external carotid artery. Exposure of the posterior digastric venter muscle. Exposure and dissection of the submandibular gland. Exposure of the hypoglossal nerve and protection of the same. Displacement and, at the end of the operation, re-embedding of the nerve in the sense of a neurolysis. Here, too, the region II to V is completely evacuated at the end. At the end of the operation, careful hemostasis and insertion of a 10 Redon drain. Subcutaneous suture and skin suture. Application of a pressure bandage. The marginal samples were found to be tumor-free during frozen section diagnostics, so that the reattachment of the oral retractor was carried out at the end of the procedure. Another careful wound inspection. If the wound is dry, the procedure is completed. Final consultation with the anesthetist. Conclusion: Overall complication-free excision of a cT2 tumorous mass of the soft and hard palate on the right side with midline crossing and problem-free neck dissection on both sides. The further procedure should be planned after receipt of the final histology. \ No newline at end of file diff --git a/490/InvasionFront_CD3_block4_x5_y4_patient490_0.json b/490/InvasionFront_CD3_block4_x5_y4_patient490_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1340bdbf65b5e7f26989a0621eac796cdb573d30 --- /dev/null +++ b/490/InvasionFront_CD3_block4_x5_y4_patient490_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 16391.3, + "Num Detections": 15909, + "Num Negative": 15555, + "Num Positive": 354, + "Positive %": 2.225, + "Num Positive per mm^2": 163.94 + } +} \ No newline at end of file diff --git a/490/InvasionFront_CD3_block4_x6_y4_patient490_1.json b/490/InvasionFront_CD3_block4_x6_y4_patient490_1.json new file mode 100644 index 0000000000000000000000000000000000000000..28a25fecffcfa9db1ba6de774b2ce2fcec4485b8 --- /dev/null +++ b/490/InvasionFront_CD3_block4_x6_y4_patient490_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21688.5, + "Centroid Y µm": 16491.3, + "Num Detections": 17044, + "Num Negative": 16643, + "Num Positive": 401, + "Positive %": 2.353, + "Num Positive per mm^2": 170.41 + } +} \ No newline at end of file diff --git a/490/InvasionFront_CD8_block4_x5_y4_patient490_0.json b/490/InvasionFront_CD8_block4_x5_y4_patient490_0.json new file mode 100644 index 0000000000000000000000000000000000000000..96f8779f8a0655388698c0bea098430ba21e2b44 --- /dev/null +++ b/490/InvasionFront_CD8_block4_x5_y4_patient490_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16403.8, + "Centroid Y µm": 14942.1, + "Num Detections": 13928, + "Num Negative": 13661, + "Num Positive": 267, + "Positive %": 1.917, + "Num Positive per mm^2": 130.65 + } +} \ No newline at end of file diff --git a/490/InvasionFront_CD8_block4_x6_y4_patient490_1.json b/490/InvasionFront_CD8_block4_x6_y4_patient490_1.json new file mode 100644 index 0000000000000000000000000000000000000000..409ac66d257ac60963e97a77b8eaf2f22f2b41a1 --- /dev/null +++ b/490/InvasionFront_CD8_block4_x6_y4_patient490_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 15004.6, + "Num Detections": 15401, + "Num Negative": 15129, + "Num Positive": 272, + "Positive %": 1.766, + "Num Positive per mm^2": 113.37 + } +} \ No newline at end of file diff --git a/490/TumorCenter_CD3_block4_x5_y4_patient490_0.json b/490/TumorCenter_CD3_block4_x5_y4_patient490_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c436c75fc9e6a98f3b9ea7a59fce7e26fe9c5220 --- /dev/null +++ b/490/TumorCenter_CD3_block4_x5_y4_patient490_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 10344.5, + "Num Detections": 14504, + "Num Negative": 14341, + "Num Positive": 163, + "Positive %": 1.124, + "Num Positive per mm^2": 72.7 + } +} \ No newline at end of file diff --git a/490/TumorCenter_CD3_block4_x6_y4_patient490_1.json b/490/TumorCenter_CD3_block4_x6_y4_patient490_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f4d3859bf636c76c0c0ecbe0ff006af43df9626f --- /dev/null +++ b/490/TumorCenter_CD3_block4_x6_y4_patient490_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 10369.5, + "Num Detections": 15599, + "Num Negative": 15473, + "Num Positive": 126, + "Positive %": 0.8077, + "Num Positive per mm^2": 56.92 + } +} \ No newline at end of file diff --git a/490/TumorCenter_CD8_block4_x5_y4_patient490_0.json b/490/TumorCenter_CD8_block4_x5_y4_patient490_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5f8ace8af949c98e26037fee2f317ad508ffc1e0 --- /dev/null +++ b/490/TumorCenter_CD8_block4_x5_y4_patient490_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 10369.5, + "Num Detections": 17463, + "Num Negative": 17342, + "Num Positive": 121, + "Positive %": 0.6929, + "Num Positive per mm^2": 53.66 + } +} \ No newline at end of file diff --git a/490/TumorCenter_CD8_block4_x6_y4_patient490_1.json b/490/TumorCenter_CD8_block4_x6_y4_patient490_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65a81891efc3cbb6c6b331e4c927e088d145212c --- /dev/null +++ b/490/TumorCenter_CD8_block4_x6_y4_patient490_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19539.7, + "Centroid Y µm": 10569.4, + "Num Detections": 14855, + "Num Negative": 14827, + "Num Positive": 28, + "Positive %": 0.1885, + "Num Positive per mm^2": 12.42 + } +} \ No newline at end of file diff --git a/490/history_text.txt b/490/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/490/icd_codes.txt b/490/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/490/ops_codes.txt b/490/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dc087e9634d7bb273857bad69e5b213abf28131d --- /dev/null +++ b/490/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/490/patient_clinical_data.json b/490/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1a4df3eaa3c3fd9f8042c3efb9efea5157113e4f --- /dev/null +++ b/490/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 77, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/490/patient_pathological_data.json b/490/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..46e664d18f887ab6c0825f57e905f1dd71f56a4c --- /dev/null +++ b/490/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "490", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 34, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Acantholytic", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/490/surgery_description.txt b/490/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..006b02a0de733efdd506e1816934a263841ce6b2 --- /dev/null +++ b/490/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, Tracheotomy diff --git a/490/surgery_report.txt b/490/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..50d5b6b5f3e96797753e82b1e0ba155eed8ac4d0 --- /dev/null +++ b/490/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesiologist. Performing a microlaryngoscopy, where a broad-based tumor is found relatively centrally in the area of the base of the tongue, which here bulges strongly exophytically into the pharynx. The lateral wall of the pharynx is merely adjacent to the tumor, as is the posterior wall of the pharynx, where there is certainly no infiltration by the tumor. Removal of the MLE tube. Perform gastroscopy and PEG insertion. The flexible instrument can be inserted into the esophagus without any problems, and the tube can be advanced under visualization into the stomach, where a regular folded relief can be seen. After distension of the stomach, a positive diaphanoscopy reveals a good puncture site below the costal arch. Here the PEG tube is placed using the thread pull-through method and with a positive tent phenomenon. This is successful without any problems. Fixation of the PEG tube with the holding plate and dressing. Reflect back and inspect the esophageal mucosa, which is unremarkable. Repositioning of the patient and insertion of the size B small bore tube and exploration of the base of the tongue. This is only insufficiently successful, so the small water tube is changed to the TORS barrier. This allows sufficient exposure of the tumor so that laser resection can now be performed successively. The resection is carried out far into the base of the tongue, as there is considerable infiltration of the tumor here. Due to the complexity, a large part of the exophytic part of the tumor must be resected first. It is now possible to expose the base of the tumor better and to laser the tumor out of the base of the tongue. The tumor is located so centrally that the lingual artery is not endangered on either side, even with deep resection. Representative frozen sections are taken, whereby a marginal sample in the area of the base of the tongue proves to be positive. This area is resected again generously and finally another marginal sample is taken, which is found to be tumor-free by the pathologists in the frozen section during the further course of the resection. Subtle hemostasis. The resection is performed via the vallecula up to the lingual epiglottis surface. The base of the epiglottis is also infiltrated by the tumor. However, the cartilage is certainly affected so that the tumor can ultimately be completely resected while preserving the epiglottis. Representative marginal samples for frozen section diagnostics are also taken from the area of the vallecula and the epiglottis, all of which are found to be tumor-free intraoperatively. Repeated subtle hemostasis. Repositioning of the patient for neck dissection on both sides and tracheotomy. Application of local anesthesia on both sides of the neck. Skin ablation of the entire neck and sterile draping. Start on the right side. Creation of a skin incision along the anterior edge of the sternocleidomastoid muscle. Cut through the subcutaneous tissue and platysma. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle caudally and the digaster muscle (posterior cranial venter). Exposure of the cranial accessorius nerve. Displacement and at the end of the operation re-embedding of the accessorius nerve in the sense of a neurolysis. Exposure of the cranial hypoglossal nerve. Displacement and at the end of the operation re-embedding of the hypoglossal nerve in the sense of a neurolysis. Exposure of the cervical vascular sheath from caudal to cranial up to the digaster. Successive removal of the posterior and then anterior neck specimen containing the lymph nodes. Protection of the above-mentioned structures. Hemostasis using bipolar coagulation. Irrigation of the wound using hydrogen peroxide and Ringer's solution. Dry conditions. Insertion of a 10-gauge Redon drain. Two-layer wound closure. Application of a pressure dressing. Repositioning of the patient for neck dissection on the left. Creation of a skin incision along the anterior edge of the sternocleidomastoid muscle. Dissection of the subcutaneous tissue and the platysma. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure and ligation of the external jugular vein. Exposure of the omohyoid muscle. Dissection along the omohyoid muscle cranially to the hyoid bone and the capsule of the submandibular gland. Cranial exposure of the posterior venter of the digaster muscle. Exposure of the accessorius nerve. Displacement and, at the end of the operation, re-embedding of the accessory nerve in the sense of a neurolysis. Exposure of the cervical vascular sheath. Dissection along the internal jugular vein, the vagus nerve and the common carotid artery from caudal to cranial up to the digaster. Displacement and at the end of the operation re-embedding of the vagus nerve in the sense of a neurolysis. A highly suspicious lymph node is found in the area of the upper venous angle, which is also removed with the neck preparation. Another suspicious lymph node is found in region IV on the left side. Successive removal of the posterior neck specimen while sparing the above-mentioned structures and the plexus branches. Removal of the anterior neck specimen. Repeated inspection. Irrigation of the wound with hydrogen peroxide and Ringer's solution. Dry conditions. Insertion of a 10-gauge Redon drain. Platysma suture. Single button skin suture. Application of a pressure bandage. Subsequent creation of an approx. 3.5 cm long incision below the cricoid cartilage. Separation of the subcutaneous tissue. Exposure of both branches of the anterior jugular vein, which are ligated separately. Exposure of the prelaryngeal musculature. Lateral displacement of the prelaryngeal musculature on the right and left. Exposure of the thyroid isthmus, which is undermined, clamped and severed. Subsequently, both sides are treated by means of re-stitching. Exposure of the anterior wall of the trachea. Creation of a Björ flap in a typical manner after incision between the 2nd and 3rd tracheal cartilage clasp. Creation of a plastic tracheostoma. Skin suture. Re-intubation of the patient to a size 8 tracheostomy tube. Regular conditions. Application of a pressure bandage. Completion of the procedure without complications. Final consultation with the anesthetist. \ No newline at end of file diff --git a/491/InvasionFront_CD8_block5_x5_y12_patient491_0.json b/491/InvasionFront_CD8_block5_x5_y12_patient491_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e0dd1eaec67ae0fa2786f20a5f42f638e2a8488f --- /dev/null +++ b/491/InvasionFront_CD8_block5_x5_y12_patient491_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 29909.2, + "Num Detections": 27703, + "Num Negative": 27489, + "Num Positive": 214, + "Positive %": 0.7725, + "Num Positive per mm^2": 83.95 + } +} \ No newline at end of file diff --git a/491/InvasionFront_CD8_block5_x6_y12_patient491_1.json b/491/InvasionFront_CD8_block5_x6_y12_patient491_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b0eb416c1c02ce8fc7c8353711b98fdaed9b043b --- /dev/null +++ b/491/InvasionFront_CD8_block5_x6_y12_patient491_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 29834.2, + "Num Detections": 22286, + "Num Negative": 21644, + "Num Positive": 642, + "Positive %": 2.881, + "Num Positive per mm^2": 273.48 + } +} \ No newline at end of file diff --git a/491/TumorCenter_CD3_block5_x5_y12_patient491_0.json b/491/TumorCenter_CD3_block5_x5_y12_patient491_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8866321ddf872edc05f28da687e333083f1a2847 --- /dev/null +++ b/491/TumorCenter_CD3_block5_x5_y12_patient491_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15273.0, + "Centroid Y µm": 30249.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/491/TumorCenter_CD3_block5_x6_y12_patient491_1.json b/491/TumorCenter_CD3_block5_x6_y12_patient491_1.json new file mode 100644 index 0000000000000000000000000000000000000000..073dd2e44b2344d9ea78aded679e97efc8960714 --- /dev/null +++ b/491/TumorCenter_CD3_block5_x6_y12_patient491_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17715.6, + "Centroid Y µm": 30408.9, + "Num Detections": 22629, + "Num Negative": 21599, + "Num Positive": 1030, + "Positive %": 4.552, + "Num Positive per mm^2": 455.19 + } +} \ No newline at end of file diff --git a/491/TumorCenter_CD8_block5_x5_y12_patient491_0.json b/491/TumorCenter_CD8_block5_x5_y12_patient491_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14f33881b61d12adfab561185e86d361ebd9d678 --- /dev/null +++ b/491/TumorCenter_CD8_block5_x5_y12_patient491_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 30333.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/491/TumorCenter_CD8_block5_x6_y12_patient491_1.json b/491/TumorCenter_CD8_block5_x6_y12_patient491_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc7b9583c22e43dbf455d686aa24985cb0ad0837 --- /dev/null +++ b/491/TumorCenter_CD8_block5_x6_y12_patient491_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 30159.0, + "Num Detections": 24338, + "Num Negative": 24019, + "Num Positive": 319, + "Positive %": 1.311, + "Num Positive per mm^2": 136.93 + } +} \ No newline at end of file diff --git a/491/history_text.txt b/491/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f2cdeaa23cfaea78f7e66d20f4485cbd2a105d1f --- /dev/null +++ b/491/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma after lymph node removal. PET-CT showed a left tonsil focus. Surgery therefore indicated. \ No newline at end of file diff --git a/491/icd_codes.txt b/491/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc92ceb4a5d2e8b12a16195e15071dbb7c42cfd2 --- /dev/null +++ b/491/icd_codes.txt @@ -0,0 +1 @@ +Rachenmandelkarzinom[C11.1 L] \ No newline at end of file diff --git a/491/ops_codes.txt b/491/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4cdda02895f636016210af0eb35fe9dffabcaa00 --- /dev/null +++ b/491/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] \ No newline at end of file diff --git a/491/patient_clinical_data.json b/491/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cf4c591be348eb0438dbd27f5c5f63d954a6af7a --- /dev/null +++ b/491/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/491/patient_pathological_data.json b/491/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..99b6be791faf48cb63f0905e218ee8a322c639b5 --- /dev/null +++ b/491/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "491", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/491/surgery_description.txt b/491/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..08de7dca4ceaf2e8c713bf845764286c5ce3bb70 --- /dev/null +++ b/491/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy, Left-sided neck dissection diff --git a/491/surgery_report.txt b/491/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..08576c5cf68d44e2c9bc1495e56ccd4bb8399c38 --- /dev/null +++ b/491/surgery_report.txt @@ -0,0 +1 @@ +First of all, another pharyngoscopy and laryngoscopy: There is no further clinical evidence of a mass, apart from the hardening in the area of the left tonsil. However, a tonsil stone had been retrieved here during the pre-panendoscopy. However, an indurated tonsil was found, the induration also extends into the soft tissue slightly outside the left tonsil. Therefore, clear cutting outside the tonsil border cranially and also laterally as well as to the depth, entraining mucosa and also muscle tissue. Successive removal of the tonsil and attached soft tissue macroscopically clearly in healthy tissue, in the sense of an extended tonsillectomy. Resection caudally to the base of the tongue. The muscles, including the pterygoid muscles, are removed towards the depths. The posterior palatal arch can initially be completely preserved, while the anterior arch is completely resected. Muscle parts in the palatal arch area are also preserved. The specimen is marked with sutures. Separate cranial medial and cranial lateral margin specimens as soft tissue margin specimens. In the frozen section with infiltrations, which form margins in the cranial and medial areas. The two soft tissue margin samples towards the depth are healthy. Therefore, recutting of mucosal strips with attached soft tissue cranially in the entire area and medially. Tumor is marked with suture in each case remote from the tumor. No more infiltrates in the frozen section, so now R0 resection. In view of the situation, neck dissection is now also possible and indicated. Injection of a total of 10 ml Ultracaine 1% with adrenaline. Sterile draping. Skin incision including the old scar. Laborious dissection through the scar tissue. Exposure of the sternocleidomastoid muscle. Exposure of the digastric and omohyoid muscles. Exposure and preservation of the external jugular vein. Exposure and preservation of the facial vein. Exposure and preservation of the internal jugular vein and external carotid artery. Visualization and preservation of the vagus nerve. Extreme scarring anterior to the vein or artery around the facial vein and around the capsule of the submandibular gland. This is dissected free. Level II to V are then evacuated while preserving the branches of the cervical plexus. Finally, careful hemostasis. Irrigation. Wound closure with 3-0 Vicryl single button sutures and 4-0 skin sutures and insertion of a Redon drain. Subsequent enoral inspection. No bleeding. The procedure was completed without complications. Overall cT1 to 2, more likely cT2 tonsillar carcinoma on the left, R0 according to marginal samples. Neck dissection at least cN1. Please attend the interdisciplinary tumor conference after receiving the final histology. If, contrary to expectations, there is no R0 resection at one site, flap coverage must be discussed. \ No newline at end of file diff --git a/492/InvasionFront_CD3_block10_x1_y10_patient492_0.json b/492/InvasionFront_CD3_block10_x1_y10_patient492_0.json new file mode 100644 index 0000000000000000000000000000000000000000..29af58871aa77e3cfa69c15d42efe83618ed9696 --- /dev/null +++ b/492/InvasionFront_CD3_block10_x1_y10_patient492_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4621.0, + "Centroid Y µm": 30195.3, + "Num Detections": 15454, + "Num Negative": 15370, + "Num Positive": 84, + "Positive %": 0.5435, + "Num Positive per mm^2": 34.99 + } +} \ No newline at end of file diff --git a/492/InvasionFront_CD3_block10_x2_y10_patient492_1.json b/492/InvasionFront_CD3_block10_x2_y10_patient492_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d7d336fc87571d94b90ddec3c6c9c29ca3c7d930 --- /dev/null +++ b/492/InvasionFront_CD3_block10_x2_y10_patient492_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7075.9, + "Centroid Y µm": 30459.3, + "Num Detections": 16166, + "Num Negative": 16028, + "Num Positive": 138, + "Positive %": 0.8536, + "Num Positive per mm^2": 57.97 + } +} \ No newline at end of file diff --git a/492/InvasionFront_CD8_block10_x1_y10_patient492_0.json b/492/InvasionFront_CD8_block10_x1_y10_patient492_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1aaef9c4d81ae3c150577bd4bf680c68b7cf32d2 --- /dev/null +++ b/492/InvasionFront_CD8_block10_x1_y10_patient492_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5022.3, + "Centroid Y µm": 31508.3, + "Num Detections": 19383, + "Num Negative": 19352, + "Num Positive": 31, + "Positive %": 0.1599, + "Num Positive per mm^2": 13.11 + } +} \ No newline at end of file diff --git a/492/InvasionFront_CD8_block10_x2_y10_patient492_1.json b/492/InvasionFront_CD8_block10_x2_y10_patient492_1.json new file mode 100644 index 0000000000000000000000000000000000000000..630ffaf84b167d1864d49deb867348c46db1b1f2 --- /dev/null +++ b/492/InvasionFront_CD8_block10_x2_y10_patient492_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7496.0, + "Centroid Y µm": 31508.3, + "Num Detections": 19155, + "Num Negative": 19088, + "Num Positive": 67, + "Positive %": 0.3498, + "Num Positive per mm^2": 27.58 + } +} \ No newline at end of file diff --git a/492/TumorCenter_CD3_block10_x1_y10_patient492_0.json b/492/TumorCenter_CD3_block10_x1_y10_patient492_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f234eb55864f464e1a6062ded99e115ead8c1c6e --- /dev/null +++ b/492/TumorCenter_CD3_block10_x1_y10_patient492_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6946.3, + "Centroid Y µm": 24911.8, + "Num Detections": 4877, + "Num Negative": 4805, + "Num Positive": 72, + "Positive %": 1.476, + "Num Positive per mm^2": 115.3 + } +} \ No newline at end of file diff --git a/492/TumorCenter_CD3_block10_x2_y10_patient492_1.json b/492/TumorCenter_CD3_block10_x2_y10_patient492_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d04f181b0d27aaf02b09c3ae56a4ac2a32c58a3 --- /dev/null +++ b/492/TumorCenter_CD3_block10_x2_y10_patient492_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9270.1, + "Centroid Y µm": 24811.9, + "Num Detections": 20564, + "Num Negative": 20340, + "Num Positive": 224, + "Positive %": 1.089, + "Num Positive per mm^2": 90.21 + } +} \ No newline at end of file diff --git a/492/TumorCenter_CD8_block10_x1_y10_patient492_0.json b/492/TumorCenter_CD8_block10_x1_y10_patient492_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ddd43810a3889c8f9e1e54c4602b4b31fcb5360b --- /dev/null +++ b/492/TumorCenter_CD8_block10_x1_y10_patient492_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4372.7, + "Centroid Y µm": 26011.2, + "Num Detections": 17875, + "Num Negative": 17798, + "Num Positive": 77, + "Positive %": 0.4308, + "Num Positive per mm^2": 32.03 + } +} \ No newline at end of file diff --git a/492/TumorCenter_CD8_block10_x2_y10_patient492_1.json b/492/TumorCenter_CD8_block10_x2_y10_patient492_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a2e697305f0378c10ee0e7410172981c4e6e99db --- /dev/null +++ b/492/TumorCenter_CD8_block10_x2_y10_patient492_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 25886.3, + "Num Detections": 20418, + "Num Negative": 20286, + "Num Positive": 132, + "Positive %": 0.6465, + "Num Positive per mm^2": 52.01 + } +} \ No newline at end of file diff --git a/492/history_text.txt b/492/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/492/icd_codes.txt b/492/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/492/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/492/ops_codes.txt b/492/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..523ad206728ea7d335c71e02d893c9b8151c3201 --- /dev/null +++ b/492/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Rekonstruktion mit lokaler Schleimhaut[5-295.01 ] Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische indirekte Pharyngoskopie[1-611.1 ] Diagnostische Rhinoskopie[1-612 ] \ No newline at end of file diff --git a/492/patient_clinical_data.json b/492/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..27217d36964d15b5b51570c21429bb2a105452dc --- /dev/null +++ b/492/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/492/patient_pathological_data.json b/492/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5ee87ffc28f4f6a046a684fe73407657e4e80152 --- /dev/null +++ b/492/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "492", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Sarcomatoid", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/492/surgery_description.txt b/492/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0d1963b6a361d02956086ab15ece9482de876d7 --- /dev/null +++ b/492/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy and transoral tumor resection diff --git a/492/surgery_report.txt b/492/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..05cdc8b71026df56002e8edd8b118c6b2f92e0cc --- /dev/null +++ b/492/surgery_report.txt @@ -0,0 +1 @@ +After intubation anesthesia of the patient by the anesthesia colleagues, first rigid tracheobronchoscopy as part of the laryngoscopic intubation. If the conditions are normal, the patient can be intubated without any problems. Subsequent endoscopy of the patient's oral cavity, pharynx, hypopharynx and larynx, revealing a highly exophytic mass originating from the left tonsil. Cranial to this mass there are smaller exophytic islands in the mucosal level of the soft palate. These do not reach the uvula. Otherwise, the mucosa is completely normal and inconspicuous in the entire mirror area. A representative sample is then taken for frozen section diagnostics. The findings are diagnosed as a squamous cell carcinoma. Then insertion of the Olympus retractor and exposure of the tonsil together with the tumor on the left side. Then insertion of the robotic arms and start of the TORS resection. The dissection is also performed using a monopolar spatula. Start of resection on the soft palate. Resection is performed up to the parauvular level. First resection laterally in the region of the anterior palatal arch and then dorsally in the region of the posterior palatal arch. Dissection is performed with subtle hemostasis up to the lower tonsil pole. The tumor is then deposited here with a sufficient safety margin below the lower tonsil pole. The specimen is then thread-marked as a whole for histopathological tissue examination. In the frozen section, the finding of an rCIS finding with micro-islands of invasive carcinoma in the area of the margin of the posterior palatal arch, in particular in the caudal region of the margin extending beyond the middle to the cranial side, is found. Subsequent resection of a strip from the posterior palatal arch to the caudal settling area. A strip of mucosa is then removed as a new representative marginal sample, with the suture markings placed cranially in each case. This new marginal sample is then also found to be tumor-free intraoperatively as a frozen section, so that an R0 resection can now be assumed here. Now that there is a somewhat larger defect in the posterior palatal arch, a uvuloplasty is performed to reconstruct the posterior soft palate. This is then followed by subtle hemostasis and removal of the robotic instruments. After checking the bleeding again, the oral retractor is also removed. The patient is then repositioned for neck dissection on the left side. Here, the skin incision is first made along the sternocleidomastoid muscle. Then dissect in depth in layers and expose the neck vessel sheath. Free preparation of the cervical vascular sheath and preparation of the lateral neck preparation as well as preparation of all resection borders in the sense of the omohyoid muscle, the capsule of the submandibular gland and the digaster muscle. A suspicious lymph node change can then be seen in the accessorius triangle. This area is then initially removed here in the sense of a level IIa evacuation while sparing the accessorius nerve. Then further development of the entire lateral neck preparation in the sense of level III and IV. Then clearing of the hypoglossal triangle while sparing the hypoglossal nerve and the branches of the external carotid artery and internal jugular artery in the sense of clearing Level Ib and the posterior margin Level Ia. Then complete dissection of the anterior neck preparation in the sense of level V, also with careful dissection of the branches of the external carotid artery and internal jugular artery. Subsequent subtle hemostasis and irrigation of the wound. Insertion of a Redon drain and subsequent two-layer wound closure and dressing. The patient is then extubated without any problems after the procedure has been completed. Further procedure depending on the final histopathological findings. \ No newline at end of file diff --git a/493/InvasionFront_CD3_block16_x5_y8_patient493_0.json b/493/InvasionFront_CD3_block16_x5_y8_patient493_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3300c3173352ae219cced9122ef4ca17178fd184 --- /dev/null +++ b/493/InvasionFront_CD3_block16_x5_y8_patient493_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16698.5, + "Centroid Y µm": 24521.0, + "Num Detections": 16167, + "Num Negative": 14992, + "Num Positive": 1175, + "Positive %": 7.268, + "Num Positive per mm^2": 535.06 + } +} \ No newline at end of file diff --git a/493/InvasionFront_CD3_block16_x6_y8_patient493_1.json b/493/InvasionFront_CD3_block16_x6_y8_patient493_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9ae882598d7f1b48de46b13a0f98a44b58db38bf --- /dev/null +++ b/493/InvasionFront_CD3_block16_x6_y8_patient493_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19169.3, + "Centroid Y µm": 24569.4, + "Num Detections": 18564, + "Num Negative": 15827, + "Num Positive": 2737, + "Positive %": 14.74, + "Num Positive per mm^2": 1215.7 + } +} \ No newline at end of file diff --git a/493/InvasionFront_CD8_block16_x5_y8_patient493_0.json b/493/InvasionFront_CD8_block16_x5_y8_patient493_0.json new file mode 100644 index 0000000000000000000000000000000000000000..66a538f4ae5ab4f226a78f4ad862d25ba56659f5 --- /dev/null +++ b/493/InvasionFront_CD8_block16_x5_y8_patient493_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 19939.4, + "Num Detections": 14523, + "Num Negative": 13832, + "Num Positive": 691, + "Positive %": 4.758, + "Num Positive per mm^2": 402.25 + } +} \ No newline at end of file diff --git a/493/InvasionFront_CD8_block16_x6_y8_patient493_1.json b/493/InvasionFront_CD8_block16_x6_y8_patient493_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d0318793c670a5edfcaed23d6d14b6bb83a400dc --- /dev/null +++ b/493/InvasionFront_CD8_block16_x6_y8_patient493_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 19939.4, + "Num Detections": 18433, + "Num Negative": 16116, + "Num Positive": 2317, + "Positive %": 12.57, + "Num Positive per mm^2": 1069.9 + } +} \ No newline at end of file diff --git a/493/TumorCenter_CD3_block16_x5_y8_patient493_0.json b/493/TumorCenter_CD3_block16_x5_y8_patient493_0.json new file mode 100644 index 0000000000000000000000000000000000000000..89ab8d0334c54f274d88d24540527d4271a53f96 --- /dev/null +++ b/493/TumorCenter_CD3_block16_x5_y8_patient493_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16641.2, + "Centroid Y µm": 20839.0, + "Num Detections": 19186, + "Num Negative": 14631, + "Num Positive": 4555, + "Positive %": 23.74, + "Num Positive per mm^2": 2052.1 + } +} \ No newline at end of file diff --git a/493/TumorCenter_CD3_block16_x6_y8_patient493_1.json b/493/TumorCenter_CD3_block16_x6_y8_patient493_1.json new file mode 100644 index 0000000000000000000000000000000000000000..76e5187a86b94bc8ab6678948a84b3db61649037 --- /dev/null +++ b/493/TumorCenter_CD3_block16_x6_y8_patient493_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19114.9, + "Centroid Y µm": 21013.9, + "Num Detections": 17991, + "Num Negative": 13182, + "Num Positive": 4809, + "Positive %": 26.73, + "Num Positive per mm^2": 2089.5 + } +} \ No newline at end of file diff --git a/493/TumorCenter_CD8_block16_x5_y8_patient493_0.json b/493/TumorCenter_CD8_block16_x5_y8_patient493_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5981977502c742f6f9f697b07f9869b537d1f438 --- /dev/null +++ b/493/TumorCenter_CD8_block16_x5_y8_patient493_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 20614.1, + "Num Detections": 20500, + "Num Negative": 16759, + "Num Positive": 3741, + "Positive %": 18.25, + "Num Positive per mm^2": 1642.2 + } +} \ No newline at end of file diff --git a/493/TumorCenter_CD8_block16_x6_y8_patient493_1.json b/493/TumorCenter_CD8_block16_x6_y8_patient493_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a3d07afd2dab7a686e3b0f53a4c62901b9de2626 --- /dev/null +++ b/493/TumorCenter_CD8_block16_x6_y8_patient493_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 20639.1, + "Num Detections": 20458, + "Num Negative": 17035, + "Num Positive": 3423, + "Positive %": 16.73, + "Num Positive per mm^2": 1445.3 + } +} \ No newline at end of file diff --git a/493/history_text.txt b/493/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..25932da5109ede3ec4f2bb3674ab304970db66ad --- /dev/null +++ b/493/history_text.txt @@ -0,0 +1 @@ +In the patient, a squamous cell carcinoma of the left edge of the tongue had been histologically confirmed externally. The sonographic examination revealed a cN2b neck status. Therefore, the indication for the above-mentioned procedure was given. \ No newline at end of file diff --git a/493/icd_codes.txt b/493/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb81590de3ce161665750de0e1ae957661869a41 --- /dev/null +++ b/493/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] Zungenrandkarzinom[C02.1 ] \ No newline at end of file diff --git a/493/ops_codes.txt b/493/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a75dc535346f1aede93b50042a6b1ac6313884bc --- /dev/null +++ b/493/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] PEG-Sonde Anlage[5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Elektrokoagulation Zungengewebe[5-250.30 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/493/patient_clinical_data.json b/493/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e2573f153a612e77b87753712990e4960f5ed29d --- /dev/null +++ b/493/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 50, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/493/patient_pathological_data.json b/493/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..af489e218deb19b04a3d383406adb6b452ed8214 --- /dev/null +++ b/493/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "493", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/493/surgery_description.txt b/493/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..278e6b7e7d0e179aa3737ecef5d16dd890ef098b --- /dev/null +++ b/493/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Bilateral neck dissection, PEG placement diff --git a/493/surgery_report.txt b/493/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e853c240b9a7b620367235a3c57adced973fefff --- /dev/null +++ b/493/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, first nasotracheal intubation by the anesthesia colleagues. Now intubation with the small bore tube. Inspection of the hypopharynx on both sides, the endolarynx, the epiglottis and the vallecula. Inconspicuous mucosal conditions everywhere. Now enter with the esophagoscope under constant air insufflation into the stomach. Inversion. Inconspicuous mucosal conditions here. Subtle redness. After a positive diaphanoscopy, a PEG tube was inserted without any problems using the thread pull-through method. Now insertion of the thread-reinforced mouth guard. Tightening of the tongue. The tumor described above can be seen in the area of the left edge of the tongue with a central ulcer. This lump is now carefully surrounded with the electric needle, bipolar coagulation and the pointed scissors and successively removed. This creates a relatively large defect in the area of the left tongue. Finally, the tumor can be removed macroscopically on all sides far into the healthy tissue. The tumor is thread-marked for frozen section diagnostics. This reveals tumor cell extensions in the area of the anterior specimen and cranially. A large resection is therefore taken from this area. This specimen is sent for urgent histology. Subsequently, marginal samples are taken and sent for frozen section diagnostics, where they are declared tumor-free. An R0 resection can therefore be assumed. Careful hemostasis with bipolar forceps. The result is a relatively large defect in the area of the left edge of the tongue and the floor of the mouth. Further procedure depending on the healing process. Now turn to neck dissection on both sides. Sterile wiping and covering. Infiltration anesthesia with 10 ml xylocaine with adrenaline in each case in the area of the sternocleidomastoid anterior edge. Start on the right side. Dissection through the subcutaneous tissue. Exposure of the platysma. Creation of a small platysma flap. Exposure of the sternocleidomastoid and its anterior edge. Exposure and sparing of the accessorius nerve. Exposure of the omohyoid muscle and the digastric muscle. Exposure of the internal jugular vein and the cervical vascular sheath with carotid and vagus nerve. Protect these structures. Careful dissection along the jugular vein and removal of the posterior neck specimen. This works very well. Now remove the anterior neck specimen with the glandular capsule. No further conspicuous nodules can be seen. All important vessels, such as the jugular vein or superior thyroid vein, can be spared. Now turn to the left side. Skin incision here too. Dissection through the subcutaneous tissue and the platysma. Creation of a platysmal flap. Expose the anterior edge of the sternocleidomastoid. Dissection on the accessorius nerve. Exposure of the digastric muscle and the omohyoid muscle. Dissection along these muscles. Exposure of the submandibular gland. Removal of the capsule. Careful removal of the lateral neck preparation while protecting the plexus branches. This is very successful. Several nodes can be palpated here, all of which are removed. Careful dissection in the area of the anterior neck preparation and removal of the soft tissue here too. Careful bipolar hemostasis. Exposure and sparing of the hypoglossal muscle on both sides. Bipolar hemostasis. Irrigation of the neck wound area on both sides with H2O2 and Ringer's solution. Insertion of a Redon drain. Two-layer wound closure. Application of a pressure bandage. Completion of the procedure without complications. Further procedure after receipt of the final histology. The patient received 3 g Unacid once intraoperatively. Conclusion: Overall enoral resection of a cT2 tongue margin carcinoma on the left. Based on the frozen section diagnosis, an R0 situation can be assumed. Further procedure after receipt of the final histology and function. \ No newline at end of file diff --git a/494/InvasionFront_CD3_block15_x5_y3_patient494_0.json b/494/InvasionFront_CD3_block15_x5_y3_patient494_0.json new file mode 100644 index 0000000000000000000000000000000000000000..32a7312fcf5c9ff32bd52b4e085c12dd822c6f61 --- /dev/null +++ b/494/InvasionFront_CD3_block15_x5_y3_patient494_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17815.6, + "Centroid Y µm": 17165.9, + "Num Detections": 22391, + "Num Negative": 22317, + "Num Positive": 74, + "Positive %": 0.3305, + "Num Positive per mm^2": 27.15 + } +} \ No newline at end of file diff --git a/494/InvasionFront_CD3_block15_x6_y3_patient494_1.json b/494/InvasionFront_CD3_block15_x6_y3_patient494_1.json new file mode 100644 index 0000000000000000000000000000000000000000..310cb1e6f6c1caa1401d765fa27ed7779a6a214c --- /dev/null +++ b/494/InvasionFront_CD3_block15_x6_y3_patient494_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20414.2, + "Centroid Y µm": 16991.0, + "Num Detections": 19746, + "Num Negative": 19686, + "Num Positive": 60, + "Positive %": 0.3039, + "Num Positive per mm^2": 22.63 + } +} \ No newline at end of file diff --git a/494/InvasionFront_CD8_block15_x5_y3_patient494_0.json b/494/InvasionFront_CD8_block15_x5_y3_patient494_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1be4858e75d330a7fafc1fc4912d9720d8ce7aa1 --- /dev/null +++ b/494/InvasionFront_CD8_block15_x5_y3_patient494_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16081.3, + "Centroid Y µm": 7174.1, + "Num Detections": 19454, + "Num Negative": 19347, + "Num Positive": 107, + "Positive %": 0.55, + "Num Positive per mm^2": 41.68 + } +} \ No newline at end of file diff --git a/494/InvasionFront_CD8_block15_x6_y3_patient494_1.json b/494/InvasionFront_CD8_block15_x6_y3_patient494_1.json new file mode 100644 index 0000000000000000000000000000000000000000..75a15f861c0465b8ed1de0560c0415e81f790df3 --- /dev/null +++ b/494/InvasionFront_CD8_block15_x6_y3_patient494_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18707.7, + "Centroid Y µm": 7147.0, + "Num Detections": 16489, + "Num Negative": 16392, + "Num Positive": 97, + "Positive %": 0.5883, + "Num Positive per mm^2": 41.33 + } +} \ No newline at end of file diff --git a/494/TumorCenter_CD3_block15_x5_y3_patient494_0.json b/494/TumorCenter_CD3_block15_x5_y3_patient494_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08a94d3b0015ba9e4ea4ead1aa97d38da8963016 --- /dev/null +++ b/494/TumorCenter_CD3_block15_x5_y3_patient494_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 10794.3, + "Num Detections": 21385, + "Num Negative": 21359, + "Num Positive": 26, + "Positive %": 0.1216, + "Num Positive per mm^2": 9.921 + } +} \ No newline at end of file diff --git a/494/TumorCenter_CD3_block15_x6_y3_patient494_1.json b/494/TumorCenter_CD3_block15_x6_y3_patient494_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6a6e8995f94357acf7cf74e7f21effb5a116c358 --- /dev/null +++ b/494/TumorCenter_CD3_block15_x6_y3_patient494_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 10769.3, + "Num Detections": 22505, + "Num Negative": 22488, + "Num Positive": 17, + "Positive %": 0.0755, + "Num Positive per mm^2": 6.638 + } +} \ No newline at end of file diff --git a/494/TumorCenter_CD8_block15_x5_y3_patient494_0.json b/494/TumorCenter_CD8_block15_x5_y3_patient494_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7d18be8a10196c6214449efff7e704586139a2ea --- /dev/null +++ b/494/TumorCenter_CD8_block15_x5_y3_patient494_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 7421.1, + "Num Detections": 20319, + "Num Negative": 20258, + "Num Positive": 61, + "Positive %": 0.3002, + "Num Positive per mm^2": 23.54 + } +} \ No newline at end of file diff --git a/494/TumorCenter_CD8_block15_x6_y3_patient494_1.json b/494/TumorCenter_CD8_block15_x6_y3_patient494_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f2796c7a3973f06abd6c0fb0441945c72a85d7b --- /dev/null +++ b/494/TumorCenter_CD8_block15_x6_y3_patient494_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21438.6, + "Centroid Y µm": 7396.1, + "Num Detections": 21760, + "Num Negative": 21726, + "Num Positive": 34, + "Positive %": 0.1562, + "Num Positive per mm^2": 13.52 + } +} \ No newline at end of file diff --git a/494/history_text.txt b/494/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..78d6572f1dd805a9a0b15694621199047bac4c2e --- /dev/null +++ b/494/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tongue carcinoma. Clinically and on CT, a tumor infiltrating the front 2/3 of the tongue, including the external tongue muscles, extending just above the midline to the right. Overall cT3-4 findings. Findings confirmed by pharyngoscopy. \ No newline at end of file diff --git a/494/icd_codes.txt b/494/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..690584981b660e601dfb869b1c4b276e542a07ed --- /dev/null +++ b/494/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zunge, mehrere Teilbereiche überlappend[C02.8 ] \ No newline at end of file diff --git a/494/ops_codes.txt b/494/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..48a63639428dc19484db41dbc2a468508d06b5e9 --- /dev/null +++ b/494/ops_codes.txt @@ -0,0 +1 @@ +Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Temporäre Tracheotomie[5-311.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Selektive Neck dissection in 4 Regionen[5-403.03 L] Selektive Neck dissection in 3 Regionen[5-403.02 R] Transorale partielle Zungenamputation mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Entnahme eines freien Lappens am Unterarm mit mikrovaskulärer Anastomosierung[5-904.08 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 Transorale Resektion des Mundbodens mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-277.02 ] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/494/patient_clinical_data.json b/494/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1b029b783bc39b0d8735d060b1734cd34180ed3a --- /dev/null +++ b/494/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/494/patient_pathological_data.json b/494/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d6d75adea97f1ca77f50bbdbaab67278a34f2c11 --- /dev/null +++ b/494/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "494", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/494/surgery_description.txt b/494/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..48a3025dda985cf1dcc312482ee8a3100506a8e8 --- /dev/null +++ b/494/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Neck dissection, and PEG placement diff --git a/494/surgery_report.txt b/494/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b10791b780d5cbf8a7b3b57ffc50968499ce4b6 --- /dev/null +++ b/494/surgery_report.txt @@ -0,0 +1 @@ +This is followed by the PEG insertion. Insertion of the esophagoscope into the stomach. There, during spontaneous diaphanoscopy, insertion of a 15 mm abdominal wall probe without complications. Fixation to the abdominal wall in the typical manner. Subsequent transoral tumor resection: tumor is resected on all sides with a safety margin of 1-1.5 cm. Half the tongue is removed. The floor of the mouth is also resected across the midline in the area of the caruncle to the right. The body of the tongue is resected beyond the midline to the right. Resection extends deep into the base of the tongue and also includes parts of the glossoalveolar groove and the beginning of the pharyngeal wall. The lingual nerve is also resected. A. lingualis is ligated. The preparation is thread-marked for the frozen section. No tumor formations in the area of the mucosal margins. In the resection margin basal to medial lateral scarce resection margins, therefore an extended resection of the remaining muscles of the floor of the mouth, external tongue muscles, tongue base muscles and also muscles from the opposite side is obtained. The specimen is suture-marked (sutures remote from the tumor) and sent for frozen section, where there are no more tumor infiltrates. Thus R0 resection. Subsequent repositioning and sterile draping of all surgical areas. Neck dissection left: Skin incision in typical manner. Exposure of the sternocleidomastoid anterior margin. Exposure of omohyoid muscle, digastric muscle. Exposure of the internal jugular vein, internal carotid artery, external carotid artery, superior thyroid artery. N. vagus is visualized as well as N. accessorius and N. hypoglossus. In the cranial area level II a bulging mass. This shows secretions similar to a neck cyst. No definite lymph node metastasis. Level II-V is evacuated in a typical manner and the branches of the cervical plexus are also preserved. Careful hemostasis. Exposure and preservation of the facial artery from below. The external jugular vein is separated cranially and initially ligated and preserved. Neck dissection on the right is then performed in the same way. Here level II-V evacuation by . Subsequent tracheotomy by and . Small Kocher's collar incision. Exposure of the infrahyoid musculature. Splitting of these. Exposure of the thyroid isthmus, undercutting of this, clamping, severing and treatment using puncture ligatures. Subsequent visualization of the trachea. Entering the 2nd/3rd intercartilaginous space. Creation of a modified Björk flap with a wide base. This is epithelized in the typical manner. Subsequently reintubation and insertion of a size 8 tracheal tube, which is fixed with sutures. Then after measuring the defect, which is 11 x 6-7 cm. Mark the size and shape of the flap on the left forearm. Then first lift the flap subfascially from the ulnar side. Then extend the incision into the crook of the elbow. Expose the superficial venous system and connection to the deep venous system. Subfascial elevation of the superficial venous system. Subsequent elevation of the flap subfascially from the radial side. Exposure and preservation of the lateral antebrachial cutaneous nerve. Subsequent exposure of the radial artery. After clamping and waiting, no change in the saturation of the hand, which is always 100% in this case. Deposition of the radial artery. Successive elevation of the radial artery flap with ligation or bipolar coagulation or clipping of vessels. The vascular pedicle is dissected up to the antecubital fossa. Good confluence can be visualized here. Connection to the superficial venous system. A large cephalic vein with ends on the superficial venous system. Finally, the flap is removed. Veins are ligated. Confluence is additionally clipped. The interosseous artery is clipped after waiting for saturation. The radial artery is treated at the entrance to the brachial artery using 6-0 Vascufil sutures. The flap is flushed with heparin and preserved. In the forearm, after extensive hemostasis, the skin is first closed proximally in the typical manner and a Redon drain is inserted. A piece of split skin is then removed from the thigh with the dermatome in the typical manner. Hydrocolloid dressing is then applied. Split skin is worked into the defect. Here complete tension-free defect coverage. Relief incisions. Application of swabs. Application of octenidine gel and Mepilex. The arm is then covered with compresses and wrapped in absorbent cotton. Application and fitting of a Cramer splint. This is fixed in a functional position with a tape bandage. Hand is in 100% saturation. Subsequent positioning of the arm. Radialis flap is successively worked into the defect with 3-0 Vicryl single button sutures. The pedicle is inserted anteriorly in the area of the defect. The digastric muscles were also cut from below. Other parts of the muscles of the floor of the mouth, including the submandibular gland, were also removed to enlarge the tunnel. The submandibular gland was removed because the sublingual gland and the entire wharton's duct were also resected, as was the lingual nerve. All removed parts of the floor of the mouth muscles and the submandibular gland are preserved and sent for histology as another final marginal sample. The mucosa in the right floor of the mouth area is incised and the Wharton's duct is incised and marsupialized. The flap is sutured over here in the typical manner. After the flap has been completely sutured without tension and the pedicle has been passed into the soft tissues of the neck, the facial artery is selected, as the lumen of the superior thyroid artery is too small for connection to the radial artery. The radial artery is anastomosed with the facial artery after conditioning with single 9-button Ethilon sutures. Opening of the clamps, good arterial flow, good venous return. The V. thyroidea media and a further outlet for the venous anastomosis are then prepared and conditioned, as are the V. cephalica and an outlet of the confluence. After conditioning, the confluence is anastomosed to the small outlet from the V. thyroidea media using a 1.5 mm coupler. After opening the clamps, good venous return, positive smear phenomenon. The larger outlet from the V. thyroidea media is then anastomosed with the V. cephalica using a 2.5 mm coupler. Again, good venous return after opening the vein. Positive smear phenomenon. Subsequent careful irrigation of the wound area. Careful hemostasis. Layered wound closure on the left with 2 flaps. Skin closure on the right in the neck area with insertion of a Redon drainage. Check the flap again, it is well perfused. Severe swelling in the mouth area. Patient goes to the intensive care unit postoperatively ventilated. Please continue antibiotic treatment with Unacid, which was started intraoperatively, for one week. Nutrition via the inserted PEG tube. This should be loosened the following day. Thereafter, if necessary, nutrition via the PEG tube. Food build-up after 7-10 days at the earliest, depending on the flap situation. If necessary, swallow porridge. Check the flap transorally. A suture marker is placed for Doppler control. Check the flap according to the schedule for 5 days. Heparin perfusor 500 E/h was started intraoperatively, please continue this for 5 days. Overall cT3-4 carcinoma of the floor of the tongue extending into the base of the tongue. Defect covered by radial flap. The left cervical mass in level II may be a neck cyst or a lymph node metastasis with necrotic contents. In this case, however, the macroscopic aspect is atypical. Presentation after receipt of the final histology in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/495/InvasionFront_CD3_block18_x5_y1_patient495_0.json b/495/InvasionFront_CD3_block18_x5_y1_patient495_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5047ad3c4bc125a0b6f9b7bbe8f98a27a150f540 --- /dev/null +++ b/495/InvasionFront_CD3_block18_x5_y1_patient495_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 7296.1, + "Num Detections": 19217, + "Num Negative": 15755, + "Num Positive": 3462, + "Positive %": 18.02, + "Num Positive per mm^2": 1642.3 + } +} \ No newline at end of file diff --git a/495/InvasionFront_CD3_block18_x6_y1_patient495_1.json b/495/InvasionFront_CD3_block18_x6_y1_patient495_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f97f772706d96fb582c9645f9b0e4de03090ffae --- /dev/null +++ b/495/InvasionFront_CD3_block18_x6_y1_patient495_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19539.7, + "Centroid Y µm": 7371.1, + "Num Detections": 16554, + "Num Negative": 13963, + "Num Positive": 2591, + "Positive %": 15.65, + "Num Positive per mm^2": 1235.0 + } +} \ No newline at end of file diff --git a/495/InvasionFront_CD8_block18_x5_y1_patient495_0.json b/495/InvasionFront_CD8_block18_x5_y1_patient495_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4ca6182ac2ca5a9037a3ee373d195df562f7ed2c --- /dev/null +++ b/495/InvasionFront_CD8_block18_x5_y1_patient495_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 10819.3, + "Num Detections": 18018, + "Num Negative": 10877, + "Num Positive": 7141, + "Positive %": 39.63, + "Num Positive per mm^2": 3414.2 + } +} \ No newline at end of file diff --git a/495/InvasionFront_CD8_block18_x6_y1_patient495_1.json b/495/InvasionFront_CD8_block18_x6_y1_patient495_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cc04961666d35c5b7fed3f316151b68de2abb1cc --- /dev/null +++ b/495/InvasionFront_CD8_block18_x6_y1_patient495_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 10919.2, + "Num Detections": 16234, + "Num Negative": 10865, + "Num Positive": 5369, + "Positive %": 33.07, + "Num Positive per mm^2": 2700.0 + } +} \ No newline at end of file diff --git a/495/TumorCenter_CD3_block18_x5_y1_patient495_0.json b/495/TumorCenter_CD3_block18_x5_y1_patient495_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1fb122ebf16c6906b0950e9241d41be2af24d618 --- /dev/null +++ b/495/TumorCenter_CD3_block18_x5_y1_patient495_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 2673.4, + "Num Detections": 13532, + "Num Negative": 13270, + "Num Positive": 262, + "Positive %": 1.936, + "Num Positive per mm^2": 149.69 + } +} \ No newline at end of file diff --git a/495/TumorCenter_CD3_block18_x6_y1_patient495_1.json b/495/TumorCenter_CD3_block18_x6_y1_patient495_1.json new file mode 100644 index 0000000000000000000000000000000000000000..abad34215ce9a0a5c15cf07a34ee22b48d2f2c12 --- /dev/null +++ b/495/TumorCenter_CD3_block18_x6_y1_patient495_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 2773.4, + "Num Detections": 12937, + "Num Negative": 12628, + "Num Positive": 309, + "Positive %": 2.388, + "Num Positive per mm^2": 179.25 + } +} \ No newline at end of file diff --git a/495/TumorCenter_CD8_block18_x5_y1_patient495_0.json b/495/TumorCenter_CD8_block18_x5_y1_patient495_0.json new file mode 100644 index 0000000000000000000000000000000000000000..87147e027518d45b50e065fa00247febb3687e43 --- /dev/null +++ b/495/TumorCenter_CD8_block18_x5_y1_patient495_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 3198.3, + "Num Detections": 13854, + "Num Negative": 11794, + "Num Positive": 2060, + "Positive %": 14.87, + "Num Positive per mm^2": 1107.4 + } +} \ No newline at end of file diff --git a/495/TumorCenter_CD8_block18_x6_y1_patient495_1.json b/495/TumorCenter_CD8_block18_x6_y1_patient495_1.json new file mode 100644 index 0000000000000000000000000000000000000000..df78cb4999ea8495e385d79415c3d1a8a09b6a7c --- /dev/null +++ b/495/TumorCenter_CD8_block18_x6_y1_patient495_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18515.2, + "Centroid Y µm": 3173.3, + "Num Detections": 13361, + "Num Negative": 11360, + "Num Positive": 2001, + "Positive %": 14.98, + "Num Positive per mm^2": 1073.8 + } +} \ No newline at end of file diff --git a/495/history_text.txt b/495/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/495/icd_codes.txt b/495/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8eb6cd7fac5c3b99c69823658dd38a1c2ee7589f --- /dev/null +++ b/495/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 L] \ No newline at end of file diff --git a/495/ops_codes.txt b/495/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c13a662f476cb71b4d840289ae8bd6b5362d915 --- /dev/null +++ b/495/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/495/patient_clinical_data.json b/495/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2a91245e207d3ef987504eef984a6f59e0a06566 --- /dev/null +++ b/495/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/495/patient_pathological_data.json b/495/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b0565b7d34efc225fe36c4723d1672c5fe34dd27 --- /dev/null +++ b/495/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "495", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 51, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/495/surgery_description.txt b/495/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bb0bd1a1201eee5c4987929fcb41acc71b3734b0 --- /dev/null +++ b/495/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, PEG placement diff --git a/495/surgery_report.txt b/495/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d5317870817c9f155adc68689b8b15e5087657a4 --- /dev/null +++ b/495/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater. Introductory consultation with the anesthesia colleagues and implementation of the team time-out. Induction of intubation anesthesia by colleagues. First start of PEG insertion, for this purpose pre-mirroring with the flexible gastroesophagoscope into the stomach. Locate the anterior wall of the stomach and perform a positive diaphanoscopy. The PEG tube is then inserted in the usual way using the thread pull-through method. Now carefully mirror back. Inspection of the surgical site from the endolaryngeal side with the Kleinsasser tube: This shows a tumorous mass purely endolaryngeal in the area of the left aryepiglottic fold and the left pocket fold extending onto the glottis. The posterior surface of the aryepiglottic fold and the postcricoid region as well as the piriform sinus on the right and left side and the base of the tongue are tumor-free. To be on the safe side, a sample is taken from the base of the tongue and sent for frozen section diagnostics. No tumor infiltration after feedback. The laryngectomy is then started by creating an apron flap. To do this, mark the skin incision on the anterior edge of the sternocleidomastoid on both sides to below the cricoid, extending centrally to the cervix. Separation of the cutaneous-subcutaneous tissue and the platysma. Subplatysmal flap preparation and suturing of the flap at the level of the hyoid bone. Now proceed in parallel on both sides. Neck dissection on the right side. For this, dissect along the sternocleidomastoid muscle to the deep cervical fascia. Here the accessory nerve is exposed and freed from the neck preparation. Expose the digastric muscle at the cranial border and follow the muscle to the hyoid bone. Now identify the omohyoid muscle and dissect along the muscle to the hyoid bone. The neck resectate is carefully detached from the cervical vascular nerve sheath. Now remove the neck dissectate region II to V from cranial to caudal in one piece. Subtle hemostasis using bipolar coagulation forceps and completion of the neck dissection on the right side without complications. The accessorius nerve and all other nerve and vascular structures were preserved. Now the same procedure on the left side. There were also no abnormalities during the dissection. Now freeing of the larynx after performing the tracheotomy in the 2nd to 3rd intertracheal space. Free preparation of the laryngeal skeleton from the thyroid gland. The cervical vascular nerve sheath is also freed from the laryngeal skeleton on both sides. For this purpose, the artery and the superior laryngeal nerve are ligated and clamped on both sides. Dissection of the hyoid bone with the harmonic knife. To do this, detach the suprahyoid and infrahyoid muscles. The hypoglossal nerve can be exposed on both sides of the upper edge of the hyoid bone and safely protected. After resection of the hyoid bone, sharp entry into the base of the tongue just above the epiglottis. Due to the supraglottic extension, it is decided not to dissect the epiglottis sharply. Identification of the epiglottis and dislocation. It becomes apparent that the tumor has a purely endolaryngeal extension that does not extend beyond the aryepiglottic fold or the epiglottis. The tip of the epiglottis is free of tumor. Now carefully dissect along the aryepiglottic fold. For this purpose, a greater distance is used on the left side (tumor side) than on the right side (in the usual manner). Unite the incision postcricoidally and extirpate the larynx while sparing the mucosa of the hypopharynx. The piriform sinus can be easily detached from the thyroid cartilage on both sides and protected. After removal of the larynx, obtain 6 marginal samples (postcricoid, left inferior and superior hypopharynx, right inferior and superior hypopharynx, base of tongue). The tissue samples obtained are sent for frozen section diagnostic evaluation. After feedback, all marginal samples are free. Perform a myotomy of the inferior constrictor pharyngeal muscle. Insertion of a provox prosthesis in the usual manner. Then two-layer pharyngeal suture using a continuous inverted suture and placement of a T-suture. A second single button suture is placed over this to protect it. Incision of the tracheostoma, placement of two Redonda sutures and two-layer wound closure using subcutaneous/cutaneous sutures. \ No newline at end of file diff --git a/496/InvasionFront_CD3_block13_x5_y11_patient496_0.json b/496/InvasionFront_CD3_block13_x5_y11_patient496_0.json new file mode 100644 index 0000000000000000000000000000000000000000..50e56d5f9de03cb3b316c1b7d89ab33ba28938ec --- /dev/null +++ b/496/InvasionFront_CD3_block13_x5_y11_patient496_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 26511.0, + "Num Detections": 19319, + "Num Negative": 17594, + "Num Positive": 1725, + "Positive %": 8.929, + "Num Positive per mm^2": 724.06 + } +} \ No newline at end of file diff --git a/496/InvasionFront_CD3_block13_x6_y11_patient496_1.json b/496/InvasionFront_CD3_block13_x6_y11_patient496_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a72354a6b0a85c97333eb35a5c3c4c7ce3f60454 --- /dev/null +++ b/496/InvasionFront_CD3_block13_x6_y11_patient496_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 26511.0, + "Num Detections": 19341, + "Num Negative": 18476, + "Num Positive": 865, + "Positive %": 4.472, + "Num Positive per mm^2": 355.46 + } +} \ No newline at end of file diff --git a/496/InvasionFront_CD8_block13_x5_y11_patient496_0.json b/496/InvasionFront_CD8_block13_x5_y11_patient496_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9e8d0d12fc40805c7995582da61b3bcba6e402e1 --- /dev/null +++ b/496/InvasionFront_CD8_block13_x5_y11_patient496_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 28684.8, + "Num Detections": 16653, + "Num Negative": 14274, + "Num Positive": 2379, + "Positive %": 14.29, + "Num Positive per mm^2": 1163.1 + } +} \ No newline at end of file diff --git a/496/InvasionFront_CD8_block13_x6_y11_patient496_1.json b/496/InvasionFront_CD8_block13_x6_y11_patient496_1.json new file mode 100644 index 0000000000000000000000000000000000000000..71455d7ac2ce3d73cf8b989cafcef9677bdd87f5 --- /dev/null +++ b/496/InvasionFront_CD8_block13_x6_y11_patient496_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 28959.7, + "Num Detections": 16293, + "Num Negative": 14918, + "Num Positive": 1375, + "Positive %": 8.439, + "Num Positive per mm^2": 666.01 + } +} \ No newline at end of file diff --git a/496/TumorCenter_CD3_block13_x5_y11_patient496_0.json b/496/TumorCenter_CD3_block13_x5_y11_patient496_0.json new file mode 100644 index 0000000000000000000000000000000000000000..663346b03110a4def078944c0222e574e0eef7de --- /dev/null +++ b/496/TumorCenter_CD3_block13_x5_y11_patient496_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 34206.9, + "Num Detections": 18276, + "Num Negative": 17114, + "Num Positive": 1162, + "Positive %": 6.358, + "Num Positive per mm^2": 515.61 + } +} \ No newline at end of file diff --git a/496/TumorCenter_CD3_block13_x6_y11_patient496_1.json b/496/TumorCenter_CD3_block13_x6_y11_patient496_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b51db5daf912db50423e980b42d4cf6b21bab8a9 --- /dev/null +++ b/496/TumorCenter_CD3_block13_x6_y11_patient496_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 34381.8, + "Num Detections": 15721, + "Num Negative": 13139, + "Num Positive": 2582, + "Positive %": 16.42, + "Num Positive per mm^2": 1170.7 + } +} \ No newline at end of file diff --git a/496/TumorCenter_CD8_block13_x5_y11_patient496_0.json b/496/TumorCenter_CD8_block13_x5_y11_patient496_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f722e0e4bd7aa090b32ba3bb815a1dc799e681e3 --- /dev/null +++ b/496/TumorCenter_CD8_block13_x5_y11_patient496_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 26535.9, + "Num Detections": 19349, + "Num Negative": 18502, + "Num Positive": 847, + "Positive %": 4.377, + "Num Positive per mm^2": 390.16 + } +} \ No newline at end of file diff --git a/496/TumorCenter_CD8_block13_x6_y11_patient496_1.json b/496/TumorCenter_CD8_block13_x6_y11_patient496_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9a33063b6ffd5a98ac2fd3c14f52a7efae79d446 --- /dev/null +++ b/496/TumorCenter_CD8_block13_x6_y11_patient496_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20789.0, + "Centroid Y µm": 26111.2, + "Num Detections": 21090, + "Num Negative": 18841, + "Num Positive": 2249, + "Positive %": 10.66, + "Num Positive per mm^2": 886.59 + } +} \ No newline at end of file diff --git a/496/history_text.txt b/496/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/496/icd_codes.txt b/496/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/496/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/496/ops_codes.txt b/496/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..41443f65dce40cbe16ec87816b411540fe6a59f3 --- /dev/null +++ b/496/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/496/patient_clinical_data.json b/496/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1e0b3e01198fa7f153181eae6882d2e80040e8ab --- /dev/null +++ b/496/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 77, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/496/patient_pathological_data.json b/496/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..689a4649a3dd20683209356ccd73290dd67a69c5 --- /dev/null +++ b/496/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "496", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/496/surgery_description.txt b/496/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..93119928bb25b9ee223db531cea627294dcf996c --- /dev/null +++ b/496/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy transorally, Panendoscopy, PEG placement diff --git a/496/surgery_report.txt b/496/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4aefc1919b36e42f867b2ec8824a05d06b50866e --- /dev/null +++ b/496/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, the tumor is initially positioned on the right edge of the tongue. Grasp the tongue and resect the tumor successively with the ultrasonic knife. This results in an almost complete hemiglossectomy. In the frozen section histological examination, all tumor margins are found to be at least 0.5 cm in the healthy tissue, so that an R0 resection can be assumed. Careful hemostasis by bipolar coagulation. Re-adaptation of the wound edges with several mattress sutures. Subsequent transition to diagnostic panendoscopy. Hypopharyngoscopy reveals leukoplakic changes except for the left hypopharyngeal side wall at the entrance to the piriform sinus, which are biopsied. These are also without evidence of malignancy on frozen section histology. The larynx and all mirror findings are unremarkable. Subsequent flexible gastroesophagoscopy. No evidence of neoplasia. The esophagus is leukoplakic and vulnerable almost over its entire length, so that a gastroenterological clarification is recommended here. Finally, after obtaining the histology, a transnasal gastric tube is inserted, the position of which is checked by auscultation. Finally, infiltration of the tongue resection with Naropin. Conclusion: Transoral partial glossectomy on the right side for tongue carcinoma. R0 frozen section histology (resection margins greater than or equal to 0.5 cm). Panendoscopy revealed leukoplakic changes in the left hypopharyngeal side wall and along almost the entire length of the esophagus. Therefore enterologic clarification recommended. \ No newline at end of file diff --git a/497/InvasionFront_CD3_block11_x3_y6_patient497_0.json b/497/InvasionFront_CD3_block11_x3_y6_patient497_0.json new file mode 100644 index 0000000000000000000000000000000000000000..38c448344a4d430242bb9d5e528729bee3cb43c1 --- /dev/null +++ b/497/InvasionFront_CD3_block11_x3_y6_patient497_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10619.4, + "Centroid Y µm": 14717.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/497/InvasionFront_CD3_block11_x4_y6_patient497_1.json b/497/InvasionFront_CD3_block11_x4_y6_patient497_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e45bc235f9ef871ffc778e08fd6f6d4cf7daa35b --- /dev/null +++ b/497/InvasionFront_CD3_block11_x4_y6_patient497_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13118.1, + "Centroid Y µm": 14642.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/497/InvasionFront_CD8_block11_x3_y6_patient497_0.json b/497/InvasionFront_CD8_block11_x3_y6_patient497_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cbc380454b2e8f327b3c732ae2ea98567b588c48 --- /dev/null +++ b/497/InvasionFront_CD8_block11_x3_y6_patient497_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13688.2, + "Centroid Y µm": 25626.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/497/InvasionFront_CD8_block11_x4_y6_patient497_1.json b/497/InvasionFront_CD8_block11_x4_y6_patient497_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6b207496a37dcc05168103e3353adec728c84e94 --- /dev/null +++ b/497/InvasionFront_CD8_block11_x4_y6_patient497_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16072.3, + "Centroid Y µm": 25589.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/497/TumorCenter_CD3_block11_x3_y6_patient497_0.json b/497/TumorCenter_CD3_block11_x3_y6_patient497_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a8cf6b8be82d7a3321f8dc529bd191df6619b4e --- /dev/null +++ b/497/TumorCenter_CD3_block11_x3_y6_patient497_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14201.1, + "Centroid Y µm": 14664.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/497/TumorCenter_CD3_block11_x4_y6_patient497_1.json b/497/TumorCenter_CD3_block11_x4_y6_patient497_1.json new file mode 100644 index 0000000000000000000000000000000000000000..88021624e3b1adaaeb4b9548e6cb7741da6aee35 --- /dev/null +++ b/497/TumorCenter_CD3_block11_x4_y6_patient497_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16779.4, + "Centroid Y µm": 14679.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/497/TumorCenter_CD8_block11_x3_y6_patient497_0.json b/497/TumorCenter_CD8_block11_x3_y6_patient497_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c14f356328fd237ffcc0ed7fd0fc2f5d6eadf6ee --- /dev/null +++ b/497/TumorCenter_CD8_block11_x3_y6_patient497_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11568.9, + "Centroid Y µm": 14717.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/497/TumorCenter_CD8_block11_x4_y6_patient497_1.json b/497/TumorCenter_CD8_block11_x4_y6_patient497_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c0b395bbbda864a6c7b3fcb8bca4043ad17f1662 --- /dev/null +++ b/497/TumorCenter_CD8_block11_x4_y6_patient497_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14081.6, + "Centroid Y µm": 14689.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/497/history_text.txt b/497/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/497/icd_codes.txt b/497/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d319480fb2a07ec171cd542ce4e2aa1c382d4a55 --- /dev/null +++ b/497/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] Sekundäre und nicht näher bezeichnete bösartige Neubildung: Lymphknoten des Kopfes, des Gesichtes und des Halses[C77.0 ] \ No newline at end of file diff --git a/497/ops_codes.txt b/497/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5f31f09c3412aed71721ed4cdebb520392bfb7b5 --- /dev/null +++ b/497/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie [ohne Adenotomie] radikal transoral[5-281.2 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] \ No newline at end of file diff --git a/497/patient_clinical_data.json b/497/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..db8d9a5253c284d95a09df13d5f9a37c0ba93b0f --- /dev/null +++ b/497/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 74, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/497/patient_pathological_data.json b/497/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8d3a93b1ea0664c8d18385239a439992c0f81236 --- /dev/null +++ b/497/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "497", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Lymphoepithelial", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/497/surgery_description.txt b/497/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..88335be882dbbe031ace0125961207287e931cd1 --- /dev/null +++ b/497/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy and Right-sided neck dissection diff --git a/497/surgery_report.txt b/497/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2de0b4b97b6685ab369aeff60bdbe14bcccbc5f4 --- /dev/null +++ b/497/surgery_report.txt @@ -0,0 +1 @@ +Tumor resection: The tumor is cut around on all sides with a macroscopically sufficient safety margin and successively dissected away from the pharyngeal musculature. However, similar to an iceberg, this reveals a more significant depth expansion than initially visible macroscopically. In the cranio-lateral region, one has the impression that it has not come off safely in the healthy area. A resection is performed here. Otherwise, the tumor margins are macroscopically clear on all sides, even in depth. Suture marking of the specimen after tumor resection. The specimen is sent together with the resection for final histological examination. Extensive and careful hemostasis in the area of the resection site. After completion of the resection, the oropharynx is inspected again. Dry conditions prevail here. Insertion of a feeding tube. The correct position of the feeding tube is checked using air insufflation. Neck dissection on the right: A curved scar can be seen along the right lateral side of the neck, obviously from the resection of a glomus jugulare tumor. This scar is completely reopened. Sharp transection of the subcutaneous tissue. The sternocleidomastoid muscle cannot be identified. Then, due to the scarring and the altered anatomy, laborious dissection and exposure of the internal jugular vein, the common carotid artery, the vagus nerve, the superior thyroid artery and the digastric muscle. The accessorius nerve cannot be visualized either. The internal jugular vein appears to have been occluded cranially. Multiple pathological lymph nodes can be seen along the cervical vascular sheath, but particularly in region IV and in the deep regions of region V. All pathological lymph nodes are removed while sparing the structures mentioned. A stronger venous vessel with a connection to the internal jugular vein is bypassed caudally. At the end of the operation, after careful hemostasis, dry wound conditions. Extensive wound irrigation with H2O2 and Ringer's solution. Insertion of a Redon drain. Two-layer wound closure. \ No newline at end of file diff --git a/498/InvasionFront_CD3_block16_x1_y2_patient498_0.json b/498/InvasionFront_CD3_block16_x1_y2_patient498_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b491b4edf878ba565f501d14afdd932e76cc7018 --- /dev/null +++ b/498/InvasionFront_CD3_block16_x1_y2_patient498_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4478.2, + "Centroid Y µm": 9444.5, + "Num Detections": 21492, + "Num Negative": 20883, + "Num Positive": 609, + "Positive %": 2.834, + "Num Positive per mm^2": 253.42 + } +} \ No newline at end of file diff --git a/498/InvasionFront_CD3_block16_x2_y2_patient498_1.json b/498/InvasionFront_CD3_block16_x2_y2_patient498_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a8a7b2b69a9190402348924246b19aae47d2527 --- /dev/null +++ b/498/InvasionFront_CD3_block16_x2_y2_patient498_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7276.0, + "Centroid Y µm": 9496.1, + "Num Detections": 19358, + "Num Negative": 18420, + "Num Positive": 938, + "Positive %": 4.846, + "Num Positive per mm^2": 385.89 + } +} \ No newline at end of file diff --git a/498/InvasionFront_CD8_block16_x1_y2_patient498_0.json b/498/InvasionFront_CD8_block16_x1_y2_patient498_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bc57594814e3ba5848ff2f19d2360de1a22fcb13 --- /dev/null +++ b/498/InvasionFront_CD8_block16_x1_y2_patient498_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3847.1, + "Centroid Y µm": 4926.6, + "Num Detections": 22706, + "Num Negative": 21747, + "Num Positive": 959, + "Positive %": 4.224, + "Num Positive per mm^2": 382.75 + } +} \ No newline at end of file diff --git a/498/InvasionFront_CD8_block16_x2_y2_patient498_1.json b/498/InvasionFront_CD8_block16_x2_y2_patient498_1.json new file mode 100644 index 0000000000000000000000000000000000000000..22888fd19d2f6a9b79a5f5c69d9224a7aa3576ca --- /dev/null +++ b/498/InvasionFront_CD8_block16_x2_y2_patient498_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6502.8, + "Centroid Y µm": 4977.1, + "Num Detections": 20882, + "Num Negative": 20147, + "Num Positive": 735, + "Positive %": 3.52, + "Num Positive per mm^2": 297.1 + } +} \ No newline at end of file diff --git a/498/TumorCenter_CD3_block16_x1_y2_patient498_0.json b/498/TumorCenter_CD3_block16_x1_y2_patient498_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bbbca20a0c6d4cd09b87054ebb5e6a89e445e477 --- /dev/null +++ b/498/TumorCenter_CD3_block16_x1_y2_patient498_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5047.3, + "Centroid Y µm": 4947.4, + "Num Detections": 21914, + "Num Negative": 21142, + "Num Positive": 772, + "Positive %": 3.523, + "Num Positive per mm^2": 304.29 + } +} \ No newline at end of file diff --git a/498/TumorCenter_CD3_block16_x2_y2_patient498_1.json b/498/TumorCenter_CD3_block16_x2_y2_patient498_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4b5ec51ecc8592af0663d02389d51138ff5d34b8 --- /dev/null +++ b/498/TumorCenter_CD3_block16_x2_y2_patient498_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7546.0, + "Centroid Y µm": 5047.3, + "Num Detections": 20839, + "Num Negative": 20041, + "Num Positive": 798, + "Positive %": 3.829, + "Num Positive per mm^2": 326.47 + } +} \ No newline at end of file diff --git a/498/TumorCenter_CD8_block16_x1_y2_patient498_0.json b/498/TumorCenter_CD8_block16_x1_y2_patient498_0.json new file mode 100644 index 0000000000000000000000000000000000000000..050eef92e1486136c21c975a34bf86780e9d68c6 --- /dev/null +++ b/498/TumorCenter_CD8_block16_x1_y2_patient498_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3573.1, + "Centroid Y µm": 5147.3, + "Num Detections": 23557, + "Num Negative": 23172, + "Num Positive": 385, + "Positive %": 1.634, + "Num Positive per mm^2": 154.92 + } +} \ No newline at end of file diff --git a/498/TumorCenter_CD8_block16_x2_y2_patient498_1.json b/498/TumorCenter_CD8_block16_x2_y2_patient498_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3a805a6a4d17cb9b2309b680952ae6dec97bcd27 --- /dev/null +++ b/498/TumorCenter_CD8_block16_x2_y2_patient498_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 5222.2, + "Num Detections": 23051, + "Num Negative": 22563, + "Num Positive": 488, + "Positive %": 2.117, + "Num Positive per mm^2": 199.25 + } +} \ No newline at end of file diff --git a/498/history_text.txt b/498/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..00ed3b34a1565cfbdc0d8fde0c5b9902ad63c38d --- /dev/null +++ b/498/history_text.txt @@ -0,0 +1 @@ +The patient has a history of esophageal carcinoma and hypopharyngeal carcinoma in 2002 and has had progressive pain in the area of the right edge of the tongue without B-symptoms for approx. 6 weeks. Inspection and palpation revealed a high-grade suspicion of carcinoma of the edge of the tongue on the right so that the above-mentioned operation is indicated. \ No newline at end of file diff --git a/498/icd_codes.txt b/498/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c43d07d381d3289cc8eb9ca255d23ac459632745 --- /dev/null +++ b/498/icd_codes.txt @@ -0,0 +1 @@ +V.a. cT1 cNO Zungenrandkarzinom rechts[C02.1 ] \ No newline at end of file diff --git a/498/ops_codes.txt b/498/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fbf746db52739f13f667a486fb16109e2aa173f0 --- /dev/null +++ b/498/ops_codes.txt @@ -0,0 +1 @@ +Exzisionsbiopsie Zungenrand rechts[1-545.x ] Direkte Hypopharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/498/patient_clinical_data.json b/498/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..41c64a42e9aacafea9d913a2b0b0f6e6953cd50c --- /dev/null +++ b/498/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/498/patient_pathological_data.json b/498/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9fb3e281aee67b6c7bccec10d4f16d3fb6dfff27 --- /dev/null +++ b/498/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "498", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/498/surgery_description.txt b/498/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ab6802cce3ba6d869b2571e7fced1445d1df0d69 --- /dev/null +++ b/498/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy, Panendoscopy diff --git a/498/surgery_report.txt b/498/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fbc5d6f1c7e069574a7691ed32e140de7dad2fab --- /dev/null +++ b/498/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, rigid tracheoscopy with O° optics. This shows the trachea free up to the carina. Then proceed to laryngoscopy. Smooth mucosa on all sides, both vocal folds appear non-irritated, postcricoid region non-irritated. Laryngeal and lingual epiglottis free. Sinus piriformes can be unfolded on both sides, however, on repeated attempts at esophagoscopy finally not passable due to scarring. After consulting , decision not to perform esophagogastroscopy due to increased risk of perforation. Then proceed to inspection and palpation of the oral cavity, floor of the mouth, tongue and tonsil region. Apart from the mass on the right side of the tongue, there are no other abnormalities, so an excisional biopsy is then performed: Fixation of the tip of the tongue with suture and marking of the resection margins with an electric needle. Then proceed to resection. The tumor in the area of the right edge of the tongue is carefully cut around and finally removed with a safety margin. Anterior suture-marked end (long long). Conclusion: Excision biopsy in the area of the right edge of the tongue with transition to the right glossoalveolar groove. Termination of the operation in hemorrhage-free conditions, suspected cT1 cN0 right tongue margin carcinoma. Further procedure after receipt of the final histology and presentation at our interdisciplinary tumor conference. \ No newline at end of file diff --git a/499/InvasionFront_CD3_block17_x5_y3_patient499_0.json b/499/InvasionFront_CD3_block17_x5_y3_patient499_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7efe8cdc8fa26c4d8ba66a447a53536a28e10548 --- /dev/null +++ b/499/InvasionFront_CD3_block17_x5_y3_patient499_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 12643.3, + "Num Detections": 14324, + "Num Negative": 13906, + "Num Positive": 418, + "Positive %": 2.918, + "Num Positive per mm^2": 210.84 + } +} \ No newline at end of file diff --git a/499/InvasionFront_CD3_block17_x6_y3_patient499_1.json b/499/InvasionFront_CD3_block17_x6_y3_patient499_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e119a395ddcbdf9b9c971fab0ab326358aeb48a --- /dev/null +++ b/499/InvasionFront_CD3_block17_x6_y3_patient499_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 12693.3, + "Num Detections": 20544, + "Num Negative": 18907, + "Num Positive": 1637, + "Positive %": 7.968, + "Num Positive per mm^2": 671.19 + } +} \ No newline at end of file diff --git a/499/InvasionFront_CD8_block17_x5_y3_patient499_0.json b/499/InvasionFront_CD8_block17_x5_y3_patient499_0.json new file mode 100644 index 0000000000000000000000000000000000000000..296738c34e5223b4c62e6f6a35ffab4db1b7623b --- /dev/null +++ b/499/InvasionFront_CD8_block17_x5_y3_patient499_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16453.8, + "Centroid Y µm": 7833.4, + "Num Detections": 9820, + "Num Negative": 9715, + "Num Positive": 105, + "Positive %": 1.069, + "Num Positive per mm^2": 75.93 + } +} \ No newline at end of file diff --git a/499/InvasionFront_CD8_block17_x6_y3_patient499_1.json b/499/InvasionFront_CD8_block17_x6_y3_patient499_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dd7482e9ef8028f51f5dbbaeef36ce2dcd143bbe --- /dev/null +++ b/499/InvasionFront_CD8_block17_x6_y3_patient499_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19052.4, + "Centroid Y µm": 7820.9, + "Num Detections": 21617, + "Num Negative": 20708, + "Num Positive": 909, + "Positive %": 4.205, + "Num Positive per mm^2": 379.92 + } +} \ No newline at end of file diff --git a/499/TumorCenter_CD3_block17_x5_y3_patient499_0.json b/499/TumorCenter_CD3_block17_x5_y3_patient499_0.json new file mode 100644 index 0000000000000000000000000000000000000000..258f1f671def902bed8d30323a7c52c66c8b8472 --- /dev/null +++ b/499/TumorCenter_CD3_block17_x5_y3_patient499_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 7471.0, + "Num Detections": 15540, + "Num Negative": 14906, + "Num Positive": 634, + "Positive %": 4.08, + "Num Positive per mm^2": 293.01 + } +} \ No newline at end of file diff --git a/499/TumorCenter_CD3_block17_x6_y3_patient499_1.json b/499/TumorCenter_CD3_block17_x6_y3_patient499_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9026f49a7c4cfff578120d2d4c26e13eec640267 --- /dev/null +++ b/499/TumorCenter_CD3_block17_x6_y3_patient499_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 7571.0, + "Num Detections": 17151, + "Num Negative": 15974, + "Num Positive": 1177, + "Positive %": 6.863, + "Num Positive per mm^2": 566.26 + } +} \ No newline at end of file diff --git a/499/TumorCenter_CD8_block17_x5_y3_patient499_0.json b/499/TumorCenter_CD8_block17_x5_y3_patient499_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3f99cfe06eca731f2779a88857c22ee8c54bda36 --- /dev/null +++ b/499/TumorCenter_CD8_block17_x5_y3_patient499_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 20888.9, + "Num Detections": 13759, + "Num Negative": 13636, + "Num Positive": 123, + "Positive %": 0.894, + "Num Positive per mm^2": 58.58 + } +} \ No newline at end of file diff --git a/499/TumorCenter_CD8_block17_x6_y3_patient499_1.json b/499/TumorCenter_CD8_block17_x6_y3_patient499_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f706c127b910b9c937c551dd0d7931197f87b65c --- /dev/null +++ b/499/TumorCenter_CD8_block17_x6_y3_patient499_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21288.7, + "Centroid Y µm": 21138.8, + "Num Detections": 18786, + "Num Negative": 18320, + "Num Positive": 466, + "Positive %": 2.481, + "Num Positive per mm^2": 215.35 + } +} \ No newline at end of file diff --git a/499/history_text.txt b/499/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..89bf78362aa9c9e87ac80f8ebdd6896287b0a76c --- /dev/null +++ b/499/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma on the right and in situ carcinoma on the left in the anterior region. Removal of the carcinoma by laser or from the outside is now indicated in view of the overall described difficulty of adjustment. \ No newline at end of file diff --git a/499/icd_codes.txt b/499/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/499/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/499/ops_codes.txt b/499/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..349cf7c7607ff28a247e8ea84b89b33f4b830233 --- /dev/null +++ b/499/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] \ No newline at end of file diff --git a/499/patient_clinical_data.json b/499/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..48d95accf10eec0f743b4bf487dadb3869ad1d29 --- /dev/null +++ b/499/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 55, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/499/patient_pathological_data.json b/499/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..85a8fe77cabe66937e53075d93e0731a0f591512 --- /dev/null +++ b/499/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "499", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris1", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/499/surgery_description.txt b/499/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c09b79adb374d30f563900a1da5e57fef5fdc0cb --- /dev/null +++ b/499/surgery_description.txt @@ -0,0 +1 @@ +Laser resection of Glottis carcinoma on the right, SLT (Supraglottic Laryngectomy) stripping for CIS on the left diff --git a/499/surgery_report.txt b/499/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c4a970a995bc5e693565de0e47ee92161f62c0e3 --- /dev/null +++ b/499/surgery_report.txt @@ -0,0 +1 @@ +First of all, the Kleinsasser tube C. Although the tumor is difficult to adjust, it is ultimately adjustable and thus laser resectable when pressure is applied from the outside. The tumor on the right is distended with ingrowth into the laryngeal ventricle. Macroscopically, the left mucosa is rather inconspicuous, no really visible areas of suspicious tumor. Tumor on the right extends to just in front of the arytenoid cartilage and also to just in front of the commissure, which is visible when pressure is applied from the outside. Laser resection of the tumor on the right was therefore performed. Due to the extent and volume of the tumor, it is resected including the vocal cord on the left and the anterior commissure with minor removal of the most anterior parts of the vocal fold, the supraglottic space and the subglottic space on the left. Resection extends laterally to the cartilage, taking the perichondrium with it. The vocal process is also resected dorsally. Caudally, the subglottic slope at a distance of approx. 4-5 mm from the tumor is removed and marked with sutures. A marginal sample is taken subglottically on the right, subglottically in front and supraglottically in front. The mucosa is also removed from the anterior third of the left vocal fold by stripping and also sent in as a marginal sample. In the frozen section, the tumor including the marginal samples is removed in healthy tissue. In the area of the left anterior vocal fold, there is still high-grade dysplasia, but without a visible transition to carcinoma in situ. Nevertheless, due to these findings, the mucosa is also removed in the sense of stripping from the posterior parts of the left vocal fold, including the transition to the morgue ventricle and the subglottic outlet. These mucosal parts are sent in as the final sample. Now most careful hemostasis. No more bleeding at the end of the operation. A tracheotomy can be dispensed with due to the overall situation. Removal of the mouth guard and Kleinsasser tube. Completion of the procedure without complications. Overall cT1-2 glottic carcinoma on the right and carcinoma in situ or high-grade dysplasia on the vocal fold in the mucosal area on the left. Patient received intraoperative and preoperative clindamycin antibiotics. Please continue this antibiotic treatment for one week. It is essential to schedule another MLE check-up in 8-12 weeks. \ No newline at end of file diff --git a/500/InvasionFront_CD3_block10_x3_y3_patient500_0.json b/500/InvasionFront_CD3_block10_x3_y3_patient500_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f7b91007979f241340d8d6f3ed0d0b5631619546 --- /dev/null +++ b/500/InvasionFront_CD3_block10_x3_y3_patient500_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13936.8, + "Centroid Y µm": 12699.3, + "Num Detections": 20407, + "Num Negative": 18308, + "Num Positive": 2099, + "Positive %": 10.29, + "Num Positive per mm^2": 878.45 + } +} \ No newline at end of file diff --git a/500/InvasionFront_CD3_block10_x4_y3_patient500_1.json b/500/InvasionFront_CD3_block10_x4_y3_patient500_1.json new file mode 100644 index 0000000000000000000000000000000000000000..902452acb36ccd271e61d5b56ff3068983638588 --- /dev/null +++ b/500/InvasionFront_CD3_block10_x4_y3_patient500_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16572.6, + "Centroid Y µm": 12917.9, + "Num Detections": 21433, + "Num Negative": 20917, + "Num Positive": 516, + "Positive %": 2.408, + "Num Positive per mm^2": 210.0 + } +} \ No newline at end of file diff --git a/500/InvasionFront_CD8_block10_x3_y3_patient500_0.json b/500/InvasionFront_CD8_block10_x3_y3_patient500_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3fae60d107bf8e2cc9e9c182b088d1b36b022591 --- /dev/null +++ b/500/InvasionFront_CD8_block10_x3_y3_patient500_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12930.7, + "Centroid Y µm": 12943.1, + "Num Detections": 22370, + "Num Negative": 21079, + "Num Positive": 1291, + "Positive %": 5.771, + "Num Positive per mm^2": 534.06 + } +} \ No newline at end of file diff --git a/500/InvasionFront_CD8_block10_x4_y3_patient500_1.json b/500/InvasionFront_CD8_block10_x4_y3_patient500_1.json new file mode 100644 index 0000000000000000000000000000000000000000..14bd1713c94c47f93b3371fec8b47ad45b9cc456 --- /dev/null +++ b/500/InvasionFront_CD8_block10_x4_y3_patient500_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15479.3, + "Centroid Y µm": 13030.6, + "Num Detections": 22048, + "Num Negative": 21668, + "Num Positive": 380, + "Positive %": 1.724, + "Num Positive per mm^2": 159.8 + } +} \ No newline at end of file diff --git a/500/TumorCenter_CD3_block10_x3_y3_patient500_0.json b/500/TumorCenter_CD3_block10_x3_y3_patient500_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b32b7a14735d24d02133cc3c818161f3d682e9ba --- /dev/null +++ b/500/TumorCenter_CD3_block10_x3_y3_patient500_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 7670.9, + "Num Detections": 13851, + "Num Negative": 12291, + "Num Positive": 1560, + "Positive %": 11.26, + "Num Positive per mm^2": 939.58 + } +} \ No newline at end of file diff --git a/500/TumorCenter_CD3_block10_x4_y3_patient500_1.json b/500/TumorCenter_CD3_block10_x4_y3_patient500_1.json new file mode 100644 index 0000000000000000000000000000000000000000..97d0a18291e44703e88e30063f1d349383c8b641 --- /dev/null +++ b/500/TumorCenter_CD3_block10_x4_y3_patient500_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 7421.1, + "Num Detections": 18137, + "Num Negative": 17394, + "Num Positive": 743, + "Positive %": 4.097, + "Num Positive per mm^2": 328.4 + } +} \ No newline at end of file diff --git a/500/TumorCenter_CD8_block10_x3_y3_patient500_0.json b/500/TumorCenter_CD8_block10_x3_y3_patient500_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1c344e5be07001dead98909de8f52012fbd5a6b1 --- /dev/null +++ b/500/TumorCenter_CD8_block10_x3_y3_patient500_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 8070.7, + "Num Detections": 16156, + "Num Negative": 13628, + "Num Positive": 2528, + "Positive %": 15.65, + "Num Positive per mm^2": 1289.5 + } +} \ No newline at end of file diff --git a/500/TumorCenter_CD8_block10_x4_y3_patient500_1.json b/500/TumorCenter_CD8_block10_x4_y3_patient500_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9726564ae5e50d4bd7cf1468ed364d7d0ab2087b --- /dev/null +++ b/500/TumorCenter_CD8_block10_x4_y3_patient500_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13317.9, + "Centroid Y µm": 7895.8, + "Num Detections": 19601, + "Num Negative": 19099, + "Num Positive": 502, + "Positive %": 2.561, + "Num Positive per mm^2": 222.87 + } +} \ No newline at end of file diff --git a/500/history_text.txt b/500/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..779e17faa98f8a223cb4b1d82eb863ccda64b7a8 --- /dev/null +++ b/500/history_text.txt @@ -0,0 +1 @@ +In the patient, a poorly differentiated squamous cell carcinoma in the area of the base of the tongue on the left was histologically confirmed during a panendoscopy <2013>. In the synopsis of the findings cT3 cN2c G3 cM0. In our interdisciplinary tumor conference, the primary surgical procedure was indicated. \ No newline at end of file diff --git a/500/icd_codes.txt b/500/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/500/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/500/ops_codes.txt b/500/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10c699f9a85cbc322342a5d7a3752a0b1b07587e --- /dev/null +++ b/500/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-296.14 ] Hemiglossektomie durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] PEG-Sonde Anlage[5-431.2 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/500/patient_clinical_data.json b/500/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a7c47f24e1c841751e4e2fe7b2b6058c0bbf8fd0 --- /dev/null +++ b/500/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/500/patient_pathological_data.json b/500/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2d38d476a7306e29a330e55b7a63615a9ef0fbe0 --- /dev/null +++ b/500/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "500", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/500/surgery_description.txt b/500/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e43b6c915ac54a10e44d1e034f74436e54416926 --- /dev/null +++ b/500/surgery_description.txt @@ -0,0 +1 @@ +Transorale Tumorresektion mit partieller Pharyngektomie, Neck dissection, Freier Lappen (Radialis) diff --git a/500/surgery_report.txt b/500/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e6a67e32aa1894cd239a21487531fbdac7cf2c17 --- /dev/null +++ b/500/surgery_report.txt @@ -0,0 +1 @@ +After intubation and preparation by the anesthesia colleagues, first inspection and palpation of the primary tumor area. An exulcerated tumor of the left base of the tongue was found, extending into the vallecula and occupying a good half of the base of the tongue, in contact with the epiglottis, extending over the lateral pharyngeal wall in the area of the caudal pole of the tonsil up to the entrance of the piriform sinus. Palpatory clear deep infiltration in the area of the base of the tongue. Due to the deep location of the tumor, indication for a primary transcervical approach. PEG insertion should be performed first. For this purpose, insertion with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach and, with good diaphanoscopy, easy puncture of the stomach and subsequent placement of the PEG tube using the usual thread pull-through method. After positioning the patient, start with the neck dissection on the left side. Submandibular skin incision here. Cut through skin and subcutaneous tissue as well as the platysma. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Clearing of the anterior neck preparation with careful protection of the superior thyroid artery, the cervical artery, the hypoglossal nerve and the facial vein. Level II shows a metastasis measuring approx. 3 cm in the area of the jugulo-facial angle, no surrounding infiltration, the accessorius nerve can be preserved. Clearing of the accessorius triangle and level V with careful protection of the cervical plexus branches. Subsequent resection of the digastric muscle. Exposure of the external carotid arteries and long exposure of the hypoglossal nerve. Release of the pharyngeal side wall against the carotid artery. Subsequent exposure of the hyoid. Entering the pharynx just below the epiglottis. Palpation reveals that the tumor is barely displaceable on the lingual surface of the epiglottis. Therefore resection of the cranial end of the epiglottis by approx. 2/3 of the width. Subtotal resection of the vallecula basally on all sides clearly in the healthy area. Subsequent resection of half of the base of the tongue. A clear safety margin is also maintained here. Resection of the pharyngeal side wall and thus macroscopic in sano removal of the tumor. Macroscopically narrowest point in the area of the pharyngeal side wall, otherwise extensive resection and clear resection distance to the depth on all sides. In the area of the pharyngeal side wall, a marginal specimen is therefore completely imaged in the pharyngeal area. The remaining marginal samples are then removed from the specimen, completely covering it. CIS with a questionable microinvasive component can still be seen in the area of the pharyngeal side wall in otherwise completely tumor- and dysplasia-free marginal samples. Therefore, a resection is performed in the entire area followed by imaging of a marginal sample, which is diagnosed as completely free of dysplasia and tumor. Therefore an overall R0 situation. Measurement of the defect. A defect measuring a total of 12 x 7 cm was found, which extended from the soft palate to the entrance of the piriform sinus, with removal of the vallecula and half of the base of the tongue. The rest of the tongue is regular and well supplied with blood. Turn to the neck dissection of the right side. In principle the same procedure as on the opposite side. Submandibular incision. After cutting through the skin and subcutaneous tissue, expose the bordering muscles. Clear the anterior neck preparation while carefully protecting the superior thyroid artery, the cervical artery and the facial vein. Free preparation of the internal jugular vein. Clearing of the accessorius triangle while carefully protecting the nerve. Subsequent evacuation of level V with careful protection of the cervical plexus branches. This also revealed a clearly suspicious change measuring a good 2.5 cm in the jugulo-facial angle, confirming the overall cN2c neck status. On the opposite side, a metastasis-specific lesion was also removed in toto in the soft tissue on the way to tumor resection. This is followed by careful wound irrigation and, if the wound is dry, insertion of a 10 Redon drain and careful, two-layer wound closure. The plastic tracheostomy is then performed. Horizontal incision below the cricoid cartilage. Cutting through skin and subcutaneous tissue. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. After cutting through the thyroid isthmus, enter between the 1st and 2nd tracheal ring. Perform a visor tracheotomy and suture the trachea to the skin level. Subsequently, easy transfer to a size 8 low-cuff cannula, which is suture-fixed. The radialis graft is then removed from the left forearm. After applying the tourniquet, mark the graft measuring 12 x 7.5 cm in total. Radial exposure of the brachioradialis muscle. Exposure and protection of the superficial radial nerve ramus. Exposure of the distal vascular pedicle and transection of the vascular pedicle. Ulnar dissection of the flexor carpi ulnaris. Strictly subfascial release. Making the extension incision. The cephalic vein lies far dorsally and is therefore not elevated. Stalk preparation in the crook of the elbow. Expose and secure the outlet of the ulnar artery and the common interosseous artery. Exposure of a venous confluence. Subsequent reopening of the tourniquet. Vital graft. Regular blood supply to the hand. Careful hemostasis of the graft and the forearm and removal of the vital graft after ligation and clipping of the supplying vessels. The wound is then closed in two layers in the arm area and the full-thickness skin graft harvested from the groin is then incorporated. This is followed by treatment with a vacuum sealing bandage and application of the Kramer splint in the functional position and repositioning of the arm. To lift the full-thickness skin from the groin on the right. Incision of a piece of skin measuring approx. 14 x 6.5 cm. Strictly cutaneous lifting. Subcutaneous mobilization. Careful hemostasis. Insertion of a 10-gauge Redon drain and careful, two-layer wound closure under moderate tension. Subsequent transcervical insertion of the graft. Overall good fit and intact conditions on all sides. Conditioning of the superior thyroid artery. Perform the arterial anastomosis with 8-0 Ethilon. Immediate correct pedicle position and venous return. Measure a coupler size 3.0 and perform the venous anastomosis with the facial vein using the coupler system. Subsequently, proper graft perfusion and proper pedicle position with positive spreading phenomenon. This is followed by careful wound irrigation, insertion of a 10 Redon drain and careful, two-layer wound closure. Final inspection and completion of the procedure with a vital graft. \ No newline at end of file diff --git a/501/InvasionFront_CD3_block22_x1_y5_patient501_0.json b/501/InvasionFront_CD3_block22_x1_y5_patient501_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4371853a7b0fd845c812ae14388628d2db799ee9 --- /dev/null +++ b/501/InvasionFront_CD3_block22_x1_y5_patient501_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4922.4, + "Centroid Y µm": 23837.4, + "Num Detections": 17353, + "Num Negative": 16287, + "Num Positive": 1066, + "Positive %": 6.143, + "Num Positive per mm^2": 512.35 + } +} \ No newline at end of file diff --git a/501/InvasionFront_CD3_block22_x2_y5_patient501_1.json b/501/InvasionFront_CD3_block22_x2_y5_patient501_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4026c0ce13ed89b20f95ad9cb651f2ab0222d25b --- /dev/null +++ b/501/InvasionFront_CD3_block22_x2_y5_patient501_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7221.2, + "Centroid Y µm": 23812.4, + "Num Detections": 15527, + "Num Negative": 14651, + "Num Positive": 876, + "Positive %": 5.642, + "Num Positive per mm^2": 455.68 + } +} \ No newline at end of file diff --git a/501/InvasionFront_CD8_block22_x1_y5_patient501_0.json b/501/InvasionFront_CD8_block22_x1_y5_patient501_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a70e09876c8c5af80a1bcdb8158e4d1ffac37e3 --- /dev/null +++ b/501/InvasionFront_CD8_block22_x1_y5_patient501_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7210.8, + "Centroid Y µm": 12902.7, + "Num Detections": 16739, + "Num Negative": 16160, + "Num Positive": 579, + "Positive %": 3.459, + "Num Positive per mm^2": 281.89 + } +} \ No newline at end of file diff --git a/501/InvasionFront_CD8_block22_x2_y5_patient501_1.json b/501/InvasionFront_CD8_block22_x2_y5_patient501_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4f74e93e9f95b491658c63d0d8659f5c60fbaecf --- /dev/null +++ b/501/InvasionFront_CD8_block22_x2_y5_patient501_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9548.8, + "Centroid Y µm": 12742.8, + "Num Detections": 14531, + "Num Negative": 14019, + "Num Positive": 512, + "Positive %": 3.524, + "Num Positive per mm^2": 273.35 + } +} \ No newline at end of file diff --git a/501/TumorCenter_CD3_block22_x1_y5_patient501_0.json b/501/TumorCenter_CD3_block22_x1_y5_patient501_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d69ea2cad00b9038303d4c726f0a0a86dcb94b05 --- /dev/null +++ b/501/TumorCenter_CD3_block22_x1_y5_patient501_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4547.6, + "Centroid Y µm": 13055.6, + "Num Detections": 16172, + "Num Negative": 15958, + "Num Positive": 214, + "Positive %": 1.323, + "Num Positive per mm^2": 112.13 + } +} \ No newline at end of file diff --git a/501/TumorCenter_CD3_block22_x2_y5_patient501_1.json b/501/TumorCenter_CD3_block22_x2_y5_patient501_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f68dd874c2e3ddee00e43843fcbd8f7d31786aa3 --- /dev/null +++ b/501/TumorCenter_CD3_block22_x2_y5_patient501_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6996.3, + "Centroid Y µm": 13093.1, + "Num Detections": 10690, + "Num Negative": 10532, + "Num Positive": 158, + "Positive %": 1.478, + "Num Positive per mm^2": 106.45 + } +} \ No newline at end of file diff --git a/501/TumorCenter_CD8_block22_x1_y5_patient501_0.json b/501/TumorCenter_CD8_block22_x1_y5_patient501_0.json new file mode 100644 index 0000000000000000000000000000000000000000..09511a0a255db4a6a9f9ebdfaeaf93a7170ec1e6 --- /dev/null +++ b/501/TumorCenter_CD8_block22_x1_y5_patient501_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6696.5, + "Centroid Y µm": 22088.3, + "Num Detections": 16816, + "Num Negative": 16667, + "Num Positive": 149, + "Positive %": 0.8861, + "Num Positive per mm^2": 75.68 + } +} \ No newline at end of file diff --git a/501/TumorCenter_CD8_block22_x2_y5_patient501_1.json b/501/TumorCenter_CD8_block22_x2_y5_patient501_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e781ac6e9587bdc31f095f5e4f5368b380d819cb --- /dev/null +++ b/501/TumorCenter_CD8_block22_x2_y5_patient501_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9220.1, + "Centroid Y µm": 22038.3, + "Num Detections": 13031, + "Num Negative": 12845, + "Num Positive": 186, + "Positive %": 1.427, + "Num Positive per mm^2": 112.5 + } +} \ No newline at end of file diff --git a/501/history_text.txt b/501/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5bdfaf66e9e00b484cd45588be28f86b31967c7d --- /dev/null +++ b/501/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the right. The above-mentioned surgery was therefore indicated. \ No newline at end of file diff --git a/501/icd_codes.txt b/501/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b2498ce133317ab14574ea0e3579b788b56ad8b --- /dev/null +++ b/501/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] Sekundäre bösartige Neubildung der Halslymphknoten[C77.0 B] \ No newline at end of file diff --git a/501/ops_codes.txt b/501/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a81fa9af27e98093ce66beee5d68d97332b51d0 --- /dev/null +++ b/501/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit gestieltem Fernlappen[5-303.15 ] Permanente Tracheotomie[5-312.0 ] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 6 Regionen[5-403.12 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 4 Regionen[5-403.10 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] \ No newline at end of file diff --git a/501/patient_clinical_data.json b/501/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..51d23075302c1f6f04b9a55f64766e244444483f --- /dev/null +++ b/501/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/501/patient_pathological_data.json b/501/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..50b08534f396a60d8f49c3b56a3898025a25773f --- /dev/null +++ b/501/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "501", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/501/surgery_description.txt b/501/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c914370e82126f7d793767946b72e76f53274229 --- /dev/null +++ b/501/surgery_description.txt @@ -0,0 +1 @@ +Resektion, Neck diss. bds., Defektdeckung, Gestielter Lappen (Pectoralis-major) diff --git a/501/surgery_report.txt b/501/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..25f8a9cdc92871c354fe17ef8a34be6f592796cf --- /dev/null +++ b/501/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again: The exophytic tumor is visible, which extends from the beginning of the posterior wall of the hypopharynx over the lateral wall on the right to the arytenoid region and here in the arytenoid region also into the larynx. Tumor extends to the tip of the hypopharynx. Therefore, surgery with flap coverage is now indicated. Due to the patient's poor condition with renal insufficiency, liver insufficiency and portal vein hypertension as well as heart failure, a free flap is not indicated. Therefore, preoperative RCT is also not possible. The skin is now disinfected and all surgical areas are draped. An apron flap is then created in the typical manner and neck dissection is performed on both sides. Neck dissection on the right: A cranial lymph node conglomerate is visible, which grows towards the sternocleidomastoid muscle and is also connected to the accessorius nerve and reaches the vein. Conglomerate can be dissected from the vein. N. accessorius virtually runs through. Therefore, parts of the sternocleidomastoid muscle and the accessory nerve are included. Exposure of the omohyoid muscle caudally and finally the digastric muscle cranially. Vein can be visualized from caudal to cranial and the lymph node conglomerate can be dissected. Exposure of the internal and external carotid arteries and their branches. The vagus nerve can be visualized and preserved, as can the hypoglossal nerve. This results in a level II-V neck dissection and preservation of the branches of the cervical plexus. Subsequent left neck dissection: Dictation is still missing. Subsequent tumor resection. Skeletonization of the larynx. Detachment of the suprahyoid muscles from the hyoid bone. Dissection of the hyoid bone on both sides. Subsequent dissection of the thyroid gland including vascular supply by dissection caudally and laterally on both sides. The upper horn of the thyroid cartilage is isolated and the piriform sinus is pushed off on the left, this step is omitted on the right. The epiglottis is then exposed, taking the supraglottic fatty tissue with it, and the pharyngeal cavity is entered. Expose the tumor. Cut around the tumor by at least 1.5-2 cm on all sides. The wall falls to the base of the tongue and at least 70% of the posterior wall of the oropharynx. The left side is dissected with maximum protection of the piriform sinus. The specimen is removed including the larynx, partial preservation of the postcricoid mucosa initially. Separation of the larynx in a typical manner. Suture marking of the mucosal areas on the resected specimen. In addition, marginal sample from the caudal area of the pharyngeal wall to the postcricoid to the left side. Send for frozen section. In the frozen section, carcinoma in situ in all areas, also in the area of the marginal sample. Therefore, a circular resection 1.5 cm wide is performed again, with the sutures placed away from the tumor. Tumor remnants in the area of the base of the tongue and pharyngeal wall on the right in the frozen section. Therefore, another resection and subsequent marginal samples ...................................................... to the right, the pharyngeal side wall and from the entire posterior wall of the oropharynx including the base of the tongue. No more high-grade dysplasia here. Overall, however, field carcinomatization can be assumed despite the surgical R0 situation. The surgical site is now irrigated. Hemostasis. Overall dissection somewhat more difficult due to heavy bleeding during the entire operation as a result of portal hypertension. Overall, due to the patient's poor general condition, indication for a pedicled pectoralis major flap. There is gynecomastia. The flap is therefore drawn slightly more medially than usual. Size 12 x 10 cm. Marking. First lift off a bridge of the deltopectoral area. Then lift the pectoralis muscle and locate the artery. Then cut around the flap including the muscle and lift off the flap with the underlying muscle, whereby the shear sutures are also applied. Dissection of the flap on the pedicle up to the clavicle. Careful protection of the artery here. Then widen the tunnel again. Here again careful hemostasis. Pulling the flap through. Overall, the pectoralis flap is not particularly favorable, as the subcutaneous tissue is significantly thickened due to the gynecomastia. However, the flap can be successively sutured into the defect or to the residual mucosa, which is increasingly preserved at a thickness of 2 cm caudally upwards. A nasogastric tube for feeding was inserted beforehand. A PEG was not inserted because of the ascites. Now myotomy of the cricopharyngeal muscle on the left side, thereby relieving the pharyngo-oesophageal junction. Subsequent Provox prosthesis insertion. Insertion of a 12 mm prosthesis typically without complications due to the thickening of the tracheal wall. Flap suturing under tension due to the thick subcutaneous tissue and the poor malleability of the flap. The flap is then sutured to the left sternocleidomastoid muscle to relieve pressure and reduce the tendency towards retraction. The infrahyoid muscles are sutured caudally over the flap. Careful hemostasis is then performed. Suture back the apron flap and the epithelialization of the tracheostoma and insert a Redon drainage tube on both sides. Insertion of a size 8 tracheostomy tube. The wound in the thoracic area is closed in layers after mobilization of the skin with insertion of a total of 2 Redon drains. Completion of the procedure without complications. Patient transferred to the interdisciplinary surgical intensive care unit for monitoring. Low skin tension in the area of the stalk. Satisfactory skin perfusion on insertion of the flap. Please continue antibiotics, which were started preoperatively, with Unacid for one week. Increased risk of fistula due to the thickness of the subcutaneous tissue. Feeding via the inserted nasogastric tube for at least 10 to 12 days, then, depending on the course of the operation, gruel swallowing and diet build-up if necessary. Overall, cT3-4 hypopharyngeal carcinoma with clear field carcinomatization so that a laryngectomy with subtotal pharyngectomy was performed. Due to the risk factors, the defect was not covered with a microvascular pedicled flap. After receiving the histology, please present at the interdisciplinary tumor conference. Postoperative radiotherapy, possibly with Erbitux, is certainly still indicated. \ No newline at end of file diff --git a/502/InvasionFront_CD3_block21_x3_y5_patient502_0.json b/502/InvasionFront_CD3_block21_x3_y5_patient502_0.json new file mode 100644 index 0000000000000000000000000000000000000000..014bcaba1f9de193d5e83f399056c780ab9ae180 --- /dev/null +++ b/502/InvasionFront_CD3_block21_x3_y5_patient502_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 23037.8, + "Num Detections": 19419, + "Num Negative": 18088, + "Num Positive": 1331, + "Positive %": 6.854, + "Num Positive per mm^2": 576.12 + } +} \ No newline at end of file diff --git a/502/InvasionFront_CD3_block21_x4_y5_patient502_1.json b/502/InvasionFront_CD3_block21_x4_y5_patient502_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1b80a1523ad18add3d8f8f6bd04802ffbe845e48 --- /dev/null +++ b/502/InvasionFront_CD3_block21_x4_y5_patient502_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 23187.7, + "Num Detections": 18573, + "Num Negative": 18113, + "Num Positive": 460, + "Positive %": 2.477, + "Num Positive per mm^2": 208.65 + } +} \ No newline at end of file diff --git a/502/InvasionFront_CD8_block21_x3_y5_patient502_0.json b/502/InvasionFront_CD8_block21_x3_y5_patient502_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e2b8031eb357b0f6fbe94a5aa31607c12228d2d8 --- /dev/null +++ b/502/InvasionFront_CD8_block21_x3_y5_patient502_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 12318.5, + "Num Detections": 19650, + "Num Negative": 18481, + "Num Positive": 1169, + "Positive %": 5.949, + "Num Positive per mm^2": 512.38 + } +} \ No newline at end of file diff --git a/502/InvasionFront_CD8_block21_x4_y5_patient502_1.json b/502/InvasionFront_CD8_block21_x4_y5_patient502_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0163cda7ee6ce68664bdec976e5e1b7e47ff78e7 --- /dev/null +++ b/502/InvasionFront_CD8_block21_x4_y5_patient502_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 12318.5, + "Num Detections": 18833, + "Num Negative": 18362, + "Num Positive": 471, + "Positive %": 2.501, + "Num Positive per mm^2": 214.68 + } +} \ No newline at end of file diff --git a/502/TumorCenter_CD3_block21_x3_y5_patient502_0.json b/502/TumorCenter_CD3_block21_x3_y5_patient502_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ae9723c684a8ac03446e1c908914270934890328 --- /dev/null +++ b/502/TumorCenter_CD3_block21_x3_y5_patient502_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 15167.0, + "Num Detections": 19475, + "Num Negative": 18525, + "Num Positive": 950, + "Positive %": 4.878, + "Num Positive per mm^2": 399.42 + } +} \ No newline at end of file diff --git a/502/TumorCenter_CD3_block21_x4_y5_patient502_1.json b/502/TumorCenter_CD3_block21_x4_y5_patient502_1.json new file mode 100644 index 0000000000000000000000000000000000000000..52e046f5d49912d83e1ebe20437d2df12b402cb7 --- /dev/null +++ b/502/TumorCenter_CD3_block21_x4_y5_patient502_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 15142.0, + "Num Detections": 23254, + "Num Negative": 19689, + "Num Positive": 3565, + "Positive %": 15.33, + "Num Positive per mm^2": 1394.7 + } +} \ No newline at end of file diff --git a/502/TumorCenter_CD8_block21_x3_y5_patient502_0.json b/502/TumorCenter_CD8_block21_x3_y5_patient502_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1c959362aaa9295a9f3ba75ee6adebfed1fd39fe --- /dev/null +++ b/502/TumorCenter_CD8_block21_x3_y5_patient502_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 27385.5, + "Num Detections": 20057, + "Num Negative": 17601, + "Num Positive": 2456, + "Positive %": 12.25, + "Num Positive per mm^2": 1030.6 + } +} \ No newline at end of file diff --git a/502/TumorCenter_CD8_block21_x4_y5_patient502_1.json b/502/TumorCenter_CD8_block21_x4_y5_patient502_1.json new file mode 100644 index 0000000000000000000000000000000000000000..36b01085bef657dea2882375b1fa4e72e09c5352 --- /dev/null +++ b/502/TumorCenter_CD8_block21_x4_y5_patient502_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 27485.4, + "Num Detections": 22348, + "Num Negative": 15629, + "Num Positive": 6719, + "Positive %": 30.07, + "Num Positive per mm^2": 2646.5 + } +} \ No newline at end of file diff --git a/502/history_text.txt b/502/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..447625db12854d8886f6cc6b660254395f985ede --- /dev/null +++ b/502/history_text.txt @@ -0,0 +1 @@ +Following an external biopsy, the patient was found to have a carcinoma in situ on the left side and a smooth mucosal protrusion on the right side in the area of the anterior vocal fold on the right side. There is therefore an indication for further clarification and, if necessary, tumor removal. \ No newline at end of file diff --git a/502/icd_codes.txt b/502/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3fc441e4d4825c4aa1cb2d74ab85b413db0db51b --- /dev/null +++ b/502/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 ] \ No newline at end of file diff --git a/502/ops_codes.txt b/502/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b5f151876252cb371dbda9e056ee8df96bd4bb7a --- /dev/null +++ b/502/ops_codes.txt @@ -0,0 +1 @@ +Chordektomie durch Thyreotomie[5-302.2 ] Biopsie der Glottis durch Inzision[1-549.1 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische indirekte Pharyngoskopie[1-611.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/502/patient_clinical_data.json b/502/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..697a1f549142e2525396e3e27a82a30840c3659f --- /dev/null +++ b/502/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 63, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/502/patient_pathological_data.json b/502/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..87c00b69b6917e8911f91b5089c50ec8aeaf4e53 --- /dev/null +++ b/502/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "502", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/502/surgery_description.txt b/502/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8327c6149aa318f600c76bec9f038a1a7a0246b1 --- /dev/null +++ b/502/surgery_description.txt @@ -0,0 +1 @@ +Kehlkopfteilresektion v. außen diff --git a/502/surgery_report.txt b/502/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..151663fdba5a287d844cf83dbfcd297c298e0d6c --- /dev/null +++ b/502/surgery_report.txt @@ -0,0 +1 @@ +After an introductory consultation with the anesthesiology colleagues, the glottic plane is first adjusted by laryngoscopy. Then, using 0 degree optics, visualization up to the glottic plane. This reveals an uneven mucosal change on the left side and a smooth mucosal protrusion on the right anterior side. The subglottic slope and the trachea are completely free of irritation and unremarkable. The patient is then intubated somewhat laboriously by the surgeon. The patient is then repositioned for esophagoscopy. The mucosa is found to be free of irritation when the flexible instrument is inserted into the esophagus. The patient is then viewed through to the stomach, where a regular mucosal relief can also be seen. After aspiration of the insufflated air, careful inspection of the esophagus during reflection. Here too, the mucosal conditions are normal. The patient is then repositioned for inspection of the oral cavity and oropharynx. Here too, the conditions are normal and unremarkable. Remove the Kleinsasser tube. Then, the hypopharynx is examined, where the mucosal conditions are also normal and without irritation. Then add the support autoscopy and the surgical microscope. Difficult adjustment of the glottic plane. The findings described above can be seen here. A deep sample is now taken from the area of the anterior third of the vocal fold on the right side under intact mucosa, which is carefully split with scissors. This is sent for frozen section diagnostics. After the diagnosis of an invasive carcinoma is made, the intraoperative endoscopic site is inspected again. This shows that the tumor is moving far forward into the anterior commissure. With difficult positioning of the patient, reliable tumor control from the endolaryngeal side is not possible. The decision is therefore made to operate on the larynx from the outside. After removing all instruments, the patient is repositioned for partial laryngeal resection from the outside. Injection of local anesthetic with adrenaline. Then Z-shaped incision prelaryngeal. Layered preparation in depth. Separation of the prelaryngeal muscles. The muscles are then pushed away from the anterior surface of the larynx. Slitting of the perichondrium. Then opening of the thyroid cartilage with the wheel. Horizontal opening of the ligamentum conicum and opening of the larynx. This shows that the tumor is significantly larger than initially expected from the endolaryngeal side. The tumor is then detached from the inner surface of the thyroid cartilage together with the perichondrium. Further dissection in the dorsal direction. The tumor almost reaches the vocal process. The tumor is deposited here near the vocal process. ................................ Parts of the subglottic slope are also resected. The resection extends cranially into the entrance of the pyriform sinus. The pouch ligament is unaffected by the tumor and remains completely intact. In the area of the anterior commissure, however, the tumor slightly crosses the midline, so that the resection must also extend to the opposite side here. Then take frozen section samples from all marginal areas of the resection. These are sent for frozen section diagnostics. However, it should be noted that the cranial and dorsal margins of the right side as well as the lower center are not in sano. Therefore, another clear resection in the area of the upper dorsal margin. The pocket ligament remains intact. Resection of the entire ligamentum conicum, the entire horizontal on the cricoid cartilage and at the attachment to the thyroid cartilage. These resected areas are sent for final histological diagnosis. Then marginal samples are taken again for rapid diagnosis from the area of the caudal margin of the thyroid cartilage on the outside and endolaryngeally at the transition to the trachea. These are still found to be tumor-free intraoperatively. The edge specimen of the dorsal cranial margin was also found to be tumor-free in the frozen section, so that an R0 resection can now be assumed. Careful hemostasis is therefore performed. Subsequently, a burr hole is made in the area of the thyroid cartilage and the ligament is tightened anteriorly in order to possibly ensure better voice regulation. In addition, two further drill holes are made in the area of the thyroid cartilage at the top and bottom on both sides. A laryngeal wedge is then sutured into place using these drill holes. The prelaryngeal muscles are then mobilized and sutured in front of the larynx. A slightly gaping space remains due to the missing ligamentum conicum between the cricoid cartilage and thyroid cartilage. This is also closed prelaryngeally with mobilized muscles. A large wound flap is inserted here, which is then drained to the outside. A second layer of prelaryngeal muscle is sutured again. Subcutaneous suture and skin suture and application of a pressure bandage. Before closing the larynx, a marginal sample was taken from the pocket ligament on the left side. If a carcinoma in situ is also found here, these findings should be discussed in detail in the tumor conference with regard to adjuvant therapy. A follow-up MLE should be planned for the patient in 6 weeks. If necessary, Keel removal can then also be performed. Final consultation with the anesthesia colleagues. \ No newline at end of file diff --git a/503/InvasionFront_CD3_block3_x3_y6_patient503_0.json b/503/InvasionFront_CD3_block3_x3_y6_patient503_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4c82acaa339d04c7039a2bac4af9f7be0deab0b4 --- /dev/null +++ b/503/InvasionFront_CD3_block3_x3_y6_patient503_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12968.1, + "Centroid Y µm": 20464.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/503/InvasionFront_CD3_block3_x4_y6_patient503_1.json b/503/InvasionFront_CD3_block3_x4_y6_patient503_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9ffa03c88ee90eeb43a38b95578b261dc7816e36 --- /dev/null +++ b/503/InvasionFront_CD3_block3_x4_y6_patient503_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15341.9, + "Centroid Y µm": 20714.0, + "Num Detections": 20805, + "Num Negative": 18700, + "Num Positive": 2105, + "Positive %": 10.12, + "Num Positive per mm^2": 941.48 + } +} \ No newline at end of file diff --git a/503/InvasionFront_CD8_block3_x3_y6_patient503_0.json b/503/InvasionFront_CD8_block3_x3_y6_patient503_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a66625ed19fec3243c9cce961cd5637f19fcc382 --- /dev/null +++ b/503/InvasionFront_CD8_block3_x3_y6_patient503_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12568.3, + "Centroid Y µm": 14692.2, + "Num Detections": 14054, + "Num Negative": 13333, + "Num Positive": 721, + "Positive %": 5.13, + "Num Positive per mm^2": 376.6 + } +} \ No newline at end of file diff --git a/503/InvasionFront_CD8_block3_x4_y6_patient503_1.json b/503/InvasionFront_CD8_block3_x4_y6_patient503_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7bcb4577515ae4576fdfe2c967450af76615b986 --- /dev/null +++ b/503/InvasionFront_CD8_block3_x4_y6_patient503_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15067.0, + "Centroid Y µm": 14717.2, + "Num Detections": 19823, + "Num Negative": 18893, + "Num Positive": 930, + "Positive %": 4.692, + "Num Positive per mm^2": 429.59 + } +} \ No newline at end of file diff --git a/503/TumorCenter_CD3_block3_x3_y6_patient503_0.json b/503/TumorCenter_CD3_block3_x3_y6_patient503_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fff883a9823e84b953c79697b0d86f9f2fd0b2d7 --- /dev/null +++ b/503/TumorCenter_CD3_block3_x3_y6_patient503_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11007.7, + "Centroid Y µm": 21189.8, + "Num Detections": 10332, + "Num Negative": 8597, + "Num Positive": 1735, + "Positive %": 16.79, + "Num Positive per mm^2": 1429.5 + } +} \ No newline at end of file diff --git a/503/TumorCenter_CD3_block3_x4_y6_patient503_1.json b/503/TumorCenter_CD3_block3_x4_y6_patient503_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a8184b3e898e8c774d296edc831e01ae24635a63 --- /dev/null +++ b/503/TumorCenter_CD3_block3_x4_y6_patient503_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13482.9, + "Centroid Y µm": 21320.8, + "Num Detections": 16345, + "Num Negative": 14064, + "Num Positive": 2281, + "Positive %": 13.96, + "Num Positive per mm^2": 1284.2 + } +} \ No newline at end of file diff --git a/503/TumorCenter_CD8_block3_x3_y6_patient503_0.json b/503/TumorCenter_CD8_block3_x3_y6_patient503_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f791d9e7d14a38464ed659b16759ad991838dd1a --- /dev/null +++ b/503/TumorCenter_CD8_block3_x3_y6_patient503_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11818.7, + "Centroid Y µm": 16316.4, + "Num Detections": 20816, + "Num Negative": 19405, + "Num Positive": 1411, + "Positive %": 6.778, + "Num Positive per mm^2": 615.71 + } +} \ No newline at end of file diff --git a/503/TumorCenter_CD8_block3_x4_y6_patient503_1.json b/503/TumorCenter_CD8_block3_x4_y6_patient503_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e4c7ac7eb4d5846d0946a242f3635a84c4d6c064 --- /dev/null +++ b/503/TumorCenter_CD8_block3_x4_y6_patient503_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14267.4, + "Centroid Y µm": 16616.2, + "Num Detections": 15398, + "Num Negative": 14957, + "Num Positive": 441, + "Positive %": 2.864, + "Num Positive per mm^2": 272.38 + } +} \ No newline at end of file diff --git a/503/history_text.txt b/503/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..bb38a536626d51e11a3e092e4f10ee198785bdae --- /dev/null +++ b/503/history_text.txt @@ -0,0 +1 @@ +Patient with a left cervical regional II/III mass that had been present since <2015> and had progressed in size despite conservative treatment. In the preoperative PET-CT, there was a high-susceptibility mass in the left tonsil. Thus indication for the above measures. \ No newline at end of file diff --git a/503/icd_codes.txt b/503/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..08f009ae4ceef2847cee3dfe7bbf07b52814bba8 --- /dev/null +++ b/503/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Tonsillen[C09.9 L] Halslymphknotenmetastasen[C77.0 L] \ No newline at end of file diff --git a/503/ops_codes.txt b/503/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1bb245116815b0bdfcfd6091a736fb74916658e6 --- /dev/null +++ b/503/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie [ohne Adenotomie] radikal transoral[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] \ No newline at end of file diff --git a/503/patient_clinical_data.json b/503/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..06a5d3dacabca574b30afcefa0502a18c3943bb9 --- /dev/null +++ b/503/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 49, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 3, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/503/patient_pathological_data.json b/503/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..18804b0b94366375fbbc8efb2a5dfef9e1effcce --- /dev/null +++ b/503/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "503", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/503/surgery_description.txt b/503/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d6f16d40e102ae58f530ae135001584bd7beabdf --- /dev/null +++ b/503/surgery_description.txt @@ -0,0 +1 @@ +Tonsillektomie, Neck dissection diff --git a/503/surgery_report.txt b/503/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..559fa0feb9fb9cb4c3e839038d47a754708f664c --- /dev/null +++ b/503/surgery_report.txt @@ -0,0 +1 @@ +Initially induction of anesthesia and transoral endotracheal intubation by the anesthesia colleagues and positioning of the patient by the surgeon. Placement of the Mc Ivor spatula in the oral cavity and inspection. This revealed a slightly enlarged, otherwise unremarkable tonsil on the left side. Parauvular incision. Exposure of the tonsil capsule. Treatment of the upper pole using bipolar coagulation. Preparation from cranial to caudal, non-irritating conditions, good preparation conditions. The lower pole of the left tonsil can be removed without difficulty. The specimen is sent for intraoperative frozen section examination, which is assessed by the pathology colleagues and results in the diagnosis of HBV-positive squamous cell carcinoma of the left tonsil. The decision was made to perform a modified radical neck dissection on the left side. Application of local anesthesia cervically on the left, skin ablation and sterile draping. Creation of a modified, curved skin incision. Dissection of the subcutaneous tissue of the platysma and exposure of the auricular nerve and protection of the same. Exposure of the accessorius nerve in depth, the omohyoid muscle, the digaster muscle (venter posterior) and the capsule of the submandibular gland. First, the mass is bypassed in the sense of a capsular dissection and removed without difficulty. Then dissect along the cervical vascular sheath from caudal to cranial and expose the internal jugular vein of the vagus nerve and the common carotid artery. Exposure and sparing of the plexus branches, successive evacuation of regions Ib, IIa, IIb, III, IV and Va while sparing the above-mentioned structures. Removal of the anterior neck specimen. Hemostasis by means of bipolar coagulation. Dry conditions. Irrigation of the wound using hydrogen peroxide and Ringer's solution. Placement of a 10-gauge Redon drain. Two-layer wound closure. Application of a pressure dressing. Completion of the procedure without complications. In case of unclear findings regarding the margin situation during the intraoperative frozen section examination and otherwise almost R0 situation in all margins. Decision to take 3 margin samples (cranial, lateral, caudal), which are sent for final histology. Repeated inspection. Dry conditions, removal of the Mc Ivor spatula. Placement of a nasogastric feeding tube in the typical manner. Completion of the procedure without complications. Please feed for 7 days via the inserted nasogastric feeding tube. After that, careful diet build-up. Suture removal on the 8th postoperative day and prompt presentation at our interdisciplinary tumor conference to plan further therapy. \ No newline at end of file diff --git a/504/InvasionFront_CD3_block3_x1_y4_patient504_0.json b/504/InvasionFront_CD3_block3_x1_y4_patient504_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5f7d070d89d99a1a941c5b89e76c7e16a596a3a3 --- /dev/null +++ b/504/InvasionFront_CD3_block3_x1_y4_patient504_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5647.0, + "Centroid Y µm": 14042.6, + "Num Detections": 21440, + "Num Negative": 20970, + "Num Positive": 470, + "Positive %": 2.192, + "Num Positive per mm^2": 183.26 + } +} \ No newline at end of file diff --git a/504/InvasionFront_CD3_block3_x2_y4_patient504_1.json b/504/InvasionFront_CD3_block3_x2_y4_patient504_1.json new file mode 100644 index 0000000000000000000000000000000000000000..de8d69ee109a84ade6e10d8450bd9c056b89c9ec --- /dev/null +++ b/504/InvasionFront_CD3_block3_x2_y4_patient504_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8420.5, + "Centroid Y µm": 14392.4, + "Num Detections": 17900, + "Num Negative": 17645, + "Num Positive": 255, + "Positive %": 1.425, + "Num Positive per mm^2": 120.04 + } +} \ No newline at end of file diff --git a/504/InvasionFront_CD8_block3_x1_y4_patient504_0.json b/504/InvasionFront_CD8_block3_x1_y4_patient504_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b84bc981226e2ed69fa69accba06140275f61b5 --- /dev/null +++ b/504/InvasionFront_CD8_block3_x1_y4_patient504_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5096.4, + "Centroid Y µm": 9909.2, + "Num Detections": 17229, + "Num Negative": 17067, + "Num Positive": 162, + "Positive %": 0.9403, + "Num Positive per mm^2": 65.58 + } +} \ No newline at end of file diff --git a/504/InvasionFront_CD8_block3_x2_y4_patient504_1.json b/504/InvasionFront_CD8_block3_x2_y4_patient504_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0b4137c2b38d57aeef15e88924c7c827c5592482 --- /dev/null +++ b/504/InvasionFront_CD8_block3_x2_y4_patient504_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7751.0, + "Centroid Y µm": 9833.8, + "Num Detections": 16416, + "Num Negative": 16344, + "Num Positive": 72, + "Positive %": 0.4386, + "Num Positive per mm^2": 31.63 + } +} \ No newline at end of file diff --git a/504/TumorCenter_CD3_block3_x1_y4_patient504_0.json b/504/TumorCenter_CD3_block3_x1_y4_patient504_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bfa064ffbd63eac9205ac822a6ac0c621079bd33 --- /dev/null +++ b/504/TumorCenter_CD3_block3_x1_y4_patient504_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3823.0, + "Centroid Y µm": 16116.5, + "Num Detections": 22614, + "Num Negative": 20554, + "Num Positive": 2060, + "Positive %": 9.109, + "Num Positive per mm^2": 750.42 + } +} \ No newline at end of file diff --git a/504/TumorCenter_CD3_block3_x2_y4_patient504_1.json b/504/TumorCenter_CD3_block3_x2_y4_patient504_1.json new file mode 100644 index 0000000000000000000000000000000000000000..60ba6b20dc8b9e29d66eb33c14f7e35ae256a54b --- /dev/null +++ b/504/TumorCenter_CD3_block3_x2_y4_patient504_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6171.7, + "Centroid Y µm": 16141.5, + "Num Detections": 25560, + "Num Negative": 24794, + "Num Positive": 766, + "Positive %": 2.997, + "Num Positive per mm^2": 263.01 + } +} \ No newline at end of file diff --git a/504/TumorCenter_CD8_block3_x1_y4_patient504_0.json b/504/TumorCenter_CD8_block3_x1_y4_patient504_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1b751aa6ad48a77321cfa7c2a3973a6000db398e --- /dev/null +++ b/504/TumorCenter_CD8_block3_x1_y4_patient504_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4847.4, + "Centroid Y µm": 10994.2, + "Num Detections": 23514, + "Num Negative": 23042, + "Num Positive": 472, + "Positive %": 2.007, + "Num Positive per mm^2": 175.08 + } +} \ No newline at end of file diff --git a/504/TumorCenter_CD8_block3_x2_y4_patient504_1.json b/504/TumorCenter_CD8_block3_x2_y4_patient504_1.json new file mode 100644 index 0000000000000000000000000000000000000000..db5d98abe43736acdf71ec1fff14114137674493 --- /dev/null +++ b/504/TumorCenter_CD8_block3_x2_y4_patient504_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7271.2, + "Centroid Y µm": 11244.0, + "Num Detections": 23011, + "Num Negative": 22897, + "Num Positive": 114, + "Positive %": 0.4954, + "Num Positive per mm^2": 44.26 + } +} \ No newline at end of file diff --git a/504/history_text.txt b/504/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..68c0d33f1c8d982defff2ad9c14a1f80efe83bc7 --- /dev/null +++ b/504/history_text.txt @@ -0,0 +1 @@ +Patient with post-operative resection of an oropharyngeal carcinoma using robot-assisted surgery including neck dissection on the right. Now recurrence clinically and according to imaging cT3 to 4. In CT the tumor grows up to the vicinity of the hyoid bone. Therefore, the above-mentioned surgery is now indicated. \ No newline at end of file diff --git a/504/icd_codes.txt b/504/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..22d10572fc7d8a5e7a15c33b5b31b6bfc7923dde --- /dev/null +++ b/504/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/504/ops_codes.txt b/504/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..148602eeec895aa6b664fb8c5091d71331ef07b6 --- /dev/null +++ b/504/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.14 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Wechsel eines vaskulären Implantates[5-394.3 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Spalthaut großflächig Empfängerstelle Hand[5-902.49 L] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/504/patient_clinical_data.json b/504/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4564f5245f1f788f69ef1c91405d9baa7bbb4639 --- /dev/null +++ b/504/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/504/patient_pathological_data.json b/504/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b44ec2b7b2902a0b5f6c8b8034293904a72b4cc9 --- /dev/null +++ b/504/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "504", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/504/surgery_description.txt b/504/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1f71239ffefd0351bc690bef300c28357e16e508 --- /dev/null +++ b/504/surgery_description.txt @@ -0,0 +1 @@ +Resektion (TORS), Neck diss., diff --git a/504/surgery_report.txt b/504/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c656c395695ac173d20a2f2e8ac9e9137250b59d --- /dev/null +++ b/504/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again: The exophytic tumor is visible, which grows from the lower tonsil pole via the glossoalveolar or glossotonsillar region to the base of the tongue, via the lateral wall of the oropharynx to the posterior wall of the oropharynx. Therefore, surgical indication for resection with flap coverage. First, skin disinfection and sterile draping of all surgical areas, including the right forearm and thigh. First tracheostoma placement and PEG placement by . After problem-free orotracheal intubation by the anesthesia colleagues, first tracheostomy in the typical manner: Marking of the landmarks and the well palpable cricoid cartilage level and prior local anesthetic infiltration with Ultracaine 2% with suprarenin addition caudal to the cricoid cartilage. Skin incision according to Kocher and separation of the skin and subcutaneous tissue. Dissection in layers and then exposure of the infrahyoid musculature. Ligation of a small median vein beforehand. Dissection on the cricoid cartilage and from here dissection caudally on the trachea without significant thyroid tissue, thus now a good view of the anterior surface of the trachea after previous transection of the linea alba. Then opening of the trachea between the 2nd and 3rd cartilage clasp and insertion of a visor tracheotomy and circular tension-free mucocutaneous anastomosis. Problem-free intubation onto an LE tube. Now PEG insertion: Pre-mirroring with the flexible endoscope while inspecting the irritation-free esophageal mucosa and air insufflation in the stomach. If diaphanoscopy is excellent, insertion of the PEG using the thread pull-through method in the typical manner. Perioperative administration of 3 g Unacid. On withdrawal of the endoscope, re-inspection of the lesion-free esophageal mucosa. Subsequent repositioning for neck dissection and tumor resection by : Opening of the old scar and extension slightly submentally. Extension also caudally. Subsequent neck dissection on the right: exposure of the digastric muscle, omohyoid muscle, sternocleidomastoid muscle. Exposure of the internal carotid artery, external carotid artery, superior thyroid artery, facial artery and lingual artery. Exposure of the hypoglossal nerve, vagus nerve and accessorius nerve. Clearing of levels II to V, preserving the branches of the cervical plexus. Subsequent removal of the right submandibular gland in preparation for tumor resection. Also removal of level I b lymph nodes. The entire dissection was considerably more difficult due to scarring, in particular the veins and also the larger vessels were distorted cranially superior to the pharyngeal wall in the sense of severe scarring. Difficult removal of the scars. A facial vein with 2 outlets and a further outlet from the internal jugular vein can be dissected from the scar tissue. Subsequently, combined transoral, transcervical tumor resection: All large vessels and nerves are ligated using Wessel loops and pulled to the side. The tumor is then resected under internal and external control. Incision of the macroscopically visible tumor at a distance of 1.5 cm on all sides. The area of the posterior palatal arch, the entire tonsil lobe, the mucosa up to the alveolar ridge, parts of the base of the tongue, the lateral wall of the oropharynx and approx. 2 thirds of the posterior wall of the oropharynx are resected. Resection up to the border of the nasopharynx. The specimen is sent to the frozen section marked with a thread. Also marginal samples from basal, which includes hyoid bone and adjacent soft tissue. Marginal specimen from the vallecula to the caudal base of the tongue and marginal specimen from the posterior palatal arch to the upper posterior wall of the oropharynx adjacent to the nasopharynx. Marginal samples are thread-marked for frozen section. The frozen section still shows infiltrates in the area of the cranial margin of the posterior palatal arch and the cranial oropharyngeal wall. Here, another resection over several millimeters and another removal of a marginal sample, which extends from the border area at the alveolar ridge over the posterior palatal arch remnant to the posterior oropharyngeal wall. This is again sent to the frozen section. Carcinoma in situ infiltrates in the medial cranial area, i.e. in the oropharyngeal area extending to the nasopharynx. Therefore, another resection and subsequent removal of a marginal sample from the cranial oropharyngeal area or now already the nasopharyngeal mucosa area. No more higher-grade dysplasia or carcinoma infiltrates here. Thus a surgical R0 situation, although field carcinomatization cannot be completely ruled out. Typical skin incision and neck dissection on the left: This is performed in the same way as on the right side. Evacuation of levels II to V and preservation of the structures and branches of the cervical plexus. Ligation in the area of the inferior lymphatic vessels. Subsequent careful irrigation and hemostasis of all surgical areas. Measurement of the defect and the three-dimensional configuration. Defect length approx. 11 cm and width 8 to 9 cm. Recording on the forearm according to the orientation. Subsequent elevation of the forearm flap: First, recutting of the ulnar and superfascial preparation. Then extend cranially to the crook of the elbow. Exposure of the superficial venous system and the connection to the deep venous system. Subsequent radial incision. Exposure and preservation of the lateral antebrachial cutaneous nerve. As far as possible. Caudal exposure of the radial artery. After clamping and sufficient time with adequate saturation of the forearm, cut through. The artery is ligated with 4-0 Prolene stitches. Lift the flap along its deep pedicle, including the superficial pedicle. Outgoing vessels are clipped or bipolar coagulated. Two branches of the cephalic vein and a confluence can be visualized in the antecubital fossa. The interosseous artery is cut and clipped after clamping and good saturation. The cephalic vein, the confluence and the radial artery are then removed. The artery is closed with stitching sutures after removal. The veins are ligated. Irrigation of the flap. The flap is then inserted into the defect. Successive suturing using 3-0 Vicryl single button sutures. Tension-free closure is achieved, even with reconstruction of the posterior palatal arch. Difficult suturing cranially in the area of the nasopharynx. Subsequent vascular anastomoses. Conditioning of the radial artery and the superior thyroid artery. The superior thyroid artery must be incised slightly, followed by anastomosis with 8-0 Ethilon single-button sutures. After opening the clamp, good arterial flow, good venous return. One of the cephalic veins is anastomosed with an outlet from the prepared facial vein after appropriate conditioning with a 3-0 coupler. Here, too, good venous return after opening the clamps, positive smear phenomenon. The other outlet from the facial vein is anastomosed with the 2nd outlet of the cephalic vein. Here, too, the smear phenomenon is positive after opening the clamps, good venous flow after opening the clamps. The confluence is clipped. Subsequent preparation and fixation of the pedicle in a favorable position. Irrigation of the surgical site. Hemostasis. Wound closure in layers on the right and insertion of 2 flaps on the left with insertion of a Redon drain. Epithelialization of the tracheostoma is completed. Insertion of an 8 mm tracheostomy tube, which is fixed with sutures. Thoracic inspection shows flap well perfused. The forearm is primarily closed cranially, the defect is closed caudally using split skin taken laterally from the right thigh with a thickness of 0.8 mm. Here, after taking swabs and relief incisions, Mepilex is taken and loose compresses are applied and fixed with absorbent cotton. A Kramer splint is then fitted and secured with an elastic bandage. Positioning of the arm. Saturation of the hand is always above 95 to 100 %. Starch is applied to the thigh area and then Mepilex. The procedure is completed without complications. Patient goes to the intensive care unit ventilated. Please continue antibiotics, which were started intraoperatively with Unacid, for approx. 1 week. Feeding via the inserted PEG tube, which should be loosened after 24 hours, for approx. 10 days, followed by gruel swallowing and, if necessary, diet build-up. Check blood flow to the flap clinically or by Doppler. Overall cT4a oropharyngeal carcinoma recurrence. Please wait for lymph node status and then presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/505/InvasionFront_CD3_block21_x5_y5_patient505_0.json b/505/InvasionFront_CD3_block21_x5_y5_patient505_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aaf797abad1ebaf9b3fe1e31a2b828c62bbef901 --- /dev/null +++ b/505/InvasionFront_CD3_block21_x5_y5_patient505_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 23312.7, + "Num Detections": 17738, + "Num Negative": 17248, + "Num Positive": 490, + "Positive %": 2.762, + "Num Positive per mm^2": 245.12 + } +} \ No newline at end of file diff --git a/505/InvasionFront_CD3_block21_x6_y5_patient505_1.json b/505/InvasionFront_CD3_block21_x6_y5_patient505_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd0e9ffde713184df9e1578c64c271eeb02794fb --- /dev/null +++ b/505/InvasionFront_CD3_block21_x6_y5_patient505_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21413.7, + "Centroid Y µm": 23362.6, + "Num Detections": 7321, + "Num Negative": 7015, + "Num Positive": 306, + "Positive %": 4.18, + "Num Positive per mm^2": 357.87 + } +} \ No newline at end of file diff --git a/505/InvasionFront_CD8_block21_x5_y5_patient505_0.json b/505/InvasionFront_CD8_block21_x5_y5_patient505_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7d623ecf2aa68fdc5836128db689641c4fe937b8 --- /dev/null +++ b/505/InvasionFront_CD8_block21_x5_y5_patient505_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 12318.5, + "Num Detections": 16284, + "Num Negative": 15820, + "Num Positive": 464, + "Positive %": 2.849, + "Num Positive per mm^2": 254.63 + } +} \ No newline at end of file diff --git a/505/InvasionFront_CD8_block21_x6_y5_patient505_1.json b/505/InvasionFront_CD8_block21_x6_y5_patient505_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9bd87a4c163d008060b9b9372649e68a618f50f8 --- /dev/null +++ b/505/InvasionFront_CD8_block21_x6_y5_patient505_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 12168.6, + "Num Detections": 16244, + "Num Negative": 15935, + "Num Positive": 309, + "Positive %": 1.902, + "Num Positive per mm^2": 170.52 + } +} \ No newline at end of file diff --git a/505/TumorCenter_CD3_block21_x5_y5_patient505_0.json b/505/TumorCenter_CD3_block21_x5_y5_patient505_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0bf5d3b123556b642df60f8aca9b3cbfc6e98948 --- /dev/null +++ b/505/TumorCenter_CD3_block21_x5_y5_patient505_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 15092.0, + "Num Detections": 19503, + "Num Negative": 17691, + "Num Positive": 1812, + "Positive %": 9.291, + "Num Positive per mm^2": 898.51 + } +} \ No newline at end of file diff --git a/505/TumorCenter_CD3_block21_x6_y5_patient505_1.json b/505/TumorCenter_CD3_block21_x6_y5_patient505_1.json new file mode 100644 index 0000000000000000000000000000000000000000..abd0b2cdf503585e7ad5d02fa6952a301e9b0b69 --- /dev/null +++ b/505/TumorCenter_CD3_block21_x6_y5_patient505_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 15067.0, + "Num Detections": 16708, + "Num Negative": 16223, + "Num Positive": 485, + "Positive %": 2.903, + "Num Positive per mm^2": 245.84 + } +} \ No newline at end of file diff --git a/505/TumorCenter_CD8_block21_x5_y5_patient505_0.json b/505/TumorCenter_CD8_block21_x5_y5_patient505_0.json new file mode 100644 index 0000000000000000000000000000000000000000..65b80f7a94079d6c716438fd114d8166670f952c --- /dev/null +++ b/505/TumorCenter_CD8_block21_x5_y5_patient505_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 27560.4, + "Num Detections": 18284, + "Num Negative": 15209, + "Num Positive": 3075, + "Positive %": 16.82, + "Num Positive per mm^2": 1585.6 + } +} \ No newline at end of file diff --git a/505/TumorCenter_CD8_block21_x6_y5_patient505_1.json b/505/TumorCenter_CD8_block21_x6_y5_patient505_1.json new file mode 100644 index 0000000000000000000000000000000000000000..41782e3001142d2ff18ee7db8134f1b024311de0 --- /dev/null +++ b/505/TumorCenter_CD8_block21_x6_y5_patient505_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21238.8, + "Centroid Y µm": 27660.4, + "Num Detections": 16744, + "Num Negative": 15186, + "Num Positive": 1558, + "Positive %": 9.305, + "Num Positive per mm^2": 808.76 + } +} \ No newline at end of file diff --git a/505/history_text.txt b/505/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..28ce31f3258565fa65f95e2b941433a42e6c8435 --- /dev/null +++ b/505/history_text.txt @@ -0,0 +1 @@ +The patient had a post-operative panendoscopy and was diagnosed with cT4a cN2c laryngeal carcinoma with only slight postcricoid spread. Postoperatively, the patient developed acute dyspnea, which is why he was initially tracheotomized and then revised again due to acute bleeding. This is why the above-mentioned operation is now indicated. \ No newline at end of file diff --git a/505/icd_codes.txt b/505/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..384a499466a891cfe9bc00718b460117487ae6cd --- /dev/null +++ b/505/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] Bösartige Neubildung der Regio postcricoidea[C13.0 ] \ No newline at end of file diff --git a/505/ops_codes.txt b/505/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..461755b6f6cc9bb13fc81970cd4fc3d109b12759 --- /dev/null +++ b/505/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Destruktion: Elektrokoagulation[5-300.30 ] Laryngektomie: Mit Pharyngektomie: Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Permanente Tracheostomie: Tracheotomie[5-312.0 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 B] \ No newline at end of file diff --git a/505/patient_clinical_data.json b/505/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..005ca86a2080393c65f179d044cb74c71c3c8f6f --- /dev/null +++ b/505/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/505/patient_pathological_data.json b/505/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ee832808ab408b9def8dbf643b4f0b022ed88db1 --- /dev/null +++ b/505/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "505", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/505/surgery_description.txt b/505/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3c22751695b6034e9f1b16ff0e140a32e987b00f --- /dev/null +++ b/505/surgery_description.txt @@ -0,0 +1 @@ +Komplette Laryngektomie, Neck dissection Level Ib - V, PEG-Anlage, Provox diff --git a/505/surgery_report.txt b/505/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3141deb8de0321caf9c29c6d949d6cefb6d17d9c --- /dev/null +++ b/505/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation via the tracheostoma, pharyngoscopy and throat inspection are performed again. This reveals a very dehiscent and inflamed tracheostoma. The pharyngoscopy/laryngoscopy reveals a tumor that completely occupies the endolarynx, but also has a clear, partially submucosal component that has already reached the mucosa in the area of the postcricoid and also in the area of the median wall of the right piriform sinus and slightly also of the left piriform sinus. The PEG system is now placed first, so flexible esophagogastroscopy is performed, followed by diaphanoscopy and placement of the PEG tube in the typical manner using the suture retraction method. Now proceed to the laryngectomy: an apron flap is formed for this, which goes into the old tracheostoma, where the severely inflamed skin is now partially resected. Now form the apron flap subplatysmal. Then turn to the neck dissection of the right side: Here several, clearly enlarged lymph nodes are visible, which are partially cemented together with the jugularis. The sternocleidomastoid muscle, the omohyoid muscle and the digastric muscle are thus exposed, then the accessor nerve is exposed and spared. The next step is to dissect along the internal jugular vein from caudal to cranial. Here, resection of the metastases directly cranial to the omohyoid muscle is quite difficult because the latter are connected to the jugular vein. The resection is ultimately successful. After complete exposure of the internal jugular vein, the lateral neck preparation is formed while sparing the vagus nerve, carotid artery, accessorius nerve and plexus branches. Several enlarged lymph nodes are also found here. Now follow the digaster anteriorly. Expose the submandibular gland. Tracing of the omohyoid gland and formation of the medial neck preparation while sparing the hypoglossal nerve and facial vein; the superior thyroid artery is also exposed and spared. Now proceed to the neck dissection on the left side: identical procedure here with only slightly enlarged lymph nodes. Expose the digastric, omohyoid and sternocleidomastoid muscles. Sparing of the accessorius nerve and formation of the internal jugular vein from caudal to cranial. Then dissect the lateral neck preparation while sparing the accessorius nerve and the plexus branches. Now turn to the medial neck preparation. Expose the facial vein and the hypoglossal nerve, which are spared, and follow the digastric muscle anteriorly. Expose and spare the submandibular gland. Then remove the medial neck preparation. Now the laryngectomy is performed: First separate the 2 halves of the thyroid gland from the trachea and then remove the omohyoid muscle and the cervical vascular sheath from the swallowing duct. The superior laryngeal nerve and its bundle are severed and ligated on both sides. The hyoid bone is now skeletonized in the cranial region and then the inferior pharyngeal constrictor muscle is detached from the lateral thyroid cartilage and dissected on the left side of the piriform sinus. Detachment of the latter from the inside of the larynx. On the right side, this step is omitted if a tumor is present. Now prepare the cranial side of the hyoid bone. To do this, place the left side transorally in the vallecula region and continue submucosal dissection along the lingual side of the epiglottis. Due to the suspicion that the tumor is very close, it is decided to open the pharynx in the vallecula after all. This is also carried out and it quickly becomes apparent that the laryngeal side of the epiglottis is also clearly affected by the tumor and that the distance to the healthy mucosa is therefore relatively small. Now first imaging of the left side. Here along the aryepiglottic fold, but then deviate to the lateral piriform sinus wall because there is also tumor infestation here. On the right side, proceed in the same way along the lateral side of the piriform sinus because the median side is affected by small tumor islands. In the postcricoid area, the pharyngeal suture can be reunited approximately 2 cm below the arytenoid cartilage region. Further submucosal dissection caudally until the cricoid cartilage is reached. Now change and attach the tracheal rings to the newly cut skin and then place the laryngeal preparation directly caudal to the cricoid cartilage. Due to the very extensive tumor, it is now decided not to send the entire preparation for frozen section examination, but to take additional frozen sections. For this purpose, the tracheal posterior wall and the base of the tongue are resected on the right side and then several frozen sections are taken from the trachea, the postcricoid region, the base of the tongue and the piriform sinus on both sides. All frozen sections are later found to be tumor-free. The cricopharyngeal muscle is then myotomized and a size 8 Provox prosthesis is placed in the typical manner using the retraction method. This is followed by pharyngeal suturing, which initially involves inverted sutures, then a 2nd layer of the submucosal layer and finally a 3rd layer of the muscle layer with the constrictor pharyngis inferior muscle. For additional reduction of a pharyngeal fistula, 2 TachoSil swabs are placed, 1x caudally and 1x in the area of the base of the tongue, more precisely in the area of the T-suture. Finally, the apron flap is retracted and attached to the tracheostoma, 2 Redon drains are placed and the wound is closed in two layers using subcutaneous and skin sutures. The patient goes to the IOI ward after waking up due to lack of capacity. Intraoperative administration of Unacid 3 g, which should be continued for 5 days. In addition, a nasogastric tube is inserted to serve as a splint. \ No newline at end of file diff --git a/506/InvasionFront_CD3_block12_x5_y1_patient506_0.json b/506/InvasionFront_CD3_block12_x5_y1_patient506_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad73d4db52352ef927704dfc6e59336fce7fc914 --- /dev/null +++ b/506/InvasionFront_CD3_block12_x5_y1_patient506_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17465.8, + "Centroid Y µm": 7720.9, + "Num Detections": 21667, + "Num Negative": 21211, + "Num Positive": 456, + "Positive %": 2.105, + "Num Positive per mm^2": 194.28 + } +} \ No newline at end of file diff --git a/506/InvasionFront_CD3_block12_x6_y1_patient506_1.json b/506/InvasionFront_CD3_block12_x6_y1_patient506_1.json new file mode 100644 index 0000000000000000000000000000000000000000..08fc58c44ec9f27195b68a4b1a6b300c5e04d658 --- /dev/null +++ b/506/InvasionFront_CD3_block12_x6_y1_patient506_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 7970.8, + "Num Detections": 18847, + "Num Negative": 18204, + "Num Positive": 643, + "Positive %": 3.412, + "Num Positive per mm^2": 311.24 + } +} \ No newline at end of file diff --git a/506/InvasionFront_CD8_block12_x5_y1_patient506_0.json b/506/InvasionFront_CD8_block12_x5_y1_patient506_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1b04d5178430dd4d5b497a81e93c40f4950292dc --- /dev/null +++ b/506/InvasionFront_CD8_block12_x5_y1_patient506_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16641.2, + "Centroid Y µm": 5896.9, + "Num Detections": 22332, + "Num Negative": 22207, + "Num Positive": 125, + "Positive %": 0.5597, + "Num Positive per mm^2": 53.75 + } +} \ No newline at end of file diff --git a/506/InvasionFront_CD8_block12_x6_y1_patient506_1.json b/506/InvasionFront_CD8_block12_x6_y1_patient506_1.json new file mode 100644 index 0000000000000000000000000000000000000000..793f04f9a8ce35857d85a61a806cc0017d7cd5f0 --- /dev/null +++ b/506/InvasionFront_CD8_block12_x6_y1_patient506_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19214.8, + "Centroid Y µm": 5796.9, + "Num Detections": 18854, + "Num Negative": 18553, + "Num Positive": 301, + "Positive %": 1.596, + "Num Positive per mm^2": 148.36 + } +} \ No newline at end of file diff --git a/506/TumorCenter_CD3_block12_x5_y1_patient506_0.json b/506/TumorCenter_CD3_block12_x5_y1_patient506_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e01f5d6895e54ef32234761b4da5ee360f275249 --- /dev/null +++ b/506/TumorCenter_CD3_block12_x5_y1_patient506_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 2473.7, + "Num Detections": 19937, + "Num Negative": 17173, + "Num Positive": 2764, + "Positive %": 13.86, + "Num Positive per mm^2": 1302.9 + } +} \ No newline at end of file diff --git a/506/TumorCenter_CD3_block12_x6_y1_patient506_1.json b/506/TumorCenter_CD3_block12_x6_y1_patient506_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fc6cddbc2c5643e8634edd0ec401ba7f39f27c2c --- /dev/null +++ b/506/TumorCenter_CD3_block12_x6_y1_patient506_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 2423.7, + "Num Detections": 21042, + "Num Negative": 20402, + "Num Positive": 640, + "Positive %": 3.042, + "Num Positive per mm^2": 264.49 + } +} \ No newline at end of file diff --git a/506/TumorCenter_CD8_block12_x5_y1_patient506_0.json b/506/TumorCenter_CD8_block12_x5_y1_patient506_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aabefc4cdc749f79eeed6fab0a38f5d3a9ef8a77 --- /dev/null +++ b/506/TumorCenter_CD8_block12_x5_y1_patient506_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19614.6, + "Centroid Y µm": 12043.6, + "Num Detections": 20723, + "Num Negative": 17011, + "Num Positive": 3712, + "Positive %": 17.91, + "Num Positive per mm^2": 1699.6 + } +} \ No newline at end of file diff --git a/506/TumorCenter_CD8_block12_x6_y1_patient506_1.json b/506/TumorCenter_CD8_block12_x6_y1_patient506_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cb724415d4d27adc4af2880299652a2be313c5b9 --- /dev/null +++ b/506/TumorCenter_CD8_block12_x6_y1_patient506_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 22063.3, + "Centroid Y µm": 12218.5, + "Num Detections": 20507, + "Num Negative": 20393, + "Num Positive": 114, + "Positive %": 0.5559, + "Num Positive per mm^2": 46.81 + } +} \ No newline at end of file diff --git a/506/history_text.txt b/506/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/506/icd_codes.txt b/506/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2290738e6038e988ea63eeb0101a39d284e9087e --- /dev/null +++ b/506/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Seitlicher Teil des Mundbodens[C04.1 ] Bösartige Neubildung: Seitenwand des Oropharynx[C10.2 ] \ No newline at end of file diff --git a/506/ops_codes.txt b/506/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..af621019b0a39f9441e6df3556b8ff27f66f7e58 --- /dev/null +++ b/506/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Ohne Rekonstruktion[5-295.00 ] Inzision, Exzision und Destruktion in der Mundhöhle: Exzision, partiell, Mundboden[5-273.6 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument[1-620.1 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] \ No newline at end of file diff --git a/506/patient_clinical_data.json b/506/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..256960906ff60c61a08327ee90c165db320e87f8 --- /dev/null +++ b/506/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 48, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/506/patient_pathological_data.json b/506/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2e1c00a9e22250a05adf9168b58423934a60ff97 --- /dev/null +++ b/506/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "506", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/506/surgery_description.txt b/506/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..88713a57f53f8dd273517251c32c1c6f14f01a70 --- /dev/null +++ b/506/surgery_description.txt @@ -0,0 +1 @@ +Exzisionsbiopsie; Part. Resektion Pharynx, Panendoskopie diff --git a/506/surgery_report.txt b/506/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8e4389cd07e4329791dd07a4a809cc753fca11ed --- /dev/null +++ b/506/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and rigid tracheoscopy - the upper part of the trachea is visible and free - intubation by the anesthesia colleagues. Now intubation using a small bore tube. In the glossotonsillar groove on the left side, the ulcerated mass described above is seen, approx. 1 x 1 cm in diameter, but with irregular mucosal extensions, extending far anteriorly into the glossotonsillar groove and the edge of the tongue on the left side. In the further oropharynx/hypopharynx and larynx no evidence of a mass. Demonstration of findings to . He recommends primary excisional biopsy. Resection of the ulcerative mass with an appropriate safety margin by . Attempt to preserve the mucosa over the mandible. This is now exposed in a favorable position. Careful hemostasis using bipolar coagulation. The preparation is thread-marked for frozen section diagnostics. Here, the cranial and caudal resection margins are found to be moderate dysplasia cranially and carcinoma in situ caudally. Therefore indication for resection. Post-resection by using scissors. Again removal of marginal samples. These are again sent for frozen section diagnostics and are found to be tumor-free according to . Now esophagogastroscopy. Signs of reflux esophagitis here. No evidence of tumor growth. No evidence of tumor in the stomach either. Retraction of the esophagogastroscope. Inspection of the wound bed again. No bleeding here. End of the operation without bleeding, without complication. \ No newline at end of file diff --git a/507/InvasionFront_CD3_block15_x3_y4_patient507_0.json b/507/InvasionFront_CD3_block15_x3_y4_patient507_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3eb85e23a8d90f740ea37425296ed95d98799e89 --- /dev/null +++ b/507/InvasionFront_CD3_block15_x3_y4_patient507_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12918.2, + "Centroid Y µm": 20064.4, + "Num Detections": 17823, + "Num Negative": 14933, + "Num Positive": 2890, + "Positive %": 16.22, + "Num Positive per mm^2": 1268.4 + } +} \ No newline at end of file diff --git a/507/InvasionFront_CD3_block15_x4_y4_patient507_1.json b/507/InvasionFront_CD3_block15_x4_y4_patient507_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c6d37d1cc32753f798f878c1c1742ceaaa56cba8 --- /dev/null +++ b/507/InvasionFront_CD3_block15_x4_y4_patient507_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15541.8, + "Centroid Y µm": 19889.5, + "Num Detections": 19973, + "Num Negative": 15425, + "Num Positive": 4548, + "Positive %": 22.77, + "Num Positive per mm^2": 1775.8 + } +} \ No newline at end of file diff --git a/507/InvasionFront_CD8_block15_x3_y4_patient507_0.json b/507/InvasionFront_CD8_block15_x3_y4_patient507_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1c4c0f2415c30675f1dc1633c4aaf7b3171d9624 --- /dev/null +++ b/507/InvasionFront_CD8_block15_x3_y4_patient507_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11042.1, + "Centroid Y µm": 9835.2, + "Num Detections": 12459, + "Num Negative": 9705, + "Num Positive": 2754, + "Positive %": 22.1, + "Num Positive per mm^2": 1574.9 + } +} \ No newline at end of file diff --git a/507/InvasionFront_CD8_block15_x4_y4_patient507_1.json b/507/InvasionFront_CD8_block15_x4_y4_patient507_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2c3fde90910a7af94c5214a44e46d6682f8068ad --- /dev/null +++ b/507/InvasionFront_CD8_block15_x4_y4_patient507_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 9769.8, + "Num Detections": 18509, + "Num Negative": 12658, + "Num Positive": 5851, + "Positive %": 31.61, + "Num Positive per mm^2": 2345.8 + } +} \ No newline at end of file diff --git a/507/TumorCenter_CD3_block15_x3_y4_patient507_0.json b/507/TumorCenter_CD3_block15_x3_y4_patient507_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8c6c3d957c42dd381a4a6f785db21033dd232937 --- /dev/null +++ b/507/TumorCenter_CD3_block15_x3_y4_patient507_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 13268.0, + "Num Detections": 17749, + "Num Negative": 15901, + "Num Positive": 1848, + "Positive %": 10.41, + "Num Positive per mm^2": 827.13 + } +} \ No newline at end of file diff --git a/507/TumorCenter_CD3_block15_x4_y4_patient507_1.json b/507/TumorCenter_CD3_block15_x4_y4_patient507_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4048c86dc001daa34bf17b2ed65c8dd63bc4b4a5 --- /dev/null +++ b/507/TumorCenter_CD3_block15_x4_y4_patient507_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 13268.0, + "Num Detections": 18777, + "Num Negative": 15221, + "Num Positive": 3556, + "Positive %": 18.94, + "Num Positive per mm^2": 1500.0 + } +} \ No newline at end of file diff --git a/507/TumorCenter_CD8_block15_x3_y4_patient507_0.json b/507/TumorCenter_CD8_block15_x3_y4_patient507_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f86303a301e807eeb85d619ce1a3ea558b3a89f7 --- /dev/null +++ b/507/TumorCenter_CD8_block15_x3_y4_patient507_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 9944.7, + "Num Detections": 16144, + "Num Negative": 14302, + "Num Positive": 1842, + "Positive %": 11.41, + "Num Positive per mm^2": 833.17 + } +} \ No newline at end of file diff --git a/507/TumorCenter_CD8_block15_x4_y4_patient507_1.json b/507/TumorCenter_CD8_block15_x4_y4_patient507_1.json new file mode 100644 index 0000000000000000000000000000000000000000..38e01c7de1e66c0972b4a1707a3347707b915493 --- /dev/null +++ b/507/TumorCenter_CD8_block15_x4_y4_patient507_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 9944.7, + "Num Detections": 17663, + "Num Negative": 13862, + "Num Positive": 3801, + "Positive %": 21.52, + "Num Positive per mm^2": 1639.7 + } +} \ No newline at end of file diff --git a/507/history_text.txt b/507/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8cd5de66086d0f7ebb28b28bf4a345d743097aa5 --- /dev/null +++ b/507/history_text.txt @@ -0,0 +1 @@ +Patient with rapidly progressive tumorous mass in the area of the right tongue. After multiple biopsies externally and in domo, pronounced verrucous leukoplakia without evidence of carcinoma. Pathohistologically, however, a verrucous carcinoma has not been detected to date. Due to the rapid progression in size of the findings, there is now an indication for transoral tumor resection. Both the patient and the relatives/carers had ample opportunity to ask questions about the procedure beforehand. \ No newline at end of file diff --git a/507/icd_codes.txt b/507/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d2eb0924866a69a5b6c4d72558dced63455bae84 --- /dev/null +++ b/507/icd_codes.txt @@ -0,0 +1 @@ +Zungentumor[D37.0 L] \ No newline at end of file diff --git a/507/ops_codes.txt b/507/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3c16635b4d18f41e270bd7d21bf851fb54c99993 --- /dev/null +++ b/507/ops_codes.txt @@ -0,0 +1 @@ +Exzision an der Zunge[5-250.2 ] Sonstige partielle Glossektomie sonstige[5-251.xx ] Permanente Tracheotomie[5-312.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/507/patient_clinical_data.json b/507/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4412249160b2c7eebd4cd9acd8aad241810468f8 --- /dev/null +++ b/507/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 79, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 16, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/507/patient_pathological_data.json b/507/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..eceaa5fd59b8475c90a99892acce3cb94d78985c --- /dev/null +++ b/507/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "507", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/507/surgery_description.txt b/507/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7685cbbfc8bec09ca89f6b7e5d9378e489dcbdb9 --- /dev/null +++ b/507/surgery_description.txt @@ -0,0 +1 @@ +Transorale Tumorresektion, Tracheostoma diff --git a/507/surgery_report.txt b/507/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b1f6ea3f62a4b8b52c7bccd6872b7370fa7717e5 --- /dev/null +++ b/507/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesiologist. Induction of anesthesia and transition to tracheoscopy. Problem-free adjustment of the glottis without irritation and insertion after endotracheal. The mucosal conditions are unremarkable on all sides up to the bifurcation. Subsequent orotracheal intubation of the patient by the surgeon. Transition to esophagogastroscopy: First advance the endoscope into the stomach under visualization. Insufflation of the same. This reveals a typical gastric mucosal relief without irritation on all sides. Enter in inversion. Inspection of the gastroesophageal junction. This is also completely free of irritation. After desufflation, slow withdrawal of the endoscope with circular inspection of all sections of the esophagus. There is no indication of a synchronous second tumor. Remove the endoscope. Insertion of the mouth guard. Enter with the size B small bore tube. The endolarynx appears completely unremarkable. The hypopharynx is also lined on both sides with smooth mucosa on all sides and can be freely unfolded up to the tip of the piriform sinus. The same applies to the esophageal entrance and the postcricoid region. Insertion of the Jennings retractor and creation of a tongue suture. The massive exophytic, partly necrotic tumorous mass described above can be seen here. This extends from the anterior third to just below the midline as well as into the anterior base of the tongue. Lateral extension to the underside of the tongue and the floor of the mouth. The alveolar ridge appears tumor-free. As there is no clear pathohistological evidence of malignancy to date, the tumor is now circumcised with narrow resection margins. First mark the planned resection margins using the monopolar needle. Then successively cut around the tumorous mass, which is obviously growing very superficially and appears to be infiltrating further into the depths. In the area of the floor of the mouth, there are still extensive leukoplakic extensions, which are not initially included in the resection area. In the course of the resection, there is severe arterial bleeding from a branch of the lingual artery. This is first dissected bluntly from the surrounding tissue, ligated twice and then stitched around several times. The same procedure is carried out on a smaller branch of the lingual artery with a smaller caliber. Further punctual hemostasis using bipolar coagulation. Due to the arterial bleeding from a branch of the lingual artery and the relatively poor general condition of the patient, the decision was made intraoperatively to create a temporary protective tracheostoma. The patient is first repositioned. Superficial skin disinfection. Palpatory identification of the thyroid incisura, the level of the cricoid cartilage and the jugulum. Mark the planned incision in the form of an inverted T. Sharp dissection of the cutis and subcutis. Expose the infrahyoid musculature, which appears very atrophic. Insertion of the retractors. Enter the median line and dissect the severely atrophied infrahyoid musculature to the side. Palpatory identification of the cricoid cartilage. Slightly scarred alterations can be seen here, which may be due to previous thyroid surgery. Clearly more difficult preparation conditions here. Exposure of the anterior tracheal wall up to the 3rd cricoid cartilage. Due to the low laryngeal skeleton and the relatively steeply descending trachea, directly above the jugulum, the decision is now made to create a high tracheostoma. Identification of the individual tracheal clasps and opening of the trachea between the 1st and 2nd tracheal cartilage. Formation of a basal wide-stalked Björ flap. Hemostasis by means of bipolar coagulation. Subsequent successive low-tension epithelialization of the tracheostoma in the sense of a mucocutaneous anastomosis. The patient is then reintubated with an 8-gauge high-volume low-pressure tracheostomy tube. This allows the patient to be ventilated without any problems. Removal of the previously withdrawn tube and completion of the operation without complications. Final consultation with the anesthetist. Transfer of the patient to the local intensive care unit for postoperative monitoring. \ No newline at end of file diff --git a/508/InvasionFront_CD3_block4_x1_y7_patient508_0.json b/508/InvasionFront_CD3_block4_x1_y7_patient508_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2191f7d9ef0f05feb671985f86f6e27cf2e77ff9 --- /dev/null +++ b/508/InvasionFront_CD3_block4_x1_y7_patient508_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 23287.7, + "Num Detections": 19322, + "Num Negative": 17974, + "Num Positive": 1348, + "Positive %": 6.977, + "Num Positive per mm^2": 643.69 + } +} \ No newline at end of file diff --git a/508/InvasionFront_CD3_block4_x2_y7_patient508_1.json b/508/InvasionFront_CD3_block4_x2_y7_patient508_1.json new file mode 100644 index 0000000000000000000000000000000000000000..788a0172a3964524b8318907b0eb4688608eebc9 --- /dev/null +++ b/508/InvasionFront_CD3_block4_x2_y7_patient508_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8920.3, + "Centroid Y µm": 23412.6, + "Num Detections": 16120, + "Num Negative": 15088, + "Num Positive": 1032, + "Positive %": 6.402, + "Num Positive per mm^2": 545.3 + } +} \ No newline at end of file diff --git a/508/InvasionFront_CD8_block4_x1_y7_patient508_0.json b/508/InvasionFront_CD8_block4_x1_y7_patient508_0.json new file mode 100644 index 0000000000000000000000000000000000000000..edf552561dfb73ce5bab9642a6c44406f4217701 --- /dev/null +++ b/508/InvasionFront_CD8_block4_x1_y7_patient508_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3498.1, + "Centroid Y µm": 22213.2, + "Num Detections": 17974, + "Num Negative": 16776, + "Num Positive": 1198, + "Positive %": 6.665, + "Num Positive per mm^2": 562.23 + } +} \ No newline at end of file diff --git a/508/InvasionFront_CD8_block4_x2_y7_patient508_1.json b/508/InvasionFront_CD8_block4_x2_y7_patient508_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8b05a3d592630fb736ebfcf87c3f145a157998cd --- /dev/null +++ b/508/InvasionFront_CD8_block4_x2_y7_patient508_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 22313.2, + "Num Detections": 15173, + "Num Negative": 13870, + "Num Positive": 1303, + "Positive %": 8.588, + "Num Positive per mm^2": 674.96 + } +} \ No newline at end of file diff --git a/508/TumorCenter_CD3_block4_x1_y7_patient508_0.json b/508/TumorCenter_CD3_block4_x1_y7_patient508_0.json new file mode 100644 index 0000000000000000000000000000000000000000..084498d477defa84094663ac8b42a5af9d8913df --- /dev/null +++ b/508/TumorCenter_CD3_block4_x1_y7_patient508_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3398.2, + "Centroid Y µm": 17840.6, + "Num Detections": 18443, + "Num Negative": 14944, + "Num Positive": 3499, + "Positive %": 18.97, + "Num Positive per mm^2": 1472.5 + } +} \ No newline at end of file diff --git a/508/TumorCenter_CD3_block4_x2_y7_patient508_1.json b/508/TumorCenter_CD3_block4_x2_y7_patient508_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8822410e9a6b2770ed9628bbf5a5ff0d5c97ea44 --- /dev/null +++ b/508/TumorCenter_CD3_block4_x2_y7_patient508_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 17915.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/508/TumorCenter_CD8_block4_x1_y7_patient508_0.json b/508/TumorCenter_CD8_block4_x1_y7_patient508_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e88ada89e070aafc211a449ae9bb963ff846363d --- /dev/null +++ b/508/TumorCenter_CD8_block4_x1_y7_patient508_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3798.0, + "Centroid Y µm": 17190.9, + "Num Detections": 18235, + "Num Negative": 15849, + "Num Positive": 2386, + "Positive %": 13.08, + "Num Positive per mm^2": 1029.3 + } +} \ No newline at end of file diff --git a/508/TumorCenter_CD8_block4_x2_y7_patient508_1.json b/508/TumorCenter_CD8_block4_x2_y7_patient508_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3163dc639f04372a718ae0c75d7bf1add015b6d0 --- /dev/null +++ b/508/TumorCenter_CD8_block4_x2_y7_patient508_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 17365.8, + "Num Detections": 8769, + "Num Negative": 7805, + "Num Positive": 964, + "Positive %": 10.99, + "Num Positive per mm^2": 828.05 + } +} \ No newline at end of file diff --git a/508/history_text.txt b/508/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3034bf9ef925289a9b6fa89bcecea68e5c594714 --- /dev/null +++ b/508/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma in the left piriform sinus area with infiltration of the postcricoid area and infiltration of the laryngeal skeleton from the right. Therefore, the above-mentioned surgery is now indicated. \ No newline at end of file diff --git a/508/icd_codes.txt b/508/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0b3cbae91d0de18b52f016f4fb0eb0aee9e11c88 --- /dev/null +++ b/508/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] \ No newline at end of file diff --git a/508/ops_codes.txt b/508/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c80d4538573c48c8947825e33ff00479844da192 --- /dev/null +++ b/508/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/508/patient_clinical_data.json b/508/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f386c10eb7e1f85ceb72f5903d00299b4cc41432 --- /dev/null +++ b/508/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/508/patient_pathological_data.json b/508/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f35695e8da04bd18fd3dcaffa72feb3ab770baad --- /dev/null +++ b/508/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "508", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/508/surgery_description.txt b/508/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..604939bfbeb94e77e7bcd252273778a00934aba8 --- /dev/null +++ b/508/surgery_description.txt @@ -0,0 +1 @@ +Laryngektomie m. Teilpharyngektomie, Neck diss., Tracheostomaanlage, PEG-Anlage, Provoxprothese diff --git a/508/surgery_report.txt b/508/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..09cd3597abbdee2edb0baa9def0b547c768076e4 --- /dev/null +++ b/508/surgery_report.txt @@ -0,0 +1 @@ +Moving the patient to the operating theater. Actively carrying out the team time-out. Active patient identification. Introductory consultation with the anesthesia department. Induction of intubation anesthesia by colleagues. Positioning of the patient by the surgeon. First, laryngoscopy and pharyngoscopy again: After insertion of the small bore tube, the exophytic tumor, which begins in the area of the piriform sinus lateral wall at the transition to the anterior wall and infiltrates the medial wall including the arytenoid area and postcricoid area, is broad-based. Therefore indication for the above mentioned surgery confirmed. Repositioning of the patient by the surgeon. Injection of 20 ml Ultracaine 1% with adrenaline into the region of the planned apron incision. Start the operation by drawing the apron flap on both sides of the anterior edge of the sternocleidomastoid muscle to just below the cricoid medially. Separation of the cutaneous-subcutaneous tissue and platysma. Subplatysmal dissection up to the exposure of both submandibular glandulae. Suture the apron flap and expose the anterior border of the sternocleidomastoid muscle on both sides. Start with neck dissection, initially on the right side by . Expose the anterior border of the sternocleidomastoid muscle. Dissection down to the deep plexus branches. Exposure of the accessorius nerve and free preparation of the nerve. Particular care is taken to protect the nerve. Exposure of the posterior venter of the digastric muscle and the submandibular gland. Dissection of the internal jugular vein and division of the specimen into a lateral and a medial specimen. Identification of the common carotid artery and the vagus nerve. Sharp separation of the neck dissection from the cervical vascular nerve sheath. Release of regions II, III, IV and V in one cord. Renewed wound control. Hemostasis using bipolar coagulation forceps. Approach the medial part of regions II and III by exposing the facial vein and the submandibular gland. A larger lymph node metastasis in the jugulofacial angle is removed here. Irrigation with hydrogen and Ringer and bipolar coagulation of minor bleeding. Turning to the left side. Same procedure through on the left side. No primary suspicious lymph nodes are conspicuous. On the left side, also visualize all levels while sparing the vascular and nervous structures. Then proceed to laryngectomy with partial pharyngectomy on the right. Skeletonization of the pharynx and laryngeal area is performed on both sides, on the right, taking into account the carcinoma in the hypopharyngeal area. First expose the hyoid bone on both sides and separate it from the suprahyoid musculature. Dissection up to the pharyngeal tube, including the pre-epiglottic fatty tissue. Exposure of the superior cornu. Isolation of the laryngeal skeleton with separation of the constrictor pharyngis superior, first on the left, then on the right, taking into account the hypopharyngeal carcinoma. The thyroid lobe is isolated and dissected caudolaterally. The isthmus is transected and treated with puncture ligatures. Trachea is opened and epithelialized caudally using several sutures. Re-intubation and insertion of a laryngectomy tube. The larynx is then opened. The larynx is developed under visualization. On the left under maximum tension of the pharyngeal wall, on the right parts of the pharyngeal wall must also be resected. The tumor is removed at a distance of 1-1.5 cm on all sides. The tumor extends to the postcricoid, especially on the right. The pharyngeal wall can be dissected caudally. The larynx is then deposited on the trachea. The tumor specimen is marked with sutures. Due to the postcricoid growth, a mucosal margin sample is taken from the right pharyngeal wall via the postcricoid region to the border with the left pharyngeal wall. This is thread-marked and sent as a frozen section for histology. Soft tissue is also removed between the trachea and pharyngeal wall or esophageal entrance and also sent for frozen section. In the frozen section between the right pharyngeal wall and caudal still isolated tumor. Soft tissue and mucosa postcricoid free. Therefore, another extensive resection in the area of the lateral pharyngeal wall and removal of another marginal sample, which extends from the right pharyngeal wall to the postcricoid. No more tumor infiltrates in the frozen section. Thus R0 situation. A gastric tube is now inserted to splint the pharyngeal suture. Subsequent left lateral myotomy. The musculature is transected over approx. 2 - 3 cm. Then insertion of an 8 mm Provox prosthesis in the typical manner. This is placed approx. 0.5 cm lower due to the soft tissue margin between the trachea and the esophageal tube. Careful hemostasis and irrigation with Ringer's solution or hydrogen. Wound closure of the pharyngeal tube in layers with the first inverting suture. Then second inverting suture on top. Finally, third suture of the pharyngeal muscles. Sutures each with 3.0 Vicryl. Subsequent suturing of the infrahyoid musculature, which was previously dissected from the hyoid bone and folded caudal-laterally. This is also done with 3.0 Vicryl single button sutures. Lymph nodes in the level VI area were previously removed with the laryngeal preparation. Then again irrigation and careful hemostasis. Wound closure in layers on both sides of the neck with insertion of a Redon drain in each case. Epithelialization of the tracheostoma. Finally, insertion of a 9 mm tracheostomy tube. The procedure was completed without complications. Overall cT4a cN2c laryngeal carcinoma. Patient transferred to the intensive care unit for monitoring. Please feed via the PEG tube already inserted beforehand. This for 10 days, then gruel and, if necessary, diet build-up. Please continue antibiotics with Unacid for one week. After receiving the final histology, presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/509/InvasionFront_CD3_block11_x5_y9_patient509_0.json b/509/InvasionFront_CD3_block11_x5_y9_patient509_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3edea9a10a1e166c3a952a547a3f01f50ce253a3 --- /dev/null +++ b/509/InvasionFront_CD3_block11_x5_y9_patient509_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15791.6, + "Centroid Y µm": 21438.6, + "Num Detections": 15792, + "Num Negative": 12783, + "Num Positive": 3009, + "Positive %": 19.05, + "Num Positive per mm^2": 1642.3 + } +} \ No newline at end of file diff --git a/509/InvasionFront_CD3_block11_x6_y9_patient509_1.json b/509/InvasionFront_CD3_block11_x6_y9_patient509_1.json new file mode 100644 index 0000000000000000000000000000000000000000..91915626a19bdce02f0b3cf641ecbdeb5bd910de --- /dev/null +++ b/509/InvasionFront_CD3_block11_x6_y9_patient509_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 21338.7, + "Num Detections": 20344, + "Num Negative": 15831, + "Num Positive": 4513, + "Positive %": 22.18, + "Num Positive per mm^2": 2014.3 + } +} \ No newline at end of file diff --git a/509/InvasionFront_CD8_block11_x5_y9_patient509_0.json b/509/InvasionFront_CD8_block11_x5_y9_patient509_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3350265a6b4500debcf56324f9e132508002db83 --- /dev/null +++ b/509/InvasionFront_CD8_block11_x5_y9_patient509_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18763.9, + "Centroid Y µm": 32861.6, + "Num Detections": 2656, + "Num Negative": 2395, + "Num Positive": 261, + "Positive %": 9.827, + "Num Positive per mm^2": 764.53 + } +} \ No newline at end of file diff --git a/509/TumorCenter_CD3_block11_x6_y9_patient509_1.json b/509/TumorCenter_CD3_block11_x6_y9_patient509_1.json new file mode 100644 index 0000000000000000000000000000000000000000..318cbaba2b679da9b3ed86b380e43d9e73fb50b7 --- /dev/null +++ b/509/TumorCenter_CD3_block11_x6_y9_patient509_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21251.2, + "Centroid Y µm": 22613.0, + "Num Detections": 11271, + "Num Negative": 8436, + "Num Positive": 2835, + "Positive %": 25.15, + "Num Positive per mm^2": 1922.3 + } +} \ No newline at end of file