diff --git a/737/surgery_description.txt b/737/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..616f7f11656e4ee458c7f4c718c575cda88127cc --- /dev/null +++ b/737/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Left-sided neck dissection, Tracheotomy, PEG placement diff --git a/739/InvasionFront_CD8_block7_x3_y7_patient739_0.json b/739/InvasionFront_CD8_block7_x3_y7_patient739_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3c304734994e2f15f0d7faa6dde603f9f80e2d70 --- /dev/null +++ b/739/InvasionFront_CD8_block7_x3_y7_patient739_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11943.7, + "Centroid Y µm": 17890.5, + "Num Detections": 14661, + "Num Negative": 14292, + "Num Positive": 369, + "Positive %": 2.517, + "Num Positive per mm^2": 169.58 + } +} \ No newline at end of file diff --git a/739/InvasionFront_CD8_block7_x4_y7_patient739_1.json b/739/InvasionFront_CD8_block7_x4_y7_patient739_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0342d95c4826f551365d4bde484270f63af7db1d --- /dev/null +++ b/739/InvasionFront_CD8_block7_x4_y7_patient739_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14717.2, + "Centroid Y µm": 18190.4, + "Num Detections": 16840, + "Num Negative": 15888, + "Num Positive": 952, + "Positive %": 5.653, + "Num Positive per mm^2": 439.25 + } +} \ No newline at end of file diff --git a/739/TumorCenter_CD8_block7_x4_y7_patient739_1.json b/739/TumorCenter_CD8_block7_x4_y7_patient739_1.json new file mode 100644 index 0000000000000000000000000000000000000000..427ce7d69b537e868db31f62fea394103cb1fe06 --- /dev/null +++ b/739/TumorCenter_CD8_block7_x4_y7_patient739_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 17615.7, + "Num Detections": 21792, + "Num Negative": 21594, + "Num Positive": 198, + "Positive %": 0.9086, + "Num Positive per mm^2": 80.88 + } +} \ No newline at end of file diff --git a/744/surgery_report.txt b/744/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a30c43c00d8eb4ac04dee1b01dcaef7b9d72cc0 --- /dev/null +++ b/744/surgery_report.txt @@ -0,0 +1 @@ +Repeated pharyngoscopy and laryngoscopy as well as oral cavity inspection: The tumor can be seen, which is located exophytically in the body of the tongue, does not cross the midline, extends over the floor of the mouth onto the glossoalveolar fold, onto the tonsillar lobe, runs downwards to the end of the tonsil. Infiltration also towards the base of the tongue. This confirms the indication. The next step is transoral tumor resection. The tumor is cut around on all sides with a safety margin of 1-1.5 cm. The anterior palatal arch falls, the posterior palatal arch remains, part of the pharyngeal wall falls, the lower jaw is exposed, the posterior center of the tongue body is resected up to the midline. Parts of the base of the tongue in the upper 2/3 of the base of the tongue are also resected. The lingual nerve is preserved. Removal of the specimen in one piece, suture marking. Extra margin sample basally in the base of the tongue. Send in for frozen section. Preparation in healthy tissue, also marginal sample, thus R0 resection. Careful hemostasis. Measurement of the defect. Neck dissection on the left through and : incision in typical manner. Exposure of the sternocleidomastoid muscle, omohyoid muscle, digastric muscle and the infrahyoid musculature. Subsequent clearing of levels II to IV in a typical manner. Exposure of the internal jugular vein, facial vein, exposure of the internal and external carotid artery. Exposure of the accessory nerve, vagus nerve and hypoglossal nerve. Finally, careful hemostasis. Neck dissection on the right side by and : Same procedure as on the opposite side. Resection of the submandibular gland and levels Ib and Ia. Exposure and preservation of the facial artery, superior thyroid artery and facial vein with several outlets. Also visualization of the middle thyroid vein. This results in a level I to V evacuation on the left. Branches of the cervical plexus are exposed and preserved. Exposure of all structures as on the left side. Finally, careful hemostasis. Then elevation of the radial flap: marking of the flap length 12 cm to 12.5 cm x 6.5 cm width. Cut around the flap ulnarly, extending it cranially to the olecranon. Lifting of ulnar subfascial. Exposure of the superficial venous system, which is included. Subsequent exposure of the vascular pedicle, which is typically located on the brachioradialis muscle. Then radial incision of the flap. Subfascial elevation. Exposure of the cutaneous nerve to the lateral brachii and preservation. Distal exposure of several veins with ligation. Distal exposure of the end of the vascular pedicle. Exposure of the radial vein and radial artery. Clamp for a few minutes. Saturation always at 100 %. Then cut and treat with puncture ligatures distally and proximally. Lift the flap subfascially along the pedicle. Outgoing vessels are clipped or treated bipolar. Dissection of the vascular pedicle up to the crook of the elbow. Exposure of surface connection, deep venous system. V. cephalica is exposed in a typical manner, as well as larger veins branching off medially, a total of 2 vein ends for the anastomosis. Additional dissection of the confluence, which is also elevated and would be suitable. Exposure of the radial artery up to the entry into the brachial artery. Exposure of the previously outgoing vein and interosseous artery. This is clamped for a few minutes, no change in saturation here. Deposition and clipping or ligation. The flap is then removed and the brachial artery is treated with 6-0 Vascufil sutures. Ligation of the proximal veins. Spraying the flap with heparin solution. To cover the defect on the left forearm, split skin, thickness 0.7-0.8 mm, is removed from the thigh using the dermatome. Split skin is successively incorporated into the defect. Complete, tension-free coverage. Cranial in typical manner. Wound closure in layers. Saturation on the arm always sufficient. Between 95 and 100 %. The superficial skin defect on the thigh is treated with a hydrogel dressing. The forearm is treated with .................-Relex dressing. Then apply compresses and wrap in absorbent cotton. Fit Cramer splint and wrap in elastic bandage in functional site. Application of an arm. Saturation still > 95 %. Subsequent insertion of the radial flap into the enoral mouth defect. This is done using single Vicryl 3-0 button sutures. The flap is sutured successively into the defect without tension, partly with the sutures in place and partly with direct sutures. The flap pedicle is passed through a large tunnel. For this purpose, the digastric muscle was severed and a 3 QF tunnel was created. Tension-free and complete defect coverage. Subsequent vascular suture: facial artery not suitable as the lumen is too small. A. thyroidea superior is selected. Conditioning. Also conditioning of the radial artery. This is thickened in some places in the sense of intimal fibrosis. Fish-mouth-like incision of the superior thyroid artery, thereby equalizing the lumen. Suturing with single 8-button Ethilon sutures. After opening the clamps, good arterial flow and good venous return. Then conditioning of the V. thyroidea media and an outlet from the V. facialis. Conditioning of the 2 outlets from the superficial venous system. One outlet is anastomosed with Coupler 3.0, the second outlet with Coupler 2.5. After opening the clamps, good venous return in each case. Positive smear phenomenon. Finally, clipping of the confluence and several outlets from the superficial venous system close to the outlet. Inspection of the flap. This is well perfused. Then layered wound closure of the skin wound on the right with insertion of 2 flaps after careful hemostasis and irrigation. Layered wound closure of the skin wound on the left after irrigation and hemostasis with insertion of a Redon drainage. On the right, a marking suture is placed above the vascular pedicle for Doppler control. An 8-gauge tracheostomy tube is inserted and fixed with sutures. The flap is inspected again. This is well perfused. The procedure is completed without complications. Patient goes to the intensive care unit postoperatively ventilated. Ventilation for one night. Please continue antibiotics that were started intraoperatively for one week. Heparin, which was started intraoperatively at 500 E/h, should be continued for 5 days. Check the flap clinically and, if necessary, by Doppler according to the scheme for 5 days. Feeding for 10 days via the inserted PEG tube, followed by a gruel and then, if necessary, a diet. Overall cT3 oral cavity oropharyngeal carcinoma on the right. Awaiting the histological findings. Please leave the forearm bandage closed for 1 week, then change the bandage for the first time if there are no unusual findings. \ No newline at end of file diff --git a/745/TumorCenter_CD8_block3_x6_y10_patient745_1.json b/745/TumorCenter_CD8_block3_x6_y10_patient745_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3aa2154ef519d47ead6a96c59edc253997933ac2 --- /dev/null +++ b/745/TumorCenter_CD8_block3_x6_y10_patient745_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18515.2, + "Centroid Y µm": 26635.9, + "Num Detections": 18080, + "Num Negative": 15774, + "Num Positive": 2306, + "Positive %": 12.75, + "Num Positive per mm^2": 992.79 + } +} \ No newline at end of file diff --git a/745/history_text.txt b/745/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/745/icd_codes.txt b/745/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..22b7e89d0b08671770466d5f0e998800cfbe05e4 --- /dev/null +++ b/745/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/745/patient_clinical_data.json b/745/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fe9dcaedd8562cb99670cca13f7b94697ed0d5b4 --- /dev/null +++ b/745/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 50, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/745/patient_pathological_data.json b/745/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..eb33d9c97f3708892ea7eaaa54d1e539d2f93ed0 --- /dev/null +++ b/745/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "745", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 19.0 +} \ No newline at end of file diff --git a/745/surgery_description.txt b/745/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4ba19f9b5d1acee4dbc930a9571abdf6585b7521 --- /dev/null +++ b/745/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Defect coverage, Free flap (Radial), PEG placement, Tracheotomy diff --git a/745/surgery_report.txt b/745/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d36fe35bf2359512b47a46b82c0172cf9aa78dde --- /dev/null +++ b/745/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by anesthesia colleagues. Sterile washing and draping of the abdominal area. Placement of a PEG using the thread pull-through method with good diaphanoscopy without any problems. Injection in the neck and sterile washing and draping. Insertion of the mouth blocker and start of transoral tumor resection. There is an exophytic mass in the tonsil lobe, which passes over the glossotonsillar groove to the base and edge of the tongue and the floor of the mouth on the right side. Start of tumor resection in the area of the soft palate with the electric needle. Dissection up to the tonsil bed. The soft tissues of the throat are reached relatively quickly here. Dissection up to the base of the tongue and dissection at the edge of the tongue. Ultimately, the tumor cannot be completely removed transorally, so it is transferred for neck dissection. Creation of an apron flap in the usual manner. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the digaster and the submandibular gland. Exposure of the cervical vascular sheath and the accessorius and hypoglossal nerves. Then evacuation of the neck levels I b to V a while sparing the plexus branches. Removal of the submandibular gland. Cut through the digastric muscle and enter the oropharynx. Now pull through the tumor and complete the tumor resection from transcervical. Remove marginal samples and send the specimen on cork for histology. All marginal samples are free of tumor and carcinoma in situ. Moderate dysplasia was found in the soft palate area. Further resection is recommended here. This is carried out and sent for final histology. Finally, clearing of level I a on the right side. Neck dissection on the left and tracheotomy by . Exposure of the anterior border of the sternocleidomastoid muscle and exposure of the omohyoid muscle. Dissection of the omohyoid muscle to the cranial side of the digaster muscle. Exposure of the accessorius nerve. Locate the submandibular gland and expose the gland. Fold up the gland and expose the digaster muscle. Dissection in the direction of the hyoid bone and mastoid. Dissection of the internal jugular vein. Free dissection of the vein from caudal to cranial. Easy dissection and visualization of the facial vein. Locating and preserving the hypoglossal nerve at the jugulofacial angle. Careful removal of the medial neck preparation while preserving all structures. Dissection of the lateral neck preparation and removal of this while preserving the plexus branches. No increased bleeding, no chyle. Tracheotomy: Marking of the landmarks and dissection through the prelaryngeal muscles in the linea alba onto the cricoid cartilage. Push the prelaryngeal musculature to the side. Exposure of the thyroid gland and undermining of the thyroid gland with the Pean clamp. Bipolar coagulation of the thyroid gland and careful transection of the thyroid gland. Move the thyroid gland to the side and expose the trachea. Opening of the trachea between the 2nd and 3rd interspace. Entering the trachea and creating a Björ flap. Suturing of the tracheostoma at the caudal edge. Now hand over the operation to the reconstruction team with . First measure the required dimensions of the flap, these are max. 12 cm long and 10 cm wide. The flap is then raised on the radialis flap on the left forearm: Mark the flap dimensions according to the required size and three-dimensional configuration. Then recut the flap, initially ulnarly. The incision is extended in the direction of the ulnar flexion. Exposure of the superficial venous system, which is integrated into the flap. Lift the flap initially from the ulnar side. Subsequent incision also from the radial side with subfascial and ulnar elevation of the flap. The lateral antebrachial cutaneous nerve is exposed and preserved as far as possible. Distal exposure of the radial artery, which is clamped off. .................................. Lateral exposure of the superficial venous system up to the crook of the elbow. This shows the cephalic vein with two good ends, a good connection to the deep venous system. Depiction of the deep venous system. Exposure of the vascular pedicle. Subsequent transection of the radial artery with good saturation. This is treated proximally and distally with 4.0 Prolene single-button stitches. Lift the flap subfascially. Outgoing vessels are coagulated or clipped. Dissection up to the crook of the elbow. After clamping, cut the interosseous artery. Exposure of the venous confluence, which is lifted with a total of 2 ends. The veins, which are ligated, are then removed and the artery, which is supplied with a 6.0 Prolene suture in the area of the end of the brachial artery, is removed. Flush the flap with heparin solution. Subsequent insertion of the flap into the defect. Successive suturing of the flap, first from the transcervical and then from the transoral side, partly with the sutures in place using 3.0 Vicryl single-button sutures. The result is a tension-free, complete and anatomically correct reconstruction. Flap pedicle is prepared. The radial artery and 2 ends of the cephalic vein are conditioned, as are the superior thyroid artery, the middle thyroid vein and the external jugular vein. The arteries are sutured using 9.0 Ethilon single-button sutures. The veins are anastomosed using 3 and 2 couplers. Positive smear phenomenon after opening the clamps. Arterial flow after opening the clamp before the vein anastomosis is also regular. Subsequent careful irrigation of the wound area and hemostasis. Wound closure of the neck sides is carried out by suturing the skin on the tracheostoma area and inserting Redon drainage on the left and 2 flaps on the right. The cannula is fixed with sutures. Flap vital after repeated transoral inspection. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue the antibiotic treatment with Unacid for 1 week. Nutrition via the inserted PEG tube until the 7th-10th day, then gruel and, if necessary, diet build-up. Regular checks of the flap perfusion clinically or via the Doppler in the neck area in the area of the marking threads. Checks according to the schedule for 5 days. Wait for the final histology and presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/746/InvasionFront_CD8_block4_x1_y12_patient746_0.json b/746/InvasionFront_CD8_block4_x1_y12_patient746_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e58cfa8a1441e5f44a4725a96e6a434a7ecf0407 --- /dev/null +++ b/746/InvasionFront_CD8_block4_x1_y12_patient746_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 34894.4, + "Num Detections": 26054, + "Num Negative": 21796, + "Num Positive": 4258, + "Positive %": 16.34, + "Num Positive per mm^2": 1688.4 + } +} \ No newline at end of file diff --git a/746/InvasionFront_CD8_block4_x2_y12_patient746_1.json b/746/InvasionFront_CD8_block4_x2_y12_patient746_1.json new file mode 100644 index 0000000000000000000000000000000000000000..33168c96c0edb5a5a1a20ea3e01e61f9c6c10bba --- /dev/null +++ b/746/InvasionFront_CD8_block4_x2_y12_patient746_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 34931.5, + "Num Detections": 27646, + "Num Negative": 25731, + "Num Positive": 1915, + "Positive %": 6.927, + "Num Positive per mm^2": 754.89 + } +} \ No newline at end of file diff --git a/746/TumorCenter_CD3_block4_x2_y12_patient746_1.json b/746/TumorCenter_CD3_block4_x2_y12_patient746_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7ed5eeeb6828028dc5eebc0a976567dab95bf16e --- /dev/null +++ b/746/TumorCenter_CD3_block4_x2_y12_patient746_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 30858.7, + "Num Detections": 22066, + "Num Negative": 19596, + "Num Positive": 2470, + "Positive %": 11.19, + "Num Positive per mm^2": 1090.9 + } +} \ No newline at end of file diff --git a/746/TumorCenter_CD8_block4_x1_y12_patient746_0.json b/746/TumorCenter_CD8_block4_x1_y12_patient746_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b9cc5a5a219e27ccf1e8508d8d813557d1b02685 --- /dev/null +++ b/746/TumorCenter_CD8_block4_x1_y12_patient746_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3473.2, + "Centroid Y µm": 30483.9, + "Num Detections": 27105, + "Num Negative": 23865, + "Num Positive": 3240, + "Positive %": 11.95, + "Num Positive per mm^2": 1168.2 + } +} \ No newline at end of file diff --git a/746/TumorCenter_CD8_block4_x2_y12_patient746_1.json b/746/TumorCenter_CD8_block4_x2_y12_patient746_1.json new file mode 100644 index 0000000000000000000000000000000000000000..70d6355776bb6fa944bddfff29e732af857401a1 --- /dev/null +++ b/746/TumorCenter_CD8_block4_x2_y12_patient746_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 30533.8, + "Num Detections": 23331, + "Num Negative": 22333, + "Num Positive": 998, + "Positive %": 4.278, + "Num Positive per mm^2": 430.84 + } +} \ No newline at end of file diff --git a/746/history_text.txt b/746/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..02bd69c58513041bafb7b00084f7e6868f5c5058 --- /dev/null +++ b/746/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed cT2 cN2a tongue base carcinoma on the left side. There is a post-panendoscopy in domo <2016>. Histologically a squamous cell carcinoma (G2, p16 positive) was confirmed. In the B-scan sonographic examination of the head and soft tissues of the neck performed by us, a cystic mass in region II on the left shows a cN2a neck status. Based on the diagnosis, the above-mentioned operation is indicated. The patient was informed in detail about the procedure and had sufficient time to ask questions. \ No newline at end of file diff --git a/746/icd_codes.txt b/746/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/746/ops_codes.txt b/746/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb3532e97926088d94b801195cd00bc81fd33852 --- /dev/null +++ b/746/ops_codes.txt @@ -0,0 +1 @@ +Inzision Zungengrund[5-250.x ] Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Anwendung eines komplexen OP-Roboters (Zusatzkode)[5-987.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/746/patient_clinical_data.json b/746/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8db475d61abc70c1b4962af72e72c6f3b4335f06 --- /dev/null +++ b/746/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/746/patient_pathological_data.json b/746/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1241632cade73d1ed06ca072072472982a977a91 --- /dev/null +++ b/746/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "746", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN3b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/746/surgery_description.txt b/746/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..393240c3092e220c00ef3adf234f5456d50a6d1a --- /dev/null +++ b/746/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection TORS, Bilateral neck dissection, PEG placement, Panendoscopy diff --git a/746/surgery_report.txt b/746/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0e9ffb9f2d3e14805abde99eb7c8005869f4f921 --- /dev/null +++ b/746/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater. Carry out another panendoscopy. Head declination by the surgeon and insertion with the Kleinsasser tube size C. An approx. 3 cm large, partially exophytic mass is seen extending from the lower tonsil pole into the base of the tongue. The midline is not crossed. The piriform sinus is tumor-free. The other findings in the mirror are unremarkable. Perform a flexible gastroesophagoscopy. The mucosal conditions are also unremarkable here. Insertion of a PEG tube using the thread pull-through method in the usual manner without complications. Insertion of the Spantex. Insertion of the mouth blocker and docking of the robotic arms. Adjustment of the robotic arms and positioning of the tumor under endoscopic control. Start with tumor resection from the cranial part to the caudal side. This is done without further bleeding. Removal of the tumor specimen. Obtain several representative marginal samples from the tumor bed. Sending for frozen section diagnostics: The frozen sections are tumor-free. Repeated site check: dry wound conditions on all sides, no evidence of bleeding. Removal of the robotic arms and completion of the tumor resection without complications. Now injection of Supra and wiping of the neck for neck dissection. Start of neck dissection on the left side. Separation of the skin and subcutaneous tissue as well as the platysma at the anterior margin of the sternocleidomastoid muscle 2 QF below the mandible. Dissection of a subplatysmal flap. Identification of the submandibular gland. Dissection along the muscle in depth down to the deep cervical fascia. The plexus branches of the cervical plexus are spared. Identification of the accessorius nerve. There is a metastasis-like mass lateral to the nerve, adjacent to the digastric muscle. From the underside, the internal jugular vein can be reliably separated from the mass by dissection. The accessory nerve can also be safely removed from the metastasis. There are no signs of infiltration. Now detach the remaining neck preparation from the depths while sparing the plexus branches. Identification of the common carotid artery and the vagus nerve. These can be spared without any problems. Identification of the hypoglossal nerve. This should also be spared. Placement of a 10-gauge Redon drain and two-layer wound closure. Now turn to the right side. Here also incision of the skin and subcutaneous tissue. Incision of the platysma and creation of a platysmal flap. Identification of the submandibular gland. Removal of the submandibular gland from its glandular bed. Identification of the digastric muscle. Identification of the accessorius nerve. Division of the neck preparation on the internal jugular vein. Identification of the vagus nerve and common carotid artery. Detachment of the neck preparation on the right side from the depth while sparing the plexus branches. No metastasis-suspicious nodes are visible on the right side. Completion of the neck dissection without complications. As on the left side, the right side is also irrigated with hydrogen and Ringer. Dry wound conditions at the end of the operation. Placement of a 10-gauge Redon drain and two-layer wound closure. The operation is completed without complications. \ No newline at end of file diff --git a/747/InvasionFront_CD3_block16_x1_y5_patient747_0.json b/747/InvasionFront_CD3_block16_x1_y5_patient747_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b8ba96c0d1fa4f442082ed7950d5a429bf8a8a8 --- /dev/null +++ b/747/InvasionFront_CD3_block16_x1_y5_patient747_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4454.5, + "Centroid Y µm": 17002.3, + "Num Detections": 14000, + "Num Negative": 13257, + "Num Positive": 743, + "Positive %": 5.307, + "Num Positive per mm^2": 323.39 + } +} \ No newline at end of file diff --git a/747/InvasionFront_CD3_block16_x2_y5_patient747_1.json b/747/InvasionFront_CD3_block16_x2_y5_patient747_1.json new file mode 100644 index 0000000000000000000000000000000000000000..11ace9e1d16acf94ae5edec25d1cf3776113a71c --- /dev/null +++ b/747/InvasionFront_CD3_block16_x2_y5_patient747_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7086.6, + "Centroid Y µm": 16923.7, + "Num Detections": 22015, + "Num Negative": 21432, + "Num Positive": 583, + "Positive %": 2.648, + "Num Positive per mm^2": 231.88 + } +} \ No newline at end of file diff --git a/747/InvasionFront_CD8_block16_x1_y5_patient747_0.json b/747/InvasionFront_CD8_block16_x1_y5_patient747_0.json new file mode 100644 index 0000000000000000000000000000000000000000..99c48c1cecc8dffcb58669d7b0c01877cb631e12 --- /dev/null +++ b/747/InvasionFront_CD8_block16_x1_y5_patient747_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3483.5, + "Centroid Y µm": 12088.0, + "Num Detections": 17305, + "Num Negative": 16676, + "Num Positive": 629, + "Positive %": 3.635, + "Num Positive per mm^2": 291.79 + } +} \ No newline at end of file diff --git a/747/InvasionFront_CD8_block16_x2_y5_patient747_1.json b/747/InvasionFront_CD8_block16_x2_y5_patient747_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b05eac810aaddea8d6df2bb2ca3bd16961d4ba15 --- /dev/null +++ b/747/InvasionFront_CD8_block16_x2_y5_patient747_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6240.3, + "Centroid Y µm": 12118.3, + "Num Detections": 23988, + "Num Negative": 23626, + "Num Positive": 362, + "Positive %": 1.509, + "Num Positive per mm^2": 141.57 + } +} \ No newline at end of file diff --git a/747/TumorCenter_CD3_block16_x1_y5_patient747_0.json b/747/TumorCenter_CD3_block16_x1_y5_patient747_0.json new file mode 100644 index 0000000000000000000000000000000000000000..56faecabfbd29f7bd7fc418ed58ef4afc6541c91 --- /dev/null +++ b/747/TumorCenter_CD3_block16_x1_y5_patient747_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4422.7, + "Centroid Y µm": 12393.4, + "Num Detections": 21408, + "Num Negative": 20229, + "Num Positive": 1179, + "Positive %": 5.507, + "Num Positive per mm^2": 445.28 + } +} \ No newline at end of file diff --git a/747/TumorCenter_CD3_block16_x2_y5_patient747_1.json b/747/TumorCenter_CD3_block16_x2_y5_patient747_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ad032bb5f67cf4115c95b7b0465650bc029b1a8f --- /dev/null +++ b/747/TumorCenter_CD3_block16_x2_y5_patient747_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 12568.3, + "Num Detections": 23093, + "Num Negative": 21623, + "Num Positive": 1470, + "Positive %": 6.366, + "Num Positive per mm^2": 543.21 + } +} \ No newline at end of file diff --git a/747/TumorCenter_CD8_block16_x1_y5_patient747_0.json b/747/TumorCenter_CD8_block16_x1_y5_patient747_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3891985a0548bf3a2a538495e3b465121ac99131 --- /dev/null +++ b/747/TumorCenter_CD8_block16_x1_y5_patient747_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3423.2, + "Centroid Y µm": 12868.2, + "Num Detections": 22311, + "Num Negative": 21602, + "Num Positive": 709, + "Positive %": 3.178, + "Num Positive per mm^2": 273.83 + } +} \ No newline at end of file diff --git a/747/TumorCenter_CD8_block16_x2_y5_patient747_1.json b/747/TumorCenter_CD8_block16_x2_y5_patient747_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e129733cc51e3ab02931fb3c288df06bed92fe1c --- /dev/null +++ b/747/TumorCenter_CD8_block16_x2_y5_patient747_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 12893.2, + "Num Detections": 25076, + "Num Negative": 24670, + "Num Positive": 406, + "Positive %": 1.619, + "Num Positive per mm^2": 153.12 + } +} \ No newline at end of file diff --git a/747/history_text.txt b/747/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b4441998c6a538b0213797c415fbd2f4d374e3ce --- /dev/null +++ b/747/history_text.txt @@ -0,0 +1 @@ +The patient presented with a painful mass on the left edge of the tongue. A biopsy was taken externally, which revealed a G2 squamous cell carcinoma. Hence the indication for the above-mentioned procedure. \ No newline at end of file diff --git a/747/icd_codes.txt b/747/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/747/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/747/ops_codes.txt b/747/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..221d62347fccba9e90d18b5b00e8396f9e5dedb3 --- /dev/null +++ b/747/ops_codes.txt @@ -0,0 +1 @@ +Inzision erkranktes Gewebe Zungenrand[5-250.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/747/patient_clinical_data.json b/747/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..055aa69cbba14071eb27ace4b26b7fa10954f4d9 --- /dev/null +++ b/747/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 67, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/747/patient_pathological_data.json b/747/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3dead1182486fbb4938a798e69dcf085166f6122 --- /dev/null +++ b/747/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "747", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/747/surgery_description.txt b/747/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ab6802cce3ba6d869b2571e7fced1445d1df0d69 --- /dev/null +++ b/747/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy, Panendoscopy diff --git a/747/surgery_report.txt b/747/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..312b28ba640a294406c8695c6ed80e51d84a0105 --- /dev/null +++ b/747/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia by the anesthetist. Then the tracheoscopy is performed. Enter with the 0-degree scope and inspect the vocal folds and trachea up to the carina. Inconspicuous conditions on all sides. Intubation by the surgeon. Entry with the flexible esophagoscope and inspection of the esophagus and stomach. No abnormalities here. Intubation with the Kleinsasser tube and inspection of the oropharynx, tonsil larynx, posterior pharyngeal wall, base of tongue, all unremarkable. Inspection of the hypopharynx and in particular the left side, as the patient reported pain here. Even on close inspection, no mucosal lesion or mass was found. The posterior pharyngeal wall, the hypopharyngeal side walls, the piriform sinuses, the postcricoid region and the esophageal entrance are completely unremarkable. Adjustment of the arytenoid region and inspection of the arytenoid cusps and the interaryngeal region. Inconspicuous on all sides. Inspection of the glottic plane, the pocket folds, morgue sinus, no mass here either. Now insertion of a covered retractor and inspection of the oral cavity. Apart from the mass on the tongue, no other lesion can be seen here either. The mass on the tongue is approx. 0.5 cm in diameter. It is cut around on all sides with a safety margin of 1 cm. The specimen is sent to histology in one piece, marked with a suture. Hemostasis with bipolar coagulation and completion of the procedure. \ No newline at end of file diff --git a/748/InvasionFront_CD3_block22_x3_y11_patient748_0.json b/748/InvasionFront_CD3_block22_x3_y11_patient748_0.json new file mode 100644 index 0000000000000000000000000000000000000000..45b9a088322ee67fb746be2334a0e37d64715197 --- /dev/null +++ b/748/InvasionFront_CD3_block22_x3_y11_patient748_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11868.7, + "Centroid Y µm": 39104.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/748/InvasionFront_CD3_block22_x4_y11_patient748_1.json b/748/InvasionFront_CD3_block22_x4_y11_patient748_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5239c850b59c050f9aa9cc48dcb9d5657e56c914 --- /dev/null +++ b/748/InvasionFront_CD3_block22_x4_y11_patient748_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14392.4, + "Centroid Y µm": 39154.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/748/InvasionFront_CD8_block22_x3_y11_patient748_0.json b/748/InvasionFront_CD8_block22_x3_y11_patient748_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dfbd332b5c8a31d9d13cc5ef0c6bd4e7853f7420 --- /dev/null +++ b/748/InvasionFront_CD8_block22_x3_y11_patient748_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14369.3, + "Centroid Y µm": 27096.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/748/InvasionFront_CD8_block22_x4_y11_patient748_1.json b/748/InvasionFront_CD8_block22_x4_y11_patient748_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1cfcb68c25035fe4a97fa25976f3aff43d97a710 --- /dev/null +++ b/748/InvasionFront_CD8_block22_x4_y11_patient748_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16807.5, + "Centroid Y µm": 27087.7, + "Num Detections": 2815, + "Num Negative": 2599, + "Num Positive": 216, + "Positive %": 7.673, + "Num Positive per mm^2": 515.58 + } +} \ No newline at end of file diff --git a/748/TumorCenter_CD3_block22_x3_y11_patient748_0.json b/748/TumorCenter_CD3_block22_x3_y11_patient748_0.json new file mode 100644 index 0000000000000000000000000000000000000000..495e6d24dcf5fcce06f95f8a4ef62bf389b24bd1 --- /dev/null +++ b/748/TumorCenter_CD3_block22_x3_y11_patient748_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10762.6, + "Centroid Y µm": 27999.3, + "Num Detections": 8433, + "Num Negative": 7965, + "Num Positive": 468, + "Positive %": 5.55, + "Num Positive per mm^2": 309.6 + } +} \ No newline at end of file diff --git a/748/TumorCenter_CD3_block22_x4_y11_patient748_1.json b/748/TumorCenter_CD3_block22_x4_y11_patient748_1.json new file mode 100644 index 0000000000000000000000000000000000000000..95c12f6f0b966442b3ff2ce3033ab7b6b06089e9 --- /dev/null +++ b/748/TumorCenter_CD3_block22_x4_y11_patient748_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13505.3, + "Centroid Y µm": 28010.2, + "Num Detections": 19819, + "Num Negative": 19372, + "Num Positive": 447, + "Positive %": 2.255, + "Num Positive per mm^2": 202.28 + } +} \ No newline at end of file diff --git a/748/TumorCenter_CD8_block22_x3_y11_patient748_0.json b/748/TumorCenter_CD8_block22_x3_y11_patient748_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fd0f1425a299f7aa1f5a04b033ebe0a0f083508c --- /dev/null +++ b/748/TumorCenter_CD8_block22_x3_y11_patient748_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12968.1, + "Centroid Y µm": 37805.0, + "Num Detections": 8332, + "Num Negative": 7833, + "Num Positive": 499, + "Positive %": 5.989, + "Num Positive per mm^2": 443.52 + } +} \ No newline at end of file diff --git a/748/TumorCenter_CD8_block22_x4_y11_patient748_1.json b/748/TumorCenter_CD8_block22_x4_y11_patient748_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f768450c580b383169ca3ae4a75fd90eb164b374 --- /dev/null +++ b/748/TumorCenter_CD8_block22_x4_y11_patient748_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15666.7, + "Centroid Y µm": 37979.9, + "Num Detections": 19761, + "Num Negative": 18737, + "Num Positive": 1024, + "Positive %": 5.182, + "Num Positive per mm^2": 448.49 + } +} \ No newline at end of file diff --git a/748/history_text.txt b/748/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..439e0eeeabd8074b5c7899a69997922569326f2c --- /dev/null +++ b/748/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: After partial laryngectomy and radiotherapy in 2006, histologically confirmed tumor in the area of the glottis and subglottis in the sense of a second carcinoma. After appropriate explanation to the patient, indication for surgical intervention. No indication for neck revision in the absence of lymph nodes in the area of both sides of the neck. \ No newline at end of file diff --git a/748/icd_codes.txt b/748/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c275d6e97dc4d93d654e1da971d07fda24ddde54 --- /dev/null +++ b/748/icd_codes.txt @@ -0,0 +1 @@ +Subglottisches Karzinom[C32.2 ] \ No newline at end of file diff --git a/748/ops_codes.txt b/748/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..98992098273c82042cf2fa1c3244c8ee4e9c414c --- /dev/null +++ b/748/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Resektion an der Trachea mit Anlegen eines Tracheostomas[5-314.12 ] \ No newline at end of file diff --git a/748/patient_clinical_data.json b/748/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c727d364b20187bd10920086823ea594cc4b653a --- /dev/null +++ b/748/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 6, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/748/patient_pathological_data.json b/748/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a69787d4719ddcaa3ed4362df6ceb1c74e50e7da --- /dev/null +++ b/748/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "748", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/748/surgery_description.txt b/748/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0b5a0a28c5d71d3f8656328c4499ce630afe715b --- /dev/null +++ b/748/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy and Tracheotomy diff --git a/748/surgery_report.txt b/748/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..74a6e6e1f6517749f58585b4ef90d9907287d73a --- /dev/null +++ b/748/surgery_report.txt @@ -0,0 +1 @@ +First consultation with the anesthesia department. Then insertion of a feeding tube. Abjode and cover the operating area. Then application of local anesthesia in the area of the soft tissues of the neck. Now skin incision in the median line from the hyoid bone to the manubrium sterni. Dissection conditions significantly more difficult due to scarred adhesions. Exposure of the infrahyoid musculature. Exposure of the trachea Exposure of the thyroid gland, exposure of the isthmus of the thyroid gland. Dissection of the isthmus of the thyroid gland. Exposure of the anterior wall of the trachea. Cranial dissection and exposure of the laryngeal skeleton. Exposure of the thyroid cartilage and the cricoid cartilage. Exposure of the ligamentum conicum, exposure of the hyoid bone. In view of the previous operation, clear adhesions which make preparation difficult. Now expose the posterior edge of the thyroid cartilage. Remove the cornu majus of the thyroid cartilage on both sides. Cut the thyrohyoid ligament. In order to keep the pharyngeal defect as small as possible, the epiglottis is partially preserved. Expose supraglottically at the level of the upper edge of the thyroid cartilage. Careful preparation in the larynx and maximum preservation of the mucosa. Dissection along the aryepiglottic fold and exposure of the mucosa postcricoid. Careful preparation anteriorly while preserving the pharyngeal mucosa. Now estimate the distal extent of the tumor and carefully release the larynx. Deposition in the area of the second tracheal ring. As far as can be assessed intraoperatively, the resection here is in healthy tissue. Nevertheless, frozen sections are taken, which still show submucosal tumor growth in the area of the tracheal separation. As a result, two further tracheal clips are resected. The frozen section examination now shows a resection in sano. A mucosal sample in the supraglottic region also showed a resection in healthy tissue, so that an R0 resection can be assumed. Multi-layer closure of the pharyngeal defect. Irrigation of the wound with water and hydrogen. Mobilization of the trachea and suturing of the trachea. Wound closure in layers. Final consultation with the anesthesia department. Transfer of the patient to the intensive care unit. \ No newline at end of file diff --git a/749/InvasionFront_CD3_block8_x5_y1_patient749_0.json b/749/InvasionFront_CD3_block8_x5_y1_patient749_0.json new file mode 100644 index 0000000000000000000000000000000000000000..23e4e7fb4c6e36421a66e3798851c1701aebe94b --- /dev/null +++ b/749/InvasionFront_CD3_block8_x5_y1_patient749_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16116.5, + "Centroid Y µm": 12518.4, + "Num Detections": 16411, + "Num Negative": 14859, + "Num Positive": 1552, + "Positive %": 9.457, + "Num Positive per mm^2": 811.25 + } +} \ No newline at end of file diff --git a/749/InvasionFront_CD3_block8_x6_y1_patient749_1.json b/749/InvasionFront_CD3_block8_x6_y1_patient749_1.json new file mode 100644 index 0000000000000000000000000000000000000000..13fe3c228a157e0f7a6f4ae3c4b1c5c9b47c9dd4 --- /dev/null +++ b/749/InvasionFront_CD3_block8_x6_y1_patient749_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 12543.4, + "Num Detections": 23555, + "Num Negative": 21808, + "Num Positive": 1747, + "Positive %": 7.417, + "Num Positive per mm^2": 771.86 + } +} \ No newline at end of file diff --git a/749/InvasionFront_CD8_block8_x5_y1_patient749_0.json b/749/InvasionFront_CD8_block8_x5_y1_patient749_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9904170fb4ba9868211c0e7ab861f6837758b05d --- /dev/null +++ b/749/InvasionFront_CD8_block8_x5_y1_patient749_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17615.7, + "Centroid Y µm": 2798.5, + "Num Detections": 16967, + "Num Negative": 15089, + "Num Positive": 1878, + "Positive %": 11.07, + "Num Positive per mm^2": 966.8 + } +} \ No newline at end of file diff --git a/749/InvasionFront_CD8_block8_x6_y1_patient749_1.json b/749/InvasionFront_CD8_block8_x6_y1_patient749_1.json new file mode 100644 index 0000000000000000000000000000000000000000..005754fb9b68dd7eac35ab208a9796aa1d0151af --- /dev/null +++ b/749/InvasionFront_CD8_block8_x6_y1_patient749_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20064.4, + "Centroid Y µm": 2798.5, + "Num Detections": 23216, + "Num Negative": 21462, + "Num Positive": 1754, + "Positive %": 7.555, + "Num Positive per mm^2": 772.23 + } +} \ No newline at end of file diff --git a/749/TumorCenter_CD3_block8_x5_y1_patient749_0.json b/749/TumorCenter_CD3_block8_x5_y1_patient749_0.json new file mode 100644 index 0000000000000000000000000000000000000000..320ca8b9cf597c9f35cec86f251d864c370b01f2 --- /dev/null +++ b/749/TumorCenter_CD3_block8_x5_y1_patient749_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15167.0, + "Centroid Y µm": 2898.5, + "Num Detections": 24324, + "Num Negative": 23104, + "Num Positive": 1220, + "Positive %": 5.016, + "Num Positive per mm^2": 517.66 + } +} \ No newline at end of file diff --git a/749/TumorCenter_CD3_block8_x6_y1_patient749_1.json b/749/TumorCenter_CD3_block8_x6_y1_patient749_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c314a92c439201bfdc3fd3c6ade8c40318909949 --- /dev/null +++ b/749/TumorCenter_CD3_block8_x6_y1_patient749_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17640.7, + "Centroid Y µm": 2548.7, + "Num Detections": 21770, + "Num Negative": 20167, + "Num Positive": 1603, + "Positive %": 7.363, + "Num Positive per mm^2": 801.05 + } +} \ No newline at end of file diff --git a/749/TumorCenter_CD8_block8_x5_y1_patient749_0.json b/749/TumorCenter_CD8_block8_x5_y1_patient749_0.json new file mode 100644 index 0000000000000000000000000000000000000000..46b3635da28986c6026014df21066633cf2ec8d4 --- /dev/null +++ b/749/TumorCenter_CD8_block8_x5_y1_patient749_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15866.6, + "Centroid Y µm": 2773.5, + "Num Detections": 24652, + "Num Negative": 23575, + "Num Positive": 1077, + "Positive %": 4.369, + "Num Positive per mm^2": 515.88 + } +} \ No newline at end of file diff --git a/749/TumorCenter_CD8_block8_x6_y1_patient749_1.json b/749/TumorCenter_CD8_block8_x6_y1_patient749_1.json new file mode 100644 index 0000000000000000000000000000000000000000..39d574f6e7dc3121ae8e78164c0a4c2252d40c9a --- /dev/null +++ b/749/TumorCenter_CD8_block8_x6_y1_patient749_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 2648.6, + "Num Detections": 14867, + "Num Negative": 13711, + "Num Positive": 1156, + "Positive %": 7.776, + "Num Positive per mm^2": 1011.1 + } +} \ No newline at end of file diff --git a/749/history_text.txt b/749/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..33fb1fcbfba627d47fe0ad1b479f1d46e9b3ed6f --- /dev/null +++ b/749/history_text.txt @@ -0,0 +1 @@ +The patient had a post-operative tumor tonsillectomy on the right side using TORS and neck dissection on both sides <2013> for cT1 cN2b cN0 G3 tonsillar carcinoma on the right. The patient apparently went to normal ward 300 postoperatively. At 21.15 the nursing staff called the duty doctor and an emergency alarm was sounded. Immediate notification of the 2nd and 3rd service at 9.15 pm and anesthesia at 9.16 pm. Arrival on the ward at 9.15 p.m. and transfer of the patient to the treatment room. The patient is acutely dyspneic with increasing cyanosis. Breathing spontaneously, awake and panicked. Attempt at enoral inspection, no bleeding. The neck is massively swollen on both sides and livid. Immediate opening of the right cervical suture. Clear discharge of venous blood, no possibility of intubation, therefore an emergency coniotomy was performed at approx. 21.16. \ No newline at end of file diff --git a/749/icd_codes.txt b/749/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc81c95f0fd38379b0d8bb08810f7cbe9d58d17f --- /dev/null +++ b/749/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 ] Nävus der Brustwand[D22.5 ] Halslymphknotenmetastasen[C77.0 ] \ No newline at end of file diff --git a/749/ops_codes.txt b/749/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a9b8f8f5456b8809f9f8a1b5da1f0bf959512c4 --- /dev/null +++ b/749/ops_codes.txt @@ -0,0 +1 @@ +Schleimhaut[5-296.21 ] Tonsillektomie [ohne Adenotomie] mit Dissektionstechnik[5-281.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Naevusexzision und Wundverschluss Brustwand und Rücken[5-894.1a ] \ No newline at end of file diff --git a/749/patient_clinical_data.json b/749/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c00e36ead98b6f7b7b0f8315d9d39a87555677c2 --- /dev/null +++ b/749/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/749/patient_pathological_data.json b/749/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d3b2a098c30e8b853df1613d77b3bf460f451de1 --- /dev/null +++ b/749/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "749", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 78, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/749/surgery_description.txt b/749/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..68c4a4e522e97666c86a2d21b75477e8ed5ab5ee --- /dev/null +++ b/749/surgery_description.txt @@ -0,0 +1 @@ +Transoral robot-assisted resection, Neck dissection diff --git a/749/surgery_report.txt b/749/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..527166310fe8b7aadc97fcf5fa3aa93fa2b7cee4 --- /dev/null +++ b/749/surgery_report.txt @@ -0,0 +1 @@ +First, after induction of intubation anesthesia, panendoscopy and inspection of the tonsil tumor, which is located in the upper part of the tonsil and merges very slightly onto the anterior palatal arch. The FK mouth retractor is then inserted and the tumor region exposed. The robot is then docked. The tumor tonsillectomy is then performed with the robot, starting with a mucosal incision close to the uvula. With resection of the anterior palatal arch and partly the posterior palatal arch, dissection into the pharyngeal musculature. The dissection is then carried out in the area of the pharyngeal muscles from cranial to caudal. Dissection takes place in the area of the lower tonsil pole at the transition to the base of the tongue. In the area of the upper third of the tonsil, the tumor borders appear to extend close to the resection. The specimen is marked here with a thread. A generous resection is then made in this area. The other margins are well within the healthy tissue. Therefore, only a frozen section is taken in the area of the upper lateral pole after the resection. This specimen is found to be tumor-free intraoperatively. Therefore, an R0 resection can now be assumed. Subtle hemostasis again. If the wound is dry, remove all instruments. After repositioning the patient, neck dissection on both sides. Now continue the operation (neck dissection on both sides) by , alternating head positioning for neck dissection on the right. Infiltration with 10 ml xylocaine with added adrenaline in the area of the planned skin incision on the right after marking the landmarks in the typical manner. Abjode and sterile draping of the adjacent areas. Curved skin incision in the area of the anterior border of the sternocleidomastoid muscle. Separation of the skin and platysma, then exposure of the anterior edge of the sternocleidomastoid muscle. Dissection of the omohyoid muscle and exposure of the internal jugular vein. A macroscopically impressive lymph node metastasis measuring approx. 3 x 5 cm is located on the internal jugular vein. Then expose the accessorius nerve. Now locate the digastric muscle. After identification of all landmarks, insertion of the caudal and cranial retractors. Then dissect the internal jugular vein and expose the cervical vascular sheath with vagus nerve, internal jugular vein and facial vein as well as the common carotid artery. Protect the above-mentioned structures and clear out the entire posterior neck preparation while protecting the accessorius nerve and the entire cervical plexus. Now dissect anteriorly and expose the hypoglossal nerve, the capsule of the submandibular gland and complete the upper neck preparation. Hemostasis using Bipolar, resorption, no more evidence of bleeding, irrigation with Ringer. No more evidence of bleeding. Insertion of a 10-gauge Redon drain and two-layer wound closure. Transfer to neck dissection of the right side. Infiltration with 10 ml xylocaine with added adrenaline and another curved skin incision in the area of the anterior edge of the sternocleidomastoid muscle. Dissection of the platysma, exposure of the anterior edge of the sternocleidomastoid muscle. Then dissection of the landmarks, the omohyoid muscle and exploration of the internal jugular vein. Exposure of the accessorius nerve and finally the digastric muscle. Insertion of a retractor caudally and cranially and preparation on the anterior side of the internal jugular vein for the posterior neck preparation. Then expose the cervical vascular sheath with vagus nerve, internal jugular vein, facial vein and common carotid artery. The above-mentioned structures are spared. Tracing up to the cervical plexus. Further dissection of the accessorius nerve in a cranial direction and finally clearing out the posterior neck preparation while sparing the accessorius nerve and all plexus branches. Then dissection and exposure of the hypoglossal nerve and the capsule of the submandibular gland with completion of the anterior neck preparation. Finally, inspection without further sources of bleeding after hemostasis using bipolarization. Irrigation with Ringer. No further evidence of bleeding. Insertion of a 10-gauge Redon drain, then two-layer wound closure. The procedure was completed without complications. The right-sided lymph node metastasis could be easily dissected from the internal jugular vein without infiltration of the surrounding structures. On the left side, level II lymph nodes approx. 1-2 cm in size were present, which are contained in their entirety in the neck preparation. Conclusion: R0 resection of a cT1 cN2b tonsillar carcinoma on the right (transoral robot-assisted) and neck dissection on both sides Level IIa to V. Procedure: Tumor conference with question of adjuvant therapy. \ No newline at end of file diff --git a/750/InvasionFront_CD3_block17_x3_y7_patient750_0.json b/750/InvasionFront_CD3_block17_x3_y7_patient750_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9692c181381c79f82389628e6266909ce6b535ab --- /dev/null +++ b/750/InvasionFront_CD3_block17_x3_y7_patient750_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10894.2, + "Centroid Y µm": 22738.0, + "Num Detections": 23432, + "Num Negative": 21733, + "Num Positive": 1699, + "Positive %": 7.251, + "Num Positive per mm^2": 638.47 + } +} \ No newline at end of file diff --git a/750/InvasionFront_CD3_block17_x4_y7_patient750_1.json b/750/InvasionFront_CD3_block17_x4_y7_patient750_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8370a963631b4322b7a12a5a44889dc759ab7400 --- /dev/null +++ b/750/InvasionFront_CD3_block17_x4_y7_patient750_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 22738.0, + "Num Detections": 10128, + "Num Negative": 9538, + "Num Positive": 590, + "Positive %": 5.825, + "Num Positive per mm^2": 480.8 + } +} \ No newline at end of file diff --git a/750/InvasionFront_CD8_block17_x3_y7_patient750_0.json b/750/InvasionFront_CD8_block17_x3_y7_patient750_0.json new file mode 100644 index 0000000000000000000000000000000000000000..12d90b26aa36af0bea321a60d02768cd5b78d2cd --- /dev/null +++ b/750/InvasionFront_CD8_block17_x3_y7_patient750_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 17790.6, + "Num Detections": 24403, + "Num Negative": 23764, + "Num Positive": 639, + "Positive %": 2.619, + "Num Positive per mm^2": 240.5 + } +} \ No newline at end of file diff --git a/750/InvasionFront_CD8_block17_x4_y7_patient750_1.json b/750/InvasionFront_CD8_block17_x4_y7_patient750_1.json new file mode 100644 index 0000000000000000000000000000000000000000..81edb6625732492ba24e16327646512342713c63 --- /dev/null +++ b/750/InvasionFront_CD8_block17_x4_y7_patient750_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 17840.6, + "Num Detections": 12869, + "Num Negative": 12686, + "Num Positive": 183, + "Positive %": 1.422, + "Num Positive per mm^2": 131.2 + } +} \ No newline at end of file diff --git a/750/TumorCenter_CD3_block17_x3_y7_patient750_0.json b/750/TumorCenter_CD3_block17_x3_y7_patient750_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7f636ab98af45675a5486b4e2445710ba19953df --- /dev/null +++ b/750/TumorCenter_CD3_block17_x3_y7_patient750_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 17490.7, + "Num Detections": 20614, + "Num Negative": 19728, + "Num Positive": 886, + "Positive %": 4.298, + "Num Positive per mm^2": 405.74 + } +} \ No newline at end of file diff --git a/750/TumorCenter_CD3_block17_x4_y7_patient750_1.json b/750/TumorCenter_CD3_block17_x4_y7_patient750_1.json new file mode 100644 index 0000000000000000000000000000000000000000..009cfa97c7e12d986fa8189e200cb88fd1842555 --- /dev/null +++ b/750/TumorCenter_CD3_block17_x4_y7_patient750_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13342.9, + "Centroid Y µm": 17465.8, + "Num Detections": 13703, + "Num Negative": 12530, + "Num Positive": 1173, + "Positive %": 8.56, + "Num Positive per mm^2": 709.64 + } +} \ No newline at end of file diff --git a/750/TumorCenter_CD8_block17_x3_y7_patient750_0.json b/750/TumorCenter_CD8_block17_x3_y7_patient750_0.json new file mode 100644 index 0000000000000000000000000000000000000000..752ea50ec8fceee4f7b763683b0dd9cc3e10ff42 --- /dev/null +++ b/750/TumorCenter_CD8_block17_x3_y7_patient750_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 31283.4, + "Num Detections": 20748, + "Num Negative": 20450, + "Num Positive": 298, + "Positive %": 1.436, + "Num Positive per mm^2": 138.0 + } +} \ No newline at end of file diff --git a/750/TumorCenter_CD8_block17_x4_y7_patient750_1.json b/750/TumorCenter_CD8_block17_x4_y7_patient750_1.json new file mode 100644 index 0000000000000000000000000000000000000000..19a7da7c94c291ac5b56a517c7a13e5690397c77 --- /dev/null +++ b/750/TumorCenter_CD8_block17_x4_y7_patient750_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 31158.5, + "Num Detections": 12198, + "Num Negative": 11991, + "Num Positive": 207, + "Positive %": 1.697, + "Num Positive per mm^2": 138.0 + } +} \ No newline at end of file diff --git a/750/history_text.txt b/750/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/750/icd_codes.txt b/750/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b6f71cefce893af31fb2e9010361238fc037c164 --- /dev/null +++ b/750/icd_codes.txt @@ -0,0 +1 @@ +Stimmlippenkarzinom[C32.0 R] \ No newline at end of file diff --git a/750/ops_codes.txt b/750/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..84fd7f2efa734ae005f1de42a20a369a7396c426 --- /dev/null +++ b/750/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie endoskopische Laserresektion[5-302.5 ] \ No newline at end of file diff --git a/750/patient_clinical_data.json b/750/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d8ceb13955f6e6f6121ef7b271e7d3e821ba0711 --- /dev/null +++ b/750/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/750/patient_pathological_data.json b/750/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ce6e43badef2dbb5c877ead9be1a5f922198e157 --- /dev/null +++ b/750/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "750", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": 0.5 +} \ No newline at end of file diff --git a/750/surgery_description.txt b/750/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..63608901e9c5ed652e6b0e2e0b5e636a15861baa --- /dev/null +++ b/750/surgery_description.txt @@ -0,0 +1 @@ +Laser surgical transoral right chordectomy diff --git a/750/surgery_report.txt b/750/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0119e3872ba1dcd9159631c3cfd7b36cedfacae1 --- /dev/null +++ b/750/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first set the endolarynx with the JA tube under the protection of the edentulous maxilla. Here you can see the slightly thickened right vocal fold, which has two whitish overlays, with the whitish overlay extending dorsally to the vocal process. Even with external pressure, the glottis on the right side is not completely visible laterally, but is covered by the supraglottis. For this reason, a strip of tissue is first resected from the supraglottis. The right vocal fold is then fully visible. It can now be seen that the changes in the vocal folds do not extend into the anterior commissure. The tumor also does not extend very far laterally on palpation. Start with laser surgical chordectomy with the CO2 laser ventrally. Here, the vocal fold is resected at a sufficient microscopic safety distance. Laterally, parts of the vocalis muscle are included in the resection. The resection extends posteriorly to the arytenoid cartilage, which is exposed at the vocal process, whereby the last section of the mucosa appears inconspicuous here. The resection is then guided caudally over the subglottic slope under visualization so that the entire resectate can then be removed in toto. Suture marking on the ventral resection margin. The resection margins are then resected with cold instruments and the removed tissue is sent as a resected specimen for frozen section histology. These are all found to be tumor-free. Careful hemostasis is then performed. After receiving the frozen section histology diagnosis, the patient was extubated without any problems and handed over to the anesthesia department. Conclusion: Transoral laser surgical chordectomy on the right side for cT1a glottic laryngeal carcinoma. As part of the tumor follow-up, a 1st control panendoscopy is recommended after 10-12 weeks \ No newline at end of file diff --git a/751/InvasionFront_CD3_block10_x3_y6_patient751_0.json b/751/InvasionFront_CD3_block10_x3_y6_patient751_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e3cb5de360d9fc7ba25b66d8266eda68de8fb75c --- /dev/null +++ b/751/InvasionFront_CD3_block10_x3_y6_patient751_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12843.2, + "Centroid Y µm": 20564.1, + "Num Detections": 13001, + "Num Negative": 11349, + "Num Positive": 1652, + "Positive %": 12.71, + "Num Positive per mm^2": 965.16 + } +} \ No newline at end of file diff --git a/751/InvasionFront_CD3_block10_x4_y6_patient751_1.json b/751/InvasionFront_CD3_block10_x4_y6_patient751_1.json new file mode 100644 index 0000000000000000000000000000000000000000..67fd3dbb9529c20b1e353702f3d0e67015501393 --- /dev/null +++ b/751/InvasionFront_CD3_block10_x4_y6_patient751_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 20614.1, + "Num Detections": 17478, + "Num Negative": 16211, + "Num Positive": 1267, + "Positive %": 7.249, + "Num Positive per mm^2": 537.0 + } +} \ No newline at end of file diff --git a/751/InvasionFront_CD8_block10_x3_y6_patient751_0.json b/751/InvasionFront_CD8_block10_x3_y6_patient751_0.json new file mode 100644 index 0000000000000000000000000000000000000000..93a7345f66bd6ec7892b7d0633f8f91497c37d46 --- /dev/null +++ b/751/InvasionFront_CD8_block10_x3_y6_patient751_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12193.5, + "Centroid Y µm": 20814.0, + "Num Detections": 13777, + "Num Negative": 12163, + "Num Positive": 1614, + "Positive %": 11.72, + "Num Positive per mm^2": 889.97 + } +} \ No newline at end of file diff --git a/751/InvasionFront_CD8_block10_x4_y6_patient751_1.json b/751/InvasionFront_CD8_block10_x4_y6_patient751_1.json new file mode 100644 index 0000000000000000000000000000000000000000..016d34096a0f09fe8ebe048748e39bf7ffaffea4 --- /dev/null +++ b/751/InvasionFront_CD8_block10_x4_y6_patient751_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15291.9, + "Centroid Y µm": 20764.0, + "Num Detections": 18388, + "Num Negative": 17383, + "Num Positive": 1005, + "Positive %": 5.466, + "Num Positive per mm^2": 419.78 + } +} \ No newline at end of file diff --git a/751/TumorCenter_CD3_block10_x3_y6_patient751_0.json b/751/TumorCenter_CD3_block10_x3_y6_patient751_0.json new file mode 100644 index 0000000000000000000000000000000000000000..04b6ea60324f8272a6f255f27d1365e3bfdfee98 --- /dev/null +++ b/751/TumorCenter_CD3_block10_x3_y6_patient751_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 14717.2, + "Num Detections": 15033, + "Num Negative": 14336, + "Num Positive": 697, + "Positive %": 4.636, + "Num Positive per mm^2": 328.54 + } +} \ No newline at end of file diff --git a/751/TumorCenter_CD3_block10_x4_y6_patient751_1.json b/751/TumorCenter_CD3_block10_x4_y6_patient751_1.json new file mode 100644 index 0000000000000000000000000000000000000000..59ea2ac73e70aaa39e51dc3a956e0e8b8a771b8d --- /dev/null +++ b/751/TumorCenter_CD3_block10_x4_y6_patient751_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 14767.2, + "Num Detections": 12886, + "Num Negative": 10780, + "Num Positive": 2106, + "Positive %": 16.34, + "Num Positive per mm^2": 1245.7 + } +} \ No newline at end of file diff --git a/751/TumorCenter_CD8_block10_x3_y6_patient751_0.json b/751/TumorCenter_CD8_block10_x3_y6_patient751_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9a7bfed9691daca6632233c3e0354dabd868e0d4 --- /dev/null +++ b/751/TumorCenter_CD8_block10_x3_y6_patient751_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 15491.8, + "Num Detections": 16495, + "Num Negative": 14875, + "Num Positive": 1620, + "Positive %": 9.821, + "Num Positive per mm^2": 736.69 + } +} \ No newline at end of file diff --git a/751/TumorCenter_CD8_block10_x4_y6_patient751_1.json b/751/TumorCenter_CD8_block10_x4_y6_patient751_1.json new file mode 100644 index 0000000000000000000000000000000000000000..85885cae7cd4aa7fad5b56bc2e53e035de1a38e0 --- /dev/null +++ b/751/TumorCenter_CD8_block10_x4_y6_patient751_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 15416.8, + "Num Detections": 15151, + "Num Negative": 9400, + "Num Positive": 5751, + "Positive %": 37.96, + "Num Positive per mm^2": 3030.6 + } +} \ No newline at end of file diff --git a/751/history_text.txt b/751/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..39dc3d2a05abc947ea234de523097b191ef970c4 --- /dev/null +++ b/751/history_text.txt @@ -0,0 +1 @@ +Mrs. presented to our outpatient clinic with an externally histologically confirmed tonsillar carcinoma on the left side and a cervical mass that was progressing in size. Mild dysphagia for 4 to 5 weeks without further complaints. With histologically confirmed carcinoma, indication for tumor resection and panendoscopy to exclude a second malignancy. \ No newline at end of file diff --git a/751/icd_codes.txt b/751/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..187a780dea8b6dfbfe5590d15406c107a759292c --- /dev/null +++ b/751/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Tonsille mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/751/ops_codes.txt b/751/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cbf55f3d81fdf69f8860bcfc9d73c617c4495c64 --- /dev/null +++ b/751/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/751/patient_clinical_data.json b/751/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b768ae5c94bc20cbce2dda88be86279c540ae60b --- /dev/null +++ b/751/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 59, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/751/patient_pathological_data.json b/751/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d0f2d0066d5fa6d30b8f6206212facaab1c2fc23 --- /dev/null +++ b/751/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "751", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 53, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/751/surgery_description.txt b/751/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b453f4540c05920bbb0584a9150b61ec7976ce68 --- /dev/null +++ b/751/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy with Panendoscopy diff --git a/751/surgery_report.txt b/751/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9583d2a4645bfe0eece3659326343d0d55a7b883 --- /dev/null +++ b/751/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues and intubation of the patient after tracheoscopy by the surgeon. First rigid laryngo/pharyngo/hypopharyngoscopy and inspection of the oral cavity. Right and left piriform sinuses are unremarkable. The trachea, glottis and supraglottis are also unremarkable. Inspection of the oral cavity and palpation. The base of the tongue is unremarkable on palpation and inspection. Localization of the tumor described above. Extension caudal to the lower tonsillar pole without transition to the mandible, cranial to the upper tonsillar pole to the parauvular left, lateral and basal palpation shows a slight infiltration of the neck muscles. Insertion of the McIvor oral spatula and addition of . Mucosal marking and incision with the electric needle of the entire tumor resectate. Locate the tonsil and tumor capsule and further dissect laterally, taking healthy tissue and muscles with you. Further dissection of the tonsil and removal of the lower tonsil pole after bipolar coagulation with a macroscopic safety margin of approx. 7 mm. Now further dissection latero-medially and careful placement of the tonsil at the upper pole after bipolar coagulation parauvularly. Here the narrowest point is macroscopically visible with a distance of 3 to 4 mm. After removal of the tonsil, large wound bed with partially exposed fat anterior laterally. Marginal samples were now taken from laterally from the posterior palatal arch basally, caudally and cranially. The last marginal sample was taken parauvularly, where the resection has the smallest safety margin. Subsequently, hemostasis was performed again. Now turn to flexible esophagogastroscopy. Careful advancement under constant air insufflation into the stomach. No tumor or other suspicious change was found. After partial gastric resection, a very small residual stomach was found in terms of volume. After consulting and in the case of an unclear diaphanoscopy, a PEG was deliberately omitted. According to , a PEG or PEJ insertion must be carried out after internal assessment. Here insertion of a nasogastric tube. The patient must remain fasting for 5 days. Termination of the procedure. Conclusion: Enoral tonsil tumor resection for cT1-2 cN2c tonsillar carcinoma of the left side. If partial gastric resection has been performed and diaphanoscopy is unclear, PEG placement is dispensed with. PEG or PEJ placement after internal assessment. The resection was performed macroscopically in healthy tissue. In the case of R0 resection, a neck dissection should be planned on both sides, possibly with a tracheostomy. In an R1 situation, the resection must be planned immediately with flap coverage. \ No newline at end of file diff --git a/752/InvasionFront_CD3_block20_x1_y12_patient752_0.json b/752/InvasionFront_CD3_block20_x1_y12_patient752_0.json new file mode 100644 index 0000000000000000000000000000000000000000..97083a68020a28e5d68cb7cbea2b3ee389b26731 --- /dev/null +++ b/752/InvasionFront_CD3_block20_x1_y12_patient752_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3598.1, + "Centroid Y µm": 28509.9, + "Num Detections": 14827, + "Num Negative": 14262, + "Num Positive": 565, + "Positive %": 3.811, + "Num Positive per mm^2": 293.11 + } +} \ No newline at end of file diff --git a/752/InvasionFront_CD3_block20_x2_y12_patient752_1.json b/752/InvasionFront_CD3_block20_x2_y12_patient752_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a06b4bb00b4bff35405e03b34e294de59896571 --- /dev/null +++ b/752/InvasionFront_CD3_block20_x2_y12_patient752_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 28909.7, + "Num Detections": 16594, + "Num Negative": 16093, + "Num Positive": 501, + "Positive %": 3.019, + "Num Positive per mm^2": 245.29 + } +} \ No newline at end of file diff --git a/752/InvasionFront_CD8_block20_x1_y11_patient752_0.json b/752/InvasionFront_CD8_block20_x1_y11_patient752_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bcf3161d42c24ccd4687cbeaed065d8ed2802caa --- /dev/null +++ b/752/InvasionFront_CD8_block20_x1_y11_patient752_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5122.3, + "Centroid Y µm": 27635.4, + "Num Detections": 18776, + "Num Negative": 17449, + "Num Positive": 1327, + "Positive %": 7.068, + "Num Positive per mm^2": 688.18 + } +} \ No newline at end of file diff --git a/752/InvasionFront_CD8_block20_x2_y11_patient752_1.json b/752/InvasionFront_CD8_block20_x2_y11_patient752_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2fed4bcea523611550adc55f91b12f008a627bad --- /dev/null +++ b/752/InvasionFront_CD8_block20_x2_y11_patient752_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7646.0, + "Centroid Y µm": 27535.4, + "Num Detections": 24446, + "Num Negative": 16913, + "Num Positive": 7533, + "Positive %": 30.81, + "Num Positive per mm^2": 2947.3 + } +} \ No newline at end of file diff --git a/752/TumorCenter_CD3_block20_x1_y11_patient752_0.json b/752/TumorCenter_CD3_block20_x1_y11_patient752_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e35a444714fd554b0fc68585f06cd4d70df95603 --- /dev/null +++ b/752/TumorCenter_CD3_block20_x1_y11_patient752_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3752.5, + "Centroid Y µm": 26623.1, + "Num Detections": 14706, + "Num Negative": 11364, + "Num Positive": 3342, + "Positive %": 22.73, + "Num Positive per mm^2": 1495.4 + } +} \ No newline at end of file diff --git a/752/TumorCenter_CD3_block20_x2_y11_patient752_1.json b/752/TumorCenter_CD3_block20_x2_y11_patient752_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b61b3a49805e314374757a6f3a67d675dec6d96b --- /dev/null +++ b/752/TumorCenter_CD3_block20_x2_y11_patient752_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6335.3, + "Centroid Y µm": 26588.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/752/TumorCenter_CD8_block20_x1_y11_patient752_0.json b/752/TumorCenter_CD8_block20_x1_y11_patient752_0.json new file mode 100644 index 0000000000000000000000000000000000000000..deef2cc6c28221f2377caa35a7d78b08dee7f28a --- /dev/null +++ b/752/TumorCenter_CD8_block20_x1_y11_patient752_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4122.8, + "Centroid Y µm": 27960.2, + "Num Detections": 21311, + "Num Negative": 17958, + "Num Positive": 3353, + "Positive %": 15.73, + "Num Positive per mm^2": 1436.8 + } +} \ No newline at end of file diff --git a/752/TumorCenter_CD8_block20_x2_y11_patient752_1.json b/752/TumorCenter_CD8_block20_x2_y11_patient752_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fa3741d8b12d832b14158b88ee664c3ba5bdae65 --- /dev/null +++ b/752/TumorCenter_CD8_block20_x2_y11_patient752_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 27835.3, + "Num Detections": 21265, + "Num Negative": 19257, + "Num Positive": 2008, + "Positive %": 9.443, + "Num Positive per mm^2": 892.56 + } +} \ No newline at end of file diff --git a/752/history_text.txt b/752/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7c0b13bf8792a85876c565e3fb79a6a1f738e0ae --- /dev/null +++ b/752/history_text.txt @@ -0,0 +1 @@ +The patient was diagnosed with squamous cell carcinoma of the right vocal fold during a panendoscopy with microlaryngoscopy <2013>. In addition, the rhinoscopy revealed a large polyp in the area of the left middle nasal passage. A CT scan showed a shadow in the area of the ethmoid bone on the left and also on the right. As the patient was symptom-free with regard to the nose, the decision was made to perform a circumscribed, findings-adapted sinus operation on the left with polypectomy and laser chordectomy on the right in the case of histologically confirmed carcinoma. \ No newline at end of file diff --git a/752/icd_codes.txt b/752/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..46d73b7b0db755381fba01b4b4063b03a77cf029 --- /dev/null +++ b/752/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Polyposis nasi et sinuum[J33.8 ] \ No newline at end of file diff --git a/752/ops_codes.txt b/752/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cdf790d645eb83e076fd3cde9b7efc5e1b18443e --- /dev/null +++ b/752/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] Exzision erkranktes Gewebe Larynx mikrolaryngoskopisch[5-300.2 ] Endonasale Ethmoidektomie ohne Darstellung der Schädelbasis[5-222.20 L] Fensterung Kieferhöhle über mittleren Nasengang[5-221.1 L] \ No newline at end of file diff --git a/752/patient_clinical_data.json b/752/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..72cd689af93c604dbf2ad7c5624b314ce51bdce2 --- /dev/null +++ b/752/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/752/patient_pathological_data.json b/752/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7091cd2a8a931a9ca90949d49dbfafcb95ee1beb --- /dev/null +++ b/752/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "752", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/752/surgery_report.txt b/752/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..240ad9ff3a27fc8bb175d03a798b89938e85adc7 --- /dev/null +++ b/752/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, the surgeon first positions the patient. Shortening of the vibrissae, disinfection of the vestibule. Sterile wiping and draping. Entering the left nasal cavity with 45° optics. The large polyp is already visible. This is grasped at the base and successively removed. The anterior ethmoid bone is opened and the ethmoid bone is cleared out in a circumscribed manner. The base of the skull is not exposed. Subsequently, careful infundibulotomy on the left and exposure of the maxillary sinus ostium. This is carefully widened with the wing punches and smoothed in the area of the ethmoidal sinus transition with the cutting Blakesley. The maxillary sinus itself is free and without irritation. Therefore, no further measures should be taken in this area for the time being. Reposition the patient. Enter with the small irrigation tube and adjust the endolarynx. The exophytic mass described above can already be seen in the area of the right vocal fold, which extends to the anterior commissure but does not appear to infiltrate it. Laterally, it appears to extend partially into the ventriculus laryngis. Dorsally, the mass extends as far as the vocal process. Therefore, first carefully cut around the tumor with macroscopically sufficient safety distance using the laser with 4 watts in CW mode. This works very well. Successive dissection and removal of the tumor. The vocalis muscle is largely resected as well as parts of the pocket fold. As the tumor reaches the vocal process, this is also resected with the laser. Ultimately, the tumor is successfully resected in toto with a macroscopically sufficient safety margin. In between, hemostasis is repeatedly performed with a defocused laser and supratupers. Finally, marginal samples are taken in the area of the posterior pocket fold, anterior pocket fold, anterior commissure, subglottic anterior, subglottic posterior and in the area of the arytenoid cartilage. These marginal samples were all found to be tumor-free in the frozen section. An R0 resection can therefore be assumed. The procedure was completed without complications. Conclusion: Overall findings-adapted paranasal sinus surgery with polypectomy. R0 resection of a pT1a vocal fold carcinoma on the right in the frozen section. A control microlaryngoscopy should be performed in 4 to 6 weeks. Depending on the patient's symptoms, sinus surgery should be discussed at intervals. \ No newline at end of file diff --git a/753/InvasionFront_CD3_block10_x5_y3_patient753_0.json b/753/InvasionFront_CD3_block10_x5_y3_patient753_0.json new file mode 100644 index 0000000000000000000000000000000000000000..970bd50d317776bb13157e3983d2845e5d5eaa8a --- /dev/null +++ b/753/InvasionFront_CD3_block10_x5_y3_patient753_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19102.4, + "Centroid Y µm": 13130.5, + "Num Detections": 15864, + "Num Negative": 15293, + "Num Positive": 571, + "Positive %": 3.599, + "Num Positive per mm^2": 337.55 + } +} \ No newline at end of file diff --git a/753/InvasionFront_CD3_block10_x6_y3_patient753_1.json b/753/InvasionFront_CD3_block10_x6_y3_patient753_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f6348d8d61a9880a224370e61af4c751ae2c5eb8 --- /dev/null +++ b/753/InvasionFront_CD3_block10_x6_y3_patient753_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21663.5, + "Centroid Y µm": 13280.5, + "Num Detections": 18217, + "Num Negative": 16432, + "Num Positive": 1785, + "Positive %": 9.799, + "Num Positive per mm^2": 857.82 + } +} \ No newline at end of file diff --git a/753/InvasionFront_CD8_block10_x5_y3_patient753_0.json b/753/InvasionFront_CD8_block10_x5_y3_patient753_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dba96adfef7e474eef57c4a770af308544eabd07 --- /dev/null +++ b/753/InvasionFront_CD8_block10_x5_y3_patient753_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18102.9, + "Centroid Y µm": 13118.1, + "Num Detections": 16302, + "Num Negative": 15963, + "Num Positive": 339, + "Positive %": 2.079, + "Num Positive per mm^2": 191.95 + } +} \ No newline at end of file diff --git a/753/InvasionFront_CD8_block10_x6_y3_patient753_1.json b/753/InvasionFront_CD8_block10_x6_y3_patient753_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3278c8734ddf0586a06a05e2ba05e82d4ca6c28 --- /dev/null +++ b/753/InvasionFront_CD8_block10_x6_y3_patient753_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20726.5, + "Centroid Y µm": 13293.0, + "Num Detections": 20124, + "Num Negative": 18225, + "Num Positive": 1899, + "Positive %": 9.436, + "Num Positive per mm^2": 898.42 + } +} \ No newline at end of file diff --git a/753/TumorCenter_CD3_block10_x5_y3_patient753_0.json b/753/TumorCenter_CD3_block10_x5_y3_patient753_0.json new file mode 100644 index 0000000000000000000000000000000000000000..90bb6055bfee3cbfbb6ba316c1affcbe99025ae4 --- /dev/null +++ b/753/TumorCenter_CD3_block10_x5_y3_patient753_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 7171.2, + "Num Detections": 25016, + "Num Negative": 24226, + "Num Positive": 790, + "Positive %": 3.158, + "Num Positive per mm^2": 302.0 + } +} \ No newline at end of file diff --git a/753/TumorCenter_CD3_block10_x6_y3_patient753_1.json b/753/TumorCenter_CD3_block10_x6_y3_patient753_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c0ae5057ff5573418f2389d36e1a0b5dc4567d22 --- /dev/null +++ b/753/TumorCenter_CD3_block10_x6_y3_patient753_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21438.6, + "Centroid Y µm": 7071.3, + "Num Detections": 23089, + "Num Negative": 22363, + "Num Positive": 726, + "Positive %": 3.144, + "Num Positive per mm^2": 290.62 + } +} \ No newline at end of file diff --git a/753/TumorCenter_CD8_block10_x5_y3_patient753_0.json b/753/TumorCenter_CD8_block10_x5_y3_patient753_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0dbd71ee7c6072f6fafb07018a1e292d5ea0f669 --- /dev/null +++ b/753/TumorCenter_CD8_block10_x5_y3_patient753_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 7670.9, + "Num Detections": 26231, + "Num Negative": 25144, + "Num Positive": 1087, + "Positive %": 4.144, + "Num Positive per mm^2": 414.82 + } +} \ No newline at end of file diff --git a/753/icd_codes.txt b/753/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/753/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/753/patient_clinical_data.json b/753/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e653df2a6a7d3ad1adfc9d919dfb9d71771465d4 --- /dev/null +++ b/753/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/754/InvasionFront_CD3_block22_x3_y10_patient754_0.json b/754/InvasionFront_CD3_block22_x3_y10_patient754_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a4eb9904ef2bd94ec6b6a279e560612ec71ad2f6 --- /dev/null +++ b/754/InvasionFront_CD3_block22_x3_y10_patient754_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 36730.6, + "Num Detections": 23962, + "Num Negative": 19478, + "Num Positive": 4484, + "Positive %": 18.71, + "Num Positive per mm^2": 1738.3 + } +} \ No newline at end of file diff --git a/754/TumorCenter_CD3_block22_x3_y10_patient754_0.json b/754/TumorCenter_CD3_block22_x3_y10_patient754_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5c200860edaae823762348afe4d08875613f746a --- /dev/null +++ b/754/TumorCenter_CD3_block22_x3_y10_patient754_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10769.3, + "Centroid Y µm": 25561.5, + "Num Detections": 15180, + "Num Negative": 13150, + "Num Positive": 2030, + "Positive %": 13.37, + "Num Positive per mm^2": 967.27 + } +} \ No newline at end of file diff --git a/754/TumorCenter_CD8_block22_x3_y10_patient754_0.json b/754/TumorCenter_CD8_block22_x3_y10_patient754_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8027728c4638099ce9d5892ba3a3d1d4df3ac352 --- /dev/null +++ b/754/TumorCenter_CD8_block22_x3_y10_patient754_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12860.8, + "Centroid Y µm": 35397.3, + "Num Detections": 15196, + "Num Negative": 13626, + "Num Positive": 1570, + "Positive %": 10.33, + "Num Positive per mm^2": 721.22 + } +} \ No newline at end of file