diff --git a/509/InvasionFront_CD8_block11_x6_y9_patient509_1.json b/509/InvasionFront_CD8_block11_x6_y9_patient509_1.json new file mode 100644 index 0000000000000000000000000000000000000000..888b92416682a0e4c5c32833a791b14f839fb808 --- /dev/null +++ b/509/InvasionFront_CD8_block11_x6_y9_patient509_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21036.3, + "Centroid Y µm": 32842.3, + "Num Detections": 20699, + "Num Negative": 18365, + "Num Positive": 2334, + "Positive %": 11.28, + "Num Positive per mm^2": 1074.0 + } +} \ No newline at end of file diff --git a/509/TumorCenter_CD3_block11_x5_y9_patient509_0.json b/509/TumorCenter_CD3_block11_x5_y9_patient509_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f507e4d4054d7376159492024ae1e474d5a13735 --- /dev/null +++ b/509/TumorCenter_CD3_block11_x5_y9_patient509_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18851.0, + "Centroid Y µm": 22485.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/509/TumorCenter_CD8_block11_x5_y9_patient509_0.json b/509/TumorCenter_CD8_block11_x5_y9_patient509_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fc35632a0efbc795f3c6ad0e34b52571ab77f3c5 --- /dev/null +++ b/509/TumorCenter_CD8_block11_x5_y9_patient509_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16478.8, + "Centroid Y µm": 22225.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/509/TumorCenter_CD8_block11_x6_y9_patient509_1.json b/509/TumorCenter_CD8_block11_x6_y9_patient509_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d80e2f5b65ec0298b9a41350ffc0eded063003ce --- /dev/null +++ b/509/TumorCenter_CD8_block11_x6_y9_patient509_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18927.5, + "Centroid Y µm": 22325.7, + "Num Detections": 15635, + "Num Negative": 12625, + "Num Positive": 3010, + "Positive %": 19.25, + "Num Positive per mm^2": 1486.4 + } +} \ No newline at end of file diff --git a/509/history_text.txt b/509/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/509/icd_codes.txt b/509/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/509/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/509/ops_codes.txt b/509/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..98d549e8de771a74c04dd3c02e12bfb8415c4fa2 --- /dev/null +++ b/509/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Transplantat[5-296.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Perkutane [endoskopische] Gastrostomie [PEG][5-431.2 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] \ No newline at end of file diff --git a/509/patient_clinical_data.json b/509/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c0cc1ef3a27d763a3e8c401e69949aeb1dada573 --- /dev/null +++ b/509/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/509/patient_pathological_data.json b/509/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fad6a9b14862d5c16f68828a3fa08b0ca966f503 --- /dev/null +++ b/509/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "509", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/509/surgery_description.txt b/509/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..df0de155e370a11b462a250cfad8fa6f02487a63 --- /dev/null +++ b/509/surgery_description.txt @@ -0,0 +1 @@ +Kombiniert transoral transzervikale En-bloc-Resektion, Freier Lappen (Radialis) diff --git a/509/surgery_report.txt b/509/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..acb25ec8fe84c3afde7c7b4f7551e9aad7505b0c --- /dev/null +++ b/509/surgery_report.txt @@ -0,0 +1 @@ +First deepening of the anesthesia. After intubation through the anesthesia, pharyngoscopy and confirmation of an oropharyngeal carcinoma measuring at least cT2 on the left side, which just reaches the posterior wall of the oropharynx and extends caudally and medially into the base of the tongue. On palpation, the tumor is slightly larger in comparison with the computer tomography and is difficult to move laterally. Initially under strict diaphanoscopic control and after administration of 3 g Unacid, after skin disinfection and abjodation, placement of a 15 Charričre PEG tube using the thread pull-through technique. Strict diaphanoscopic conditions on all sides. The gastric mucosa is unremarkable. Sterile dressing. Then insertion of the tonsil plug. Inspection of the tumor tissue again. Then, using the electric needle of the bipolar forceps under visualization, start resection of the tumour from cranial to caudal, taking parts of the base of the tongue with it. The tumor is not visible at any time and is released at a wide macroscopic distance. However, it becomes apparent that the tumor has grown laterally into the pterygoid musculature and the palpatory distance of the lateral tumor border lies in depth up to the immediate vicinity of the carotid flow area. It was therefore decided to continue the tumor resection transcervically; 2 cranial margin samples were tumor-free. Skin disinfection and infiltration anesthesia with a total of 18 ml Ultracaine with added adrenaline on both cervical and median sides. Start with neck dissection on the left side: skin incision on the anterior edge of the sternocleidomastoid. Dissection of a subplatysmal portion of connective tissue. Release of the connective tissue sheath ventrally. Identification of the internal jugular vein, the omohyoid muscle and the digastric muscle. Remove the entire soft tissue mantle from the medial neck preparation, identify the superior thyroid artery and the hypoglossal nerve. Now release from caudal to cranial. Dissection of the internal jugular vein, the vagus nerve and the cervical nerve. Level III and II show large, conglomerate-like lymph node metastases through which the accessorius nerve runs. It was therefore decided to resect the nerve. The internal jugular vein, which also runs through the metastasis, is then removed together with the metastatic conglomerate. The external jugular vein is preserved. After releasing and removing the submandibular gland, access is gained through level I b into the oropharynx. The en bloc resection of the tumor is now completed. Basally in the wound area to the lateral side, the pathology still describes an R1 situation, which is why selective resection is performed again at this point; the other marginal samples were tumor-free. Dissection of the external and internal carotid artery. Ligation of the left lingual artery. Identification of the vascular nerve bundle of the superior pharyngeal artery. Subtle hemostasis and neck dissection on the right side: Here too, 2 to 3 oval lymph nodes are visible in levels II and III, but overall they are also to be classified as suspicious. Neck dissection levels I b, II, III and IV and partial V are now performed. The submandibular gland is preserved, as are the external jugular vein, vagus nerve, cervical nerve, accessorius and hypoglossus. The internal jugular vein is also preserved on this side; the submandibular gland, removal of 2 inconspicuous lymph nodes from level I b. After a door-like incision, cut the cutaneous and subcutaneous tissue to create a plastic tracheotomy. Blunt separation of the infrahyoid musculature. Identification of the anterior tracheal surface after transection of the isthmus of the thyroid gland. Visualization of the anterior surface of the trachea caudally. Incision between the 2nd and 3rd tracheal clasp area. Formation of a Björk flap. Re-intubation. After ethibond suture fixation at 6 points on a 9 mm Rügheimer cannula and problem-free ventilation. Suture fixation of the cannula edges with an Ethibond suture. Then removal of an area of inguinal skin measuring 12 x 6 cm and placement of a Redon drain. At the same time, the radial flap on the left side of the forearm is removed. After placing the tourniquet, the oropharyngeal defect region is marked. This is now adapted to the forearm. Skin incision, cut in an S-shape, from the crook of the elbow into the flap area. Starting radially, detachment of the myofascial tissue portion, release of the flap with identification of the antebrachial cutaneous nerve and the parallel vein. Identification of the radial artery-venous bundle and consecutive release from distal to proximal with multiple clip ligation and bipolar coagulation of the draining and feeding branches. It is thus possible to develop a wide stalk which, however, consists of 2 small caliber veins. Removal of the tourniquet and further hemostasis and preparation of the left cervical vascular area. Removal of the pedicle and primary closure of the defect with the inguinally removed full-thickness skin and application of a VAC dressing. Please leave this in place for 7 days. Suture removal on the 7th day. Please take photo documentation, several times intraoperatively. Then also dissect the stalk of the arterio-venous vascular bundle. Now primary suture of the artery or connection to the superior thyroid artery using 8.0 Ethilon. After dissection, the external jugular vein is first recruited and supplied with a 2.0 mm coupler. The second vein is supplied with a 1.0 coupler from a venous vessel in the area of the superior or middle thyroid vein. Overall, this is very difficult to achieve, but a dense vascular anastomosis is created in both the arterial and venous areas. After placement of a Redon drain on both cervical sides, the wound is closed in two layers and a dressing is applied. Discrete signs of congestion enorally at the end of the operation but good perfusion. Cannula change on day 3 to 5; suture removal on the neck on day 7. \ No newline at end of file diff --git a/510/InvasionFront_CD3_block9_x5_y9_patient510_0.json b/510/InvasionFront_CD3_block9_x5_y9_patient510_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6052065ee28c0ffa30a314a3fa62509ffe7de664 --- /dev/null +++ b/510/InvasionFront_CD3_block9_x5_y9_patient510_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17066.0, + "Centroid Y µm": 23662.5, + "Num Detections": 21810, + "Num Negative": 21013, + "Num Positive": 797, + "Positive %": 3.654, + "Num Positive per mm^2": 323.22 + } +} \ No newline at end of file diff --git a/510/InvasionFront_CD3_block9_x6_y9_patient510_1.json b/510/InvasionFront_CD3_block9_x6_y9_patient510_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6a5f2a48f11a6d05ed51edd7e0539a0ba8013a75 --- /dev/null +++ b/510/InvasionFront_CD3_block9_x6_y9_patient510_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19814.5, + "Centroid Y µm": 23937.3, + "Num Detections": 22698, + "Num Negative": 22233, + "Num Positive": 465, + "Positive %": 2.049, + "Num Positive per mm^2": 191.05 + } +} \ No newline at end of file diff --git a/510/InvasionFront_CD8_block9_x5_y9_patient510_0.json b/510/InvasionFront_CD8_block9_x5_y9_patient510_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a01957d48383777ac9abd6e17917ad95e4210e31 --- /dev/null +++ b/510/InvasionFront_CD8_block9_x5_y9_patient510_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17165.9, + "Centroid Y µm": 27185.6, + "Num Detections": 22706, + "Num Negative": 21369, + "Num Positive": 1337, + "Positive %": 5.888, + "Num Positive per mm^2": 549.67 + } +} \ No newline at end of file diff --git a/510/InvasionFront_CD8_block9_x6_y9_patient510_1.json b/510/InvasionFront_CD8_block9_x6_y9_patient510_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4ca565e0f006913d3db9fb3d654c3f9d13bcdd11 --- /dev/null +++ b/510/InvasionFront_CD8_block9_x6_y9_patient510_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19814.5, + "Centroid Y µm": 27360.5, + "Num Detections": 22930, + "Num Negative": 22413, + "Num Positive": 517, + "Positive %": 2.255, + "Num Positive per mm^2": 219.89 + } +} \ No newline at end of file diff --git a/510/TumorCenter_CD3_block9_x5_y9_patient510_0.json b/510/TumorCenter_CD3_block9_x5_y9_patient510_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b8ab681efec594731aa4b41730b82966c2369637 --- /dev/null +++ b/510/TumorCenter_CD3_block9_x5_y9_patient510_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 28260.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/510/TumorCenter_CD3_block9_x6_y9_patient510_1.json b/510/TumorCenter_CD3_block9_x6_y9_patient510_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5587e3db5cbbc76b5ea1e14edb880ed2371103dc --- /dev/null +++ b/510/TumorCenter_CD3_block9_x6_y9_patient510_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 28584.9, + "Num Detections": 12300, + "Num Negative": 11001, + "Num Positive": 1299, + "Positive %": 10.56, + "Num Positive per mm^2": 924.11 + } +} \ No newline at end of file diff --git a/510/TumorCenter_CD8_block9_x5_y9_patient510_0.json b/510/TumorCenter_CD8_block9_x5_y9_patient510_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8ad12c95f91f86cb3aa2c59e1045339ae04457d5 --- /dev/null +++ b/510/TumorCenter_CD8_block9_x5_y9_patient510_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17057.4, + "Centroid Y µm": 23887.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/510/TumorCenter_CD8_block9_x6_y9_patient510_1.json b/510/TumorCenter_CD8_block9_x6_y9_patient510_1.json new file mode 100644 index 0000000000000000000000000000000000000000..223a1e48b3d0e1785e25ee6faf7302760f36c00a --- /dev/null +++ b/510/TumorCenter_CD8_block9_x6_y9_patient510_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19078.8, + "Centroid Y µm": 23939.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/510/history_text.txt b/510/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..49c9c244ac267eb5d0b5072d2e2021b889cc5e57 --- /dev/null +++ b/510/history_text.txt @@ -0,0 +1 @@ +There is morphological and clinical evidence of a high-grade hypopharyngeal carcinoma with an exuding large cervical lymph node metastasis on the right side. After exclusion of distant metastasis, indication for the above-mentioned procedure. \ No newline at end of file diff --git a/510/icd_codes.txt b/510/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0b3cbae91d0de18b52f016f4fb0eb0aee9e11c88 --- /dev/null +++ b/510/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] \ No newline at end of file diff --git a/510/ops_codes.txt b/510/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5e585b266f1bfa2b2043b5295ae87fa89a4ba730 --- /dev/null +++ b/510/ops_codes.txt @@ -0,0 +1 @@ +Direkte Hypopharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Laserkoagulation Pharynxgewebe[5-292.31 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit gestieltem Fernlappen[5-295.05 ] Radikale Neck dissection in 4 Regionen[5-403.10 R] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 L] Permanente Tracheotomie[5-312.0 ] PEG-Sonde Anlage[5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/510/patient_clinical_data.json b/510/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c5985049ea65e84420b4f2f1602adb946a4c4457 --- /dev/null +++ b/510/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 73, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/510/patient_pathological_data.json b/510/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ed94d9e5501ba01535ef86609e0ece5682ac4849 --- /dev/null +++ b/510/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "510", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 26.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/510/surgery_description.txt b/510/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8acac35e2871bb092503ebce47063ee5c83ac0b8 --- /dev/null +++ b/510/surgery_description.txt @@ -0,0 +1 @@ +Laserresektion, Neck dissection sowie Tracheotomie, PEG-Anlage diff --git a/510/surgery_report.txt b/510/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..76ddb40b56fcd3b6cb08258ca32d71cb36d7dd35 --- /dev/null +++ b/510/surgery_report.txt @@ -0,0 +1 @@ +Dictation : After induction of anesthesia and intubation by the anesthesia colleagues, entry with the small bore tube and inspection of the hypopharynx. An exophytic process measuring approx. 2-3 cm can be seen at the entrance to the piriform sinus on the medial and anterior side. The tip of the piriform sinus is free. This shows the exophytic mass measuring approx. 2-3 cm. It is located on the anterior and medial side wall of the piriform sinus. The tip is free. The lateral wall is also free. The process also extends into the postcricoid region. Adjustment of the process with the spread laryngoscope and activation of the laser and microscope. Start cutting around the tumor on the medial side wall and gradually remove it. Hemostasis is achieved using monopolar coagulation or vascular clips. To be on the safe side, another resection is performed on the medial wall, as the margin was relatively narrow after removal of the tumor in toto. Both are suture-marked for the frozen section. The frozen section still shows an invasive carcinoma in the mediocaudal area. A generous resection is performed here, including a margin sample, which is again sent to the frozen section. Final R0 situation. This results in a large wound area. Therefore decision to perform a tracheostomy. PEG placement using the thread pull-through method. Successful with good diaphanoscopy. Neck dissection on the right in the meantime. Externally a 5-6 cm metastasis breaking through the skin at level Va to b. Skin incision at the anterior edge of the sternocleidomastoid muscle and in the area of the metastasis around the mass. Exposure of the platysma in the anterior upper area. Formation of a platysma flap. Exposure of the submandibular gland. Exposure of the sternocleidomastoid muscle. This also shows that the metastasis under the skin also infiltrates the sternocleidomastoid muscle in the cranial region. For this reason, the sternocleidomastoid is deposited in the caudal region at the base and the metastasis is deposited from caudal to cranial, sparing the cervical vascular sheath. The metastasis also infiltrates the cervical plexus, which must be completely removed except for a few small branches. The vagus nerve remains intact as it can be pushed away by the tumor. The border cord cannot be completely spared from the tumor. The accessory nerve is also removed. Ultimately, the hypoglossus remains at the top. During dissection, the subclavian vein is torn in the caudal area. This resulted in severe bleeding, which could be sutured over. The result is an hourglass-shaped structure that leads to narrowing of the vein but is still pervious. During the treatment of the subclavian hemorrhage, the outlet of the internal jugular vein was also torn, which ultimately had to be removed. However, deeper accompanying veins could be preserved. V. Bezas: Neck dissection on the left: Skin disinfection on the left and injection of 6 ml mixed solution of Ultracaine with 2% Suprarenin added in the area of the anterior border of the sternocleidomastoid muscle. Sterile washing and draping. Creation of a skin incision on the anterior border of the sternocleidomastoid muscle. Dissection in depth and identification of the platysma. This is cut sharply. Now lift off a subplatysmal flap anteriorly and posteriorly. Further dissection in depth and identification of the superficial cervical fascia. Now identify the external jugular vein and auricular nerve. The great auricular nerve is completely spared and the external jugular vein is coagulated and cut. Now identify the sternocleidomastoid and dissect in depth along the muscles. First dissection in the level II b area until the digastric muscle is identified. Now dissect further along the digastric muscle until the accessor nerve is identified. Tissue above the accessorius nerve is sharply separated and the remaining tissue from level II b is pulled under the accessorius. Further dissection in the area of level II a up to the identification of the facial vein. Here a resection is performed below the submandibular gland. The marginal ramus nerve and facial nerve are not exposed during the preparation. Now clear Level II a until the hypoglossal nerve is identified. The hypoglossal nerve and internal carotid artery are exposed and spared. Now dissect further downwards along the sternocleidomastoid muscle to below the omohyoid muscle. Dissection further laterally up to the identification of the cervical plexus. Further dissection anteriorly above the cervical plexus and prevertebral cervical fascia. Sharp separation of the fatty tissue in level IV and dissection now along the common carotid artery. The fascia of the cervical vascular sheath is largely spared here. Now lift the preparation cranially and complete the dissection in level IV and level III above the internal jugular vein. Further dissection along the omohyoid muscle and infrahyoid muscles. The complete neck dissection is removed as one piece and sent for histological analysis. Careful hemostasis using ligatures and bipolar forceps. A size 10 Redon drain is placed and the wound is closed step by step once the bleeding has stopped completely. : Lifting of the pectoralis major flap. Measurement of the defect. This results in a 5x7 cm defect that needs to be covered on the neck. The skin island medial to the nipple is configured accordingly. Creation of a skin bridge in the area of the theoretical delto-pectoral flap. Lifting of the skin island from the thoracic wall while protecting the pectoralis minor muscle. Locate and expose the vascular pedicle. Medial separation of the pectoralis major and lateral separation of the pectoralis major from the attachment to the humerus. Finally, most of the muscle is removed. The pedicle is palpable the entire time and the skin island is well supplied with blood. Pull the flap through the skin bridge and fit the graft so that a large muscle patch is positioned in the area of the pharynx. This muscle patch is fixed with sutures and the skin island can be inserted into the skin defect and sutured there. Two Redon drains were previously inserted in the chest area and one in the neck area. Two-layer wound closure in the neck and chest area. At the end, a tracheotomy was created using the visor technique. Insertion into the trachea between the 1st and 2nd tracheal cartilage and creation of a mucocutaneous anastomosis. Patient goes to the intensive care unit for postoperative monitoring. Please set up a diet on the 7th postoperative day without performing an X-ray pre-swallow. Presentation of the patient at the tumor conference to plan adjuvant radiochemotherapy. \ No newline at end of file diff --git a/511/InvasionFront_CD3_block5_x1_y5_patient511_0.json b/511/InvasionFront_CD3_block5_x1_y5_patient511_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d362cb908c3c3c15549550e732c51ec917678458 --- /dev/null +++ b/511/InvasionFront_CD3_block5_x1_y5_patient511_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 12518.4, + "Num Detections": 20039, + "Num Negative": 16914, + "Num Positive": 3125, + "Positive %": 15.59, + "Num Positive per mm^2": 1283.5 + } +} \ No newline at end of file diff --git a/511/InvasionFront_CD3_block5_x2_y5_patient511_1.json b/511/InvasionFront_CD3_block5_x2_y5_patient511_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c2f07073ad876cd637eba2b921cafd6a026172a9 --- /dev/null +++ b/511/InvasionFront_CD3_block5_x2_y5_patient511_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 12643.3, + "Num Detections": 21127, + "Num Negative": 17085, + "Num Positive": 4042, + "Positive %": 19.13, + "Num Positive per mm^2": 1569.2 + } +} \ No newline at end of file diff --git a/511/InvasionFront_CD8_block5_x1_y4_patient511_0.json b/511/InvasionFront_CD8_block5_x1_y4_patient511_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0f228ef93331500595e8607a7bfedad2ed1f2184 --- /dev/null +++ b/511/InvasionFront_CD8_block5_x1_y4_patient511_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4034.4, + "Centroid Y µm": 10221.5, + "Num Detections": 8522, + "Num Negative": 8395, + "Num Positive": 127, + "Positive %": 1.49, + "Num Positive per mm^2": 108.44 + } +} \ No newline at end of file diff --git a/511/InvasionFront_CD8_block5_x2_y4_patient511_1.json b/511/InvasionFront_CD8_block5_x2_y4_patient511_1.json new file mode 100644 index 0000000000000000000000000000000000000000..09daa902169faa08c4379174f662f21a5707321f --- /dev/null +++ b/511/InvasionFront_CD8_block5_x2_y4_patient511_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6647.1, + "Centroid Y µm": 10113.4, + "Num Detections": 11035, + "Num Negative": 10503, + "Num Positive": 532, + "Positive %": 4.821, + "Num Positive per mm^2": 363.74 + } +} \ No newline at end of file diff --git a/511/TumorCenter_CD3_block5_x1_y4_patient511_0.json b/511/TumorCenter_CD3_block5_x1_y4_patient511_0.json new file mode 100644 index 0000000000000000000000000000000000000000..825ac41b5400c2fbccb7f1372663c73d83078c16 --- /dev/null +++ b/511/TumorCenter_CD3_block5_x1_y4_patient511_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5122.3, + "Centroid Y µm": 9145.2, + "Num Detections": 23301, + "Num Negative": 19005, + "Num Positive": 4296, + "Positive %": 18.44, + "Num Positive per mm^2": 1629.3 + } +} \ No newline at end of file diff --git a/511/TumorCenter_CD3_block5_x2_y4_patient511_1.json b/511/TumorCenter_CD3_block5_x2_y4_patient511_1.json new file mode 100644 index 0000000000000000000000000000000000000000..628bde0258136efb5c2884da0c1f965958d89da9 --- /dev/null +++ b/511/TumorCenter_CD3_block5_x2_y4_patient511_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7820.9, + "Centroid Y µm": 9569.9, + "Num Detections": 13983, + "Num Negative": 13075, + "Num Positive": 908, + "Positive %": 6.494, + "Num Positive per mm^2": 505.28 + } +} \ No newline at end of file diff --git a/511/TumorCenter_CD8_block5_x1_y4_patient511_0.json b/511/TumorCenter_CD8_block5_x1_y4_patient511_0.json new file mode 100644 index 0000000000000000000000000000000000000000..07474f35545f7685656578bf0c7cef5fefd42d3a --- /dev/null +++ b/511/TumorCenter_CD8_block5_x1_y4_patient511_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 9794.8, + "Num Detections": 23683, + "Num Negative": 20532, + "Num Positive": 3151, + "Positive %": 13.3, + "Num Positive per mm^2": 1201.8 + } +} \ No newline at end of file diff --git a/511/TumorCenter_CD8_block5_x2_y4_patient511_1.json b/511/TumorCenter_CD8_block5_x2_y4_patient511_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d6ee985f70060de72531c16ed4212b075a64193d --- /dev/null +++ b/511/TumorCenter_CD8_block5_x2_y4_patient511_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6507.1, + "Centroid Y µm": 9825.4, + "Num Detections": 14334, + "Num Negative": 13705, + "Num Positive": 629, + "Positive %": 4.388, + "Num Positive per mm^2": 362.9 + } +} \ No newline at end of file diff --git a/511/history_text.txt b/511/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/511/icd_codes.txt b/511/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc812a96bf6c5b11e6e0b30f5050412ad9dba306 --- /dev/null +++ b/511/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Gaumen, mehrere Teilbereiche überlappend[C05.8 ] \ No newline at end of file diff --git a/511/ops_codes.txt b/511/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..542c38716b90765811c59a2fd12940172c4f081f --- /dev/null +++ b/511/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 6 Regionen[5-403.22 B] Resektion Glandula submandibularis mit intraoperativem Monitoring des Ramus marginalis N. facialis[5-262.41 B] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige radikale Resektion des Pharynx [Pharyngektomie][5-296.xx ] Gaumenbogenkarzinom-Resektion[5-272.1 ] \ No newline at end of file diff --git a/511/patient_clinical_data.json b/511/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bb1f141d2a5418155902cc5f58fb1c06a1d25b05 --- /dev/null +++ b/511/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/511/patient_pathological_data.json b/511/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6150fc51b440bc7a92b8e6909233d0042b7df9ce --- /dev/null +++ b/511/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "511", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/511/surgery_description.txt b/511/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a673ff5d9fa7cbd57a60009e526d02b6cb6f2354 --- /dev/null +++ b/511/surgery_description.txt @@ -0,0 +1 @@ +enorale TU-Resektion, Neck diss bds., Submandibulektomie diff --git a/511/surgery_report.txt b/511/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..04e3fec9ca9e57788476821fd01ddbeb2fc0de51 --- /dev/null +++ b/511/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater and positioning of the patient. Introductory consultation with the anesthesia department. Carrying out the team time-out. Sterile ablation and draping. Start of enoral tumor resection: insertion of a McIvor spatula. There is an ulcerous-appearing mass on the anterior palatal arch on the left side with a diameter of approx. 2.5 cm. Boundaries can be defined directly. The central ulcer is approx. 1 cm in diameter and hard on palpation. The tumor is carefully and successively removed with the ultrasonic knife under palpatory and inspector control. Both the uvula and the posterior palatal arch can be preserved. The tonsil lobe with the lower part of the tonsil is also preserved. The tumor is placed in the muscles of the palatal arch in such a way that sufficient closure is still possible and regurgitation should be avoided. Marking of the specimen after successive hemostasis. The specimen goes to the frozen section. This is R0-resected on the specimen. The penetration depth of the tumor is 3 mm. Laterally, the tumor is resected over 1 cm, basally 3 mm. As a further resection in depth would result in a large defect with subsequent flap coverage and the patient has a history of internal diseases, it is decided to leave the distance of 3 mm in depth for R0 resection. Repositioning and performing the neck dissection on the left side: skin incision and dissection through the subcutaneous fatty tissue. Splitting of the platysma and exposure of the anterior border of the sternocleidomastoid muscle. Dissection along the omohyoid muscle and finding the submandibular gland. Pulling up the submandibular glanula and exposing the posterior digastric venter. Trace it in the direction of level II b. Several metastasis-related masses can be seen here, including an approx. 4 cm mass above the accessorius nerve. This can be carefully pushed away from the accessorius nerve as well as from the internal jugular vein and the facial vein. The accessory nerve and the hypoglossal nerve can be spared. Further free preparation of the internal jugular vein and successive removal of the lateral neck preparation while sparing the brachial plexus. Successive removal of the medial neck preparation. The cervical nerve and hypoglossal nerve are exposed and preserved. The vagus nerve is also identified and can be preserved. A metastasis is palpated above the submandibular gland at level I b. This was also visualized sonographically. For this reason, successive removal of the submandibular gland on the left side. Ligation of the excretory duct. The lingual nerve with its loop was identified and spared. Successive removal of level I b. For this purpose, the marginal ramus of the facial nerve above the facial vein is first exposed and followed. A total of 6 small branches can be exposed. Ligation and removal of the facial vein and folding it upwards. Successive removal of region I a and I b so that the mandible is subsequently exposed and can be seen. Also removal of level I a. Successive hemostasis. Insertion of a Redon drain and two-layer wound closure. Neck dissection on the right: The incision is made in a curved line at the front edge of the sternocleidomastoid muscle. Use the 15 mm scalpel to sharply cut through the skin and subcutaneous tissue and platysma. Dissection of the subplatysmal flap. Dissection of the anterior margin of the sternocleidomastoid muscle. Dissection of the omohyoid muscle. Exposure of the submandibular gland, the accessorius nerve and the posterior belly of the digaster. Now the anterior neck preparation is also removed at the jugulofacial angle and medial to the cervical vascular sheath. The hypoglossal nerve is exposed and spared as well as the external and internal carotid arteries. The lateral preparation is now resected, starting with level II b to V b on the right side. There is an anastomosis between the accessorius nerve and the deep cervical plexus on the right side. No chyle fistula, no injury to the surrounding structures. Dissection of the internal jugular vein leads to a small tear in the vein, which is treated with 6-0 Vascufil. The submandibular gland to the right of the gland is then dissected out after the facial vein has been cut, ligated and folded up in order to protect the oral branch of the facial nerve. The gland is dissected and the mylohyoid muscle is exposed. Exposure of the lingual nerve. The duct is severed and ligated. Also the facial artery. Removal of the gland and complete evacuation of levels I b and I a. Punctual hemostasis. Insertion of a 10-gauge Redon drain and two-layer wound closure using 4-0 Vicryl and 5-0 Ethilon. \ No newline at end of file diff --git a/512/InvasionFront_CD3_block12_x3_y12_patient512_0.json b/512/InvasionFront_CD3_block12_x3_y12_patient512_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f0411d3285f9a37190455f19e99d0a936e31c43 --- /dev/null +++ b/512/InvasionFront_CD3_block12_x3_y12_patient512_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10219.6, + "Centroid Y µm": 34306.8, + "Num Detections": 8580, + "Num Negative": 8573, + "Num Positive": 7, + "Positive %": 0.0816, + "Num Positive per mm^2": 6.259 + } +} \ No newline at end of file diff --git a/512/InvasionFront_CD3_block12_x4_y12_patient512_1.json b/512/InvasionFront_CD3_block12_x4_y12_patient512_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cb0a017f9d0c807b80c98cce30c8756da32201de --- /dev/null +++ b/512/InvasionFront_CD3_block12_x4_y12_patient512_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12768.2, + "Centroid Y µm": 34556.7, + "Num Detections": 18047, + "Num Negative": 17900, + "Num Positive": 147, + "Positive %": 0.8145, + "Num Positive per mm^2": 78.74 + } +} \ No newline at end of file diff --git a/512/InvasionFront_CD8_block12_x3_y12_patient512_0.json b/512/InvasionFront_CD8_block12_x3_y12_patient512_0.json new file mode 100644 index 0000000000000000000000000000000000000000..002525f8e0438e7cb861ff08fff3c2d15bf06fbc --- /dev/null +++ b/512/InvasionFront_CD8_block12_x3_y12_patient512_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12668.3, + "Centroid Y µm": 33457.8, + "Num Detections": 8637, + "Num Negative": 8629, + "Num Positive": 8, + "Positive %": 0.0926, + "Num Positive per mm^2": 7.435 + } +} \ No newline at end of file diff --git a/512/InvasionFront_CD8_block12_x4_y12_patient512_1.json b/512/InvasionFront_CD8_block12_x4_y12_patient512_1.json new file mode 100644 index 0000000000000000000000000000000000000000..13d6a58ba525b9519389e9cceaa04d9938765f2c --- /dev/null +++ b/512/InvasionFront_CD8_block12_x4_y12_patient512_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15391.9, + "Centroid Y µm": 33461.4, + "Num Detections": 17320, + "Num Negative": 17182, + "Num Positive": 138, + "Positive %": 0.7968, + "Num Positive per mm^2": 77.02 + } +} \ No newline at end of file diff --git a/512/TumorCenter_CD3_block12_x3_y12_patient512_0.json b/512/TumorCenter_CD3_block12_x3_y12_patient512_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a8ebfd0797d490e37431ecd80d3a8dc8524110dd --- /dev/null +++ b/512/TumorCenter_CD3_block12_x3_y12_patient512_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10394.5, + "Centroid Y µm": 29484.4, + "Num Detections": 10761, + "Num Negative": 10528, + "Num Positive": 233, + "Positive %": 2.165, + "Num Positive per mm^2": 166.56 + } +} \ No newline at end of file diff --git a/512/TumorCenter_CD3_block12_x4_y12_patient512_1.json b/512/TumorCenter_CD3_block12_x4_y12_patient512_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eeaef274a821a89a412d4d8c88eba48ff6afbe0d --- /dev/null +++ b/512/TumorCenter_CD3_block12_x4_y12_patient512_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12768.2, + "Centroid Y µm": 29709.3, + "Num Detections": 10615, + "Num Negative": 10459, + "Num Positive": 156, + "Positive %": 1.47, + "Num Positive per mm^2": 89.22 + } +} \ No newline at end of file diff --git a/512/TumorCenter_CD8_block12_x3_y12_patient512_0.json b/512/TumorCenter_CD8_block12_x3_y12_patient512_0.json new file mode 100644 index 0000000000000000000000000000000000000000..62b77931e033738e3dc62a53e0217354d9cf4238 --- /dev/null +++ b/512/TumorCenter_CD8_block12_x3_y12_patient512_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13018.1, + "Centroid Y µm": 38929.4, + "Num Detections": 14298, + "Num Negative": 14163, + "Num Positive": 135, + "Positive %": 0.9442, + "Num Positive per mm^2": 72.49 + } +} \ No newline at end of file diff --git a/512/TumorCenter_CD8_block12_x4_y12_patient512_1.json b/512/TumorCenter_CD8_block12_x4_y12_patient512_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd74fa3ef6f17149c269a703515d41a7a8a5cde0 --- /dev/null +++ b/512/TumorCenter_CD8_block12_x4_y12_patient512_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15566.8, + "Centroid Y µm": 39104.3, + "Num Detections": 14855, + "Num Negative": 14434, + "Num Positive": 421, + "Positive %": 2.834, + "Num Positive per mm^2": 219.17 + } +} \ No newline at end of file diff --git a/512/history_text.txt b/512/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..54bea6b55ea9945389066b6b1b6fe41f8b081adf --- /dev/null +++ b/512/history_text.txt @@ -0,0 +1 @@ +In the patient, an extensive hypopharyngeal carcinoma with laryngeal infiltration was histologically confirmed as a squamous cell carcinoma during a panendoscopy, and a tracheotomy was performed in the presence of extensive edema. Overall difficult visualization of the tumor borders. CT showed hypopharyngeal carcinoma with extensive destruction of the larynx on the left side and also cN3 metastasis with a long wall around the ACC without definite signs of infiltration. A preoperative occlusion test showed a regular and sufficient collateral circulation. After extensive internal clarification and therapy optimization in the multimorbid patient as well as after detailed explanatory discussions with reduced therapy options, the decision was made to perform primary radical surgery. \ No newline at end of file diff --git a/512/icd_codes.txt b/512/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6498df6028bb3f338253eda1f6ab7f1ff9203c82 --- /dev/null +++ b/512/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/512/ops_codes.txt b/512/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b2d24a125d5e4a4ffafa0ccb0c7bf4d1767a3118 --- /dev/null +++ b/512/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal: 6 Regionen[5-403.12 L] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 5 Regionen[5-403.21 R] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Destruktion: Elektrokoagulation[5-292.30 ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Exzision, lokal[5-292.0 ] Partielle Resektion des Pharynx [Pharynxteilresektion]: Durch Pharyngotomie: Rekonstruktion mit gestieltem Fernlappen[5-295.15 ] Laryngektomie: Mit Pharyngektomie: Rekonstruktion mit gestieltem Fernlappen[5-303.15 ] Gestielte Fernlappenplastik an der Brustwand[5-905.2a ] \ No newline at end of file diff --git a/512/patient_clinical_data.json b/512/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f1009053116e54302d07e41c70a8c58d54d5c8b0 --- /dev/null +++ b/512/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/512/patient_pathological_data.json b/512/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..554b0501da9d683d861c016918cb982176d69ea3 --- /dev/null +++ b/512/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "512", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/512/surgery_description.txt b/512/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2dbb8854800b061a278f4497f7d12b0d28710102 --- /dev/null +++ b/512/surgery_description.txt @@ -0,0 +1 @@ +Teilpharyngektomie mit Laryngektomie, Neck dissection diff --git a/512/surgery_report.txt b/512/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ca33a596f8f559155cf5317f1a35f9a343364c9 --- /dev/null +++ b/512/surgery_report.txt @@ -0,0 +1 @@ +Initially after induction and preparation by the anesthesia colleagues. Performing a pharyngo-laryngoscopy to determine the extent of the tumor again. Entry with the Kleinsasser tube under dental protection. This reveals pronounced edema of the left aryepiglottic fold with marked edema of the left arytenoid. The endolarynx is barely adjustable. There is an exophytic, exulcerated tumor in the area of the left piriform sinus with pronounced induration and palpatory high-grade v.a. continuous growth into the soft tissues of the neck, which corresponds to the CT imaging. The free entrance to the esophagus and the piriform sinus on the right side are tumor-free, as is the posterior pharyngeal wall. The exophytic area just does not reach this. Therefore, repositioning for resection from the outside. First elevation of an apron flap incision to just above the tracheostoma. Here, with the tracheostoma clearly torn out preoperatively and a very short neck, the incision is made just above the tracheostoma. Cranial preparation of the apron flap and suture fixation. Start with neck dissection of the left side. Palpation reveals an extensive, extremely hard and barely mobile neck metastasis. Initially caudal and cranial exposure of the sternocleidomastoid muscle. First visualization, later removal of the external jugular vein and the auricularis magnus nerve in case of safe infiltration by the metastasis Removal of the sternocleidomastoid muscle cranially and caudally. Exposure of the omohyoid muscle is not possible with complete infiltration. Visualization of the submandibular gland. Infiltration can also be seen later on. The same applies to the digastric muscle. This is visualized posteriorly and anteriorly and severed. First release of the mass, which extends caudally to level Vb. Careful release and preservation of the brachial plexus, which is not infiltrated. Release and preserve the cervical transverse artery and vein. Strict control of lymphatic leakage. Protection of the subclavian vein. Partial resection of the cervical plexus in case of infiltration, accessorius nerve can no longer be visualized in case of infiltration. Partial thyroidectomy in case of questionable infiltration of the upper pole, here clear adherence of the tumor. In the case of extensive destruction of the larynx and suspected continuous growth, no further visualization of the laryngeal skeleton. Cranial exposure of the tumor with resection of the submandibular gland and description of the digastric muscle. Caudal exposure of the long infiltrated internal jugular vein, which is placed caudally. Difficult visualization of the arteria carotis communis and the vagus nerve, which are displaced very far caudally and to the depth. These are initially free caudally. Exposure of the prevertebral fascia; a free layer can be exposed here. Now successively expose the largely walled-in common carotid artery, initially walled in far to the cranial in the area of the internal carotid artery, the vagus nerve must be removed if infiltration is safe. Consultation and demonstration of findings at . The metastasis is now opened selectively to better expose the internal carotid artery. The internal carotid artery can be preserved by dissecting all vascular layers. No reliable evidence of infiltration. The external carotid artery is completely walled in close to the outlet without the possibility of free dissection, therefore the artery is removed after puncture and ligation. Resection of the hypoglossal nerve, careful dissection of a metastatic cone in the direction of the base of the skull in the case of long infiltration, extremely difficult dissection conditions and clear adherence. The extension ends here in a rough tissue alteration. A representative marginal sample is taken here later. Finally, the metastasis can be removed from the neck area. Only the prevertebral fascia, parts of the paravertebral musculature and the common carotid artery with the internal carotid artery and remnants of the cervical plexus remain. Now free preparation of the larynx on the right side, exposure of the hyoid, which is also infiltrated on the left side. Release of the piriform sinus, entering the vallecula above the hyoid. Looping of the epiglottis. After opening the pharynx wide in the pharyngotomy along the aryepiglottic fold on the right, successive gaining of an overview of the tumorous process. Significant aryoedema. Therefore postcricoid removal of approx. 1 cm of postcricoid mucosa. Resection of the tumor with a safety margin of approx. 1-1.5 cm. Release of the cricoid cartilage. Mobilization up to the trachea after previously performed right-sided thyroidectomy. Exposure of the free esophageal entrance and resection of the tumor in toto with the attached cervical metastasis, after removal below the cricoid cartilage while taking the first tracheal clasp subglottically, certainly no tumor growth, but with previous tracheotomy removal of a marginal sample in the area of the posterior tracheal wall in scarred conditions. In addition, completely covering mucosal margin samples. The frozen section diagnosis now shows a positive marginal sample in the area of the posterior tracheal wall and residual infiltrates in the area of the skull base with tumor-free marginal samples in the area of the primaries. Therefore, obtaining a post-resectate in the area of the skull base. Extensive release of any soft tissue area of the skull base while sparing the internal carotid artery. This is removed as a post-resectate for definitive histology. Final marginal sample in the area of soft tissue remnants, these are diagnosed as tumor-free in the frozen section, also in the area of the posterior wall of the trachea Removal of the posterior wall of the trachea and the surrounding soft tissue. A resection is also made here. A representative final marginal sample is then taken, which is also diagnosed as tumor-free. Due to the now clearly resected posterior tracheal wall, it is not necessary to insert a provox prosthesis at this point. Now to the neck dissection of the right side. Exposure of the sternocleidomastoid muscle. Exposure and preservation of the external jugular vein and the auricularis magnus nerve. Exposure of the omohyoid muscle. This has already been dissected from the laryngeal skeleton. Exposure of the submandibular gland and the digasatric muscle. Exposure of a very strong facial venous branch, which appears to flow into the jugularis anterior current area; this is ligated and deposited in the transverse course. Exposure and dissection of the internal jugular vein. Release of the anterior neck preparation with partial ligation of the superior thyroid artery. Preservation of the hypoglossal nerve. Exposure of the accessorius nerve. Clearing of the accessorius triangle. In the area of the cranial muscle part of the sternocleidomastoid muscle, a coarse, macroscopically altered area can be seen here, partly scarred, but partly also appearing tumorously altered. Likewise in the area of the middle of the muscle, also scarred, dd tumorous area. Therefore resection of both areas. Subsequent complete excision of the accessorius triangle and level V, sparing the cervical plexus branches. Finally, wound inspection and, if the wound is dry, evaluation of the pharyngeal defect. An intact, strong residual pharyngeal tube is found, but with a clear tendency towards stenosis, particularly cranially, and in the case of primary occlusion, the common carotid artery or internal carotid artery is also unprotected over a long distance. Therefore, after initial preparation for ALT removal on the left, demonstration of findings and case discussion with . Due to the co-mobility with known vascular disease, treatment using a pedicled pectoralis major graft is preferred to defect coverage using a microvascular graft. A defect of approx. 8 x 7 cm is measured in the area of the pharynx. If secondary reconstruction is required, a temporary deltopectoral flap is lifted first. Signs of the pectoralis major graft. Elevation of the deltopectoral flap up to the second angiosome. Separation of skin and subcutaneous tissue. Exposure of the deltoid muscle. Strictly subfascial dissection. Protection of the Mohrenheim fossa and the cephalic vein. After medial preparation and moistening of the transient graft, resection of the pectoralis major graft. After cutting around the skin island, lift a broad muscle head laterally to cover the soft tissue in the area of the carotid artery. Release of the pectoralis muscle, strictly suprafascial preparation, exposure of the pectoralis minor. Cranial dissection with careful protection of the vascular pedicle after reliable identification of the latter. Leave a muscle cup to protect the vascular pedicle. Dissection of the vascular pedicle up to the Mohrenheim fossa, then complete resection of the attached pectoralis major muscle. The skin island can then be inserted into the pharyngeal defect completely tension-free. After insertion, a very wide skin tunnel without any tendency to tension can be seen. Therefore tunneling through the flap pedicle. Suture the skin island into the pharyngeal defect with 3.0 mucosal sutures. This works well and fits perfectly. Then cover the internal carotid artery with the attached muscle graft. This allows the artery to be covered with muscle along its entire length. After inspection of all wound cavities, two 10-gauge Redon drainage tubes are inserted pectorally and one 10-gauge Redon drainage tube is inserted on the left side; drainage on the right side must be omitted in the event of repeated loss of suction due to the tracheostoma arrangement. Subsequent careful two-layer wound closure. The tracheostoma should be sutured beforehand. Adaptation of the anterior skin. Due to the tension already present here, a tracheostoma resection is not performed anteriorly. Healthy granulation tissue on all sides and already existing wound healing disorder, therefore no further measures here. The tracheostoma ends caudally over the apron flap. The procedure is then completed without any indication of complications. The patient received intraoperative antibiotics with Unacid 3 g. Conclusion: cT4a hypopharyngeal carcinoma on the left with extremely aggressive and per continuitatem growing neck metastasis on the left, in this case an extended, radical neck dissection was performed, taking all neck structures with it except for the common carotid artery. Intraoperatively, the situation was clearly R0 with regard to the primary tumor. Due to the aggressive metastasis, exhaustion of adjuvant therapy options is certainly necessary. Postoperatively, due to the neck situation on the left, rapid indication for surgery if a fistula is detected, otherwise it is recommended to carry out an X-ray pelvis on the 10th postoperative day. After completion of wound healing, a secondary Provox treatment appears conceivable in the interval. \ No newline at end of file diff --git a/513/InvasionFront_CD3_block10_x5_y4_patient513_0.json b/513/InvasionFront_CD3_block10_x5_y4_patient513_0.json new file mode 100644 index 0000000000000000000000000000000000000000..26e6720df39d2917139f0217bdd09ff8d708b5e8 --- /dev/null +++ b/513/InvasionFront_CD3_block10_x5_y4_patient513_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 15641.7, + "Num Detections": 29073, + "Num Negative": 20683, + "Num Positive": 8390, + "Positive %": 28.86, + "Num Positive per mm^2": 2810.3 + } +} \ No newline at end of file diff --git a/513/InvasionFront_CD3_block10_x6_y4_patient513_1.json b/513/InvasionFront_CD3_block10_x6_y4_patient513_1.json new file mode 100644 index 0000000000000000000000000000000000000000..de4b5321adad3abf78187764a1654e1b1bfe46a7 --- /dev/null +++ b/513/InvasionFront_CD3_block10_x6_y4_patient513_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21588.6, + "Centroid Y µm": 15866.6, + "Num Detections": 28861, + "Num Negative": 19525, + "Num Positive": 9336, + "Positive %": 32.35, + "Num Positive per mm^2": 3242.2 + } +} \ No newline at end of file diff --git a/513/InvasionFront_CD8_block10_x5_y4_patient513_0.json b/513/InvasionFront_CD8_block10_x5_y4_patient513_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f7481aa5730b7314a9e67ba04737de6e6b3f8aed --- /dev/null +++ b/513/InvasionFront_CD8_block10_x5_y4_patient513_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 15666.7, + "Num Detections": 34529, + "Num Negative": 26767, + "Num Positive": 7762, + "Positive %": 22.48, + "Num Positive per mm^2": 2605.7 + } +} \ No newline at end of file diff --git a/513/InvasionFront_CD8_block10_x6_y4_patient513_1.json b/513/InvasionFront_CD8_block10_x6_y4_patient513_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc80e6dc3fb570f2e8588adfd545d15f7e94698d --- /dev/null +++ b/513/InvasionFront_CD8_block10_x6_y4_patient513_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20664.1, + "Centroid Y µm": 15891.6, + "Num Detections": 34674, + "Num Negative": 30364, + "Num Positive": 4310, + "Positive %": 12.43, + "Num Positive per mm^2": 1510.1 + } +} \ No newline at end of file diff --git a/513/TumorCenter_CD3_block10_x5_y4_patient513_0.json b/513/TumorCenter_CD3_block10_x5_y4_patient513_0.json new file mode 100644 index 0000000000000000000000000000000000000000..79c513d18c876399a2ba4af894fe222db276d5fc --- /dev/null +++ b/513/TumorCenter_CD3_block10_x5_y4_patient513_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 9769.8, + "Num Detections": 24764, + "Num Negative": 21789, + "Num Positive": 2975, + "Positive %": 12.01, + "Num Positive per mm^2": 1209.0 + } +} \ No newline at end of file diff --git a/513/TumorCenter_CD3_block10_x6_y4_patient513_1.json b/513/TumorCenter_CD3_block10_x6_y4_patient513_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e127f777ee3ee08552b4f97572e3afba16dee79 --- /dev/null +++ b/513/TumorCenter_CD3_block10_x6_y4_patient513_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21538.6, + "Centroid Y µm": 9644.9, + "Num Detections": 28701, + "Num Negative": 25084, + "Num Positive": 3617, + "Positive %": 12.6, + "Num Positive per mm^2": 1245.2 + } +} \ No newline at end of file diff --git a/513/TumorCenter_CD8_block10_x5_y4_patient513_0.json b/513/TumorCenter_CD8_block10_x5_y4_patient513_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5ce1c0624846654707f2b4ae4fa79bc99925ebcd --- /dev/null +++ b/513/TumorCenter_CD8_block10_x5_y4_patient513_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 10219.6, + "Num Detections": 24793, + "Num Negative": 22121, + "Num Positive": 2672, + "Positive %": 10.78, + "Num Positive per mm^2": 1220.4 + } +} \ No newline at end of file diff --git a/513/TumorCenter_CD8_block10_x6_y4_patient513_1.json b/513/TumorCenter_CD8_block10_x6_y4_patient513_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ed6857b633d73575709f41a77048c23e50ab65a --- /dev/null +++ b/513/TumorCenter_CD8_block10_x6_y4_patient513_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 10044.7, + "Num Detections": 31362, + "Num Negative": 26860, + "Num Positive": 4502, + "Positive %": 14.35, + "Num Positive per mm^2": 1571.6 + } +} \ No newline at end of file diff --git a/513/history_text.txt b/513/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..95ac9e1ff84f6319ca463236a50d3f3b612f12fb --- /dev/null +++ b/513/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed oropharyngeal carcinoma. This extends from the tonsillar lobe on the right over the palatal arch to the tonsillar lobe on the left. Relatively superficial but extensive growth. Histologically confirmed squamous cell carcinoma. \ No newline at end of file diff --git a/513/icd_codes.txt b/513/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d5389c2dbfcb004c7994ba0ac2fd9bc15dfd53c --- /dev/null +++ b/513/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Vestibulum oris[C06.1 ] \ No newline at end of file diff --git a/513/ops_codes.txt b/513/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/513/patient_clinical_data.json b/513/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b8529736590c36a42549479661cc1e6b4dd196b8 --- /dev/null +++ b/513/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 46, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/513/patient_pathological_data.json b/513/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e17c0fc7049064aa8464bd414666568491cf7e84 --- /dev/null +++ b/513/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "513", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 38, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/513/surgery_description.txt b/513/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..979539fb2d2864b95ab3e5f93252c76025812f75 --- /dev/null +++ b/513/surgery_description.txt @@ -0,0 +1 @@ +Partielle Resektion Pharynx, Neck dissection, Freier Lappen (Radialis), Tracheotomie, PEG-Anlage diff --git a/513/surgery_report.txt b/513/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4ccae0c89808531102655395c653663148c931f2 --- /dev/null +++ b/513/surgery_report.txt @@ -0,0 +1 @@ +() Insertion of a tonsil plug and inspection of the tumor region. The tumor appears on both sides in the area of the soft palate, covers the uvula with the base of the uvula, but can be palpated rather superficially and then extends further down to the left tonsil lobe, covers the left tonsil and also passes macroscopically to the border of the upper pole of the tonsil on the right. Here, the mucosa is first cut around the soft palate with the monopolar needle. Then dissect with scissors and bipolar forceps. A safety distance of 1 ˝ to 2 cm is selected so that the entire soft palate must be removed in the mucosal area. The uvula is also removed, but the muscular tissue at the base of the uvula can be preserved. Further tumor resection in the area of the glossoalveolar groove and removal of the left tonsil. Then transition to the right side and removal of the right tonsil as well. The tumor specimen can be retrieved in its entirety and sent for histological examination marked with a thread. Then marginal samples are taken. The marginal samples are described as tumor-free except for the oropharyngeal side wall in the area of the glossoalveolar groove. There was still carcinoma in situ at this location, which is resected and can ultimately be designated as R0 in a frozen section margin sample. Neck dissection on both sides, initially starting on the left side. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, the submandibular gland. Finding the accessorius nerve. Then exposure of the cervical vascular sheath and free preparation of the internal jugular vein. Level II shows clearly enlarged lymph nodes. Evacuation of level II, III, IV and V, sparing the plexus branches, the hypoglossal nerve, the border cord and the internal jugular vein, external and internal carotid artery, external jugular vein and superior thyroid artery. The facial artery was ligated. Then transition to neck dissection on the right side. In principle, the same procedure is used here. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and the submandibular gland. Then visualization of the accessorius nerve. Exposure of the cervical vascular sheath and free preparation of the internal jugular vein. Evacuation of levels II, III, IV and V, sparing all structures. Then transition to tracheotomy. Skin incision just below the cricoid cartilage and dissection down to the thyroid gland. This is exposed in the isthmus area, undermined, clamped, severed and ligated. The trachea is then exposed. Entry between the 2nd and 3rd tracheal cartilage and creation of a visor tracheotomy without incision of a Björk flap and epithelialization of the skin in the sense of a mucocutaneous anastomosis. () After creating the R0 resection, the defect is now measured enorally. The defect extends from the hypopharyngeal entrance on the left over the entire soft palate to the hypopharyngeal entrance on the right. Defect length approx. 14 cm, width approx. 6 cm. A flap with dimensions of up to approx. 14.5 cm x 6 cm is made on the forearm. The tourniquet is then created. Now cut around the flap, initially from ulnar subfascial. Extension of the incision curved towards the crook of the elbow. Exposure of the superficial venous system, which is integrated into the pedicle. The flap is then recut from the radial subfascial side. Exposure of the radial artery. This is clamped off, severed and supplied using 4-0 Prolene puncture ligatures. Subfascial elevation of the flap along the vascular pedicle. Outgoing vessels are coagulated bipolar or treated with clips. The pedicle is exposed below the brachioradialis muscle and dissected out. Superficial venous system integrated into the pedicle. The connection between the superficial and deep venous system is exposed and preserved in the area of the crook of the elbow. Good confluence of the radial vein and good drainage via the cephalic vein is shown. The radial artery is visualized up to the entrance of the brachial artery. Then open the clamp, good reperfusion. Extensive hemostasis again. The flap is left on the perfusion until it is possible to suture it. The flap is then removed, the veins ligated and the brachial artery ligated using a 4-0 Prolene. Flap is flushed with heparin. The flap is then inserted into the defect. This is done successively with 3-0 single button sutures. Tension-free suturing under relatively difficult conditions with a relatively small mouth opening. The flap is sutured in correctly in three dimensions. A tunnel approx. 3 transverse fingers wide was previously created from the pharyngeal area into the left side of the neck. The vascular pedicle was passed through this. Conditioning of the vessels, initially the superior thyroid artery. This is first anastomosed to the conditioned radial artery using 9-0 Ethilon single button sutures. After opening the clamp, however, the pulse is insufficient. Open the suture. No more perfusion via the superior thyroid artery, no blood flow from the bulb even after extensive revision. Therefore now occlusion of the superior thyroid artery. Conditioning of the facial artery shortly after its exit from the external carotid artery. Anastomosis of the newly conditioned radial artery with the conditioned facial artery using 9-0 Ethilon single-button sutures. Here, after opening the clamp, good blood flow, good venous return. Then conditioning of the facial artery shortly before entering the internal jugular vein and suturing with the trimmed radial vein in the confluence area. This is done with a 2.5 mm coupler. The cephalic vein and the internal jugular vein are then conditioned. These are anastomosed using a 1.5 mm coupler. Good venous return after opening the venous clamps. Overall good flap perfusion. This is followed by configuration of the pedicle and suturing in the favored position. Subsequent extensive irrigation of the wound area and hemostasis. Wound closure on both sides of the neck after insertion of a Redon drain, which is guided on the left. Skin closure also takes place with epithelialization of the tracheostoma. The forearm defect is closed using skin from the groin on the right. For this purpose, a piece of full-thickness skin is removed from the groin in the typical manner, according to the dimensions. After mobilization of the skin, the groin is closed in several layers with the insertion of a Redon drain. Low-tension closure. After thinning, the full-thickness skin is sutured into the forearm defect without tension. Hydrogel-Mepilex dressing is applied over this. Loose swabs are placed on top and the arm is wrapped in absorbent cotton. Fitting of a Kramer splint and fixation of the arm to the Kramer splint with an elastic bandage. Forearm always well perfused. Finally, insertion of an 8 mm tracheal cannula, which is fixed with sutures. Skin disinfection. No dressing except for plaster at the incision site. Patient goes to the intensive care unit for postoperative monitoring. Antibiotic treatment with Unacid, as started intraoperatively, should be continued for 2 to 3 days in total. Feeding via the inserted PEG tube for 10 days, then if necessary, diet build-up. Flap control clinically and via Doppler probe at the mark on the left side of the neck according to the usual postoperative scheme for 5 days. Please continue heparin perfusor 500 units per hour for 5 days. Patient should be elevated 30° and ventilated for 1 night postoperatively. Overall extensive, relatively flat growing oropharyngeal carcinoma cN2c cT3 to 4. Postoperatively, according to the histology, discuss radiotherapy vs. radiochemotherapy. \ No newline at end of file diff --git a/514/InvasionFront_CD3_block4_x1_y8_patient514_0.json b/514/InvasionFront_CD3_block4_x1_y8_patient514_0.json new file mode 100644 index 0000000000000000000000000000000000000000..41c2cea38b40a0bb0913bb533deda38752ea5acb --- /dev/null +++ b/514/InvasionFront_CD3_block4_x1_y8_patient514_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 25811.3, + "Num Detections": 25336, + "Num Negative": 24917, + "Num Positive": 419, + "Positive %": 1.654, + "Num Positive per mm^2": 162.76 + } +} \ No newline at end of file diff --git a/514/InvasionFront_CD3_block4_x2_y8_patient514_1.json b/514/InvasionFront_CD3_block4_x2_y8_patient514_1.json new file mode 100644 index 0000000000000000000000000000000000000000..05690c92af560fbeaab2db5f261e331cf6866243 --- /dev/null +++ b/514/InvasionFront_CD3_block4_x2_y8_patient514_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8995.2, + "Centroid Y µm": 25961.3, + "Num Detections": 25512, + "Num Negative": 24158, + "Num Positive": 1354, + "Positive %": 5.307, + "Num Positive per mm^2": 507.02 + } +} \ No newline at end of file diff --git a/514/InvasionFront_CD8_block4_x1_y8_patient514_0.json b/514/InvasionFront_CD8_block4_x1_y8_patient514_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f1f1b9d5f21401df67a695271171322711ebb33b --- /dev/null +++ b/514/InvasionFront_CD8_block4_x1_y8_patient514_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 24886.8, + "Num Detections": 23241, + "Num Negative": 22904, + "Num Positive": 337, + "Positive %": 1.45, + "Num Positive per mm^2": 126.34 + } +} \ No newline at end of file diff --git a/514/InvasionFront_CD8_block4_x2_y8_patient514_1.json b/514/InvasionFront_CD8_block4_x2_y8_patient514_1.json new file mode 100644 index 0000000000000000000000000000000000000000..98c46b29c2696b04bdb479c2570fcb46ce473e66 --- /dev/null +++ b/514/InvasionFront_CD8_block4_x2_y8_patient514_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 24886.8, + "Num Detections": 24126, + "Num Negative": 23586, + "Num Positive": 540, + "Positive %": 2.238, + "Num Positive per mm^2": 200.04 + } +} \ No newline at end of file diff --git a/514/TumorCenter_CD3_block4_x1_y8_patient514_0.json b/514/TumorCenter_CD3_block4_x1_y8_patient514_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f17fcfdfefc635b3496eba4c56ec37107906cf5 --- /dev/null +++ b/514/TumorCenter_CD3_block4_x1_y8_patient514_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 20714.0, + "Num Detections": 25371, + "Num Negative": 22571, + "Num Positive": 2800, + "Positive %": 11.04, + "Num Positive per mm^2": 1032.2 + } +} \ No newline at end of file diff --git a/514/TumorCenter_CD3_block4_x2_y8_patient514_1.json b/514/TumorCenter_CD3_block4_x2_y8_patient514_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8ecee0e5a2d508cfa6407368a302c66bfcfa8de1 --- /dev/null +++ b/514/TumorCenter_CD3_block4_x2_y8_patient514_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 20639.1, + "Num Detections": 23503, + "Num Negative": 21496, + "Num Positive": 2007, + "Positive %": 8.539, + "Num Positive per mm^2": 784.69 + } +} \ No newline at end of file diff --git a/514/TumorCenter_CD8_block4_x1_y8_patient514_0.json b/514/TumorCenter_CD8_block4_x1_y8_patient514_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6f5cc8457bb5c306d51f98630cf530ebfc190c6a --- /dev/null +++ b/514/TumorCenter_CD8_block4_x1_y8_patient514_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 20114.3, + "Num Detections": 28062, + "Num Negative": 26798, + "Num Positive": 1264, + "Positive %": 4.504, + "Num Positive per mm^2": 459.76 + } +} \ No newline at end of file diff --git a/514/TumorCenter_CD8_block4_x2_y8_patient514_1.json b/514/TumorCenter_CD8_block4_x2_y8_patient514_1.json new file mode 100644 index 0000000000000000000000000000000000000000..34c1cd97ecc9b1fc457bad1e9094a4ceeff2d2e2 --- /dev/null +++ b/514/TumorCenter_CD8_block4_x2_y8_patient514_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 20164.3, + "Num Detections": 26762, + "Num Negative": 26165, + "Num Positive": 597, + "Positive %": 2.231, + "Num Positive per mm^2": 227.67 + } +} \ No newline at end of file diff --git a/514/history_text.txt b/514/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f05fe14396cb7a165ca28933a4cdda4c3c1f50d4 --- /dev/null +++ b/514/history_text.txt @@ -0,0 +1 @@ +The patient has been suffering for ˝year from masses in the neck area as well as pain and difficulty swallowing. Panendoscopy revealed an exophytic mass at the glossotonsillar groove with transition to the soft palate. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/514/icd_codes.txt b/514/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adc050c8f628f1e558c676f540ed678cb6876eb8 --- /dev/null +++ b/514/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/514/ops_codes.txt b/514/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8917b38bbaed946c8eae1bdaf5d2c0b6ff6d51fc --- /dev/null +++ b/514/ops_codes.txt @@ -0,0 +1 @@ +Partielle Exzision Mundboden[5-273.6 ] Partielle Exzision [erkrankter] harter und weicher Gaumen[5-272.1 ] Zungentumorexzision[5-250.2 ] Transorale radikale Resektion des Pharynx ohne Rekonstruktion[5-296.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Temporäre Tracheotomie[5-311.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/514/patient_clinical_data.json b/514/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ceed0cdd68fa4b98cab4e8677e74a4cd9c65aded --- /dev/null +++ b/514/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/514/patient_pathological_data.json b/514/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..55a14dfd77ab2ebd0f9766fb2e49fdddb686d664 --- /dev/null +++ b/514/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "514", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 23, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/514/surgery_description.txt b/514/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..742579222bc7538a197c41941c97b02a884814a0 --- /dev/null +++ b/514/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion li., Neck diss. rechts, Tracheotomie diff --git a/514/surgery_report.txt b/514/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad52ace0dd75b7c220dd9cbcf9d804fecdb9a2a6 --- /dev/null +++ b/514/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Entry with the small bore tube and inspection of the tumor. The tumor is located at the base of the tongue on the left side, passes over the glossotonsillar groove into the anterior palate and partly into the soft palate. Then insertion of the spandex and looping of the tongue. Now cut around the tumor with a safety distance of 1.5 to 2 cm using the monopolar needle. Further dissection with scissors, forceps and bipolar coagulation. Tumor resection is very difficult in the posterior sections of the base of the tongue due to a lack of visibility. Finally, the specimen is retrieved in its entirety. A suture mark is placed while still in situ. The specimen is then removed and inspected. There is a safety margin of approx. 1 cm in the entire preparation area. The specimen is placed on cork and sent for frozen section. In the frozen section, all margins are free of carcinoma, including no dysplasia or carcinoma in situ. There are large, palpable neck metastases on the left side, the border to the neck area can no longer be safely spared, therefore a neck dissection on the left side is dispensed with. The patient was not previously informed and prepared for a flap operation. Therefore, the neck dissection is now performed on the right side. Skin spray disinfection in the usual manner. Injection of 10 ml Ultracaine 2% with added Suprarenin in the area of the skin incision on the right. The skin incision corresponds to a curved line on the anterior edge of the sternocleidomastoid, starting below the mastoid to two transverse fingers above the clavicle, at least two transverse fingers on all sides away from the mandibular branch and the angle of the jaw. Then reposition the patient and wash and drape sterilely in the usual manner. Skin incision and sharp separation of the platysma and dissection along the anterior edge of the sternocleidomastoid muscle. Exposure of the accessorius nerve. Exposure of the posterior abdomen of the digaster muscle and the omohyoid muscle. Dissection along the cervical vascular sheath from caudal to cranial. Successive removal of the posterior and anterior neck specimen while protecting the accessorius, the cervical plexus and the hypoglossal nerve, which was exposed and spared. Overall, levels I b, II, III, IV and V were completely removed. The submandibular gland was left intact. Wound irrigation with hydrogen peroxide and Ringer's solution. Dry conditions. Placement of a 10 Redon drain and platysma suture with 3.0 Vicryl and skin suture with 5.0 Ethilon. Due to the large tumor defect, indication for protective tracheostomy, also because no neck dissection could be performed on the corresponding side and the neck is difficult to access in the event of bleeding due to the metastases. Tracheotomy: After careful palpation of the cricoid, skin incision approx. 3 cm above the 2nd tracheal cartilage. Dissect with a scalpel and scissors up to the infrahyal muscles and push the muscles aside. Further dissection up to the thyroid gland, undermining of the thyroid gland, coagulation of the thyroid gland and transection. Now blunt exposure of the trachea with the swab and visor flap incision between the 2nd and 3rd tracheal cartilage. Sutures to the skin, 4 cranial and 4 caudal to the tracheostoma. Now hemostasis by means of focal bipolarization. No bleeding at the end of the operation. Conclusion: cT2 cN2b oropharyngeal carcinoma. Please repeat neck dissection of the left side on two occasions in approx. 3 weeks. Then presentation at the tumor conference with complete TNM classification. Postoperatively, if possible, inclusion of the patient in the study (mention at the tumor conference). \ No newline at end of file diff --git a/515/InvasionFront_CD3_block16_x5_y10_patient515_0.json b/515/InvasionFront_CD3_block16_x5_y10_patient515_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba5e5ac8096cddcc1819784013ebf92781bf36ef --- /dev/null +++ b/515/InvasionFront_CD3_block16_x5_y10_patient515_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16550.8, + "Centroid Y µm": 29334.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/515/InvasionFront_CD3_block16_x6_y10_patient515_1.json b/515/InvasionFront_CD3_block16_x6_y10_patient515_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0051b8437b7c4e50483960ba16d787b34dc48108 --- /dev/null +++ b/515/InvasionFront_CD3_block16_x6_y10_patient515_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18961.4, + "Centroid Y µm": 29521.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/515/InvasionFront_CD8_block16_x5_y10_patient515_0.json b/515/InvasionFront_CD8_block16_x5_y10_patient515_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1ee43e4a8ca5f0c05104e01c23c1f6686101d91b --- /dev/null +++ b/515/InvasionFront_CD8_block16_x5_y10_patient515_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 24780.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/515/InvasionFront_CD8_block16_x6_y10_patient515_1.json b/515/InvasionFront_CD8_block16_x6_y10_patient515_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cbdab5c0e64f05e612d311063e3868685c8e0c08 --- /dev/null +++ b/515/InvasionFront_CD8_block16_x6_y10_patient515_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 24780.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/515/TumorCenter_CD3_block16_x5_y10_patient515_0.json b/515/TumorCenter_CD3_block16_x5_y10_patient515_0.json new file mode 100644 index 0000000000000000000000000000000000000000..16d75f1e1a87de384ff3f609f5767ea6fbb98096 --- /dev/null +++ b/515/TumorCenter_CD3_block16_x5_y10_patient515_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 25686.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/515/TumorCenter_CD3_block16_x6_y10_patient515_1.json b/515/TumorCenter_CD3_block16_x6_y10_patient515_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ba2daa375351ebda85abf5a6736fbf98f06ada3b --- /dev/null +++ b/515/TumorCenter_CD3_block16_x6_y10_patient515_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 25811.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/515/TumorCenter_CD8_block16_x5_y10_patient515_0.json b/515/TumorCenter_CD8_block16_x5_y10_patient515_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c81aaa79e5ccd1d63f2ad3bed95001d07d41b227 --- /dev/null +++ b/515/TumorCenter_CD8_block16_x5_y10_patient515_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 25436.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/515/TumorCenter_CD8_block16_x6_y10_patient515_1.json b/515/TumorCenter_CD8_block16_x6_y10_patient515_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0a280045d01ed0cec23b1f9bf7dfb4f1a7639d78 --- /dev/null +++ b/515/TumorCenter_CD8_block16_x6_y10_patient515_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 25461.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/515/history_text.txt b/515/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/515/icd_codes.txt b/515/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b471b784d2b9d9c09a5a3b27210fcf133740a8a5 --- /dev/null +++ b/515/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 ] \ No newline at end of file diff --git a/515/ops_codes.txt b/515/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0934f1ae6fdae2c28580cd7b16526ddbd28de2a4 --- /dev/null +++ b/515/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument[1-620.1 ] Diagnostische Ösophagogastroskopie[1-631 ] Biopsie sonstiger Strukturen Mund und Mundhöhle durch Inzision[1-545.x ] \ No newline at end of file diff --git a/515/patient_clinical_data.json b/515/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..57f88b0881e9614531c4a10e7ec51b628add0be0 --- /dev/null +++ b/515/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/515/patient_pathological_data.json b/515/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8db60e0593c2371da19bd5ed28dc35005dd18b21 --- /dev/null +++ b/515/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "515", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 28, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/515/surgery_description.txt b/515/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a110bcb47d13a767a65b5445755b26853382240c --- /dev/null +++ b/515/surgery_description.txt @@ -0,0 +1 @@ +Excisionsbiopsie diff --git a/515/surgery_report.txt b/515/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..dea376bd34fd54066aa08f484ddfd0f12601a512 --- /dev/null +++ b/515/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia. Then perform a rigid tracheoscopy. Inconspicuous mucosal conditions here. The patient is then intubated without any problems. Now insertion of the flexible esophagoscope under insufflation. Pre-insufflation into the stomach. Here and on retraction in the area of the esophagus, regular mucosal relief without evidence of exophytic tumor growth. Now repositioning. Insertion of a mouth guard and insertion of a Kleinsasser C-tube. Inspection of the structures of the oropharynx, hypopharynx and endolarynx. Regular mucosa is visible on all sides. Now insertion of an oral retractor. Snare the tongue and inspect the edge of the tongue. On the right side, an approx. 1 x 1.5 cm large, coarse, centrally ulcerated mass can be seen in the posterior third. Demonstration of the findings to . He recommended a complete excision with a safety margin using an electric needle and suture marking. Therefore, proceed according to this recommendation. First mark the resection margins. Then successively cut the fibers of the tongue musculature. Strict care is taken to resect the healthy tissue with a safety margin of a few mm. The tumor can be completely removed and is then suture-marked. Finally, bipolar coagulation is performed to stop the bleeding and, if the wound is dry, the procedure is completed without complications. \ No newline at end of file diff --git a/516/InvasionFront_CD3_block16_x3_y10_patient516_0.json b/516/InvasionFront_CD3_block16_x3_y10_patient516_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2d7d79d4fbbc52ec68ad8f3c2ad7571689f00940 --- /dev/null +++ b/516/InvasionFront_CD3_block16_x3_y10_patient516_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11725.8, + "Centroid Y µm": 29387.3, + "Num Detections": 20142, + "Num Negative": 19622, + "Num Positive": 520, + "Positive %": 2.582, + "Num Positive per mm^2": 201.67 + } +} \ No newline at end of file diff --git a/516/InvasionFront_CD3_block16_x4_y10_patient516_1.json b/516/InvasionFront_CD3_block16_x4_y10_patient516_1.json new file mode 100644 index 0000000000000000000000000000000000000000..334bf86845a9fdb522549e1f45af9e689540d3ab --- /dev/null +++ b/516/InvasionFront_CD3_block16_x4_y10_patient516_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14177.7, + "Centroid Y µm": 29343.1, + "Num Detections": 21050, + "Num Negative": 20598, + "Num Positive": 452, + "Positive %": 2.147, + "Num Positive per mm^2": 188.7 + } +} \ No newline at end of file diff --git a/516/InvasionFront_CD8_block16_x3_y10_patient516_0.json b/516/InvasionFront_CD8_block16_x3_y10_patient516_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5a09ff6e9a4ebd3dc1cb4d1ce39411b68746cf39 --- /dev/null +++ b/516/InvasionFront_CD8_block16_x3_y10_patient516_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10671.8, + "Centroid Y µm": 24486.7, + "Num Detections": 23356, + "Num Negative": 22953, + "Num Positive": 403, + "Positive %": 1.725, + "Num Positive per mm^2": 151.77 + } +} \ No newline at end of file diff --git a/516/InvasionFront_CD8_block16_x4_y10_patient516_1.json b/516/InvasionFront_CD8_block16_x4_y10_patient516_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b711a23f53ad9b8617d68912ffbe135eb9683959 --- /dev/null +++ b/516/InvasionFront_CD8_block16_x4_y10_patient516_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13262.1, + "Centroid Y µm": 24471.6, + "Num Detections": 13936, + "Num Negative": 13599, + "Num Positive": 337, + "Positive %": 2.418, + "Num Positive per mm^2": 206.64 + } +} \ No newline at end of file diff --git a/516/TumorCenter_CD3_block16_x3_y10_patient516_0.json b/516/TumorCenter_CD3_block16_x3_y10_patient516_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5763795abf9686139cdbca649d968f39ad93852f --- /dev/null +++ b/516/TumorCenter_CD3_block16_x3_y10_patient516_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 25536.5, + "Num Detections": 19527, + "Num Negative": 18286, + "Num Positive": 1241, + "Positive %": 6.355, + "Num Positive per mm^2": 503.7 + } +} \ No newline at end of file diff --git a/516/TumorCenter_CD3_block16_x4_y10_patient516_1.json b/516/TumorCenter_CD3_block16_x4_y10_patient516_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ab640ab7a88f8cb2ca38fb08d70e22e32422c3e5 --- /dev/null +++ b/516/TumorCenter_CD3_block16_x4_y10_patient516_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 25611.4, + "Num Detections": 20608, + "Num Negative": 18382, + "Num Positive": 2226, + "Positive %": 10.8, + "Num Positive per mm^2": 833.82 + } +} \ No newline at end of file diff --git a/516/TumorCenter_CD8_block16_x3_y10_patient516_0.json b/516/TumorCenter_CD8_block16_x3_y10_patient516_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6e9a5a893f039375cd27edd487df89e65d3705c0 --- /dev/null +++ b/516/TumorCenter_CD8_block16_x3_y10_patient516_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10769.3, + "Centroid Y µm": 25411.5, + "Num Detections": 19900, + "Num Negative": 19161, + "Num Positive": 739, + "Positive %": 3.714, + "Num Positive per mm^2": 322.51 + } +} \ No newline at end of file diff --git a/516/TumorCenter_CD8_block16_x4_y10_patient516_1.json b/516/TumorCenter_CD8_block16_x4_y10_patient516_1.json new file mode 100644 index 0000000000000000000000000000000000000000..50f2b6e0c6b8c0d379b782ffb1c2430e1963aa9b --- /dev/null +++ b/516/TumorCenter_CD8_block16_x4_y10_patient516_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 25336.6, + "Num Detections": 21204, + "Num Negative": 20425, + "Num Positive": 779, + "Positive %": 3.674, + "Num Positive per mm^2": 299.8 + } +} \ No newline at end of file diff --git a/516/history_text.txt b/516/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/516/icd_codes.txt b/516/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/516/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/516/ops_codes.txt b/516/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..606c9975ff997967a91e53f06bfe9aa19e41bf67 --- /dev/null +++ b/516/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Exzision[5-250.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] \ No newline at end of file diff --git a/516/patient_clinical_data.json b/516/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d977038ab8448209ce9364e346ad33187f833834 --- /dev/null +++ b/516/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 71, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/516/patient_pathological_data.json b/516/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6b056928782e1c543fe03d57ff689b8cb7a5a72a --- /dev/null +++ b/516/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "516", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/516/surgery_description.txt b/516/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d17b19e4b4b9fabfc1910a1d38014a4fd29d983c --- /dev/null +++ b/516/surgery_description.txt @@ -0,0 +1 @@ +Panendo, Exzisionsbiopsie RF i.B. Zungenrand / -rücken diff --git a/516/surgery_report.txt b/516/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..767846c68fc828050e6b44bfafb71d546c06c589 --- /dev/null +++ b/516/surgery_report.txt @@ -0,0 +1 @@ +Patient with .... Leukoplakia left tongue margin, before excision biopsy Performing a panendoscopy. Insertion of the esophagoscope into the stomach. Inconspicuous conditions there. No evidence of a tumor in the area of the esophagus on retraction. Pharyngoscopy: insertion of the Kleinsasser tube. Inconspicuous mucosa can be seen in the area of the piriform sinus on both sides, the postcricoid region, the entrance to the esophagus, the posterior and lateral walls of the oropharynx, the base of the tongue of the vallecula and the lingual epiglottis. Finally, insertion of the rigid tube into the larynx. Performing a microlaryngoscopy: This reveals normal conditions in the area of the entire larynx. Now insertion of a mouth blocker and a tongue retaining suture. Exophytic masses with leukoplakic changes are clearly visible on the left side of the tongue. These are completely cut around with the electric needle, clinically removed in toto, also in the area of the tumor base with a safety margin. The tissue is sent to the pathology department for definitive histology. Finally, hemostasis is performed again with H202 swabs and bipolar coagulation. No more bleeding. End of the procedure. Further procedure: Wait for the definitive histology. Depending on the depth of entry and ultrasound findings, plan neck dissection if necessary. Patient goes to IOI for monitoring due to the pronounced pulmonary artery stenosis. \ No newline at end of file diff --git a/517/InvasionFront_CD3_block3_x5_y6_patient517_0.json b/517/InvasionFront_CD3_block3_x5_y6_patient517_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0a82eb9b0c26965540cc2a23b787f552fc9e664a --- /dev/null +++ b/517/InvasionFront_CD3_block3_x5_y6_patient517_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18015.5, + "Centroid Y µm": 20888.9, + "Num Detections": 22596, + "Num Negative": 19721, + "Num Positive": 2875, + "Positive %": 12.72, + "Num Positive per mm^2": 1231.2 + } +} \ No newline at end of file diff --git a/517/InvasionFront_CD3_block3_x6_y6_patient517_1.json b/517/InvasionFront_CD3_block3_x6_y6_patient517_1.json new file mode 100644 index 0000000000000000000000000000000000000000..32b72f41c30e61b9448b122a45d2b7bfc5403451 --- /dev/null +++ b/517/InvasionFront_CD3_block3_x6_y6_patient517_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20888.9, + "Centroid Y µm": 21238.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/517/InvasionFront_CD8_block3_x5_y6_patient517_0.json b/517/InvasionFront_CD8_block3_x5_y6_patient517_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9e74b0b1bf3e6cdccb5dbea90aa34b2a923f5880 --- /dev/null +++ b/517/InvasionFront_CD8_block3_x5_y6_patient517_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17565.7, + "Centroid Y µm": 14742.2, + "Num Detections": 21856, + "Num Negative": 13653, + "Num Positive": 8203, + "Positive %": 37.53, + "Num Positive per mm^2": 3471.8 + } +} \ No newline at end of file diff --git a/517/InvasionFront_CD8_block3_x6_y6_patient517_1.json b/517/InvasionFront_CD8_block3_x6_y6_patient517_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f257d1073de0773caf598b1ed7c559f79d2ba9de --- /dev/null +++ b/517/InvasionFront_CD8_block3_x6_y6_patient517_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20189.3, + "Centroid Y µm": 14742.2, + "Num Detections": 22582, + "Num Negative": 13609, + "Num Positive": 8973, + "Positive %": 39.74, + "Num Positive per mm^2": 3640.6 + } +} \ No newline at end of file diff --git a/517/TumorCenter_CD3_block3_x5_y6_patient517_0.json b/517/TumorCenter_CD3_block3_x5_y6_patient517_0.json new file mode 100644 index 0000000000000000000000000000000000000000..70f3d910a3401e881fffb8de10c2fb4b5d23a0db --- /dev/null +++ b/517/TumorCenter_CD3_block3_x5_y6_patient517_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16007.5, + "Centroid Y µm": 21451.9, + "Num Detections": 19539, + "Num Negative": 9650, + "Num Positive": 9889, + "Positive %": 50.61, + "Num Positive per mm^2": 4128.7 + } +} \ No newline at end of file diff --git a/517/TumorCenter_CD3_block3_x6_y6_patient517_1.json b/517/TumorCenter_CD3_block3_x6_y6_patient517_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f4ed135a0371d1655d4cff4d5ac6e81529d45df2 --- /dev/null +++ b/517/TumorCenter_CD3_block3_x6_y6_patient517_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18515.2, + "Centroid Y µm": 21438.6, + "Num Detections": 12589, + "Num Negative": 7495, + "Num Positive": 5094, + "Positive %": 40.46, + "Num Positive per mm^2": 3583.0 + } +} \ No newline at end of file diff --git a/517/TumorCenter_CD8_block3_x5_y6_patient517_0.json b/517/TumorCenter_CD8_block3_x5_y6_patient517_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2331cef92a0a7c5f91a7d3555f65ab070a9db62c --- /dev/null +++ b/517/TumorCenter_CD8_block3_x5_y6_patient517_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16916.0, + "Centroid Y µm": 16641.2, + "Num Detections": 21817, + "Num Negative": 8724, + "Num Positive": 13093, + "Positive %": 60.01, + "Num Positive per mm^2": 5160.9 + } +} \ No newline at end of file diff --git a/517/TumorCenter_CD8_block3_x6_y6_patient517_1.json b/517/TumorCenter_CD8_block3_x6_y6_patient517_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6792eb39b39af3ed56cf982a564f47b71b60449d --- /dev/null +++ b/517/TumorCenter_CD8_block3_x6_y6_patient517_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19514.7, + "Centroid Y µm": 16691.2, + "Num Detections": 20273, + "Num Negative": 13304, + "Num Positive": 6969, + "Positive %": 34.38, + "Num Positive per mm^2": 2893.6 + } +} \ No newline at end of file diff --git a/517/history_text.txt b/517/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1c11ddae29245de5706c65e203acdd2305cdcf25 --- /dev/null +++ b/517/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed G3 squamous cell carcinoma of the left hypopharynx. There is also a left cervical level II lymph node conglomerate, so the above-mentioned operation is indicated. \ No newline at end of file diff --git a/517/icd_codes.txt b/517/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7dfd9b3a4db47f58b582a7c407177e3b2fc32dd --- /dev/null +++ b/517/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Regio postcricoidea[C13.0 ] Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] \ No newline at end of file diff --git a/517/ops_codes.txt b/517/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..231f12cea8e7a3c717306871eb74500598dfe3c7 --- /dev/null +++ b/517/ops_codes.txt @@ -0,0 +1 @@ +Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Transorale radikale Resektion des Pharynx [Pharyngektomie] ohne Rekonstruktion[5-296.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Sonstige Temporäre Tracheostomie[5-311.x ] CO2-Lasertechnik[5-985.1 ] \ No newline at end of file diff --git a/517/patient_clinical_data.json b/517/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..641ffcc34f0d35d87b6157d613b58fc1508e013f --- /dev/null +++ b/517/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 182, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/517/patient_pathological_data.json b/517/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c212ae48bd8b5c9aaf4ccf04580c326ef5699d1b --- /dev/null +++ b/517/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "517", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/517/surgery_description.txt b/517/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f0926f448a896a03ceb14f581506f498b0456a6f --- /dev/null +++ b/517/surgery_description.txt @@ -0,0 +1 @@ +Transorale Laserresektion, Neck dissection sowie Tracheotomie diff --git a/517/surgery_report.txt b/517/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1d6b7a46369abcdc19af77b86098af194aa7b4c --- /dev/null +++ b/517/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy: The exophytic tumor is seen, which is located in the area of the hypopharyngeal entrance at the aryepiglottic fold on the right and extends over the anterior wall to the border to the lateral wall, Vallecula is barely reached macroscopically. Initial PEG insertion: insertion of the esophagoscope into the stomach. Once the diaphanoscopy has been performed, a 15 mm stomach wall tube is inserted without complications. Fixation to the abdominal wall in the typical manner. Subsequent transoral laser resection: entering with the spreading laryngoscope. Positioning of the tumor, which is cut around on all sides with a safety margin of at least 1 cm using a 5-pulse CO2 laser. Tumor is resected in toto and is thread-marked for frozen section histology: In the frozen section just towards the base, but in healthy tissue. Carcinoma infiltrates in the cranial area or cranially in the arytenoid fold area. These are subepithelial. Therefore, the cranial area including the vallecula of the lateral epiglottis is resected again. ............................................ here from the cranially adjacent tongue base area to the vallecula. The cranial arytenoid fold was also resected during the resection. Here is another marginal sample supraglottic on the left. The caudal arytenoid fold region is also included again and a frozen section margin sample is taken, which is taken over the arytenoid cartilage. Old marginal samples now in healthy tissue. Therefore, repositioning for neck dissection. First neck dissection on the left: After injecting a total of 10 ml Ultracaine 1 % with adrenaline into both sides of the neck, incision on the left in the typical manner. Exposure of the sternocleidomastoid muscle. Exposure of the digastric muscle. This must be laboriously dissected from a lymph node conglomerate and is partially resected in the process. Exposure of the omohyoid muscle. Visceral development of the lymph node conglomerate in level II. This can be dissected off in toto. The inferior parotid pole can also be removed. Subsequent clearing of level II-V as a whole. Exposure of the internal carotid artery, external carotid artery, superior thyroid artery, internal jugular vein, facial vein. Visualization of vagus nerve, hypoglossal nerve and accessorius nerve. All structures are visualized and preserved. Clearing of the level, also exposing the branches of the cervical plexus. Neck dissection on the right: skin incision in the same way. Evacuation of level II-V in the same way as on the opposite side, but here no suspicious lymph nodes. Exposure and preservation of the structures as on the opposite side. Subsequent careful irrigation of both sides of the neck. Wound closure in layers with insertion of a Redon drain into each side of the neck. Then tracheostoma creation: Small Kocher collar incision, exposure of the thyroid isthmus after splitting the infrahyoid muscles. This is clamped off, severed and supplied by means of puncture ligatures. Presentation of the trachea. Creation of a Björk flap in the 2nd/3rd intercartilaginous space. Epithelialization in a typical manner. Insertion of a laryngectomy tube. At the end of the operation, exchange into size 8 tracheostomy tube. Patient goes to intensive care unit for monitoring after completion of the operation without complications. Continue antibiotic treatment, which was started intraoperatively, for a further 2 days. Nutrition via PEG for approx. 1 week, then carefully build up diet. If necessary, optimize swallowing function by means of swallowing stabilization in the case of extensive mucosal resection in the area of the arytenoid fold with exposed arytenoid cartilage. Wait for the final histology and discuss the findings in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/518/InvasionFront_CD3_block17_x1_y1_patient518_0.json b/518/InvasionFront_CD3_block17_x1_y1_patient518_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c13774121d8cf236a68b828f61fdc31e489c4299 --- /dev/null +++ b/518/InvasionFront_CD3_block17_x1_y1_patient518_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4072.8, + "Centroid Y µm": 7321.1, + "Num Detections": 14296, + "Num Negative": 13747, + "Num Positive": 549, + "Positive %": 3.84, + "Num Positive per mm^2": 372.66 + } +} \ No newline at end of file diff --git a/518/InvasionFront_CD3_block17_x2_y1_patient518_1.json b/518/InvasionFront_CD3_block17_x2_y1_patient518_1.json new file mode 100644 index 0000000000000000000000000000000000000000..46b8906915793bbb9691fae2d28bc8d0b100e3b5 --- /dev/null +++ b/518/InvasionFront_CD3_block17_x2_y1_patient518_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6696.5, + "Centroid Y µm": 7521.0, + "Num Detections": 22391, + "Num Negative": 22175, + "Num Positive": 216, + "Positive %": 0.9647, + "Num Positive per mm^2": 89.33 + } +} \ No newline at end of file diff --git a/518/InvasionFront_CD8_block17_x1_y1_patient518_0.json b/518/InvasionFront_CD8_block17_x1_y1_patient518_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ee6a1978fdc6a4a7379bd4e40d01f9c67401a23 --- /dev/null +++ b/518/InvasionFront_CD8_block17_x1_y1_patient518_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4433.1, + "Centroid Y µm": 2998.5, + "Num Detections": 10553, + "Num Negative": 10305, + "Num Positive": 248, + "Positive %": 2.35, + "Num Positive per mm^2": 210.53 + } +} \ No newline at end of file diff --git a/518/InvasionFront_CD8_block17_x2_y1_patient518_1.json b/518/InvasionFront_CD8_block17_x2_y1_patient518_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a6d6e77ac6982969f33d7132dbf1536fb57d4dd --- /dev/null +++ b/518/InvasionFront_CD8_block17_x2_y1_patient518_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6896.3, + "Centroid Y µm": 2973.4, + "Num Detections": 22263, + "Num Negative": 22216, + "Num Positive": 47, + "Positive %": 0.2111, + "Num Positive per mm^2": 19.62 + } +} \ No newline at end of file diff --git a/518/TumorCenter_CD3_block17_x1_y1_patient518_0.json b/518/TumorCenter_CD3_block17_x1_y1_patient518_0.json new file mode 100644 index 0000000000000000000000000000000000000000..30e027ecb13e6483691c2698ff55f6516cca0a6b --- /dev/null +++ b/518/TumorCenter_CD3_block17_x1_y1_patient518_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3748.0, + "Centroid Y µm": 2648.6, + "Num Detections": 21136, + "Num Negative": 18643, + "Num Positive": 2493, + "Positive %": 11.8, + "Num Positive per mm^2": 1007.4 + } +} \ No newline at end of file diff --git a/518/TumorCenter_CD3_block17_x2_y1_patient518_1.json b/518/TumorCenter_CD3_block17_x2_y1_patient518_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ef30c7492f176d7f1c842b5a2e8733654f2b1960 --- /dev/null +++ b/518/TumorCenter_CD3_block17_x2_y1_patient518_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 2673.6, + "Num Detections": 16886, + "Num Negative": 16576, + "Num Positive": 310, + "Positive %": 1.836, + "Num Positive per mm^2": 144.72 + } +} \ No newline at end of file diff --git a/518/TumorCenter_CD8_block17_x1_y1_patient518_0.json b/518/TumorCenter_CD8_block17_x1_y1_patient518_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cc020c728b6080bc4190b362864abb0bf3f0ad35 --- /dev/null +++ b/518/TumorCenter_CD8_block17_x1_y1_patient518_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6407.7, + "Centroid Y µm": 16487.7, + "Num Detections": 18239, + "Num Negative": 15479, + "Num Positive": 2760, + "Positive %": 15.13, + "Num Positive per mm^2": 1263.8 + } +} \ No newline at end of file diff --git a/518/TumorCenter_CD8_block17_x2_y1_patient518_1.json b/518/TumorCenter_CD8_block17_x2_y1_patient518_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6752908f520aa8a8808bfca74a67f48b6ef425b1 --- /dev/null +++ b/518/TumorCenter_CD8_block17_x2_y1_patient518_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8871.5, + "Centroid Y µm": 16399.7, + "Num Detections": 18291, + "Num Negative": 18192, + "Num Positive": 99, + "Positive %": 0.5412, + "Num Positive per mm^2": 43.45 + } +} \ No newline at end of file diff --git a/518/history_text.txt b/518/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/518/icd_codes.txt b/518/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15cdf3cedbb267117d620058bfef3b6f5d6fd43f --- /dev/null +++ b/518/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/518/ops_codes.txt b/518/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6b46b62883bc8be9f3aee72dcf0e8380b70d6bc3 --- /dev/null +++ b/518/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] \ No newline at end of file diff --git a/518/patient_clinical_data.json b/518/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0e2b4aeb58355aa23b02cdfe17848d950867e609 --- /dev/null +++ b/518/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/518/patient_pathological_data.json b/518/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1d44cf15840eb019d8a15f35acb001c348743b14 --- /dev/null +++ b/518/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "518", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/518/surgery_description.txt b/518/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ff2c9d66aa4feadf33c1a3b7df53df4e3dcba0d1 --- /dev/null +++ b/518/surgery_description.txt @@ -0,0 +1 @@ +MLE, Laserresektion Glottis diff --git a/518/surgery_report.txt b/518/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d5d5fcece7b4191e9219516e5f5ae752f6575b8b --- /dev/null +++ b/518/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia, transoral endotracheal intubation using ........................................... by the anesthesia colleagues and positioning of the patient by the surgeon. Adjustment of the glottic findings using a Kleinsasser tube, revealing an exophytic, contact-vulnerable mass that occupies the entire vocal fold from the anterior commissure to the vocal process of the arytenoid cartilage, although this does not appear to be infiltrated. Adjustment of the findings and subsequent adjustment of the laser beam to a power of 4 watts in continuous mode. First, transverse sectioning of the findings to assess the depth of the tumor. This showed that the tumor did not have a pronounced deep drainage. Subsequently, successive bypassing of the tumor using a laser beam. The tumor can then be removed in 2 parts (piece-meal technique). The following representative margin samples are then taken (cranial left, wound bed, caudal left, anterior commissure). All marginal samples are found to be tumor-free by the pathology colleagues. In the left cranial margin sample. Sparse, low-grade dysplasia was diagnosed, so after consultation with the pathologists, the decision was made to perform a gentle resection. A resection is therefore performed cranially on the left and a second marginal sample is taken at this site. Further resections are sent for final histology. Hemostasis using swabs soaked in Suprarenin. Dry conditions. Completion of the procedure without complications. Please schedule follow-up MLE in 6 weeks. \ No newline at end of file diff --git a/519/InvasionFront_CD3_block19_x1_y9_patient519_0.json b/519/InvasionFront_CD3_block19_x1_y9_patient519_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b75b0638548ae3dfb4ff254a8487f4778744b989 --- /dev/null +++ b/519/InvasionFront_CD3_block19_x1_y9_patient519_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4297.7, + "Centroid Y µm": 24212.2, + "Num Detections": 13626, + "Num Negative": 12782, + "Num Positive": 844, + "Positive %": 6.194, + "Num Positive per mm^2": 519.86 + } +} \ No newline at end of file diff --git a/519/InvasionFront_CD3_block19_x2_y9_patient519_1.json b/519/InvasionFront_CD3_block19_x2_y9_patient519_1.json new file mode 100644 index 0000000000000000000000000000000000000000..40b87b5c5fe198a94558ab7e252824258506b46d --- /dev/null +++ b/519/InvasionFront_CD3_block19_x2_y9_patient519_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 24337.1, + "Num Detections": 15442, + "Num Negative": 15292, + "Num Positive": 150, + "Positive %": 0.9714, + "Num Positive per mm^2": 81.43 + } +} \ No newline at end of file diff --git a/519/InvasionFront_CD8_block19_x1_y9_patient519_0.json b/519/InvasionFront_CD8_block19_x1_y9_patient519_0.json new file mode 100644 index 0000000000000000000000000000000000000000..34206a8269f8890d1975eeac7c48e3ea8e1d841f --- /dev/null +++ b/519/InvasionFront_CD8_block19_x1_y9_patient519_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 32357.9, + "Num Detections": 17866, + "Num Negative": 17832, + "Num Positive": 34, + "Positive %": 0.1903, + "Num Positive per mm^2": 16.68 + } +} \ No newline at end of file diff --git a/519/InvasionFront_CD8_block19_x2_y9_patient519_1.json b/519/InvasionFront_CD8_block19_x2_y9_patient519_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7041adce51f2f75f93bfc97a5e0ba0db16330625 --- /dev/null +++ b/519/InvasionFront_CD8_block19_x2_y9_patient519_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 32282.9, + "Num Detections": 23043, + "Num Negative": 22003, + "Num Positive": 1040, + "Positive %": 4.513, + "Num Positive per mm^2": 424.84 + } +} \ No newline at end of file diff --git a/519/TumorCenter_CD3_block19_x1_y9_patient519_0.json b/519/TumorCenter_CD3_block19_x1_y9_patient519_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c5005bf8acafe1d8b1e3f82efddf2d8ebdcb13f6 --- /dev/null +++ b/519/TumorCenter_CD3_block19_x1_y9_patient519_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5896.9, + "Centroid Y µm": 24686.9, + "Num Detections": 19354, + "Num Negative": 19303, + "Num Positive": 51, + "Positive %": 0.2635, + "Num Positive per mm^2": 22.57 + } +} \ No newline at end of file diff --git a/519/TumorCenter_CD3_block19_x2_y9_patient519_1.json b/519/TumorCenter_CD3_block19_x2_y9_patient519_1.json new file mode 100644 index 0000000000000000000000000000000000000000..51fe712738b07891ba84b2e7ffe7e5859c151411 --- /dev/null +++ b/519/TumorCenter_CD3_block19_x2_y9_patient519_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8370.6, + "Centroid Y µm": 24362.1, + "Num Detections": 12408, + "Num Negative": 12379, + "Num Positive": 29, + "Positive %": 0.2337, + "Num Positive per mm^2": 17.76 + } +} \ No newline at end of file diff --git a/519/TumorCenter_CD8_block19_x1_y9_patient519_0.json b/519/TumorCenter_CD8_block19_x1_y9_patient519_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1a5db6c8fc3507e57c4ac3955144b1d6249a05e1 --- /dev/null +++ b/519/TumorCenter_CD8_block19_x1_y9_patient519_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 33857.1, + "Num Detections": 24248, + "Num Negative": 24131, + "Num Positive": 117, + "Positive %": 0.4825, + "Num Positive per mm^2": 46.5 + } +} \ No newline at end of file diff --git a/519/TumorCenter_CD8_block19_x2_y9_patient519_1.json b/519/TumorCenter_CD8_block19_x2_y9_patient519_1.json new file mode 100644 index 0000000000000000000000000000000000000000..857c6909aa69c3438eeebcbbf0bc8a2b1d8d2402 --- /dev/null +++ b/519/TumorCenter_CD8_block19_x2_y9_patient519_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9245.1, + "Centroid Y µm": 33907.0, + "Num Detections": 17841, + "Num Negative": 17806, + "Num Positive": 35, + "Positive %": 0.1962, + "Num Positive per mm^2": 18.64 + } +} \ No newline at end of file diff --git a/519/history_text.txt b/519/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/519/icd_codes.txt b/519/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/519/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/519/ops_codes.txt b/519/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aed0c7f6f10c141e1e38c32f43f57f3deeef2a21 --- /dev/null +++ b/519/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheotomie[5-312.0 ] Pharyngotomie median transhyoidal[5-290.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/519/patient_clinical_data.json b/519/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5506c6921f5fcdfd869654e4de7d604c0e783cb8 --- /dev/null +++ b/519/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 67, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/519/patient_pathological_data.json b/519/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2b3baa4d2b2a8a85f5abb91d0772d4841daa6fda --- /dev/null +++ b/519/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "519", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 32, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.6", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 19.0 +} \ No newline at end of file diff --git a/519/surgery_description.txt b/519/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..20fde4b7cceac6b861b2417191fb0eaee1f734a3 --- /dev/null +++ b/519/surgery_description.txt @@ -0,0 +1 @@ +Laryngektomie, Neck diss. bds. diff --git a/519/surgery_report.txt b/519/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..354bd5e8fc5de83b8a9eba1c2d06517c23c1c2e8 --- /dev/null +++ b/519/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by anesthesia colleagues. Then intubation by the anesthesia colleagues. Sterile washing and draping. Application of an apron flap in the usual manner. Start with neck dissection on the left side. Exposure of the sternocleidomastoid muscle. Exposure of the digastric and omohyoid muscles. Exposure of the submandibular gland. Exposure of the cervical vascular sheath and clearing of neck levels IIa to Va while sparing the plexus branches. Now switch to the opposite side. Here too, expose the sternocleidomastoid muscle, the omohyoid muscle, the digastric muscle and the submandibular gland. Exposure of the cervical vascular sheath and evacuation of neck levels IIa to Va while sparing the plexus branches. The nervi accessorius and hypoglossus can be spared on both sides and the facial and external veins are also spared on both sides. Then release the larynx, lower the hyoid bone and retract the infrahyoid muscles. Release of the oblique laryngeal muscles. Release of the piriform sinus on both sides. With separation of the upper laryngeal bundle on both sides, entry into the pharynx from the paramedian right. Disluxation of the epiglottis and cutting along the mucosa at the edge of the epiglottis. It is clear that the tumor is mainly located postcricoidally on both sides and extends far into the esophageal entrance. A relatively large amount of mucosa must be removed from the esophageal entrance as it is infiltrated. The larynx is removed below the cricoid cartilage. Marginal samples are taken from the esophageal entrance and from the pharyngeal side walls. All marginal samples are tumor-free in the frozen section. Now insertion of a Provox-Vega prosthesis in the usual manner. Reduction of the insertions of the sternocleidomastoid muscle and performance of a left lateral myotomy on the esophagus. Then two-layer pharyngeal suture in the usual manner. Adaptation of the pharyngeal muscles as far as possible. Then incision of the tracheostoma and two-layer wound closure after insertion of Redon drainage tubes in the usual manner. \ No newline at end of file diff --git a/520/InvasionFront_CD3_block18_x5_y3_patient520_0.json b/520/InvasionFront_CD3_block18_x5_y3_patient520_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5a616658ccb34593243feb66665d867adf310f84 --- /dev/null +++ b/520/InvasionFront_CD3_block18_x5_y3_patient520_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16741.1, + "Centroid Y µm": 12443.4, + "Num Detections": 23022, + "Num Negative": 22963, + "Num Positive": 59, + "Positive %": 0.2563, + "Num Positive per mm^2": 26.44 + } +} \ No newline at end of file diff --git a/520/InvasionFront_CD3_block18_x6_y3_patient520_1.json b/520/InvasionFront_CD3_block18_x6_y3_patient520_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a3a1fa2861859bc02a36b9cd0b439ef5174a370c --- /dev/null +++ b/520/InvasionFront_CD3_block18_x6_y3_patient520_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19364.7, + "Centroid Y µm": 12518.4, + "Num Detections": 24650, + "Num Negative": 23684, + "Num Positive": 966, + "Positive %": 3.919, + "Num Positive per mm^2": 386.25 + } +} \ No newline at end of file diff --git a/520/InvasionFront_CD8_block18_x5_y3_patient520_0.json b/520/InvasionFront_CD8_block18_x5_y3_patient520_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b673abe1b7a28b9d7158f040040588f3fd6e635 --- /dev/null +++ b/520/InvasionFront_CD8_block18_x5_y3_patient520_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16494.5, + "Centroid Y µm": 15615.1, + "Num Detections": 22669, + "Num Negative": 22644, + "Num Positive": 25, + "Positive %": 0.1103, + "Num Positive per mm^2": 10.41 + } +} \ No newline at end of file diff --git a/520/InvasionFront_CD8_block18_x6_y3_patient520_1.json b/520/InvasionFront_CD8_block18_x6_y3_patient520_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e78fb7f2135ed821fdadb7b45666d2d2699bb888 --- /dev/null +++ b/520/InvasionFront_CD8_block18_x6_y3_patient520_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19027.6, + "Centroid Y µm": 15670.5, + "Num Detections": 23315, + "Num Negative": 22677, + "Num Positive": 638, + "Positive %": 2.736, + "Num Positive per mm^2": 258.63 + } +} \ No newline at end of file diff --git a/520/TumorCenter_CD3_block18_x5_y3_patient520_0.json b/520/TumorCenter_CD3_block18_x5_y3_patient520_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ec188bcfc24187980122ca3b3d19caeb778b7b90 --- /dev/null +++ b/520/TumorCenter_CD3_block18_x5_y3_patient520_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15946.5, + "Centroid Y µm": 7519.2, + "Num Detections": 18979, + "Num Negative": 18436, + "Num Positive": 543, + "Positive %": 2.861, + "Num Positive per mm^2": 261.21 + } +} \ No newline at end of file diff --git a/520/TumorCenter_CD3_block18_x6_y3_patient520_1.json b/520/TumorCenter_CD3_block18_x6_y3_patient520_1.json new file mode 100644 index 0000000000000000000000000000000000000000..67838b2381c1b2d034a56ed12e0134badd8c1309 --- /dev/null +++ b/520/TumorCenter_CD3_block18_x6_y3_patient520_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18452.7, + "Centroid Y µm": 7612.9, + "Num Detections": 18885, + "Num Negative": 18816, + "Num Positive": 69, + "Positive %": 0.3654, + "Num Positive per mm^2": 29.2 + } +} \ No newline at end of file diff --git a/520/TumorCenter_CD8_block18_x5_y3_patient520_0.json b/520/TumorCenter_CD8_block18_x5_y3_patient520_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d5200c137a42aecd19264c3a0228ed89e8619a1 --- /dev/null +++ b/520/TumorCenter_CD8_block18_x5_y3_patient520_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 8120.7, + "Num Detections": 21056, + "Num Negative": 20541, + "Num Positive": 515, + "Positive %": 2.446, + "Num Positive per mm^2": 233.41 + } +} \ No newline at end of file diff --git a/520/TumorCenter_CD8_block18_x6_y3_patient520_1.json b/520/TumorCenter_CD8_block18_x6_y3_patient520_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e736a685e9cbf482582af1de89fa16dc6b6a15ba --- /dev/null +++ b/520/TumorCenter_CD8_block18_x6_y3_patient520_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 8145.7, + "Num Detections": 24278, + "Num Negative": 24146, + "Num Positive": 132, + "Positive %": 0.5437, + "Num Positive per mm^2": 54.68 + } +} \ No newline at end of file diff --git a/520/history_text.txt b/520/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7e5265682bb0dbac2344d5d8505e0cb5db08178c --- /dev/null +++ b/520/history_text.txt @@ -0,0 +1 @@ +After histological confirmation of a cT1a glottic laryngeal carcinoma on the left side. There is now an indication for tumor resection. Primary attempt from transoral. Due to the lack of adjustability and the localization in the area of the anterior commissure, an external approach was also discussed with the patient preoperatively. The patient had ample opportunity to ask questions about the explained procedure preoperatively. \ No newline at end of file diff --git a/520/icd_codes.txt b/520/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b8056349bf7d1f1a5acc73d65b6b09b6b4e86af --- /dev/null +++ b/520/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 B] \ No newline at end of file diff --git a/520/ops_codes.txt b/520/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..52ec08412cae6c051c02a2456bf51527a4a524dc --- /dev/null +++ b/520/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] \ No newline at end of file diff --git a/520/patient_clinical_data.json b/520/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..da508efd557461dc07b6b7cd259cf465d94b888c --- /dev/null +++ b/520/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 6, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/520/patient_pathological_data.json b/520/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ea38cdf051429ada2df54377678e6bf042d380f2 --- /dev/null +++ b/520/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "520", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/520/surgery_description.txt b/520/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1537aa88378fdcf56f3adee326d647f4bc361225 --- /dev/null +++ b/520/surgery_description.txt @@ -0,0 +1 @@ +KK-Teilresektion, MLE diff --git a/520/surgery_report.txt b/520/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..88d1e717122823b04bb2df74d853a6b5851d8b95 --- /dev/null +++ b/520/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carrying out the team time-out. Introductory consultation with the anesthesia department. Induction of anesthesia and intubation of the patient. Positioning of the patient by the surgeon. Insertion of the mouth guard. Insertion of the size D small bore tube. The tumor is now inspected with the aid of the support autoscope and the surgical microscope. Even after several attempts, the anterior commissure can only be visualized insufficiently. The decision is therefore made to access the tumor from the outside. Removal of the small bore tube. Positioning of the patient in head reclination. Skin spray disinfection and infiltration anesthesia. Skin wipe disinfection and sterile draping. First mark the thyroid incision. Marking of the planned incision using the broken-line technique. Sharp cutting of the cutis as well as the subcutis. Insert the retractors. Exposure of the prelaryngeal musculature. Locating the midline and lateralizing the musculature. Exposure of the thyroid cartilage and the ligamentum conicum. Incision of the perichondrium in the median line using the 15 mm scalpel. Creation of a horizontal incision in the area of the ligamentum conicum. Prepare two perichondrium flaps and also knock them aside. Opening of the larynx in the sense of a thyrofissure using the wheel. Insertion of the two-pronged retractor. A tumor is found in the area of the anterior and middle third of the left vocal fold. This reaches the anterior commissure. Incision of the tumor area with the 15 mm scalpel and removal of various marginal samples. During the intraoperative frozen section, tumor, i.e. carcinoma infiltrates, are still visible supraglottically on the left. In the cranial, caudal and supraglottic right margin samples, extensions of a carcinoma in situ are still visible. Therefore indication for resection and submission of new margin samples. These are now found to be tumor-free in the frozen section diagnostics. The extent of the resection therefore extended from the anterior commissure via the vocal ligament, vocal muscle and thyroarytaenoid muscle to just before the vocal process. Due to the extent of the tumor, the inner cortex of the thyroid cartilage is now cut with the diamond drill. Hemostasis by insertion of a suprarenin-soaked strip. This is followed by punctual hemostasis using bipolar coagulation. Persistent dry wound bed at the end of the operation. Insertion of a 14-gauge wedge. Drilling of a total of four holes. Fixation of the wedge with Vicryl 3-0, followed by knocking back the neatly prepared perichondrium flaps and complete covering of the previously inserted wedge. In addition, readaptation of the previously mobilized prelaryngeal muscles. Prior to this, the wound is irrigated with H2O2 and Ringer's solution. Insertion of a sterile flap. Subcutaneous suture with Vicryl 4-0 and skin suture with Ethilon 5-0. Application of a wound dressing and a pressure bandage. Completion of the operation without complications. Final consultation with the anesthesiologist. Note: The patient should be scheduled for a control MLE, if necessary with removal of the cone, in approx. 6 weeks postoperatively. \ No newline at end of file diff --git a/521/InvasionFront_CD3_block13_x1_y8_patient521_0.json b/521/InvasionFront_CD3_block13_x1_y8_patient521_0.json new file mode 100644 index 0000000000000000000000000000000000000000..20131b4eebff62704f32ab743d9d296df22ab013 --- /dev/null +++ b/521/InvasionFront_CD3_block13_x1_y8_patient521_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.1, + "Centroid Y µm": 19064.9, + "Num Detections": 18633, + "Num Negative": 18115, + "Num Positive": 518, + "Positive %": 2.78, + "Num Positive per mm^2": 200.02 + } +} \ No newline at end of file diff --git a/521/InvasionFront_CD3_block13_x2_y8_patient521_1.json b/521/InvasionFront_CD3_block13_x2_y8_patient521_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7b5f88574902cdbf6a7bc3383032efd07d05cd81 --- /dev/null +++ b/521/InvasionFront_CD3_block13_x2_y8_patient521_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 19089.9, + "Num Detections": 19640, + "Num Negative": 18406, + "Num Positive": 1234, + "Positive %": 6.283, + "Num Positive per mm^2": 493.86 + } +} \ No newline at end of file diff --git a/521/InvasionFront_CD8_block13_x1_y8_patient521_0.json b/521/InvasionFront_CD8_block13_x1_y8_patient521_0.json new file mode 100644 index 0000000000000000000000000000000000000000..73e0c5e26495f8e5a5d57e70057edd934f6142c6 --- /dev/null +++ b/521/InvasionFront_CD8_block13_x1_y8_patient521_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4322.7, + "Centroid Y µm": 20489.2, + "Num Detections": 21716, + "Num Negative": 20816, + "Num Positive": 900, + "Positive %": 4.144, + "Num Positive per mm^2": 333.83 + } +} \ No newline at end of file diff --git a/521/InvasionFront_CD8_block13_x2_y8_patient521_1.json b/521/InvasionFront_CD8_block13_x2_y8_patient521_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ad95a705de263d98c7cda74ff77547cb02a0508d --- /dev/null +++ b/521/InvasionFront_CD8_block13_x2_y8_patient521_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6996.3, + "Centroid Y µm": 20589.1, + "Num Detections": 21759, + "Num Negative": 20136, + "Num Positive": 1623, + "Positive %": 7.459, + "Num Positive per mm^2": 625.66 + } +} \ No newline at end of file diff --git a/521/TumorCenter_CD3_block13_x1_y8_patient521_0.json b/521/TumorCenter_CD3_block13_x1_y8_patient521_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a0e7dc79f103e5894c5254540a741b27533ebffd --- /dev/null +++ b/521/TumorCenter_CD3_block13_x1_y8_patient521_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 25861.3, + "Num Detections": 8580, + "Num Negative": 8223, + "Num Positive": 357, + "Positive %": 4.161, + "Num Positive per mm^2": 350.79 + } +} \ No newline at end of file diff --git a/521/TumorCenter_CD3_block13_x2_y8_patient521_1.json b/521/TumorCenter_CD3_block13_x2_y8_patient521_1.json new file mode 100644 index 0000000000000000000000000000000000000000..81aaf37eec5439dfdf902a5a3f9971f5c24338d0 --- /dev/null +++ b/521/TumorCenter_CD3_block13_x2_y8_patient521_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6846.4, + "Centroid Y µm": 25961.3, + "Num Detections": 13412, + "Num Negative": 11568, + "Num Positive": 1844, + "Positive %": 13.75, + "Num Positive per mm^2": 1007.7 + } +} \ No newline at end of file diff --git a/521/TumorCenter_CD8_block13_x1_y8_patient521_0.json b/521/TumorCenter_CD8_block13_x1_y8_patient521_0.json new file mode 100644 index 0000000000000000000000000000000000000000..64a408821a4f4ebb15c9dd0c26b768dcf0081bf1 --- /dev/null +++ b/521/TumorCenter_CD8_block13_x1_y8_patient521_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5247.2, + "Centroid Y µm": 20814.0, + "Num Detections": 19616, + "Num Negative": 19537, + "Num Positive": 79, + "Positive %": 0.4027, + "Num Positive per mm^2": 34.05 + } +} \ No newline at end of file diff --git a/521/TumorCenter_CD8_block13_x2_y8_patient521_1.json b/521/TumorCenter_CD8_block13_x2_y8_patient521_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d50f05dc3a4c50a67f741cca4b290f3a0c382ee9 --- /dev/null +++ b/521/TumorCenter_CD8_block13_x2_y8_patient521_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7870.8, + "Centroid Y µm": 20439.2, + "Num Detections": 12774, + "Num Negative": 11816, + "Num Positive": 958, + "Positive %": 7.5, + "Num Positive per mm^2": 580.39 + } +} \ No newline at end of file diff --git a/521/history_text.txt b/521/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..866bff9ee0da4f3c972cb2be96102b8676dc9130 --- /dev/null +++ b/521/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed G3 squamous cell carcinoma of the tongue margin and tongue body on the left without crossing the midline, suspicious cervical lymph nodes on both sides. Therefore, the above-mentioned surgery is now indicated. Patient also informed about the necessity of flap coverage due to the extent of the tumor. \ No newline at end of file diff --git a/521/icd_codes.txt b/521/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..22d10572fc7d8a5e7a15c33b5b31b6bfc7923dde --- /dev/null +++ b/521/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/521/ops_codes.txt b/521/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a1402e89beb5257584a67787110b554b4b3e657 --- /dev/null +++ b/521/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Transorale Hemiglossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme freier Radialis-Lappen[5-858.23 L] Temporäre Tracheotomie[5-311.0 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] \ No newline at end of file diff --git a/521/patient_clinical_data.json b/521/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d0c34eaefc4a25c377bd2495d4b2898b116dbc69 --- /dev/null +++ b/521/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 37, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 6, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/521/patient_pathological_data.json b/521/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1e08cb1a82d7dd8370f1aabe86ce339eb7e7cff6 --- /dev/null +++ b/521/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "521", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/521/surgery_description.txt b/521/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..cf6ef9936ff8a9ed2457cdb49725062ed9962e03 --- /dev/null +++ b/521/surgery_description.txt @@ -0,0 +1 @@ +Resektion, Neck diss. (Lvl. I-V) bds., PEG- u. Tracheostoma-Anlage, Defektdeckung (Radialis) diff --git a/521/surgery_report.txt b/521/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a997d698d24c38bce31cd822793bc6f3977e7495 --- /dev/null +++ b/521/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again: The exulcerated tumor is seen in the area of the edge and body of the tongue on the right, the tip of the tongue is recessed, palpation extends into the base of the tongue, does not cross the midline and merges slightly into the floor of the mouth. Overall, indication for the above-mentioned operation with flap coverage confirmed. Initial PEG insertion: Pre-mirroring with the gastroesophagoscope and insertion of the PEG tube using the thread pull-through method after a clear positive diaphanoscopy. No complications. Subsequent transoral tumor resection: insertion of Spandex, followed by insertion of a retractor to open the mouth. Snaring of the tongue. Subsequent resection of the tumor with a safety margin of at least 1.5 cm macroscopically to 2 cm macroscopically on all sides. The right half of the tongue is removed, leaving out the most anterior parts of the tip of the tongue. Resection is performed next to the left raphe. Resection encompasses the floor of the mouth up to the alveolar ridge, taking all soft tissue down to the bone. The lingual nerve cannot be spared here and is also resected, as are parts of the sublingual gland and submandibular gland. Resection extends to the base of the tongue. The resection extends from the alveolar ridge over the anterior palatal arch to the right tonsil, which is also taken along with the anterior palatal arch. The specimen is then removed in toto and marked with sutures. It goes to the frozen section examination. In addition, the submandibular gland with attached soft tissue is removed transcervically and an extensive resection or marginal sample is taken from the soft tissue basally at the transition to the neck on the right. In combination with the main tumor and marginal samples, this results in an R0 situation. Subsequent careful hemostasis. Measure the size of the flap, which is approx. 12 x 8 cm. Drawing in three-dimensional requirements on the left forearm. Neck dissection on the left by /: Incision on the anterior edge of the sternocleidomastoid muscle between the mastoid and 2 transverse fingers above the clavicle using a 10 mm scalpel. Sharp cutting of the skin, subcutaneous tissue, platysma. Ligation and transection of the external jugular vein. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid, digaster and submandibular gland on the left. Exposure of the accessorius nerve, which shows an anastomosis to the cervical plexus. The internal jugular vein, hypoglossal nerve, common carotid artery and vagus nerve are now also visualized and the neck preparation is successively replaced, starting with level II up to level V b. Macroscopically, several metastases requiring partial removal of the cervical plexus. The accessor nerve remains intact as well as the anastomosis to the cervical plexus. Level V b is also completely removed. No chyle fistula. Punctual hemostasis. Insertion of a 10-gauge Redon drain and two-layer wound closure using 3.0 Vicryl and 4.0 Ethilon. Neck dissection on the right by : Incision on the anterior edge of the sternocleidomastoid muscle between the mastoid and 2 transverse fingers above the clavicle using a 10 mm scalpel. Sharp cutting of the skin, subcutaneous tissue, platysma. Ligation and transection of the external jugular vein. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, the V. post of the digaster muscle and the left submandibular gland. Visualization of the accessorius nerve, which shows an anastomosis to the cervical plexus. Macroscopically, there are several metastatic masses. The largest in level II on the jugulofacial angle. This is successively replaced by the VJI and the facial vein. The hypoglossal nerve and the two veins can be spared. The common carotid artery and vagus nerve are now also visualized and the neck preparation is successively detached starting with level II up to level Vb. The accessory nerve remains intact as well as the anastomosis to the cervical plexus. Level V b is also completely removed. No evidence of chyle fistula. Punctual hemostasis using bipolar coagulation. Submadibulectomy and removal of the lymph nodes of level Ib in toto. Now transection of the digastric muscle V. postior and breakthrough enorally. Exposure of the superior thyroid artery, the lingual artery and the facial artery as possible connecting vessels. Elevation of the radial forearm flap on the left by and : Palpatory identification of the distal radial artery. Marking of the flap borders (12 x 7 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the pronator quadratus and flexor pollicis longus muscles with ligation of the outgoing perforators using a vascular clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Removal of split skin from the right thigh and two-layer closure of the left forearm by . Then suturing of the flap. The flap is sutured successively, partly with the sutures in place, and the pedicle is pulled through in between. It can be seen that the flap can be sutured into the defect correctly in three dimensions without tension and without any problems. Subsequent vascular anastomoses. The radial artery is anastomosed with the superior thyroid artery after vessel conditioning using 9.0 Ethilon single-button sutures. After conditioning of a thyroid vein and a facial vein, the vein is sutured with 3.0 and 2.5 mm couplers in the typical manner. In each case after opening the clamps, smear phenomenon positive and good venous return, also good arterial flow. Subsequent careful irrigation. Layered closure of the neck wound on the right with insertion of 2 flaps and on the left with insertion of a Redon drain. Finally, tracheostoma placement by : skin incision and dissection through the subcutaneous fatty tissue. Dissection along the linea alba in depth. Push the infrahyoid muscles to the side. Exposure of the thyroid gland and ligation of the V. jugularis ant. Untermination and transection of the thyroid gland. Exposure of the front of the trachea. Insertion between the 2nd and 3rd tracheal clasp in the form of a visor tracheotomy. Suturing in the usual manner. Thorough inspection of the flap. This is well supplied with blood. The procedure is then completed without complications. Patient goes to the intensive care unit for monitoring. Flap control routinely for 5 days by means of enoral inspection. Postoperative continuation of antibiotics as already started preoperatively with Unacid i.v., feeding via the inserted PEG tube for 10-12 days, then gruel swallowing and, if necessary, diet build-up. Overall cT3 cN2c tongue carcinoma or oropharyngeal carcinoma on the right. Awaiting final histology and discussion of further procedure in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/522/InvasionFront_CD3_block8_x1_y8_patient522_0.json b/522/InvasionFront_CD3_block8_x1_y8_patient522_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2c3b49c980b20ad70b473b4a5ab0f7db2526ce42 --- /dev/null +++ b/522/InvasionFront_CD3_block8_x1_y8_patient522_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 30633.8, + "Num Detections": 27467, + "Num Negative": 20615, + "Num Positive": 6852, + "Positive %": 24.95, + "Num Positive per mm^2": 2568.2 + } +} \ No newline at end of file diff --git a/522/InvasionFront_CD3_block8_x2_y8_patient522_1.json b/522/InvasionFront_CD3_block8_x2_y8_patient522_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5f431e3dd858ac94a715f5296209a478c300298d --- /dev/null +++ b/522/InvasionFront_CD3_block8_x2_y8_patient522_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6171.7, + "Centroid Y µm": 30433.9, + "Num Detections": 19050, + "Num Negative": 17285, + "Num Positive": 1765, + "Positive %": 9.265, + "Num Positive per mm^2": 797.69 + } +} \ No newline at end of file diff --git a/522/InvasionFront_CD8_block8_x1_y8_patient522_0.json b/522/InvasionFront_CD8_block8_x1_y8_patient522_0.json new file mode 100644 index 0000000000000000000000000000000000000000..738b52b52942bcc42e64dc6b34ca39b5ba2d8714 --- /dev/null +++ b/522/InvasionFront_CD8_block8_x1_y8_patient522_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3748.0, + "Centroid Y µm": 19989.4, + "Num Detections": 33355, + "Num Negative": 30857, + "Num Positive": 2498, + "Positive %": 7.489, + "Num Positive per mm^2": 939.81 + } +} \ No newline at end of file diff --git a/522/InvasionFront_CD8_block8_x2_y8_patient522_1.json b/522/InvasionFront_CD8_block8_x2_y8_patient522_1.json new file mode 100644 index 0000000000000000000000000000000000000000..33c3ea9ac9e5439c61ac1d4399b31ff2fd4d90c6 --- /dev/null +++ b/522/InvasionFront_CD8_block8_x2_y8_patient522_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 19989.4, + "Num Detections": 21667, + "Num Negative": 20944, + "Num Positive": 723, + "Positive %": 3.337, + "Num Positive per mm^2": 309.19 + } +} \ No newline at end of file diff --git a/522/TumorCenter_CD3_block8_x1_y8_patient522_0.json b/522/TumorCenter_CD3_block8_x1_y8_patient522_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cceb4c537d1d602f2e7aa625e65e171b91ad79f5 --- /dev/null +++ b/522/TumorCenter_CD3_block8_x1_y8_patient522_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5247.2, + "Centroid Y µm": 21688.5, + "Num Detections": 12831, + "Num Negative": 11257, + "Num Positive": 1574, + "Positive %": 12.27, + "Num Positive per mm^2": 1079.4 + } +} \ No newline at end of file diff --git a/522/TumorCenter_CD3_block8_x2_y8_patient522_1.json b/522/TumorCenter_CD3_block8_x2_y8_patient522_1.json new file mode 100644 index 0000000000000000000000000000000000000000..903d238027684c17ed739acf08d808a55587a24f --- /dev/null +++ b/522/TumorCenter_CD3_block8_x2_y8_patient522_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7845.8, + "Centroid Y µm": 21488.6, + "Num Detections": 4461, + "Num Negative": 4014, + "Num Positive": 447, + "Positive %": 10.02, + "Num Positive per mm^2": 901.39 + } +} \ No newline at end of file diff --git a/522/TumorCenter_CD8_block8_x1_y8_patient522_0.json b/522/TumorCenter_CD8_block8_x1_y8_patient522_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a0e4305bfca66a05c57e4cc0a72f40e4fcdce45 --- /dev/null +++ b/522/TumorCenter_CD8_block8_x1_y8_patient522_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4622.6, + "Centroid Y µm": 21063.8, + "Num Detections": 24330, + "Num Negative": 24003, + "Num Positive": 327, + "Positive %": 1.344, + "Num Positive per mm^2": 127.69 + } +} \ No newline at end of file diff --git a/522/TumorCenter_CD8_block8_x2_y8_patient522_1.json b/522/TumorCenter_CD8_block8_x2_y8_patient522_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6aef785d7183bc428e0600af3579449566d998a8 --- /dev/null +++ b/522/TumorCenter_CD8_block8_x2_y8_patient522_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7221.2, + "Centroid Y µm": 20789.0, + "Num Detections": 17942, + "Num Negative": 16566, + "Num Positive": 1376, + "Positive %": 7.669, + "Num Positive per mm^2": 695.59 + } +} \ No newline at end of file diff --git a/522/history_text.txt b/522/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a954f5b1068e5ee974b6fcd4e65a65e8f2e3bcbc --- /dev/null +++ b/522/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the oropharynx on the right. Tumor sits relatively flat on the anterior palatal arch, runs over the alveolar ridge onto the glossoalveolar groove, from there to just below the base of the tongue over the tonsillar lobe. The above-mentioned surgery was therefore indicated. The patient was also informed about covering the defect with a radial flap if necessary. \ No newline at end of file diff --git a/522/icd_codes.txt b/522/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2371a56b285c2bf53d9fdf895db4fbc8e7082378 --- /dev/null +++ b/522/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Fossa tonsillaris[C09.0 ] Tonsillenkarzinom[C09.9 ] Bösartige Neubildung Lippe Mundhöhle Pharynx mehrere Teilbereiche überlappend[C14.8 ] \ No newline at end of file diff --git a/522/ops_codes.txt b/522/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..737d5294270e3c7a3ba8420b1ba48b38e36975cf --- /dev/null +++ b/522/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Permanente Tracheostomaanlage[5-312.0 ] Tonsillektomie radikal transoral[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte Hypopharyngoskopie[1-611.0 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.x1 ] \ No newline at end of file diff --git a/522/patient_clinical_data.json b/522/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a6fbf2294bf1f3cd97b27632177410b9aa6aa85d --- /dev/null +++ b/522/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 48, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 16, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/522/patient_pathological_data.json b/522/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2f36ff68f745000ba728725666c52c3af85b4f75 --- /dev/null +++ b/522/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "522", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 58, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/522/surgery_description.txt b/522/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d7d26673a2d75cde5f92b59959db04a0f73ec75d --- /dev/null +++ b/522/surgery_description.txt @@ -0,0 +1 @@ +Resektion, Neck dissection sowie PEG-Anlage diff --git a/522/surgery_report.txt b/522/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..47c11e1890b065c8290b73b707d1cfa05d730091 --- /dev/null +++ b/522/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again. The tumor is found as described. This is followed by flexible esophagoscopy and, after the diaphanoscopy has been performed, a 15 mm abdominal wall probe is inserted in a typical manner without complications. Fixation of an abdominal wall in a typical manner. Then transoral resection. Tumor is incised on all sides with a safety margin of 0.5 to 1 cm and excised with relatively flat growth, especially in the palatal arch area, so that the underlying musculature is largely preserved. Resection via the alveolar ridge, preserving tissue on the bone. Resection goes over the glosso-alveolar groove down to the base of the tongue. In the area of the oropharyngeal side wall, removal of the tonsil and the outermost parts of the posterior palatal arch. Resection up to the beginning of the posterior pharyngeal wall. Resection also including the most lateral parts of the base of the tongue. Suture is thread-marked for histology. Preparation basally in healthy tissue, also laterally. Infiltrates still in situ in the area of the posterior pharyngeal wall and the beginning of the posterior palatal arch. No infiltrates caudally. ............................. not cranially. The additional margin sample inserted laterally over the alveolar ridge and the glosso-tonsillar groove was healthy. This is followed by a resection approx. 1 cm wide, which extends from the middle area of the posterior palatal arch over the beginning of the posterior wall of the pharynx to the entrance of the hypopharynx. This extends cranially and caudally with a suture mark and remote from the tumor to the frozen section. Here in the middle area still in situ infiltrates, cranially and completely caudally free. Therefore, another resection from the same area, again at least 1 cm thick, which extends to the hypopharyngeal entrance. Now in the cranial and middle area still at least medium grade dysplasia, possibly already transition to higher grade dysplasia, in the caudal area now in situ. Therefore overall suspected field carcinomatization. A strip of mucosa is again removed from the mid to caudal area extending to the hypopharyngeal entrance. This is again thread-marked, but this time for final histology. Careful hemostasis. Termination of the procedure at this point. Overall, field carcinomatization. Now transfer to neck dissection: First neck dissection on the right: skin incision in typical manner. Exposure of the sternocleidomastoid muscle. Depiction of the omohyoid muscle, depiction of the digastric muscle. Exposure of the cervical vascular sheath, internal jugular vein, internal carotid artery, external carotid artery, facial vein, superior thyroid artery. Exposure of vagus nerve, accessorius nerve, hypoglossal nerve. Successive removal of the lateral neck preparation while exposing and preserving the branches of the cervical plexus. Subsequent removal of the anterior neck preparation. The overall result is a level II-V removal. Clearly suspicious lymph nodes, at least 1-2, particularly in the Level II cranial region, followed by neck dissection on the left side. This is done in the same way as on the right side. The result is a level II-IV evacuation. Here too, at least clinically suspicious lymph nodes on the cranial side. Subsequently, careful hemostasis, irrigation of the wound area with H202 and Ringer's solution. Wound closure in layers and insertion of a Redon drain in each side of the neck. Then, in the case of an extensive defect, enoral decision to perform a tracheotomy in the sense of a protective tracheostomy. Small Kocher collar incision. Dissection through the subcutaneous tissue to the infrahyoid musculature. Splitting of these in the area of the.............................. Exposure of the thyroid isthmus. Undercutting this. Clamping, severing and supplying by means of puncture ligatures. Subsequent insertion into the 2nd/3rd intercartilaginous space. Creation of a wide pedicled Björk flap. This is successively epithelized in the typical manner. Subsequently insertion of an 8 mm tracheal cannula. Check again enorally. No signs of bleeding. Completion of the procedure without complications. Overall cT2-3 oropharyngeal carcinoma. Due to the extensive and discontinuous growth, suspected field cancerization. Last resection sent in for final margin sample. Overall indication for radiotherapy in the pharyngeal region, possibly radiochemotherapy depending on the lymph node findings. The patient is admitted to the intensive care unit for postoperative monitoring. Please continue antibiotics for 2-3 days. Nutrition for at least 1 week via the inserted PEG tube. Possibly postoperative swallowing training in the case of extensive mucosal defects, also in the posterior wall area. \ No newline at end of file diff --git a/523/InvasionFront_CD3_block7_x5_y6_patient523_0.json b/523/InvasionFront_CD3_block7_x5_y6_patient523_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e0bf4a56ab1fc5f4c69cc99f78b1da56c075457c --- /dev/null +++ b/523/InvasionFront_CD3_block7_x5_y6_patient523_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16525.7, + "Centroid Y µm": 14601.6, + "Num Detections": 11156, + "Num Negative": 10596, + "Num Positive": 560, + "Positive %": 5.02, + "Num Positive per mm^2": 329.08 + } +} \ No newline at end of file diff --git a/523/InvasionFront_CD3_block7_x6_y6_patient523_1.json b/523/InvasionFront_CD3_block7_x6_y6_patient523_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0c0635680ac03364bee37fdfb45cc5417b3b35fb --- /dev/null +++ b/523/InvasionFront_CD3_block7_x6_y6_patient523_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 14579.8, + "Num Detections": 17226, + "Num Negative": 16856, + "Num Positive": 370, + "Positive %": 2.148, + "Num Positive per mm^2": 200.72 + } +} \ No newline at end of file diff --git a/523/InvasionFront_CD8_block7_x5_y6_patient523_0.json b/523/InvasionFront_CD8_block7_x5_y6_patient523_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a2491a1e3e8fbdf2003e20511623fabbba8fd18 --- /dev/null +++ b/523/InvasionFront_CD8_block7_x5_y6_patient523_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17408.7, + "Centroid Y µm": 16080.3, + "Num Detections": 9937, + "Num Negative": 9715, + "Num Positive": 222, + "Positive %": 2.234, + "Num Positive per mm^2": 133.99 + } +} \ No newline at end of file diff --git a/523/InvasionFront_CD8_block7_x6_y6_patient523_1.json b/523/InvasionFront_CD8_block7_x6_y6_patient523_1.json new file mode 100644 index 0000000000000000000000000000000000000000..37d4fafe7d619d8d7f89d0d146ed0fae35ca17de --- /dev/null +++ b/523/InvasionFront_CD8_block7_x6_y6_patient523_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19977.9, + "Centroid Y µm": 16346.2, + "Num Detections": 14411, + "Num Negative": 14188, + "Num Positive": 223, + "Positive %": 1.547, + "Num Positive per mm^2": 131.41 + } +} \ No newline at end of file diff --git a/523/TumorCenter_CD3_block7_x5_y6_patient523_0.json b/523/TumorCenter_CD3_block7_x5_y6_patient523_0.json new file mode 100644 index 0000000000000000000000000000000000000000..31512ace80dea9aac6a7a26c85360dc8109100f5 --- /dev/null +++ b/523/TumorCenter_CD3_block7_x5_y6_patient523_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 15341.9, + "Num Detections": 11811, + "Num Negative": 11331, + "Num Positive": 480, + "Positive %": 4.064, + "Num Positive per mm^2": 314.27 + } +} \ No newline at end of file diff --git a/523/TumorCenter_CD3_block7_x6_y6_patient523_1.json b/523/TumorCenter_CD3_block7_x6_y6_patient523_1.json new file mode 100644 index 0000000000000000000000000000000000000000..91119f77ca7074ed40ad211c4648f6585d0c9e84 --- /dev/null +++ b/523/TumorCenter_CD3_block7_x6_y6_patient523_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 15266.9, + "Num Detections": 16461, + "Num Negative": 15589, + "Num Positive": 872, + "Positive %": 5.297, + "Num Positive per mm^2": 404.04 + } +} \ No newline at end of file diff --git a/523/TumorCenter_CD8_block7_x5_y6_patient523_0.json b/523/TumorCenter_CD8_block7_x5_y6_patient523_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cf51b0333b86bba0a0b5c341cef2d56756ad8b34 --- /dev/null +++ b/523/TumorCenter_CD8_block7_x5_y6_patient523_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15816.6, + "Centroid Y µm": 15167.0, + "Num Detections": 12764, + "Num Negative": 12611, + "Num Positive": 153, + "Positive %": 1.199, + "Num Positive per mm^2": 99.39 + } +} \ No newline at end of file diff --git a/523/TumorCenter_CD8_block7_x6_y6_patient523_1.json b/523/TumorCenter_CD8_block7_x6_y6_patient523_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1592ecb26b448eddc0cfa6943422bdf21778681a --- /dev/null +++ b/523/TumorCenter_CD8_block7_x6_y6_patient523_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 15216.9, + "Num Detections": 18496, + "Num Negative": 18282, + "Num Positive": 214, + "Positive %": 1.157, + "Num Positive per mm^2": 95.89 + } +} \ No newline at end of file diff --git a/523/history_text.txt b/523/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/523/icd_codes.txt b/523/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45d2eca409f9787902f5bba4aeda97ed19776348 --- /dev/null +++ b/523/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/523/ops_codes.txt b/523/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fba3c13ae0b617ab995da3ce12d88b2536f36fbb --- /dev/null +++ b/523/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.14 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] PEG-Sonde Anlage[5-431.2 ] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Permanente Tracheotomie[5-312.0 ] Entnahme Spalthaut zur Transplantation Unterarm[5-901.08 R] Entnahme freier Radialis-Lappen[5-858.23 L] \ No newline at end of file diff --git a/523/patient_clinical_data.json b/523/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ff9543700e9d17922537ef60ca01e6762aa499cc --- /dev/null +++ b/523/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 41, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/523/patient_pathological_data.json b/523/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dcc2b0c96d651271e8828cbfc75842a2c71aa753 --- /dev/null +++ b/523/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "523", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/523/surgery_description.txt b/523/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e261b31b9d44c82c1b7a7707907e858b510d4988 --- /dev/null +++ b/523/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion, ND bds., Freier Lappen (Radialis), Tracheotomie, PEG-Anlage diff --git a/523/surgery_report.txt b/523/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..16b0d81034ac42bea407610d415a152b865aeb2f --- /dev/null +++ b/523/surgery_report.txt @@ -0,0 +1 @@ +Dictation : After induction of anesthesia and intubation by the anesthesia colleagues, the primary tumor area is first inspected using the Kleinsasser tube under dental protection. An exophytic tumor process with infiltration of the epiglottis can be seen starting at the free edge of the epiglottis on the right. The tumor continues across the aryepiglottic fold to just before the ary, a satellite focus is located slightly distant on the arytenoid mucosa, the main tumor mass is located in the right piriform sinus, which is subtotally filled, but the tip of the piriform sinus and the transition to the posterior wall of the hypopharynx are again tumor-free. Overall, there are clear perifocal extensions with a clearly uneven mucosa. Due to the extent, extensive cT2 with confirmed epiglottis infiltration cT3 tumor. Due to the size of the expected defect and the risk of pharyngo-cervical fistulization as well as the functional deficit due to the wound surface, the decision is made to proceed primarily transcervically with defect reconstruction. The patient is repositioned for this. First perform flexible esophagogastroscopy to insert the PEG tube. Enter with the gastroscope under laryngoscopic control. If the diaphanoscopy is good, the stomach can be punctured without any problems. Subsequent insertion of the PEG tube using the usual thread pull-through method. Injection of xylocaine with added adrenaline, starting with the right side. Cervical cutting of skin and subcutaneous tissue along the anterior edge of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, the digastric muscle and the submandibular gland. The facial vein is exposed and ligated. Clearing of the anterior neck preparation with careful protection of the superior thyroid artery, the hypoglossal nerve and exact location of the superior laryngeal nerve, prolonged exposure and tracing and preservation of the nerve beyond the tumor resection. The internal jugular vein and the common carotid artery are now exposed. A metastasis-highly suspicious lesion can be dissected from the surrounding area, several suspicious lesions along the internal jugular vein. Exposure of the accessorius nerve. Excision of the accessorius triangle and level V, carefully preserving the transverse cervical artery of the cervical plexus and the vagus nerve. In toto removal of the neck preparation with in sano resection of all metastasis-suspected lesions. The thyroid cartilage is now released on the right side with dissection of the piriform sinus and visualization of the hyoid. Enter at the level of the right-sided vallecula. Widening of the pharyngotomy. Successive resection with 2/3 resection of the epiglottis, resection of the right aryepiglottic fold, resection of the arytenoid mucosa, leaving the intact joint intact. Subtotal resection of the right piriform sinus, the tip can be preserved. Resection up to the border of the posterior wall. After removal of the tumor, the specimen shows a somewhat scarce area basally, corresponding to the pre-epiglottic fatty tissue. This tissue is therefore completely resected. The specimen is thread-marked and sent for definitive histology together with the resected specimen. The invasive carcinoma is resected on the specimen R0, also in the basal section, only in the area of the pharyngeal side wall up to the cranial side is there a long stretch of Cis, so that an extensive resection is now carried out here. Renewed coverage with a mucosal margin sample, which was found to be completely free of tumor and dysplasia in the frozen section diagnostics, so that an R0 resection can be assumed. Measuring the defect and initially turning to plastic tracheotomy. Now turn to plastic tracheotomy. In the case of a post-thyroidectomy, use the old skin incision approx. 1 cm below the cricoid cartilage, cut through the skin and subcutaneous tissue. Removal of scars, exposure of the cricoid cartilage and the anterior surface of the trachea, insertion between the 2nd and 3rd tracheal ring, creation of a broad-based pedicled Björk flap and successive insertion of the tracheostoma. Neck dissection of the left side is then performed in parallel with radialis graft removal. For neck dissection: skin incision on the anterior edge of the sternocleidomastoid muscle. Separation of skin and subcutaneous tissue, dissection of the platysma, exposure of the sternocleidomastoid muscle, omohyoid muscle, digastric muscle, submandibular gland, removal of the anterior neck preparation with careful protection of the cervical artery, facial vein and superior thyroid artery. Free preparation of the cervical vascular sheath with exposure and protection of the vagus nerve, exposure and protection of the accessorius nerve, removal of the accessorius triangle and level V with careful protection of the cervical plexus branches. Overall, no suspicious nodules here, so that after final wound irrigation with Ringer's solution and dry wound conditions, a 10-gauge Redon drain was inserted with careful two-layer wound closure. Dictation : Removal of the forearm flap to cover the right hypopharyngeal defect. Mark the size of the defect, which is 6 x 8 cm. Then mark a skin monitor approx. 1 x 2 cm slightly proximal to the graft. Incision of the skin. Exposure of the brachioradialis muscle with exposure of the cephalic vein. Removal of the graft subfascially from the ulnar side. Exposure of the superficial venous system and removal of this. Exposure of the superficial ramus and radial nerve. Locating the radial artery. Clamping and ligation of this. Further removal of the radial and subfascial flap. Further subfascial dissection and elevation of the radial artery flap along the pedicle. Smaller outgoing vessels are bipolarly coagulated and treated, larger ones are clipped. In the elbow area, extension of the skin incision and exposure of the radial artery, radial vein, cephalic vein and inter cubital vein. The flap is removed. The veins are ligated and the radial artery is sutured with a 6-0 Vascufil suture. Irrigate the flap with heparin solution. \ No newline at end of file diff --git a/524/InvasionFront_CD3_block17_x5_y12_patient524_0.json b/524/InvasionFront_CD3_block17_x5_y12_patient524_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dcef2b9cbebf83506d691b9057c5daac08e63a2a --- /dev/null +++ b/524/InvasionFront_CD3_block17_x5_y12_patient524_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15416.8, + "Centroid Y µm": 35281.3, + "Num Detections": 15843, + "Num Negative": 14499, + "Num Positive": 1344, + "Positive %": 8.483, + "Num Positive per mm^2": 700.64 + } +} \ No newline at end of file diff --git a/524/InvasionFront_CD3_block17_x6_y12_patient524_1.json b/524/InvasionFront_CD3_block17_x6_y12_patient524_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b736892bbc923773b899db5a7c6016d9bd7a598 --- /dev/null +++ b/524/InvasionFront_CD3_block17_x6_y12_patient524_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17990.5, + "Centroid Y µm": 35356.3, + "Num Detections": 20036, + "Num Negative": 18107, + "Num Positive": 1929, + "Positive %": 9.628, + "Num Positive per mm^2": 865.34 + } +} \ No newline at end of file diff --git a/524/InvasionFront_CD8_block17_x5_y12_patient524_0.json b/524/InvasionFront_CD8_block17_x5_y12_patient524_0.json new file mode 100644 index 0000000000000000000000000000000000000000..18044a38d8bfaf6564a83de420ed2f25dc382834 --- /dev/null +++ b/524/InvasionFront_CD8_block17_x5_y12_patient524_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 29884.2, + "Num Detections": 18359, + "Num Negative": 17959, + "Num Positive": 400, + "Positive %": 2.179, + "Num Positive per mm^2": 180.67 + } +} \ No newline at end of file diff --git a/524/InvasionFront_CD8_block17_x6_y12_patient524_1.json b/524/InvasionFront_CD8_block17_x6_y12_patient524_1.json new file mode 100644 index 0000000000000000000000000000000000000000..84df634a2283dae5aa499566d77db3342c360a9d --- /dev/null +++ b/524/InvasionFront_CD8_block17_x6_y12_patient524_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 29859.2, + "Num Detections": 20809, + "Num Negative": 19685, + "Num Positive": 1124, + "Positive %": 5.402, + "Num Positive per mm^2": 479.37 + } +} \ No newline at end of file diff --git a/524/TumorCenter_CD3_block17_x5_y12_patient524_0.json b/524/TumorCenter_CD3_block17_x5_y12_patient524_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1b17a828d7846601e1bd30533e0f114abd6b7345 --- /dev/null +++ b/524/TumorCenter_CD3_block17_x5_y12_patient524_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15516.8, + "Centroid Y µm": 29784.2, + "Num Detections": 16996, + "Num Negative": 16099, + "Num Positive": 897, + "Positive %": 5.278, + "Num Positive per mm^2": 414.1 + } +} \ No newline at end of file diff --git a/524/TumorCenter_CD3_block17_x6_y12_patient524_1.json b/524/TumorCenter_CD3_block17_x6_y12_patient524_1.json new file mode 100644 index 0000000000000000000000000000000000000000..39fe7cbbe760cfe6e6d0a38c5a4e9b983146d166 --- /dev/null +++ b/524/TumorCenter_CD3_block17_x6_y12_patient524_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17865.5, + "Centroid Y µm": 29884.2, + "Num Detections": 19068, + "Num Negative": 17418, + "Num Positive": 1650, + "Positive %": 8.653, + "Num Positive per mm^2": 778.2 + } +} \ No newline at end of file diff --git a/524/TumorCenter_CD8_block17_x5_y12_patient524_0.json b/524/TumorCenter_CD8_block17_x5_y12_patient524_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5d9d7c4548b6fc7476485eb1c38b818cc79e8699 --- /dev/null +++ b/524/TumorCenter_CD8_block17_x5_y12_patient524_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 43402.0, + "Num Detections": 16556, + "Num Negative": 16188, + "Num Positive": 368, + "Positive %": 2.223, + "Num Positive per mm^2": 173.45 + } +} \ No newline at end of file diff --git a/524/TumorCenter_CD8_block17_x6_y12_patient524_1.json b/524/TumorCenter_CD8_block17_x6_y12_patient524_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8df7ce888add2c06a9834eb872aa7f2a8c41d44e --- /dev/null +++ b/524/TumorCenter_CD8_block17_x6_y12_patient524_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21088.8, + "Centroid Y µm": 43402.0, + "Num Detections": 19557, + "Num Negative": 18472, + "Num Positive": 1085, + "Positive %": 5.548, + "Num Positive per mm^2": 507.03 + } +} \ No newline at end of file diff --git a/524/history_text.txt b/524/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c4fd395faab4c0e46d146176b32c1b99edce118c --- /dev/null +++ b/524/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed squamous cell carcinoma in the area of the right anterior vocal fold, without reaching the anterior commissure. Based on the findings, there is an indication for the above-mentioned operation. The patient was informed preoperatively and had sufficient time to ask questions. \ No newline at end of file diff --git a/524/icd_codes.txt b/524/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/524/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/524/ops_codes.txt b/524/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c31d54d0b10aeab963fdbb65e88004b03bd39fdd --- /dev/null +++ b/524/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion Larynxgewebe[5-302.5 ] \ No newline at end of file diff --git a/524/patient_clinical_data.json b/524/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..39e19650c00234568b4c26677f8bf2beeabee0f5 --- /dev/null +++ b/524/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/524/patient_pathological_data.json b/524/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ce46046d2c5a84ae6f113bae3b47c726ff31edaa --- /dev/null +++ b/524/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "524", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 0.5 +} \ No newline at end of file diff --git a/524/surgery_description.txt b/524/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..35dd45fe83828a1d96f4ef17784a2dc6961c3a52 --- /dev/null +++ b/524/surgery_description.txt @@ -0,0 +1 @@ +mikrolaryng. Laserresektion diff --git a/524/surgery_report.txt b/524/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d5fbb0b012a3a862dba367a548e3164a201340fe --- /dev/null +++ b/524/surgery_report.txt @@ -0,0 +1 @@ +Transferring the patient to the operating theater. Carrying out the team time-out and preliminary consultation with the anesthesia colleagues. Induction of intubation anesthesia and intubation with a laser tube. Tube fixation in the left corner of the mouth. Head positioning in a slight reclining position by the surgeon. Entry into the larynx with the size D Kleinsasser tube and adjustment of the findings. There is an exophytic mass in the area of the anterior right vocal fold, which does not extend into the anterior commissure as described above, but ends 2 mm in front of it. Covering the patient with moist drapes and instillation of the CO2 laser. Successive laser resection of the findings with sufficient safety distance using 5 watts in continuous wave mode. The tumor can be held medially with the little tongue. The tumor extends approx. 2-3 mm below the free edge of the vocal fold. Dissection anteriorly down to the perichondrium of the thyroid cartilage. There is no evidence of infiltration of the anterior commissure, and certainly not of the left side of the vocal fold. Collection of 4 marginal samples (1: anterior commissure, 2: subglottic margin, 3: lateral margin of the vocal fold and 4: posterior margin) and submission of the samples for frozen section histopathological assessment. After feedback from the pathology colleagues, there was evidence of high-grade dysplasia in the area of the anterior and posterior commissure. Differential diagnostic artifacts due to the laser resection. After a detailed discussion of the findings, the colleagues could not decide whether it was an artifact or dysplasia. Therefore, in consultation with and , the decision was made to obtain 2 further marginal samples in the anterior and posterior commissure area and send them for final histopathological assessment. The operation was completed without complications and the surgical site was dry. Summary: Laser resection of a cT1a vocal fold carcinoma on the right side. Please note the final histopathological assessment and case presentation in our interdisciplinary tumor conference. A follow-up MLE should always be performed within 8 weeks. \ No newline at end of file diff --git a/525/InvasionFront_CD3_block15_x5_y7_patient525_0.json b/525/InvasionFront_CD3_block15_x5_y7_patient525_0.json new file mode 100644 index 0000000000000000000000000000000000000000..13aaa8ac7342c3caae7905ea25e0373ef3a2e8d4 --- /dev/null +++ b/525/InvasionFront_CD3_block15_x5_y7_patient525_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 27185.6, + "Num Detections": 20948, + "Num Negative": 18172, + "Num Positive": 2776, + "Positive %": 13.25, + "Num Positive per mm^2": 1167.6 + } +} \ No newline at end of file diff --git a/525/InvasionFront_CD3_block15_x6_y7_patient525_1.json b/525/InvasionFront_CD3_block15_x6_y7_patient525_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4e9ec5268cec11203aa035a36dbc863f3ac88d5d --- /dev/null +++ b/525/InvasionFront_CD3_block15_x6_y7_patient525_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21088.8, + "Centroid Y µm": 26985.7, + "Num Detections": 13642, + "Num Negative": 13017, + "Num Positive": 625, + "Positive %": 4.581, + "Num Positive per mm^2": 365.65 + } +} \ No newline at end of file diff --git a/525/InvasionFront_CD8_block15_x5_y7_patient525_0.json b/525/InvasionFront_CD8_block15_x5_y7_patient525_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fbc19c74c93313bd854ec77366411d134a2a3f7d --- /dev/null +++ b/525/InvasionFront_CD8_block15_x5_y7_patient525_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16336.3, + "Centroid Y µm": 17033.2, + "Num Detections": 20461, + "Num Negative": 19096, + "Num Positive": 1365, + "Positive %": 6.671, + "Num Positive per mm^2": 548.88 + } +} \ No newline at end of file diff --git a/525/InvasionFront_CD8_block15_x6_y7_patient525_1.json b/525/InvasionFront_CD8_block15_x6_y7_patient525_1.json new file mode 100644 index 0000000000000000000000000000000000000000..56ebe2f3fa5e870475606c4f9ae5cd793a73864a --- /dev/null +++ b/525/InvasionFront_CD8_block15_x6_y7_patient525_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18956.0, + "Centroid Y µm": 16988.4, + "Num Detections": 8533, + "Num Negative": 8294, + "Num Positive": 239, + "Positive %": 2.801, + "Num Positive per mm^2": 222.76 + } +} \ No newline at end of file diff --git a/525/TumorCenter_CD3_block15_x5_y7_patient525_0.json b/525/TumorCenter_CD3_block15_x5_y7_patient525_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2fdfaf8cfdca21c2efec57020c906c4af5cc39d9 --- /dev/null +++ b/525/TumorCenter_CD3_block15_x5_y7_patient525_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 21013.9, + "Num Detections": 16278, + "Num Negative": 12632, + "Num Positive": 3646, + "Positive %": 22.4, + "Num Positive per mm^2": 1762.7 + } +} \ No newline at end of file diff --git a/525/TumorCenter_CD3_block15_x6_y7_patient525_1.json b/525/TumorCenter_CD3_block15_x6_y7_patient525_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e6356a58cd837ffabadb181578c7a7c8c73ffda0 --- /dev/null +++ b/525/TumorCenter_CD3_block15_x6_y7_patient525_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 20963.9, + "Num Detections": 23197, + "Num Negative": 17350, + "Num Positive": 5847, + "Positive %": 25.21, + "Num Positive per mm^2": 2199.2 + } +} \ No newline at end of file diff --git a/525/TumorCenter_CD8_block15_x5_y7_patient525_0.json b/525/TumorCenter_CD8_block15_x5_y7_patient525_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a504410d0cfd26bcb830c0529400ca83ba7e3825 --- /dev/null +++ b/525/TumorCenter_CD8_block15_x5_y7_patient525_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 17440.8, + "Num Detections": 18563, + "Num Negative": 15632, + "Num Positive": 2931, + "Positive %": 15.79, + "Num Positive per mm^2": 1227.8 + } +} \ No newline at end of file diff --git a/525/TumorCenter_CD8_block15_x6_y7_patient525_1.json b/525/TumorCenter_CD8_block15_x6_y7_patient525_1.json new file mode 100644 index 0000000000000000000000000000000000000000..501aacd32419d5772c64b371b4127e01458ccd70 --- /dev/null +++ b/525/TumorCenter_CD8_block15_x6_y7_patient525_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21488.6, + "Centroid Y µm": 17415.8, + "Num Detections": 21301, + "Num Negative": 15799, + "Num Positive": 5502, + "Positive %": 25.83, + "Num Positive per mm^2": 2099.6 + } +} \ No newline at end of file diff --git a/525/history_text.txt b/525/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5aaa10e25c7290c41bf6c3b547479cb8294cd138 --- /dev/null +++ b/525/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: mass in the area of the edge of the tongue on the left, growing exulceratively. Localized in the area of the middle of the tongue, approx. 2 cm in size. \ No newline at end of file diff --git a/525/icd_codes.txt b/525/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d90fc37140299b299f51a1ba8ecbf62562b905f0 --- /dev/null +++ b/525/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 L] \ No newline at end of file diff --git a/525/ops_codes.txt b/525/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..316ee1559e3c86f0f2f6bc75c3d6f709eff7451c --- /dev/null +++ b/525/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/525/patient_clinical_data.json b/525/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..748c01085336fcad8e0d6896b72758aa948434cd --- /dev/null +++ b/525/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 67, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/525/patient_pathological_data.json b/525/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8535c538df35793211d20d63d4ac691e4c5305a8 --- /dev/null +++ b/525/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "525", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 6, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/525/surgery_description.txt b/525/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3245976762d96d412d2a3f83f3f3eff41023d88f --- /dev/null +++ b/525/surgery_description.txt @@ -0,0 +1 @@ +Resektion sowie Panendo diff --git a/525/surgery_report.txt b/525/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..858435d4d74bb17c5012e094e4f0696ae7e5ee8f --- /dev/null +++ b/525/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. First advance the 0° optic through the glottic plane into the trachea. Further advancement to the exit of the segmental bronchi on both sides. Inconspicuous mucosal conditions on all sides. Slow reflection back. No special features in the area of the cervical trachea. Intubation of the patient. Inspection of the glottis. No evidence of malignant mucosal changes in the subglottis, glottis and supraglottis. Inspection of the hypopharynx on both sides with the small siphon tube and the postcricoid region. Inconspicuous mucosal conditions. No abnormalities in the oropharynx, oral cavity or after pulling up the soft palate in the nasopharynx. Advance the flexible endoscope into the stomach. Careful reflection back. No special features in the area of the esophagus. Insertion of the mouth blocker. The tumor can now be seen in the area of the right edge of the tongue, located approximately in the middle of the tongue. The tumor grows exulcerating. Clinically safe cutting around the tumor in all planes. The lingual artery is exposed and ligated. Removal of the tumor. Marking of the specimen. During frozen section histology, the diagnosis of squamous cell carcinoma is made and the resection in sano is also confirmed histologically. After careful hemostasis, inverting adaptation of the wound edges and closure of the resection area. Completion of the procedure. Final consultation with the anesthetist. The patient is transferred to the recovery ward. \ No newline at end of file diff --git a/526/InvasionFront_CD3_block13_x1_y5_patient526_0.json b/526/InvasionFront_CD3_block13_x1_y5_patient526_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7f6d0493c40d0772220455d21e19460e4e0cec8e --- /dev/null +++ b/526/InvasionFront_CD3_block13_x1_y5_patient526_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3748.0, + "Centroid Y µm": 11793.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/526/InvasionFront_CD3_block13_x2_y5_patient526_1.json b/526/InvasionFront_CD3_block13_x2_y5_patient526_1.json new file mode 100644 index 0000000000000000000000000000000000000000..30504934c1109d5dc2bed26456a1969ab2d44d37 --- /dev/null +++ b/526/InvasionFront_CD3_block13_x2_y5_patient526_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 11768.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/526/InvasionFront_CD8_block13_x1_y5_patient526_0.json b/526/InvasionFront_CD8_block13_x1_y5_patient526_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0d26751416a87c91cb61df8b80d8ade4209ddf85 --- /dev/null +++ b/526/InvasionFront_CD8_block13_x1_y5_patient526_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4797.5, + "Centroid Y µm": 12993.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/526/InvasionFront_CD8_block13_x2_y5_patient526_1.json b/526/InvasionFront_CD8_block13_x2_y5_patient526_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3cbf1f33a5bfb236dd8a361ccd37b630b3d7e25e --- /dev/null +++ b/526/InvasionFront_CD8_block13_x2_y5_patient526_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7271.2, + "Centroid Y µm": 13118.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/526/TumorCenter_CD3_block13_x1_y5_patient526_0.json b/526/TumorCenter_CD3_block13_x1_y5_patient526_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7c20b3e3a6f075fb7d34156e7c2daff11edbecfe --- /dev/null +++ b/526/TumorCenter_CD3_block13_x1_y5_patient526_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4772.5, + "Centroid Y µm": 18215.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/526/TumorCenter_CD3_block13_x2_y5_patient526_1.json b/526/TumorCenter_CD3_block13_x2_y5_patient526_1.json new file mode 100644 index 0000000000000000000000000000000000000000..95c4ae422cb571178206e9e082d4a04acca1958c --- /dev/null +++ b/526/TumorCenter_CD3_block13_x2_y5_patient526_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7396.1, + "Centroid Y µm": 18415.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/526/TumorCenter_CD8_block13_x1_y5_patient526_0.json b/526/TumorCenter_CD8_block13_x1_y5_patient526_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4f8f7cf4c7e3a5f6e7e16817a32bda5cef0596d1 --- /dev/null +++ b/526/TumorCenter_CD8_block13_x1_y5_patient526_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4272.7, + "Centroid Y µm": 13492.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/526/TumorCenter_CD8_block13_x2_y5_patient526_1.json b/526/TumorCenter_CD8_block13_x2_y5_patient526_1.json new file mode 100644 index 0000000000000000000000000000000000000000..298de13acdde4d5f1befa2842f137ea10c2edee7 --- /dev/null +++ b/526/TumorCenter_CD8_block13_x2_y5_patient526_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 13168.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/526/history_text.txt b/526/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b369d054a7a5f81a4eacfceac89b302d3e224aa6 --- /dev/null +++ b/526/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT4a cN2c hypopharyngeal carcinoma on the right was histologically confirmed during a panendoscopy <2014>. In our interdisciplinary tumor conference, the primary surgical procedure was recommended. In the case of sonographic evidence of infiltration of the right common carotid artery, preoperative consultation was also carried out with colleagues from vascular surgery for a joint approach if necessary. \ No newline at end of file diff --git a/526/icd_codes.txt b/526/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8942df050249e3880166bd6eaf35efe4c40f2c9 --- /dev/null +++ b/526/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] \ No newline at end of file diff --git a/526/ops_codes.txt b/526/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..01e5ed323a12bf6e46c261c4a8fbf9c45865c211 --- /dev/null +++ b/526/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale erweiterte Neck dissection in 5 Regionen[5-403.31 R] Modifizierte radikale Neck dissection in 6 Regionen[5-403.22 L] Permanente Tracheotomie[5-312.0 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] \ No newline at end of file diff --git a/526/patient_clinical_data.json b/526/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7b2ec0e77a191e819a92af712a9dd89c4bc1b07f --- /dev/null +++ b/526/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/526/patient_pathological_data.json b/526/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ec68e0280b94ef1e538360e58e905b306c410d10 --- /dev/null +++ b/526/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "526", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 12.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/526/surgery_description.txt b/526/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..dc71876e21c9d3dbaf3943d57cc806693bcb19d6 --- /dev/null +++ b/526/surgery_description.txt @@ -0,0 +1 @@ +Laryngektomie, Neck dissection sowie Tracheotomie diff --git a/526/surgery_report.txt b/526/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..91c527eb335444ee1e9e7fbcebdc45d02b0e822f --- /dev/null +++ b/526/surgery_report.txt @@ -0,0 +1 @@ +After intubation and induction of anesthesia by the anesthesiology colleagues, a pharyngo-laryngoscopy is performed for re-evaluation. Here, the exophytic tumor process can already be seen in the area of the right oropharynx, starting at the border to the hypopharynx, in the area of the right pharyngeal side wall, the extensive exophytic tumor process moves over the right pharyngeal side wall into the piriform sinus, fills it completely, fixes the larynx here over the medial wall and also clearly moves postcricoidally here, the esophageal entrance is free, as is the posterior wall of the hypopharynx. In the region of the endolarynx, it is edematous and swollen on the right and regular on the left. Due to the absolute fixation, confirmation of the indication for laryngectomy. The patient is now repositioned and xylocaine with adrenaline is injected. Lifting of a broad-based apron flap. Start with the right side first. Extensive metastasis consisting of 2 large conglomerates, one in level II with palpatory clear infiltration of the sternocleidomastoid muscle and one extending caudally to the supraclavicular region, mainly in level IV and V to Vb. The sternocleidomastoid muscle is visualized for orientation. Subsequently, the muscle is placed on the mastoid and caudally. Exposure of the omohyoid muscle, which is also infiltrated in level IV, cranial exposure of the submandibular gland, exposure of the facial vein, which is later ligated, exposure of the digastric muscle, which can just be bluntly detached from the metastasis block. No infiltration here. Cranial exposure of the internal jugular vein, this is already very thin here, the accessorius nerve is no longer exposed here. Exposure and preservation of the carotid artery with hypoglossal nerve, exposure and preservation of the vagus nerve, cranial removal of the internal jugular vein, caudal dissection with subtotal resection of the cervical plexus. Skeletonization of the carotid bulb and the common carotid artery. After dissection, this can be pushed away from the metastatic block completely including the adventitia, partly bluntly, no signs of infiltration here. Caudally just above the mouth of the subclavian vein, separation of the internal jugular vein with overall extensive infiltration and obliteration, caudally good separation from the brachial plexus, no signs of infiltration here either, so that overall the complete metastatic block can be extirpated in toto and in sano. The vagus nerve was also preserved along the entire route. Residues of level Ia and level VI are extirpated, followed by visualization and release of the hyoid on the right side. Release of the thyroid cartilage in case of tumor growth, but certainly no tumor breakthrough. Covering of the soft tissues of the neck everywhere. However, the paralaryngeal muscles on the right side were left intact. Mobilization of the larynx only caudally. Detachment of the thyroid gland and preservation of the superior thyroid artery. Exposure and exposure of cricoid cartilage and trachea. On the left side now classic dissection and skeletonization of the larynx. Detachment of the paralaryngeal and infrahyoid muscles. Exposure of the thyroid horn, sharp release of the piriform sinus. Now enter cranial to the hyoid due to the extent of the tumor on the left. Paramedian successive extension of the pharyngotomy via the left-sided vallecula, sparing and mucosa-sparing resection in the area of the aryepiglottic fold on the left up to the postcricoid while preserving and releasing the piriform sinus. On the right side, the tumor is incised in situ with a safety margin of approx. 1.5 cm, taking the pharyngeal musculature with it and thus also safely in sano in depth. Resection up to the postcricoid, here about half of the tumor is affected. Healthy conditions on all sides towards the esophageal entrance. Finally, removal of the specimen below the cricoid cartilage. Inspection of the tumor, practically no extension subglottically and wide in sano resection here, the tumor is resected in sano on all sides on the specimen, so that the marginal sample is taken on the specimen. Only in the area of the postcricoid region is there a somewhat narrower distance after removal of the tumor block, which is why complete imaging of the mucosa and margin samples is performed in situ. In the frozen section diagnostics, all marginal samples are free of tumor and dysplasia, so that an R0 situation can be assumed. The neck dissection of the left side is now performed. Here, metastasis at the transition from level II to Va behind the internal jugular vein. Macroscopic visualization of the omohyoid muscle and digastric muscle. Release of the submandibular gland, visualization of the omohyoid muscle, digastric muscle. Release of the submandibular gland, exposure of the sternocleidomastoid muscle, free preparation of the internal jugular vein while preserving the facial vein. Exposure and preservation of the accessorius nerve, hypoglossal nerve and cervical artery. Exposure and preservation of the superior thyroid artery. The metastasis described above can be removed in sano without any signs of surrounding infiltration. Further borderline enlarged lymph nodes on the internal jugular vein are resected en bloc with the neck dissection which extends to level Va. Final palpation also on both sides in the nuchal and supraclavicular direction, no further abnormalities, so that after wound irrigation, the Provox voice prosthesis is initially placed here with a regular esophageal entrance, good mucosal conditions and a regular trachea. The trachea is adjusted by creating a dorsal elevation. Easy insertion of a size 8 Provox prosthesis at the most cranial point possible. Particularly in the area of the caudal pharyngeal tube and the esophageal entrance, the mucosa is wide, so that after a demonstration of the findings at and a primary suture of the mucosa is performed in several layers, especially including the base of the tongue in the case of a larger defect on the right side due to the extent of the tumor. Finally, wide conditions and an intact pharyngeal tube on all sides. Due to the skeletonized common carotid artery and the larger pharyngeal defect, the right thyroid lobe is now rotated to reline the pharyngeal suture. Release of the right thyroid lobe with removal of the inferior pole. The thyroid gland is now stitched onto the stalk of the superior thyroid artery and the accompanying veins, particularly on the cranial part of the pharyngeal suture. Good positioning. Subsequent final wound irrigation and, if the wound is dry, insertion of a 10-gauge Redon drain. Careful two-layer wound closure and insertion of the tracheostoma. Subsequent problem-free reintubation to a size 10 low cuff cannula. Conclusion: Intraoperative R0 resected cT4a cN2c cM0 G3 hypopharyngeal carcinoma on the right. Postoperatively, forced adjuvant therapy is certainly required due to the advanced metastasis. An X-ray pelvis was performed on the 10th postoperative day. If there are signs of a pharnygocutaneous fistula, please report this to the surgeon at an early stage. \ No newline at end of file diff --git a/527/InvasionFront_CD3_block11_x3_y8_patient527_0.json b/527/InvasionFront_CD3_block11_x3_y8_patient527_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d1560c42df1b0af53d6943b3ac38e86bcd546a39 --- /dev/null +++ b/527/InvasionFront_CD3_block11_x3_y8_patient527_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10694.3, + "Centroid Y µm": 19239.8, + "Num Detections": 18496, + "Num Negative": 18236, + "Num Positive": 260, + "Positive %": 1.406, + "Num Positive per mm^2": 122.12 + } +} \ No newline at end of file diff --git a/527/InvasionFront_CD3_block11_x4_y8_patient527_1.json b/527/InvasionFront_CD3_block11_x4_y8_patient527_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a463862620e52c1c57710ab30ca756bab5ea543f --- /dev/null +++ b/527/InvasionFront_CD3_block11_x4_y8_patient527_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13317.9, + "Centroid Y µm": 19139.9, + "Num Detections": 19258, + "Num Negative": 18997, + "Num Positive": 261, + "Positive %": 1.355, + "Num Positive per mm^2": 115.77 + } +} \ No newline at end of file diff --git a/527/InvasionFront_CD8_block11_x3_y8_patient527_0.json b/527/InvasionFront_CD8_block11_x3_y8_patient527_0.json new file mode 100644 index 0000000000000000000000000000000000000000..357767b82143d055023a3bd3eba8b9df59d6d99f --- /dev/null +++ b/527/InvasionFront_CD8_block11_x3_y8_patient527_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13597.5, + "Centroid Y µm": 30388.8, + "Num Detections": 11031, + "Num Negative": 11011, + "Num Positive": 20, + "Positive %": 0.1813, + "Num Positive per mm^2": 14.88 + } +} \ No newline at end of file diff --git a/527/InvasionFront_CD8_block11_x4_y8_patient527_1.json b/527/InvasionFront_CD8_block11_x4_y8_patient527_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8532b02511c0d71a2ab4c48be52b937773a76d97 --- /dev/null +++ b/527/InvasionFront_CD8_block11_x4_y8_patient527_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16181.4, + "Centroid Y µm": 30357.0, + "Num Detections": 4840, + "Num Negative": 4826, + "Num Positive": 14, + "Positive %": 0.2893, + "Num Positive per mm^2": 23.03 + } +} \ No newline at end of file diff --git a/527/TumorCenter_CD3_block11_x3_y8_patient527_0.json b/527/TumorCenter_CD3_block11_x3_y8_patient527_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cd0af6d8fb7f1a01ace4caab26ecdc4f90119f51 --- /dev/null +++ b/527/TumorCenter_CD3_block11_x3_y8_patient527_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 19664.6, + "Num Detections": 18558, + "Num Negative": 18335, + "Num Positive": 223, + "Positive %": 1.202, + "Num Positive per mm^2": 94.96 + } +} \ No newline at end of file diff --git a/527/TumorCenter_CD3_block11_x4_y8_patient527_1.json b/527/TumorCenter_CD3_block11_x4_y8_patient527_1.json new file mode 100644 index 0000000000000000000000000000000000000000..31a6fb3584a113ebfee4cf7a6b19737d8d7e5c63 --- /dev/null +++ b/527/TumorCenter_CD3_block11_x4_y8_patient527_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 19789.5, + "Num Detections": 14300, + "Num Negative": 14179, + "Num Positive": 121, + "Positive %": 0.8462, + "Num Positive per mm^2": 65.61 + } +} \ No newline at end of file diff --git a/527/TumorCenter_CD8_block11_x3_y8_patient527_0.json b/527/TumorCenter_CD8_block11_x3_y8_patient527_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fb7ffa18b28af21896ddabf5184b1f5965edc56d --- /dev/null +++ b/527/TumorCenter_CD8_block11_x3_y8_patient527_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 19489.7, + "Num Detections": 20021, + "Num Negative": 19928, + "Num Positive": 93, + "Positive %": 0.4645, + "Num Positive per mm^2": 37.37 + } +} \ No newline at end of file diff --git a/527/TumorCenter_CD8_block11_x4_y8_patient527_1.json b/527/TumorCenter_CD8_block11_x4_y8_patient527_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7700e4e6a54af7017738606ce4b6ea1e260a5f3a --- /dev/null +++ b/527/TumorCenter_CD8_block11_x4_y8_patient527_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13992.6, + "Centroid Y µm": 19489.7, + "Num Detections": 18762, + "Num Negative": 18592, + "Num Positive": 170, + "Positive %": 0.9061, + "Num Positive per mm^2": 73.99 + } +} \ No newline at end of file diff --git a/527/history_text.txt b/527/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6d04093edf1edfaf11c8df2bac59ac340e708401 --- /dev/null +++ b/527/history_text.txt @@ -0,0 +1 @@ +Following extirpation of a glomus caroticum tumor on the left <2009>, a mass in the area of the aryepiglottic fold on the right was discovered during tumor follow-up for dysphagia complaints <2009>. Therefore, there was now an indication for panendoscopy with removal of the mass if necessary. \ No newline at end of file diff --git a/527/icd_codes.txt b/527/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0a20e134b6f066c677d7064aeb929f168e684dd --- /dev/null +++ b/527/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren Verhaltens aryepiglottische Falte hypopharyngeale Seite[D37.0 ] \ No newline at end of file diff --git a/527/ops_codes.txt b/527/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ba21cb24ae602cb361991e6000d091bb3e80d691 --- /dev/null +++ b/527/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument[1-620.1 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Partielle Laryngektomie endoskopische Laserresektion[5-302.5 ] \ No newline at end of file diff --git a/527/patient_clinical_data.json b/527/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ff7fca8c3516ae733dd19d75193830f94dad0e42 --- /dev/null +++ b/527/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 76, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/527/patient_pathological_data.json b/527/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8e2cf6f24449c17faa2483408939e1fc4e6398d6 --- /dev/null +++ b/527/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "527", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 12, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/527/surgery_description.txt b/527/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..814edb22ccdb5e65b70a886ab276318165e010f7 --- /dev/null +++ b/527/surgery_description.txt @@ -0,0 +1 @@ +Laserresektion i.B. Sinus piriformis rechts, Panendo diff --git a/527/surgery_report.txt b/527/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9c69561b44eff12fea2026173e8a21003ab3e288 --- /dev/null +++ b/527/surgery_report.txt @@ -0,0 +1 @@ +After problem-free induction of anesthesia by the anesthesia colleagues, the tracheoscopy is first performed with the rigid endoscope. The mucosal conditions in the glottis and subglottis area are normal, the trachea is freely visible up to the carina, with no evidence of a stenosing or exophytic mass. Then removal of the rigid endoscope and intubation by the surgeon. After positioning the patient's head low and inserting a mouth guard, a Kleinsasser C-tube is then carefully inserted. The mucous membrane in the area of the oral cavity, the tonsilloliths on both sides, palatal arches, uvula and the tongue and base of the tongue are found to be free of irritation. Now further advancement into the deep pharyngeal region. Here, the mucosa in the area of the vallecula and the posterior pharyngeal wall is also free of irritation. Now advance into the area of the left hypopharynx, where the mucosa is also without irritation. The left piriform sinus is freely visible up to the esophageal orifice. Now, the right hypopharynx can be seen. Here, a verrucous, partially exophytically growing spherical mass in the sense of a cT1 tumor can be seen at the piriform sinus entrance with transition to the aryepiglottic fold on the right. The .................. hypopharynx on the right up to the esophageal orifice appears clear. Next, the laryngeal region, epiglottis, the folds of the pouch, arytenoid humps and the vocal folds on both sides appear with smooth, non-irritated mucosa with no evidence of exophytic tumor growth. Finally, removal of the Kleinsasser tube and flexible esophagogastroscopy. Easy visualization in the stomach area. Overall, atrophic mucosal conditions are seen here without any indication of an ulcerous or exophytic growing mass. Careful retraction of the flexible endoscope in the area of the gastroesophageal junction, also irritation-free mucosal conditions with no indication of a Barret's esophagus. The mucosa in the rest of the esophagus is also unremarkable. Then removal of the flexible endoscope and insertion of a Kleinsasser tube again after insertion of a dental protector. Now visualization of the verrucous mass again in the area of the right hypopharyngeal inlet and demonstration of the findings on . With an overall more clinically malignant aspect, the decision was then made to perform laser resection of the cT1 tumor. The tumor is carefully excised in toto clinically in healthy tissue using the laser. Minor bleeding is stopped using monopolar coagulation. The excised specimen with the verrucous exophytic tumor is then thread-marked for histological examination. Finally, a laser resection is performed at the cranial resection margin, which is also sent for histological evaluation. At the end of the operation, the wound is dry. The patient receives 250 mg SDH intraoperatively. The Kleinsasser tube and the mouth guard are then easily removed and the patient's head is repositioned. \ No newline at end of file diff --git a/528/InvasionFront_CD3_block21_x3_y6_patient528_0.json b/528/InvasionFront_CD3_block21_x3_y6_patient528_0.json new file mode 100644 index 0000000000000000000000000000000000000000..89aa2077ef1a6e7c942524e62c265ba942da5dca --- /dev/null +++ b/528/InvasionFront_CD3_block21_x3_y6_patient528_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 25436.5, + "Num Detections": 15883, + "Num Negative": 15809, + "Num Positive": 74, + "Positive %": 0.4659, + "Num Positive per mm^2": 39.74 + } +} \ No newline at end of file diff --git a/528/InvasionFront_CD3_block21_x4_y6_patient528_1.json b/528/InvasionFront_CD3_block21_x4_y6_patient528_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b17aae0f216edaecd835b591cee539f7eb83a8e --- /dev/null +++ b/528/InvasionFront_CD3_block21_x4_y6_patient528_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 25686.4, + "Num Detections": 16137, + "Num Negative": 15261, + "Num Positive": 876, + "Positive %": 5.429, + "Num Positive per mm^2": 465.66 + } +} \ No newline at end of file diff --git a/528/InvasionFront_CD8_block21_x3_y6_patient528_0.json b/528/InvasionFront_CD8_block21_x3_y6_patient528_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9114a35b639f4f6eb72e6324014dd76d1784781c --- /dev/null +++ b/528/InvasionFront_CD8_block21_x3_y6_patient528_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 14592.3, + "Num Detections": 14567, + "Num Negative": 14531, + "Num Positive": 36, + "Positive %": 0.2471, + "Num Positive per mm^2": 20.27 + } +} \ No newline at end of file diff --git a/528/InvasionFront_CD8_block21_x4_y6_patient528_1.json b/528/InvasionFront_CD8_block21_x4_y6_patient528_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b2d6430fd48dfbc2874b0d2e1e70ec315971f515 --- /dev/null +++ b/528/InvasionFront_CD8_block21_x4_y6_patient528_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 14717.2, + "Num Detections": 15275, + "Num Negative": 14210, + "Num Positive": 1065, + "Positive %": 6.972, + "Num Positive per mm^2": 591.95 + } +} \ No newline at end of file diff --git a/528/TumorCenter_CD3_block21_x3_y6_patient528_0.json b/528/TumorCenter_CD3_block21_x3_y6_patient528_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e176a966c1ac841bce09f343c8f9e8f3d54719d3 --- /dev/null +++ b/528/TumorCenter_CD3_block21_x3_y6_patient528_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 17965.5, + "Num Detections": 4156, + "Num Negative": 3903, + "Num Positive": 253, + "Positive %": 6.088, + "Num Positive per mm^2": 530.16 + } +} \ No newline at end of file diff --git a/528/TumorCenter_CD3_block21_x4_y6_patient528_1.json b/528/TumorCenter_CD3_block21_x4_y6_patient528_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eaf1a96cc16c10759b8ff4ddf31a376c5a656613 --- /dev/null +++ b/528/TumorCenter_CD3_block21_x4_y6_patient528_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 17640.7, + "Num Detections": 11586, + "Num Negative": 11197, + "Num Positive": 389, + "Positive %": 3.358, + "Num Positive per mm^2": 262.13 + } +} \ No newline at end of file diff --git a/528/TumorCenter_CD8_block21_x3_y6_patient528_0.json b/528/TumorCenter_CD8_block21_x3_y6_patient528_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eeb72da494ad2f5e74cb5fee1878d8db7df88121 --- /dev/null +++ b/528/TumorCenter_CD8_block21_x3_y6_patient528_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 29784.2, + "Num Detections": 15034, + "Num Negative": 14572, + "Num Positive": 462, + "Positive %": 3.073, + "Num Positive per mm^2": 247.04 + } +} \ No newline at end of file diff --git a/528/TumorCenter_CD8_block21_x4_y6_patient528_1.json b/528/TumorCenter_CD8_block21_x4_y6_patient528_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9ee8e9f34679a6d5b31d0f91ffac219759bed03e --- /dev/null +++ b/528/TumorCenter_CD8_block21_x4_y6_patient528_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 29909.2, + "Num Detections": 11280, + "Num Negative": 10977, + "Num Positive": 303, + "Positive %": 2.686, + "Num Positive per mm^2": 209.44 + } +} \ No newline at end of file diff --git a/528/history_text.txt b/528/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a3ce357b0e10c41a4197dfc984fe27b4c97da317 --- /dev/null +++ b/528/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT4 laryngeal carcinoma. Endolarynx completely filled, carcinoma breaks through the thyroid cartilage or the laryngeal skeleton and also through the prelaryngeal skin. Therefore, the above-mentioned surgery is indicated. \ No newline at end of file diff --git a/528/icd_codes.txt b/528/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/528/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/528/ops_codes.txt b/528/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4623fdf6d75ace1edcb9b1a595fdd353c9021133 --- /dev/null +++ b/528/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie ohne Rekonstruktion[5-303.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] Myotomie M. constrictor pharyngis ohne Pharyngotomie[5-299.00 ] Plastische Rekonstruktion mit myokutanem Lappen gefäßgestielt Brustwand und Rücken[5-857.75 R] \ No newline at end of file diff --git a/528/patient_clinical_data.json b/528/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5da173efec217e0f7af7823a9fe78a6f247f3d21 --- /dev/null +++ b/528/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 47, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/528/patient_pathological_data.json b/528/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..81f8ed15ef6ec248d3f48aa71bd3275c3e70027a --- /dev/null +++ b/528/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "528", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 35.0 +} \ No newline at end of file diff --git a/528/surgery_description.txt b/528/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..408640ed6dd9edde0d578ce03aeaafef1eba8bfe --- /dev/null +++ b/528/surgery_description.txt @@ -0,0 +1 @@ +Laryngektomie, Neck diss bds. diff --git a/528/surgery_report.txt b/528/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..21f960e47f6696f4b18f5e288eabd96d7918172e --- /dev/null +++ b/528/surgery_report.txt @@ -0,0 +1 @@ +This is followed by bronchoscopic intubation. Then laryngoscopy and pharyngoscopy again: this confirms the preoperative findings, no infiltration of the pharynx. Now inject a total of 15 ml Ultracaine 1 % with adrenaline. Skin disinfection and sterile draping. Then outline the infiltrated skin. A distance of 1 cm with resection of the skin island, which remains on the laryngeal skeleton. Outside the resection, a circular margin sample is taken, which contains skin and soft tissue. No tumor infiltrates here. Thus free in the area of the neck skin. The rest of the neck skin is then lifted in the form of a subplatysmal flap. Skin remains somewhat more fixed in the cranial area for blood circulation. Beginning with neck dissection on the right: exposing the sternocleidomastoid muscle, exposing the omohyoid and digastric muscles. Cranially there are tumor-infiltrated lymph nodes in level II. The facial vein is dissected and ligated. The hypoglossal nerve is exposed and preserved. Cervical vascular sheath is exposed, internal jugular vein, internal and external carotid artery are preserved. Vagus nerve is visualized and preserved. N. accessorius is exposed and preserved. The lymph nodes are then removed from levels II to V, whereby the branches of the cervical plexus are preserved. The superior thyroid artery is exposed and preserved. Subsequent neck dissection on the left side: Level II to IV are removed in the same way as on the right side. The thoracic duct is exposed caudally but not opened. Subsequent laryngectomy: mobilization of the laryngeal skeleton on both sides in the same way. Mobilization of the thyroid gland caudo-laterally. Exposure of the hyoid bone and detachment from the suprahyoid muscles. Exposure of the superior cornu and detachment of the pharyngeal constrictor and dissection of the piriform sinus. Subsequent entry into the larynx at the level of the epiglottis. Successive development of the larynx from cranial to caudal. The trachea was previously opened caudally and partially epithelized. Re-intubation and insertion of a ventilation tube. The larynx is then developed and set down. The larynx is sent as a complete preparation for frozen section. The tumor margins are then all free in the frozen section. Pharyngeal tube easily passable at the entrance area, therefore no myotomy necessary. Insertion of an 8 mm Provox prosthesis without complications. The pharyngeal tube is then sutured. The mucosa is sutured inverted in a first layer. In a second layer, the first suture is inverted by another inverting suture. The pharyngeal tube is then sutured. This is followed by irrigation of the entire wound area with H202 and Ringer's solution. Subsequent inspection of the neck skin and measurement of the defect. Measure the length of the pedicle. Mark the pectoralis flap in the appropriate size and at the appropriate distance on the right chest wall. Create a subfascial skin bridge on the pectoralis major flap. Then develop the pectoralis major flap successively by placing ........... sutures. The vascular pedicle was previously identified under the pectoralis major. Successive development of the flap along its pedicle up to the clavicle. Insertion of the flap under the skin bridge into the neck skin defect. Then suture the pectoralis flap into the skin defect and simultaneously epithelialize the tracheostoma. Closure of the neck skin with insertion of a Redon drain after careful hemostasis and repeated irrigation in layers on both sides. Subsequent mobilization of the thoracic skin and, after careful haemostasis and irrigation, low tension closure of this after insertion of 2 Redon drains. Insertion of a 10 mm tracheostomy tube without any problems. The procedure was completed without complications. Overall cT4a laryngeal carcinoma with invasion of the prelaryngeal skin and soft tissue. R0 situation, neck dissection on both sides of the suspicious cranial lymph nodes in level II on both sides. Postoperative according to the histological findings, at least RT, possibly RCT. Feeding via PEG tube for 10 days, then gruel and, if necessary, diet build-up. Continue antibiotics with Unacid for a further 1-2 days. \ No newline at end of file diff --git a/529/InvasionFront_CD3_block17_x3_y8_patient529_0.json b/529/InvasionFront_CD3_block17_x3_y8_patient529_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e977c48090fb796519e169041f0c97eb03d4582b --- /dev/null +++ b/529/InvasionFront_CD3_block17_x3_y8_patient529_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 25261.6, + "Num Detections": 19754, + "Num Negative": 19019, + "Num Positive": 735, + "Positive %": 3.721, + "Num Positive per mm^2": 312.18 + } +} \ No newline at end of file diff --git a/529/InvasionFront_CD3_block17_x4_y8_patient529_1.json b/529/InvasionFront_CD3_block17_x4_y8_patient529_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0cf6df3c2ea13df9af36a6c20d46745113174fd --- /dev/null +++ b/529/InvasionFront_CD3_block17_x4_y8_patient529_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 25336.6, + "Num Detections": 19939, + "Num Negative": 19604, + "Num Positive": 335, + "Positive %": 1.68, + "Num Positive per mm^2": 136.64 + } +} \ No newline at end of file diff --git a/529/InvasionFront_CD8_block17_x3_y8_patient529_0.json b/529/InvasionFront_CD8_block17_x3_y8_patient529_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b92cd53619ac773d776639b63d5ece11e6deac4f --- /dev/null +++ b/529/InvasionFront_CD8_block17_x3_y8_patient529_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 20264.3, + "Num Detections": 19925, + "Num Negative": 19889, + "Num Positive": 36, + "Positive %": 0.1807, + "Num Positive per mm^2": 15.82 + } +} \ No newline at end of file diff --git a/529/InvasionFront_CD8_block17_x4_y8_patient529_1.json b/529/InvasionFront_CD8_block17_x4_y8_patient529_1.json new file mode 100644 index 0000000000000000000000000000000000000000..170d6f34a82ef799fd964f2d23a36c8bc3353986 --- /dev/null +++ b/529/InvasionFront_CD8_block17_x4_y8_patient529_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 20264.3, + "Num Detections": 20155, + "Num Negative": 20000, + "Num Positive": 155, + "Positive %": 0.769, + "Num Positive per mm^2": 63.73 + } +} \ No newline at end of file diff --git a/529/TumorCenter_CD3_block17_x3_y8_patient529_0.json b/529/TumorCenter_CD3_block17_x3_y8_patient529_0.json new file mode 100644 index 0000000000000000000000000000000000000000..99ab99a4c36edca9ae9b7d70d1af6af9fedaa580 --- /dev/null +++ b/529/TumorCenter_CD3_block17_x3_y8_patient529_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 19989.4, + "Num Detections": 16139, + "Num Negative": 14872, + "Num Positive": 1267, + "Positive %": 7.851, + "Num Positive per mm^2": 640.96 + } +} \ No newline at end of file diff --git a/529/TumorCenter_CD3_block17_x4_y8_patient529_1.json b/529/TumorCenter_CD3_block17_x4_y8_patient529_1.json new file mode 100644 index 0000000000000000000000000000000000000000..42569d6d4e49ea3d8fe082ddbbf0d21441986f3b --- /dev/null +++ b/529/TumorCenter_CD3_block17_x4_y8_patient529_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 19964.4, + "Num Detections": 18991, + "Num Negative": 18706, + "Num Positive": 285, + "Positive %": 1.501, + "Num Positive per mm^2": 116.43 + } +} \ No newline at end of file diff --git a/529/TumorCenter_CD8_block17_x3_y8_patient529_0.json b/529/TumorCenter_CD8_block17_x3_y8_patient529_0.json new file mode 100644 index 0000000000000000000000000000000000000000..04760f7f64dd748fa9ab8d4e2404457ba3680a7a --- /dev/null +++ b/529/TumorCenter_CD8_block17_x3_y8_patient529_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 33832.1, + "Num Detections": 19583, + "Num Negative": 19385, + "Num Positive": 198, + "Positive %": 1.011, + "Num Positive per mm^2": 85.31 + } +} \ No newline at end of file diff --git a/529/TumorCenter_CD8_block17_x4_y8_patient529_1.json b/529/TumorCenter_CD8_block17_x4_y8_patient529_1.json new file mode 100644 index 0000000000000000000000000000000000000000..86dad21c6bb3e2fcc655ed9d7babd47397233356 --- /dev/null +++ b/529/TumorCenter_CD8_block17_x4_y8_patient529_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 33682.2, + "Num Detections": 19693, + "Num Negative": 19600, + "Num Positive": 93, + "Positive %": 0.4722, + "Num Positive per mm^2": 38.93 + } +} \ No newline at end of file diff --git a/529/history_text.txt b/529/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..75f9c89ac02e207fb4fa6e55d87fb624d39c53dd --- /dev/null +++ b/529/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed G2 squamous cell carcinoma cT2 cN0, originating from the right glottis with infiltration of the left vocal fold via the anterior commissure and slight subglottic spread, indication for transcervical procedure due to poor adjustability. Perform the operation in accordance with the treatment recommendation of the head and neck tumor board. \ No newline at end of file diff --git a/529/icd_codes.txt b/529/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/529/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/529/ops_codes.txt b/529/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..441180f82a254a8391a000bf78fd738a44dec8ee --- /dev/null +++ b/529/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte Hypopharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/529/patient_clinical_data.json b/529/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..af979414c7f9dc133dffc8e51f29005a05abb35a --- /dev/null +++ b/529/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/529/patient_pathological_data.json b/529/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a32f006225517a13a145bd527c42e6e54874a387 --- /dev/null +++ b/529/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "529", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/529/surgery_description.txt b/529/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..68c07b78d780aeb7f8418d948a38e8b4a87beca6 --- /dev/null +++ b/529/surgery_description.txt @@ -0,0 +1 @@ +frontolat. KK-Teilresektion n. Leroux-Robert diff --git a/529/surgery_report.txt b/529/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2fcbbade1e9066efea17498f98ab8e77420efbe7 --- /dev/null +++ b/529/surgery_report.txt @@ -0,0 +1 @@ +Active patient identification first. Carrying out the team time-out. Induction of anesthesia by anesthesia colleagues. Intubation via GlideScope, followed by pharyngoscopy and laryngoscopy using a size D Kleinsasser tube. The main tumor mass is seen in the anterior third of the right vocal fold with slight extension into the right morgue sinus, there is no infiltration of the pocket folds on the right, caudal extension of approx. 0.5 to 1 cm towards the subglottic area, anterior infiltration of the anterior commissure can only be seen using the scope and infiltration of the left vocal fold to approx. the middle, here strictly glottic growth without supra- or subglottic extension. Due to the poor adjustability, confirmation of the indication for transcervical partial laryngectomy. Positioning, skin spray disinfection, application of 6 ml xylocaine with added adrenaline in the area of a skin fold at the level of the thyroid cartilage. Abjode and cover sterilely. Creation of an approx. 4 cm long skin incision horizontally cutting through the subcutaneous tissue and the platysma. Creation of a subplatysmal skin flap cranially and caudally up to the level of the thyroid incisura and the cricoid cartilage. Exposure of the prelaryngeal musculature, splitting of the same in the linea alba. Exposure of the crycothyroid membrane and the ligamentum conicum. Incision of the perichondrium in the midline and removal of cartilage laterally on both sides. Then horizontal incision of the ligamentum conicum and opening of the laryngeal lumen subglottically. Paramedian thyrotomy in the midline using a wheel and opening of the laryngeal lumen at the supraglottic level. Inspection of the findings from the cranial side and subsequent subperichondral dissection on the left side, including the endochondrium of the thyroid cartilage. Cut around the tumor specimen on the left side with sufficient safety distance macroscopically in sano supra- and subglottic and place posteriorly in the direction of the vocal process on approx. 1/2 length of the vocal fold. The preparation is marked with a suture and placed in the midline, meticulous hemostasis by bipolar coagulation. If the blood is dry, turn to the opposite side. Here also subperichondral dissection as far as subglottic and cranial to the beginning of the pocket crease. Subglottic and supraglottic dissection macroscopically in sano and posterior dissection taking the vocalis muscle towards the depth and posterior dissection at the vocal process, sparing the arytenoid cartilage. Now take 8 marginal samples in all directions, all marginal samples are found to be tumor-free by the pathology colleagues during the frozen section examination. Hemostasis in the resection area. Subsequent creation of 4 drill holes on the thyroid cartilage, insertion and suturing of a Keel in the midline, fixation of the Keel and adaptation of the cartilage surfaces using Vicryl 3-0 sutures. Subsequent suture adaptation of the ligamentum conicum, folding back the perichondrium leaves over the Keel. Creation of a prelaryngeal flap, suture adaptation of the prelaryngeal musculature in the midline in 2 layers. Subcutaneous suture and single button skin suture, application of a pressure bandage and completion of the procedure without complications. The patient received preoperative single shot antibiotics with ceftriaxone 2 g intravenously. Conclusion: Frontolateral partial laryngectomy according to Leroux-Robert for cT2 cN0 glottic laryngeal carcinoma, right-sided, in the frozen section examination and macroscopically in sano. Please note final histology. Vocal rest recommended for 5 days. Please plan control MLE and Keel removal in 6-8 weeks. \ No newline at end of file diff --git a/530/InvasionFront_CD3_block1_x5_y1_patient530_0.json b/530/InvasionFront_CD3_block1_x5_y1_patient530_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42b9a73fbbd5458445707366d2d324b8f67751d9 --- /dev/null +++ b/530/InvasionFront_CD3_block1_x5_y1_patient530_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16966.0, + "Centroid Y µm": 4172.8, + "Num Detections": 22475, + "Num Negative": 21632, + "Num Positive": 843, + "Positive %": 3.751, + "Num Positive per mm^2": 361.76 + } +} \ No newline at end of file diff --git a/530/InvasionFront_CD3_block1_x6_y1_patient530_1.json b/530/InvasionFront_CD3_block1_x6_y1_patient530_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65ec047cb09376fd5d3ab3d3bb475fe469204601 --- /dev/null +++ b/530/InvasionFront_CD3_block1_x6_y1_patient530_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19414.7, + "Centroid Y µm": 4347.7, + "Num Detections": 21381, + "Num Negative": 20866, + "Num Positive": 515, + "Positive %": 2.409, + "Num Positive per mm^2": 214.85 + } +} \ No newline at end of file diff --git a/530/InvasionFront_CD8_block1_x5_y1_patient530_0.json b/530/InvasionFront_CD8_block1_x5_y1_patient530_0.json new file mode 100644 index 0000000000000000000000000000000000000000..abfed731f7ae0a1b9f31fc23c6d303e557284740 --- /dev/null +++ b/530/InvasionFront_CD8_block1_x5_y1_patient530_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17165.9, + "Centroid Y µm": 2848.5, + "Num Detections": 20485, + "Num Negative": 18638, + "Num Positive": 1847, + "Positive %": 9.016, + "Num Positive per mm^2": 883.26 + } +} \ No newline at end of file diff --git a/530/InvasionFront_CD8_block1_x6_y1_patient530_1.json b/530/InvasionFront_CD8_block1_x6_y1_patient530_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8dfeac415c32ef4321d207cd379f5c248bcceabd --- /dev/null +++ b/530/InvasionFront_CD8_block1_x6_y1_patient530_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19839.5, + "Centroid Y µm": 3098.4, + "Num Detections": 24159, + "Num Negative": 22277, + "Num Positive": 1882, + "Positive %": 7.79, + "Num Positive per mm^2": 794.8 + } +} \ No newline at end of file diff --git a/530/TumorCenter_CD3_block1_x5_y2_patient530_0.json b/530/TumorCenter_CD3_block1_x5_y2_patient530_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1189cc94f726997156cfd7d65e087dc0982f439c --- /dev/null +++ b/530/TumorCenter_CD3_block1_x5_y2_patient530_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15216.9, + "Centroid Y µm": 5172.3, + "Num Detections": 21825, + "Num Negative": 21258, + "Num Positive": 567, + "Positive %": 2.598, + "Num Positive per mm^2": 225.04 + } +} \ No newline at end of file diff --git a/530/TumorCenter_CD3_block1_x6_y2_patient530_1.json b/530/TumorCenter_CD3_block1_x6_y2_patient530_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a1c5e5507a0a5f71eda315fc99e342a9ad51c5c2 --- /dev/null +++ b/530/TumorCenter_CD3_block1_x6_y2_patient530_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17690.6, + "Centroid Y µm": 4922.4, + "Num Detections": 21754, + "Num Negative": 20432, + "Num Positive": 1322, + "Positive %": 6.077, + "Num Positive per mm^2": 568.65 + } +} \ No newline at end of file diff --git a/530/TumorCenter_CD8_block1_x5_y1_patient530_0.json b/530/TumorCenter_CD8_block1_x5_y1_patient530_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f65ee3d484da0c5076d43ac360d06dc0d71fe914 --- /dev/null +++ b/530/TumorCenter_CD8_block1_x5_y1_patient530_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 11394.0, + "Num Detections": 15379, + "Num Negative": 14570, + "Num Positive": 809, + "Positive %": 5.26, + "Num Positive per mm^2": 510.56 + } +} \ No newline at end of file diff --git a/530/TumorCenter_CD8_block1_x6_y1_patient530_1.json b/530/TumorCenter_CD8_block1_x6_y1_patient530_1.json new file mode 100644 index 0000000000000000000000000000000000000000..20fbec5e597a9e4751ca704af761028b7cb0cd8a --- /dev/null +++ b/530/TumorCenter_CD8_block1_x6_y1_patient530_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21413.7, + "Centroid Y µm": 11419.0, + "Num Detections": 12180, + "Num Negative": 11066, + "Num Positive": 1114, + "Positive %": 9.146, + "Num Positive per mm^2": 864.77 + } +} \ No newline at end of file diff --git a/530/history_text.txt b/530/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/530/icd_codes.txt b/530/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/530/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/530/ops_codes.txt b/530/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..eb1435769b1cf986a646c7855f3dcfc36b2358b6 --- /dev/null +++ b/530/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheostomaanlage[5-312.0 ] Anlegen und Wechsel einer duodenalen oder jejunalen Ernährungssonde über eine liegende PEG-Sonde, endoskopisch[8-125.2 ] \ No newline at end of file diff --git a/530/patient_clinical_data.json b/530/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..73e39e0639add3cc64fb40c597e1deee700f464b --- /dev/null +++ b/530/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/530/patient_pathological_data.json b/530/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..eb2e175d52284bb68ba489222d4ecfd1c93b7395 --- /dev/null +++ b/530/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "530", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 51, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/530/surgery_description.txt b/530/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b0df65a25b21d15b293d5ecebe1a1ddbe69cc88a --- /dev/null +++ b/530/surgery_description.txt @@ -0,0 +1 @@ +Transorale Tumorresektion, funkt. Neck dissection, Tracheotomie, Freier Lappen (Radialis) diff --git a/530/surgery_report.txt b/530/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6b966e5ab0dd6f1cd9497e37ba50fd30d0b6706a --- /dev/null +++ b/530/surgery_report.txt @@ -0,0 +1 @@ +After preparation, first place the PEG tube in the typical manner. Then perform the tracheotomy through and between the 2nd and 3rd tracheal cartilage. Re-intubation of the patient. Now first transoral tumor resection. After appropriate adjustment with the tonsil retractor, the tumor is resected with the monopolar caustic. Part of the soft palate on the left side or the uvula is resected. Laterally, the resection reaches the mandibular branch. Dorsally and medially, the tumor is successively resected in healthy muscle tissue. The resection continues into the glossotonsillar groove, which appears inconspicuous macroscopically. After removal of the tumor, peripheral incisions are made circumferentially, all of which are found to be tumor-free on frozen section histology. The selective neck dissection is then performed on the left side. After making the apron flap incision and dissection upwards, fixation upwards in the usual manner. Then skeletonize the sternocleidomastoid muscle. A large metastasis is found here in region II, which can be successively removed in toto after skeletonization of the digastric muscle. After opening and skeletonizing the vascular nerve sheath, regions I-V are resected while preserving all non-lymphatic structures. The large caliber jugular vein and the superior thyroid artery are skeletonized, exposed and preserved and are later used for anastomosis of the microvascular radial lobe graft. Subsequent transition to the opposite side. Here, after the initial start by , the same procedure with similar findings. Here, too, there is a mass in region II, albeit a smaller one, which is suspected to be metastatic. The hypoglossal nerve is then exposed on the left side and cut upwards. Dissection of the digastric muscle and creation of the pharyngotomy at the caudal resection margin of the transoral resection. Widen the access while protecting the lingual artery, the external carotid artery and the hypoglossal nerve. Lifting of the radialis graft by . Drawing of a graft in consultation with , who measured the defect 9 x 6 cm. Marking of the radial artery, the ulnar artery and the cephalic vein. Then unwrap the arm and apply a 300 mmHg tourniquet. Incision of the skin and exposure of the brachioradialis muscle. Exposure of the cephalic vein which can be integrated laterally into the graft. Then expose the superficial ramus of the radial nerve. Preservation of this nerve branch with all its additional branches. Exposure of the radial artery. Separation of the radial artery, lifting of the graft from the tendon bed and preparation in the usual manner up to the elbow. The radialis graft is then removed, taking with it the cephalic vein from the superficial system and the venous confluence and lifting a venous outflow from the deep venous system. The graft is then flushed with heparin and handed over to , who then sutures it in place. The defect is then covered with split skin from the right thigh in the usual way and the arm is closed in the usual way. The radial lobe graft is then inserted through the pharyngotomy into the resection defect. Fixation of the radial flap graft in the resection area. Subsequently, the microvascular anastomosis of the artery from the radial artery to the superior thyroid artery and the large-volume brachial vein to the facial vein is performed. The flap shows excellent perfusion on all sides. Application of a Redon drainage on both sides. Two-layer wound closure. Completion of the mucocutaneous anastomosis and transfer of the patient to an 8-gauge tracheostomy tube. Sterile wound dressing on both cervical sides. Transoral inspection of the flap from which bright red arterial blood runs out at the upper pole after puncture. End of the operation and transfer of the patient to anesthesia. Conclusion: partial oropharyngeal resection for tonsillar carcinoma on the left side. R0 resection on frozen section histology intraoperatively as well as macroscopically. Selective neck dissection on both sides. Defect coverage with microvascularly anastomosed radial artery flap graft from the left forearm and defect coverage on the left forearm with split skin from the right thigh. Arterial anastomosis to the superior thyroid vein and venous anastomosis to the facial vein. Creation of a PEG and a mucocutaneous tracheostoma. Intraoperative metastatic mass certainly on the left and also on the right, therefore adjuvant therapy is recommended postoperatively. \ No newline at end of file diff --git a/531/InvasionFront_CD3_block10_x5_y2_patient531_0.json b/531/InvasionFront_CD3_block10_x5_y2_patient531_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7b86a330a622db2f99978998a6034563be14bb27 --- /dev/null +++ b/531/InvasionFront_CD3_block10_x5_y2_patient531_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19239.8, + "Centroid Y µm": 10619.4, + "Num Detections": 21244, + "Num Negative": 21101, + "Num Positive": 143, + "Positive %": 0.6731, + "Num Positive per mm^2": 59.77 + } +} \ No newline at end of file diff --git a/531/InvasionFront_CD3_block10_x6_y2_patient531_1.json b/531/InvasionFront_CD3_block10_x6_y2_patient531_1.json new file mode 100644 index 0000000000000000000000000000000000000000..022764606f34f1071575419d5f29a7aad99a6a58 --- /dev/null +++ b/531/InvasionFront_CD3_block10_x6_y2_patient531_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21738.5, + "Centroid Y µm": 10694.3, + "Num Detections": 21165, + "Num Negative": 20797, + "Num Positive": 368, + "Positive %": 1.739, + "Num Positive per mm^2": 148.98 + } +} \ No newline at end of file diff --git a/531/InvasionFront_CD8_block10_x5_y2_patient531_0.json b/531/InvasionFront_CD8_block10_x5_y2_patient531_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f818fc9074f289583a95b90ed3a57dd3f4911a71 --- /dev/null +++ b/531/InvasionFront_CD8_block10_x5_y2_patient531_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18165.4, + "Centroid Y µm": 10569.4, + "Num Detections": 24676, + "Num Negative": 24570, + "Num Positive": 106, + "Positive %": 0.4296, + "Num Positive per mm^2": 43.38 + } +} \ No newline at end of file diff --git a/531/InvasionFront_CD8_block10_x6_y2_patient531_1.json b/531/InvasionFront_CD8_block10_x6_y2_patient531_1.json new file mode 100644 index 0000000000000000000000000000000000000000..db329a020b4f660690a26bf02f9baaa99f6f6d7b --- /dev/null +++ b/531/InvasionFront_CD8_block10_x6_y2_patient531_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20789.0, + "Centroid Y µm": 10694.3, + "Num Detections": 22925, + "Num Negative": 22586, + "Num Positive": 339, + "Positive %": 1.479, + "Num Positive per mm^2": 137.28 + } +} \ No newline at end of file diff --git a/531/TumorCenter_CD3_block10_x5_y2_patient531_0.json b/531/TumorCenter_CD3_block10_x5_y2_patient531_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d5b90ca002d73f3cda60e80710cc6e62138f2744 --- /dev/null +++ b/531/TumorCenter_CD3_block10_x5_y2_patient531_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18640.1, + "Centroid Y µm": 4822.4, + "Num Detections": 11508, + "Num Negative": 11423, + "Num Positive": 85, + "Positive %": 0.7386, + "Num Positive per mm^2": 58.15 + } +} \ No newline at end of file diff --git a/531/TumorCenter_CD3_block10_x6_y2_patient531_1.json b/531/TumorCenter_CD3_block10_x6_y2_patient531_1.json new file mode 100644 index 0000000000000000000000000000000000000000..058d83343b04411af459296c61c9da1ff888a4d9 --- /dev/null +++ b/531/TumorCenter_CD3_block10_x6_y2_patient531_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21263.7, + "Centroid Y µm": 4547.6, + "Num Detections": 18913, + "Num Negative": 18711, + "Num Positive": 202, + "Positive %": 1.068, + "Num Positive per mm^2": 82.37 + } +} \ No newline at end of file diff --git a/531/TumorCenter_CD8_block10_x5_y2_patient531_0.json b/531/TumorCenter_CD8_block10_x5_y2_patient531_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2d623ec364a228860d07181ae029c4690a2563de --- /dev/null +++ b/531/TumorCenter_CD8_block10_x5_y2_patient531_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15691.7, + "Centroid Y µm": 5322.2, + "Num Detections": 19499, + "Num Negative": 18961, + "Num Positive": 538, + "Positive %": 2.759, + "Num Positive per mm^2": 248.4 + } +} \ No newline at end of file diff --git a/531/TumorCenter_CD8_block10_x6_y2_patient531_1.json b/531/TumorCenter_CD8_block10_x6_y2_patient531_1.json new file mode 100644 index 0000000000000000000000000000000000000000..50840fdbc04c65d59187f654ad893fdf0f4fc34a --- /dev/null +++ b/531/TumorCenter_CD8_block10_x6_y2_patient531_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18190.4, + "Centroid Y µm": 4922.4, + "Num Detections": 22164, + "Num Negative": 21901, + "Num Positive": 263, + "Positive %": 1.187, + "Num Positive per mm^2": 109.62 + } +} \ No newline at end of file diff --git a/531/history_text.txt b/531/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/531/icd_codes.txt b/531/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/531/ops_codes.txt b/531/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15a51541cf1f70384d38f017657d63ca9252b7dd --- /dev/null +++ b/531/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie: Transoral: Sonstige[5-251.0x ] Exzision und Destruktion einer Zungengrundtonsille: Transoral[5-284.0 ] Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Rekonstruktion mit lokaler Schleimhaut[5-295.01 ] Permanente Tracheostomie: Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/531/patient_clinical_data.json b/531/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f8f38088cd0c5fcbecee959bb802e300ad2c05eb --- /dev/null +++ b/531/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/531/patient_pathological_data.json b/531/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b7bec22d42ab3460a0e639b09503e88f535a7106 --- /dev/null +++ b/531/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "531", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "Mucoepidermoid_Carcinoma", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/531/surgery_description.txt b/531/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2f72803a9cd2ff673c263e29e13c7b8d194b8bee --- /dev/null +++ b/531/surgery_description.txt @@ -0,0 +1 @@ +Transorale Tumorresektion mittels TORS diff --git a/531/surgery_report.txt b/531/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ba4b4b3bac13cd8aa4616221da50f819db90b68c --- /dev/null +++ b/531/surgery_report.txt @@ -0,0 +1 @@ +After intubation anesthesia of the patient, initial inspection of the oral cavity, oropharynx and hypopharynx with the Kleinsasser tube. This reveals a spherical mass in the area of the base of the tongue, which is covered by smooth mucosa, with otherwise normal, inconspicuous mucosal conditions and a relatively narrow pharynx. Then reposition the patient and insert the Fentex retractor and expose the base of the tongue. Extremely difficult to adjust here. In the end, however, it was possible to expose the tumor completely. Then insertion of the robotic instruments. Start the resection tangentially at the base of the tongue so that the tumor can be excised circularly with a sufficient safety distance to the tumor. This is done using monopolar coagulation and subtle hemostasis. Several marginal samples are then taken and sent in as frozen sections for histopathological tissue examination. These are found to be tumor-free intraoperatively. Subtle hemostasis again. Then removal of the robotic instruments and the Fentex retractor. Due to significant swelling in the area of the entire hypopharynx, the decision was made to tracheostomy the patient after he could only be intubated bronchoscopically by the anesthesia colleagues. This measure is carried out as a protective intubation. The patient is then repositioned, the neck is abducted and local anesthetic with adrenaline is injected. Then pretracheal skin incision and layered preparation in depth. Dissection of the pretracheal muscles in the midline, which is then dissected to the side. Exposure of the thyroid isthmus. This is undermined and dissected after careful coagulation. Exposure of the anterior surface of the trachea. Then incision of the trachea between the 2nd and 3rd cartilage clasp. Preparation of a Björk flap. Then circular suturing of the trachea in the sense of anastomosis to the skin. Then insertion of an 8-bore tracheostomy tube through which the patient can initially continue to be ventilated without any problems. The procedure is then completed. Repeated enoral bleeding control, here dry wound conditions. The decision was therefore made to end the procedure and allow the patient to wake up, which was done without any problems. Further procedure depending on the result of the histopathological examination. \ No newline at end of file diff --git a/532/InvasionFront_CD3_block21_x1_y5_patient532_0.json b/532/InvasionFront_CD3_block21_x1_y5_patient532_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8df95fbcde924046500d523008cde4a8e3f26422 --- /dev/null +++ b/532/InvasionFront_CD3_block21_x1_y5_patient532_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 22463.1, + "Num Detections": 24908, + "Num Negative": 22636, + "Num Positive": 2272, + "Positive %": 9.122, + "Num Positive per mm^2": 905.03 + } +} \ No newline at end of file diff --git a/532/InvasionFront_CD3_block21_x2_y5_patient532_1.json b/532/InvasionFront_CD3_block21_x2_y5_patient532_1.json new file mode 100644 index 0000000000000000000000000000000000000000..94f6a598c4db6960921ad324788daca5c8cd832b --- /dev/null +++ b/532/InvasionFront_CD3_block21_x2_y5_patient532_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9020.2, + "Centroid Y µm": 22663.0, + "Num Detections": 28925, + "Num Negative": 26703, + "Num Positive": 2222, + "Positive %": 7.682, + "Num Positive per mm^2": 818.16 + } +} \ No newline at end of file diff --git a/532/InvasionFront_CD8_block21_x1_y5_patient532_0.json b/532/InvasionFront_CD8_block21_x1_y5_patient532_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f8626b89d722b7301806707ff4757904d763b8c9 --- /dev/null +++ b/532/InvasionFront_CD8_block21_x1_y5_patient532_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 12218.5, + "Num Detections": 24223, + "Num Negative": 20665, + "Num Positive": 3558, + "Positive %": 14.69, + "Num Positive per mm^2": 1447.9 + } +} \ No newline at end of file diff --git a/532/InvasionFront_CD8_block21_x2_y5_patient532_1.json b/532/InvasionFront_CD8_block21_x2_y5_patient532_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3f4fd474de1e02ae8eb9e961d2ea53e96bf97812 --- /dev/null +++ b/532/InvasionFront_CD8_block21_x2_y5_patient532_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 12268.5, + "Num Detections": 29752, + "Num Negative": 26153, + "Num Positive": 3599, + "Positive %": 12.1, + "Num Positive per mm^2": 1309.3 + } +} \ No newline at end of file diff --git a/532/TumorCenter_CD3_block21_x1_y5_patient532_0.json b/532/TumorCenter_CD3_block21_x1_y5_patient532_0.json new file mode 100644 index 0000000000000000000000000000000000000000..098d8fddbf45f27b4c1acef5f803efd04592fe79 --- /dev/null +++ b/532/TumorCenter_CD3_block21_x1_y5_patient532_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3248.3, + "Centroid Y µm": 15366.9, + "Num Detections": 25030, + "Num Negative": 24264, + "Num Positive": 766, + "Positive %": 3.06, + "Num Positive per mm^2": 281.2 + } +} \ No newline at end of file diff --git a/532/TumorCenter_CD3_block21_x2_y5_patient532_1.json b/532/TumorCenter_CD3_block21_x2_y5_patient532_1.json new file mode 100644 index 0000000000000000000000000000000000000000..683cf9013579b64d169f1389e8725979dbbddf2f --- /dev/null +++ b/532/TumorCenter_CD3_block21_x2_y5_patient532_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5896.9, + "Centroid Y µm": 15316.9, + "Num Detections": 22882, + "Num Negative": 21645, + "Num Positive": 1237, + "Positive %": 5.406, + "Num Positive per mm^2": 480.98 + } +} \ No newline at end of file diff --git a/532/TumorCenter_CD8_block21_x1_y5_patient532_0.json b/532/TumorCenter_CD8_block21_x1_y5_patient532_0.json new file mode 100644 index 0000000000000000000000000000000000000000..13f1ed5cd214554fbc209e5a9c313bde0a35dca2 --- /dev/null +++ b/532/TumorCenter_CD8_block21_x1_y5_patient532_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5946.9, + "Centroid Y µm": 27135.6, + "Num Detections": 24725, + "Num Negative": 22656, + "Num Positive": 2069, + "Positive %": 8.368, + "Num Positive per mm^2": 756.84 + } +} \ No newline at end of file diff --git a/532/TumorCenter_CD8_block21_x2_y5_patient532_1.json b/532/TumorCenter_CD8_block21_x2_y5_patient532_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e1c5ee2789870ff2190eae6bf8a71170015a7984 --- /dev/null +++ b/532/TumorCenter_CD8_block21_x2_y5_patient532_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8545.5, + "Centroid Y µm": 27285.6, + "Num Detections": 23928, + "Num Negative": 21592, + "Num Positive": 2336, + "Positive %": 9.763, + "Num Positive per mm^2": 904.39 + } +} \ No newline at end of file diff --git a/532/history_text.txt b/532/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..015598895cd65658f51b830b64254dd32d39bb6a --- /dev/null +++ b/532/history_text.txt @@ -0,0 +1 @@ + has a histologically confirmed G2 squamous cell carcinoma of the left aryepiglottic fold. In addition, there is a 4 ˝ cm lymph node metastasis on the left with infiltration of the sternocleidomastoid muscle and the internal jugular vein. Therefore indication for the above-mentioned operation. \ No newline at end of file diff --git a/532/icd_codes.txt b/532/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b2b94cb50933cfa2488a2941aa728866a25f7e3 --- /dev/null +++ b/532/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 ] \ No newline at end of file diff --git a/532/ops_codes.txt b/532/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9aa1ea8b8746cb76eb0e443d543b98c252866e3c --- /dev/null +++ b/532/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] Mikrolaryngoskopische Exzision am Larynx[5-300.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Anlegen einer PEG[5-431.2 ] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] \ No newline at end of file diff --git a/532/patient_clinical_data.json b/532/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cd4049cc73aa1b3899c100d6289d85dd0e28de0d --- /dev/null +++ b/532/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 41, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/532/patient_pathological_data.json b/532/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2d314449e9ce87841fcb8343ec0b2b7e6ad9cae7 --- /dev/null +++ b/532/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "532", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 54, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/532/surgery_description.txt b/532/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0935d3a5810f6514e4e3e6067aa8b88f471e109b --- /dev/null +++ b/532/surgery_description.txt @@ -0,0 +1 @@ +Laserresektion, Neck diss., PEG-Anlage diff --git a/532/surgery_report.txt b/532/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4cf4cdc6bb14d9d35b1719f8d31ac97a642e8baa --- /dev/null +++ b/532/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthetist, 3 g of Unacid is administered preemptively. Flexible esophagogastroscopy is then performed under constant air insufflation. After positive diaphanoscopy, insertion of the trocar and placement of the PEG tube using the thread pull-through method in the typical manner. The tumor is now positioned with the spread laryngoscope. The left aryepiglottic fold is found to be about 1 cm wider, thickened and uneven without clearly exophytic tumor growth. Under the microscope, however, the clearly uneven mucosa is visible. The mass does not infiltrate the arytenoid cartilage and extends both endolaryngeally and towards the median piriform sinus wall over a width of approx. 5 mm. Cranially and anteriorly, it reaches the aryepiglottic fold without actually infiltrating the lateral side. Demonstration of the findings to , who approves the procedure. Now the resection is started with the CO2 laser at 4 watts and continues mode, initially on the median side and at the border to the arytenoid cartilage. Then laterally over the base of the epiglottis into the pharyngoepiglottic fold. Laterally, the anterior piriform sinus wall is also resected in the entrance area of the piriform sinus and then the resection is completed along the median piriform sinus wall with a safety margin of approx. 5 mm. During the resection, a small arterial hemorrhage occurs once, which can be easily stopped using monopolar coagulation. After careful consideration of the tumor specimen, a decision is made to perform another small resection in the anterior and cranial area of the pharyngoepiglottic fold/laryngeal epiglottis junction. This is also done with the laser. Now, after consultation with , several marginal samples are taken: 1x medial to the aryepiglottic fold/transition pocket fold, 1x anterior cranial along the pharyngoepiglottic fold, the 3rd starting from the arytenoid cartilage over the median piriform sinus wall to the lateral and the 4th in the area of the wound bed. The frozen section diagnosis reveals mild to moderate dysplasia in the area of the median piriform sinus wall. A resection is therefore carried out in this area if the mucosa is normal and sent for frozen section diagnostics. A resection is also performed in the area of the median aryepiglottic fold/transition pocket fold if the mucosa is slightly suspicious under the microscope. The 2nd frozen section diagnosis now reveals non-irritant conditions in the area of the median piriform sinus wall, but a tiny carcinoma in situ in the area of the median aryepiglottic fold/pocket fold junction. Therefore, a second resection is performed here, which is sent for final histology and a second marginal sample of the aryepiglottic fold in the median direction. In between, neck dissection level I b to V b is performed on the left side, which involves partial resection of the sternocleidomastoid muscle and resection of the internal jugular vein and facial vein. Initial curved skin incision along the sternocleidomastoid muscle. Dissection through the platysma. Protect the external jugular vein. Now attempt to dissect the anterior border of the sternocleidomastoid muscle. However, it quickly becomes apparent that this is cemented to the tumor conglomerate, but only in the central area. The anterior margin is therefore exposed in the caudal and cranial area and a partial resection of the sternocleidomastoid muscle is performed in the central area. The resection is then continued subglottismal to anterior, then the omohyoid muscle is followed posteriorly to anterior without the digastric venter muscle. The submandibular gland is skeletonized. In addition, the facial vein is identified and ligated. Then identify the hypoglossal nerve and the superior laryngeal nerve and form the preparation from median to lateral. The thyroid gland and the deep laryngeal musculature are visualized in the caudal region. Now expose the internal jugular vein cranially and caudally of the tumor conglomerate. This is relatively small and without a lumen, so that a thrombosis of the vein must be suspected. It was therefore decided to resect and ligate the internal jugular vein in its cranial and caudal insertion. Now dissect along the common carotid artery from median to lateral. It can be seen that the tumor conglomerate can be easily pushed away from the carotid artery. In addition, identify the vagus nerve and spare the last one. Now laterally expose the scalene musculature. Identify the accessorius nerve, which can be spared, and complete the neck dissection in its lateral section from cranial to lateral while sparing the plexus branches and the accessorius nerve. In the deep caudal area, care is taken to resect level II b as well. Now careful hemostasis. Placement of a 10 Redon drain and two-layer wound closure using subcutaneous and skin sutures. After consultation with , a temporary plastic tracheotomy is performed: horizontal incision approx. 1 cm caudal to the cricoid cartilage. Dissection through subcutaneous tissue and platysma. Exposure of pretracheal musculature. Spreading in the linea alba. Identification of the thyroid isthmus and undermining. Bipolization of the thyroid isthmus and spreading of the trachea. Opening of the trachea between the 2nd and 3rd tracheal ring and epithelialization of the slit-shaped opening in the sense of a visor tracheotomy. Re-intubation with an 8 mm Rügheimer cannula. Now proceed to neck dissection of the right side selectively level II to IV. Dissection through subcutaneous tissue and platysma. Expose the sternocleidomastoid muscle, the digastric muscle and the omohyoid muscle. Identification and protection of the accessorius nerve. Dissect the internal jugular vein from caudal to cranial and expose the facial vein and, after isolating the cervical vascular sheath, form the lateral neck preparation from cranial to caudal while sparing the plexus branches and the accessory nerve. This is followed by resection above the venous angle after identification of the hypoglossal nerve and finally removal of the median neck preparation caudal to the facial vein. Hemostasis by means of bipolar coagulation. Irrigation with hydrogen and Ringer. Placement of a 10 Redon drain and two-layer wound closure. The final frozen section diagnosis now results in an R0 resection, meaning completion of the procedure without bleeding and without complications. Conclusion: cT1 cN2b supraglottic laryngeal carcinoma of the left side, which was laser resected R0. Intraoperative administration of Unacid, which should be continued for 3 days. The patient should not be given any oral food for 1 week and then the cannula could be removed after a swallowing attempt. \ No newline at end of file diff --git a/533/InvasionFront_CD3_block21_x1_y1_patient533_0.json b/533/InvasionFront_CD3_block21_x1_y1_patient533_0.json new file mode 100644 index 0000000000000000000000000000000000000000..36689019aefa37377b345245a806bec4c218c3a8 --- /dev/null +++ b/533/InvasionFront_CD3_block21_x1_y1_patient533_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6946.3, + "Centroid Y µm": 12468.4, + "Num Detections": 21735, + "Num Negative": 19674, + "Num Positive": 2061, + "Positive %": 9.482, + "Num Positive per mm^2": 815.43 + } +} \ No newline at end of file diff --git a/533/InvasionFront_CD3_block21_x2_y1_patient533_1.json b/533/InvasionFront_CD3_block21_x2_y1_patient533_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2dfbb96c0bb898932fe532d40593d3ad2a7abfd5 --- /dev/null +++ b/533/InvasionFront_CD3_block21_x2_y1_patient533_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9594.9, + "Centroid Y µm": 12693.3, + "Num Detections": 20034, + "Num Negative": 17522, + "Num Positive": 2512, + "Positive %": 12.54, + "Num Positive per mm^2": 988.29 + } +} \ No newline at end of file diff --git a/533/InvasionFront_CD8_block21_x1_y1_patient533_0.json b/533/InvasionFront_CD8_block21_x1_y1_patient533_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0cb6c45ab71a5e6723c3301ebe40f44ae23fae3b --- /dev/null +++ b/533/InvasionFront_CD8_block21_x1_y1_patient533_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3448.2, + "Centroid Y µm": 2473.7, + "Num Detections": 22934, + "Num Negative": 19069, + "Num Positive": 3865, + "Positive %": 16.85, + "Num Positive per mm^2": 1471.5 + } +} \ No newline at end of file diff --git a/533/InvasionFront_CD8_block21_x2_y1_patient533_1.json b/533/InvasionFront_CD8_block21_x2_y1_patient533_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4c86b9bc80ccfecb398db2f325f7166bcb29bd11 --- /dev/null +++ b/533/InvasionFront_CD8_block21_x2_y1_patient533_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 2523.7, + "Num Detections": 22002, + "Num Negative": 19768, + "Num Positive": 2234, + "Positive %": 10.15, + "Num Positive per mm^2": 837.81 + } +} \ No newline at end of file diff --git a/533/TumorCenter_CD3_block21_x1_y1_patient533_0.json b/533/TumorCenter_CD3_block21_x1_y1_patient533_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f58a85f5a04b174d22984487453c63f07ad0487d --- /dev/null +++ b/533/TumorCenter_CD3_block21_x1_y1_patient533_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 2923.5, + "Centroid Y µm": 4597.6, + "Num Detections": 19502, + "Num Negative": 18633, + "Num Positive": 869, + "Positive %": 4.456, + "Num Positive per mm^2": 358.55 + } +} \ No newline at end of file diff --git a/533/TumorCenter_CD3_block21_x2_y1_patient533_1.json b/533/TumorCenter_CD3_block21_x2_y1_patient533_1.json new file mode 100644 index 0000000000000000000000000000000000000000..31f5b90313f0ec787ac0bca988708180b7615cfb --- /dev/null +++ b/533/TumorCenter_CD3_block21_x2_y1_patient533_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5497.1, + "Centroid Y µm": 4722.5, + "Num Detections": 20497, + "Num Negative": 19389, + "Num Positive": 1108, + "Positive %": 5.406, + "Num Positive per mm^2": 448.15 + } +} \ No newline at end of file diff --git a/533/TumorCenter_CD8_block21_x1_y1_patient533_0.json b/533/TumorCenter_CD8_block21_x1_y1_patient533_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1d5aa2c64c209d6f3916832e7aaa337bc0376f3a --- /dev/null +++ b/533/TumorCenter_CD8_block21_x1_y1_patient533_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 17066.0, + "Num Detections": 20593, + "Num Negative": 18496, + "Num Positive": 2097, + "Positive %": 10.18, + "Num Positive per mm^2": 853.1 + } +} \ No newline at end of file diff --git a/533/TumorCenter_CD8_block21_x2_y1_patient533_1.json b/533/TumorCenter_CD8_block21_x2_y1_patient533_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6076209b2e09de7e883b3e9d9692f632abcdcb29 --- /dev/null +++ b/533/TumorCenter_CD8_block21_x2_y1_patient533_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8895.3, + "Centroid Y µm": 17390.8, + "Num Detections": 18031, + "Num Negative": 16569, + "Num Positive": 1462, + "Positive %": 8.108, + "Num Positive per mm^2": 668.38 + } +} \ No newline at end of file diff --git a/533/history_text.txt b/533/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..efb912f2f7f18e9f888e5f6f6f03661e4fe53a75 --- /dev/null +++ b/533/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed glottic carcinoma originating from the right, very difficult setting and spread via the opposite side and in the direction of the supraglottis, above-mentioned surgery indicated as an external approach. \ No newline at end of file diff --git a/533/icd_codes.txt b/533/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc6fd121dc40d22b6fb46d31a947332bc01b0c9d --- /dev/null +++ b/533/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/533/ops_codes.txt b/533/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f22a659413527e2bb2c9263d0cec81b11bd9b640 --- /dev/null +++ b/533/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] Sonstige diagnostische Tracheobronchoskopie[1-620.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 4 Regionen[5-403.30 B] Permanente Tracheotomie[5-312.0 ] Resektion Nase partiell[5-213.0 ] \ No newline at end of file diff --git a/533/patient_clinical_data.json b/533/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..acad4d2955372492aecf8b3bde03c7c61542a4a7 --- /dev/null +++ b/533/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 83, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 54, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/533/patient_pathological_data.json b/533/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..99e257e417452e3d80d33b72b03962d186cb4d6c --- /dev/null +++ b/533/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "533", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/533/surgery_description.txt b/533/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7cdfc88923fec42a65d0fe46b917615304296930 --- /dev/null +++ b/533/surgery_description.txt @@ -0,0 +1 @@ +Kehlkopfteilresektion, Neck dissection, Tracheotomie diff --git a/533/surgery_report.txt b/533/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ee2b6ae21bbec8435c3cc5fcdab1542808a749b6 --- /dev/null +++ b/533/surgery_report.txt @@ -0,0 +1 @@ +First, laryngoscopy and pharyngoscopy again: insertion of the mouth guard and insertion of the Kleinsasser tube size 10, the larynx is difficult to adjust. The exophytic tumor is seen, which does not quite reach the arytenoid region on the right and extends into the morgue sinus on the right and forward into the anterior commissure and from there into the left side. A tracheoscopy was performed beforehand. This showed no relevant growth towards the subglottic region. Subsequently, partial laryngectomy. Therefore, procedure now confirmed from the outside. This is followed by repositioning, surgery from the outside. Injection not possible due to age and previous illness. This is followed by the creation of an apron flap in a typical subplatysmal manner. In the case of adhesions on the right and after carotid TEA, this is much more difficult on this side. Then expose the larynx. Splitting of the infrahoyidal musculature. The perichondrium is now dissected from the left side and left undissected on the right side. Exposure of the thyroid cartilage. Splitting of the thyroid cartilage in the middle with a slightly protruding edge to the left. Entering the larynx. Exposure of the tumor. As described, this can be seen growing from the right over the commissure to the left up to half of the vocal fold on the left, also here growth in the direction of the morgue sinus. A triangle of the thyroid cartilage is resected in the front, the perichondrium is dissected away from the cartilage on both sides. The resection includes the pouch ligament on both sides and all soft tissue up to the cartilage. Resection extends as far as the arytenoid cartilage, which can, however, be almost completely preserved. On the left, the resection also extends to a few mm in front of the arytenoid cartilage. Caudally, the resection includes soft tissue up to the ligamentum conicum. Cranially in front up to the petiolus. Removal of the tumor. Removal of marginal samples from the arytenoid region on both sides, caudally on both sides, cranially supraglottically on both sides and in the subglottic direction at the border to the ligamentum conicum as an anterior marginal sample. All marginal samples free in the frozen section, thus R0 situation. Now irrigation of the wound area and careful hemostasis. Readaptation of the remaining thyroid cartilage despite losses on the left side at ......... Cartilage well possible after making 3 drill holes. A total of 3 Vicryl single-button sutures with stable adaptation were performed. The remaining perichondrium is wrapped around the thyroid cartilage again and sutured to the opposite side. The ligamentum conicum is also sutured and the perichondrium is sutured there so that a stable and complete closure is achieved. The infrahyoid musculature is then adapted. A tracheostomy had already been performed before the resection. Difficult anatomical conditions with a short neck overall and a relatively deep larynx and trachea. The thyroid gland is shown in the middle of the isthmus area. Undercut and clamped, severed and supplied with puncture ligatures. Trachea is exposed. Entering the 2nd/3rd intercartilaginous space. Creation of a wide pedicled modified Björk flap. Skin mobilization up to the prethoracic skin is necessary to achieve a relatively low-tension medialization of the stoma. Re-intubation and insertion of a laryngectomy tube. Due to the extent of the tumor, indication for selective neck dissection on both sides: start with the right side. Extremely scarred conditions here following carotid TEA. Difficult visualization of the cervical vascular sheath through the scar plates. Exposure of the internal jugular vein. Visualization of the common carotid artery, visualization of a clear kinking which extends towards the paralaryngeal area and the floor of the mouth. Exposure of the vagus nerve, hypoglossal nerve and accessorius nerve. Level II-IV evacuation follows. Branches of the cervical plexus are exposed and preserved. Neck dissection on the left side follows. Level II-IV evacuation in the same way as on the right side. The fatty tissue in front of the head skeleton is also removed as a level VI resection. Subsequent careful hemostasis on both sides. Wound closure in layers with insertion of a Redondra ring on both sides and epithelialization of the tracheostoma. Re-intubation and insertion of an 8-gauge tracheostomy tube. Completion of the procedure without complications. Overall extensive modified frontolateral partial laryngectomy according to Leroux Robert. Both arytenoid cartilages are almost completely intact on the right and completely intact on the left. Nutrition for a few days via the inserted feeding tube. After stabilization, attempted swallowing and, if necessary, swallowing training and, if necessary, diet build-up. In principle, given the extent of the tumor and the borderline resection situation, a control MLE in 8-12 weeks should be discussed. This can be combined with tracheostoma closure if necessary. \ No newline at end of file diff --git a/534/InvasionFront_CD3_block9_x5_y8_patient534_0.json b/534/InvasionFront_CD3_block9_x5_y8_patient534_0.json new file mode 100644 index 0000000000000000000000000000000000000000..28f78d2a8c31f2b17c1ec1c46c64e538d2916fc0 --- /dev/null +++ b/534/InvasionFront_CD3_block9_x5_y8_patient534_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17390.8, + "Centroid Y µm": 21138.8, + "Num Detections": 15920, + "Num Negative": 15680, + "Num Positive": 240, + "Positive %": 1.508, + "Num Positive per mm^2": 111.53 + } +} \ No newline at end of file diff --git a/534/InvasionFront_CD3_block9_x6_y8_patient534_1.json b/534/InvasionFront_CD3_block9_x6_y8_patient534_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b06bbf90f82a86b4dc068c006b77e90787af5602 --- /dev/null +++ b/534/InvasionFront_CD3_block9_x6_y8_patient534_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20089.4, + "Centroid Y µm": 21313.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/534/InvasionFront_CD8_block9_x5_y8_patient534_0.json b/534/InvasionFront_CD8_block9_x5_y8_patient534_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3597aec23e40d89bc1ddff15140b99440b988ca0 --- /dev/null +++ b/534/InvasionFront_CD8_block9_x5_y8_patient534_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17390.8, + "Centroid Y µm": 24711.9, + "Num Detections": 16792, + "Num Negative": 16524, + "Num Positive": 268, + "Positive %": 1.596, + "Num Positive per mm^2": 126.48 + } +} \ No newline at end of file diff --git a/534/InvasionFront_CD8_block9_x6_y8_patient534_1.json b/534/InvasionFront_CD8_block9_x6_y8_patient534_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9bbcb9e6efef3a3e836958b71f514ef11b1aa08 --- /dev/null +++ b/534/InvasionFront_CD8_block9_x6_y8_patient534_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 24761.9, + "Num Detections": 10151, + "Num Negative": 9509, + "Num Positive": 642, + "Positive %": 6.325, + "Num Positive per mm^2": 530.92 + } +} \ No newline at end of file diff --git a/534/TumorCenter_CD3_block9_x5_y8_patient534_0.json b/534/TumorCenter_CD3_block9_x5_y8_patient534_0.json new file mode 100644 index 0000000000000000000000000000000000000000..26933d84ca618c8c2be74f37ce0b77e12211fa4b --- /dev/null +++ b/534/TumorCenter_CD3_block9_x5_y8_patient534_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 25811.3, + "Num Detections": 15678, + "Num Negative": 14919, + "Num Positive": 759, + "Positive %": 4.841, + "Num Positive per mm^2": 359.21 + } +} \ No newline at end of file diff --git a/534/TumorCenter_CD3_block9_x6_y8_patient534_1.json b/534/TumorCenter_CD3_block9_x6_y8_patient534_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a226b8202fe8712be9b028f6e1474ed1e7ddad86 --- /dev/null +++ b/534/TumorCenter_CD3_block9_x6_y8_patient534_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 25911.3, + "Num Detections": 19248, + "Num Negative": 18464, + "Num Positive": 784, + "Positive %": 4.073, + "Num Positive per mm^2": 336.77 + } +} \ No newline at end of file diff --git a/534/TumorCenter_CD8_block9_x5_y8_patient534_0.json b/534/TumorCenter_CD8_block9_x5_y8_patient534_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b68fdb9d5a9143fe285a9dbe47ad607f215ab949 --- /dev/null +++ b/534/TumorCenter_CD8_block9_x5_y8_patient534_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16816.1, + "Centroid Y µm": 21101.3, + "Num Detections": 8550, + "Num Negative": 8417, + "Num Positive": 133, + "Positive %": 1.556, + "Num Positive per mm^2": 113.18 + } +} \ No newline at end of file diff --git a/534/TumorCenter_CD8_block9_x6_y8_patient534_1.json b/534/TumorCenter_CD8_block9_x6_y8_patient534_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b21b8109ef5efd35cb9fbb5be9cad261255e04e9 --- /dev/null +++ b/534/TumorCenter_CD8_block9_x6_y8_patient534_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19317.9, + "Centroid Y µm": 20825.1, + "Num Detections": 17597, + "Num Negative": 17068, + "Num Positive": 529, + "Positive %": 3.006, + "Num Positive per mm^2": 247.86 + } +} \ No newline at end of file diff --git a/534/history_text.txt b/534/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f27936bdb9ea780e2edfc93c5bbd3417af2b16ec --- /dev/null +++ b/534/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT3 cN2c oropharyngeal carcinoma on the right with infiltration of the opposite side was histologically confirmed as a poorly differentiated squamous cell carcinoma during a panendoscopy <2014>. Computed tomography showed no evidence of distant metastasis. In our interdisciplinary tumor conference, the primary surgical procedure was decided. \ No newline at end of file diff --git a/534/icd_codes.txt b/534/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/534/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/534/ops_codes.txt b/534/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fda169ad68530738fb35efce00e77fb59504b19f --- /dev/null +++ b/534/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 B] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.48 R] Permanente Tracheotomie[5-312.0 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] \ No newline at end of file diff --git a/534/patient_clinical_data.json b/534/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..426dcdf1a715c66d04e44cc9e4e2c27726a8359c --- /dev/null +++ b/534/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 45, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/534/patient_pathological_data.json b/534/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0cc3755ebe70cf4abedc1188961ab3d49b2a2709 --- /dev/null +++ b/534/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "534", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/534/surgery_description.txt b/534/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f13cda4018c9847f7ec15f25c49a541e2743f6c2 --- /dev/null +++ b/534/surgery_description.txt @@ -0,0 +1 @@ +Resektion, Neck diss., Defektdeckung, Freier Lappen (ALT), Tracheotomie diff --git a/534/surgery_report.txt b/534/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..415f4f4b29fb4a79b41cfab98c626c999d2e5d69 --- /dev/null +++ b/534/surgery_report.txt @@ -0,0 +1 @@ +First, after preparation by the anesthesia colleagues, the primary tumor region is inspected. An ulcerated tumor is found in the area of the soft palate with a depleted uvula. Infiltration of the right tonsil. Here infiltration beyond the tonsil capsule, laterally. The caudal tonsil pole is exceeded by palpation. In addition, clear infiltration on the right side of the posterior palatal arch up to the transition to the posterior pharyngeal wall. On the left side, the carcinoma moves to the left tonsil, does not infiltrate it palpatorily via the hianus capsule, but here too there is clear infiltration of the posterior palatal arch, also with transition to the posterior pharyngeal wall. The transoral procedure is now performed. Incision in the area of the mucosal level of the tumor with subtotal removal of the soft palate. Complete removal of the anterior left palatal arch in the sense of a tumor tonsillectomy. Release of the tonsil at the lower tonsil pole. No transgression of the tonsil capsule laterally, safe basal conditions here. Inclusion of the posterior palatal arch. Resection up to the posterior pharyngeal wall is necessary. Right-sided extended resection. Resection up to the parapharyngeal soft tissue of the neck. This ensures safe conditions basally. Resection caudally up to the entrance of the piriform sinus. Resection of the posterior palatal arch also up to the posterior wall of the oropharynx so that only a mucosal strip of approx. 3 to 4 mm remains in the area of the posterior wall of the oropharynx. Retraction of the soft palate. It can now be seen that the tumor is clearly infiltrating cranially via the posterior surface of the posterior palatal arch. Therefore extension of the resection. Resection down to the hard palate. Cut off the posterior edge of the maxilla down to the choanae and the posterior edge of the septum. For reasons of overview, the main tumor is removed first and isolated to the cranial part. Form a post-resection by removing the posterior edge of the maxilla as described above. Resection up to the tubal bulges. The ostia remain intact. Complete covering here in the nasopharyngeal region in the area of the mucosal settling margins. Otherwise, take marginal samples from the specimen. The specimen is thread-marked for definitive histology. Marking of the separated tumor portion, otherwise macroscopic in sano resection on the specimen. Complete covering of the tumor with margin samples as far as possible. In this case, frozen section diagnostics show an in sano resection for the invasive carcinoma. Only in the area of the margin in the area of the left lateral tonsillar lobe is there a CIS and in the area of the posterior pharyngeal wall a suspicion of CIS as well as moderate dysplasia. A resection was performed in the area lateral to the left tonsil and covered with a new marginal specimen, which was found to be tumor-free. Due to the circumscribed pharyngeal remnant and the proximity of the tumor, the decision was made to completely resect the posterior pharyngeal wall and preserve the prevertebral fascia. After confirmation of the N0 situation, the neck is first dissected on the right side. To do this, make an incision on the anterior edge of the sternocleidomastoid muscle. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digatric muscle. Exposure and preservation of the external jugular vein, internal jugular vein, facial vein, superior thyroid artery, cervical artery, hypoglossal nerve. Exposure of the common carotid artery and vagus nerve. Clearing of the accessorius triangle with careful protection of the nerve and completion of level V with careful protection of the cervical plexus branches. Macroscopically conspicuous nodes in level II, otherwise macroscopically inconspicuous site. If the wound is dry, the tracheotomy is then performed. The skin incision is made horizontally below the cricoid cartilage. Cut through skin and subcutaneous tissue. Exposure and transection of the infrahyoid muscles. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Dissection of the thyroid isthmus. Due to the height of the larynx, insertion between the 1st and 2nd tracheal ring. Formation of a visor tracheotomy and incision of the skin in the typical manner. Subsequent intubation onto a tube. At the end of the procedure, reintubation onto a size 8 low-cuff cannula, which is suture-fixed. The anterolateral thigh graft is now lifted from the right after doppler sonographic identification of the main perforator and a secondary perforator. The graft, measuring 17 x 8 cm in total, is marked. Medial incision. Cut through skin and subcutaneous tissue. Cutting through the fascia lata. Exposing and securing the rectus femoris muscle. Subfascial dissection. Identification of the pedicle vessel. Subsequent identification of the main perforator. Dissection of the perforator down to the pedicle vessel with musculocutaneous perforator course. In the area of the perforator junction, leave the fascia lata on the graft, otherwise leave in situ. Complete resection and release. Isolation on the perforator and the pedicle vessel. Subsequent removal of the excellent vital graft after supplying the feeding and draining vessels. Careful monitoring of the thigh area and, if the wound is dry, insertion of a 10 Redon drain and careful multi-layer wound closure with adaptation of the skin edges. The combined transcervical and transoral insertion of the graft is now performed. The conditions here are considerably more difficult due to the extensive defect. Finally, however, good reconstruction. In the area of the posterior pharyngeal wall, the graft is sutured to the prevertebral fascia and a narrow exposed margin is left here. Good reconstruction of the soft palate and the nasopharyngeal section. Intact conditions on all sides. Stalk positioning to the right cervical side, after previous creation of a tunnel measuring approximately 3 transverse fingers. The superior thyroid artery is then dissected and conditioned. Perform the arterial anastomosis with 8.0 Ethilon. This works well. Immediate venous return via both draining veins. First condition the facial vein. Perform the anastomosis with the coupler system. If there is still clear venous return via the second vein, the second vein is anastomosed to the external jugular vein, also using the Coupler system. Subsequently, a regular pedicle position and a positive spreading phenomenon and vital graft enorally, so that a 10 Redon drain is then inserted and the wound is carefully closed in two layers. Neck dissection on the left side. The skin incision here corresponds to the opposite side. Cut through skin and subcutaneous tissue. Exposure of the sternocleidomastoid muscle, omohyoid muscle. Release of the submandibular gland. Exposure of the digastric muscle. Dissection of the internal jugular vein, facial vein, superior thyroid artery, cervical artery, hypoglossal nerve. Exposure and clearing of the accessorius triangle with careful protection of the nerve. Exposure of the internal jugular vein, vagus nerve and common carotid nerve and evacuation of level V with careful protection of the cervical plexus branches. If the wound is dry, insertion of a 10-gauge Redon drain. Subsequent careful two-layer wound closure and completion of the procedure with a vital graft and no indication of complications. Conclusion: Extensive growing cT3 cN2c oropharyngeal carcinoma on both sides with discrete right emphasis. Due to the extensive defect, initial feeding via the existing PEG tube for at least 8 to 9 days. If the graft heals properly, a gradual increase in nutrition can then take place; if necessary, a prolonged recovery of swallowing function can be expected due to the extent of the defect. Presentation at our interdisciplinary tumor conference to determine the extent of adjuvant therapy. \ No newline at end of file diff --git a/535/InvasionFront_CD3_block19_x5_y2_patient535_0.json b/535/InvasionFront_CD3_block19_x5_y2_patient535_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be2a4ed951c848c60a8456c67f34cb2fae6db907 --- /dev/null +++ b/535/InvasionFront_CD3_block19_x5_y2_patient535_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17728.1, + "Centroid Y µm": 7783.4, + "Num Detections": 18077, + "Num Negative": 17974, + "Num Positive": 103, + "Positive %": 0.5698, + "Num Positive per mm^2": 47.05 + } +} \ No newline at end of file diff --git a/535/InvasionFront_CD3_block19_x6_y2_patient535_1.json b/535/InvasionFront_CD3_block19_x6_y2_patient535_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0c3192b7a9d2ecde3d67e0b2fcf2380a391b6c2 --- /dev/null +++ b/535/InvasionFront_CD3_block19_x6_y2_patient535_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20357.3, + "Centroid Y µm": 8028.9, + "Num Detections": 21629, + "Num Negative": 21210, + "Num Positive": 419, + "Positive %": 1.937, + "Num Positive per mm^2": 176.54 + } +} \ No newline at end of file diff --git a/535/InvasionFront_CD8_block19_x5_y2_patient535_0.json b/535/InvasionFront_CD8_block19_x5_y2_patient535_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8da5b75e9dddc6c30d6faea6e6e2d4e36b116dbc --- /dev/null +++ b/535/InvasionFront_CD8_block19_x5_y2_patient535_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 15167.0, + "Num Detections": 22637, + "Num Negative": 22151, + "Num Positive": 486, + "Positive %": 2.147, + "Num Positive per mm^2": 198.61 + } +} \ No newline at end of file diff --git a/535/InvasionFront_CD8_block19_x6_y2_patient535_1.json b/535/InvasionFront_CD8_block19_x6_y2_patient535_1.json new file mode 100644 index 0000000000000000000000000000000000000000..327479469c1bdb43854fe8b1d5565c93312e3fbf --- /dev/null +++ b/535/InvasionFront_CD8_block19_x6_y2_patient535_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19589.6, + "Centroid Y µm": 15167.0, + "Num Detections": 20348, + "Num Negative": 19644, + "Num Positive": 704, + "Positive %": 3.46, + "Num Positive per mm^2": 321.8 + } +} \ No newline at end of file diff --git a/535/TumorCenter_CD3_block19_x5_y2_patient535_0.json b/535/TumorCenter_CD3_block19_x5_y2_patient535_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a2d2bf16bb58f2e5581c7d1df00d2445fd24a4ea --- /dev/null +++ b/535/TumorCenter_CD3_block19_x5_y2_patient535_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15466.8, + "Centroid Y µm": 5497.1, + "Num Detections": 20654, + "Num Negative": 19487, + "Num Positive": 1167, + "Positive %": 5.65, + "Num Positive per mm^2": 509.11 + } +} \ No newline at end of file diff --git a/535/TumorCenter_CD3_block19_x6_y2_patient535_1.json b/535/TumorCenter_CD3_block19_x6_y2_patient535_1.json new file mode 100644 index 0000000000000000000000000000000000000000..62005343886e238ec39042e4f0685ac64a2162aa --- /dev/null +++ b/535/TumorCenter_CD3_block19_x6_y2_patient535_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17940.5, + "Centroid Y µm": 4997.4, + "Num Detections": 17562, + "Num Negative": 16947, + "Num Positive": 615, + "Positive %": 3.502, + "Num Positive per mm^2": 277.43 + } +} \ No newline at end of file diff --git a/535/TumorCenter_CD8_block19_x5_y2_patient535_0.json b/535/TumorCenter_CD8_block19_x5_y2_patient535_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c9af69fe982cc3019f495c11ff1aead6c7437167 --- /dev/null +++ b/535/TumorCenter_CD8_block19_x5_y2_patient535_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18563.5, + "Centroid Y µm": 15708.3, + "Num Detections": 19460, + "Num Negative": 19061, + "Num Positive": 399, + "Positive %": 2.05, + "Num Positive per mm^2": 176.73 + } +} \ No newline at end of file diff --git a/535/TumorCenter_CD8_block19_x6_y2_patient535_1.json b/535/TumorCenter_CD8_block19_x6_y2_patient535_1.json new file mode 100644 index 0000000000000000000000000000000000000000..502070f51602c5fe9109e2b9e4de6d1c5d0b9f0d --- /dev/null +++ b/535/TumorCenter_CD8_block19_x6_y2_patient535_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21074.3, + "Centroid Y µm": 15629.3, + "Num Detections": 18812, + "Num Negative": 18671, + "Num Positive": 141, + "Positive %": 0.7495, + "Num Positive per mm^2": 60.5 + } +} \ No newline at end of file diff --git a/535/history_text.txt b/535/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9c63b95d6a6c620e00eef72148765417149ef80f --- /dev/null +++ b/535/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma G2 in the left vocal fold area. The above-mentioned operation was therefore indicated using laser technology. \ No newline at end of file diff --git a/535/icd_codes.txt b/535/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..31f58876b28caf6583e662fc242ecb509734f250 --- /dev/null +++ b/535/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 L] \ No newline at end of file diff --git a/535/ops_codes.txt b/535/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..55e55b5f313876471cb9e5891f1e99fce416fdaa --- /dev/null +++ b/535/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] CO2-Lasertechnik[5-985.1 ] Sonstige partielle Laryngektomie[5-302.x ] \ No newline at end of file diff --git a/535/patient_clinical_data.json b/535/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6e2341c8e96ff7cc87f8ba25be20efee94786200 --- /dev/null +++ b/535/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 50, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 6, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/535/patient_pathological_data.json b/535/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e52975e48ab6a142e82a1c9131f88e16ef6e652a --- /dev/null +++ b/535/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "535", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.5 +} \ No newline at end of file diff --git a/535/surgery_description.txt b/535/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f71ffb574d9cb199582c43a70d74f2b3e887fe5c --- /dev/null +++ b/535/surgery_description.txt @@ -0,0 +1 @@ +Laserresektion diff --git a/535/surgery_report.txt b/535/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b995be4efbe30e842a10752256f49eb1393bdb1d --- /dev/null +++ b/535/surgery_report.txt @@ -0,0 +1 @@ +First of all, after induction of anesthesia, inspection of the findings with 30° endoscopy. The tumor extends from the arytenoid region to the anterior commissure. This is not exceeded and just barely not reached. Tumor grows broadly laterally in the direction of the laryngeal ventricle. Subsequent adjustment of the tumor with the support autoscopy and small bore tube size C. Removal of the tumor in the area of the anterior commissure, whereby this is just exceeded to the right in order to achieve an R0 resection. Lasering anteriorly up to the cartilage and pushing off the tumor. Right anterior margin from subglottic to supraglottic. Subsequent adjustment of the tumor dorsally. Laser the tumor with a safety distance of 3 to 4 mm, as already done in the front. The anterior and middle parts of the arytenoid cartilage are removed. Ablate the tumor from dorsal to ventral. Cartilage is reached laterally. The tumor is ablated just above the perichondrium. Particular attention is paid to a safe distance in the arytenoid cartilage area. Conus elasticus is also grasped caudally. First take a marginal sample dorsally from the area between the arytenoid cartilage and the cricoid cartilage, here extensive soft tissue is taken as a sample. Also mucosal margin sample in the arytenoid region. Further laser removal of the specimen along the perichondrium, taking the paraglottic musculature as far forward as possible. Removal of the specimen. This is thread-marked laterally, dorsally and caudally and sent for frozen section. The removed marginal samples are also sent to the frozen section, all of which are free. The specimen is also free, but just reaches the border laterally in the caudal direction. Therefore, the perichondrium is now removed from the cartilage and a soft tissue layer is removed caudally between the cricoid cartilage and the thyroid cartilage as a lateral-caudal margin specimen. The mucosa is also removed caudally in the area of the conus elasticus. This marginal sample is sent for final diagnosis. Subsequent careful hemostasis. The procedure is completed when the site is absolutely free of bleeding. Overall T1 to 2 glottic carcinoma with coverage of the entire vocal fold on the left and ingrowth in the direction of the laryngeal ventricle. Therefore, inclusion of cranial parts of the pocket fold and soft tissue up to the thyroid cartilage. Overall preparation R0 removed. A resection was carried out in areas where the margins were barely reached. Further procedure depending on the final histology. In any case, plan a follow-up endoscopy in 8 to 12 weeks. \ No newline at end of file diff --git a/536/InvasionFront_CD3_block6_x3_y4_patient536_0.json b/536/InvasionFront_CD3_block6_x3_y4_patient536_0.json new file mode 100644 index 0000000000000000000000000000000000000000..826a8640835c5f317e1b9065f1f8da4bba3deb1f --- /dev/null +++ b/536/InvasionFront_CD3_block6_x3_y4_patient536_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12593.3, + "Centroid Y µm": 10494.4, + "Num Detections": 18323, + "Num Negative": 17642, + "Num Positive": 681, + "Positive %": 3.717, + "Num Positive per mm^2": 357.52 + } +} \ No newline at end of file diff --git a/536/InvasionFront_CD3_block6_x4_y4_patient536_1.json b/536/InvasionFront_CD3_block6_x4_y4_patient536_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3843054dd7c646fa33b8474c3b42d9948ff79442 --- /dev/null +++ b/536/InvasionFront_CD3_block6_x4_y4_patient536_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14967.1, + "Centroid Y µm": 10719.3, + "Num Detections": 18994, + "Num Negative": 18451, + "Num Positive": 543, + "Positive %": 2.859, + "Num Positive per mm^2": 281.78 + } +} \ No newline at end of file diff --git a/536/InvasionFront_CD8_block6_x3_y2_patient536_0.json b/536/InvasionFront_CD8_block6_x3_y2_patient536_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cffa9ca476ddbe1a7d2d9d80da63b5de5eae3be8 --- /dev/null +++ b/536/InvasionFront_CD8_block6_x3_y2_patient536_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12743.3, + "Centroid Y µm": 4772.5, + "Num Detections": 26481, + "Num Negative": 26120, + "Num Positive": 361, + "Positive %": 1.363, + "Num Positive per mm^2": 130.43 + } +} \ No newline at end of file diff --git a/536/InvasionFront_CD8_block6_x4_y2_patient536_1.json b/536/InvasionFront_CD8_block6_x4_y2_patient536_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a04caa17208eed73c39c290cd4c8cd72066c2788 --- /dev/null +++ b/536/InvasionFront_CD8_block6_x4_y2_patient536_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15516.8, + "Centroid Y µm": 4897.4, + "Num Detections": 25244, + "Num Negative": 24549, + "Num Positive": 695, + "Positive %": 2.753, + "Num Positive per mm^2": 258.71 + } +} \ No newline at end of file diff --git a/536/TumorCenter_CD3_block6_x3_y2_patient536_0.json b/536/TumorCenter_CD3_block6_x3_y2_patient536_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4eea4734e99b4888f1624880691bc9e20e6e7ced --- /dev/null +++ b/536/TumorCenter_CD3_block6_x3_y2_patient536_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11094.1, + "Centroid Y µm": 4997.4, + "Num Detections": 31984, + "Num Negative": 30772, + "Num Positive": 1212, + "Positive %": 3.789, + "Num Positive per mm^2": 419.18 + } +} \ No newline at end of file diff --git a/536/TumorCenter_CD3_block6_x4_y2_patient536_1.json b/536/TumorCenter_CD3_block6_x4_y2_patient536_1.json new file mode 100644 index 0000000000000000000000000000000000000000..18b999b6c687a98468d1bd3021b646dfbcf9c410 --- /dev/null +++ b/536/TumorCenter_CD3_block6_x4_y2_patient536_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 4897.4, + "Num Detections": 30380, + "Num Negative": 29216, + "Num Positive": 1164, + "Positive %": 3.831, + "Num Positive per mm^2": 399.1 + } +} \ No newline at end of file diff --git a/536/TumorCenter_CD8_block6_x3_y2_patient536_0.json b/536/TumorCenter_CD8_block6_x3_y2_patient536_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9c329e0532285ca7c09dbd4d1c8697393afaf4c7 --- /dev/null +++ b/536/TumorCenter_CD8_block6_x3_y2_patient536_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 5447.1, + "Num Detections": 32682, + "Num Negative": 32574, + "Num Positive": 108, + "Positive %": 0.3305, + "Num Positive per mm^2": 37.59 + } +} \ No newline at end of file diff --git a/536/TumorCenter_CD8_block6_x4_y2_patient536_1.json b/536/TumorCenter_CD8_block6_x4_y2_patient536_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7fd1b6451954cacb89aebc43ac7320043b66853e --- /dev/null +++ b/536/TumorCenter_CD8_block6_x4_y2_patient536_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 5422.1, + "Num Detections": 31478, + "Num Negative": 31293, + "Num Positive": 185, + "Positive %": 0.5877, + "Num Positive per mm^2": 64.01 + } +} \ No newline at end of file diff --git a/536/history_text.txt b/536/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fd067f06a07688c0471b194c37e2a016ef454dfd --- /dev/null +++ b/536/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed cT2 cN1 oropharyngeal carcinoma on the right side. In the area of the right oropharyngeal side wall with spread to the base of the tongue and tumor infiltration up to the anterior palatal arch. The B-image sonographic examination shows a lymph node metastasis in region II on the right side with relatively close contact to the tumor. Based on the findings, the indication for enoral tumor resection and bilateral neck dissection was concluded. The patient was informed preoperatively and had sufficient time to ask questions. \ No newline at end of file diff --git a/536/icd_codes.txt b/536/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/536/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/536/ops_codes.txt b/536/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3ea779cf20f59e10ab6bbfd777b75b5f76856dcf --- /dev/null +++ b/536/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Anwendung eines komplexen OP-Roboters (Zusatzkode)[5-987.0 ] Sonstige partielle Glossektomie sonstige[5-251.xx ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/536/patient_clinical_data.json b/536/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c2e67a186a5bc1ba47790aa7596386fea5bf070b --- /dev/null +++ b/536/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 59, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 8, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/536/patient_pathological_data.json b/536/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b1ff5427849e03a20d5858846df7486295161d38 --- /dev/null +++ b/536/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "536", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/536/surgery_description.txt b/536/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..091a2d511c9f3c30fce0ab9092edd666ce4a9d9a --- /dev/null +++ b/536/surgery_description.txt @@ -0,0 +1 @@ +Tonsillektomie (TORS) diff --git a/536/surgery_report.txt b/536/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0bea31d5d9d1abdfee7864b1241d879305b0bdba --- /dev/null +++ b/536/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the central OR (room 13). Introductory consultation with the anesthesia colleagues and induction of intubation anesthesia by the colleagues. Intubation with an 8 mm Woodbridge tube. Start of the operation using flexible gastroesophagoscopy by . Careful advancement into the stomach and air insufflation. Attempt to perform a diaphanoscopy, which is unsuccessful. Now aspiration of air and careful reflection back through the esophagus during air insufflation. Conclusion: Due to the negative diaphanoscopy, a PEG is dispensed with. The tumor is now positioned with the Kleinsasser tube size C. An ulcerative mass is seen in the area of the right oropharyngeal side wall, which merges into the right-sided base of the tongue. This mass extends cranially to the anterior palatal arch. The other mucosal areas are not suspicious. Now insertion of the Tors mouth retractor. Exposure of the tumor and docking of the robotic arms in the usual manner. The 0° optics are used. Now start the tumor incision after consulting the resection margins with . The tumor is removed at the cranial margin with sufficient safety distance (over 1 cm) in the area of the anterior palatal arch. Careful medialization of the tumour specimen and dissection using electrocoagulation in the parapharyngeal musculature. Constant attention is paid to maintaining a sufficient safety distance from the tumor. The parapharyngeal fat is visible laterally. Now also resection in the area of the base of the tongue with sufficient safety distance. The tumor resectate can now also be detached from the posterior wall of the oropharynx. Suture marking of the specimen and sending in for frozen section diagnostics as well as generous resection in the area of the anterior palatal arch from the parauvular to the alveolar ridge. Both specimens are thread- and needle-marked on a cork plate for histologic frozen section examination. After consultation with the pathologist, the main specimen showed an R0 resection in the cranial direction (parauvularly only just in the healthy area), and the resected specimen showed no further tumor cells. Conclusion: An R0 situation can now definitely be assumed with a wide safety margin on all sides. Subtle hemostasis is performed using bipolar coagulation forceps. As there is no major bleeding, a protective tracheostomy is not performed. The operation was completed without complications. Summary: Enoral robot-assisted tumor resection of a T2 N1 oropharyngeal carcinoma on the right side with R0 resection confirmed by frozen section diagnostics. Due to a negative diaphanoscopy, a PEG had to be omitted. \ No newline at end of file diff --git a/537/InvasionFront_CD3_block12_x1_y4_patient537_0.json b/537/InvasionFront_CD3_block12_x1_y4_patient537_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f077673c5d0db496d9990315c658343c2eb1b5f --- /dev/null +++ b/537/InvasionFront_CD3_block12_x1_y4_patient537_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4397.7, + "Centroid Y µm": 14092.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/537/InvasionFront_CD3_block12_x2_y4_patient537_1.json b/537/InvasionFront_CD3_block12_x2_y4_patient537_1.json new file mode 100644 index 0000000000000000000000000000000000000000..13e2a4dc33f328c846efc255700499efa29006d4 --- /dev/null +++ b/537/InvasionFront_CD3_block12_x2_y4_patient537_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7039.9, + "Centroid Y µm": 14450.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/537/InvasionFront_CD8_block12_x1_y4_patient537_0.json b/537/InvasionFront_CD8_block12_x1_y4_patient537_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6c5bbfdbd8524bbcadbd579ba4d12517fc21dcb9 --- /dev/null +++ b/537/InvasionFront_CD8_block12_x1_y4_patient537_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4247.8, + "Centroid Y µm": 14159.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/537/InvasionFront_CD8_block12_x2_y4_patient537_1.json b/537/InvasionFront_CD8_block12_x2_y4_patient537_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e40dc22daf3000ca145b03ea36a375320be5749 --- /dev/null +++ b/537/InvasionFront_CD8_block12_x2_y4_patient537_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6959.7, + "Centroid Y µm": 14066.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/537/TumorCenter_CD3_block12_x1_y4_patient537_0.json b/537/TumorCenter_CD3_block12_x1_y4_patient537_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aca5cf513e36abc129229f415f4d3d1d98ab096c --- /dev/null +++ b/537/TumorCenter_CD3_block12_x1_y4_patient537_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 9744.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/537/TumorCenter_CD3_block12_x2_y4_patient537_1.json b/537/TumorCenter_CD3_block12_x2_y4_patient537_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ed0d8d4a8a4aaf9330a0c4da206da71a72cfd231 --- /dev/null +++ b/537/TumorCenter_CD3_block12_x2_y4_patient537_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 9769.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/537/TumorCenter_CD8_block12_x1_y4_patient537_0.json b/537/TumorCenter_CD8_block12_x1_y4_patient537_0.json new file mode 100644 index 0000000000000000000000000000000000000000..278b6ae86cdf4179f9753db4d6a7e2d5f0a50bd2 --- /dev/null +++ b/537/TumorCenter_CD8_block12_x1_y4_patient537_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7094.5, + "Centroid Y µm": 18872.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/537/TumorCenter_CD8_block12_x2_y4_patient537_1.json b/537/TumorCenter_CD8_block12_x2_y4_patient537_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9cb9ee7ea892858c0fa0591e880ea79ff0fdb25e --- /dev/null +++ b/537/TumorCenter_CD8_block12_x2_y4_patient537_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9512.0, + "Centroid Y µm": 18961.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/537/history_text.txt b/537/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..eb559d21127c3e35ed0f6a869189d51edc1517c1 --- /dev/null +++ b/537/history_text.txt @@ -0,0 +1 @@ +The patient has an externally confirmed tonsillar carcinoma on the right side. In the findings of the CT scan, this does not appear to respect the boundaries of the tonsil and infiltrates the palate towards the uvula. In addition, there are conspicuous lymph nodes on both cervical sides. \ No newline at end of file diff --git a/537/icd_codes.txt b/537/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5e83105e7bf11f6ca52dbd4665319746d4a9a92e --- /dev/null +++ b/537/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/537/ops_codes.txt b/537/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1849cc57675a5bb6d5cf96e4fd6888026da9bff3 --- /dev/null +++ b/537/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Pharyngoskopie direkt[1-611.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Diagnostische indirekte Pharyngoskopie onA[1-611.1 ] Diagnostische Laryngoskopie direkt[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument[1-620.1 ] Diagnostische Ösophagogastroskopie[1-631 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Transorale Tumortonsillektomie[5-281.2 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] \ No newline at end of file diff --git a/537/patient_clinical_data.json b/537/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0a2c3c0ce9c2ecfb4bad60c22b2cee0203734f44 --- /dev/null +++ b/537/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": null, + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin + etoposid", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/537/patient_pathological_data.json b/537/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..79441fa46a8dd5e94e73311b5a1a8487029d10d9 --- /dev/null +++ b/537/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "537", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/537/surgery_description.txt b/537/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b8375466485f7776cfb8148ac4d433ace481e8f --- /dev/null +++ b/537/surgery_description.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie & Neck Dissection diff --git a/537/surgery_report.txt b/537/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2cdd05226b332d76e04d6d8c95ea9f9a722473ed --- /dev/null +++ b/537/surgery_report.txt @@ -0,0 +1 @@ +First, panendoscopy and confirmation of the suspected diagnosis of cT2 tonsillar carcinoma. This shows an exophytic mass of the tonsil in the area of the upper tonsil pole. This spreads from here to the soft palate and reaches the base of the uvula on the right side. The lower tonsil pole appears tumor-free. However, there is a fish bone in the tonsil, which is removed. When looking forward with the small bore tube in the direction of the hypopharynx and larynx, the mucosal conditions are otherwise normal and inconspicuous. The hypopharynx in the sense of the piriform sinus can be fully unfolded on both sides and the postcricoid region as well as the esophageal entrance plane are inconspicuous. The endolaryngeal mucosa is also unremarkable. Rigid tracheobronchoscopy had already been performed during intubation. Here too, the subglottic and tracheal mucosa up to the main bronchi was unremarkable. After repositioning the patient, the flexible esophagoscope was inserted and the esophagus was visualized. This reveals a regular fold relief. With positive diaphanoscopy and a positive tent phenomenon, the PEG tube can then be inserted without any problems using the thread pull-through method. On reflection, the esophageal mucosa was carefully inspected again, which also proved to be non-irritating and unremarkable. This confirms the suspected diagnosis of an externally confirmed cT2 tonsil carcinoma, which is why the patient is now transferred for tumor tonsillectomy and neck dissection on both sides: First, skin incision along the soft palate and dissection of the anterior palatal arch caudally. At the lower pole, first expose the tonsil capsule. There is no evidence of tumor growth beyond the capsule. Therefore, expose the caudal pole vessels, which are then carefully coagulated and cut. The tonsil is then removed at the lower pole and dissected cranially. Then dissect into the soft tissue of the oropharyngeal side wall and the muscles of the palate. Maintain a sufficient safety distance of about 8 mm from the exophytic change in the upper pole of the tonsil. The resection is then performed up to the middle of the base of the uvula, which is then also resected. However, the tip of the uvula remains intact during the resection. After further posterior dissection, the tonsil can then be completely removed together with the exophytic change. Suture marking of the preparation is now carried out outside the site in the area of the margin of the abscess at the base of the uvula and in the area of the abscess margins in the area of the wound base at the caudal and cranial lateral tonsil pole. Circularly, the mucosa of the tonsil is also macroscopically inconspicuous on the preparation. The entire preparation is then sent for frozen section diagnostics. Intraoperatively, all suture markings are found to be tumor-free and the R0 resection is confirmed on the specimen. After subtle hemostasis, the wound surface of the uvula is fixed to the anterior soft palate in the area of the margin on the right side with several sutures. Then, after checking the bleeding again, removal of the mouth retractor and repositioning of the patient for neck dissection: After injection of local anesthetic with adrenaline in the area of the anterior edge of the sternocleidomastoid muscle on both sides of the neck, first abjode and position the patient. Then start the neck dissection on the right side with an incision along the anterior border of the sternocleidomastoid muscle. After cutting through the platysma, dissection in layers in depth. Exposure of the cervical vascular sheath. Exposure of the omohyoid muscle and the digaster muscle. Finding and protecting the accessorius nerve. A large lymph node conglomerate can be seen here in the area of the venous angle. Therefore, very careful dissection along the cervical vascular sheath and sharp dissection of the lymph node conglomerate from the cervical vascular sheath. All structures of the cervical vascular sheath are spared. Then develop the entire lateral neck preparation from the accessorius triangle to the level of the omohyoid muscle. Then evacuate the hypoglossal triangle while sparing the branches of the external carotid artery and internal jugular artery as well as the hypoglossal nerve. The caudal medial neck preparation is then also completely dissected, sparing the vascular branches. The entire neck preparation of the right side is then sent for histological examination. Subsequent subtle hemostasis and insertion of the Redon drainage. Then two-layer wound closure and repositioning of the patient for neck dissection on the left side: here too, skin incision along the anterior edge of the sternocleidomastoid muscle. Dissection in depth in layers until the cervical sheath is exposed. Then dissect and expose the omohyoid muscle and digaster muscle. Locate and protect the accessorius nerve. Then dissection of the entire lateral neck preparation from the accessorius triangle to the level of the omohyoid muscle. Then clearing of the hypoglossal triangle. Here too, a large lymph node conglomerate can be seen in the area of the venous angle, which must be dissected sharply away from the cervical vascular sheath during the dissection of the hypoglossal triangle. The entire dissection is carried out while protecting the outlets of the internal jugular vein and external carotid artery. Finally, dissection of the caudal medial preparation, also with protection of the vascular outlets. After renewed subtle hemostasis, a Redon drain was also inserted here and then the wound was closed in two layers. The overall result is a selective neck dissection on both sides of levels II to V. At the end of the operation, the wound is checked again enorally. If the wound is dry, the procedure is then completed. Further procedure depending on the histopathological findings. \ No newline at end of file diff --git a/538/InvasionFront_CD3_block18_x3_y6_patient538_0.json b/538/InvasionFront_CD3_block18_x3_y6_patient538_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9c78d9ef5c0818c1d47d5e9d28f77703353ddd75 --- /dev/null +++ b/538/InvasionFront_CD3_block18_x3_y6_patient538_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11294.0, + "Centroid Y µm": 19839.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/538/InvasionFront_CD3_block18_x4_y6_patient538_1.json b/538/InvasionFront_CD3_block18_x4_y6_patient538_1.json new file mode 100644 index 0000000000000000000000000000000000000000..973efecc502ce850dae2a346890bad0d2ba0a4a6 --- /dev/null +++ b/538/InvasionFront_CD3_block18_x4_y6_patient538_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 19889.5, + "Num Detections": 15269, + "Num Negative": 12282, + "Num Positive": 2987, + "Positive %": 19.56, + "Num Positive per mm^2": 1540.3 + } +} \ No newline at end of file diff --git a/538/InvasionFront_CD8_block18_x3_y6_patient538_0.json b/538/InvasionFront_CD8_block18_x3_y6_patient538_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9010a1b5277cfe5b1280ad2515343887f4f5b63a --- /dev/null +++ b/538/InvasionFront_CD8_block18_x3_y6_patient538_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 22912.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/538/InvasionFront_CD8_block18_x4_y6_patient538_1.json b/538/InvasionFront_CD8_block18_x4_y6_patient538_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5b214a503c0e173453dae9a5f274eecb3447f613 --- /dev/null +++ b/538/InvasionFront_CD8_block18_x4_y6_patient538_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 22787.9, + "Num Detections": 14477, + "Num Negative": 12009, + "Num Positive": 2468, + "Positive %": 17.05, + "Num Positive per mm^2": 1327.5 + } +} \ No newline at end of file diff --git a/538/TumorCenter_CD3_block18_x3_y6_patient538_0.json b/538/TumorCenter_CD3_block18_x3_y6_patient538_0.json new file mode 100644 index 0000000000000000000000000000000000000000..227cb9f72af874fa3e8f863b7c8b2fc0f99f946e --- /dev/null +++ b/538/TumorCenter_CD3_block18_x3_y6_patient538_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10802.5, + "Centroid Y µm": 14529.8, + "Num Detections": 14503, + "Num Negative": 13518, + "Num Positive": 985, + "Positive %": 6.792, + "Num Positive per mm^2": 523.42 + } +} \ No newline at end of file diff --git a/538/TumorCenter_CD3_block18_x4_y6_patient538_1.json b/538/TumorCenter_CD3_block18_x4_y6_patient538_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e816bb1963f81d961f1c7a8184d8a8d2f905c167 --- /dev/null +++ b/538/TumorCenter_CD3_block18_x4_y6_patient538_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13278.4, + "Centroid Y µm": 14592.3, + "Num Detections": 13948, + "Num Negative": 12900, + "Num Positive": 1048, + "Positive %": 7.514, + "Num Positive per mm^2": 578.63 + } +} \ No newline at end of file diff --git a/538/TumorCenter_CD8_block18_x3_y6_patient538_0.json b/538/TumorCenter_CD8_block18_x3_y6_patient538_0.json new file mode 100644 index 0000000000000000000000000000000000000000..905fa9b04d078b4901cce5c58ebaf258e581d670 --- /dev/null +++ b/538/TumorCenter_CD8_block18_x3_y6_patient538_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10719.3, + "Centroid Y µm": 15316.9, + "Num Detections": 14814, + "Num Negative": 13889, + "Num Positive": 925, + "Positive %": 6.244, + "Num Positive per mm^2": 502.83 + } +} \ No newline at end of file diff --git a/538/TumorCenter_CD8_block18_x4_y6_patient538_1.json b/538/TumorCenter_CD8_block18_x4_y6_patient538_1.json new file mode 100644 index 0000000000000000000000000000000000000000..34a3332d1fcbb806d5b89898b3dc630894375296 --- /dev/null +++ b/538/TumorCenter_CD8_block18_x4_y6_patient538_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 15366.9, + "Num Detections": 13582, + "Num Negative": 12743, + "Num Positive": 839, + "Positive %": 6.177, + "Num Positive per mm^2": 449.74 + } +} \ No newline at end of file diff --git a/538/history_text.txt b/538/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6fd824e821db53ba021825dc6c9b07783f1c0b8b --- /dev/null +++ b/538/history_text.txt @@ -0,0 +1 @@ +Patient with a cT4a cN2c cM0 G2 squamous cell carcinoma in the transglottic area and indication for the above-mentioned measures after patient presentation in the tumor board. \ No newline at end of file diff --git a/538/icd_codes.txt b/538/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..081f97f0ed4dfcd2bd98ecb0f74ca414d9fe43c0 --- /dev/null +++ b/538/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] \ No newline at end of file diff --git a/538/ops_codes.txt b/538/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..03f63c8cadc7709f6c80f85193768d172ff7f2a7 --- /dev/null +++ b/538/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Erweiterungsplastik Tracheostoma[5-316.3 ] \ No newline at end of file diff --git a/538/patient_clinical_data.json b/538/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f04f418ac782528e5e1ed8c7d25d75b1e1a360c4 --- /dev/null +++ b/538/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/538/patient_pathological_data.json b/538/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d41c15c9849fe93e49206926eb672d8aa1b10367 --- /dev/null +++ b/538/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "538", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 9.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/538/surgery_description.txt b/538/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d490761acf39c7c6aee62b5c10c14a2440f3bf68 --- /dev/null +++ b/538/surgery_description.txt @@ -0,0 +1 @@ +Laryngektomie, Neck diss. bds., Tracheostomarevision diff --git a/538/surgery_report.txt b/538/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b8c4b41ab59a3f01209551095b681974804d8f0 --- /dev/null +++ b/538/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia, endotracheal intubation via the existing tracheostoma by the anesthesia colleagues and positioning of the patient by the surgeon. Laryngoscopy was first performed using a Kleinsasser C-tube. This revealed a tumor that completely obstructed the entire laryngeal lumen from the median area of the aryepiglottic folds on both sides to the subglottic region. In addition, one has the impression that the tracheostoma has been inserted close to the tumor. Skin spray disinfection, application of local anesthesia cervically on both sides and around the existing tracheostoma. Skin ablation and sterile draping. Creation of a skin incision, transection of the subcutaneous tissue and the platysma and formation of a subplatysmal apron flap up to the level of the hyoid bone, which is then fixed in place using bridle sutures. The anterior edge of the sternocleidomastoid muscle is then exposed on the right side. Exposure of the anterior jugular vein and the right external jugular vein, which are ligated and cut. Dissection along the sternocleidomastoid muscle in depth. The branches of the cervical plexus are exposed in depth and spared. Now also expose the omohyoid muscle and dissect along the muscle to the hyoid bone. Identification of the N. accessorius and free preparation of the nerve from the neck preparation. At the junction with the internal jugular vein, the digaster venter posterior muscle is exposed and completely freed from the neck preparation. Expose the submandibular gland and dissect the digastric muscle up to the hyoid bone. Now focus on the internal jugular vein just above the omohyoid muscle. Dissection shows that 2 lymph node metastases measuring approx. 1 cm are firmly attached to the vein wall. On closer examination, the high-grade evidence of infiltration of the vascular wall is revealed. In consultation with , it was decided to include the internal jugular vein in the neck preparation. For this purpose, expose the vein cranially just below the digastric muscle and caudally just cranial to the omohyoid muscle. Expose the common carotid artery, the carotid bifurcation and the vagus nerve along the entire course of the dissected vein. Now first remove the vein caudally and place 2 vascular ligatures on the vascular stump. The same procedure is also carried out cranially, sparing the hypoglossal nerve and the accessory nerve. Both nerves can be exposed and spared. The entire neck preparation is then removed from cranial to caudal, including the vein and constant bleeding control using bipolar coagulation forceps. The preparation is carried out with constant consideration of the nerves of the cervical plexus and the phrenic nerve on the scalene muscle. Removal of the neck preparation without complications. Hemostasis dorlt by means of bipolar coagulation and subsequent repositioning of the patient on the left side to perform the neck dissection. Dissection along the anterior border of the sternocleidomastoid muscle. Exposure of the accessorius nerve, digaster muscle and omohyoid muscle. Exposure of the cervical vascular sheath. Successive evacuation of the posterior and anterior neck preparation while sparing the above-mentioned structures and the plexus branches. In region IV, several suspicious masses were found on the left side, which were then removed with the specimen. Hemostasis there by means of bipolar coagulation. Subsequently, the skin of the already existing tracheostoma was cut circularly. Additional removal of the prelaryngeal fatty tissue subplatysmal. Both samples are sent for intraoperative frozen section examination, which results in the diagnosis of cancer-free findings in both cases. Due to the infiltration of the laryngeal skeleton at the level of the thyroid cartilage as demonstrated by computed tomography, it is decided to resect the prelaryngeal musculature in the laryngeal specimen. This is then cut caudally at the level of the cricoid cartilage and cranially at the level of the hyoid bone and removed in the laryngeal preparation. The hyoid bone is then skeletonized and the thyroid cartilage is skeletonized at its posterior edge on both sides. Care is taken to ensure that the prelaryngeal musculature with the thyroid cartilage is also removed in the preparation. Subperichondral dissection on the inner surface of the thyroid cartilage on both sides and maximum protection of the piriform sinus on its outer side. Subsequent exposure of the free epiglottis margin and median pharyngotomy. Dissection along the lateral edges of the epiglottis and the aryepiglottic folds on both sides. Maximum protection of the pharyngeal mucosa in the area of the piriform sinus from cranial to caudal on both sides. Transverse mucosal incision in the postcricoid area, joining the lateral incisions with this transverse incision and entering the region between the posterior wall of the trachea and the anterior wall of the esophagus. Dissection caudally in this layer. Repeated hemostasis using bipolar coagulation. Dissection of the thyroid gland from the side wall of the trachea on both sides. Dissection revealed that the tracheostoma had been inserted between the 1st and 2nd tracheal cartilage clasp and thus clearly in the area of subglottic tumor spread. Decision to remove the former tracheostoma in the tumor preparation. Exposure of the anterior tracheal wall caudal to the existing tracheostoma and incision between the 3rd and 4th tracheal cartilage clasp. Partial epithelialization of the new tracheostoma at its lower edge. Removal of the laryngeal preparation in toto, which is sent in thread-marked for intraoperative frozen section examination. In addition, the following edge samples are sent for intraoperative examination: Tracheostoma anterior margin, lateral tracheal wall left, lateral tracheal wall right, postcricoid mucosa, base of tongue midline, lateral pharyngeal wall right, lateral pharyngeal wall left. In the last 2 marginal samples and more precisely in their cranial part, CIS parts are then detected during the intraoperative frozen section examination. Thus, generous resection in this region and removal of 2 further marginal samples from the right and left cranial pharyngeal side wall, which were found to be tumor-free by the pathology colleagues in the intraoperative frozen section examination. Hemostasis there by means of bipolar coagulation. Cricopharyngeal myotomy in the typical manner. Subsequent 3-layer pharyngeal suture (thin submucosal connective tissue layer, striated pharyngeal wall musculature, residual prelaryngeal musculature). The pharyngeal suture is then reinforced with several pieces of Tachosil cut to size. Dry conditions, insertion of 2 Redon drains on both sides. Completion of the epithelialization of the tracheostoma at its cranial and lateral edges. Prior to this, the tracheal findings were shown to colleagues and the joint decision was made not to use a Provox prosthesis due to the residual trachea being too far caudally. Two-layer wound closure. Application of a pressure bandage. The procedure was completed without complications. PEG placement was dispensed with in the absence of preoperative surgical information. However, this should certainly be carried out during the course of the operation, especially with regard to the necessary adjuvant therapy. Conclusion: Complete laryngectomy, modified radical neck dissection on both sides of region Ib-V with resection of the right internal jugular vein. Control of the pharyngeal suture by means of X-ray and suture pull on the 10th day requested, rapid presentation of the patient to our tumor board after receipt of the final histology for the purpose of planning further therapy. Due to a lack of information, a PEG was not used in this procedure. \ No newline at end of file diff --git a/539/InvasionFront_CD3_block16_x1_y12_patient539_0.json b/539/InvasionFront_CD3_block16_x1_y12_patient539_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6e3ccd6508f75bed25167f672cd864128dfa0069 --- /dev/null +++ b/539/InvasionFront_CD3_block16_x1_y12_patient539_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4295.7, + "Centroid Y µm": 33993.3, + "Num Detections": 14575, + "Num Negative": 14533, + "Num Positive": 42, + "Positive %": 0.2882, + "Num Positive per mm^2": 18.99 + } +} \ No newline at end of file diff --git a/539/InvasionFront_CD3_block16_x2_y12_patient539_1.json b/539/InvasionFront_CD3_block16_x2_y12_patient539_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b74e957af4f46b93a0d7a39e69e39e0a09375a91 --- /dev/null +++ b/539/InvasionFront_CD3_block16_x2_y12_patient539_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6886.6, + "Centroid Y µm": 34203.1, + "Num Detections": 17662, + "Num Negative": 16582, + "Num Positive": 1080, + "Positive %": 6.115, + "Num Positive per mm^2": 465.08 + } +} \ No newline at end of file diff --git a/539/InvasionFront_CD8_block16_x1_y12_patient539_0.json b/539/InvasionFront_CD8_block16_x1_y12_patient539_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aa1496ff40ea92a8d013ac67e8eb07daed240a8e --- /dev/null +++ b/539/InvasionFront_CD8_block16_x1_y12_patient539_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3267.2, + "Centroid Y µm": 28766.9, + "Num Detections": 5206, + "Num Negative": 5155, + "Num Positive": 51, + "Positive %": 0.9796, + "Num Positive per mm^2": 90.79 + } +} \ No newline at end of file diff --git a/539/InvasionFront_CD8_block16_x2_y12_patient539_1.json b/539/InvasionFront_CD8_block16_x2_y12_patient539_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0cbae680697dd34f6191ad93be7ce3b0bd6d8825 --- /dev/null +++ b/539/InvasionFront_CD8_block16_x2_y12_patient539_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5861.4, + "Centroid Y µm": 28801.7, + "Num Detections": 10412, + "Num Negative": 9371, + "Num Positive": 1041, + "Positive %": 9.998, + "Num Positive per mm^2": 700.37 + } +} \ No newline at end of file diff --git a/539/TumorCenter_CD8_block16_x1_y12_patient539_0.json b/539/TumorCenter_CD8_block16_x1_y12_patient539_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d43cafc8746aa0fb846c775fb5a1d93ba1f8372b --- /dev/null +++ b/539/TumorCenter_CD8_block16_x1_y12_patient539_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3223.3, + "Centroid Y µm": 29834.2, + "Num Detections": 21070, + "Num Negative": 16887, + "Num Positive": 4183, + "Positive %": 19.85, + "Num Positive per mm^2": 1742.3 + } +} \ No newline at end of file diff --git a/539/TumorCenter_CD8_block16_x2_y12_patient539_1.json b/539/TumorCenter_CD8_block16_x2_y12_patient539_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0bb06372ae8a82f6bb4da5055c7f513cc73d86cf --- /dev/null +++ b/539/TumorCenter_CD8_block16_x2_y12_patient539_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 30134.0, + "Num Detections": 23089, + "Num Negative": 20496, + "Num Positive": 2593, + "Positive %": 11.23, + "Num Positive per mm^2": 968.98 + } +} \ No newline at end of file diff --git a/539/history_text.txt b/539/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..84ded3049a8462dea0494fc24980b712d7f155ef --- /dev/null +++ b/539/history_text.txt @@ -0,0 +1 @@ +Mr. has had dysphonia since <2019>. Dysphagia is not present. The vocal fold mobility is unremarkable, the right vocal fold is almost completely covered with restless mucosa, which extends into the anterior commissure. This is an indication for the above-mentioned measures, especially as the patient is difficult to adjust endolaryngeally. CT-graphically no indication of cartilage infiltration. \ No newline at end of file diff --git a/539/icd_codes.txt b/539/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/539/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/539/ops_codes.txt b/539/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dff177eb8da18afbce99e9f2df4b59384f52331d --- /dev/null +++ b/539/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] \ No newline at end of file diff --git a/539/patient_clinical_data.json b/539/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..96a2e2b565b28ddd8db477c0af179f7388169023 --- /dev/null +++ b/539/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/539/patient_pathological_data.json b/539/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0739dc22e928bcd66c47f40bf527b25796508481 --- /dev/null +++ b/539/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "539", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/539/surgery_description.txt b/539/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..31d61ac1d21c6a03fdafe57d74732c17600606c7 --- /dev/null +++ b/539/surgery_description.txt @@ -0,0 +1 @@ +KK-Teilresektion nach Leroux-Robert diff --git a/539/surgery_report.txt b/539/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..31c69c333ba2dbb891921b23592b71e25e3c6747 --- /dev/null +++ b/539/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues. Subsequent insertion of the Kleinsasser D-tube and adjustment of the endolarynx. The right vocal fold up to the vocal process of the arytenoid cartilage is covered by a rough mucous membrane. This leaves the glottis and infiltrates the right side of the morgue sinus and the undersurface of the pouch fold. The restless mucosa ends purely macroscopically in the anterior commissure or slightly to the left of it. The restless mucosa lies against the cartilage but does not appear to infiltrate it. On the left side, the restless mucosa does not so much extend to the glottis as to the subglottis. On the right side, the subglottis is free. Due to the poor adjustability, decision to perform a partial laryngectomy from the outside. Positioning of the patient. Injection of 6 ml local anesthetic with added adrenaline in the prelaryngeal area of the planned incision. Abjode and cover. Zigzag-shaped skin incision with horizontal skin tension lines. Preparation on the larynx. Separation of the prelaryngeal musculature in the linea alba. Incision of the perichondrium and pushing off with the Freer. Opening of the larynx through the thyrofissure in the median line using a circular saw. Dissect the larynx and inspect the tumor. This appears as described above. Start on the non-tumor-bearing left side. Separation of the vocal fold and the supraglottis with sufficient safety distance from the tumor. Also removal of the subglottic area. Push the soft tissue away from the thyroid cartilage using a raspatorium. Move to the opposite side after incision of the cricothyroid membrane. Here, too, incision of the tumor, cranial horizontal incision in the upper part of the pocket fold up to the vocal process of the arytenoid cartilage, which is exposed at the end of the operation. Resection of the right vocal fold, subglottic resection with sufficient safety margin. Also here, removal of the thyroid cartilage and retrieval of the complete tumor specimen. Finally, marginal samples are taken supraglottically from the wound bed and subglottically, all of which are found to be tumor-free in the frozen section. As far as possible, a Kleinsasser mucosal flap is sutured to the still existing soft tissue on the right side. The patient receives 2 g ceftriaxone during the operation. Closure of the ligamentum conicum with 3.0 Vicryl sutures. In addition, connection to the inferior edge of the thyroid cartilage, after creation of suture-absorbing holes with the Lindemann reamer. Insertion of a 16 mm Keel and drilling of corresponding holes in the thyroid cartilage. Readaptation, with insertion of the Keel and closure of the thyrofissure. Readaptation of the periochondrium as far as possible and adaptation of the overlying musculature. Subcutaneous suture, with reconstruction of the intended skin incision. Skin suture with 6.0 Prolene. Prior to this, insertion of a flap to prevent air emphysema. Dressing applied. Completion of the procedure without any indication of complications. Conclusion: R0-resected cT2 glottic carcinoma on both sides, right-sided. Please continue Ceftriaxone for the entire duration of hospitalization. \ No newline at end of file diff --git a/540/InvasionFront_CD3_block9_x3_y10_patient540_0.json b/540/InvasionFront_CD3_block9_x3_y10_patient540_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cc5694104319628c2b19df6d4b06524ceb1a3705 --- /dev/null +++ b/540/InvasionFront_CD3_block9_x3_y10_patient540_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11568.9, + "Centroid Y µm": 25886.3, + "Num Detections": 23742, + "Num Negative": 21207, + "Num Positive": 2535, + "Positive %": 10.68, + "Num Positive per mm^2": 946.86 + } +} \ No newline at end of file diff --git a/540/InvasionFront_CD3_block9_x4_y10_patient540_1.json b/540/InvasionFront_CD3_block9_x4_y10_patient540_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d067c518264ae8d1e5d7c33253c0b466d980fbcf --- /dev/null +++ b/540/InvasionFront_CD3_block9_x4_y10_patient540_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 26186.1, + "Num Detections": 30687, + "Num Negative": 27513, + "Num Positive": 3174, + "Positive %": 10.34, + "Num Positive per mm^2": 1123.1 + } +} \ No newline at end of file diff --git a/540/InvasionFront_CD8_block9_x3_y10_patient540_0.json b/540/InvasionFront_CD8_block9_x3_y10_patient540_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14559056f1a8c6f7e62f459b9814e80c8bcd8ad9 --- /dev/null +++ b/540/InvasionFront_CD8_block9_x3_y10_patient540_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11643.8, + "Centroid Y µm": 29459.4, + "Num Detections": 25321, + "Num Negative": 22047, + "Num Positive": 3274, + "Positive %": 12.93, + "Num Positive per mm^2": 1245.2 + } +} \ No newline at end of file diff --git a/540/InvasionFront_CD8_block9_x4_y10_patient540_1.json b/540/InvasionFront_CD8_block9_x4_y10_patient540_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a48e9b880079a0a8500c6cd5d17f986b69df3b8 --- /dev/null +++ b/540/InvasionFront_CD8_block9_x4_y10_patient540_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14492.3, + "Centroid Y µm": 29859.2, + "Num Detections": 36498, + "Num Negative": 32725, + "Num Positive": 3773, + "Positive %": 10.34, + "Num Positive per mm^2": 1347.6 + } +} \ No newline at end of file diff --git a/540/TumorCenter_CD3_block9_x3_y10_patient540_0.json b/540/TumorCenter_CD3_block9_x3_y10_patient540_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d439d61e3bc42a9afdfef87af6bc48d38aedded2 --- /dev/null +++ b/540/TumorCenter_CD3_block9_x3_y10_patient540_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 30608.8, + "Num Detections": 19705, + "Num Negative": 18089, + "Num Positive": 1616, + "Positive %": 8.201, + "Num Positive per mm^2": 618.97 + } +} \ No newline at end of file diff --git a/540/TumorCenter_CD3_block9_x4_y10_patient540_1.json b/540/TumorCenter_CD3_block9_x4_y10_patient540_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3a0d2384e93de3b3bd57965e93657583b6e901c2 --- /dev/null +++ b/540/TumorCenter_CD3_block9_x4_y10_patient540_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 30708.7, + "Num Detections": 20694, + "Num Negative": 16939, + "Num Positive": 3755, + "Positive %": 18.15, + "Num Positive per mm^2": 1443.0 + } +} \ No newline at end of file diff --git a/540/TumorCenter_CD8_block9_x3_y10_patient540_0.json b/540/TumorCenter_CD8_block9_x3_y10_patient540_0.json new file mode 100644 index 0000000000000000000000000000000000000000..58b48542426bc1f7bd167d5ac1c639a9268b6d71 --- /dev/null +++ b/540/TumorCenter_CD8_block9_x3_y10_patient540_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11493.9, + "Centroid Y µm": 26261.1, + "Num Detections": 21126, + "Num Negative": 19719, + "Num Positive": 1407, + "Positive %": 6.66, + "Num Positive per mm^2": 547.06 + } +} \ No newline at end of file diff --git a/540/TumorCenter_CD8_block9_x4_y10_patient540_1.json b/540/TumorCenter_CD8_block9_x4_y10_patient540_1.json new file mode 100644 index 0000000000000000000000000000000000000000..31bf64cd9454659d56ebd596c17d7449015ce213 --- /dev/null +++ b/540/TumorCenter_CD8_block9_x4_y10_patient540_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14117.5, + "Centroid Y µm": 26236.1, + "Num Detections": 20645, + "Num Negative": 17843, + "Num Positive": 2802, + "Positive %": 13.57, + "Num Positive per mm^2": 1098.9 + } +} \ No newline at end of file diff --git a/540/history_text.txt b/540/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/540/icd_codes.txt b/540/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..da55c7511d068fc0b0dfe7e6a45d4d38eecf0a89 --- /dev/null +++ b/540/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/540/ops_codes.txt b/540/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85969429108a6d02c02b0e2840af5196e5f9a7f5 --- /dev/null +++ b/540/ops_codes.txt @@ -0,0 +1 @@ +Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion][5-295.xx ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Permanente Tracheotomie[5-312.0 ] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] Vollhautdeckung großflächig Empfängerstelle Unterarm[5-902.68 L] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Weichgaumenteilresektion[5-272.1 ] \ No newline at end of file diff --git a/540/patient_clinical_data.json b/540/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4541f43c264b4b13c292ef0703ba065cf2698290 --- /dev/null +++ b/540/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 50, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 45, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/540/patient_pathological_data.json b/540/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1df8493275ceb4f5a15a8bce941a7e24bad04da2 --- /dev/null +++ b/540/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "540", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/540/surgery_description.txt b/540/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d400b05d2f6a0e9d838041949432277304434fd --- /dev/null +++ b/540/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion, Neck diss., Defektdeckung, Freier Lappen (Radialis), Tracheotomie, PEG-Anlage diff --git a/540/surgery_report.txt b/540/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1d5cf03e22d6593653566ad95ef78d284e1afaf --- /dev/null +++ b/540/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by anesthesia colleagues. First PEG insertion in the usual manner using the thread pull-through method. In this case, PEG insertion is successful with good diaphanoscopy. Insertion of the spandex and looping of the tongue and inspection of the tumor. The tumor is located on the right side wall of the oropharynx, starting at the anterior palatal arch and passing onto the tonsil as well as at the edge of the base of the tongue on the right. The mucosa around the tumor is incised with a monopolar needle and then the tumor is successively removed with scissors and bipolar forceps as far as possible from the upper transoral area. The tumor itself extends very far laterally into the soft tissues of the neck, so the remaining part must then be removed transcervically. Start with the neck dissection on the left side. Skin incision in a preformed skin fold across the neck, three transverse fingers below the lower jaw. Initial exposure of the platysma. Formation of a platysma flap cranially. Exposure of the sternocleidomastoid and the omohyoid, the cervical vascular sheath and free preparation of the internal jugular vein. Resection of the neck block II to V, sparing the plexus branches and the hypoglossal nerve as well as the facial vein. Removal of the submandibular gland and transection of the digastric muscle to gain access to the oropharynx. Residual resection of the tumor and formation of an enoral bridge. The tumor is sent for final histology and samples are taken from all the margins for frozen section without the pathologist being able to find carcinoma or carcinoma in situ. Neck dissection is performed on the right side. For this purpose, a transverse skin incision is also made on the neck. Exposure of the platysma. Formation of a platysma flap. Exposure of the sternocleidomastoid and omohyoid. Exposure of the cervical vascular sheath. Free preparation of the internal jugular vein. Removal of the neck preparation II a to V a, sparing all nerves and vessels except for the external jugular vein, which is ligated. The submandibular gland is left on this side. Despite everything, level I is also removed on both sides, as the tumor has partly spread to the anterior floor of the mouth. Repositioning to elevate the radialis graft. Marking of the graft and the skin incision. A 5 x 7 cm incision is made around the graft. First dissection of the venous plexus in the crook of the elbow. A good superficial and deep venous system with a relatively weak confluence can be seen. Then visualization of the brachialis muscle and the superficial venous system. Integration of a superficial vein into the graft. Exposure of the superficial ramus, radial nerve. Exposure of the radial artery and repositioning of this. Lifting of the radialis graft first from the lateral, then from the medial side. Dissection of the pedicle with clipping or bipolar coagulation of outflows. Deposition of the graft in the crook of the elbow, leaving one superficial and one deep vein for the connection. Insertion of the graft into the oropharynx and suturing of the graft from the soft palate and transcervically into the oropharynx. Suturing is extremely difficult as the tongue is very swollen and must be done mostly transcervically. Repositioning for anastomosis of the vessels. First dissection of the superior thyroid artery as the connecting vessel from the neck. Dissection of the radial artery on the graft and anastomosis of this. This has to be performed twice, as the flow was too low the first time, but the second time the blood flow to the graft was satisfactory with clearly good return flow in both graft veins. For this, the facial vein is taken once and another small accompanying vein, both of which are anastomosed using a coupler. Positioning of the pedicle with the help of Gelita and insertion of a Redon drain on both sides as well as two-layer skin closure. A tracheotomy is performed in the usual manner using the visor technique at the same time as the forearm is being sutured. Skin incision below the cricoid cartilage. Dissection down to the musculature. Pushing the muscles aside. Exposure of the thyroid gland. Separation of the thyroid isthmus. Exposure of the anterior wall of the trachea. Insertion between the second and third tracheal cartilage. Formation of a mucocutaneous anastomosis in the upper and lower part. Removal of the full-thickness skin from the groin in the usual manner. Insertion of a Redon drain in the groin and two-layer wound closure. The full-thickness skin is thinned and transplanted to the defect on the arm. On the arm, adaptation of the wound edges in the upper part. The full-thickness skin is sutured into the defect area with single button sutures. Perforation of the full-thickness skin and application of a VAC dressing. Apply a pressure of 75 mm Hg to the VAC dressing. Re-intubation and transfer of the patient to the intensive care unit on mechanical ventilation. Continue antibiotics for 24 hours. Regular daily graft checks and clinical diet build-up, without X-ray emesis, on the 10th postoperative day. Presentation of the patient at the tumor conference after receipt of the histology. \ No newline at end of file diff --git a/541/InvasionFront_CD3_block20_x5_y2_patient541_0.json b/541/InvasionFront_CD3_block20_x5_y2_patient541_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6fe75698f69f4b6dfe860629aa02d1cc870d3cd4 --- /dev/null +++ b/541/InvasionFront_CD3_block20_x5_y2_patient541_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17990.5, + "Centroid Y µm": 5215.3, + "Num Detections": 15791, + "Num Negative": 15533, + "Num Positive": 258, + "Positive %": 1.634, + "Num Positive per mm^2": 164.51 + } +} \ No newline at end of file diff --git a/541/InvasionFront_CD3_block20_x6_y2_patient541_1.json b/541/InvasionFront_CD3_block20_x6_y2_patient541_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5a9764f5b8a2f84affd97ecdb91c8dc618ad72b5 --- /dev/null +++ b/541/InvasionFront_CD3_block20_x6_y2_patient541_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20289.3, + "Centroid Y µm": 5722.0, + "Num Detections": 17920, + "Num Negative": 17288, + "Num Positive": 632, + "Positive %": 3.527, + "Num Positive per mm^2": 316.52 + } +} \ No newline at end of file diff --git a/541/InvasionFront_CD8_block20_x5_y2_patient541_0.json b/541/InvasionFront_CD8_block20_x5_y2_patient541_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ec77993b2c6f1780af017c350404e3439e9e2874 --- /dev/null +++ b/541/InvasionFront_CD8_block20_x5_y2_patient541_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 4789.0, + "Num Detections": 16228, + "Num Negative": 15951, + "Num Positive": 277, + "Positive %": 1.707, + "Num Positive per mm^2": 174.5 + } +} \ No newline at end of file diff --git a/541/InvasionFront_CD8_block20_x6_y2_patient541_1.json b/541/InvasionFront_CD8_block20_x6_y2_patient541_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eb6782dc341353cb0f5856d5dbf78571ac98966c --- /dev/null +++ b/541/InvasionFront_CD8_block20_x6_y2_patient541_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18596.3, + "Centroid Y µm": 4993.2, + "Num Detections": 17485, + "Num Negative": 16718, + "Num Positive": 767, + "Positive %": 4.387, + "Num Positive per mm^2": 397.11 + } +} \ No newline at end of file diff --git a/541/TumorCenter_CD3_block20_x5_y2_patient541_0.json b/541/TumorCenter_CD3_block20_x5_y2_patient541_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a528dd89724a6d57f3670a81cee83e07d50d5715 --- /dev/null +++ b/541/TumorCenter_CD3_block20_x5_y2_patient541_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16417.9, + "Centroid Y µm": 4745.5, + "Num Detections": 12479, + "Num Negative": 12471, + "Num Positive": 8, + "Positive %": 0.0641, + "Num Positive per mm^2": 5.252 + } +} \ No newline at end of file diff --git a/541/TumorCenter_CD3_block20_x6_y2_patient541_1.json b/541/TumorCenter_CD3_block20_x6_y2_patient541_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bb74a435811d60033933ae4d6c885cd88c4ab268 --- /dev/null +++ b/541/TumorCenter_CD3_block20_x6_y2_patient541_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18939.3, + "Centroid Y µm": 4443.7, + "Num Detections": 15368, + "Num Negative": 15238, + "Num Positive": 130, + "Positive %": 0.8459, + "Num Positive per mm^2": 73.07 + } +} \ No newline at end of file diff --git a/541/TumorCenter_CD8_block20_x5_y2_patient541_0.json b/541/TumorCenter_CD8_block20_x5_y2_patient541_0.json new file mode 100644 index 0000000000000000000000000000000000000000..16ec80aad8d96284842703fffc2ea33704971069 --- /dev/null +++ b/541/TumorCenter_CD8_block20_x5_y2_patient541_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15366.9, + "Centroid Y µm": 4997.4, + "Num Detections": 15264, + "Num Negative": 15264, + "Num Positive": 0, + "Positive %": 0.0, + "Num Positive per mm^2": 0.0 + } +} \ No newline at end of file diff --git a/541/TumorCenter_CD8_block20_x6_y2_patient541_1.json b/541/TumorCenter_CD8_block20_x6_y2_patient541_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ee72bc65cbee0b1a7a6c7e15f5202c87c86216cd --- /dev/null +++ b/541/TumorCenter_CD8_block20_x6_y2_patient541_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17915.5, + "Centroid Y µm": 4722.5, + "Num Detections": 11622, + "Num Negative": 11222, + "Num Positive": 400, + "Positive %": 3.442, + "Num Positive per mm^2": 284.71 + } +} \ No newline at end of file diff --git a/541/history_text.txt b/541/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/541/icd_codes.txt b/541/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..027913dd960ff6d16d2ba7a91adad34e8477c05d --- /dev/null +++ b/541/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] Kehlkopfknorpelkarzinom[C32.3 B] \ No newline at end of file diff --git a/541/ops_codes.txt b/541/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc3b1a7f84cc754c60d4d3f4e8c3aa2418d49c97 --- /dev/null +++ b/541/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Radikale Neck dissection in 5 Regionen[5-403.11 R] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 L] Permanente Tracheotomie[5-312.0 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.x1 ] \ No newline at end of file diff --git a/541/patient_clinical_data.json b/541/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..640b1a8cfcf226369075a2527f1e5db5d891e5e5 --- /dev/null +++ b/541/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/541/patient_pathological_data.json b/541/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f6f6433faf516b673b37ad75ea1681d252672423 --- /dev/null +++ b/541/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "541", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4b", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 10.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "1.3", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 30.0 +} \ No newline at end of file diff --git a/541/surgery_description.txt b/541/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5752a61e53ecc3731970c217f6dc8c865e12f55d --- /dev/null +++ b/541/surgery_description.txt @@ -0,0 +1 @@ +Laryngektomie, Neck diss., Tracheotomie, Provox-Prothese diff --git a/541/surgery_report.txt b/541/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7aade2ce9ebdf51b603ea162da23e3ce0fd51808 --- /dev/null +++ b/541/surgery_report.txt @@ -0,0 +1 @@ +Bronchoscopic intubation by anesthesia colleagues. This proved to be extremely difficult as the supraglottic tumor masses almost completely obstructed the pharyngeal and laryngeal entrance. After laborious attempts, a tube was finally placed. Performing pharyngoscopy and laryngoscopy with the small bore tube. The tumor described above can be seen in the area of the epiglottis. The epiglottis is completely consumed, the tumor extends over both aryepiglottic folds to the arytenoid cartilage, on the right side the arytenoid cartilage is completely infiltrated, on the left side it extends to the arytenoid cartilage. The pocket folds are infiltrated on both sides and the lateral edge of the vocal fold is also infiltrated on the right side. Then injection of Ultracaine and sterile washing and covering. Creation of an apron flap in the usual manner. Start with neck dissection on the right side. This shows several large metastases in the area of the sternocleidomastoid muscle and the cervical vascular sheath. First visualization of the submandibular gland and the omohyoid muscle. Visualization of the digaster and hypoglossus. The metastases cannot be detached from the sternocleidomastoid muscle, nor from the internal jugular vein. The common carotid artery is displaced far to the dorsolateral side. Now switch to the left side in order to obtain the internal jugular vein. Expose the sternocleidomastoid muscle, the submandibular gland and the omohyoid muscle. Then expose the cervical vascular sheath. Dissection of the internal jugular vein and detachment of the neck preparation from the cervical vascular sheath. Several large metastases here too. Here, the larynx is first dissected by detaching the thyroid gland, the superior thyroid artery and severing the upper laryngeal bundle. Detachment of the oblique laryngeal muscles. Change to the opposite side. Continuation of the neck dissection by separating the sternocleidomastoid muscle at the lower attachment. It can be seen that a large metastatic conglomerate extends below the clavicle. Careful dissection here. Separation of the internal jugular vein and high dissection of the conglomerate, detaching it from the common carotid artery and later from the bulb. The sternocleidomastoid muscle is also severed in the upper part. The accessorius nerve can be preserved here. Separation of the internal jugular vein and removal of the large metastatic conglomerate. Then removal of the remaining fatty tissue from level II b, sparing the plexus branches. Level VI was integrated into the metastatic conglomerate. Now release of the larynx. Detachment of the oblique laryngeal muscles. Separation of the laryngeal bundle. Detachment of the thyroid gland and the cervical vascular sheath at the larynx. Detachment of the hyoid bone at the base of the tongue. Integration of the hyoid bone into the laryngeal preparation. Now perform the tracheotomy. For this, insertion between the 1st and 2nd tracheal cartilage and reintubation onto a laryngectomy tube. Now release the piriform sinus, first on the right side, then on the left side, in the usual manner. This must be done very carefully so as not to ........ into the tumor. Then enter the pharynx from the left side. This must be done relatively high up, as the tumor is a supraglottic laryngeal carcinoma with complete infiltration or consumption of the epiglottis. This is then carefully dislocated upwards. Then incision of the mucosa along the epiglottis borders up to the postcricoid region on the left side, then the same on the right side, while sparing the piriform sinus. Now place the larynx below the cricoid cartilage. Suture marking. Taking marginal samples. The marginal sample of the lateral pharyngeal wall still shows carcinoma in situ in the center. A resection was performed and a final margin sample was taken. Final complete R0 situation. In the meantime, a Provox prosthesis of size 8.0 was placed in the usual manner using the pull-through method. Then, in the meantime, completion of the neck dissection on the left side by . For this purpose, the neck preparation was removed while sparing the plexus branches and the accessorius nerve at level II a to V a. The internal jugular vein and superior thyroid artery were preserved. Now start with the pharyngeal suture, initially in the base of the tongue with creation of a small T, but the mucosa is very dilapidated and begins to tear towards the oropharynx on both sides. Intraoperative demonstration to . He recommends reopening the previously sutured pharyngeal suture and starting again. This is also the same as the first time with the same result that the mucosa tears again and again due to maceration. Finally, the mucosa in the area of the oropharynx must be sutured transorally and then the pharyngeal suture must be sutured in the usual manner, first in the area of the base of the tongue and then in the area of the mucosa in two layers with single button sutures. Finally, readaptation of the pharyngeal muscles so that no laryngeal stenosis occurs. Then incision of the tracheostoma and creation of a mucocutaneous anastomosis and reintubation to a 10 mm tracheostomy tube. Two 10-gauge Redon drains were inserted beforehand and the procedure was completed with a two-layer wound closure. Please check the wound daily and open the throat extensively if a fistula occurs. The risk of fistula is greatly increased in this patient due to the difficult pharyngeal-mucosal conditions. A nasogastric tube is not inserted so that no additional foreign material is placed in the affected pharyngeal mucosa. X-ray gruel swallow on the 12th postoperative day. Continuation of antibiotics for 1 week. \ No newline at end of file diff --git a/542/InvasionFront_CD3_block6_x1_y6_patient542_0.json b/542/InvasionFront_CD3_block6_x1_y6_patient542_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c43442d1700c4db25f81c588ce22d3d6eeaeaf97 --- /dev/null +++ b/542/InvasionFront_CD3_block6_x1_y6_patient542_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4547.6, + "Centroid Y µm": 15192.0, + "Num Detections": 27116, + "Num Negative": 19748, + "Num Positive": 7368, + "Positive %": 27.17, + "Num Positive per mm^2": 2684.3 + } +} \ No newline at end of file diff --git a/542/InvasionFront_CD3_block6_x2_y6_patient542_1.json b/542/InvasionFront_CD3_block6_x2_y6_patient542_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4c2b66fd8a69e4ff8fac0e621f7259d07efecd4d --- /dev/null +++ b/542/InvasionFront_CD3_block6_x2_y6_patient542_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7271.2, + "Centroid Y µm": 15341.9, + "Num Detections": 26864, + "Num Negative": 20958, + "Num Positive": 5906, + "Positive %": 21.98, + "Num Positive per mm^2": 2141.8 + } +} \ No newline at end of file diff --git a/542/InvasionFront_CD8_block6_x1_y4_patient542_0.json b/542/InvasionFront_CD8_block6_x1_y4_patient542_0.json new file mode 100644 index 0000000000000000000000000000000000000000..702ece42f9006100482b37e0285a2c38d8b185c6 --- /dev/null +++ b/542/InvasionFront_CD8_block6_x1_y4_patient542_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5097.3, + "Centroid Y µm": 9295.1, + "Num Detections": 15161, + "Num Negative": 14984, + "Num Positive": 177, + "Positive %": 1.167, + "Num Positive per mm^2": 98.19 + } +} \ No newline at end of file diff --git a/542/InvasionFront_CD8_block6_x2_y4_patient542_1.json b/542/InvasionFront_CD8_block6_x2_y4_patient542_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3f0e31219bd9d737c2146950797dd62dc1b2977f --- /dev/null +++ b/542/InvasionFront_CD8_block6_x2_y4_patient542_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7546.0, + "Centroid Y µm": 9470.0, + "Num Detections": 19887, + "Num Negative": 19853, + "Num Positive": 34, + "Positive %": 0.171, + "Num Positive per mm^2": 14.26 + } +} \ No newline at end of file diff --git a/542/TumorCenter_CD3_block6_x1_y4_patient542_0.json b/542/TumorCenter_CD3_block6_x1_y4_patient542_0.json new file mode 100644 index 0000000000000000000000000000000000000000..41ee0905de4760a91b1b8f8704de75779f8254e9 --- /dev/null +++ b/542/TumorCenter_CD3_block6_x1_y4_patient542_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3947.9, + "Centroid Y µm": 10144.6, + "Num Detections": 11827, + "Num Negative": 11636, + "Num Positive": 191, + "Positive %": 1.615, + "Num Positive per mm^2": 106.58 + } +} \ No newline at end of file diff --git a/542/TumorCenter_CD3_block6_x2_y4_patient542_1.json b/542/TumorCenter_CD3_block6_x2_y4_patient542_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69fdd311906c250a5084e8fe15e42627f5dc4a77 --- /dev/null +++ b/542/TumorCenter_CD3_block6_x2_y4_patient542_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 10169.6, + "Num Detections": 18244, + "Num Negative": 17285, + "Num Positive": 959, + "Positive %": 5.257, + "Num Positive per mm^2": 413.81 + } +} \ No newline at end of file diff --git a/542/TumorCenter_CD8_block6_x1_y4_patient542_0.json b/542/TumorCenter_CD8_block6_x1_y4_patient542_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1d33ee9313263a5ee86e2b872bd74c6b31263d96 --- /dev/null +++ b/542/TumorCenter_CD8_block6_x1_y4_patient542_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 10319.5, + "Num Detections": 14788, + "Num Negative": 14785, + "Num Positive": 3, + "Positive %": 0.0203, + "Num Positive per mm^2": 1.342 + } +} \ No newline at end of file diff --git a/542/TumorCenter_CD8_block6_x2_y4_patient542_1.json b/542/TumorCenter_CD8_block6_x2_y4_patient542_1.json new file mode 100644 index 0000000000000000000000000000000000000000..302a2be86231bfe3d574d01c8a5a0e4cd9c3c04e --- /dev/null +++ b/542/TumorCenter_CD8_block6_x2_y4_patient542_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 10469.5, + "Num Detections": 20520, + "Num Negative": 20137, + "Num Positive": 383, + "Positive %": 1.866, + "Num Positive per mm^2": 159.64 + } +} \ No newline at end of file diff --git a/542/history_text.txt b/542/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/542/icd_codes.txt b/542/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/542/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/542/ops_codes.txt b/542/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a78d30958bb40bcf5e330ae47fe429c08e06edb8 --- /dev/null +++ b/542/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] Hand[5-858.04 L] Lappenplastik an Haut und Unterhaut, Entnahmestelle: Freier Lappen mit mikrovaskulärer Anastomosierung: Hals[5-904.05 ] Biopsie an anderen Strukturen des Mundes und der Mundhöhle durch Inzision: Sonstige[1-545.x ] Pharyngoplastik: Mit mikrovaskulär anastomosiertem Transplantat[5-293.2 ] \ No newline at end of file diff --git a/542/patient_clinical_data.json b/542/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8bb6013469b4fdb16475f936f63590b4774d9f2c --- /dev/null +++ b/542/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2008, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/542/patient_pathological_data.json b/542/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..15ffd3504c209610e09bcf629141f6117fda5b64 --- /dev/null +++ b/542/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "542", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/542/surgery_description.txt b/542/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..22f28eb2afff93137962b2b8510b4d665b07480f --- /dev/null +++ b/542/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion, Neck dissection bds, Defektdeckung, Freier Lappen (Radialis), Tracheotomie diff --git a/542/surgery_report.txt b/542/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..094b478feddc8014267e83639b61e17da4719b67 --- /dev/null +++ b/542/surgery_report.txt @@ -0,0 +1 @@ +First, the oral cavity and oropharynx are opened up: the tumor is revealed, covering the soft palate and both tonsil regions in the area of the upper third on both sides. Now the tumor is successively excised in toto with the electric knife, starting from the top, with attached tonsils. Subsequently, marginal samples are taken from the area of the margin, in the area of the soft palate cranially, laterally, left and right and from the area of the left tubal region, as a hyperdense mass was found there on CT. All marginal samples are free of carcinoma in the frozen section diagnosis. Now perform the neck dissection on the left: Incision in the area of the front edge of the sternocleidomastoid muscle, caudal exposure of the jugular vein, the common carotid artery and the vagus nerve. The lateral neck dissection preparation is now developed from caudal to cranial for 2, 3 cm. The digaster muscle and the hypoglossal nerve are now explored cranially. A large metastasis in the area of the venous angle on the left can be dissected with difficulty from the cervical vascular sheath and cranially. This mass has impacted the accessorius nerve so that it has to be partially resected. Now explore the carotid bifurcation medially. Expose the superior thyroid artery, the lingual artery and the ascending pharyngeal artery. Neck dissection on the opposite side: incision in the area of the front edge of the sternocleidomastoid muscle. Caudal exposure of the common carotid artery, the jugular vein and the vagus nerve. The lateral neck dissection specimen is now dissected cranially for approx. 2 to 3 cm. Cranially expose the digaster muscle, the hypoglossal nerve and the accessorius nerve. The lateral neck dissection specimen is now removed in toto from cranial to caudal while protecting the cervical nerve plexi as much as possible. Medial view of the carotid bifurcation. Exposure of the superior thyroid. Now tracheotomy: Transverse skin incision 2 transverse fingers below the thyroid cartilage. Cut through the subcutaneous tissue. Exposure of the thyroid isthmus, clamping of the same, left and right transection of the same. The trachea is now incised between the 2nd and 3rd tracheal cartilage, a Björk flap is formed and the trachea is sutured to the skin in a stable manner. Now lift the radial flap. For this purpose, a corresponding skin area is painted on in the area of the palmar / forearm surface. The radial flap is now developed from the ulna in the form of a fasciocutaneous flap. The radial artery and radial nerve are now shown laterally. The radial artery is clamped with a vascular clamp. The radialis flap is now lifted as a fasciocutaneous flap and traced along the radial artery and the two accompanying veins into the elbow joint. There, the interosseous artery and the confluence sinuum of the accompanying venous plexuses are identified. The radial artery is now removed caudally and cranially. The accompanying veins are also removed. Then perfuse the harvested microvascular graft with heparin. The defect in the area of the forearm is then primarily covered. A full-thickness skin graft is then harvested from the area of the right groin. Oval incision of the skin region in the area of the right groin. Incision of the subcutaneous tissue. The skin area is then harvested in toto from the right groin. Smaller bleedings are coagulated, larger ones are stopped. A Redon drain is then placed. Subcutaneous suture. Skin suture. The removed skin is then freed from adherent fatty tissue and sutured into the defect in the left forearm as a split-thickness skin graft. The graft is then fitted into the soft palate. The transplant is sufficiently large. Communication is established with the right neck and the right oropharynx by bluntly entering the oral cavity/oropharynx after cutting through the digaster muscle. The stem of the transplant is then carefully pulled through this perforation into the neck. The radialis flap is then sutured into the defect. The radial artery flap is then microvascularly anastomosed by suturing the superior thyroid artery end-to-end with the facial artery and anastomosing the accompanying venous plexuses (confluens sinuum) end-to-side with the internal jugular vein. No evidence of leakage of the vascular anastomoses after removal of the vascular clamps. Careful irrigation of the wound. Placement of Redon drains on the right cervical and left cervical side. Subcutaneous suture, skin suture of the neck dissection incision on the right and left. Sterile wound dressing. Completion of the operation. Conclusion: Enormous tumor resection of a cT3 oral cavity oropharyngeal carcinoma, neck dissection on both sides, tracheotomy. Removal of a vascularized radial flap on the left and microvascular anastomosis of the flap on the right. The patient is admitted to the intensive care unit of our hospital postoperatively. Please continue antibiotics Unacid, 3 x 3 g. After receiving the definitive histology, the patient should be presented to the interdisciplinary tumor conference at our hospital. \ No newline at end of file diff --git a/543/InvasionFront_CD3_block3_x5_y3_patient543_0.json b/543/InvasionFront_CD3_block3_x5_y3_patient543_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bdaecfdf377d1674d1f2a50f26c3a720a0d55fbb --- /dev/null +++ b/543/InvasionFront_CD3_block3_x5_y3_patient543_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 12568.3, + "Num Detections": 21006, + "Num Negative": 18821, + "Num Positive": 2185, + "Positive %": 10.4, + "Num Positive per mm^2": 961.75 + } +} \ No newline at end of file diff --git a/543/InvasionFront_CD3_block3_x6_y3_patient543_1.json b/543/InvasionFront_CD3_block3_x6_y3_patient543_1.json new file mode 100644 index 0000000000000000000000000000000000000000..44dbb4067ee6729ebc8f46086581793ec224d41c --- /dev/null +++ b/543/InvasionFront_CD3_block3_x6_y3_patient543_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21513.6, + "Centroid Y µm": 12468.4, + "Num Detections": 19015, + "Num Negative": 16031, + "Num Positive": 2984, + "Positive %": 15.69, + "Num Positive per mm^2": 1362.5 + } +} \ No newline at end of file diff --git a/543/InvasionFront_CD8_block3_x5_y3_patient543_0.json b/543/InvasionFront_CD8_block3_x5_y3_patient543_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0c760aec57dd9e34092c558e03bc7f1c5a12bc3b --- /dev/null +++ b/543/InvasionFront_CD8_block3_x5_y3_patient543_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17516.4, + "Centroid Y µm": 7149.9, + "Num Detections": 23563, + "Num Negative": 21312, + "Num Positive": 2251, + "Positive %": 9.553, + "Num Positive per mm^2": 893.39 + } +} \ No newline at end of file diff --git a/543/InvasionFront_CD8_block3_x6_y3_patient543_1.json b/543/InvasionFront_CD8_block3_x6_y3_patient543_1.json new file mode 100644 index 0000000000000000000000000000000000000000..af62ba579f0e4b906cd72f88a3f8343852e3469e --- /dev/null +++ b/543/InvasionFront_CD8_block3_x6_y3_patient543_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20121.2, + "Centroid Y µm": 7060.4, + "Num Detections": 24552, + "Num Negative": 21726, + "Num Positive": 2826, + "Positive %": 11.51, + "Num Positive per mm^2": 1118.0 + } +} \ No newline at end of file diff --git a/543/TumorCenter_CD3_block3_x5_y3_patient543_0.json b/543/TumorCenter_CD3_block3_x5_y3_patient543_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e457ed344d0895715f4d2e2016aab28ead46c891 --- /dev/null +++ b/543/TumorCenter_CD3_block3_x5_y3_patient543_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15971.7, + "Centroid Y µm": 13775.5, + "Num Detections": 8156, + "Num Negative": 5675, + "Num Positive": 2481, + "Positive %": 30.42, + "Num Positive per mm^2": 2522.4 + } +} \ No newline at end of file diff --git a/543/TumorCenter_CD3_block3_x6_y3_patient543_1.json b/543/TumorCenter_CD3_block3_x6_y3_patient543_1.json new file mode 100644 index 0000000000000000000000000000000000000000..51d80ec2efc2b25c068235c76242c52aaa0f8d18 --- /dev/null +++ b/543/TumorCenter_CD3_block3_x6_y3_patient543_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18804.0, + "Centroid Y µm": 13779.9, + "Num Detections": 12520, + "Num Negative": 9132, + "Num Positive": 3388, + "Positive %": 27.06, + "Num Positive per mm^2": 2239.3 + } +} \ No newline at end of file diff --git a/543/TumorCenter_CD8_block3_x5_y3_patient543_0.json b/543/TumorCenter_CD8_block3_x5_y3_patient543_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2dc36e25797919e99c302fc79a4f4cb7c2be6a13 --- /dev/null +++ b/543/TumorCenter_CD8_block3_x5_y3_patient543_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17240.9, + "Centroid Y µm": 9270.1, + "Num Detections": 24351, + "Num Negative": 21336, + "Num Positive": 3015, + "Positive %": 12.38, + "Num Positive per mm^2": 1198.4 + } +} \ No newline at end of file diff --git a/543/TumorCenter_CD8_block3_x6_y3_patient543_1.json b/543/TumorCenter_CD8_block3_x6_y3_patient543_1.json new file mode 100644 index 0000000000000000000000000000000000000000..31771c1ed66e5873d16820cdcd4ebb952765a5b2 --- /dev/null +++ b/543/TumorCenter_CD8_block3_x6_y3_patient543_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19839.5, + "Centroid Y µm": 9370.0, + "Num Detections": 26100, + "Num Negative": 23274, + "Num Positive": 2826, + "Positive %": 10.83, + "Num Positive per mm^2": 1135.7 + } +} \ No newline at end of file diff --git a/543/history_text.txt b/543/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d4820a7eb96a043c0295bb8690734867dce76e0 --- /dev/null +++ b/543/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma in the tonsil region. The above-mentioned surgery was therefore indicated. There is also cN1 status on the right. \ No newline at end of file diff --git a/543/icd_codes.txt b/543/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b813f66c5435e143f5d136b34edada049e2145db --- /dev/null +++ b/543/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Seitenwand des Oropharynx[C10.2 R] \ No newline at end of file diff --git a/543/ops_codes.txt b/543/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b444143fb2356719ed2e18315e415c4f7d8019e --- /dev/null +++ b/543/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx ohne Rekonstruktion[5-296.00 ] Temporäre Tracheotomie[5-311.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Selektive Neck dissection in 3 Regionen[5-403.02 L] \ No newline at end of file diff --git a/543/patient_clinical_data.json b/543/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b2981764cfc39fb6f6114cd9f656a0742c07f04e --- /dev/null +++ b/543/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 58, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/543/patient_pathological_data.json b/543/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..98403891edc012b74f9aafbf7b65277a7337fca1 --- /dev/null +++ b/543/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "543", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/543/surgery_description.txt b/543/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e4bd35e3d54104716124cf5a27304a8b4dd9f988 --- /dev/null +++ b/543/surgery_description.txt @@ -0,0 +1 @@ +transorale Resektion, Neck Diss., PEG-Anlage diff --git a/543/surgery_report.txt b/543/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d647eaf1782017ffb79230056b08c67378b381a7 --- /dev/null +++ b/543/surgery_report.txt @@ -0,0 +1 @@ +Reclination of the head. Applying the mouth retractor. Exposure of the tumor. Transoral resection: The tumor is incised on all sides with a safety margin of at least 1 to 1.5 cm. The tonsil lobe, anterior palatal arch, mucosa of the glossotonsillar junction and also approx. 25-30% of the right tongue base are removed. The resection extends caudally to the hypopharyngeal entrance. The specimen is thread-marked. After inspection of the tumor specimen, a cranial margin sample is taken from the palatal arch area. Also take a basal-lateral marginal sample from the pharyngeal wall area, behind the tonsillar lobe or in the direction of the glossotonsillar junction. In the frozen section, specimen R0 on all sides, somewhat scarce basally, but now an R0 situation when viewed together with the marginal specimen. Careful hemostasis is performed. During the transoral resection, the lingual artery was stitched and treated with clips. Re-inspection shows clips in situ, no evidence of bleeding. PEG insertion: insertion of the gastroscope. Pre-mirroring into the stomach. After creating a spontaneous diaphanoscopy, insertion of a 15 mm abdominal wall tube in a typical manner without complications. This is also fixed to the abdominal wall in a typical manner. Repositioning for neck dissection on both sides and tracheotomy. First sterile draping after skin disinfection and after injection of a total of 10 ml Ultracaine 1% with adrenaline into both sides of the neck. Beginning with neck dissection on the right: typical skin incision. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid and digastric muscles and infrahyoid muscles. Then exposure of the internal jugular vein, facial vein, internal carotid artery, external carotid artery, submandibular gland, vagus nerve, hypoglossal nerve and accessorius nerve. All structures are preserved. Removal of the larger, clearly malignant suspicious masses as part of the neck preparation. This is followed by a level II to V excision while preserving the branches of the cervical plexus. Finally, careful haemostasis with RZZZ dissolution and layered wound closure with insertion of a Redon drain. Tracheostoma creation: This is performed by . Small Kocher collar incision. Exposure of subcutaneous tissue and transection of this. Veins are ligated. Exposure of the infrahyoid musculature. This is divided. Exposure of thyroid cartilage and thyroid isthmus. Undercutting of the thyroid isthmus, clamping, severing and treatment using puncture ligatures. Subsequent exposure of the trachea. Finally, creation of a broadly pedicled modified Björ flap. This is epithelized in a typical manner. Insertion of a 7 mm tracheal cannula. Neck dissection is then performed on the left through and . Dictation : Marking of the skin incision and careful skin incision and dissection of the subcutaneous fatty tissue. Cut through the platysma and bluntly push the platysma away from the cervical fascia. Start dissection with the sternocleidomastoid muscle. Here the anterior margin is sought out and carefully dissected from the center of the muscle caudally (region IV). This reveals the omohyoid muscle, on whose muscle belly the dissection is carried out further cranially. Sharp dissection of the submandibular gland and elevation of the gland. Below the gland, the digaster muscle is now sought out and followed in the direction of the mastoid. This is done by means of blunt dissection and with protection of the facial vein. Locate the triangle between the omohyoid muscle and the submandibular gland. Clearing out the neck preparation. Careful preliminary work laterally on the omohyoid muscle and medially on the internal jugular vein in order to clear the medial neck preparation. This is achieved without any problems. Move on to the lateral compartment. Here the jugulofacial angle is carefully exposed. Below the vein, the hypoglossal nerve can be seen, which is exposed approx. 1 cm wide and can be spared without any problems. Continue laterally to the upper part of the sternocleidomastoid. The accessorius nerve is located here. Spread in the direction of the nerve and locate the nerve. This is spared. Now continue preparation with level IIb. Here, bipolar coagulation and sharp dissection of the sternocleidomastoid muscle and the digaster to region IIb is performed and the preparation is pulled through under the accessorius nerve. Further dissection caudally at the internal jugular vein. The common carotid artery is also exposed and the vagus nerve is visualized. This is done without any problems and both structures can be spared. Now continue dissection of the lateral compartment from cranial to caudal. The caudal border is defined as the omohyoid muscle, the deep border as the plexus branches. All these structures can be spared. After completion of the dissection of the lateral compartment, there is no evidence of a chyle fistula. The cervical sinus could not be spared. After careful hemostasis with bipolar coagulation, irrigation with H2O2 and Ringer. Insertion of a drain ( 10 ) and two-layer wound closure. Subsequent re-inspection of the wound surface intraorally after insertion of the McIvor spatula. Small areas of mucosal bleeding are still visible. These are stopped. No further bleeding. Stable vascular situation in the area of the clips. Due to the somewhat more extensive resection, exposure and ligation of the lingual artery from the cervical side was omitted, as there would otherwise have been a risk of a fistula. Stable situation at check-up, no bleeding. Completion of the procedure without complications. The patient is admitted to the intensive care unit for postoperative monitoring. Please feed via the PEG system due to the extensive transoral resection. Please continue antibiotics for one week with Unacid, which was given intraoperatively. Overall cT2 cN2b tonsillar carcinoma. Radiotherapy or radiochemotherapy indicated depending on the postoperative findings. \ No newline at end of file diff --git a/544/InvasionFront_CD3_block15_x3_y8_patient544_0.json b/544/InvasionFront_CD3_block15_x3_y8_patient544_0.json new file mode 100644 index 0000000000000000000000000000000000000000..11b4ce9d8c04cc694ca80d8c3aa66c07f9f8a6cd --- /dev/null +++ b/544/InvasionFront_CD3_block15_x3_y8_patient544_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 30084.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/544/InvasionFront_CD3_block15_x4_y8_patient544_1.json b/544/InvasionFront_CD3_block15_x4_y8_patient544_1.json new file mode 100644 index 0000000000000000000000000000000000000000..086b2926356bcecb307e80c95aa4be2bd3fe71e8 --- /dev/null +++ b/544/InvasionFront_CD3_block15_x4_y8_patient544_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 30209.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/544/InvasionFront_CD8_block15_x3_y8_patient544_0.json b/544/InvasionFront_CD8_block15_x3_y8_patient544_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0685e0a4ceeec245e691bc0f196f135eaaad4428 --- /dev/null +++ b/544/InvasionFront_CD8_block15_x3_y8_patient544_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11368.7, + "Centroid Y µm": 19581.3, + "Num Detections": 15630, + "Num Negative": 14850, + "Num Positive": 780, + "Positive %": 4.99, + "Num Positive per mm^2": 372.93 + } +} \ No newline at end of file diff --git a/544/InvasionFront_CD8_block15_x4_y8_patient544_1.json b/544/InvasionFront_CD8_block15_x4_y8_patient544_1.json new file mode 100644 index 0000000000000000000000000000000000000000..910ea0b84e88417fddc44081297bdc78295ac290 --- /dev/null +++ b/544/InvasionFront_CD8_block15_x4_y8_patient544_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14025.8, + "Centroid Y µm": 19559.5, + "Num Detections": 9738, + "Num Negative": 9114, + "Num Positive": 624, + "Positive %": 6.408, + "Num Positive per mm^2": 496.76 + } +} \ No newline at end of file diff --git a/544/TumorCenter_CD3_block15_x3_y8_patient544_0.json b/544/TumorCenter_CD3_block15_x3_y8_patient544_0.json new file mode 100644 index 0000000000000000000000000000000000000000..65d508707dbb3f1e07408c8764e91803d53171c4 --- /dev/null +++ b/544/TumorCenter_CD3_block15_x3_y8_patient544_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 23562.5, + "Num Detections": 15994, + "Num Negative": 12511, + "Num Positive": 3483, + "Positive %": 21.78, + "Num Positive per mm^2": 1708.0 + } +} \ No newline at end of file diff --git a/544/TumorCenter_CD3_block15_x4_y8_patient544_1.json b/544/TumorCenter_CD3_block15_x4_y8_patient544_1.json new file mode 100644 index 0000000000000000000000000000000000000000..053ab3a5c565a016ecd60cbbdf974740d74d9209 --- /dev/null +++ b/544/TumorCenter_CD3_block15_x4_y8_patient544_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 23387.6, + "Num Detections": 18596, + "Num Negative": 15394, + "Num Positive": 3202, + "Positive %": 17.22, + "Num Positive per mm^2": 1369.9 + } +} \ No newline at end of file diff --git a/544/TumorCenter_CD8_block15_x3_y8_patient544_0.json b/544/TumorCenter_CD8_block15_x3_y8_patient544_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a355dc3a448d5f569befeaaf6276100fb479fdc7 --- /dev/null +++ b/544/TumorCenter_CD8_block15_x3_y8_patient544_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13667.8, + "Centroid Y µm": 19964.4, + "Num Detections": 19477, + "Num Negative": 16717, + "Num Positive": 2760, + "Positive %": 14.17, + "Num Positive per mm^2": 1125.4 + } +} \ No newline at end of file diff --git a/544/TumorCenter_CD8_block15_x4_y8_patient544_1.json b/544/TumorCenter_CD8_block15_x4_y8_patient544_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0374a1ac8c58a3b9ceeb2006c9fd9c1ea8b4c2d6 --- /dev/null +++ b/544/TumorCenter_CD8_block15_x4_y8_patient544_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 19914.5, + "Num Detections": 20127, + "Num Negative": 17675, + "Num Positive": 2452, + "Positive %": 12.18, + "Num Positive per mm^2": 991.68 + } +} \ No newline at end of file diff --git a/544/history_text.txt b/544/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b4e0d284bcbb710d8bbf80bbc2031c2a560f85ed --- /dev/null +++ b/544/history_text.txt @@ -0,0 +1 @@ +The patient was diagnosed <2014> with cT2 cN0 tongue margin carcinoma on the right histologically. In our interdisciplinary tumor conference, primary surgical treatment was recommended. \ No newline at end of file diff --git a/544/icd_codes.txt b/544/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cf422e8d9567fdb2464b75d4b6093c8a641ac4db --- /dev/null +++ b/544/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 R] \ No newline at end of file diff --git a/544/ops_codes.txt b/544/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ebb70fefb03ea661898b57d21a6c4a505421954 --- /dev/null +++ b/544/ops_codes.txt @@ -0,0 +1 @@ +Sonstige partielle Glossektomie Rekonstruktion mit gestieltem Fernlappen[5-251.x3 ] Sonstige Pharyngotomie[5-290.x ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 R] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 R] Temporäre Tracheotomie[5-311.0 ] Gestielte regionale Lappenplastik mit Fernlappen an der Schulter[5-906.26 R] PEG-Sonde Anlage[5-431.2 ] \ No newline at end of file diff --git a/544/patient_clinical_data.json b/544/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..45f01e109697f82a363919242a78edd744f1d862 --- /dev/null +++ b/544/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 83, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/544/patient_pathological_data.json b/544/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..67483dcf01db5eb6056527d0820ede8dbcf459bf --- /dev/null +++ b/544/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "544", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 8, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 14.0 +} \ No newline at end of file diff --git a/544/surgery_description.txt b/544/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..25ca8a0049f5a091e18630ce56f2026fdd4563fb --- /dev/null +++ b/544/surgery_description.txt @@ -0,0 +1 @@ +part. Glossektomie, Neck diss., Defektdeckung, Tracheotomie, PEG-Anlage diff --git a/544/surgery_report.txt b/544/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c1850088d05525c342e9da1c380f1dd0ebdd2e19 --- /dev/null +++ b/544/surgery_report.txt @@ -0,0 +1 @@ +First inspection of the primary tumor region. The largely submucosal mass of the right edge of the tongue can be seen, largely as described above, the tip of the tongue is free, measuring a total of approx. 4 cm, some progression towards the lateral floor of the mouth, here too largely submucosal tumor parts, the base of the tongue itself is free dorsally, tumor formation is well displaceable in the tissue. Transoral tumor resection is performed first. Cutting around the tumor process with the monopolar needle or using the dissection technique while maintaining an adequate safety distance in the sense of a hemiglossectomy. Removal of the entire lateral floor of the mouth. Exposure and exposure of the submandibular gland, which itself is not infiltrated. Clear transition to the lateral floor of the mouth, but the tumor is limited to one side without infiltration of the base of the tongue or anterior floor of the mouth. In frozen section diagnostics, the tumor appears to be removed in sano on all sides. Only in the area of the lateral floor of the mouth, towards the depth, are the in sano conditions scarce. For this reason, a completely covering resection was carried out later, which led to definitive histology. In the meantime, endoscopic PEG placement was also performed. This involved insertion with the gastroscope under laryngoscopic control. Easy to see through to the stomach. Here, with good diaphanoscopy, problem-free puncture of the stomach. Subsequent placement of the PEG tube using the usual thread pull-through method. Repositioning of the patient and turning to the neck dissection on the right side. Submandibular extended incision. Dissection of skin and subcutaneous tissue. Dissection of the platysma. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digastric muscle. Clearing out the anterior neck preparation while carefully protecting the facial vein, superior thyroid artery and hypoglossal nerve. In the area of the jugulo-facial angle, a somewhat coarse change is seen, measuring approx. 1 cm, here macroscopically unclear conditions, otherwise no abnormalities on sonographic cN0 neck status. Exposure of the accessorius nerve, clearing of the accessorius triangle and completion of level V a with careful protection of the cervical plexus branches. Subsequent mobilization and removal of the submandibular gland, completion of level I b and removal of the right-sided level I a. Separation of the digastric muscle. Enter enorally and create a tunnel measuring 3 transverse fingers. Subsequent careful hemostasis in the neck area. Initially, the external jugular vein and the auricular nerve were also preserved. Due to the cN0 neck status sonographically and the old, multimorbid and extremely obese patient, neck dissection of the opposite side was not performed. Due to the now extensive defect, the indication for defect coverage with a pedicled graft from the right shoulder was made. Measurement of the defect measuring a total of 10 x 6 cm in the area of the right-sided tongue and the floor of the mouth. Marking of the graft including the acromion. Trimming of the graft. Removal of the graft including the muscle fascia. Lifting of a wide pedicle, including the preclavicular tissue. Exposure of the trapezius muscle. Exposure of the clavicle and successive development of the pedicle by tunneling cervically. Due to the adipose conditions, tension-free graft insertion is only possible up to the level of the anterior floor of the mouth while protecting the pedicled tissue. Extremely well vitalized graft. Suturing of the graft with a good fit, only the tip of the tongue is primarily adapted in order to avoid creating increased tension here. Subsequently, intact conditions on all sides. In the shoulder area, subcutaneous mobilization and strong, multi-layer wound closure after insertion of two 10 Redon drains. Subsequent insertion of a 10 Redon drain in the neck area and careful, two-layer wound closure here too. Finally, due to the adipose conditions and increasing swelling, a protective tracheostomy was performed. To do this, make a horizontal incision at the level of the cricoid cartilage. Cut through skin and subcutaneous tissue. Exposure and transection of the infrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Insertion between the 2nd and 3rd tracheal ring, creation of a visor tracheotomy and suturing of the tracheostoma in a typical manner. Subsequent problem-free reintubation to a size 8 low-cuff cannula, which is suture-fixed. Conclusion: Intraoperative R0 resected cT2 cN0 tongue margin carcinoma on the right. If the graft heals properly, a diet can be started from the 7th postoperative day. Due to the patient's age and obesity, recovery of swallowing function may be delayed. \ No newline at end of file diff --git a/545/InvasionFront_CD3_block15_x1_y12_patient545_0.json b/545/InvasionFront_CD3_block15_x1_y12_patient545_0.json new file mode 100644 index 0000000000000000000000000000000000000000..152d31fac972db0b466798a7b0dfe659ede4c026 --- /dev/null +++ b/545/InvasionFront_CD3_block15_x1_y12_patient545_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6871.4, + "Centroid Y µm": 40128.8, + "Num Detections": 10197, + "Num Negative": 9518, + "Num Positive": 679, + "Positive %": 6.659, + "Num Positive per mm^2": 530.65 + } +} \ No newline at end of file diff --git a/545/InvasionFront_CD3_block15_x2_y12_patient545_1.json b/545/InvasionFront_CD3_block15_x2_y12_patient545_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1663c5d69a01ef9663de94ac3112ce8b4bc6afe8 --- /dev/null +++ b/545/InvasionFront_CD3_block15_x2_y12_patient545_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9520.0, + "Centroid Y µm": 39978.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/545/InvasionFront_CD8_block15_x1_y12_patient545_0.json b/545/InvasionFront_CD8_block15_x1_y12_patient545_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4631a90c4c78430c3a5b77197a4b7086896e7de2 --- /dev/null +++ b/545/InvasionFront_CD8_block15_x1_y12_patient545_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4577.1, + "Centroid Y µm": 29365.0, + "Num Detections": 13134, + "Num Negative": 12709, + "Num Positive": 425, + "Positive %": 3.236, + "Num Positive per mm^2": 199.29 + } +} \ No newline at end of file diff --git a/545/InvasionFront_CD8_block15_x2_y12_patient545_1.json b/545/InvasionFront_CD8_block15_x2_y12_patient545_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aef1cf82edeb2b0469580318b00c8bd17cf296ef --- /dev/null +++ b/545/InvasionFront_CD8_block15_x2_y12_patient545_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7093.3, + "Centroid Y µm": 29311.6, + "Num Detections": 14958, + "Num Negative": 13433, + "Num Positive": 1525, + "Positive %": 10.2, + "Num Positive per mm^2": 737.63 + } +} \ No newline at end of file diff --git a/545/TumorCenter_CD3_block15_x1_y12_patient545_0.json b/545/TumorCenter_CD3_block15_x1_y12_patient545_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9ecb9ae91bf4534649c063c27efad4d8fe874d06 --- /dev/null +++ b/545/TumorCenter_CD3_block15_x1_y12_patient545_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 32907.6, + "Num Detections": 20470, + "Num Negative": 16712, + "Num Positive": 3758, + "Positive %": 18.36, + "Num Positive per mm^2": 1593.0 + } +} \ No newline at end of file diff --git a/545/TumorCenter_CD3_block15_x2_y12_patient545_1.json b/545/TumorCenter_CD3_block15_x2_y12_patient545_1.json new file mode 100644 index 0000000000000000000000000000000000000000..91338543904e97fb55f0391a1e8db9559704ffcc --- /dev/null +++ b/545/TumorCenter_CD3_block15_x2_y12_patient545_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 33082.5, + "Num Detections": 16024, + "Num Negative": 13199, + "Num Positive": 2825, + "Positive %": 17.63, + "Num Positive per mm^2": 1293.7 + } +} \ No newline at end of file diff --git a/545/TumorCenter_CD8_block15_x1_y12_patient545_0.json b/545/TumorCenter_CD8_block15_x1_y12_patient545_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fea5642b3d6c395f99bfe516379668ff0325a470 --- /dev/null +++ b/545/TumorCenter_CD8_block15_x1_y12_patient545_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6446.6, + "Centroid Y µm": 29484.4, + "Num Detections": 19900, + "Num Negative": 15753, + "Num Positive": 4147, + "Positive %": 20.84, + "Num Positive per mm^2": 1746.3 + } +} \ No newline at end of file diff --git a/545/TumorCenter_CD8_block15_x2_y12_patient545_1.json b/545/TumorCenter_CD8_block15_x2_y12_patient545_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ceb738ca2c2c9c45df6821d6e97e4ffd667de779 --- /dev/null +++ b/545/TumorCenter_CD8_block15_x2_y12_patient545_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8820.3, + "Centroid Y µm": 29659.3, + "Num Detections": 16643, + "Num Negative": 14690, + "Num Positive": 1953, + "Positive %": 11.73, + "Num Positive per mm^2": 882.03 + } +} \ No newline at end of file diff --git a/545/history_text.txt b/545/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c61a0a00ef583c3fe6dd36053fc297b5b8db246 --- /dev/null +++ b/545/history_text.txt @@ -0,0 +1 @@ +Patient with a histologically confirmed squamous cell carcinoma of the right posterior border of the tongue for diagnostic panendoscopy and transoral tumor resection. The procedure had already been discussed with the patient preoperatively. \ No newline at end of file diff --git a/545/icd_codes.txt b/545/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c00c83ca628de7d58d64b9fdfa25b6249bf73ae --- /dev/null +++ b/545/icd_codes.txt @@ -0,0 +1 @@ +Plattenepithelkarzinom Zungenrand[C02.1 R] \ No newline at end of file diff --git a/545/ops_codes.txt b/545/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb56eddabb413c28813ce8773b510b6d4b205216 --- /dev/null +++ b/545/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Zungentumorexzision[5-250.2 ] \ No newline at end of file diff --git a/545/patient_clinical_data.json b/545/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c26021a4dc713d34cbfa74481528e77e9911fa26 --- /dev/null +++ b/545/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 76, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/545/patient_pathological_data.json b/545/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..181aefc785664a74a26d64d50da40dc8f76ddc4f --- /dev/null +++ b/545/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "545", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.5 +} \ No newline at end of file diff --git a/545/surgery_description.txt b/545/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8fc98b30d2a2db66db58e75a2d684d64b3fc1148 --- /dev/null +++ b/545/surgery_description.txt @@ -0,0 +1 @@ +Zungentumorexzision, Panendo diff --git a/545/surgery_report.txt b/545/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..50200f2cab04845c4d60027c4b4958804b2ff703 --- /dev/null +++ b/545/surgery_report.txt @@ -0,0 +1 @@ +Initially induction of anesthesia and tracheoscopy, inspection of the trachea up to the carina revealed normal mucosal conditions. Followed by transnasal endotracheal intubation. Positioning of the patient by the surgeon. A flexible esophagoscopy is performed using an endoscope, which is carefully advanced to the stomach under visualization. In the area of the stomach up to the pylorus, conditions are unremarkable. Inversion of the endoscope reveals normal findings in the area of the esophago-gastric junction. The endoscope is then withdrawn and a rigid laryngo- and pharyngoscopy is performed using a Kleinsasser tube. The glottis, subglottis and esophagus are unremarkable. The piriform sinuses on both sides, the posterior wall of the hypopharynx and the postcricoid region were unremarkable. The posterior wall of the oropharynx and the lateral walls were unremarkable. The base of the tongue was unremarkable on endoscopy and palpation. Subsequently, two self-retaining retractors were placed in the oral cavity, a rein suture was placed and the oral cavity was inspected. A maximum 2 cm exophytic mass without significant deep infiltration was found. During palpation of the left posterior border of the tongue, the incision was marked with a large safety margin using an electric needle. Successive resection of the mass, which is sent in for final histology with a suture marker. Hemostasis by means of bipolar coagulation. Repeated inspection. Completion of the procedure without complications. \ No newline at end of file diff --git a/546/InvasionFront_CD3_block22_x5_y4_patient546_0.json b/546/InvasionFront_CD3_block22_x5_y4_patient546_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5e0f7935a7797aa7e1aa86dd2d0286069352f636 --- /dev/null +++ b/546/InvasionFront_CD3_block22_x5_y4_patient546_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17190.9, + "Centroid Y µm": 21563.6, + "Num Detections": 17211, + "Num Negative": 16555, + "Num Positive": 656, + "Positive %": 3.812, + "Num Positive per mm^2": 323.76 + } +} \ No newline at end of file diff --git a/546/InvasionFront_CD3_block22_x6_y4_patient546_1.json b/546/InvasionFront_CD3_block22_x6_y4_patient546_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e775bb79c9801d0a751c99053ac94ed680a5216 --- /dev/null +++ b/546/InvasionFront_CD3_block22_x6_y4_patient546_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19789.5, + "Centroid Y µm": 21613.6, + "Num Detections": 16731, + "Num Negative": 15511, + "Num Positive": 1220, + "Positive %": 7.292, + "Num Positive per mm^2": 587.37 + } +} \ No newline at end of file diff --git a/546/InvasionFront_CD8_block22_x5_y4_patient546_0.json b/546/InvasionFront_CD8_block22_x5_y4_patient546_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b086846d1f4db93a64ccc86f7adb93fe89dd727 --- /dev/null +++ b/546/InvasionFront_CD8_block22_x5_y4_patient546_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 9919.7, + "Num Detections": 15597, + "Num Negative": 15394, + "Num Positive": 203, + "Positive %": 1.302, + "Num Positive per mm^2": 104.25 + } +} \ No newline at end of file diff --git a/546/InvasionFront_CD8_block22_x6_y4_patient546_1.json b/546/InvasionFront_CD8_block22_x6_y4_patient546_1.json new file mode 100644 index 0000000000000000000000000000000000000000..990ee4a0a24ce8e607abc428e78c5a037f58ccfb --- /dev/null +++ b/546/InvasionFront_CD8_block22_x6_y4_patient546_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21488.6, + "Centroid Y µm": 9744.8, + "Num Detections": 12745, + "Num Negative": 12028, + "Num Positive": 717, + "Positive %": 5.626, + "Num Positive per mm^2": 398.28 + } +} \ No newline at end of file diff --git a/546/TumorCenter_CD3_block22_x5_y4_patient546_0.json b/546/TumorCenter_CD3_block22_x5_y4_patient546_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d341098ec1cb48f5e7aa57b07999d4204292bbc9 --- /dev/null +++ b/546/TumorCenter_CD3_block22_x5_y4_patient546_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16816.1, + "Centroid Y µm": 10944.2, + "Num Detections": 8853, + "Num Negative": 8795, + "Num Positive": 58, + "Positive %": 0.6551, + "Num Positive per mm^2": 30.72 + } +} \ No newline at end of file diff --git a/546/TumorCenter_CD3_block22_x6_y4_patient546_1.json b/546/TumorCenter_CD3_block22_x6_y4_patient546_1.json new file mode 100644 index 0000000000000000000000000000000000000000..09c807131878aad98fb247c0288136561b576808 --- /dev/null +++ b/546/TumorCenter_CD3_block22_x6_y4_patient546_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19214.8, + "Centroid Y µm": 10894.2, + "Num Detections": 16262, + "Num Negative": 15209, + "Num Positive": 1053, + "Positive %": 6.475, + "Num Positive per mm^2": 537.47 + } +} \ No newline at end of file diff --git a/546/TumorCenter_CD8_block22_x5_y4_patient546_0.json b/546/TumorCenter_CD8_block22_x5_y4_patient546_0.json new file mode 100644 index 0000000000000000000000000000000000000000..712cc3cb91b8900982d489b7b5b6ad7df7f697d5 --- /dev/null +++ b/546/TumorCenter_CD8_block22_x5_y4_patient546_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19114.9, + "Centroid Y µm": 19989.4, + "Num Detections": 12667, + "Num Negative": 12584, + "Num Positive": 83, + "Positive %": 0.6552, + "Num Positive per mm^2": 42.7 + } +} \ No newline at end of file diff --git a/546/TumorCenter_CD8_block22_x6_y4_patient546_1.json b/546/TumorCenter_CD8_block22_x6_y4_patient546_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2fd72869bc868dc7bc0a31c63675e2c11ffb8e37 --- /dev/null +++ b/546/TumorCenter_CD8_block22_x6_y4_patient546_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21538.6, + "Centroid Y µm": 19964.4, + "Num Detections": 14439, + "Num Negative": 13261, + "Num Positive": 1178, + "Positive %": 8.158, + "Num Positive per mm^2": 592.52 + } +} \ No newline at end of file diff --git a/546/history_text.txt b/546/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/546/icd_codes.txt b/546/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10623317f12e2cf8eb61e998e27f4b464b164dc5 --- /dev/null +++ b/546/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] \ No newline at end of file diff --git a/546/ops_codes.txt b/546/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..57e31e7cb78df138615d610dc27f3678193a327b --- /dev/null +++ b/546/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/546/patient_clinical_data.json b/546/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..41a87f368592e617fad6a1d1b011c92a2722f79f --- /dev/null +++ b/546/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 43, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/546/patient_pathological_data.json b/546/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..745999c24a6971119582f1667ff2f21610533950 --- /dev/null +++ b/546/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "546", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 38, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/546/surgery_description.txt b/546/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..971b356feb177e5a43bbb5c8fcec30966e6433c9 --- /dev/null +++ b/546/surgery_description.txt @@ -0,0 +1 @@ +Laryngektomie mit Teilpharyngektomie, selektive Neck dissection, Provox diff --git a/546/surgery_report.txt b/546/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..bdc1e73145f366ce5a9d4f7701c4b68f65cd88c2 --- /dev/null +++ b/546/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first diagnostic panendoscopy. This shows the large tumor of the left piriform sinus with transition to the laryngeal skeleton and the postcricoid region. Removal of the instruments while protecting the edentulous maxilla. Followed by sterile washing and draping. First perform the tracheotomy through and between the 2nd and 3rd tracheal clasps. Then draw in and incise the apron flap, which is folded upwards. Careful dissection in the area of the left cervical vascular nerve sheath in the case of left carotid disobliteration. Then skeletonize the vascular nerve sheath on the right side with exposure of the hypoglossal nerve and release of the hyoid bone. Subsequent removal of the attachment of the constrictor pharyngis muscle to the lateral thyroid cartilage and extensive release of the piriform sinus on the right. Dissection of the thyroid lobe after cutting through the straight neck muscles. This mobilizes and sufficiently develops the larynx on the right side. Then transition to the opposite side. A similar procedure is performed here, whereby the common carotid artery is first accessed caudally in the area of the scar plate and dissected upwards. Here too, as on the opposite side, the superior thyroid artery can be dissected free for a possible microvascular anastomosis. Subsequent cranial placement of the hyoid bone. Dissection onto the epithelium of the epiglottis and disluxation of the epiglottis. Incision of the hypopharynx. Then the exophytically growing tumor is seen, which is successively released while leaving out the right piriform sinus. The right piriform sinus is naturally included and the two incisions are joined caudally at the cricoid plate. The larynx is then set down on the cricoid and a caudally pedicled mucosal flap is prepared for the Herrmann chimney. The larynx can now be completely removed together with the tumor. On macroscopic observation, all tumor margins are sufficiently distant from the tumor. Nevertheless, marginal incisions are made circularly from the pharyngeal defect. A questionable infiltration with a CIS is seen in the area of the upper right hypopharynx, which was furthest away from the tumor. A resection is therefore performed here. All other marginal areas are free of carcinoma and dysplasia on frozen section histology. Now insertion of a provox prosthesis in the usual manner. Myotomy of the constrictor pharyngis muscle. Subsequent closure of the pharyngeal defect, which is sufficiently wide due to the still existing right piriform sinus, with a first layer of continuous T-shaped Conley suture. The second layer contains the overlying tissue using a single-button technique. Suturing of the mucosal flap to cover the Herrmann chimney. This is followed by bilateral selective neck dissection of regions II-V while preserving all non-lymphatic structures. Insertion of a Redon drain on both sides. Folding back of the apron flap, multi-layer wound closure and completion of the mucocutaneous anastomosis in the area of the tracheostoma. Finally, sterile wound dressing and reintubation of the patient to a 3-bore cannula. End of the operation, transfer of the patient to anesthesia. Conclusion: Total laryngectomy with partial pharyngectomy on the left side for cT4 piriform sinus carcinoma. Selective neck dissection of regions II-V on both sides. Primary voice rehabilitation with a Provox Vega voice prosthesis 8 mm. Installation of a Herrmann chimney. \ No newline at end of file diff --git a/547/InvasionFront_CD3_block7_x1_y11_patient547_0.json b/547/InvasionFront_CD3_block7_x1_y11_patient547_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7f3ac982cd22da2861de2628d874184240e05969 --- /dev/null +++ b/547/InvasionFront_CD3_block7_x1_y11_patient547_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4247.8, + "Centroid Y µm": 27010.7, + "Num Detections": 20105, + "Num Negative": 19262, + "Num Positive": 843, + "Positive %": 4.193, + "Num Positive per mm^2": 337.61 + } +} \ No newline at end of file diff --git a/547/InvasionFront_CD3_block7_x2_y11_patient547_1.json b/547/InvasionFront_CD3_block7_x2_y11_patient547_1.json new file mode 100644 index 0000000000000000000000000000000000000000..19c40dd60b9edf375c429c5cd8cc4e1720944a18 --- /dev/null +++ b/547/InvasionFront_CD3_block7_x2_y11_patient547_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6846.4, + "Centroid Y µm": 26910.8, + "Num Detections": 21239, + "Num Negative": 19787, + "Num Positive": 1452, + "Positive %": 6.836, + "Num Positive per mm^2": 590.27 + } +} \ No newline at end of file diff --git a/547/InvasionFront_CD8_block7_x1_y11_patient547_0.json b/547/InvasionFront_CD8_block7_x1_y11_patient547_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e38d4bba58b20517ce8b8272ab79eead228e8672 --- /dev/null +++ b/547/InvasionFront_CD8_block7_x1_y11_patient547_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3698.0, + "Centroid Y µm": 27160.6, + "Num Detections": 15998, + "Num Negative": 15814, + "Num Positive": 184, + "Positive %": 1.15, + "Num Positive per mm^2": 79.57 + } +} \ No newline at end of file diff --git a/547/InvasionFront_CD8_block7_x2_y11_patient547_1.json b/547/InvasionFront_CD8_block7_x2_y11_patient547_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0d1d804ad7e25d8760e50974e37b8e2d7f382262 --- /dev/null +++ b/547/InvasionFront_CD8_block7_x2_y11_patient547_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 27235.6, + "Num Detections": 20215, + "Num Negative": 19176, + "Num Positive": 1039, + "Positive %": 5.14, + "Num Positive per mm^2": 429.68 + } +} \ No newline at end of file diff --git a/547/TumorCenter_CD3_block7_x1_y11_patient547_0.json b/547/TumorCenter_CD3_block7_x1_y11_patient547_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a22eda493e3b224468b7bb10854632bd40e27fd8 --- /dev/null +++ b/547/TumorCenter_CD3_block7_x1_y11_patient547_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3398.2, + "Centroid Y µm": 27885.2, + "Num Detections": 16320, + "Num Negative": 15279, + "Num Positive": 1041, + "Positive %": 6.379, + "Num Positive per mm^2": 444.23 + } +} \ No newline at end of file diff --git a/547/TumorCenter_CD3_block7_x2_y11_patient547_1.json b/547/TumorCenter_CD3_block7_x2_y11_patient547_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e1f8777a1689b4e53a04d41f9d459dc5a6b8e9e8 --- /dev/null +++ b/547/TumorCenter_CD3_block7_x2_y11_patient547_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 27885.2, + "Num Detections": 18768, + "Num Negative": 18140, + "Num Positive": 628, + "Positive %": 3.346, + "Num Positive per mm^2": 255.96 + } +} \ No newline at end of file diff --git a/547/TumorCenter_CD8_block7_x1_y11_patient547_0.json b/547/TumorCenter_CD8_block7_x1_y11_patient547_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9dae5580df53014b35a2c07176f1d4d60a10abdb --- /dev/null +++ b/547/TumorCenter_CD8_block7_x1_y11_patient547_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3398.2, + "Centroid Y µm": 27285.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/547/TumorCenter_CD8_block7_x2_y11_patient547_1.json b/547/TumorCenter_CD8_block7_x2_y11_patient547_1.json new file mode 100644 index 0000000000000000000000000000000000000000..064707c7fc2bb65986efce9376ea1292c0ec7caf --- /dev/null +++ b/547/TumorCenter_CD8_block7_x2_y11_patient547_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 27485.4, + "Num Detections": 13982, + "Num Negative": 13834, + "Num Positive": 148, + "Positive %": 1.059, + "Num Positive per mm^2": 93.97 + } +} \ No newline at end of file diff --git a/547/history_text.txt b/547/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2561103b4554a3ca55d24810a4489a39e3ec3b36 --- /dev/null +++ b/547/history_text.txt @@ -0,0 +1 @@ +The patient has a carcinoma of the base of the tongue which infiltrates the lingual epiglottis and extends to the hypopharynx and the pharyngoepiglottic fold. The piriform sinus is tumor-free. Sonographically there is a cN0 neck status. \ No newline at end of file diff --git a/547/icd_codes.txt b/547/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/547/ops_codes.txt b/547/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9184192ade89903dfb6434147072c80ab4f51aba --- /dev/null +++ b/547/ops_codes.txt @@ -0,0 +1 @@ +Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.x1 ] Permanente Tracheotomie[5-312.0 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/547/patient_clinical_data.json b/547/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7e53e345ed927cf5fb1a4441d579bf1f766d94eb --- /dev/null +++ b/547/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/547/patient_pathological_data.json b/547/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3c728e1df43d4e7a0da87b0edab220bb73c76a18 --- /dev/null +++ b/547/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "547", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 50, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/547/surgery_description.txt b/547/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb5ddd694457a0281f9820e1e4221f7da4aa1b19 --- /dev/null +++ b/547/surgery_description.txt @@ -0,0 +1 @@ +Transorale roboterassistierte Resektion diff --git a/547/surgery_report.txt b/547/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1f8d1f0547c4c8b166fc4690c7c2af3ae92eb034 --- /dev/null +++ b/547/surgery_report.txt @@ -0,0 +1 @@ +First confirm the findings described above. Then placement of the LARS retractor and docking of the da Vinci robot. This provides a good overview of the tumor. The main tumor mass is located in the vallecula of the left side. The epiglottis appears somewhat infiltrated up to the midline. However, the midline is not crossed. The resection is then performed from the base of the tongue, cranially to caudally. The resection reaches the hyoid bone at the front. The epiglottis is bisected in the middle. Due to the extent of the tumor and for a better overview, the upper part of the tumor must first be removed. The resection is then continued. During hemi-epiglottectomy, the tumor is found to have grown supraglottically and endolaryngeally. The resection is therefore performed up to the supraglottis at the level of the pocket crease on the left side. Dorsally and laterally, the resection reaches the pharyngoepiglottic fold, which can be completely resected. The left ary remains intact. The tumor can then be completely removed. Representative samples are taken from the margins of the cranial and lateral resection area. Likewise, marginal samples are taken from the epiglottic margin, the supraglottic margin and the caudal margin at the base of the tongue. All marginal samples are examined intraoperatively as a frozen section and found to be tumor-free. During resection of the tumor, venous bleeding is seen in the area of the base of the tongue. This bleeding can be stopped using several vascular clips. Repeated careful hemostasis after taking a marginal sample. Then dry wound conditions. Due to the extent of the tumor and the resection area, the decision is made to perform a protective tracheostomy. Removal of all instruments and the blocker and undocking of the da Vinci system. Repositioning of the patient for the tracheostomy. Injection of local anesthetic with adrenaline in front of the trachea. Subsequent transverse incision and layered preparation in depth. Exposure of the pretracheal neck vessels and veins. These are undermined and ligated. Exposure of the prelaryngeal and infrahyoid musculature. Finding the midline. Dissection of the midline and separation of the musculature. Exposure of the thyroid isthmus. This is then undermined and cut on both sides after ligation. Then expose the anterior surface of the trachea. Entering the trachea between the second and third cartilage clasp. Preparation of a Björk flap. Circular suturing of the tracheostoma and epithelialization. Then insertion of an 8 mm tracheostomy tube. Completion of the procedure after bandaging. The patient is transferred to the ENT intensive care unit for monitoring. After checking the swallowing function, the patient may have to be fed nasogastrically with a feeding tube for the next few days in the event of aspiration. The patient should always remain under intensive medical supervision over the weekend. \ No newline at end of file diff --git a/548/InvasionFront_CD3_block3_x1_y11_patient548_0.json b/548/InvasionFront_CD3_block3_x1_y11_patient548_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f316c2b0d30cc6760a1ecb760b5d4dc51fe641f2 --- /dev/null +++ b/548/InvasionFront_CD3_block3_x1_y11_patient548_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3584.5, + "Centroid Y µm": 32690.1, + "Num Detections": 9144, + "Num Negative": 8677, + "Num Positive": 467, + "Positive %": 5.107, + "Num Positive per mm^2": 420.62 + } +} \ No newline at end of file diff --git a/548/InvasionFront_CD3_block3_x2_y11_patient548_1.json b/548/InvasionFront_CD3_block3_x2_y11_patient548_1.json new file mode 100644 index 0000000000000000000000000000000000000000..631e8fb9a1a492bc634701550360bed6cf1d3782 --- /dev/null +++ b/548/InvasionFront_CD3_block3_x2_y11_patient548_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6142.4, + "Centroid Y µm": 33171.8, + "Num Detections": 19645, + "Num Negative": 18302, + "Num Positive": 1343, + "Positive %": 6.836, + "Num Positive per mm^2": 589.22 + } +} \ No newline at end of file diff --git a/548/InvasionFront_CD8_block3_x1_y9_patient548_0.json b/548/InvasionFront_CD8_block3_x1_y9_patient548_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9e9051b0a74d5224bd3c98cd3c5858b7c53c048b --- /dev/null +++ b/548/InvasionFront_CD8_block3_x1_y9_patient548_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5009.4, + "Centroid Y µm": 22163.3, + "Num Detections": 17405, + "Num Negative": 11256, + "Num Positive": 6149, + "Positive %": 35.33, + "Num Positive per mm^2": 2622.4 + } +} \ No newline at end of file diff --git a/548/InvasionFront_CD8_block3_x2_y9_patient548_1.json b/548/InvasionFront_CD8_block3_x2_y9_patient548_1.json new file mode 100644 index 0000000000000000000000000000000000000000..11492ea4c18075bc2c3a9e494212d8441c409963 --- /dev/null +++ b/548/InvasionFront_CD8_block3_x2_y9_patient548_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7720.9, + "Centroid Y µm": 22163.3, + "Num Detections": 18490, + "Num Negative": 11804, + "Num Positive": 6686, + "Positive %": 36.16, + "Num Positive per mm^2": 2745.1 + } +} \ No newline at end of file diff --git a/548/TumorCenter_CD3_block3_x1_y9_patient548_0.json b/548/TumorCenter_CD3_block3_x1_y9_patient548_0.json new file mode 100644 index 0000000000000000000000000000000000000000..61997a07ae2088ed90a8aad42340b5e209016462 --- /dev/null +++ b/548/TumorCenter_CD3_block3_x1_y9_patient548_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3423.2, + "Centroid Y µm": 28410.0, + "Num Detections": 13767, + "Num Negative": 10163, + "Num Positive": 3604, + "Positive %": 26.18, + "Num Positive per mm^2": 1869.0 + } +} \ No newline at end of file diff --git a/548/TumorCenter_CD3_block3_x2_y9_patient548_1.json b/548/TumorCenter_CD3_block3_x2_y9_patient548_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ada547bf54ec07a8bff543be9f752f99beb409ed --- /dev/null +++ b/548/TumorCenter_CD3_block3_x2_y9_patient548_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 28484.9, + "Num Detections": 14775, + "Num Negative": 11282, + "Num Positive": 3493, + "Positive %": 23.64, + "Num Positive per mm^2": 1693.3 + } +} \ No newline at end of file diff --git a/548/TumorCenter_CD8_block3_x1_y9_patient548_0.json b/548/TumorCenter_CD8_block3_x1_y9_patient548_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d63dcc0a1aae4fbbb17ace924322c24e595e976 --- /dev/null +++ b/548/TumorCenter_CD8_block3_x1_y9_patient548_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3947.9, + "Centroid Y µm": 22812.9, + "Num Detections": 16035, + "Num Negative": 11404, + "Num Positive": 4631, + "Positive %": 28.88, + "Num Positive per mm^2": 2113.1 + } +} \ No newline at end of file diff --git a/548/TumorCenter_CD8_block3_x2_y9_patient548_1.json b/548/TumorCenter_CD8_block3_x2_y9_patient548_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8708e4f54a399ef7547eb5513d5c31e05b302596 --- /dev/null +++ b/548/TumorCenter_CD8_block3_x2_y9_patient548_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 23062.8, + "Num Detections": 16029, + "Num Negative": 12127, + "Num Positive": 3902, + "Positive %": 24.34, + "Num Positive per mm^2": 1779.9 + } +} \ No newline at end of file diff --git a/548/history_text.txt b/548/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b90be89ccf67501bd3385cbb12040c193e6feeaf --- /dev/null +++ b/548/history_text.txt @@ -0,0 +1 @@ +The patient has been suffering from dysphagia and irritable cough for 5 months. The panendoscopy and sampling performed <2016> revealed a T2 hypopharyngeal carcinoma, which protrudes very close to the cervical vascular sheath laterally. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/548/icd_codes.txt b/548/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e047c162192d3ed091553df2cb3472f6813ec410 --- /dev/null +++ b/548/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] Halslymphknotenmetastasen[C77.0 L] \ No newline at end of file diff --git a/548/ops_codes.txt b/548/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d6690bc846f85e141057848afba6ac4f5447ab86 --- /dev/null +++ b/548/ops_codes.txt @@ -0,0 +1 @@ +Transplantation sonstiges Transplantat mit mikrovaskulärer Anastomosierung Sonstige[5-858.9x L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 Permanente Tracheotomie[5-312.0 ] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Entnahme freier Radialis-Lappen[5-858.23 L] Wechsel eines vaskulären Implantates[5-394.3 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] \ No newline at end of file diff --git a/548/patient_clinical_data.json b/548/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ebc6a61f4b24bd67178d5243ab8dfb4fd064920d --- /dev/null +++ b/548/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 49, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/548/patient_pathological_data.json b/548/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b4c46cfd64b258e440638117a075ef0e1ae74d85 --- /dev/null +++ b/548/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "548", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/548/surgery_description.txt b/548/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..766847db459d8beb5d7ecc55c69a013b77ecd987 --- /dev/null +++ b/548/surgery_description.txt @@ -0,0 +1 @@ +Resektion, Neck dissection sowie Tracheotomie diff --git a/548/surgery_report.txt b/548/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..67b33b97d7d222e8e2b6700ee7f1bfe211ea160d --- /dev/null +++ b/548/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and transnasal intubation by the anesthesia colleagues. Entry with the small bore tube and inspection of the hypopharynx and larynx. An exophytic tumor can be seen on the left side wall of the hypopharynx, extending to the entrance of the piriform sinus. The postcricoid region, the esophageal entrance and the tip of the left piriform sinus are free. The entire glottis is also free. Preoperatively, it was not possible to see the mobility of the left vocal fold due to tumor displacement. However, it is now apparent that the left arytenoid cartilage is not affected by the tumor. Due to the extension in the direction of the cervical sheath and the difficulty of adjustment, the decision was made to resect the tumor transcervically and, if necessary, cover it with a transplant. Injection of Ultracaine, then sterile washing and covering. Creation of an apron flap, then start with the neck dissection on the left side. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle, exposure of the submandibular gland. Level II shows a large conglomerate of lymph nodes which lies on the internal jugular vein. The internal jugular vein can be freed from the conglomerate. The facial vein is infiltrated and must be removed. Expose the hypoglossal nerve and the accessorius and release the remaining neck preparation level II a to V a while sparing the plexus branches. Now release the hyoid bone on the left side and remove the left half of the hyoid bone to gain direct access to the pharynx. Bimanual palpation from the transoral side and identification of the tumor. Release of the piriform sinus below the thyroid cartilage. Entering the pharynx above the tumor on the pharyngeal side wall. Inspection of the tumor. Now remove and cut around the tumor with a safety margin of 2 cm. The tumor can be retrieved enbloc and is placed completely on cork for frozen section. All edges as well as the wound bed are in sano in the frozen section. Due to the large defect, primary closure of the pharynx is no longer possible. Therefore, measurement of the defect and decision to cover the defect using a radialis graft. Start of elevation of the radialis graft by . Marking of the graft 15 x 10 cm. Cutting around the skin island and opening the skin on the forearm. Exposure of the brachioradialis muscle. Exposure of the cephalic vein. takes over the elevation of the radialis graft, dissects further and exposes the superficial ramus of the radial nerve, lifts the graft away from the tendon bed and first exposes the radial artery. There is good perfusion of the hand, which can also be verified by pulse oximetry. Further release of the graft and preparation of the vascular pedicle in the usual manner. The radial artery can be removed in the crook of the elbow, including the venous confluence with the possibility of venous connection of a superficial and a deep vein. Then usual closure of the forearm with split skin from the right thigh by and . The full-thickness skin was removed by and . Parallel to the elevation of the radialis graft, the neck dissection is performed on the right side by . After the neck dissection on the left side, the patient is repositioned for the neck dissection on the right side. Incision already made as part of the previous dissection incisions. Locate the sternocleidomastoid muscle and dissect its anterior border in depth. Exposure of the anterior border up to level IV and up to level II while exposing and protecting the accessorius nerve. Exposure of the posterior abdomen of the digastric muscle. Dissection along the digastric muscle and exposure of the submandibular gland. Removal of the capsule in the caudal region. Exposure of the surface of the omohyoid muscle up to its cranial and caudal edge. Exposure of the cervical vascular sheath. Dissection of the same and removal of the soft tissue from medial to lateral and successive development of the neck preparation. Protection of the vagus nerve, the jugular vein and the common carotid artery. Exposure of the bifurcation. Dissection of external carotid artery branches for subsequent anastomosis. Successive development of the neck preparation and hemorrhage-free removal. Protection of the branches of the cervical plexus, which also represents the maximum posterior penetration depth of the neck dissection. At the posterior edge of the sternocleidomastoid, further dissection in depth and exposure of level V, where the neck preparation is also removed here. Neck dissection of the caudal level I b, II, III, IV and proportionally V of the right side. Irrigation with hydrogen peroxide and Ringer's solution. Finally, placement of a Redon drain. Repositioning of the patient for tracheostomy. Entry through the previously made apron incision and preparation of the cricoid cartilage. Exposure of the isthmus of the thyroid gland. Dissection and coagulation of the thyroid and subsequent transection. Individual craniocaudal veins are ligated. Exposure of the anterior wall of the trachea. Entering the trachea. Placement of tracheostomy sutures and, in the further course of the operation, finally reintubation with final placement of an 8-gauge tracheostomy tube. Suturing of the transplant by . Multiple sutures must be submitted for this. The upper horn of the thyroid cartilage is resected to gain further access to the defect. First, an attempt is made to preserve the superior laryngeal nerve on the left side, but due to the thickness of the graft it is not possible to insert the entire graft between the pharynx and the superior laryngeal nerve, so this nerve must unfortunately be severed. Then complete suturing of the graft and positioning of the stalk on the right side. For this purpose, the superior thyroid artery is prepared for the arterial connection and the facial vein with an outlet for the venous connections. First start with the arterial anastomosis. Suture with 8.0 Ethilon. This reveals good pedicle perfusion and good venous return. Preparation of the vein. Unfortunately, the suction cup sucks in the pedicle and the entire arterial anastomosis is torn off. The arteries must therefore be shortened on both sides, prepared anew and anastomosed again. Only then can the two veins be couplers with a size 3.5 coupler. Now position the stem again. Fold back the apron flap. Incision of the tracheostoma and two-layer wound closure. A Redon drain was inserted on the left side and a flap on the right side. Continue antibiotics for at least 24 hours. Doppler control according to the usual procedure, a suture marker was placed on the neck and the flap can also be examined transorally. After receiving the histology, the patient is presented at the tumor conference to plan adjuvant therapy. \ No newline at end of file diff --git a/549/InvasionFront_CD3_block5_x3_y12_patient549_0.json b/549/InvasionFront_CD3_block5_x3_y12_patient549_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4c9b207ea9a1eaaeae3b91a2461fd3f74052aed8 --- /dev/null +++ b/549/InvasionFront_CD3_block5_x3_y12_patient549_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 30708.7, + "Num Detections": 16525, + "Num Negative": 14009, + "Num Positive": 2516, + "Positive %": 15.23, + "Num Positive per mm^2": 1156.8 + } +} \ No newline at end of file diff --git a/549/InvasionFront_CD3_block5_x4_y12_patient549_1.json b/549/InvasionFront_CD3_block5_x4_y12_patient549_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2807a816c07e735ca3652bc9ba9dcf76638aa53b --- /dev/null +++ b/549/InvasionFront_CD3_block5_x4_y12_patient549_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 30708.7, + "Num Detections": 15352, + "Num Negative": 13066, + "Num Positive": 2286, + "Positive %": 14.89, + "Num Positive per mm^2": 1202.5 + } +} \ No newline at end of file diff --git a/549/InvasionFront_CD8_block5_x3_y10_patient549_0.json b/549/InvasionFront_CD8_block5_x3_y10_patient549_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f5c3c4ffee8ed13824e3e0d4b83cd1c99952bf70 --- /dev/null +++ b/549/InvasionFront_CD8_block5_x3_y10_patient549_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11094.1, + "Centroid Y µm": 24961.8, + "Num Detections": 20337, + "Num Negative": 19311, + "Num Positive": 1026, + "Positive %": 5.045, + "Num Positive per mm^2": 414.69 + } +} \ No newline at end of file diff --git a/549/InvasionFront_CD8_block5_x4_y10_patient549_1.json b/549/InvasionFront_CD8_block5_x4_y10_patient549_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ae09066d14498b32873520f7152eb723e3f35c04 --- /dev/null +++ b/549/InvasionFront_CD8_block5_x4_y10_patient549_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 24936.8, + "Num Detections": 22203, + "Num Negative": 20390, + "Num Positive": 1813, + "Positive %": 8.166, + "Num Positive per mm^2": 749.64 + } +} \ No newline at end of file diff --git a/549/TumorCenter_CD3_block5_x3_y10_patient549_0.json b/549/TumorCenter_CD3_block5_x3_y10_patient549_0.json new file mode 100644 index 0000000000000000000000000000000000000000..88d7c50596a71f05db3c0f34ae9a0ab8362f64d8 --- /dev/null +++ b/549/TumorCenter_CD3_block5_x3_y10_patient549_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 24836.8, + "Num Detections": 21433, + "Num Negative": 18523, + "Num Positive": 2910, + "Positive %": 13.58, + "Num Positive per mm^2": 1176.7 + } +} \ No newline at end of file diff --git a/549/TumorCenter_CD3_block5_x4_y10_patient549_1.json b/549/TumorCenter_CD3_block5_x4_y10_patient549_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fa7764e5b679843f063c60ba068e5ba6bdfc296a --- /dev/null +++ b/549/TumorCenter_CD3_block5_x4_y10_patient549_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 25111.7, + "Num Detections": 20860, + "Num Negative": 18993, + "Num Positive": 1867, + "Positive %": 8.95, + "Num Positive per mm^2": 811.3 + } +} \ No newline at end of file diff --git a/549/TumorCenter_CD8_block5_x3_y10_patient549_0.json b/549/TumorCenter_CD8_block5_x3_y10_patient549_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a404e4751e82bc597d4d9954d8146e2f841138ed --- /dev/null +++ b/549/TumorCenter_CD8_block5_x3_y10_patient549_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10869.2, + "Centroid Y µm": 25136.7, + "Num Detections": 22319, + "Num Negative": 21091, + "Num Positive": 1228, + "Positive %": 5.502, + "Num Positive per mm^2": 493.17 + } +} \ No newline at end of file diff --git a/549/TumorCenter_CD8_block5_x4_y10_patient549_1.json b/549/TumorCenter_CD8_block5_x4_y10_patient549_1.json new file mode 100644 index 0000000000000000000000000000000000000000..27b1bba2ab60434b13f6df69436d5acce14a65f6 --- /dev/null +++ b/549/TumorCenter_CD8_block5_x4_y10_patient549_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 25161.7, + "Num Detections": 19484, + "Num Negative": 18417, + "Num Positive": 1067, + "Positive %": 5.476, + "Num Positive per mm^2": 458.19 + } +} \ No newline at end of file diff --git a/549/history_text.txt b/549/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4ada162a9dc2ae01da2418dc3e2f5a9f3646de66 --- /dev/null +++ b/549/history_text.txt @@ -0,0 +1 @@ +The patient has an externally confirmed p16-negative squamous cell carcinoma of the oropharynx on the right side. Computed tomography cT3 cN0 cM0. There is now an indication for re-panendoscopy and tumor resection. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/549/icd_codes.txt b/549/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adab28f0b88ba31c5bb4895a3d4f3034f2967b3e --- /dev/null +++ b/549/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] \ No newline at end of file diff --git a/549/ops_codes.txt b/549/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..37591fa2695bb907b54b85b4a3d755a734636115 --- /dev/null +++ b/549/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Transorale Tumortonsillektomie[5-281.2 ] Temporäre Tracheotomie[5-311.0 ] Injektion in Haut und Unterhaut zur Lokalanästhesie[8-020.x B] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/549/patient_clinical_data.json b/549/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f4f6857475aa1a2d5df968cd8a51a3a8003658c3 --- /dev/null +++ b/549/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 80, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/549/patient_pathological_data.json b/549/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9a5ad9a1c97caba8104b6ea80dea8929b25371d2 --- /dev/null +++ b/549/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "549", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/549/surgery_description.txt b/549/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9866990c7d456459839bb9fd68daf4a8ce0576f7 --- /dev/null +++ b/549/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion, Tracheostomaanlage, Re-Panendo diff --git a/549/surgery_report.txt b/549/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7795874a2f5b36c7592615ac02a303babe5cc96f --- /dev/null +++ b/549/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesia department. Induction of anesthesia and intubation of the patient. After fixation of the tube, the patient is positioned by the surgeon. Start of esophagogastroscopy. Insertion of the endoscope under visualization and constant air insufflation into the stomach. A typical gastric mucosal relief without irritation can be seen on all sides. After entering in inversion, the findings in the area of the gastroesophageal junction are also unremarkable. After desufflation, slow withdrawal of the endoscope with circular inspection of all esophageal sections. The mucosa is unremarkable on all sides. Remove the flexible endoscope. Insert the mouth guard and enter with the small bore tube. Initial inspection of the endolarynx, hypopharynx and esophageal entrance. This reveals normal conditions on all sides. This is followed by inspection of the oral cavity and the oral vestibule. With the exception of the large tonsillar carcinoma on the right side, the findings were otherwise unremarkable, with no evidence of a synchronous second tumor. Removal of the small drainage tube. Insertion of the McIvor oral spatula while protecting the teeth, lips and tongue. Palpatory exploration of the tonsil region. A transoral resection appears possible both by inspection and palpation. Therefore, first incision in the area of the soft palate laterally at the transition to the hard palate. Successive sharp and blunt dissection along the musculature while maintaining the necessary resection distance to the tumor. The resection is carried out taking a large part of the palatoglossus muscle with it. Laterally, the tumor extends into the parapharyngeal soft tissue. A displacement layer remains between the lateral tumor extensions and the external carotid artery. Initially blunt dissection laterally along the displacement layer caudally. Dorsally, the tumor extends to the posterior pharyngeal wall. Here too, resection is performed while maintaining the necessary safety distance. Caudally, the tumor extends to the base of the tongue. The tumor can be resected in sano both by inspection and palpation with the appropriate safety distance. A marginal sample is taken from the glossotonsillar margin to the base of the tongue and a marginal sample from the right parauvular margin. In the meantime, meticulous hemostasis using bipolar coagulation and insertion of H2O2-soaked compresses. During the frozen section by telephone, high-grade dysplasia is seen in the area of the marginal sample from the glossotonsillar to the base of the tongue. Therefore, an appropriate resection is performed here. Repeated hemostasis using bipolar coagulation. Due to the extent of the resection, especially laterally to just before the branches of the external carotid artery, a layer of Tachosil is now applied in the area of the lateral wound bed. In addition, the remaining muscles are mobilized and adapted to protect the cervical sheath. Adaptation is performed using Vicryl 3-0 RB1 sutures. As part of the adaptive suturing of the musculature, long-distance coagulation of a slightly larger venous vessel and clipping of a smaller artery is also performed. Both vessels are finally covered extensively in front of the adapted muscle layer. Very good aspect at the end of the operation. Due to the extensive resection area, the decision is made intraoperatively to create a protective tracheostoma. Repositioning of the patient and skin spray disinfection. Infiltration anesthesia. Skin wipe disinfection and sterile draping. Initial palpatory identification and color marking of the thyroid incisura and the level of the cricoid cartilage. Mark the planned incision approx. 1 QF below the level of the cricoid cartilage. Sharply cut through the cutis as well as the subcutis. Dissect the prelaryngeal musculature. Separation of the muscle bellies in the area of the linea alba. Exposure of the lower edge of the cricoid cartilage. Insertion of the retractors. Exposure of the thyroid isthmus. Undermining the thyroid isthmus using the Péan clamp. Bipolar coagulation of a relatively tender thyroid isthmus and lateralization of the two thyroid lobes. The anterior tracheal wall is now exposed over a large area. Enter between the 2nd and 3rd tracheal ring. First open the trachea. Creation of a visor incision and subsequent tension-free epithelization of the tracheostoma. Subsequently, easy transfer to an 8-gauge high-volume low-pressure tracheostomy tube. The patient can be ventilated easily and adequately via the tracheostomy tube. Application of the cannula tape. Finally, a nasogastric tube is inserted. This is done via the left nostril so that there is no manipulation in the area of the extensive wound bed. Final consultation with the anesthetist. Removal of the oral spatula and completion of the operation without complications. \ No newline at end of file diff --git a/550/InvasionFront_CD3_block5_x3_y8_patient550_0.json b/550/InvasionFront_CD3_block5_x3_y8_patient550_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b97fb01f638136ff7f409b396adfdf6d77609ac --- /dev/null +++ b/550/InvasionFront_CD3_block5_x3_y8_patient550_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 20464.2, + "Num Detections": 24424, + "Num Negative": 21233, + "Num Positive": 3191, + "Positive %": 13.07, + "Num Positive per mm^2": 1440.4 + } +} \ No newline at end of file diff --git a/550/InvasionFront_CD3_block5_x4_y8_patient550_1.json b/550/InvasionFront_CD3_block5_x4_y8_patient550_1.json new file mode 100644 index 0000000000000000000000000000000000000000..df61e931c932717e025d941f661e662c1fe49991 --- /dev/null +++ b/550/InvasionFront_CD3_block5_x4_y8_patient550_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 20514.1, + "Num Detections": 28949, + "Num Negative": 25674, + "Num Positive": 3275, + "Positive %": 11.31, + "Num Positive per mm^2": 1381.2 + } +} \ No newline at end of file diff --git a/550/InvasionFront_CD8_block5_x3_y6_patient550_0.json b/550/InvasionFront_CD8_block5_x3_y6_patient550_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b78df8a26746f32e93233b2dc0ca88c14a4585b0 --- /dev/null +++ b/550/InvasionFront_CD8_block5_x3_y6_patient550_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 15466.8, + "Num Detections": 16368, + "Num Negative": 12621, + "Num Positive": 3747, + "Positive %": 22.89, + "Num Positive per mm^2": 2473.9 + } +} \ No newline at end of file diff --git a/550/InvasionFront_CD8_block5_x4_y6_patient550_1.json b/550/InvasionFront_CD8_block5_x4_y6_patient550_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a5f917a79a24fddf6dd3d1f25d990020656a5c8e --- /dev/null +++ b/550/InvasionFront_CD8_block5_x4_y6_patient550_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 15117.0, + "Num Detections": 11021, + "Num Negative": 9531, + "Num Positive": 1490, + "Positive %": 13.52, + "Num Positive per mm^2": 1377.1 + } +} \ No newline at end of file diff --git a/550/TumorCenter_CD3_block5_x3_y6_patient550_0.json b/550/TumorCenter_CD3_block5_x3_y6_patient550_0.json new file mode 100644 index 0000000000000000000000000000000000000000..89b0a0d3a679b98658ce96b6a808a7405c740b27 --- /dev/null +++ b/550/TumorCenter_CD3_block5_x3_y6_patient550_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11993.6, + "Centroid Y µm": 14742.2, + "Num Detections": 15069, + "Num Negative": 12818, + "Num Positive": 2251, + "Positive %": 14.94, + "Num Positive per mm^2": 1091.0 + } +} \ No newline at end of file diff --git a/550/TumorCenter_CD3_block5_x4_y6_patient550_1.json b/550/TumorCenter_CD3_block5_x4_y6_patient550_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8bd52a0cda10b66806e8326303e75bc123d82543 --- /dev/null +++ b/550/TumorCenter_CD3_block5_x4_y6_patient550_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14517.3, + "Centroid Y µm": 15167.0, + "Num Detections": 19524, + "Num Negative": 14563, + "Num Positive": 4961, + "Positive %": 25.41, + "Num Positive per mm^2": 2275.0 + } +} \ No newline at end of file diff --git a/550/TumorCenter_CD8_block5_x3_y6_patient550_0.json b/550/TumorCenter_CD8_block5_x3_y6_patient550_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d3ed6b2aa9c246dad9ab1296a7a17aa7426344e7 --- /dev/null +++ b/550/TumorCenter_CD8_block5_x3_y6_patient550_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 14892.1, + "Num Detections": 25205, + "Num Negative": 18427, + "Num Positive": 6778, + "Positive %": 26.89, + "Num Positive per mm^2": 2623.8 + } +} \ No newline at end of file diff --git a/550/TumorCenter_CD8_block5_x4_y6_patient550_1.json b/550/TumorCenter_CD8_block5_x4_y6_patient550_1.json new file mode 100644 index 0000000000000000000000000000000000000000..303265ccab2509f3413ec22a7f5dad00da131f62 --- /dev/null +++ b/550/TumorCenter_CD8_block5_x4_y6_patient550_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 15067.0, + "Num Detections": 24371, + "Num Negative": 18474, + "Num Positive": 5897, + "Positive %": 24.2, + "Num Positive per mm^2": 2312.6 + } +} \ No newline at end of file diff --git a/550/history_text.txt b/550/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..dfc61fe839dd332215d6fb926c56492d455fe273 --- /dev/null +++ b/550/history_text.txt @@ -0,0 +1 @@ +After an initial coarse needle biopsy without meaningful results, a histological diagnosis of a squamous cell carcinoma metastasis, HPV-associated, was made during a panendoscopy without evidence of a primary tumor with lymph node extirpation from level V. At the interdisciplinary tumor conference, after performing PET-CT diagnostics with no evidence of a primary tumor, the decision was made to perform a CUP panendoscopy and neck dissection on the right. No further questions after detailed preoperative discussions. \ No newline at end of file diff --git a/550/icd_codes.txt b/550/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..39a092381de42dd88cae8a9b276c13d16b23a6cd --- /dev/null +++ b/550/icd_codes.txt @@ -0,0 +1 @@ +Halslymphknotenmetastasen[C77.0 R] Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] \ No newline at end of file diff --git a/550/ops_codes.txt b/550/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8e7f4ae2ed41cc4c4e8f72d719924921cfd0b62a --- /dev/null +++ b/550/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Tonsillektomie mit Adenotomie mit Dissektionstechnik[5-282.0 ] Biopsie Oropharynx onA durch Inzision[1-546 ] Biopsie am Nasopharynx durch Inzision[1-548 ] \ No newline at end of file diff --git a/550/patient_clinical_data.json b/550/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..94039e8a53c41a3e99400f5bdf06fcceadf276c2 --- /dev/null +++ b/550/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 62, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 57, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/550/patient_pathological_data.json b/550/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9c86ce9f7985101b21975334a78ec3d2b0382575 --- /dev/null +++ b/550/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "550", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/550/surgery_description.txt b/550/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f8d55f4c3bfa2c902471bf0b9360f9ec8687cca7 --- /dev/null +++ b/550/surgery_description.txt @@ -0,0 +1 @@ +CUP-Panendo, Tonsillektomie, Neck Dissection diff --git a/550/surgery_report.txt b/550/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..15a084748e71fb36987b8d352842ec136e2135f8 --- /dev/null +++ b/550/surgery_report.txt @@ -0,0 +1 @@ +After problem-free intubation by the anesthesia colleagues, repeated pharyngoscopy and laryngoscopy with the Kleinsasser C-tube after insertion of a mouth guard with confirmation of the previous panendoscopy findings without evidence of a primary tumor. Now incisional biopsies of the base of the tongue on the right, middle and left and monopolar coagulation. Hemostasis. Then insertion of the Mc Ivor oral flap and initially tonsillectomy on the left in the typical manner after exposing the tonsil capsule, the upper pole. Using the dissection technique after caudal detachment of the tonsil, which is macroscopically inconspicuous, very small. Separation at the caudal pole with a clear border to the base of the tongue. Hydrogen swab insertion and removal without evidence of bleeding. Identical procedure with analogous findings on the right side. Previously, epipharyngoscopy was performed without evidence of a tumor and nasopharyngeal curettage and insertion and removal of swabs and hemostasis. After completion of the panendoscopy without any problems, head positioning to the left for the neck dissection on the right: After infiltration in the area of the planned skin incision with Ultracaine 2% with Suprarenin additive, skin disinfection/ablation and sterile draping. Marking of the landmarks and the curved neck incision cervically on the right at the front edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. First preservation, then later ligation of the external jugular vein. Preservation and sparing of the auricularis magnus nerve. Dissection of the anterior edge of the muscle in depth and exposure of the accessorius nerve. Caudal exposure of the entire length of the omohyoid muscle, exposure of the belly of the submandibular gland and dissection along the capsule to the posterior digastric venter muscle. Insert the cranial and caudal retractors after dissection of all landmarks. Now first remove the anterior neck preparation down to the level of the superior thyroid artery after preparation on the internal jugular vein from caudal to cranial and mobilization of the neck preparations. Then clearing of the posterior neck preparation, starting at level IIb. Here, the conditions were heavily scarred due to the previous operation after the lymph node removal from level V far cranially. While sparing the accessorius nerve, which was also exposed during the previous operation, remove it down to the level of the scalene muscles. After clearing level IIb, continue resection of the neck preparation from cranial to caudal while sparing and preserving all plexus branches and the cervical nerve. Caudal resection below the level of the omohyoid muscle without evidence of chyle flow. Resection of the neck preparation behind the sternocleidomastoid muscle while sparing the plexus branches. This results in a neck dissection level II to V, with initial lymph node metastasis in level V. Macroscopically, this neck dissection shows enlarged lymph nodes up to approx. 1.5 cm in size, macroscopically also possible metastases, but not clear. Finally, hemostasis and completion of the procedure without complications after insertion and suturing of a Redon drainage and two-layer wound closure. Conclusion: CUP panendoscopy and neck dissection right level II to V in the case of a panendoscopy and lymph node extirpation from level V with histologically confirmed HPV-associated squamous cell carcinoma metastasis. Procedure: Redon ex depending on support, presentation at our tumor conference to discuss the tongue base biopsies, nasopharyngeal biopsy and tonsils on both sides as well as the neck preparation for planning adjuvant radiochemotherapy. Then also planning of a PEG insertion, for which the patient was not informed at the time of this operation. \ No newline at end of file diff --git a/551/InvasionFront_CD3_block11_x1_y6_patient551_0.json b/551/InvasionFront_CD3_block11_x1_y6_patient551_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9ce8b0c4d125632de9e51e3b45ea01c4171c7bb8 --- /dev/null +++ b/551/InvasionFront_CD3_block11_x1_y6_patient551_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3198.3, + "Centroid Y µm": 14792.2, + "Num Detections": 23053, + "Num Negative": 21699, + "Num Positive": 1354, + "Positive %": 5.873, + "Num Positive per mm^2": 510.03 + } +} \ No newline at end of file diff --git a/551/InvasionFront_CD3_block11_x2_y6_patient551_1.json b/551/InvasionFront_CD3_block11_x2_y6_patient551_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8422f1f580a6c3d08c8382ec7149675a2cb0a53a --- /dev/null +++ b/551/InvasionFront_CD3_block11_x2_y6_patient551_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 14692.2, + "Num Detections": 13668, + "Num Negative": 13166, + "Num Positive": 502, + "Positive %": 3.673, + "Num Positive per mm^2": 334.33 + } +} \ No newline at end of file diff --git a/551/InvasionFront_CD8_block11_x1_y6_patient551_0.json b/551/InvasionFront_CD8_block11_x1_y6_patient551_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f0b2c068ff939d215d0119b05f9223962b10665 --- /dev/null +++ b/551/InvasionFront_CD8_block11_x1_y6_patient551_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 25661.4, + "Num Detections": 22683, + "Num Negative": 21698, + "Num Positive": 985, + "Positive %": 4.342, + "Num Positive per mm^2": 388.02 + } +} \ No newline at end of file diff --git a/551/InvasionFront_CD8_block11_x2_y6_patient551_1.json b/551/InvasionFront_CD8_block11_x2_y6_patient551_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b93482f4859b3b7389aafcdbb476109e12796ce7 --- /dev/null +++ b/551/InvasionFront_CD8_block11_x2_y6_patient551_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8950.3, + "Centroid Y µm": 25562.9, + "Num Detections": 6115, + "Num Negative": 6032, + "Num Positive": 83, + "Positive %": 1.357, + "Num Positive per mm^2": 100.53 + } +} \ No newline at end of file diff --git a/551/TumorCenter_CD3_block11_x1_y6_patient551_0.json b/551/TumorCenter_CD3_block11_x1_y6_patient551_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2e087627ef2c64b6be5367546367a68ffdc3932e --- /dev/null +++ b/551/TumorCenter_CD3_block11_x1_y6_patient551_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7065.3, + "Centroid Y µm": 14464.2, + "Num Detections": 14323, + "Num Negative": 13980, + "Num Positive": 343, + "Positive %": 2.395, + "Num Positive per mm^2": 206.66 + } +} \ No newline at end of file diff --git a/551/TumorCenter_CD3_block11_x2_y6_patient551_1.json b/551/TumorCenter_CD3_block11_x2_y6_patient551_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ba10c59f41542e35c8209f105e7af254a2da21b9 --- /dev/null +++ b/551/TumorCenter_CD3_block11_x2_y6_patient551_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9473.9, + "Centroid Y µm": 14576.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/551/TumorCenter_CD8_block11_x1_y6_patient551_0.json b/551/TumorCenter_CD8_block11_x1_y6_patient551_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a3e86de84c6d3e6fcca92db022ae5536d7f7895d --- /dev/null +++ b/551/TumorCenter_CD8_block11_x1_y6_patient551_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4622.6, + "Centroid Y µm": 14567.3, + "Num Detections": 11580, + "Num Negative": 11176, + "Num Positive": 404, + "Positive %": 3.489, + "Num Positive per mm^2": 294.08 + } +} \ No newline at end of file diff --git a/551/TumorCenter_CD8_block11_x2_y6_patient551_1.json b/551/TumorCenter_CD8_block11_x2_y6_patient551_1.json new file mode 100644 index 0000000000000000000000000000000000000000..850b8fd3b0b87a6ed9edfbf0fa54bd44e1871059 --- /dev/null +++ b/551/TumorCenter_CD8_block11_x2_y6_patient551_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 14492.3, + "Num Detections": 12676, + "Num Negative": 12228, + "Num Positive": 448, + "Positive %": 3.534, + "Num Positive per mm^2": 277.45 + } +} \ No newline at end of file diff --git a/551/history_text.txt b/551/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a4e36b29122af284207aa70b4564386768ef1d7 --- /dev/null +++ b/551/history_text.txt @@ -0,0 +1 @@ +The patient had a histologically confirmed cT2 cN0 uvular carcinoma. The preoperative CT of the neck and thorax showed a mass on the uvula on the right anterior palatal arch and extending into the right tonsillar lobe. There were no suspicious lymph nodes and no malignant round foci in the thorax. Thus, the above-mentioned measures were indicated. \ No newline at end of file diff --git a/551/icd_codes.txt b/551/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d1dcbef33712e70bb537f5f0d27e46c0f20ebcd --- /dev/null +++ b/551/icd_codes.txt @@ -0,0 +1 @@ +Uvulakarzinom[C05.2 ] \ No newline at end of file diff --git a/551/ops_codes.txt b/551/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d76e48cab4e1b1947f6442b477052ef1ac4c6bf1 --- /dev/null +++ b/551/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] ohne Rekonstruktion[5-296.00 ] Uvulatumorresektion[5-272.0 ] \ No newline at end of file diff --git a/551/patient_clinical_data.json b/551/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d810edbe4d3ac15f5fe728f1b5ea78c60104cb05 --- /dev/null +++ b/551/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/551/patient_pathological_data.json b/551/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..83618df8cd90d8fea8c0bfd50fba02ad8764a986 --- /dev/null +++ b/551/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "551", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/551/surgery_description.txt b/551/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..77c13084ea2128fe259cc6442193bc93d98ee4a1 --- /dev/null +++ b/551/surgery_description.txt @@ -0,0 +1 @@ +Transorale TU-Resektion diff --git a/551/surgery_report.txt b/551/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b16252617ea6893cd41910173d311b94b440d665 --- /dev/null +++ b/551/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and transoral endotracheal intubation by the anesthesia colleagues, positioning of the patient by the surgeon. First of all, placement of the mouth blocker and inspection of the oral cavity. A slightly exophytic, exulcerated mass was found, localized more on the posterior surface of the uvula. On palpation, the left half of the uvula, the cranial part of the anterior and posterior palatal arch and the cranial half of the left tonsil were clearly indurated. Thus, under constant control by means of palpation, the uvula was recut starting from the left upper tonsil pole, with a macroscopic safety margin of 1 cm. Removal of the uvula. Transfer to the right side. Taking the anterior and posterior palatal arch on the right. Constant palpatory control. Careful dissection, macroscopically in healthy tissue. The induration is carefully traced caudally in the right tonsillar lobe. Phases of the constrictor pharyngeus medius muscle are taken. Hemostasis by means of bipolar coagulation. This results in a uvular resection with a tumor tonsillectomy on the right side. The specimen is thread-marked and sent for frozen section examination. The pathology colleagues announced their findings by telephone. Tumor cells were found in the cranial part of the specimen, forming a vocal margin. Otherwise, the tumor appeared to be completely removed from the healthy tissue with a minimum distance of 0.1 cm at the level of the middle soft tissue margin (left tonsil lobe). Thus, generous resection cranially, removal of a marginal sample cranially and resection in the former left tonsil lobe in the entire length from cranial to caudal. The three specimens (cranial resection, cranial margin specimen, soft tissue resection margin) are sent for final histology. Careful hemostasis with bipolar coagulation. Careful inspection of the surgical site. Insertion of a gastric tube. Completion of the procedure without bleeding and without complications. Conclusion: Uvular resection with tumor tonsillectomy on the right side. In a cT2 cN0 oral cavity (uvula) - oropharynx (anterior and posterior palatal arch, tonsil) carcinoma. Bilateral neck dissection with PEG placement is planned in 10 days. Taking into account the surgical defect on the uvula and in the area of the right oropharynx, good postoperative swallowing function is to be expected and flap coverage is therefore not necessary. \ No newline at end of file diff --git a/552/InvasionFront_CD3_block22_x3_y1_patient552_0.json b/552/InvasionFront_CD3_block22_x3_y1_patient552_0.json new file mode 100644 index 0000000000000000000000000000000000000000..679ce705de121eb7f5b0e2ddee141578a94ad9ee --- /dev/null +++ b/552/InvasionFront_CD3_block22_x3_y1_patient552_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12243.5, + "Centroid Y µm": 13917.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/552/InvasionFront_CD3_block22_x4_y1_patient552_1.json b/552/InvasionFront_CD3_block22_x4_y1_patient552_1.json new file mode 100644 index 0000000000000000000000000000000000000000..20bba86a7c71758de39a2979e97a092aecfffb75 --- /dev/null +++ b/552/InvasionFront_CD3_block22_x4_y1_patient552_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15017.0, + "Centroid Y µm": 13967.6, + "Num Detections": 7320, + "Num Negative": 7082, + "Num Positive": 238, + "Positive %": 3.251, + "Num Positive per mm^2": 201.55 + } +} \ No newline at end of file diff --git a/552/InvasionFront_CD8_block22_x3_y1_patient552_0.json b/552/InvasionFront_CD8_block22_x3_y1_patient552_0.json new file mode 100644 index 0000000000000000000000000000000000000000..18f314223e4cba9688a4c387cee029a4a923d55f --- /dev/null +++ b/552/InvasionFront_CD8_block22_x3_y1_patient552_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 2873.5, + "Num Detections": 15879, + "Num Negative": 15823, + "Num Positive": 56, + "Positive %": 0.3527, + "Num Positive per mm^2": 28.66 + } +} \ No newline at end of file diff --git a/552/InvasionFront_CD8_block22_x4_y1_patient552_1.json b/552/InvasionFront_CD8_block22_x4_y1_patient552_1.json new file mode 100644 index 0000000000000000000000000000000000000000..84550c127a643e652d491195e3e1ad482c76f86d --- /dev/null +++ b/552/InvasionFront_CD8_block22_x4_y1_patient552_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 2698.6, + "Num Detections": 20974, + "Num Negative": 19486, + "Num Positive": 1488, + "Positive %": 7.094, + "Num Positive per mm^2": 630.12 + } +} \ No newline at end of file diff --git a/552/TumorCenter_CD3_block22_x3_y1_patient552_0.json b/552/TumorCenter_CD3_block22_x3_y1_patient552_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c0360e9bae7112bc0a6d570577a4e9b065d31298 --- /dev/null +++ b/552/TumorCenter_CD3_block22_x3_y1_patient552_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12043.6, + "Centroid Y µm": 3602.3, + "Num Detections": 18798, + "Num Negative": 18667, + "Num Positive": 131, + "Positive %": 0.6969, + "Num Positive per mm^2": 57.18 + } +} \ No newline at end of file diff --git a/552/TumorCenter_CD3_block22_x4_y1_patient552_1.json b/552/TumorCenter_CD3_block22_x4_y1_patient552_1.json new file mode 100644 index 0000000000000000000000000000000000000000..71aded18f532134fd31af4963f0d9f4d3e4a1939 --- /dev/null +++ b/552/TumorCenter_CD3_block22_x4_y1_patient552_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14622.1, + "Centroid Y µm": 3655.2, + "Num Detections": 23729, + "Num Negative": 23547, + "Num Positive": 182, + "Positive %": 0.767, + "Num Positive per mm^2": 74.23 + } +} \ No newline at end of file diff --git a/552/TumorCenter_CD8_block22_x3_y1_patient552_0.json b/552/TumorCenter_CD8_block22_x3_y1_patient552_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a818e95f351fcf25dabce56f2da12c56befa1930 --- /dev/null +++ b/552/TumorCenter_CD8_block22_x3_y1_patient552_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14417.4, + "Centroid Y µm": 12543.4, + "Num Detections": 19591, + "Num Negative": 19142, + "Num Positive": 449, + "Positive %": 2.292, + "Num Positive per mm^2": 201.96 + } +} \ No newline at end of file diff --git a/552/TumorCenter_CD8_block22_x4_y1_patient552_1.json b/552/TumorCenter_CD8_block22_x4_y1_patient552_1.json new file mode 100644 index 0000000000000000000000000000000000000000..08e5d8d1cfb3d51264e8f161914beb2cf377afaa --- /dev/null +++ b/552/TumorCenter_CD8_block22_x4_y1_patient552_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16841.1, + "Centroid Y µm": 12593.3, + "Num Detections": 22235, + "Num Negative": 20724, + "Num Positive": 1511, + "Positive %": 6.796, + "Num Positive per mm^2": 653.05 + } +} \ No newline at end of file diff --git a/552/history_text.txt b/552/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/552/icd_codes.txt b/552/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/552/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/552/ops_codes.txt b/552/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..893eca3421424b3b2e1c8e35cd9a905672b27b38 --- /dev/null +++ b/552/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Andere partielle Laryngektomie: Teilresektion, frontolateral (Leroux-Robert)[5-302.7 ] \ No newline at end of file diff --git a/552/patient_clinical_data.json b/552/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e984a4bcbb855776d8f61368e6d593c3c7838e76 --- /dev/null +++ b/552/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2008, + "age_at_initial_diagnosis": 70, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/552/patient_pathological_data.json b/552/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3228c40fbca5b61336c00e1112e779eca078a072 --- /dev/null +++ b/552/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "552", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 4, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/552/surgery_description.txt b/552/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..eb059a728d8fef20f4ca7e5d5fbb1b252a56be99 --- /dev/null +++ b/552/surgery_description.txt @@ -0,0 +1 @@ +KK-Teilresektion nach Leroux Robert diff --git a/552/surgery_report.txt b/552/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..05f706ae8df77f04240fd7bab56d176d584d87d6 --- /dev/null +++ b/552/surgery_report.txt @@ -0,0 +1 @@ +At the beginning of the operation, the surgeon positions the patient. After induction of anesthesia, alcohol disinfection and infiltration anesthesia are performed. A zigzag incision is then made in the midline. Careful dissection through the subcutaneous tissue to the prelaryngeal muscles. This is pushed apart in the midline. Now expose the larynx from the incisura to below the cricoid cartilage. Tissue in the form of a pyramidal lobe of the thyroid gland is visible below the cricoid cartilage. However, after clamping and ligation, this piece of tissue is removed and sent for final histology. The larynx is then dissected in the midline. Sawing open with the wheel. As described above, the tumor is limited to the right vocal fold. It extends to the anterior commissure, but not beyond, and is firmly attached to the anterior part of the thyroid cartilage and cannot be moved. Careful dissection with pointed scissors and the Freer. Detachment of the tumor then also with the punch from the anterior thyroid cartilage. Therefore possible R1 resection here. Dissection then dorsally up to the arytenoid cartilage. The tumor preparation is sent for final histology. Now saw out the triangle from the thyroid cartilage where the tumor had grown in the anterior region. This is sent as the 2nd specimen for final histology. Now take representative edge samples. These are all found to be tumor-free by from the pathology department in the frozen section. Careful hemostasis. Irrigation of the wound. Adaptation of the thyroid cartilage. Then closure of the lower triangle using muscle flaps. Subsequent insertion of a flap and adaptation of the prelaryngeal muscles in the midline. Now 2-layer wound closure. Completion of the procedure without any indication of complications. \ No newline at end of file diff --git a/553/InvasionFront_CD3_block15_x1_y11_patient553_0.json b/553/InvasionFront_CD3_block15_x1_y11_patient553_0.json new file mode 100644 index 0000000000000000000000000000000000000000..698f7adb483624a04fd7042394a8fd8cc9860484 --- /dev/null +++ b/553/InvasionFront_CD3_block15_x1_y11_patient553_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 38129.8, + "Num Detections": 8844, + "Num Negative": 8684, + "Num Positive": 160, + "Positive %": 1.809, + "Num Positive per mm^2": 185.78 + } +} \ No newline at end of file diff --git a/553/InvasionFront_CD3_block15_x2_y11_patient553_1.json b/553/InvasionFront_CD3_block15_x2_y11_patient553_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9c6384c6da94a4405abd421e38f24dfd915426c3 --- /dev/null +++ b/553/InvasionFront_CD3_block15_x2_y11_patient553_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9345.1, + "Centroid Y µm": 37805.0, + "Num Detections": 9016, + "Num Negative": 8867, + "Num Positive": 149, + "Positive %": 1.653, + "Num Positive per mm^2": 147.51 + } +} \ No newline at end of file diff --git a/553/InvasionFront_CD8_block15_x1_y11_patient553_0.json b/553/InvasionFront_CD8_block15_x1_y11_patient553_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aba6852aa4df61608de0744b03dfb67682218464 --- /dev/null +++ b/553/InvasionFront_CD8_block15_x1_y11_patient553_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4452.7, + "Centroid Y µm": 27133.6, + "Num Detections": 18850, + "Num Negative": 18679, + "Num Positive": 171, + "Positive %": 0.9072, + "Num Positive per mm^2": 96.16 + } +} \ No newline at end of file diff --git a/553/InvasionFront_CD8_block15_x2_y11_patient553_1.json b/553/InvasionFront_CD8_block15_x2_y11_patient553_1.json new file mode 100644 index 0000000000000000000000000000000000000000..604df724eeaeaae0a65e1813e8e06badd53b9f9e --- /dev/null +++ b/553/InvasionFront_CD8_block15_x2_y11_patient553_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7056.7, + "Centroid Y µm": 27036.2, + "Num Detections": 10377, + "Num Negative": 10245, + "Num Positive": 132, + "Positive %": 1.272, + "Num Positive per mm^2": 89.94 + } +} \ No newline at end of file diff --git a/553/TumorCenter_CD3_block15_x1_y11_patient553_0.json b/553/TumorCenter_CD3_block15_x1_y11_patient553_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6635a88317f1c7ba238ae363eb39b0d91c8d5595 --- /dev/null +++ b/553/TumorCenter_CD3_block15_x1_y11_patient553_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3798.0, + "Centroid Y µm": 30608.8, + "Num Detections": 13562, + "Num Negative": 13364, + "Num Positive": 198, + "Positive %": 1.46, + "Num Positive per mm^2": 91.34 + } +} \ No newline at end of file diff --git a/553/TumorCenter_CD3_block15_x2_y11_patient553_1.json b/553/TumorCenter_CD3_block15_x2_y11_patient553_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fcf77089be4b1fc37a810c017b71d6a6a4f60f19 --- /dev/null +++ b/553/TumorCenter_CD3_block15_x2_y11_patient553_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 30683.8, + "Num Detections": 23870, + "Num Negative": 22735, + "Num Positive": 1135, + "Positive %": 4.755, + "Num Positive per mm^2": 486.01 + } +} \ No newline at end of file diff --git a/553/TumorCenter_CD8_block15_x1_y11_patient553_0.json b/553/TumorCenter_CD8_block15_x1_y11_patient553_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3481491eca761d160249cc495e9699baffb0efa8 --- /dev/null +++ b/553/TumorCenter_CD8_block15_x1_y11_patient553_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 27185.6, + "Num Detections": 16493, + "Num Negative": 16384, + "Num Positive": 109, + "Positive %": 0.6609, + "Num Positive per mm^2": 49.29 + } +} \ No newline at end of file diff --git a/553/TumorCenter_CD8_block15_x2_y11_patient553_1.json b/553/TumorCenter_CD8_block15_x2_y11_patient553_1.json new file mode 100644 index 0000000000000000000000000000000000000000..49a24426fafabb1eb84aa881a617208aae5615a6 --- /dev/null +++ b/553/TumorCenter_CD8_block15_x2_y11_patient553_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8920.3, + "Centroid Y µm": 27260.6, + "Num Detections": 26169, + "Num Negative": 25372, + "Num Positive": 797, + "Positive %": 3.046, + "Num Positive per mm^2": 325.12 + } +} \ No newline at end of file diff --git a/553/history_text.txt b/553/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f580fbca8698bbdfcd8e645d6fe9e083c9255e6 --- /dev/null +++ b/553/history_text.txt @@ -0,0 +1 @@ +The patient has a confirmed tongue margin carcinoma, clinically T2, clinically N0, clinically M0 on the right. After the tumor board presentation, panendoscopy and tumor excision in ITN are performed today. Therefore indication for the above-mentioned operation. Preoperative discussion with the patient took place. The patient had ample opportunity to ask questions about the procedure explained. \ No newline at end of file diff --git a/553/icd_codes.txt b/553/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0f21bd448ba105c4fa6cfba3f3bd06ac2ceca2b --- /dev/null +++ b/553/icd_codes.txt @@ -0,0 +1 @@ +Plattenepithelkarzinom Zungenrand rechts histologisch gesichert[C02.1 R] \ No newline at end of file diff --git a/553/ops_codes.txt b/553/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..757ffec51ce5ddc8666281d67c74180eea628bb4 --- /dev/null +++ b/553/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Zungentumorexzision rechts[5-250.2 ] \ No newline at end of file diff --git a/553/patient_clinical_data.json b/553/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f68f976e4e44d8cc670b40464e09d6e8d1a1712 --- /dev/null +++ b/553/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 77, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/553/patient_pathological_data.json b/553/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..232d1da0e71869d5d31bf30d0edaa4ee4db8f1bd --- /dev/null +++ b/553/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "553", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/553/surgery_description.txt b/553/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9941bc2199447047fef10ca226cad83f6b1dafe9 --- /dev/null +++ b/553/surgery_description.txt @@ -0,0 +1 @@ +Exzision mit Panendoskopie diff --git a/553/surgery_report.txt b/553/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c8a0ba8d57626786e02c3a4dd339c7f0605a03de --- /dev/null +++ b/553/surgery_report.txt @@ -0,0 +1 @@ +After bringing the patient into the operating room, active patient identification and then team time-out. After induction of anesthesia by the anesthesiology colleagues, tracheoscopy is performed with the rigid 0° scope; there are no signs of bifurcation. Careful removal of the instrument. The patient is then intubated transnasally by the surgeon and the anesthesia is deepened by the anesthesia colleagues. Start of flexible esophagogastroscopy. Insertion of the mouth guard after head reclination. The esophageal entrance can be easily visualized. Advance under insufflation and control of the flexible esophageal body up to the stomach. The gastric mucosa is unremarkable, no evidence of stenosis, ............... or inflammation. Peristalsis normal. Retrograde inspection of the cardia, where complete closure of the lower esophageal sphincter can also be seen. Subsequently, after desufflation, careful advancement of the flexible esophagoscope and continuous inspection of the esophageal mucosa. No abnormalities can be seen up to the upper sphincter. Then remove the flexible esophagogastroscope. Transition to rigid hypopharyngoscopy. The piriform sinus, postcricoid region, base of tongue, vallecula and supraglottis can be visualized inconspicuously. Subsequent palpatory inspection of the oral cavity as well as the oropharynx/hypopharynx without resistance. Remove all instruments and swabs. Removal of the mouth guard. Finally, the tumor is visualized in the area of the edge of the tongue on the right side. Careful placement of the mouth retractor. Grasp the tip of the tongue with a suture. The tumor is completely excised using an electric knife and repeated hemostasis. To secure the excision, cranial and caudal marginal incisions are made. Careful hemostasis, aspiration of residual blood and saliva. Removal of all instruments and swabs, removal of the oral retractor. Histology sent to pathology. Conclusion: Panendoscopy with tumor resection of the oral cavity (right edge of tongue) without complications. Awaiting histology, patient presentation if necessary and planning of further treatment. Soft food, intensive mouth rinsing and oral hygiene recommended for the next 3 to 4 days. Adequate analgesia. \ No newline at end of file diff --git a/554/InvasionFront_CD3_block6_x5_y4_patient554_0.json b/554/InvasionFront_CD3_block6_x5_y4_patient554_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8234f8304a7a63aa636f85cf55a660aa1cc056e9 --- /dev/null +++ b/554/InvasionFront_CD3_block6_x5_y4_patient554_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17515.7, + "Centroid Y µm": 10794.3, + "Num Detections": 25566, + "Num Negative": 25099, + "Num Positive": 467, + "Positive %": 1.827, + "Num Positive per mm^2": 172.84 + } +} \ No newline at end of file diff --git a/554/InvasionFront_CD3_block6_x6_y4_patient554_1.json b/554/InvasionFront_CD3_block6_x6_y4_patient554_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4d8f8aa727da27105d334e4a79e96d8312dc3b4a --- /dev/null +++ b/554/InvasionFront_CD3_block6_x6_y4_patient554_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20114.3, + "Centroid Y µm": 10994.2, + "Num Detections": 24659, + "Num Negative": 22912, + "Num Positive": 1747, + "Positive %": 7.085, + "Num Positive per mm^2": 639.68 + } +} \ No newline at end of file diff --git a/554/InvasionFront_CD8_block6_x5_y2_patient554_0.json b/554/InvasionFront_CD8_block6_x5_y2_patient554_0.json new file mode 100644 index 0000000000000000000000000000000000000000..75f58d0ae99f74dc488ee82fa99a248fcabf59f6 --- /dev/null +++ b/554/InvasionFront_CD8_block6_x5_y2_patient554_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18015.5, + "Centroid Y µm": 5122.3, + "Num Detections": 19575, + "Num Negative": 19107, + "Num Positive": 468, + "Positive %": 2.391, + "Num Positive per mm^2": 203.91 + } +} \ No newline at end of file diff --git a/554/InvasionFront_CD8_block6_x6_y2_patient554_1.json b/554/InvasionFront_CD8_block6_x6_y2_patient554_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ca8a1b315214087728696dba96593a37be8bcad1 --- /dev/null +++ b/554/InvasionFront_CD8_block6_x6_y2_patient554_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20664.1, + "Centroid Y µm": 5322.2, + "Num Detections": 20521, + "Num Negative": 19958, + "Num Positive": 563, + "Positive %": 2.744, + "Num Positive per mm^2": 234.91 + } +} \ No newline at end of file diff --git a/554/TumorCenter_CD3_block6_x5_y2_patient554_0.json b/554/TumorCenter_CD3_block6_x5_y2_patient554_0.json new file mode 100644 index 0000000000000000000000000000000000000000..21bc07e492be076682a73ece12ebc2260f3397c9 --- /dev/null +++ b/554/TumorCenter_CD3_block6_x5_y2_patient554_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 4972.4, + "Num Detections": 19873, + "Num Negative": 19663, + "Num Positive": 210, + "Positive %": 1.057, + "Num Positive per mm^2": 86.91 + } +} \ No newline at end of file diff --git a/554/TumorCenter_CD3_block6_x6_y2_patient554_1.json b/554/TumorCenter_CD3_block6_x6_y2_patient554_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8488b782dbac6a00f6cdc1dd59b9feb328d7c3e8 --- /dev/null +++ b/554/TumorCenter_CD3_block6_x6_y2_patient554_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 5097.3, + "Num Detections": 19464, + "Num Negative": 19210, + "Num Positive": 254, + "Positive %": 1.305, + "Num Positive per mm^2": 111.81 + } +} \ No newline at end of file diff --git a/554/TumorCenter_CD8_block6_x5_y2_patient554_0.json b/554/TumorCenter_CD8_block6_x5_y2_patient554_0.json new file mode 100644 index 0000000000000000000000000000000000000000..66bd1e60be983110ddc60755cd93cfcd574372e4 --- /dev/null +++ b/554/TumorCenter_CD8_block6_x5_y2_patient554_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 5322.2, + "Num Detections": 22597, + "Num Negative": 22512, + "Num Positive": 85, + "Positive %": 0.3762, + "Num Positive per mm^2": 33.05 + } +} \ No newline at end of file diff --git a/554/TumorCenter_CD8_block6_x6_y2_patient554_1.json b/554/TumorCenter_CD8_block6_x6_y2_patient554_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4e2ee0d3a88e298e95d5c774c875406111193d10 --- /dev/null +++ b/554/TumorCenter_CD8_block6_x6_y2_patient554_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 5322.2, + "Num Detections": 23660, + "Num Negative": 23617, + "Num Positive": 43, + "Positive %": 0.1817, + "Num Positive per mm^2": 16.8 + } +} \ No newline at end of file diff --git a/554/history_text.txt b/554/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ffff5b97a4d58fc324f0cb21fe30cccf1d5a9916 --- /dev/null +++ b/554/history_text.txt @@ -0,0 +1 @@ +The patient had noticed a cervical mass on the right side <2018>. She had also noticed dysphagia. The external CT scan from <2018> showed a high-grade cT1 cN2b cM0 tonsillar carcinoma on the right side. There is an indication for the above-mentioned operation. \ No newline at end of file diff --git a/554/icd_codes.txt b/554/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..db2d5a86a2f56199b8dc155060586ba21f58dec9 --- /dev/null +++ b/554/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] Halslymphknotenmetastasen[C77.0 R] \ No newline at end of file diff --git a/554/ops_codes.txt b/554/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed5ffb06d2933b17c8f7186d0b764270ef2216d0 --- /dev/null +++ b/554/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie [ohne Adenotomie] mit Dissektionstechnik[5-281.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Ösophagoskopie[1-630.x ] Sonstige diagnostische Tracheobronchoskopie[1-620.x ] \ No newline at end of file diff --git a/554/patient_clinical_data.json b/554/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f6007f084c7980440f48322a939454bc7871c124 --- /dev/null +++ b/554/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 66, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/554/patient_pathological_data.json b/554/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5f3fd510fa75d17e4265958f894de25c685b3475 --- /dev/null +++ b/554/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "554", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 48, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/554/surgery_description.txt b/554/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..22047c2776f9ba23e81ffcf17c35d3af4a25b979 --- /dev/null +++ b/554/surgery_description.txt @@ -0,0 +1 @@ +Tumortonsillektomie rechts, Panendoskopie diff --git a/554/surgery_report.txt b/554/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..335cffb6577b9de9324b8943e838c1b795a07fc0 --- /dev/null +++ b/554/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater and positioning of the patient. Introductory consultation with the anesthesiologist and performance of the team time-out. With Cormack I, the patient can be intubated without any problems after an unremarkable tracheoscopy. Now start with esophagogastroscopy, here the esophagus and gastric mucosa are non-irritating, inconspicuous and without evidence of bleeding or a mass. Palpation and inspection of the oral cavity. The right tonsil is rough to palpate, especially in the upper area, the left tonsil is palpable without irritation, as is the base of the tongue. Now entering with the Kleinsasser tube C, the vallecula and epiglottis are inconspicuous, as is the base of the tongue; the pharyngeal side and posterior walls as well as the postcricoid region are also inconspicuous. With good adjustability, the larynx can be adjusted up to the anterior commissure, the vocal folds are also inconspicuous, the piriform sinus can be stretched open on both sides without any problems. Now insert the Mc Ivor blade and inspect the tonsil region on the right side. Here an exophytic mass is seen in the upper third of the tonsil, the caudal pole is free and can be luxated without difficulty, the middle of the tonsil and the upper pole can also be luxated without difficulty, but the exophytic mass in the cranial region extends approximately 0.5 cm from the upper tonsil pole to the anterior palatal arch. For this reason, the mucosal incision close to the uvula is made closer to the uvula than in a normal TE and a section of the anterior palatal arch is also resected, so that the tumor is incised by approx. 4 mm. Further careful dissection of the tonsil, the tonsil can be adjusted and luxated without any problems and the fibers can be stretched open and the tonsil separated from the tissue without any problems. The tonsil is not firmly attached to the tonsil bed at either end. Successive detachment of the tonsil without increased coagulation in the upper area to allow inspection of the wound edges. The resection is performed in the remaining area with a minimum distance of 7 mm, in the caudal area now dissection according to the dissection technique with bipolar coagulation and removal of the tonsil. The anterior and posterior palatal arch could be spared. Basally, the tonsil was removed deeper than in normal TE, but without opening the parapharyngeal space. Palpation revealed no further evidence of a mass in the tonsillar lobe. After careful hemostasis with bipolar coagulation, there is no evidence of increased bleeding. Relax for 5 minutes and wait, after reinsertion of the Mc Ivor spatula the wound bed is still dry. End the operation. Inspection of the tonsil. The upper pole in particular is hard to palpate, it is surrounded on all sides by easily movable mucosa, the exophytic mass is also removed by inspection and palpation in healthy tissue. The minimum distance of 4 mm on the anterior palatal arch is approximately 0.5 cm below the cranial pole. Suture marking and sending in the tonsil. Conclusion: cT1 cN2b tonsillar carcinoma on the right side. In today's operation, frozen sections were not performed and the specimen was sent for urgent histology. The histology should be discussed in the interdisciplinary tumor conference, including the performance of the neck dissection. The planning of the further procedure should be discussed. \ No newline at end of file diff --git a/555/InvasionFront_CD3_block11_x1_y7_patient555_0.json b/555/InvasionFront_CD3_block11_x1_y7_patient555_0.json new file mode 100644 index 0000000000000000000000000000000000000000..09588e102b1e4a89dd935c9cb6652d045c604942 --- /dev/null +++ b/555/InvasionFront_CD3_block11_x1_y7_patient555_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3473.2, + "Centroid Y µm": 17290.8, + "Num Detections": 18115, + "Num Negative": 17576, + "Num Positive": 539, + "Positive %": 2.975, + "Num Positive per mm^2": 234.97 + } +} \ No newline at end of file diff --git a/555/InvasionFront_CD3_block11_x2_y7_patient555_1.json b/555/InvasionFront_CD3_block11_x2_y7_patient555_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aa4828806f6f7357579bb57581f8848e51d9d399 --- /dev/null +++ b/555/InvasionFront_CD3_block11_x2_y7_patient555_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5921.9, + "Centroid Y µm": 17190.9, + "Num Detections": 20677, + "Num Negative": 19366, + "Num Positive": 1311, + "Positive %": 6.34, + "Num Positive per mm^2": 547.46 + } +} \ No newline at end of file diff --git a/555/InvasionFront_CD8_block11_x1_y7_patient555_0.json b/555/InvasionFront_CD8_block11_x1_y7_patient555_0.json new file mode 100644 index 0000000000000000000000000000000000000000..67761618d5a61045ff647a67bf02be1f617216f9 --- /dev/null +++ b/555/InvasionFront_CD8_block11_x1_y7_patient555_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 28146.6, + "Num Detections": 16745, + "Num Negative": 16579, + "Num Positive": 166, + "Positive %": 0.9913, + "Num Positive per mm^2": 74.5 + } +} \ No newline at end of file diff --git a/555/InvasionFront_CD8_block11_x2_y7_patient555_1.json b/555/InvasionFront_CD8_block11_x2_y7_patient555_1.json new file mode 100644 index 0000000000000000000000000000000000000000..63bda79c65825180eadebe9b9c281090b8d28a81 --- /dev/null +++ b/555/InvasionFront_CD8_block11_x2_y7_patient555_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8865.8, + "Centroid Y µm": 28112.7, + "Num Detections": 18642, + "Num Negative": 18338, + "Num Positive": 304, + "Positive %": 1.631, + "Num Positive per mm^2": 132.05 + } +} \ No newline at end of file diff --git a/555/TumorCenter_CD3_block11_x1_y7_patient555_0.json b/555/TumorCenter_CD3_block11_x1_y7_patient555_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2519d09d100cace7cb335a271fb1f352758ee593 --- /dev/null +++ b/555/TumorCenter_CD3_block11_x1_y7_patient555_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6697.0, + "Centroid Y µm": 16834.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/555/TumorCenter_CD3_block11_x2_y7_patient555_1.json b/555/TumorCenter_CD3_block11_x2_y7_patient555_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d57d12a71f6958531552122d85e589a89994f434 --- /dev/null +++ b/555/TumorCenter_CD3_block11_x2_y7_patient555_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9352.8, + "Centroid Y µm": 17109.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/555/TumorCenter_CD8_block11_x1_y7_patient555_0.json b/555/TumorCenter_CD8_block11_x1_y7_patient555_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4852f751445290a31a589d2018714c02058e0914 --- /dev/null +++ b/555/TumorCenter_CD8_block11_x1_y7_patient555_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3715.7, + "Centroid Y µm": 17789.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/555/TumorCenter_CD8_block11_x2_y7_patient555_1.json b/555/TumorCenter_CD8_block11_x2_y7_patient555_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8130bb4337409873550496ea44f74796bea7aeeb --- /dev/null +++ b/555/TumorCenter_CD8_block11_x2_y7_patient555_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6646.5, + "Centroid Y µm": 17091.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/555/history_text.txt b/555/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1f3e3f5b78e620927220bfd723e1af5caa2c9156 --- /dev/null +++ b/555/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 oropharyngeal carcinoma on the right was histologically confirmed during a panendoscopy <2011>. Sonographically V.a. cN2c neck status. No evidence of distant metastases on external CT staging. The patient has thrombocytopenia of unknown origin. \ No newline at end of file diff --git a/555/icd_codes.txt b/555/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/555/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/555/ops_codes.txt b/555/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2e58bc5b5633ef62e027733c2bfc302b388f4476 --- /dev/null +++ b/555/ops_codes.txt @@ -0,0 +1 @@ +Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Transplantation sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.93 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] \ No newline at end of file diff --git a/555/patient_clinical_data.json b/555/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..09975158c59c725779f954599528fcee8da5e313 --- /dev/null +++ b/555/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab + carboplatin", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/555/patient_pathological_data.json b/555/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8d9182b4e3373e3fd5cdd3844b3eb674ab7b0d8d --- /dev/null +++ b/555/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "555", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 38.0, + "number_of_resected_lymph_nodes": 93, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/555/surgery_description.txt b/555/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..49da8fd862aa00a5fc4d22c129681f68ef976c39 --- /dev/null +++ b/555/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion, Neck diss bds., Defektdeckung, Freier Lappen (Radialis), PEG-Anlage diff --git a/555/surgery_report.txt b/555/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c83b1d023ccb6556bde07d04594b305c810bfd7 --- /dev/null +++ b/555/surgery_report.txt @@ -0,0 +1 @@ +Initially after bronchoscopic intubation transnasally via the anesthesia colleagues, start with PEG insertion. For this purpose, insertion with the gastroscope under laryngoscopic control. Easy to see through to the stomach. There are clear signs of chronic gastritis with cobblestone-like changes to the mucosa and petechial bleeding, but no suspicious changes. With excellent diaphanoscopy, the stomach was punctured without any problems and the PEG tube was inserted using the usual thread pull-through method. On reflection, inconspicuous mucosal findings in the area of the oesophagus. After positioning and preparing the patient, a pharyngoscopy is performed. This reveals an exophytic tumor on the right side of the left tonsil region which extends over the anterior palatal arch into the uvula. Soft palate infiltration here at the free edge. Good distance to the hard palate. Complete infiltration of the posterior palatal arch. The posterior pharyngeal wall itself is again tumor-free. At the caudal tonsil pole there is an extension towards the pharyngeal side wall, here the tumor is clearly immobile, in the cranial tonsil area good mobility of the tumor. Insertion of the tonsil plug, good overview below. Transoral resection of the tumor using the monopolar and dissection technique. Select a safety margin of a good 1 ˝ cm, take the uvula with you, enter on the left side, subtotal resection of the soft palate to obtain the safety margin. Now good overview, here no dorsal growth towards the nasopharynx. Good delineation here. Complete resection of the anterior palatal arch. Here the tumor can be safely dissected away with a clear shifting layer to the musculature. Removal of the entire posterior palatal arch, resection up to approx. half of the posterior pharyngeal wall. Resection down to the prevertebral fascia. Now in the direction of the caudal tonsil pole, it can be seen that the tumor clearly extends like a cone towards the neck and the course of the carotid artery. This is confirmed by the CT findings. Therefore, the decision was made to obtain enoral mucosa-covering margin samples and to resect further transcervically. The marginal samples were found to be tumor-free in the frozen section diagnosis. Now turn to the neck dissection on the right side and complete the tumor resection. Skin incision at the anterior margin of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and preservation of the external jugular vein, an anterior course is ligated and removed. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. A clear lymph node conglomerate can now be seen in Level II to III in the area of the jugulo-facial angle, which is firmly attached and palpable in the direction of the tonsil lobe. In addition, multiple spherical, coarse and caked, highly suspicious nodes are palpable throughout level 5. Expose the accessory nerve and secure the nerve. Now open dissection of the internal jugular vein. Clear the anterior neck preparation while preserving the superior thyroid artery and securing the hypoglossal nerve. The lymph node conglomerate is directly exposed here. First remove the accessorius triangle and level 5, where the lymph node conglomerate is clearly embedded and infiltrated in the cervical plexus. This is now subtotally resected, the lymph node conglomerate extends nuchally directly under the skin. Sharp detachment at the skin with in sano resection. Macroscopically no lymph node openings. Resection up to level 5, ligation and removal of the transverse cervical artery and the very strong accompanying veins. Resection up to the mediastinum, but no further dissection here, no exposure of the subclavian vein, finally no evidence of lymph leakage. The cervical plexus here is subtotally resected, preserved accssorius nerve. Now ligate in the area of the jugulo-facial angle with partial but clear infiltration of the V. facilais and remove the vein. Expose the carotid artery with exit of the superior thyroid artery, the lingual artery extends into the lymph node conglomerate and is questionably infiltrated, this is ligated and removed. Dissection of the hypoglossal nerve, which is clearly adjacent but not infiltrated. Now expose the external carotid artery, after securing the bulb and the outlet of the internal carotid artery. It is now apparent that the cervical lymph node conglomerate is continuously moving in the direction of the tumor, therefore en bloc resection, resection was already performed previously. Now resection of the digastric muscle, resection and connection of the inner and outer resection surfaces in the area of the posterior pharyngeal wall, passing the external carotid artery, safe removal of the tumor here, now only the carotid artery and the prevertebral fascia remain dorsally. With careful protection of the hypoglossal nerve, resection of the tumor with at least 1 ˝ cm mucosal clearance. Resection extends to the level of the vallecula. This results in an en bloc resection of the tumor with the lymph node conglomerate extending cervically. To assess the tumor in frozen section diagnostics, however, the attached lymph node conglomerate is now removed and specially marked using a ligature. The specimen is thread-marked for frozen section diagnostics. Except for the deliberately placed margin, tumor-free margins are visible on all sides, so the situation is now R0. Now measure the enoral defect and lift a radialis graft from the left forearm parallel to the neck dissection performed here. After marking the 11 x 6 cm graft, the arm is unwrapped and the tourniquet is placed. Cut around the specimen, take along the cephalic vein and a skin monitor. Exposure of the cephalic vein. Performing the Hayden maneuver and exposing the ramus superficialis nervi radialis and exposing the peripheral vascular pedicle. Ligation of the vascular pedicle. Now careful subpastial preparation with careful protection of the radial nerve branch, free preparation of the graft up to the crook of the elbow. Here the very strong ulnar artery and the relatively slender anterior interosseous artery are secured. Preservation of both vessels. Now expose the wide venous bridge to the superficial venous system. Preservation of the bridge, elevation of a strong cubital venous branch. Reopening of the tourniquet. Regular flap vitality can be seen. Careful wound inspection and hemostasis. Later removal of the graft before insertion with removal of the artery and preservation of the anterior interosseous artery. After hemostasis, careful, two-layer wound closure and incorporation of the full-thickness skin graft lifted from the right groin. Finally, insertion of a vacuum sealing bandage and application of the Cramer splint. For full-thickness skin harvesting, cut around an 11 x 6 cm skin graft in the right groin. Strictly cutaneous elevation of the graft. Careful hemostasis, subcutaneous mobilization of the surrounding tissue and, after insertion of a 10-gauge Redon drainage, careful two-layer wound closure and application of a wound dressing. Now first perform the neck dissection on the left side. To do this, also make a skin incision on the front edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure of the external jugular vein and the auricularis magnus nerve. Preservation of the structures. However, the external jugular vein is relatively weak here. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Exposure of the anterior neck preparation with careful protection of the cervical artery, the superior thyroid artery, the facial vein and the hypoglossal nerve. Exposure of the accessorius nerve, free preparation of the internal jugular vein. There are no conspicuous changes at levels 2 to 4, but again at level 5 a partly conglomerate-like, coarse lymph node and macroscopically, palpatorily clearly suspicious, but here without infiltration of the surrounding tissue. Therefore, after evacuation of the accessorius triangle and careful preservation of the nerve, resection of the lymph nodes and preservation of the cervical plexus. Careful caudal inspection. Exposure and preservation of the transverse cervical artery, no evidence of lymphatic leakage caudally and, after careful inspection, wound irrigation with Ringer's solution and careful two-layer wound closure after insertion of a 10-gauge Redon drain. The tracheotomy is now performed due to the resection defect which extends to the hypopharyngeal side wall. For this purpose, a horizontal skin incision of approx. 1 cm below the cricoid cartilage is made. Cut through the skin and subcutaneous tissue. Exposure and transection of the intrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Bipolar coagulation of the thyroid isthmus, which is very weak here. Insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björ flap and successive incision of the tracheostoma with mucocutaneous anastomosis. Subsequent intubation with an 8 mm Woodbridge tube. At the end of the procedure, reintubation without difficulty onto an 8-gauge cannula, which is fixed with sutures and padded with foam. The graft is now inserted. To do this, pull the graft through from transcervical to transoral. First suture the posterior wall of the soft palate. Knock back the graft and reconstruct the soft palate and suture in the area of the tonsil lobe from the enoral side. Finally, transcervical suturing of the graft in the area of the pharyngeal side wall. Final inspection, good fit and correct measurements. Now positioning of the vascular pedicle. Insertion of the skin monitor. Now conditioning of the graft vessels. Conditioning of the superior thyroid artery, which is relatively similar in caliber to the graft artery. Perform the vascular anastomosis with 8.0 Ethilon, carefully adapting the vessel diameters. After reopening, good venous return via the graft. With regular graft perfusion to the venous anastomosis, initial conditioning of the external jugular vein, which remains the same caliber after removal due to the metastases of the facial vein. However, the vein is anastomosed over a long distance, even after removal of the thrombus and repeated irrigation, there is no adequate venous return, so this vein is ligated and removed. Now use of a superior thyroid vein trunk suture to the internal jugular vein, peripheral placement after ligation. Measurement of a size 3.5 coupler and problem-free performance of the copupler anastomosis. Immediate regular venous return and, after reopening of the artery, good circulation and regular flap perfusion as well as excellent flap perfusion in the area of the skin monitor and enorally. Careful positioning of the pedicle and partial fixation to the omohyoid muscle is now performed. Now stable conditions in the area of the anastomosis and especially in the area of the venous anastomosis close to the trunk, which is strong and therefore at risk of kinking. Final inspection. Due to the dissection in level 5 of the extended wound cavity, a 10-gauge Redon drain is placed here. There is livid skin discoloration in the area of the direct subcutaneous dissection performed, but the surrounding skin is intact with subcutaneous tissue also present, so no resection is performed here. Careful two-layer wound closure. Multiple vitality checks of the flap and skin monitoring and termination of the procedure at this point. Conclusion: Combined transoral, transcervical resection of a markedly aggressive lymphogenic metastatic cT2 cN2c oropharyngeal carcinoma on the right. Intraoperative R0 situation due to the intraoperatively extensive and aggressive metastasis, adjuvant RCT is certainly absolutely necessary here due to the atypical metastasis localization, however, a second malignancy should also be considered in the differential diagnosis. Postoperatively, please perform regular flap vitality checks. Post-operative X-ray preeclampsia on the 8th to 9th postoperative day, followed by a swallowing test if the conditions are intact and, if necessary, a diet with decannulation. In the immediate postoperative course, please check the nuchal skin area where there is a potential risk of necrosis. The patient received intraoperative antibiotics with Unacid 3 g and a single dose of SDH 250 mg. No abnormalities regarding the coagulation situation intraoperatively. \ No newline at end of file diff --git a/556/InvasionFront_CD3_block14_x1_y4_patient556_0.json b/556/InvasionFront_CD3_block14_x1_y4_patient556_0.json new file mode 100644 index 0000000000000000000000000000000000000000..30bc121f63d533501fe9f4f0015f34eeda7ad6bb --- /dev/null +++ b/556/InvasionFront_CD3_block14_x1_y4_patient556_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4822.4, + "Centroid Y µm": 13442.9, + "Num Detections": 19187, + "Num Negative": 18879, + "Num Positive": 308, + "Positive %": 1.605, + "Num Positive per mm^2": 135.12 + } +} \ No newline at end of file diff --git a/556/InvasionFront_CD3_block14_x2_y4_patient556_1.json b/556/InvasionFront_CD3_block14_x2_y4_patient556_1.json new file mode 100644 index 0000000000000000000000000000000000000000..df83ed448b1d0a9c0799e107cf83f73687d48e4d --- /dev/null +++ b/556/InvasionFront_CD3_block14_x2_y4_patient556_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7446.1, + "Centroid Y µm": 13617.8, + "Num Detections": 17249, + "Num Negative": 16770, + "Num Positive": 479, + "Positive %": 2.777, + "Num Positive per mm^2": 215.95 + } +} \ No newline at end of file diff --git a/556/InvasionFront_CD8_block14_x1_y4_patient556_0.json b/556/InvasionFront_CD8_block14_x1_y4_patient556_0.json new file mode 100644 index 0000000000000000000000000000000000000000..af31575fdca4af5cbe3e6a97007eeeb455132098 --- /dev/null +++ b/556/InvasionFront_CD8_block14_x1_y4_patient556_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4947.4, + "Centroid Y µm": 9594.9, + "Num Detections": 16406, + "Num Negative": 15584, + "Num Positive": 822, + "Positive %": 5.01, + "Num Positive per mm^2": 368.55 + } +} \ No newline at end of file diff --git a/556/InvasionFront_CD8_block14_x2_y4_patient556_1.json b/556/InvasionFront_CD8_block14_x2_y4_patient556_1.json new file mode 100644 index 0000000000000000000000000000000000000000..feb28b8e98a8e74a5ebff273fe45dc9e28fa68b3 --- /dev/null +++ b/556/InvasionFront_CD8_block14_x2_y4_patient556_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7471.0, + "Centroid Y µm": 9694.9, + "Num Detections": 16216, + "Num Negative": 14812, + "Num Positive": 1404, + "Positive %": 8.658, + "Num Positive per mm^2": 639.93 + } +} \ No newline at end of file diff --git a/556/TumorCenter_CD3_block14_x1_y4_patient556_0.json b/556/TumorCenter_CD3_block14_x1_y4_patient556_0.json new file mode 100644 index 0000000000000000000000000000000000000000..622ffd440938818bd12b82ad83d855fb4bbecc7e --- /dev/null +++ b/556/TumorCenter_CD3_block14_x1_y4_patient556_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4647.5, + "Centroid Y µm": 9844.8, + "Num Detections": 15796, + "Num Negative": 14565, + "Num Positive": 1231, + "Positive %": 7.793, + "Num Positive per mm^2": 532.35 + } +} \ No newline at end of file diff --git a/556/TumorCenter_CD3_block14_x2_y4_patient556_1.json b/556/TumorCenter_CD3_block14_x2_y4_patient556_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5cfa67c0b381af08d21664fe561aada504826a2b --- /dev/null +++ b/556/TumorCenter_CD3_block14_x2_y4_patient556_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7171.2, + "Centroid Y µm": 10044.7, + "Num Detections": 17814, + "Num Negative": 16628, + "Num Positive": 1186, + "Positive %": 6.658, + "Num Positive per mm^2": 512.28 + } +} \ No newline at end of file diff --git a/556/TumorCenter_CD8_block14_x1_y4_patient556_0.json b/556/TumorCenter_CD8_block14_x1_y4_patient556_0.json new file mode 100644 index 0000000000000000000000000000000000000000..31ec6614d2d40a255b7ee03caaa3259df39c9076 --- /dev/null +++ b/556/TumorCenter_CD8_block14_x1_y4_patient556_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 10544.4, + "Num Detections": 19193, + "Num Negative": 17203, + "Num Positive": 1990, + "Positive %": 10.37, + "Num Positive per mm^2": 858.9 + } +} \ No newline at end of file diff --git a/556/TumorCenter_CD8_block14_x2_y4_patient556_1.json b/556/TumorCenter_CD8_block14_x2_y4_patient556_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8bc82331a34f15e34b0b32457f6e13f025edbd8f --- /dev/null +++ b/556/TumorCenter_CD8_block14_x2_y4_patient556_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 10544.4, + "Num Detections": 18842, + "Num Negative": 17603, + "Num Positive": 1239, + "Positive %": 6.576, + "Num Positive per mm^2": 534.64 + } +} \ No newline at end of file diff --git a/556/history_text.txt b/556/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5de3afef15bf704005b822a3e5dcd368eba5dcf6 --- /dev/null +++ b/556/history_text.txt @@ -0,0 +1 @@ +The patient has noticed a thickening on the right edge of the tongue for several weeks. Clinical signs of leukoplakia. There is a history of nicotine abuse. Therefore indication for the above procedure. \ No newline at end of file diff --git a/556/icd_codes.txt b/556/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3ddecdd44f62c1f8b23c7ad9d8974a133d907128 --- /dev/null +++ b/556/icd_codes.txt @@ -0,0 +1 @@ +Zungenleukoplakie[K13.2 ] V. a. Zungenkarzinom Seitenrand rechts[K13.2 ] \ No newline at end of file diff --git a/556/ops_codes.txt b/556/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..01751c0cf806ac40d50847fea8411c5d325743f3 --- /dev/null +++ b/556/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Probeexzision sonstige Strukturen Mund und Mundhöhle[1-545.x ] Inzision Zungenrand[5-250.0 ] \ No newline at end of file diff --git a/556/patient_clinical_data.json b/556/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..66af2f59b96a547eaaa97689ad385642b3ceb0ba --- /dev/null +++ b/556/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/556/patient_pathological_data.json b/556/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..826e185e336a4d608a2d291f27e04ef5cb3349ec --- /dev/null +++ b/556/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "556", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": null, + "infiltration_depth_in_mm": 0.5 +} \ No newline at end of file diff --git a/556/surgery_description.txt b/556/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3c7b1207e392e8c41faff26f57ab3a962f855f7e --- /dev/null +++ b/556/surgery_description.txt @@ -0,0 +1 @@ +Panendoskopie, Probeentnahme und Exzisionsbiopsie diff --git a/556/surgery_report.txt b/556/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ddb5b1fb43eae03c372a9f1fa7a9ebc1b992c87c --- /dev/null +++ b/556/surgery_report.txt @@ -0,0 +1 @@ +Team time out. Induction of anesthesia by the anesthesia colleagues, followed by rigid tracheoscopy. Inspection of the vocal folds, the subglottic area, the tracheal mucosa. Inconspicuous mucosa everywhere. Then intubation of the patient and head positioning. First of all, enter with the esophagogastroscope under air insufflation and carefully peer into the stomach. The mucosal conditions are inconspicuous everywhere. On retraction, careful inspection of the esophagus, here too everything is unremarkable. Then, the small bore tube type C is inserted while protecting the edentulous upper jaw. Inspection of the tonsils on both sides, the base of the tongue, epiglottis valleculae on both sides, inconspicuous structures here. Further reflection into the hypopharynx, piriform recess can be freely unfolded on both sides and inconspicuous mucosa. The endolarynx is now exposed again, no suspicious lesion is seen here either, the postcricoid region and interaryngeal region are clear. Now insert a Spantex retractor while protecting the lips. Snare the tongue using a Mersilene suture and expose a leukoplakic mass in the area of the posterior third of the tongue, right edge of the tongue. Demonstration on and marking of the resection borders using a monopolar. The lesion is then removed superficially using a monopolar with a sufficient safety margin. The specimen is placed on cork and sent to the pathology (basal = suture marking, red = posterior, blue = anterior, green = towards the top of the tongue, black = towards the underside of the tongue). Careful hemostasis is now performed using a bipolar on the right side. There is also a leukoplakia on the left side, so a PE is also taken on the left edge of the tongue. Now check again for blood dryness, which is present. Removal of the Mersilene suture. Completion of the procedure without complications. Conclusion: removal of leukoplakia at the edge of the tongue on the right in the sense of an excisional biopsy. PE left tongue margin, otherwise unremarkable panendoscopy. \ No newline at end of file diff --git a/557/InvasionFront_CD3_block14_x3_y3_patient557_0.json b/557/InvasionFront_CD3_block14_x3_y3_patient557_0.json new file mode 100644 index 0000000000000000000000000000000000000000..49c9348203b984ea0cb611ca6ab96ce0bcee9fef --- /dev/null +++ b/557/InvasionFront_CD3_block14_x3_y3_patient557_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12193.5, + "Centroid Y µm": 11219.1, + "Num Detections": 25525, + "Num Negative": 24173, + "Num Positive": 1352, + "Positive %": 5.297, + "Num Positive per mm^2": 490.65 + } +} \ No newline at end of file diff --git a/557/InvasionFront_CD3_block14_x4_y3_patient557_1.json b/557/InvasionFront_CD3_block14_x4_y3_patient557_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a2094605dbd8575199e265a230a707c46f006dd5 --- /dev/null +++ b/557/InvasionFront_CD3_block14_x4_y3_patient557_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14942.1, + "Centroid Y µm": 11344.0, + "Num Detections": 17915, + "Num Negative": 16760, + "Num Positive": 1155, + "Positive %": 6.447, + "Num Positive per mm^2": 518.15 + } +} \ No newline at end of file diff --git a/557/InvasionFront_CD8_block14_x3_y3_patient557_0.json b/557/InvasionFront_CD8_block14_x3_y3_patient557_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac658499b4e1191224d80070a29f369b755142a6 --- /dev/null +++ b/557/InvasionFront_CD8_block14_x3_y3_patient557_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12018.6, + "Centroid Y µm": 7346.1, + "Num Detections": 25624, + "Num Negative": 24685, + "Num Positive": 939, + "Positive %": 3.665, + "Num Positive per mm^2": 348.8 + } +} \ No newline at end of file diff --git a/557/InvasionFront_CD8_block14_x4_y3_patient557_1.json b/557/InvasionFront_CD8_block14_x4_y3_patient557_1.json new file mode 100644 index 0000000000000000000000000000000000000000..84cc8fea1079f3b90fdf4cdd671844e6f9f2f4a5 --- /dev/null +++ b/557/InvasionFront_CD8_block14_x4_y3_patient557_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14667.2, + "Centroid Y µm": 7371.1, + "Num Detections": 18672, + "Num Negative": 17966, + "Num Positive": 706, + "Positive %": 3.781, + "Num Positive per mm^2": 312.15 + } +} \ No newline at end of file diff --git a/557/TumorCenter_CD3_block14_x3_y3_patient557_0.json b/557/TumorCenter_CD3_block14_x3_y3_patient557_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c08b5205a9442617d5adcd32c7501a7fd68a7c50 --- /dev/null +++ b/557/TumorCenter_CD3_block14_x3_y3_patient557_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12043.6, + "Centroid Y µm": 7845.8, + "Num Detections": 20594, + "Num Negative": 18146, + "Num Positive": 2448, + "Positive %": 11.89, + "Num Positive per mm^2": 962.9 + } +} \ No newline at end of file diff --git a/557/TumorCenter_CD3_block14_x4_y3_patient557_1.json b/557/TumorCenter_CD3_block14_x4_y3_patient557_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4bce56749159624e099c8c90a5db2cd9f1735d1a --- /dev/null +++ b/557/TumorCenter_CD3_block14_x4_y3_patient557_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14692.2, + "Centroid Y µm": 7945.8, + "Num Detections": 22478, + "Num Negative": 20792, + "Num Positive": 1686, + "Positive %": 7.501, + "Num Positive per mm^2": 650.19 + } +} \ No newline at end of file diff --git a/557/TumorCenter_CD8_block14_x3_y3_patient557_0.json b/557/TumorCenter_CD8_block14_x3_y3_patient557_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ecb2bf2d4fcf86c59159dabc7b03ae9aedbf07e0 --- /dev/null +++ b/557/TumorCenter_CD8_block14_x3_y3_patient557_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 8220.6, + "Num Detections": 19736, + "Num Negative": 18406, + "Num Positive": 1330, + "Positive %": 6.739, + "Num Positive per mm^2": 566.86 + } +} \ No newline at end of file diff --git a/557/TumorCenter_CD8_block14_x4_y3_patient557_1.json b/557/TumorCenter_CD8_block14_x4_y3_patient557_1.json new file mode 100644 index 0000000000000000000000000000000000000000..de9cd483bb99e45375a1476ed2584c43327a5ee0 --- /dev/null +++ b/557/TumorCenter_CD8_block14_x4_y3_patient557_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 8145.7, + "Num Detections": 21609, + "Num Negative": 20905, + "Num Positive": 704, + "Positive %": 3.258, + "Num Positive per mm^2": 288.74 + } +} \ No newline at end of file diff --git a/557/history_text.txt b/557/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..73f1cddf8027a6be60215ab53ee166332e5c09b1 --- /dev/null +++ b/557/history_text.txt @@ -0,0 +1 @@ +A squamous cell carcinoma of the left edge of the tongue was histologically confirmed in domo. Sonographically and computed tomography showed a cN0 cM0 status. Therefore indication for the above procedure. \ No newline at end of file diff --git a/557/icd_codes.txt b/557/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/557/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/557/ops_codes.txt b/557/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dbc9a06bbe64c02686c813cae6a777449039af7d --- /dev/null +++ b/557/ops_codes.txt @@ -0,0 +1 @@ +Zungentumorexzision[5-250.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] \ No newline at end of file diff --git a/557/patient_clinical_data.json b/557/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..86adf79823068b9fc3be85ce2cedabadde6f2968 --- /dev/null +++ b/557/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 48, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/557/patient_pathological_data.json b/557/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..956306421ed9c71faa615e202411c8cdcc9e3617 --- /dev/null +++ b/557/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "557", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/557/surgery_description.txt b/557/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b59630971932896d828a2bb7102b45f4a7b99926 --- /dev/null +++ b/557/surgery_description.txt @@ -0,0 +1 @@ +enorale TU-Resektion, Neck diss. links diff --git a/557/surgery_report.txt b/557/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a37c3cc0ea49f2c4bfc7a4bad9e8a542399e5d25 --- /dev/null +++ b/557/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, transfer the patient to the operating room. Carry out the team time out. Induction of anesthesia and intubation by the anesthesia colleagues. Then, together with , determination of the resection margins on the left edge of the tongue. Then insertion of the blocker and tongue suture. The tumor is now excised with the electric needle with a safety margin of at least 0.5 cm and a depth of 1 cm in the muscular area. This creates a relatively large wound area. Intermediate bipolar hemostasis. This resectate is then thread-marked for final histology. Now take marginal samples, on the one hand from the anterior and posterior tongue surface with respective suture marking and on the lower surface at the transition to the floor of the mouth in one piece and in triplicate from the wound bed anteriorly, medially and posteriorly. The samples are all classified as tumor-free in the frozen section. Therefore, bipolar hemostasis and insertion of a Tranexam-soaked compress. Transition to neck dissection on the left side. Placement of facial nerve monitoring. Abjoration and sterile draping. The skin incision is made in a skin fold approx. 2 cm from the mandible and is curved slightly upwards posteriorly and also curved slightly submentally anteriorly in order to access level Ia. Dissection through the subcutaneous tissue and through the platysma. The platysma flap is then formed cranially and caudally. Cranially to just below the marginal ramus, which can be detected with stimulation. Then dissect the sternocleidomastoid muscle as well as the digaster venter anterior muscle and omohyoid muscle. Exposure and protection of the accessorius nerve. Protection of the cervical profunda. Protection of the marginal ramus. Dissection of the internal jugular vein and the facial vein, all of which are preserved. Subsequent dissection of level II b and the lateral compartment. Subsequent dissection of the anterior neck compartment. Now expose the submandibular gland and move it upwards. The marginal ramus is spared up to the anterior. It can still be stimulated proximally at the end of the operation. Exposure of the mylohyoid muscle and the digaster venter muscle anteriorly on both sides. Clearing of level I b and I a. Protection of the hypoglossal nerve. Subsequent subtle hemostasis with H2O2 and Ringer and bipolar coagulation. Placement of a 10 Redon drain, subcutaneous and platysma suture with 4-0 Vicryl and skin suture with 5-0 Ethilon. Subsequent final enoral check. The wound edges are slightly adapted posteriorly and anteriorly with 2 Vicryl 3-0 SH sutures. A relatively large wound area remains. Repeated subtle bipolar hemostasis and completion of the operation at this point without complications. Conclusion: Enormous tumor resection in cT1 cN0 tongue margin carcinoma on the left, tumor-free in the frozen section. Neck dissection level I a to IV left. \ No newline at end of file diff --git a/558/InvasionFront_CD3_block4_x1_y5_patient558_0.json b/558/InvasionFront_CD3_block4_x1_y5_patient558_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f6f52aabcf20b140f79f40d10590d932f8afe88 --- /dev/null +++ b/558/InvasionFront_CD3_block4_x1_y5_patient558_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6621.5, + "Centroid Y µm": 18515.2, + "Num Detections": 19520, + "Num Negative": 18461, + "Num Positive": 1059, + "Positive %": 5.425, + "Num Positive per mm^2": 483.18 + } +} \ No newline at end of file diff --git a/558/InvasionFront_CD3_block4_x2_y5_patient558_1.json b/558/InvasionFront_CD3_block4_x2_y5_patient558_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f61456a0a49dbda86fd4f0397b697d004be746c --- /dev/null +++ b/558/InvasionFront_CD3_block4_x2_y5_patient558_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9220.1, + "Centroid Y µm": 18490.2, + "Num Detections": 14385, + "Num Negative": 14357, + "Num Positive": 28, + "Positive %": 0.1946, + "Num Positive per mm^2": 16.34 + } +} \ No newline at end of file diff --git a/558/InvasionFront_CD8_block4_x1_y5_patient558_0.json b/558/InvasionFront_CD8_block4_x1_y5_patient558_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dd9514cedeb1283a6fdbb1c7b4808c2164180bf4 --- /dev/null +++ b/558/InvasionFront_CD8_block4_x1_y5_patient558_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 17265.9, + "Num Detections": 19280, + "Num Negative": 17964, + "Num Positive": 1316, + "Positive %": 6.826, + "Num Positive per mm^2": 603.11 + } +} \ No newline at end of file diff --git a/558/InvasionFront_CD8_block4_x2_y5_patient558_1.json b/558/InvasionFront_CD8_block4_x2_y5_patient558_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0a6af79e8e8dac5507d0e6ce07352cac651e7b0d --- /dev/null +++ b/558/InvasionFront_CD8_block4_x2_y5_patient558_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 17340.8, + "Num Detections": 13543, + "Num Negative": 13493, + "Num Positive": 50, + "Positive %": 0.3692, + "Num Positive per mm^2": 27.91 + } +} \ No newline at end of file diff --git a/558/TumorCenter_CD3_block4_x1_y5_patient558_0.json b/558/TumorCenter_CD3_block4_x1_y5_patient558_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b97f7347dea6f713ab6cf8c30e900ca70ea5b994 --- /dev/null +++ b/558/TumorCenter_CD3_block4_x1_y5_patient558_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3498.1, + "Centroid Y µm": 12843.2, + "Num Detections": 19250, + "Num Negative": 18341, + "Num Positive": 909, + "Positive %": 4.722, + "Num Positive per mm^2": 409.46 + } +} \ No newline at end of file diff --git a/558/TumorCenter_CD3_block4_x2_y5_patient558_1.json b/558/TumorCenter_CD3_block4_x2_y5_patient558_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c1e555d27ddc13b4c83c058f0ca26602c0310d3b --- /dev/null +++ b/558/TumorCenter_CD3_block4_x2_y5_patient558_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 12893.2, + "Num Detections": 17745, + "Num Negative": 16871, + "Num Positive": 874, + "Positive %": 4.925, + "Num Positive per mm^2": 439.11 + } +} \ No newline at end of file diff --git a/558/TumorCenter_CD8_block4_x1_y5_patient558_0.json b/558/TumorCenter_CD8_block4_x1_y5_patient558_0.json new file mode 100644 index 0000000000000000000000000000000000000000..21a67d4e954c7d179c3964f1e242cecd7c8d2439 --- /dev/null +++ b/558/TumorCenter_CD8_block4_x1_y5_patient558_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4372.7, + "Centroid Y µm": 12243.5, + "Num Detections": 16195, + "Num Negative": 15570, + "Num Positive": 625, + "Positive %": 3.859, + "Num Positive per mm^2": 344.78 + } +} \ No newline at end of file diff --git a/558/TumorCenter_CD8_block4_x2_y5_patient558_1.json b/558/TumorCenter_CD8_block4_x2_y5_patient558_1.json new file mode 100644 index 0000000000000000000000000000000000000000..78818dd5809e56aaa7c2a67d5e23cbd9325d683b --- /dev/null +++ b/558/TumorCenter_CD8_block4_x2_y5_patient558_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7146.2, + "Centroid Y µm": 12543.4, + "Num Detections": 12545, + "Num Negative": 12343, + "Num Positive": 202, + "Positive %": 1.61, + "Num Positive per mm^2": 151.52 + } +} \ No newline at end of file diff --git a/558/history_text.txt b/558/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..132746c1a3b9d6331d9e2e4aa29eeda9d520a538 --- /dev/null +++ b/558/history_text.txt @@ -0,0 +1 @@ +Sonographic cN0 neck after histologic PEC confirmation. Decision of the interdisciplinary tumor conference for tumor resection using TORS and ND on the right. \ No newline at end of file diff --git a/558/icd_codes.txt b/558/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..faeaea441ea3ffed1b2bd4c4310dfc9d7abb02d0 --- /dev/null +++ b/558/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Fossa tonsillaris[C09.0 ] \ No newline at end of file diff --git a/558/ops_codes.txt b/558/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..88387aa66fc922967920e0ff17db44403f9814ed --- /dev/null +++ b/558/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit lokaler Schleimhaut[5-296.01 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/558/patient_clinical_data.json b/558/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4466dddcb9916e5faf08270fc95ed3e89df51dd3 --- /dev/null +++ b/558/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/558/patient_pathological_data.json b/558/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8165a84943c774eaab40ea8e81bdbd4db4efb456 --- /dev/null +++ b/558/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "558", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 28, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/558/surgery_description.txt b/558/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..82efbb6371ff7fec8ad0a6182410d41489990d8c --- /dev/null +++ b/558/surgery_description.txt @@ -0,0 +1 @@ +TORS und Neck dissektion diff --git a/558/surgery_report.txt b/558/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e0fbd1cda6d9b3aad4ccb7fddd5983234271673a --- /dev/null +++ b/558/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, the surgeon first positions the patient's head for endoscopic inspection using a C-tube after insertion of a mouth guard, in which the slightly exophytic mass is seen as described above on the right anterior palatal arch over the lower pole of the tonsil with transition to the base of the tongue on the right; no transition in the middle or to the left and no deep infiltration on palpation. Other findings were also identical to the panendoscopy. Initial positioning of the tumor with the LARS retractor, which was successful, and insertion of an epipharyngeal abutment. Enormous positioning of the camera arm and the 5 mm arms with setting up of all cannula remote centers before insertion of the collision-free instruments. Now start dissection at the cranial beginning of the tumor in the area of the anterior right palatal arch using Maryland Dissector (left arm) and Monopolar (right arm) and gradual tangential dissection caudally with sufficient safety distance. Intermittent hemostasis using a monopolar and at the caudal tonsil pole using a vascular clip with a pulsating artery. Finally, marginal samples on the right anterior palatal arch, right anterior base of the tongue, middle base of the tongue and posterior base of the tongue, which are free of tumors on all sides in the frozen section. Final check without evidence of bleeding. Positioning for neck dissection on the right. Infiltration with a total of 8 ml Ultracaine 2% Suprarenin (0.006 mg/ml) in the area of the planned skin incision at the anterior border of the MSCM. Abjode and cover the adjacent areas. Skin incision on the anterior border of the sternocleidomastoid muscle. Separation of the skin and platysma, ligation of the external jugular vein, exposure of the anterior edge of the sternocleidomastoid muscle. Finding the internal jugular vein. Dissection of the omohyoid muscle and exposure of the posterior venter of the digastric muscle, as well as exposure of the accessorius nerve. Insertion of the retractors and preparation of the internal jugular vein for the posterior neck preparation. Exposure of the cervical vascular sheath with vagus nerve, internal jugular vein, vagus nerve, common carotid artery and later the hypoglossal nerve. Then clear out the entire posterior neck preparation, sparing the accessorius nerve and the entire cervical plexus, as well as the above-mentioned structures. Now dissect anteriorly to expose the hypoglossal nerve and complete the anterior neck preparation. No pathological lymph nodes can be seen macroscopically in the preparation. Finally, localized hemostasis with bipolar and insertion of a 10-gauge Redon drain on the right, then two-layer wound closure. The procedure was completed without complications. Conclusion: R0 tumor resection (TORS) of a cT2 cN0 tonsil-tongue base cancer on the right and selective neck dissection on the right level II-Va. Procedure: Re-presentation for discussion of the histologic findings and presentation of TUKO with question of adjuvant therapy, possibly PEG placement. \ No newline at end of file diff --git a/559/InvasionFront_CD3_block1_x3_y5_patient559_0.json b/559/InvasionFront_CD3_block1_x3_y5_patient559_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a48281951b9a62268f4f154e8a971d7781ada770 --- /dev/null +++ b/559/InvasionFront_CD3_block1_x3_y5_patient559_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11543.9, + "Centroid Y µm": 14267.4, + "Num Detections": 13912, + "Num Negative": 13491, + "Num Positive": 421, + "Positive %": 3.026, + "Num Positive per mm^2": 228.72 + } +} \ No newline at end of file diff --git a/559/InvasionFront_CD3_block1_x4_y5_patient559_1.json b/559/InvasionFront_CD3_block1_x4_y5_patient559_1.json new file mode 100644 index 0000000000000000000000000000000000000000..154e72213c8561aa95332bbb1f6739969db1e83b --- /dev/null +++ b/559/InvasionFront_CD3_block1_x4_y5_patient559_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14117.5, + "Centroid Y µm": 14367.4, + "Num Detections": 20995, + "Num Negative": 20645, + "Num Positive": 350, + "Positive %": 1.667, + "Num Positive per mm^2": 138.61 + } +} \ No newline at end of file diff --git a/559/InvasionFront_CD8_block1_x3_y5_patient559_0.json b/559/InvasionFront_CD8_block1_x3_y5_patient559_0.json new file mode 100644 index 0000000000000000000000000000000000000000..46fc14d236c4b682edb841b20080c640db63cc91 --- /dev/null +++ b/559/InvasionFront_CD8_block1_x3_y5_patient559_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11643.8, + "Centroid Y µm": 12793.2, + "Num Detections": 12252, + "Num Negative": 11914, + "Num Positive": 338, + "Positive %": 2.759, + "Num Positive per mm^2": 209.97 + } +} \ No newline at end of file diff --git a/559/InvasionFront_CD8_block1_x4_y5_patient559_1.json b/559/InvasionFront_CD8_block1_x4_y5_patient559_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1084681b5bb569c4cc43a30d640e70c4a19afa99 --- /dev/null +++ b/559/InvasionFront_CD8_block1_x4_y5_patient559_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 13043.1, + "Num Detections": 19766, + "Num Negative": 19408, + "Num Positive": 358, + "Positive %": 1.811, + "Num Positive per mm^2": 144.96 + } +} \ No newline at end of file diff --git a/559/TumorCenter_CD3_block1_x3_y7_patient559_0.json b/559/TumorCenter_CD3_block1_x3_y7_patient559_0.json new file mode 100644 index 0000000000000000000000000000000000000000..222610018aec6eac98134f073c407da61d293b75 --- /dev/null +++ b/559/TumorCenter_CD3_block1_x3_y7_patient559_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10719.3, + "Centroid Y µm": 17740.6, + "Num Detections": 4919, + "Num Negative": 4596, + "Num Positive": 323, + "Positive %": 6.566, + "Num Positive per mm^2": 496.69 + } +} \ No newline at end of file diff --git a/559/TumorCenter_CD3_block1_x4_y7_patient559_1.json b/559/TumorCenter_CD3_block1_x4_y7_patient559_1.json new file mode 100644 index 0000000000000000000000000000000000000000..84c3b3820613eaaa3c756bfb406097b72dedcaa6 --- /dev/null +++ b/559/TumorCenter_CD3_block1_x4_y7_patient559_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13342.9, + "Centroid Y µm": 17565.7, + "Num Detections": 12427, + "Num Negative": 11970, + "Num Positive": 457, + "Positive %": 3.677, + "Num Positive per mm^2": 263.97 + } +} \ No newline at end of file diff --git a/559/TumorCenter_CD8_block1_x3_y5_patient559_0.json b/559/TumorCenter_CD8_block1_x3_y5_patient559_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b7b5a9d1fd1fbb12ddce5606457600246593fd42 --- /dev/null +++ b/559/TumorCenter_CD8_block1_x3_y5_patient559_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 21338.7, + "Num Detections": 24684, + "Num Negative": 17182, + "Num Positive": 7502, + "Positive %": 30.39, + "Num Positive per mm^2": 2801.6 + } +} \ No newline at end of file diff --git a/559/TumorCenter_CD8_block1_x4_y5_patient559_1.json b/559/TumorCenter_CD8_block1_x4_y5_patient559_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0576fd1ff1e773840d39d30a775536ab2d47eea0 --- /dev/null +++ b/559/TumorCenter_CD8_block1_x4_y5_patient559_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 21313.7, + "Num Detections": 27150, + "Num Negative": 21776, + "Num Positive": 5374, + "Positive %": 19.79, + "Num Positive per mm^2": 2008.6 + } +} \ No newline at end of file diff --git a/559/history_text.txt b/559/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/559/icd_codes.txt b/559/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adab28f0b88ba31c5bb4895a3d4f3034f2967b3e --- /dev/null +++ b/559/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] \ No newline at end of file diff --git a/559/ops_codes.txt b/559/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3aeb274fe276b4bc6e945f2e90ae6080158d1c6c --- /dev/null +++ b/559/ops_codes.txt @@ -0,0 +1 @@ +Plastische Korrektur des Nasenseptums mit Resektion[5-214.6 ] Sonstige Operation mehrere Nasennebenhöhlen[5-224.x R] Operationen an der Kieferhöhle, endonasal[5-221.6 R] Permanente Tracheotomie[5-312.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 R] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme freier Radialis-Lappen[5-858.23 L] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Transplantat[5-296.14 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] \ No newline at end of file diff --git a/559/patient_clinical_data.json b/559/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..85e43f75dfa492d7a03c7fb0165ba529e2a9b976 --- /dev/null +++ b/559/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/559/patient_pathological_data.json b/559/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..25870c484bd5563f60f937d6b2f589922b1bb277 --- /dev/null +++ b/559/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "559", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 18.0 +} \ No newline at end of file diff --git a/559/surgery_description.txt b/559/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2f9a4814678b111c0aaa196a0dcf4d23494d896e --- /dev/null +++ b/559/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion, sel. Neck diss. bds., Defektdeckung, Freier Lappen (Radialis), Tracheostoma, PEG-Anlage diff --git a/559/surgery_report.txt b/559/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7701ad8264d0a93601b25d1526697ea8bdc40b41 --- /dev/null +++ b/559/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, the septum and paranasal sinus surgery is performed first. After shortening the vibrissae, hemitransfixion incision on the right and creation of the upper and lower tunnel according to Cottle on the left side. Vertical chondrotomy. Creation of the upper and lower tunnel on the right side. This allows the cartilaginous bony spur, which has deviated markedly to the right, to be adequately exposed and resected. This results in a slit-shaped mucus defect. The middle nasal passage is then exposed by carefully medializing the middle turbinate without fracturing it. Removal of the uncinate process. Creation of a large maxillary sinus window, from which inflammatory swollen mucosa emerges from the ostium. Subsequent clearing of the maxillary sinus with macroscopically typical aspects of fungal sinusitis. Subsequently, extensive rinsing of the maxillary sinus after maximum expansion of the supraturbinal maxillary sinus window. Subsequently, replantation of crushed pieces of cartilage and bone between the dorsal septal mucosal sheets. Fixation of the anterior septal pillar to the anterior nasal spine using sutures. Suturing of the right hemitransfixion incision. Placement and transseptal fixation of septal foils on both sides. Nasal tamponade on both sides, which is mutually fixed in front of the columella. The tracheostomy is then performed. After a skin incision about 2 QF above the jugulum, sharp transection of the cutis, subcutis and subcutaneous fatty tissue with exposure of the linea alba. Dissect the straight neck muscles along the linea alba and expose the thyroid isthmus. Passing under the lamina pretrachealis, pinching off, setting down and repositioning on both sides. This clearly shows the 4 upper tracheal clips. Opening of the trachea between the 2nd and 3rd tracheal clasp and completion of the mucocutaneous anastomosis. Easy reintubation of the patient after tube removal. PEG placement (, ). Entry with the gastroesophagoscope under air insufflation. Pre-insufflation into the stomach. After spontaneous diaphanoscopy, insertion of a PEG in the typical manner using the thread pull-through method. Prior to this, perioperative administration of Unacid 3 g. Subsequently, transition to transoral tumor resection. After insertion of the tonsillar blocker with the mouth opening clearly restricted, the entire right tonsil, especially in the caudal area, is resected successively with the ultrasonic knife. The resection begins at the upper tonsil pole parauvularly and encompasses the entire tonsil lobe. The resection is performed caudally along the ascending mandibular branch with a remaining gingiva of about 2-3 mm opposite the molars. Here it becomes clear that the tumor cannot be safely removed from above, especially in the caudal region towards the base of the tongue and the glossotonsillar groove. Therefore, the neck dissection is first performed on the right side. Here, the vascular nerve sheath is exposed after a skin incision. After exposing and dissecting the digastric muscle, the large cystic metastasis is developed from medial to lateral together with the neck dissection specimen. All non-lymphatic structures are spared. After exposing and skeletonizing the accessorius nerve, regions II to V are then completely removed. The submandibular gland and region I are then removed. Dissection of the digastric muscle. This already reveals the defect enorally. The lingual nerve is exposed and can be spared until the end, as can the hypoglossal nerve. After slight widening, the cranially already resected tumor can be moved outwards and the caudal area in the area of the glossotonsillar groove or base of the tongue can finally be removed in toto under visualization. The frozen section histological examination of the specimen shows tumor-free margins on all sides. The minimum distance to the depth is 0.3 cm. For this reason, the remaining tissue on the external carotid artery in the area of the deep margin is also removed retrospectively so that the vascular nerve sheath is exposed cranially and all tissue is removed. This results in a defect measuring approximately 9 x 5 cm. Removal of the radial elevation of the radial forearm flap on the left (, , PJ): Palpatory identification of the distal radial artery, marking of the flap borders 9.5 x 7.5 cm on the distal forearm proximal to the flexor retinaculum with S-shaped course on the incision proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the stenosis confluence in the cubital fossa, identification of the cephalic vein. Dissection of the vein distally with integration into the radial flap graft edge. Identification of the external ramus of the radial nerve and elevation of the radial portion while leaving the peritendinous tissue of the brachioradialis muscle. Subsequent ulnar incision down to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendinous tissue on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and probatory clamping with a vascular clamp after 5 minutes under good pulse oximetry measured oxygen saturation, measured on the thumb, the vessels are removed with subsequent lateral thread ligation. Successive detachment of the flap pedicle from the pronator quadratus and flexor pollicis longus muscles and bipolar coagulation of the outgoing perforators as well as supply with a vessel clip into the cubital fossa. Exposure and protection of the radial nerve in the median side of the brachioradialis muscle. Exposure of the brachial artery and the ulnar artery. There is no V. mediana cubiti, only a V. cephalica. First, the radial artery and the 2 accompanying veins are dissected so that they can be connected later and the cephalic vein is cut very far proximally for connection to the jugular vein, later. After exposing the ulnar, brachial and radial arteries, the radial artery is removed while sparing all other vessels. Punctual hemostasis in the area of the wound bed with bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm and the graft bed with split skin from the right thigh in the usual manner. The split skin was previously divided three times and lifted. Application of a wound dressing and forearm splint. Completion without complications. Continuation of the operation on the neck with neck dissection of regions II to V on the left side. After insertion of a Redon suction drain, two-layer wound closure. The lifted radialis flap is then sutured into the defect, initially from the transcervical and in the cranial region from the transoval side, and the pedicle is passed outwards. The arterial anastomosis is made to the facial artery, while the venous anastomoses are connected to the internal jugular vein with 2 veins of the flap in an end-to-side manner. After hemostasis, placement of a drain and a Redon suction drain. Two-layer wound closure. Re-intubation of the patient onto an 8-gauge tracheostomy tube. Stable wound dressing. End of the operation. Conclusion: Initially plastic septal correction for septal deviation and ethmoid bone and maxillary sinus surgery on the right side for fungal sinusitis of the right maxillary sinus. Subsequently, combined transoral-transcervical tumor resection of a tonsillar carcinoma on the right side with selective neck dissection of regions I to V on the right and II to V on the left side. Defect coverage with a microvascular anastomosed radial artery flap graft from the left forearm. Arterial anastomosis to the facial artery, venous anastomosis of 2 veins end-to-side to the internal jugular vein on the right side, creation of a plastic tracheostoma, PEG creation, defect coverage on the left forearm with split skin from the right thigh. \ No newline at end of file diff --git a/560/InvasionFront_CD3_block15_x5_y5_patient560_0.json b/560/InvasionFront_CD3_block15_x5_y5_patient560_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ed1a21262e2ec866ce156d378bf4fff040b7b36 --- /dev/null +++ b/560/InvasionFront_CD3_block15_x5_y5_patient560_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18165.4, + "Centroid Y µm": 22338.2, + "Num Detections": 13889, + "Num Negative": 13770, + "Num Positive": 119, + "Positive %": 0.8568, + "Num Positive per mm^2": 60.86 + } +} \ No newline at end of file diff --git a/560/InvasionFront_CD3_block15_x6_y5_patient560_1.json b/560/InvasionFront_CD3_block15_x6_y5_patient560_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ae4dbc6f87c5df7a846b9e85f21333a353050e2f --- /dev/null +++ b/560/InvasionFront_CD3_block15_x6_y5_patient560_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20764.0, + "Centroid Y µm": 22163.3, + "Num Detections": 15250, + "Num Negative": 14578, + "Num Positive": 672, + "Positive %": 4.407, + "Num Positive per mm^2": 315.31 + } +} \ No newline at end of file diff --git a/560/InvasionFront_CD8_block15_x5_y5_patient560_0.json b/560/InvasionFront_CD8_block15_x5_y5_patient560_0.json new file mode 100644 index 0000000000000000000000000000000000000000..793824e660affa182f1c273c893a90ab52148057 --- /dev/null +++ b/560/InvasionFront_CD8_block15_x5_y5_patient560_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16249.2, + "Centroid Y µm": 12067.6, + "Num Detections": 9484, + "Num Negative": 9446, + "Num Positive": 38, + "Positive %": 0.4007, + "Num Positive per mm^2": 31.01 + } +} \ No newline at end of file diff --git a/560/InvasionFront_CD8_block15_x6_y5_patient560_1.json b/560/InvasionFront_CD8_block15_x6_y5_patient560_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ccb075f448a9245b1c26085d31a869da7ab3f8cc --- /dev/null +++ b/560/InvasionFront_CD8_block15_x6_y5_patient560_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18853.6, + "Centroid Y µm": 12220.0, + "Num Detections": 9253, + "Num Negative": 9040, + "Num Positive": 213, + "Positive %": 2.302, + "Num Positive per mm^2": 189.71 + } +} \ No newline at end of file diff --git a/560/TumorCenter_CD3_block15_x5_y5_patient560_0.json b/560/TumorCenter_CD3_block15_x5_y5_patient560_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dbad6ef06af67e414f41180d9b5678b7c341e023 --- /dev/null +++ b/560/TumorCenter_CD3_block15_x5_y5_patient560_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 15841.6, + "Num Detections": 22111, + "Num Negative": 17919, + "Num Positive": 4192, + "Positive %": 18.96, + "Num Positive per mm^2": 1641.9 + } +} \ No newline at end of file diff --git a/560/TumorCenter_CD3_block15_x6_y5_patient560_1.json b/560/TumorCenter_CD3_block15_x6_y5_patient560_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e0cd07d635a495fe4f2b8d859e9af3087f6a5c69 --- /dev/null +++ b/560/TumorCenter_CD3_block15_x6_y5_patient560_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 15841.6, + "Num Detections": 24930, + "Num Negative": 19647, + "Num Positive": 5283, + "Positive %": 21.19, + "Num Positive per mm^2": 2058.5 + } +} \ No newline at end of file diff --git a/560/TumorCenter_CD8_block15_x5_y5_patient560_0.json b/560/TumorCenter_CD8_block15_x5_y5_patient560_0.json new file mode 100644 index 0000000000000000000000000000000000000000..13e41231ed67d170ededb4aabc76ab239a6d5486 --- /dev/null +++ b/560/TumorCenter_CD8_block15_x5_y5_patient560_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 12418.4, + "Num Detections": 20672, + "Num Negative": 13521, + "Num Positive": 7151, + "Positive %": 34.59, + "Num Positive per mm^2": 2820.7 + } +} \ No newline at end of file diff --git a/560/TumorCenter_CD8_block15_x6_y5_patient560_1.json b/560/TumorCenter_CD8_block15_x6_y5_patient560_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d56cba71164365ca7c82aba856798320bf509235 --- /dev/null +++ b/560/TumorCenter_CD8_block15_x6_y5_patient560_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21513.6, + "Centroid Y µm": 12368.5, + "Num Detections": 21950, + "Num Negative": 9904, + "Num Positive": 12046, + "Positive %": 54.88, + "Num Positive per mm^2": 4696.5 + } +} \ No newline at end of file diff --git a/560/history_text.txt b/560/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/560/icd_codes.txt b/560/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/560/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/560/ops_codes.txt b/560/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..84cffd0a142c12abd8004aecd2b3682abb9cdcd4 --- /dev/null +++ b/560/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Exzision[5-250.2 ] \ No newline at end of file diff --git a/560/patient_clinical_data.json b/560/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..246f307fbd391f106327e0f4a2a6be82aa649a72 --- /dev/null +++ b/560/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2008, + "age_at_initial_diagnosis": 72, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/560/patient_pathological_data.json b/560/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..07324b5135f10858efafa43fb68f0265551cbd73 --- /dev/null +++ b/560/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "560", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 21, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/560/surgery_description.txt b/560/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3190b555600b001f58841b3088b4603b9ffb4bf5 --- /dev/null +++ b/560/surgery_description.txt @@ -0,0 +1 @@ +Exzision Tumor i.B. Zungenrand rechts, Panendo diff --git a/560/surgery_report.txt b/560/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8a200cd2ede1b492e3ef0c0d8220c247813396fc --- /dev/null +++ b/560/surgery_report.txt @@ -0,0 +1 @@ +First tracheoscopy: Entering the cervical trachea with the 0° straight tracheoscope. No evidence of exophytic tumor growth. Subsequent intubation. Now perform esophagogastroscopy. Enter the stomach through the esophagus with the flexible gastroscope. The stomach shows a partially lifted gastric fold. No evidence of exophytic tumor growth. Retraction of the esophagoscope, no evidence of exophytic tumor growth in the esophagus. Now inspection of the hypopharynx and the piriform sinus on the right and left: No evidence of exophytic tumor growth. Now inspection of the larynx, lingual, laryngeal epiglottis, anterior commissure, posterior commissure, left and right vocal fold macroscopically unremarkable. Postcricoid region macroscopically unremarkable. Now inspection of the oral cavity. The previously described mass at the edge of the tongue is now visible on the right. Now place a holding suture, elevate the tongue to the left, cut around the mass in a circular fashion and extirpate it in toto. Samples are taken from the edges of the specimen in a clockwise direction and sent for processing. Marking of the remaining surgical specimen. Careful hemostasis is then performed again. Suturing of the wound edges. Ultrasound on <2008> showed several small lymph nodes up to 12 mm in diameter and hilar signs in the right tongue after PE. On the advice of , a right neck dissection is currently being avoided. After receiving the definitive histology, a decision will be made about a right neck dissection. Conclusion: Panendoscopy and excision of a right tongue margin tumor. \ No newline at end of file diff --git a/561/InvasionFront_CD3_block3_x1_y5_patient561_0.json b/561/InvasionFront_CD3_block3_x1_y5_patient561_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bd2add0d3d292b5b7d6a922745157f6aa0b03a27 --- /dev/null +++ b/561/InvasionFront_CD3_block3_x1_y5_patient561_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5497.1, + "Centroid Y µm": 16916.0, + "Num Detections": 22219, + "Num Negative": 22028, + "Num Positive": 191, + "Positive %": 0.8596, + "Num Positive per mm^2": 84.12 + } +} \ No newline at end of file diff --git a/561/InvasionFront_CD3_block3_x2_y5_patient561_1.json b/561/InvasionFront_CD3_block3_x2_y5_patient561_1.json new file mode 100644 index 0000000000000000000000000000000000000000..addffe0c8579873aebb332218d5c3e38157c3fbc --- /dev/null +++ b/561/InvasionFront_CD3_block3_x2_y5_patient561_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7995.8, + "Centroid Y µm": 17140.9, + "Num Detections": 22420, + "Num Negative": 22261, + "Num Positive": 159, + "Positive %": 0.7092, + "Num Positive per mm^2": 73.91 + } +} \ No newline at end of file diff --git a/561/InvasionFront_CD8_block3_x1_y5_patient561_0.json b/561/InvasionFront_CD8_block3_x1_y5_patient561_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f37f0548f165f97884e3c7d0553f32ffaabb0aa3 --- /dev/null +++ b/561/InvasionFront_CD8_block3_x1_y5_patient561_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5217.7, + "Centroid Y µm": 12320.6, + "Num Detections": 15204, + "Num Negative": 14873, + "Num Positive": 331, + "Positive %": 2.177, + "Num Positive per mm^2": 193.06 + } +} \ No newline at end of file diff --git a/561/InvasionFront_CD8_block3_x2_y5_patient561_1.json b/561/InvasionFront_CD8_block3_x2_y5_patient561_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc1a20317e9d7fc8e98623031c09ac3154ee94a0 --- /dev/null +++ b/561/InvasionFront_CD8_block3_x2_y5_patient561_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7694.0, + "Centroid Y µm": 12307.1, + "Num Detections": 19763, + "Num Negative": 19738, + "Num Positive": 25, + "Positive %": 0.1265, + "Num Positive per mm^2": 11.68 + } +} \ No newline at end of file diff --git a/561/TumorCenter_CD3_block3_x1_y5_patient561_0.json b/561/TumorCenter_CD3_block3_x1_y5_patient561_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c02fa9cd7d5c58bb621ca7993d985cf35105d251 --- /dev/null +++ b/561/TumorCenter_CD3_block3_x1_y5_patient561_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 18715.1, + "Num Detections": 17566, + "Num Negative": 16800, + "Num Positive": 766, + "Positive %": 4.361, + "Num Positive per mm^2": 379.74 + } +} \ No newline at end of file diff --git a/561/TumorCenter_CD3_block3_x2_y5_patient561_1.json b/561/TumorCenter_CD3_block3_x2_y5_patient561_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c837c40b2c626a2f15deb31c79b34c05ed0c9fff --- /dev/null +++ b/561/TumorCenter_CD3_block3_x2_y5_patient561_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6192.5, + "Centroid Y µm": 18677.2, + "Num Detections": 2159, + "Num Negative": 2127, + "Num Positive": 32, + "Positive %": 1.482, + "Num Positive per mm^2": 112.54 + } +} \ No newline at end of file diff --git a/561/TumorCenter_CD8_block3_x1_y5_patient561_0.json b/561/TumorCenter_CD8_block3_x1_y5_patient561_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e8b1dab2166e302bcb89e3befdcc813628363279 --- /dev/null +++ b/561/TumorCenter_CD8_block3_x1_y5_patient561_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4572.6, + "Centroid Y µm": 13467.9, + "Num Detections": 26081, + "Num Negative": 25884, + "Num Positive": 197, + "Positive %": 0.7553, + "Num Positive per mm^2": 78.15 + } +} \ No newline at end of file diff --git a/561/TumorCenter_CD8_block3_x2_y5_patient561_1.json b/561/TumorCenter_CD8_block3_x2_y5_patient561_1.json new file mode 100644 index 0000000000000000000000000000000000000000..756e50f8027d0a2f3fe3b6e5a2b89a05457a8b4e --- /dev/null +++ b/561/TumorCenter_CD8_block3_x2_y5_patient561_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7121.2, + "Centroid Y µm": 13592.8, + "Num Detections": 22248, + "Num Negative": 22113, + "Num Positive": 135, + "Positive %": 0.6068, + "Num Positive per mm^2": 60.43 + } +} \ No newline at end of file diff --git a/561/history_text.txt b/561/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..721c64cd6e6357b465b739c6f9dc0f175b30965c --- /dev/null +++ b/561/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed T1 tonsillar carcinoma on the left side, which is why the above-mentioned surgical indication was given. \ No newline at end of file diff --git a/561/icd_codes.txt b/561/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f9510bbee56cb9c8627540be72492645e1bf7c77 --- /dev/null +++ b/561/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Fossa tonsillaris[C09.0 L] Neubildung bösartig Halslymphknoten[C77.0 L] \ No newline at end of file diff --git a/561/ops_codes.txt b/561/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8885de224bf15273f3089d25c9fe8d31de44dd5d --- /dev/null +++ b/561/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Transorale radikale Resektion des Pharynx mit Rekonstruktion mit lokaler Schleimhaut[5-296.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Anwendung eines komplexen OP-Roboters (Zusatzkode)[5-987.0 ] \ No newline at end of file diff --git a/561/patient_clinical_data.json b/561/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e60057e6585956b5f5b175a06c4762c7c665d720 --- /dev/null +++ b/561/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 77, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/561/patient_pathological_data.json b/561/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..46d856a5f22d5ce89c28d6bf2eed292831b09c78 --- /dev/null +++ b/561/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "561", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 14, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/561/surgery_description.txt b/561/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5f6d9b640adf40d7cfe6026aa446d9139ba21e2f --- /dev/null +++ b/561/surgery_description.txt @@ -0,0 +1 @@ +TORS: Tonsillektomie, Neck dissection diff --git a/561/surgery_report.txt b/561/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8fa09eecb37d68e64c5a0d6d13f6da0db10e5853 --- /dev/null +++ b/561/surgery_report.txt @@ -0,0 +1 @@ +After positioning the patient and inserting the TORS barrier and then docking the Da Vinci robot. Start by inspecting the tonsil. An exophytic mass can be seen in the area of the lower tonsil pole, which merges with the tonsil. The upper tonsil pole is far away from the tumor. Resection of the upper pole of the tonsil begins, which is shown here after preparation of the mucosa of the anterior palatal arch. The tonsil is then released from the upper pole. Dissection is performed down to the pharyngeal muscles. The tonsil is then dissected caudally along the pharyngeal muscles, sparing the posterior palatal arch as much as possible. The tumor is then revealed in the caudal part of the tonsil, so that the preparation plane must then also be moved to the posterior pharyngeal wall. The preparation is also performed at the level of the pharyngeal muscles. The dissection is then carried out up to the transition to the base of the tongue, where the tonsil is then placed far caudally from the tumor. Subsequent subtle hemostasis. Now take marginal samples from the ventral and dorsal as well as basal margin. All of these margin samples are found to be tumor-free in the frozen section intraoperatively. If the wound is dry, all instruments are removed and the surgical robot undocked. After repositioning the patient, injection of local anesthetic and adrenaline in the area of the left side of the neck on the front edge of the sternocleidomastoid muscle. Incision and layer-by-layer dissection in depth. Exposure and dissection of the platysma. Further layered dissection in depth and exposure of the anterior edge of the sternocleidomastoid muscle. Establish the resection margins at the level of the omohyoid muscle and cranially on the digaster muscle. Exposure and sparing of the accessorius nerve. A large metastasis is then seen in the area of the venous angle, which also completely fills the hypoglossal triangle. The neck is then dissected from the posterior edge of the submandibular gland into the hypoglossal triangle. The hypoglossal nerve is exposed and spared together with the cervical profunda. Dissection is then carried out from here via the vein in a lateral direction. In the depth of the hypoglossal triangle, a tiny perforation of the pharynx can be seen, which has occurred here due to the preparation. This perforation is then sutured over twice so that parts of the digaster muscle also cover the perforation well. The cervical vascular sheath is then dissected. Detachment of the lateral neck preparation together with the accessorius triangle while sparing all branches of the cervical plexus on the deep cervical fascia. Then remove the ventral neck preparation. Expose and protect the lymphatic duct in the caudal deposition area. Subsequent subtle hemostasis. The specimen is sent for histopathological examination. Insertion of a Redon drain and then two-layer wound closure. At the end of the procedure, a nasogastric feeding tube is inserted; the patient should be fed via this tube for 5 days postoperatively. The procedure was then completed and the patient was transferred to the ENT intensive care unit after the recovery phase. \ No newline at end of file diff --git a/562/InvasionFront_CD3_block6_x5_y3_patient562_0.json b/562/InvasionFront_CD3_block6_x5_y3_patient562_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f2376367dbf325cf5960ee58efe19e39391e746 --- /dev/null +++ b/562/InvasionFront_CD3_block6_x5_y3_patient562_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17790.6, + "Centroid Y µm": 8245.6, + "Num Detections": 24589, + "Num Negative": 24027, + "Num Positive": 562, + "Positive %": 2.286, + "Num Positive per mm^2": 219.77 + } +} \ No newline at end of file diff --git a/562/InvasionFront_CD3_block6_x6_y3_patient562_1.json b/562/InvasionFront_CD3_block6_x6_y3_patient562_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8dda9dcc5f9792dedb61bd90d86e9b890111d5f7 --- /dev/null +++ b/562/InvasionFront_CD3_block6_x6_y3_patient562_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20264.3, + "Centroid Y µm": 8395.6, + "Num Detections": 20543, + "Num Negative": 19624, + "Num Positive": 919, + "Positive %": 4.474, + "Num Positive per mm^2": 380.18 + } +} \ No newline at end of file diff --git a/562/InvasionFront_CD8_block6_x5_y1_patient562_0.json b/562/InvasionFront_CD8_block6_x5_y1_patient562_0.json new file mode 100644 index 0000000000000000000000000000000000000000..79896de20e6a0a462abcfb0592f71907ee7be88b --- /dev/null +++ b/562/InvasionFront_CD8_block6_x5_y1_patient562_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18165.4, + "Centroid Y µm": 2723.6, + "Num Detections": 6871, + "Num Negative": 6707, + "Num Positive": 164, + "Positive %": 2.387, + "Num Positive per mm^2": 172.31 + } +} \ No newline at end of file diff --git a/562/InvasionFront_CD8_block6_x6_y1_patient562_1.json b/562/InvasionFront_CD8_block6_x6_y1_patient562_1.json new file mode 100644 index 0000000000000000000000000000000000000000..717e99bf705b308ce563fc4521017f151620b2f9 --- /dev/null +++ b/562/InvasionFront_CD8_block6_x6_y1_patient562_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20664.1, + "Centroid Y µm": 2873.5, + "Num Detections": 12834, + "Num Negative": 12621, + "Num Positive": 213, + "Positive %": 1.66, + "Num Positive per mm^2": 137.18 + } +} \ No newline at end of file diff --git a/562/TumorCenter_CD3_block6_x5_y1_patient562_0.json b/562/TumorCenter_CD3_block6_x5_y1_patient562_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a9590afb00005ce8f08bbca4c69e8d04a55802f4 --- /dev/null +++ b/562/TumorCenter_CD3_block6_x5_y1_patient562_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 2423.7, + "Num Detections": 15417, + "Num Negative": 14156, + "Num Positive": 1261, + "Positive %": 8.179, + "Num Positive per mm^2": 661.27 + } +} \ No newline at end of file diff --git a/562/TumorCenter_CD3_block6_x6_y1_patient562_1.json b/562/TumorCenter_CD3_block6_x6_y1_patient562_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9f80dc2da5e8c53c58832bb7cea3450972193aba --- /dev/null +++ b/562/TumorCenter_CD3_block6_x6_y1_patient562_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18989.9, + "Centroid Y µm": 2573.6, + "Num Detections": 23074, + "Num Negative": 16353, + "Num Positive": 6721, + "Positive %": 29.13, + "Num Positive per mm^2": 2725.5 + } +} \ No newline at end of file diff --git a/562/TumorCenter_CD8_block6_x5_y1_patient562_0.json b/562/TumorCenter_CD8_block6_x5_y1_patient562_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08f35d5533bfe64fb76c925010f1820edc4b6027 --- /dev/null +++ b/562/TumorCenter_CD8_block6_x5_y1_patient562_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 2773.5, + "Num Detections": 22252, + "Num Negative": 21586, + "Num Positive": 666, + "Positive %": 2.993, + "Num Positive per mm^2": 292.27 + } +} \ No newline at end of file diff --git a/562/TumorCenter_CD8_block6_x6_y1_patient562_1.json b/562/TumorCenter_CD8_block6_x6_y1_patient562_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cc8bb117e543754f6e4669b00171d5a01c41ea4d --- /dev/null +++ b/562/TumorCenter_CD8_block6_x6_y1_patient562_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 2823.5, + "Num Detections": 25822, + "Num Negative": 23100, + "Num Positive": 2722, + "Positive %": 10.54, + "Num Positive per mm^2": 1103.0 + } +} \ No newline at end of file diff --git a/562/history_text.txt b/562/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..06ff196ec692086da3bd51612ce4a6a0e8540fb6 --- /dev/null +++ b/562/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed squamous cell carcinoma of the anterior palatal arch. A panendoscopy with exclusion of a second malignancy was already performed on <2019>. Mirror findings revealed a raised mucosa in the area of the left anterior palatal arch. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/562/icd_codes.txt b/562/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adc050c8f628f1e558c676f540ed678cb6876eb8 --- /dev/null +++ b/562/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/562/ops_codes.txt b/562/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c749439f8a9419f04b07df19f7cf5bf4c18a0184 --- /dev/null +++ b/562/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] \ No newline at end of file diff --git a/562/patient_clinical_data.json b/562/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0a43474c6affc204696b6d5eaebb3b9f9c2485bc --- /dev/null +++ b/562/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 41, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/562/patient_pathological_data.json b/562/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8544ea983099f5be78fc8c0cb4317fc6be8a5a35 --- /dev/null +++ b/562/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "562", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 23, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/562/surgery_description.txt b/562/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8bc804cd62a34ff96cf584919f0bba8da92098eb --- /dev/null +++ b/562/surgery_description.txt @@ -0,0 +1 @@ +Transorale Tumorexzision i.S.e. Part. Pharyngektomie diff --git a/562/surgery_report.txt b/562/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..400b9ec7ad1e23f9e03fe453c1dbbfcfea5b57dc --- /dev/null +++ b/562/surgery_report.txt @@ -0,0 +1 @@ +Demonstration of findings to . Positioning of the patient by the surgeon after nasal intubation. Insertion of the McIVOR oral spatula. The resection margins are defined by . A tumor tonsillectomy is performed, leaving out the uvula and the posterior palatal arch. The safety distance to the macroscopically visible change is one cm on all sides. A tumor tonsillectomy is then performed on the left side using cold instruments so as not to mask the edges of the deposit. Minor bleeding is treated with bipolar forceps. A large wound cavity is now created. The pharynx is intact. Parapharyngeal fat can only be detected in the upper third of the tonsil lobe. The specimen is sent for frozen section diagnosis and marginal samples are also sent for frozen section diagnosis. On arrival of the frozen section, microfocal margin-forming infiltrates are seen on the lateral pharyngeal wall, caudal to the area where fat is visible parapharyngeally. Demonstration of the findings on . The remaining lateral wall is now resected so that parapharyngeal fatty tissue is now visible up to the lower third of the tonsil lobe. The resection is sent in with suture marking close to the tumor and the procedure is completed for the time being. A further resection would require safe flap coverage. Waiting for the final histology and discussion of the findings in our tumor conference. Meticulous hemostasis beforehand. Relax the McIVOR blade for 2 minutes and clamp it again, no bleeding. A nasogastric tube was inserted and should remain in place for at least 5 days. Conclusion: It is at least a cT2 oropharyngeal carcinoma on the left side. Waiting for the final histology and discussion of the findings in our tumor conference. If the R0 resection is confirmed, a left neck dissection would be necessary in 3 weeks. If a subsequent resection were necessary, this would have to be planned with a radial flap. \ No newline at end of file diff --git a/563/InvasionFront_CD3_block7_x3_y4_patient563_0.json b/563/InvasionFront_CD3_block7_x3_y4_patient563_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a4258d2383c47253426cb16bf8f7112d0bb40fd0 --- /dev/null +++ b/563/InvasionFront_CD3_block7_x3_y4_patient563_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 9644.9, + "Num Detections": 18681, + "Num Negative": 16248, + "Num Positive": 2433, + "Positive %": 13.02, + "Num Positive per mm^2": 1032.9 + } +} \ No newline at end of file diff --git a/563/InvasionFront_CD3_block7_x4_y4_patient563_1.json b/563/InvasionFront_CD3_block7_x4_y4_patient563_1.json new file mode 100644 index 0000000000000000000000000000000000000000..691afc0bb0bd8a4f1fc407c73496c9331f1dd5f9 --- /dev/null +++ b/563/InvasionFront_CD3_block7_x4_y4_patient563_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14117.5, + "Centroid Y µm": 9544.9, + "Num Detections": 22271, + "Num Negative": 16110, + "Num Positive": 6161, + "Positive %": 27.66, + "Num Positive per mm^2": 2448.0 + } +} \ No newline at end of file diff --git a/563/InvasionFront_CD8_block7_x3_y4_patient563_0.json b/563/InvasionFront_CD8_block7_x3_y4_patient563_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a133cbe88f4a3fc526fbc06d07a0476a729a81a8 --- /dev/null +++ b/563/InvasionFront_CD8_block7_x3_y4_patient563_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12993.1, + "Centroid Y µm": 10394.5, + "Num Detections": 19175, + "Num Negative": 17739, + "Num Positive": 1436, + "Positive %": 7.489, + "Num Positive per mm^2": 633.1 + } +} \ No newline at end of file diff --git a/563/InvasionFront_CD8_block7_x4_y4_patient563_1.json b/563/InvasionFront_CD8_block7_x4_y4_patient563_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dd4e03dc7c41c6cbdde74e9cc0c5d8cee032f8cc --- /dev/null +++ b/563/InvasionFront_CD8_block7_x4_y4_patient563_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 10569.4, + "Num Detections": 23189, + "Num Negative": 19936, + "Num Positive": 3253, + "Positive %": 14.03, + "Num Positive per mm^2": 1324.9 + } +} \ No newline at end of file diff --git a/563/TumorCenter_CD3_block7_x3_y4_patient563_0.json b/563/TumorCenter_CD3_block7_x3_y4_patient563_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7eb7b74045e379417e764bec10929bd5e7a57a38 --- /dev/null +++ b/563/TumorCenter_CD3_block7_x3_y4_patient563_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 10019.7, + "Num Detections": 22395, + "Num Negative": 13150, + "Num Positive": 9245, + "Positive %": 41.28, + "Num Positive per mm^2": 3599.7 + } +} \ No newline at end of file diff --git a/563/TumorCenter_CD3_block7_x4_y4_patient563_1.json b/563/TumorCenter_CD3_block7_x4_y4_patient563_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7c689a5cbd21d229bff0dec31174f4ab8e6f05b8 --- /dev/null +++ b/563/TumorCenter_CD3_block7_x4_y4_patient563_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 10069.7, + "Num Detections": 20373, + "Num Negative": 19100, + "Num Positive": 1273, + "Positive %": 6.248, + "Num Positive per mm^2": 509.54 + } +} \ No newline at end of file diff --git a/563/TumorCenter_CD8_block7_x3_y4_patient563_0.json b/563/TumorCenter_CD8_block7_x3_y4_patient563_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4df7edbe031f413c47ab86a37ff00cc08a2154cd --- /dev/null +++ b/563/TumorCenter_CD8_block7_x3_y4_patient563_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 10144.6, + "Num Detections": 25007, + "Num Negative": 22208, + "Num Positive": 2799, + "Positive %": 11.19, + "Num Positive per mm^2": 1103.4 + } +} \ No newline at end of file diff --git a/563/TumorCenter_CD8_block7_x4_y4_patient563_1.json b/563/TumorCenter_CD8_block7_x4_y4_patient563_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8fde4becf18beb334596764335475bfbbba4301a --- /dev/null +++ b/563/TumorCenter_CD8_block7_x4_y4_patient563_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 10144.6, + "Num Detections": 20898, + "Num Negative": 20340, + "Num Positive": 558, + "Positive %": 2.67, + "Num Positive per mm^2": 226.9 + } +} \ No newline at end of file diff --git a/563/history_text.txt b/563/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc1470d282987731bacb314e59fc63d56cf71702 --- /dev/null +++ b/563/history_text.txt @@ -0,0 +1 @@ +The patient has had a progressive left cervical mass for a long time. Prior to the operation, the patient underwent galvanotherapy, which is one of the alternative healing methods. This resulted in massive burning of the skin. \ No newline at end of file diff --git a/563/icd_codes.txt b/563/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2770660c26e82cc7a5e928e61e1ef4528738e535 --- /dev/null +++ b/563/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Fossa tonsillaris[C09.0 ] \ No newline at end of file diff --git a/563/ops_codes.txt b/563/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8ba91b4bcee7dda724d6f10adf3bb03be5cc12f7 --- /dev/null +++ b/563/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Pharyngoplastik mit lokaler Schleimhaut[5-293.0 ] \ No newline at end of file diff --git a/563/patient_clinical_data.json b/563/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0501095278b2bf6e6655d2fd8ebf081398b8eae7 --- /dev/null +++ b/563/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 47, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 36, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/563/patient_pathological_data.json b/563/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8a46c095000f2d4eefeb1e6a6c6b94a5c7613284 --- /dev/null +++ b/563/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "563", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 11, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/563/surgery_description.txt b/563/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d6f16d40e102ae58f530ae135001584bd7beabdf --- /dev/null +++ b/563/surgery_description.txt @@ -0,0 +1 @@ +Tonsillektomie, Neck dissection diff --git a/563/surgery_report.txt b/563/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..631e387829b7126ab7235690c7e1478af1154411 --- /dev/null +++ b/563/surgery_report.txt @@ -0,0 +1 @@ +Initial inspection of the tonsil region. The tonsils are very small on both sides and rather unremarkable from a macroscopic point of view. A tumor tonsillectomy was performed on the left side due to an abnormal PET-CT finding. Incision of the anterior palatal arch and dissection of the tonsil with removal of some musculature under bipolar coagulation, then sending the tonsil marked with a thread for frozen section. Unfortunately, the pathologist found carcinoma in situ in the area of the anterior palatal arch and medially. These areas will be resected. A large resection is performed on the anterior palatal arch in the mucosal area and also on the posterior palatal arch in the mucosal area and then marginal samples are taken in each case. However, the new marginal samples are then free of tumor and carcinoma in situ. In the meantime, a PEG was performed using the thread pull-through method with without any problems. Rearrangement for neck dissection, as already mentioned the skin looks very burnt. It almost has the aspect of postradiation skin. A skin incision is made at the anterior edge of the sternocleidomastoid. Palpation reveals a very thick, large mass that already occupies a large part of the sternocleidomastoid muscle. After the skin incision, dissection is extremely difficult as the tissue is sulfurously inflamed, which is due to galvanotherapy. You have to fight your way through thick scar plates and through tissue that bleeds very easily. The sternocleidomastoid muscle is exposed first in the lower and then in the very upper area. A platysmal flap is formed in the posterior and anterior region. The sternocleidomastoid muscle is first released laterally, then an attempt to release it with the laser is unsuccessful. The internal jugular vein is pulled completely into the metastasis, it is ligated above and below and then removed. The internal carotid artery and the vagus nerve can be spared, as can the coronary artery. Then remove the entire neck specimen after separating the sternocleidomastoid muscle in the upper and lower area so that the entire neck specimen can be removed en bloc with thick caked metastases. Intraoperative demonstration on and , demonstrating that the metastasis runs directly through the cervical plexus and could not be detached from it. The plexus branches are therefore also removed. Then hemostasis by means of bipolar coagulation and irrigation. During dissection, the lingual artery is torn and must be ligated. If a very radical approach is required, the neck dissection on the opposite side is initially omitted. The oral cavity and oropharynx are then inspected again. A relatively large defect can be seen laterally, where neck fat also emerges at one point. A mucosal flap is therefore formed with the posterior palatal arch to minimize bleeding and the risk of fistula. The patient is admitted to the intensive care unit. \ No newline at end of file diff --git a/564/InvasionFront_CD3_block1_x1_y6_patient564_0.json b/564/InvasionFront_CD3_block1_x1_y6_patient564_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f445c6eec2dbb7ac8dd449a2bc057e7620d8b202 --- /dev/null +++ b/564/InvasionFront_CD3_block1_x1_y6_patient564_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 16416.3, + "Num Detections": 17577, + "Num Negative": 17056, + "Num Positive": 521, + "Positive %": 2.964, + "Num Positive per mm^2": 262.82 + } +} \ No newline at end of file diff --git a/564/InvasionFront_CD3_block1_x2_y6_patient564_1.json b/564/InvasionFront_CD3_block1_x2_y6_patient564_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69fffcdb45a5105714962e6f98f482f0cab7e2b0 --- /dev/null +++ b/564/InvasionFront_CD3_block1_x2_y6_patient564_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6721.4, + "Centroid Y µm": 16566.2, + "Num Detections": 18267, + "Num Negative": 15628, + "Num Positive": 2639, + "Positive %": 14.45, + "Num Positive per mm^2": 1226.6 + } +} \ No newline at end of file diff --git a/564/InvasionFront_CD8_block1_x1_y6_patient564_0.json b/564/InvasionFront_CD8_block1_x1_y6_patient564_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dc68d5c87d505a46b554b0ef11fd1420b552891e --- /dev/null +++ b/564/InvasionFront_CD8_block1_x1_y6_patient564_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 15042.0, + "Num Detections": 15968, + "Num Negative": 15560, + "Num Positive": 408, + "Positive %": 2.555, + "Num Positive per mm^2": 238.74 + } +} \ No newline at end of file diff --git a/564/InvasionFront_CD8_block1_x2_y6_patient564_1.json b/564/InvasionFront_CD8_block1_x2_y6_patient564_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f2f708184d536c7c9dfef2627e1457a9d0279fc4 --- /dev/null +++ b/564/InvasionFront_CD8_block1_x2_y6_patient564_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6796.4, + "Centroid Y µm": 15042.0, + "Num Detections": 20760, + "Num Negative": 18109, + "Num Positive": 2651, + "Positive %": 12.77, + "Num Positive per mm^2": 1070.2 + } +} \ No newline at end of file diff --git a/564/TumorCenter_CD3_block1_x1_y8_patient564_0.json b/564/TumorCenter_CD3_block1_x1_y8_patient564_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2cf32efac4985c30563da29846badb02d297726a --- /dev/null +++ b/564/TumorCenter_CD3_block1_x1_y8_patient564_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 20264.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/564/TumorCenter_CD3_block1_x2_y8_patient564_1.json b/564/TumorCenter_CD3_block1_x2_y8_patient564_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2a5c5dbeb0fb20f0d58e19cc3228c29014b6e5ce --- /dev/null +++ b/564/TumorCenter_CD3_block1_x2_y8_patient564_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6242.6, + "Centroid Y µm": 20029.6, + "Num Detections": 9009, + "Num Negative": 8608, + "Num Positive": 401, + "Positive %": 4.451, + "Num Positive per mm^2": 321.61 + } +} \ No newline at end of file diff --git a/564/TumorCenter_CD8_block1_x1_y6_patient564_0.json b/564/TumorCenter_CD8_block1_x1_y6_patient564_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1a938f99d1ec611d293673bfc8477ef54df1c744 --- /dev/null +++ b/564/TumorCenter_CD8_block1_x1_y6_patient564_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 23762.4, + "Num Detections": 19574, + "Num Negative": 18570, + "Num Positive": 1004, + "Positive %": 5.129, + "Num Positive per mm^2": 419.45 + } +} \ No newline at end of file diff --git a/564/TumorCenter_CD8_block1_x2_y6_patient564_1.json b/564/TumorCenter_CD8_block1_x2_y6_patient564_1.json new file mode 100644 index 0000000000000000000000000000000000000000..888ab1d00c3a7dc5c561766b1c0b00f5f6b49633 --- /dev/null +++ b/564/TumorCenter_CD8_block1_x2_y6_patient564_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8895.3, + "Centroid Y µm": 23812.4, + "Num Detections": 18998, + "Num Negative": 15588, + "Num Positive": 3410, + "Positive %": 17.95, + "Num Positive per mm^2": 1398.3 + } +} \ No newline at end of file diff --git a/564/history_text.txt b/564/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0ca61fee59d4748aa3c24ff04e96c93f0c68a3e9 --- /dev/null +++ b/564/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed oropharyngeal carcinoma in the area of the palatal arch, tonsillar lobe and oropharyngeal side wall on the left. An additional suspicious focus in the right vallecula area could be excluded with regard to malignancy by biopsy during the pre-panendoscopy. Therefore, the above-mentioned surgery is now indicated. There is cN2b status on the right. \ No newline at end of file diff --git a/564/icd_codes.txt b/564/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/564/ops_codes.txt b/564/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/564/patient_clinical_data.json b/564/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cb46044ef9fa12896c06351ae2ab151c8d0524fb --- /dev/null +++ b/564/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 68, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/564/patient_pathological_data.json b/564/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3a53bea9502258535ac580ec50949ad6146cc3f3 --- /dev/null +++ b/564/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "564", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/564/surgery_description.txt b/564/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0d52f192ffbaee82620147e25918862427aab155 --- /dev/null +++ b/564/surgery_description.txt @@ -0,0 +1 @@ +Resektion, Neck diss. bds., PEG-Anlage, Tracheotomie, Defektdeckung, Freier Lappen (Radialis) diff --git a/564/surgery_report.txt b/564/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f0e0c5cfab0a1506fcdb13b75b15b027e19ee92f --- /dev/null +++ b/564/surgery_report.txt @@ -0,0 +1 @@ +Initial consultation with the anesthesiologist. First pharyngoscopy and laryngoscopy: The described tumor is seen in the area of the palatal arch extending to the left side, just to the tonsillar lobe, on the right side transition to the tonsillar lobe or oropharyngeal side wall and growth caudally to the border to the base of the tongue. Inspection of the right vallecula again. No tumor here. Performing the PEG insertion: insertion of the esophagoscope into the stomach. After creating the diaphanoscopy, insertion of a 15 mm abdominal wall tube without complications. Fixation to the abdominal wall in the typical manner. Sterile dressing. Therefore now transoral tumor resection. The tumor is resected on all sides with a safety margin of 1-1.5 cm. The entire palatal arch, including the upper tonsillar lobe, the tonsillar lobe and parts of the oropharyngeal side wall on the right, including the wall in the deeper muscular area, are resected up to the base of the tongue, which is only resected at the edges, or up to the entrance of the hypopharynx. The specimen is removed and thread-marked, both at the edges of the mucosa and basally. In addition, a marginal sample is taken from the left in the area of the palatal arch and adjacent to the tonsillar lobe as well as caudally on the right at the border to the hypopharynx. Both the margins of the specimen and the edge samples are tumor-free. Thus R0 situation. Repositioning of the patient. Abjoding. Injection of a total of 10 ml Ultracaine 1% with adrenaline into both sides of the neck. Sterile draping of all relevant surgical areas. Start with the neck dissection on the right: skin incision curved in the typical manner. Exposure of the sternocleidomastoid muscle. Exposure of the digastric and omohyoid muscles. Detachment of the fat lymph node package from the sternocleidomastoid muscle. Exposure of the internal jugular vein, facial vein and external jugular vein. Exposure of the internal carotid artery, external carotid artery. Exposure of the superior thyroid artery, facial artery and lingual artery. Exposure, displacement and at the end of the operation re-embedding, in the sense of neurolysis, of the following nerves: hypoglossal nerve, vagus nerve, accessorius nerve and the branches of the cervical plexus. Overall clearing level II to V. Several definite or at least probably malignant lymph nodes cranially in level II to III. Careful irrigation and hemostasis. Transition to neck dissection on the left: This is performed in the same way as on the right side. Level II to IV evacuation is performed, exposing the structures also described on the right, as well as exposure, relocation and, at the end of the operation, re-embedding of the following nerves: hypoglossal nerve, vagus nerve, accessorius nerve and the branches of the cervical plexus. Then tracheostoma creation: small Kocher collar incision. Exposure of the subcutaneous tissue up to the infrahyoid musculature. This is split. The thyroid isthmus is passed underneath, clamped, severed and ligated using puncture ligatures. The trachea is then exposed. Exposure of a small, wide-stalked, modified Björ flap and epithelialization of the same. Re-intubation. Subsequent elevation of the radial flap: marking of the required flap dimension after measurement. Length 10.5 cm, maximum width 6- 6.5 cm. Mark the flap in the left forearm area with the central radial artery. First cut around the flap ulnarly, subfascially. Then extend the incision into the crook of the elbow. Exposure of the pedicle under the brachioradialis muscle. Exposure of the superficial venous system with connection between the superficial and deep venous system. Subsequent radial incision of the flap and subfascial detachment. Exposure of the lateral antebrachial cutaneous nerve. The radial artery is exposed caudally and initially clamped. After constant saturation between 95 and 100% for at least 15 minutes, the artery is severed and sutured proximally and distally using 4.0 Prolene stitches. The flap is then removed. Outgoing small vessels are treated bipolar or with clips. Dissection up to the crook of the elbow. Two outlets in the area of the cephalic vein and a smaller outlet in the area of the confluence can be dissected. Before exposing the radial artery, the interosseous artery is cut and clipped after prior clamping. The flap is then removed. Ligation in the area of the proximal venous stumps. The stump of the radial artery is treated at the entrance to the brachial artery by means of stitches above and below 6.0 Vascufil. Careful hemostasis and irrigation in the forearm area. Primary closure of the skin up to the defect. Defect is closed with split skin. This is removed from the thigh area using a dermatome and successively incorporated into the forearm defect. Subsequent application of Mepilex dressing, loose swab dressing. Wrapping with absorbent cotton. Fitting of a Cramer splint and wrapping with an elastic bandage. Attachment of the arm. Thigh area is treated with hydrocolloid dressing. After application, the hand always shows no signs of saturation and no signs of reduced circulation. Removal of the flap: After removal, the flap was already rinsed with heparin. Creation of a tunnel through the residual pharyngeal wall. This is at least 2 transverse fingers wide. Careful hemostasis here. Pass the stalk outwards into the soft tissues of the neck. The flap is sutured in successively, partly from the outside, through sutures placed in front, partly transorally. The defect can be completely closed without tension. The flap is sutured dorsally and ventrally to the remains of the palatal arch and folded. Then vascular anastomosis. Conditioning of the superior thyroid artery. This can be dissected quite close to the exit from the externa in the appropriate size. The arteries are anastomosed using 9.0 Ethilon single-button sutures. After opening the clamp, good arterial flow, good venous return. A portion of the facial vein and the external jugular vein are conditioned for the venous anastomosis. A branch of the cephalic vein is anastomosed with the external jugular vein using a coupler, post-conditioning of the veins. A 2.5 mm coupler is used. After opening the clamps, there is good venous flow. Positive smear phenomenon. The other outlet of the cephalic vein is then anastomosed with the outlet from the facial vein, also using a 2.5 m coupler after prior conditioning of the vessels. Good venous return here too, positive smear phenomenon. The small outlet in the confluence area is closed with two clips. Careful irrigation and hemostasis. The wound is closed by inserting two flaps on the right side, whereby the stalk shows a visible protrusion in the area of the middle of the skin suture. Nevertheless, marking of the site for Doppler control using Vicryl suture. The left side had already been closed in layers with the insertion of a Redon drain. Here, too, careful hemostasis and irrigation were performed beforehand. Application of a pressure bandage on the right and left. The tracheal cannula is then fixed with sutures. Intraoral inspection of the flap again. This is well supplied with blood. Completion of the procedure without complications. Final consultation with the anesthetist. The patient goes to the intensive care unit for monitoring. Please continue the intraoperative antibiotic treatment with Unacid for one week. Please carry out clinical checks and Doppler checks on vitality and blood flow in the radial lobe for 5 days. Heparin 500 units/hour was started intraoperatively and should be continued for a total of 5 days. Please feed for 7-10 days via the inserted PEG tube. Food build-up according to clinical findings, if necessary after swallowing porridge. After receiving the final histology, please attend the interdisciplinary tumor conference. \ No newline at end of file diff --git a/565/InvasionFront_CD3_block14_x3_y10_patient565_0.json b/565/InvasionFront_CD3_block14_x3_y10_patient565_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f48097bb0e464521189c33ef2ad89eee26b2be66 --- /dev/null +++ b/565/InvasionFront_CD3_block14_x3_y10_patient565_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11443.9, + "Centroid Y µm": 28834.7, + "Num Detections": 2763, + "Num Negative": 2610, + "Num Positive": 153, + "Positive %": 5.537, + "Num Positive per mm^2": 391.41 + } +} \ No newline at end of file diff --git a/565/InvasionFront_CD3_block14_x4_y10_patient565_1.json b/565/InvasionFront_CD3_block14_x4_y10_patient565_1.json new file mode 100644 index 0000000000000000000000000000000000000000..93e9eb95e1ad0ebebab5223cddf8101a7a9e7f4c --- /dev/null +++ b/565/InvasionFront_CD3_block14_x4_y10_patient565_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14005.1, + "Centroid Y µm": 28972.2, + "Num Detections": 19635, + "Num Negative": 16937, + "Num Positive": 2698, + "Positive %": 13.74, + "Num Positive per mm^2": 1252.2 + } +} \ No newline at end of file diff --git a/565/InvasionFront_CD8_block14_x3_y10_patient565_0.json b/565/InvasionFront_CD8_block14_x3_y10_patient565_0.json new file mode 100644 index 0000000000000000000000000000000000000000..27668101e8475b4c483c447ada19e20d43990012 --- /dev/null +++ b/565/InvasionFront_CD8_block14_x3_y10_patient565_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11668.8, + "Centroid Y µm": 24412.1, + "Num Detections": 16029, + "Num Negative": 14147, + "Num Positive": 1882, + "Positive %": 11.74, + "Num Positive per mm^2": 967.9 + } +} \ No newline at end of file diff --git a/565/InvasionFront_CD8_block14_x4_y10_patient565_1.json b/565/InvasionFront_CD8_block14_x4_y10_patient565_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eb8fe1126306de36ac076f6d2f62872187798f77 --- /dev/null +++ b/565/InvasionFront_CD8_block14_x4_y10_patient565_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14217.5, + "Centroid Y µm": 24587.0, + "Num Detections": 18174, + "Num Negative": 16929, + "Num Positive": 1245, + "Positive %": 6.85, + "Num Positive per mm^2": 583.17 + } +} \ No newline at end of file diff --git a/565/TumorCenter_CD3_block14_x3_y10_patient565_0.json b/565/TumorCenter_CD3_block14_x3_y10_patient565_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ed42db7cd9baab8af78e3a8297d02ab6e23db119 --- /dev/null +++ b/565/TumorCenter_CD3_block14_x3_y10_patient565_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 25336.6, + "Num Detections": 16125, + "Num Negative": 14970, + "Num Positive": 1155, + "Positive %": 7.163, + "Num Positive per mm^2": 524.0 + } +} \ No newline at end of file diff --git a/565/TumorCenter_CD3_block14_x4_y10_patient565_1.json b/565/TumorCenter_CD3_block14_x4_y10_patient565_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f861afce22fb2220896ea9a5e05a9d2884dae7e4 --- /dev/null +++ b/565/TumorCenter_CD3_block14_x4_y10_patient565_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 25436.5, + "Num Detections": 11326, + "Num Negative": 10217, + "Num Positive": 1109, + "Positive %": 9.792, + "Num Positive per mm^2": 515.27 + } +} \ No newline at end of file diff --git a/565/TumorCenter_CD8_block14_x3_y10_patient565_0.json b/565/TumorCenter_CD8_block14_x3_y10_patient565_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2462ecd19ebbbde6c5e279f472d927ef1c74c3ed --- /dev/null +++ b/565/TumorCenter_CD8_block14_x3_y10_patient565_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10594.4, + "Centroid Y µm": 25436.5, + "Num Detections": 15869, + "Num Negative": 15449, + "Num Positive": 420, + "Positive %": 2.647, + "Num Positive per mm^2": 192.98 + } +} \ No newline at end of file diff --git a/565/TumorCenter_CD8_block14_x4_y10_patient565_1.json b/565/TumorCenter_CD8_block14_x4_y10_patient565_1.json new file mode 100644 index 0000000000000000000000000000000000000000..44f67fc8ef50074276e04efbff3a3f4cc026e6e7 --- /dev/null +++ b/565/TumorCenter_CD8_block14_x4_y10_patient565_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13068.1, + "Centroid Y µm": 25486.5, + "Num Detections": 14649, + "Num Negative": 14100, + "Num Positive": 549, + "Positive %": 3.748, + "Num Positive per mm^2": 256.0 + } +} \ No newline at end of file diff --git a/565/history_text.txt b/565/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b0f1619fb28885f7d1eaf90662b2020b2879248d --- /dev/null +++ b/565/history_text.txt @@ -0,0 +1 @@ +The patient presented with an exophytic mass on the edge of the tongue on the left side; clinical examination was virtually impossible as the patient repeatedly refused palpation. A preoperative palpation examination prior to surgery was therefore not possible. \ No newline at end of file diff --git a/565/icd_codes.txt b/565/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/565/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/565/ops_codes.txt b/565/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c84b082c4297ad0dad85229355f820e7ce5a6e0 --- /dev/null +++ b/565/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Exzision erkranktes Gewebe Glandula submandibularis[5-261.4 L] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/565/patient_clinical_data.json b/565/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..75add3a6ce75e4a2155ad1454d5e09c9496b70ae --- /dev/null +++ b/565/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/565/patient_pathological_data.json b/565/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..550ba39d8bb212753745c1c2b2ea0bba9c0b7eaa --- /dev/null +++ b/565/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "565", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 23, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 19.0 +} \ No newline at end of file diff --git a/565/surgery_description.txt b/565/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d8ab9fe0be3ee33eb5b82027b40ed1707c767b49 --- /dev/null +++ b/565/surgery_description.txt @@ -0,0 +1 @@ +Zungenteilresektion, Tracheotomie diff --git a/565/surgery_report.txt b/565/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..551ec89e11b15e2f188701d19fd0fea36f7597ea --- /dev/null +++ b/565/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues, then insertion of the spandex and a covered retractor and inspection and palpation of the tumor region. On inspection, the tumor appears relatively superficial, but on palpation the tumor extends to the midline into the tongue muscles and also into the deep tongue muscles. Intraoperative consultation of and demonstration of the findings. It became clear that defect coverage using a free transpalantate would be necessary after the tumor resection, so it was decided to perform only the tumor resection on this day and to perform defect coverage using a free radialis graft and neck dissection in a two-stage procedure. Unfortunately, preoperative planning in this regard was not possible due to the patient's lack of compliance. The diode laser was initially set to 20 watts and the tumor region was first cut around the upper edge of the tongue. In the course of the operation, the wattage must be increased to 30. The tumor is partially resected using a monopolar needle. Ultimately, the tumor is completely removed with a safety margin of 1 cm. The entire specimen is placed on cork for frozen section, all margins including the deep margins are free of carcinoma. There is still carcinoma in situ at the margin of the floor of the mouth, so a resection is taken here and a margin sample is taken again for frozen section. All margins are definitively R0. Higher grade dysplasia at the dorsal margin in the floor of the mouth, therefore a resection is taken here and a margin sample is taken, which is finally sent for histology without a frozen section. Overall, all margins R0 in the frozen section. Hemostasis with bipolar coagulation and completion of the procedure without complications. Please plan graft coverage without delay using a radialis graft and neck dissection. A day point must be reserved for this. In this case, it is also possible to perform the operation on a Tuesday, Wednesday or Friday if the pre-reserved flap appointments are already taken. The surgeon repositions the patient for the tracheotomy in the head reclination position. Injection of Suprarenin below the cricoid cartilage (8 ml). Sterile abjodation and draping of the patient. Skin incision 1/2 cm below the cricoid cartilage (horizontal). Bipolar coagulation of the superficial veins. Spreading dissection of the infrahyal musculature and vertical incision. The infrahyal musculature is pushed laterally on both sides and the cricoid cartilage is exposed. Exposure of the thyroid isthmus and undermining of the thyroid isthmus with a clamp. Bipolar coagulation of the isthmus and gradual sharp transection. Push the thyroid flaps away from the trachea and bipolar coagulation until the wound is completely dry. Identification of the incision site between the 2nd and 3rd tracheal ring. Sharp incision of the trachea after saturation of the patient. Visor tracheotomy. Suturing of the tracheostoma first at the lower, then at the upper part in the sense of an epithelialized tracheostoma. Removal of the tube and insertion of an 8 mm tracheostomy tube. Completion of the tracheostomy without complications. \ No newline at end of file diff --git a/566/InvasionFront_CD3_block18_x5_y6_patient566_0.json b/566/InvasionFront_CD3_block18_x5_y6_patient566_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c6f3da667e1b5bc3430275754118e8fe4a1e71f2 --- /dev/null +++ b/566/InvasionFront_CD3_block18_x5_y6_patient566_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 20114.3, + "Num Detections": 18989, + "Num Negative": 16713, + "Num Positive": 2276, + "Positive %": 11.99, + "Num Positive per mm^2": 1013.3 + } +} \ No newline at end of file diff --git a/566/InvasionFront_CD3_block18_x6_y6_patient566_1.json b/566/InvasionFront_CD3_block18_x6_y6_patient566_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e407903681a4d41e05223b718cfbb66faa1c6092 --- /dev/null +++ b/566/InvasionFront_CD3_block18_x6_y6_patient566_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 20264.3, + "Num Detections": 21238, + "Num Negative": 17644, + "Num Positive": 3594, + "Positive %": 16.92, + "Num Positive per mm^2": 1493.0 + } +} \ No newline at end of file diff --git a/566/InvasionFront_CD8_block18_x5_y6_patient566_0.json b/566/InvasionFront_CD8_block18_x5_y6_patient566_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b09c57c3937838d8410496c62a4143376687f945 --- /dev/null +++ b/566/InvasionFront_CD8_block18_x5_y6_patient566_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 22837.9, + "Num Detections": 18215, + "Num Negative": 16697, + "Num Positive": 1518, + "Positive %": 8.334, + "Num Positive per mm^2": 654.38 + } +} \ No newline at end of file diff --git a/566/InvasionFront_CD8_block18_x6_y6_patient566_1.json b/566/InvasionFront_CD8_block18_x6_y6_patient566_1.json new file mode 100644 index 0000000000000000000000000000000000000000..28bc20e978f54059b8a351d62ea2426baaf53c90 --- /dev/null +++ b/566/InvasionFront_CD8_block18_x6_y6_patient566_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 22887.9, + "Num Detections": 22874, + "Num Negative": 20058, + "Num Positive": 2816, + "Positive %": 12.31, + "Num Positive per mm^2": 1132.8 + } +} \ No newline at end of file diff --git a/566/TumorCenter_CD3_block18_x5_y6_patient566_0.json b/566/TumorCenter_CD3_block18_x5_y6_patient566_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7d4ebef409ade5ba36afab27e5f0c5b122e1616b --- /dev/null +++ b/566/TumorCenter_CD3_block18_x5_y6_patient566_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15754.2, + "Centroid Y µm": 14654.7, + "Num Detections": 15602, + "Num Negative": 13718, + "Num Positive": 1884, + "Positive %": 12.08, + "Num Positive per mm^2": 868.28 + } +} \ No newline at end of file diff --git a/566/TumorCenter_CD3_block18_x6_y6_patient566_1.json b/566/TumorCenter_CD3_block18_x6_y6_patient566_1.json new file mode 100644 index 0000000000000000000000000000000000000000..57aad725d2d3596b641af8da0811a96881479053 --- /dev/null +++ b/566/TumorCenter_CD3_block18_x6_y6_patient566_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18165.4, + "Centroid Y µm": 14729.7, + "Num Detections": 18442, + "Num Negative": 18261, + "Num Positive": 181, + "Positive %": 0.9815, + "Num Positive per mm^2": 86.57 + } +} \ No newline at end of file diff --git a/566/TumorCenter_CD8_block18_x5_y6_patient566_0.json b/566/TumorCenter_CD8_block18_x5_y6_patient566_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c7dfc40d8e1a19bbaecdf94c1024e81b9c30b963 --- /dev/null +++ b/566/TumorCenter_CD8_block18_x5_y6_patient566_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 15566.8, + "Num Detections": 15673, + "Num Negative": 13170, + "Num Positive": 2503, + "Positive %": 15.97, + "Num Positive per mm^2": 1104.4 + } +} \ No newline at end of file diff --git a/566/TumorCenter_CD8_block18_x6_y6_patient566_1.json b/566/TumorCenter_CD8_block18_x6_y6_patient566_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cf1db4498f4036866748e2543acbbe983efa2c39 --- /dev/null +++ b/566/TumorCenter_CD8_block18_x6_y6_patient566_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18190.4, + "Centroid Y µm": 15591.7, + "Num Detections": 12922, + "Num Negative": 12803, + "Num Positive": 119, + "Positive %": 0.9209, + "Num Positive per mm^2": 69.48 + } +} \ No newline at end of file diff --git a/566/history_text.txt b/566/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf937bbff0466dbbccbccb8a857bb11097cfb1ec --- /dev/null +++ b/566/history_text.txt @@ -0,0 +1 @@ +In Mr. , a panendoscopy <2017> revealed a suspected cT2 cN0 glottic laryngeal carcinoma of the left side. Pathohistologically only verrucous leukoplakia, whereby a highly differentiated squamous cell carcinoma could not be excluded. Based on the clinical findings, however, a cT2 glottic laryngeal carcinoma of the left side must be assumed. Due to the lack of adjustability during the initial operation, there is now an indication for a partial laryngectomy from the outside. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/566/icd_codes.txt b/566/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..839d71d3d77786944828e3f3ea4cc3e1cc8a1edc --- /dev/null +++ b/566/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 B] \ No newline at end of file diff --git a/566/ops_codes.txt b/566/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5b508f4d896241bc9f7875f26c433bfac8e53f15 --- /dev/null +++ b/566/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] \ No newline at end of file diff --git a/566/patient_clinical_data.json b/566/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f0f021ad3a06bc0c5ba570a2245a01929556fff --- /dev/null +++ b/566/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/566/patient_pathological_data.json b/566/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..440b3eb825e286484a43d6a0faf5e3681e83e0fd --- /dev/null +++ b/566/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "566", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": 0.0 +} \ No newline at end of file diff --git a/566/surgery_description.txt b/566/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..770bdfa5ccdae6dfe3ced2fb277daabbd4aa237a --- /dev/null +++ b/566/surgery_description.txt @@ -0,0 +1 @@ +KK-Teilresektion diff --git a/566/surgery_report.txt b/566/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..38a3f918cfdd1facc60d00cdf234d341c792c0a0 --- /dev/null +++ b/566/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesia colleagues. Orotracheal intubation by the anesthesia colleagues using GlideScope optics. Fixation of the tube. Positioning of the patient in head reclination. Skin spray disinfection and infiltration anesthesia. Skin wipe disinfection and sterile draping. First mark the landmarks and the planned incision using the typical broken-line technique. Sharp cutting of the cutis as well as the subcutis. Dissection of the prelaryngeal musculature. Locating the linea alba. Blunt lateralization of the prelaryngeal musculature on both sides. Exposure of the laryngeal skeleton. Finding and exposing the cricothyroid ligament. Horizontal incision of the same. Subsequent paramedian incision of the perichondrium of the thyroid cartilage. Dissection of a typical perichondrium flap. Using the wheel, the larynx is now opened in the median line in the sense of a thyrofissure. Opening of the endolarynx in the median line. Insertion of the small retractor. An extensive, verrucous, tumorous process can now be seen, which encompasses the entire left vocal fold. The tumorous formation extends caudally into the subglottic appendix. Cranially, the tumor grows into the Morgagnian ventricle. The anterior commissure appears clinically tumor-free. Dorsally, the tumor growth extends at least as far as the vocal process. Circular resection of the tumor is now performed while maintaining the corresponding resection margins. In the ventral, cranial and caudal areas, the tumour can be mobilized relatively easily. Here, the resection is carried out with the vocalis muscle. In the dorsal parts, resection is somewhat more difficult. After appropriate oxygenation of the patient, the tube is retracted to ensure a better overview. The tumor is now removed in toto, taking the vocal process with it. Circular margin samples are taken and sent for frozen section diagnostics. In the area of the superior/posterior margin, i.e. in the area of the arys, there are still extensions of a carcinoma in situ. Therefore, the first step is to take the corresponding resected specimens and new margin samples in the two localizations mentioned above (superior/posterior and left arytenoid). As part of the intraoperative frozen section diagnostics, the second margin samples are evaluated as tumor-free. Only moderate dysplasia is detected here, with no evidence of carcinoma in situ. Meticulous hemostasis using bipolar coagulation. Creation of a total of four drill holes in the area of the thyroid cartilage. Removal of the retractor. Adaptation of the thyroid cartilage in the median line using PDS 4.0. Stitching over the incision in the area of the ligamentum conicum. Suturing of the previously prepared perichondrium flap. Readaptation of the prelaryngeal musculature in the median line. A sterile flap was inserted beforehand. Subcutaneous suture with 4.0 Vicryl and skin suture with Ethilon 5.0. Application of a wound dressing and completion of the operation without complications. Final consultation with anesthesia colleagues. \ No newline at end of file diff --git a/567/InvasionFront_CD3_block4_x1_y1_patient567_0.json b/567/InvasionFront_CD3_block4_x1_y1_patient567_0.json new file mode 100644 index 0000000000000000000000000000000000000000..21d91e75cac88e062eb9786f557eb85fa99f1c87 --- /dev/null +++ b/567/InvasionFront_CD3_block4_x1_y1_patient567_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 9270.1, + "Num Detections": 17279, + "Num Negative": 16885, + "Num Positive": 394, + "Positive %": 2.28, + "Num Positive per mm^2": 191.28 + } +} \ No newline at end of file diff --git a/567/InvasionFront_CD3_block4_x2_y1_patient567_1.json b/567/InvasionFront_CD3_block4_x2_y1_patient567_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cb23daef2bce48f634df655827faaa03940b471d --- /dev/null +++ b/567/InvasionFront_CD3_block4_x2_y1_patient567_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9445.0, + "Centroid Y µm": 9270.1, + "Num Detections": 20475, + "Num Negative": 19229, + "Num Positive": 1246, + "Positive %": 6.085, + "Num Positive per mm^2": 561.89 + } +} \ No newline at end of file diff --git a/567/InvasionFront_CD8_block4_x1_y1_patient567_0.json b/567/InvasionFront_CD8_block4_x1_y1_patient567_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac3051751c28d2f21a14c3f72598080b0a5f7034 --- /dev/null +++ b/567/InvasionFront_CD8_block4_x1_y1_patient567_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4447.6, + "Centroid Y µm": 7521.0, + "Num Detections": 18528, + "Num Negative": 18068, + "Num Positive": 460, + "Positive %": 2.483, + "Num Positive per mm^2": 211.94 + } +} \ No newline at end of file diff --git a/567/InvasionFront_CD8_block4_x2_y1_patient567_1.json b/567/InvasionFront_CD8_block4_x2_y1_patient567_1.json new file mode 100644 index 0000000000000000000000000000000000000000..71e3f650aa3b0f7332e796128276b29ccd856e61 --- /dev/null +++ b/567/InvasionFront_CD8_block4_x2_y1_patient567_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6796.4, + "Centroid Y µm": 7496.0, + "Num Detections": 21463, + "Num Negative": 20505, + "Num Positive": 958, + "Positive %": 4.463, + "Num Positive per mm^2": 422.76 + } +} \ No newline at end of file diff --git a/567/TumorCenter_CD3_block4_x1_y1_patient567_0.json b/567/TumorCenter_CD3_block4_x1_y1_patient567_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e04d7d2ac09793cfa07542786c08a18a50635896 --- /dev/null +++ b/567/TumorCenter_CD3_block4_x1_y1_patient567_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3823.0, + "Centroid Y µm": 2498.7, + "Num Detections": 17287, + "Num Negative": 16123, + "Num Positive": 1164, + "Positive %": 6.733, + "Num Positive per mm^2": 553.3 + } +} \ No newline at end of file diff --git a/567/TumorCenter_CD3_block4_x2_y1_patient567_1.json b/567/TumorCenter_CD3_block4_x2_y1_patient567_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3df5ffed2fcabc697045b43636d7157de94689f3 --- /dev/null +++ b/567/TumorCenter_CD3_block4_x2_y1_patient567_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 2598.6, + "Num Detections": 12934, + "Num Negative": 12573, + "Num Positive": 361, + "Positive %": 2.791, + "Num Positive per mm^2": 239.31 + } +} \ No newline at end of file diff --git a/567/TumorCenter_CD8_block4_x1_y1_patient567_0.json b/567/TumorCenter_CD8_block4_x1_y1_patient567_0.json new file mode 100644 index 0000000000000000000000000000000000000000..67c62d407ad70045873da037a387dbf32bf44e98 --- /dev/null +++ b/567/TumorCenter_CD8_block4_x1_y1_patient567_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5147.3, + "Centroid Y µm": 2248.8, + "Num Detections": 18944, + "Num Negative": 18092, + "Num Positive": 852, + "Positive %": 4.497, + "Num Positive per mm^2": 407.98 + } +} \ No newline at end of file diff --git a/567/TumorCenter_CD8_block4_x2_y1_patient567_1.json b/567/TumorCenter_CD8_block4_x2_y1_patient567_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dffef3cd5692b1bc7593168640587b72e5af0c6f --- /dev/null +++ b/567/TumorCenter_CD8_block4_x2_y1_patient567_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7621.0, + "Centroid Y µm": 2198.8, + "Num Detections": 13737, + "Num Negative": 13706, + "Num Positive": 31, + "Positive %": 0.2257, + "Num Positive per mm^2": 20.92 + } +} \ No newline at end of file diff --git a/567/history_text.txt b/567/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..74e60c86051c8cdb2937c345bdf4620cb78f291e --- /dev/null +++ b/567/history_text.txt @@ -0,0 +1 @@ +Patient referred by a specialist with histologically confirmed, moderately differentiated squamous cell carcinoma of the soft palate. Mirror endoscopy revealed an exophytic, partially ulcerating mass in the area of the base of the uvula on the anterior palatal arch extending to the left side. Sonographically V.a. cN1 neck status. There is now an indication for panendoscopy and tumor resection for squamous cell carcinoma that has already been histologically confirmed externally and for PEG placement. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/567/icd_codes.txt b/567/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..123b03be77611ae872b848d95c471d6f1ae9cfdd --- /dev/null +++ b/567/icd_codes.txt @@ -0,0 +1 @@ +Unsichere Neubildung der Uvula[D37.0 ] \ No newline at end of file diff --git a/567/ops_codes.txt b/567/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b36c0b9577370debfcbdcd1327aa6dd04b54312b --- /dev/null +++ b/567/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Gaumenbogenkarzinom-Resektion[5-272.1 ] Diagnostische Ösophagogastroskopie[1-631 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] \ No newline at end of file diff --git a/567/patient_clinical_data.json b/567/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..97e5589a386c10c3ce8484e9b88ca34c793b13f0 --- /dev/null +++ b/567/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/567/patient_pathological_data.json b/567/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..80e4386411b3de62157c93c5d6690931e5f3a10e --- /dev/null +++ b/567/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "567", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/567/surgery_description.txt b/567/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a3a0d34b88e6798ed933c72db99306433cd4646d --- /dev/null +++ b/567/surgery_description.txt @@ -0,0 +1 @@ +transorale Resektion, Freier Lappen (Radialis), PEG-Anlage, Panendoskopie diff --git a/567/surgery_report.txt b/567/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..48635c5d47f8dabdf33e8d93912f23e110e770d2 --- /dev/null +++ b/567/surgery_report.txt @@ -0,0 +1 @@ +After team time out and active patient identification, anesthesia is induced by the anesthesia colleagues. Transition to tracheoscopy: insertion with the rigid endoscope and smooth passage of the non-irritated glottis. Entry after endotracheal. Mucosal conditions are normal on all sides up to the tracheal bifurcation. Intubation is then performed by the surgeon. Positioning of the patient by the surgeon and insertion of the mouth guard. Entry with the size C small bore tube. Adjustment of the endolarynx. The mucosal conditions in the glottis and supraglottis area are inconspicuous on all sides. Adjustment of the anterior and posterior commissure. Here, too, there is no evidence of a tumor. Subsequent inspection of the piriform sinus on both sides. This is lined on both sides by smooth mucosa on all sides and can be freely unfolded up to the tip of the piriform sinus. Mucosal conditions in the area of the esophageal entrance and postcricoid are also unremarkable. Subsequent inspection of the vallecula and the base of the tongue. Here, too, there is no evidence of a tumor. Then insertion of the McIvor oral spatula and inspection of the oral cavity and epipharynx. Here the previously described tumorous mass in the area of the uvula base can be seen. This extends to the left paramedian side onto the anterior palatal arch. The suspicious mucosa also extends slightly to the paramedian right on the right side. Raise the uvula and inspect the posterior surface of the uvula. Suspicious, uneven mucosal conditions can also be seen here. These extend from the tip of the uvula beyond the base of the uvula to the posterior surface of the soft palate. Then mark the resection margins with the electric needle. A safety distance of at least 5 mm is maintained in all planes. Resection of the tumor under vision. In the area of the posterior surface of the soft palate, it can now be seen that the suspicious mucosal change extends relatively far cranially. The suspicious area is therefore resected under visualization. The tumor resectate is sent en bloc for frozen section diagnostics. A marginal sample is also taken in the area of the cranial soft palate posterior surface. This is also sent for frozen section diagnostics. As part of the frozen section diagnosis by telephone, questionable marginal carcinoma in situ in the area of the cranial resection surface of the back of the soft palate. Therefore, a representative resection specimen and 2 margin specimens were taken, some of which were sent in for definitive histology. Clinically macroscopically, a clear R0 resection is now present. Finally, esophagogastroscopy and PEG insertion are performed. Insertion of the endoscope under visualization and constant air insufflation into the stomach. This reveals a typical, inconspicuous gastric mucosal relief on all sides. Entering in inversion. Inspection of the gastroesophageal junction. This also appears normal and without irritation. The PEG is then inserted in the typical manner using the thread pull-through method and positive diaphanoscopy. At the end of the operation, final inspection of the enoral resection area. Repeated meticulous hemostasis using bipolar coagulation. Intraoperative demonstration of findings on . Completion of the operation without complications. Conclusion: Clinical macroscopic R0 resection of a cT1 cN1 uvular carcinoma. Should velopharyngeal insufficiency occur postoperatively, defect coverage using a radial flap would have to be discussed with the neck dissection still pending. \ No newline at end of file diff --git a/568/InvasionFront_CD3_block9_x5_y1_patient568_0.json b/568/InvasionFront_CD3_block9_x5_y1_patient568_0.json new file mode 100644 index 0000000000000000000000000000000000000000..710e0e05d8a8dd74f8323db556ca3d183cdd8579 --- /dev/null +++ b/568/InvasionFront_CD3_block9_x5_y1_patient568_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 3223.3, + "Num Detections": 18607, + "Num Negative": 15936, + "Num Positive": 2671, + "Positive %": 14.35, + "Num Positive per mm^2": 1398.3 + } +} \ No newline at end of file diff --git a/568/InvasionFront_CD3_block9_x6_y1_patient568_1.json b/568/InvasionFront_CD3_block9_x6_y1_patient568_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd0419cc95d818d248784d43741222ddaaa9bd3f --- /dev/null +++ b/568/InvasionFront_CD3_block9_x6_y1_patient568_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21444.7, + "Centroid Y µm": 3165.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/568/InvasionFront_CD8_block9_x5_y1_patient568_0.json b/568/InvasionFront_CD8_block9_x5_y1_patient568_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1d436d37087dcd4649fb18ec1f9f86542b902d7f --- /dev/null +++ b/568/InvasionFront_CD8_block9_x5_y1_patient568_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 6996.3, + "Num Detections": 11443, + "Num Negative": 8366, + "Num Positive": 3077, + "Positive %": 26.89, + "Num Positive per mm^2": 2603.1 + } +} \ No newline at end of file diff --git a/568/InvasionFront_CD8_block9_x6_y1_patient568_1.json b/568/InvasionFront_CD8_block9_x6_y1_patient568_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f1718135745a8e211d2ebca9fc5370575456a08c --- /dev/null +++ b/568/InvasionFront_CD8_block9_x6_y1_patient568_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21063.8, + "Centroid Y µm": 7496.0, + "Num Detections": 6847, + "Num Negative": 5848, + "Num Positive": 999, + "Positive %": 14.59, + "Num Positive per mm^2": 1319.4 + } +} \ No newline at end of file diff --git a/568/TumorCenter_CD3_block9_x5_y1_patient568_0.json b/568/TumorCenter_CD3_block9_x5_y1_patient568_0.json new file mode 100644 index 0000000000000000000000000000000000000000..83095e79bc6ba28c61f9f5cbc9bc730a9a461d19 --- /dev/null +++ b/568/TumorCenter_CD3_block9_x5_y1_patient568_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 8345.6, + "Num Detections": 19943, + "Num Negative": 10257, + "Num Positive": 9686, + "Positive %": 48.57, + "Num Positive per mm^2": 4066.7 + } +} \ No newline at end of file diff --git a/568/TumorCenter_CD3_block9_x6_y1_patient568_1.json b/568/TumorCenter_CD3_block9_x6_y1_patient568_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b71bedacc1269a46f7ed8fec92a0d8f93def883a --- /dev/null +++ b/568/TumorCenter_CD3_block9_x6_y1_patient568_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19589.6, + "Centroid Y µm": 8545.5, + "Num Detections": 21623, + "Num Negative": 13983, + "Num Positive": 7640, + "Positive %": 35.33, + "Num Positive per mm^2": 3125.2 + } +} \ No newline at end of file diff --git a/568/TumorCenter_CD8_block9_x5_y1_patient568_0.json b/568/TumorCenter_CD8_block9_x5_y1_patient568_0.json new file mode 100644 index 0000000000000000000000000000000000000000..273ad84569cd782dfc90973e467d6da96e34886e --- /dev/null +++ b/568/TumorCenter_CD8_block9_x5_y1_patient568_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 2848.5, + "Num Detections": 21426, + "Num Negative": 10652, + "Num Positive": 10774, + "Positive %": 50.28, + "Num Positive per mm^2": 4214.9 + } +} \ No newline at end of file diff --git a/568/TumorCenter_CD8_block9_x6_y1_patient568_1.json b/568/TumorCenter_CD8_block9_x6_y1_patient568_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4cb97ff348d6826b3c4384d8789f3cb1a4f4c008 --- /dev/null +++ b/568/TumorCenter_CD8_block9_x6_y1_patient568_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 2598.6, + "Num Detections": 21270, + "Num Negative": 12975, + "Num Positive": 8295, + "Positive %": 39.0, + "Num Positive per mm^2": 3444.3 + } +} \ No newline at end of file diff --git a/568/history_text.txt b/568/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d4b902d09f807cef7524fd01fba035634a520ee8 --- /dev/null +++ b/568/history_text.txt @@ -0,0 +1 @@ +The patient has a thickened, partially exulcerated right tonsil. In addition, a pronounced mass on the right side of the neck with infiltration of the sternocleidomastoid muscle. Therefore indication for the above mentioned operation. \ No newline at end of file diff --git a/568/icd_codes.txt b/568/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce196d0caa0ae248d8ca1cf26ea4b94de6b51cd3 --- /dev/null +++ b/568/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Fossa tonsillaris[C09.0 ] \ No newline at end of file diff --git a/568/ops_codes.txt b/568/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a61b6d9a995a178640a35fe902b01ad13a9676fb --- /dev/null +++ b/568/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Tonsillektomie (ohne Adenotomie): Radikal, transoral[5-281.2 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/568/patient_clinical_data.json b/568/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..907ced60485fbbc802c24cc701102368e5b0e834 --- /dev/null +++ b/568/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/568/patient_pathological_data.json b/568/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..27bed8a0bdd59a3b046c2341f1c19ac9a7eb104a --- /dev/null +++ b/568/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "568", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Lymphoepithelial", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/568/surgery_description.txt b/568/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a36479844e56d26cc98d53e13a4ec036af5b2f01 --- /dev/null +++ b/568/surgery_description.txt @@ -0,0 +1 @@ +Tonsillektomie , Panendo diff --git a/568/surgery_report.txt b/568/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5e8bebec95e2482271c2fe46c3ae225861f61793 --- /dev/null +++ b/568/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthetist, tracheoscopy is performed using the 0-degree scope. This reveals inconspicuous mucosal conditions subglottically up to the carina. Now orotracheal intubation through the anesthesia ( for Cormack I). Now proceed to pharyngoscopy and laryngoscopy: Here the right tonsil is clearly bulging with an ulcer of approx. 5 mm at the punctum maximum. Subsequently, better exploration reveals a highly fissured, slightly exophytic central area. The rest of the pharynx, hypopharynx and larynx are unremarkable. Now proceed to flexible esophagogastroscopy. The mucosa is unremarkable on all sides. Now insertion of the tonsil plug. First video and photo documentation of the findings. Then consult . He does not recommend performing a biopsy, but rather a complete resection of the tonsil. This is also carried out very carefully, in the sense of a radical tonsillectomy. Macroscopically, an R0 resection is achieved in any case, but the distance to the tumor appears to be small basally and caudally, which is why a final margin sample is also taken in this area. Subsequent careful hemostasis using bipolar coagulation and hydrogen. Relaxation and re-tensioning of the oral retractors and, if the blood is dry, completion of the procedure without bleeding and without complications. Conclusion: suspected cT1 to cT2 tonsillar carcinoma of the right side, which was resected. In the case of R0 resection, a neck dissection of the right side and, if necessary, insertion of a PEG should be performed. \ No newline at end of file diff --git a/569/InvasionFront_CD3_block21_x5_y8_patient569_0.json b/569/InvasionFront_CD3_block21_x5_y8_patient569_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d055654ed122d1921bfbd8fef6f962c158bffe0a --- /dev/null +++ b/569/InvasionFront_CD3_block21_x5_y8_patient569_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 30933.6, + "Num Detections": 16583, + "Num Negative": 15804, + "Num Positive": 779, + "Positive %": 4.698, + "Num Positive per mm^2": 362.18 + } +} \ No newline at end of file diff --git a/569/InvasionFront_CD3_block21_x6_y8_patient569_1.json b/569/InvasionFront_CD3_block21_x6_y8_patient569_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d8614880baf60dde813b86c43067b9d809178d8c --- /dev/null +++ b/569/InvasionFront_CD3_block21_x6_y8_patient569_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21088.8, + "Centroid Y µm": 31158.5, + "Num Detections": 5491, + "Num Negative": 5389, + "Num Positive": 102, + "Positive %": 1.858, + "Num Positive per mm^2": 134.34 + } +} \ No newline at end of file diff --git a/569/InvasionFront_CD8_block21_x5_y8_patient569_0.json b/569/InvasionFront_CD8_block21_x5_y8_patient569_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f89decb4de29002bf831929cdb54117e649cc991 --- /dev/null +++ b/569/InvasionFront_CD8_block21_x5_y8_patient569_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 19664.6, + "Num Detections": 17837, + "Num Negative": 17709, + "Num Positive": 128, + "Positive %": 0.7176, + "Num Positive per mm^2": 56.7 + } +} \ No newline at end of file diff --git a/569/InvasionFront_CD8_block21_x6_y8_patient569_1.json b/569/InvasionFront_CD8_block21_x6_y8_patient569_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9f701a3e8d4b206abda781729213e8be9ae04455 --- /dev/null +++ b/569/InvasionFront_CD8_block21_x6_y8_patient569_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 19589.6, + "Num Detections": 22396, + "Num Negative": 22309, + "Num Positive": 87, + "Positive %": 0.3885, + "Num Positive per mm^2": 37.05 + } +} \ No newline at end of file diff --git a/569/TumorCenter_CD3_block21_x5_y8_patient569_0.json b/569/TumorCenter_CD3_block21_x5_y8_patient569_0.json new file mode 100644 index 0000000000000000000000000000000000000000..69e127f7d5603d8ac1675abea4f96d37d968cd57 --- /dev/null +++ b/569/TumorCenter_CD3_block21_x5_y8_patient569_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16054.0, + "Centroid Y µm": 22563.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/569/TumorCenter_CD3_block21_x6_y8_patient569_1.json b/569/TumorCenter_CD3_block21_x6_y8_patient569_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b651e00aa319061617f4d73979b2e851f4ccf71 --- /dev/null +++ b/569/TumorCenter_CD3_block21_x6_y8_patient569_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18602.7, + "Centroid Y µm": 22600.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/569/TumorCenter_CD8_block21_x5_y8_patient569_0.json b/569/TumorCenter_CD8_block21_x5_y8_patient569_0.json new file mode 100644 index 0000000000000000000000000000000000000000..79a533c00ff40815952afee375f34e61815343ee --- /dev/null +++ b/569/TumorCenter_CD8_block21_x5_y8_patient569_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18240.3, + "Centroid Y µm": 35056.4, + "Num Detections": 17192, + "Num Negative": 17085, + "Num Positive": 107, + "Positive %": 0.6224, + "Num Positive per mm^2": 50.5 + } +} \ No newline at end of file diff --git a/569/TumorCenter_CD8_block21_x6_y8_patient569_1.json b/569/TumorCenter_CD8_block21_x6_y8_patient569_1.json new file mode 100644 index 0000000000000000000000000000000000000000..09eaf0276552956792047263fe55e4d8c99a23a6 --- /dev/null +++ b/569/TumorCenter_CD8_block21_x6_y8_patient569_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20664.1, + "Centroid Y µm": 35181.4, + "Num Detections": 10781, + "Num Negative": 10728, + "Num Positive": 53, + "Positive %": 0.4916, + "Num Positive per mm^2": 36.77 + } +} \ No newline at end of file diff --git a/569/history_text.txt b/569/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..828cf58f8c477246980d98ac0f46dbe0ba7f8f09 --- /dev/null +++ b/569/history_text.txt @@ -0,0 +1 @@ +The patient has a cT1a glottic carcinoma. Indication for laser resection. \ No newline at end of file diff --git a/569/icd_codes.txt b/569/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/569/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/569/ops_codes.txt b/569/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cdd992070d971d6e852adcb5dc6137597222552c --- /dev/null +++ b/569/ops_codes.txt @@ -0,0 +1 @@ +Lasertechnik: CO2-Laser[5-985.1 ] Mikrochirurgische Technik[5-984 ] Reoperation[5-983 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Exzision, mikrolaryngoskopisch[5-300.2 ] \ No newline at end of file diff --git a/569/patient_clinical_data.json b/569/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f755a4fc1c67a6fe68804f143fcf104f951e2268 --- /dev/null +++ b/569/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 80, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/569/patient_pathological_data.json b/569/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a2ef5bd99a526f0ff39a023d5b1634330dbcb3e3 --- /dev/null +++ b/569/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "569", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/569/surgery_description.txt b/569/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f71ffb574d9cb199582c43a70d74f2b3e887fe5c --- /dev/null +++ b/569/surgery_description.txt @@ -0,0 +1 @@ +Laserresektion diff --git a/569/surgery_report.txt b/569/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..148cd1e12b230b9f25cb9620d10960ff51f5787a --- /dev/null +++ b/569/surgery_report.txt @@ -0,0 +1 @@ +After orotracheal intubation through the anesthesia by means of a laser tube, adjustment of the findings with the size C small bore tube, this works well. Inclusion of the microscope. At a wattage of 6 in the continues mode, the findings are now ablated from cranial to caudal or anterior to posterior under microlaryngoscopic view in the healthy state. The anterior and posterior quadrants are then sampled for frozen section diagnosis. A further marginal sample is taken macroscopically from the anterior commissure far anteriorly in healthy tissue. The sent marginal samples are classified as R0 in the frozen section, too little material is obtained in the area of the anterior commissure for a reliable diagnosis. After consultation with the pathology department and examination of the microscopic findings in the commissure area, an R0 situation can be assumed. After placing supranasal swabs, the procedure is terminated at this point. \ No newline at end of file diff --git a/570/InvasionFront_CD3_block2_x1_y2_patient570_0.json b/570/InvasionFront_CD3_block2_x1_y2_patient570_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0fd79556f11adbaee7bcde50caa2dbba6e3020f7 --- /dev/null +++ b/570/InvasionFront_CD3_block2_x1_y2_patient570_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 18615.1, + "Num Detections": 20375, + "Num Negative": 18797, + "Num Positive": 1578, + "Positive %": 7.745, + "Num Positive per mm^2": 689.18 + } +} \ No newline at end of file diff --git a/570/InvasionFront_CD3_block2_x2_y2_patient570_1.json b/570/InvasionFront_CD3_block2_x2_y2_patient570_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b420ac3ccc72d3d85ae88b7ddb2a6a61f5ad9f52 --- /dev/null +++ b/570/InvasionFront_CD3_block2_x2_y2_patient570_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9020.2, + "Centroid Y µm": 18590.2, + "Num Detections": 22795, + "Num Negative": 21680, + "Num Positive": 1115, + "Positive %": 4.891, + "Num Positive per mm^2": 440.98 + } +} \ No newline at end of file diff --git a/570/InvasionFront_CD8_block2_x1_y2_patient570_0.json b/570/InvasionFront_CD8_block2_x1_y2_patient570_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f9022a13d71f33bd2f03dc13c2f671a8c70ddd6b --- /dev/null +++ b/570/InvasionFront_CD8_block2_x1_y2_patient570_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5497.1, + "Centroid Y µm": 6271.7, + "Num Detections": 21533, + "Num Negative": 19279, + "Num Positive": 2254, + "Positive %": 10.47, + "Num Positive per mm^2": 996.57 + } +} \ No newline at end of file diff --git a/570/InvasionFront_CD8_block2_x2_y2_patient570_1.json b/570/InvasionFront_CD8_block2_x2_y2_patient570_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3bb153f44e2b5c3a346cddaa635f7d35dbe59855 --- /dev/null +++ b/570/InvasionFront_CD8_block2_x2_y2_patient570_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7795.9, + "Centroid Y µm": 6246.7, + "Num Detections": 23452, + "Num Negative": 22296, + "Num Positive": 1156, + "Positive %": 4.929, + "Num Positive per mm^2": 466.68 + } +} \ No newline at end of file diff --git a/570/TumorCenter_CD3_block2_x1_y2_patient570_0.json b/570/TumorCenter_CD3_block2_x1_y2_patient570_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ae093d83402d3873adcd5ef1a53df60628ffd918 --- /dev/null +++ b/570/TumorCenter_CD3_block2_x1_y2_patient570_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4697.5, + "Centroid Y µm": 4772.5, + "Num Detections": 21483, + "Num Negative": 19985, + "Num Positive": 1498, + "Positive %": 6.973, + "Num Positive per mm^2": 655.54 + } +} \ No newline at end of file diff --git a/570/TumorCenter_CD3_block2_x2_y2_patient570_1.json b/570/TumorCenter_CD3_block2_x2_y2_patient570_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aada77afa4cf6c7a7e11b4f2ffcd80045224b03b --- /dev/null +++ b/570/TumorCenter_CD3_block2_x2_y2_patient570_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7196.2, + "Centroid Y µm": 4822.4, + "Num Detections": 20265, + "Num Negative": 18511, + "Num Positive": 1754, + "Positive %": 8.655, + "Num Positive per mm^2": 768.84 + } +} \ No newline at end of file diff --git a/570/TumorCenter_CD8_block2_x1_y2_patient570_0.json b/570/TumorCenter_CD8_block2_x1_y2_patient570_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6e37e6029ba1d8e1082bca755ac43057ec37a156 --- /dev/null +++ b/570/TumorCenter_CD8_block2_x1_y2_patient570_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 5122.3, + "Num Detections": 23288, + "Num Negative": 22783, + "Num Positive": 505, + "Positive %": 2.168, + "Num Positive per mm^2": 221.29 + } +} \ No newline at end of file diff --git a/570/TumorCenter_CD8_block2_x2_y2_patient570_1.json b/570/TumorCenter_CD8_block2_x2_y2_patient570_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b5b2830bbfaac162f381ee630202e6186a9d2229 --- /dev/null +++ b/570/TumorCenter_CD8_block2_x2_y2_patient570_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8295.6, + "Centroid Y µm": 5022.3, + "Num Detections": 21774, + "Num Negative": 21211, + "Num Positive": 563, + "Positive %": 2.586, + "Num Positive per mm^2": 244.19 + } +} \ No newline at end of file diff --git a/570/history_text.txt b/570/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..60cdfdcfb2ee024f4b397ecbed0f702cfff351c8 --- /dev/null +++ b/570/history_text.txt @@ -0,0 +1 @@ +Patient with oropharyngeal carcinoma on the left. Progression, size progression recognizable. In the last CT per continuitatem growth from the area of the tonsil loge, oropharyngeal wall in the direction of an N3 metastasis, which also infiltrates the sternocleidomastoid muscle and the neighboring structures. Due to the tumor volume, the above-mentioned intervention is indicated. \ No newline at end of file diff --git a/570/icd_codes.txt b/570/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed4aa87497852c75f601688357848e31931e81a2 --- /dev/null +++ b/570/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/570/ops_codes.txt b/570/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8dda12737d515faf2e36896a1d4d01ba26c1d380 --- /dev/null +++ b/570/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Temporäre Tracheotomie[5-311.0 ] Perkutane [endoskopische] Gastrostomie [PEG][5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 4 Regionen[5-403.10 R] Transplantat[5-295.04 ] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhautdeckung großflächig Empfängerstelle Unterarm[5-902.68 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/570/patient_clinical_data.json b/570/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..615a0851827259c8aa7cd39a815648198497d238 --- /dev/null +++ b/570/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 39, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/570/patient_pathological_data.json b/570/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..48412f6098e740fb9bdf48fb0f3b03deff1788ab --- /dev/null +++ b/570/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "570", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4b", + "pN_stage": "pN2c", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 10.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R2", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/570/surgery_description.txt b/570/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9bf6d9609a87f95dfbb851976cb2a794926871e2 --- /dev/null +++ b/570/surgery_description.txt @@ -0,0 +1 @@ +transcervicale Tumorresektion mit erweiterter radikaler Neck dissection, Lappendeckung (Radialis) diff --git a/570/surgery_report.txt b/570/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cce4da224db49a7e7472f555f4bc78e9b7a5cccd --- /dev/null +++ b/570/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy and laryngoscopy: The tumor is found with ulceration in the area of the tonsil lobe, transition to the base of the tongue. Tumor is not very mobile and shows deep infiltration. As already recognizable in the pre-ultrasound or CT. Now sterile draping, injection of a total of 15 ml Ultracaine 1% with adrenaline into both sides of the neck. Start with transoral resection: Cut around the inside of the tumor with a safety margin of at least 1.5 cm to 2 cm on all sides. The tumor can be well dissected in the dorsal area up to the .................. musculature. Marginal samples are taken from the palatal arch, from the palatal arch extending laterally to the alveolar ridge, from the alveolar ridge extending to the middle of the tongue body, from the base of the tongue and from the posterior palatal arch area and the upper two thirds of the posterior wall of the hypopharynx. Tissue is also removed from the basal area directly above the tonsil lobe up to the per................. Musculature, which is sent in as cranial basal medial. All marginal samples are tumor-free in the frozen section. PEG insertion: advancement of the flexible esophagoscope into the stomach, where ............. diaphanoscopy is performed in a typical manner. Insertion of a 15 mm abdominal wall tube. Fixation to the abdominal wall. Sterile dressing. Now continue the tumor resection from the outside: skin incision as for neck dissection. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. A large tumor conglomerate can be seen cranially. This infiltrates the sternocleidomastoid muscle, the internal jugular vein, the accessorius nerve and also grows into the external carotid artery. Cranial and caudal insertion of the sternocleidomastoid muscle. The internal jugular vein is also removed cranially and caudally and ligated twice. The cranial operation shows that the tumor can be easily dissected from the caudal edge of the parotid gland. Subsequently, touched tissue with suspected tumor infiltration is seen in the area of the digastric muscle. All muscles of the ............... fan are also resected, as is the submandibular gland. The hypoglossal nerve is clearly infiltrated by the tumor and is also resected. Further medial dissection shows that the tumor of the internal carotid artery can be dissected. The vagus nerve appears to be infiltrated. A marginal sample is taken, which shows clear tumor infiltrates. Resection of the vagus nerve and also the border cord, which is also involved in the tumor conglomerate. Separation of the carotid artery above the superior thyroid artery and suturing of this. Further branches of the lingual artery and facial artery and other smaller branches of the external carotid artery are included in the tumor preparation. Cranially, the external carotid artery is also ligated twice below the entrance to the parotid gland, as caudally. It can be seen that the tumor is growing from the pharyngeal wall towards the N3 metastases, as already visible in the imaging. Here the tumor is incised and dissected so that the neck preparation can be pushed off to the side. When the neck dissection is continued, level V a is massively interspersed with hardened lymph nodes, which indicate tumor infiltration. This means that almost all branches of the cervical plexus are resected as well as parts of the deep neck muscles. Resection extends caudally up to the venous angle. Level V b is also resected. The final result is an extended radical neck dissection. The part that grows per continuitatem in the direction of the tumor is marked with a suture. The tumor resection is then continued. All soft tissue structures are removed except for the internal carotid artery, including the parts of the masticatory muscles medial to the mandible. Resection extends basally to the prevertebral musculature. Middle area Adherence of the tumor to the musculature. This is partially resected as well. The resection also reveals massive retropharyngeal lymph nodes, which are thickened and appear to be infiltrated by the tumor. All lymph nodes are resected. The resection extends cranially to the entry of the carotid artery into the base of the skull. A cuff of 1 cm around the carotid artery remains suspicious for tumor. From all soft tissue in the area of the cranial ............... muscles and also from the suspicious cuff around the carotid artery. This is also sent to the frozen section as a cranial basal lateral sample. A marginal sample is also taken from the middle area, from the area of the prevertebral musculature, which is sent as medial basal. Continue the resection in the caudal direction. Here it extends to the piriform sinus entrance and includes parts of the arytenoid fold. A caudal basal margin sample is taken from the deep soft tissue. Mucosal margin samples are also taken from the piriform sinus and from the lower part of the hypopharynx up to the arytenoid region. All mucosal margin samples are healthy. The caudal basal margin sample is also healthy. Tumor infiltrate is visible in the medial basal margin specimen. Extensive resection of the prevertebral soft tissues is performed and another margin sample is taken. The cranial basal lateral margin specimen is not healthy, but broadly infiltrated by tumor. Extensive resection around the carotid artery is also performed here. However, the tissue quality does not change, so that tumor infiltration can be assumed here. Another marginal sample is taken. The marginal sample from the central area is negative, but there are still extensive tumor infiltrates from the marginal sample in the cuff around the internal carotid artery, which had now been visualized until shortly before entering the base of the skull. Laterally, .......... Due to the massive infiltration, which is also visible macroscopically, there is now an R2 situation at the base of the skull. Continuation is not possible without endangering the patient's life due to the massive infiltration. Therefore, wide coagulation of the tissue. Neck dissection is now performed on the right side: visualization of the sternocleidomastoid muscle. Exposure of the omohyoid and digastric muscles. Exposure of the cervical vascular sheath, common carotid artery, internal and external carotid artery, internal jugular vein and facial vein. Exposure of the superior thyroid artery and also the lingual and facial arteries. Careful attention is paid to the preservation of the arteries. Also visualization of the external jugular artery. Several .............. lymph nodes are now also removed during level II to V evacuation. The submandibular gland is also removed on this side in order to gain the facial artery for insertion of the flap. The accessory nerve and hypoglossal nerve can be exposed and preserved. Subsequently, tracheotomy in the typical manner and epithelialization of the cartilage to the neck skin after entering the 2nd/3rd intercartilaginous space. A small tracheostoma is created. Subsequently, the radialis flap is removed to cover the defect: the size of the defect is carefully measured in three dimensions and recorded on the forearm. Also recording a skin......... Successive lifting of the flap with skin........... First .............subfascial, then from radial. The radialis is ligated and treated using 4.0 Prolene sutures. All outgoing vessels are treated with ligatures or clips. The superficial and deep venous system is removed and exposed in the antecubital region, where it is exposed cranial to the cephalic vein and also a ............. of the radial vein. The radial artery is removed shortly before the exit of the interosseous artery. The stump is supplied with 4.0 Prolene. The veins are removed and the flap preparation is flushed with heparin. The veins are treated with ligatures. The procedure was performed under tourniquet. After opening the tourniquet, the flap reperfused well. Careful hemostasis in the area of the forearm skin. The cranial area is closed in layers. Defect is covered with split skin from the thigh. This was removed with a dermatome. Split skin with a thickness of 0.7 mm was obtained. This is successively incorporated into the defect, resulting in complete defect coverage. The thigh wound is treated with a hydrogel-Mepilex dressing. The forearm wound is treated with a Mepilex and hydrogel Lavanid dressing. Then wrap in absorbent cotton and apply a forearm splint using an elastic bandage. Repositioning of the arm splint. Due to the vascular situation on the left side, a tunnel is now created to the right side of the neck across the prelaryngeal muscles. This is three transverse fingers wide. The radialis flap is successively sutured into the defect using 3.0 Vicryl single-button sutures, whereby the overview is sometimes difficult. Tension-free suturing and complete coverage of the three-dimensional defect is achieved. The flap stalk is passed through the tunnel to the right side. Veins and arteries are conditioned here. The flap is sutured to the facial artery using 8.0 Ethilon single-button sutures. Good venous return after opening the clamps. The ..................................... veins are sutured between the cephalic vein and a branch of the facial vein using the 3.5 coupler system. After opening the clamps, good venous return............. ...... positive. The confluence of the radial artery is closed with clips. The stump of the outlet of the facial vein is also closed using clips and ligature. Subsequent irrigation of the entire wound area as well as shortly after completion of the tumor resection and careful hemostasis. Wound closure in layers on both sides of the neck with the insertion of a Redon drain. The skin monitor is sutured into place via a separate skin incision on the right paramedian side due to the course of the stalk in the anterior neck area. An 8-gauge cannula with a core is inserted and sutured in place. Once again the flap from transoral, good blood circulation. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue antibiotics with Unacid for one week, as well as administration of heparin via perfusor 500 units per hour for 5 days. Flap control according to the scheme for 5 days. Feeding via the inserted PEG for 10 - 12 days. Then X-ray pre-swallow and, if necessary, diet build-up. Considerable dysphagia is to be expected with the extension of the resection, therefore early initiation of swallowing rehabilitation, including presentation to the voice and speech department. \ No newline at end of file diff --git a/571/InvasionFront_CD8_block20_x5_y12_patient571_0.json b/571/InvasionFront_CD8_block20_x5_y12_patient571_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b82cf9fb0044da2b5d7394ba170c49ce8e39ae76 --- /dev/null +++ b/571/InvasionFront_CD8_block20_x5_y12_patient571_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17540.7, + "Centroid Y µm": 29959.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/571/InvasionFront_CD8_block20_x6_y12_patient571_1.json b/571/InvasionFront_CD8_block20_x6_y12_patient571_1.json new file mode 100644 index 0000000000000000000000000000000000000000..41d8caa075e4f4920a078a20126c4b5d7bdae3f6 --- /dev/null +++ b/571/InvasionFront_CD8_block20_x6_y12_patient571_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19989.4, + "Centroid Y µm": 29884.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/571/TumorCenter_CD3_block20_x5_y12_patient571_0.json b/571/TumorCenter_CD3_block20_x5_y12_patient571_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8733d2aa281a0341c08811de8511cd5f6407b7cd --- /dev/null +++ b/571/TumorCenter_CD3_block20_x5_y12_patient571_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16226.2, + "Centroid Y µm": 28674.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/571/TumorCenter_CD3_block20_x6_y12_patient571_1.json b/571/TumorCenter_CD3_block20_x6_y12_patient571_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e95c416d94ae5d16c66b40b087c0bdaa1fb5b167 --- /dev/null +++ b/571/TumorCenter_CD3_block20_x6_y12_patient571_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18838.3, + "Centroid Y µm": 28794.5, + "Num Detections": 1, + "Num Negative": 1, + "Num Positive": 0, + "Positive %": 0.0, + "Num Positive per mm^2": 0.0 + } +} \ No newline at end of file diff --git a/571/TumorCenter_CD8_block20_x5_y12_patient571_0.json b/571/TumorCenter_CD8_block20_x5_y12_patient571_0.json new file mode 100644 index 0000000000000000000000000000000000000000..85d5b84221addd56b848bc8b676931b92fd1a127 --- /dev/null +++ b/571/TumorCenter_CD8_block20_x5_y12_patient571_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 29784.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/571/TumorCenter_CD8_block20_x6_y12_patient571_1.json b/571/TumorCenter_CD8_block20_x6_y12_patient571_1.json new file mode 100644 index 0000000000000000000000000000000000000000..346658730edf3d0e75c73c670a7dca040b5e8b7a --- /dev/null +++ b/571/TumorCenter_CD8_block20_x6_y12_patient571_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18563.1, + "Centroid Y µm": 30248.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/571/history_text.txt b/571/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/571/icd_codes.txt b/571/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5644383875ba24e9749fa467a1f0690b8c881132 --- /dev/null +++ b/571/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] Supraglottisches Karzinom[C32.1 ] Karzinom Oropharynx Hinterwand[C10.3 ] \ No newline at end of file diff --git a/571/ops_codes.txt b/571/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..345efa31cf508d45234e0c9dd2ea68db0dfe822f --- /dev/null +++ b/571/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Permanente Tracheotomie[5-312.0 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] \ No newline at end of file diff --git a/571/patient_clinical_data.json b/571/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d3c79d36f18f3385b705285533d073b70be80b0e --- /dev/null +++ b/571/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/571/patient_pathological_data.json b/571/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0479a41d2ffbd5c7b390cd2393e9704279ba442f --- /dev/null +++ b/571/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "571", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 14.0 +} \ No newline at end of file diff --git a/571/surgery_description.txt b/571/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9b49ae1a285f3d205d07e0098c57981b53695be9 --- /dev/null +++ b/571/surgery_description.txt @@ -0,0 +1 @@ +Laryngektomie, Neck dissection, permanente Tracheotomie diff --git a/571/surgery_report.txt b/571/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b27ab23593745163834db363f570d12843bd58b0 --- /dev/null +++ b/571/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and nasal intubation by the anesthetist. First, pharyngoscopy again. An exophytic mass was found on the posterior pharyngeal wall on the left side. Then, anterior reflection and inspection of the piriform sinuses on both sides. These are unremarkable. Then adjustment of the glottic plane. The left pocket fold and the left vocal fold are completely covered by the tumor. The tumor moves ventrally to the opposite side. The laryngeal epiglottis is also infiltrated by the tumor. Sterile covering. Creation of an apron flap by subplatysmal dissection in the typical manner. Veins are bipolized or ligated. The apron flap is dissected up to the level of the hyoid bone or the submandibular gland. The apron flap is then folded upwards and fixed in place with retaining sutures. Neck dissection on the right side. Exposure and free preparation of the sternocleidomastoid muscle. Then exposure of the omohyoid muscle and the digastric muscle. Exposure of the submandibular gland and exploration of the cervical vascular sheath. Exposure of the accessorius nerve. Then free preparation of the internal jugular vein. Exposure of the internal/external carotid artery and vagus nerve and exposure of the accessorius nerve and hypoglossal nerve. Release of level II to V while preserving the branches of the cervical plexus. Exposure of the facial vein and release of the medial neck block. The superior thyroid artery was cut and ligated. Then switch to the left side and modified radical neck dissection, in principle in the same way. Exposure of the sternocleidomastoid muscle, omohyoid muscle and digastric muscle. Exposure of the cervical vascular sheath and the accessorius nerve. Exposure of the internal jugular vein, external/internal carotid artery, vagus nerve, accessorius nerve and hypoglossal nerve. All structures can be preserved. Clearing of levels II to V while preserving the branches of the cervical plexus. Exposure of the thyroid gland and free preparation of the trachea on the anterior wall. Opening of the trachea between the 1st and 2nd tracheal cartilage. Creation of a mucocutaneous anastomosis on the anterior wall of the trachea. Re-intubation and transition to laryngectomy. Separation of the infrahyoid muscles at the hyoid bone. Exposure of the upper horn of the thyroid cartilage and dissection of the prelaryngeal muscles. Release and dissection of the pharyngeal tube. Blunt dissection of the piriform sinus. Performing a small tansversal pharyngotomy and entering the larynx while pulling out the epiglottis. Detachment of the pharyngeal tube from the laryngeal preparation up to the level of the cricoid cartilage. Separation of the larynx from the trachea and preservation of the cricoid cartilage. Sending the laryngeal preparation with suture marking for frozen section. The pathologist assesses all margins as tumor-free. Then inspection of the pharyngeal tube and placement of a left-lateral myotomy on the esophagus. Insertion of a Provox prosthesis size 80 in the typical manner. was called in intraoperatively to demonstrate this. The placement of this voice prosthesis was successful. Then transition to the pharyngeal suture. First the first layer between the mucosal remnants. Then placement of a further single button suture on top. Finally, the constrictor pharyngeal muscle is sutured over it as a third single button suture. The prelaryngeal residual musculature and the infrahyoid musculature as the fourth suture are also placed over it in the form of single button sutures. Once again careful hemostasis with bipolar coagulation. Insertion of two Redon drains. Two-layer wound closure. Insertion of a 10 mm tracheostomy tube. Completion of the procedure without complications. Patient transferred to the intensive care unit for monitoring. Continue antibiotics for 24 hours. Please keep the patient fasting for 10 days, followed by an X-ray gruel swallow and, if necessary, a diet. In the meantime, nutrition via PEG tube. Postoperative presentation in the phoniatrics department to initiate voice rehabilitation and presentation of the patient at the tumor conference. \ No newline at end of file diff --git a/572/InvasionFront_CD3_block8_x1_y12_patient572_0.json b/572/InvasionFront_CD3_block8_x1_y12_patient572_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7687be9b67982bf62c05459c7b81932184f6513b --- /dev/null +++ b/572/InvasionFront_CD3_block8_x1_y12_patient572_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4022.9, + "Centroid Y µm": 40553.5, + "Num Detections": 17423, + "Num Negative": 15331, + "Num Positive": 2092, + "Positive %": 12.01, + "Num Positive per mm^2": 941.79 + } +} \ No newline at end of file diff --git a/572/InvasionFront_CD3_block8_x2_y12_patient572_1.json b/572/InvasionFront_CD3_block8_x2_y12_patient572_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9cfeb6e079d6afea3199c616e0d344c54050d7b6 --- /dev/null +++ b/572/InvasionFront_CD3_block8_x2_y12_patient572_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6748.9, + "Centroid Y µm": 40449.7, + "Num Detections": 7780, + "Num Negative": 6333, + "Num Positive": 1447, + "Positive %": 18.6, + "Num Positive per mm^2": 1675.6 + } +} \ No newline at end of file diff --git a/572/InvasionFront_CD8_block8_x1_y12_patient572_0.json b/572/InvasionFront_CD8_block8_x1_y12_patient572_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c306ef8d76f852d07ce5f08b9c14c2209f5d86e4 --- /dev/null +++ b/572/InvasionFront_CD8_block8_x1_y12_patient572_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3098.4, + "Centroid Y µm": 30009.1, + "Num Detections": 19988, + "Num Negative": 17103, + "Num Positive": 2885, + "Positive %": 14.43, + "Num Positive per mm^2": 1257.5 + } +} \ No newline at end of file diff --git a/572/InvasionFront_CD8_block8_x2_y12_patient572_1.json b/572/InvasionFront_CD8_block8_x2_y12_patient572_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e41fdc8c6e188a777198bab79f7ac05f8f61fea0 --- /dev/null +++ b/572/InvasionFront_CD8_block8_x2_y12_patient572_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5647.0, + "Centroid Y µm": 30209.0, + "Num Detections": 8039, + "Num Negative": 5545, + "Num Positive": 2494, + "Positive %": 31.02, + "Num Positive per mm^2": 2651.6 + } +} \ No newline at end of file diff --git a/572/TumorCenter_CD3_block8_x1_y12_patient572_0.json b/572/TumorCenter_CD3_block8_x1_y12_patient572_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8e3393e89c34074fec2f09cc0254553426d596df --- /dev/null +++ b/572/TumorCenter_CD3_block8_x1_y12_patient572_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6075.7, + "Centroid Y µm": 31628.5, + "Num Detections": 20429, + "Num Negative": 14192, + "Num Positive": 6237, + "Positive %": 30.53, + "Num Positive per mm^2": 2819.0 + } +} \ No newline at end of file diff --git a/572/TumorCenter_CD3_block8_x2_y12_patient572_1.json b/572/TumorCenter_CD3_block8_x2_y12_patient572_1.json new file mode 100644 index 0000000000000000000000000000000000000000..63197af08a15b9d8be37497b196572caa55a7b67 --- /dev/null +++ b/572/TumorCenter_CD3_block8_x2_y12_patient572_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8695.4, + "Centroid Y µm": 31558.3, + "Num Detections": 22240, + "Num Negative": 16421, + "Num Positive": 5819, + "Positive %": 26.16, + "Num Positive per mm^2": 2569.6 + } +} \ No newline at end of file diff --git a/572/TumorCenter_CD8_block8_x1_y12_patient572_0.json b/572/TumorCenter_CD8_block8_x1_y12_patient572_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7261fc8c919e024b3e758c41ed2bca259f4febaa --- /dev/null +++ b/572/TumorCenter_CD8_block8_x1_y12_patient572_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5272.2, + "Centroid Y µm": 30533.8, + "Num Detections": 27340, + "Num Negative": 22119, + "Num Positive": 5221, + "Positive %": 19.1, + "Num Positive per mm^2": 1980.7 + } +} \ No newline at end of file diff --git a/572/TumorCenter_CD8_block8_x2_y12_patient572_1.json b/572/TumorCenter_CD8_block8_x2_y12_patient572_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b5acf2a6e503244d507077cbc865634f350f320e --- /dev/null +++ b/572/TumorCenter_CD8_block8_x2_y12_patient572_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7895.8, + "Centroid Y µm": 30383.9, + "Num Detections": 24582, + "Num Negative": 18787, + "Num Positive": 5795, + "Positive %": 23.57, + "Num Positive per mm^2": 2270.1 + } +} \ No newline at end of file diff --git a/572/history_text.txt b/572/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4dbccb5a729ed70d61a6c7ce3139ffccb7a9b293 --- /dev/null +++ b/572/history_text.txt @@ -0,0 +1 @@ +Cervical mass level II on the right, sonographic cN3 neck status. Largest progressive mass since 1 year. Noxenanamnesis and mirror findings of exophytic mass of the right tonsil clinically cT2 now indication for the above mentioned operation. \ No newline at end of file diff --git a/572/icd_codes.txt b/572/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2fd46ff2130bd9443e6d941c920bf108b4a75061 --- /dev/null +++ b/572/icd_codes.txt @@ -0,0 +1 @@ +Tonsillentumor[D37.0 ] \ No newline at end of file diff --git a/572/ops_codes.txt b/572/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6740df467d77306cf9dbaabc05108df14325319e --- /dev/null +++ b/572/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/572/patient_clinical_data.json b/572/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a5983ee9320167879b099e132706bd5e0bdf738b --- /dev/null +++ b/572/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 67, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/572/patient_pathological_data.json b/572/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5fd6c48698de1e5939b8775b99e0efab99ca2df0 --- /dev/null +++ b/572/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "572", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 8.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/572/surgery_description.txt b/572/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..96a0afd8f10a819cbaf1e9571adb486b83e2d7a8 --- /dev/null +++ b/572/surgery_description.txt @@ -0,0 +1 @@ +Tonsillektomie, PEG-Anlage sowie Panendo diff --git a/572/surgery_report.txt b/572/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b7943e156a084903238281cef2c47b86b14b4d9e --- /dev/null +++ b/572/surgery_report.txt @@ -0,0 +1 @@ +Before intubation tracheoscopy: Mucosa up to the carina free on all sides and without irritation. Intubation by the anesthesia colleagues. Insertion of the Kleinsasser C-tube after dental protection: Oral cavity: Tongue and floor of the mouth as well as oral vestibule, inspectorically and palpatorily no space occupation/resistance. Orophaynx: Centrally retracted exulcerating mass of the right tonsil. The uvula is free, the anterior palatal arch is contact vulnerable with macroscopically inconspicuous mucosa, the posterior palatal arch is free and the tumor does not extend beyond the caudal tonsil pole. Total size approx. 2 x 3.5 cm. Hard and soft palate free, left tonsillar lobe inconspicuous tonsil, also glossoalveolar furrows free on both sides. Posterior wall of oropharynx free. Base of tongue unremarkable on inspection and palpation. Vallecula epiglottica free. Hypopharynx: Postcricoid and piriform sinus free on both sides. Larynx: Epiglottis, aryepiglottic fold, arytenoid region on both sides, folds of pockets on both sides as well as vocal folds on both sides and anterior and posterior commissure on all sides no masses. Mucous membranes smooth. Tumor tonsillectomy on the right: insertion of the Mc Ivor oral flap with fixed teeth. Very good overview. Marking of the resection margins using an electric needle. Entry at the anterior palatal arch with the electric needle and dissection caudally in the muscle layer, whereby the wound bed is macroscopically tumor-free. Successive tonsillectomy with repeated hemostasis using bipolar. In the case of minor vascular bleeding and with protection of the posterior palatal arch, whereby an approx. 0.5 cm long slit-shaped mucosal tear is created parauvularly, which is adapted using absorbable Vicyl suture 3-0. Finally, the tonsil is removed at the lower tonsil pole with a macroscopic safety margin of 0.5 cm. Hemostasis using a bipolar suture. No more bleeding. The specimen is sent in marked with a suture for a frozen section, in which the cranial, caudal, medial and lateral mucosal margins are found to be free. If the resection distance is less than 0.1 cm in the basal/wound base area of the cranial third of the specimen (but the wound base is clinically clearly tumor-free), a marginal sample is taken in the wound base of the cranial third both medially, laterally and cranially. These are sent in for definitive histology. The marginal sample was taken after the frozen section result was communicated following the OGD/PEG procedure. Insertion of the flexible endoscope under air insufflation after insertion of a bite guard and inspection of the oesophageal mucosa, which appears circularly reddened in the area of the gastro-oesophageal junction, which could be a mucosal metaplasia. Then in the stomach air insufflation and unfolding of the mucosal relief, which is rosy on all sides, but shows various areas of a cobblestone relief in the region of the gastric outlet and obiquitously. If diaphanoscopy is very good, a PEG is placed in the typical manner using the thread pull-through method. After problem-free PEG placement, suction of the air and mirroring back, whereby a renewed inspection of the esophageal mucosa shows idem. Final enoral inspection, no evidence of bleeding. Conclusion: Panendoscopy, frozen section controlled R0 resection for tumor tonsillectomy on the right, PEG placement for cT2 cN3 tonsillar carcinoma on the right. Intraoperative case discussion : Planning of two-stage neck dissection on the right. Tumor board, question about pulmonary filia. In case of the above-mentioned gastric findings, gastroenterolog. Clarification recommended \ No newline at end of file diff --git a/573/InvasionFront_CD3_block7_x5_y4_patient573_0.json b/573/InvasionFront_CD3_block7_x5_y4_patient573_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3f41b7cc5db49eabc5c0491ac508e97d247aea4a --- /dev/null +++ b/573/InvasionFront_CD3_block7_x5_y4_patient573_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 9619.9, + "Num Detections": 24040, + "Num Negative": 21667, + "Num Positive": 2373, + "Positive %": 9.871, + "Num Positive per mm^2": 925.86 + } +} \ No newline at end of file diff --git a/573/InvasionFront_CD3_block7_x6_y4_patient573_1.json b/573/InvasionFront_CD3_block7_x6_y4_patient573_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3824af3a5d68e3f090a0523a9e4a18b62994d266 --- /dev/null +++ b/573/InvasionFront_CD3_block7_x6_y4_patient573_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 9644.9, + "Num Detections": 24848, + "Num Negative": 21021, + "Num Positive": 3827, + "Positive %": 15.4, + "Num Positive per mm^2": 1513.2 + } +} \ No newline at end of file diff --git a/573/InvasionFront_CD8_block7_x5_y4_patient573_0.json b/573/InvasionFront_CD8_block7_x5_y4_patient573_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7087eff2b5fac8eb0037565ff588735d3e11a1f6 --- /dev/null +++ b/573/InvasionFront_CD8_block7_x5_y4_patient573_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 10844.3, + "Num Detections": 24010, + "Num Negative": 21200, + "Num Positive": 2810, + "Positive %": 11.7, + "Num Positive per mm^2": 1115.2 + } +} \ No newline at end of file diff --git a/573/InvasionFront_CD8_block7_x6_y4_patient573_1.json b/573/InvasionFront_CD8_block7_x6_y4_patient573_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f8b93330a29d672578e4ba55fe5622fc4b313849 --- /dev/null +++ b/573/InvasionFront_CD8_block7_x6_y4_patient573_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20689.0, + "Centroid Y µm": 11119.1, + "Num Detections": 22764, + "Num Negative": 17771, + "Num Positive": 4993, + "Positive %": 21.93, + "Num Positive per mm^2": 1999.9 + } +} \ No newline at end of file diff --git a/573/TumorCenter_CD3_block7_x5_y4_patient573_0.json b/573/TumorCenter_CD3_block7_x5_y4_patient573_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e0a1fd4c5637bfd83ae92ff4ac948cb0724a4d9 --- /dev/null +++ b/573/TumorCenter_CD3_block7_x5_y4_patient573_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 10094.7, + "Num Detections": 22695, + "Num Negative": 18160, + "Num Positive": 4535, + "Positive %": 19.98, + "Num Positive per mm^2": 1796.1 + } +} \ No newline at end of file diff --git a/573/TumorCenter_CD3_block7_x6_y4_patient573_1.json b/573/TumorCenter_CD3_block7_x6_y4_patient573_1.json new file mode 100644 index 0000000000000000000000000000000000000000..31c106b86d69ffcb9e8125cf2fccbd2d14b6bc22 --- /dev/null +++ b/573/TumorCenter_CD3_block7_x6_y4_patient573_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 10144.6, + "Num Detections": 23078, + "Num Negative": 17341, + "Num Positive": 5737, + "Positive %": 24.86, + "Num Positive per mm^2": 2234.8 + } +} \ No newline at end of file diff --git a/573/TumorCenter_CD8_block7_x5_y4_patient573_0.json b/573/TumorCenter_CD8_block7_x5_y4_patient573_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1cbe53f45c6d5728e0f0546700cefa9a5bf57a02 --- /dev/null +++ b/573/TumorCenter_CD8_block7_x5_y4_patient573_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 10194.6, + "Num Detections": 24039, + "Num Negative": 20757, + "Num Positive": 3282, + "Positive %": 13.65, + "Num Positive per mm^2": 1305.9 + } +} \ No newline at end of file diff --git a/573/TumorCenter_CD8_block7_x6_y4_patient573_1.json b/573/TumorCenter_CD8_block7_x6_y4_patient573_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f15cc53f6d3a29381b2e562c532f1170fd7c7105 --- /dev/null +++ b/573/TumorCenter_CD8_block7_x6_y4_patient573_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 10244.6, + "Num Detections": 24615, + "Num Negative": 22162, + "Num Positive": 2453, + "Positive %": 9.965, + "Num Positive per mm^2": 962.12 + } +} \ No newline at end of file diff --git a/573/history_text.txt b/573/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..689189ed06ac569891269c0bd3e4a787762a6045 --- /dev/null +++ b/573/history_text.txt @@ -0,0 +1 @@ +In the patient <2014>, a cT1 cN2b tonsillar carcinoma on the left side was histologically confirmed by panendoscopy; the tumor was classified as easily resectable transorally. \ No newline at end of file diff --git a/573/icd_codes.txt b/573/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/573/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/573/ops_codes.txt b/573/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3edcdf2bd7cb45e2ef7d94fd48404c3a6ea67abe --- /dev/null +++ b/573/ops_codes.txt @@ -0,0 +1 @@ +Radikale Resektion des Pharynx [Pharyngektomie] durch Pharyngotomie mit Rekonstruktion mit gestieltem regionalen Lappen[5-296.12 ] Transorale radikale Resektion des Pharynx [Pharyngektomie] sonstige[5-296.0x ] Radikale erweiterte Neck dissection in 5 Regionen[5-403.31 L] Gestielte regionale Lappenplastik mit Fernlappen an der Brustwand[5-906.2a ] Perkutan-endoskopische Gastrostomie[5-431.2 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/573/patient_clinical_data.json b/573/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..57b30c088325d68d48fac905b0204b4661d88590 --- /dev/null +++ b/573/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 37, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/573/patient_pathological_data.json b/573/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ae362b2f72a119aea8609be12e56919386b23d34 --- /dev/null +++ b/573/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "573", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 23.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R2", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 53.0 +} \ No newline at end of file diff --git a/573/surgery_description.txt b/573/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ef364b9db154fca930d74d3efa0e0d0d50c1101a --- /dev/null +++ b/573/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion, Neck dissection links, Defektdeckung (Pectoralis-major-Lappen), Tracheotomie, PEG-Anlage diff --git a/573/surgery_report.txt b/573/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ead74f71b9de43d1632dcd1f4454dbd21bdc556 --- /dev/null +++ b/573/surgery_report.txt @@ -0,0 +1 @@ +First insertion of the PEG tube. For this, insertion with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach. Here, with good diaphanoscopy, problem-free puncture of the stomach and subsequent placement of the PEG tube using the usual thread pull-through method. Regular esophagus on reflection. Inspection and palpation are now performed. There is a coarse tumor limited to the left tonsil, but with a clearly submucosal part. Exposure with the tonsil retractor. Mucosal incision as for tumor tonsillectomy. It quickly becomes apparent that the tumor clearly infiltrates the muscles of the posterior palatal arch submucosally. After removal of the anterior palatal arch, the tumor can be seen growing in depth per continuitatem into the soft tissues of the neck and on cervical palpation with direct adhesion to the lymph node metastasis. Complete detachment from the mucosal level, this is covered with marginal samples, which are later classified as tumor-free. Now repositioning for neck dissection of the left side. Injection of xylocaine with added adrenaline, cutting of skin and subcutaneous tissue. Separation of the external jugular vein. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. It is palpable that the metastasis in the upper part infiltrates the sternocleidomastoid muscle. Visualization of the submandibular gland and the digastric muscle. This shows that the posterior venter is also infiltrated. Therefore, the sternocleidomastoid muscle is now exposed caudally. Exposure of the internal jugular vein. This shows that it is completely infiltrated and occluded from approx. level III, therefore the vein is removed caudally. Exposure of the common carotid artery and vagus nerve en bloc. Dissection of the markedly hard metastasis which firmly infiltrates the surrounding area, taking level V with it. The cervical plexus must be taken subtotally. Cranially, the metastasis can be seen growing ever closer to the spinal column. In the area of the spine, the metastasis can be resected in sano, taking the musculature with it. Extirpation of the submandibular gland and the digastric muscle. Removal of the muscular pharyngeal side wall and thus resection of the tumor with the ..............., which is located directly at the metastasis as described above. Resection with absolute infiltration of the hypoglossal nerve. After complete removal, it is now clear that the tumor surrounds the carotid bulb as well as the external and internal carotid arteries by almost 360°. After visualization, there is a clear infiltration of the carotid bulb and the internal carotid artery. Now add . Confirmation of the findings. The tumor is now debulked as far as possible. Deposition of the external carotid artery close to the bulb. The internal carotid artery can now be freed from the tumor over a long distance. In the case of bulbar infiltration, extremely vulnerable conditions, new vascular suture required here, therefore no further measures here so that an overall R2 situation remains at the carotid bulb after complete resection. Due to the overall situation, the indication for defect coverage and vascular protection using a pectoralis major flap is now given. Lifting of the pectoralis major flap (): First draw in the deltopectoral flap and the skin island. The skin island is 8 x 10 cm in size. In consultation with , cut around the skin island, then cut through a very thick layer of fat. Dissection down to the musculature. Then removal of the pectoralis major muscle from the chest wall, partly sharp, partly blunt. Blunt exposure of the pectoralis minor muscle and exposure of the vascular pedicle. This is successful without any problems. Then create a tunnel in the area of the deltopectoral flap while protecting the fascia of the pectoralis major muscle. Then cut through the pectoralis major muscle lateral and medial to the vascular pedicle. This must be done as far up as possible, as the flap must extend into the tonsil region and the defect is relatively large and there is also a large subcutaneous fat layer. Sutures are then placed in the caudal region. Pulling through the pectoralis major flap and fixation in the cranial region from the enoral side. The remaining suture fixation from transcervical. The flap was vital and supplied with blood until the end of the operation. Redon drains were then inserted and the skin was sutured in 2 or 3 layers, also in the chest area. Unfortunately, the wound in the neck area cannot be completely closed, as otherwise pressure would have to be applied to the vascular pedicle. Therefore, full-thickness skin was removed from the excess skin on the breast, meshed and covered the open defect with meshed full-thickness skin. Unfortunately, this is not completely sufficient, so that the remaining part of the secondary granulation must be left in place. \ No newline at end of file diff --git a/574/InvasionFront_CD3_block19_x5_y8_patient574_0.json b/574/InvasionFront_CD3_block19_x5_y8_patient574_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5c682aa7774c797b527f7235066d41b7873d200e --- /dev/null +++ b/574/InvasionFront_CD3_block19_x5_y8_patient574_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 22688.0, + "Num Detections": 16446, + "Num Negative": 16197, + "Num Positive": 249, + "Positive %": 1.514, + "Num Positive per mm^2": 138.71 + } +} \ No newline at end of file diff --git a/574/InvasionFront_CD3_block19_x6_y8_patient574_1.json b/574/InvasionFront_CD3_block19_x6_y8_patient574_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9a3c262ad6213fc4cfdf712c7ae9b4600d9d04c5 --- /dev/null +++ b/574/InvasionFront_CD3_block19_x6_y8_patient574_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 22812.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/574/InvasionFront_CD8_block19_x5_y8_patient574_0.json b/574/InvasionFront_CD8_block19_x5_y8_patient574_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bf819a82c0d8b0ac4c7c3a863fb17c0fca52b054 --- /dev/null +++ b/574/InvasionFront_CD8_block19_x5_y8_patient574_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 30059.1, + "Num Detections": 24069, + "Num Negative": 23724, + "Num Positive": 345, + "Positive %": 1.433, + "Num Positive per mm^2": 136.29 + } +} \ No newline at end of file diff --git a/574/InvasionFront_CD8_block19_x6_y8_patient574_1.json b/574/InvasionFront_CD8_block19_x6_y8_patient574_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5234d86dae2adf625d794de56460e11a5eee24d5 --- /dev/null +++ b/574/InvasionFront_CD8_block19_x6_y8_patient574_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 30209.0, + "Num Detections": 24648, + "Num Negative": 19350, + "Num Positive": 5298, + "Positive %": 21.49, + "Num Positive per mm^2": 2026.0 + } +} \ No newline at end of file diff --git a/574/TumorCenter_CD3_block19_x5_y8_patient574_0.json b/574/TumorCenter_CD3_block19_x5_y8_patient574_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e51b97a249c935ff206bc819ac8a2412ef445aa2 --- /dev/null +++ b/574/TumorCenter_CD3_block19_x5_y8_patient574_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17765.6, + "Centroid Y µm": 20464.2, + "Num Detections": 22269, + "Num Negative": 20820, + "Num Positive": 1449, + "Positive %": 6.507, + "Num Positive per mm^2": 579.49 + } +} \ No newline at end of file diff --git a/574/TumorCenter_CD3_block19_x6_y8_patient574_1.json b/574/TumorCenter_CD3_block19_x6_y8_patient574_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0b2f25214479eba3706b673ae0fb5013da6b8516 --- /dev/null +++ b/574/TumorCenter_CD3_block19_x6_y8_patient574_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20314.2, + "Centroid Y µm": 20189.3, + "Num Detections": 20486, + "Num Negative": 19220, + "Num Positive": 1266, + "Positive %": 6.18, + "Num Positive per mm^2": 558.85 + } +} \ No newline at end of file diff --git a/574/TumorCenter_CD8_block19_x5_y8_patient574_0.json b/574/TumorCenter_CD8_block19_x5_y8_patient574_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8bbb361fb125db08348def5974eb2af2323002de --- /dev/null +++ b/574/TumorCenter_CD8_block19_x5_y8_patient574_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 31183.5, + "Num Detections": 22648, + "Num Negative": 21161, + "Num Positive": 1487, + "Positive %": 6.566, + "Num Positive per mm^2": 580.23 + } +} \ No newline at end of file diff --git a/574/TumorCenter_CD8_block19_x6_y8_patient574_1.json b/574/TumorCenter_CD8_block19_x6_y8_patient574_1.json new file mode 100644 index 0000000000000000000000000000000000000000..15303fe297ddf4ae312fe0a7085de130e98e97dd --- /dev/null +++ b/574/TumorCenter_CD8_block19_x6_y8_patient574_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21438.6, + "Centroid Y µm": 31183.5, + "Num Detections": 19897, + "Num Negative": 18835, + "Num Positive": 1062, + "Positive %": 5.337, + "Num Positive per mm^2": 465.44 + } +} \ No newline at end of file diff --git a/574/history_text.txt b/574/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d2cd5b98e11cf464f581b6274a82345cd6333e99 --- /dev/null +++ b/574/history_text.txt @@ -0,0 +1 @@ +The patient was diagnosed with glottic laryngeal carcinoma on the right side during a panendoscopy and histologically confirmed. Due to the poor accessibility and infiltration of the anterior commissure, external surgery was indicated. \ No newline at end of file diff --git a/574/icd_codes.txt b/574/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d640ef013f9c3dbc48269d1122c85a48224483f --- /dev/null +++ b/574/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 R] \ No newline at end of file diff --git a/574/ops_codes.txt b/574/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d5265ac929cc0d6e44ff14a6002aea1aa1adf69 --- /dev/null +++ b/574/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] \ No newline at end of file diff --git a/574/patient_clinical_data.json b/574/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..759c38675b538c53e2a504f3da2200a5a52bc173 --- /dev/null +++ b/574/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/574/patient_pathological_data.json b/574/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bdbad03e2956531c0d71fff7cd7897ef37c70fc2 --- /dev/null +++ b/574/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "574", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/574/surgery_description.txt b/574/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..021145643e375fa0db9111a1ad07693a44011047 --- /dev/null +++ b/574/surgery_description.txt @@ -0,0 +1 @@ +KK-Teilresektion, Rekonstruktion Stimmlippe re. diff --git a/574/surgery_report.txt b/574/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce7601ed2f286910840e1b3126ba27c33ca18ffd --- /dev/null +++ b/574/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Injection of local anesthetic with adrenaline. Zigzag skin incision prelaryngeal and preparation in depth. Separation of the platysma. Further dissection in depth on the prelaryngeal muscles. This is separated in the midline. Expose the upper edge of the thyroid cartilage and the lower edge of the cricoid cartilage. Remove all soft tissue above the larynx. A clearly enlarged prelaryngeal lymph node can be seen. This is removed separately and sent for frozen section diagnostics. The lymph node is found to be tumor-free intraoperatively. After visualization of the laryngeal skeleton, incision of the periosteum and pushing the periosteum laterally. Transverse incision of the ligamentum conicum and subsequent passage of the thyrofissure in the midline. The larynx is opened in the anterior commissure. The left side looks completely unremarkable. Removal of a marginal sample from the left anterior commissure. On the right side, the exophytic tumor is visible, which completely occupies the vocal fold and partially infiltrates the morgue sinus. However, the tumor has certainly not reached the folds of the vocal fold. The tumor is now dissected subperichondrally starting at the anterior commissure. The perichondrium is pushed away from the thyroid cartilage. Dissection is carried out from ventral to dorsal with a safety distance of about 3 mm from the subglottic slope to the tumor. Also maintain a safe distance in the direction of the morgnoid sinus. The tumor reaches close to the vocal process, but certainly does not infiltrate the posterior commissure. Dissection is now performed on the anterior surface of the arytenoid cartilage. Exposure of the vocal process. The tumor can then be deposited dorsally with a tiny portion of the vocal process at a safety distance of about 2 mm. Inspection of the specimen. This is then thread-marinated. A fringe of healthy tissue can be seen all around the tumor. The specimen is sent to the frozen section marked with a thread. All the margins are marked as tumor-free. The safety margin towards the perichondrium is sometimes less than 1 mm. For this reason, a piece of perichondrium in the dorsal section of the resection area is removed again and sent separately for final histological assessment and confirmation of the R0 situation. Perform subtle hemostasis. Mobilization of the pocket fold on the right side. For this purpose, an incision is made above the pocket fold at approximately the level of the upper edge of the thyroid cartilage. Complete mobilization of the entire pocket fold caudally, which is now sutured to the subglottic slope. The anterior commissure on the left side and the newly formed caudally displaced pocket fold are also sutured ventrally. Closure of the thyrofissure and closure of the ligamentum conicum with single button sutures. Closure of the prelaryngeal musculature. Two-layer wound closure after insertion of a wound flap. Application of a pressure dressing. Final consultation with the anesthetist. Completion of the procedure. \ No newline at end of file diff --git a/575/InvasionFront_CD3_block21_x3_y8_patient575_0.json b/575/InvasionFront_CD3_block21_x3_y8_patient575_0.json new file mode 100644 index 0000000000000000000000000000000000000000..55739b109804f9e958ce82582285ca60df1c27cd --- /dev/null +++ b/575/InvasionFront_CD3_block21_x3_y8_patient575_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13168.0, + "Centroid Y µm": 30633.8, + "Num Detections": 22530, + "Num Negative": 22039, + "Num Positive": 491, + "Positive %": 2.179, + "Num Positive per mm^2": 183.71 + } +} \ No newline at end of file diff --git a/575/InvasionFront_CD3_block21_x4_y8_patient575_1.json b/575/InvasionFront_CD3_block21_x4_y8_patient575_1.json new file mode 100644 index 0000000000000000000000000000000000000000..409551e3f5e9722e0d20c7bb249e8cc2ca60ef5b --- /dev/null +++ b/575/InvasionFront_CD3_block21_x4_y8_patient575_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 30758.7, + "Num Detections": 10338, + "Num Negative": 10112, + "Num Positive": 226, + "Positive %": 2.186, + "Num Positive per mm^2": 184.73 + } +} \ No newline at end of file diff --git a/575/InvasionFront_CD8_block21_x3_y8_patient575_0.json b/575/InvasionFront_CD8_block21_x3_y8_patient575_0.json new file mode 100644 index 0000000000000000000000000000000000000000..509a5007d55a3b30b76d66188aa80c129a280ba7 --- /dev/null +++ b/575/InvasionFront_CD8_block21_x3_y8_patient575_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10769.3, + "Centroid Y µm": 19739.5, + "Num Detections": 23019, + "Num Negative": 22943, + "Num Positive": 76, + "Positive %": 0.3302, + "Num Positive per mm^2": 28.05 + } +} \ No newline at end of file diff --git a/575/InvasionFront_CD8_block21_x4_y8_patient575_1.json b/575/InvasionFront_CD8_block21_x4_y8_patient575_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7b8a74633b1316a490714711196013b0163fb022 --- /dev/null +++ b/575/InvasionFront_CD8_block21_x4_y8_patient575_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 19739.5, + "Num Detections": 20986, + "Num Negative": 20685, + "Num Positive": 301, + "Positive %": 1.434, + "Num Positive per mm^2": 126.84 + } +} \ No newline at end of file diff --git a/575/TumorCenter_CD3_block21_x3_y8_patient575_0.json b/575/TumorCenter_CD3_block21_x3_y8_patient575_0.json new file mode 100644 index 0000000000000000000000000000000000000000..54ae9a1b49837dc4a6ccc26cff2cab93b7dfa12e --- /dev/null +++ b/575/TumorCenter_CD3_block21_x3_y8_patient575_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 22588.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/575/TumorCenter_CD3_block21_x4_y8_patient575_1.json b/575/TumorCenter_CD3_block21_x4_y8_patient575_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cfa8d6dfa4e424570d0ceba5f87ff0d04883413f --- /dev/null +++ b/575/TumorCenter_CD3_block21_x4_y8_patient575_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 22575.5, + "Num Detections": 19967, + "Num Negative": 19750, + "Num Positive": 217, + "Positive %": 1.087, + "Num Positive per mm^2": 91.7 + } +} \ No newline at end of file diff --git a/575/TumorCenter_CD8_block21_x3_y8_patient575_0.json b/575/TumorCenter_CD8_block21_x3_y8_patient575_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3e1b62f45239b81811dfe27b106a4eadc3da742a --- /dev/null +++ b/575/TumorCenter_CD8_block21_x3_y8_patient575_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 34806.6, + "Num Detections": 16915, + "Num Negative": 16753, + "Num Positive": 162, + "Positive %": 0.9577, + "Num Positive per mm^2": 82.44 + } +} \ No newline at end of file diff --git a/575/TumorCenter_CD8_block21_x4_y8_patient575_1.json b/575/TumorCenter_CD8_block21_x4_y8_patient575_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dda6f357d8eb708e222956601636386da3bded7f --- /dev/null +++ b/575/TumorCenter_CD8_block21_x4_y8_patient575_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15691.7, + "Centroid Y µm": 34906.5, + "Num Detections": 20187, + "Num Negative": 20151, + "Num Positive": 36, + "Positive %": 0.1783, + "Num Positive per mm^2": 15.04 + } +} \ No newline at end of file diff --git a/575/history_text.txt b/575/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a1691d6724cb27f0c1c0c166ea2ff420cd23b4a6 --- /dev/null +++ b/575/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the right vocal fold and the ligament. \ No newline at end of file diff --git a/575/icd_codes.txt b/575/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3fc441e4d4825c4aa1cb2d74ab85b413db0db51b --- /dev/null +++ b/575/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 ] \ No newline at end of file diff --git a/575/ops_codes.txt b/575/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d75b466be422e99da15b234c3bb390ebf9b1d21 --- /dev/null +++ b/575/ops_codes.txt @@ -0,0 +1 @@ +Mikrolaryngoskopische Exzision am Larynx[5-300.2 ] Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] \ No newline at end of file diff --git a/575/patient_clinical_data.json b/575/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9c2763ed45d76791c9b7edc8f22175d697fbec76 --- /dev/null +++ b/575/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/575/patient_pathological_data.json b/575/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a224b0eda09fc92b274e2fed28d42df407356eb3 --- /dev/null +++ b/575/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "575", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 54, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/575/surgery_description.txt b/575/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f71ffb574d9cb199582c43a70d74f2b3e887fe5c --- /dev/null +++ b/575/surgery_description.txt @@ -0,0 +1 @@ +Laserresektion diff --git a/575/surgery_report.txt b/575/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ae086033d153d23e2950ebcc16ed37904e59053b --- /dev/null +++ b/575/surgery_report.txt @@ -0,0 +1 @@ +Before the start of the operation, repeat the procedure with the Kleinsasser tube. The tumor extends from the anterior commissure, reaching it and passing discreetly to the left onto the anterior vocal cord and posteriorly to the arytenoid. The pocket fold is reached superiorly. Overall, however, the tumor is very mobile and does not appear to infiltrate the cartilage clinically. Due to the extent of the tumor, the decision was made to perform a laser resection. The Kleinsasser tube is now used to adjust the anterior commissure. The tumor is now cut around the healthy part with the laser, including the anterior part of the left vocal fold and pocket fold. Excision is made in the anterior commissure down to the cartilage. The incision is then made caudally subglottically in the healthy area posteriorly. Separation of the cartilage from the arytenoid hump. The cartilage is preserved in any case, and the muscular structures are also preserved for the most part. Cranial and posterior resection of the pocket fold with the tumor. Here the tumor definitely does not reach the cartilage. Finally, the tumor can be cut around with the laser in toto microscopically and macroscopically in healthy tissue. Representative circular edge samples are taken. These are found to be tumor-free in the frozen section. Therefore, after extensive hemostasis with monopolar coagulation and supratupfer, the procedure is terminated. Wait for the definitive histology, then plan a follow-up endoscopy in 8 weeks. \ No newline at end of file diff --git a/576/InvasionFront_CD3_block4_x5_y8_patient576_0.json b/576/InvasionFront_CD3_block4_x5_y8_patient576_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b1de74d4c8381ee2307054b4454fa3dc17781403 --- /dev/null +++ b/576/InvasionFront_CD3_block4_x5_y8_patient576_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 26261.1, + "Num Detections": 19747, + "Num Negative": 19456, + "Num Positive": 291, + "Positive %": 1.474, + "Num Positive per mm^2": 120.68 + } +} \ No newline at end of file diff --git a/576/TumorCenter_CD3_block4_x5_y8_patient576_0.json b/576/TumorCenter_CD3_block4_x5_y8_patient576_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b3b7c0a1d0f9de1b1aa27858e6a6301caf15a9c --- /dev/null +++ b/576/TumorCenter_CD3_block4_x5_y8_patient576_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 20539.1, + "Num Detections": 24621, + "Num Negative": 24251, + "Num Positive": 370, + "Positive %": 1.503, + "Num Positive per mm^2": 136.32 + } +} \ No newline at end of file diff --git a/576/TumorCenter_CD3_block4_x6_y8_patient576_1.json b/576/TumorCenter_CD3_block4_x6_y8_patient576_1.json new file mode 100644 index 0000000000000000000000000000000000000000..90611f52e089efceedbc73819bed4cef35dc2369 --- /dev/null +++ b/576/TumorCenter_CD3_block4_x6_y8_patient576_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 20564.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file